{"meta":{"query_hash":"79396cb19803","filters":{"topic":"Enzyme function and inhibition"},"cohort_total":238,"direct_labels_cover":0,"predictions_cover":238,"exported":238,"export_cap":100000,"truncated":false,"label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"permalink":"https://metacan.xera.ac/q/79396cb19803","api":"https://metacan.xera.ac/api/v1/cohort?topic=Enzyme+function+and+inhibition"},"results":[{"id":"W114309945","doi":"10.1016/b978-0-444-63258-6.00019-6","title":"δ-Carbonic Anhydrases: Structure, Distribution, and Potential Roles","year":2015,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Carbonic anhydrase; Photosynthesis; Carbon dioxide; Biology; Protein primary structure; Chemistry; Biochemistry; Ecology; Enzyme; Gene; Peptide sequence","score_opus":0.007813115114600228,"score_gpt":0.21652011483122682,"score_spread":0.2087069997166266,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W114309945","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.009970341,0.84540373,0.013985285,0.0025058456,0.001228569,0.000025339308,0.0005323076,0.00026462218,0.12608401],"genre_scores_gemma":[0.041558027,0.5455288,0.011602966,0.0008415559,0.0009085653,0.000048580703,0.0009231768,0.000097090866,0.3984912],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999573,0.0000023558175,0.0000026281293,0.000013044032,0.000019836752,0.000004923271],"domain_scores_gemma":[0.9999685,0.000009580941,0.000004124773,0.0000027972203,0.000008402844,0.000006565496],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115429924,0.0005473212,0.00032028148,0.0004852444,0.00014843809,0.00081155536,0.00059393,0.00048128053,0.007970794],"category_scores_gemma":[0.00010840571,0.00022360198,0.00018812559,0.0007928749,0.0003012501,0.000846531,0.0003159335,0.0009989433,0.004875052],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015202056,0.000041208856,0.00038540678,0.0009209015,0.00001844968,0.00033432135,0.00012125801,0.0007743827,0.115363844,0.031946335,0.04894583,0.800996],"study_design_scores_gemma":[0.0000120606355,0.000058053705,0.0018508466,0.00021464053,0.000019351724,0.001488164,0.000064997475,0.0005554526,0.022795523,0.016091742,0.95683,0.000019068717],"about_ca_topic_score_codex":0.0014188098,"about_ca_topic_score_gemma":0.0027972388,"teacher_disagreement_score":0.007970794,"about_ca_system_score_codex":0.0005949935,"about_ca_system_score_gemma":0.00036502737,"threshold_uncertainty_score":0.026664913},"labels":[],"label_agreement":null},{"id":"W119760174","doi":"10.1007/978-94-007-7359-2_13","title":"Carbonic Anhydrase IX (CAIX) as a Mediator of Hypoxia-Induced Stress Response in Cancer Cells","year":2013,"lang":"en","type":"review","venue":"Sub-cellular biochemistry/Subcellular biochemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Mediator; Cancer cell; Cancer research; Cancer; Biology; Cancer stem cell; Downregulation and upregulation; Metastasis; Cell biology; Stem cell; Biochemistry; Gene","score_opus":0.01783141655742459,"score_gpt":0.2774227740685375,"score_spread":0.2595913575111129,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W119760174","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0002464823,0.9982521,0.00028845237,0.00017171369,0.00016790847,0.0000034892655,0.000018398583,0.0000080619275,0.0008434056],"genre_scores_gemma":[0.0015417305,0.9968759,0.00028328906,0.000110192654,0.00014263742,0.0000056811173,0.00004083451,0.0000018044683,0.0009979928],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99990845,0.000009036412,0.000012661867,0.000018513843,0.00003993563,0.000011438269],"domain_scores_gemma":[0.99990726,0.000025679148,0.000017919278,0.0000036618528,0.000033211578,0.000012256474],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030723092,0.0007409863,0.0009144102,0.00097400945,0.0001735003,0.0006068821,0.0006978349,0.0007156125,0.0014429374],"category_scores_gemma":[0.0002608133,0.00021793431,0.00025849688,0.0014140508,0.0003378454,0.00064943975,0.00047302913,0.0012262423,0.0012555573],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001533204,0.00006996902,0.0002145338,0.011682058,0.000093192386,0.00029953074,0.000041540243,0.0004762964,0.016766394,0.004001271,0.026354007,0.93984795],"study_design_scores_gemma":[0.000030155916,0.00009948962,0.00097447267,0.0009333088,0.00014185614,0.0010671769,0.000032625696,0.00019160472,0.0062010847,0.001341021,0.98896796,0.000019170204],"about_ca_topic_score_codex":0.0010052023,"about_ca_topic_score_gemma":0.0021178962,"teacher_disagreement_score":0.0014429374,"about_ca_system_score_codex":0.0006338611,"about_ca_system_score_gemma":0.0007591426,"threshold_uncertainty_score":0.0048271418},"labels":[],"label_agreement":null},{"id":"W1512080163","doi":"10.1113/jphysiol.2006.123638","title":"Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy","year":2006,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University; Canadian Institutes of Health Research; University of Alberta","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Muscle hypertrophy; Chemistry; Myocyte; Gene isoform; Cytosol; Biology; Enzyme; Medicine; Biochemistry","score_opus":0.004467756784034031,"score_gpt":0.20030857384097636,"score_spread":0.19584081705694234,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1512080163","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9943868,0.0024143949,0.0009444244,0.000104687155,0.00009357429,0.000037210706,0.0002348259,0.000188165,0.0015960031],"genre_scores_gemma":[0.99292713,0.0023240088,0.0009593634,0.000082992374,0.000042124,0.000041416148,0.00056780106,0.000038882354,0.003016213],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998723,0.000017271208,0.000015493257,0.000020153515,0.000036318244,0.00003839382],"domain_scores_gemma":[0.99986243,0.000025944484,0.00003389819,0.000013806739,0.000012849638,0.00005113234],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014692149,0.0004379606,0.00044778406,0.00018541234,0.000121206256,0.00021850753,0.0002979954,0.00029898228,0.0012133728],"category_scores_gemma":[0.00015344018,0.00015343288,0.00022678137,0.00009173048,0.00021957933,0.00017331263,0.00019115042,0.0007349877,0.00026656606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004622363,0.00011535405,0.00013532094,0.00004690596,0.000012343509,0.00007099522,0.000013120929,0.00006283,0.9964012,0.000070442395,0.00008010797,0.0025291385],"study_design_scores_gemma":[0.00013481251,0.0026345216,0.008300656,0.0000133207,0.000039523642,0.00031355218,0.000036039233,0.0006146612,0.98539007,0.000051666568,0.0024634688,0.000007610557],"about_ca_topic_score_codex":0.00065225526,"about_ca_topic_score_gemma":0.0015018263,"teacher_disagreement_score":0.0012133728,"about_ca_system_score_codex":0.00018616326,"about_ca_system_score_gemma":0.0002864687,"threshold_uncertainty_score":0.004059136},"labels":[],"label_agreement":null},{"id":"W1542699111","doi":"","title":"Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Hypoxia (environmental); Tumor hypoxia; Pathology; Immunohistochemistry; Biopsy; Medicine; Staining; Radiation therapy; Cervix; Internal medicine; Cancer; Chemistry","score_opus":0.006323134180266133,"score_gpt":0.18030251210013928,"score_spread":0.17397937791987314,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1542699111","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9991092,0.00060674024,0.000040967312,0.000026532165,0.0000016958711,0.0000035859368,0.000072077826,0.0000022671761,0.00013696909],"genre_scores_gemma":[0.9996462,0.0001311456,0.00004119959,0.000008488478,0.0000037997627,0.0000042843017,0.000111244735,5.1880585e-7,0.000053170348],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9998807,0.000023460629,0.000013338568,0.000033602944,0.000025498179,0.000023338986],"domain_scores_gemma":[0.999488,0.00014419552,0.00020416928,0.00002765796,0.00004564765,0.000090257105],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024726777,0.00017353239,0.00030342117,0.0003694848,0.00024224093,0.00024062267,0.00015866177,0.00036913189,0.00056475546],"category_scores_gemma":[0.0011099646,0.00010513371,0.00014316838,0.00052254973,0.00029785195,0.00021445462,0.00021417222,0.00025080174,0.000121583624],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030128527,0.000014104489,0.9963983,0.00001400732,0.000020383794,0.00012682898,0.000033895954,0.000057695426,0.0011050727,0.0000060123393,0.00004282264,0.0018794504],"study_design_scores_gemma":[0.0000068668496,0.00016836992,0.9985185,0.0000044337276,0.000026480366,0.0006081282,0.000059203256,0.00019312547,0.00027197527,0.000018010742,0.00012241899,0.0000025542133],"about_ca_topic_score_codex":0.0018928519,"about_ca_topic_score_gemma":0.0024825542,"teacher_disagreement_score":0.0018928519,"about_ca_system_score_codex":0.00040727426,"about_ca_system_score_gemma":0.0002292952,"threshold_uncertainty_score":0.0037636757},"labels":[],"label_agreement":null},{"id":"W1567126644","doi":"10.3968/j.ans.1715787020120501.1120","title":"Endosymbiotic Actinidic Archaeal Digoxin Inhibited Sodium Potassium ATPase Mediated ATP Synthesis and Archaeal Ectoatpases Produce Neuro-Immuno- Metabolic-Endocrine/Cell Cycle Regulation","year":2012,"lang":"en","type":"article","venue":"Advances in natural science/Advances in natural sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Biology; Digoxin; Internal medicine; Endomyocardial fibrosis; ATPase; Biochemistry; Endocrinology; Pharmacology; Enzyme; Medicine; Fibrosis; Heart failure","score_opus":0.006024519549346544,"score_gpt":0.2615312156090175,"score_spread":0.25550669605967097,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1567126644","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99094266,0.0030992937,0.0021571864,0.00008114816,0.000059253645,0.000045297922,0.0005075401,0.000045806188,0.0030616308],"genre_scores_gemma":[0.99072266,0.0010881316,0.0020401923,0.000057857807,0.000009546598,0.00003828612,0.00095091487,0.0000081730705,0.0050841807],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999299,0.00000932144,0.0000069495445,0.000020186548,0.000015840993,0.000017871589],"domain_scores_gemma":[0.99995494,0.0000073215933,0.000010861939,0.000007985997,0.000009478415,0.000009321522],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007359008,0.00021998065,0.00014465464,0.000089811045,0.0001088063,0.0001786988,0.00011651389,0.00015952844,0.0014207683],"category_scores_gemma":[0.00006963072,0.00007284211,0.0001250615,0.000095080395,0.00017423987,0.000093855655,0.00012451924,0.0002429179,0.00029959434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024552445,0.000019235842,0.00044645747,0.000055104647,0.0000030623605,0.0000734827,0.000013234401,0.000013670219,0.99765944,0.000064964755,0.00004012027,0.0013656785],"study_design_scores_gemma":[0.00002585177,0.0005895574,0.013290319,0.000015416377,0.000017282753,0.00054479204,0.000055680874,0.00023954223,0.9797009,0.0000571824,0.005459261,0.0000043197197],"about_ca_topic_score_codex":0.0007815071,"about_ca_topic_score_gemma":0.0009977259,"teacher_disagreement_score":0.0014207683,"about_ca_system_score_codex":0.00014386656,"about_ca_system_score_gemma":0.00018220444,"threshold_uncertainty_score":0.004752934},"labels":[],"label_agreement":null},{"id":"W1590224923","doi":"10.1071/pp01179","title":"Characterization of the C-terminal extension of carboxysomal carbonic anhydrase from <i>Synechocystis</i> sp. PCC6803","year":2002,"lang":"en","type":"article","venue":"Australian Journal of Plant Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Amorfix (Canada); Dairy Farmers of Ontario","funders":"","keywords":"Carbonic anhydrase; Biology; Biochemistry; Synechocystis; Enzyme; Recombinant DNA; Gene; Genetics","score_opus":0.014292250905787991,"score_gpt":0.2069436966000509,"score_spread":0.19265144569426293,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1590224923","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9929646,0.000794642,0.0034596988,0.0000959919,0.000016352576,0.00003722253,0.0015346706,0.0000344262,0.0010623329],"genre_scores_gemma":[0.9788472,0.0008812111,0.0057428186,0.00012828546,0.000019048104,0.00004928838,0.012047242,0.000064027074,0.0022209182],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985075,0.000011807207,0.00001595478,0.0000347404,0.0000608709,0.000025762763],"domain_scores_gemma":[0.99956363,0.00007572775,0.00009242916,0.000044081422,0.000116911855,0.000107191394],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015599292,0.00040438335,0.00026817506,0.00023067866,0.0001554185,0.00036215805,0.00023240744,0.00021592306,0.0002972097],"category_scores_gemma":[0.00040485105,0.00014089639,0.00038422982,0.00038588827,0.00021338239,0.00017535406,0.00017359098,0.0003854373,0.00042178092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000035032066,0.0000072387966,0.0004076097,0.000026489126,0.000003222721,0.000067194735,0.000025713985,0.000036327292,0.998706,0.00002697564,0.000014719718,0.000643595],"study_design_scores_gemma":[0.00001994168,0.00014231514,0.0628052,0.000020324369,0.000036621568,0.0011424427,0.00013148788,0.0006930482,0.92866534,0.00009223288,0.006228416,0.000022690021],"about_ca_topic_score_codex":0.008123672,"about_ca_topic_score_gemma":0.0058795945,"teacher_disagreement_score":0.008123672,"about_ca_system_score_codex":0.00046348086,"about_ca_system_score_gemma":0.00055927795,"threshold_uncertainty_score":0.01615274},"labels":[],"label_agreement":null},{"id":"W1766927364","doi":"10.1158/1538-7445.am2014-841","title":"Abstract 841: Therapeutic targeting of cancer cells in the hypoxic microenvironment using an orally bioavailable small molecule inhibitor of carbonic anhydrase IX","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SignalChem (Canada)","funders":"","keywords":"In vivo; Pharmacology; Carbonic anhydrase; Bioavailability; Chemistry; Carbonic anhydrase inhibitor; ADME; Cancer; Cancer cell; Carbonic anhydrase II; Oral administration; Extracellular; Cancer research; Pharmacokinetics; Enzyme; Biochemistry; Biology; Medicine; Internal medicine","score_opus":0.05317285775975756,"score_gpt":0.3333135282114789,"score_spread":0.28014067045172136,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1766927364","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9906529,0.0022787482,0.0024521218,0.00019867271,0.000048744176,0.00014471775,0.0004168074,0.00009941384,0.003707892],"genre_scores_gemma":[0.98859733,0.0019931216,0.002526739,0.00010511325,0.000025142346,0.00011043038,0.00088070653,0.000014853039,0.005746771],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999596,0.000008099767,0.000002981307,0.000008136682,0.000009844747,0.000011344556],"domain_scores_gemma":[0.9999752,0.0000052187834,0.000007599457,0.000002057657,0.000004185799,0.000005702238],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008498843,0.0003577387,0.0002961945,0.00012764143,0.00008187293,0.00014878258,0.00015534471,0.00026920257,0.0011933538],"category_scores_gemma":[0.00006179481,0.0000863364,0.0001541764,0.00010137228,0.000101042795,0.00009655168,0.00007831741,0.00036264193,0.00037379385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040139726,0.00025999703,0.00013856923,0.0000933244,0.000011176368,0.00007846952,0.000013966609,0.0002946259,0.991372,0.00011405147,0.00034870688,0.0068737343],"study_design_scores_gemma":[0.0003289477,0.00545324,0.004528239,0.000011671232,0.00004603809,0.00047381688,0.000015075189,0.0021399232,0.98106396,0.000028256009,0.005902367,0.000008352277],"about_ca_topic_score_codex":0.0005616487,"about_ca_topic_score_gemma":0.00071021984,"teacher_disagreement_score":0.0011933538,"about_ca_system_score_codex":0.0002098819,"about_ca_system_score_gemma":0.0002107506,"threshold_uncertainty_score":0.0039921403},"labels":[],"label_agreement":null},{"id":"W1826445496","doi":"10.1007/s00360-015-0942-4","title":"Phosphorylation increases the catalytic activity of rainbow trout gill cytosolic carbonic anhydrase","year":2015,"lang":"en","type":"article","venue":"Journal of Comparative Physiology B","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphorylation; Kinase; Carbonic anhydrase; Phosphatase; Biochemistry; Rainbow trout; Protein phosphorylation; Stimulation; Protein kinase A; Trout; Biology; Chemistry; Cell biology; Enzyme; Endocrinology","score_opus":0.03596282583923421,"score_gpt":0.29356934793876477,"score_spread":0.25760652209953055,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1826445496","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9977343,0.0003382098,0.00052019366,0.00016775531,0.000047372054,0.000006335041,0.00010230861,0.00004627724,0.0010373066],"genre_scores_gemma":[0.9977507,0.00014598764,0.000226655,0.000041776046,0.000011887135,0.0000053114873,0.0001500473,0.000015875783,0.001651762],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989235,0.000011779267,0.000008730714,0.000026175998,0.000018762172,0.000042268504],"domain_scores_gemma":[0.99989784,0.000012494435,0.000024718067,0.000015128047,0.000008452126,0.000041400104],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012724478,0.00039075542,0.00023587546,0.00011586773,0.00017565009,0.00037295505,0.00023960164,0.0003070599,0.0029153647],"category_scores_gemma":[0.00020333602,0.00026598645,0.00028517543,0.00008672016,0.00040074647,0.00028107574,0.00029298346,0.0005691862,0.0004005639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00064208044,0.000028464092,0.0003414455,0.000020737692,0.0000061821597,0.000028390838,0.000011106747,0.000053589025,0.9979444,0.000157302,0.00006751855,0.00069883734],"study_design_scores_gemma":[0.00007732706,0.0004478084,0.013283285,0.000004144994,0.000021876072,0.00013900525,0.000026195592,0.0010180745,0.98386836,0.000128074,0.0009776133,0.000008242125],"about_ca_topic_score_codex":0.0025678226,"about_ca_topic_score_gemma":0.0032112019,"teacher_disagreement_score":0.0029153647,"about_ca_system_score_codex":0.0005908951,"about_ca_system_score_gemma":0.000553422,"threshold_uncertainty_score":0.00975281},"labels":[],"label_agreement":null},{"id":"W1965932017","doi":"10.1016/j.bmc.2012.09.027","title":"Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure–activity relationships for the interaction of human carbonic anhydrase isoforms I and II","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Carbonic anhydrase; Isozyme; Stereochemistry; Carbonic Anhydrase I; Gene isoform; Carbonic anhydrase II; Enzyme; Docking (animal); Indole test; In silico; Benzene; Structure–activity relationship; Benzene derivatives; Chemical synthesis; In vitro; Biochemistry; Organic chemistry; Gene","score_opus":0.02109319410710967,"score_gpt":0.25771127124217685,"score_spread":0.2366180771350672,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1965932017","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9315561,0.012194803,0.035073638,0.00073695404,0.00027120282,0.0005403111,0.0021457982,0.0004989192,0.016982183],"genre_scores_gemma":[0.9770588,0.0047168233,0.010439616,0.00014469243,0.000035277375,0.0001641423,0.00091806916,0.000030882453,0.0064917402],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998715,0.000027236287,0.0000122992415,0.000015129264,0.000022095692,0.000051850384],"domain_scores_gemma":[0.99991274,0.000011944758,0.000023994582,0.00000765261,0.000014398979,0.000029290082],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032065084,0.00036086704,0.00030079982,0.00025284712,0.0002120521,0.00015326003,0.0004959097,0.00030081588,0.0029156252],"category_scores_gemma":[0.00022465228,0.00018245132,0.00023650195,0.00031510356,0.00014586409,0.00022255149,0.00020819432,0.00042085454,0.0008449584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036568684,0.00022197506,0.00017809731,0.00027510483,0.00002341553,0.0002846495,0.00011720814,0.0013071579,0.9830772,0.0016711799,0.0007942716,0.011684131],"study_design_scores_gemma":[0.00017047867,0.002516097,0.002136281,0.000025216978,0.00004086594,0.00029524666,0.000029371286,0.0018716411,0.9771095,0.00014231045,0.015629193,0.000033777334],"about_ca_topic_score_codex":0.00094168563,"about_ca_topic_score_gemma":0.002748831,"teacher_disagreement_score":0.0029156252,"about_ca_system_score_codex":0.0003555801,"about_ca_system_score_gemma":0.00042092736,"threshold_uncertainty_score":0.009753704},"labels":[],"label_agreement":null},{"id":"W1966677271","doi":"10.1007/s10529-015-1803-7","title":"Surface display of highly-stable Desulfovibrio vulgaris carbonic anhydrase on polyester beads for CO2 capture","year":2015,"lang":"en","type":"article","venue":"Biotechnology Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Massey University; Public Health Agency of Canada","keywords":"Desulfovibrio vulgaris; Polyester; Carbonic anhydrase; Chemistry; Carbonic acid; Bacteria; Desulfovibrio; Microbiology; Biochemistry; Chromatography; Enzyme; Biology; Organic chemistry","score_opus":0.013241827503390202,"score_gpt":0.23028987788075106,"score_spread":0.21704805037736086,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966677271","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9912042,0.00037074884,0.006103894,0.00008313805,0.000027017706,0.000017745228,0.000147747,0.00012621272,0.0019191613],"genre_scores_gemma":[0.994679,0.0001775149,0.0020079513,0.000043641932,0.000006746666,0.000015326072,0.00021129285,0.00002455615,0.0028340344],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998265,0.00001536398,0.000006369465,0.000033245844,0.00005554765,0.00006305615],"domain_scores_gemma":[0.9999361,0.000010307936,0.000010947895,0.000007184928,0.000013236763,0.0000221919],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117144096,0.00039796453,0.00022435284,0.00015606626,0.0001565823,0.0004034637,0.00031502338,0.00040844028,0.000882075],"category_scores_gemma":[0.00013090578,0.00016039556,0.00026675191,0.00015784526,0.00011914849,0.00020222177,0.0003137274,0.0003904525,0.00040193714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000025216685,0.000008587378,0.00003735951,0.00000831064,0.0000025629658,0.000019394709,0.0000057182287,0.000057565714,0.9993426,0.000022806287,0.00002049439,0.0004492448],"study_design_scores_gemma":[0.0000027488,0.000028368122,0.0005035919,8.6357346e-7,0.0000029725863,0.000020368725,0.000006729216,0.0008431908,0.9981725,0.000006280794,0.00040924476,0.0000030811327],"about_ca_topic_score_codex":0.00086647173,"about_ca_topic_score_gemma":0.0018007425,"teacher_disagreement_score":0.000882075,"about_ca_system_score_codex":0.00033814716,"about_ca_system_score_gemma":0.00012139906,"threshold_uncertainty_score":0.0029509068},"labels":[],"label_agreement":null},{"id":"W1967412933","doi":"10.1016/j.ejmech.2011.12.022","title":"Structure–activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Carbonic Anhydrase I; Carbonic anhydrase; Stereochemistry; Indole test; Isozyme; Gene isoform; Enzyme; Carbonic anhydrase II; Docking (animal); Structure–activity relationship; Active site; Biochemistry; In vitro","score_opus":0.02415928855435353,"score_gpt":0.2364411026035657,"score_spread":0.21228181404921218,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1967412933","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9928558,0.0043464424,0.0007522336,0.00006807261,0.000019191113,0.00001700128,0.0004335112,0.000027204918,0.0014805107],"genre_scores_gemma":[0.9960919,0.0010872913,0.0004829353,0.000022332959,0.000007584962,0.000007862196,0.00097093766,0.0000034913041,0.001325663],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999212,0.000021617427,0.000005670283,0.00001105503,0.000018214725,0.000022140286],"domain_scores_gemma":[0.99987817,0.000056554614,0.000025589368,0.0000056416193,0.000014255469,0.000019682457],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017443237,0.00016714548,0.00013912705,0.00012332352,0.00008118597,0.00013389884,0.00025330702,0.00018044372,0.0015985759],"category_scores_gemma":[0.00019809617,0.00008888661,0.0002404477,0.00013715347,0.00011054612,0.00008802665,0.000037286314,0.0002306815,0.00026186855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011530088,0.00018355304,0.0013556998,0.000066031345,0.000031892443,0.00009064282,0.000026816619,0.0012364128,0.9916433,0.00014778624,0.00021804345,0.0038467254],"study_design_scores_gemma":[0.00010533543,0.0033253483,0.017073074,0.000008535755,0.00007739618,0.0003841603,0.00003223441,0.0070309266,0.9692682,0.000042054184,0.0026390413,0.00001371446],"about_ca_topic_score_codex":0.0027850326,"about_ca_topic_score_gemma":0.004006505,"teacher_disagreement_score":0.0027850326,"about_ca_system_score_codex":0.000271324,"about_ca_system_score_gemma":0.00012943543,"threshold_uncertainty_score":0.005537629},"labels":[],"label_agreement":null},{"id":"W1967429167","doi":"10.1021/ie101338r","title":"Kinetic Model for the Reversible Hydration of Carbon Dioxide Catalyzed by Human Carbonic Anhydrase II","year":2010,"lang":"en","type":"article","venue":"Industrial & Engineering Chemistry Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Intermolecular force; Carbonic anhydrase; Proton; Bicarbonate; Catalysis; Carbon dioxide; Enzyme; Molecule; Organic chemistry","score_opus":0.04240478136623803,"score_gpt":0.3013212963516779,"score_spread":0.2589165149854399,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1967429167","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.41298378,0.0016106587,0.5624136,0.0011436938,0.00019264141,0.000434062,0.0009978614,0.0007420301,0.01948165],"genre_scores_gemma":[0.9690112,0.0009292964,0.013489519,0.000084966196,0.000024593232,0.0005793645,0.0003243025,0.000054646305,0.015501972],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99985516,0.000026241507,0.000011773437,0.00004509743,0.000029650062,0.00003203033],"domain_scores_gemma":[0.99977773,0.000101098965,0.000040044622,0.000017566708,0.000042091862,0.00002147199],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044507353,0.0009816899,0.00081842905,0.00046887997,0.00035580594,0.0007597021,0.0018978745,0.0011175829,0.002195511],"category_scores_gemma":[0.00080380554,0.0004668536,0.00081154576,0.00023445794,0.00058448495,0.0010909219,0.00038302768,0.00079884223,0.00071669905],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017777992,0.00012739148,0.0012239056,0.00023754033,0.000059926064,0.00048656703,0.00016771904,0.88290507,0.05605781,0.052187856,0.000576069,0.0057923608],"study_design_scores_gemma":[0.000022455726,0.00004273488,0.0002179933,0.000003045923,0.000012543295,0.000056134846,0.000009210381,0.99368894,0.002356854,0.0031415445,0.00043200422,0.000016511234],"about_ca_topic_score_codex":0.005072733,"about_ca_topic_score_gemma":0.0015307975,"teacher_disagreement_score":0.005072733,"about_ca_system_score_codex":0.0012335659,"about_ca_system_score_gemma":0.0010309912,"threshold_uncertainty_score":0.010086417},"labels":[],"label_agreement":null},{"id":"W1968725397","doi":"10.1006/bcmd.2000.0353","title":"A Membrane Metabolon Linking Carbonic Anhydrase with Chloride/Bicarbonate Anion Exchangers","year":2001,"lang":"en","type":"review","venue":"Blood Cells Molecules and Diseases","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Carbonic anhydrase; Bicarbonate; Chemistry; Band 3; Carbonic anhydrase II; Anion exchanger; Enzyme; Biochemistry; Membrane; Cytosol; Transporter; Ion exchange; Membrane protein; Inorganic chemistry; Ion; Organic chemistry","score_opus":0.011460050085693545,"score_gpt":0.23679666266455499,"score_spread":0.22533661257886145,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1968725397","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00039488298,0.99319756,0.0019301157,0.00076604437,0.0016566571,0.000009406413,0.000019618448,0.000026594184,0.00199918],"genre_scores_gemma":[0.001815661,0.990764,0.0014476429,0.0006236818,0.0013200336,0.000015901656,0.000052355677,0.0000043732853,0.003956186],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99986935,0.000016671955,0.000018936193,0.000031943477,0.000047499238,0.00001550218],"domain_scores_gemma":[0.99986184,0.000047710262,0.000021362453,0.0000076168353,0.000041995318,0.000019533847],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900052,0.0013164688,0.0014057845,0.0011140561,0.00032474377,0.00091224984,0.0010997541,0.0015045688,0.0018592125],"category_scores_gemma":[0.00037406923,0.0003385799,0.0003124615,0.0013700201,0.0007768002,0.0019052732,0.00063263654,0.0019541988,0.0027223222],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024137681,0.00008038895,0.0002263524,0.0072232243,0.00009069829,0.0015877951,0.000067705965,0.00055996695,0.022705024,0.010970397,0.058114193,0.8981329],"study_design_scores_gemma":[0.000026621334,0.00006145766,0.00030345636,0.00039632944,0.000063217485,0.0021854478,0.000029079589,0.00012312831,0.0041573946,0.0021206979,0.9905186,0.00001465121],"about_ca_topic_score_codex":0.00062505563,"about_ca_topic_score_gemma":0.0012882057,"teacher_disagreement_score":0.0018592125,"about_ca_system_score_codex":0.0006254889,"about_ca_system_score_gemma":0.0006786133,"threshold_uncertainty_score":0.006219685},"labels":[],"label_agreement":null},{"id":"W1969083157","doi":"10.1016/j.vph.2006.08.364","title":"Endothelin inhibits carbonic anhydrase IV via P38 in an in vitro vascular calcification model","year":2006,"lang":"en","type":"article","venue":"Vascular Pharmacology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Université de Montréal","funders":"","keywords":"Carbonic anhydrase; In vitro; Calcification; Chemistry; Endothelin 1; Endothelin receptor; Biochemistry; Internal medicine; Medicine; Enzyme; Receptor","score_opus":0.009992011419519222,"score_gpt":0.2583341594117288,"score_spread":0.2483421479922096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1969083157","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9861601,0.0028379962,0.0064688725,0.00043257538,0.00021663524,0.000104301784,0.00034631125,0.00028360655,0.0031496324],"genre_scores_gemma":[0.987017,0.001577696,0.004245418,0.00006755306,0.000115434785,0.000083094375,0.00042228217,0.0000600228,0.0064114537],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99923015,0.00018856628,0.000074064155,0.00009791352,0.00020537291,0.00020396832],"domain_scores_gemma":[0.9990544,0.0003241755,0.00019471455,0.00016772898,0.00007885221,0.000180154],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074006076,0.000897121,0.0008704131,0.0007022182,0.0006822645,0.00050084165,0.0009373168,0.0006985409,0.001899842],"category_scores_gemma":[0.0007335306,0.00053487153,0.0006864743,0.0006237553,0.0008044342,0.00059637823,0.0004334098,0.001680041,0.00039057594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019663777,0.000298218,0.00017329777,0.000073033516,0.000024503746,0.00032231153,0.000070465445,0.00018267082,0.9949616,0.00027714676,0.00012702859,0.001523301],"study_design_scores_gemma":[0.00011124693,0.00077306334,0.00080803834,0.0000030216554,0.00003115803,0.00014776948,0.000019057477,0.0007692377,0.9966047,0.00004421246,0.0006823122,0.0000062517793],"about_ca_topic_score_codex":0.004626592,"about_ca_topic_score_gemma":0.0067149727,"teacher_disagreement_score":0.004626592,"about_ca_system_score_codex":0.0009873111,"about_ca_system_score_gemma":0.00080411305,"threshold_uncertainty_score":0.009199321},"labels":[],"label_agreement":null},{"id":"W1970221679","doi":"10.1016/j.bmc.2011.01.016","title":"Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","keywords":"Chemistry; Carbonic anhydrase; Docking (animal); Active site; Stereochemistry; Coumarin; Isozyme; Enzyme; Binding site; Prodrug; Carbonic anhydrase II; Biochemistry; Organic chemistry","score_opus":0.035444771485670774,"score_gpt":0.2689398148422286,"score_spread":0.23349504335655785,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970221679","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97944415,0.0021965122,0.01339563,0.00013778509,0.0000338019,0.00004294949,0.00041658833,0.00014548135,0.0041871383],"genre_scores_gemma":[0.9927053,0.0010157052,0.0038844186,0.000023629236,0.0000028612228,0.000011816573,0.00045433163,0.00001546705,0.0018864237],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999052,0.000013635568,0.0000033791816,0.000015083644,0.000033952183,0.000028705024],"domain_scores_gemma":[0.99988234,0.00004703726,0.000026284675,0.000006261254,0.000016852893,0.000021241101],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016573146,0.00045691765,0.0004738945,0.00014514485,0.0001624564,0.00036269275,0.00047320838,0.00021969451,0.0020199614],"category_scores_gemma":[0.0003429503,0.00015771332,0.00027008617,0.00025106038,0.00019549661,0.0002493081,0.00013669938,0.000505976,0.00039526704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0038062627,0.0011852178,0.0062646437,0.0006761406,0.00034451252,0.00054083846,0.00016611458,0.095001504,0.8219632,0.0052456744,0.0027204833,0.062085398],"study_design_scores_gemma":[0.00036474096,0.0034117934,0.005304025,0.00003638913,0.00021785327,0.0005542814,0.00008315316,0.21712989,0.76715344,0.0007189875,0.0049386737,0.00008680535],"about_ca_topic_score_codex":0.0041565024,"about_ca_topic_score_gemma":0.00525832,"teacher_disagreement_score":0.0041565024,"about_ca_system_score_codex":0.00048719582,"about_ca_system_score_gemma":0.00038321142,"threshold_uncertainty_score":0.008264601},"labels":[],"label_agreement":null},{"id":"W1971386501","doi":"10.1074/jbc.m609679200","title":"Tautomerism of Histidine 64 Associated with Proton Transfer in Catalysis of Carbonic Anhydrase","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Tautomer; Histidine; Carbonic anhydrase; Chemistry; Proton; Catalysis; Stereochemistry; Biochemistry; Enzyme; Physics","score_opus":0.010507270610904076,"score_gpt":0.22975665082720012,"score_spread":0.21924938021629603,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971386501","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9991628,0.0001129958,0.00046528585,0.000014117977,0.0000022845747,0.000001870882,0.000009783333,0.000013485646,0.00021742367],"genre_scores_gemma":[0.9996117,0.00004080414,0.00022289815,0.0000036026272,7.856972e-7,0.0000016033281,0.000016401773,0.0000027228207,0.00009951504],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999484,0.000009624385,0.000002217274,0.000017410019,0.000010529912,0.000011859247],"domain_scores_gemma":[0.9999021,0.000026701342,0.000031409618,0.000005253786,0.0000117693535,0.000022618147],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016611275,0.0001766444,0.0001260379,0.00011923668,0.00015517519,0.00017611496,0.00023649001,0.0002656494,0.00047894713],"category_scores_gemma":[0.0004019762,0.0001263891,0.000112432375,0.00010905591,0.00033496032,0.00026196893,0.00010718642,0.00022441892,0.00009350421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004921888,0.00003190253,0.003461228,0.000057576843,0.000018442355,0.00018577953,0.00010811753,0.0013721011,0.99076384,0.00029675537,0.00005953083,0.0031526682],"study_design_scores_gemma":[0.00009702683,0.0005606062,0.04415118,0.000015870026,0.000053615153,0.0005610566,0.00015009734,0.029395701,0.9228959,0.0010080279,0.0010715659,0.0000393806],"about_ca_topic_score_codex":0.0012724804,"about_ca_topic_score_gemma":0.001046305,"teacher_disagreement_score":0.0012724804,"about_ca_system_score_codex":0.000702643,"about_ca_system_score_gemma":0.0001434139,"threshold_uncertainty_score":0.0050981045},"labels":[],"label_agreement":null},{"id":"W1972668078","doi":"10.1038/bjc.2013.533","title":"The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma","year":2013,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Health Services; University of Calgary","funders":"","keywords":"Immunohistochemistry; Hypoxia (environmental); Stromal cell; Cancer research; Proliferation Marker; Pathology; Univariate analysis; Internal medicine; Biology; Medicine; Oncology; Multivariate analysis","score_opus":0.004195678493158846,"score_gpt":0.23103135046292828,"score_spread":0.22683567196976942,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972668078","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99883515,0.0007369349,0.00008568309,0.000019580639,0.0000032131236,0.0000041351936,0.000060651077,0.000005325471,0.00024938377],"genre_scores_gemma":[0.9996947,0.00009557637,0.000071723065,0.000003988593,0.0000044470694,0.0000019814709,0.000069060035,9.228933e-7,0.000057676298],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9998596,0.000020029138,0.000015487149,0.000021433889,0.000051289895,0.00003216166],"domain_scores_gemma":[0.9992655,0.0001380028,0.00025769608,0.000027006974,0.00015313266,0.00015868446],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004052026,0.00021274916,0.00023774541,0.0009160536,0.00024850052,0.00050660694,0.00020471898,0.00031218602,0.0012255452],"category_scores_gemma":[0.0010291468,0.00010569976,0.00015426597,0.0005840801,0.00029163132,0.00023451341,0.0003904611,0.00021527616,0.00023885054],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00070402666,0.000018400066,0.98267764,0.00003636618,0.000051725518,0.00016481566,0.000043546705,0.00011369553,0.009094091,0.000013692728,0.0000773368,0.0070047122],"study_design_scores_gemma":[0.000010652757,0.00019607935,0.99604815,0.000008469605,0.00007829844,0.001090598,0.00014918849,0.00054004707,0.0016109745,0.000052238847,0.00020986046,0.000005525249],"about_ca_topic_score_codex":0.001271711,"about_ca_topic_score_gemma":0.0029900868,"teacher_disagreement_score":0.001271711,"about_ca_system_score_codex":0.00030337632,"about_ca_system_score_gemma":0.00025532438,"threshold_uncertainty_score":0.0040997863},"labels":[],"label_agreement":null},{"id":"W1973469475","doi":"10.1021/jm101541x","title":"Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":514,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Chemistry; Carbonic anhydrase; Transmembrane protein; Gene isoform; Cytosol; Moiety; Enzyme; Biochemistry; Stereochemistry; Receptor; Gene","score_opus":0.022160245568642552,"score_gpt":0.2452616319893131,"score_spread":0.22310138642067057,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973469475","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99083346,0.004688912,0.0016394566,0.00006473315,0.00002384772,0.00005625969,0.00026468598,0.00007667929,0.0023519883],"genre_scores_gemma":[0.99031633,0.0045418614,0.0020766412,0.000036123645,0.000016438316,0.00003380859,0.0004951654,0.000010900663,0.002472776],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999534,0.000010552664,0.0000033367965,0.0000055081773,0.000012378682,0.000014792415],"domain_scores_gemma":[0.99994934,0.000009431916,0.000013627798,0.000003917215,0.0000074798904,0.000016238773],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011068134,0.00030266333,0.0002602497,0.0001504097,0.000093577364,0.00009119349,0.000213488,0.00015902513,0.0007691497],"category_scores_gemma":[0.00009861083,0.00009933916,0.00012216457,0.00013570623,0.00010959383,0.000103744154,0.00007508829,0.00023762033,0.00017555332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020454297,0.00006242928,0.00014376704,0.000058950576,0.000008971218,0.000061278915,0.000015645215,0.0002894941,0.9950594,0.000098997436,0.00007815539,0.0039183944],"study_design_scores_gemma":[0.00006931325,0.0026535045,0.0023088274,0.0000045985876,0.000023765271,0.00021630655,0.000009726682,0.0006747806,0.9911713,0.000023392207,0.0028386577,0.0000057706393],"about_ca_topic_score_codex":0.0011531415,"about_ca_topic_score_gemma":0.0032485565,"teacher_disagreement_score":0.0011531415,"about_ca_system_score_codex":0.00020466803,"about_ca_system_score_gemma":0.00016391983,"threshold_uncertainty_score":0.0025730133},"labels":[],"label_agreement":null},{"id":"W1974807435","doi":"10.1186/1471-2148-10-176","title":"Evidence for an early evolutionary emergence of γ-type carbonic anhydrases as components of mitochondrial respiratory complex I","year":2010,"lang":"en","type":"article","venue":"BMC Evolutionary Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts","keywords":"Biology; Phylogenetics; Mitochondrial DNA; Genome; Protist; Evolutionary biology; Algae; Lineage (genetic); Mitochondrion; Protein superfamily; Homologous chromosome; Red algae; Gene; Genetics; Green algae; Biochemistry; Botany","score_opus":0.10102257225598277,"score_gpt":0.3413644105358583,"score_spread":0.24034183827987554,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974807435","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9796412,0.0090882145,0.004186835,0.00052331865,0.000055134296,0.000029362755,0.00043415892,0.00007073553,0.0059710382],"genre_scores_gemma":[0.9907314,0.0030893225,0.0040202453,0.00019802619,0.00007894226,0.000009960701,0.0006588182,0.000010023766,0.0012033959],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987376,0.000007968201,0.00000699576,0.000047180623,0.000036170015,0.000027919144],"domain_scores_gemma":[0.99901366,0.00014767757,0.0003074635,0.000062235296,0.00024537544,0.00022363751],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024196254,0.0002745209,0.00013888368,0.00063324283,0.00034392174,0.00044417623,0.00037727415,0.00044665948,0.0014228718],"category_scores_gemma":[0.0005699079,0.000121088065,0.00019094457,0.00047862015,0.0004805223,0.0003478825,0.000359175,0.00056547404,0.00038215998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037516854,0.000037793456,0.11041105,0.0004862806,0.0000707165,0.0012475149,0.00034294752,0.000114341725,0.8668915,0.0012248858,0.00030004585,0.018497907],"study_design_scores_gemma":[0.000015867063,0.00014964132,0.9107421,0.00007794433,0.000084938096,0.0035338886,0.00032459263,0.00061161205,0.067998536,0.0005777521,0.015862731,0.000020467269],"about_ca_topic_score_codex":0.0025541368,"about_ca_topic_score_gemma":0.0034951747,"teacher_disagreement_score":0.0025541368,"about_ca_system_score_codex":0.000386769,"about_ca_system_score_gemma":0.00039047652,"threshold_uncertainty_score":0.0050784945},"labels":[],"label_agreement":null},{"id":"W1975763169","doi":"10.1093/emboj/19.7.1407","title":"The active site architecture of Pisum sativum β‐carbonic anhydrase is a mirror image of that of α‐carbonic anhydrases","year":2000,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":287,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Medical Research Council Canada; National Science Council","keywords":"Biology; Pisum; Carbonic anhydrase; Biochemistry; Alpha (finance); BETA (programming language); Sativum; Active site; Enzyme; Botany","score_opus":0.007022061494378902,"score_gpt":0.2340265776470876,"score_spread":0.2270045161527087,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975763169","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98054975,0.001060374,0.012988685,0.0002881495,0.000047543515,0.000017332422,0.00021772498,0.00028172322,0.0045486344],"genre_scores_gemma":[0.9923464,0.0005587324,0.0037859287,0.0000962437,0.000015486707,0.000009969576,0.00043717318,0.000024110841,0.0027258957],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999664,0.0000022438599,0.0000014177986,0.0000091785905,0.000013881745,0.0000068925183],"domain_scores_gemma":[0.99995077,0.000004193676,0.000011062243,0.000008912843,0.000009281655,0.000015699634],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004947744,0.00020316704,0.00018978852,0.00007344853,0.0002459309,0.00045446964,0.00030126478,0.00029191587,0.000600375],"category_scores_gemma":[0.000071389804,0.00020870731,0.00018991741,0.00007638669,0.00024267068,0.00027824735,0.00011488834,0.00048390325,0.0003948795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000047198562,0.000003152838,0.00009825698,0.000017297702,0.0000029557393,0.000047381847,0.000013192618,0.00014039874,0.9972441,0.0008702041,0.000054745757,0.0014611494],"study_design_scores_gemma":[0.00004040225,0.0002716508,0.023843728,0.000009218874,0.000029419902,0.0011941851,0.000094103925,0.0056363554,0.9544722,0.0020814321,0.01230464,0.000022610306],"about_ca_topic_score_codex":0.0015136128,"about_ca_topic_score_gemma":0.0015689274,"teacher_disagreement_score":0.0015136128,"about_ca_system_score_codex":0.00025115663,"about_ca_system_score_gemma":0.0002631204,"threshold_uncertainty_score":0.0030095577},"labels":[],"label_agreement":null},{"id":"W1976250919","doi":"10.1016/j.ces.2012.01.019","title":"CO2 hydration by immobilized carbonic anhydrase in Robinson–Mahoney and packed-bed scrubbers—Role of mass transfer and inhibitor removal","year":2012,"lang":"en","type":"article","venue":"Chemical Engineering Science","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Packed bed; Mass transfer; Carbonic anhydrase; Scrubber; Kinetics; Immobilized enzyme; Chromatography; Bicarbonate; Catalysis; Absorption (acoustics); Chemical engineering; Enzyme; Organic chemistry; Materials science","score_opus":0.0030459299763924484,"score_gpt":0.18912193278781722,"score_spread":0.18607600281142478,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1976250919","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9941977,0.0009880847,0.004079169,0.00005083853,0.000022741558,0.000013076153,0.00003944422,0.000074620264,0.0005342988],"genre_scores_gemma":[0.99548775,0.00034936704,0.0030818863,0.000023027624,0.000008588675,0.0000112797425,0.000104835846,0.000030377394,0.0009029193],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997031,0.000044773995,0.000022145507,0.00006303495,0.00009015006,0.00007676151],"domain_scores_gemma":[0.9998267,0.000059404367,0.000034035296,0.000019206793,0.000022389413,0.000038190497],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034638814,0.00035390272,0.0005483044,0.00015016738,0.00021055074,0.0005051642,0.000651163,0.00037752002,0.00048025695],"category_scores_gemma":[0.00036514504,0.00028749256,0.00025125768,0.00015562313,0.00031058415,0.00044569568,0.00027719644,0.00050490594,0.00029139867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009755784,0.000017763026,0.00010151009,0.000031950953,0.000008591957,0.000028657532,0.000024566147,0.0001653584,0.99872893,0.000050102226,0.00002039859,0.00072472484],"study_design_scores_gemma":[0.000006975473,0.000048754107,0.0006843459,0.0000018346498,0.0000062823965,0.000026727483,0.000010795872,0.0028184145,0.996097,0.0000109015045,0.00028258117,0.00000528335],"about_ca_topic_score_codex":0.0018504524,"about_ca_topic_score_gemma":0.00377181,"teacher_disagreement_score":0.0018504524,"about_ca_system_score_codex":0.0004299675,"about_ca_system_score_gemma":0.0002455876,"threshold_uncertainty_score":0.0036793351},"labels":[],"label_agreement":null},{"id":"W1977641230","doi":"10.1021/bi0015111","title":"Localization of the Cl<sup>-</sup>/HCO<sub>3</sub><sup>-</sup> Anion Exchanger Binding Site to the Amino-Terminal Region of Carbonic Anhydrase II","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Carbonic anhydrase II; Histidine; Chemistry; Binding site; Amino acid; Peptide sequence; Carbonic anhydrase; Lysine; Mutant; Biochemistry; Bicarbonate; Gene isoform; Stereochemistry; Enzyme","score_opus":0.00804048964911889,"score_gpt":0.2095640759038867,"score_spread":0.20152358625476782,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977641230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9967998,0.0006852253,0.0016688175,0.00006350647,0.000008832616,0.0000067635724,0.0001422934,0.00001010727,0.00061474065],"genre_scores_gemma":[0.995083,0.00038601583,0.0022884482,0.00006385668,0.000010998151,0.000010518164,0.00053673476,0.000011668635,0.0016088303],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999287,0.000009690599,0.0000048373654,0.000016180546,0.00001987976,0.000020614629],"domain_scores_gemma":[0.9998677,0.000019349736,0.000036167276,0.000013702842,0.000024074523,0.000039071667],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000081011814,0.00014561479,0.00012986503,0.000082689105,0.00012684512,0.00019992118,0.00015584721,0.00020123908,0.0011008264],"category_scores_gemma":[0.000105764375,0.000116871415,0.00025775318,0.000071090006,0.0002148949,0.00013864008,0.00014744175,0.00030563408,0.0007551792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005148032,0.000005085977,0.00030958146,0.000015959211,0.000002367984,0.00004079367,0.0000125695005,0.00002668549,0.9992132,0.000066971035,0.000010574329,0.00024472422],"study_design_scores_gemma":[0.000019966457,0.00015441315,0.049307328,0.000018088493,0.00001744128,0.0006728517,0.000109735956,0.0016478496,0.9451825,0.00008548201,0.0027768705,0.0000074827894],"about_ca_topic_score_codex":0.001230561,"about_ca_topic_score_gemma":0.0011240152,"teacher_disagreement_score":0.001230561,"about_ca_system_score_codex":0.00038639607,"about_ca_system_score_gemma":0.0002983419,"threshold_uncertainty_score":0.003682673},"labels":[],"label_agreement":null},{"id":"W1978633908","doi":"10.1042/bj20031711","title":"Complementation of the yeast deletion mutant DeltaNCE103 by members of the beta class of carbonic anhydrases is dependent on carbonic anhydrase activity rather than on antioxidant activity","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Complementation; Yeast; Biochemistry; Escherichia coli; Mutant; Mutagenesis; Recombinant DNA; Saccharomyces cerevisiae; Biology; Chemistry; Gene","score_opus":0.010222485363786147,"score_gpt":0.24461512090916968,"score_spread":0.23439263554538353,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1978633908","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.990774,0.00028328795,0.0053646048,0.00012944994,0.00004704302,0.000051613948,0.001222904,0.00015242955,0.001974729],"genre_scores_gemma":[0.98496664,0.00041019768,0.0064398698,0.00005063929,0.0000050518483,0.000048336486,0.0024306548,0.00009633975,0.0055523007],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998704,0.00000848051,0.00001981032,0.000029199513,0.000053977958,0.000018160084],"domain_scores_gemma":[0.9997919,0.00003671034,0.000049347174,0.000035003268,0.000030509027,0.00005648258],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009121801,0.0004630348,0.00030029638,0.00015807089,0.00014428972,0.00023378003,0.00036679496,0.00018735851,0.0016632155],"category_scores_gemma":[0.00015309703,0.00014500598,0.00021849899,0.00022230124,0.00018974401,0.00010283005,0.00023464223,0.0006287942,0.00057282846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000459654,0.000020476717,0.00017142574,0.000019404704,0.000003853373,0.00007224031,0.000007641628,0.000045783447,0.99845123,0.00008235709,0.000028686829,0.0010510574],"study_design_scores_gemma":[0.000016772201,0.0000783567,0.0037386457,0.000005042531,0.000010225291,0.00052802905,0.000036629383,0.0010123057,0.9922472,0.000037182977,0.0022836889,0.000005944835],"about_ca_topic_score_codex":0.002626495,"about_ca_topic_score_gemma":0.0037625402,"teacher_disagreement_score":0.002626495,"about_ca_system_score_codex":0.00031868424,"about_ca_system_score_gemma":0.00039390722,"threshold_uncertainty_score":0.0055639744},"labels":[],"label_agreement":null},{"id":"W1978792081","doi":"10.4161/cc.25843","title":"Identifying the stromal cell type that contributes to tumor aggressiveness associated with carbonic anhydrase IX","year":2013,"lang":"en","type":"letter","venue":"Cell Cycle","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Health Services; Calgary Laboratory Services; University of Calgary","funders":"","keywords":"Biology; Carbonic anhydrase; Stromal cell; Cancer research; Epithelial–mesenchymal transition; Mesenchymal stem cell; Cell; Enzyme; Cell biology; Biochemistry; Transition (genetics); Gene","score_opus":0.01125043594315758,"score_gpt":0.21202034619104804,"score_spread":0.20076991024789045,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1978792081","genre_codex":"commentary","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.3195609,0.018010663,0.026460929,0.4966076,0.0253191,0.00055097055,0.0009051967,0.0017509382,0.11083376],"genre_scores_gemma":[0.7813317,0.011504651,0.018119428,0.050903104,0.023656594,0.00036963023,0.000554494,0.00015105597,0.11340936],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998,0.00003268838,0.00002282121,0.000031917723,0.00006746159,0.000045219836],"domain_scores_gemma":[0.9996414,0.00017612295,0.000044192195,0.000029818952,0.00005443742,0.000054014254],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023280288,0.0002686403,0.00032281698,0.00028043173,0.00036153628,0.00045588744,0.00024427238,0.0020740724,0.007808637],"category_scores_gemma":[0.0007552667,0.00014752655,0.00023726172,0.00012926102,0.0003701866,0.00024772531,0.00016458391,0.0017956123,0.0021942528],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022743426,0.00039250276,0.01602007,0.00075979886,0.000073586096,0.09763033,0.00023703305,0.0003948598,0.33609155,0.013129449,0.38808602,0.14491045],"study_design_scores_gemma":[0.00037130096,0.0006054782,0.024033245,0.00015430008,0.00014031562,0.20383178,0.0003207684,0.007580719,0.24429098,0.008050025,0.51056844,0.0000526425],"about_ca_topic_score_codex":0.00044004718,"about_ca_topic_score_gemma":0.0008318171,"teacher_disagreement_score":0.007808637,"about_ca_system_score_codex":0.0006433167,"about_ca_system_score_gemma":0.00018818297,"threshold_uncertainty_score":0.02612245},"labels":[],"label_agreement":null},{"id":"W1979276629","doi":"10.1038/sj.bjc.6600796","title":"Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma","year":2003,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency; University of Manitoba","funders":"Medical Research and Materiel Command; Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Breast cancer; Immunohistochemistry; Hypoxia (environmental); Biology; Univariate analysis; Internal medicine; Carcinoma; Pathology; Cancer research; Carbonic anhydrase; Mammary gland; Cancer; Oncology; Medicine; Enzyme; Multivariate analysis; Chemistry","score_opus":0.006357992248124134,"score_gpt":0.22729281655223796,"score_spread":0.22093482430411382,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979276629","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99795157,0.0010413083,0.0002040651,0.00003169818,0.000006085743,0.0000049909368,0.00006112677,0.000007447347,0.0006918351],"genre_scores_gemma":[0.9994642,0.00017187973,0.000087693275,0.0000062842637,0.000009129783,0.0000023887683,0.000075250064,0.000001097688,0.00018190738],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9998418,0.000030775667,0.00001668325,0.00002773776,0.000052419862,0.000030543855],"domain_scores_gemma":[0.99927884,0.0002169938,0.0002490424,0.000053354663,0.00008498644,0.00011675021],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033054576,0.00012952532,0.00024712327,0.0005163752,0.00015844633,0.00026172353,0.00014594076,0.00026519466,0.0011634234],"category_scores_gemma":[0.001305128,0.00009661089,0.00011902529,0.0004713426,0.00025697483,0.00013720777,0.00018375846,0.00020499965,0.00025736788],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040848862,0.000017207642,0.98717284,0.000023285846,0.000024087924,0.0004030175,0.00005078937,0.00006227552,0.0070397086,0.00001394243,0.00009394118,0.004690369],"study_design_scores_gemma":[0.0000031518803,0.00008623709,0.9972113,0.000002890974,0.000017074954,0.0016483628,0.000041456162,0.00013444484,0.00063946587,0.000020006131,0.0001937134,0.0000018362713],"about_ca_topic_score_codex":0.0009997345,"about_ca_topic_score_gemma":0.0013353085,"teacher_disagreement_score":0.0011634234,"about_ca_system_score_codex":0.00020728042,"about_ca_system_score_gemma":0.00012937866,"threshold_uncertainty_score":0.003892064},"labels":[],"label_agreement":null},{"id":"W1979380576","doi":"10.1016/j.ijggc.2013.01.044","title":"Enzymatic CO2 capture by immobilized hCA II in an intensified microreactor—Kinetic study of the catalytic hydration","year":2013,"lang":"en","type":"article","venue":"International journal of greenhouse gas control","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Microreactor; Chemistry; Immobilized enzyme; Catalysis; Carbonic anhydrase II; Covalent bond; Enzyme kinetics; Aqueous solution; Enzyme catalysis; Chemical engineering; Chromatography; Esterase; Enzyme; Carbonic anhydrase; Combinatorial chemistry; Organic chemistry; Active site","score_opus":0.006387953144171471,"score_gpt":0.22773071343919174,"score_spread":0.22134276029502026,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979380576","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930239,0.00062631216,0.005339225,0.00007727204,0.000026216074,0.00001976281,0.000113205766,0.00011163641,0.00066245504],"genre_scores_gemma":[0.99512094,0.00027119723,0.0033977607,0.000025698619,0.000010543131,0.000018576548,0.00010989622,0.000022187254,0.0010231587],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977356,0.000023465765,0.000009119423,0.000075175856,0.0000465841,0.000071997376],"domain_scores_gemma":[0.9998381,0.000071920425,0.00002254716,0.000018523597,0.000017810606,0.000031109117],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000432326,0.0004845552,0.0005687534,0.0001472223,0.00020003883,0.00061133824,0.0007348291,0.00041080097,0.00082414434],"category_scores_gemma":[0.00032770363,0.00032217315,0.000278014,0.00021661427,0.0005236844,0.00045229908,0.00030842188,0.0008023454,0.00028027536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011412187,0.0000136044355,0.00013316875,0.000021383747,0.000007144354,0.000026380232,0.000022260063,0.000101345984,0.9988036,0.000062662155,0.000019814204,0.0006745853],"study_design_scores_gemma":[0.000011414927,0.00008898161,0.0011436618,0.0000019900858,0.0000068425943,0.000026210591,0.000018579818,0.0024368851,0.9959209,0.000013830794,0.00032326597,0.000007444465],"about_ca_topic_score_codex":0.002893963,"about_ca_topic_score_gemma":0.00267683,"teacher_disagreement_score":0.002893963,"about_ca_system_score_codex":0.0005918392,"about_ca_system_score_gemma":0.00037902503,"threshold_uncertainty_score":0.005754292},"labels":[],"label_agreement":null},{"id":"W1979913254","doi":"10.1631/jzus.b1200297","title":"Immunocytochemical localization of carbonic anhydrase in the pseudobranch tissue of the rainbow trout Oncorhynchus my-kiss","year":2014,"lang":"en","type":"article","venue":"Journal of Zhejiang University SCIENCE B","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"","keywords":"Rainbow trout; Biology; Immunocytochemistry; Immunostaining; Immunoperoxidase; Anatomy; Connective tissue; Trout; Immunohistochemistry; Endocrinology; Antibody; Fish <Actinopterygii>; Immunology; Monoclonal antibody","score_opus":0.004799455500349362,"score_gpt":0.21203009146378138,"score_spread":0.20723063596343202,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979913254","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9950895,0.0009938738,0.0019428306,0.00006484247,0.000026357235,0.000019138137,0.00028974673,0.00004232615,0.0015314599],"genre_scores_gemma":[0.9908393,0.0008838642,0.0032964014,0.00004184017,0.000018374429,0.000031681568,0.00061612227,0.000015953874,0.0042564184],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9999453,0.000002038256,0.0000040694676,0.000020132891,0.000011830733,0.00001672262],"domain_scores_gemma":[0.9999157,0.000006165899,0.00001961955,0.000006377547,0.000024186005,0.000027872455],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000056268127,0.00021092668,0.0001568628,0.00036794457,0.00027935233,0.00018658853,0.00013027196,0.00020519758,0.0007604043],"category_scores_gemma":[0.00007005538,0.00015928327,0.00018690048,0.000111469155,0.0002688981,0.00027430477,0.00025116524,0.00023553094,0.0002488792],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00002944083,0.0000030945557,0.0016083709,0.00003060229,0.0000038309436,0.00007559008,0.000043165863,0.000011308216,0.9976846,0.000098261306,0.000016006165,0.00039564844],"study_design_scores_gemma":[0.00006003993,0.0005084889,0.49064782,0.00004245115,0.00009125307,0.0017353764,0.00083298265,0.0018003943,0.49713853,0.0004635632,0.006638008,0.00004111902],"about_ca_topic_score_codex":0.0056282473,"about_ca_topic_score_gemma":0.0121071525,"teacher_disagreement_score":0.0056282473,"about_ca_system_score_codex":0.00029449826,"about_ca_system_score_gemma":0.0003396246,"threshold_uncertainty_score":0.0111910105},"labels":[],"label_agreement":null},{"id":"W1980370145","doi":"10.1016/j.resp.2006.03.007","title":"The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebrates","year":2006,"lang":"en","type":"review","venue":"Respiratory Physiology & Neurobiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"","keywords":"Isozyme; Carbonic anhydrase; Biochemistry; Biology; Gill; Respiratory system; Carbon dioxide; Respiration; Enzyme; Chemistry; Anatomy; Ecology","score_opus":0.01568332428212177,"score_gpt":0.25807285261204604,"score_spread":0.24238952832992428,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1980370145","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000321909,0.99811554,0.000467576,0.00014759394,0.00016673192,0.000003939593,0.000021099282,0.000007543217,0.00074811873],"genre_scores_gemma":[0.00090999383,0.99739814,0.00055950927,0.00006286252,0.00018345726,0.000003539409,0.000042722564,0.000001383831,0.00083841715],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.999863,0.000009637798,0.000021057434,0.000033290653,0.000060752413,0.00001208112],"domain_scores_gemma":[0.99976784,0.000059569982,0.000050344017,0.00000939515,0.000081921775,0.00003106812],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046174182,0.0009656666,0.0013696548,0.0013308902,0.000280669,0.00093689136,0.0015587728,0.0010350345,0.0018150831],"category_scores_gemma":[0.0004531464,0.00038039478,0.00030100238,0.002563286,0.0006404665,0.0012616322,0.000588588,0.0013202815,0.0015652024],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000102742524,0.00003576,0.0002892363,0.007960085,0.000052910676,0.00026321984,0.00008453836,0.0007372066,0.012840882,0.0037642904,0.014827794,0.95904136],"study_design_scores_gemma":[0.000018081422,0.00007734413,0.0019569837,0.0014244646,0.00012056402,0.0017189707,0.000064080785,0.00018533219,0.0025528127,0.0028180617,0.9890372,0.000026104004],"about_ca_topic_score_codex":0.0021031979,"about_ca_topic_score_gemma":0.0032686202,"teacher_disagreement_score":0.0021031979,"about_ca_system_score_codex":0.00082355994,"about_ca_system_score_gemma":0.0012690454,"threshold_uncertainty_score":0.0060720444},"labels":[],"label_agreement":null},{"id":"W1982209500","doi":"10.1158/1538-7445.am10-455","title":"Abstract 455: Hypoxia induced carbonic anhydrase IX is essential for the growth and metastasis of breast tumors","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Centre for Advancing Health Outcomes; Child and Family Research Institute; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Cancer research; Metastasis; Breast cancer; Metastatic breast cancer; Tumor hypoxia; Pathology; Cancer; Medicine; Primary tumor; Anoikis; Biology; Internal medicine; Radiation therapy","score_opus":0.03456146393820839,"score_gpt":0.3519949284551389,"score_spread":0.31743346451693055,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982209500","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97813237,0.00407107,0.0052375244,0.00048375447,0.000102021884,0.0000666957,0.0036529778,0.00035302786,0.007900677],"genre_scores_gemma":[0.96822363,0.0017186787,0.0033142937,0.00013525962,0.00003609171,0.000052239902,0.004960891,0.00006665229,0.021492226],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999325,0.0000059369277,0.0000049264318,0.000016415303,0.000024998522,0.000015166607],"domain_scores_gemma":[0.99993336,0.000004780214,0.000023095678,0.000004990572,0.000009809794,0.000023906177],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000062072155,0.00020097924,0.00016109295,0.00013130033,0.00016254133,0.00020634102,0.000120239965,0.00019838329,0.0041369726],"category_scores_gemma":[0.000065014836,0.00009231323,0.00016360161,0.00011877937,0.000100742815,0.00010032867,0.00013602427,0.00029303238,0.0012141556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003828946,0.0000062189506,0.00013449375,0.000016779097,0.0000014561626,0.000029765823,0.000002918705,0.000010862025,0.9990363,0.00004162831,0.0000719215,0.0006092974],"study_design_scores_gemma":[0.000023495584,0.00022132312,0.0270279,0.000011738614,0.000015590027,0.0007682211,0.00002025332,0.0006051356,0.96052206,0.00007688726,0.010703263,0.0000040840882],"about_ca_topic_score_codex":0.0014909728,"about_ca_topic_score_gemma":0.001153097,"teacher_disagreement_score":0.0041369726,"about_ca_system_score_codex":0.00039319025,"about_ca_system_score_gemma":0.00025283097,"threshold_uncertainty_score":0.0138396025},"labels":[],"label_agreement":null},{"id":"W1982792443","doi":"10.1158/1078-0432.ccr-03-0541","title":"Carbonic Anhydrase IX as a Marker for Poor Prognosis in Soft Tissue Sarcoma","year":2004,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada); Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Sarcoma; Pathology; Soft tissue sarcoma; Soft tissue; Metastasis; Stroma; Immunohistochemistry; Medicine; Internal medicine; Cancer","score_opus":0.10740427588394963,"score_gpt":0.48592295641640376,"score_spread":0.37851868053245413,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982792443","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99898154,0.00039412198,0.00032685685,0.000015359401,0.0000017147427,0.0000047808544,0.000038832746,0.0000051554725,0.0002315723],"genre_scores_gemma":[0.99968827,0.000053507352,0.00015138579,0.0000028525023,0.0000027503706,0.0000026146192,0.00004629426,6.119689e-7,0.000051737654],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.999892,0.000027527276,0.000012855766,0.000019368339,0.000030671228,0.000017579692],"domain_scores_gemma":[0.9994661,0.00012568456,0.00023295659,0.00002625412,0.00005927278,0.00008982802],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029536994,0.00018993678,0.0001570776,0.0006316837,0.00014741799,0.00025732003,0.000107324086,0.00016985978,0.00084746524],"category_scores_gemma":[0.00075526745,0.00006695515,0.00009758913,0.00035253388,0.00030565856,0.00019919548,0.0002799944,0.0001896035,0.00013856225],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006207087,0.000016056825,0.9714947,0.0000341324,0.000031568816,0.00015332777,0.00004937631,0.00022400432,0.02163769,0.00003470087,0.0000603994,0.0056433687],"study_design_scores_gemma":[0.000011389094,0.00031168494,0.9903086,0.000010605643,0.00004234008,0.0013770682,0.00008723187,0.0011568497,0.0062993024,0.00009992164,0.00028999,0.000005008337],"about_ca_topic_score_codex":0.00044198186,"about_ca_topic_score_gemma":0.00062901503,"teacher_disagreement_score":0.00084746524,"about_ca_system_score_codex":0.000240533,"about_ca_system_score_gemma":0.00015750008,"threshold_uncertainty_score":0.0028350353},"labels":[],"label_agreement":null},{"id":"W1982970232","doi":"10.1517/13543776.2013.780598","title":"Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)","year":2013,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Patents","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":295,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McMaster University","keywords":"Carbonic anhydrase; Pharmacology; Chlorthalidone; Chemistry; Furosemide; Diuretic; Hydrochlorothiazide; Bumetanide; Drug; Acetazolamide; Medicine; Internal medicine; Blood pressure; Enzyme; Biochemistry","score_opus":0.0921937601477758,"score_gpt":0.33820708731809257,"score_spread":0.24601332717031676,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982970232","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00082102633,0.9939382,0.0001668091,0.0010084297,0.00023947888,0.000027515694,0.00042310075,0.000016032092,0.0033594107],"genre_scores_gemma":[0.0036414652,0.99437463,0.00020061951,0.0005436818,0.00022549849,0.000016696646,0.0003416036,0.000002846368,0.000652883],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9995493,0.00004931662,0.000102431695,0.00007793893,0.0001754086,0.000045486096],"domain_scores_gemma":[0.99877876,0.0005365248,0.00035019123,0.000017078077,0.0002724865,0.00004494649],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007130454,0.0007116921,0.0011418201,0.00506135,0.0003020882,0.0011627149,0.0007834892,0.0009886794,0.015560569],"category_scores_gemma":[0.002198308,0.00022802221,0.0011660462,0.0057461504,0.00035794184,0.0014330511,0.00050833914,0.00089411036,0.0025689064],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002368378,0.00007657108,0.0008137757,0.08831286,0.00026386746,0.00086317054,0.00016135817,0.0002551666,0.0015393051,0.0028498475,0.053345855,0.8512814],"study_design_scores_gemma":[0.00007080895,0.00024581468,0.0056700227,0.040336363,0.001529859,0.0042660786,0.00019938144,0.0001631599,0.0009546222,0.0016293607,0.94488823,0.00004629336],"about_ca_topic_score_codex":0.0014680834,"about_ca_topic_score_gemma":0.0022393654,"teacher_disagreement_score":0.015560569,"about_ca_system_score_codex":0.0007596372,"about_ca_system_score_gemma":0.0019818537,"threshold_uncertainty_score":0.0520553},"labels":[],"label_agreement":null},{"id":"W1983114604","doi":"10.1016/j.yjmcc.2015.03.002","title":"Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Aortic valve; Internal medicine; Acetazolamide; Calcification; Endocrinology; Medicine","score_opus":0.012807058725690846,"score_gpt":0.23651724275145203,"score_spread":0.22371018402576118,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1983114604","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9965844,0.0011287971,0.0010899073,0.00011243647,0.000055927943,0.000011724195,0.00004755246,0.00007282619,0.000896311],"genre_scores_gemma":[0.99690104,0.0003797555,0.0003475498,0.000023590026,0.000028725093,0.0000104625615,0.00010005869,0.000013919111,0.0021949792],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984944,0.000030039246,0.000011920446,0.00001826231,0.000041399995,0.00004897998],"domain_scores_gemma":[0.9998041,0.00004795556,0.000019742338,0.000030409356,0.000017298677,0.00008050868],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024746422,0.00021069674,0.00048361666,0.00015865028,0.00019696027,0.0003965818,0.00033264648,0.0002281912,0.0010501686],"category_scores_gemma":[0.0003111609,0.00013647783,0.00015345174,0.00013289828,0.00036657017,0.00012981266,0.00018984517,0.0009858824,0.00025090962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007161336,0.00008120562,0.00036758414,0.000024237544,0.0000070611327,0.00008117674,0.000022174821,0.000055961467,0.9963063,0.00012413404,0.000086817025,0.0021272385],"study_design_scores_gemma":[0.0001084258,0.0007529695,0.0064342986,0.0000038938792,0.000037002315,0.00029444194,0.000037912974,0.0010154194,0.9890688,0.000054313732,0.0021881768,0.000004187099],"about_ca_topic_score_codex":0.00090534694,"about_ca_topic_score_gemma":0.0013246704,"teacher_disagreement_score":0.0010501686,"about_ca_system_score_codex":0.00023587051,"about_ca_system_score_gemma":0.00032035506,"threshold_uncertainty_score":0.0035131574},"labels":[],"label_agreement":null},{"id":"W1983551380","doi":"10.1007/s00360-004-0426-4","title":"Evidence for a membrane-bound carbonic anhydrase in the heart of an ancient vertebrate, the sea lamprey (Petromyzon marinus)","year":2004,"lang":"en","type":"article","venue":"Journal of Comparative Physiology B","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lamprey; Petromyzon; Carbonic anhydrase; Isozyme; Biology; Vertebrate; Membrane; Differential centrifugation; Biochemistry; Cytoplasm; Enzyme; Gene","score_opus":0.05700737651039732,"score_gpt":0.333317606624273,"score_spread":0.2763102301138757,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1983551380","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99740916,0.00059390493,0.00077087723,0.000108056876,0.000011305547,0.000003416326,0.000083419895,0.000014847671,0.0010050884],"genre_scores_gemma":[0.99755293,0.00028292267,0.0007762643,0.000064532265,0.0000146469265,0.0000045164843,0.00023200543,0.000007671349,0.001064586],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994504,0.0000035489988,0.0000049824507,0.000017917973,0.00001479452,0.000013712308],"domain_scores_gemma":[0.99976295,0.000035380883,0.00005685589,0.000026543246,0.000057704005,0.000060635437],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008694331,0.00016717671,0.00026103746,0.00023641899,0.00032125917,0.00035619776,0.00041111084,0.00054774364,0.0008545765],"category_scores_gemma":[0.00024604675,0.0002460071,0.0001434273,0.00011726189,0.00067040196,0.00029464852,0.00034801653,0.0004723044,0.0002516209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001279247,0.000006101514,0.0057241623,0.000045231583,0.000011873153,0.00014590955,0.00007896507,0.000022014767,0.9922007,0.00028454835,0.000021041524,0.0013315652],"study_design_scores_gemma":[0.000043116113,0.00044344075,0.6928086,0.00003774703,0.00013096114,0.003578014,0.0004346151,0.0011602585,0.29616407,0.000637059,0.0045343554,0.00002768377],"about_ca_topic_score_codex":0.003419482,"about_ca_topic_score_gemma":0.0043273396,"teacher_disagreement_score":0.003419482,"about_ca_system_score_codex":0.00031331877,"about_ca_system_score_gemma":0.00021525705,"threshold_uncertainty_score":0.0067991614},"labels":[],"label_agreement":null},{"id":"W1984670059","doi":"10.1007/s00360-002-0269-9","title":"Characterization of erythrocyte carbonic anhydrase in an ancient fish, the longnose gar ( Lepisosteus osseus )","year":2002,"lang":"en","type":"article","venue":"Journal of Comparative Physiology B","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"","keywords":"Carbonic anhydrase; Biology; Phylogenetic tree; Isozyme; Complementary DNA; Amino acid; myr; Red blood cell; Peptide sequence; Biochemistry; Molecular biology; Zoology; Enzyme; Gene; Genome","score_opus":0.028375984382000428,"score_gpt":0.2720175324657137,"score_spread":0.24364154808371327,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984670059","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9984933,0.00036754986,0.0005615081,0.000033527976,0.000003115627,0.0000036257695,0.0001491966,0.0000048473153,0.00038322248],"genre_scores_gemma":[0.99659926,0.0002922872,0.00096471666,0.00003961952,0.000007927548,0.000006618877,0.00068847125,0.000008101671,0.0013929849],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996614,0.0000024842823,0.0000033533256,0.000012008926,0.000008974684,0.000007056534],"domain_scores_gemma":[0.9998667,0.000024871773,0.00003061937,0.000013193035,0.00002876876,0.00003581737],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008159072,0.00017277623,0.00018890675,0.0003187517,0.00015021478,0.00023135486,0.0001844983,0.00029184908,0.00040709766],"category_scores_gemma":[0.00017587768,0.00014154706,0.00015849454,0.00016932355,0.00027769877,0.00018662927,0.0001759748,0.00034785847,0.00018269676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011876369,0.00000860044,0.005481615,0.000021575283,0.000008228188,0.00009103158,0.000053645515,0.000029143872,0.9927614,0.00006581498,0.000010456483,0.0013496717],"study_design_scores_gemma":[0.000036060253,0.0004981997,0.6836571,0.000016840044,0.00010258386,0.0031100712,0.00034345873,0.0015297084,0.3063494,0.00026767515,0.0040651388,0.000023804616],"about_ca_topic_score_codex":0.003117574,"about_ca_topic_score_gemma":0.0044393777,"teacher_disagreement_score":0.003117574,"about_ca_system_score_codex":0.00017748044,"about_ca_system_score_gemma":0.00016227712,"threshold_uncertainty_score":0.0061988235},"labels":[],"label_agreement":null},{"id":"W1986213329","doi":"10.1186/1471-2261-13-2","title":"Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heart","year":2013,"lang":"en","type":"article","venue":"BMC Cardiovascular Disorders","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Consejo Nacional de Investigaciones Científicas y Técnicas; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Ventricle; Muscle hypertrophy; Brain natriuretic peptide; Heart failure; Endocrinology; Atrial natriuretic peptide; Medicine; Bicarbonate; Hypertrophic cardiomyopathy; Cardiology; Carbonic anhydrase II; Carbonic anhydrase; Chemistry; Enzyme; Biochemistry","score_opus":0.010030652550565075,"score_gpt":0.21610336462950708,"score_spread":0.206072712078942,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986213329","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99764097,0.0005744134,0.00078832544,0.000008044915,0.000004704732,0.000021230466,0.00045155417,0.0000138008645,0.0004969617],"genre_scores_gemma":[0.9938403,0.00048401428,0.0033761554,0.00003376981,0.000013472732,0.000109185916,0.0012685299,0.000010990588,0.0008635579],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.99989545,0.000009366172,0.000007666005,0.00004343473,0.000025497047,0.000018540177],"domain_scores_gemma":[0.99986637,0.000021292602,0.000037358637,0.000008089285,0.00003226578,0.000034633333],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016386062,0.00014365315,0.00013907399,0.0004987861,0.00012471626,0.00016680062,0.000082457205,0.00019012848,0.0009169059],"category_scores_gemma":[0.00014269055,0.000080906895,0.000076272845,0.0003423894,0.00022241614,0.00008188691,0.00012673704,0.00014858933,0.00014944657],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00058698555,0.000036180336,0.037964027,0.00006933649,0.00001653234,0.00016324135,0.00018297654,0.0000440627,0.95726454,0.000039309587,0.000047749352,0.0035850015],"study_design_scores_gemma":[0.000028563782,0.001099241,0.7953834,0.000019043486,0.000061763065,0.0013445339,0.00036988297,0.0010248002,0.19946681,0.00007118382,0.0011217595,0.00000895355],"about_ca_topic_score_codex":0.00029703975,"about_ca_topic_score_gemma":0.00050218427,"teacher_disagreement_score":0.0009169059,"about_ca_system_score_codex":0.0000883768,"about_ca_system_score_gemma":0.000079348945,"threshold_uncertainty_score":0.0030673146},"labels":[],"label_agreement":null},{"id":"W1990346700","doi":"10.1007/s004250100638","title":"Characterization of a mutant lacking carboxysomal carbonic anhydrase from the cyanobacterium Synechocystis PCC6803","year":2001,"lang":"en","type":"article","venue":"Planta","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Amgen (Canada); University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"RuBisCO; Mutant; Carbonic anhydrase; Biochemistry; Biology; Molecular biology; Wild type; Gene; Enzyme","score_opus":0.008392589468163104,"score_gpt":0.2025343633983642,"score_spread":0.1941417739302011,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1990346700","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9913202,0.00045556796,0.0052230703,0.00025973935,0.000067719455,0.000042532254,0.0013859147,0.00017209555,0.0010731121],"genre_scores_gemma":[0.99079084,0.00036510502,0.0031179762,0.00008380351,0.000010920624,0.000037252325,0.0025094524,0.00017567133,0.002909052],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996958,0.000020189273,0.00004076183,0.000047444097,0.00015547096,0.000040344537],"domain_scores_gemma":[0.9994654,0.00009529236,0.00014112364,0.00006822329,0.00009974522,0.00013034539],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015081497,0.0007394842,0.0004773244,0.00035055657,0.00027744973,0.0004731369,0.00050330436,0.00052161986,0.0004999988],"category_scores_gemma":[0.0004437951,0.0002611816,0.00036694953,0.00040249538,0.0003415315,0.0002268099,0.0003376493,0.00064177654,0.0005493663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000018595018,0.000009427209,0.00012965957,0.000010858384,0.0000032502383,0.00011541214,0.00001527861,0.000035473226,0.9993703,0.000034042478,0.000012514191,0.0002451823],"study_design_scores_gemma":[0.000012866943,0.00006431146,0.0061412156,0.0000047330323,0.000025248048,0.0010393478,0.00007014531,0.000796711,0.9902327,0.000037732487,0.0015601693,0.000014831017],"about_ca_topic_score_codex":0.013178175,"about_ca_topic_score_gemma":0.009592196,"teacher_disagreement_score":0.013178175,"about_ca_system_score_codex":0.0007120621,"about_ca_system_score_gemma":0.0008090521,"threshold_uncertainty_score":0.026202917},"labels":[],"label_agreement":null},{"id":"W1990391394","doi":"10.1002/jcp.22400","title":"pH control mechanisms of tumor survival and growth","year":2010,"lang":"en","type":"review","venue":"Journal of Cellular Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":353,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"CHIST-ERA; Natural Sciences and Engineering Research Council of Canada; Ligue Contre le Cancer","keywords":"Tumor microenvironment; Warburg effect; Cancer cell; Biology; Carbonic anhydrase; Context (archaeology); Intracellular pH; Phenotype; Tumor hypoxia; Cellular adaptation; Cell; Cancer; Tumor progression; Metabolism; Cancer research; Cell biology; Intracellular; Enzyme; Biochemistry; Tumor cells; Genetics; Gene; Medicine; Internal medicine","score_opus":0.01130243575155948,"score_gpt":0.24568550696639352,"score_spread":0.23438307121483404,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1990391394","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0009966935,0.99393725,0.0013230836,0.0003129998,0.00017428689,0.000009579299,0.000031259155,0.000033169534,0.00318153],"genre_scores_gemma":[0.008926539,0.9880846,0.00064341543,0.00012000704,0.0001780512,0.000025185087,0.000045111312,0.000004237983,0.0019728492],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998567,0.000021189755,0.000015450123,0.000032989472,0.000052511557,0.000020987693],"domain_scores_gemma":[0.9999181,0.000021074988,0.000017936807,0.0000050944354,0.000023580458,0.000014195152],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027201299,0.00071186613,0.0010358528,0.001050036,0.0002560643,0.00084458286,0.0008798535,0.0008064105,0.0013214112],"category_scores_gemma":[0.00019913129,0.00020099958,0.00026981416,0.0008410713,0.00071055966,0.0007901867,0.00055035553,0.0010093672,0.0013491748],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019426271,0.00008237109,0.00039554868,0.009081527,0.00007970533,0.0005310507,0.00013147983,0.0011694431,0.053770434,0.020577082,0.013215578,0.90077144],"study_design_scores_gemma":[0.000032304848,0.00020886908,0.002675076,0.0007923313,0.00007056001,0.0019939227,0.00012249293,0.0004382246,0.023931503,0.009431928,0.9602625,0.00004026999],"about_ca_topic_score_codex":0.00059293286,"about_ca_topic_score_gemma":0.0006336551,"teacher_disagreement_score":0.0013214112,"about_ca_system_score_codex":0.0008022747,"about_ca_system_score_gemma":0.00054963655,"threshold_uncertainty_score":0.0058209896},"labels":[],"label_agreement":null},{"id":"W1993257138","doi":"10.1074/jbc.m202562200","title":"The Extracellular Component of a Transport Metabolon","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Component (thermodynamics); Extracellular; Chemistry; Biochemistry; Physics","score_opus":0.02277445772685072,"score_gpt":0.22348204818986633,"score_spread":0.20070759046301562,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993257138","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98402506,0.0023079994,0.008875675,0.0002005103,0.00006663048,0.00005455914,0.0005912108,0.00012673046,0.0037516356],"genre_scores_gemma":[0.9764271,0.0010991269,0.0068328297,0.00011804495,0.00003075641,0.000036660032,0.0018946725,0.000027260732,0.013533559],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990046,0.00000872316,0.0000064854084,0.00003110803,0.000036723985,0.000016522943],"domain_scores_gemma":[0.9999075,0.00000840427,0.000028032195,0.000008190075,0.000021791246,0.00002613708],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000081629085,0.00037427203,0.00019982705,0.00016930756,0.00020108871,0.00045344024,0.0001800354,0.0002935141,0.0025434482],"category_scores_gemma":[0.0001455039,0.0000975495,0.00030680856,0.00013316885,0.00012494373,0.00032313567,0.00034402485,0.00028050848,0.0007202431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000026020984,0.0000036165422,0.0003117836,0.000021162901,0.000003435797,0.00008530325,0.0000075016796,0.000022040253,0.9982687,0.00016935496,0.00002565639,0.0010552378],"study_design_scores_gemma":[0.00001746744,0.00018336026,0.022197107,0.00001870667,0.0000271517,0.0010073319,0.00007803773,0.0016460544,0.96248764,0.00023446766,0.012093316,0.000009323816],"about_ca_topic_score_codex":0.0007556652,"about_ca_topic_score_gemma":0.00069387583,"teacher_disagreement_score":0.0025434482,"about_ca_system_score_codex":0.0004433169,"about_ca_system_score_gemma":0.00036146407,"threshold_uncertainty_score":0.008508682},"labels":[],"label_agreement":null},{"id":"W1994225358","doi":"10.1016/j.bbrc.2012.02.038","title":"Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: Implications for biological assembly and inhibitor development","year":2012,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Gene isoform; Carbonic anhydrase; Isozyme; Bicarbonate; Chemistry; Biochemistry; Active site; Ligand (biochemistry); Enzyme; Crystal structure; Stereochemistry; Biophysics; Biology; Crystallography; Receptor; Gene","score_opus":0.0616170590235554,"score_gpt":0.3377837925454248,"score_spread":0.2761667335218694,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994225358","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9776184,0.0029275145,0.008809085,0.0020155543,0.00023426159,0.000035924593,0.0009781811,0.00021729677,0.0071638385],"genre_scores_gemma":[0.9760996,0.0026079447,0.010724144,0.00033735106,0.000048934042,0.00003336875,0.0032500178,0.000044376342,0.006854137],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999616,0.000004488997,0.0000022845659,0.00000718094,0.000017633862,0.000006806419],"domain_scores_gemma":[0.99990714,0.000018661123,0.000021019297,0.000004806098,0.000021067523,0.000027258304],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285079,0.00019507225,0.00024210768,0.00010229361,0.00029164326,0.00056582876,0.00041258862,0.0003681777,0.0007762412],"category_scores_gemma":[0.00030155358,0.00013605347,0.00012269213,0.00018022311,0.00024365877,0.00022542107,0.00014771207,0.0010451702,0.00019851554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011100478,0.00034499625,0.006951247,0.00034981407,0.000075875214,0.0015272594,0.0005727998,0.010299665,0.91660225,0.024973024,0.014226483,0.022966614],"study_design_scores_gemma":[0.001273881,0.000757788,0.042084835,0.00013431332,0.00018315262,0.0036674317,0.0011621726,0.17940785,0.63668126,0.010597432,0.123938166,0.0001117065],"about_ca_topic_score_codex":0.004161491,"about_ca_topic_score_gemma":0.0053318893,"teacher_disagreement_score":0.004161491,"about_ca_system_score_codex":0.00077531714,"about_ca_system_score_gemma":0.0008451287,"threshold_uncertainty_score":0.008274496},"labels":[],"label_agreement":null},{"id":"W1998512180","doi":"10.1039/c4ra16124f","title":"Metal complexes of tosyl sulfonamides: design, X-ray structure, biological activities and molecular docking studies","year":2015,"lang":"en","type":"article","venue":"RSC Advances","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Tosyl; Docking (animal); Chemistry; Active site; Metal; X-ray; Crystallography; Stereochemistry; Enzyme; Organic chemistry; Physics","score_opus":0.05123040497142899,"score_gpt":0.3065618318311538,"score_spread":0.2553314268597248,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1998512180","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9748157,0.00431148,0.010376755,0.00040865084,0.000092966286,0.00026153828,0.0010167381,0.00032425963,0.00839187],"genre_scores_gemma":[0.9794368,0.0031562494,0.0084747495,0.0000790314,0.000011056271,0.000093079754,0.0012074179,0.000028186314,0.0075134304],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999026,0.00001992909,0.000008320382,0.000016735883,0.00003132575,0.000020982992],"domain_scores_gemma":[0.9999454,0.0000074804884,0.000013532387,0.0000051248603,0.000011120986,0.000017332914],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002163317,0.00042391443,0.0003805366,0.00020246005,0.00018866158,0.00024094821,0.00073799136,0.00024690636,0.0019364642],"category_scores_gemma":[0.00021360203,0.00015056627,0.00021749383,0.0002958499,0.00018453225,0.00013919525,0.00021177568,0.00030993842,0.00044243413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016631166,0.0002785646,0.0008497273,0.00072179514,0.000102491,0.0002978288,0.0001573053,0.012226689,0.95371205,0.0045494605,0.0034053058,0.02203572],"study_design_scores_gemma":[0.00054840615,0.002656882,0.001250016,0.000050139737,0.00010876471,0.0006031341,0.00011726447,0.013689872,0.947164,0.00041872967,0.03334225,0.000050563405],"about_ca_topic_score_codex":0.0031870613,"about_ca_topic_score_gemma":0.0042740586,"teacher_disagreement_score":0.0031870613,"about_ca_system_score_codex":0.0007188048,"about_ca_system_score_gemma":0.000482725,"threshold_uncertainty_score":0.006478131},"labels":[],"label_agreement":null},{"id":"W1999666431","doi":"10.1016/j.cbd.2007.05.001","title":"Evidence for a carbonic anhydrase-related protein in the brain of rainbow trout (Oncorhynchus mykiss)","year":2007,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part D Genomics and Proteomics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Rainbow trout; Carbonic anhydrase; Fishery; Zoology; Rainbow; Fish <Actinopterygii>; Biology; Biochemistry; Enzyme","score_opus":0.043300952464763086,"score_gpt":0.30354732958263003,"score_spread":0.26024637711786697,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999666431","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9970393,0.0007647273,0.0006949763,0.00013653432,0.000018193938,0.000008195754,0.00039115347,0.000024767147,0.00092224503],"genre_scores_gemma":[0.99246913,0.00061240006,0.0016310582,0.00016400352,0.000021580763,0.000037175017,0.0014982804,0.000020365605,0.0035460135],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995434,0.0000019842928,0.0000026745258,0.000016967271,0.0000117074,0.000012359514],"domain_scores_gemma":[0.99979705,0.00001932941,0.000054652006,0.000012072043,0.000053687025,0.0000632291],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000085696935,0.000211444,0.0001789017,0.0004730882,0.00046064216,0.00026835618,0.00025524918,0.00030200297,0.00097090565],"category_scores_gemma":[0.00013639366,0.00020795208,0.00021199489,0.00017283158,0.0005689646,0.00031292596,0.00032476356,0.00051165913,0.00025634593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014785457,0.000013688919,0.0025579415,0.000040404695,0.0000146209995,0.0001228606,0.000040877967,0.000015290736,0.99623555,0.00014702763,0.00006164683,0.0006022949],"study_design_scores_gemma":[0.00007268993,0.00055552006,0.7399297,0.000024400377,0.00012362262,0.0022833934,0.00038438034,0.0006870131,0.25243795,0.00056211825,0.0029138138,0.000025377922],"about_ca_topic_score_codex":0.0067339903,"about_ca_topic_score_gemma":0.011682953,"teacher_disagreement_score":0.0067339903,"about_ca_system_score_codex":0.00042299248,"about_ca_system_score_gemma":0.00051018596,"threshold_uncertainty_score":0.013389587},"labels":[],"label_agreement":null},{"id":"W2002950258","doi":"10.1371/journal.ppat.1002485","title":"The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Biotechnology and Biological Sciences Research Council; Howard Hughes Medical Institute","keywords":"Adenylyl cyclase; Transcription factor; Biology; Regulator; Cell biology; Candida albicans; Saccharomyces cerevisiae; Yeast; cAMP-dependent pathway; Response regulator; Signal transduction; Transcriptional regulation; Biochemistry; Genetics; Gene; Mutant","score_opus":0.024179918868212212,"score_gpt":0.22340649651902245,"score_spread":0.19922657765081023,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2002950258","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.941139,0.015698142,0.03193986,0.00069529464,0.00015307107,0.000069592854,0.0052776695,0.0015982882,0.0034291167],"genre_scores_gemma":[0.97560215,0.00345955,0.012318512,0.0001210669,0.00003133062,0.000054044795,0.0042762966,0.00017308624,0.003963911],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998759,0.000008662661,0.0000075615744,0.00005441458,0.000038360107,0.000015135927],"domain_scores_gemma":[0.9998646,0.000020993582,0.00003340042,0.000017508439,0.000024885554,0.000038593374],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108552806,0.00063932664,0.0004214879,0.0002800187,0.00029117538,0.0005000786,0.0003376609,0.00033707955,0.00093258],"category_scores_gemma":[0.00017020218,0.00020494786,0.00028916777,0.0002678521,0.0002700069,0.000238698,0.00034550362,0.0005719698,0.0009630458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009063249,0.000005113067,0.00017473417,0.00004517137,0.000002844138,0.000063874,0.0000086219625,0.00008822282,0.9973979,0.00011404519,0.00007868807,0.0019301925],"study_design_scores_gemma":[0.000012785406,0.000047063397,0.008451981,0.000009178095,0.000015329779,0.0005696847,0.000023469562,0.0019489431,0.9816343,0.00022324413,0.007053511,0.0000104553965],"about_ca_topic_score_codex":0.00075827976,"about_ca_topic_score_gemma":0.0007417384,"teacher_disagreement_score":0.00093258,"about_ca_system_score_codex":0.0006780713,"about_ca_system_score_gemma":0.0002517651,"threshold_uncertainty_score":0.004919827},"labels":[],"label_agreement":null},{"id":"W2004794745","doi":"10.1074/jbc.m302013200","title":"Assessing the Reversibility of the Anaplerotic Reactions of the Propionyl-CoA Pathway in Heart and Liver","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Chemistry; Biochemistry","score_opus":0.028443379091021834,"score_gpt":0.2616385568313302,"score_spread":0.23319517774030835,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004794745","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99154574,0.0022913164,0.0037481703,0.000058237056,0.000029356916,0.000037579193,0.00042195557,0.000056183206,0.0018113882],"genre_scores_gemma":[0.99101895,0.0013016432,0.0041583143,0.0000512907,0.000019585013,0.00006257231,0.00075579726,0.000051444076,0.002580431],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998286,0.000030179463,0.0000153042,0.00004858232,0.000033259523,0.000044148732],"domain_scores_gemma":[0.9995859,0.000115551375,0.000090839276,0.000050127717,0.00007222289,0.00008536507],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038005458,0.00040222073,0.000272885,0.00026186206,0.0001741467,0.0004431074,0.00030319794,0.00039189137,0.0017486712],"category_scores_gemma":[0.00043260635,0.00021521603,0.0002398382,0.00021581892,0.0003758126,0.0004768646,0.0002063056,0.00071147847,0.00033208402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00033818622,0.000010895806,0.00062379293,0.000022792688,0.000007217385,0.000020382871,0.000023178993,0.000040202012,0.99801266,0.000046986483,0.000007087622,0.00084648014],"study_design_scores_gemma":[0.000015161256,0.0003733146,0.0099692745,0.0000034465552,0.000020670697,0.00005460034,0.000036751375,0.000544047,0.98846966,0.000044168653,0.0004610453,0.000007944464],"about_ca_topic_score_codex":0.0010356886,"about_ca_topic_score_gemma":0.0010090908,"teacher_disagreement_score":0.0017486712,"about_ca_system_score_codex":0.0002823198,"about_ca_system_score_gemma":0.00035895538,"threshold_uncertainty_score":0.005849898},"labels":[],"label_agreement":null},{"id":"W2007978747","doi":"10.1139/b05-057","title":"Cyanobacterial carbonic anhydrases","year":2005,"lang":"en","type":"article","venue":"Canadian Journal of Botany","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Cyanobacteria; Carbonic anhydrase; Synechococcus; Prochlorococcus; Biochemistry; Enzyme; Biology; Synechocystis; Chemistry; Botany; Bacteria; Genetics","score_opus":0.0056986271458474,"score_gpt":0.19879303529627532,"score_spread":0.19309440815042792,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2007978747","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91354066,0.031009374,0.020515542,0.0008917526,0.00011033008,0.00014125113,0.0034866845,0.00068726786,0.029617153],"genre_scores_gemma":[0.97208554,0.007769536,0.007725033,0.00028058188,0.000031313844,0.000029327699,0.0018387126,0.000030600862,0.01020942],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997665,0.000012044363,0.000012695677,0.00005188797,0.00011979646,0.000036980422],"domain_scores_gemma":[0.99985886,0.000012091445,0.00002593771,0.000010678236,0.00005481329,0.000037536916],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010839373,0.00028334392,0.00019369498,0.00024933615,0.00039361985,0.0003895734,0.00014401811,0.00020453439,0.00071362295],"category_scores_gemma":[0.0002200677,0.0000932012,0.000093700946,0.00035407126,0.00023688446,0.00021390898,0.0002601408,0.00021053146,0.00061225164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000035568562,0.0000056866024,0.0016052991,0.000101335354,0.0000034174016,0.00007725866,0.000033766584,0.000051276158,0.99034977,0.0005089372,0.00028931256,0.006938412],"study_design_scores_gemma":[0.000015385875,0.00009628405,0.070123345,0.000035237197,0.000018899736,0.0016364949,0.00014625359,0.0010620755,0.8630075,0.0007969936,0.063044876,0.000016559266],"about_ca_topic_score_codex":0.005110625,"about_ca_topic_score_gemma":0.008572219,"teacher_disagreement_score":0.005110625,"about_ca_system_score_codex":0.00082249293,"about_ca_system_score_gemma":0.0005528959,"threshold_uncertainty_score":0.0101617575},"labels":[],"label_agreement":null},{"id":"W2009100934","doi":"10.1021/ic026239t","title":"Synthesis and Characterization of N<sub>2</sub>S<sub>3</sub>X−Fe Models of Iron-Containing Nitrile Hydratase","year":2003,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Steacie Institute for Molecular Sciences","funders":"","keywords":"Chemistry; Nitrile hydratase; Triclinic crystal system; Nitrile; Crystallography; Ligand (biochemistry); Cyanide; Density functional theory; Stereochemistry; Derivative (finance); Crystal structure; Inorganic chemistry; Computational chemistry; Organic chemistry","score_opus":0.006635142568597104,"score_gpt":0.18592655648850875,"score_spread":0.17929141391991166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2009100934","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99566585,0.00026308483,0.0027252443,0.000020177868,0.0000069755265,0.00003141288,0.000158483,0.000046384608,0.0010823129],"genre_scores_gemma":[0.99202216,0.00024725767,0.005000467,0.000018508566,0.0000036627482,0.000034689267,0.00049363216,0.000027222362,0.002152458],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999411,0.00001246842,0.0000039215593,0.000011108102,0.000022998289,0.000008368722],"domain_scores_gemma":[0.9999461,0.0000063814887,0.000013768263,0.0000062059667,0.000011952313,0.000015560698],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103025755,0.00020265646,0.0001986786,0.0000674648,0.00009702913,0.00016982884,0.00023874556,0.00021728633,0.0005611978],"category_scores_gemma":[0.0001167156,0.00008730763,0.000081540005,0.00007805846,0.00010492849,0.00011705913,0.00011767287,0.00016744634,0.00017703896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007740368,0.00001819802,0.00016635424,0.000031778218,0.0000034292473,0.00003185523,0.000015178776,0.00030852735,0.9981975,0.000113538765,0.000042026215,0.0009942512],"study_design_scores_gemma":[0.000016645901,0.0002850457,0.0011335335,0.0000029287621,0.000006049929,0.000100961675,0.00001301664,0.0019917341,0.99437296,0.000029226589,0.0020443904,0.0000035632854],"about_ca_topic_score_codex":0.0009365567,"about_ca_topic_score_gemma":0.0017124433,"teacher_disagreement_score":0.0009365567,"about_ca_system_score_codex":0.00026569475,"about_ca_system_score_gemma":0.00010017781,"threshold_uncertainty_score":0.0019277334},"labels":[],"label_agreement":null},{"id":"W2011308240","doi":"10.1139/o04-033","title":"Conformational change and inactivation of arginine kinase from shrimp <i>Feneropenaeus chinensis</i> in oxidized dithiothreitol solutions","year":2004,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Dithiothreitol; Arginine kinase; Chemistry; Size-exclusion chromatography; Fluorescence; Gel electrophoresis; Conformational change; Sodium dodecyl sulfate; Biochemistry; Polyacrylamide gel electrophoresis; Arginine; Biophysics; Chromatography; Enzyme; Biology; Amino acid","score_opus":0.015448696219455667,"score_gpt":0.22025227401959094,"score_spread":0.20480357780013528,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2011308240","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99900156,0.00026085135,0.0003594274,0.000019732417,0.000004151647,0.00000413511,0.00006420469,0.000007340875,0.00027871004],"genre_scores_gemma":[0.9983681,0.00023881109,0.0005669646,0.000017270717,0.0000032843604,0.000008874871,0.0002464738,0.0000048919887,0.00054528296],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999336,0.00000948713,0.0000074773475,0.000017865352,0.000017958464,0.000013558281],"domain_scores_gemma":[0.9999256,0.000013533526,0.000020714046,0.000011385008,0.000014056919,0.000014665222],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012579274,0.00030028407,0.00016599953,0.00009559186,0.000107072716,0.00017569447,0.0002004243,0.0001690327,0.0005201272],"category_scores_gemma":[0.00018166857,0.00010440141,0.00019453044,0.00011058239,0.00020406961,0.00018429803,0.00010721055,0.0003029035,0.00011309862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005799977,0.0000042029,0.0002039852,0.000016368187,0.000003146758,0.00003194562,0.000019328028,0.00003110339,0.99933285,0.000018875975,0.0000037399586,0.00027642527],"study_design_scores_gemma":[0.000009104607,0.00011674664,0.008672818,0.0000030011265,0.000010435865,0.00015117535,0.000028182345,0.00047556986,0.990085,0.000036088935,0.00040561912,0.000006351901],"about_ca_topic_score_codex":0.0012557314,"about_ca_topic_score_gemma":0.001115782,"teacher_disagreement_score":0.0012557314,"about_ca_system_score_codex":0.0002222737,"about_ca_system_score_gemma":0.00013997855,"threshold_uncertainty_score":0.0024968982},"labels":[],"label_agreement":null},{"id":"W2012370038","doi":"10.1016/j.bmcl.2011.07.090","title":"Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Carbonic anhydrase; Structural isomer; Stereochemistry; Gene isoform; Cytosol; Enzyme; Enzyme inhibitor; Transmembrane protein; Chemical synthesis; Biochemistry; In vitro; Receptor","score_opus":0.008149221378740686,"score_gpt":0.18893032678089355,"score_spread":0.18078110540215286,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012370038","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98270226,0.0025109402,0.005382956,0.00019155019,0.000096089025,0.000052431267,0.0002932721,0.00024619585,0.008524367],"genre_scores_gemma":[0.99024487,0.0018777623,0.0013781352,0.00008691446,0.000021489192,0.000029055696,0.00033132007,0.000036600606,0.0059939045],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986815,0.00002024804,0.00000771439,0.000019779089,0.00003391682,0.000050045943],"domain_scores_gemma":[0.999928,0.000017288567,0.000021324275,0.000009413679,0.000009170844,0.000014813836],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018083797,0.0004168329,0.00022191752,0.00012269856,0.00011125667,0.0001777716,0.0002832583,0.00020545386,0.0016787866],"category_scores_gemma":[0.00015155668,0.00013706536,0.0001884322,0.00013554482,0.00024423163,0.000125409,0.0001157988,0.0004543304,0.0005693693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001302019,0.00001858828,0.00008146009,0.000023389086,0.0000063498956,0.000048063655,0.000013332648,0.00009768771,0.99763525,0.00024271506,0.00011869691,0.001584249],"study_design_scores_gemma":[0.00002493222,0.00034299435,0.0009557242,0.0000024215394,0.000008679859,0.00020640632,0.000012342828,0.00024522553,0.99631566,0.000034045046,0.0018482251,0.0000034141042],"about_ca_topic_score_codex":0.0012471017,"about_ca_topic_score_gemma":0.0034007954,"teacher_disagreement_score":0.0016787866,"about_ca_system_score_codex":0.00031499215,"about_ca_system_score_gemma":0.00035691433,"threshold_uncertainty_score":0.0056161284},"labels":[],"label_agreement":null},{"id":"W2012762703","doi":"10.1165/rcmb.2014-0054oc","title":"Carbonic Anhydrase II Mediates Malignant Behavior of Pulmonary Neuroendocrine Tumors","year":2014,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Carbonic anhydrase; Neuroendocrine tumors; Cancer research; Medicine; Chemistry; Biology; Pathology; Internal medicine; Enzyme; Biochemistry","score_opus":0.004647278743161699,"score_gpt":0.22850431730933995,"score_spread":0.22385703856617825,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012762703","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99525046,0.0020719625,0.0013992571,0.000056704295,0.000011251155,0.000018705907,0.00011643025,0.00004536828,0.0010297751],"genre_scores_gemma":[0.99857235,0.00055085577,0.0002300323,0.000011963265,0.000005438094,0.000008259209,0.000099388824,0.000003537522,0.0005182325],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993324,0.000009484775,0.00000530118,0.000015789072,0.00002132634,0.0000149199805],"domain_scores_gemma":[0.9999255,0.000013058926,0.000024129014,0.0000069635516,0.000009821755,0.000020653053],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000071988245,0.00020433089,0.00014873322,0.00011088989,0.00009270314,0.00021453419,0.00008791459,0.00015142105,0.00044286478],"category_scores_gemma":[0.00009506907,0.00006984805,0.00011044486,0.00007753197,0.00015784526,0.0001184579,0.00010240888,0.00026721085,0.00012838481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003528552,0.0000058741944,0.0009066148,0.000017015012,0.0000030895549,0.00009111654,0.000010269878,0.000020159208,0.9983328,0.000033613054,0.000014510056,0.0005297497],"study_design_scores_gemma":[0.000013798591,0.0003452169,0.06334639,0.0000056385397,0.000027181288,0.0012900268,0.00008564035,0.0010721877,0.93143666,0.00010405919,0.0022676697,0.000005494021],"about_ca_topic_score_codex":0.0005638809,"about_ca_topic_score_gemma":0.0007880409,"teacher_disagreement_score":0.0005638809,"about_ca_system_score_codex":0.00023138177,"about_ca_system_score_gemma":0.00011521856,"threshold_uncertainty_score":0.0016788244},"labels":[],"label_agreement":null},{"id":"W2012912649","doi":"10.1152/ajpregu.90685.2008","title":"Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish,<i>Danio rerio</i>","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Genomics; University of Ottawa","funders":"","keywords":"Extracellular; Acidosis; Hypoxia (environmental); Intracellular pH; Zebrafish; Intracellular; Biology; Carbonic anhydrase; Endocrinology; Internal medicine; Biochemistry; Chemistry; Cell biology; Enzyme; Oxygen; Medicine","score_opus":0.01954193936163532,"score_gpt":0.2549816698502465,"score_spread":0.2354397304886112,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012912649","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99513274,0.0009896746,0.0012537795,0.00020911665,0.000036490088,0.000027746355,0.0004737645,0.00007014049,0.0018063716],"genre_scores_gemma":[0.9885167,0.0007576902,0.0018798558,0.00017577429,0.000011734754,0.000058883194,0.0006177866,0.000050087456,0.007931451],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998994,0.0000058556643,0.000011630551,0.0000306114,0.00002540586,0.0000270256],"domain_scores_gemma":[0.99983275,0.000014521523,0.00006798747,0.000012219046,0.000022752849,0.000049815702],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012432845,0.0003125598,0.0003239917,0.00012531756,0.00017946858,0.00022989853,0.00029500943,0.0003369896,0.0011642295],"category_scores_gemma":[0.0001481105,0.00022222451,0.00029624027,0.00007209412,0.000370298,0.00024468265,0.00023155876,0.0004725343,0.00022992287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007405442,0.000002504519,0.00017459402,0.000024990424,0.000004033523,0.00003188031,0.000014370788,0.000018807177,0.99929595,0.000037406036,0.000033020595,0.0002883792],"study_design_scores_gemma":[0.00004800565,0.00059005944,0.026163213,0.000023588245,0.000072135226,0.00032653403,0.00019666443,0.0010733153,0.9666009,0.00007688449,0.004813221,0.00001540448],"about_ca_topic_score_codex":0.007356202,"about_ca_topic_score_gemma":0.013632635,"teacher_disagreement_score":0.007356202,"about_ca_system_score_codex":0.0007423989,"about_ca_system_score_gemma":0.00049153186,"threshold_uncertainty_score":0.014626741},"labels":[],"label_agreement":null},{"id":"W2014598933","doi":"10.1016/j.cbpa.2009.10.043","title":"Gas transfer in dogfish: A unique model of CO2 excretion","year":2009,"lang":"en","type":"review","venue":"Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Gill; Excretion; Carbonic anhydrase; Cytosol; Dehydration; Biochemistry; Biology; Chemistry; Osmoregulation; Euryhaline; Enzyme; Fish <Actinopterygii>; Ecology; Fishery; Salinity","score_opus":0.042970599416163685,"score_gpt":0.3190852101610898,"score_spread":0.27611461074492616,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2014598933","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0014307796,0.9921645,0.0032297235,0.00061496615,0.00041248207,0.000008293326,0.000032331314,0.000028594446,0.002078353],"genre_scores_gemma":[0.008237571,0.9867446,0.001963376,0.00025588684,0.00024365928,0.00001706115,0.000055943376,0.000006338535,0.0024756],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998884,0.000009243058,0.000012472008,0.000042516815,0.00003660145,0.000010645475],"domain_scores_gemma":[0.9998852,0.00003614401,0.000017330398,0.00000872837,0.000037544494,0.0000150548585],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00053415133,0.00092055823,0.0014417177,0.0010197335,0.00025505773,0.0010702081,0.001343156,0.0014453854,0.0010563396],"category_scores_gemma":[0.00024443338,0.0004090524,0.00035754708,0.0010132882,0.0017104335,0.0017381426,0.0007843269,0.001529846,0.0009470553],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021875977,0.00006256619,0.00087849237,0.013666536,0.00017319158,0.0010949647,0.00012141898,0.0022601294,0.055304144,0.029285384,0.013252094,0.8836824],"study_design_scores_gemma":[0.000035280817,0.00018076315,0.0022560018,0.00075151084,0.00016218313,0.0025749265,0.00014149668,0.0010933392,0.013539167,0.011792015,0.96741164,0.00006165072],"about_ca_topic_score_codex":0.0022302298,"about_ca_topic_score_gemma":0.0023756383,"teacher_disagreement_score":0.0022302298,"about_ca_system_score_codex":0.0012634763,"about_ca_system_score_gemma":0.0013366089,"threshold_uncertainty_score":0.009167135},"labels":[],"label_agreement":null},{"id":"W2017394485","doi":"10.1042/bj20070384","title":"A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase","year":2007,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; U.S. Public Health Service","keywords":"Transferrin; Carbonic anhydrase; Biochemistry; Homologous chromosome; Carbonic anhydrase II; Homeostasis; Iron homeostasis; Chemistry; Protein superfamily; Biology; Enzyme; Metabolism; Cell biology; Gene","score_opus":0.004466066691731657,"score_gpt":0.21697041500032463,"score_spread":0.21250434830859297,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2017394485","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9842295,0.0018849875,0.008400407,0.0002154888,0.00006877079,0.00007908022,0.0016522864,0.00022859566,0.0032409227],"genre_scores_gemma":[0.96928567,0.00089065096,0.012121339,0.00014514526,0.000030703683,0.00007733583,0.008302552,0.00006872516,0.009077923],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999175,0.000008934888,0.0000066457933,0.000022754517,0.000028148634,0.000016005955],"domain_scores_gemma":[0.9999105,0.000014093083,0.000024840458,0.000009221585,0.000011703426,0.00002972855],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008305808,0.000332499,0.00018416208,0.00020622005,0.00012912083,0.00022106811,0.00027997623,0.00038059123,0.0014731992],"category_scores_gemma":[0.00010667861,0.000105392886,0.0003189882,0.0002062051,0.0002533614,0.000111901536,0.00015231424,0.00037386565,0.00081121054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006702409,0.000012227536,0.00016280464,0.000028734423,0.000003030175,0.000079852485,0.0000074257737,0.00003690467,0.99810874,0.00014286763,0.000057530782,0.0012929819],"study_design_scores_gemma":[0.000064481355,0.0008095317,0.013457705,0.000023007942,0.000037483987,0.0027424605,0.00003714762,0.0013588191,0.9504316,0.00014407694,0.03087921,0.000014487255],"about_ca_topic_score_codex":0.0005933054,"about_ca_topic_score_gemma":0.00043989575,"teacher_disagreement_score":0.0014731992,"about_ca_system_score_codex":0.00040994206,"about_ca_system_score_gemma":0.00028426712,"threshold_uncertainty_score":0.004928291},"labels":[],"label_agreement":null},{"id":"W2021669959","doi":"10.3109/14756366.2011.596836","title":"Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds","year":2011,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Carbonic anhydrase; Chemistry; Isozyme; Molecule; Enzyme; Bisphenol A; Bisphenol; Carbonic anhydrase II; Stereochemistry; Biochemistry; Thiadiazoles; Bromophenol blue; Medicinal chemistry; Organic chemistry; Chromatography","score_opus":0.014684854142294349,"score_gpt":0.23191467637020602,"score_spread":0.21722982222791168,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2021669959","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9796062,0.011878537,0.005499661,0.00021053212,0.000046250632,0.00008056874,0.00024091745,0.0000501007,0.0023871264],"genre_scores_gemma":[0.9798105,0.009438006,0.007600873,0.00008653444,0.000014338599,0.00006497344,0.0004368549,0.000008731363,0.0025392214],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999361,0.000017145792,0.0000047795484,0.000009435111,0.000020932628,0.000011569757],"domain_scores_gemma":[0.999962,0.00000800049,0.000013105965,0.000002968983,0.000006507977,0.0000073342876],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107357555,0.00030329998,0.00019399919,0.0001245336,0.000087757864,0.00010671138,0.00017956631,0.00015621693,0.0005094791],"category_scores_gemma":[0.00011725406,0.00008406175,0.000223469,0.00015675799,0.00009630469,0.00010686749,0.00010402102,0.00033858055,0.00013943875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020535645,0.00009001886,0.0003412043,0.00016032482,0.000029165623,0.00008982856,0.000016696673,0.0010832535,0.99100786,0.00012397867,0.00010942466,0.006742918],"study_design_scores_gemma":[0.00004371697,0.0010303542,0.0027017302,0.00001009132,0.000029593557,0.00023973195,0.000011580673,0.0015716158,0.989856,0.00003355709,0.0044653136,0.0000067032042],"about_ca_topic_score_codex":0.000728487,"about_ca_topic_score_gemma":0.0020188382,"teacher_disagreement_score":0.000728487,"about_ca_system_score_codex":0.00014317835,"about_ca_system_score_gemma":0.00017593386,"threshold_uncertainty_score":0.0017043352},"labels":[],"label_agreement":null},{"id":"W2022203610","doi":"10.1021/jm031079w","title":"Carbonic Anhydrase Inhibitors. Design of Selective, Membrane-Impermeant Inhibitors Targeting the Human Tumor-Associated Isozyme IX","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"Isozyme; Chemistry; Carbonic anhydrase; Pyridinium; Cytosol; Aryl; Enzyme; Stereochemistry; Membrane; Alkyl; Carbonic anhydrase II; Enzyme inhibitor; Alkylation; Biochemistry; Medicinal chemistry; Organic chemistry; Catalysis","score_opus":0.008348009060418913,"score_gpt":0.23283660010656537,"score_spread":0.22448859104614646,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022203610","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96739364,0.014990244,0.012122498,0.00021430655,0.000093885574,0.0005088526,0.000671232,0.00022509973,0.0037802418],"genre_scores_gemma":[0.9743007,0.008103563,0.011330721,0.00012249367,0.00003759535,0.00025306933,0.000850741,0.000021526263,0.0049794633],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999336,0.000008977808,0.0000059367585,0.000017149148,0.000018814228,0.000015498108],"domain_scores_gemma":[0.9999474,0.000005187081,0.000019520194,0.0000028066338,0.000010585975,0.000014411707],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013710327,0.000528558,0.0003060703,0.00013343044,0.00006553647,0.00018547777,0.00029409394,0.00028256132,0.0005468266],"category_scores_gemma":[0.000092216455,0.0001478176,0.00019173107,0.00011413392,0.00013541589,0.00018434426,0.00012802344,0.00037090637,0.00025038148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001679983,0.000047416383,0.00013916794,0.00008173198,0.000012275034,0.000048423994,0.00001186406,0.0003295923,0.9939704,0.00014433508,0.000086667096,0.0049600783],"study_design_scores_gemma":[0.00016779837,0.0016252174,0.0020075357,0.000008117817,0.000046743153,0.0004179649,0.000009865961,0.0017260803,0.98588294,0.000044792105,0.008054564,0.000008217401],"about_ca_topic_score_codex":0.0004758768,"about_ca_topic_score_gemma":0.0013802652,"teacher_disagreement_score":0.0005468266,"about_ca_system_score_codex":0.00042867442,"about_ca_system_score_gemma":0.00019373043,"threshold_uncertainty_score":0.0031102896},"labels":[],"label_agreement":null},{"id":"W2024699500","doi":"10.1002/ppsc.201400025","title":"Hierarchical Stable Enzyme Microenvironments for High‐Temperature Stability in Amine Solvents","year":2014,"lang":"en","type":"article","venue":"Particle & Particle Systems Characterization","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal General Hospital; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Amine gas treating; Chemical engineering; Enzyme; Chemistry; Stability (learning theory); Materials science; Biophysics; Organic chemistry; Biology; Computer science","score_opus":0.010127241377519325,"score_gpt":0.21668878854018098,"score_spread":0.20656154716266165,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024699500","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98417586,0.0010998875,0.013400633,0.0000660513,0.000025326175,0.000038962913,0.00012210687,0.00021674705,0.0008544932],"genre_scores_gemma":[0.9914739,0.00027468934,0.0074235154,0.000019612795,0.0000067679175,0.000022524899,0.00008843118,0.000016050068,0.0006745754],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998692,0.000012185523,0.000012301901,0.000037484006,0.000035738198,0.00003308621],"domain_scores_gemma":[0.99983716,0.000038089707,0.000046239464,0.000020059042,0.00002884351,0.000029594326],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014580334,0.00023184266,0.00020346654,0.00016062146,0.00012171202,0.00031256516,0.00021212087,0.00033006963,0.0004412523],"category_scores_gemma":[0.0002253059,0.00019456068,0.00022007756,0.00010464581,0.00020286371,0.00019813432,0.00017797526,0.00036820228,0.00026959632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000008197671,0.000007274158,0.000036001988,0.0000119387405,0.0000016391059,0.000013328017,0.000008640946,0.00008030207,0.9993766,0.000041871186,0.00001014264,0.00040397674],"study_design_scores_gemma":[0.0000036863041,0.000053104683,0.00081642956,0.0000014005236,0.000004256122,0.00004094023,0.0000051048673,0.0009933678,0.99753124,0.000014983764,0.0005322421,0.0000032580297],"about_ca_topic_score_codex":0.0006539798,"about_ca_topic_score_gemma":0.0017018829,"teacher_disagreement_score":0.0006539798,"about_ca_system_score_codex":0.0003504869,"about_ca_system_score_gemma":0.00014895476,"threshold_uncertainty_score":0.0025429726},"labels":[],"label_agreement":null},{"id":"W2027133190","doi":"10.1016/j.cbpa.2010.06.161","title":"Perspectives on carbonic anhydrase","year":2010,"lang":"en","type":"review","venue":"Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Carbonic anhydrase; Function (biology); Biology; Gene isoform; Cancer; Biochemistry; Chemistry; Medicine; Enzyme; Cell biology; Genetics; Gene","score_opus":0.028186208057992577,"score_gpt":0.3260417752594278,"score_spread":0.2978555672014352,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2027133190","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000072052666,0.9971644,0.00021137526,0.00074064627,0.000735112,0.0000016384532,0.00000778266,0.0000056935514,0.0010611919],"genre_scores_gemma":[0.0006569061,0.9961235,0.0002744264,0.00063539535,0.0010775402,0.0000060148845,0.000021370626,0.0000019129552,0.0012028433],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99978834,0.000034471544,0.000021795091,0.000049545142,0.0000792746,0.000026639298],"domain_scores_gemma":[0.9997141,0.00011570327,0.000026086405,0.000013817783,0.00008694864,0.00004334026],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010767059,0.001367925,0.0015531265,0.0016866133,0.000408196,0.0013852682,0.001438434,0.0018946336,0.0034422087],"category_scores_gemma":[0.00068386825,0.00035635912,0.00041189542,0.0022363735,0.0013749112,0.0028061566,0.0012011766,0.0030351097,0.002027918],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020170433,0.00009819097,0.00019205362,0.012420845,0.00010629314,0.00043885727,0.00010123719,0.0007415867,0.009585667,0.0310808,0.09000917,0.85502356],"study_design_scores_gemma":[0.000018023418,0.00003073205,0.000261439,0.0007417038,0.00003338412,0.00039135208,0.00003451866,0.00006590367,0.0005034311,0.005182171,0.9927263,0.000011073313],"about_ca_topic_score_codex":0.0013473572,"about_ca_topic_score_gemma":0.0025888595,"teacher_disagreement_score":0.0034422087,"about_ca_system_score_codex":0.0013158827,"about_ca_system_score_gemma":0.0017155985,"threshold_uncertainty_score":0.011515319},"labels":[],"label_agreement":null},{"id":"W2027356017","doi":"10.1021/jm200983e","title":"Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Carbonic anhydrase; Chemistry; Coumarin; Enzyme; Glycosyl; Gene isoform; Biochemistry; Acetazolamide; Carbonic anhydrase II; Cancer research; Internal medicine; Biology","score_opus":0.009047190541452064,"score_gpt":0.19922973671820002,"score_spread":0.19018254617674796,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2027356017","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9941876,0.0020617712,0.0010452339,0.000060339975,0.000018355207,0.00003318922,0.00026703547,0.000071824485,0.00225465],"genre_scores_gemma":[0.9934169,0.0019600762,0.0011205324,0.0000308544,0.000009910571,0.000024584826,0.0005064635,0.00001540013,0.0029153123],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999491,0.000005912566,0.000002709811,0.000007696804,0.000014703575,0.000019918654],"domain_scores_gemma":[0.9999387,0.000012151564,0.000014811127,0.000005933574,0.000009706318,0.000018712042],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000066729626,0.00032790427,0.00024498868,0.00016918815,0.00008355857,0.00011842368,0.00014070279,0.00014661333,0.0010629046],"category_scores_gemma":[0.0000927439,0.00008090126,0.000111826346,0.00015521383,0.00010829598,0.000078132856,0.000053977874,0.0003662474,0.00021487975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017696143,0.000063946914,0.0001404523,0.00003371929,0.0000075246803,0.00003798972,0.00000820461,0.00022939703,0.9959229,0.00007966029,0.00008809656,0.0032111625],"study_design_scores_gemma":[0.000027765751,0.0008954957,0.0015432643,0.0000021801122,0.00001706541,0.00009074248,0.0000059627814,0.00033785214,0.99530244,0.000016853262,0.0017580657,0.0000022475538],"about_ca_topic_score_codex":0.0010563396,"about_ca_topic_score_gemma":0.0031053985,"teacher_disagreement_score":0.0010629046,"about_ca_system_score_codex":0.00021390754,"about_ca_system_score_gemma":0.00019659253,"threshold_uncertainty_score":0.0035557747},"labels":[],"label_agreement":null},{"id":"W2028005732","doi":"10.1007/s00360-002-0253-4","title":"Subcellular distribution and characterization of gill carbonic anhydrase and evidence for a plasma carbonic anhydrase inhibitor in Antarctic fish","year":2002,"lang":"en","type":"article","venue":"Journal of Comparative Physiology B","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"","keywords":"Carbonic anhydrase; Fish <Actinopterygii>; Biochemistry; Chemistry; Enzyme; Biology; Fishery","score_opus":0.034749656521856825,"score_gpt":0.27428345010503113,"score_spread":0.2395337935831743,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2028005732","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9955817,0.0011289559,0.0010656443,0.000056953322,0.000007114438,0.000008187231,0.0003153378,0.000014651673,0.0018213848],"genre_scores_gemma":[0.9924918,0.0011161895,0.0015399838,0.00003966634,0.000014773103,0.000025006633,0.0007614673,0.000019056728,0.0039920057],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9999596,0.0000023357293,0.0000034326872,0.000010993361,0.00000922304,0.000014415194],"domain_scores_gemma":[0.9998486,0.00002101436,0.000034441644,0.000017797785,0.000037006957,0.00004114545],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000085303385,0.0001964919,0.00019421722,0.00042540985,0.00027901083,0.00025531612,0.00019464825,0.00022410783,0.00091250805],"category_scores_gemma":[0.00015249777,0.00025893966,0.00021772162,0.00027493236,0.00033491783,0.00028819044,0.00021640184,0.0002897034,0.0004146607],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024261545,0.0000062588747,0.0038088574,0.000041753316,0.000007482724,0.0000962529,0.0000857966,0.00004099876,0.99419385,0.00016798527,0.000031155163,0.0012770832],"study_design_scores_gemma":[0.00005441906,0.00045885248,0.45753232,0.000017088463,0.00009148762,0.0020847085,0.0004835741,0.0015407326,0.5300532,0.0003202155,0.007332791,0.000030588162],"about_ca_topic_score_codex":0.007787909,"about_ca_topic_score_gemma":0.008386574,"teacher_disagreement_score":0.007787909,"about_ca_system_score_codex":0.0004979489,"about_ca_system_score_gemma":0.00028422487,"threshold_uncertainty_score":0.0154851675},"labels":[],"label_agreement":null},{"id":"W2028512642","doi":"10.1242/jeb.01780","title":"An investigation of the role of carbonic anhydrase in aquatic and aerial gas transfer in the African lungfish<i>Protopterus dolloi</i>","year":2005,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Acetazolamide; Carbonic anhydrase; Chemistry; Hypercapnia; Extracellular; pCO2; Excretion; Alkalosis; Lungfish; Extracellular fluid; Carbonic anhydrase inhibitor; Endocrinology; Internal medicine; Intracellular pH; Biochemistry; Acidosis; Biology; Enzyme; Medicine","score_opus":0.0066061191937051185,"score_gpt":0.24199700099870156,"score_spread":0.23539088180499643,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2028512642","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9980755,0.0005722123,0.00035052517,0.000038015376,0.0000034057546,0.000016620395,0.00012431461,0.0000103983975,0.0008089319],"genre_scores_gemma":[0.9960366,0.0005893438,0.0015724004,0.000059832124,0.0000054797415,0.000042833068,0.00021422315,0.0000060364423,0.0014732507],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9999541,0.0000038171456,0.0000025858462,0.000017467542,0.000010993425,0.000011062998],"domain_scores_gemma":[0.9998901,0.000016837905,0.000035029883,0.000008064459,0.0000138429705,0.000036130954],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007019112,0.00032675275,0.00025428535,0.00017705887,0.00023392562,0.0002079051,0.00027154476,0.00049415766,0.00071034976],"category_scores_gemma":[0.00012547827,0.00017141686,0.0002304942,0.00009918715,0.00035241307,0.0003154339,0.00027313174,0.00036083127,0.00017681542],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014364668,0.0000063948173,0.0016980275,0.000054324384,0.0000052193077,0.00008306603,0.000033489578,0.000032307482,0.9969332,0.000032649335,0.000008695599,0.0009688521],"study_design_scores_gemma":[0.00007693464,0.0033946333,0.3374873,0.000021808459,0.00009469756,0.0019434526,0.0005975227,0.0016626306,0.6500431,0.0001896376,0.0044548055,0.00003358023],"about_ca_topic_score_codex":0.003873808,"about_ca_topic_score_gemma":0.005014981,"teacher_disagreement_score":0.003873808,"about_ca_system_score_codex":0.0004123476,"about_ca_system_score_gemma":0.0002918285,"threshold_uncertainty_score":0.00770247},"labels":[],"label_agreement":null},{"id":"W2029534411","doi":"10.1021/ie060287u","title":"Investigating the Application of Enzyme Carbonic Anhydrase for CO<sub>2</sub> Sequestration Purposes","year":2007,"lang":"en","type":"article","venue":"Industrial & Engineering Chemistry Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":305,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Regina","funders":"University of Regina","keywords":"Carbonic anhydrase; Chemistry; Calcium carbonate; Carbon dioxide; Carbonate; Precipitation; Inorganic chemistry; Calcium; Carbonate minerals; Enzyme; Organic chemistry","score_opus":0.05684689339274789,"score_gpt":0.33141903718458615,"score_spread":0.27457214379183825,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2029534411","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95653725,0.021322666,0.017916754,0.00068439974,0.00012483365,0.000083067345,0.00011417459,0.000078556026,0.0031382747],"genre_scores_gemma":[0.9830973,0.0075110164,0.00779486,0.00006654163,0.00002700739,0.000015339132,0.000092835224,0.000010539576,0.0013846325],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998579,0.000028711167,0.000009225674,0.00003157443,0.000046170313,0.000026461474],"domain_scores_gemma":[0.99987614,0.000046144396,0.000021489795,0.000009842067,0.000030764102,0.000015702282],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027025078,0.00044351368,0.00039492993,0.0001311997,0.00012730279,0.0005453697,0.00029431947,0.00061650487,0.00039009107],"category_scores_gemma":[0.00031576908,0.00013320085,0.00024861973,0.00018672486,0.00028441896,0.0003493958,0.00012993105,0.00034776196,0.00019059914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000045906214,0.000028498405,0.0002668143,0.00009224647,0.00000844572,0.00004884757,0.00000676279,0.0001523487,0.99654764,0.0001007241,0.000021995205,0.0026798928],"study_design_scores_gemma":[0.0000040343225,0.00017167273,0.0008895411,0.0000033398792,0.000015882468,0.0001269714,0.000010129353,0.0010343894,0.9959602,0.000021090797,0.0017602806,0.0000024638118],"about_ca_topic_score_codex":0.0009674707,"about_ca_topic_score_gemma":0.0010379114,"teacher_disagreement_score":0.0009674707,"about_ca_system_score_codex":0.00037845346,"about_ca_system_score_gemma":0.00021987411,"threshold_uncertainty_score":0.0027459264},"labels":[],"label_agreement":null},{"id":"W2030432995","doi":"10.1016/s1095-6433(03)00159-4","title":"Comparative physiology and molecular evolution of carbonic anhydrase in the erythrocytes of early vertebrates","year":2003,"lang":"en","type":"review","venue":"Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; University of California","keywords":"Carbonic anhydrase; Vertebrate; Biology; Phylogenetic tree; Isozyme; Molecular evolution; Evolutionary biology; Phylogenetics; Enzyme; Biochemistry; Zoology; Gene","score_opus":0.02725023529829189,"score_gpt":0.3081960396307683,"score_spread":0.2809458043324764,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030432995","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0010638357,0.9962863,0.00064461795,0.00022980965,0.00017840845,0.00000494529,0.000028876468,0.000010244896,0.0015529804],"genre_scores_gemma":[0.0030718204,0.9942696,0.0006436955,0.00011904614,0.0001893909,0.000004313319,0.000057775396,0.0000020736725,0.0016422658],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99984336,0.000012660935,0.00002108817,0.000050485716,0.00005950583,0.000012862044],"domain_scores_gemma":[0.99971527,0.000076135955,0.000040576884,0.000011082443,0.00012589982,0.00003117603],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005602463,0.00068207504,0.00115599,0.0016189974,0.00026524698,0.0009830601,0.001058445,0.00094962004,0.0019266686],"category_scores_gemma":[0.00044266874,0.00032624102,0.0002329883,0.0026601055,0.00076741196,0.0011592364,0.00054753775,0.0008688217,0.0010949804],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011341054,0.000028792972,0.0006145187,0.0055371025,0.000060374387,0.0003240937,0.00010586238,0.0006916716,0.013159594,0.0042391582,0.008416687,0.96670884],"study_design_scores_gemma":[0.000023247612,0.00008644377,0.0065707536,0.0010693066,0.00013467557,0.0020812354,0.00012328953,0.00021756387,0.003902188,0.0034153245,0.98234475,0.000031188833],"about_ca_topic_score_codex":0.0037992136,"about_ca_topic_score_gemma":0.0049044588,"teacher_disagreement_score":0.0037992136,"about_ca_system_score_codex":0.001185228,"about_ca_system_score_gemma":0.0012549751,"threshold_uncertainty_score":0.00859946},"labels":[],"label_agreement":null},{"id":"W2030491250","doi":"10.1016/j.bmcl.2004.11.057","title":"Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"European Commission","keywords":"Malonate; Isozyme; Oxalate; Chemistry; Carbonic anhydrase; Carbonic Anhydrase I; Malate dehydrogenase; Cytosol; Biochemistry; Formate; Stereochemistry; Enzyme; Inorganic chemistry; Catalysis","score_opus":0.00436310202040927,"score_gpt":0.19758362365616353,"score_spread":0.19322052163575426,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030491250","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82684916,0.1076281,0.018674154,0.0017334226,0.0007243934,0.00029629018,0.0011737283,0.00040550047,0.042515237],"genre_scores_gemma":[0.96476793,0.01851422,0.0026535024,0.00024700124,0.00009766206,0.000068510206,0.00063479075,0.00002695578,0.012989392],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998945,0.000016777327,0.0000056389845,0.000017014218,0.000036113343,0.000030000261],"domain_scores_gemma":[0.99995327,0.000015781561,0.000009055572,0.0000031267416,0.0000066196153,0.000012128887],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015268315,0.00035106274,0.00021925948,0.00013850941,0.00015602075,0.00016649332,0.00029558432,0.00024553377,0.0010144975],"category_scores_gemma":[0.0001829497,0.00012286623,0.00017677312,0.000091382826,0.000121663055,0.00013558878,0.000111072324,0.000374749,0.0003519719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011374558,0.00007863965,0.00029301803,0.00022153712,0.00002972062,0.00017766679,0.000023611497,0.0005088873,0.97857726,0.001985613,0.0010819302,0.0158846],"study_design_scores_gemma":[0.000084687104,0.0003986671,0.0008522692,0.000008624601,0.000026136599,0.00025172278,0.0000047558447,0.00078189594,0.98626477,0.0001594714,0.011161426,0.000005694237],"about_ca_topic_score_codex":0.0013006495,"about_ca_topic_score_gemma":0.0024631545,"teacher_disagreement_score":0.0013006495,"about_ca_system_score_codex":0.00031790166,"about_ca_system_score_gemma":0.00017944002,"threshold_uncertainty_score":0.0033938289},"labels":[],"label_agreement":null},{"id":"W2030858021","doi":"10.1016/j.radonc.2009.06.019","title":"Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model","year":2009,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Fluorescence; Chemistry; Cancer research; Pathology; Medicine","score_opus":0.007469662341176826,"score_gpt":0.24343183887542114,"score_spread":0.2359621765342443,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030858021","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98020107,0.0013676377,0.014082912,0.00019002795,0.000043719727,0.000052720865,0.00028087603,0.0002634136,0.003517627],"genre_scores_gemma":[0.9678408,0.0014780054,0.020945229,0.00003710496,0.000028781225,0.0000923291,0.00044601964,0.00016086655,0.008970881],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987304,0.000014775097,0.0000067186147,0.00003781346,0.000027221267,0.000040453917],"domain_scores_gemma":[0.9997694,0.00007366741,0.00006521822,0.000029089282,0.000021295897,0.000041299358],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003607754,0.00047160775,0.00038519508,0.00036160968,0.00025605963,0.00047309406,0.00050432945,0.00060788967,0.0013904241],"category_scores_gemma":[0.0001696377,0.00032664032,0.00024292716,0.00025658705,0.0005133193,0.0005121351,0.00020852768,0.0008756955,0.00027564022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016424604,0.0000130083845,0.0000709003,0.000026710186,0.0000031726713,0.000026158017,0.000018989664,0.00012689493,0.9987569,0.0002084995,0.000035625624,0.00054887787],"study_design_scores_gemma":[0.000017453953,0.000107849,0.00081969454,0.0000030733195,0.000010602644,0.00010209467,0.000017041422,0.0015746963,0.9962578,0.00003842472,0.0010479309,0.0000034191937],"about_ca_topic_score_codex":0.003436438,"about_ca_topic_score_gemma":0.0032070407,"teacher_disagreement_score":0.003436438,"about_ca_system_score_codex":0.00063168036,"about_ca_system_score_gemma":0.00047456424,"threshold_uncertainty_score":0.0068328977},"labels":[],"label_agreement":null},{"id":"W2031579023","doi":"10.1016/s1095-6433(03)00246-0","title":"The comparative physiology of carbonic anhydrase: a tribute to Dr. T.H. Maren","year":2003,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University","funders":"","keywords":"Tribute; Carbonic anhydrase; Physiology; Chemistry; Biology; Biochemistry; History; Art history; Enzyme","score_opus":0.019516974499487305,"score_gpt":0.2892772523550051,"score_spread":0.2697602778555178,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2031579023","genre_codex":"commentary","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0031825225,0.22794761,0.007576803,0.65269625,0.09767025,0.000016990489,0.00008171106,0.00013709917,0.010690841],"genre_scores_gemma":[0.07553658,0.3478298,0.012881284,0.19949588,0.27117285,0.00008786335,0.00019322844,0.00045879252,0.09234374],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99913603,0.00019698791,0.000060907674,0.0002571587,0.00028434867,0.000064709435],"domain_scores_gemma":[0.9959585,0.0013991974,0.0001434574,0.0001891652,0.0011840017,0.0011257442],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0031715413,0.0006580587,0.0012346462,0.00085717393,0.0010592621,0.001984978,0.0011730985,0.002625005,0.004387799],"category_scores_gemma":[0.0039467076,0.00033131053,0.00039869684,0.0008011269,0.0035579924,0.004964656,0.0013833605,0.010835413,0.0025307068],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030019606,0.00006492598,0.0010568132,0.000498773,0.000047262143,0.0006639397,0.0007022486,0.00044271615,0.0050177802,0.041836116,0.7761529,0.17321627],"study_design_scores_gemma":[0.000026344158,0.0001804172,0.0015999429,0.00027500268,0.000016666136,0.0019263362,0.0003387441,0.00034190872,0.001716056,0.024532132,0.9689771,0.000069328686],"about_ca_topic_score_codex":0.0018464704,"about_ca_topic_score_gemma":0.0024602448,"teacher_disagreement_score":0.004387799,"about_ca_system_score_codex":0.0010988944,"about_ca_system_score_gemma":0.0011056956,"threshold_uncertainty_score":0.016772926},"labels":[],"label_agreement":null},{"id":"W2032669985","doi":"10.1021/bc0155420","title":"Identification and Activities of Human Carboxylesterases for the Activation of CPT-11, a Clinically Approved Anticancer Drug","year":2001,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; University of Victoria","keywords":"Prodrug; Carboxylesterase; Chemistry; Conjugate; Pharmacology; Enzyme; Drug; Cytotoxicity; Active metabolite; SN-38; Active site; Biochemistry; Cancer; In vitro; Metabolite; Irinotecan; Colorectal cancer; Medicine; Internal medicine","score_opus":0.015997852989728542,"score_gpt":0.28004717421685743,"score_spread":0.2640493212271289,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2032669985","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9545069,0.015629595,0.02404325,0.00047859928,0.00007215068,0.00029460996,0.0015082612,0.00013532408,0.0033314573],"genre_scores_gemma":[0.97107893,0.0038338862,0.018523818,0.00009971542,0.00004456696,0.000102742175,0.003112356,0.000023930397,0.003180107],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996942,0.00007869448,0.0000381696,0.000056900037,0.00007990957,0.00005208381],"domain_scores_gemma":[0.99983764,0.00004551349,0.000031407857,0.000025436775,0.00003208529,0.000027881046],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045090512,0.0004971464,0.00027297685,0.00038959403,0.000093372975,0.00033201466,0.00015847536,0.00032668986,0.0007933015],"category_scores_gemma":[0.00047859346,0.00017753916,0.00037459578,0.0003760425,0.00016178474,0.0002360046,0.00016982414,0.00039946206,0.00041811675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018954581,0.00011640997,0.00068451284,0.00006267246,0.000015873578,0.000072164396,0.000024485193,0.00021137297,0.9937304,0.00013365701,0.00009343354,0.004665391],"study_design_scores_gemma":[0.000023513361,0.00056840526,0.0039487467,0.000009642725,0.000030009325,0.00053326256,0.00002142039,0.001437029,0.9880067,0.00005207526,0.005361023,0.000007995191],"about_ca_topic_score_codex":0.0004214676,"about_ca_topic_score_gemma":0.0006501718,"teacher_disagreement_score":0.0007933015,"about_ca_system_score_codex":0.0002872794,"about_ca_system_score_gemma":0.00024102817,"threshold_uncertainty_score":0.0026538968},"labels":[],"label_agreement":null},{"id":"W2035123832","doi":"10.1016/j.bmc.2010.03.026","title":"Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Carbonic anhydrase; Enzyme; Active site; Enzyme inhibitor; Biochemistry","score_opus":0.004072900372703977,"score_gpt":0.20761720337365,"score_spread":0.20354430300094603,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035123832","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.925874,0.0222519,0.023269912,0.0019112144,0.00053423684,0.00017734182,0.0006068124,0.0006129567,0.024761712],"genre_scores_gemma":[0.98444635,0.0048329798,0.0027734472,0.00035061495,0.00007911032,0.000039202278,0.00023777691,0.00002967899,0.00721086],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999008,0.000006522117,0.000004388655,0.000022931552,0.000039177477,0.000026065813],"domain_scores_gemma":[0.99995935,0.000012643941,0.000010715045,0.0000042775755,0.0000050889253,0.000007813484],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012505923,0.00028874737,0.00022947475,0.00014170575,0.00024703259,0.00046420752,0.0002841796,0.0005339401,0.0013954857],"category_scores_gemma":[0.00015406708,0.00014644553,0.00017480417,0.000113613256,0.00025869388,0.00042083068,0.0002234982,0.0005880761,0.00030224895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023644196,0.000059126844,0.00013583885,0.00016300337,0.000018651881,0.000106040185,0.00003720643,0.00040447156,0.97958994,0.0042955945,0.0012576641,0.013695929],"study_design_scores_gemma":[0.00007131712,0.00034323716,0.00058601995,0.000012900636,0.00002273258,0.00021282346,0.000013340899,0.0010398885,0.977825,0.00040801568,0.019452969,0.000011683554],"about_ca_topic_score_codex":0.0011096072,"about_ca_topic_score_gemma":0.0017026139,"teacher_disagreement_score":0.0013954857,"about_ca_system_score_codex":0.0004919293,"about_ca_system_score_gemma":0.00023019397,"threshold_uncertainty_score":0.0046684146},"labels":[],"label_agreement":null},{"id":"W2035825135","doi":"10.1080/09687860400014872","title":"Carbonic anhydrase inhibitors that directly inhibit anion transport by the human Cl<sup>−</sup>/HCO<sub>3</sub><sup>−</sup>exchanger, AE1","year":2004,"lang":"en","type":"article","venue":"Molecular Membrane Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Bicarbonate; Carbonic anhydrase; Intracellular pH; DIDS; Antiporter; Organic cation transport proteins; Membrane transport; Biochemistry; Symporter; Substrate (aquarium); Ion transporter; Transporter; Intracellular; Enzyme; Membrane; Biology","score_opus":0.00868121885284778,"score_gpt":0.22134361353627682,"score_spread":0.21266239468342904,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035825135","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9643803,0.028295973,0.0023218654,0.00028798953,0.00016195796,0.00024724368,0.0011154156,0.000113385046,0.0030758372],"genre_scores_gemma":[0.9710136,0.017252214,0.0050965096,0.00022749817,0.00005998139,0.00023052035,0.0016179043,0.0000222202,0.0044795102],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988115,0.00001467789,0.000017960228,0.000023665736,0.000035085402,0.000027488126],"domain_scores_gemma":[0.9999417,0.000013480684,0.00001588387,0.000004111945,0.000010996876,0.000013905517],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570466,0.000396051,0.00039796907,0.00012037063,0.00009512338,0.00017265354,0.00020006362,0.0001926271,0.0010444755],"category_scores_gemma":[0.00012754604,0.0000999752,0.00024700316,0.00017740903,0.00009490992,0.00011857227,0.00008965317,0.0004973334,0.00025837813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00081048784,0.00038190378,0.00069922913,0.00024488458,0.00006760367,0.000118991265,0.000024527384,0.0002241374,0.9798753,0.00014640225,0.00057208125,0.01683442],"study_design_scores_gemma":[0.00037248814,0.0036496252,0.0073836125,0.000014773231,0.00010073407,0.00043142715,0.000023915374,0.0007796009,0.9758261,0.000028310647,0.011381388,0.000008083644],"about_ca_topic_score_codex":0.000982804,"about_ca_topic_score_gemma":0.0045537376,"teacher_disagreement_score":0.0010444755,"about_ca_system_score_codex":0.00033638376,"about_ca_system_score_gemma":0.00030024457,"threshold_uncertainty_score":0.0034941435},"labels":[],"label_agreement":null},{"id":"W2039892803","doi":"10.1016/j.oraloncology.2012.01.018","title":"High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma","year":2012,"lang":"en","type":"article","venue":"Oral Oncology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Occupational Cancer Research Centre; University of Calgary","funders":"","keywords":"Stromal cell; NODAL; Basal cell; Medicine; Metastasis; Cancer research; Internal medicine; Carbonic anhydrase; Oncology; Pathology; Biology; Enzyme; Cancer; Biochemistry","score_opus":0.009495431536883425,"score_gpt":0.22634647658172435,"score_spread":0.21685104504484093,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2039892803","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99921215,0.00041823275,0.00005553968,0.00002413812,0.000003136258,0.0000019527363,0.000032627,0.0000026105317,0.0002497002],"genre_scores_gemma":[0.9997137,0.000105441555,0.000027150123,0.0000060544994,0.0000037604073,0.0000014270868,0.000043791195,7.4204803e-7,0.00009789095],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9999349,0.000011509699,0.0000067219535,0.0000117543605,0.000019750118,0.000015327158],"domain_scores_gemma":[0.99985194,0.000037919668,0.000055063036,0.000007264277,0.000017818309,0.000030073661],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000979476,0.00013957378,0.00023510556,0.00032023844,0.00019500214,0.00025993006,0.00013752199,0.00014742023,0.0006774834],"category_scores_gemma":[0.00042068868,0.00010188552,0.00013932737,0.0004318225,0.00020095434,0.000090987625,0.00011306595,0.00019340376,0.00007115796],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001175197,0.000053801767,0.9554048,0.000037494905,0.0000774396,0.00065905316,0.00007720186,0.00011587781,0.03569158,0.00003772784,0.00012671463,0.0065430645],"study_design_scores_gemma":[0.000014004763,0.00015180666,0.99616516,0.0000023252733,0.00007504053,0.0009092066,0.00010711615,0.00024864887,0.0020179152,0.000028352548,0.00027779528,0.0000026145597],"about_ca_topic_score_codex":0.0019287982,"about_ca_topic_score_gemma":0.0026112238,"teacher_disagreement_score":0.0019287982,"about_ca_system_score_codex":0.00025227162,"about_ca_system_score_gemma":0.00020244672,"threshold_uncertainty_score":0.0038351417},"labels":[],"label_agreement":null},{"id":"W2044456476","doi":"10.1111/j.1399-3054.2006.00849.x","title":"Isolation and characterization of carbonic anhydrases from the marine diatom <i>Phaeodactylum tricornutum</i>","year":2007,"lang":"en","type":"article","venue":"Physiologia Plantarum","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phaeodactylum tricornutum; Biochemistry; Isozyme; Molecular biology; Biology; Polyacrylamide gel electrophoresis; Polyclonal antibodies; Gel electrophoresis; Carbonic anhydrase; Chemistry; Enzyme; Antibody; Algae; Botany","score_opus":0.0058876616801341085,"score_gpt":0.20060087850713934,"score_spread":0.19471321682700524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044456476","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99496126,0.00078157784,0.0015887739,0.000077196586,0.000007990365,0.000040066025,0.0016011433,0.000017354869,0.0009246486],"genre_scores_gemma":[0.96974105,0.0018369063,0.008651837,0.00012126489,0.00002335391,0.00008615237,0.015181303,0.000048315123,0.0043098796],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999155,0.000006064437,0.000013030754,0.000025296478,0.000024260871,0.000015802245],"domain_scores_gemma":[0.9998104,0.000019637251,0.00004465342,0.00002115092,0.000046271794,0.000057907797],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009345546,0.0003997026,0.00023166653,0.0003624432,0.00017988747,0.0003663892,0.00017153916,0.00018155307,0.0003564296],"category_scores_gemma":[0.00025195794,0.00016511708,0.00019404583,0.0004126779,0.00013776336,0.00017481,0.00019652488,0.0003091593,0.00022536048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000022858447,0.000004844104,0.0007048577,0.000017653952,0.0000025637173,0.00004021746,0.000013750199,0.000013506203,0.998539,0.000009053024,0.000011399946,0.0006202538],"study_design_scores_gemma":[0.000028102613,0.00025373066,0.22439948,0.000023305573,0.000056751138,0.0015037125,0.00021621794,0.0007419221,0.7664844,0.000055068227,0.0062217554,0.000015606087],"about_ca_topic_score_codex":0.0054859384,"about_ca_topic_score_gemma":0.009019589,"teacher_disagreement_score":0.0054859384,"about_ca_system_score_codex":0.00038272253,"about_ca_system_score_gemma":0.00028416878,"threshold_uncertainty_score":0.010908067},"labels":[],"label_agreement":null},{"id":"W2046798291","doi":"10.1021/bi801133d","title":"Evolution Reversed: The Ability To Bind Iron Restored to the N-Lobe of the Murine Inhibitor of Carbonic Anhydrase by Strategic Mutagenesis","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Centre for Blood Research, University of British Columbia; National Institute of General Medical Sciences; University of British Columbia","keywords":"Chemistry; Carbonic anhydrase; Biochemistry; Mutant; Mutagenesis; Carbonic anhydrase II; Ferric; Bicarbonate; Stereochemistry; Enzyme; Gene","score_opus":0.009759583413483576,"score_gpt":0.21226381827536608,"score_spread":0.20250423486188251,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2046798291","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98456764,0.00041357582,0.009870649,0.00017519236,0.00011486984,0.000060927312,0.00045145833,0.00018398456,0.004161711],"genre_scores_gemma":[0.9898183,0.00028352856,0.0047990037,0.00010432343,0.000015384727,0.00003665297,0.00061054446,0.00013782557,0.0041945367],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979967,0.00004889624,0.000021493152,0.000040553303,0.000043548192,0.00004595462],"domain_scores_gemma":[0.99980956,0.000046675737,0.00005009878,0.000029384053,0.000022141825,0.00004218974],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019843891,0.00043441658,0.00020669721,0.00020181804,0.00012732501,0.00033741392,0.0003720497,0.00038544636,0.0013755759],"category_scores_gemma":[0.00038738988,0.00013285431,0.00031807082,0.000156742,0.0002859857,0.0001492051,0.0004147439,0.00079955236,0.00059547205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010871447,0.000021361566,0.00031300585,0.000024965297,0.0000142441695,0.00023647254,0.00003635188,0.00019268326,0.9955521,0.0005147286,0.00009230059,0.0028930453],"study_design_scores_gemma":[0.000094901705,0.00090271345,0.011900953,0.000031766693,0.00008036664,0.0032927294,0.00010991963,0.0056896843,0.954587,0.0003874335,0.02288371,0.000038812916],"about_ca_topic_score_codex":0.0012274974,"about_ca_topic_score_gemma":0.0010463643,"teacher_disagreement_score":0.0013755759,"about_ca_system_score_codex":0.00028957165,"about_ca_system_score_gemma":0.0002513056,"threshold_uncertainty_score":0.0046017766},"labels":[],"label_agreement":null},{"id":"W2050063778","doi":"10.1038/435042a","title":"A cadmium enzyme from a marine diatom","year":2005,"lang":"en","type":"article","venue":"Nature","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":615,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Thalassiosira weissflogii; Diatom; Cadmium; Phytoplankton; Carbonic anhydrase; Biota; Enzyme; Biology; Chemistry; Oceanography; Ecology; Nutrient; Biochemistry; Geology","score_opus":0.003348166210697998,"score_gpt":0.2234273521523722,"score_spread":0.2200791859416742,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2050063778","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99050915,0.0017019123,0.005057363,0.00037240545,0.00008627006,0.000023150375,0.00047986882,0.0000395757,0.0017302094],"genre_scores_gemma":[0.9907036,0.0010259282,0.0024602655,0.00007397232,0.000024440285,0.00001084284,0.0012900424,0.000016248354,0.004394686],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998672,0.000012103659,0.00001293879,0.00004226595,0.000041915522,0.00002342492],"domain_scores_gemma":[0.99987936,0.000041138832,0.0000115840485,0.000017345228,0.00002102098,0.000029554174],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014957631,0.00037381877,0.00037953793,0.00020639513,0.0002931732,0.00034474276,0.00024001204,0.00045227015,0.00030699582],"category_scores_gemma":[0.00021527799,0.00017330602,0.00017106808,0.00025575366,0.00024317998,0.00024614882,0.0001946503,0.00049355184,0.00021333153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002698142,0.00002238997,0.0016924846,0.000060744707,0.000007100526,0.00027812904,0.00004596797,0.000104278806,0.9948998,0.0001762487,0.00007955637,0.0023634215],"study_design_scores_gemma":[0.00002384599,0.000115627336,0.011300142,0.000006265006,0.000023917277,0.0011650783,0.00006172369,0.0011305094,0.9827571,0.0001713669,0.0032368132,0.000007600529],"about_ca_topic_score_codex":0.0023910028,"about_ca_topic_score_gemma":0.0015438956,"teacher_disagreement_score":0.0023910028,"about_ca_system_score_codex":0.0004393072,"about_ca_system_score_gemma":0.00029179954,"threshold_uncertainty_score":0.004754126},"labels":[],"label_agreement":null},{"id":"W2050185184","doi":"10.3109/14756366.2013.773994","title":"Synthesis and evaluation of <sup>18</sup>F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography","year":2013,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Positron emission tomography; Chemistry; Carbonic anhydrase; Radiochemistry; Molecular biology; Nuclear medicine; Enzyme; Biochemistry; Medicine; Biology","score_opus":0.00881993144565158,"score_gpt":0.24445037000537378,"score_spread":0.2356304385597222,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2050185184","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8834978,0.014078206,0.08373891,0.00038549845,0.00011864905,0.001872731,0.0021635941,0.0003620682,0.013782565],"genre_scores_gemma":[0.9107154,0.009706573,0.06623415,0.00014619026,0.00004351611,0.0005481283,0.0026577285,0.00013064354,0.009817606],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998828,0.000021805634,0.000010161181,0.000022313163,0.000036234072,0.000026728927],"domain_scores_gemma":[0.99983644,0.00002693842,0.0000295251,0.000016472404,0.000052486812,0.000038057835],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026633107,0.00052580104,0.0004314974,0.00019697813,0.00021461213,0.00031163948,0.0003935842,0.0004782111,0.0009337198],"category_scores_gemma":[0.00028047265,0.00021073311,0.0002104213,0.00024550897,0.00018843883,0.00027859348,0.00009842163,0.00040047074,0.00061076344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022159707,0.000060068793,0.00009806312,0.00010900314,0.000012996823,0.000115903735,0.000023156528,0.00081358384,0.99101627,0.00035042045,0.00013518792,0.007043721],"study_design_scores_gemma":[0.00004272461,0.00048767423,0.0002920463,0.00000665016,0.00002316205,0.0001821508,0.000006599138,0.00057356816,0.99206114,0.00002437683,0.006292626,0.0000072925036],"about_ca_topic_score_codex":0.0017624225,"about_ca_topic_score_gemma":0.00207765,"teacher_disagreement_score":0.0017624225,"about_ca_system_score_codex":0.0004817542,"about_ca_system_score_gemma":0.000557457,"threshold_uncertainty_score":0.0035043955},"labels":[],"label_agreement":null},{"id":"W2052658948","doi":"10.3109/14756366.2014.968146","title":"Carbamoylphosphonates inhibit autotaxin and metastasis formation<i>in vivo</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McMaster University","keywords":"Autotaxin; Lysophosphatidic acid; In vivo; Extracellular; Metastasis; Cancer research; In vitro; Chemistry; Biochemistry; Pharmacology; Melanoma; Cell biology; Biology; Cancer; Medicine; Internal medicine; Receptor","score_opus":0.013750786763790974,"score_gpt":0.23857186954900284,"score_spread":0.22482108278521187,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052658948","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9912202,0.0039227614,0.0021767488,0.00010442646,0.000037979575,0.000039459002,0.0001835799,0.000078069905,0.0022369903],"genre_scores_gemma":[0.99407816,0.0020736707,0.0015566191,0.00004952842,0.000016999096,0.000027962802,0.0002535994,0.000009747499,0.0019337154],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993265,0.000013468265,0.00000429969,0.000010473821,0.00001766722,0.000021478121],"domain_scores_gemma":[0.99995506,0.000010661008,0.000013887626,0.0000039731153,0.000005755358,0.000010683939],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007792014,0.00029318745,0.00017288153,0.0001248425,0.00005351179,0.000116784075,0.00017306245,0.00020216664,0.00092221616],"category_scores_gemma":[0.00009589809,0.00007516286,0.0001521283,0.000085058724,0.0001487786,0.00013519592,0.00009380894,0.00038506291,0.00019493484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002586641,0.000077258665,0.00008993439,0.00004083884,0.00000559914,0.00003886407,0.0000052532077,0.00015676342,0.99651563,0.00010507719,0.00007166825,0.0026344792],"study_design_scores_gemma":[0.00002781284,0.0012149853,0.0008447607,0.0000025828506,0.00000676088,0.00012218245,0.000004270211,0.00044333545,0.9962386,0.000030803538,0.0010620751,0.0000018908346],"about_ca_topic_score_codex":0.00066722167,"about_ca_topic_score_gemma":0.0010189688,"teacher_disagreement_score":0.00092221616,"about_ca_system_score_codex":0.00016750877,"about_ca_system_score_gemma":0.00015876711,"threshold_uncertainty_score":0.0030850768},"labels":[],"label_agreement":null},{"id":"W2056702193","doi":"10.1016/j.copbio.2011.06.006","title":"Biotechnology for the acceleration of carbon dioxide capture and sequestration","year":2011,"lang":"en","type":"review","venue":"Current Opinion in Biotechnology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer","keywords":"Carbonic anhydrase; Carbon dioxide; Biochemical engineering; Combustion; Carbon sequestration; Fossil fuel; Environmental science; Chemistry; Biocatalysis; Enzyme; Carbon fibers; Materials science; Biochemistry; Organic chemistry; Engineering; Catalysis","score_opus":0.0831652199393626,"score_gpt":0.34768946943995876,"score_spread":0.26452424950059616,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056702193","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00033520814,0.9913845,0.0028204916,0.0011763014,0.0011567759,0.000008909857,0.000028185123,0.000032975324,0.0030567178],"genre_scores_gemma":[0.0024690272,0.9928209,0.0012403746,0.00062745175,0.0005183218,0.000016948234,0.00005705315,0.0000074014106,0.0022425386],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9996525,0.000039888073,0.000025162852,0.00009337247,0.0001381072,0.00005091351],"domain_scores_gemma":[0.9996563,0.00015201273,0.000055362736,0.000019803547,0.00008088239,0.000035574387],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011671331,0.001981202,0.001992884,0.00132881,0.00033173943,0.0015820294,0.0019305199,0.0029745672,0.003269265],"category_scores_gemma":[0.0006987869,0.00056400395,0.00067707774,0.0024798526,0.0017771518,0.0028218508,0.0012267138,0.0039377687,0.004111606],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016339119,0.00020062189,0.0001489207,0.012691858,0.00011165863,0.00032696713,0.000046882866,0.0014564767,0.030269265,0.031486277,0.041770544,0.8813271],"study_design_scores_gemma":[0.000039431427,0.000117109565,0.00030631002,0.00088781194,0.000082217586,0.00062641804,0.000028429738,0.00042341062,0.007872576,0.0071603586,0.98241997,0.000036058304],"about_ca_topic_score_codex":0.0009443063,"about_ca_topic_score_gemma":0.0016217058,"teacher_disagreement_score":0.003269265,"about_ca_system_score_codex":0.0016152435,"about_ca_system_score_gemma":0.0011170028,"threshold_uncertainty_score":0.011719465},"labels":[],"label_agreement":null},{"id":"W2057076688","doi":"10.1139/v05-158","title":"Scientific genealogies of physical and mechanistic organic chemists","year":2005,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":true,"route_about_ca":true,"ca_institutions":"","funders":"National Research Council Canada; Royal Society","keywords":"Physical science; Key (lock); Chemistry; Engineering ethics; Epistemology; Sociology; Social science; Engineering; Ecology; Philosophy; Biology","score_opus":0.005976010685081523,"score_gpt":0.2007274411611953,"score_spread":0.1947514304761138,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2057076688","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.59146,0.02590827,0.033718534,0.01222799,0.00048519715,0.000255512,0.0072425934,0.00043983987,0.3282621],"genre_scores_gemma":[0.93812156,0.013095956,0.012565298,0.00062051264,0.00013880146,0.00024476548,0.00290856,0.00007612005,0.032228425],"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","domain_scores_codex":[0.9990388,0.00023749385,0.00006647528,0.00015159925,0.0003745618,0.00013113518],"domain_scores_gemma":[0.9922969,0.0038197406,0.0013109815,0.00070292474,0.0013438942,0.00052552554],"candidate_categories":["bibliometrics"],"consensus_categories":[],"category_scores_codex":[0.0017027557,0.0001783905,0.0002314634,0.007090585,0.0024036167,0.0020702453,0.00050623337,0.0006354577,0.008694181],"category_scores_gemma":[0.009699866,0.00023921087,0.00021676344,0.0064570927,0.0022203317,0.002329197,0.0010938304,0.0009533219,0.0010501347],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020572625,0.00007016057,0.043476537,0.00040464493,0.00011171879,0.0007371585,0.008693503,0.0074141836,0.0016434627,0.65838027,0.024285244,0.25457746],"study_design_scores_gemma":[0.00005116867,0.0001267563,0.08440836,0.0003581955,0.00010633939,0.0023336823,0.0064692087,0.011236636,0.0012749104,0.36925942,0.52425796,0.00011738872],"about_ca_topic_score_codex":0.010077973,"about_ca_topic_score_gemma":0.0109820375,"teacher_disagreement_score":0.99290943,"about_ca_system_score_codex":0.002810721,"about_ca_system_score_gemma":0.0017356954,"threshold_uncertainty_score":0.02908492},"labels":[],"label_agreement":null},{"id":"W2059446431","doi":"10.1016/j.bmcl.2005.08.102","title":"Carbonic anhydrase inhibitors: Inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Isozyme; Carbonic anhydrase; Chemistry; Gene isoform; Cytosol; Enzyme; Stereochemistry; Enzyme inhibitor; Biochemistry; Sulfonamide; Gene","score_opus":0.00448855836320237,"score_gpt":0.18846192748266719,"score_spread":0.18397336911946482,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2059446431","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.933418,0.03390681,0.013218281,0.0007017518,0.00024036168,0.00029909448,0.0016807329,0.0006191757,0.015915768],"genre_scores_gemma":[0.9473719,0.02859162,0.0075088637,0.00042783874,0.00006983669,0.00017238357,0.0028190268,0.00003859747,0.01299999],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999899,0.000011536484,0.000008359101,0.00002394266,0.000030363268,0.000026750296],"domain_scores_gemma":[0.9999548,0.000008086561,0.000009270174,0.0000042350575,0.0000077226405,0.000015830847],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017745132,0.0007822049,0.0004670092,0.00047194006,0.00020439501,0.00021298094,0.0004453188,0.0002994744,0.0012573297],"category_scores_gemma":[0.00015289133,0.00022863374,0.00027903426,0.00035270618,0.00014517475,0.00021187385,0.000194333,0.0004900313,0.0004886341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000598251,0.00023554468,0.000434065,0.00021678294,0.00004755518,0.00032659672,0.000062261286,0.0016793013,0.94977903,0.00089428975,0.0017783619,0.04394802],"study_design_scores_gemma":[0.00034441976,0.0038050355,0.0036478227,0.00006862244,0.00015520611,0.0018176825,0.00003852587,0.0031142752,0.9462288,0.0002517546,0.04048484,0.00004299577],"about_ca_topic_score_codex":0.0009863973,"about_ca_topic_score_gemma":0.0031453378,"teacher_disagreement_score":0.0012573297,"about_ca_system_score_codex":0.0004916431,"about_ca_system_score_gemma":0.00031854148,"threshold_uncertainty_score":0.0042061806},"labels":[],"label_agreement":null},{"id":"W2060578483","doi":"10.1016/j.advenzreg.2009.10.005","title":"Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration","year":2009,"lang":"en","type":"review","venue":"Advances in Enzyme Regulation","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"Chemistry; Cell biology; Cell growth; Biochemistry; Biophysics; Biology","score_opus":0.008995708226938206,"score_gpt":0.25620605774154365,"score_spread":0.24721034951460544,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2060578483","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00030084825,0.9972632,0.00068601995,0.00028381488,0.00028860557,0.000004768263,0.000022677585,0.000015939735,0.0011342043],"genre_scores_gemma":[0.0016792273,0.99565554,0.00055213127,0.00016083987,0.0002711096,0.0000070385154,0.000046353834,0.0000030046979,0.0016248737],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998517,0.000012521808,0.000017082195,0.000029351291,0.00007171743,0.000017621669],"domain_scores_gemma":[0.9998276,0.000048680693,0.000036600235,0.0000067676965,0.000058604764,0.000021715075],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004983449,0.0010534558,0.0012394623,0.0010896169,0.00019250337,0.0008289231,0.00089774467,0.0008259353,0.0018039545],"category_scores_gemma":[0.00039493968,0.0003082728,0.00023468607,0.0017129579,0.00056008826,0.0010358242,0.0005204716,0.0013982009,0.0021488625],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016055633,0.00004354115,0.00015465014,0.004982311,0.000057710935,0.00018997763,0.000023470777,0.00042523662,0.015531379,0.0035736822,0.02460899,0.95024854],"study_design_scores_gemma":[0.000035730478,0.00006397291,0.0006719477,0.00045422532,0.000073005525,0.0007954837,0.00002845679,0.0001550372,0.005028892,0.0014381757,0.9912375,0.000017421919],"about_ca_topic_score_codex":0.0007949792,"about_ca_topic_score_gemma":0.0017645479,"teacher_disagreement_score":0.0018039545,"about_ca_system_score_codex":0.00069907133,"about_ca_system_score_gemma":0.000718637,"threshold_uncertainty_score":0.006034851},"labels":[],"label_agreement":null},{"id":"W2062441195","doi":"10.1016/j.bmcl.2012.03.071","title":"Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Seventh Framework Programme; Canadian Thoracic Society","keywords":"Chemistry; Flavones; Carbonic anhydrase; Stereochemistry; Enzyme; Carbonic Anhydrase I; Coumarin; Active site; Sulfonamide; Thio-; Enzyme inhibitor; Mechanism of action; Structure–activity relationship; Hydrolysis; Biochemistry; Organic chemistry; In vitro","score_opus":0.008946023556571932,"score_gpt":0.22358809134803823,"score_spread":0.2146420677914663,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062441195","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9758246,0.012695819,0.004798413,0.0004626655,0.000137966,0.00010001407,0.0002526123,0.00007646657,0.0056514423],"genre_scores_gemma":[0.9901147,0.0029751235,0.0021220113,0.00017866476,0.000031420597,0.000028183917,0.00020029265,0.0000075246717,0.0043421667],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993086,0.000014591277,0.0000040005007,0.000012914389,0.000015594807,0.000021951992],"domain_scores_gemma":[0.9999192,0.000028157032,0.000016067876,0.000012738417,0.000010670747,0.000013058743],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017332437,0.00025304174,0.00022984373,0.0001898307,0.00012828018,0.00028267124,0.00027587684,0.00041900954,0.0015134455],"category_scores_gemma":[0.00013452901,0.00010244931,0.00035138885,0.00009192698,0.00026269627,0.00033100712,0.0000942376,0.00048525084,0.00024581412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002455556,0.00004228289,0.00017789268,0.000057025336,0.000021656888,0.000058709797,0.000015402635,0.00015637248,0.99453026,0.0011806886,0.00006208192,0.0034521085],"study_design_scores_gemma":[0.00018475944,0.0016273676,0.007391263,0.000009991906,0.000048198897,0.00035748302,0.000028145152,0.00070397585,0.982474,0.0004479136,0.006710111,0.000016650913],"about_ca_topic_score_codex":0.00085022213,"about_ca_topic_score_gemma":0.001859248,"teacher_disagreement_score":0.0015134455,"about_ca_system_score_codex":0.00028013112,"about_ca_system_score_gemma":0.00021346948,"threshold_uncertainty_score":0.0050629973},"labels":[],"label_agreement":null},{"id":"W2063550283","doi":"10.1021/jm3004587","title":"Protein–Protein Interactions: Inhibition of Mammalian Carbonic Anhydrases I–XV by the Murine Inhibitor of Carbonic Anhydrase and Other Members of the Transferrin Family","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Carbonic anhydrase; Transferrin; Carbonic anhydrase II; Biochemistry; Gene isoform; Enzyme; Lactoferrin; Carbonic Anhydrase I; Isozyme; Enzyme inhibitor; Surface plasmon resonance; Protease inhibitor (pharmacology); Molecular biology; Gene","score_opus":0.008901742072271845,"score_gpt":0.23275040017657314,"score_spread":0.2238486581043013,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063550283","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99455404,0.0026347386,0.0013758378,0.00005920086,0.000021154161,0.00003005437,0.0001654637,0.000036550486,0.0011230451],"genre_scores_gemma":[0.99552417,0.00093622686,0.0019011708,0.000032185206,0.000008270001,0.000023374341,0.00038047082,0.0000072301586,0.0011868348],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998481,0.000032891214,0.000012478537,0.000026311263,0.000045639757,0.00003444965],"domain_scores_gemma":[0.99995327,0.00001062135,0.000010613696,0.0000033028186,0.000009544955,0.00001265413],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017892421,0.00024025887,0.00025551725,0.00009392495,0.00009206295,0.00015006016,0.00025623525,0.00021254558,0.00043659404],"category_scores_gemma":[0.00013074599,0.0000742168,0.00019224362,0.0001264108,0.00009718248,0.0000850988,0.00008361477,0.00026623128,0.00013697638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018801924,0.00005077016,0.00017725276,0.000049819424,0.000016876267,0.000023109133,0.000008636941,0.00015878686,0.9980069,0.000034415865,0.00006659795,0.0012188819],"study_design_scores_gemma":[0.000020515079,0.0004318411,0.0016986253,0.0000026422788,0.000017257596,0.000101374084,0.0000047376134,0.0013377067,0.99491125,0.000007697618,0.0014637641,0.0000025297047],"about_ca_topic_score_codex":0.0017102364,"about_ca_topic_score_gemma":0.0021165775,"teacher_disagreement_score":0.0017102364,"about_ca_system_score_codex":0.0003192042,"about_ca_system_score_gemma":0.00015200271,"threshold_uncertainty_score":0.0034005642},"labels":[],"label_agreement":null},{"id":"W2064835525","doi":"10.1073/pnas.0910866107","title":"Structural basis of the oxidative activation of the carboxysomal γ-carbonic anhydrase, CcmM","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":191,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biochemistry; Thioredoxin; Carbonic anhydrase; Cytosol; Chemistry; RuBisCO; Bicarbonate; Active site; Biophysics; Oxidative phosphorylation; Enzyme; Biology","score_opus":0.018035010961484486,"score_gpt":0.2669829752375615,"score_spread":0.248947964276077,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2064835525","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9970578,0.00042178336,0.0011053755,0.00010014296,0.000017849206,0.000016143,0.00013184476,0.00003742955,0.0011116386],"genre_scores_gemma":[0.9977701,0.00024104607,0.0010071787,0.00005219379,0.000007173981,0.000012275933,0.00038230777,0.0000068853733,0.00052097166],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999591,0.0000041170865,0.0000035716178,0.000011298102,0.000014281527,0.0000075750954],"domain_scores_gemma":[0.9999267,0.0000058985956,0.000027344602,0.000005437343,0.000010186972,0.000024587916],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006479765,0.00020469868,0.00011384294,0.000066909764,0.00021302684,0.00017375557,0.0003224313,0.00026586425,0.00048346756],"category_scores_gemma":[0.00015718711,0.00010115945,0.00014694966,0.00007785344,0.00025136935,0.00011470137,0.00020071937,0.00030860628,0.00023581072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011451603,0.000023560362,0.001001694,0.000047025886,0.0000047580866,0.00024388764,0.000030896408,0.00026396787,0.996662,0.0005759507,0.000061001865,0.0009707756],"study_design_scores_gemma":[0.000077193916,0.00035547727,0.048067838,0.000035576366,0.000028340644,0.00120418,0.00020023306,0.0071203033,0.93474174,0.0010009453,0.007147432,0.000020651909],"about_ca_topic_score_codex":0.0010743359,"about_ca_topic_score_gemma":0.00085441035,"teacher_disagreement_score":0.0010743359,"about_ca_system_score_codex":0.00042957565,"about_ca_system_score_gemma":0.00031637624,"threshold_uncertainty_score":0.0031167865},"labels":[],"label_agreement":null},{"id":"W2064991426","doi":"10.1016/j.yjmcc.2011.12.008","title":"Carbonic anhydrase XIV in the normal and hypertrophic myocardium","year":2011,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Agencia Nacional de Promoción Científica y Tecnológica; University of Alberta; Saint Louis University; Consejo Nacional de Investigaciones Científicas y Técnicas; University of Washington","keywords":"Sarcolemma; Immunoprecipitation; Extracellular; Chemistry; Myocyte; Colocalization; Cytosol; Carbonic anhydrase II; Internal medicine; Molecular biology; Endocrinology; Carbonic anhydrase; Biology; Enzyme; Biochemistry; Medicine; Gene","score_opus":0.009646115750474521,"score_gpt":0.18966034329333364,"score_spread":0.18001422754285912,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2064991426","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9941994,0.0038096544,0.0007421009,0.00007265148,0.00001658358,0.0000042745437,0.00006431373,0.000015372729,0.001075646],"genre_scores_gemma":[0.9978928,0.0006920264,0.00024795902,0.000011504907,0.000013142738,0.000004282158,0.00012869688,0.000007284849,0.0010024381],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9998568,0.0000361543,0.00001231513,0.00002184078,0.000030972755,0.000041929878],"domain_scores_gemma":[0.99977976,0.00007165417,0.0000237096,0.000019794568,0.000021441787,0.00008367313],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032026012,0.00018642208,0.00026406633,0.00043095398,0.00014096693,0.0003588986,0.0003328812,0.00024080355,0.00056908256],"category_scores_gemma":[0.00051776675,0.00019782002,0.00010033603,0.0001292784,0.00044420673,0.0002209221,0.00016778852,0.00033655678,0.00010343871],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0035012346,0.000053858515,0.0038647617,0.000053463136,0.000022209224,0.00033315123,0.00008896992,0.00030105686,0.9842929,0.0022439153,0.00011802898,0.0051264833],"study_design_scores_gemma":[0.00018608276,0.0011503675,0.06827651,0.00001591578,0.00008936382,0.0018082875,0.00018720182,0.008272495,0.9146646,0.0012131934,0.0041167974,0.000019084955],"about_ca_topic_score_codex":0.0021239875,"about_ca_topic_score_gemma":0.0017800006,"teacher_disagreement_score":0.0021239875,"about_ca_system_score_codex":0.00059561845,"about_ca_system_score_gemma":0.00028245602,"threshold_uncertainty_score":0.0043215156},"labels":[],"label_agreement":null},{"id":"W2066523850","doi":"10.1016/j.jphotobiol.2013.12.002","title":"Screening of novel chemical compounds as possible inhibitors of carbonic anhydrase and photosynthetic activity of photosystem II","year":2013,"lang":"en","type":"article","venue":"Journal of Photochemistry and Photobiology B Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Bundesministerium für Bildung und Forschung; Russian Academy of Sciences; Russian Foundation for Basic Research; European Cooperation in Science and Technology","keywords":"Photosystem II; Photosynthesis; Carbonic anhydrase; Chemistry; Photosystem I; Enzyme; Biochemistry","score_opus":0.008697001044962923,"score_gpt":0.23854332341963402,"score_spread":0.2298463223746711,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066523850","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9723374,0.012298612,0.0053880643,0.0003614601,0.00011412027,0.00065160554,0.0013508213,0.00018158792,0.007316256],"genre_scores_gemma":[0.97571665,0.010093346,0.0058472045,0.00017583594,0.000071768154,0.00023536541,0.0016216742,0.000021916792,0.006216249],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998946,0.000018712286,0.000008989399,0.000017548617,0.00003114427,0.00002908072],"domain_scores_gemma":[0.9998808,0.000036432302,0.000020757037,0.0000065149993,0.000024570098,0.000030904688],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535414,0.00067626964,0.0005362984,0.0007200745,0.00032484965,0.00028290474,0.000489662,0.00039536596,0.0029255508],"category_scores_gemma":[0.00022564127,0.00035696398,0.00040107954,0.00035995396,0.00020265317,0.00023181744,0.00016646553,0.0005489272,0.00039042684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008173129,0.0007900814,0.0005581898,0.0003770941,0.00007061064,0.00042511965,0.000041393945,0.001483249,0.9820499,0.00044072478,0.00038052318,0.012565939],"study_design_scores_gemma":[0.0007503701,0.0075580394,0.003928937,0.00004546307,0.00025366407,0.00071057054,0.000044120836,0.0022293134,0.9744767,0.00011820248,0.009858759,0.000025849464],"about_ca_topic_score_codex":0.0009192431,"about_ca_topic_score_gemma":0.003255866,"teacher_disagreement_score":0.0029255508,"about_ca_system_score_codex":0.00033650402,"about_ca_system_score_gemma":0.00043001014,"threshold_uncertainty_score":0.009786904},"labels":[],"label_agreement":null},{"id":"W2071127905","doi":"10.2118/99787-ms","title":"Reducing the Permeability of Sandstone Porous Media to Water and CO2: Application of Bovine Carbonic Anhydrase Enzyme","year":2006,"lang":"en","type":"article","venue":"SPE/DOE Symposium on Improved Oil Recovery","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Regina","funders":"","keywords":"Carbonic anhydrase; Chemistry; Permeability (electromagnetism); Porous medium; Carbon dioxide; Chemical engineering; Carbonate; Precipitation; Porosity; Enzyme; Biochemistry; Membrane; Organic chemistry","score_opus":0.003805924620390695,"score_gpt":0.2024374524800134,"score_spread":0.1986315278596227,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2071127905","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9938048,0.00074827357,0.004772051,0.00005442599,0.000017779827,0.000033366217,0.00005240369,0.00005693675,0.00045989492],"genre_scores_gemma":[0.993046,0.0006148501,0.0056075207,0.000017840684,0.0000059756762,0.000015261561,0.00006537132,0.000011919271,0.00061528943],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986625,0.000019513787,0.000013076372,0.00002730949,0.000046887766,0.00002691801],"domain_scores_gemma":[0.99984586,0.000039924107,0.0000518276,0.000013283798,0.000027988104,0.000020994872],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002079039,0.0002945036,0.0002645078,0.0001902879,0.00008782233,0.0002547022,0.00019059479,0.0003049582,0.00021590517],"category_scores_gemma":[0.00026971512,0.00010663631,0.00026022168,0.00013410226,0.0001950408,0.00021037237,0.00015963984,0.00026461072,0.000065562475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000017900604,0.000011623001,0.000043189793,0.000017580964,0.0000014869454,0.000014386159,0.0000040375367,0.000041540963,0.9993636,0.0000051395373,0.0000026302662,0.00047689374],"study_design_scores_gemma":[0.0000018579454,0.00010049252,0.000552162,0.0000012004792,0.0000037828345,0.000021786716,0.000004206853,0.00033980055,0.9987953,0.000002033277,0.00017558226,0.0000017459308],"about_ca_topic_score_codex":0.000939237,"about_ca_topic_score_gemma":0.0014779324,"teacher_disagreement_score":0.000939237,"about_ca_system_score_codex":0.00018593886,"about_ca_system_score_gemma":0.00013692153,"threshold_uncertainty_score":0.0018675923},"labels":[],"label_agreement":null},{"id":"W2072548043","doi":"10.1016/j.seppur.2011.11.005","title":"New scrubber concept for catalytic CO2 hydration by immobilized carbonic anhydrase II and in-situ inhibitor removal in three-phase monolith slurry reactor","year":2011,"lang":"en","type":"article","venue":"Separation and Purification Technology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Monolith; Slurry; Chemistry; Data scrubbing; Chemical engineering; Chromatography; Ion exchange; Catalysis; Materials science; Waste management; Organic chemistry; Ion","score_opus":0.014000542489352619,"score_gpt":0.2667658133660546,"score_spread":0.252765270876702,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2072548043","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.65905887,0.0041002007,0.32630554,0.00059851585,0.0005244054,0.00021786377,0.00038809763,0.0035608762,0.005245593],"genre_scores_gemma":[0.8977804,0.0011280436,0.09304689,0.00025951516,0.0001128636,0.00014439372,0.00035017624,0.00012112321,0.007056499],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998005,0.000013944466,0.000009538828,0.00006752514,0.000072490424,0.000035987934],"domain_scores_gemma":[0.9999082,0.000016233042,0.00001924672,0.000016663957,0.00001873579,0.000020978408],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026867207,0.00052563695,0.00070515554,0.00021168665,0.00027392662,0.0005274747,0.0012900728,0.000652898,0.00087599095],"category_scores_gemma":[0.00011118761,0.00041240733,0.00040365526,0.00014296621,0.00030851626,0.00055604754,0.0003612302,0.00076998974,0.00057952025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000021784203,0.000022406968,0.000023945058,0.000027793156,0.0000040511504,0.000025652502,0.0000076051715,0.00006404285,0.9979518,0.00024658444,0.00007957903,0.0015248418],"study_design_scores_gemma":[0.0000118169955,0.00006431057,0.00024590324,0.0000014627955,0.00000862812,0.000074406315,0.000004331116,0.003741492,0.99378467,0.0000625413,0.001992491,0.000007904359],"about_ca_topic_score_codex":0.00043823122,"about_ca_topic_score_gemma":0.0009354308,"teacher_disagreement_score":0.0012900728,"about_ca_system_score_codex":0.00040118338,"about_ca_system_score_gemma":0.0003472081,"threshold_uncertainty_score":0.0029304624},"labels":[],"label_agreement":null},{"id":"W2073477117","doi":"10.1016/j.jmgm.2014.10.010","title":"Identifying potential selective fluorescent probes for cancer-associated protein carbonic anhydrase IX using a computational approach","year":2014,"lang":"en","type":"article","venue":"Journal of Molecular Graphics and Modelling","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Bank of Canada; Royal Bank of Canada; Lakehead University","keywords":"Virtual screening; Fluorescence; Chemistry; Computational biology; Carbonic anhydrase; Fluorophore; In silico; Combinatorial chemistry; Biochemistry; Biology; Enzyme; Drug discovery","score_opus":0.019896995918730908,"score_gpt":0.2546096962148817,"score_spread":0.23471270029615082,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073477117","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7879207,0.0009949971,0.19804752,0.0008612593,0.000054989512,0.00016939302,0.0003366459,0.00092734734,0.010687199],"genre_scores_gemma":[0.9278073,0.00048056414,0.06965784,0.00013239835,0.00000911123,0.00016823695,0.0002320353,0.000059838178,0.0014527725],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99987924,0.00002960455,0.0000037687348,0.000020298243,0.00004048234,0.000026547928],"domain_scores_gemma":[0.9997799,0.00014002272,0.000023136616,0.000009295675,0.00003056708,0.0000172002],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038998085,0.00056083396,0.0007284102,0.00056429807,0.0005809283,0.0010122234,0.0010138439,0.0010168314,0.0016966801],"category_scores_gemma":[0.00097150716,0.0004129656,0.0007511757,0.000407362,0.00047672918,0.00051436474,0.00055625587,0.00064303994,0.00015703836],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034652618,0.00015910111,0.002182353,0.00024839668,0.0000949193,0.00034902463,0.00007446502,0.92750585,0.035491806,0.013457825,0.000680763,0.019408954],"study_design_scores_gemma":[0.000029863599,0.000026531792,0.00010123856,0.0000027231326,0.000018043382,0.000015702364,0.000015974225,0.9948613,0.003916238,0.0008024322,0.0002060775,0.0000038714925],"about_ca_topic_score_codex":0.0058754454,"about_ca_topic_score_gemma":0.0081788115,"teacher_disagreement_score":0.0058754454,"about_ca_system_score_codex":0.0013822042,"about_ca_system_score_gemma":0.0015412061,"threshold_uncertainty_score":0.011682451},"labels":[],"label_agreement":null},{"id":"W2076853458","doi":"10.1016/j.ijrobp.2010.11.059","title":"High Stromal Carbonic Anhydrase IX Expression Is Associated With Decreased Survival in p16-Negative Head-and-Neck Tumors","year":2011,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary; Alberta Health Services","funders":"","keywords":"Immunohistochemistry; Head and neck squamous-cell carcinoma; Tissue microarray; Tumor hypoxia; Stromal cell; Medicine; Cancer research; Pathology; Oncology; Radiation therapy; Internal medicine; Head and neck cancer","score_opus":0.016367346981522157,"score_gpt":0.2749917531309276,"score_spread":0.25862440614940546,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076853458","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.999468,0.00019951352,0.0000822353,0.00001552029,0.0000019961285,0.0000016421976,0.00003933449,0.000005049794,0.00018669027],"genre_scores_gemma":[0.99949896,0.00009641942,0.000045306348,0.000004250927,0.0000032724204,0.000002341943,0.00007755724,0.0000021246478,0.00026981474],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99991846,0.000011699256,0.000007971735,0.000017036382,0.000023255481,0.000021568561],"domain_scores_gemma":[0.99958557,0.00008412408,0.00018318105,0.000026393029,0.000032720785,0.00008802216],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014157487,0.00014894595,0.00019438322,0.00050883216,0.00019627114,0.00030648697,0.000182725,0.00018121496,0.001286974],"category_scores_gemma":[0.00038654695,0.00015156277,0.00011302423,0.0003605763,0.00033732902,0.00013238603,0.00016076732,0.00025463713,0.00015868492],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0026152025,0.000101929116,0.50613916,0.000058532354,0.00008581696,0.001313406,0.00011377686,0.00015767784,0.483015,0.00010096118,0.00018866998,0.0061098654],"study_design_scores_gemma":[0.00001683951,0.00024729862,0.9759026,0.0000023868795,0.000047265512,0.00236325,0.00009286806,0.00036001095,0.020448046,0.000078413424,0.00043701517,0.0000040560703],"about_ca_topic_score_codex":0.0011577334,"about_ca_topic_score_gemma":0.0013149638,"teacher_disagreement_score":0.001286974,"about_ca_system_score_codex":0.00021765896,"about_ca_system_score_gemma":0.0001821605,"threshold_uncertainty_score":0.0043053627},"labels":[],"label_agreement":null},{"id":"W2079143754","doi":"10.1007/s00360-004-0430-8","title":"Comparative physiology and molecular analysis of carbonic anhydrase from the red blood cells of teleost fish","year":2004,"lang":"en","type":"article","venue":"Journal of Comparative Physiology B","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Carbonic anhydrase; Biology; Vertebrate; Trout; Isozyme; Rainbow trout; Red blood cell; Enzyme; Biochemistry; Cytosol; Gene isoform; Fish <Actinopterygii>; Molecular biology; Gene; Fishery","score_opus":0.012872501779352615,"score_gpt":0.2611879673507553,"score_spread":0.24831546557140266,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2079143754","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9966535,0.0009651364,0.0006323968,0.00008170366,0.0000098284845,0.0000066976836,0.00027231363,0.000011485645,0.0013669707],"genre_scores_gemma":[0.9928161,0.0010082745,0.0008465155,0.000049703678,0.000015527572,0.00001502768,0.0013107314,0.000019914633,0.0039182627],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994564,0.0000037769623,0.000004342558,0.00001541063,0.000014353674,0.00001661038],"domain_scores_gemma":[0.99990976,0.0000147332585,0.00001837722,0.00000799321,0.000020239442,0.000028829654],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007081409,0.00022297393,0.00021949396,0.00039140022,0.00030545928,0.00026838432,0.00023685081,0.00024143571,0.0014702806],"category_scores_gemma":[0.00012660526,0.00017977893,0.0002750774,0.0002531163,0.00027269538,0.00028554135,0.0001777748,0.00039352474,0.0003580236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012850961,0.000003821612,0.0009275034,0.000021410648,0.000005778822,0.00006471724,0.000024625298,0.000018164796,0.9977672,0.00010658525,0.000017618757,0.00091408397],"study_design_scores_gemma":[0.00004692336,0.00040408885,0.39313126,0.000015045669,0.00007662392,0.0022595988,0.00025398144,0.0007147808,0.5975377,0.00025282506,0.0052849078,0.000022187614],"about_ca_topic_score_codex":0.0054426584,"about_ca_topic_score_gemma":0.0053190473,"teacher_disagreement_score":0.0054426584,"about_ca_system_score_codex":0.00058917963,"about_ca_system_score_gemma":0.00036207697,"threshold_uncertainty_score":0.0108219385},"labels":[],"label_agreement":null},{"id":"W2080577190","doi":"10.1097/jto.0000000000000148","title":"Membrane Carbonic Anhydrase IX Expression and Relapse Risk in Resected Stage I–II Non–Small-Cell Lung Cancer","year":2014,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute","keywords":"Medicine; Hazard ratio; Internal medicine; Immunohistochemistry; Pathology; Oncology; Confidence interval","score_opus":0.008483269016617832,"score_gpt":0.3233833252648511,"score_spread":0.31490005624823325,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080577190","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99927276,0.0003053857,0.000036686935,0.000020969634,0.0000032000057,0.0000013790618,0.00004301459,0.0000023159826,0.0003141933],"genre_scores_gemma":[0.99968517,0.00004944879,0.000009753485,0.0000049541986,0.0000024531753,8.082727e-7,0.00006300191,6.2775985e-7,0.00018364939],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9999355,0.000011383057,0.00000553008,0.000014226937,0.000013264973,0.000020143145],"domain_scores_gemma":[0.9998423,0.000035338304,0.00004469635,0.000008897288,0.000017092236,0.000051740597],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011156422,0.00011499717,0.00017221847,0.0001803842,0.00012557139,0.00027947914,0.00011677772,0.0002009051,0.000865082],"category_scores_gemma":[0.0003340008,0.00008141196,0.00017956342,0.0001681521,0.00017017622,0.00012756733,0.00011191926,0.0002662125,0.00012024088],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002273313,0.000071767,0.96414053,0.00002631099,0.00008778597,0.00037842634,0.00007745519,0.00023114588,0.026269428,0.000052571944,0.00020275512,0.0061885286],"study_design_scores_gemma":[0.000009055462,0.00022995863,0.99682754,0.000002010302,0.00005782833,0.00034735288,0.00009834632,0.00032982143,0.0017820662,0.00002686227,0.00028661973,0.0000025501552],"about_ca_topic_score_codex":0.0022477147,"about_ca_topic_score_gemma":0.0030775387,"teacher_disagreement_score":0.0022477147,"about_ca_system_score_codex":0.00032694408,"about_ca_system_score_gemma":0.000120524994,"threshold_uncertainty_score":0.004469216},"labels":[],"label_agreement":null},{"id":"W2081316712","doi":"10.1021/ja017099+","title":"Amplification of Screening Sensitivity through Selective Destruction:  Theory and Screening of a Library of Carbonic Anhydrase Inhibitors","year":2002,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Carbonic anhydrase; Sulfonamide; Dipeptide; Carbonic anhydrase II; Enzyme; Combinatorial chemistry; Acetazolamide; Enzyme inhibitor; Stereochemistry; Biochemistry; Peptide","score_opus":0.00989803864147634,"score_gpt":0.2250927673788418,"score_spread":0.21519472873736545,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081316712","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.27086565,0.002504388,0.7084979,0.0006782124,0.00006846861,0.0002220434,0.0001282218,0.0010314225,0.01600367],"genre_scores_gemma":[0.9219859,0.0016464043,0.071554765,0.00038642198,0.000034081182,0.00029543578,0.000077108365,0.00005883542,0.0039609927],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99935836,0.0001184473,0.000022502,0.00014930648,0.00025791774,0.000093490926],"domain_scores_gemma":[0.99920326,0.00052808993,0.00008788786,0.000071277966,0.00007456826,0.00003485704],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00058987405,0.0005568184,0.00058787037,0.0007210486,0.00026402078,0.0007709008,0.0009733778,0.0006950983,0.0008182006],"category_scores_gemma":[0.0015216513,0.0004822336,0.0005255816,0.00040060346,0.0013384803,0.00081495463,0.0006811584,0.00079210504,0.00029476735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015617699,0.00013258045,0.0010366179,0.00032042686,0.00003876335,0.00034202164,0.00011079021,0.06208152,0.8669975,0.034999672,0.00049154164,0.033292394],"study_design_scores_gemma":[0.00003761782,0.00043672638,0.0005784118,0.000018053808,0.000039107694,0.00033009597,0.000023350309,0.46785614,0.51749533,0.009889735,0.003256385,0.000038945193],"about_ca_topic_score_codex":0.0005201455,"about_ca_topic_score_gemma":0.00038869644,"teacher_disagreement_score":0.0011757783,"about_ca_system_score_codex":0.0011757783,"about_ca_system_score_gemma":0.00035733104,"threshold_uncertainty_score":0.008530915},"labels":[],"label_agreement":null},{"id":"W2081341762","doi":"10.1016/j.radonc.2009.06.018","title":"Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment","year":2009,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"KWF Kankerbestrijding","keywords":"Carbonic anhydrase; Carbonic anhydrase II; Chemistry; Cancer research; Cell biology; Enzyme; Biochemistry; Biology","score_opus":0.009484942194658806,"score_gpt":0.24766484649043516,"score_spread":0.23817990429577635,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081341762","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99443936,0.0010720561,0.0027150114,0.00015765803,0.000048984737,0.00001492479,0.00061568286,0.00011491314,0.000821396],"genre_scores_gemma":[0.99562883,0.00042969277,0.0010533463,0.000034661007,0.000009409029,0.000017756252,0.00054630707,0.000025346348,0.0022546411],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973863,0.000032577012,0.000033286768,0.000045935434,0.00007727944,0.00007235775],"domain_scores_gemma":[0.99969566,0.00004257909,0.000088138884,0.00006129477,0.000025461582,0.000086839806],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015186727,0.00036573817,0.0005902807,0.00033388557,0.00019440231,0.00040091656,0.0003680777,0.0003753017,0.002296078],"category_scores_gemma":[0.00012651354,0.00020204677,0.0003935062,0.00029374423,0.00042048222,0.0002577699,0.00025231828,0.000824591,0.0006023429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002133492,0.000020664309,0.00016262002,0.000011351251,0.000005742525,0.00009300878,0.000005467633,0.000035144938,0.99899083,0.00005958701,0.000029685518,0.00037247338],"study_design_scores_gemma":[0.000010419857,0.00015207555,0.0045105056,0.0000020501718,0.00001683749,0.0005890474,0.000028036067,0.00041792428,0.9933947,0.000039460836,0.0008353338,0.0000037171787],"about_ca_topic_score_codex":0.00077527756,"about_ca_topic_score_gemma":0.00073440204,"teacher_disagreement_score":0.002296078,"about_ca_system_score_codex":0.00029501898,"about_ca_system_score_gemma":0.00017630919,"threshold_uncertainty_score":0.007681191},"labels":[],"label_agreement":null},{"id":"W2081559495","doi":"10.1242/jeb.02111","title":"Tribute to R. G. Boutilier: Evidence of a high activity carbonic anhydrase isozyme in the red blood cells of an ancient vertebrate, the sea lamprey <i>Petromyzon marinus</i>","year":2006,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"","keywords":"Isozyme; Lamprey; Carbonic anhydrase; Vertebrate; Petromyzon; Biology; Biochemistry; Enzyme; Red blood cell; Gene","score_opus":0.010053697621580754,"score_gpt":0.25980661654072296,"score_spread":0.2497529189191422,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081559495","genre_codex":"editorial","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.033938695,0.06292478,0.0061776475,0.33962402,0.46945643,0.00027100474,0.0016370089,0.002717211,0.08325324],"genre_scores_gemma":[0.14213657,0.023441367,0.010373433,0.089126356,0.3267137,0.00038500008,0.0039172755,0.0025152932,0.40139097],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99927515,0.00010249172,0.000084514766,0.00030062173,0.00015964256,0.00007765117],"domain_scores_gemma":[0.99727625,0.0009867123,0.00033498212,0.00026954123,0.0006235101,0.00050888705],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00087302737,0.0010401683,0.001508889,0.0012812439,0.0013230451,0.0019599071,0.004866616,0.0047612335,0.05258799],"category_scores_gemma":[0.0049350783,0.00041727995,0.0006449048,0.001109854,0.0022024203,0.0011435557,0.0019136335,0.0032511514,0.053101216],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017648669,0.00009331584,0.001577287,0.000392626,0.00004647333,0.0021943932,0.0003555739,0.00015596864,0.004941718,0.0010889021,0.92603177,0.062945485],"study_design_scores_gemma":[0.000037119957,0.000130702,0.011835169,0.0002006709,0.00003434119,0.0038345659,0.00027256596,0.0005764331,0.0022910824,0.00066519744,0.9800938,0.000028326956],"about_ca_topic_score_codex":0.0039371103,"about_ca_topic_score_gemma":0.003650589,"teacher_disagreement_score":0.05258799,"about_ca_system_score_codex":0.0013948027,"about_ca_system_score_gemma":0.0008224361,"threshold_uncertainty_score":0.17592436},"labels":[],"label_agreement":null},{"id":"W2083280883","doi":"10.1007/s11120-014-0018-4","title":"Identification and characterization of a carboxysomal γ-carbonic anhydrase from the cyanobacterium Nostoc sp. PCC 7120","year":2014,"lang":"en","type":"article","venue":"Photosynthesis Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph; University of Toronto","funders":"Australian Research Council; Natural Sciences and Engineering Research Council of Canada; National Science Foundation","keywords":"Biochemistry; RuBisCO; Chemistry; Carbonic anhydrase; Active site; Pepstatin; Thermophile; Nostoc; Tris; Tricine; Enzyme; Biology; Cyanobacteria; Protease","score_opus":0.01975795246989265,"score_gpt":0.2736043415948902,"score_spread":0.2538463891249976,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083280883","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99033725,0.0013663621,0.004394925,0.00030855337,0.00003804347,0.00006984504,0.0020307426,0.000057468686,0.0013968629],"genre_scores_gemma":[0.97984934,0.0014157064,0.006571687,0.00013661663,0.000030028095,0.000031556025,0.0083948495,0.000039588802,0.0035306374],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997489,0.000016713197,0.000027269381,0.000058466732,0.00010652566,0.000042061598],"domain_scores_gemma":[0.9994506,0.000077684956,0.000118818825,0.00006393793,0.00015997865,0.00012900379],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018672219,0.00050769537,0.00038241074,0.000528105,0.00026691676,0.0005203193,0.00036748286,0.00038225457,0.00033252029],"category_scores_gemma":[0.000602454,0.00017308736,0.0003373882,0.0006510383,0.00026710998,0.00039884239,0.00025930826,0.00036717995,0.0003333026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000374783,0.000019885638,0.00086514984,0.000027851878,0.0000050598355,0.00015573959,0.0000470533,0.00004756298,0.99704725,0.00003940493,0.00003182447,0.0016756698],"study_design_scores_gemma":[0.000028954943,0.00030751014,0.08859543,0.00001973219,0.00007923488,0.0025067271,0.00037873612,0.0010277369,0.8979038,0.00013442774,0.008984429,0.000033212204],"about_ca_topic_score_codex":0.018116452,"about_ca_topic_score_gemma":0.012037975,"teacher_disagreement_score":0.018116452,"about_ca_system_score_codex":0.00063132885,"about_ca_system_score_gemma":0.0009485982,"threshold_uncertainty_score":0.036022007},"labels":[],"label_agreement":null},{"id":"W2084303335","doi":"10.1002/bmb.2006.494034052656","title":"Fluorescence analysis of sulfonamide binding to carbonic anhydrase","year":2006,"lang":"en","type":"article","venue":"Biochemistry and Molecular Biology Education","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"University of Toronto","keywords":"Fluorophore; Chemistry; Fluorescence; Carbonic anhydrase II; Ligand (biochemistry); Carbonic anhydrase; Förster resonance energy transfer; Binding constant; Fluorescence spectroscopy; Tryptophan; Affinities; Binding site; Biophysics; Enzyme; Stereochemistry; Biochemistry; Biology; Receptor; Amino acid","score_opus":0.0036263632993384803,"score_gpt":0.25414250616434647,"score_spread":0.250516142865008,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084303335","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98643154,0.0005020522,0.01082917,0.0000860411,0.000015575195,0.00004311434,0.00012298355,0.000103635844,0.0018659941],"genre_scores_gemma":[0.98389935,0.00057599874,0.012315049,0.000045186967,0.000015558402,0.00006033913,0.0002400884,0.00002097865,0.00282734],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997744,0.000049842067,0.0000071980785,0.000043929966,0.00008419931,0.00004059039],"domain_scores_gemma":[0.9997261,0.00013380975,0.000027618733,0.000020337664,0.00005048822,0.000041510477],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002786732,0.00028346985,0.00029902335,0.00014047757,0.00034097585,0.00016352223,0.0004394871,0.0004085345,0.0011399616],"category_scores_gemma":[0.0003746727,0.00009678684,0.00013645753,0.00019101905,0.00023385447,0.00010467516,0.000112224676,0.0004546831,0.00019214377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000032231223,0.000016972905,0.00008675773,0.000014036026,0.0000020481523,0.000018551158,0.00001339709,0.0000652677,0.9992262,0.000054852997,0.000017260361,0.00045235947],"study_design_scores_gemma":[0.000009459454,0.00029747814,0.0018006752,0.0000015362872,0.000003530057,0.00008504842,0.000024951616,0.0014410884,0.9956806,0.000028919909,0.00062187994,0.0000048485176],"about_ca_topic_score_codex":0.0027162677,"about_ca_topic_score_gemma":0.0021362903,"teacher_disagreement_score":0.0027162677,"about_ca_system_score_codex":0.00048466588,"about_ca_system_score_gemma":0.00031281618,"threshold_uncertainty_score":0.0054008365},"labels":[],"label_agreement":null},{"id":"W2084704553","doi":"10.1158/0008-5472.can-11-2520","title":"Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Extracellular; Intracellular pH; Dephosphorylation; Carbonic anhydrase; Cotransporter; Phosphorylation; Tumor microenvironment; Bicarbonate; Intracellular; Chemistry; Cell biology; Biochemistry; Biology; Enzyme; Phosphatase; Sodium; Cancer research; Tumor cells","score_opus":0.07212802017520464,"score_gpt":0.3431796983774124,"score_spread":0.27105167820220777,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084704553","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99750644,0.0005757901,0.0009411261,0.00006968393,0.000009356215,0.000008211341,0.000050606915,0.000021200452,0.000817463],"genre_scores_gemma":[0.9984061,0.00033837504,0.000410887,0.000013961559,0.000004527276,0.000009034682,0.00006578274,0.0000073148767,0.0007439561],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994326,0.000009281462,0.0000037655595,0.000012347548,0.0000095715395,0.00002177169],"domain_scores_gemma":[0.99993956,0.000009160129,0.000017733428,0.000005480023,0.000005864965,0.000022220313],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000092483286,0.00016535657,0.00014234455,0.000094076255,0.00013143687,0.00019979409,0.000110669105,0.00012392721,0.00059911143],"category_scores_gemma":[0.00011747746,0.00008778775,0.000092526505,0.000062209874,0.0002460545,0.0001267345,0.00014567118,0.00023440296,0.00017922575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008630835,0.000006367411,0.00010013623,0.0000065825857,0.0000010359006,0.000010276172,0.0000051073152,0.000032345637,0.9993401,0.00006892884,0.000011655561,0.0003311915],"study_design_scores_gemma":[0.0000142874205,0.000093867566,0.0055129454,0.0000016916767,0.0000057188417,0.000077365934,0.000015970114,0.0011238083,0.99228305,0.00008048083,0.00078838476,0.0000025402342],"about_ca_topic_score_codex":0.0007799448,"about_ca_topic_score_gemma":0.0008392344,"teacher_disagreement_score":0.0007799448,"about_ca_system_score_codex":0.0003812363,"about_ca_system_score_gemma":0.00020997436,"threshold_uncertainty_score":0.0027660131},"labels":[],"label_agreement":null},{"id":"W2088320251","doi":"10.1016/j.jmgm.2014.02.007","title":"Designing of multi-targeted molecules using combination of molecular screening and in silico drug cardiotoxicity prediction approaches","year":2014,"lang":"en","type":"article","venue":"Journal of Molecular Graphics and Modelling","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"In silico; Computational biology; Docking (animal); Chemistry; Carbonic anhydrase; Isozyme; Cardiotoxicity; Drug; Combinatorial chemistry; Biochemistry; Pharmacology; Enzyme; Biology; Gene; Medicine; Toxicity; Organic chemistry","score_opus":0.03234236996232408,"score_gpt":0.22837654440123173,"score_spread":0.19603417443890764,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088320251","genre_codex":"methods","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":"methods","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.43148565,0.00155973,0.55761856,0.00026299054,0.000053543416,0.00067775615,0.00049290725,0.002677249,0.005171632],"genre_scores_gemma":[0.75082684,0.0012615041,0.24500424,0.00014641233,0.000010297215,0.00041075065,0.0005691038,0.00015242067,0.0016185215],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.999821,0.000040818482,0.000013541082,0.000041276056,0.00005635337,0.000026974612],"domain_scores_gemma":[0.9998609,0.000051842413,0.000029006036,0.000014648884,0.00002841944,0.000015224718],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043959374,0.0010942911,0.0012523445,0.0005150975,0.00025974328,0.0006908018,0.0006213084,0.00052790693,0.0016858877],"category_scores_gemma":[0.0005717368,0.0005325475,0.00082844886,0.00030720135,0.00017526194,0.00046438476,0.00044230386,0.00060645567,0.0005038156],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037964399,0.00039835548,0.0027562075,0.00049723184,0.00019538996,0.00043183385,0.000052795753,0.35958448,0.5496974,0.0031552797,0.000731568,0.08211974],"study_design_scores_gemma":[0.00008512108,0.00056720094,0.00074624346,0.000015295349,0.00017879541,0.00019318111,0.000026950522,0.7691635,0.22544037,0.00088690757,0.0026600847,0.000036316454],"about_ca_topic_score_codex":0.00071975245,"about_ca_topic_score_gemma":0.0014860174,"teacher_disagreement_score":0.0016858877,"about_ca_system_score_codex":0.00041474306,"about_ca_system_score_gemma":0.0005378157,"threshold_uncertainty_score":0.005639851},"labels":[],"label_agreement":null},{"id":"W2088329802","doi":"10.1080/05704920903178421","title":"A Brief Overview of the Effect of High Pressures on the Vibrational Spectra of Biomaterials","year":2009,"lang":"en","type":"article","venue":"Applied Spectroscopy Reviews","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan; McGill University","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Raman spectroscopy; Supercritical fluid; Chemistry; High pressure; Diamond anvil cell; Diamond; Nanotechnology; Materials science; Organic chemistry; Engineering physics","score_opus":0.014677467931772327,"score_gpt":0.2746307503637476,"score_spread":0.2599532824319753,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088329802","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.015087,0.936516,0.022272099,0.00076087564,0.00073806336,0.00008029228,0.00034365663,0.00027445992,0.023927528],"genre_scores_gemma":[0.046453983,0.9012929,0.022794908,0.00070427195,0.0015323708,0.00014431201,0.0006708307,0.000078475816,0.02632795],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99983144,0.000023473838,0.000014846234,0.00003609667,0.000076455,0.000017720895],"domain_scores_gemma":[0.99987066,0.00006418625,0.000014676001,0.0000068572817,0.000032885586,0.000010693913],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029915763,0.00080363284,0.0006560079,0.0011901492,0.0002550755,0.00057014043,0.00041183672,0.00069516915,0.0031739103],"category_scores_gemma":[0.00017343578,0.00035960771,0.00035524112,0.0008364241,0.0001749212,0.00063048344,0.00028470546,0.0008889545,0.0023242403],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023197854,0.00029505536,0.00035191866,0.008527649,0.000089724024,0.0005151899,0.00015274978,0.0016541417,0.41548622,0.005966151,0.01397172,0.55275744],"study_design_scores_gemma":[0.000019720177,0.0010561019,0.0031114952,0.000622964,0.00006465824,0.002445275,0.00009724836,0.001635427,0.1361053,0.003637571,0.85111475,0.00008959913],"about_ca_topic_score_codex":0.0004027627,"about_ca_topic_score_gemma":0.00038847342,"teacher_disagreement_score":0.0031739103,"about_ca_system_score_codex":0.00033856105,"about_ca_system_score_gemma":0.00019724615,"threshold_uncertainty_score":0.010617793},"labels":[],"label_agreement":null},{"id":"W2090706259","doi":"10.1139/b05-078","title":"Identification and characterization of a new carbonic anhydrase in the marine diatom <i>Phaeodactylum tricornutum</i>","year":2005,"lang":"en","type":"article","venue":"Canadian Journal of Botany","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Kato Memorial Bioscience Foundation","keywords":"Phaeodactylum tricornutum; Biochemistry; Biology; Complementary DNA; Neurospora crassa; Amino acid; Carbonic anhydrase; Peptide sequence; Saccharomyces cerevisiae; Diatom; Molecular biology; Enzyme; Yeast; Gene; Botany","score_opus":0.005702834201916054,"score_gpt":0.19918030261274777,"score_spread":0.19347746841083172,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2090706259","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952785,0.0011157432,0.0017140608,0.000106374464,0.000014368594,0.000026524724,0.0010699985,0.000030321897,0.00064411334],"genre_scores_gemma":[0.9796998,0.0012828576,0.007201737,0.000153238,0.000034921104,0.00007297833,0.008058477,0.000033971424,0.003462129],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993026,0.0000037523973,0.000006883914,0.000027842361,0.000021610262,0.000009604542],"domain_scores_gemma":[0.9998048,0.000019843204,0.00004755922,0.000013941215,0.000043801403,0.000070021226],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000058193178,0.00029490874,0.00023929958,0.00027774432,0.0001602838,0.00040204555,0.00013508665,0.00029623884,0.0003442314],"category_scores_gemma":[0.00016286122,0.00015425331,0.00023590942,0.00026480303,0.0001314296,0.00016156012,0.00019069495,0.00030499048,0.00029660086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000020478014,0.000003974773,0.00056097534,0.000023043689,0.0000021866829,0.00005820001,0.00001413365,0.000011827478,0.9985897,0.000009927985,0.00001340707,0.0006921953],"study_design_scores_gemma":[0.000060183374,0.0005655509,0.24700128,0.000039617575,0.000108926986,0.003641603,0.00031649796,0.0020137145,0.72794056,0.00010253962,0.0181784,0.00003108602],"about_ca_topic_score_codex":0.001651938,"about_ca_topic_score_gemma":0.002032445,"teacher_disagreement_score":0.001651938,"about_ca_system_score_codex":0.00029686312,"about_ca_system_score_gemma":0.000243824,"threshold_uncertainty_score":0.0032846332},"labels":[],"label_agreement":null},{"id":"W2090839913","doi":"10.1242/jeb.01551","title":"Cytoplasmic carbonic anhydrase isozymes in rainbow trout<i>Oncorhynchus mykiss</i>: comparative physiology and molecular evolution","year":2005,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University; University of Ottawa; Queen's University","funders":"","keywords":"Isozyme; Carbonic anhydrase; Rainbow trout; Gill; Cytoplasm; Gene isoform; Biology; Trout; Biochemistry; Acetazolamide; Molecular biology; Enzyme; Zoology; Gene; Fish <Actinopterygii>; Physiology; Fishery","score_opus":0.009335742549395355,"score_gpt":0.2749348194667344,"score_spread":0.2655990769173391,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2090839913","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99890673,0.00018613525,0.0003524067,0.000017598519,0.0000028509355,0.0000061100927,0.0001997814,0.000015564741,0.00031279706],"genre_scores_gemma":[0.9956369,0.00024918932,0.0011806419,0.000030178015,0.0000047745502,0.000021872778,0.0012119625,0.000016443468,0.0016480511],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9999385,0.000002009147,0.0000046220407,0.00002730615,0.000016542128,0.000011022911],"domain_scores_gemma":[0.9998888,0.0000060080165,0.000050022307,0.000004092441,0.000020426565,0.000030715797],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007795083,0.00018024047,0.00016403773,0.00048485858,0.00015506544,0.00023331241,0.00012539956,0.00016519787,0.00044074195],"category_scores_gemma":[0.00009341269,0.00012812212,0.00022622073,0.0002673265,0.00021293243,0.00013271857,0.00021223495,0.00023513044,0.0001571098],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012471223,0.000011029799,0.01588866,0.000020037402,0.000009930346,0.00005482565,0.00008310962,0.00004129098,0.9814043,0.000057638226,0.00003123311,0.0022732404],"study_design_scores_gemma":[0.000018082288,0.00020516479,0.9573572,0.000005101404,0.000030659725,0.00045550894,0.00013570474,0.00040928085,0.040326748,0.000047958758,0.0009945193,0.000014087336],"about_ca_topic_score_codex":0.013163059,"about_ca_topic_score_gemma":0.018879754,"teacher_disagreement_score":0.013163059,"about_ca_system_score_codex":0.00062031293,"about_ca_system_score_gemma":0.00035209086,"threshold_uncertainty_score":0.026172876},"labels":[],"label_agreement":null},{"id":"W2094634740","doi":"10.1577/h03-074.1","title":"Effect of Sample Handling on Thiamine and Thiaminolytic Activity in Alewife","year":2005,"lang":"en","type":"article","venue":"Journal of Aquatic Animal Health","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Fisheries and Oceans Canada; Environment and Climate Change Canada; Canadian Water and Wastewater Association","funders":"Great Lakes Fishery Trust","keywords":"Biology; Thiamine; Alewife; Sample (material); Zoology; Fish <Actinopterygii>; Fishery; Biochemistry; Chemistry; Chromatography","score_opus":0.011875488493951425,"score_gpt":0.30369730025424774,"score_spread":0.2918218117602963,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2094634740","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9987054,0.00018184591,0.00039210895,0.000017436882,0.000007800606,0.00003353356,0.0002197626,0.000010511418,0.00043161472],"genre_scores_gemma":[0.9935322,0.00027688165,0.0029915443,0.0001205686,0.00001063419,0.00014623361,0.0012106127,0.000032380514,0.001678827],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.99955183,0.00004880633,0.00003936424,0.00014835355,0.00013795824,0.00007373029],"domain_scores_gemma":[0.99946326,0.00008519561,0.0001514005,0.00005119364,0.00019793125,0.00005099561],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043832796,0.00071681075,0.0003782636,0.00066006393,0.00079560484,0.0008935844,0.00034269114,0.00050554425,0.00097179733],"category_scores_gemma":[0.0011290782,0.0003589867,0.00033368985,0.00048449056,0.0006779985,0.00028938727,0.0004473133,0.00040834022,0.00033290408],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0026621628,0.00024399773,0.18653294,0.00012727774,0.00017545174,0.00039312543,0.00083347206,0.00014805648,0.799695,0.000044525554,0.00012809591,0.009016022],"study_design_scores_gemma":[0.000018771389,0.0012472457,0.8417393,0.000026536229,0.00013160429,0.00045821554,0.00040825762,0.0005558345,0.15360464,0.000036030462,0.0017527923,0.00002080504],"about_ca_topic_score_codex":0.009264949,"about_ca_topic_score_gemma":0.026905876,"teacher_disagreement_score":0.009264949,"about_ca_system_score_codex":0.00053057226,"about_ca_system_score_gemma":0.00035504103,"threshold_uncertainty_score":0.018422008},"labels":[],"label_agreement":null},{"id":"W2096072959","doi":"10.4161/cc.25842","title":"Carbonic anhydrase 9 (CA9) and redox signaling in cancer-associated fibroblasts: Therapeutic implications","year":2013,"lang":"en","type":"letter","venue":"Cell Cycle","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Biology; Carbonic anhydrase; Epithelial–mesenchymal transition; Cancer; Cancer research; Enzyme; Cancer cell; Cell biology; Biochemistry; Genetics; Metastasis","score_opus":0.010684075250093917,"score_gpt":0.23306292400796225,"score_spread":0.22237884875786834,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2096072959","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.017875459,0.015820667,0.00164007,0.9139006,0.032297842,0.00007728616,0.00015900083,0.00021165254,0.018017316],"genre_scores_gemma":[0.31297225,0.048629772,0.004347717,0.39665475,0.14128427,0.0003736405,0.00022749392,0.00010649199,0.095403574],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99973124,0.000057189176,0.000028310533,0.000029008637,0.000108795204,0.000045388933],"domain_scores_gemma":[0.99953103,0.00027935416,0.000046774123,0.000019999501,0.00004892251,0.0000737901],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004536698,0.00047122355,0.0005083779,0.00021583024,0.00073276483,0.000928864,0.00041607127,0.007793944,0.0042628045],"category_scores_gemma":[0.0015639286,0.00023379385,0.00054903445,0.00018391605,0.000818277,0.00055710133,0.00021746085,0.006142303,0.0017477566],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001456862,0.00046751165,0.001643893,0.00046747265,0.000059760365,0.040071044,0.00014020449,0.0005787651,0.043675717,0.016872663,0.803539,0.091027014],"study_design_scores_gemma":[0.0011521387,0.0008977386,0.0034868177,0.000223758,0.00013035593,0.03898193,0.00019654963,0.003870853,0.04086631,0.014744435,0.8953844,0.000064838496],"about_ca_topic_score_codex":0.0005458414,"about_ca_topic_score_gemma":0.0010407036,"teacher_disagreement_score":0.007793944,"about_ca_system_score_codex":0.0015415598,"about_ca_system_score_gemma":0.00038268097,"threshold_uncertainty_score":0.0142605305},"labels":[],"label_agreement":null},{"id":"W2096213157","doi":"10.1111/j.1742-4658.2004.04530.x","title":"Determination of the metal ion dependence and substrate specificity of a hydratase involved in the degradation pathway of biphenyl/chlorobiphenyl","year":2005,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph","funders":"University of Guelph; Ontario Innovation Trust","keywords":"Chemistry; Divalent; Substrate (aquarium); Metal; Biphenyl; Stereochemistry; Metal ions in aqueous solution; Enzyme; Inorganic chemistry; Medicinal chemistry; Organic chemistry","score_opus":0.0169441641276282,"score_gpt":0.23163981895392655,"score_spread":0.21469565482629835,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2096213157","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952703,0.00079280796,0.002698102,0.000060313243,0.000009650625,0.00001833142,0.00051309145,0.000044019518,0.00059350714],"genre_scores_gemma":[0.9931902,0.00040535425,0.0032850392,0.000018731847,0.0000062789913,0.000013729812,0.0017596734,0.00002544542,0.0012955148],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997377,0.000057405767,0.000030131658,0.00004863622,0.000078626486,0.000047471112],"domain_scores_gemma":[0.99973315,0.0000776638,0.000054447093,0.00002573,0.000065298016,0.00004368818],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017380065,0.00034843964,0.0002725163,0.0001999471,0.00008847959,0.0002618768,0.00023434106,0.00025411329,0.00045592763],"category_scores_gemma":[0.00033914414,0.00013951641,0.00016764666,0.0003149222,0.0001669233,0.00018310451,0.00018826067,0.00026996108,0.0003540971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003545672,0.0000145648055,0.00023883386,0.000011131242,0.000001938107,0.000010645713,0.000006117926,0.000014526865,0.99931586,0.000009081338,0.000006099249,0.00033573827],"study_design_scores_gemma":[0.0000043977107,0.00008776511,0.009525623,0.000002357569,0.000008634746,0.00014389132,0.000028358481,0.0005515742,0.9888876,0.000015086693,0.0007412597,0.0000035639296],"about_ca_topic_score_codex":0.0016865836,"about_ca_topic_score_gemma":0.0013876191,"teacher_disagreement_score":0.0016865836,"about_ca_system_score_codex":0.0002313758,"about_ca_system_score_gemma":0.00013996066,"threshold_uncertainty_score":0.0033535361},"labels":[],"label_agreement":null},{"id":"W2097703725","doi":"10.1016/j.ejmech.2011.08.034","title":"Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network; Hôpital Saint-François d'Assise; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Stereochemistry; Structure–activity relationship; Quantitative structure–activity relationship; In vitro; Pharmacology; Biochemistry","score_opus":0.03786759427312126,"score_gpt":0.2471409432391256,"score_spread":0.20927334896600436,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2097703725","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9546028,0.030638637,0.0055137943,0.00024087625,0.00009881969,0.00006876145,0.0006572975,0.00018921512,0.007989832],"genre_scores_gemma":[0.97538847,0.015573955,0.0034125515,0.000098348086,0.00003073366,0.00005266534,0.00067239435,0.000013967015,0.0047569126],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999882,0.000038658884,0.000008952225,0.000011873567,0.000029997254,0.00002849133],"domain_scores_gemma":[0.9999306,0.000018873312,0.0000176611,0.000005106811,0.000011315627,0.000016487127],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033431745,0.00034908514,0.0002786142,0.00024957638,0.00010671921,0.00017375658,0.00035940725,0.00017168249,0.0014907442],"category_scores_gemma":[0.00019225298,0.00015968124,0.00012053464,0.00031219886,0.00018052253,0.000188337,0.00014451332,0.00041052516,0.0003593531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009975976,0.00020945616,0.00040082357,0.00029573002,0.000024198978,0.00014295812,0.00006438179,0.0012160372,0.97569907,0.0016337062,0.0005985659,0.018717442],"study_design_scores_gemma":[0.00030776844,0.0044367816,0.005096655,0.000038786522,0.000086267595,0.0004110823,0.000043954744,0.003460114,0.9716438,0.00020510714,0.014242799,0.000026873173],"about_ca_topic_score_codex":0.0009754377,"about_ca_topic_score_gemma":0.0039013675,"teacher_disagreement_score":0.0014907442,"about_ca_system_score_codex":0.00040763395,"about_ca_system_score_gemma":0.00027970597,"threshold_uncertainty_score":0.0049870014},"labels":[],"label_agreement":null},{"id":"W2098139034","doi":"10.1002/prot.22411","title":"Crystal structure of human carbonic anhydrase‐related protein VIII reveals the basis for catalytic silencing","year":2009,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Carbonic anhydrase; Chemistry; Isozyme; Gene isoform; Bicarbonate; Biochemistry; Histidine; RNase P; Stereochemistry; Enzyme; Gene; RNA","score_opus":0.006086174829624667,"score_gpt":0.21451694823723905,"score_spread":0.20843077340761437,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2098139034","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92449766,0.013894356,0.012853469,0.0026015819,0.00090186327,0.00018332076,0.0026003143,0.0011144833,0.04135292],"genre_scores_gemma":[0.9605767,0.0027226186,0.0064589093,0.00070036855,0.00013602522,0.00009871312,0.008000054,0.00014602204,0.02116059],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999082,0.000006436468,0.0000034065265,0.000019611323,0.00004756491,0.000014693891],"domain_scores_gemma":[0.999943,0.000007962646,0.000008305133,0.0000026022988,0.000014113932,0.000024048617],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000099399054,0.00031238224,0.00032129715,0.00010799949,0.00029299327,0.0004957587,0.0005420499,0.00036029366,0.0032603366],"category_scores_gemma":[0.000269294,0.00013147874,0.00016343837,0.00016750334,0.00017064028,0.00014700572,0.00022620693,0.0007708916,0.0013430531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00093590375,0.00016428779,0.0030152467,0.00025383342,0.00006302201,0.002439697,0.00019872625,0.004482425,0.92309994,0.0060106413,0.02981858,0.029517638],"study_design_scores_gemma":[0.0011728135,0.00057974545,0.032830883,0.00015669863,0.0001632757,0.004263268,0.00045776172,0.10287775,0.49174574,0.0052669067,0.3603601,0.00012500398],"about_ca_topic_score_codex":0.0041717594,"about_ca_topic_score_gemma":0.0034835897,"teacher_disagreement_score":0.0041717594,"about_ca_system_score_codex":0.0007749323,"about_ca_system_score_gemma":0.00051331904,"threshold_uncertainty_score":0.010906935},"labels":[],"label_agreement":null},{"id":"W2101908524","doi":"10.1158/0008-5472.can-10-4261","title":"Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":756,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto General Hospital; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Metastasis; Cancer research; Breast cancer; Tumor hypoxia; Metastatic breast cancer; Mammary tumor; Primary tumor; Cancer; Biology; Medicine; Pathology; Internal medicine; Radiation therapy","score_opus":0.0329006188135935,"score_gpt":0.3005830990729407,"score_spread":0.26768248025934716,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2101908524","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97278196,0.01152893,0.0079780845,0.0004594399,0.00007548266,0.00017934732,0.00074802357,0.0002799113,0.00596885],"genre_scores_gemma":[0.9841652,0.005691835,0.0037732262,0.00007408167,0.000019950754,0.00012057827,0.0006535175,0.000021037176,0.0054805484],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999578,0.0000055057753,0.0000024978813,0.000008878921,0.000013731904,0.00001155953],"domain_scores_gemma":[0.99997866,0.0000023543585,0.0000071806444,0.0000014767508,0.000003918544,0.0000064115266],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007714589,0.00032760616,0.0001782606,0.00013672023,0.00008407554,0.00014392572,0.00018299838,0.00014710527,0.0006602237],"category_scores_gemma":[0.000051536488,0.00006627524,0.00012562204,0.000101400896,0.0000993331,0.00010866135,0.00008729605,0.00036475138,0.00015346066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011710114,0.000049313436,0.0000753556,0.000060070135,0.0000061451124,0.000026243173,0.000005726291,0.00015062994,0.9948612,0.00011928568,0.00016633827,0.0043626046],"study_design_scores_gemma":[0.00006798951,0.000521539,0.0020246927,0.0000050472268,0.000014140968,0.00021380316,0.000006157416,0.0013065742,0.9898844,0.000029497955,0.0059222896,0.000003834641],"about_ca_topic_score_codex":0.0012875096,"about_ca_topic_score_gemma":0.003926408,"teacher_disagreement_score":0.0012875096,"about_ca_system_score_codex":0.00041586012,"about_ca_system_score_gemma":0.00023512148,"threshold_uncertainty_score":0.0030173063},"labels":[],"label_agreement":null},{"id":"W2102429484","doi":"10.1086/322157","title":"Extracellular Carbonic Anhydrase in the Dogfish,<i>Squalus acanthias</i>: A Role in CO<sub>2</sub>Excretion","year":2001,"lang":"en","type":"article","venue":"Physiological and Biochemical Zoology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bamfield Marine Sciences Centre","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Squalus acanthias; Carbonic anhydrase; Extracellular; Acetazolamide; Excretion; Gill; Spiny dogfish; Biochemistry; Biology; Chemistry; Internal medicine; Enzyme","score_opus":0.011146174636476432,"score_gpt":0.2299083792002799,"score_spread":0.21876220456380346,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102429484","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9978096,0.0010063981,0.0003963325,0.00005114736,0.0000052215546,0.000007889262,0.00017121741,0.000017662675,0.00053452834],"genre_scores_gemma":[0.9973929,0.0004939875,0.0006759012,0.000034955894,0.000004878986,0.000011488391,0.00031748897,0.0000060344273,0.0010623606],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999548,0.0000024502172,0.000004504671,0.000020018746,0.00001094976,0.0000071752365],"domain_scores_gemma":[0.9999236,0.0000052735063,0.00002709361,0.000005914795,0.000016458654,0.000021714093],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004853809,0.00026000268,0.000218972,0.00016300833,0.00017466987,0.00025031727,0.0001447315,0.00030427138,0.0004377563],"category_scores_gemma":[0.00010615358,0.00015390615,0.0001690156,0.000090117486,0.00026973826,0.00024333005,0.00019965258,0.00021271,0.000112180074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012246102,0.0000037449527,0.0041847653,0.00005317748,0.0000066746743,0.00005431362,0.000032402186,0.00002290767,0.9944541,0.000024682935,0.000016103255,0.0010247515],"study_design_scores_gemma":[0.0000662249,0.00088922464,0.50442314,0.00001584893,0.00008697979,0.0013296262,0.00038265742,0.0010423822,0.487363,0.00016232337,0.0042207283,0.000017758492],"about_ca_topic_score_codex":0.0066494453,"about_ca_topic_score_gemma":0.009992176,"teacher_disagreement_score":0.0066494453,"about_ca_system_score_codex":0.0004487898,"about_ca_system_score_gemma":0.000262999,"threshold_uncertainty_score":0.013221443},"labels":[],"label_agreement":null},{"id":"W2105095944","doi":"10.3109/10731199.2011.581052","title":"Polyhemoglobin-superoxide Dismutase-catalase-carbonic Anhydrase: A Novel Biotechnology-based Blood Substitute that Transports both Oxygen and Carbon Dioxide and also Acts as an Antioxidant","year":2011,"lang":"en","type":"article","venue":"Artificial Cells Blood Substitutes and Biotechnology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Carbonic anhydrase; Catalase; Superoxide dismutase; Antioxidant; Chemistry; Carbon dioxide; Oxygen; Biochemistry; Reactive oxygen species; Dismutase; Enzyme; Organic chemistry","score_opus":0.016266054285304827,"score_gpt":0.2050250588404421,"score_spread":0.18875900455513725,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2105095944","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9216256,0.005911005,0.06853714,0.00043903387,0.000106227155,0.00013122118,0.00023521022,0.0002807612,0.0027337046],"genre_scores_gemma":[0.9540251,0.0020069226,0.038604733,0.000074850504,0.00002585442,0.000071241004,0.00041519196,0.000059138365,0.0047170497],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987614,0.000016811293,0.000010086597,0.000027200644,0.00005936415,0.000010310838],"domain_scores_gemma":[0.99990785,0.000010706689,0.000039242892,0.000007493988,0.000014805939,0.000019903135],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015792294,0.00034527804,0.00015583874,0.00016184151,0.00009160356,0.00022750515,0.00024716335,0.00026133878,0.0003448731],"category_scores_gemma":[0.00012558431,0.00011198362,0.00013726797,0.00017701702,0.00018807249,0.00021320343,0.00012471317,0.00034820038,0.00019847428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000017827002,0.000023817249,0.000119076256,0.000027858146,0.0000024022404,0.0000142545305,0.0000038852304,0.00007310716,0.99785197,0.00012360522,0.000036359037,0.0017059149],"study_design_scores_gemma":[0.000004691982,0.0000708478,0.00036865182,0.0000013266452,0.000005839294,0.00012427538,0.000001518871,0.00046692774,0.99644804,0.000013893547,0.0024923268,0.0000017040051],"about_ca_topic_score_codex":0.0003519229,"about_ca_topic_score_gemma":0.0006788889,"teacher_disagreement_score":0.0003519229,"about_ca_system_score_codex":0.00033068322,"about_ca_system_score_gemma":0.00025819935,"threshold_uncertainty_score":0.0023993254},"labels":[],"label_agreement":null},{"id":"W2117803125","doi":"10.3892/or.2015.4184","title":"Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation","year":2015,"lang":"en","type":"article","venue":"Oncology Reports","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Juravinski Cancer Centre; McMaster University","funders":"McMaster University","keywords":"Radioresistance; Cancer research; In vivo; Small hairpin RNA; Chemistry; Oncogene; Cell; Cell culture; Biology; Molecular biology; Cell cycle; Gene knockdown; Apoptosis; Biochemistry","score_opus":0.016006628411380716,"score_gpt":0.25682965880547404,"score_spread":0.2408230303940933,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2117803125","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9928377,0.0022638948,0.0015969322,0.00013067303,0.000086758766,0.00006634039,0.00035183676,0.00013200044,0.0025338794],"genre_scores_gemma":[0.9924056,0.0018369205,0.0015817849,0.00005411476,0.000014798019,0.00005713336,0.0005300919,0.000013661727,0.0035059412],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985206,0.00001682189,0.000015993099,0.000028234947,0.000045740464,0.000041171068],"domain_scores_gemma":[0.9999391,0.000011367543,0.000015130374,0.0000091826205,0.0000079875,0.000017219154],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117824675,0.0002903767,0.0004213465,0.00017895509,0.00011841882,0.00021029153,0.00021805779,0.00022385518,0.0012725191],"category_scores_gemma":[0.00009023297,0.00013916366,0.0002751314,0.00014879393,0.00017864958,0.0001335478,0.00013508536,0.0006405447,0.00029247664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010719936,0.000063234416,0.00017680491,0.000036995454,0.000009372158,0.00002513282,0.000010458161,0.000059649275,0.9985318,0.00004346191,0.00006538283,0.00087046146],"study_design_scores_gemma":[0.000019375393,0.00076439383,0.0041406015,0.0000043565437,0.000018128667,0.000120032084,0.000020623265,0.0006879702,0.9922809,0.00002089819,0.0019192811,0.0000034136058],"about_ca_topic_score_codex":0.0012306478,"about_ca_topic_score_gemma":0.002197206,"teacher_disagreement_score":0.0012725191,"about_ca_system_score_codex":0.00023553905,"about_ca_system_score_gemma":0.00025555625,"threshold_uncertainty_score":0.0042570233},"labels":[],"label_agreement":null},{"id":"W2123644397","doi":"10.1074/jbc.m407184200","title":"Crystal Structure and Mutagenesis of a Protein Phosphatase-1:Calcineurin Hybrid Elucidate the Role of the β12-β13 Loop in Inhibitor Binding","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Pfizer","keywords":"Calcineurin; Phosphatase; Loop (graph theory); Mutagenesis; Chemistry; Cell biology; Mutation; Molecular biology; Biology; Biochemistry; Phosphorylation; Gene; Internal medicine; Medicine","score_opus":0.006735605791144374,"score_gpt":0.20752624085778298,"score_spread":0.2007906350666386,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2123644397","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9970516,0.0005740152,0.0011212545,0.00009662988,0.000015212638,0.0000179596,0.0002097988,0.000030353329,0.00088315114],"genre_scores_gemma":[0.9933995,0.00054580194,0.003259125,0.00006499754,0.0000054912616,0.000020098561,0.00092685776,0.000018362163,0.0017597739],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992025,0.000009765795,0.000004103082,0.00001825883,0.00003462486,0.000013122777],"domain_scores_gemma":[0.999933,0.00001619457,0.0000160635,0.0000027539318,0.000010308631,0.000021734932],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116301206,0.0002593127,0.0002481669,0.000091939255,0.00020703548,0.00026281,0.00041425033,0.00034976305,0.00072484615],"category_scores_gemma":[0.00012170784,0.00011544413,0.00017418472,0.00020832002,0.00016999783,0.00010542224,0.0001437274,0.0009986302,0.00015809214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002461006,0.00012140229,0.0009280652,0.00005486065,0.000020939628,0.00027873664,0.000075327785,0.0012041761,0.99494934,0.00050250295,0.00014603217,0.0014725043],"study_design_scores_gemma":[0.00015068836,0.0003041693,0.01813136,0.000028195618,0.00008233459,0.0010451205,0.00016896088,0.0225207,0.950426,0.00029390707,0.006817821,0.00003067197],"about_ca_topic_score_codex":0.0042039063,"about_ca_topic_score_gemma":0.004934884,"teacher_disagreement_score":0.0042039063,"about_ca_system_score_codex":0.00075966766,"about_ca_system_score_gemma":0.00036331272,"threshold_uncertainty_score":0.008358896},"labels":[],"label_agreement":null},{"id":"W2124261227","doi":"10.1369/jhc.4a6575.2005","title":"Region- and Cell-specific Differences in the Distribution of Carbonic Anhydrases II, III, XII, and XIV in the Adult Rat Epididymis","year":2005,"lang":"en","type":"article","venue":"Journal of Histochemistry & Cytochemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; McGill University","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Epididymis; Cytosol; Carbonic anhydrase; Immunocytochemistry; Basal (medicine); Gene isoform; Biology; Staining; Carbonic anhydrase II; Molecular biology; Lumen (anatomy); Chemistry; Cell biology; Endocrinology; Biochemistry; Enzyme; Gene","score_opus":0.008679338038625523,"score_gpt":0.2073633923520624,"score_spread":0.19868405431343686,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2124261227","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993587,0.0017467835,0.0026937174,0.000030163366,0.000010225035,0.000015800488,0.00034716298,0.000047683636,0.0015215266],"genre_scores_gemma":[0.9884807,0.0014549524,0.003653404,0.00003543801,0.00001390292,0.000048018326,0.0007861978,0.00003008124,0.005497328],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999132,0.000004699708,0.0000074553777,0.000036281337,0.000016545813,0.000021727374],"domain_scores_gemma":[0.99988866,0.000014562581,0.00003055333,0.000011583715,0.000024942274,0.000029814495],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111740315,0.00019191617,0.00019985181,0.00026174574,0.00011119951,0.00025314695,0.00017202464,0.00014347325,0.0010172151],"category_scores_gemma":[0.000093676994,0.00022383235,0.0001882878,0.00010609965,0.00018641747,0.00021428805,0.00015030132,0.0002637448,0.0003409261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00004267455,0.0000030172073,0.0007847794,0.000017079175,0.0000029006046,0.000034904635,0.000016572469,0.000009367134,0.998461,0.00005176351,0.0000062184467,0.0005697474],"study_design_scores_gemma":[0.000022172999,0.0003925995,0.17846331,0.0000121438,0.000048956368,0.00067283306,0.00015926649,0.00038999366,0.81766623,0.000109533365,0.0020515015,0.00001150251],"about_ca_topic_score_codex":0.0013150665,"about_ca_topic_score_gemma":0.0027460416,"teacher_disagreement_score":0.0013150665,"about_ca_system_score_codex":0.00018072748,"about_ca_system_score_gemma":0.00020661527,"threshold_uncertainty_score":0.0034028888},"labels":[],"label_agreement":null},{"id":"W2125640504","doi":"10.1152/ajpregu.00477.2006","title":"Type IV carbonic anhydrase is present in the gills of spiny dogfish (<i>Squalus acanthias</i>)","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Genomics; University of Ottawa","funders":"","keywords":"Squalus acanthias; Spiny dogfish; Carbonic anhydrase; Gill; Biology; Anatomy; Chemistry; Fishery; Zoology; Endocrinology; Biochemistry; Fish <Actinopterygii>; Enzyme","score_opus":0.013808327171792836,"score_gpt":0.2716343085818368,"score_spread":0.257825981410044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2125640504","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99902296,0.0002487247,0.00031377075,0.000013733112,0.000003405462,0.0000038733506,0.0001460442,0.00002054734,0.00022691372],"genre_scores_gemma":[0.9962979,0.00026677037,0.0013257455,0.00003887748,0.0000063836637,0.000011840012,0.0008966893,0.000008721207,0.0011470998],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999293,0.000002004172,0.000006279919,0.000036071124,0.000015858155,0.000010405469],"domain_scores_gemma":[0.9997968,0.000012950878,0.00009171263,0.000012871373,0.000032765613,0.000052903084],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000052150568,0.00021647573,0.00021580327,0.0003521308,0.00016914605,0.0002759797,0.00015512267,0.0002427431,0.0007245613],"category_scores_gemma":[0.00018973839,0.00019330587,0.00019518127,0.00019818306,0.00027280513,0.00025419443,0.00022571142,0.00016791832,0.00025049274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008618847,0.0000067989886,0.028528258,0.00007013611,0.000019076548,0.0001650885,0.00009833274,0.000027763095,0.96870965,0.000034099758,0.000044513465,0.0022102145],"study_design_scores_gemma":[0.00002008656,0.00050443393,0.9224008,0.000012357011,0.00006694339,0.0019142099,0.00044948878,0.00042208654,0.07168359,0.00009878224,0.002410607,0.000016568323],"about_ca_topic_score_codex":0.003570404,"about_ca_topic_score_gemma":0.0046668723,"teacher_disagreement_score":0.003570404,"about_ca_system_score_codex":0.00031359014,"about_ca_system_score_gemma":0.00021542893,"threshold_uncertainty_score":0.007099271},"labels":[],"label_agreement":null},{"id":"W2129345554","doi":"10.18632/oncotarget.2860","title":"The Na+ /H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells","year":2014,"lang":"en","type":"article","venue":"Oncotarget","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"University of Alberta","funders":"Cure Brain Cancer Foundation; Breast Cancer Society of Canada; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Triple-negative breast cancer; Breast cancer; Metastasis; Cancer research; Paclitaxel; Medicine; Cancer; Metastatic breast cancer; Internal medicine; Chemotherapy; Oncology","score_opus":0.01041419316670791,"score_gpt":0.2668425040828913,"score_spread":0.2564283109161834,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2129345554","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99157166,0.004654448,0.0017601101,0.00025643822,0.000054043303,0.000061656676,0.00017385004,0.000041218882,0.0014265775],"genre_scores_gemma":[0.99147195,0.0035165444,0.002267788,0.00007759436,0.000011709647,0.000042588694,0.00028025112,0.000010739126,0.002320923],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994075,0.0000067378774,0.0000047991834,0.000010380749,0.000024503288,0.000012797603],"domain_scores_gemma":[0.99997056,0.0000051087877,0.000008418028,0.000002708141,0.0000063619686,0.000006870392],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011869772,0.0001876077,0.0003995769,0.00010605595,0.00012509715,0.0002625936,0.00017622298,0.00020703589,0.0005842029],"category_scores_gemma":[0.000046862657,0.00009534079,0.00019106387,0.00013704837,0.00009782933,0.00016322329,0.000120382116,0.00039472894,0.00018196243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016671563,0.0000586686,0.00031295512,0.000058102938,0.0000063586663,0.00004316934,0.000012699826,0.00012453673,0.99586654,0.00005699467,0.000080046746,0.0032133076],"study_design_scores_gemma":[0.000052594736,0.00083033997,0.0031958465,0.000009313672,0.000048107126,0.00034936934,0.000030660864,0.0011875296,0.98969215,0.000021122178,0.004578153,0.000004706572],"about_ca_topic_score_codex":0.00041922551,"about_ca_topic_score_gemma":0.001425167,"teacher_disagreement_score":0.0005842029,"about_ca_system_score_codex":0.00025790656,"about_ca_system_score_gemma":0.00019225225,"threshold_uncertainty_score":0.0019543767},"labels":[],"label_agreement":null},{"id":"W2131508727","doi":"10.2967/jnumed.114.153288","title":"Trimeric Radiofluorinated Sulfonamide Derivatives to Achieve In Vivo Selectivity for Carbonic Anhydrase IX–Targeted PET Imaging","year":2015,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Biodistribution; Chemistry; Carbonic anhydrase; In vivo; Acetazolamide; Sulfonamide; Enzyme; Specific activity; Azide; Radiochemistry; Stereochemistry; In vitro; Biochemistry; Organic chemistry","score_opus":0.015039724276818418,"score_gpt":0.2737005455811183,"score_spread":0.25866082130429985,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2131508727","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98695135,0.0011294782,0.009616331,0.00010509969,0.000022997921,0.000083876155,0.00015171696,0.000114165385,0.0018249172],"genre_scores_gemma":[0.986746,0.00063757086,0.009791309,0.000067911955,0.000013491159,0.00007148784,0.00025832496,0.000027386859,0.0023864273],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988925,0.00002360642,0.000008163577,0.000023208697,0.000028042006,0.000027804657],"domain_scores_gemma":[0.99987626,0.000019741974,0.0000416007,0.000013083888,0.000027061986,0.000022209033],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026297543,0.00046324695,0.00018411467,0.00012277861,0.00008627714,0.00017518025,0.0003559028,0.00041561617,0.0010881552],"category_scores_gemma":[0.00019361392,0.00011992839,0.00018477031,0.00010663458,0.00018135963,0.00018221783,0.00012368143,0.00041570733,0.00038694128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005303088,0.000011809801,0.00007576824,0.000021809956,0.000005113344,0.000026461848,0.000009013198,0.00013663682,0.9988009,0.000071658666,0.00003433502,0.00075355446],"study_design_scores_gemma":[0.000016620208,0.00022906059,0.00052038557,0.0000021293024,0.000010233029,0.00012806001,0.0000046295477,0.000937126,0.9963496,0.000013628348,0.0017850084,0.0000034611999],"about_ca_topic_score_codex":0.00089731073,"about_ca_topic_score_gemma":0.0011808139,"teacher_disagreement_score":0.0010881552,"about_ca_system_score_codex":0.0004969394,"about_ca_system_score_gemma":0.0001874023,"threshold_uncertainty_score":0.0036401749},"labels":[],"label_agreement":null},{"id":"W2131695984","doi":"10.1152/ajpcell.00157.2007","title":"Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Carbonic anhydrase; Bicarbonate; Transmembrane protein; Chemistry; Transporter; Secretion; Extracellular; Biochemistry; Carbonic anhydrase II; Cell biology; Transport protein; Transmembrane domain; Carbonic anhydrase inhibitor; Sodium–hydrogen antiporter; Biophysics; Enzyme; Biology; Receptor; Sodium","score_opus":0.003812850869260137,"score_gpt":0.21652342094635552,"score_spread":0.21271057007709537,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2131695984","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9708703,0.020335073,0.004653433,0.00061780243,0.000081833154,0.000040436316,0.0002643426,0.00008399921,0.0030527925],"genre_scores_gemma":[0.987623,0.0059181517,0.002352292,0.000122656,0.00005529737,0.000029946932,0.0004573278,0.000013118053,0.0034282175],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997626,0.000046073506,0.00001605608,0.000051594663,0.00008049283,0.000043191627],"domain_scores_gemma":[0.99990237,0.000016429496,0.000021953083,0.0000071928444,0.000025992376,0.000026061378],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022422409,0.000319234,0.0003313898,0.00018039366,0.00030273924,0.0004958797,0.00022745656,0.00050662097,0.00077059714],"category_scores_gemma":[0.00034232673,0.0001631234,0.0002947106,0.00023418786,0.0001717208,0.00039959076,0.0003399262,0.00031057498,0.00027022784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012243126,0.000012866349,0.002290512,0.000103536506,0.00003168472,0.00022196115,0.000030499741,0.00013316634,0.994549,0.00035647696,0.00014518538,0.002002751],"study_design_scores_gemma":[0.000057353303,0.0003538986,0.083540365,0.000038904273,0.00008779161,0.0018174017,0.0001587737,0.009094633,0.88831574,0.00036568608,0.016149506,0.000019963429],"about_ca_topic_score_codex":0.001497456,"about_ca_topic_score_gemma":0.0018710757,"teacher_disagreement_score":0.001497456,"about_ca_system_score_codex":0.00069512613,"about_ca_system_score_gemma":0.00023740293,"threshold_uncertainty_score":0.0050435066},"labels":[],"label_agreement":null},{"id":"W2135279774","doi":"10.3389/fonc.2012.00199","title":"Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis","year":2013,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Institut National Du Cancer; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Radioresistance; Intracellular pH; Extracellular; Intracellular; Cancer research; Tumor microenvironment; Programmed cell death; Chemistry; Acidosis; Biology; Cell culture; Cell biology; Biochemistry; Apoptosis; Endocrinology","score_opus":0.004898266707432353,"score_gpt":0.20811708266391507,"score_spread":0.20321881595648272,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2135279774","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99539584,0.0011813871,0.0017517727,0.00008140415,0.0000280257,0.000036347523,0.00037563153,0.00007907067,0.001070467],"genre_scores_gemma":[0.99263483,0.0011476092,0.002166302,0.00003310122,0.000008511439,0.000052489366,0.0005061942,0.000023965422,0.0034269826],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999262,0.000007071099,0.000009021693,0.00001869012,0.000018700228,0.000020275476],"domain_scores_gemma":[0.9999479,0.000008784033,0.000017519153,0.0000065154118,0.000004855771,0.000014396162],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006630401,0.00026568814,0.00027553775,0.00010174959,0.00009182649,0.00021560153,0.00016272647,0.00017855267,0.0011675257],"category_scores_gemma":[0.000057716123,0.00012345366,0.00018326975,0.00010510094,0.00015115489,0.00010948353,0.0001396655,0.00034485583,0.00021796259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000055887725,0.00000852384,0.000059441136,0.000014089991,0.0000029921775,0.000013779212,0.000004084248,0.00003606635,0.99940705,0.000029051076,0.000016861612,0.0003521932],"study_design_scores_gemma":[0.000014966511,0.00020200494,0.0018735832,0.0000026244745,0.000012792748,0.000100167206,0.000013362391,0.00046960032,0.9955373,0.000013034765,0.0017583205,0.0000022910028],"about_ca_topic_score_codex":0.00088898325,"about_ca_topic_score_gemma":0.0013187006,"teacher_disagreement_score":0.0011675257,"about_ca_system_score_codex":0.00022282517,"about_ca_system_score_gemma":0.00021025122,"threshold_uncertainty_score":0.0039057732},"labels":[],"label_agreement":null},{"id":"W2141217856","doi":"10.1016/s0002-9440(10)64048-5","title":"Expression of the Hypoxia-Inducible and Tumor-Associated Carbonic Anhydrases in Ductal Carcinoma in Situ of the Breast","year":2001,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency; University of Manitoba","funders":"Medical Research and Materiel Command; Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Ductal carcinoma; Pathology; Immunohistochemistry; Calcification; Hypoxia (environmental); Necrosis; Extracellular; Carcinoma; Biology; Breast cancer; Cancer research; Medicine; Internal medicine; Cancer; Chemistry","score_opus":0.005453774152721143,"score_gpt":0.21099336913536892,"score_spread":0.2055395949826478,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2141217856","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99665725,0.0011073508,0.0006065795,0.00005441604,0.000011193791,0.000005518451,0.00015109731,0.000012711655,0.0013938618],"genre_scores_gemma":[0.9960504,0.00072956417,0.00038784943,0.000009913966,0.0000079753,0.000008807024,0.00027926156,0.00000541952,0.0025207824],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.99989593,0.000013209245,0.00001078249,0.00001572594,0.000031552358,0.000032809916],"domain_scores_gemma":[0.99985576,0.000037048994,0.000023834282,0.000013640746,0.000030167506,0.000039488354],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011276598,0.00012136052,0.00016421113,0.000263824,0.00015099139,0.00023145789,0.0001213765,0.00015153285,0.00094985083],"category_scores_gemma":[0.00025338386,0.00013494799,0.00009798039,0.0002148101,0.00015404871,0.00012014381,0.00011321516,0.00019217691,0.00018144007],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024804566,0.000016280927,0.0015987707,0.000022318574,0.0000063213583,0.00013099315,0.00004968351,0.000036706086,0.99631643,0.00024814974,0.00003757791,0.0012887573],"study_design_scores_gemma":[0.00004274833,0.00039331894,0.08785998,0.000008911263,0.000069061134,0.0030114548,0.00040308922,0.0015126079,0.8999509,0.00028638996,0.0064505474,0.000011008874],"about_ca_topic_score_codex":0.0018707722,"about_ca_topic_score_gemma":0.0018878641,"teacher_disagreement_score":0.0018707722,"about_ca_system_score_codex":0.00032172137,"about_ca_system_score_gemma":0.00022577663,"threshold_uncertainty_score":0.003719747},"labels":[],"label_agreement":null},{"id":"W2156169130","doi":"10.1107/s0907444900006545","title":"β-Carbonic anhydrase from<i>Pisum sativum</i>: crystallization and preliminary X-ray analysis","year":2000,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada Research Chairs; University of Toronto; Stem Cell Network; University of New Brunswick","funders":"","keywords":"Pisum; Orthorhombic crystal system; Crystallography; Histone octamer; Sativum; Molecule; Carbonic anhydrase; Crystallization; X-ray crystallography; Chemistry; Diffraction; Crystal structure; Biology; Physics; Enzyme; Biochemistry; Optics; Botany","score_opus":0.008474674174353087,"score_gpt":0.21154840174224057,"score_spread":0.2030737275678875,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2156169130","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9572625,0.0067858645,0.015694162,0.0009113826,0.00009252003,0.00063249125,0.010423802,0.0003656001,0.007831643],"genre_scores_gemma":[0.8793963,0.010416466,0.03735562,0.00034390847,0.0000668473,0.0004174933,0.0583486,0.00027465788,0.013380014],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997904,0.000027528418,0.000019919138,0.00003982971,0.00007563189,0.00004673141],"domain_scores_gemma":[0.9997974,0.00003406573,0.000018772631,0.000023936713,0.00007837408,0.000047375033],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039327482,0.0007021283,0.0006748469,0.0002799805,0.0004421818,0.00046819058,0.0006266306,0.00042549663,0.0013437164],"category_scores_gemma":[0.00047225578,0.00024975705,0.00032137526,0.0011811779,0.00023187161,0.00026249146,0.00018353012,0.0007524083,0.0009814552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000378109,0.00006998553,0.0009432796,0.00026308186,0.00003258536,0.00046739657,0.00017230558,0.0005844861,0.9906226,0.00023693261,0.0007337734,0.005495436],"study_design_scores_gemma":[0.0001423284,0.0003732653,0.031475317,0.000039159313,0.00008263963,0.0012613103,0.0002538774,0.002627462,0.9221053,0.00029710136,0.04130572,0.000036387264],"about_ca_topic_score_codex":0.007391324,"about_ca_topic_score_gemma":0.007166292,"teacher_disagreement_score":0.007391324,"about_ca_system_score_codex":0.0008033675,"about_ca_system_score_gemma":0.000478999,"threshold_uncertainty_score":0.014696598},"labels":[],"label_agreement":null},{"id":"W2163235349","doi":"10.1128/jb.186.3.623-630.2004","title":"A Novel Evolutionary Lineage of Carbonic Anhydrase (ε Class) Is a Component of the Carboxysome Shell","year":2004,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":279,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"RuBisCO; Biology; Carbon fixation; Autotroph; Cyanobacteria; Carbonic anhydrase; Ribulose; Biochemistry; Synechococcus; Photosynthesis; Prochlorococcus; Pyruvate carboxylase; Lineage (genetic); Bacteria; Botany; Enzyme; Genetics; Gene","score_opus":0.008914165335605097,"score_gpt":0.21893224226618457,"score_spread":0.21001807693057947,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2163235349","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9882464,0.0016749655,0.0058627445,0.00016863718,0.000030407615,0.000027384958,0.00042002567,0.00011143548,0.0034578764],"genre_scores_gemma":[0.983994,0.0010110093,0.0072868485,0.00012343483,0.000021546568,0.00001584686,0.0014384764,0.00003094656,0.0060777906],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993074,0.0000034751345,0.0000037295874,0.000032705495,0.000018131035,0.000011222055],"domain_scores_gemma":[0.9998449,0.000014963904,0.000050078008,0.000013732776,0.00003087318,0.000045435503],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008089957,0.00031709828,0.00017284247,0.000318766,0.00026133106,0.00040299702,0.00023685646,0.0003167931,0.0005533699],"category_scores_gemma":[0.00014539238,0.000093211595,0.00022643222,0.0003358078,0.00028439346,0.0002588138,0.0003722894,0.00046759448,0.00030901993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000082338214,0.000013924274,0.0100651635,0.000033787925,0.0000070795113,0.0002246347,0.00007272367,0.000052351228,0.9808297,0.0004868209,0.00007137259,0.008060109],"study_design_scores_gemma":[0.000022272337,0.00039942158,0.3954903,0.00005121009,0.00007291197,0.009209855,0.00034726254,0.0031151592,0.5343632,0.0011475922,0.055746477,0.00003430324],"about_ca_topic_score_codex":0.001496709,"about_ca_topic_score_gemma":0.0018160959,"teacher_disagreement_score":0.001496709,"about_ca_system_score_codex":0.00029711143,"about_ca_system_score_gemma":0.00037026816,"threshold_uncertainty_score":0.00297606},"labels":[],"label_agreement":null},{"id":"W2165253692","doi":"10.1002/jcc.20481","title":"Coupled atomic charge selectivity for optimal ligand‐charge distributions at protein binding sites","year":2006,"lang":"en","type":"article","venue":"Journal of Computational Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Biotechnology Research Institute; McGill University","funders":"","keywords":"Chemistry; Selectivity; Partial charge; Charge (physics); Ligand (biochemistry); Chemical physics; Binding energy; Atomic charge; Computational chemistry; Molecular dynamics; Molecule; Charge density; Atomic physics; Physics; Quantum mechanics; Catalysis","score_opus":0.007915144812363545,"score_gpt":0.23835678588202427,"score_spread":0.23044164106966072,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2165253692","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87471974,0.00048367752,0.12123788,0.000074200885,0.0000143047555,0.00007115877,0.00011317488,0.00024267568,0.0030431675],"genre_scores_gemma":[0.9834062,0.00022118786,0.015815713,0.00003135816,0.0000033330818,0.000046484358,0.00006632972,0.000024720359,0.0003847054],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9997726,0.000022591828,0.000010093944,0.000053791693,0.000109382425,0.000031454078],"domain_scores_gemma":[0.9997428,0.00010216136,0.00005439162,0.00003135251,0.000054355372,0.000014946659],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003661254,0.00030394376,0.00030162057,0.0004003692,0.00019896918,0.00042921913,0.0004284763,0.00027662827,0.0012298134],"category_scores_gemma":[0.00084447063,0.00018847927,0.00021392263,0.00032827116,0.00035498908,0.0005514845,0.00034662764,0.0003966582,0.00019162506],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038175972,0.00010069637,0.0043113697,0.00015341847,0.000040153882,0.000071016715,0.00007163585,0.06705762,0.8950581,0.006188998,0.0002388834,0.026326336],"study_design_scores_gemma":[0.000040207942,0.00026745762,0.0055685122,0.0000064117107,0.000033008455,0.000087744455,0.00005022778,0.41840604,0.5718982,0.002652935,0.0009639026,0.00002529502],"about_ca_topic_score_codex":0.0011343273,"about_ca_topic_score_gemma":0.0012078529,"teacher_disagreement_score":0.0012298134,"about_ca_system_score_codex":0.0006434758,"about_ca_system_score_gemma":0.00033958448,"threshold_uncertainty_score":0.004668772},"labels":[],"label_agreement":null},{"id":"W2168361625","doi":"10.1016/j.bmcl.2014.05.021","title":"Synthesis and evaluation of 18F-labeled tertiary benzenesulfonamides for imaging carbonic anhydrase IX expression in tumours with positron emission tomography","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Positron emission tomography; In vivo; Carbonic anhydrase; Ex vivo; Enzyme; In vitro; Biochemistry; Nuclear medicine; Medicine","score_opus":0.005377274377020196,"score_gpt":0.21970227822257513,"score_spread":0.21432500384555492,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2168361625","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9554589,0.005381007,0.029625483,0.0002921376,0.00008224873,0.00064215815,0.0009019169,0.00023682696,0.0073792953],"genre_scores_gemma":[0.97619903,0.0033662787,0.015069604,0.000076109,0.000023279103,0.00019405849,0.00093368423,0.00007011823,0.0040679127],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983215,0.000045615707,0.000013769188,0.000023629327,0.00003450213,0.00005034975],"domain_scores_gemma":[0.9998154,0.00002904621,0.00004447108,0.000023600938,0.000040223735,0.000047341833],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054970704,0.00049404346,0.00039991265,0.000256991,0.00022352012,0.00027269198,0.00051211874,0.00049104315,0.0012041384],"category_scores_gemma":[0.00038712737,0.0002613338,0.00027813012,0.00027984148,0.00022333054,0.00029529308,0.00019855058,0.00040435925,0.00054112606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048771908,0.00012049006,0.00020957581,0.00016956354,0.000026221483,0.00031128703,0.000111512054,0.0018586876,0.9877868,0.00081569306,0.0002778842,0.007824442],"study_design_scores_gemma":[0.00008519599,0.0010890034,0.0005864145,0.000008217034,0.000030505946,0.00025596545,0.000016714954,0.0011695239,0.9914743,0.00004491282,0.005226411,0.000012879438],"about_ca_topic_score_codex":0.0017917645,"about_ca_topic_score_gemma":0.0025512485,"teacher_disagreement_score":0.0017917645,"about_ca_system_score_codex":0.000751764,"about_ca_system_score_gemma":0.0005375625,"threshold_uncertainty_score":0.0054544806},"labels":[],"label_agreement":null},{"id":"W2171665032","doi":"10.1186/1471-2407-13-378","title":"Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines","year":2013,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Hospital for Sick Children; Cancer Research Society","keywords":"Chromogranin A; Cancer research; Matrigel; Medicine; Cell growth; Growth inhibition; Viability assay; Pathology; Chemistry; Internal medicine; Immunohistochemistry; In vitro; Angiogenesis; Biochemistry","score_opus":0.007110876920702449,"score_gpt":0.21909230997359683,"score_spread":0.21198143305289438,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2171665032","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99452883,0.00291195,0.0003569763,0.00009916192,0.000044866905,0.000026648275,0.00034677997,0.000058852773,0.0016259996],"genre_scores_gemma":[0.99597484,0.0016035356,0.00048821492,0.00003208587,0.000016524615,0.000029252684,0.00050864555,0.000006277961,0.0013406618],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999012,0.000014631895,0.0000104713645,0.000015700398,0.000033808203,0.000024181501],"domain_scores_gemma":[0.9999217,0.0000151295335,0.000018312463,0.000008620416,0.000009693239,0.000026573678],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008987487,0.00024087769,0.00026942417,0.000185505,0.00010628576,0.00014724687,0.00015828387,0.00017082228,0.0011105356],"category_scores_gemma":[0.00009119662,0.00007105991,0.00019563775,0.00012470021,0.00012883599,0.00010999618,0.00009753443,0.00033053066,0.00017735592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046265856,0.00015625951,0.00077740225,0.00009168537,0.000020741621,0.000083165876,0.000016795746,0.00013264621,0.9937265,0.00002893158,0.00024089115,0.0042622755],"study_design_scores_gemma":[0.00007343485,0.0035231472,0.013446735,0.000013444362,0.00005909255,0.00035657836,0.00005237657,0.0007808128,0.9781156,0.000016571785,0.003556022,0.000006110004],"about_ca_topic_score_codex":0.0012866742,"about_ca_topic_score_gemma":0.0034804675,"teacher_disagreement_score":0.0012866742,"about_ca_system_score_codex":0.00015115042,"about_ca_system_score_gemma":0.0002632732,"threshold_uncertainty_score":0.003715098},"labels":[],"label_agreement":null},{"id":"W2185273703","doi":"10.1091/mbc.e14-10-1484","title":"Forty-five years of cell-cycle genetics","year":2015,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Eurostars; National Cancer Institute","keywords":"Biology; Path (computing); Genetics; Cell cycle; Set (abstract data type); Evolutionary biology; Genealogy; Gene; History; Computer science","score_opus":0.008058476501755884,"score_gpt":0.2304970496200052,"score_spread":0.2224385731182493,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2185273703","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.048507858,0.43209672,0.089894556,0.1400005,0.03793734,0.00016700446,0.0010674711,0.000962265,0.24936636],"genre_scores_gemma":[0.37025133,0.3313536,0.052883558,0.030655831,0.009239881,0.00037587335,0.0015525159,0.00077331834,0.20291412],"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","domain_scores_codex":[0.99912244,0.0002872237,0.000049112597,0.00019300947,0.00024161943,0.00010661049],"domain_scores_gemma":[0.99827087,0.000815066,0.000105302934,0.0002136426,0.00029399572,0.0003011238],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0026510744,0.00051850337,0.00055216067,0.0013653524,0.0014625354,0.002217548,0.0006540137,0.0010537308,0.004679561],"category_scores_gemma":[0.003286758,0.00028088875,0.0004252422,0.0011014674,0.0057471995,0.001958683,0.0018651792,0.002993687,0.0018037457],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002935542,0.00014692954,0.002997723,0.00042703393,0.00005279198,0.00044791392,0.0032061774,0.0013906029,0.008732711,0.6230706,0.077605926,0.2816281],"study_design_scores_gemma":[0.000013066659,0.000057376797,0.0007436409,0.00017586879,0.000012021945,0.00019053798,0.00023208237,0.00015091234,0.0027039333,0.04708036,0.9486108,0.00002946853],"about_ca_topic_score_codex":0.0028534594,"about_ca_topic_score_gemma":0.0030973419,"teacher_disagreement_score":0.004679561,"about_ca_system_score_codex":0.0031923132,"about_ca_system_score_gemma":0.0020712446,"threshold_uncertainty_score":0.023162007},"labels":[],"label_agreement":null},{"id":"W2188767859","doi":"","title":"Antiproliferative effects of a series of novel synthetic sulfonate esters on human breast cancer cell line MCF-7.","year":2007,"lang":"en","type":"article","venue":"PubMed","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Moncton","funders":"","keywords":"MCF-7; Cancer cell; Apoptosis; Chemistry; Cell culture; Cancer research; Cancer; Breast cancer; Human breast; IC50; Growth inhibition; Cell growth; In vitro; Cell cycle; Cell cycle checkpoint; Pharmacology; Biochemistry; Internal medicine; Medicine; Biology","score_opus":0.013613515993541691,"score_gpt":0.2403728166740078,"score_spread":0.22675930068046612,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2188767859","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98861444,0.007987495,0.0007681327,0.00007551238,0.000026718191,0.000054069755,0.00051662803,0.000038960625,0.0019179918],"genre_scores_gemma":[0.98704755,0.008272407,0.0021515316,0.000051834086,0.000022594697,0.000044246877,0.0009074416,0.000009799141,0.0014927484],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999434,0.000014245432,0.000007851979,0.000007150679,0.00001767747,0.000009708835],"domain_scores_gemma":[0.9999496,0.000008938539,0.000019102941,0.0000032515022,0.000009946911,0.00000921973],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008714934,0.00041458284,0.00018358666,0.00025771878,0.000082599254,0.00012094429,0.0001445373,0.00018611747,0.0010924981],"category_scores_gemma":[0.000097118835,0.00007408952,0.00016195915,0.00021246354,0.00012262768,0.00012979188,0.00009871113,0.00016159663,0.00021423657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027242236,0.00007568979,0.00040262027,0.0002576042,0.0000142047475,0.000116707924,0.000018051707,0.00037101356,0.99149305,0.00006175948,0.0000709934,0.006845915],"study_design_scores_gemma":[0.0000335075,0.0032921673,0.0028114894,0.000022240829,0.000050068167,0.00048495832,0.000042183383,0.00035631118,0.9885988,0.000023418344,0.0042780205,0.0000068578574],"about_ca_topic_score_codex":0.00035334882,"about_ca_topic_score_gemma":0.0010123565,"teacher_disagreement_score":0.0010924981,"about_ca_system_score_codex":0.000116014,"about_ca_system_score_gemma":0.00017408626,"threshold_uncertainty_score":0.003654778},"labels":[],"label_agreement":null},{"id":"W2244053386","doi":"10.1139/w00-090","title":"Purification of the NADP<sup>+</sup>: F<sub>420</sub>oxidoreductase of<i>Methanosphaera stadtmanae</i>","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Oxidoreductase; NAD+ kinase; Enzyme; Chemistry; Cofactor; Reductase; Stereochemistry; Biochemistry","score_opus":0.005594838835485357,"score_gpt":0.18650165288206985,"score_spread":0.18090681404658449,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2244053386","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98089945,0.003588451,0.010031566,0.00031635052,0.00006632224,0.00012359412,0.002627085,0.0001594556,0.002187862],"genre_scores_gemma":[0.93356115,0.0040340237,0.027863808,0.00022904496,0.000039044193,0.00008643255,0.02359897,0.00009108712,0.010496453],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989927,0.00001225972,0.000011543739,0.000023045606,0.00003255032,0.000021270733],"domain_scores_gemma":[0.9998901,0.000015043393,0.00002106837,0.00001211233,0.000040963765,0.000020660751],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018173821,0.00062387745,0.00033316156,0.00023272542,0.000118288706,0.0002646917,0.00021887368,0.00022511736,0.00039217446],"category_scores_gemma":[0.0002509869,0.00014593784,0.00036061497,0.00044802192,0.00012203813,0.00017652602,0.00017742002,0.00041642817,0.00046085537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000053467928,0.000030269593,0.0008788833,0.000086164786,0.000009109146,0.000071378905,0.00004463503,0.00006443298,0.9931364,0.000082637205,0.00010927874,0.005433239],"study_design_scores_gemma":[0.000026227246,0.00036818182,0.031551827,0.00002983682,0.00006622088,0.0008895626,0.0001308559,0.0011508156,0.94447607,0.00018936295,0.021103198,0.000017925388],"about_ca_topic_score_codex":0.0030677682,"about_ca_topic_score_gemma":0.002009314,"teacher_disagreement_score":0.0030677682,"about_ca_system_score_codex":0.00030512369,"about_ca_system_score_gemma":0.0003615406,"threshold_uncertainty_score":0.00609982},"labels":[],"label_agreement":null},{"id":"W2252798168","doi":"10.1021/acs.molpharmaceut.5b00934","title":"PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with <sup>68</sup>Ga-Labeled Benzenesulfonamides","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Leading Edge Endowment Fund","keywords":"Biodistribution; Chemistry; In vivo; Acetazolamide; Monomer; Spect imaging; Carbonic anhydrase; Cancer research; Trimer; Enzyme; Dimer; Biochemistry; Molecular biology; Nuclear medicine; Medicine; In vitro; Biology; Internal medicine","score_opus":0.0089272496118337,"score_gpt":0.2567134719467655,"score_spread":0.24778622233493183,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2252798168","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98978615,0.001264006,0.006356449,0.000103802595,0.00001285442,0.000053936063,0.00028792946,0.0001434692,0.0019915137],"genre_scores_gemma":[0.9825472,0.0015080988,0.0117127085,0.0000667736,0.000011146725,0.00007844657,0.0004434874,0.000044077664,0.0035880539],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999553,0.00000785041,0.0000020715618,0.000011710671,0.000010602537,0.000012471272],"domain_scores_gemma":[0.99996054,0.000007750154,0.000011460944,0.0000036865486,0.0000065918184,0.000009968064],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116411604,0.00031469765,0.00024095396,0.000110462766,0.00006369203,0.00016520763,0.00018614694,0.00030796407,0.0005321819],"category_scores_gemma":[0.00007793507,0.00016398987,0.0001388408,0.00010750199,0.00016341734,0.00013042921,0.00008424737,0.00031312348,0.00017920643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009759518,0.000009469434,0.00009165167,0.000012987101,0.0000028271413,0.00003145912,0.0000044581725,0.00011521257,0.99917704,0.000025812076,0.00002093474,0.00041046884],"study_design_scores_gemma":[0.000014773739,0.00041504073,0.0020443697,0.0000025875597,0.000016563437,0.00021184103,0.0000082477745,0.0022552714,0.9941544,0.000011589883,0.000862101,0.000003191342],"about_ca_topic_score_codex":0.001977694,"about_ca_topic_score_gemma":0.0020911628,"teacher_disagreement_score":0.001977694,"about_ca_system_score_codex":0.0003578221,"about_ca_system_score_gemma":0.00020113165,"threshold_uncertainty_score":0.003932357},"labels":[],"label_agreement":null},{"id":"W2260418106","doi":"","title":"Synthesis and evaluation of monomeric, dimeric and trimeric benzenesulfonamide derivatives for imaging carbonic anhydrase IX with PET","year":2014,"lang":"en","type":"article","venue":"","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Chemistry; Carbonic anhydrase; Monomer; Stereochemistry; Combinatorial chemistry; Biochemistry; Enzyme; Organic chemistry","score_opus":0.009911125090848417,"score_gpt":0.2439509075880559,"score_spread":0.2340397824972075,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2260418106","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9753566,0.002785256,0.017978214,0.00016431136,0.00003233104,0.00024577018,0.00042245645,0.00012258634,0.0028924951],"genre_scores_gemma":[0.97187364,0.0019228208,0.020920178,0.00005331169,0.000010444698,0.00010937993,0.0005522361,0.000042477284,0.004515459],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998405,0.000037083428,0.000014541466,0.00002779063,0.000052132586,0.000027933156],"domain_scores_gemma":[0.9998485,0.000020256506,0.00004072252,0.00002080468,0.000036962683,0.000032723896],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000499318,0.00036049675,0.00025432874,0.0001519003,0.00014569855,0.00028755367,0.0003966223,0.00042709085,0.00080379477],"category_scores_gemma":[0.0003439109,0.00024584203,0.00019183858,0.00022628307,0.00018410044,0.0002547933,0.00013789584,0.0003867847,0.00029083304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006896484,0.000023157389,0.000051364175,0.000044128905,0.0000069403827,0.000042430827,0.000025734002,0.00039363338,0.9975304,0.00014713424,0.00005366072,0.0016124098],"study_design_scores_gemma":[0.000014799139,0.00023716365,0.00024193124,0.0000023361126,0.000010716295,0.00009208826,0.000008272995,0.00077997707,0.99669975,0.000011618837,0.0018967927,0.000004544303],"about_ca_topic_score_codex":0.0011761828,"about_ca_topic_score_gemma":0.0017919734,"teacher_disagreement_score":0.0011761828,"about_ca_system_score_codex":0.0005919272,"about_ca_system_score_gemma":0.0002361518,"threshold_uncertainty_score":0.0042948127},"labels":[],"label_agreement":null},{"id":"W2260727443","doi":"10.1007/s12039-015-1004-x","title":"Synthesis and antibacterial activity of new chiral N-sulfamoyloxazolidin-2-ones","year":2015,"lang":"en","type":"article","venue":"Journal of Chemical Sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Direction Générale de la Recherche Scientifique et du Développement Technologique; Research Nova Scotia","keywords":"Antibacterial activity; Escherichia coli; Bacteria; Chemistry; Staphylococcus aureus; Pseudomonas aeruginosa; Acinetobacter baumannii; Isocyanate; Klebsiella; Acinetobacter; Salmonella; Enterococcus; Gram; Microbiology; Organic chemistry; Biology; Biochemistry","score_opus":0.03109594395706955,"score_gpt":0.27409788291125803,"score_spread":0.24300193895418848,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2260727443","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96794254,0.009048876,0.0073412443,0.00032231808,0.0002875998,0.00012275067,0.00041709308,0.00015194765,0.01436573],"genre_scores_gemma":[0.981267,0.004775804,0.0057434235,0.00013597813,0.000066471606,0.00008198751,0.00029404822,0.000018098026,0.00761728],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999168,0.000013699935,0.000010724956,0.000010531688,0.000017241875,0.000030994644],"domain_scores_gemma":[0.9999374,0.00000777484,0.00001678253,0.0000050071963,0.00001091758,0.000022080738],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016502028,0.00045752435,0.00024454226,0.00026068033,0.00016885775,0.00022822013,0.0003408575,0.0002190123,0.0014100012],"category_scores_gemma":[0.00013145166,0.00014861753,0.00019241711,0.00016743451,0.00017869676,0.00021793264,0.00023258437,0.00034274554,0.0003716013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004979513,0.00014521784,0.00030143687,0.0004669213,0.000016697495,0.00061842037,0.000111870184,0.0011372344,0.9725795,0.0026505596,0.00067208457,0.020802109],"study_design_scores_gemma":[0.00019258805,0.002164601,0.0019692674,0.00003582711,0.000037524223,0.00046214144,0.000056294662,0.002093708,0.97293705,0.00037777744,0.01963663,0.00003654245],"about_ca_topic_score_codex":0.0004904056,"about_ca_topic_score_gemma":0.0009886256,"teacher_disagreement_score":0.0014100012,"about_ca_system_score_codex":0.00027789423,"about_ca_system_score_gemma":0.00043471358,"threshold_uncertainty_score":0.004716933},"labels":[],"label_agreement":null},{"id":"W2324644336","doi":"10.3184/146867816x14446664644428","title":"Effect of buffer on fumarase reactions","year":2016,"lang":"en","type":"article","venue":"Progress in Reaction Kinetics and Mechanism","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Isomerization; Fumarase; Buffer (optical fiber); Mechanism (biology); Catalysis; Reaction mechanism; Buffer solution; Photochemistry; Stereochemistry; Enzyme; Organic chemistry","score_opus":0.0072407732073901075,"score_gpt":0.2632596440026657,"score_spread":0.25601887079527563,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2324644336","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9322501,0.031218035,0.017908854,0.0012647259,0.00082497316,0.00035976688,0.0017756323,0.0012258887,0.013172075],"genre_scores_gemma":[0.9863179,0.0037528428,0.005520376,0.00041046515,0.00010895034,0.000057988487,0.00084154494,0.00010636887,0.0028834543],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999295,0.000171286,0.000084930696,0.0001455508,0.0001394278,0.00016388987],"domain_scores_gemma":[0.9986299,0.0007590135,0.00014421467,0.00010533147,0.00014855918,0.00021300302],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00085696357,0.0013545454,0.001046832,0.0003880047,0.00022180432,0.0012129823,0.0012804632,0.0007286032,0.003331339],"category_scores_gemma":[0.0020299493,0.00039160642,0.00054533617,0.0002457347,0.000652232,0.001154556,0.0008686677,0.0010145617,0.0008051935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037390813,0.0001659588,0.0011095417,0.0008649353,0.00012756481,0.0004250928,0.00014112613,0.0011221438,0.9789153,0.001643655,0.00038387327,0.011361805],"study_design_scores_gemma":[0.00004744117,0.00039791083,0.00040535437,0.00001650895,0.000029185514,0.000093114926,0.0000151038785,0.00092562364,0.99528694,0.00018957347,0.0025771337,0.000015981837],"about_ca_topic_score_codex":0.001384728,"about_ca_topic_score_gemma":0.00078940624,"teacher_disagreement_score":0.003331339,"about_ca_system_score_codex":0.00046496547,"about_ca_system_score_gemma":0.000614916,"threshold_uncertainty_score":0.0111444},"labels":[],"label_agreement":null},{"id":"W2324799017","doi":"10.3389/fcell.2016.00027","title":"Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction","year":2016,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Tumor microenvironment; Angiogenesis; Cancer research; Immune system; Biology; Tumor hypoxia; Metastasis; Tumor progression; Cancer cell; Hypoxia (environmental); Immunology; Cancer; Medicine; Chemistry; Radiation therapy; Internal medicine","score_opus":0.015260222032373674,"score_gpt":0.2309502723769541,"score_spread":0.21569005034458041,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2324799017","genre_codex":"empirical","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90745616,0.038458448,0.036936317,0.0013098202,0.0003616642,0.00065494416,0.00066034007,0.0005977982,0.013564521],"genre_scores_gemma":[0.97051996,0.013899794,0.009850561,0.00044101707,0.00006521518,0.0003401376,0.000374949,0.0000370096,0.0044713723],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998995,0.000014615512,0.0000053959375,0.000019576637,0.000023054668,0.000037970105],"domain_scores_gemma":[0.9999584,0.00000378267,0.000011998851,0.0000028973486,0.0000048544516,0.00001798004],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016717578,0.00037606602,0.00038727466,0.00034564067,0.00009742716,0.0004308796,0.00028038895,0.0002918082,0.00083385466],"category_scores_gemma":[0.00007434955,0.00013206061,0.00028683548,0.00020137345,0.00016856194,0.00029875463,0.0003466032,0.00083943154,0.00017255478],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00052402046,0.0006406897,0.00021361599,0.0005221067,0.000076378725,0.00020209928,0.000055407,0.0021421616,0.9429591,0.0023422062,0.0010287291,0.049293574],"study_design_scores_gemma":[0.00070897955,0.008656964,0.005882313,0.00014426436,0.0004413799,0.0015419738,0.00014615727,0.015554972,0.89610314,0.0022044173,0.06854722,0.00006811434],"about_ca_topic_score_codex":0.00021201915,"about_ca_topic_score_gemma":0.00075546064,"teacher_disagreement_score":0.00083385466,"about_ca_system_score_codex":0.0002905146,"about_ca_system_score_gemma":0.00021848983,"threshold_uncertainty_score":0.002789557},"labels":[],"label_agreement":null},{"id":"W2325929726","doi":"10.1021/la501333s","title":"Electropolymerized Carbonic Anhydrase Immobilization for Carbon Dioxide Capture","year":2014,"lang":"en","type":"article","venue":"Langmuir","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Carbonic anhydrase; Chemistry; Solvent; Amine gas treating; Immobilized enzyme; Aqueous solution; Chemical engineering; Carbon dioxide; Carbonation; Biocatalysis; Catalysis; Organic chemistry; Enzyme; Reaction mechanism","score_opus":0.004441069089654044,"score_gpt":0.2161427214986415,"score_spread":0.21170165240898745,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2325929726","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98096246,0.0030819636,0.014217822,0.00013068267,0.000058632995,0.000032629978,0.00012263503,0.00012481655,0.0012684931],"genre_scores_gemma":[0.9909916,0.0010881197,0.0062023974,0.000023276707,0.000014456504,0.000015125326,0.00012753678,0.000017199904,0.001520455],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998343,0.000019918454,0.000012767509,0.00003645563,0.00006459873,0.00003190424],"domain_scores_gemma":[0.999899,0.000024968427,0.000024698584,0.000011890064,0.000024408393,0.000014962458],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682549,0.00041224444,0.00022107466,0.00025448034,0.00013454517,0.00026621783,0.0002710652,0.00042162978,0.00060476555],"category_scores_gemma":[0.00021581993,0.00014980182,0.0002612872,0.00021964971,0.00017729167,0.00026001805,0.00016755973,0.00037132506,0.00026628055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000009273643,0.0000067859523,0.000037363552,0.000017204395,0.0000027527399,0.000019257519,0.0000033694737,0.000041733725,0.9990839,0.000025504187,0.000009440204,0.00074344187],"study_design_scores_gemma":[0.0000017191142,0.000034822624,0.0004343044,0.000001497723,0.0000043690243,0.0000461393,0.0000029067198,0.0006882762,0.99825186,0.000006525174,0.0005247029,0.0000028765044],"about_ca_topic_score_codex":0.0009815515,"about_ca_topic_score_gemma":0.0022674482,"teacher_disagreement_score":0.0009815515,"about_ca_system_score_codex":0.00026891936,"about_ca_system_score_gemma":0.00022571227,"threshold_uncertainty_score":0.0020231605},"labels":[],"label_agreement":null},{"id":"W2326038632","doi":"10.1055/s-0034-1382612","title":"Novel enzyme inhibiting natural products from medicinally important plants","year":2014,"lang":"en","type":"article","venue":"Planta Medica","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Winnipeg","funders":"","keywords":"Natural product; Enzyme; Drug discovery; Biochemistry; Biology; Computational biology; Pharmacology","score_opus":0.008845795831909387,"score_gpt":0.217894636538515,"score_spread":0.20904884070660562,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2326038632","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5497257,0.29644758,0.05951198,0.0032496804,0.0018100664,0.0009079167,0.005582777,0.000792223,0.081972085],"genre_scores_gemma":[0.8157556,0.123105004,0.028032085,0.0017710322,0.00052797596,0.00031995398,0.0039414377,0.00007312998,0.026473906],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999577,0.0000052005676,0.0000033815609,0.00000780793,0.000016096916,0.000009896803],"domain_scores_gemma":[0.99996316,0.0000053628264,0.000008133895,0.0000021775745,0.00000995479,0.000011228511],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000089732035,0.00048462773,0.00028833057,0.0005419718,0.00020451822,0.00025451262,0.00023925169,0.00028379975,0.0027399736],"category_scores_gemma":[0.00009685543,0.00013747676,0.00037629675,0.00037178272,0.00016408873,0.00036625107,0.00021812598,0.00071201427,0.0008395571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002838622,0.00031496992,0.00040318182,0.0019621537,0.000048620284,0.0013670897,0.00013626821,0.00086492253,0.9182182,0.0038098607,0.003240541,0.06935045],"study_design_scores_gemma":[0.00020234851,0.0023144856,0.0046927934,0.00028622782,0.00017676357,0.0034303835,0.00009452796,0.0017796698,0.7494577,0.0024458678,0.23505105,0.000068198024],"about_ca_topic_score_codex":0.00024680447,"about_ca_topic_score_gemma":0.0004921657,"teacher_disagreement_score":0.0027399736,"about_ca_system_score_codex":0.00016385078,"about_ca_system_score_gemma":0.00019752073,"threshold_uncertainty_score":0.0091661215},"labels":[],"label_agreement":null},{"id":"W2393502792","doi":"","title":"Studies on the Dilution Refolding and Aggregation Interaction of Bovine Carbonic Anhydrase B Induced by Urea","year":2010,"lang":"en","type":"article","venue":"","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Science North","funders":"","keywords":"Chemistry; Urea; Carbonic anhydrase; Dilution; Chromatography; Size-exclusion chromatography; Dissociation (chemistry); Enzyme; Organic chemistry","score_opus":0.01876151625594,"score_gpt":0.2776275457287417,"score_spread":0.2588660294728017,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2393502792","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9879397,0.0025939022,0.007903671,0.000093932154,0.000029668587,0.000043984783,0.00012582283,0.0000792171,0.0011899915],"genre_scores_gemma":[0.98815405,0.001624656,0.00726111,0.00013803755,0.000022399796,0.00005572032,0.00044083322,0.00004879067,0.0022543855],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997217,0.000052377138,0.000021507387,0.000051982028,0.00009975605,0.00005272756],"domain_scores_gemma":[0.9997284,0.00007449967,0.000055204913,0.000019975694,0.00008737306,0.000034565503],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036644278,0.00035419755,0.00031549585,0.00016099545,0.00020126728,0.00016405697,0.00023196096,0.00025470366,0.00035332926],"category_scores_gemma":[0.00051676633,0.0001445475,0.0003723584,0.0001861237,0.00015000394,0.00035897267,0.0001623734,0.0005902588,0.00017917603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000027911801,0.000011568894,0.00017364541,0.000025191646,0.000004991441,0.000037112048,0.00003614154,0.000044720444,0.99889416,0.000029122997,0.000012884549,0.0007026656],"study_design_scores_gemma":[0.0000053223876,0.0001536804,0.003463686,0.00000393376,0.000014190435,0.00013372846,0.000020986268,0.0011715626,0.99413365,0.000024172006,0.0008655532,0.000009524245],"about_ca_topic_score_codex":0.0021134536,"about_ca_topic_score_gemma":0.0015593302,"teacher_disagreement_score":0.0021134536,"about_ca_system_score_codex":0.00030504662,"about_ca_system_score_gemma":0.00013968388,"threshold_uncertainty_score":0.0042023063},"labels":[],"label_agreement":null},{"id":"W2510305868","doi":"10.1371/journal.pone.0161040","title":"The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Newfoundland and Labrador; KWF Kankerbestrijding; Università degli Studi di Firenze; ZonMw; Health Foundation Limburg","keywords":"Doxorubicin; In vivo; Pharmacology; Chemistry; IC50; Extracellular; Cell culture; Viability assay; In vitro; Cancer research; Chemotherapy; Medicine; Biochemistry; Biology; Internal medicine","score_opus":0.022275366894694865,"score_gpt":0.20530006117077645,"score_spread":0.1830246942760816,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2510305868","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99294996,0.0041176593,0.0007996152,0.00013365792,0.000047738944,0.00003564532,0.00020026216,0.00006237118,0.0016530819],"genre_scores_gemma":[0.99413824,0.0023865537,0.00078178797,0.00005296111,0.000019300993,0.000033102388,0.00037512617,0.000011887131,0.0022011348],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992776,0.00001443354,0.000006782577,0.000012470167,0.00001867171,0.00001981187],"domain_scores_gemma":[0.9999429,0.000012331822,0.000014276734,0.0000036256145,0.0000097207085,0.000017096043],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000094411196,0.00024269751,0.00037846123,0.00016631576,0.00008430346,0.00021861173,0.00019071366,0.00020853165,0.0015392313],"category_scores_gemma":[0.00011886899,0.00009089995,0.00020615084,0.000119667144,0.00014199737,0.00016793128,0.00014258758,0.0004082507,0.0002259052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00096976437,0.00012750078,0.0003196355,0.00011483002,0.00002534603,0.000037145455,0.00001553479,0.00023411945,0.99114096,0.00006368079,0.00024516985,0.0067061256],"study_design_scores_gemma":[0.00012718907,0.0025624782,0.003914011,0.00001020144,0.000068297435,0.00010821938,0.000023623299,0.001411718,0.98780257,0.000027660028,0.003935649,0.000008482525],"about_ca_topic_score_codex":0.0007176234,"about_ca_topic_score_gemma":0.0015038542,"teacher_disagreement_score":0.0015392313,"about_ca_system_score_codex":0.00024144702,"about_ca_system_score_gemma":0.00020538567,"threshold_uncertainty_score":0.0051492453},"labels":[],"label_agreement":null},{"id":"W2516129876","doi":"10.1016/j.carpath.2016.08.003","title":"Carbonic anhydrase inhibitors reduce cardiac dysfunction after sustained coronary artery ligation in rats","year":2016,"lang":"en","type":"article","venue":"Cardiovascular Pathology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Agencia Nacional de Promoción Científica y Tecnológica; Fondo para la Investigación Científica y Tecnológica; Consejo Nacional de Investigaciones Científicas y Técnicas; University of Alberta","keywords":"Internal medicine; Ligation; Endocrinology; Cardiac function curve; Carnivora; Fissipedia; Medicine; Chemistry; Heart failure; Cardiology","score_opus":0.005371156906460187,"score_gpt":0.19801335655931032,"score_spread":0.19264219965285012,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2516129876","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9936407,0.0017364844,0.0021175588,0.00055111386,0.00017402883,0.000045717814,0.00034780428,0.0002702265,0.0011163712],"genre_scores_gemma":[0.9891451,0.0019011407,0.0018756286,0.00017370781,0.000095809235,0.00010611712,0.0005274574,0.00009369377,0.006081196],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996792,0.000036871515,0.000028976132,0.000058729885,0.000054841974,0.00014142359],"domain_scores_gemma":[0.99919695,0.000054070053,0.00025572703,0.00008631178,0.000074323216,0.00033261516],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032835317,0.0012676385,0.0010715751,0.00096581655,0.0005493108,0.00054836896,0.0007663965,0.00079614745,0.0020453054],"category_scores_gemma":[0.00036281347,0.00056072173,0.0006014383,0.00040532585,0.0010202014,0.00068977126,0.00034572967,0.0020140603,0.00039008402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.012532155,0.0011069844,0.00061272254,0.00009853463,0.00008444204,0.00020757048,0.00006243901,0.00021297083,0.97805244,0.00034494713,0.00033551906,0.006349406],"study_design_scores_gemma":[0.00047936806,0.004627222,0.0054416815,0.000017637689,0.00018350137,0.00016405858,0.0001381127,0.0013233883,0.9858882,0.00018662126,0.0015254973,0.000024726422],"about_ca_topic_score_codex":0.0028070307,"about_ca_topic_score_gemma":0.0064485734,"teacher_disagreement_score":0.0028070307,"about_ca_system_score_codex":0.0007289925,"about_ca_system_score_gemma":0.0009414097,"threshold_uncertainty_score":0.006842196},"labels":[],"label_agreement":null},{"id":"W2528172799","doi":"10.1016/j.ejpb.2016.09.018","title":"Inhibition of carbonic anhydrase IX in glioblastoma multiforme","year":2016,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital; Queen's University; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Calgary","keywords":"Temozolomide; Glioblastoma; Cancer research; Acetazolamide; U87; Brain tumor; Glioma; Carbonic anhydrase; Downregulation and upregulation; Programmed cell death; Medicine; Chemistry; Enzyme; Pathology; Internal medicine; Biochemistry; Apoptosis","score_opus":0.020447207539913317,"score_gpt":0.28233796414305196,"score_spread":0.26189075660313865,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2528172799","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98667395,0.009747143,0.0014461592,0.00017833192,0.000053933014,0.00005305819,0.00023845432,0.00006215139,0.0015468464],"genre_scores_gemma":[0.99333984,0.0039634905,0.0011946091,0.00003502217,0.000010145473,0.000027977045,0.00022109819,0.0000061693827,0.0012017285],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994504,0.000008894063,0.00000444758,0.0000088251845,0.000019083353,0.000013764191],"domain_scores_gemma":[0.99998045,0.000003155501,0.000004843534,0.0000015275604,0.00000426682,0.000005691228],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009193348,0.00024756545,0.00027735636,0.00020782067,0.0000843818,0.00014235012,0.0001394462,0.00014976213,0.00041004992],"category_scores_gemma":[0.000055988457,0.000059359998,0.00015730271,0.00014289164,0.00010431067,0.00010186007,0.000099234174,0.00026630212,0.00010330741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020429734,0.00007226027,0.00019095818,0.000106796615,0.000015388872,0.000050743558,0.000011093844,0.0002456492,0.9938956,0.0000793325,0.00014223093,0.004985686],"study_design_scores_gemma":[0.000054126238,0.0012791565,0.0031739892,0.000007071962,0.0000336739,0.00015856541,0.00000977851,0.0009329914,0.99081343,0.000029760164,0.0035031852,0.0000043670384],"about_ca_topic_score_codex":0.0031952716,"about_ca_topic_score_gemma":0.0062108412,"teacher_disagreement_score":0.0031952716,"about_ca_system_score_codex":0.0003866669,"about_ca_system_score_gemma":0.0002691064,"threshold_uncertainty_score":0.0063533783},"labels":[],"label_agreement":null},{"id":"W2530400939","doi":"10.1042/bcj20160773","title":"The structure, kinetics and interactions of the β-carboxysomal β-carbonic anhydrase, CcaA","year":2016,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University of Guelph","funders":"","keywords":"Dimer; Trimer; Chemistry; Carbonic anhydrase; Stereochemistry; Kinetics; Biophysics; Biochemistry; Enzyme; Biology","score_opus":0.005317319745025644,"score_gpt":0.2192068446736875,"score_spread":0.21388952492866187,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2530400939","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99647504,0.0007049174,0.00086812273,0.000085225365,0.000015269941,0.0000077743725,0.0003136413,0.000033082688,0.0014968285],"genre_scores_gemma":[0.997517,0.0002836879,0.0005731667,0.000017299826,0.0000057044635,0.000010291298,0.00056582363,0.00001274347,0.0010143784],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984956,0.000011262764,0.0000059187023,0.000047680656,0.000041236548,0.00004422636],"domain_scores_gemma":[0.9997775,0.00005529093,0.00004334123,0.000016227546,0.00005950634,0.00004809251],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619661,0.00019204961,0.00016055377,0.00014803285,0.0002344376,0.00038416332,0.00037196014,0.00023767358,0.0007449669],"category_scores_gemma":[0.00052313926,0.0002300847,0.00027473166,0.00014672312,0.00023638294,0.00037696134,0.00012799379,0.000813593,0.0003681519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020605624,0.00011467094,0.0063043977,0.00006765753,0.000029212115,0.00008069655,0.0001435759,0.002089864,0.98676795,0.0007220314,0.00047975924,0.0029941788],"study_design_scores_gemma":[0.000025836318,0.00022944053,0.07658753,0.0000121038,0.000028409708,0.00024243341,0.00018287396,0.061753366,0.8554783,0.0002794762,0.0051319585,0.000048320548],"about_ca_topic_score_codex":0.0089451885,"about_ca_topic_score_gemma":0.0049731466,"teacher_disagreement_score":0.0089451885,"about_ca_system_score_codex":0.0007323676,"about_ca_system_score_gemma":0.00032310272,"threshold_uncertainty_score":0.017786264},"labels":[],"label_agreement":null},{"id":"W2552721325","doi":"10.1016/j.bmcl.2016.11.052","title":"Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Saint-François d'Assise; Université Laval; PROTEO","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Sulfamide; Chemistry; Pyrimidine; In vitro; Stereochemistry; Bearing (navigation); Group (periodic table); Growth inhibition; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.012044601559754741,"score_gpt":0.21608945811517247,"score_spread":0.20404485655541774,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2552721325","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98250777,0.005007485,0.0059836153,0.00012973901,0.00008874337,0.00012700958,0.0005989181,0.00011415148,0.00544261],"genre_scores_gemma":[0.98949426,0.0026175913,0.004740736,0.000044793687,0.000022149754,0.00004573705,0.0004976592,0.000012260915,0.0025247887],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999323,0.000010255105,0.000009099568,0.000010115988,0.0000143262405,0.000023941906],"domain_scores_gemma":[0.9999399,0.000007922084,0.00001594411,0.0000074153004,0.000010970815,0.000017847207],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017126932,0.00037894864,0.00034040824,0.00018540192,0.00016836177,0.00014755946,0.00037718494,0.0002538423,0.0014607796],"category_scores_gemma":[0.00012920138,0.00013056447,0.00025074746,0.00023352004,0.0001588183,0.00022070188,0.00015273716,0.00030667288,0.00028998413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004565422,0.00016516841,0.0002453716,0.00031377553,0.000028417184,0.0006022695,0.000118638796,0.00137629,0.97651917,0.0009631791,0.00036115048,0.018850068],"study_design_scores_gemma":[0.00010312812,0.0034650825,0.0017966526,0.000016119895,0.000060814844,0.0005202831,0.000029539573,0.0011922912,0.981247,0.00011485424,0.011429262,0.000024866229],"about_ca_topic_score_codex":0.0007147153,"about_ca_topic_score_gemma":0.0012308512,"teacher_disagreement_score":0.0014607796,"about_ca_system_score_codex":0.00024489503,"about_ca_system_score_gemma":0.00030702772,"threshold_uncertainty_score":0.004886806},"labels":[],"label_agreement":null},{"id":"W2560327951","doi":"10.1002/cctc.201601433","title":"Explicit Water Molecules Play a Key Role in the Mechanism of Rhodium‐Substituted Human Carbonic Anhydrase","year":2016,"lang":"en","type":"article","venue":"ChemCatChem","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Carbonic anhydrase; Chemistry; Formic acid; Rhodium; Catalysis; Molecule; Combinatorial chemistry; Metathesis; Cofactor; Rate-determining step; Organic chemistry; Enzyme; Polymerization","score_opus":0.008528163593870349,"score_gpt":0.21883314791063835,"score_spread":0.210304984316768,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2560327951","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9549017,0.0016991129,0.03766358,0.00073103036,0.00008423183,0.000041170584,0.00006759162,0.00019691727,0.004614662],"genre_scores_gemma":[0.9968765,0.00037118414,0.0018027778,0.000034378718,0.0000034884636,0.000009613109,0.000030090612,0.000015893307,0.00085619075],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999436,0.000010124692,0.0000023959844,0.00001162592,0.00001545257,0.000016779015],"domain_scores_gemma":[0.999949,0.000020356307,0.0000091574375,0.0000064479427,0.0000064390883,0.000008633265],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017340256,0.00035191182,0.00021114663,0.000050977305,0.00017762315,0.00024060065,0.00048900035,0.00037149576,0.0013341467],"category_scores_gemma":[0.00027290187,0.00015785565,0.0001732596,0.000044252745,0.00046261106,0.00055108574,0.00028992578,0.00040028052,0.00023170409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002778088,0.00006349614,0.0008040628,0.00022070014,0.00005014037,0.00055819645,0.00013340781,0.012752763,0.95345384,0.021304956,0.00044163121,0.009938982],"study_design_scores_gemma":[0.00011982672,0.00037529666,0.0016309617,0.00002223592,0.00006089717,0.00039567315,0.000120711724,0.09506808,0.8905565,0.007503568,0.004104625,0.0000415228],"about_ca_topic_score_codex":0.0011686584,"about_ca_topic_score_gemma":0.0006980843,"teacher_disagreement_score":0.0013341467,"about_ca_system_score_codex":0.00025000767,"about_ca_system_score_gemma":0.00020320016,"threshold_uncertainty_score":0.004463196},"labels":[],"label_agreement":null},{"id":"W2604362788","doi":"10.1080/14756366.2017.1308928","title":"Design, synthesis and evaluation of<sup>18</sup>F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging","year":2017,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cationic polymerization; Carbonic anhydrase; Tumor hypoxia; Enzyme; Pet imaging; Imaging agent; Specific activity; In vivo; Biochemistry; Nuclear medicine; Positron emission tomography; Medicine; Internal medicine; Biology","score_opus":0.026448477477184873,"score_gpt":0.2964178657608086,"score_spread":0.2699693882836237,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2604362788","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.867765,0.0072849626,0.10774744,0.00057842303,0.00012453746,0.002386265,0.0014116237,0.00049475825,0.012206988],"genre_scores_gemma":[0.9223439,0.0046931067,0.06370539,0.000165947,0.000036405007,0.0005883057,0.001061959,0.000102069025,0.0073029734],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985385,0.000025387191,0.000013546344,0.000036788526,0.000039391463,0.000031029336],"domain_scores_gemma":[0.99985087,0.000014818981,0.00005358183,0.000010758298,0.00003284569,0.000036981637],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039531107,0.00065359345,0.00037455023,0.00019300253,0.00022547266,0.0005826059,0.0005689925,0.00054461334,0.0008945087],"category_scores_gemma":[0.00030403273,0.00030184985,0.00025703805,0.00020647465,0.00025637378,0.00039473304,0.00016950641,0.00053555076,0.00063305843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022923181,0.00009553043,0.000102235674,0.00013170243,0.000018552262,0.00012521388,0.000030362156,0.001735896,0.9881345,0.0008890368,0.00025493253,0.008252795],"study_design_scores_gemma":[0.000087152286,0.0008468998,0.00019823354,0.000007272501,0.000024343746,0.00025559845,0.000007452586,0.0014989584,0.9884847,0.000056249573,0.008520595,0.000012503155],"about_ca_topic_score_codex":0.00086795824,"about_ca_topic_score_gemma":0.0013426968,"teacher_disagreement_score":0.0008945087,"about_ca_system_score_codex":0.00068732264,"about_ca_system_score_gemma":0.0005783596,"threshold_uncertainty_score":0.0049868226},"labels":[],"label_agreement":null},{"id":"W2619907503","doi":"10.3390/molecules22060915","title":"Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type Ca2+ Current Inhibitors for Hypotensive Agent Discovery","year":2017,"lang":"en","type":"review","venue":"Molecules","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Université de Poitiers; Centre National de la Recherche Scientifique; Ministère de l'Enseignement Supérieur et de la Recherche; Agence Universitaire de la Francophonie","keywords":"Natural product; Superacid; Chemistry; Identification (biology); Lead compound; Combinatorial chemistry; Natural compound; Lead (geology); Pharmacology; Computational biology; Biochemical engineering; Biochemistry; Medicine; Biology; Engineering; Catalysis; In vitro","score_opus":0.05972100952228874,"score_gpt":0.3557153653196061,"score_spread":0.29599435579731737,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2619907503","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00082027644,0.99532396,0.0006394922,0.00019923101,0.00016590746,0.000017956323,0.000027860726,0.000014155249,0.0027913107],"genre_scores_gemma":[0.004816526,0.9916869,0.0010239392,0.0002296528,0.00009629593,0.000020640644,0.000052219653,0.000006129467,0.002067713],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998258,0.000028065506,0.000019066489,0.00003323181,0.000069008456,0.000024837691],"domain_scores_gemma":[0.99983,0.00007435718,0.000022776538,0.000008784421,0.00004524906,0.000018795383],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005838976,0.0009070932,0.0011272685,0.0019570878,0.00030321468,0.0010626536,0.000763309,0.0010248834,0.0028123374],"category_scores_gemma":[0.00052600354,0.0003743983,0.00057395076,0.0019845087,0.00045361384,0.0011809759,0.0007149261,0.0015941921,0.001996098],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012298561,0.00022276319,0.0002223631,0.017805452,0.00012959023,0.0015054473,0.00020335618,0.0010226717,0.013968931,0.01603512,0.01923521,0.92952615],"study_design_scores_gemma":[0.000031061765,0.00018523092,0.00039935767,0.0014275665,0.00010204498,0.0024060383,0.000064313186,0.00023395894,0.0045754067,0.0018576516,0.9886882,0.000029126422],"about_ca_topic_score_codex":0.00079708576,"about_ca_topic_score_gemma":0.0017837264,"teacher_disagreement_score":0.0028123374,"about_ca_system_score_codex":0.00050526945,"about_ca_system_score_gemma":0.0008225235,"threshold_uncertainty_score":0.009408176},"labels":[],"label_agreement":null},{"id":"W2729040843","doi":"10.1038/onc.2017.219","title":"The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion","year":2017,"lang":"en","type":"article","venue":"Oncogene","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Invadopodia; Biology; Cortactin; Cell biology; Integrin; Tumor microenvironment; Tumor progression; Cancer research; Cancer cell; Biochemistry; Cell; Cancer; Cytoskeleton","score_opus":0.011911341378276877,"score_gpt":0.24408115185303536,"score_spread":0.2321698104747585,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2729040843","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99242073,0.0015758413,0.004193558,0.00013543363,0.0000073920023,0.00001179847,0.00034772942,0.00004597577,0.0012616699],"genre_scores_gemma":[0.99056226,0.0008603051,0.0039493125,0.000050912604,0.00000766976,0.00002182481,0.0007439539,0.000011565496,0.00379226],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999238,0.000007005664,0.0000035146893,0.000023432996,0.00002279993,0.000019521984],"domain_scores_gemma":[0.9999558,0.0000066140533,0.000014021301,0.000004482276,0.0000069877983,0.0000120166615],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000790608,0.00021535456,0.00015945925,0.00022675803,0.00022142209,0.00025541935,0.000122072,0.0002367736,0.0014674971],"category_scores_gemma":[0.00009073341,0.00011908545,0.0002520187,0.00014049352,0.00011001171,0.00020536668,0.00022017852,0.0002379089,0.0003167753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000084661704,0.000005647185,0.001181149,0.000028346494,0.000007435377,0.00007707859,0.000020507585,0.000039221184,0.9973506,0.00009455818,0.000029632876,0.0010812253],"study_design_scores_gemma":[0.000013387484,0.00011987521,0.10544906,0.000008847954,0.00004059979,0.0011671372,0.00010986958,0.0036868865,0.8846627,0.00016954099,0.004563498,0.000008566486],"about_ca_topic_score_codex":0.0012108404,"about_ca_topic_score_gemma":0.0019751715,"teacher_disagreement_score":0.0014674971,"about_ca_system_score_codex":0.0003488995,"about_ca_system_score_gemma":0.0001767957,"threshold_uncertainty_score":0.004909277},"labels":[],"label_agreement":null},{"id":"W2761834263","doi":"10.1016/j.gene.2017.10.008","title":"Molecular cloning and characterization of secretory carbonic anhydrase VI in pufferfish ( Takifugu rubripes )","year":2017,"lang":"en","type":"article","venue":"Gene","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Genomics; University of Ottawa","funders":"","keywords":"Takifugu rubripes; Biology; Peptide sequence; Fugu; Carbonic anhydrase; Complementary DNA; Amino acid; Biochemistry; Signal peptide; Sequence alignment; Open reading frame; Sequence analysis; Molecular cloning; Molecular biology; Genetics; Gene; Zebrafish; Enzyme","score_opus":0.006861930422635257,"score_gpt":0.2228170539333905,"score_spread":0.21595512351075524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2761834263","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99115294,0.0009212539,0.0055004316,0.0001825246,0.00003711375,0.000048295205,0.00092362333,0.000066073255,0.001167723],"genre_scores_gemma":[0.97576094,0.0009281982,0.008173046,0.00008563297,0.000032856587,0.00006279674,0.005786089,0.00006057169,0.009109947],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999441,0.0000028909812,0.000005968919,0.00001788886,0.000016618531,0.000012616887],"domain_scores_gemma":[0.9998479,0.000026373029,0.000039974857,0.000017622426,0.000025332936,0.000042717773],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000083612846,0.0003452425,0.00027790427,0.0003038922,0.0002217982,0.00022558919,0.00036415047,0.00026906145,0.0006657004],"category_scores_gemma":[0.00013197878,0.00020649767,0.00042819008,0.00017000642,0.0002568989,0.00022072143,0.00017631844,0.0005732373,0.00048097575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000025135643,0.0000066011953,0.00018317961,0.000021525051,0.0000015861871,0.000054182194,0.000019428227,0.000023620092,0.99905354,0.000073624906,0.000012495296,0.0005251143],"study_design_scores_gemma":[0.000037424645,0.00028479518,0.033555903,0.000017047589,0.000064554304,0.0010299013,0.00015910868,0.001328878,0.9554715,0.00015257603,0.00788279,0.00001538976],"about_ca_topic_score_codex":0.0033447216,"about_ca_topic_score_gemma":0.0027161995,"teacher_disagreement_score":0.0033447216,"about_ca_system_score_codex":0.00042243357,"about_ca_system_score_gemma":0.00035041905,"threshold_uncertainty_score":0.0066505075},"labels":[],"label_agreement":null},{"id":"W2765413024","doi":"10.7150/thno.21848","title":"Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX","year":2017,"lang":"en","type":"review","venue":"Theranostics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Leading Edge Endowment Fund","keywords":"Monoclonal antibody; Cancer research; Medicine; Antibody; Cancer; Small molecule; Metastasis; Radioimmunotherapy; Pharmacology; Chemistry; Immunology; Internal medicine; Biochemistry","score_opus":0.05294396114866762,"score_gpt":0.32920020601729255,"score_spread":0.27625624486862493,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2765413024","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0002110016,0.996917,0.00022711576,0.0005772769,0.00037484488,0.0000055652836,0.0000231407,0.00001403964,0.0016499523],"genre_scores_gemma":[0.0009918682,0.99709177,0.00024948298,0.00035266762,0.00020520015,0.000009855046,0.000029715507,0.0000029089042,0.0010665124],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998567,0.000023561344,0.000016315113,0.000027273934,0.00005438563,0.00002179754],"domain_scores_gemma":[0.9997757,0.00008800148,0.000030162675,0.00000808755,0.00006316122,0.00003491678],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00055993075,0.0006866755,0.0009902603,0.0016412906,0.00027271255,0.0010372986,0.0007990519,0.0011112865,0.0035580029],"category_scores_gemma":[0.0006030656,0.00027286314,0.0004366989,0.0016464179,0.0004153605,0.0017150505,0.0007409878,0.0018756193,0.0022067481],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007687655,0.000074684045,0.00012352495,0.012455095,0.000058835136,0.0002293935,0.000085955966,0.0005369175,0.0031886944,0.0077973926,0.039831728,0.9355409],"study_design_scores_gemma":[0.00001191315,0.000060202343,0.00031446217,0.0016777907,0.000039869457,0.0005454453,0.000038370174,0.00011780788,0.00049100426,0.0021342773,0.99455607,0.0000128571555],"about_ca_topic_score_codex":0.00069364277,"about_ca_topic_score_gemma":0.0013042047,"teacher_disagreement_score":0.0035580029,"about_ca_system_score_codex":0.0006297784,"about_ca_system_score_gemma":0.0009189305,"threshold_uncertainty_score":0.01190275},"labels":[],"label_agreement":null},{"id":"W2793047804","doi":"10.3390/metabo8010020","title":"Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX","year":2018,"lang":"en","type":"review","venue":"Metabolites","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Tumor microenvironment; Cancer cell; Tumor hypoxia; Hypoxia (environmental); Biology; Transporter; Interactome; Biochemistry; Chemistry; Cancer; Cell biology; Cancer research; Tumor cells; Medicine","score_opus":0.015231512975606326,"score_gpt":0.2603126602032459,"score_spread":0.24508114722763957,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2793047804","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00019234687,0.9976732,0.00016987699,0.00044652645,0.00024109763,0.000004916482,0.00003072309,0.000011739949,0.0012295967],"genre_scores_gemma":[0.0007306624,0.9978338,0.00018939111,0.00017013443,0.00012714887,0.0000068240092,0.00003712201,0.0000019044087,0.0009030521],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998995,0.000012742285,0.000016677946,0.000021990485,0.000035766592,0.000013304949],"domain_scores_gemma":[0.9998524,0.000048692575,0.00002507732,0.0000048679967,0.00005143658,0.000017423643],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034429802,0.0006292339,0.000783182,0.0013080194,0.00024437744,0.0008233022,0.00060421077,0.0007979905,0.0028096882],"category_scores_gemma":[0.00043855113,0.00024279565,0.0003564984,0.0012432773,0.0002592111,0.0009339076,0.00054042146,0.0014121104,0.0019196329],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009384802,0.000052365118,0.00019977217,0.014731569,0.00009129678,0.00022291212,0.000055552762,0.00040147261,0.0032372645,0.005437719,0.036266927,0.9392093],"study_design_scores_gemma":[0.000012501111,0.00005486255,0.0006332272,0.0013824122,0.00006637717,0.0006060642,0.000027709812,0.000098521945,0.0006985858,0.0011703409,0.9952382,0.00001122143],"about_ca_topic_score_codex":0.0010290085,"about_ca_topic_score_gemma":0.002026438,"teacher_disagreement_score":0.0028096882,"about_ca_system_score_codex":0.0006311827,"about_ca_system_score_gemma":0.00092871976,"threshold_uncertainty_score":0.009399295},"labels":[],"label_agreement":null},{"id":"W2800240853","doi":"10.1016/j.jinorgbio.2018.04.009","title":"Evaluation of 99mTc-sulfonamide and sulfocoumarin derivatives for imaging carbonic anhydrase IX expression","year":2018,"lang":"en","type":"article","venue":"Journal of Inorganic Biochemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University; BC Cancer Agency","funders":"Kansai University","keywords":"Chemistry; Carbonic anhydrase; Sulfonamide; Rhenium; Carbonic Anhydrase I; Carbonic anhydrase II; Ligand (biochemistry); Stereochemistry; Medicinal chemistry; Enzyme; Receptor; Biochemistry; Organic chemistry","score_opus":0.012784474823944219,"score_gpt":0.27426387723170553,"score_spread":0.2614794024077613,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2800240853","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9907222,0.0014055923,0.005987573,0.000113873495,0.000019964857,0.000063464286,0.00009450678,0.00004964011,0.0015433047],"genre_scores_gemma":[0.9848018,0.001379523,0.010772793,0.000032030483,0.000010321238,0.00007885719,0.00026375527,0.000045426787,0.0026154814],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99972326,0.00010127015,0.000016468717,0.00004824696,0.000059570335,0.00005117747],"domain_scores_gemma":[0.9997123,0.00010531367,0.000057624202,0.000026409469,0.00005361407,0.000044657387],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007569899,0.00052112143,0.00030774513,0.00022039929,0.00021900852,0.00045034947,0.00042647915,0.0006123564,0.00059362553],"category_scores_gemma":[0.0005066519,0.00028194804,0.00019044147,0.00026376414,0.00035124485,0.00036176038,0.00016269466,0.00050321396,0.00012978629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002854132,0.000034843073,0.00010249215,0.000026401554,0.000006905159,0.00003461092,0.000021086365,0.0001297957,0.9981744,0.00015392808,0.000018797577,0.0010111446],"study_design_scores_gemma":[0.000013909716,0.00023290915,0.0003546851,0.000001780773,0.000014996448,0.00006339316,0.0000079158335,0.0010272426,0.9977228,0.000011186624,0.0005460923,0.000003039348],"about_ca_topic_score_codex":0.0023971437,"about_ca_topic_score_gemma":0.0029714662,"teacher_disagreement_score":0.0023971437,"about_ca_system_score_codex":0.0006817076,"about_ca_system_score_gemma":0.00064604596,"threshold_uncertainty_score":0.0049461722},"labels":[],"label_agreement":null},{"id":"W2887378393","doi":"10.1158/1538-7445.am2018-2102","title":"Abstract 2102: UFH-001: A novel triple-negative, CAIX-positive cell line for small-molecule targeting of human breast cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SignalChem (Canada)","funders":"","keywords":"Triple-negative breast cancer; Cancer research; Context (archaeology); Metastasis; Metastatic breast cancer; Breast cancer; Cancer; Cell culture; Medicine; Biology; Internal medicine","score_opus":0.05550998769905873,"score_gpt":0.3783807602736805,"score_spread":0.32287077257462177,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2887378393","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.955671,0.006009576,0.014626589,0.0011710336,0.00040191872,0.00046039312,0.00926214,0.0006430444,0.0117543135],"genre_scores_gemma":[0.9515814,0.0027697466,0.012414333,0.00031824515,0.000049942213,0.0004452974,0.0140570635,0.00007762699,0.0182863],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998266,0.000018047069,0.000020310692,0.000037291546,0.00006790502,0.000029842684],"domain_scores_gemma":[0.99993825,0.000014536718,0.0000085271995,0.000009896366,0.000014360893,0.000014404773],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023103766,0.0003265422,0.0003830766,0.0002377436,0.00024848085,0.0002776352,0.0003338429,0.00045009906,0.0018862429],"category_scores_gemma":[0.00012708544,0.00009868948,0.0002368734,0.0003618221,0.00014302388,0.00015939312,0.00011825351,0.0006333306,0.0010619496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001172578,0.00010865132,0.00022250578,0.00007431009,0.0000072770054,0.00012018419,0.00003247758,0.00009118809,0.9958776,0.00023635886,0.0007944557,0.002317626],"study_design_scores_gemma":[0.000060829545,0.00056655536,0.003103153,0.0000088431925,0.00003352072,0.000851007,0.00003250901,0.0019627714,0.9777818,0.000047805206,0.015542173,0.000008987765],"about_ca_topic_score_codex":0.0022936969,"about_ca_topic_score_gemma":0.002188663,"teacher_disagreement_score":0.0022936969,"about_ca_system_score_codex":0.00028189615,"about_ca_system_score_gemma":0.00024709126,"threshold_uncertainty_score":0.0063101053},"labels":[],"label_agreement":null},{"id":"W2890474477","doi":"10.1038/s41396-018-0270-2","title":"Soil exchange rates of COS and CO18O differ with the diversity of microbial communities and their carbonic anhydrase enzymes","year":2018,"lang":"en","type":"article","venue":"The ISME Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"SLAC National Accelerator Laboratory; Directorate for Geosciences; Biological and Environmental Research; U.S. Department of Energy; European Commission; Division of Atmospheric and Geospace Sciences; Joint Genome Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Office of Science; Agence Nationale de la Recherche; European Research Council; National Science Foundation","keywords":"Biology; Carbonic anhydrase; Enzyme; Diversity (politics); Biochemistry; Ecology; Microbiology; Botany; Anthropology","score_opus":0.012983164772109104,"score_gpt":0.20885853777647093,"score_spread":0.1958753730043618,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2890474477","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9963574,0.00025061128,0.002233936,0.000023555316,0.0000032978974,0.000011311862,0.00063988386,0.000026510133,0.0004535336],"genre_scores_gemma":[0.9981762,0.00011484477,0.0011367232,0.0000138697715,0.000003574534,0.000011941515,0.0004263838,0.000010028069,0.000106474996],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995646,0.00004882953,0.000029829116,0.00021825144,0.00008453941,0.000054024626],"domain_scores_gemma":[0.99948406,0.00012575745,0.00017456959,0.000041252937,0.0001297905,0.000044603017],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00047879308,0.00056042627,0.00029053233,0.00070267386,0.00025514408,0.0009930488,0.00023738595,0.0003431004,0.00043880247],"category_scores_gemma":[0.0006469329,0.0002544306,0.0002638937,0.00086554006,0.00035215027,0.00078094366,0.0003152908,0.00027839595,0.00016799103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023398842,0.000067357694,0.31411934,0.00012896386,0.0001983345,0.000040323663,0.00015743628,0.0011373843,0.6698871,0.00018588231,0.000100923186,0.013742849],"study_design_scores_gemma":[0.00001320653,0.00014998428,0.8960022,0.000016903738,0.00007741601,0.00014114291,0.00044549923,0.013050517,0.08810748,0.00047649676,0.0014956527,0.000023512623],"about_ca_topic_score_codex":0.004337013,"about_ca_topic_score_gemma":0.0052093677,"teacher_disagreement_score":0.004337013,"about_ca_system_score_codex":0.00033162846,"about_ca_system_score_gemma":0.00027518492,"threshold_uncertainty_score":0.00862354},"labels":[],"label_agreement":null},{"id":"W2896468525","doi":"10.3389/fmicb.2018.02490","title":"Role of Extracellular Carbonic Anhydrase in Dissolved Inorganic Carbon Uptake in Alkaliphilic Phototrophic Biofilm","year":2018,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund","keywords":"Bicarbonate; Phototroph; Biofilm; Extracellular polymeric substance; Chemistry; Carbon dioxide; Total inorganic carbon; Cyanobacteria; Environmental chemistry; Dissolved organic carbon; Photosynthesis; Carbonic anhydrase; Carbonate; Biochemistry; Bacteria; Biology; Enzyme; Organic chemistry","score_opus":0.0038245829567444085,"score_gpt":0.1943290977580683,"score_spread":0.1905045148013239,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2896468525","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9948447,0.0015164106,0.002729642,0.00014641938,0.000014712266,0.000008560222,0.00013992825,0.000029067985,0.0005706282],"genre_scores_gemma":[0.9982967,0.0005191152,0.0008608916,0.000014941316,0.0000037304271,0.000006771707,0.000056668046,0.000004966141,0.00023631287],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998597,0.0000186344,0.000010956531,0.00003735653,0.000051102368,0.000022210615],"domain_scores_gemma":[0.9998975,0.000026775933,0.00003157191,0.0000058644277,0.000018762175,0.00001953758],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016405761,0.00044861014,0.00035598187,0.00011539933,0.0001456166,0.00056781014,0.00021514462,0.00041714316,0.00022198034],"category_scores_gemma":[0.00019952432,0.00013621962,0.0002442563,0.000116597694,0.0003234525,0.0002870382,0.00031002975,0.00037263945,0.00009541227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000038307313,0.000010044349,0.0011155558,0.000049173355,0.0000080430145,0.0000333265,0.00001984102,0.00045792118,0.9971933,0.000096039876,0.00001543834,0.000963072],"study_design_scores_gemma":[0.000014410708,0.00017529706,0.030908689,0.000014350529,0.000028754417,0.00012185347,0.00011959945,0.027631989,0.93885624,0.00043274864,0.0016678236,0.000028230355],"about_ca_topic_score_codex":0.002108901,"about_ca_topic_score_gemma":0.001247609,"teacher_disagreement_score":0.002108901,"about_ca_system_score_codex":0.00035078335,"about_ca_system_score_gemma":0.00033880386,"threshold_uncertainty_score":0.0041931868},"labels":[],"label_agreement":null},{"id":"W2900483416","doi":"10.1074/jbc.ra118.005536","title":"Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Stiftung Rheinland-Pfalz für Innovation; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Biochemistry; Residue (chemistry); Basigin; Amino acid; Binding site; Amino acid residue; Peptide sequence; Gene","score_opus":0.010581195219645985,"score_gpt":0.21186683515623742,"score_spread":0.20128563993659143,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2900483416","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.998109,0.00055775733,0.0005597743,0.00005090733,0.000006806338,0.0000055605724,0.000041825617,0.000015183872,0.0006532748],"genre_scores_gemma":[0.99763656,0.00029692627,0.00078301044,0.00005688373,0.000008285438,0.000008554417,0.00023427213,0.0000049824052,0.000970476],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998615,0.00002211632,0.0000058351293,0.000017907216,0.00003614736,0.000056529403],"domain_scores_gemma":[0.9999443,0.0000055905107,0.000013158509,0.0000048295447,0.000012193634,0.00002001075],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007404058,0.00014824064,0.00015363884,0.00013309471,0.00012018184,0.000179395,0.00011186197,0.0001920954,0.00055324537],"category_scores_gemma":[0.00014882514,0.00008343443,0.0002350159,0.000102731945,0.00007581961,0.00011692581,0.00023874102,0.00019203735,0.00021551704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000065638465,0.0000129216405,0.0013667536,0.000023740937,0.000009572978,0.000101194586,0.000018661436,0.000042520507,0.99680847,0.000082020546,0.0000729122,0.0013954655],"study_design_scores_gemma":[0.000044438708,0.00034259955,0.13258733,0.000021090807,0.00004300621,0.0011528442,0.00015168187,0.006638445,0.8518635,0.00016549384,0.0069727823,0.000016818056],"about_ca_topic_score_codex":0.0010134045,"about_ca_topic_score_gemma":0.0012753711,"teacher_disagreement_score":0.0010134045,"about_ca_system_score_codex":0.0003389565,"about_ca_system_score_gemma":0.0001237797,"threshold_uncertainty_score":0.0024592876},"labels":[],"label_agreement":null},{"id":"W2906035087","doi":"10.3390/molecules24010023","title":"A Flexible Synthesis of 68Ga-Labeled Carbonic Anhydrase IX (CAIX)-Targeted Molecules via CBT/1,2-Aminothiol Click Reaction","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TRIUMF","funders":"Fondation Leenaards; University of British Columbia","keywords":"Click chemistry; Chemistry; Bifunctional; Combinatorial chemistry; Radiochemistry; Biochemistry; Catalysis","score_opus":0.00836616169637736,"score_gpt":0.23432840457172305,"score_spread":0.2259622428753457,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2906035087","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91459066,0.0046579237,0.06990803,0.00031564446,0.000088703586,0.00044017684,0.00073360535,0.0010016692,0.008263503],"genre_scores_gemma":[0.9494771,0.0023534507,0.04128527,0.00015183208,0.000033194705,0.00028931396,0.00064127357,0.000075109376,0.0056935344],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998392,0.000014138668,0.0000115545445,0.000041170933,0.000051316834,0.000042555166],"domain_scores_gemma":[0.99992204,0.000008373943,0.00002441126,0.000008235301,0.0000127897,0.00002411936],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020882097,0.00060379313,0.00046387842,0.0003295904,0.0002145978,0.00028861387,0.00037263983,0.0003762193,0.0011856321],"category_scores_gemma":[0.00015248425,0.00026973258,0.00027078725,0.00033357472,0.00023055046,0.0002598768,0.0003484079,0.0004455532,0.000616028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000036676858,0.00002009199,0.0000988507,0.00007086998,0.000008546844,0.00012334686,0.000030258916,0.00035789164,0.99398065,0.0002799575,0.000104244275,0.0048886654],"study_design_scores_gemma":[0.000035426034,0.00029681323,0.0007889484,0.000005452576,0.00002303124,0.00033573995,0.000009757325,0.001096827,0.9918665,0.000048664828,0.00547345,0.00001929967],"about_ca_topic_score_codex":0.00091289246,"about_ca_topic_score_gemma":0.0017126364,"teacher_disagreement_score":0.0011856321,"about_ca_system_score_codex":0.00046390248,"about_ca_system_score_gemma":0.00036935293,"threshold_uncertainty_score":0.0039663315},"labels":[],"label_agreement":null},{"id":"W2944600762","doi":"10.1053/j.gastro.2019.05.004","title":"Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":232,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency; University of British Columbia; Pancreas Centre (Canada); Vancouver General Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; VGH and UBC Hospital Foundation; University of Pennsylvania","keywords":"Hypoxia (environmental); KRAS; Carbonic anhydrase; Pancreatic cancer; Cancer research; Chemistry; Cancer; Internal medicine; Medicine; Biochemistry; Enzyme; Oxygen; Colorectal cancer","score_opus":0.004139706509256099,"score_gpt":0.2104035935554428,"score_spread":0.2062638870461867,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2944600762","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.997338,0.00070670806,0.0007153468,0.00011308498,0.000016682197,0.000009769768,0.0003039089,0.000030966643,0.00076553546],"genre_scores_gemma":[0.9979596,0.00040283598,0.00039971116,0.000032822074,0.000004992444,0.000020666243,0.00036248236,0.0000059826816,0.00081086264],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999915,0.000011923059,0.000007326197,0.000017030427,0.000021038095,0.000027784883],"domain_scores_gemma":[0.99992454,0.000009338439,0.000022542228,0.000008497427,0.0000098266555,0.00002526344],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007868376,0.0001533144,0.00018820309,0.00009137132,0.0001613883,0.00026014575,0.00011068198,0.00016622207,0.0009779274],"category_scores_gemma":[0.000085919666,0.000082272236,0.00020815144,0.00010136241,0.00014808326,0.00016212261,0.00017428955,0.00036101174,0.00018115241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029815733,0.000025690602,0.0009949025,0.000028662289,0.000005901697,0.00006267677,0.000013892386,0.000079514655,0.9974496,0.000058547448,0.000088855195,0.00089354906],"study_design_scores_gemma":[0.00003155466,0.00038260702,0.033951562,0.00000897792,0.000018544477,0.00036009212,0.00009001491,0.0020401075,0.95994365,0.00006313,0.0031036376,0.0000060443213],"about_ca_topic_score_codex":0.0006877279,"about_ca_topic_score_gemma":0.00095364574,"teacher_disagreement_score":0.0009779274,"about_ca_system_score_codex":0.00027425247,"about_ca_system_score_gemma":0.00015185916,"threshold_uncertainty_score":0.0032715201},"labels":[],"label_agreement":null},{"id":"W2945184742","doi":"10.1158/2326-6066.cir-18-0657","title":"Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically","year":2019,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre for Advancing Health Outcomes; University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver Coastal Health; Canadian Centre for Applied Research in Cancer Control; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Immune checkpoint; Immune system; Cancer research; Tumor microenvironment; Melanoma; Immunotherapy; Blockade; PD-L1; Tumor hypoxia; Hypoxia (environmental); Biology; Medicine; Immunology; Chemistry; Internal medicine; Receptor; Radiation therapy","score_opus":0.02197598036315715,"score_gpt":0.30964866186925105,"score_spread":0.28767268150609393,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2945184742","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9961002,0.001266579,0.001065466,0.00013178837,0.000028552517,0.000035477056,0.00007156332,0.00004457223,0.0012559664],"genre_scores_gemma":[0.998287,0.0003623059,0.00035365517,0.000033714052,0.000009897433,0.000015874048,0.00006747162,0.0000034968832,0.0008664739],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995494,0.0000069989637,0.0000022950853,0.000009059794,0.000010662664,0.00001617105],"domain_scores_gemma":[0.99997425,0.000003305346,0.000008715165,0.0000019260322,0.000002780788,0.000009025654],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007099537,0.00013596061,0.0001641158,0.00008138541,0.000059978916,0.00017202596,0.00009655941,0.00009873711,0.0009412313],"category_scores_gemma":[0.000051621584,0.000043229116,0.000094117175,0.00005379971,0.00009590248,0.0000792242,0.00009813991,0.00032270004,0.00013424197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00057698216,0.00022714955,0.0007227009,0.000052779087,0.0000187616,0.000021624435,0.0000079567335,0.00036987197,0.9874765,0.00009661759,0.00023491184,0.01019419],"study_design_scores_gemma":[0.00027142782,0.0061635394,0.015094612,0.000013312158,0.0000712,0.00030967567,0.000028869721,0.004081562,0.96806437,0.00006946448,0.0058265463,0.000005391535],"about_ca_topic_score_codex":0.00045275086,"about_ca_topic_score_gemma":0.0012456438,"teacher_disagreement_score":0.0009412313,"about_ca_system_score_codex":0.00021694518,"about_ca_system_score_gemma":0.00015853882,"threshold_uncertainty_score":0.003148675},"labels":[],"label_agreement":null},{"id":"W2953217540","doi":"10.1002/chin.201210127","title":"ChemInform Abstract: Substituted Phenyl 4‐(2‐Oxoimidazolidin‐1‐yl)benzenesulfonamides as Antimitotics. Antiproliferative, Antiangiogenic and Antitumoral Activity, and Quantitative Structure—Activity Relationships.","year":2012,"lang":"en","type":"article","venue":"ChemInform","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Saint-François d'Assise","funders":"","keywords":"Chemistry; Stereochemistry; Combinatorial chemistry; Pharmacology","score_opus":0.025413182549719988,"score_gpt":0.2664224850098815,"score_spread":0.24100930246016153,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2953217540","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8947315,0.033982806,0.0169759,0.0008490432,0.00021312691,0.00028236533,0.005217633,0.0013329259,0.046414755],"genre_scores_gemma":[0.94996834,0.016552864,0.00934,0.00023212719,0.000042371303,0.00012762168,0.0041789473,0.000038021506,0.01951968],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990845,0.000017135999,0.0000047563444,0.000010828649,0.000040288367,0.0000185098],"domain_scores_gemma":[0.9999428,0.000008452877,0.000018350367,0.0000036026659,0.000013816437,0.000012918905],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002362171,0.00061757106,0.00025256138,0.00034866075,0.00012808596,0.0001590588,0.00033024623,0.00018748791,0.005563149],"category_scores_gemma":[0.00013450245,0.00019875495,0.00012519406,0.00030729597,0.00017817835,0.0001857783,0.00014584351,0.00029756498,0.0011868542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010976427,0.00022777775,0.00058097567,0.0005762206,0.000039053895,0.0001545086,0.00004750645,0.0011118362,0.96052855,0.0016602543,0.0030308391,0.030944908],"study_design_scores_gemma":[0.00032639236,0.001823185,0.003420729,0.000030243942,0.00007119643,0.00027827916,0.000019467456,0.001395819,0.9712385,0.00011196521,0.021265302,0.000018939121],"about_ca_topic_score_codex":0.0012290821,"about_ca_topic_score_gemma":0.0030026054,"teacher_disagreement_score":0.005563149,"about_ca_system_score_codex":0.0005109339,"about_ca_system_score_gemma":0.00054417097,"threshold_uncertainty_score":0.018610537},"labels":[],"label_agreement":null},{"id":"W2956512450","doi":"10.3390/cancers11071002","title":"Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Vetenskapsrådet","keywords":"Sunitinib; Metastasis; Angiogenesis; Cancer research; Triple-negative breast cancer; Medicine; Tumor hypoxia; Breast cancer; Metastatic breast cancer; Primary tumor; Hypoxia (environmental); Lung cancer; Cancer; Internal medicine; Radiation therapy; Chemistry","score_opus":0.010044429684261828,"score_gpt":0.2592070315480233,"score_spread":0.2491626018637615,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2956512450","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99600095,0.00074705685,0.0013791994,0.00012034841,0.000023588942,0.000034423094,0.0001592127,0.000075994634,0.0014590587],"genre_scores_gemma":[0.99715304,0.00039184987,0.0007098784,0.00003610491,0.000005470404,0.000022668593,0.00018660526,0.000012648562,0.0014816684],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998969,0.000014406114,0.0000072948446,0.000016553116,0.000030800555,0.00003411018],"domain_scores_gemma":[0.99994576,0.000007258684,0.000016180851,0.000004315776,0.000005883522,0.000020551535],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010562901,0.00023994248,0.0002897904,0.00013540775,0.00008130351,0.00022235296,0.00017011166,0.00017422509,0.0008042951],"category_scores_gemma":[0.00008716497,0.000094583935,0.00012597784,0.00009973145,0.00015402873,0.00013992237,0.00014617865,0.00043010933,0.000104524246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015829275,0.00007376005,0.00013643478,0.000030612642,0.000006902552,0.000017173203,0.000006991614,0.00015784414,0.9974522,0.00009820394,0.000084716536,0.0017768868],"study_design_scores_gemma":[0.000048881484,0.0010465834,0.003211347,0.0000037597063,0.000021920712,0.00013034452,0.000015651438,0.0016388424,0.9915835,0.00003461677,0.0022605576,0.0000039264023],"about_ca_topic_score_codex":0.0014551046,"about_ca_topic_score_gemma":0.0029811363,"teacher_disagreement_score":0.0014551046,"about_ca_system_score_codex":0.0003342636,"about_ca_system_score_gemma":0.00043621278,"threshold_uncertainty_score":0.0028933287},"labels":[],"label_agreement":null},{"id":"W2964894061","doi":"10.1016/j.ejmech.2019.111586","title":"Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Carbonic anhydrase; Moiety; Stereochemistry; Enzyme; In vitro; Sulfonamide; Chemical synthesis; Ring (chemistry); Viability assay; Biochemistry; Organic chemistry","score_opus":0.00615513026259965,"score_gpt":0.20468434630133245,"score_spread":0.1985292160387328,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2964894061","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9461074,0.016600851,0.01942461,0.00039097015,0.00023995308,0.00036264485,0.00079888344,0.00035247297,0.015722238],"genre_scores_gemma":[0.9787996,0.007390106,0.0070639085,0.00010700778,0.00003791012,0.00011713879,0.00052942947,0.000020208281,0.0059346925],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999453,0.000008547499,0.0000050349754,0.000008852227,0.000013362526,0.00001894491],"domain_scores_gemma":[0.9999622,0.000004505246,0.000011465512,0.000003727898,0.0000065821623,0.000011562823],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015482787,0.00042404982,0.00039640284,0.0002632692,0.00019635088,0.00018528156,0.00047024043,0.0003709863,0.0015485252],"category_scores_gemma":[0.00010613941,0.00016847243,0.0002224887,0.0002637996,0.00015284074,0.00025369035,0.00023767672,0.0004329506,0.00037838332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004016571,0.00013973619,0.00021241813,0.00048078157,0.00006641556,0.00048398436,0.0001607949,0.0019288865,0.96419144,0.0029563794,0.00083150313,0.028146055],"study_design_scores_gemma":[0.00022296137,0.002313396,0.0012571343,0.000028685394,0.00010179782,0.0004984822,0.000031567113,0.0024666754,0.9635838,0.00028720172,0.029174468,0.00003387875],"about_ca_topic_score_codex":0.00051735435,"about_ca_topic_score_gemma":0.0011453993,"teacher_disagreement_score":0.0015485252,"about_ca_system_score_codex":0.00032860402,"about_ca_system_score_gemma":0.000271538,"threshold_uncertainty_score":0.005180359},"labels":[],"label_agreement":null},{"id":"W2966101753","doi":"10.1021/acs.joc.9b01305","title":"Inhibitory Evaluation of αPMM/PGM from <i>Pseudomonas aeruginosa</i>: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study","year":2019,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research; National Science Foundation","keywords":"Chemistry; Pseudomonas aeruginosa; Kinetics; Enzyme; Enzyme kinetics; Pseudomonadales; Stereochemistry; Pseudomonadaceae; Biochemistry; Bacteria; Active site","score_opus":0.008165245175857141,"score_gpt":0.21722521189422825,"score_spread":0.2090599667183711,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2966101753","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98916537,0.003923096,0.002945964,0.00010810071,0.000025836911,0.00009119223,0.00081338035,0.000080989485,0.0028460314],"genre_scores_gemma":[0.98708874,0.0042291256,0.0058526695,0.000041338655,0.000013611179,0.00006312975,0.0008930338,0.000026077882,0.0017922639],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999052,0.000018660021,0.000009595084,0.000016189286,0.000030922365,0.000019455456],"domain_scores_gemma":[0.9999393,0.000009888649,0.0000188785,0.0000054464213,0.000015034925,0.000011503297],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014478008,0.0002970562,0.0002162321,0.00010891945,0.00012287899,0.00012620773,0.00028730102,0.00016874606,0.00052539824],"category_scores_gemma":[0.00014813126,0.00008194191,0.0001518706,0.00021658369,0.000102796424,0.0001227393,0.000086117514,0.00031724857,0.0001919976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016854407,0.00009132845,0.00010512333,0.000107796,0.000006171303,0.000047316233,0.000017152632,0.00058739784,0.9960722,0.000074862044,0.000096975295,0.0026252838],"study_design_scores_gemma":[0.000013668999,0.000390337,0.0004520537,0.0000040722425,0.000008211797,0.000042495543,0.000006749733,0.00076733273,0.9968286,0.000008266705,0.0014741634,0.000004067042],"about_ca_topic_score_codex":0.0027488794,"about_ca_topic_score_gemma":0.002584711,"teacher_disagreement_score":0.0027488794,"about_ca_system_score_codex":0.00037569995,"about_ca_system_score_gemma":0.00028187197,"threshold_uncertainty_score":0.0054658055},"labels":[],"label_agreement":null},{"id":"W2967331826","doi":"","title":"Alterations of ROS generation and drug sensitivity in Ras-transformed pancreatic cells","year":2006,"lang":"en","type":"article","venue":"","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Reactive oxygen species; NADPH oxidase; Oxidative stress; Superoxide dismutase; Cell biology; Chemistry; Cell growth; Signal transduction; Protein kinase B; Biology; Biochemistry","score_opus":0.0053267764574685,"score_gpt":0.20284802783257536,"score_spread":0.19752125137510684,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2967331826","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9947444,0.0019903653,0.0010026374,0.000089580135,0.00003490935,0.00003983717,0.0007656823,0.000124439,0.0012082323],"genre_scores_gemma":[0.9937941,0.0011936688,0.0013078693,0.000041932217,0.000009728927,0.00006353078,0.0012584525,0.000014994288,0.0023156807],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997336,0.000047900307,0.000034934463,0.000044761015,0.000093852155,0.000044994784],"domain_scores_gemma":[0.99987555,0.000025919151,0.000028241857,0.00002255979,0.000021506305,0.000026309452],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013221105,0.00036925348,0.0003592262,0.00038721858,0.00016381672,0.00024142078,0.00020063786,0.0003287215,0.0012760971],"category_scores_gemma":[0.00012179922,0.00015716538,0.00032937713,0.00035735354,0.0001430457,0.00017230207,0.00016060553,0.0006030357,0.00028916667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001944427,0.00009648837,0.0003037562,0.00003369974,0.000011257854,0.00007551577,0.000021307578,0.000077401004,0.9977481,0.000043274827,0.00003772576,0.0013569881],"study_design_scores_gemma":[0.000017807251,0.0009897735,0.007171883,0.000004043094,0.000025062247,0.0002755114,0.000031489886,0.0009621104,0.9887162,0.000042137162,0.0017559155,0.000008006129],"about_ca_topic_score_codex":0.00093675434,"about_ca_topic_score_gemma":0.00071856374,"teacher_disagreement_score":0.0012760971,"about_ca_system_score_codex":0.00021854606,"about_ca_system_score_gemma":0.0001554828,"threshold_uncertainty_score":0.004269004},"labels":[],"label_agreement":null},{"id":"W2973027397","doi":"10.1177/2472555219872211","title":"Response to the Article “Enzyme–Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality”","year":2019,"lang":"en","type":"letter","venue":"SLAS DISCOVERY","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Enzyme inhibition; Non-competitive inhibition; Allosteric regulation; Simple (philosophy); Chemistry; Mathematical economics; Computer science; Enzyme; Econometrics; Economics; Biochemistry; Epistemology; Philosophy","score_opus":0.01721396668294211,"score_gpt":0.2932678458098351,"score_spread":0.276053879126893,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2973027397","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00023329821,0.005062237,0.0009862437,0.64718854,0.34379873,0.00008238312,0.0002669534,0.00038515488,0.0019964592],"genre_scores_gemma":[0.0009642692,0.0031167523,0.0009658176,0.8077556,0.16895437,0.000106427135,0.00015534993,0.00016735436,0.017814042],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9945821,0.0010756112,0.0007663182,0.000728396,0.0023353482,0.0005122165],"domain_scores_gemma":[0.9816852,0.008741839,0.0016607001,0.0005815995,0.005612276,0.0017182591],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007325538,0.0022485766,0.0019614915,0.0014032198,0.0026835317,0.0041238843,0.0035634504,0.026568914,0.01783111],"category_scores_gemma":[0.033748865,0.0012786114,0.0021839484,0.001314441,0.0039378717,0.00462731,0.0031238045,0.032272957,0.024487339],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000049353683,0.000022249395,0.000060847546,0.00009669047,0.0000066289977,0.00010234136,0.000024611632,0.000029671955,0.00017254242,0.00054484594,0.99432665,0.004563534],"study_design_scores_gemma":[0.000038628175,0.00007671075,0.00040250906,0.00019497749,0.000014551694,0.00030894481,0.000104105675,0.00015229342,0.00052812556,0.0010506453,0.9970908,0.000037674963],"about_ca_topic_score_codex":0.0027462323,"about_ca_topic_score_gemma":0.0043000146,"teacher_disagreement_score":0.026568914,"about_ca_system_score_codex":0.0031488696,"about_ca_system_score_gemma":0.0034909637,"threshold_uncertainty_score":0.059651017},"labels":[],"label_agreement":null},{"id":"W2982513204","doi":"10.1016/j.ejmech.2019.111811","title":"Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Carbonic anhydrase; Context (archaeology); Combinatorial chemistry; Selectivity; Sulfonamide; Thiazolidine; Stereochemistry; Enzyme; Biochemistry","score_opus":0.009222214127119122,"score_gpt":0.24038856866090275,"score_spread":0.23116635453378362,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2982513204","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.79255223,0.02920221,0.08326642,0.0024706342,0.001082157,0.0007298551,0.0016794882,0.0012004666,0.08781646],"genre_scores_gemma":[0.95914334,0.015161326,0.008233132,0.00033647247,0.00012296677,0.00012429623,0.00055923354,0.000078951605,0.016240425],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987113,0.000020548787,0.000010723986,0.000019967309,0.000029988605,0.00004759936],"domain_scores_gemma":[0.9999459,0.000007943691,0.000010800577,0.000008341654,0.000012448993,0.000014627025],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033011872,0.0007080434,0.0004473645,0.00034184958,0.00030366945,0.00034014013,0.0006473109,0.00041706185,0.004105503],"category_scores_gemma":[0.00021328698,0.0002163905,0.00027017604,0.00039448933,0.000313357,0.00057067076,0.0008504904,0.0010336156,0.0014246989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014746028,0.0011846473,0.000566447,0.0017134852,0.00017246553,0.0021864725,0.00085328845,0.007189695,0.8124825,0.024728892,0.011452124,0.13599527],"study_design_scores_gemma":[0.0005692676,0.0056398734,0.0017219698,0.00017624276,0.00012062198,0.0013423343,0.00022626997,0.005087976,0.846057,0.0037731286,0.13515252,0.00013282648],"about_ca_topic_score_codex":0.000709481,"about_ca_topic_score_gemma":0.0021931033,"teacher_disagreement_score":0.004105503,"about_ca_system_score_codex":0.000363369,"about_ca_system_score_gemma":0.00052000745,"threshold_uncertainty_score":0.013734281},"labels":[],"label_agreement":null},{"id":"W3006170201","doi":"10.1016/j.bioorg.2020.103669","title":"X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX","year":2020,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Deanship of Scientific Research, King Saud University; Ontario Ministry of Research, Innovation and Science; Prince Sattam bin Abdulaziz University; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Adduct; Carbonic anhydrase; Enzyme; In vitro; Stereochemistry; Molecule; Gene isoform; Biochemistry; Organic chemistry; Gene","score_opus":0.006485241198023501,"score_gpt":0.1845495957411744,"score_spread":0.17806435454315092,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3006170201","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9739038,0.0025309871,0.0024124237,0.0012442863,0.0002082948,0.000043408407,0.00265595,0.0003255578,0.016675318],"genre_scores_gemma":[0.9761587,0.0024197728,0.0028099974,0.00021151766,0.000027792565,0.00003175185,0.0043441257,0.00006661509,0.013929773],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985087,0.000013632096,0.000008550198,0.000028396018,0.00005283112,0.000045716904],"domain_scores_gemma":[0.99990344,0.000037465914,0.000015922666,0.0000069503812,0.000014744212,0.00002138085],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018643131,0.00039421115,0.0005121571,0.00021228414,0.00049707625,0.0005531863,0.0013227628,0.0006129602,0.0057162726],"category_scores_gemma":[0.00033416678,0.00027256724,0.00022616876,0.0004026247,0.00029533362,0.00025714224,0.0002399711,0.0016737012,0.00064079376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.006140327,0.0012800323,0.011798628,0.0014905897,0.000501905,0.010038129,0.0017236918,0.035005383,0.83622694,0.020181824,0.029568411,0.046044044],"study_design_scores_gemma":[0.00058920524,0.00062128995,0.02792618,0.00016490123,0.00016452784,0.001995064,0.0008511827,0.04299322,0.8759694,0.00086838234,0.047731854,0.00012471495],"about_ca_topic_score_codex":0.018306594,"about_ca_topic_score_gemma":0.012777321,"teacher_disagreement_score":0.018306594,"about_ca_system_score_codex":0.001550681,"about_ca_system_score_gemma":0.0010147884,"threshold_uncertainty_score":0.03640008},"labels":[],"label_agreement":null},{"id":"W3009202799","doi":"10.1038/s41598-020-60917-3","title":"Author Correction: Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation","year":2020,"lang":"en","type":"erratum","venue":"Scientific Reports","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Beijing Normal University; National Natural Science Foundation of China; Salt Science Research Foundation","keywords":"Bifunctional; Phosphatase; Characterization (materials science); Modulation (music); Kinase; Phosphofructokinase 2; Metal; Chemistry; Computer science; Biochemistry; Enzyme; Materials science; Nanotechnology; Physics","score_opus":0.014247556178774524,"score_gpt":0.25003282630931056,"score_spread":0.23578527013053605,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3009202799","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00069554435,0.001329635,0.002137975,0.028935133,0.96053725,0.000024680681,0.00097628735,0.00041100825,0.0049524433],"genre_scores_gemma":[0.04383166,0.01305773,0.016220875,0.046527155,0.1647462,0.00016623363,0.004930723,0.0021441437,0.70837533],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99789387,0.00019393438,0.0003098631,0.00040744024,0.0010195667,0.00017526712],"domain_scores_gemma":[0.9895281,0.002424457,0.0005209371,0.00085511844,0.0060290713,0.000642306],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017241684,0.0015456311,0.0012385354,0.0022726182,0.0022389148,0.0019445467,0.0023945018,0.004081368,0.026646415],"category_scores_gemma":[0.018990217,0.0006821875,0.000962639,0.0016120716,0.0015441107,0.0014595829,0.0011479312,0.0067212447,0.025072526],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000099173296,0.000019839199,0.00015084787,0.00023560993,0.000018323552,0.0009346175,0.000048032507,0.00010969509,0.0010355819,0.0016027464,0.98252076,0.013224804],"study_design_scores_gemma":[0.000020875703,0.000023419512,0.0006406521,0.00009716593,0.000036734877,0.001160013,0.00006380525,0.00023561352,0.0030621057,0.0011193996,0.99351007,0.000030163505],"about_ca_topic_score_codex":0.007761146,"about_ca_topic_score_gemma":0.010271486,"teacher_disagreement_score":0.026646415,"about_ca_system_score_codex":0.002068729,"about_ca_system_score_gemma":0.0027454318,"threshold_uncertainty_score":0.08914113},"labels":[],"label_agreement":null},{"id":"W3014500359","doi":"10.1097/coc.0000000000000691","title":"A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors","year":2020,"lang":"en","type":"article","venue":"American Journal of Clinical Oncology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Welichem Biotech (Canada); SignalChem (Canada); Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Sanofi; GlaxoSmithKline; Servier; Pfizer; Eli Lilly and Company; Genentech; PTC Therapeutics; American Association for Cancer Research","keywords":"Medicine; Tolerability; Cmax; Discontinuation; Internal medicine; Pharmacokinetics; Nausea; Adverse effect; Dosing; Cohort; Vomiting; Gastroenterology; Response Evaluation Criteria in Solid Tumors; Pharmacology; Phases of clinical research; Toxicity","score_opus":0.027762532162020494,"score_gpt":0.37617253892835273,"score_spread":0.3484100067663322,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3014500359","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99629265,0.0006437175,0.0003833922,0.00022697459,0.000043422802,0.0011288514,0.00046990867,0.000046658697,0.00076421694],"genre_scores_gemma":[0.9912411,0.0010333647,0.0016649993,0.0005319798,0.000075026575,0.0012929409,0.0021589352,0.000020250367,0.0019814027],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99971217,0.00012622548,0.0000117711925,0.0000584966,0.00004051794,0.00005080092],"domain_scores_gemma":[0.99947137,0.00007769427,0.000105947336,0.00004008943,0.000051869883,0.000253103],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00088460505,0.0010554086,0.0011724421,0.0002745879,0.0003584259,0.0005712539,0.00047846185,0.0008766631,0.0023800884],"category_scores_gemma":[0.0005886856,0.00039401592,0.00077138434,0.00027120762,0.0005580442,0.00051710237,0.00021530528,0.0018701999,0.0005428168],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.41730314,0.12184282,0.03008394,0.0014394629,0.0016121258,0.001231744,0.0008731013,0.007067,0.24066879,0.0004775614,0.01034425,0.16705608],"study_design_scores_gemma":[0.23919614,0.7128725,0.031205822,0.00002902722,0.00031077446,0.0009756791,0.00007092891,0.0022407419,0.008685156,0.00014360591,0.0042350115,0.000034683035],"about_ca_topic_score_codex":0.0007587727,"about_ca_topic_score_gemma":0.0021858653,"teacher_disagreement_score":0.0023800884,"about_ca_system_score_codex":0.00065472844,"about_ca_system_score_gemma":0.0015042064,"threshold_uncertainty_score":0.007962227},"labels":[],"label_agreement":null},{"id":"W3016590474","doi":"10.1080/14756366.2020.1751620","title":"Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety","year":2020,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ministero dell’Istruzione, dell’Università e della Ricerca; Università degli Studi di Firenze; Canadian Thoracic Society","keywords":"Chemistry; Dipeptide; Antioxidant; DPPH; Carbonic anhydrase; Moiety; Carbonic Anhydrase I; Enzyme; Stereochemistry; Peptide; Medicinal chemistry; Organic chemistry; Biochemistry","score_opus":0.02415439762431237,"score_gpt":0.2705194995020288,"score_spread":0.24636510187771643,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3016590474","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9901148,0.0038738612,0.0043574083,0.00007515933,0.000034223453,0.000052865467,0.0002603589,0.00004934667,0.001182088],"genre_scores_gemma":[0.99239266,0.0013801473,0.004192567,0.00003607084,0.000011984124,0.000024095825,0.00030858043,0.00000781582,0.0016461014],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995816,0.000004973794,0.000004922289,0.00001131007,0.000012568787,0.000008130061],"domain_scores_gemma":[0.99995136,0.0000064480687,0.000015450245,0.0000044075546,0.000008523432,0.000013673858],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000085836466,0.00021637937,0.00018336502,0.00008681796,0.00007083036,0.00011879397,0.00021510092,0.00021942907,0.0005426022],"category_scores_gemma":[0.000073938405,0.00008594605,0.00013366119,0.00007880541,0.00011223421,0.00011444714,0.00006338556,0.00026655308,0.00016058837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000032081418,0.000009728242,0.000021291009,0.00003053623,0.0000021938208,0.000031061656,0.0000042121496,0.000044955097,0.999092,0.000024073495,0.000011016144,0.000696905],"study_design_scores_gemma":[0.000018941553,0.0004525565,0.00072809134,0.0000028350823,0.00001139575,0.00016162166,0.0000037941031,0.00021404284,0.99694234,0.000011927369,0.0014487057,0.000003737355],"about_ca_topic_score_codex":0.00024455576,"about_ca_topic_score_gemma":0.00045034155,"teacher_disagreement_score":0.0005426022,"about_ca_system_score_codex":0.00013995946,"about_ca_system_score_gemma":0.00011892306,"threshold_uncertainty_score":0.0018151999},"labels":[],"label_agreement":null},{"id":"W3037181298","doi":"10.3390/cancers12071723","title":"The Expression of Carbonic Anhydrases II, IX and XII in Brain Tumors","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Carcinogenesis; Cancer research; Brain tumor; Cancer; Glioma; Hypoxia (environmental); Medicine; Brain cancer; Internal medicine; Bioinformatics; Neuroscience; Biology; Chemistry; Pathology","score_opus":0.016077582280201945,"score_gpt":0.28299500483312257,"score_spread":0.2669174225529206,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3037181298","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00031795676,0.99811965,0.00016487546,0.0001512245,0.00012658015,0.000003677776,0.000035176094,0.000008587551,0.0010722898],"genre_scores_gemma":[0.0012831426,0.9976672,0.00016029191,0.000096952426,0.000082454564,0.0000054179523,0.000059023627,0.000001859461,0.0006435653],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999068,0.000012051534,0.000014794462,0.00001954751,0.000036504236,0.000010347246],"domain_scores_gemma":[0.999899,0.000038985832,0.000017321037,0.0000030669116,0.00003185471,0.000009855875],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023469479,0.0004973808,0.000690632,0.0015056165,0.00014030741,0.000606806,0.00039366735,0.00053004274,0.002063956],"category_scores_gemma":[0.00036573433,0.0001708573,0.0003334666,0.001407613,0.00019575362,0.0005605112,0.00033722582,0.00084721606,0.0013106383],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000102514576,0.000045561123,0.00030308875,0.017204396,0.000118637276,0.0002895427,0.000049853148,0.0004021844,0.0078082685,0.0027606061,0.02336082,0.9475546],"study_design_scores_gemma":[0.000014669858,0.00011149947,0.0012548668,0.0018154565,0.00017952926,0.0020053193,0.000032378422,0.00013075028,0.0031531227,0.0010673277,0.9902152,0.000019827165],"about_ca_topic_score_codex":0.000960988,"about_ca_topic_score_gemma":0.001569643,"teacher_disagreement_score":0.002063956,"about_ca_system_score_codex":0.00041286068,"about_ca_system_score_gemma":0.0006888089,"threshold_uncertainty_score":0.0069046617},"labels":[],"label_agreement":null},{"id":"W3048029751","doi":"10.3390/ijms21165697","title":"Interplay between Carbonic Anhydrases and Metallothioneins: Structural Control of Metalation","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario","keywords":"Metalation; Chemistry; Biochemistry; Carbonic anhydrase; Enzyme; Biology; Stereochemistry","score_opus":0.02096129970558748,"score_gpt":0.34305154914519753,"score_spread":0.32209024943961007,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3048029751","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00020920696,0.99879396,0.0000975853,0.00012680964,0.0000902014,0.0000017578743,0.000009256534,0.0000049123446,0.00066627446],"genre_scores_gemma":[0.0011803232,0.99787164,0.00012691674,0.00007947027,0.000099580095,0.0000034776988,0.00002249183,0.0000010765295,0.0006150479],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99989676,0.000014693848,0.000014609229,0.000021255371,0.000040178278,0.000012414605],"domain_scores_gemma":[0.99986994,0.000054970424,0.000021249225,0.0000040428044,0.00003390423,0.00001598762],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029912256,0.0006054167,0.0008832129,0.0013714149,0.0001726392,0.0007012723,0.0006155109,0.0007732976,0.001856679],"category_scores_gemma":[0.000338497,0.00021857859,0.0002488671,0.0015806938,0.00030898134,0.00093397475,0.0005197617,0.0008833143,0.0014318252],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000107502136,0.00005191102,0.0002616088,0.018147243,0.00009620443,0.00031502132,0.00006944343,0.00041274048,0.0071687615,0.0056401514,0.016700653,0.95102865],"study_design_scores_gemma":[0.00001872156,0.00008859609,0.0010424894,0.0015729947,0.00008689914,0.001726765,0.000053364965,0.00010615664,0.0015614347,0.002038715,0.9916882,0.00001587727],"about_ca_topic_score_codex":0.00064034533,"about_ca_topic_score_gemma":0.0010984328,"teacher_disagreement_score":0.001856679,"about_ca_system_score_codex":0.00044377695,"about_ca_system_score_gemma":0.00064910535,"threshold_uncertainty_score":0.006211221},"labels":[],"label_agreement":null},{"id":"W3048734311","doi":"10.1007/112_2020_18","title":"Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"Reviews of physiology, biochemistry and pharmacology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Prostate cancer; Cancer; Cancer research; Metastasis; Intracellular pH; Cancer cell; Cotransporter; Extracellular; Biology; Internal medicine; Chemistry; Medicine; Cell biology; Sodium","score_opus":0.012725803673144319,"score_gpt":0.2825460945509143,"score_spread":0.26982029087777,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3048734311","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0023732944,0.9908572,0.0016887684,0.0023295493,0.0007501562,0.0000072509756,0.000021324895,0.000031532025,0.001941005],"genre_scores_gemma":[0.021480585,0.9731223,0.00096851104,0.00065591343,0.0013127255,0.000010508054,0.00002928303,0.0000069495604,0.0024132046],"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","domain_scores_codex":[0.99983597,0.000029655488,0.000013080192,0.000026979287,0.00006623376,0.000027943901],"domain_scores_gemma":[0.9998141,0.00006770604,0.000030307634,0.000010399945,0.000046196656,0.00003130954],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00079729117,0.00064655935,0.00077498914,0.0006386142,0.00024325884,0.0009691429,0.0006437405,0.0009074883,0.0010542605],"category_scores_gemma":[0.000459678,0.00024619178,0.00031299752,0.000750265,0.000980791,0.0010360794,0.0005275028,0.002204175,0.00052909227],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011206049,0.00037032424,0.0013090603,0.005218357,0.00016272417,0.0008181158,0.0001534448,0.0027242792,0.14665848,0.03283098,0.03297428,0.7756592],"study_design_scores_gemma":[0.00015027472,0.0010678857,0.0075456807,0.00069377304,0.00019464361,0.0025133698,0.00018601013,0.0013622991,0.05409688,0.021415118,0.91068745,0.000086707325],"about_ca_topic_score_codex":0.00060534803,"about_ca_topic_score_gemma":0.00075827434,"teacher_disagreement_score":0.0010542605,"about_ca_system_score_codex":0.00072461716,"about_ca_system_score_gemma":0.0006223536,"threshold_uncertainty_score":0.0052574873},"labels":[],"label_agreement":null},{"id":"W3048890836","doi":"10.1039/d0sc02676j","title":"Mechanistic insight into hydroxamate transfer reaction mimicking the inhibition of zinc-containing enzymes","year":2020,"lang":"en","type":"article","venue":"Chemical Science","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Kootenay Association for Science & Technology","funders":"Daegu Gyeongbuk Institute of Science and Technology; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; City University of Hong Kong","keywords":"Zinc; Chemistry; Enzyme; Combinatorial chemistry; Metal; Biochemistry; Organic chemistry","score_opus":0.01494998000275604,"score_gpt":0.23266426660703576,"score_spread":0.21771428660427972,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3048890836","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9061401,0.0056599164,0.068518154,0.0018421696,0.000330134,0.00031018324,0.0003956617,0.00035607818,0.016447594],"genre_scores_gemma":[0.98828715,0.0018171876,0.008122871,0.000105578896,0.00002100353,0.0000489979,0.00010496379,0.0000092831715,0.0014830541],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986815,0.000032740365,0.000009889464,0.000027287257,0.0000310919,0.000030773426],"domain_scores_gemma":[0.99994934,0.00001553822,0.000014548099,0.0000055822643,0.000006402455,0.000008536959],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037665205,0.00046048735,0.0002402348,0.00009474372,0.00020231647,0.00037008146,0.00050471874,0.0005080011,0.0015645198],"category_scores_gemma":[0.00022941877,0.00011660092,0.00027842913,0.000061862615,0.0003824417,0.0005207902,0.00031491165,0.0006352545,0.00025805068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003335699,0.0001755096,0.00029469092,0.0004323278,0.000023607503,0.00074331614,0.00012910155,0.0029811761,0.9746241,0.014458329,0.00033281962,0.0054715057],"study_design_scores_gemma":[0.000097866,0.0013711167,0.00052035047,0.000022285885,0.000026627804,0.00084831414,0.00009229089,0.009554653,0.9748439,0.0024257023,0.010175863,0.000021022162],"about_ca_topic_score_codex":0.00038215343,"about_ca_topic_score_gemma":0.0003902505,"teacher_disagreement_score":0.0015645198,"about_ca_system_score_codex":0.00039230986,"about_ca_system_score_gemma":0.0004214433,"threshold_uncertainty_score":0.005233884},"labels":[],"label_agreement":null},{"id":"W3083093525","doi":"10.1158/1538-7445.am2020-ct161","title":"Abstract CT161: Phase I clinical trials of SLC-0111, a novel inhibitor of carbonic anhydrase IX, in patients with advanced solid tumors","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SignalChem (Canada); Princess Margaret Cancer Centre; Welichem Biotech (Canada); Spinal Cord Injury BC","funders":"","keywords":"Tolerability; Medicine; Response Evaluation Criteria in Solid Tumors; Nausea; Adverse effect; Pharmacokinetics; Internal medicine; Oncology; Pharmacology; Vomiting; Cancer; Discontinuation; Clinical trial; Phases of clinical research","score_opus":0.1466887722011047,"score_gpt":0.4786759782495269,"score_spread":0.3319872060484222,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3083093525","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98591655,0.0036575105,0.000719235,0.00077782676,0.00016768028,0.0036390426,0.0024395115,0.00017791265,0.0025047057],"genre_scores_gemma":[0.976785,0.0029194881,0.002939074,0.0011062971,0.00013995319,0.004794826,0.0053842757,0.000054341275,0.005876713],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9996244,0.0001619134,0.000021882026,0.00007035837,0.000045563975,0.00007588787],"domain_scores_gemma":[0.99936455,0.00006726848,0.000155447,0.00004463036,0.00004860824,0.00031943966],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014947341,0.0015576932,0.0015299545,0.0004379197,0.00045124782,0.0009848098,0.00088544376,0.0012172092,0.0036473884],"category_scores_gemma":[0.0007751819,0.0004857143,0.0011203843,0.00047959934,0.00093665975,0.00072664925,0.00035571898,0.0031253893,0.0008630333],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.56854725,0.058042355,0.009083512,0.0020258084,0.0015952212,0.0007134679,0.0006321243,0.006840502,0.21590523,0.0010396055,0.013682112,0.121892855],"study_design_scores_gemma":[0.3778678,0.58505666,0.012464203,0.00008713951,0.0003669144,0.0006857276,0.00010632731,0.0023509064,0.012934666,0.00039041223,0.007637296,0.000051928135],"about_ca_topic_score_codex":0.0012765032,"about_ca_topic_score_gemma":0.0046161604,"teacher_disagreement_score":0.0036473884,"about_ca_system_score_codex":0.0011828848,"about_ca_system_score_gemma":0.0021546574,"threshold_uncertainty_score":0.012201726},"labels":[],"label_agreement":null},{"id":"W3105364541","doi":"10.3389/fcell.2020.602668","title":"Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Occupational Cancer Research Centre; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; BC Cancer Foundation; Five Colleges","keywords":"Tumor microenvironment; Transporter; Biochemistry; Tumor progression; Tumor hypoxia; Biology; Amino acid; Cell biology; Chemistry; Cancer research; Tumor cells; Medicine","score_opus":0.0070559950540809695,"score_gpt":0.21068462037877705,"score_spread":0.20362862532469608,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3105364541","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00018388995,0.9983234,0.00018390661,0.00019294067,0.00011430014,0.000003187698,0.00001466576,0.000007701069,0.0009760246],"genre_scores_gemma":[0.0008732991,0.9980788,0.00019771628,0.000119438984,0.00008236674,0.0000059681233,0.00002799318,0.0000014762734,0.00061298325],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998952,0.000014448136,0.000014933976,0.000020972873,0.000039746534,0.00001470755],"domain_scores_gemma":[0.9998791,0.000041315237,0.000019416026,0.0000041582593,0.00003838665,0.000017609571],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038039027,0.00076657796,0.0010006402,0.0015092295,0.00021414895,0.00076515117,0.0006309403,0.0008635869,0.0015594021],"category_scores_gemma":[0.0003308134,0.00029279303,0.00032184867,0.0015896972,0.00037087826,0.0010302769,0.00061199645,0.0013143772,0.0014913178],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011658299,0.00006582675,0.0002334393,0.01768531,0.00011287655,0.00029808749,0.00005795776,0.0006030567,0.009828419,0.006849679,0.02728242,0.9368664],"study_design_scores_gemma":[0.000017128634,0.00011043843,0.0009287767,0.0013257719,0.00010087094,0.0010584773,0.000032755746,0.00018151748,0.0023271805,0.0016306393,0.99226636,0.00001993702],"about_ca_topic_score_codex":0.000992634,"about_ca_topic_score_gemma":0.0018875289,"teacher_disagreement_score":0.0015594021,"about_ca_system_score_codex":0.00066486915,"about_ca_system_score_gemma":0.0008521069,"threshold_uncertainty_score":0.0052167177},"labels":[],"label_agreement":null},{"id":"W3121002723","doi":"10.1021/acs.jpca.0c09768","title":"Nature of S–N Bonding in Sulfonamides and Related Compounds: Insights into π-Bonding Contributions from Sulfur K-Edge X-ray Absorption Spectroscopy","year":2021,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry A","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"X-ray absorption spectroscopy; Sulfur; Chemistry; Reactivity (psychology); Molecule; Computational chemistry; Density functional theory; Chemical bond; Spectroscopy; Absorption (acoustics); Absorption spectroscopy; Crystallography; Chemical physics; Organic chemistry; Materials science; Physics","score_opus":0.0043574027730335215,"score_gpt":0.24348943957794247,"score_spread":0.23913203680490897,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3121002723","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98556674,0.0018631638,0.0070487475,0.0002304722,0.000029571225,0.000016217144,0.000078622696,0.000055709264,0.005110739],"genre_scores_gemma":[0.9965486,0.0009984444,0.0018955241,0.00003444508,0.0000059556496,0.000009446362,0.000055130076,0.00000764364,0.0004449215],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994123,0.00001313094,0.0000029216358,0.000008935654,0.000021893136,0.000011826556],"domain_scores_gemma":[0.99988997,0.00006240083,0.000021725358,0.000008105478,0.000011039776,0.000006709764],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024173703,0.0003204806,0.00018650635,0.00023015359,0.00028509577,0.0002036789,0.00032303802,0.00031005105,0.0016512397],"category_scores_gemma":[0.000219258,0.00013589062,0.00018305318,0.00012975141,0.00040697522,0.0004087215,0.0002117006,0.00041750917,0.000114232345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003709892,0.00018281718,0.005301346,0.00081037177,0.00005197163,0.0007263021,0.0005030369,0.024740271,0.9229292,0.021589568,0.00054550637,0.022248637],"study_design_scores_gemma":[0.0000854069,0.0020963615,0.025704032,0.00013372501,0.00009427844,0.0007879073,0.001239804,0.24778284,0.69045615,0.023767173,0.0077562793,0.00009603528],"about_ca_topic_score_codex":0.000559162,"about_ca_topic_score_gemma":0.0008383771,"teacher_disagreement_score":0.0016512397,"about_ca_system_score_codex":0.0002261638,"about_ca_system_score_gemma":0.00013541964,"threshold_uncertainty_score":0.00552392},"labels":[],"label_agreement":null},{"id":"W3121138262","doi":"10.18433/jpps31349","title":"Cell Cycle Arrest and Apoptosis Induction by a New 2,4-Dinitrobenzenesulfonamide Derivative In Acute Leukemia Cells","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Universidade Federal de Santa Catarina; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Jurkat cells; Apoptosis; K562 cells; Cytotoxic T cell; Survivin; Cell biology; Programmed cell death; Cell cycle; Cell cycle checkpoint; Flow cytometry; Biology; Chemistry; Cancer research; Immunology; T cell; Biochemistry; Immune system; In vitro","score_opus":0.02615275931369373,"score_gpt":0.3284409097241682,"score_spread":0.30228815041047447,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3121138262","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99589044,0.0024727453,0.00078423426,0.000030592677,0.000010215698,0.000018501822,0.00009393259,0.000025558777,0.00067380874],"genre_scores_gemma":[0.9957586,0.0019469674,0.0010720916,0.000020900156,0.0000072557423,0.000024564431,0.00025116245,0.0000049539785,0.00091341644],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999348,0.000014297382,0.000008055211,0.000011261791,0.000019226281,0.000012385076],"domain_scores_gemma":[0.99993503,0.000013423787,0.00002396253,0.00000582405,0.000011024524,0.0000107565265],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000957527,0.00026580165,0.00018167672,0.00017960931,0.000113780334,0.00011275135,0.00013247809,0.000122971,0.0007477126],"category_scores_gemma":[0.00007330278,0.000051873405,0.00014848085,0.00012459229,0.00010901911,0.00010704342,0.00009395944,0.00017564137,0.00016400614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018010655,0.000042144395,0.00038285783,0.0000815502,0.000004351495,0.00004801946,0.000021230391,0.00020637308,0.9962047,0.00006012774,0.00002983257,0.002738694],"study_design_scores_gemma":[0.00002936294,0.0015790843,0.004307787,0.000010027798,0.000016065815,0.00022136122,0.000022496306,0.0007257428,0.99068767,0.000029795518,0.0023666036,0.0000039849497],"about_ca_topic_score_codex":0.00049601705,"about_ca_topic_score_gemma":0.0007852434,"teacher_disagreement_score":0.0007477126,"about_ca_system_score_codex":0.000186831,"about_ca_system_score_gemma":0.0001735468,"threshold_uncertainty_score":0.0025013685},"labels":[],"label_agreement":null},{"id":"W3126558437","doi":"10.1021/acs.jmedchem.0c02077","title":"Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SignalChem (Canada)","funders":"National Cancer Institute","keywords":"Chemistry; Acetazolamide; Carbonic anhydrase; Cytotoxicity; Cell culture; Growth inhibition; Extracellular; Cancer research; Cell growth; Carbonic anhydrase II; Biochemistry; Carbonic anhydrase inhibitor; Pharmacology; Enzyme; Internal medicine; In vitro; Biology; Medicine","score_opus":0.011592691953903101,"score_gpt":0.2717755059293136,"score_spread":0.2601828139754105,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3126558437","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99364895,0.0024087364,0.0015783266,0.00022372197,0.000023428907,0.0000253097,0.00013278126,0.00004491708,0.0019136558],"genre_scores_gemma":[0.99702114,0.0007101925,0.0012565007,0.00005515901,0.000007994188,0.000012439588,0.00022907078,0.0000057542434,0.0007018047],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999287,0.000016020947,0.000005377698,0.000008930907,0.000028757679,0.000012248874],"domain_scores_gemma":[0.99993813,0.000014610126,0.000015587024,0.0000066038524,0.000012910703,0.000012126413],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115443574,0.00014707765,0.00019163785,0.000051297404,0.00008390918,0.00010816513,0.00019876992,0.00017336552,0.0008744252],"category_scores_gemma":[0.0001403243,0.0000429106,0.00011381353,0.00005421213,0.000114624294,0.00007643063,0.0000846836,0.0001991385,0.00018278424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000057462483,0.000011898608,0.00012659669,0.000026796952,0.0000029755286,0.00002645974,0.0000039772535,0.00005011747,0.9984842,0.00005945317,0.000038872833,0.0011111218],"study_design_scores_gemma":[0.000018388879,0.00038641947,0.0031504626,0.0000033698223,0.00000958014,0.00027165224,0.0000075909993,0.0008403228,0.9932862,0.000019620014,0.002003853,0.0000025626382],"about_ca_topic_score_codex":0.0008179921,"about_ca_topic_score_gemma":0.001180404,"teacher_disagreement_score":0.0008744252,"about_ca_system_score_codex":0.00022360859,"about_ca_system_score_gemma":0.000204909,"threshold_uncertainty_score":0.0029252768},"labels":[],"label_agreement":null},{"id":"W3139515002","doi":"10.3390/ijms22062999","title":"Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Health and Medical Research Council","keywords":"Chemistry; IC50; Amiloride; Selectivity; Biochemistry; Sodium; In vitro","score_opus":0.014054044271500934,"score_gpt":0.2553430390757227,"score_spread":0.24128899480422178,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3139515002","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9816638,0.0040521617,0.007159513,0.00017719559,0.000047958772,0.00029859168,0.0012232822,0.00022454544,0.0051529645],"genre_scores_gemma":[0.9776228,0.0037798518,0.00997294,0.00018548302,0.000023425111,0.0001748581,0.002702351,0.0000464767,0.0054917927],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976903,0.000037794172,0.000021625929,0.000051599818,0.00007674483,0.00004321881],"domain_scores_gemma":[0.9999125,0.000015970654,0.0000169239,0.000009414314,0.000019856627,0.0000252575],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023077919,0.0004855187,0.00061036367,0.00035899557,0.00013073339,0.00028569848,0.00040008288,0.0003645944,0.0019180877],"category_scores_gemma":[0.00021186093,0.00020298018,0.00036239775,0.00037610796,0.00013693825,0.00021398424,0.0002783495,0.0006188511,0.0007227586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025693767,0.00015620005,0.00018819574,0.00009343896,0.000023804501,0.0000938733,0.000020254261,0.0005039315,0.99188954,0.000088028006,0.000127361,0.0065585277],"study_design_scores_gemma":[0.000185322,0.0039878935,0.0026864707,0.000019789146,0.00011989824,0.00063172664,0.000041749994,0.0026175224,0.9824974,0.0000615109,0.0071261376,0.000024595784],"about_ca_topic_score_codex":0.00040878073,"about_ca_topic_score_gemma":0.0011615836,"teacher_disagreement_score":0.0019180877,"about_ca_system_score_codex":0.00027644687,"about_ca_system_score_gemma":0.0002116027,"threshold_uncertainty_score":0.006416619},"labels":[],"label_agreement":null},{"id":"W3143768062","doi":"10.1039/d1cc01231b","title":"<sup>19</sup>F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes","year":2021,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; National Defense Science and Engineering Graduate; Achievement Rewards for College Scientists Foundation","keywords":"Pharmacophore; Chemistry; Fluorine-19 NMR; Carbonic anhydrase II; Carbonic anhydrase; Ligand (biochemistry); Metal; Stereochemistry; Metalloprotein; Nuclear magnetic resonance spectroscopy; Combinatorial chemistry; Enzyme; Biochemistry; Organic chemistry; Receptor","score_opus":0.04809531515459895,"score_gpt":0.31960921059960895,"score_spread":0.27151389544501,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3143768062","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9459791,0.0030800109,0.04519653,0.0005902163,0.000049568087,0.000099262994,0.00088910025,0.00031726013,0.0037988613],"genre_scores_gemma":[0.93948185,0.0018385802,0.055039458,0.00023315902,0.00002937555,0.00006879073,0.0014120619,0.00005753341,0.0018393482],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998845,0.000031321448,0.0000066294197,0.00002096927,0.000035348894,0.00002110964],"domain_scores_gemma":[0.99983466,0.000054602177,0.000039613613,0.00001154274,0.000031556203,0.00002803574],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023337848,0.0002963267,0.00025892214,0.0001250498,0.00014280433,0.00015703432,0.0002538021,0.00022316535,0.001179493],"category_scores_gemma":[0.0003536024,0.00008556033,0.000098424636,0.00014990615,0.00021444052,0.00017639126,0.00013433788,0.00028195124,0.00035779245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021010086,0.000025206824,0.0002974068,0.00003629897,0.0000057880675,0.000053828844,0.000011747297,0.00027809164,0.99124134,0.00012888557,0.0002133061,0.0074980175],"study_design_scores_gemma":[0.00001686745,0.00020662264,0.0007843173,0.0000026953323,0.0000070590745,0.00031603873,0.000009932378,0.0004937764,0.9947903,0.000033867535,0.0033334997,0.0000050394065],"about_ca_topic_score_codex":0.00049931556,"about_ca_topic_score_gemma":0.00070037326,"teacher_disagreement_score":0.001179493,"about_ca_system_score_codex":0.00014068521,"about_ca_system_score_gemma":0.00015753087,"threshold_uncertainty_score":0.003945768},"labels":[],"label_agreement":null},{"id":"W3160884771","doi":"10.1002/ddr.21831","title":"New isolate from <scp><i>Salvinia molesta</i></scp> with antioxidant and urease inhibitory activity","year":2021,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor","funders":"","keywords":"Chemistry; Urease; Antioxidant; DPPH; Biochemistry; Stereochemistry; Chromatography; Organic chemistry; Enzyme","score_opus":0.017700269233465266,"score_gpt":0.27155617130310417,"score_spread":0.25385590206963893,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3160884771","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9906838,0.0029683698,0.0015605348,0.0002637053,0.00004822923,0.000093586415,0.0012119233,0.0001166862,0.0030531662],"genre_scores_gemma":[0.98799324,0.0017671388,0.003972903,0.00017816195,0.00009046935,0.000038976712,0.0033623236,0.000024286877,0.0025724953],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999542,0.0000056886265,0.0000058196365,0.000010565754,0.0000142354265,0.000009438027],"domain_scores_gemma":[0.99993134,0.000010106432,0.000017190161,0.000007851405,0.000018197165,0.000015296815],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000056553294,0.0005435994,0.0003019955,0.00046681956,0.00026869847,0.00024041631,0.000149744,0.00023755124,0.0008584551],"category_scores_gemma":[0.00015964075,0.00008744661,0.00033337603,0.0005238344,0.00014853649,0.0001897317,0.00020601311,0.00024494034,0.00033353717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011954551,0.000070550086,0.001259726,0.00016664913,0.000020073438,0.000747353,0.00006281393,0.00012853206,0.9855085,0.00006582071,0.00024967708,0.011600647],"study_design_scores_gemma":[0.0001365203,0.0034684658,0.11732624,0.00013205466,0.000274294,0.011749912,0.0004341636,0.0019747051,0.81282,0.00035715758,0.051276166,0.000050251183],"about_ca_topic_score_codex":0.0013465213,"about_ca_topic_score_gemma":0.0012687426,"teacher_disagreement_score":0.0013465213,"about_ca_system_score_codex":0.000118500386,"about_ca_system_score_gemma":0.00034861057,"threshold_uncertainty_score":0.0028718114},"labels":[],"label_agreement":null},{"id":"W3164402145","doi":"10.1016/j.urolonc.2021.04.011","title":"Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma","year":2021,"lang":"en","type":"article","venue":"Urologic Oncology Seminars and Original Investigations","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency; Decipher Biosciences (Canada); University of British Columbia","funders":"","keywords":"Gene silencing; Cancer research; Biology; Bladder cancer; Pathology; Urothelial Cell; Cell growth; Cystectomy; Urothelium; Cell culture; Cancer; Small interfering RNA; Medicine; Transfection; Internal medicine; Urinary bladder; Gene","score_opus":0.023740734080079595,"score_gpt":0.2991380258558943,"score_spread":0.2753972917758147,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3164402145","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.84788954,0.1256151,0.0050108847,0.0018700894,0.0003210918,0.00032289344,0.0003248755,0.00010274178,0.018542781],"genre_scores_gemma":[0.9653908,0.027291067,0.0016189013,0.00019835068,0.0001264511,0.000057616537,0.00026187112,0.000019749628,0.0050351494],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998179,0.000059451337,0.000010696776,0.000018163115,0.000054306343,0.00003936954],"domain_scores_gemma":[0.9999089,0.000026430916,0.000009884305,0.000007978169,0.000027570883,0.000019238661],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074271025,0.00028608498,0.0004635407,0.00024614154,0.00023648054,0.0005545095,0.00034870097,0.00041730484,0.0016182222],"category_scores_gemma":[0.0003056364,0.00008857794,0.00030169333,0.00028372914,0.00025862953,0.00022759475,0.00014980597,0.00044756,0.00026662502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0053421427,0.00066899805,0.0038271786,0.0006812674,0.00013317143,0.0007274129,0.00011377121,0.0015895402,0.87955177,0.0017835482,0.0011414522,0.104439735],"study_design_scores_gemma":[0.0005416647,0.011897582,0.009251533,0.000052147876,0.00031831567,0.0011909825,0.000116191586,0.0020843693,0.93730325,0.00043943292,0.03678863,0.000015882015],"about_ca_topic_score_codex":0.001330683,"about_ca_topic_score_gemma":0.0015557626,"teacher_disagreement_score":0.0016182222,"about_ca_system_score_codex":0.0007364341,"about_ca_system_score_gemma":0.00056327845,"threshold_uncertainty_score":0.0054135323},"labels":[],"label_agreement":null},{"id":"W3164750745","doi":"10.1080/14756366.2021.1929202","title":"Anion inhibition studies of the α-carbonic anhydrases from <i>Neisseria gonorrhoeae</i>","year":2021,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Chemistry; Sulfamide; Carbonic anhydrase; Thiocyanate; Bicarbonate; Inorganic chemistry; Formate; Perrhenate; Perchlorate; Medicinal chemistry; Nuclear chemistry; Organic chemistry; Enzyme; Catalysis","score_opus":0.01445889046641854,"score_gpt":0.25911822953819813,"score_spread":0.24465933907177959,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3164750745","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98800313,0.005712871,0.0022178325,0.00014542785,0.000051349634,0.0000858549,0.00064129924,0.000046964185,0.003095325],"genre_scores_gemma":[0.98742294,0.0040845065,0.0041424474,0.000081792954,0.00003340693,0.000050337287,0.0013856392,0.000019855985,0.0027790659],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996505,0.000094898955,0.00004892719,0.000046207995,0.00010371606,0.00005574025],"domain_scores_gemma":[0.99980706,0.000059709393,0.00003762518,0.000011629766,0.000058589587,0.000025316374],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003594374,0.00043853023,0.0004171905,0.00011297144,0.00014886161,0.00017542312,0.00029243148,0.00032439813,0.0007755964],"category_scores_gemma":[0.00030221383,0.00015845193,0.00043428925,0.00019170894,0.00014021741,0.00020404764,0.00016114011,0.00038105572,0.00023083706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025120523,0.000054041804,0.00026841837,0.00010587474,0.000017608218,0.0000440666,0.000038608607,0.00017545065,0.9971637,0.000035619716,0.00005883669,0.0017865673],"study_design_scores_gemma":[0.00003489626,0.0010386338,0.0046959664,0.000010724205,0.000030691463,0.00018462849,0.000033165485,0.00088658533,0.98960716,0.000019506968,0.0034456386,0.000012434897],"about_ca_topic_score_codex":0.0053157015,"about_ca_topic_score_gemma":0.0038529818,"teacher_disagreement_score":0.0053157015,"about_ca_system_score_codex":0.00025232814,"about_ca_system_score_gemma":0.00021783376,"threshold_uncertainty_score":0.010569513},"labels":[],"label_agreement":null},{"id":"W3165295814","doi":"10.1016/j.bmcl.2021.128147","title":"Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Carbonic anhydrase; In vitro; Enzyme; Cytotoxicity; Cell culture; Cancer cell; Biochemistry; Pharmacology; Cancer; Stereochemistry; Cancer research; Internal medicine; Biology","score_opus":0.00480229126075558,"score_gpt":0.19912559108835437,"score_spread":0.1943232998275988,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3165295814","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9796102,0.007933582,0.0031780906,0.00024265058,0.00011173998,0.00008313358,0.00029784575,0.00021804059,0.008324693],"genre_scores_gemma":[0.98985565,0.0043836585,0.0015938767,0.00006741182,0.000032188535,0.00003962438,0.000390703,0.000019862673,0.0036170844],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999281,0.000013712952,0.0000050028875,0.0000090065805,0.00002203146,0.000022052565],"domain_scores_gemma":[0.9999577,0.000007813128,0.000009995241,0.000004772773,0.000005917242,0.000013710481],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017815473,0.00032182506,0.00034886008,0.00026762593,0.0001599717,0.00022149367,0.00042142623,0.00031407183,0.0009457231],"category_scores_gemma":[0.00013337434,0.00014261695,0.0001411955,0.0002548103,0.0001626686,0.0002076062,0.00022071725,0.00045148534,0.00023987709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007406036,0.00012051544,0.000285215,0.00015452072,0.000041972635,0.00024478487,0.00009179328,0.0017417867,0.97038984,0.0017012347,0.0008797263,0.023607923],"study_design_scores_gemma":[0.0002215391,0.002424638,0.0016170637,0.000010627043,0.00007371363,0.0003763791,0.000019104758,0.0023333179,0.97777253,0.000118164775,0.015017316,0.000015566193],"about_ca_topic_score_codex":0.0009012324,"about_ca_topic_score_gemma":0.0020911999,"teacher_disagreement_score":0.0009457231,"about_ca_system_score_codex":0.00036345996,"about_ca_system_score_gemma":0.00019925949,"threshold_uncertainty_score":0.003163755},"labels":[],"label_agreement":null},{"id":"W3165528810","doi":"10.1007/s12035-021-02437-3","title":"The Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- and Chemotherapy and Reduces Tumor Growth","year":2021,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Chemotherapy; Cancer research; Radiation therapy; Drug; Intracellular; Brain tumor; Carbonic anhydrase; Adjuvant; Growth inhibition; Cell growth; Medicine; Biology; Enzyme; Pharmacology; Pathology; Internal medicine; Biochemistry","score_opus":0.0023102982612518775,"score_gpt":0.19095559128765607,"score_spread":0.1886452930264042,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3165528810","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9890069,0.0033138255,0.0019378877,0.00037398725,0.000099849894,0.000044173237,0.0005369713,0.00044408083,0.0042424067],"genre_scores_gemma":[0.99253696,0.0024870727,0.0010786802,0.00012389956,0.000018275934,0.000019804635,0.0007197346,0.000041275143,0.0029742727],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998796,0.000010539043,0.0000075745797,0.000012232186,0.00004035207,0.000049594953],"domain_scores_gemma":[0.9999373,0.000008842841,0.000013285139,0.000008276984,0.000009790094,0.000022547247],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008175154,0.00041078022,0.00041522435,0.0005427307,0.00017926557,0.00028394186,0.00023838619,0.0003616066,0.0010782938],"category_scores_gemma":[0.0001118033,0.00018226805,0.00023336514,0.00035259253,0.00022395723,0.00018198723,0.00018325035,0.00064422505,0.0003682841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003241495,0.00015593109,0.00023046111,0.000044990287,0.00002726312,0.00007184362,0.000014947736,0.0003783942,0.98701197,0.00022957752,0.0006352431,0.010875068],"study_design_scores_gemma":[0.00003776785,0.0007230608,0.0025920167,0.000003883091,0.00002215577,0.00019038282,0.000014220182,0.00069347734,0.9918304,0.000088411696,0.0037973921,0.000006960335],"about_ca_topic_score_codex":0.0034996935,"about_ca_topic_score_gemma":0.0064071347,"teacher_disagreement_score":0.0034996935,"about_ca_system_score_codex":0.0004099917,"about_ca_system_score_gemma":0.0004293744,"threshold_uncertainty_score":0.006958604},"labels":[],"label_agreement":null},{"id":"W3194401934","doi":"10.1093/protein/gzab021","title":"Engineering stable carbonic anhydrases for CO2 capture: a critical review","year":2021,"lang":"en","type":"review","venue":"Protein Engineering Design and Selection","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Computational biology; Phage display; Protein engineering; Drug discovery; Structural similarity; Similarity (geometry); Computer science; Protein design; Chemistry; Protein structure; Biology; Combinatorial chemistry; Biochemistry; Artificial intelligence; Enzyme","score_opus":0.02784295521283906,"score_gpt":0.27300077260762184,"score_spread":0.2451578173947828,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3194401934","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00017595913,0.9984174,0.0002495116,0.00015954112,0.00016487935,0.000007844318,0.000026489453,0.000009549007,0.0007888461],"genre_scores_gemma":[0.0005948845,0.99857044,0.00026489433,0.00010276698,0.000069670496,0.000009814827,0.00003226886,0.0000018617835,0.00035346014],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998103,0.000021998401,0.000028330867,0.00004119692,0.000074417716,0.000023801353],"domain_scores_gemma":[0.9996842,0.00015507112,0.000042648015,0.000008951077,0.00008593128,0.00002324981],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00068979495,0.0012491649,0.001409957,0.0021045,0.00025480933,0.00094977213,0.0009047519,0.0009710791,0.003220737],"category_scores_gemma":[0.0006934445,0.0004531194,0.0006174478,0.0028466322,0.00037241093,0.0014201785,0.00066925545,0.0013971884,0.0020982646],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009182957,0.00013202768,0.00015165556,0.05237273,0.00018126075,0.00022592777,0.00008215942,0.001085076,0.005489912,0.007440882,0.03056766,0.9021789],"study_design_scores_gemma":[0.00001704306,0.00015152925,0.00042503144,0.004242529,0.00016507399,0.00042467713,0.000045233766,0.00018289355,0.0016457674,0.0014440034,0.9912299,0.000026301315],"about_ca_topic_score_codex":0.0010479685,"about_ca_topic_score_gemma":0.0013328075,"teacher_disagreement_score":0.003220737,"about_ca_system_score_codex":0.0005580561,"about_ca_system_score_gemma":0.0010685073,"threshold_uncertainty_score":0.010774434},"labels":[],"label_agreement":null},{"id":"W3195000164","doi":"10.1126/sciadv.abj0364","title":"Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency; Saskatchewan Cancer Agency; Vancouver General Hospital; Pancreas Centre (Canada); University of Saskatchewan","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Intracellular; Cell biology; Chemistry; Hypoxia (environmental); Cancer research; Homeostasis; Biochemistry; Biology; Oxygen","score_opus":0.011096839560005725,"score_gpt":0.27298984547210414,"score_spread":0.2618930059120984,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3195000164","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96880215,0.001561778,0.021681517,0.00029306777,0.000064151376,0.000109282424,0.0028640039,0.00077717204,0.003846949],"genre_scores_gemma":[0.98646796,0.0008000256,0.0063809734,0.00010635675,0.000008099197,0.00006049395,0.0019656844,0.00007608945,0.004134354],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998747,0.0000110327455,0.00000894541,0.00003941893,0.00004361464,0.00002227208],"domain_scores_gemma":[0.9999063,0.000020689085,0.00003178066,0.0000077995655,0.00000868121,0.000024631725],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015918321,0.00048785107,0.00035567116,0.0002991146,0.0001975906,0.00030043413,0.00022658943,0.00037083015,0.0015627012],"category_scores_gemma":[0.000114629205,0.000120259116,0.00025770796,0.0001617141,0.00026223907,0.000113720664,0.0002497985,0.00045312828,0.00028752847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000051620907,0.0000127970325,0.0002917356,0.000030038877,0.0000073082165,0.00012666974,0.000008158263,0.00018064177,0.9976921,0.00016692841,0.00005560289,0.0013764478],"study_design_scores_gemma":[0.000027841706,0.0002756492,0.006304188,0.000010103302,0.00005065405,0.0007970008,0.00004529173,0.0039050174,0.9821859,0.0001661158,0.006220447,0.000011732348],"about_ca_topic_score_codex":0.0009869087,"about_ca_topic_score_gemma":0.0020323156,"teacher_disagreement_score":0.0015627012,"about_ca_system_score_codex":0.00039829963,"about_ca_system_score_gemma":0.00032854886,"threshold_uncertainty_score":0.005227804},"labels":[],"label_agreement":null},{"id":"W3195535935","doi":"10.1016/j.ejmech.2021.113793","title":"Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Neuropathic pain; Chemistry; Pharmacology; Cisplatin; Oxaliplatin; Doxorubicin; Peripheral neuropathy; Carbonic anhydrase; Chemotherapy; Cancer; Enzyme; Medicine; Biochemistry; Colorectal cancer; Internal medicine","score_opus":0.018252087921603148,"score_gpt":0.24818157003259864,"score_spread":0.22992948211099548,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3195535935","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99309736,0.0011614707,0.0018263805,0.00007690588,0.00011603287,0.00005402667,0.00034660712,0.00025261837,0.0030685277],"genre_scores_gemma":[0.9958126,0.0005226494,0.00072107936,0.000025431178,0.0000079711535,0.000018257397,0.00023510722,0.000018766408,0.0026380478],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989605,0.000011287547,0.000009335786,0.0000182216,0.000022541715,0.00004259185],"domain_scores_gemma":[0.999944,0.000008664655,0.000011729876,0.000007337835,0.000010823054,0.000017537439],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007982983,0.0003538342,0.00032226995,0.0002843829,0.00012543508,0.0002221205,0.0003002105,0.00028355958,0.0019021211],"category_scores_gemma":[0.00009279583,0.0001010611,0.00013889799,0.00025419737,0.00017564975,0.00016978868,0.00011933576,0.00058259594,0.0002966116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00076007063,0.000103791,0.00012361874,0.00005610243,0.000014460193,0.00012612338,0.00001569702,0.00022261284,0.99340594,0.00031959207,0.00014984865,0.00470211],"study_design_scores_gemma":[0.000034833323,0.00050237606,0.0005872887,0.0000022591105,0.000018660214,0.000109333705,0.000007840484,0.00033408575,0.99722147,0.000028531087,0.001149839,0.0000034484858],"about_ca_topic_score_codex":0.00131416,"about_ca_topic_score_gemma":0.0024755145,"teacher_disagreement_score":0.0019021211,"about_ca_system_score_codex":0.00026744636,"about_ca_system_score_gemma":0.0004360429,"threshold_uncertainty_score":0.0063632727},"labels":[],"label_agreement":null},{"id":"W3206004995","doi":"10.1002/aoc.6464","title":"Antibacterial metal complexes of <i>o</i>‐sulfamoylbenzoic acid: Synthesis, characterization, and DFT study","year":2021,"lang":"en","type":"article","venue":"Applied Organometallic Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"King Khalid University","keywords":"Chemistry; HOMO/LUMO; Ligand (biochemistry); Reactivity (psychology); Ligand field theory; Metal; Octahedron; Crystallography; Molecular orbital; Transition metal; Natural bond orbital; Ionic bonding; Octahedral molecular geometry; Metal ions in aqueous solution; Chromophore; Magnetic susceptibility; Stereochemistry; Ion; Density functional theory; Computational chemistry; Molecule; Crystal structure; Photochemistry; Organic chemistry; Catalysis","score_opus":0.0066977201011989215,"score_gpt":0.20318980882903276,"score_spread":0.19649208872783383,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3206004995","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9880073,0.003363446,0.0043207086,0.00017170225,0.000029128552,0.000029344581,0.00018939178,0.00007710738,0.0038117685],"genre_scores_gemma":[0.99463403,0.0009482227,0.0031772903,0.000036694775,0.0000069459907,0.000018447545,0.00016963479,0.000010473411,0.000998067],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994946,0.0000102913655,0.0000029707132,0.0000071389136,0.000016833174,0.00001337236],"domain_scores_gemma":[0.9999777,0.000004028572,0.0000060525763,0.0000021443057,0.000004984752,0.0000049900314],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000068667396,0.00015858434,0.000213921,0.00011387681,0.00014183241,0.0001825183,0.0002617188,0.00021129365,0.0009359283],"category_scores_gemma":[0.000094082265,0.00007409546,0.00009885477,0.00012882457,0.000100701705,0.00010293041,0.00016710913,0.0001970356,0.00018794145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00033976234,0.000065149434,0.00066597515,0.00053658383,0.000021620335,0.00025368683,0.00007568863,0.004255878,0.98198295,0.002301058,0.0006292579,0.008872393],"study_design_scores_gemma":[0.00006304592,0.0013092161,0.0029837943,0.0000334204,0.000039151633,0.0004079124,0.00013782622,0.02649968,0.94856143,0.0005172406,0.01941898,0.000028234603],"about_ca_topic_score_codex":0.00045113257,"about_ca_topic_score_gemma":0.0008641136,"teacher_disagreement_score":0.0009359283,"about_ca_system_score_codex":0.00018445098,"about_ca_system_score_gemma":0.00011054453,"threshold_uncertainty_score":0.003131032},"labels":[],"label_agreement":null},{"id":"W3207292544","doi":"10.3389/fphar.2021.746925","title":"Editorial: Metalloenzymes: Potential Drug Targets","year":2021,"lang":"en","type":"editorial","venue":"Frontiers in Pharmacology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Drug; Pharmacology; Medicine; Drug target; Chemistry","score_opus":0.0030403027561234455,"score_gpt":0.24689207511745265,"score_spread":0.2438517723613292,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3207292544","genre_codex":"editorial","genre_gemma":"editorial","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"editorial","genre_consensus":"editorial","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000035471636,0.0046129893,0.0001228892,0.026776634,0.9658279,0.000026786096,0.00009713552,0.0000735384,0.0024267016],"genre_scores_gemma":[0.0005203466,0.005065582,0.00012976487,0.020548763,0.9517218,0.000031469866,0.00008234092,0.000044035183,0.021855816],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99718106,0.00044562694,0.00029372066,0.00038280478,0.0014550333,0.00024176153],"domain_scores_gemma":[0.9918156,0.0020309503,0.0006422065,0.00021939681,0.003351145,0.0019407333],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004321285,0.0036496383,0.0025659453,0.0026464073,0.0023787776,0.005323252,0.0029071856,0.009864414,0.03133676],"category_scores_gemma":[0.012061635,0.00093089417,0.0022064154,0.00092791574,0.0016318603,0.0037895613,0.0014343774,0.013096732,0.027657298],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000042147083,0.000008078784,0.0000101394935,0.00011397938,0.00000818168,0.00007094366,0.0000037134218,0.000017064938,0.0000643196,0.00018179405,0.99594903,0.0035305698],"study_design_scores_gemma":[0.000070038186,0.000030907704,0.00013424284,0.00019435838,0.00003052703,0.0002584797,0.000016762084,0.00008843791,0.00016454808,0.0010644794,0.9979329,0.00001428003],"about_ca_topic_score_codex":0.0009255225,"about_ca_topic_score_gemma":0.002746278,"teacher_disagreement_score":0.03133676,"about_ca_system_score_codex":0.0023813862,"about_ca_system_score_gemma":0.0024457008,"threshold_uncertainty_score":0.104831874},"labels":[],"label_agreement":null},{"id":"W3208707312","doi":"10.1007/978-3-030-79511-5_12","title":"Targeting Carbonic Anhydrase IX in Tumor Imaging and Theranostic Cancer Therapy","year":2021,"lang":"en","type":"book-chapter","venue":"Progress in drug research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Cancer research; Tumor hypoxia; Hypoxia (environmental); Tumor microenvironment; Chemistry; Metastasis; Cancer cell; Intracellular; Cancer; Biology; Biochemistry; Medicine; Internal medicine; Tumor cells; Oxygen","score_opus":0.027711801662271607,"score_gpt":0.34243754054672976,"score_spread":0.31472573888445815,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3208707312","genre_codex":"other","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0064916923,0.46049836,0.04228473,0.00336825,0.0052515557,0.000096309275,0.00047839308,0.0007566633,0.480774],"genre_scores_gemma":[0.017672187,0.18609631,0.01302956,0.0009571591,0.00080524344,0.000066674285,0.00026370064,0.00020129148,0.7809078],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99993086,0.0000053767967,0.0000018584266,0.000012133011,0.00004298647,0.000006696001],"domain_scores_gemma":[0.9999752,0.000009969921,0.000002212792,0.0000019136642,0.000006884283,0.0000037704735],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011042528,0.0005831915,0.00037813938,0.00048209526,0.00022142104,0.00083659834,0.00049871794,0.0005428109,0.014562405],"category_scores_gemma":[0.0001089637,0.0001975861,0.00020125118,0.00055348297,0.00023870575,0.0009709145,0.00043805875,0.00091474614,0.007118412],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000085709056,0.0000879299,0.00005615783,0.0011845595,0.000017195745,0.00030254194,0.00013142149,0.0015055727,0.12891428,0.075267546,0.18243374,0.6100133],"study_design_scores_gemma":[0.0000049831297,0.000029166373,0.000095061,0.00010760148,0.000008231618,0.0005030578,0.000015468548,0.0007078317,0.017219532,0.0059245564,0.97537667,0.000007769821],"about_ca_topic_score_codex":0.0008664152,"about_ca_topic_score_gemma":0.0023993044,"teacher_disagreement_score":0.014562405,"about_ca_system_score_codex":0.0006506354,"about_ca_system_score_gemma":0.00035628863,"threshold_uncertainty_score":0.04871607},"labels":[],"label_agreement":null},{"id":"W3210569579","doi":"10.1007/978-3-030-79511-5_8","title":"Carbonic Anhydrase IX Interactome and the Regulation of Cancer Progression","year":2021,"lang":"en","type":"book-chapter","venue":"Progress in drug research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Interactome; Carbonic anhydrase; Cancer; Cancer cell; Biology; Biochemistry; Cancer therapy; Chemistry; Computational biology; Cancer research; Cell biology; Enzyme; Gene; Genetics","score_opus":0.028171392674506922,"score_gpt":0.3742464896606507,"score_spread":0.3460750969861438,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3210569579","genre_codex":"review","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.025360137,0.78980875,0.013178206,0.0075068064,0.0018226663,0.00004614603,0.000626394,0.00027519694,0.16137567],"genre_scores_gemma":[0.12530267,0.49545184,0.009287339,0.001842894,0.0019016032,0.00010824747,0.00082207174,0.0001131514,0.36517018],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999199,0.000008534185,0.0000025778468,0.000015724876,0.000042559815,0.0000107096475],"domain_scores_gemma":[0.9999647,0.000017369983,0.000005041863,0.0000018821801,0.000005963284,0.0000050579342],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013820874,0.0003889016,0.0003295455,0.0005114899,0.0002267204,0.0010242703,0.00045919165,0.00046789457,0.005006278],"category_scores_gemma":[0.00012385561,0.00013940618,0.0001836861,0.00067521934,0.00028243553,0.0005537917,0.00035335033,0.0007942993,0.0015309091],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004851245,0.00013032524,0.00085279864,0.0011812565,0.00008769186,0.0008222821,0.00030797406,0.0023712427,0.28584954,0.15287068,0.083445996,0.47159508],"study_design_scores_gemma":[0.00002475307,0.000098695804,0.003926743,0.00017529145,0.00004527587,0.0013149247,0.00007352378,0.0020622998,0.040510587,0.023100445,0.9286446,0.000022856504],"about_ca_topic_score_codex":0.0016641533,"about_ca_topic_score_gemma":0.003762224,"teacher_disagreement_score":0.005006278,"about_ca_system_score_codex":0.0008845693,"about_ca_system_score_gemma":0.0003627472,"threshold_uncertainty_score":0.016747713},"labels":[],"label_agreement":null},{"id":"W3215962778","doi":"10.1080/19420862.2021.1997072","title":"Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX","year":2021,"lang":"en","type":"article","venue":"mAbs","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; National Research Council Canada","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Hydrogen–deuterium exchange; Isothermal titration calorimetry; Monoclonal antibody; Enzyme; Biophysics; Conjugate; Biochemistry; Extracellular; Epitope; Antibody; Mass spectrometry; Chromatography; Biology","score_opus":0.013581175493916908,"score_gpt":0.24501783172713013,"score_spread":0.23143665623321322,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3215962778","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99328786,0.0005049582,0.0041549588,0.000112895665,0.000017024715,0.000009821007,0.0004165359,0.00008567339,0.0014103072],"genre_scores_gemma":[0.9938771,0.00030667795,0.0033232614,0.000138038,0.000007720206,0.00001728081,0.0006084601,0.00002262407,0.0016988893],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998801,0.000013480741,0.000004130218,0.000029920426,0.000040181552,0.000032132095],"domain_scores_gemma":[0.9999155,0.000023431592,0.000018638124,0.0000060261727,0.00001674967,0.000019675947],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367964,0.000386537,0.00018228003,0.00023597578,0.00015883359,0.00018009839,0.00023997841,0.00045460943,0.0010202976],"category_scores_gemma":[0.00017166024,0.00012566062,0.00015919947,0.00014059027,0.00022772499,0.00013035,0.00019616469,0.0005069207,0.000238423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009826163,0.000012492863,0.0003597514,0.000015601967,0.000008166263,0.000032696746,0.000012315094,0.00008470916,0.998497,0.000040961506,0.00007000183,0.0007679133],"study_design_scores_gemma":[0.000008841392,0.00011061225,0.0052281776,0.0000017432128,0.000012914004,0.00018612393,0.000022289749,0.0027763173,0.99079037,0.000033599048,0.0008218088,0.000007287845],"about_ca_topic_score_codex":0.0007268175,"about_ca_topic_score_gemma":0.0006018924,"teacher_disagreement_score":0.0010202976,"about_ca_system_score_codex":0.00024240358,"about_ca_system_score_gemma":0.00009852521,"threshold_uncertainty_score":0.00341326},"labels":[],"label_agreement":null},{"id":"W3217779163","doi":"10.1080/19420862.2021.1999194","title":"Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX","year":2021,"lang":"en","type":"article","venue":"mAbs","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Terry Fox Research Institute; National Research Council Canada","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Research Institute","keywords":"Monoclonal antibody; Extracellular; Antibody; Carbonic anhydrase; Cancer cell; Enzyme; Tumor microenvironment; Cancer; Biochemistry; Biology; Chemistry; Immunology","score_opus":0.00858304745555132,"score_gpt":0.23032794380991511,"score_spread":0.22174489635436379,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3217779163","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93971705,0.006514433,0.045881215,0.00058043463,0.00010622989,0.00035711756,0.0014064237,0.00015150236,0.0052856505],"genre_scores_gemma":[0.9495911,0.0038998905,0.03387703,0.00023609916,0.000058579757,0.00019806129,0.0053072236,0.000057355628,0.006774829],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991715,0.000011054584,0.0000084677,0.000017644246,0.000028750188,0.000016945165],"domain_scores_gemma":[0.9999008,0.000019487941,0.000016192922,0.000010355102,0.000030553496,0.000022635446],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019847334,0.00026026584,0.00010944835,0.00023255973,0.00011000016,0.00018864269,0.00015411791,0.00020582188,0.00057801435],"category_scores_gemma":[0.00034560575,0.000099023564,0.00015130977,0.000121195735,0.00009060761,0.00011000321,0.00011181418,0.00035483582,0.00038924636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000011714638,0.000013481653,0.00010961704,0.000017681727,0.0000028394854,0.000023098673,0.000008205667,0.000058515794,0.997792,0.00008275456,0.000050391747,0.001829791],"study_design_scores_gemma":[0.000028068998,0.00018182823,0.0061309906,0.000007779938,0.000021678296,0.00039854014,0.0000128489255,0.00089436537,0.980456,0.00008259896,0.011780768,0.0000045991333],"about_ca_topic_score_codex":0.0010065027,"about_ca_topic_score_gemma":0.0014119335,"teacher_disagreement_score":0.0010065027,"about_ca_system_score_codex":0.0003159621,"about_ca_system_score_gemma":0.00028168768,"threshold_uncertainty_score":0.0022925138},"labels":[],"label_agreement":null},{"id":"W413596735","doi":"10.1096/fasebj.21.6.a1281-b","title":"Direct Fusion of the CAII Carbonic Anhydrase to the AE1 Cl‐/HCO3‐ Exchanger","year":2007,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Carbonic anhydrase II; Intracellular pH; Chemistry; Carbonic anhydrase; Bicarbonate; Cytosol; Extracellular; Gene isoform; Biochemistry; Biophysics; Transporter; Enzyme; Biology; Gene","score_opus":0.010027374037889534,"score_gpt":0.2342322139229953,"score_spread":0.22420483988510578,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W413596735","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97425234,0.0018438711,0.016937086,0.0004556434,0.00017650987,0.00019942295,0.0025419155,0.00017170032,0.0034215096],"genre_scores_gemma":[0.970974,0.0013941699,0.011762501,0.00016804946,0.000038666378,0.00013125628,0.0049603065,0.00008521677,0.010485668],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997185,0.000038408863,0.000035190067,0.00007049638,0.00008044676,0.000056971792],"domain_scores_gemma":[0.9998191,0.00004130031,0.000053198717,0.000027742633,0.00002806564,0.000030702617],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035615196,0.0004712788,0.00046255416,0.00020156382,0.0002601031,0.0005368533,0.00050593837,0.00080330437,0.0015833925],"category_scores_gemma":[0.0002780731,0.0002634653,0.0004489436,0.00040865506,0.00026221533,0.00025081178,0.000464221,0.0009510566,0.00089854613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000074000964,0.000013234393,0.00010323843,0.000039725546,0.0000076229635,0.00004186972,0.00002237302,0.000093722345,0.99856985,0.00030452374,0.000100703226,0.0006291209],"study_design_scores_gemma":[0.000024556244,0.000076791155,0.0020865165,0.000007715382,0.00002468209,0.00024715977,0.0000257607,0.0024233959,0.983809,0.000062240426,0.011204088,0.000008219666],"about_ca_topic_score_codex":0.0013795694,"about_ca_topic_score_gemma":0.0008968547,"teacher_disagreement_score":0.0015833925,"about_ca_system_score_codex":0.0008059838,"about_ca_system_score_gemma":0.00028143963,"threshold_uncertainty_score":0.0058478713},"labels":[],"label_agreement":null},{"id":"W4200077534","doi":"10.1080/14756366.2021.1994559","title":"Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen <i>malassezia pachydermatis</i>","year":2021,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Fondazione Cassa di Risparmio di Firenze; Ente Cassa di Risparmio di Firenze","keywords":"Microbiology; Biology; Malassezia; Antifungal drug; Virulence; Heterologous expression; Fungus; Candida albicans; Recombinant DNA; Biochemistry; Gene","score_opus":0.00592953314296141,"score_gpt":0.2008406035671567,"score_spread":0.19491107042419528,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4200077534","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9677326,0.0048998957,0.01846256,0.00068931276,0.00013983244,0.00020734301,0.0039860304,0.00020825399,0.0036741751],"genre_scores_gemma":[0.9533327,0.00329793,0.025571158,0.00013452378,0.000056709072,0.00007766802,0.010836166,0.000081672515,0.0066115097],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998235,0.0000206942,0.000021982041,0.00004153876,0.000060951672,0.00003148761],"domain_scores_gemma":[0.9998454,0.00003041389,0.000043827004,0.000020940992,0.000034058565,0.000025322079],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020153383,0.00037803935,0.00030751928,0.00017416844,0.00016223194,0.00035713435,0.00026351254,0.00030916077,0.00053262536],"category_scores_gemma":[0.00031653768,0.00012027151,0.0004478342,0.00036483534,0.00021456486,0.00025733598,0.00022181787,0.0005483755,0.0005147515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000024454042,0.000015234074,0.0002381613,0.000054583787,0.0000051251127,0.00004946839,0.000021112914,0.00008400144,0.9982262,0.00011602407,0.00005234075,0.0011132968],"study_design_scores_gemma":[0.0000108408385,0.00012444198,0.0068580736,0.000011222521,0.000028335104,0.0006775764,0.000050788505,0.00093630684,0.9771237,0.000063934574,0.014105712,0.000009162709],"about_ca_topic_score_codex":0.00277978,"about_ca_topic_score_gemma":0.002072253,"teacher_disagreement_score":0.00277978,"about_ca_system_score_codex":0.0003941134,"about_ca_system_score_gemma":0.00031778862,"threshold_uncertainty_score":0.0055271983},"labels":[],"label_agreement":null},{"id":"W4200156776","doi":"10.1080/14756366.2021.1991336","title":"Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of <i>Neisseria gonorrhoeae</i>","year":2021,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca; Purdue University","keywords":"Acetazolamide; Neisseria gonorrhoeae; Chemistry; Carbonic anhydrase; Potency; Pharmacology; Microbiology; Enzyme; Internal medicine; In vitro; Biochemistry; Medicine; Biology","score_opus":0.010222138603189608,"score_gpt":0.24962633084561953,"score_spread":0.23940419224242993,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4200156776","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5642866,0.2721016,0.014506547,0.010255846,0.0046254196,0.0017856167,0.0033019108,0.0006386199,0.12849781],"genre_scores_gemma":[0.8884444,0.068595804,0.007556783,0.003369261,0.00055148976,0.00016108801,0.0019832437,0.000060113594,0.029277777],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986494,0.000021492464,0.000009469089,0.000013615683,0.000052342395,0.000038213817],"domain_scores_gemma":[0.9999083,0.000009332384,0.000027366981,0.000006354769,0.000027243836,0.000021236227],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024074476,0.0002952179,0.00030894805,0.00027230722,0.00020237338,0.0003777094,0.00030646767,0.00043851644,0.0055099274],"category_scores_gemma":[0.00035038413,0.00010647912,0.0003259485,0.00017037152,0.00017307581,0.00018957276,0.00026550508,0.0006636739,0.0009848801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0036524248,0.0007912075,0.0025199868,0.0019436462,0.00021270542,0.0038455236,0.00029592484,0.00081560796,0.5021436,0.0044600065,0.03391717,0.4454022],"study_design_scores_gemma":[0.003024401,0.013348466,0.011284548,0.00079265685,0.00046796963,0.011115747,0.0003763499,0.0023810568,0.4035029,0.0020879286,0.55153376,0.00008416912],"about_ca_topic_score_codex":0.0016298044,"about_ca_topic_score_gemma":0.0069362964,"teacher_disagreement_score":0.0055099274,"about_ca_system_score_codex":0.00032704507,"about_ca_system_score_gemma":0.00048225958,"threshold_uncertainty_score":0.018432498},"labels":[],"label_agreement":null},{"id":"W4200422017","doi":"10.1080/14756366.2021.1988945","title":"Dithiocarbamates effectively inhibit the α-carbonic anhydrase from <i>Neisseria gonorrhoeae</i>","year":2021,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Neisseria gonorrhoeae; Carbonic anhydrase; Chemistry; Antimicrobial; Enzyme; Combinatorial chemistry; Microbiology; Zinc; Biochemistry; Stereochemistry; Organic chemistry; Biology","score_opus":0.005273958466694184,"score_gpt":0.21662874217051342,"score_spread":0.21135478370381924,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4200422017","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9802548,0.010932919,0.0030305048,0.00015052294,0.000058993326,0.00016120658,0.00028946868,0.00010009716,0.0050214436],"genre_scores_gemma":[0.9898114,0.003868953,0.0037997207,0.00007130947,0.0000152392095,0.000034021683,0.00027925684,0.00001083196,0.0021092917],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992704,0.000011090787,0.0000066224347,0.000014633474,0.000023366638,0.000017200025],"domain_scores_gemma":[0.9999347,0.000018309487,0.000015856938,0.000004474114,0.00001180812,0.000014924627],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000872013,0.00029963147,0.00023590337,0.000099780445,0.000108758584,0.000119346914,0.00014622102,0.00020064361,0.0010400187],"category_scores_gemma":[0.00013519874,0.000074303054,0.00015358144,0.00008921831,0.00013514423,0.00008338735,0.00008476229,0.00026189303,0.00014940072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009075701,0.000022604028,0.0001268966,0.00009118175,0.0000075911385,0.00003820752,0.000009463484,0.000113449714,0.9957913,0.00004030103,0.000045030025,0.0036231638],"study_design_scores_gemma":[0.000019654148,0.000736662,0.0013600696,0.0000041944904,0.000015879934,0.00013147872,0.000009615056,0.0002737483,0.99426115,0.000015799767,0.0031670148,0.0000047782264],"about_ca_topic_score_codex":0.0014786413,"about_ca_topic_score_gemma":0.0050898073,"teacher_disagreement_score":0.0014786413,"about_ca_system_score_codex":0.00020077545,"about_ca_system_score_gemma":0.0002546828,"threshold_uncertainty_score":0.0034791827},"labels":[],"label_agreement":null},{"id":"W4200490776","doi":"10.1142/9789811228698_0028","title":"Temperature Stability of Poly-[hemoglobinsuperoxide dismutase-catalase-carbonic anhydrase] in the Form of a Solution or in the Lyophilized Form During Storage at –80°C, 4°C, 25°C and 37°C or Pasteurization at 70°C","year":2021,"lang":"en","type":"book-chapter","venue":"Regenerative medicine, artificial cells and nanomedicine","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Carbonic anhydrase; Catalase; Chemistry; Enzyme; Biochemistry","score_opus":0.019700645119252607,"score_gpt":0.23085775031804628,"score_spread":0.2111571051987937,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4200490776","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9172379,0.03119241,0.022950996,0.00025422635,0.00029355608,0.000035133577,0.0012190257,0.00036974426,0.02644713],"genre_scores_gemma":[0.94025064,0.0076295245,0.0037327139,0.000070780916,0.000046071815,0.00002591023,0.0015029102,0.00017872588,0.046562716],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995303,0.000003975556,0.0000025513632,0.000015672846,0.000018841849,0.0000059974573],"domain_scores_gemma":[0.9999378,0.000016579894,0.000010989159,0.000008637911,0.000021036285,0.000005069537],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012855435,0.00014682038,0.00010423897,0.000117661984,0.00007511256,0.0001855119,0.0002357291,0.00012483941,0.0017455486],"category_scores_gemma":[0.00015102739,0.00005688952,0.00014662367,0.0001684639,0.00012321516,0.00021609031,0.000077978846,0.0002544578,0.00049002666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013058988,0.000013845789,0.00014849228,0.000047661106,0.0000050153053,0.000030428113,0.000022820357,0.00022726026,0.984892,0.0002625702,0.0002654194,0.013953898],"study_design_scores_gemma":[0.0000033552901,0.00017697838,0.0027481634,0.000010347842,0.000016473032,0.00013915231,0.0000087645285,0.00073445064,0.9888461,0.00014690042,0.007161544,0.000007711955],"about_ca_topic_score_codex":0.0005075541,"about_ca_topic_score_gemma":0.00041631507,"teacher_disagreement_score":0.0017455486,"about_ca_system_score_codex":0.00021326443,"about_ca_system_score_gemma":0.00011860099,"threshold_uncertainty_score":0.005839467},"labels":[],"label_agreement":null},{"id":"W4205606019","doi":"10.1158/2326-6074.tumimm21-p038","title":"Abstract P038: Identification and functional evaluation of monoclonal antibodies specifically targeting human Carbonic Anhydrase IX","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Spinal Cord Injury BC; National Research Council Canada","funders":"","keywords":"Tumor hypoxia; Monoclonal antibody; Cancer research; Hypoxia (environmental); Carbonic anhydrase; Biology; Antibody; Chemistry; Biochemistry; Radiation therapy; Enzyme; Medicine; Immunology; Internal medicine","score_opus":0.09562450883257141,"score_gpt":0.38601229145727783,"score_spread":0.29038778262470644,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4205606019","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98797846,0.0023639791,0.006176404,0.00017407723,0.000053461958,0.0002674192,0.0005191794,0.0001289336,0.002338065],"genre_scores_gemma":[0.9882655,0.0011638732,0.0058444724,0.000144511,0.000033793323,0.00019856417,0.0021019033,0.000029642162,0.0022177116],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996948,0.000058844835,0.00002735446,0.000060589686,0.00006449523,0.0000939239],"domain_scores_gemma":[0.99985456,0.0000330591,0.000029028073,0.000010823501,0.000037098027,0.00003538116],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037822913,0.0007567591,0.00023477203,0.0003805473,0.00015560102,0.0002594438,0.00045528964,0.0006662729,0.0012929856],"category_scores_gemma":[0.00028361718,0.00018456834,0.0003733556,0.00020756322,0.00014649385,0.00018080678,0.00017486868,0.0005993156,0.00045653174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015529229,0.00013467601,0.00018306384,0.000033211316,0.000008393211,0.000040895207,0.000007839241,0.00016095738,0.99706537,0.000050666906,0.00009417902,0.002065434],"study_design_scores_gemma":[0.00014912132,0.0029458632,0.004025957,0.000011898906,0.000072516275,0.00051662716,0.000015364854,0.0022855913,0.98596096,0.000047183912,0.003962259,0.000006609571],"about_ca_topic_score_codex":0.00091265375,"about_ca_topic_score_gemma":0.0006827029,"teacher_disagreement_score":0.0012929856,"about_ca_system_score_codex":0.00051960093,"about_ca_system_score_gemma":0.00019762828,"threshold_uncertainty_score":0.0043254495},"labels":[],"label_agreement":null},{"id":"W4206633401","doi":"10.1080/14756366.2021.2012174","title":"Coumarins effectively inhibit bacterial α-carbonic anhydrases","year":2022,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca; Purdue Institute for Drug Discovery; Purdue University","keywords":"Coumarin; Chemistry; Prodrug; Neisseria gonorrhoeae; Enzyme; Biochemistry; Carboxylic acid; Carbonic anhydrase; Ketone; Bacteria; Stereochemistry; Ring (chemistry); Microbiology; Biology; Organic chemistry","score_opus":0.0065472820888349305,"score_gpt":0.221965565705456,"score_spread":0.21541828361662108,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4206633401","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97426766,0.009925191,0.003116379,0.00027637449,0.000116006806,0.000059190785,0.0010793083,0.00029180248,0.010868123],"genre_scores_gemma":[0.98900956,0.00266504,0.0008985679,0.00006361164,0.00002337001,0.000019201916,0.0011391513,0.000016767017,0.006164734],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994135,0.000007982179,0.000003755439,0.000009937252,0.000016011925,0.000020925352],"domain_scores_gemma":[0.99993694,0.000018663586,0.000011439512,0.000006347913,0.0000100192165,0.000016561264],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000060760587,0.00027171438,0.00019924504,0.00022529408,0.00009694469,0.00013947439,0.00014193308,0.00021862403,0.0036891496],"category_scores_gemma":[0.00016566194,0.00008089008,0.00011265893,0.00021871619,0.00014021568,0.00012234702,0.00009589727,0.00039560554,0.00064695545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003654804,0.000062092535,0.00014153798,0.000098435565,0.0000106254765,0.000046832018,0.00001370445,0.0002672084,0.99188614,0.00018573579,0.0002168419,0.0067053013],"study_design_scores_gemma":[0.000050546456,0.0010121076,0.0022423877,0.00000796675,0.000021178801,0.00019302864,0.000016042466,0.0005393751,0.98997086,0.000050691666,0.005890389,0.000005502226],"about_ca_topic_score_codex":0.0014204747,"about_ca_topic_score_gemma":0.0026857734,"teacher_disagreement_score":0.0036891496,"about_ca_system_score_codex":0.00018263493,"about_ca_system_score_gemma":0.00022223934,"threshold_uncertainty_score":0.01234138},"labels":[],"label_agreement":null},{"id":"W4211082021","doi":"10.1080/14756366.2022.2038592","title":"Inhibition studies of bacterial α-carbonic anhydrases with phenols","year":2022,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca; Purdue Institute for Drug Discovery; Purdue University","keywords":"Phenols; Chemistry; Phenol; Neisseria gonorrhoeae; Amino acid; Bacteria; Hydroxymethyl; Nitrofuran; Biochemistry; Organic chemistry; Microbiology; Biology","score_opus":0.014912433670777816,"score_gpt":0.2549995909042851,"score_spread":0.24008715723350726,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4211082021","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.986692,0.008772208,0.002022666,0.00008070135,0.000024327699,0.000045601177,0.0002918574,0.000027164708,0.0020434964],"genre_scores_gemma":[0.9893273,0.0058320807,0.0024070381,0.000029085802,0.00001642043,0.000027523445,0.00038906277,0.000008232524,0.0019633227],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998122,0.00004868402,0.00001403095,0.000023629396,0.00005606581,0.000045489294],"domain_scores_gemma":[0.9998716,0.000039706043,0.00002694898,0.000007616721,0.0000330772,0.000020969319],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026429933,0.00037478204,0.00029454683,0.0001372783,0.00010600074,0.00010142246,0.00024079296,0.00019351776,0.0006104413],"category_scores_gemma":[0.00023804914,0.0001357413,0.0002484311,0.00023533408,0.00012109315,0.00015837776,0.00013533935,0.00028874792,0.00017904163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030358872,0.000082245715,0.00022655902,0.00021103834,0.000022177466,0.000053496362,0.000029749071,0.00044163765,0.9960289,0.00005014378,0.000053370193,0.0024971063],"study_design_scores_gemma":[0.00002883531,0.0018548273,0.0020727487,0.000009394546,0.000022870554,0.00011296642,0.000019357745,0.0009828312,0.9933021,0.000017286897,0.001571252,0.000005460634],"about_ca_topic_score_codex":0.0029042002,"about_ca_topic_score_gemma":0.0031526033,"teacher_disagreement_score":0.0029042002,"about_ca_system_score_codex":0.00024497468,"about_ca_system_score_gemma":0.00021396058,"threshold_uncertainty_score":0.0057745576},"labels":[],"label_agreement":null},{"id":"W4226204268","doi":"10.1142/9789811228698_0027","title":"Extraction of Superoxide Dismutase, Catalase and Carbonic Anhydrase from Stroma-free Red Blood Cell Hemolysate for the Preparation of the Nanobiotechnological Complex of PolyHemoglobin-superoxide Dismutase-Catalase-carbonic Anhydrase","year":2021,"lang":"en","type":"book-chapter","venue":"Regenerative medicine, artificial cells and nanomedicine","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Catalase; Superoxide dismutase; Carbonic anhydrase; Enzyme; Biochemistry; Chemistry; Dismutase; Molecular biology; Biology","score_opus":0.017920526466354413,"score_gpt":0.24126984056271625,"score_spread":0.22334931409636183,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4226204268","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.16358882,0.041570272,0.6959531,0.0013834441,0.0016920127,0.0006382146,0.0039058134,0.001866527,0.089401856],"genre_scores_gemma":[0.24124628,0.040140446,0.32509607,0.0008412527,0.0002110455,0.0007156992,0.012768982,0.0009141936,0.37806606],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999529,0.000002949354,0.0000028461425,0.000011797562,0.000025177953,0.000004286798],"domain_scores_gemma":[0.999969,0.000010962328,0.0000037563632,0.000004123532,0.000008662195,0.000003384603],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011059062,0.0003603287,0.00028424707,0.00026875944,0.00012725084,0.00023415056,0.0003246453,0.00020033927,0.0028393636],"category_scores_gemma":[0.00008823079,0.00016301098,0.00020970547,0.0003378124,0.00012716593,0.00037445867,0.00015775966,0.0006490227,0.0028404857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000021249132,0.000021634081,0.00004263891,0.00014222163,0.0000034557631,0.000054590477,0.000020468247,0.0001308041,0.9799355,0.0011719692,0.000847575,0.017607795],"study_design_scores_gemma":[0.000005602798,0.000047787336,0.0005994592,0.000023466084,0.000008377501,0.0003235137,0.000013637871,0.00065894565,0.9186548,0.0010238329,0.0786323,0.000008324334],"about_ca_topic_score_codex":0.00026283532,"about_ca_topic_score_gemma":0.00086382806,"teacher_disagreement_score":0.0028393636,"about_ca_system_score_codex":0.00019578611,"about_ca_system_score_gemma":0.00025043258,"threshold_uncertainty_score":0.009498596},"labels":[],"label_agreement":null},{"id":"W4234150503","doi":"10.2523/99787-ms","title":"Reducing the Permeability of Sandstone Porous Media to Water and CO2: Application of Bovine Carbonic Anhydrase Enzyme","year":2006,"lang":"en","type":"article","venue":"Proceedings of SPE/DOE Symposium on Improved Oil Recovery","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Regina","funders":"","keywords":"Carbonic anhydrase; Chemistry; Permeability (electromagnetism); Porous medium; Carbon dioxide; Chemical engineering; Carbonate; Calcium carbonate; Precipitation; Porosity; Enzyme; Biochemistry; Membrane; Organic chemistry","score_opus":0.0038122346027459853,"score_gpt":0.1975330765175021,"score_spread":0.1937208419147561,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4234150503","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99027425,0.001207348,0.007749724,0.00007352028,0.000018649156,0.000039777427,0.000050109706,0.0000612904,0.00052546884],"genre_scores_gemma":[0.98947644,0.0010508278,0.008731098,0.000023582947,0.00000763519,0.000017961265,0.000066241766,0.000012193182,0.0006141288],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986684,0.000017489621,0.000012086456,0.000029650577,0.000048101436,0.000025791007],"domain_scores_gemma":[0.99985707,0.00003691249,0.000049090904,0.000012421242,0.000025563535,0.00001900219],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020451353,0.0002957182,0.0002666502,0.00017531945,0.00009638518,0.00024738355,0.00019834544,0.00033530506,0.00016541586],"category_scores_gemma":[0.00026071287,0.00011486337,0.00027016317,0.00012823775,0.0002139879,0.00024078334,0.00017115602,0.00028470924,0.000057448044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000015241953,0.000009678578,0.00004547713,0.000018758206,0.0000014291035,0.000015721813,0.00000439052,0.000041949872,0.9992017,0.000006119806,0.0000024964188,0.0006369576],"study_design_scores_gemma":[0.0000017047166,0.00009190172,0.00056275324,0.0000012105578,0.0000040893287,0.00003137286,0.0000044083176,0.00035169124,0.998733,0.0000026921123,0.00021327095,0.0000019508807],"about_ca_topic_score_codex":0.0009476651,"about_ca_topic_score_gemma":0.0015524974,"teacher_disagreement_score":0.0009476651,"about_ca_system_score_codex":0.00020064609,"about_ca_system_score_gemma":0.0001509262,"threshold_uncertainty_score":0.0018842816},"labels":[],"label_agreement":null},{"id":"W4238870638","doi":"10.1002/ange.201407165","title":"Crystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO<sub>2</sub>","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Chemistry; Carbonic anhydrase; Enzyme; Catalysis; Substrate (aquarium); Stereochemistry; Combinatorial chemistry; Biochemistry; Biology","score_opus":0.010698079505418963,"score_gpt":0.23681125811520842,"score_spread":0.22611317860978947,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4238870638","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9580108,0.0018879691,0.0031113103,0.0026142863,0.0003574562,0.000040558916,0.0013074905,0.0007372573,0.031932827],"genre_scores_gemma":[0.9906053,0.0008330558,0.002968432,0.00025888407,0.00004751135,0.0000325353,0.001342348,0.00008365392,0.0038283763],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999006,0.0000071169216,0.0000027662609,0.000014758998,0.0000407053,0.00003410712],"domain_scores_gemma":[0.9998764,0.000026151774,0.00002951893,0.000011209766,0.000020375375,0.000036315418],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014146234,0.00032449124,0.00042160845,0.00020744946,0.0007268733,0.00079164584,0.0008899617,0.00079067587,0.0060008275],"category_scores_gemma":[0.00022736505,0.00025569077,0.00016126079,0.00031503028,0.00086014345,0.00047322598,0.00030477627,0.002586238,0.00036233352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0023582578,0.0006628256,0.004701881,0.0009469241,0.00013853602,0.0061419993,0.0015032789,0.0169258,0.88955265,0.019712739,0.036495667,0.020859463],"study_design_scores_gemma":[0.0008843531,0.0019522319,0.056828048,0.00029768248,0.0002463522,0.0029097046,0.0029506085,0.12246,0.6985407,0.006969299,0.10556044,0.00040058166],"about_ca_topic_score_codex":0.0112745855,"about_ca_topic_score_gemma":0.0133100785,"teacher_disagreement_score":0.0112745855,"about_ca_system_score_codex":0.0012759671,"about_ca_system_score_gemma":0.0012219615,"threshold_uncertainty_score":0.022417903},"labels":[],"label_agreement":null},{"id":"W4247082056","doi":"10.1107/s0108767308091575","title":"Crystal structure of α-carbonic anhydrase from<i>Chlamydomonas reinhardtii</i>","year":2008,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations of Crystallography","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences Centre; University of British Columbia","funders":"","keywords":"Chlamydomonas reinhardtii; Carbonic anhydrase; Chlamydomonas; Chemistry; Crystallography; Biochemistry; Enzyme; Gene","score_opus":0.009000123339623063,"score_gpt":0.22188241367123968,"score_spread":0.21288229033161662,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4247082056","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96463335,0.013289379,0.0013275722,0.0017920901,0.00039177784,0.0001007858,0.0072908173,0.00052365655,0.010650597],"genre_scores_gemma":[0.94285,0.007300441,0.0063946196,0.00072876725,0.00004600384,0.00011245201,0.031259038,0.000199156,0.011109651],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997285,0.000015979076,0.000010171034,0.000062771884,0.00011875544,0.0000639193],"domain_scores_gemma":[0.99973077,0.000040280785,0.000036581092,0.000010385282,0.00008716962,0.000094827774],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003554122,0.00051973545,0.0006920914,0.00021148371,0.00090363144,0.00071461004,0.001411935,0.0007141757,0.003263881],"category_scores_gemma":[0.00052824063,0.00035192442,0.0002697195,0.00053403736,0.00027507474,0.00038452644,0.00030117374,0.0014642858,0.00055011356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0040059164,0.0012167108,0.05649389,0.0037347528,0.0013700214,0.004928952,0.0026926312,0.026418867,0.7264672,0.006903214,0.11762249,0.048145346],"study_design_scores_gemma":[0.0021210883,0.0017410096,0.47291,0.0010150766,0.0012650252,0.004068754,0.003957865,0.08130186,0.1647104,0.001932262,0.26448038,0.00049631123],"about_ca_topic_score_codex":0.069597654,"about_ca_topic_score_gemma":0.07444016,"teacher_disagreement_score":0.069597654,"about_ca_system_score_codex":0.002641884,"about_ca_system_score_gemma":0.0023629451,"threshold_uncertainty_score":0.13838512},"labels":[],"label_agreement":null},{"id":"W4252654332","doi":"10.2174/2211334710801020093","title":"Scrubber Designs for Enzyme-Mediated Capture of CO2","year":2008,"lang":"en","type":"article","venue":"Recent Patents on Chemical Engineering","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Scrubber; Chemistry; Carbonic anhydrase; Carbon dioxide; Carbonation; Bicarbonate; Carbon dioxide removal; Chemical engineering; Waste management; Environmental chemistry; Organic chemistry; Enzyme","score_opus":0.02930945972713858,"score_gpt":0.22745691828659273,"score_spread":0.19814745855945415,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4252654332","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.40629607,0.2788572,0.26398832,0.000816128,0.0010838503,0.00066197023,0.0012358367,0.0023239926,0.044736624],"genre_scores_gemma":[0.7060567,0.16332947,0.09032884,0.0005421229,0.00027215327,0.00047573925,0.0016144181,0.0002491038,0.037131563],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996462,0.000027042524,0.000024444591,0.00009098912,0.0001661495,0.000045240355],"domain_scores_gemma":[0.9998995,0.000024258285,0.000032667536,0.000009476716,0.00002489834,0.000009170828],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026413155,0.00079025066,0.00063629035,0.00069540506,0.00017569683,0.00055200176,0.00075410487,0.0007166639,0.0014276882],"category_scores_gemma":[0.0002809,0.00031095775,0.00061047333,0.00067499734,0.00021913763,0.00072485337,0.00031834687,0.00067547965,0.0014720837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000068128276,0.000045187662,0.00009217017,0.0011975383,0.000027522714,0.00017466155,0.00004097139,0.00046615562,0.9591242,0.0012957699,0.0005191539,0.0369484],"study_design_scores_gemma":[0.000014685341,0.00033211813,0.00070536643,0.000052775024,0.000046449368,0.0005486486,0.000021315635,0.0012691015,0.9480455,0.00019295097,0.048750013,0.000021027477],"about_ca_topic_score_codex":0.00033321907,"about_ca_topic_score_gemma":0.00070712867,"teacher_disagreement_score":0.0014276882,"about_ca_system_score_codex":0.00047827265,"about_ca_system_score_gemma":0.00022510684,"threshold_uncertainty_score":0.0047760606},"labels":[],"label_agreement":null},{"id":"W4256183389","doi":"10.3109/10731199.2011.582041","title":"Polyhemoglobin-superoxide Dismutase-catalase-carbonic Anhydrase: A Novel Biotechnology-based Blood Substitute that Transports Both Oxygen and Carbon Dioxide and Also Acts as an Antioxidant","year":2011,"lang":"en","type":"article","venue":"Artificial Cells Blood Substitutes and Biotechnology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Carbonic anhydrase; Superoxide dismutase; Catalase; Antioxidant; Chemistry; Carbon dioxide; Oxygen; Biochemistry; Reactive oxygen species; Hemoglobin; Dismutase; Enzyme; Organic chemistry","score_opus":0.016266054285304827,"score_gpt":0.2050250588404421,"score_spread":0.18875900455513725,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4256183389","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9216256,0.005911005,0.06853714,0.00043903387,0.000106227155,0.00013122118,0.00023521022,0.0002807612,0.0027337046],"genre_scores_gemma":[0.9540251,0.0020069226,0.038604733,0.000074850504,0.00002585442,0.000071241004,0.00041519196,0.000059138365,0.0047170497],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987614,0.000016811293,0.000010086597,0.000027200644,0.00005936415,0.000010310838],"domain_scores_gemma":[0.99990785,0.000010706689,0.000039242892,0.000007493988,0.000014805939,0.000019903135],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015792294,0.00034527804,0.00015583874,0.00016184151,0.00009160356,0.00022750515,0.00024716335,0.00026133878,0.0003448731],"category_scores_gemma":[0.00012558431,0.00011198362,0.00013726797,0.00017701702,0.00018807249,0.00021320343,0.00012471317,0.00034820038,0.00019847428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000017827002,0.000023817249,0.000119076256,0.000027858146,0.0000024022404,0.0000142545305,0.0000038852304,0.00007310716,0.99785197,0.00012360522,0.000036359037,0.0017059149],"study_design_scores_gemma":[0.000004691982,0.0000708478,0.00036865182,0.0000013266452,0.000005839294,0.00012427538,0.000001518871,0.00046692774,0.99644804,0.000013893547,0.0024923268,0.0000017040051],"about_ca_topic_score_codex":0.0003519229,"about_ca_topic_score_gemma":0.0006788889,"teacher_disagreement_score":0.0003519229,"about_ca_system_score_codex":0.00033068322,"about_ca_system_score_gemma":0.00025819935,"threshold_uncertainty_score":0.0023993254},"labels":[],"label_agreement":null},{"id":"W4280621380","doi":"10.1016/j.seppur.2022.121299","title":"Recent advancements in carbonic anhydrase immobilization and its implementation in CO2 capture technologies: A review","year":2022,"lang":"en","type":"review","venue":"Separation and Purification Technology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Carbonic anhydrase; Chemistry; Biochemical engineering; Nanotechnology; Engineering; Biochemistry; Materials science; Enzyme","score_opus":0.026504748420957954,"score_gpt":0.3610233953155271,"score_spread":0.3345186468945691,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4280621380","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0002360748,0.9982844,0.00042485262,0.00012915615,0.00016656716,0.000006122929,0.00004098603,0.00001259937,0.0006992828],"genre_scores_gemma":[0.00066068914,0.998262,0.00041556696,0.000113465125,0.000106641666,0.000006392303,0.00005132411,0.0000024037226,0.00038144583],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99977845,0.000023205837,0.00002946935,0.000054082226,0.00008990203,0.000024947898],"domain_scores_gemma":[0.9995359,0.00025537112,0.000065869935,0.000014048386,0.00010244224,0.000026373804],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00076373725,0.0010304698,0.0014346848,0.0021677446,0.00021061019,0.001090657,0.0009072786,0.00083473424,0.002816095],"category_scores_gemma":[0.0010455896,0.00037436534,0.0006039039,0.0027927284,0.0003271224,0.0012584506,0.0007140035,0.0011340885,0.0014362042],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010748997,0.00009787857,0.00021760463,0.036255337,0.00014283482,0.00014466081,0.000046816695,0.0006766922,0.0073185004,0.00239717,0.01542602,0.93716896],"study_design_scores_gemma":[0.0000211307,0.0001954273,0.00097493053,0.0035729306,0.00038802015,0.00067320716,0.00006173279,0.00025821044,0.00459027,0.0014636054,0.9877488,0.00005170748],"about_ca_topic_score_codex":0.0011700529,"about_ca_topic_score_gemma":0.001977109,"teacher_disagreement_score":0.002816095,"about_ca_system_score_codex":0.00046067816,"about_ca_system_score_gemma":0.0012182855,"threshold_uncertainty_score":0.0094207525},"labels":[],"label_agreement":null},{"id":"W4283576277","doi":"10.1080/14756366.2022.2092729","title":"Structure-activity relationship studies for inhibitors for vancomycin-resistant <i>Enterococcus</i> and human carbonic anhydrases","year":2022,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Carbonic anhydrase; Acetazolamide; Enzyme; Enterococcus faecium; Enterococcus faecalis; Druggability; Microbiology; Chemistry; Homology modeling; Enterococcus; Carbonic anhydrase II; Vancomycin-Resistant Enterococci; Mechanism of action; Active site; Vancomycin; Biochemistry; Bacteria; Antibiotics; Biology; Staphylococcus aureus; Escherichia coli; In vitro; Gene; Genetics","score_opus":0.023740359660572447,"score_gpt":0.2989710084151617,"score_spread":0.27523064875458925,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4283576277","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97551334,0.01683855,0.0024800203,0.0002720847,0.00003704548,0.000053083975,0.0006144369,0.000061172635,0.0041301455],"genre_scores_gemma":[0.99068743,0.0047779186,0.0023025472,0.00007199139,0.000008714576,0.00002052042,0.00074147974,0.000008680345,0.0013807531],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984884,0.0000339139,0.000011541748,0.000023649245,0.00005002956,0.000031891137],"domain_scores_gemma":[0.9998604,0.00004629066,0.00003891876,0.0000053785006,0.000030068755,0.000018843806],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026798414,0.00031241978,0.00048618845,0.00017688153,0.000125273,0.0002876483,0.00038739876,0.0002537719,0.0014060108],"category_scores_gemma":[0.00039541043,0.00017270804,0.00039087728,0.00025599764,0.0001373295,0.0002519308,0.00013385492,0.00056616054,0.00019764337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0025688857,0.0010335587,0.004892375,0.0010504378,0.0003212985,0.00061050354,0.00020094853,0.081610374,0.87770605,0.0024938965,0.0017059967,0.025805626],"study_design_scores_gemma":[0.00066494656,0.015063751,0.015629219,0.00009532998,0.0004762392,0.0013536408,0.00021050997,0.13800202,0.8072895,0.00058005773,0.020515425,0.000119341836],"about_ca_topic_score_codex":0.0024607002,"about_ca_topic_score_gemma":0.0030627046,"teacher_disagreement_score":0.0024607002,"about_ca_system_score_codex":0.00052070734,"about_ca_system_score_gemma":0.000318005,"threshold_uncertainty_score":0.0048927665},"labels":[],"label_agreement":null},{"id":"W4283822894","doi":"10.1016/j.molstruc.2022.133672","title":"Sulfonamide diuretic azosemide as an efficient carbonic anhydrase inhibitor","year":2022,"lang":"en","type":"article","venue":"Journal of Molecular Structure","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ministerul Cercetării şi Inovării; Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Loop diuretic; Furosemide; Pharmacology; Carbonic anhydrase; Potency; Diuretic; Bioisostere; Sulfonamide; In vitro; Stereochemistry; Biochemistry; Enzyme; Chemical synthesis; Organic chemistry; Medicine","score_opus":0.0027996325521294327,"score_gpt":0.21791834576837185,"score_spread":0.21511871321624243,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4283822894","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9683092,0.015486807,0.007922657,0.0004650661,0.00027839214,0.00012377067,0.00028571574,0.00016342015,0.006964987],"genre_scores_gemma":[0.99081844,0.002584699,0.003559716,0.000066402,0.000037239974,0.000020580268,0.0002789253,0.00001031476,0.0026236812],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986076,0.000029636374,0.000009097962,0.00001694641,0.000055180062,0.000028378945],"domain_scores_gemma":[0.9999528,0.000008544906,0.0000060929474,0.000003813771,0.000010297849,0.00001854736],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022428032,0.00023290812,0.0002948056,0.0001655039,0.00014754948,0.00026211658,0.00035848827,0.00018764366,0.00056117756],"category_scores_gemma":[0.00014212361,0.00010499916,0.00013935183,0.00013225783,0.00015455631,0.00015413114,0.00014769375,0.00042152105,0.00014175264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009964089,0.00013055564,0.0004526352,0.000071253766,0.00002607166,0.00018137439,0.000020791573,0.00045218068,0.98141164,0.00079694536,0.00052281446,0.014937305],"study_design_scores_gemma":[0.00044644106,0.0023239604,0.003800812,0.000010463402,0.00008004835,0.0008239571,0.0000143679135,0.0051024035,0.9652094,0.000117923504,0.022056824,0.00001334713],"about_ca_topic_score_codex":0.0016620995,"about_ca_topic_score_gemma":0.0038763043,"teacher_disagreement_score":0.0016620995,"about_ca_system_score_codex":0.0003569618,"about_ca_system_score_gemma":0.00041406875,"threshold_uncertainty_score":0.0033047795},"labels":[],"label_agreement":null},{"id":"W4283837951","doi":"10.3390/cancers14143297","title":"Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; McMaster University","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Cancer immunotherapy; Medicine; Cancer; Hypoxia (environmental); Immunotherapy; Cancer research; Bench to bedside; Effector; Targeted therapy; Pharmacology; Immunology; Chemistry; Internal medicine","score_opus":0.014940821889570315,"score_gpt":0.2575463597207561,"score_spread":0.2426055378311858,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4283837951","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0043143956,0.84690374,0.0055088312,0.078777656,0.054341637,0.0000373273,0.00010949007,0.000098401,0.009908462],"genre_scores_gemma":[0.02493343,0.86927736,0.0021170618,0.031803656,0.04349373,0.000047619153,0.00012522521,0.000046855497,0.028155128],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981016,0.00003951232,0.000013946528,0.000031040854,0.00008205176,0.00002339503],"domain_scores_gemma":[0.9998204,0.00005849479,0.000018311517,0.0000044807803,0.00007085988,0.00002733982],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044250226,0.00039273547,0.00048429272,0.00024808507,0.000242319,0.0008041307,0.00058451865,0.0015013118,0.001512682],"category_scores_gemma":[0.0006021056,0.00009018024,0.0002623501,0.00020854974,0.00053920253,0.00079139497,0.00030990533,0.0021844783,0.0006886379],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003743993,0.00007403586,0.000325591,0.004718087,0.000082856706,0.0019159949,0.00020916706,0.0011720556,0.06184961,0.03360158,0.58733934,0.30833727],"study_design_scores_gemma":[0.000016504411,0.00012648068,0.000250879,0.00028018877,0.000027855993,0.0012063549,0.00004683576,0.00028928753,0.0076445118,0.0029344705,0.9871638,0.000012793273],"about_ca_topic_score_codex":0.00056254555,"about_ca_topic_score_gemma":0.0026956096,"teacher_disagreement_score":0.001512682,"about_ca_system_score_codex":0.00085759046,"about_ca_system_score_gemma":0.0006111446,"threshold_uncertainty_score":0.0062223077},"labels":[],"label_agreement":null},{"id":"W4292773246","doi":"10.2139/ssrn.4193121","title":"A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Discovery Centre; BC Children's Hospital; BC Cancer Agency","funders":"","keywords":"Glutamine; Metabolism; Chemistry; Carbonic anhydrase; Biochemistry; Cell biology; Cancer research; Enzyme; Biology; Amino acid","score_opus":0.004014888610159612,"score_gpt":0.19859445798370928,"score_spread":0.19457956937354967,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4292773246","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99213105,0.0018976575,0.0021749167,0.00033190683,0.000057127905,0.000012523273,0.00038793738,0.000111289635,0.0028956828],"genre_scores_gemma":[0.9961972,0.0003614942,0.0005724993,0.00005414855,0.0000061548317,0.0000066271,0.00022011819,0.000014315627,0.002567532],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991393,0.000009378027,0.0000059351814,0.000022833303,0.000025656456,0.00002232186],"domain_scores_gemma":[0.9999429,0.0000045282377,0.000018745806,0.000004209301,0.000008526898,0.000021028773],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000095765485,0.00014658886,0.00017052707,0.00011956403,0.00016331451,0.0002917089,0.00016286758,0.00019538385,0.0018371282],"category_scores_gemma":[0.000079720514,0.000079755715,0.00014140784,0.000102138045,0.0001704609,0.00012529282,0.00015231526,0.00028614607,0.0002910627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014045292,0.0000072054777,0.00043615638,0.000021465206,0.000005383905,0.000049607774,0.000011440263,0.000049850398,0.9977449,0.0002872114,0.000101955935,0.0011444223],"study_design_scores_gemma":[0.00002992698,0.00019110253,0.019239787,0.00001006509,0.000032896263,0.00032264288,0.000093732044,0.0020424684,0.97100574,0.00020438121,0.006821484,0.000005811056],"about_ca_topic_score_codex":0.0018523962,"about_ca_topic_score_gemma":0.003368232,"teacher_disagreement_score":0.0018523962,"about_ca_system_score_codex":0.000518912,"about_ca_system_score_gemma":0.0003042972,"threshold_uncertainty_score":0.006145835},"labels":[],"label_agreement":null},{"id":"W4310017070","doi":"10.1016/j.ejmech.2022.114958","title":"Design and synthesis of new adamantyl derivatives as promising antiproliferative agents","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Higher Education Commision, Pakistan; University of Sharjah; Mitacs; Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Cell culture; Carbonic anhydrase; Cytotoxicity; Cytotoxic T cell; Enzyme; Cancer cell; Docking (animal); Stereochemistry; Biochemistry; Cancer; Pharmacology; In vitro; Biology","score_opus":0.020304504438887244,"score_gpt":0.24670797641442338,"score_spread":0.22640347197553615,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4310017070","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9237962,0.018273767,0.03804389,0.0010035665,0.00041451523,0.0005072052,0.0009991432,0.00038493227,0.016576665],"genre_scores_gemma":[0.9484715,0.015365074,0.02234534,0.00024993348,0.000091878595,0.00021572998,0.000826592,0.00006116781,0.012372722],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991107,0.000019322822,0.000010555962,0.000013691575,0.000017884195,0.00002739638],"domain_scores_gemma":[0.9999411,0.0000075894645,0.000014423536,0.0000066142466,0.000010472611,0.000019789777],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030895512,0.00051258097,0.00044804538,0.00024547547,0.00018338599,0.00033643216,0.00054040726,0.0002828074,0.0026271695],"category_scores_gemma":[0.00015970561,0.00024009055,0.00026670485,0.00026072905,0.00022605428,0.00041982936,0.00029028094,0.0006486214,0.00079120987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00077196484,0.00039249827,0.0003440798,0.00076233543,0.00006565644,0.0016099435,0.00036761956,0.004403115,0.93000627,0.009589752,0.0016288239,0.050058093],"study_design_scores_gemma":[0.00049827807,0.005664746,0.0011058352,0.00008584094,0.00012621569,0.0013856927,0.00010033191,0.0044245133,0.9171081,0.0015911927,0.067843445,0.00006588367],"about_ca_topic_score_codex":0.00016124047,"about_ca_topic_score_gemma":0.00044492737,"teacher_disagreement_score":0.0026271695,"about_ca_system_score_codex":0.00021066339,"about_ca_system_score_gemma":0.0002634952,"threshold_uncertainty_score":0.0087887645},"labels":[],"label_agreement":null},{"id":"W4362552195","doi":"10.1007/s00044-023-03043-9","title":"Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX","year":2023,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Carbonic anhydrase; Chemistry; Acetazolamide; IC50; Carbonic anhydrase inhibitor; Isozyme; Gene isoform; Enzyme; Carbonic Anhydrase I; Biochemistry; Stereochemistry; In vitro; Gene; Internal medicine","score_opus":0.09563278937218482,"score_gpt":0.3842684170287194,"score_spread":0.28863562765653455,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4362552195","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97274584,0.0087749595,0.007322366,0.00025431803,0.00016350595,0.00044175418,0.0010001617,0.00017104909,0.009126051],"genre_scores_gemma":[0.98647887,0.0049366336,0.0035857535,0.000081267266,0.000042567335,0.00008460191,0.0008585888,0.00001836874,0.0039133294],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998609,0.0000304121,0.000016062711,0.000017491453,0.00003472578,0.000040468356],"domain_scores_gemma":[0.999915,0.000012077809,0.000016596301,0.000008860591,0.00001877946,0.00002860883],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034889535,0.00047269042,0.00042432646,0.00032742444,0.00020940816,0.00018408641,0.00040661418,0.00034161762,0.0018061169],"category_scores_gemma":[0.00020741644,0.00018832981,0.0003312695,0.00024779522,0.00018818317,0.00019283898,0.00017261552,0.0003536799,0.00039483054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016974161,0.00051197753,0.00031825685,0.00028563046,0.000054766355,0.0006265881,0.000105666135,0.0019361158,0.9725107,0.00093028386,0.00068508857,0.020337574],"study_design_scores_gemma":[0.00062707294,0.012552587,0.0023891127,0.000030112216,0.00011153391,0.00073935464,0.000045872668,0.0015876729,0.9672463,0.00015060764,0.014491545,0.000028301383],"about_ca_topic_score_codex":0.00090875075,"about_ca_topic_score_gemma":0.0013896457,"teacher_disagreement_score":0.0018061169,"about_ca_system_score_codex":0.00021182961,"about_ca_system_score_gemma":0.0003463885,"threshold_uncertainty_score":0.0060420632},"labels":[],"label_agreement":null},{"id":"W4377990755","doi":"10.1016/j.bioorg.2023.106621","title":"Substituted furan sulfonamides as carbonic anhydrase inhibitors: Synthesis, biological and in silico studies","year":2023,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Ministerul Cercetării, Inovării şi Digitalizării; Corporation for National and Community Service","keywords":"Chemistry; Acetazolamide; Carbonic anhydrase; Active site; In silico; Gene isoform; ADME; Carbonic Anhydrase I; Biochemistry; Bioavailability; Sulfonamide; Stereochemistry; Enzyme; Pharmacology; In vitro; Gene","score_opus":0.024711343115464534,"score_gpt":0.26876345377029076,"score_spread":0.24405211065482624,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4377990755","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96629035,0.0139427995,0.01192873,0.0003229416,0.000071527946,0.00017872687,0.00060968474,0.00012379164,0.006531481],"genre_scores_gemma":[0.9809662,0.008789416,0.0071847253,0.00004732273,0.000017192131,0.000038402726,0.00043068302,0.000019252659,0.0025068843],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998087,0.00006590381,0.0000094257875,0.000029670322,0.000052180716,0.000034156816],"domain_scores_gemma":[0.99986565,0.000052084048,0.000024668478,0.000010398854,0.000028412229,0.000018819319],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054323557,0.00059013785,0.00056365813,0.00019705965,0.00020043175,0.00044176934,0.00049364875,0.00034173735,0.0013791373],"category_scores_gemma":[0.0004999335,0.00018720691,0.0003850038,0.00026555138,0.00022471785,0.00030673514,0.0001811818,0.00056271313,0.00033015964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018502652,0.0011899351,0.0018675275,0.0015694269,0.00031365105,0.0010609141,0.00026100175,0.069824815,0.8446122,0.007937423,0.001748476,0.06776442],"study_design_scores_gemma":[0.0003737369,0.006701536,0.0016015618,0.00012741395,0.0004119607,0.000801315,0.00014759177,0.06137333,0.8983984,0.00088259846,0.029078934,0.000101583544],"about_ca_topic_score_codex":0.0020450982,"about_ca_topic_score_gemma":0.0030824812,"teacher_disagreement_score":0.0020450982,"about_ca_system_score_codex":0.00075112487,"about_ca_system_score_gemma":0.0004964979,"threshold_uncertainty_score":0.0054498315},"labels":[],"label_agreement":null},{"id":"W4380894068","doi":"10.1016/j.str.2023.05.015","title":"Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii","year":2023,"lang":"en","type":"article","venue":"Structure","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Thioesterase; Acinetobacter baumannii; Biochemistry; Enzyme; Active site; Chemistry; Carbonic anhydrase; Hydrolase; Biology; Bacteria; Biosynthesis; Pseudomonas aeruginosa","score_opus":0.005695839482156797,"score_gpt":0.216248223981857,"score_spread":0.2105523844997002,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4380894068","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9780492,0.005299017,0.010095939,0.0014879166,0.000107732834,0.000027142998,0.00027227218,0.00017409756,0.004486645],"genre_scores_gemma":[0.9940612,0.0015065302,0.00319442,0.0000802873,0.000011827354,0.000008853725,0.00021843213,0.000008681884,0.00090978725],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999938,0.000012365701,0.000004466353,0.000009239233,0.000020007377,0.000015917461],"domain_scores_gemma":[0.9999571,0.000009270001,0.000009935675,0.000004365321,0.0000064671913,0.000012946112],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021811953,0.00053986104,0.00030354297,0.00014165738,0.0003554005,0.0005606202,0.00051668484,0.0005641295,0.00088406156],"category_scores_gemma":[0.0001742249,0.00017556269,0.00018574235,0.00017191298,0.00049615133,0.00052064407,0.00027211467,0.00104417,0.00023709146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00091998774,0.00019644297,0.0018132149,0.00031984027,0.000026182879,0.0014593273,0.00023078946,0.01243494,0.9448541,0.023838438,0.00058340613,0.013323394],"study_design_scores_gemma":[0.00012399777,0.0008326997,0.004088046,0.000036605816,0.00005725869,0.002251817,0.00060327066,0.04335332,0.92437094,0.008014355,0.016209649,0.000058084668],"about_ca_topic_score_codex":0.0017419786,"about_ca_topic_score_gemma":0.0013231069,"teacher_disagreement_score":0.0017419786,"about_ca_system_score_codex":0.0008420268,"about_ca_system_score_gemma":0.0006297697,"threshold_uncertainty_score":0.0061092973},"labels":[],"label_agreement":null},{"id":"W4385354381","doi":"10.1016/b978-0-443-15461-4.00017-5","title":"Final words","year":2023,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Computer science; Linguistics; Philosophy","score_opus":0.022552591356533848,"score_gpt":0.24339554552848233,"score_spread":0.2208429541719485,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385354381","genre_codex":"other","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":"other","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00028654395,0.0008304723,0.00046106798,0.0008342917,0.0019529541,0.000048573966,0.00063320773,0.0002603827,0.9946925],"genre_scores_gemma":[0.000398409,0.00020966325,0.00010958316,0.00011049004,0.00011337332,0.000008346563,0.00019774788,0.000050355808,0.99880207],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9996313,0.000026382257,0.000017384673,0.000086636355,0.00019309837,0.000045196728],"domain_scores_gemma":[0.9996131,0.000044334458,0.000015824788,0.000056717403,0.00016118532,0.000108769695],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003435398,0.0010563688,0.0006701413,0.001805805,0.001568825,0.003994651,0.00093006,0.0017792543,0.7936893],"category_scores_gemma":[0.0009034377,0.00035240297,0.0004897007,0.0012459666,0.0005202732,0.0021379783,0.001794839,0.0014944104,0.75502366],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000045492277,0.000027972692,0.00010529445,0.0001305648,0.0000029466614,0.0001037266,0.000055019893,0.000105262734,0.00069878506,0.014573302,0.80491143,0.17924033],"study_design_scores_gemma":[0.0000031606016,0.00000619115,0.00009878152,0.000036297333,9.045875e-7,0.000043318643,0.000025689984,0.000022487973,0.00013110772,0.0015250003,0.99810505,0.0000020138405],"about_ca_topic_score_codex":0.0023641505,"about_ca_topic_score_gemma":0.005317025,"teacher_disagreement_score":0.7936893,"about_ca_system_score_codex":0.0011704006,"about_ca_system_score_gemma":0.00096254953,"threshold_uncertainty_score":0.29427713},"labels":[],"label_agreement":null},{"id":"W4385354997","doi":"10.1016/b978-0-443-15461-4.00002-3","title":"pH Regulation and metabolism: Basic concepts","year":2023,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Metabolism; Computer science; Computational biology; Chemistry; Biology; Biochemistry","score_opus":0.013851593278710125,"score_gpt":0.24173467870029833,"score_spread":0.2278830854215882,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385354997","genre_codex":"other","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0029048116,0.37620494,0.080754235,0.0031631126,0.002911475,0.00006268646,0.0002593397,0.0004908555,0.5332485],"genre_scores_gemma":[0.047724005,0.35443825,0.03215038,0.002648437,0.0051739886,0.00029559384,0.0003900752,0.00019831305,0.5569809],"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","domain_scores_codex":[0.999928,0.000007936114,0.0000043342397,0.000019435613,0.00003340878,0.000007007444],"domain_scores_gemma":[0.99997246,0.000011110146,0.0000025987442,0.0000035628236,0.0000061320898,0.000004109484],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963387,0.0010509829,0.00067770464,0.0007987837,0.00030449076,0.001475289,0.0009340718,0.0011594291,0.014102],"category_scores_gemma":[0.0001182966,0.00035775165,0.00032963787,0.0011037819,0.0013525531,0.0022602591,0.00088225026,0.001574969,0.0100001125],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000069717054,0.00007452549,0.00008454763,0.00120147,0.000017805121,0.000285268,0.00029117113,0.0020074146,0.016836433,0.48699236,0.053618435,0.43852085],"study_design_scores_gemma":[0.000010664722,0.000042925334,0.0002875942,0.00024552195,0.0000100433945,0.0005459958,0.00006575043,0.001172065,0.0025469933,0.2400062,0.75504994,0.000016450294],"about_ca_topic_score_codex":0.0004437998,"about_ca_topic_score_gemma":0.00043117214,"teacher_disagreement_score":0.014102,"about_ca_system_score_codex":0.000693652,"about_ca_system_score_gemma":0.00036328708,"threshold_uncertainty_score":0.047175944},"labels":[],"label_agreement":null},{"id":"W4385355056","doi":"10.1016/b978-0-443-15461-4.00013-8","title":"Carbonic anhydrases (CAs)","year":2023,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Computational biology; Chemistry; Biology","score_opus":0.01468754059982014,"score_gpt":0.23322461381764667,"score_spread":0.21853707321782653,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385355056","genre_codex":"other","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0026771175,0.26388383,0.0120917745,0.0019367404,0.0031936658,0.00006439457,0.0010489202,0.0011094433,0.7139941],"genre_scores_gemma":[0.0054113297,0.06069525,0.003815499,0.0004388623,0.00040062482,0.000043088665,0.0005955327,0.000109539826,0.92849016],"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","domain_scores_codex":[0.99989796,0.0000038540647,0.0000051704187,0.000027201651,0.00005687051,0.000008982154],"domain_scores_gemma":[0.9999579,0.000011053222,0.0000046206187,0.0000056959325,0.000011615348,0.000009114782],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012790228,0.0011695303,0.0005162221,0.00086819235,0.0002980883,0.0011836241,0.00058100634,0.0010141177,0.07008047],"category_scores_gemma":[0.00016118913,0.00029812526,0.00026618765,0.0010402595,0.0003339594,0.0009709816,0.000646037,0.0013120121,0.07019749],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006256088,0.000034166005,0.00009788814,0.0005970868,0.000011011954,0.00019496719,0.00004778086,0.00030388616,0.03271382,0.01711141,0.13966967,0.8091558],"study_design_scores_gemma":[0.0000050677277,0.00001623305,0.00014565217,0.00007870086,0.0000053059916,0.00033577144,0.0000085728625,0.00009271141,0.0034757482,0.0016560184,0.99417615,0.000004096877],"about_ca_topic_score_codex":0.0022730562,"about_ca_topic_score_gemma":0.004404418,"teacher_disagreement_score":0.07008047,"about_ca_system_score_codex":0.00060257746,"about_ca_system_score_gemma":0.00056736515,"threshold_uncertainty_score":0.23444247},"labels":[],"label_agreement":null},{"id":"W4385622350","doi":"10.3389/fbioe.2023.1231384","title":"Preliminary feasibility study using a solution of synthetic enzymes to replace the natural enzymes in polyhemoglobin-catalase-superoxide dismutase-carbonic anhydrase: effect on warm ischemic hepatocyte cell culture","year":2023,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"McGill University","keywords":"Enzyme; Catalase; Superoxide dismutase; Carbonic anhydrase; Biochemistry; Viability assay; Chemistry; Antioxidant; Cell","score_opus":0.0066457853291036866,"score_gpt":0.22718280149377806,"score_spread":0.2205370161646744,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385622350","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.970658,0.0056180772,0.020891,0.00034538071,0.00014641533,0.00019887225,0.00017840398,0.00006969697,0.0018941419],"genre_scores_gemma":[0.97095674,0.003130637,0.021772286,0.00010171908,0.000037224312,0.00011304023,0.00034704604,0.000018949107,0.0035223146],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999851,0.000038048045,0.000016914095,0.000034062035,0.000042063846,0.000017865272],"domain_scores_gemma":[0.999813,0.00005567822,0.00003512261,0.00001852034,0.000049745504,0.00002789991],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043298857,0.0004275919,0.0002642996,0.00012481917,0.000161674,0.00026142577,0.00027244823,0.0006078268,0.00086030783],"category_scores_gemma":[0.00022965184,0.00008927303,0.00036954664,0.00010798065,0.0001771021,0.0003134431,0.0001778823,0.00041535418,0.00023759382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008431038,0.0000831749,0.00009118916,0.00008227098,0.0000038304884,0.00005259581,0.0000126640025,0.00008469373,0.9979296,0.000034538203,0.00002218548,0.001518992],"study_design_scores_gemma":[0.000011044322,0.0013639269,0.00048992614,0.0000049820405,0.000019171637,0.00011146181,0.000016258828,0.00030584272,0.99667263,0.000012574458,0.0009886116,0.0000035871703],"about_ca_topic_score_codex":0.00045469738,"about_ca_topic_score_gemma":0.000513118,"teacher_disagreement_score":0.00086030783,"about_ca_system_score_codex":0.00013670757,"about_ca_system_score_gemma":0.00018011729,"threshold_uncertainty_score":0.0028780103},"labels":[],"label_agreement":null},{"id":"W4386151888","doi":"10.1080/19420862.2023.2248672","title":"Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display","year":2023,"lang":"en","type":"article","venue":"mAbs","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Epitope; Chemistry; Epitope mapping; Nuclear magnetic resonance spectroscopy; Carbonic anhydrase; Linear epitope; Biochemistry; Surface plasmon resonance; Biophysics; Antibody; Molecular biology; Biology; Enzyme; Stereochemistry","score_opus":0.007115238545590655,"score_gpt":0.24980120367939307,"score_spread":0.24268596513380242,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386151888","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9943929,0.00030433902,0.0045819213,0.000027726783,0.0000068376758,0.000015199312,0.000049035636,0.000029777404,0.0005922283],"genre_scores_gemma":[0.99360704,0.00016284827,0.005429723,0.000044402954,0.000003344391,0.000014089035,0.00013615776,0.000011982129,0.00059042126],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997787,0.000060122075,0.000009484685,0.000045940604,0.000058558824,0.000047196565],"domain_scores_gemma":[0.9999057,0.000032401247,0.000017162936,0.0000084015555,0.000017725928,0.000018615026],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018503863,0.00039563418,0.00025121123,0.0001094424,0.00009922934,0.00020838497,0.00030309736,0.00026884428,0.0004263747],"category_scores_gemma":[0.0001802659,0.00015369219,0.00018682922,0.000106496685,0.00011007907,0.00013661975,0.00019243914,0.00035998638,0.00019213735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003002088,0.000015619085,0.00007187959,0.000009640101,0.0000037084362,0.000020528454,0.000007893981,0.00009741693,0.99932766,0.000027584987,0.000010853428,0.0003772268],"study_design_scores_gemma":[0.0000129166065,0.00016443248,0.0016979328,0.0000020643502,0.000010796923,0.00011330028,0.00001525603,0.0043892725,0.99286485,0.000024294466,0.00069940614,0.000005452284],"about_ca_topic_score_codex":0.0005671302,"about_ca_topic_score_gemma":0.00085183873,"teacher_disagreement_score":0.0005671302,"about_ca_system_score_codex":0.00023869392,"about_ca_system_score_gemma":0.00008833989,"threshold_uncertainty_score":0.001731813},"labels":[],"label_agreement":null},{"id":"W4387448736","doi":"10.1073/pnas.2304668120","title":"Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a <i>Burkholderia</i> bacterium","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University","funders":"National Center for Complementary and Integrative Health; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Nonribosomal peptide; Identification (biology); Microbiology; Burkholderia; Bacteria; Biology; Botany; Genetics; Gene; Biosynthesis","score_opus":0.022305972062395756,"score_gpt":0.2703783803820585,"score_spread":0.24807240831966276,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4387448736","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9945141,0.00021286438,0.004264531,0.000074716016,0.00000760498,0.00003463399,0.0004279544,0.00004188875,0.0004216657],"genre_scores_gemma":[0.9869643,0.00027411774,0.009464064,0.000045056982,0.0000045885463,0.000023981534,0.0015873874,0.000022611155,0.0016138558],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999192,0.000014226325,0.000008523685,0.000021705426,0.000021734177,0.000014585862],"domain_scores_gemma":[0.999907,0.000021072585,0.000029555496,0.000009628861,0.000011485759,0.000021322932],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010336496,0.00026874995,0.00017799903,0.00016221231,0.00007027913,0.00016803588,0.00013207686,0.00024849578,0.00032985353],"category_scores_gemma":[0.00014422685,0.00007632334,0.00020364122,0.00016739972,0.000109165674,0.00017112894,0.00022482607,0.00026124535,0.00024659184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000025763384,0.000007786849,0.00023088654,0.000010116989,0.0000016053862,0.000056378816,0.000006531402,0.00003642962,0.9988065,0.000017812397,0.000004417927,0.000795956],"study_design_scores_gemma":[0.000005569487,0.00023017294,0.0046631144,0.0000029795567,0.000009763071,0.00028610922,0.000031956668,0.000539809,0.99351126,0.00003154111,0.00068405515,0.000003691366],"about_ca_topic_score_codex":0.00030010176,"about_ca_topic_score_gemma":0.00036251626,"teacher_disagreement_score":0.00032985353,"about_ca_system_score_codex":0.00014221405,"about_ca_system_score_gemma":0.00012671952,"threshold_uncertainty_score":0.0011034608},"labels":[],"label_agreement":null},{"id":"W4388928854","doi":"10.1080/14756366.2023.2284119","title":"Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates","year":2023,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Neisseria gonorrhoeae; Enterococcus faecium; Bacteria; Microbiology; Enzyme; Growth inhibition; Chemistry; In vitro; Antibiotics; Biology; Biochemistry","score_opus":0.00750396726650443,"score_gpt":0.22977983738093816,"score_spread":0.22227587011443373,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4388928854","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97957957,0.011829351,0.0028786277,0.00017968763,0.00006339047,0.00012417954,0.00030545588,0.000110127614,0.004929568],"genre_scores_gemma":[0.98999363,0.005497604,0.0025543713,0.00005347545,0.000017412473,0.000043230397,0.00021491518,0.000006756601,0.0016186495],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990714,0.000021118476,0.000008040759,0.000014648612,0.000029917925,0.000019242387],"domain_scores_gemma":[0.9999163,0.000031171305,0.000019205218,0.0000067539827,0.00001162026,0.000014940188],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011395395,0.0003893117,0.00023780526,0.0001818469,0.00010648816,0.00012553978,0.00019014988,0.00020538314,0.0010068355],"category_scores_gemma":[0.00016096674,0.00010253268,0.0002028374,0.00014720968,0.00014845097,0.000092854345,0.00013967589,0.00035792717,0.00017984923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014516445,0.00006219621,0.00021098292,0.00020001369,0.000016949421,0.00007255618,0.000015155578,0.0003274565,0.9941857,0.000082168626,0.00006341112,0.0046182033],"study_design_scores_gemma":[0.00004421614,0.0018380887,0.0032711274,0.000013588956,0.000027114032,0.00025358825,0.000014275356,0.00063760346,0.99079484,0.00004044655,0.0030574806,0.000007695757],"about_ca_topic_score_codex":0.0009593346,"about_ca_topic_score_gemma":0.0032214108,"teacher_disagreement_score":0.0010068355,"about_ca_system_score_codex":0.00016679634,"about_ca_system_score_gemma":0.00023145216,"threshold_uncertainty_score":0.0033681989},"labels":[],"label_agreement":null},{"id":"W4389203616","doi":"10.3389/fmolb.2023.1327310","title":"Co-vulnerabilities of inhibiting carbonic anhydrase IX in ferroptosis-mediated tumor cell death","year":2023,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Cancer cell; Programmed cell death; Cancer; Cytotoxicity; Chemistry; Medicine; Pharmacology; Biology; Biochemistry; Apoptosis; Internal medicine","score_opus":0.008282438435988424,"score_gpt":0.23807720705048957,"score_spread":0.22979476861450115,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389203616","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00229127,0.9927481,0.0010055695,0.0003797123,0.00065347506,0.000015756823,0.000033811997,0.00002860188,0.002843778],"genre_scores_gemma":[0.010800779,0.9834489,0.0009478886,0.0004310152,0.0006295083,0.000034907924,0.00008757574,0.000010774934,0.0036085711],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998524,0.000020703761,0.000018662025,0.000028047523,0.00005968068,0.00002041877],"domain_scores_gemma":[0.99989355,0.00003457157,0.000024504187,0.00000428869,0.000032277272,0.000010683139],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029702872,0.0005784406,0.00064366445,0.0006031116,0.00014418161,0.00059277035,0.0004582688,0.00059788505,0.0013588793],"category_scores_gemma":[0.00029516502,0.00014926885,0.00031079416,0.0004749996,0.00023240744,0.0005856697,0.00032408469,0.0009609515,0.0013486454],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027204122,0.00014372826,0.00032038978,0.015363368,0.00018321657,0.0006090695,0.00013466502,0.00064043346,0.11899852,0.007504862,0.024658585,0.83117104],"study_design_scores_gemma":[0.000049678318,0.00065931404,0.0014250259,0.0007050079,0.00021572754,0.0019470921,0.00004232363,0.00030960128,0.05387116,0.0017783026,0.9389677,0.000029014604],"about_ca_topic_score_codex":0.00021452436,"about_ca_topic_score_gemma":0.00070446066,"teacher_disagreement_score":0.0013588793,"about_ca_system_score_codex":0.00038345862,"about_ca_system_score_gemma":0.00036835708,"threshold_uncertainty_score":0.0045458674},"labels":[],"label_agreement":null},{"id":"W4393097547","doi":"10.21203/rs.3.rs-4127121/v1","title":"Exploring the Structural Diversity of Novel 3-Substituted Coumarins as Potent Inhibitors of Tumor-Associated Carbonic Anhydrases: Expanding the Pharmacological Space for Anticancer Drug Discovery","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Saint Mary's University; Mount Saint Vincent University","funders":"","keywords":"Chemical space; Drug; Drug discovery; Diversity (politics); Computational biology; Chemistry; Pharmacology; Biology; Combinatorial chemistry; Biochemistry; Political science","score_opus":0.10442206298785292,"score_gpt":0.3736710182881024,"score_spread":0.2692489553002495,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4393097547","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97501844,0.00454355,0.014547146,0.00015365647,0.000024431149,0.000084657426,0.0003538429,0.00012681865,0.005147564],"genre_scores_gemma":[0.9897887,0.0023286622,0.0067070555,0.000045724057,0.000009109628,0.000022300621,0.00018816233,0.000009230582,0.0009009936],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999969,0.0000055723535,0.0000021295346,0.000007902966,0.000008624146,0.000006758733],"domain_scores_gemma":[0.99994934,0.000011670243,0.000016439077,0.000006518336,0.0000079867905,0.0000079873535],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000078831414,0.00027816618,0.00020892132,0.0002703219,0.00013275731,0.0002283453,0.00017947268,0.00014590264,0.001462456],"category_scores_gemma":[0.00013707568,0.00009223211,0.0003234368,0.00025171158,0.00012584288,0.00024495667,0.00014996447,0.00029362048,0.0002425462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038127755,0.00016592667,0.002255526,0.0003884003,0.000044009485,0.00046647238,0.00006305907,0.02909829,0.9201629,0.0036521123,0.00030208228,0.04302],"study_design_scores_gemma":[0.00016304039,0.006114718,0.009718815,0.00009254268,0.00023115876,0.0011927637,0.00013365448,0.07378004,0.88145673,0.0027358748,0.02429866,0.00008191363],"about_ca_topic_score_codex":0.0005334548,"about_ca_topic_score_gemma":0.0011970237,"teacher_disagreement_score":0.001462456,"about_ca_system_score_codex":0.00018565982,"about_ca_system_score_gemma":0.0002053336,"threshold_uncertainty_score":0.004892409},"labels":[],"label_agreement":null},{"id":"W4399197233","doi":"10.1093/mtomcs/mfae028","title":"Interaction of carbonic anhydrase I released from red blood cells with human plasma in vitro","year":2024,"lang":"en","type":"article","venue":"Metallomics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"In vitro; Carbonic anhydrase; Human plasma; Chemistry; Carbonic anhydrase II; Biochemistry; Enzyme; Chromatography","score_opus":0.007191166086305618,"score_gpt":0.2209392679474987,"score_spread":0.21374810186119308,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4399197233","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98403096,0.0072592488,0.0052142623,0.00019298126,0.00006724703,0.000091876005,0.00095254544,0.00007515296,0.0021158746],"genre_scores_gemma":[0.9876552,0.0023057526,0.0061456366,0.00009328573,0.00003726591,0.000046389006,0.0015458927,0.000021100606,0.0021494527],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995351,0.00014502194,0.000040265717,0.000114059054,0.00009535463,0.000070245755],"domain_scores_gemma":[0.9998292,0.000069635484,0.000027955917,0.000018836821,0.000035489884,0.00001878734],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045926435,0.00041075278,0.00033782044,0.00013869048,0.00016445166,0.0003282552,0.00024655915,0.0002486669,0.0007203934],"category_scores_gemma":[0.0003880724,0.00013502766,0.00030875576,0.00026988026,0.00016282177,0.00014411139,0.00021850983,0.00035925102,0.0002766465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020354627,0.000051910658,0.0005466886,0.00013183182,0.00003478396,0.00011053392,0.00012559559,0.00018504911,0.99623764,0.000047436926,0.00014260891,0.0021822848],"study_design_scores_gemma":[0.000025555604,0.0004678263,0.0050417664,0.000014610553,0.000029089466,0.0001465407,0.00006099435,0.0019357112,0.9892868,0.000037537626,0.0029394932,0.000013993197],"about_ca_topic_score_codex":0.0036705013,"about_ca_topic_score_gemma":0.002875157,"teacher_disagreement_score":0.0036705013,"about_ca_system_score_codex":0.00021649576,"about_ca_system_score_gemma":0.000288038,"threshold_uncertainty_score":0.0072982907},"labels":[],"label_agreement":null},{"id":"W4402225146","doi":"10.1080/17568919.2024.2379232","title":"Novel 3-substituted coumarins inspire a custom pharmacology prediction pipeline: an anticancer discovery adventure","year":2024,"lang":"en","type":"article","venue":"Future Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Saint Mary's University; Mount Saint Vincent University","funders":"","keywords":"Chemical space; Pipeline (software); Molecular Pharmacology; Drug discovery; Pharmacology; Computational biology; Chemistry; Computer science; Medicine; Biology; Biochemistry; Programming language","score_opus":0.006885354333878468,"score_gpt":0.26060715945820057,"score_spread":0.2537218051243221,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402225146","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.48489636,0.017123139,0.47468823,0.0011553065,0.00010525076,0.0003342614,0.0025418745,0.004188231,0.014967326],"genre_scores_gemma":[0.86835444,0.008308954,0.118460745,0.00018007464,0.000034430243,0.00008366314,0.0017658647,0.00012667682,0.0026850703],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9999114,0.00001801153,0.0000050713716,0.00002501259,0.000027808985,0.000012610581],"domain_scores_gemma":[0.99988985,0.000031796662,0.000029973442,0.000020032036,0.000017967976,0.000010434452],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026755882,0.00066276785,0.0005012842,0.0003503805,0.00016121143,0.0006397311,0.00039048304,0.0002765291,0.0024170647],"category_scores_gemma":[0.00038158934,0.00019644489,0.0007144977,0.00032758838,0.00018686094,0.00057848997,0.00031563934,0.00064025505,0.0009105804],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00065852876,0.0002888651,0.005889389,0.0010613571,0.00017909377,0.00073833246,0.00007663936,0.18947159,0.5604848,0.011751394,0.0015452305,0.22785479],"study_design_scores_gemma":[0.00014682671,0.0025900495,0.0043396284,0.00013420652,0.0003550895,0.0014218609,0.000085868574,0.4416762,0.48722878,0.010264811,0.051617935,0.0001386973],"about_ca_topic_score_codex":0.00088334124,"about_ca_topic_score_gemma":0.0014540303,"teacher_disagreement_score":0.0024170647,"about_ca_system_score_codex":0.00031961317,"about_ca_system_score_gemma":0.0005130199,"threshold_uncertainty_score":0.008085847},"labels":[],"label_agreement":null},{"id":"W4407786256","doi":"10.56042/ijc.v64i2.15602","title":"Synthesis and characterization of (E)-N-carbamimidoyl -4 and (E)-4- benzenesulfonamides; biological study, DFT, molecular docking, and ADMET predictions","year":2025,"lang":"en","type":"article","venue":"Indian Journal of Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Concordia University","funders":"Tertiary Education Trust Fund; Covenant University","keywords":"Docking (animal); Chemistry; Stereochemistry; Computational chemistry; Combinatorial chemistry; Computational biology; Biology; Medicine","score_opus":0.0058457389662894595,"score_gpt":0.22360751487485803,"score_spread":0.21776177590856857,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4407786256","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95095986,0.009395872,0.029282,0.0002278342,0.00005414412,0.00040108708,0.0017368925,0.00027224634,0.007670037],"genre_scores_gemma":[0.96470135,0.004727789,0.022953719,0.00009551402,0.000016337079,0.0002917193,0.0011205141,0.000033219374,0.0060597705],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999391,0.000012235178,0.00000548243,0.000012279176,0.00001996697,0.000010882607],"domain_scores_gemma":[0.9999225,0.000007695043,0.000023648983,0.00000715938,0.000022125496,0.000016899954],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025974822,0.00038347012,0.00031984973,0.00021967883,0.00011654101,0.00013853583,0.00033694285,0.0001993416,0.0013404557],"category_scores_gemma":[0.00024032095,0.000118985234,0.00015864545,0.00024326464,0.00011120459,0.00018569524,0.00014175317,0.0002932495,0.0006392804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025322163,0.00013845447,0.00023646581,0.00032095192,0.000019653995,0.00012451834,0.000043719385,0.002873538,0.9811137,0.00071819883,0.00036477827,0.013792904],"study_design_scores_gemma":[0.000054674325,0.0011927437,0.0011533439,0.000013505794,0.000024481178,0.00018889798,0.000019346175,0.0061882976,0.9780172,0.000107760345,0.013018501,0.000021224369],"about_ca_topic_score_codex":0.00080075476,"about_ca_topic_score_gemma":0.0015308055,"teacher_disagreement_score":0.0013404557,"about_ca_system_score_codex":0.00031655972,"about_ca_system_score_gemma":0.0002690427,"threshold_uncertainty_score":0.0044842362},"labels":[],"label_agreement":null},{"id":"W4411657075","doi":"10.51847/g2adv8v","title":"10.51847/G2aDV8V","year":2000,"lang":"en","type":"article","venue":"Time to knit","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; Cairo University","keywords":"Sulfonamide; Thiouracil; Combinatorial chemistry; Chemistry; Stereochemistry; Medicine; Internal medicine","score_opus":0.004020834442012957,"score_gpt":0.17738778075502828,"score_spread":0.17336694631301533,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4411657075","genre_codex":"other","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":"other","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.009634817,0.0014609934,0.0054755104,0.0013370254,0.0008037882,0.00012013935,0.003170267,0.0050232215,0.97297406],"genre_scores_gemma":[0.016961563,0.00037052494,0.0027727955,0.00038962773,0.00007812645,0.00006900674,0.0038949978,0.0008260771,0.9746373],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99976546,0.000017204677,0.00000973427,0.0000825926,0.00007204769,0.000052850497],"domain_scores_gemma":[0.9997234,0.000027718823,0.000019778074,0.00007437989,0.00004424853,0.000110552726],"candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003457552,0.0012909127,0.0005137809,0.001498924,0.00069794565,0.001723704,0.0010464974,0.001837786,0.88912225],"category_scores_gemma":[0.00025252285,0.0003972228,0.00045795282,0.0011471731,0.0007035446,0.0008214571,0.001796274,0.0014013788,0.90135574],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00054541876,0.00046575099,0.0013882059,0.00034276524,0.000038103808,0.0004958856,0.000116302675,0.00068259187,0.07358731,0.012002367,0.16616338,0.7441719],"study_design_scores_gemma":[0.000073415766,0.00013389175,0.0020514803,0.00010217509,0.000012064068,0.000632316,0.000076055374,0.0006000452,0.008267726,0.001950043,0.9860865,0.0000143945545],"about_ca_topic_score_codex":0.0012598411,"about_ca_topic_score_gemma":0.0009901546,"teacher_disagreement_score":0.11087775,"about_ca_system_score_codex":0.00082104234,"about_ca_system_score_gemma":0.00037527524,"threshold_uncertainty_score":0.1581536},"labels":[],"label_agreement":null},{"id":"W4411697216","doi":"10.26434/chemrxiv-2025-sh383","title":"The structural basis for the selectivity of sulfonamide-based inhibitors of carbonic anhydrase isoforms IX and XII: A comprehensive review of the crystallographic data","year":2025,"lang":"en","type":"review","venue":"ChemRxiv","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Universiti Malaya; Alliance de recherche numérique du Canada; Government of Ontario; University of Windsor","keywords":"Sulfonamide; Carbonic anhydrase; Gene isoform; Chemistry; Selectivity; Stereochemistry; Enzyme; Combinatorial chemistry; Biochemistry; Gene","score_opus":0.026922313220371367,"score_gpt":0.3016540714030657,"score_spread":0.27473175818269435,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4411697216","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.003174678,0.9915735,0.0010661985,0.00046773325,0.00014302245,0.000035992533,0.00021792145,0.000041461026,0.003279515],"genre_scores_gemma":[0.0074639833,0.9898287,0.0010909317,0.00021472677,0.00007850885,0.000027101882,0.00033118966,0.0000068752606,0.00095793704],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998148,0.00002285258,0.000028958128,0.0000315799,0.00007767081,0.00002410137],"domain_scores_gemma":[0.9998311,0.000048542937,0.00003641615,0.0000078379,0.00006173135,0.000014308747],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005436865,0.0009144542,0.0013969277,0.0013113855,0.00022844589,0.00090390793,0.00075833965,0.0006309518,0.0013101702],"category_scores_gemma":[0.0006093276,0.00050759304,0.0008425456,0.0014589209,0.00035559808,0.0007351219,0.0003816201,0.0014559182,0.0008251471],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00058051135,0.0002691305,0.0010527348,0.047027767,0.00073545385,0.00096770865,0.00043232774,0.0077914866,0.05851941,0.019139314,0.054719165,0.80876493],"study_design_scores_gemma":[0.00013777535,0.0005691049,0.0020435655,0.0030636168,0.00064091507,0.0016389596,0.00011487445,0.0016021081,0.017285336,0.003040441,0.9697546,0.00010876614],"about_ca_topic_score_codex":0.0024875859,"about_ca_topic_score_gemma":0.0028488734,"teacher_disagreement_score":0.0024875859,"about_ca_system_score_codex":0.000846752,"about_ca_system_score_gemma":0.0014182546,"threshold_uncertainty_score":0.006143689},"labels":[],"label_agreement":null},{"id":"W4411957172","doi":"10.1016/j.jcoa.2025.100236","title":"Metabolite patterns of the carbonic anhydrase inhibitors brinzolamide and dorzolamide: potential markers for the route of application","year":2025,"lang":"en","type":"article","venue":"Journal of Chromatography Open","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Manfred Donike Institut für Dopinganalytik; Bundesministerium des Innern, für Bau und Heimat; World Anti-Doping Agency","keywords":"Dorzolamide; Carbonic anhydrase; Metabolite; Chemistry; Pharmacology; Biochemistry; Enzyme; Biology; Neuroscience","score_opus":0.003673023088428789,"score_gpt":0.24021282422571968,"score_spread":0.2365398011372909,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4411957172","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9873882,0.00416432,0.0060538314,0.000090739515,0.000036814872,0.00008927456,0.0007045069,0.000053432766,0.0014189074],"genre_scores_gemma":[0.9891237,0.0018356107,0.0060464544,0.00014115845,0.000018846524,0.000074027266,0.00056175713,0.000024087976,0.0021743292],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997172,0.000043622204,0.0000141741075,0.00008699784,0.00010065513,0.000037300444],"domain_scores_gemma":[0.99967563,0.000047329257,0.00014483607,0.000018405362,0.000079123376,0.000034768185],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021392731,0.0003796085,0.0002533928,0.00040916415,0.000100319005,0.00041142528,0.00015767092,0.00052994955,0.00058339804],"category_scores_gemma":[0.00039633387,0.0001967403,0.00030502566,0.0001939378,0.00023961831,0.00023445215,0.00012289891,0.00042678416,0.00020975785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005334128,0.000034564575,0.0058783484,0.00006519515,0.000030546737,0.00009024627,0.000050823888,0.000043551023,0.9874537,0.00003759478,0.000038315142,0.005743628],"study_design_scores_gemma":[0.00002524226,0.0030156584,0.118321106,0.000027745551,0.00012313087,0.0009309069,0.00014930968,0.0012190376,0.8736544,0.00008046284,0.0024195646,0.00003349859],"about_ca_topic_score_codex":0.0014048946,"about_ca_topic_score_gemma":0.0017120595,"teacher_disagreement_score":0.0014048946,"about_ca_system_score_codex":0.0002476632,"about_ca_system_score_gemma":0.00030322451,"threshold_uncertainty_score":0.0027934313},"labels":[],"label_agreement":null},{"id":"W4412599464","doi":"10.1016/j.rechem.2025.102556","title":"Pursing Quinoline-8-Sulfonamide derivatives for the identification of potent NPPs inhibitors: In silico molecular docking, molecular dynamics simulations and density field theory (DFT) studies","year":2025,"lang":"en","type":"article","venue":"Results in Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Fonds de recherche du Québec; Deanship of Scientific Research, King Saud University; Natural Sciences and Engineering Research Council of Canada; Higher Education Commision, Pakistan; Deanship of Scientific Research, Imam Mohammed Ibn Saud Islamic University","keywords":"In silico; Quinoline; Sulfonamide; Molecular dynamics; Docking (animal); Identification (biology); Chemistry; Computational chemistry; Computational biology; Combinatorial chemistry; Stereochemistry; Biology; Medicine; Organic chemistry; Biochemistry","score_opus":0.009243819133136651,"score_gpt":0.2983994078789908,"score_spread":0.2891555887458541,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412599464","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91968894,0.016262261,0.04334301,0.00095338776,0.00018730471,0.00025503358,0.0014867802,0.000679155,0.01714416],"genre_scores_gemma":[0.9630306,0.006385931,0.026813345,0.00018398688,0.000025684103,0.0002729722,0.0010327406,0.000062218605,0.0021925098],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99986506,0.000040858296,0.0000072076205,0.000021392694,0.00003819473,0.000027346621],"domain_scores_gemma":[0.99985635,0.00007219476,0.00002218829,0.00000709752,0.00002606289,0.000016046457],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036051084,0.0009957165,0.0013331865,0.00043492558,0.00032173825,0.0006562465,0.0006956371,0.0006257709,0.0019071201],"category_scores_gemma":[0.0005696711,0.0003274594,0.0009210057,0.00058075803,0.000222941,0.0004544021,0.0003950636,0.0007308972,0.00037819362],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00067483506,0.0004993373,0.0019807608,0.0011300024,0.00029739065,0.00077348715,0.00010318243,0.9205076,0.040733382,0.007101249,0.002211373,0.023987427],"study_design_scores_gemma":[0.00011853418,0.0005088673,0.00034552856,0.00003423967,0.000096277035,0.00006083582,0.00006172935,0.9882515,0.00728816,0.0007917513,0.0024151267,0.000027530246],"about_ca_topic_score_codex":0.0042004045,"about_ca_topic_score_gemma":0.0068377233,"teacher_disagreement_score":0.0042004045,"about_ca_system_score_codex":0.00048837264,"about_ca_system_score_gemma":0.0006743261,"threshold_uncertainty_score":0.008351922},"labels":[],"label_agreement":null},{"id":"W4412695782","doi":"10.1158/0008-5472.can-24-3894","title":"Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiotherapy","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre; University of Toronto; Hamilton Health Sciences; Hospital for Sick Children; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; All of Us Research Program; Stand Up To Cancer; Cancer Prevention and Research Institute of Texas; Stand Up To Cancer Canada; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"Medulloblastoma; Radioresistance; Medicine; Radiation therapy; Oncology; Acetazolamide; Internal medicine; Radiosensitizer; Cancer research","score_opus":0.020477693055651332,"score_gpt":0.36564725674092896,"score_spread":0.3451695636852776,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412695782","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9957558,0.0015214471,0.0008014061,0.00017624766,0.000027309865,0.00006245879,0.00028349695,0.00012585851,0.0012460311],"genre_scores_gemma":[0.99713576,0.0010699498,0.000594272,0.00008688665,0.000011282309,0.000026119395,0.00035930905,0.00001849218,0.00069804967],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999435,0.000005078179,0.000003646589,0.000009848853,0.000019474839,0.000018471053],"domain_scores_gemma":[0.9999218,0.000009805603,0.000035140205,0.000008695273,0.000008911209,0.000015625885],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008276981,0.00021586686,0.00021279806,0.00020334708,0.00011210393,0.00026185732,0.00015182572,0.00018580612,0.0010338436],"category_scores_gemma":[0.00018094768,0.00007631257,0.0002491731,0.00016987305,0.0002077323,0.000107614505,0.000112620364,0.00044415105,0.00018528987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00052043446,0.00008908378,0.011461067,0.00008518221,0.000045777222,0.00021798039,0.00003840148,0.0002898462,0.97578126,0.000103014085,0.0006633726,0.010704443],"study_design_scores_gemma":[0.00017751551,0.002845839,0.23120978,0.000038177383,0.00016107022,0.0031680258,0.00015730991,0.0028912663,0.7499082,0.00029663809,0.009126624,0.00001952744],"about_ca_topic_score_codex":0.0029503272,"about_ca_topic_score_gemma":0.0069170487,"teacher_disagreement_score":0.0029503272,"about_ca_system_score_codex":0.0004909465,"about_ca_system_score_gemma":0.0003312979,"threshold_uncertainty_score":0.0058663487},"labels":[],"label_agreement":null},{"id":"W4413808671","doi":"10.1021/acs.jmedchem.5c01584","title":"Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"Horizon 2020 Framework Programme; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca; Purdue Institute for Drug Discovery; Purdue University","keywords":"Chemistry; Acetazolamide; In vivo; Carbonic anhydrase; Vancomycin; Microbiology; Antibiotics; Enterococcus; Vancomycin-Resistant Enterococci; Pharmacology; Enzyme; Bacteria; Biochemistry; Staphylococcus aureus; Internal medicine; Medicine; Biology","score_opus":0.006034865627572108,"score_gpt":0.25047697871301394,"score_spread":0.24444211308544184,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4413808671","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96565896,0.007607511,0.014681827,0.0005165761,0.00015807372,0.0006455912,0.0014369001,0.0002900945,0.0090043945],"genre_scores_gemma":[0.98040366,0.004761284,0.008210348,0.0002150542,0.000019620076,0.00014328418,0.0009969529,0.000035622095,0.005214151],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998122,0.000043263568,0.000014226797,0.000031801956,0.00004803367,0.000050569623],"domain_scores_gemma":[0.9999187,0.000011317812,0.000019321846,0.000007363573,0.000021962696,0.000021381094],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037846848,0.00072749524,0.0006255166,0.00039015617,0.00025816562,0.0004983297,0.0003739152,0.00027787275,0.0023728576],"category_scores_gemma":[0.00029714854,0.00017668112,0.0003346268,0.000449051,0.00021726212,0.0002453089,0.0004472199,0.00074109086,0.00041983795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021207263,0.0019296196,0.001498135,0.0006768574,0.00015389036,0.0015041478,0.00025727143,0.023570288,0.9104888,0.0031963643,0.0028774836,0.051726487],"study_design_scores_gemma":[0.0018786994,0.029291833,0.0062854597,0.00016727595,0.0004259975,0.0017919504,0.00024658936,0.02600763,0.89913136,0.0015560897,0.033074617,0.00014248079],"about_ca_topic_score_codex":0.0013052847,"about_ca_topic_score_gemma":0.0059275697,"teacher_disagreement_score":0.0023728576,"about_ca_system_score_codex":0.0004470403,"about_ca_system_score_gemma":0.0007613334,"threshold_uncertainty_score":0.007938027},"labels":[],"label_agreement":null},{"id":"W4413922863","doi":"10.1016/j.ejmech.2025.118107","title":"Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SignalChem (Canada); Spinal Cord Injury BC","funders":"European Synchrotron Radiation Facility","keywords":"Chemistry; Carbonic anhydrase; Programmed cell death; Dual (grammatical number); Peroxidase; Glutathione peroxidase; Glutathione; Tumor cells; Biochemistry; Enzyme; GPX4; Cancer research; Apoptosis","score_opus":0.016032975110936768,"score_gpt":0.25686171200440433,"score_spread":0.24082873689346757,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4413922863","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97138613,0.003689459,0.020176766,0.00038878308,0.0001277875,0.00010407922,0.00014463231,0.00026189955,0.0037203485],"genre_scores_gemma":[0.9923995,0.0010699566,0.0035976635,0.000052520933,0.000008338836,0.000025772308,0.00007472094,0.000010919292,0.0027607258],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994147,0.000007989249,0.000002903172,0.000012471896,0.00001536771,0.000019887182],"domain_scores_gemma":[0.99998415,0.0000023866833,0.000004532054,0.0000022201548,0.0000025930015,0.0000040892105],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120651595,0.00032415913,0.00026316557,0.00018225171,0.00011940726,0.0001726015,0.0003288472,0.0003013053,0.0006052534],"category_scores_gemma":[0.00004937412,0.00011042633,0.00020610879,0.00010908408,0.00014894467,0.00016144263,0.00016769783,0.00052017235,0.00014043256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001733872,0.000045552824,0.000043693693,0.000040817093,0.000013024295,0.00006914365,0.000009948025,0.00022145537,0.99492365,0.000402852,0.000118730546,0.003937752],"study_design_scores_gemma":[0.00004144945,0.00044739907,0.00030673796,0.0000027871015,0.000022752574,0.00016880494,0.000005228109,0.0013620369,0.9950152,0.00009617656,0.0025264479,0.0000049279342],"about_ca_topic_score_codex":0.0003392059,"about_ca_topic_score_gemma":0.00085370435,"teacher_disagreement_score":0.0006052534,"about_ca_system_score_codex":0.00025805167,"about_ca_system_score_gemma":0.00019316141,"threshold_uncertainty_score":0.0020247698},"labels":[],"label_agreement":null},{"id":"W4415167706","doi":"10.26434/chemrxiv-2025-sh383-v2","title":"The structural basis for the selectivity of sulfonamide-based inhibitors of carbonic anhydrase isoforms IX and XII: A comprehensive review of the crystallographic data","year":2025,"lang":"en","type":"review","venue":"ChemRxiv","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Universiti Malaya","keywords":"Cocrystal; Carbonic anhydrase; Carbonic anhydrase II; Gene isoform; Selectivity; Sulfonamide; Residue (chemistry); Binding site; Protein Data Bank (RCSB PDB)","score_opus":0.026922313220371367,"score_gpt":0.3016540714030657,"score_spread":0.27473175818269435,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4415167706","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.015207831,0.97159857,0.0045628757,0.0010456475,0.00014156855,0.00007919843,0.0006632701,0.000119039316,0.00658193],"genre_scores_gemma":[0.04277464,0.94916487,0.004719625,0.00038024707,0.00011464156,0.000054062228,0.0011038191,0.000019422,0.0016686836],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99981874,0.000019900166,0.000025626481,0.000036585323,0.00007536927,0.000023836215],"domain_scores_gemma":[0.9998555,0.000035788013,0.00003362736,0.0000074192862,0.000055300938,0.000012315478],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006390151,0.0009893662,0.0010647592,0.0009807802,0.0002232043,0.0009376326,0.0008934073,0.00059534324,0.0010649211],"category_scores_gemma":[0.0005567306,0.00049850525,0.00077577645,0.001089194,0.00040576814,0.00077353785,0.00034242842,0.0014642662,0.0005494737],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008734962,0.0002469229,0.003509604,0.030504346,0.0009017024,0.0009289531,0.0003962427,0.016299134,0.16097134,0.023146817,0.033277873,0.7289435],"study_design_scores_gemma":[0.00024491415,0.00091727613,0.007980096,0.0034080374,0.0014033394,0.0022451696,0.00027793675,0.007982335,0.10002963,0.007873786,0.86745405,0.00018324304],"about_ca_topic_score_codex":0.0044936673,"about_ca_topic_score_gemma":0.00521073,"teacher_disagreement_score":0.0044936673,"about_ca_system_score_codex":0.0014473667,"about_ca_system_score_gemma":0.0019242688,"threshold_uncertainty_score":0.010501444},"labels":[],"label_agreement":null},{"id":"W4416889528","doi":"10.1016/j.abb.2025.110682","title":"A comprehensive review of the structural basis for the selectivity of sulfonamide-based inhibitors for carbonic anhydrase isoforms IX and XII over carbonic anhydrase II based on the available high quality crystallographic data","year":2025,"lang":"en","type":"review","venue":"Archives of Biochemistry and Biophysics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor","funders":"Alliance de recherche numérique du Canada; Natural Sciences and Engineering Research Council of Canada; Universiti Malaya; University of Windsor","keywords":"Carbonic anhydrase; Cocrystal; Carbonic anhydrase II; Selectivity; Gene isoform; Sulfonamide; Isozyme; Residue (chemistry)","score_opus":0.02577067482208124,"score_gpt":0.2936433119822606,"score_spread":0.2678726371601794,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4416889528","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.004075498,0.98514116,0.0029015522,0.00056003686,0.00025568772,0.000044212236,0.00062441814,0.00012925793,0.0062682345],"genre_scores_gemma":[0.011869962,0.981268,0.0026923532,0.00041596414,0.00013905947,0.000036062967,0.0009051815,0.000019370667,0.0026540472],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99985063,0.000017891081,0.000026506212,0.000027497172,0.00006120251,0.000016401658],"domain_scores_gemma":[0.9998424,0.000047737005,0.000032043055,0.000007855965,0.000055013745,0.000014814023],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037089663,0.0008333137,0.0008387467,0.0011456322,0.0002111559,0.00066444953,0.00068032026,0.0004123826,0.0035107809],"category_scores_gemma":[0.00048698595,0.00032136973,0.00053858664,0.0013094697,0.00019688932,0.00065613986,0.0002875219,0.0009503016,0.0014305558],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040829828,0.00014525095,0.0006969121,0.039711487,0.00051259645,0.00043644843,0.00012771215,0.003883951,0.073917374,0.0099311955,0.05813572,0.8120931],"study_design_scores_gemma":[0.000041013533,0.00037125277,0.0015409366,0.002052288,0.0004418703,0.00067180715,0.00004274803,0.00091391994,0.017399471,0.0016439282,0.97484064,0.000039998522],"about_ca_topic_score_codex":0.0017026244,"about_ca_topic_score_gemma":0.00290204,"teacher_disagreement_score":0.0035107809,"about_ca_system_score_codex":0.0007745115,"about_ca_system_score_gemma":0.0014978203,"threshold_uncertainty_score":0.011744678},"labels":[],"label_agreement":null},{"id":"W4417297358","doi":"10.1021/acsinfecdis.5c00736","title":"Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in <i> <i>Enterococcus faecium</i> </i> Septicemic Peritonitis Mouse Model While Sparing the Microbiome","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada); Collège Boréal","funders":"Horizon 2020 Framework Programme; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca; Purdue Institute for Drug Discovery","keywords":"Acetazolamide; In vivo; Carbonic anhydrase; Antibiotics; Microbiome; Gut microbiome; Gut flora; Gastrointestinal tract","score_opus":0.006034143450997236,"score_gpt":0.2253233565567682,"score_spread":0.21928921310577096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4417297358","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.982797,0.0049943468,0.0029721104,0.0006909398,0.00017838937,0.00007090293,0.002430937,0.0004491801,0.0054161395],"genre_scores_gemma":[0.9816768,0.004368272,0.0041866,0.00043640455,0.00002335474,0.00008446198,0.003020317,0.00004724275,0.006156524],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988747,0.000011989158,0.00001049969,0.000019927722,0.00004099019,0.000029078848],"domain_scores_gemma":[0.99992716,0.0000076011943,0.000023486746,0.0000053260187,0.000009683101,0.000026795911],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011892261,0.00034080748,0.0002759897,0.00023893664,0.000108406544,0.00019701174,0.00021030437,0.00037985356,0.0017155976],"category_scores_gemma":[0.000101128295,0.000097350545,0.00029226425,0.00015327787,0.00019202929,0.00018775034,0.00010723518,0.0008781395,0.0003503332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043355027,0.00012802052,0.00024656582,0.00013821608,0.000012989023,0.000063736115,0.000008354988,0.00012358293,0.9951309,0.00007078155,0.00049927604,0.0031439841],"study_design_scores_gemma":[0.000049636994,0.0018509373,0.003742187,0.000018035835,0.000029825671,0.00022221587,0.000030912037,0.0009277251,0.9883376,0.000044018194,0.004736172,0.000010821909],"about_ca_topic_score_codex":0.0012124341,"about_ca_topic_score_gemma":0.0022008165,"teacher_disagreement_score":0.0017155976,"about_ca_system_score_codex":0.00019555366,"about_ca_system_score_gemma":0.00033280696,"threshold_uncertainty_score":0.0057392716},"labels":[],"label_agreement":null},{"id":"W6912681108","doi":"10.5281/zenodo.8265007","title":"Sulphonamides Unveiled: A Comprehensive Review of Mechanisms, Applications, and Therapeutic Insights","year":2023,"lang":"en","type":"peer-review","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Kane Biotech (Canada)","funders":"","keywords":"Sulfonamide; Drug; Folic Acid Antagonists; Folic acid; Antimicrobial","score_opus":0.03917023861117868,"score_gpt":0.28175660424376164,"score_spread":0.24258636563258296,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6912681108","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00034505888,0.9965448,0.0002476451,0.0005342519,0.0005009863,0.000010439181,0.00004885083,0.000019384674,0.0017486658],"genre_scores_gemma":[0.0017119518,0.9958942,0.00031419023,0.00021786206,0.00037152634,0.000009279508,0.00008625076,0.000004803538,0.0013899684],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99965596,0.00005101955,0.00005488297,0.00005329301,0.00015256631,0.000032225995],"domain_scores_gemma":[0.99949455,0.00014089525,0.000078440135,0.000016785272,0.00021772434,0.000051719344],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008057703,0.00059569994,0.0008078738,0.0021537042,0.00032084808,0.0013042793,0.00059476105,0.0007292291,0.0061231614],"category_scores_gemma":[0.0010408692,0.00024327807,0.00044732995,0.0019227499,0.0003953514,0.0015271425,0.0006032863,0.0011019149,0.0026830938],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013143734,0.00006421138,0.00021408164,0.020891858,0.000077285185,0.00020203515,0.0000982755,0.00020417996,0.0047106496,0.004030739,0.03408513,0.93529016],"study_design_scores_gemma":[0.000010903963,0.00008459557,0.00048014513,0.0016372199,0.00007559126,0.00064865267,0.00004724704,0.00005607189,0.0012786805,0.0007932923,0.99487454,0.000013152664],"about_ca_topic_score_codex":0.00067540567,"about_ca_topic_score_gemma":0.0011294608,"teacher_disagreement_score":0.0061231614,"about_ca_system_score_codex":0.0006144128,"about_ca_system_score_gemma":0.0016710892,"threshold_uncertainty_score":0.02048397},"labels":[],"label_agreement":null},{"id":"W6927656027","doi":"10.34943/863f9470-4e5c-4627-8230-111a6d737d9e","title":"Tsawwassen - Swartz Bay Ferry Route Fluorometer Deployed 2009-02-05","year":2011,"lang":"en","type":"dataset","venue":"Ocean Networks Canada Society","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Bay; Fluorometer; Estuary; Digital data; Software deployment; Data logger","score_opus":0.007528824320392528,"score_gpt":0.19302972242611718,"score_spread":0.18550089810572465,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6927656027","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0007019016,0.000040393646,0.00011044869,0.000054083248,0.000011874171,0.000008424208,0.99763536,0.000234748,0.0012027571],"genre_scores_gemma":[0.001237094,0.00003573543,0.00032612673,0.000019668727,0.0000030940107,0.000028841183,0.99716264,0.000039339946,0.0011473089],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9992079,0.00008081597,0.000064970096,0.00024981992,0.00027583932,0.00012069355],"domain_scores_gemma":[0.99798214,0.00023983464,0.0002266358,0.00041408697,0.0009372281,0.00019997926],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009859265,0.0012505662,0.0010025707,0.0023982567,0.0007569888,0.0015985911,0.001978337,0.00096936536,0.013669701],"category_scores_gemma":[0.0039979345,0.00041732352,0.0005890802,0.0047112936,0.00034055483,0.00087581103,0.0009392635,0.0012671695,0.022958955],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017410194,0.00004050333,0.008116001,0.00045856478,0.0000608577,0.000049871385,0.000056122833,0.0012884717,0.00042587463,0.0009980567,0.98325413,0.0050775004],"study_design_scores_gemma":[0.00010371781,0.000014903726,0.023728466,0.0001258998,0.00002941778,0.000034982986,0.00011996404,0.0010951322,0.0010507234,0.0006734918,0.9729897,0.000033656637],"about_ca_topic_score_codex":0.22759025,"about_ca_topic_score_gemma":0.35083112,"teacher_disagreement_score":0.22759025,"about_ca_system_score_codex":0.0033741246,"about_ca_system_score_gemma":0.0042311796,"threshold_uncertainty_score":0.4525311},"labels":[],"label_agreement":null},{"id":"W6931580847","doi":"10.5281/zenodo.7420721","title":"Cheer Derby Nashville Nationals 2022 live streaming online Cheer &amp; Dance free","year":2022,"lang":"en","type":"other","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Dance; Studio; Doors; Event (particle physics); Upload; The Internet","score_opus":0.02223806032820982,"score_gpt":0.24422232063629615,"score_spread":0.22198426030808632,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6931580847","genre_codex":"dataset","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00042453472,0.00009073551,0.00024998057,0.00043317492,0.000341953,0.00005127368,0.991591,0.0023729953,0.004444258],"genre_scores_gemma":[0.00083280896,0.00010206372,0.0007497121,0.00024406485,0.00008024286,0.00014022765,0.99110353,0.00037420404,0.006373227],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9990133,0.00018480298,0.00007220988,0.00028876215,0.0002622398,0.00017875509],"domain_scores_gemma":[0.997532,0.00029959608,0.0001250436,0.00070546864,0.00089104864,0.00044672712],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0014181229,0.0017789121,0.0011361501,0.0026671498,0.0012000712,0.003123736,0.0022137137,0.001460735,0.12593156],"category_scores_gemma":[0.0062719914,0.0005936026,0.0011238807,0.0034346143,0.0002865493,0.0027001926,0.0032133732,0.0015351452,0.20986907],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000029939443,0.000008903296,0.00041417763,0.00008569541,0.00000705722,0.0000063632024,0.000011577787,0.000031678646,0.00006284072,0.00012374726,0.99633175,0.0028862946],"study_design_scores_gemma":[0.000072017654,0.000021298754,0.006853477,0.00023443058,0.000013822932,0.000031424934,0.0001712385,0.00059094414,0.00027801382,0.000702809,0.99099404,0.00003634672],"about_ca_topic_score_codex":0.04631806,"about_ca_topic_score_gemma":0.097458184,"teacher_disagreement_score":0.87406844,"about_ca_system_score_codex":0.0013516292,"about_ca_system_score_gemma":0.001967634,"threshold_uncertainty_score":0.42128307},"labels":[],"label_agreement":null},{"id":"W6996072939","doi":"","title":"Press Release (1961-01-05) More information from the Seaway Institute","year":2018,"lang":"en","type":"other","venue":"University of Minnesota Digital Conservancy (University of Minnesota)","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Lawrence Seaway Management","funders":"","keywords":"Prosperity; Press release; Prime minister; Prime (order theory)","score_opus":0.00877165306362688,"score_gpt":0.1755590048323921,"score_spread":0.16678735176876522,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6996072939","genre_codex":"other","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":"other","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000704076,0.00225514,0.0006782472,0.0024496047,0.0029624267,0.00013399748,0.034544684,0.0022607688,0.95401096],"genre_scores_gemma":[0.00076142984,0.00039494055,0.0001442432,0.00014899352,0.00014591929,0.000019761894,0.003999031,0.00027569983,0.99411005],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9995235,0.00002083083,0.000031565614,0.0000719172,0.0002912461,0.000060976578],"domain_scores_gemma":[0.99885285,0.00015089,0.00007362746,0.00012832227,0.0005773315,0.00021691287],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00067553605,0.000991137,0.00055745884,0.002425378,0.00088286534,0.0034103747,0.000782502,0.0012220808,0.7482543],"category_scores_gemma":[0.0022076303,0.00047060748,0.0004030579,0.0030144306,0.00037038888,0.0017644472,0.0008963725,0.0014487905,0.64794797],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000061252314,0.000022022125,0.00016455718,0.00010164522,0.0000021975789,0.00003799751,0.000025573729,0.000047895213,0.00026790038,0.0016672645,0.9492077,0.048393995],"study_design_scores_gemma":[0.000006653215,0.000009434426,0.0007395971,0.00004065693,8.844632e-7,0.000017152463,0.000013495118,0.000017963426,0.00013289666,0.00014916687,0.9988686,0.0000036609667],"about_ca_topic_score_codex":0.015459633,"about_ca_topic_score_gemma":0.031997446,"teacher_disagreement_score":0.7482543,"about_ca_system_score_codex":0.001614395,"about_ca_system_score_gemma":0.0017007985,"threshold_uncertainty_score":0.35908467},"labels":[],"label_agreement":null},{"id":"W7066557077","doi":"","title":"Identification of a Carboxysomal Î³-Carbonic Anhydrase in the Mesophilic Cyanobacterium Anabaena sp. PCC7120","year":2010,"lang":"en","type":"dissertation","venue":"Library and Archives Canada (Government of Canada)","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Anabaena; Enzyme; Peptide sequence; Thioredoxin; Methanosarcina barkeri; Escherichia coli; Cysteine; Phosphofructokinase 2","score_opus":0.0018938515948339486,"score_gpt":0.15233929232056165,"score_spread":0.15044544072572769,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7066557077","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99452966,0.0009622144,0.0013748998,0.00015181491,0.00001774137,0.000036711754,0.0013031791,0.000038612452,0.0015850503],"genre_scores_gemma":[0.98686975,0.0009613578,0.0035809688,0.00008896538,0.000015065445,0.000029074878,0.0048728767,0.000022005761,0.003559963],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998795,0.000007717038,0.00000930912,0.000029048071,0.000053408985,0.000020993935],"domain_scores_gemma":[0.9998111,0.000016866628,0.000040371826,0.000016571852,0.000056809793,0.00005816504],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009370354,0.0002508314,0.00021648749,0.000478019,0.00028804896,0.00041757984,0.00020809688,0.0002715551,0.00029146788],"category_scores_gemma":[0.00021908915,0.00014894767,0.00024556607,0.00039586055,0.0001621251,0.00015892221,0.00022747804,0.00019825564,0.00027798087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003275872,0.0000095081805,0.0012358491,0.000027253125,0.0000024013775,0.00009292278,0.00003078903,0.000023739902,0.9973279,0.00002825185,0.000021434127,0.0011671413],"study_design_scores_gemma":[0.00001953553,0.0002679615,0.25193736,0.000023832523,0.00004044225,0.0015058339,0.00037050876,0.0009200998,0.7383751,0.0001533877,0.0063614617,0.000024483561],"about_ca_topic_score_codex":0.01257598,"about_ca_topic_score_gemma":0.013679605,"teacher_disagreement_score":0.01257598,"about_ca_system_score_codex":0.0006390985,"about_ca_system_score_gemma":0.0005709251,"threshold_uncertainty_score":0.025005579},"labels":[],"label_agreement":null},{"id":"W7132919777","doi":"","title":"Identification and initial characterization of carbonic anhydrase deletion mutants of Arabidopsis","year":2004,"lang":"","type":"dissertation","venue":"TSpace","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bibliographical Society of Canada","funders":"","keywords":"Arabidopsis; Carbonic anhydrase; Mutant; Arabidopsis thaliana; Gene isoform; Phylogenetic tree; Identification (biology); Gene; Functional genomics","score_opus":0.009320680786990087,"score_gpt":0.29018334246781946,"score_spread":0.28086266168082935,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7132919777","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98768383,0.00047351426,0.0072514527,0.0001393091,0.00002221965,0.00011977306,0.0022722553,0.00014758116,0.0018899522],"genre_scores_gemma":[0.97925925,0.00050963403,0.010155616,0.0000825626,0.000010328217,0.0000889879,0.0037997004,0.00014831749,0.0059456555],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990284,0.00000653128,0.000011650797,0.00002948218,0.00003369293,0.000015726198],"domain_scores_gemma":[0.99982965,0.00002942974,0.000034822227,0.00001536406,0.000030201867,0.000060583414],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010918545,0.00054127903,0.00024524645,0.00038475744,0.00020864063,0.00028558326,0.00032621334,0.00028120252,0.0007694868],"category_scores_gemma":[0.00019098773,0.0001906915,0.00021989424,0.00018171327,0.00018331657,0.00013990489,0.00020601468,0.00059056125,0.00042858435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000020877853,0.000010835286,0.00019096147,0.000010349086,0.0000012426017,0.00009236496,0.000014188324,0.000027713688,0.9990121,0.00004517369,0.000014250391,0.0005599737],"study_design_scores_gemma":[0.000026723092,0.00015815532,0.028057728,0.000008887515,0.000023144605,0.0012268983,0.00007082229,0.0010472272,0.9657282,0.00009406816,0.0035452708,0.000012940721],"about_ca_topic_score_codex":0.0022273944,"about_ca_topic_score_gemma":0.003795312,"teacher_disagreement_score":0.0022273944,"about_ca_system_score_codex":0.00036030382,"about_ca_system_score_gemma":0.0002732057,"threshold_uncertainty_score":0.004428804},"labels":[],"label_agreement":null},{"id":"W799570093","doi":"10.1016/j.humpath.2015.06.017","title":"Sinonasal renal cell–like adenocarcinomas: robust carbonic anhydrase expression","year":2015,"lang":"en","type":"article","venue":"Human Pathology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Carbonic anhydrase; Pathology; Carbonic anhydrase II; Clear cell; Cytoplasm; Clear cell carcinoma; Cell; Adenocarcinoma; Enzyme; Biology; Renal cell carcinoma; Chemistry; Cancer research; Carcinoma; Medicine; Cell biology; Biochemistry; Internal medicine; Cancer","score_opus":0.03132648957804957,"score_gpt":0.24421218342985318,"score_spread":0.21288569385180361,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W799570093","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98459435,0.0019126569,0.0039628847,0.00026607251,0.000052323427,0.000043538326,0.00065205764,0.0001890261,0.008327015],"genre_scores_gemma":[0.9955179,0.00050330505,0.0012161563,0.000032839645,0.000008390854,0.000010976022,0.0003167154,0.000024699373,0.0023689508],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9998535,0.000014498976,0.00001804604,0.000026510357,0.00005373585,0.000033668624],"domain_scores_gemma":[0.99979824,0.00004222134,0.000035947895,0.00004673525,0.00002465101,0.000052133262],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018190552,0.0002899645,0.00027648403,0.0003143534,0.00021667438,0.00042693128,0.00017169888,0.0002578586,0.0014046825],"category_scores_gemma":[0.00025852918,0.00018968467,0.00018289442,0.0003466739,0.00042785125,0.00015963054,0.0002047426,0.00042250447,0.00055253186],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016723426,0.000023637818,0.0024420351,0.00003754743,0.000012251869,0.0021585522,0.000037739854,0.00008131256,0.9917408,0.00041480694,0.00011496561,0.0027689913],"study_design_scores_gemma":[0.000019799483,0.00022248072,0.027837357,0.0000036260888,0.000040582992,0.010215845,0.000111803885,0.0006460311,0.9547203,0.00027489293,0.0058977227,0.000009468113],"about_ca_topic_score_codex":0.0026854288,"about_ca_topic_score_gemma":0.0040142303,"teacher_disagreement_score":0.0026854288,"about_ca_system_score_codex":0.0002813004,"about_ca_system_score_gemma":0.00046123748,"threshold_uncertainty_score":0.0053396225},"labels":[],"label_agreement":null}]}