{"meta":{"query_hash":"a3a05dfb0c8e","filters":{"topic":"Histone Deacetylase Inhibitors Research"},"cohort_total":686,"direct_labels_cover":1,"predictions_cover":686,"exported":686,"export_cap":100000,"truncated":false,"label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"permalink":"https://metacan.xera.ac/q/a3a05dfb0c8e","api":"https://metacan.xera.ac/api/v1/cohort?topic=Histone+Deacetylase+Inhibitors+Research"},"results":[{"id":"W1484277267","doi":"10.1111/jcmm.12595","title":"Histone deacetylase 5 regulates the inflammatory response of macrophages","year":2015,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer; Deutsche Forschungsgemeinschaft","keywords":"Histone deacetylase 5; Histone deacetylase; Biology; Cell biology; Chromatin immunoprecipitation; Transcription factor; Cytokine; Tumor necrosis factor alpha; Histone; Immunology; Gene expression; Biochemistry; Promoter","score_opus":0.011135553014746053,"score_gpt":0.28364821264344636,"score_spread":0.2725126596287003,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1484277267","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94750154,0.04117745,0.005367037,0.00041506955,0.00015793473,0.00005384149,0.0006991973,0.0001266925,0.004501376],"genre_scores_gemma":[0.9900064,0.005571744,0.0013482664,0.00013052636,0.00002884758,0.000020268897,0.0004317712,0.000009590203,0.002452608],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998925,0.000019333487,0.000008779618,0.000023313343,0.000023396133,0.000032627053],"domain_scores_gemma":[0.9999647,0.0000029717532,0.000012066172,0.0000025943139,0.000007759082,0.000009950638],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014330495,0.0002447195,0.0002056965,0.00017965675,0.00013863917,0.00023091433,0.00013046876,0.00018513306,0.0011548486],"category_scores_gemma":[0.00006889395,0.00010966701,0.00030927427,0.00012977913,0.00016108282,0.00013183037,0.0001758262,0.0002548312,0.00032596744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032474461,0.000030575688,0.0017240241,0.00014168816,0.000026759231,0.000091932816,0.000026988611,0.000056281235,0.99165064,0.00017230863,0.00015201197,0.0056021307],"study_design_scores_gemma":[0.00006805285,0.00063695526,0.065276004,0.000044375327,0.00011530981,0.00057429256,0.000173783,0.0008713925,0.9172774,0.00030638283,0.014641702,0.000014396519],"about_ca_topic_score_codex":0.0005879648,"about_ca_topic_score_gemma":0.0010181982,"teacher_disagreement_score":0.0011548486,"about_ca_system_score_codex":0.00027618872,"about_ca_system_score_gemma":0.00019219414,"threshold_uncertainty_score":0.0038633347},"labels":[],"label_agreement":null},{"id":"W1486094676","doi":"10.25011/cim.v36i2.19571","title":"HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9","year":2013,"lang":"en","type":"article","venue":"Clinical and investigative medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Trichostatin A; Histone deacetylase 2; Downregulation and upregulation; Western blot; Cancer research; Matrix metalloproteinase; Small interfering RNA; Chemistry; Transfection; Cell migration; Cell; Metastasis; TIMP1; Cell culture; Histone deacetylase; Cancer; Biology; Medicine; Histone; Gene expression; Internal medicine","score_opus":0.0857403770936628,"score_gpt":0.34313948730616767,"score_spread":0.25739911021250483,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1486094676","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9876872,0.006035989,0.001730474,0.00029987734,0.00013236719,0.000080953796,0.0008010697,0.00019086777,0.0030412225],"genre_scores_gemma":[0.9916284,0.0028793563,0.0009371528,0.00012663924,0.000029325056,0.000075188866,0.0011482423,0.000015423713,0.0031602243],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987555,0.000016683032,0.000013943398,0.0000131310035,0.00003780534,0.000042936117],"domain_scores_gemma":[0.99994445,0.000005702367,0.00001134276,0.000007275363,0.0000121784105,0.000019049448],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012404686,0.00040924546,0.00044577388,0.00023770847,0.00018459438,0.00024985423,0.00020098059,0.00021608226,0.0019001692],"category_scores_gemma":[0.0001037585,0.00011147701,0.0005424938,0.000217,0.00022300603,0.00012978357,0.00015430569,0.00064858433,0.00040785724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044321158,0.00015442725,0.0008597864,0.00015900114,0.00003554446,0.00015602961,0.000010877314,0.00008604661,0.99471164,0.000051785883,0.00032615144,0.0030053973],"study_design_scores_gemma":[0.00016496314,0.0013125464,0.01904355,0.000016198775,0.00012619837,0.0005071197,0.000067968766,0.0014142493,0.9727409,0.000030927004,0.0045678657,0.0000075263292],"about_ca_topic_score_codex":0.0011397484,"about_ca_topic_score_gemma":0.0026945947,"teacher_disagreement_score":0.0019001692,"about_ca_system_score_codex":0.00029939646,"about_ca_system_score_gemma":0.00039129372,"threshold_uncertainty_score":0.006356716},"labels":[],"label_agreement":null},{"id":"W1492214690","doi":"10.1186/ar1781","title":"Histone deacetylases--a new target for suppression of cartilage degradation?","year":2005,"lang":"en","type":"letter","venue":"Arthritis Research & Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"","keywords":"Aggrecan; Oncostatin M; ADAMTS; Matrix metalloproteinase; Trichostatin A; Metalloproteinase; Cartilage; Cancer research; Chemistry; Histone deacetylase; Cell biology; Thrombospondin; Histone; Medicine; Immunology; Biochemistry; Inflammation; Biology; Osteoarthritis; Interleukin 6; Pathology; Anatomy; Articular cartilage","score_opus":0.04246406934857222,"score_gpt":0.36464806081112233,"score_spread":0.3221839914625501,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1492214690","genre_codex":"review","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"commentary","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.013173905,0.5695482,0.005102734,0.37508842,0.021657182,0.00010506788,0.0001774466,0.00023925577,0.014907829],"genre_scores_gemma":[0.16627657,0.48165807,0.0065188585,0.2511637,0.047262408,0.00029940114,0.00026568357,0.000079362,0.04647602],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99975675,0.00004823316,0.000025111582,0.000046533274,0.000085783824,0.000037472102],"domain_scores_gemma":[0.9998178,0.0000697936,0.000026426971,0.000023125844,0.000029145784,0.000033632055],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006307987,0.00059186766,0.0008358844,0.0002348123,0.00031560173,0.0007133207,0.000566075,0.00413802,0.003146718],"category_scores_gemma":[0.00050742127,0.00020976625,0.00047174984,0.00022569268,0.0010745969,0.0017249107,0.0003540156,0.0036104596,0.002534218],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019907607,0.0005584421,0.0030346746,0.00298438,0.0002969332,0.016209142,0.00035699652,0.0005254856,0.09797815,0.04607549,0.35486642,0.4751231],"study_design_scores_gemma":[0.0007388355,0.00082128897,0.0014114861,0.000209585,0.00006784039,0.013092026,0.00020413262,0.00049399934,0.016686883,0.014364223,0.9518669,0.000042825508],"about_ca_topic_score_codex":0.00021908812,"about_ca_topic_score_gemma":0.0006962715,"teacher_disagreement_score":0.00413802,"about_ca_system_score_codex":0.0009434044,"about_ca_system_score_gemma":0.00037298916,"threshold_uncertainty_score":0.010526776},"labels":[],"label_agreement":null},{"id":"W1506730283","doi":"10.1096/fasebj.28.1_supplement.946.13","title":"Acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation (946.13)","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Histone acetyltransferase; Acetylation; Enhancer; Histone; Chromatin; Histone Acetyltransferases; P300-CBP Transcription Factors; Biology; Genetics; Transcription factor; Cell biology; Gene","score_opus":0.00600184555882081,"score_gpt":0.23903982625877046,"score_spread":0.23303798069994966,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1506730283","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98844403,0.0032753341,0.004104342,0.0000838755,0.000021789692,0.000016036156,0.0010819137,0.000046408884,0.0029263075],"genre_scores_gemma":[0.9880437,0.00093045743,0.002106975,0.000044313925,0.0000090413205,0.000019874797,0.0018192158,0.000022865761,0.0070034727],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998857,0.000012258524,0.000007210216,0.00003318851,0.00003216038,0.00002955526],"domain_scores_gemma":[0.9999118,0.000011674815,0.000023059194,0.000010464627,0.000013465441,0.000029635175],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013862054,0.00013568228,0.00012085218,0.00029451287,0.00014796878,0.00026984245,0.00015718666,0.00015699118,0.0019517869],"category_scores_gemma":[0.00015063044,0.00014225487,0.00013671645,0.00024981514,0.00016037507,0.00012640635,0.00022319706,0.0004162256,0.0007002258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013089959,0.000008740427,0.0016168089,0.000017476928,0.000004282881,0.000022839342,0.00001192545,0.000016138689,0.99655473,0.00006287553,0.000023503766,0.0015297956],"study_design_scores_gemma":[0.00001210891,0.000118769276,0.115255,0.000006886433,0.000017940443,0.00022977765,0.000040346134,0.00038352248,0.88106775,0.00006561334,0.0027971459,0.000005089926],"about_ca_topic_score_codex":0.0014274829,"about_ca_topic_score_gemma":0.0034905872,"teacher_disagreement_score":0.0019517869,"about_ca_system_score_codex":0.00036164626,"about_ca_system_score_gemma":0.0001322514,"threshold_uncertainty_score":0.006529391},"labels":[],"label_agreement":null},{"id":"W1512812920","doi":"10.1074/jbc.m115.662155","title":"The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Enzyme; Ubiquitin-Protein Ligases; Prostate cancer; Cell biology; Chemistry; Biology; Cancer; Cancer research; Biochemistry; Genetics; Gene","score_opus":0.029850666707469498,"score_gpt":0.2849213515329971,"score_spread":0.2550706848255276,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1512812920","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9770842,0.010510901,0.006115827,0.0003529157,0.00012621756,0.000036061032,0.0021072656,0.00046346115,0.0032030966],"genre_scores_gemma":[0.9941407,0.0012231932,0.00090076495,0.000069232505,0.000008943894,0.000015958925,0.0012381673,0.000024129984,0.0023789585],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998149,0.000020787444,0.000016185802,0.00005101944,0.000056383877,0.000040699873],"domain_scores_gemma":[0.99991393,0.0000069352645,0.00002715828,0.000012055207,0.000020396381,0.000019479687],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013439119,0.0002706213,0.00029969204,0.00027892092,0.00032750497,0.00047208677,0.00022008868,0.00023218154,0.0017136568],"category_scores_gemma":[0.00012144041,0.00015091452,0.0004186432,0.0004040612,0.00022417941,0.00013551264,0.0002758637,0.0005403908,0.00071373786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001478161,0.00001623528,0.000744022,0.00005935052,0.000017328248,0.000053316457,0.000016616168,0.00014870448,0.9966814,0.000118085976,0.00018936768,0.001807715],"study_design_scores_gemma":[0.000022084338,0.00009711865,0.020085672,0.000008262993,0.000042184263,0.0003493212,0.000057848854,0.0023181567,0.97104317,0.000111119225,0.0058508185,0.00001424396],"about_ca_topic_score_codex":0.002073121,"about_ca_topic_score_gemma":0.002223441,"teacher_disagreement_score":0.002073121,"about_ca_system_score_codex":0.0005943865,"about_ca_system_score_gemma":0.00031765475,"threshold_uncertainty_score":0.0057327747},"labels":[],"label_agreement":null},{"id":"W1531475102","doi":"10.1002/pds.3761","title":"Safety of valproic acid in patients with chronic obstructive pulmonary disease: a population‐based cohort study","year":2015,"lang":"en","type":"article","venue":"Pharmacoepidemiology and Drug Safety","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; Sunnybrook Hospital; University of Toronto; St. Michael's Hospital","funders":"Ontario Ministry of Health and Long-Term Care","keywords":"Medicine; COPD; Valproic Acid; Hazard ratio; Exacerbation; Internal medicine; Phenytoin; Population; Retrospective cohort study; Cohort study; Confidence interval; Epilepsy; Psychiatry","score_opus":0.013774794741572303,"score_gpt":0.30817437839815454,"score_spread":0.29439958365658225,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1531475102","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9988721,0.00021229347,0.000043825865,0.00004032791,0.0000063364373,0.000021077572,0.0006052132,0.00000188214,0.00019697308],"genre_scores_gemma":[0.9989279,0.00016208908,0.000057673187,0.00004059224,0.000015131976,0.000020798176,0.0006526057,0.0000018106399,0.00012133928],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9990693,0.00014515202,0.00010426092,0.00027829866,0.00025740307,0.0001457457],"domain_scores_gemma":[0.99720424,0.00025228842,0.0013644248,0.00033406692,0.00042609946,0.00041888893],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010474395,0.00046148265,0.0006876558,0.00079019764,0.0009315951,0.00094131014,0.00061384274,0.00080195605,0.0013238393],"category_scores_gemma":[0.0029208004,0.00055290724,0.0011674794,0.0016271825,0.00038715507,0.0006041886,0.0005287547,0.00085907005,0.00025050898],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021818472,0.00003393639,0.9990656,0.000007454153,0.00012740846,0.00005258673,0.00004997969,0.000013668314,0.000109922985,0.000005411811,0.000046053858,0.00026974894],"study_design_scores_gemma":[0.000045450262,0.00016946967,0.9992059,0.000006795622,0.00007283206,0.00013216448,0.00008651479,0.00011012016,0.00002172698,0.000008869537,0.00013523675,0.0000051064303],"about_ca_topic_score_codex":0.060105015,"about_ca_topic_score_gemma":0.05897012,"teacher_disagreement_score":0.060105015,"about_ca_system_score_codex":0.0012931573,"about_ca_system_score_gemma":0.0013584069,"threshold_uncertainty_score":0.11951035},"labels":[],"label_agreement":null},{"id":"W1533653418","doi":"10.1007/3-7643-7378-4_2","title":"Abnormalities of chromatin in tumor cells","year":2006,"lang":"en","type":"review","venue":"Birkhäuser-Verlag eBooks","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chromatin; Biology; Cell biology; Cancer research; Genetics; DNA","score_opus":0.025391806238314205,"score_gpt":0.3146619504719654,"score_spread":0.28927014423365116,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1533653418","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00035928198,0.99678636,0.00032611468,0.0002025319,0.00022138363,0.0000055291857,0.000019077755,0.000012873114,0.0020667515],"genre_scores_gemma":[0.0028602623,0.99410915,0.00027947186,0.00019934343,0.00019840404,0.000010696488,0.00005630375,0.0000019287447,0.002284525],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998423,0.00002225628,0.00001606157,0.000045446388,0.000060830982,0.00001305657],"domain_scores_gemma":[0.9998524,0.000058014983,0.000026859301,0.000007859827,0.00003777041,0.00001707045],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033476367,0.00056758017,0.0010378294,0.0017084358,0.0002637473,0.000760184,0.0006735342,0.0010418276,0.0027833923],"category_scores_gemma":[0.00033582412,0.0002487129,0.00022427346,0.0013708175,0.00077853067,0.0008680976,0.000429771,0.0008473796,0.002764259],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007903475,0.000027440568,0.00040964992,0.0065638255,0.000042051444,0.0005999484,0.000108868735,0.00035061676,0.014320225,0.004703441,0.01751156,0.9552834],"study_design_scores_gemma":[0.00001416522,0.00009025287,0.0020955303,0.00091567246,0.000045415763,0.0049019586,0.000079472535,0.000072848154,0.005339853,0.0022406885,0.98418355,0.000020527554],"about_ca_topic_score_codex":0.0008841838,"about_ca_topic_score_gemma":0.0013631767,"teacher_disagreement_score":0.0027833923,"about_ca_system_score_codex":0.00077277713,"about_ca_system_score_gemma":0.00047854264,"threshold_uncertainty_score":0.009311378},"labels":[],"label_agreement":null},{"id":"W1555940842","doi":"10.1023/a:1022935117193","title":"Angiogenesis and the role of epigenetics in metastasis","year":2003,"lang":"en","type":"review","venue":"Clinical & Experimental Metastasis","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University Medical Centre; University of Guelph","funders":"National Cancer Institute","keywords":"Epigenetics; Biology; Angiogenesis; Metastasis; Cancer; Cancer research; Tumor microenvironment; Tumor progression; Genetic heterogeneity; Stromal cell; Oncogene; Genetics; Gene; Phenotype; Cell cycle","score_opus":0.06297406975367671,"score_gpt":0.43610296411813776,"score_spread":0.37312889436446106,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1555940842","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009113498,0.9979693,0.00024227962,0.00047483458,0.00036235683,0.000003173657,0.0000069659336,0.0000063456405,0.0008434932],"genre_scores_gemma":[0.0010105113,0.99690396,0.00023240772,0.0003080397,0.00056134857,0.0000070787496,0.00001382136,0.0000012382387,0.00096163084],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998161,0.0000360272,0.000018825478,0.000032752934,0.00007577405,0.000020447005],"domain_scores_gemma":[0.9996679,0.00017628405,0.000029957928,0.00001247392,0.00008000308,0.00003346849],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009772787,0.001017248,0.0017710902,0.0015465276,0.00040623004,0.0011754233,0.0012844232,0.0018141114,0.0027944962],"category_scores_gemma":[0.0006306686,0.00036516698,0.00038824,0.0018923349,0.0012698319,0.0014885957,0.00063811283,0.0022699353,0.00165273],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001880842,0.00008928092,0.0003231773,0.0054775733,0.00008698049,0.0004968604,0.00005816356,0.0005605441,0.0051876106,0.008182417,0.048003744,0.93134564],"study_design_scores_gemma":[0.00006259733,0.000116563075,0.0010633331,0.001082967,0.00009838725,0.0019751622,0.00009090408,0.00021350902,0.0014792626,0.006070522,0.9877216,0.000025265237],"about_ca_topic_score_codex":0.0016666966,"about_ca_topic_score_gemma":0.0043043615,"teacher_disagreement_score":0.0027944962,"about_ca_system_score_codex":0.0011628285,"about_ca_system_score_gemma":0.0010583366,"threshold_uncertainty_score":0.009348571},"labels":[],"label_agreement":null},{"id":"W1575380345","doi":"10.18433/j3xp4r","title":"Modulation of Butyrate Anticancer Activity by Solid Lipid Nanoparticle Delivery: An in Vitro Investigation on Human Breast Cancer and Leukemia Cell Lines","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Regione Piemonte","keywords":"Butyrate; Sodium butyrate; Chemistry; Cancer cell; Cell cycle; Apoptosis; Cancer research; Histone deacetylase inhibitor; Acute promyelocytic leukemia; Histone deacetylase; Biochemistry; Cancer; Biology; Retinoic acid; Histone","score_opus":0.05844678749484314,"score_gpt":0.40249414407388595,"score_spread":0.34404735657904284,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1575380345","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9808203,0.011318752,0.0049104183,0.00017597944,0.000065569155,0.00012567153,0.00060216687,0.00005089466,0.0019303078],"genre_scores_gemma":[0.9803916,0.008717026,0.0063989144,0.000082117345,0.000018319748,0.00012916655,0.00090494985,0.000023566177,0.003334272],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997557,0.00006989729,0.00002670772,0.000043181073,0.000071469134,0.000033038057],"domain_scores_gemma":[0.9998957,0.000030739135,0.000017226586,0.000014135895,0.000032324628,0.000009810295],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003283895,0.00034327348,0.00048593176,0.00019320691,0.00017907338,0.00020261975,0.00015024559,0.0002989005,0.00078601786],"category_scores_gemma":[0.00012759847,0.0001538884,0.0003551385,0.00032902876,0.00015294076,0.00013350566,0.00013706431,0.00030671555,0.00029607958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020009701,0.00013539603,0.00020175199,0.00014705176,0.000009966054,0.00005023173,0.00003613428,0.00020976707,0.9967354,0.00003074651,0.000050272993,0.0021931415],"study_design_scores_gemma":[0.000022066939,0.0011860118,0.001216493,0.000008938862,0.000036205638,0.00010520341,0.000027055008,0.0007167432,0.9949942,0.000012591674,0.001670408,0.0000041470144],"about_ca_topic_score_codex":0.0019406833,"about_ca_topic_score_gemma":0.0029950135,"teacher_disagreement_score":0.0019406833,"about_ca_system_score_codex":0.00029241477,"about_ca_system_score_gemma":0.00018615244,"threshold_uncertainty_score":0.003858745},"labels":[],"label_agreement":null},{"id":"W1581326054","doi":"10.1074/jbc.m200349200","title":"The Histone Deacetylase Inhibitor Trichostatin A Blocks Progesterone Receptor-mediated Transactivation of the Mouse Mammary Tumor Virus Promoter in Vivo","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"Trichostatin A; Transactivation; In vivo; Mouse mammary tumor virus; Progesterone receptor; Histone deacetylase inhibitor; Histone deacetylase; Cancer research; HDAC11; Mammary tumor; Biology; Chemistry; Virus; Histone; Virology; Estrogen receptor; Gene; Transcription factor; Cancer; Breast cancer; Genetics","score_opus":0.015364128653564782,"score_gpt":0.2505284118106969,"score_spread":0.23516428315713211,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1581326054","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993067,0.0022827734,0.0020866378,0.00012298458,0.000067294946,0.000028793098,0.00035970047,0.00011116052,0.0018736001],"genre_scores_gemma":[0.9920699,0.002303447,0.001539388,0.00004898584,0.000027375037,0.00003980212,0.00082067924,0.0000376521,0.0031127855],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978024,0.000053314176,0.00002095597,0.000023719562,0.000058084865,0.00006376285],"domain_scores_gemma":[0.99980646,0.000064628046,0.00004632199,0.000029036812,0.000012293505,0.000041312236],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020025639,0.0003850941,0.00030441617,0.00027862538,0.000110784924,0.00024654693,0.00030389073,0.00017346937,0.00103483],"category_scores_gemma":[0.00020056289,0.00019241656,0.00026564256,0.0002020433,0.0002914706,0.00010642572,0.00012738402,0.00053792767,0.00037917917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001263735,0.000025116136,0.000057431847,0.00001316685,0.0000040188843,0.000014565246,0.0000053887916,0.000025646068,0.9992079,0.00003813899,0.000017486032,0.00046472816],"study_design_scores_gemma":[0.000024335968,0.0005082287,0.0012628193,0.0000023727864,0.000012773524,0.000073909825,0.000009489544,0.00039634225,0.9965965,0.000017714672,0.0010937346,0.0000016527054],"about_ca_topic_score_codex":0.001662978,"about_ca_topic_score_gemma":0.0024394745,"teacher_disagreement_score":0.001662978,"about_ca_system_score_codex":0.0003910329,"about_ca_system_score_gemma":0.00039375815,"threshold_uncertainty_score":0.0034618378},"labels":[],"label_agreement":null},{"id":"W1585396644","doi":"10.1046/j.1471-4159.2003.02223.x","title":"Cell type‐dependent recruitment of trichostatin A‐sensitive repression of the human 5‐HT1A receptor gene","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Psychological repression; Repressor; Trichostatin A; Biology; Histone deacetylase; Gene silencing; Regulation of gene expression; Molecular biology; Gene; Gene expression; Genetics; Histone","score_opus":0.026539169168005156,"score_gpt":0.3085797071166431,"score_spread":0.282040537948638,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1585396644","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9945127,0.001421311,0.0010893804,0.000052102936,0.000033514913,0.000020798772,0.0007135244,0.00006304288,0.0020936897],"genre_scores_gemma":[0.99305564,0.0007354851,0.0007373718,0.00004607605,0.000012404867,0.000025755993,0.0016984737,0.000016315193,0.0036725241],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989057,0.000012900183,0.000009461225,0.000025377907,0.000024874811,0.000036832],"domain_scores_gemma":[0.9999416,0.00001603554,0.000010587105,0.000011405665,0.0000059483614,0.0000143560255],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007193993,0.0001765708,0.00019488354,0.00013470859,0.0000892366,0.0002105343,0.00012158257,0.000118651325,0.001892233],"category_scores_gemma":[0.000079949124,0.000111464484,0.0002868538,0.00012050786,0.0001385773,0.00006986877,0.00014877378,0.00033334264,0.00059115054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00004471376,0.000011095501,0.00012683605,0.000010707381,0.000003049215,0.000028818347,0.000007647945,0.000009195302,0.9992193,0.00003454065,0.00003784666,0.0004661723],"study_design_scores_gemma":[0.000012816466,0.00018669905,0.014211837,0.0000027648987,0.000012013621,0.00032688738,0.000022820448,0.0005145157,0.9818273,0.000018290619,0.0028597445,0.0000041751236],"about_ca_topic_score_codex":0.0012553511,"about_ca_topic_score_gemma":0.0022686676,"teacher_disagreement_score":0.001892233,"about_ca_system_score_codex":0.00026860318,"about_ca_system_score_gemma":0.00016009394,"threshold_uncertainty_score":0.006330192},"labels":[],"label_agreement":null},{"id":"W1633240662","doi":"10.25011/cim.v35i6.19205","title":"Vascular endothelial growth factor production is induced by histone deacetylase 1 and suppressed by von Hippel-Lindau protein in HaCaT cells","year":2012,"lang":"en","type":"article","venue":"Clinical and investigative medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"HaCaT; Histone deacetylase; Chemistry; Cancer research; Cell biology; Histone; Medicine; Biology; Biochemistry; Gene; In vitro","score_opus":0.06758136686946642,"score_gpt":0.3356961276658737,"score_spread":0.2681147607964073,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1633240662","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98958963,0.002879621,0.003394565,0.00024378735,0.00010567612,0.00003632866,0.0010152664,0.00019296775,0.0025421449],"genre_scores_gemma":[0.9908502,0.0012033927,0.00211846,0.00008353013,0.000022562312,0.00006814456,0.0016181562,0.000023753699,0.004011894],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973947,0.00002505092,0.000026464797,0.00005300777,0.000092600276,0.0000634008],"domain_scores_gemma":[0.99989367,0.000016071774,0.000029220137,0.000018667086,0.000019208006,0.000023216215],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016052238,0.0002964598,0.00029974233,0.00024494802,0.0003234599,0.00030627812,0.00022696197,0.0002332608,0.001216395],"category_scores_gemma":[0.00009743692,0.0002018317,0.0003280725,0.00035883617,0.00030991124,0.00022215673,0.00015534338,0.0005020239,0.0005394426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007440734,0.000041401596,0.00024578822,0.00004593433,0.000006895267,0.00004770847,0.000032202355,0.000044755132,0.9986112,0.00013774393,0.00010238828,0.0006095428],"study_design_scores_gemma":[0.000035446235,0.00019128915,0.0062228683,0.0000061228175,0.000024289251,0.0002018985,0.00007101512,0.0021570555,0.98584783,0.00007514761,0.005158585,0.000008338236],"about_ca_topic_score_codex":0.0030479147,"about_ca_topic_score_gemma":0.0024452505,"teacher_disagreement_score":0.0030479147,"about_ca_system_score_codex":0.00064038904,"about_ca_system_score_gemma":0.00035321913,"threshold_uncertainty_score":0.006060362},"labels":[],"label_agreement":null},{"id":"W1658964703","doi":"10.1080/15592294.2015.1039222","title":"Barcelona conference on epigenetics and cancer: 50 years of histone acetylation","year":2015,"lang":"en","type":"article","venue":"Epigenetics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Biology; Histone; Acetylation; Chromatin; Genetics; Library science; Gene","score_opus":0.042754842667278095,"score_gpt":0.354131746579798,"score_spread":0.31137690391251993,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1658964703","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0013231484,0.7897902,0.001774264,0.09161924,0.088038914,0.000031784148,0.00027781396,0.00017200956,0.026972607],"genre_scores_gemma":[0.0429719,0.66539866,0.0050270525,0.05167874,0.07471475,0.00019398257,0.0014860294,0.0003700745,0.1581588],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9973673,0.0007631976,0.00013591384,0.0003826817,0.00085084396,0.00050013623],"domain_scores_gemma":[0.99604636,0.00074896245,0.00021106095,0.00025350874,0.00099711,0.0017428196],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007105472,0.001207418,0.0012815887,0.0027598552,0.0015677789,0.006265495,0.001468047,0.0033486343,0.014428989],"category_scores_gemma":[0.004534758,0.00053152005,0.0009218169,0.0027720977,0.0024571456,0.002622476,0.0040359898,0.006001428,0.005269086],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027594983,0.000058721067,0.0004250938,0.0005820709,0.0000349094,0.00008494274,0.00042639714,0.00028847813,0.0008134654,0.013687561,0.7824189,0.20090345],"study_design_scores_gemma":[0.000008140644,0.000028790491,0.0006837491,0.00028899274,0.00000795724,0.00006008425,0.000099095814,0.000027001735,0.00014480243,0.0016522476,0.9969891,0.000010060525],"about_ca_topic_score_codex":0.0061156093,"about_ca_topic_score_gemma":0.011087145,"teacher_disagreement_score":0.014428989,"about_ca_system_score_codex":0.007935674,"about_ca_system_score_gemma":0.0047253813,"threshold_uncertainty_score":0.05757761},"labels":[],"label_agreement":null},{"id":"W1683373684","doi":"10.1186/s13104-015-1336-0","title":"Insulin and IGF-1, but not 17β-estradiol, alter the subcellular localization of MIER1α in MCF7 breast carcinoma cells","year":2015,"lang":"en","type":"article","venue":"BMC Research Notes","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Nuclear localization sequence; Subcellular localization; Breast carcinoma; Cytoplasm; Cancer research; Estrogen receptor; Cell nucleus; Breast cancer; Nucleus; Nuclear transport; Insulin; Estrogen; Regulator; Biology; Carcinoma; Internal medicine; Endocrinology; Cell biology; Medicine; Cancer; Biochemistry; Gene","score_opus":0.08543200518900988,"score_gpt":0.3413543859476195,"score_spread":0.2559223807586096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1683373684","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98718566,0.0050682425,0.001555272,0.00029791804,0.00009587932,0.000024586045,0.001276196,0.00009354234,0.0044027623],"genre_scores_gemma":[0.98443836,0.0036115542,0.0028930507,0.00017075456,0.000018074026,0.000051587584,0.0026346378,0.000036255402,0.0061457753],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984753,0.000016912343,0.000015743979,0.000023777828,0.000058236044,0.000037725044],"domain_scores_gemma":[0.9999163,0.00002093509,0.000017446839,0.000011032016,0.000015296906,0.000018998602],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014876753,0.0003197494,0.00023608968,0.00028975942,0.00017162177,0.00023244601,0.00017606057,0.00020132487,0.0016135498],"category_scores_gemma":[0.000080617625,0.00013394418,0.00031244033,0.00021441701,0.00014835926,0.00010466608,0.000100428304,0.0004198458,0.0006688276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000117565134,0.000024454996,0.00037373882,0.00003281484,0.0000080068885,0.00004592581,0.000022714055,0.000020215057,0.99846506,0.00004007585,0.00007091325,0.0007785086],"study_design_scores_gemma":[0.000008994026,0.00019518401,0.009512147,0.000006047513,0.000021643185,0.00021643816,0.00006428283,0.00026858517,0.9871421,0.000013982209,0.002546658,0.0000040341024],"about_ca_topic_score_codex":0.0025196439,"about_ca_topic_score_gemma":0.0029304551,"teacher_disagreement_score":0.0025196439,"about_ca_system_score_codex":0.00037414,"about_ca_system_score_gemma":0.00016868926,"threshold_uncertainty_score":0.005397916},"labels":[],"label_agreement":null},{"id":"W1773725721","doi":"10.1016/j.febslet.2015.08.009","title":"Loss of histone deacetylase Hdac1 disrupts metabolic processes in intestinal epithelial cells","year":2015,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"HDAC1; Histone deacetylase; Cell biology; Chemistry; Histone; Histone deacetylase 5; HDAC11; Histone deacetylase 2; HDAC10; HDAC4; Biochemistry; Biology; Gene","score_opus":0.017372061209646007,"score_gpt":0.3045115873385098,"score_spread":0.2871395261288638,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1773725721","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98926485,0.0022524097,0.0032543621,0.00033858814,0.00012929739,0.000029412657,0.0016410846,0.0002536878,0.002836377],"genre_scores_gemma":[0.9921017,0.001340009,0.0015632364,0.00010397115,0.000015281872,0.000028238808,0.0010516143,0.000058098365,0.0037378836],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981433,0.000024235269,0.000029742649,0.0000350557,0.000043378972,0.000053189335],"domain_scores_gemma":[0.9998011,0.000035050885,0.000052520158,0.0000366973,0.000012573501,0.00006203821],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015471483,0.00037862544,0.00035918682,0.0002661445,0.00020026478,0.00044571247,0.00029279862,0.000314713,0.0019068879],"category_scores_gemma":[0.000118159965,0.00022406488,0.0003608896,0.00026575656,0.00027554802,0.00020627944,0.00020578322,0.0007008404,0.0006926463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019832609,0.000040626655,0.00017038196,0.000028190094,0.000008531302,0.000040971187,0.00000949845,0.00006277251,0.99832076,0.00009608266,0.00006399154,0.000959902],"study_design_scores_gemma":[0.000017423163,0.00015963383,0.003182156,0.000004075642,0.000015382062,0.00010105466,0.000035462126,0.000477102,0.9940177,0.000034777488,0.0019522893,0.0000029538878],"about_ca_topic_score_codex":0.0017568351,"about_ca_topic_score_gemma":0.0018889668,"teacher_disagreement_score":0.0019068879,"about_ca_system_score_codex":0.0004948053,"about_ca_system_score_gemma":0.00031991556,"threshold_uncertainty_score":0.0063792467},"labels":[],"label_agreement":null},{"id":"W1827335300","doi":"10.18433/j3ts4v","title":"Iron Complexation to Histone Deacetylase Inhibitors SAHA and LAQ824 in PEGylated Liposomes Can Considerably Improve Pharmacokinetics in Rats","year":2015,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; University of Wisconsin Carbone Cancer Center; University of Wisconsin-Madison","keywords":"Chemistry; In vivo; Pharmacokinetics; Liposome; Solubility; Pharmacology; In vitro; Bioavailability; Chromatography; Combinatorial chemistry; Biochemistry; Organic chemistry; Medicine","score_opus":0.06701595310970096,"score_gpt":0.41597434121105603,"score_spread":0.34895838810135504,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1827335300","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9858067,0.0014352739,0.01084727,0.00019536978,0.000048591282,0.00006783288,0.00020618166,0.00026016397,0.001132578],"genre_scores_gemma":[0.9904171,0.0007353394,0.0047509177,0.000055893008,0.000013324599,0.000046773457,0.00022036735,0.000043057025,0.0037171908],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991083,0.000016338323,0.0000071150807,0.000025270996,0.000019735144,0.000020629068],"domain_scores_gemma":[0.99991643,0.000010563693,0.000036872247,0.0000101356045,0.000013328414,0.000012719274],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865444,0.00032313107,0.00023398272,0.00020495451,0.00009411825,0.00012982554,0.00020217839,0.00026980872,0.0009335535],"category_scores_gemma":[0.00018953625,0.00014854017,0.0002262626,0.000077852324,0.00022362737,0.00029555502,0.00012811222,0.00041444827,0.00026216634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00049772207,0.000063909625,0.00015461582,0.000028641554,0.000006113902,0.00002679481,0.000013471556,0.000120374956,0.9957457,0.000062187966,0.000054994907,0.0032254695],"study_design_scores_gemma":[0.000022871032,0.0006534566,0.00043077042,0.0000020172308,0.000009221259,0.000040427505,0.0000041180833,0.00057939807,0.9973647,0.000019919535,0.0008710395,0.0000020680222],"about_ca_topic_score_codex":0.00082536176,"about_ca_topic_score_gemma":0.00066360564,"teacher_disagreement_score":0.0009335535,"about_ca_system_score_codex":0.00028550677,"about_ca_system_score_gemma":0.00019495789,"threshold_uncertainty_score":0.003123045},"labels":[],"label_agreement":null},{"id":"W1843609228","doi":"10.1593/neo.08474","title":"Expression of Class I Histone Deacetylases Indicates Poor Prognosis in Endometrioid Subtypes of Ovarian and Endometrial Carcinomas","year":2008,"lang":"en","type":"article","venue":"Neoplasia","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency; Vancouver General Hospital","funders":"Eli Lilly Canada; BC Cancer Agency; Eli Lilly and Company","keywords":"Serous fluid; Immunohistochemistry; Hazard ratio; Oncology; Ovarian cancer; Endometrial cancer; Cancer research; Ovarian carcinoma; Carcinoma; Internal medicine; Medicine; Biology; Cancer; Confidence interval","score_opus":0.01605565351606166,"score_gpt":0.26825181453898844,"score_spread":0.2521961610229268,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1843609228","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99921465,0.0003981264,0.000094734096,0.000018684888,0.0000031864358,0.0000026482796,0.00008714954,0.0000023447046,0.00017841418],"genre_scores_gemma":[0.99965835,0.00011311418,0.00006504099,0.000008612108,0.000005875087,0.0000024204985,0.00009105846,9.77524e-7,0.000054532968],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99975497,0.00006743487,0.000030426543,0.000056844485,0.000045690507,0.000044728604],"domain_scores_gemma":[0.998565,0.00034968884,0.0006842896,0.00011779015,0.000099629426,0.00018367924],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00056585006,0.00017536727,0.0003157125,0.0004789499,0.0002725085,0.00037020905,0.00022968839,0.0003022173,0.0009924873],"category_scores_gemma":[0.001965345,0.00018012775,0.0002460146,0.00049317797,0.00038238193,0.00025846536,0.0003197796,0.00038940928,0.00020439968],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016515212,0.000005298599,0.9981833,0.000004746318,0.000017712531,0.000034347708,0.000014384621,0.000018433195,0.00075937185,0.0000051394877,0.000023300432,0.0007688413],"study_design_scores_gemma":[0.000006814832,0.000047701884,0.998781,0.0000033316512,0.000019692157,0.00045768116,0.00008358762,0.00016775155,0.0002947466,0.00003142701,0.000103886094,0.000002269124],"about_ca_topic_score_codex":0.0012078385,"about_ca_topic_score_gemma":0.00167424,"teacher_disagreement_score":0.0012078385,"about_ca_system_score_codex":0.00016315468,"about_ca_system_score_gemma":0.00019594001,"threshold_uncertainty_score":0.0033201575},"labels":[],"label_agreement":null},{"id":"W1870993152","doi":"10.1002/bdrb.21108","title":"Effects of Ethylene Glycol Monomethyl Ether and Its Metabolite, 2‐Methoxyacetic Acid, on Organogenesis Stage Mouse Limbs In Vitro","year":2014,"lang":"en","type":"article","venue":"Birth Defects Research Part B Developmental and Reproductive Toxicology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Acetylation; Metabolite; Apoptosis; Chemistry; In vitro; Biochemistry; Cell biology; Biology","score_opus":0.026081011170169366,"score_gpt":0.309449145806608,"score_spread":0.2833681346364386,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1870993152","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99333405,0.0024776233,0.0013533499,0.00006584868,0.0000338206,0.00003840194,0.00066920265,0.000049292288,0.0019783054],"genre_scores_gemma":[0.99155504,0.002133854,0.0016068214,0.00008677692,0.000013688083,0.000055358178,0.0008526133,0.000018180412,0.003677637],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984264,0.000052475276,0.000016557522,0.000024698556,0.00002526995,0.000038320766],"domain_scores_gemma":[0.9997739,0.00006818488,0.00005820294,0.000022973663,0.000024708026,0.000052040297],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021976324,0.00047487373,0.00022237076,0.00030970035,0.00014226843,0.0002087475,0.0001862833,0.00024570542,0.001065772],"category_scores_gemma":[0.000115466035,0.00022047662,0.00037517544,0.00013572277,0.0001682865,0.00013327684,0.00013038306,0.0004978627,0.0003109601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017072208,0.000025646206,0.00021458771,0.000019068879,0.0000049709047,0.000042924457,0.000013055675,0.00004428242,0.9990446,0.0000128895135,0.0000135908695,0.0003936093],"study_design_scores_gemma":[0.0000064664227,0.00067204586,0.003422699,0.0000039572124,0.000013164281,0.00004787906,0.000015643976,0.00015172419,0.9951874,0.000010041281,0.00046669072,0.0000022565437],"about_ca_topic_score_codex":0.0012714844,"about_ca_topic_score_gemma":0.0028764259,"teacher_disagreement_score":0.0012714844,"about_ca_system_score_codex":0.00023661563,"about_ca_system_score_gemma":0.00022873381,"threshold_uncertainty_score":0.0035653114},"labels":[],"label_agreement":null},{"id":"W187324382","doi":"10.1023/a:1026532032454","title":"Reaching for New Heitz","year":2000,"lang":"en","type":"article","venue":"Genetica","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Biology; Human genetics; Evolutionary biology; Computational biology; Genetics; Gene","score_opus":0.015539475326326858,"score_gpt":0.29047285426000874,"score_spread":0.27493337893368186,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W187324382","genre_codex":"other","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.01877344,0.013344276,0.04826376,0.15754542,0.010543509,0.000105193634,0.00030930134,0.0018393282,0.74927574],"genre_scores_gemma":[0.17661631,0.0069924,0.018542457,0.03814075,0.0023566547,0.00008973933,0.00030978245,0.0008706818,0.75608116],"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.998607,0.00023825078,0.00003871223,0.0003032804,0.00046857842,0.00034422753],"domain_scores_gemma":[0.9969344,0.00039062943,0.000121006735,0.00085624703,0.00064368814,0.001054056],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0026803622,0.0009115339,0.00061904255,0.0012900009,0.0036580316,0.006928116,0.0011012774,0.0026003243,0.09185747],"category_scores_gemma":[0.004382957,0.00038983568,0.0005645878,0.00055350544,0.0062406585,0.010780432,0.005664889,0.0072017335,0.03257113],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001530939,0.00011649479,0.00062709075,0.00012016752,0.000029688992,0.00019700322,0.0012372987,0.00025658877,0.008540761,0.7406401,0.13082108,0.117260754],"study_design_scores_gemma":[0.000011471567,0.000040944287,0.00028732384,0.000071055336,0.000009050349,0.00014712606,0.00081244344,0.0001894518,0.0019905113,0.17985661,0.81656396,0.000020127967],"about_ca_topic_score_codex":0.0017182203,"about_ca_topic_score_gemma":0.003668671,"teacher_disagreement_score":0.09185747,"about_ca_system_score_codex":0.0027658946,"about_ca_system_score_gemma":0.0036034933,"threshold_uncertainty_score":0.30729383},"labels":[],"label_agreement":null},{"id":"W1879765960","doi":"10.1002/bdrb.21149","title":"Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs","year":2015,"lang":"en","type":"article","venue":"Birth Defects Research Part B Developmental and Reproductive Toxicology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Apoptosis; Biology; Histone deacetylase; Survivin; Poly ADP ribose polymerase; PARP1; Molecular biology; Cancer research; Caspase 3; DNA damage; Histone deacetylase inhibitor; Programmed cell death; Cell biology; Histone; Gene; Polymerase; Biochemistry; DNA","score_opus":0.040760842988777565,"score_gpt":0.2919301816735382,"score_spread":0.2511693386847606,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1879765960","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99433017,0.0026469282,0.0013291464,0.00006820205,0.000021575996,0.000018189266,0.00046030743,0.000062749656,0.001062679],"genre_scores_gemma":[0.99384296,0.0014577988,0.0009934882,0.00005082233,0.000007792904,0.000034004497,0.0005636606,0.00001649821,0.0030329216],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998628,0.00002398023,0.00001405558,0.00003375922,0.000030483327,0.000034871035],"domain_scores_gemma":[0.99986506,0.000016280555,0.000051942054,0.0000133213125,0.000010683201,0.0000425794],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009124168,0.00033091533,0.00020375232,0.0003816472,0.000112696966,0.00021076266,0.0001150677,0.00019721228,0.0008687513],"category_scores_gemma":[0.00008043725,0.00021535395,0.00021419572,0.00011499433,0.00020942932,0.00012535688,0.00014583825,0.000530619,0.00018742283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013676377,0.000013059671,0.00019823284,0.000015889123,0.0000034993664,0.00006118088,0.000009301941,0.000028424902,0.99901783,0.00002926021,0.000014919847,0.0004716472],"study_design_scores_gemma":[0.000011375119,0.0005086909,0.008872692,0.000006411491,0.000013284247,0.00024795023,0.000024210472,0.00026978445,0.9889397,0.00003822338,0.0010653461,0.000002375428],"about_ca_topic_score_codex":0.0005184072,"about_ca_topic_score_gemma":0.0010015044,"teacher_disagreement_score":0.0008687513,"about_ca_system_score_codex":0.00027695525,"about_ca_system_score_gemma":0.00016094187,"threshold_uncertainty_score":0.0029062033},"labels":[],"label_agreement":null},{"id":"W1929921628","doi":"10.1111/j.1365-2141.2010.08342.x","title":"The class‐I HDAC inhibitor MGCD0103 induces apoptosis in Hodgkin lymphoma cell lines and synergizes with proteasome inhibitors by an HDAC6‐independent mechanism","year":2010,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"National Cancer Institute","keywords":"Proteasome; Cancer research; Proteasome inhibitor; Histone deacetylase; Carfilzomib; HDAC6; Apoptosis; In vivo; Bortezomib; Lymphoma; Biology; Cell culture; Chemistry; Multiple myeloma; Cell biology; Immunology; Histone; Biochemistry; Gene","score_opus":0.004500906008880796,"score_gpt":0.2286580455090533,"score_spread":0.22415713950017252,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1929921628","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99329454,0.0033750965,0.0009004197,0.00009022451,0.000044237444,0.00005156658,0.00027308808,0.00012042015,0.0018502728],"genre_scores_gemma":[0.99580705,0.001601654,0.0007274072,0.000074464435,0.00001644907,0.00003769196,0.0004899449,0.000011231057,0.0012340393],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999879,0.000023483331,0.000013211756,0.000013761892,0.00003500124,0.000035419667],"domain_scores_gemma":[0.99994206,0.000011795163,0.000014133018,0.000009359278,0.0000061175865,0.00001648876],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015905182,0.00031287104,0.0004325284,0.00024224394,0.00013618157,0.0002522358,0.00017654218,0.00018085401,0.00091292855],"category_scores_gemma":[0.00008665577,0.00013816419,0.00028856297,0.00025102828,0.00015991268,0.0001163762,0.00015440799,0.0004318243,0.00027403765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089402066,0.00029594635,0.0010768066,0.000107026746,0.0000375557,0.00007081562,0.000028933966,0.00022934482,0.98527086,0.00010212008,0.0003501476,0.0115364175],"study_design_scores_gemma":[0.00029169075,0.003650975,0.014804079,0.000009455532,0.00006630973,0.00050308864,0.000040697396,0.00106962,0.9745368,0.0000679735,0.004952051,0.0000072479825],"about_ca_topic_score_codex":0.00087424397,"about_ca_topic_score_gemma":0.0029488367,"teacher_disagreement_score":0.00091292855,"about_ca_system_score_codex":0.0003440567,"about_ca_system_score_gemma":0.00027937445,"threshold_uncertainty_score":0.0030540824},"labels":[],"label_agreement":null},{"id":"W1933321168","doi":"10.1093/genetics/154.2.657","title":"Mutational Analysis of a Histone Deacetylase in Drosophila melanogaster: Missense Mutations Suppress Gene Silencing Associated With Position Effect Variegation","year":2000,"lang":"en","type":"article","venue":"Genetics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Histone deacetylase; Genetics; HDAC11; Histone deacetylase 5; Missense mutation; Histone deacetylase 2; Gene silencing; HDAC10; Histone deacetylase inhibitor; Drosophila melanogaster; Histone; SAP30; Gene; Phenotype","score_opus":0.006100146646407296,"score_gpt":0.28133896060523395,"score_spread":0.27523881395882666,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1933321168","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9940315,0.0007347836,0.0027093533,0.000073050884,0.000025331035,0.00004974754,0.0006427289,0.00015194781,0.001581582],"genre_scores_gemma":[0.99577516,0.00051521003,0.002015861,0.000046570418,0.0000066222897,0.000018115843,0.0003863109,0.000037581925,0.001198565],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992645,0.000010337882,0.000012687504,0.000017636723,0.000022445738,0.000010527051],"domain_scores_gemma":[0.9998292,0.00004898282,0.00005029331,0.000015580363,0.000013073593,0.000042776654],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008738834,0.00061315624,0.00018337987,0.0004198832,0.00024403264,0.00020461691,0.00024534398,0.00040721506,0.0011760903],"category_scores_gemma":[0.00016267963,0.00017308044,0.00034415248,0.0001936861,0.0002873087,0.00009518264,0.00021154361,0.00038623827,0.0004380533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000047016503,0.000011628792,0.00068149844,0.00003533487,0.000013913687,0.00036057833,0.000024537028,0.00015925133,0.9969708,0.00013366016,0.000037990685,0.0015237336],"study_design_scores_gemma":[0.00003339552,0.0002368182,0.02682688,0.000017472981,0.0000722141,0.0024254934,0.000074446056,0.001830539,0.96582127,0.00009190187,0.0025535226,0.000016044036],"about_ca_topic_score_codex":0.0015359253,"about_ca_topic_score_gemma":0.0031516592,"teacher_disagreement_score":0.0015359253,"about_ca_system_score_codex":0.00047728393,"about_ca_system_score_gemma":0.00018857923,"threshold_uncertainty_score":0.0039343834},"labels":[],"label_agreement":null},{"id":"W1944864148","doi":"10.1002/mds.26180","title":"Graft‐induced dyskinesias fail to respond to 5HT<sub>1A</sub> agonist in the long‐term","year":2015,"lang":"en","type":"letter","venue":"Movement Disorders","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Western Hospital; University of Toronto; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Term (time); Agonist; Information retrieval; Computer science; Content (measure theory); World Wide Web; Web site; Psychology; The Internet; Medicine; Receptor; Internal medicine; Mathematics","score_opus":0.019248699562666245,"score_gpt":0.28771711932848,"score_spread":0.26846841976581376,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1944864148","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.909037,0.0045682075,0.004381718,0.036496297,0.0049628555,0.00014078015,0.0006924566,0.00056337705,0.03915731],"genre_scores_gemma":[0.9568332,0.0014188064,0.0007758231,0.011264087,0.0008281588,0.00007637375,0.0003714675,0.000053159365,0.028378969],"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985707,0.000021408832,0.000014822733,0.00001840435,0.00004468567,0.000043607502],"domain_scores_gemma":[0.999627,0.0001721323,0.0000560193,0.000054500688,0.000024345849,0.00006597848],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018255519,0.0002991625,0.00061294617,0.00012266089,0.00031285585,0.0003850018,0.00026320494,0.002031107,0.003252542],"category_scores_gemma":[0.0007356735,0.00009390301,0.00036620235,0.00011488493,0.00054550305,0.00030556673,0.0001899576,0.0018221871,0.0016706468],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.006682918,0.0022993595,0.016911983,0.00038174127,0.00022096219,0.38901836,0.0004518763,0.0008986312,0.30376172,0.014285624,0.08743804,0.17764872],"study_design_scores_gemma":[0.001468905,0.008553626,0.098426305,0.00022950908,0.00023328903,0.5397175,0.0005878734,0.008118546,0.12653413,0.016623996,0.19933356,0.00017269951],"about_ca_topic_score_codex":0.0003197128,"about_ca_topic_score_gemma":0.00068669254,"teacher_disagreement_score":0.003252542,"about_ca_system_score_codex":0.00042634908,"about_ca_system_score_gemma":0.0002346185,"threshold_uncertainty_score":0.010880828},"labels":[],"label_agreement":null},{"id":"W1952281848","doi":"10.1016/j.ijrobp.2015.04.038","title":"A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma","year":2015,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":203,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Regional Municipality of Durham; Lakeridge Health","funders":"National Institutes of Health","keywords":"Medicine; Temozolomide; Toxicity; Valproic Acid; Radiation therapy; Internal medicine; Adverse effect; Histone deacetylase inhibitor; Oncology; Pharmacology; Histone deacetylase; Epilepsy","score_opus":0.01847940863686564,"score_gpt":0.34903845313299364,"score_spread":0.330559044496128,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1952281848","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9957632,0.0010473139,0.000258117,0.0002931638,0.0001322096,0.0013866082,0.0003933248,0.000029060826,0.00069696154],"genre_scores_gemma":[0.99135697,0.0018869281,0.0011786651,0.00051755976,0.00022414002,0.002040896,0.0011720975,0.000030919393,0.0015917867],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9993705,0.0002676995,0.0000327173,0.00013805073,0.00005160026,0.00013941679],"domain_scores_gemma":[0.99900323,0.00014306483,0.00014484112,0.00010005552,0.000061266925,0.00054759305],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016844263,0.0020426558,0.0036951222,0.0007451132,0.00065365236,0.0012700254,0.0012988193,0.0014541355,0.003340182],"category_scores_gemma":[0.0013274446,0.0011664734,0.0021183738,0.0008837559,0.0015811799,0.0014478562,0.0005433907,0.0036316966,0.0006621314],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.88764626,0.06201549,0.0034631295,0.00032522078,0.0011893756,0.00012117604,0.00028333356,0.0016656806,0.0125175305,0.0001827151,0.0009919261,0.029598095],"study_design_scores_gemma":[0.5490186,0.44133148,0.005721439,0.00001680571,0.00060285267,0.00010232249,0.0000882075,0.0006224608,0.0012278728,0.00013943901,0.0010993929,0.000029199227],"about_ca_topic_score_codex":0.0050788033,"about_ca_topic_score_gemma":0.011201028,"teacher_disagreement_score":0.0050788033,"about_ca_system_score_codex":0.0019770043,"about_ca_system_score_gemma":0.0035666535,"threshold_uncertainty_score":0.014344275},"labels":[],"label_agreement":null},{"id":"W1964191731","doi":"10.1016/j.bmcl.2007.09.014","title":"ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Consiglio Nazionale delle Ricerche","keywords":"Chemistry; Vorinostat; Alkoxy group; Moiety; Ether; Enantiomer; Stereochemistry; Carbon chain; Biological activity; Hydroxamic acid; Histone deacetylase inhibitor; Structure–activity relationship; Histone deacetylase; In vitro; Alkyl; Organic chemistry; Biochemistry; Histone","score_opus":0.00809606463605626,"score_gpt":0.265959513113545,"score_spread":0.2578634484774887,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964191731","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9872012,0.005395407,0.0017090349,0.00006474635,0.000046748915,0.000046026376,0.00022096833,0.000027870177,0.005287963],"genre_scores_gemma":[0.99356866,0.0035980565,0.0012185762,0.000036771573,0.00002388711,0.000013592138,0.00018915166,0.000013522578,0.0013378495],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991906,0.00002398158,0.0000069120188,0.000011971884,0.000013641297,0.000024465115],"domain_scores_gemma":[0.9998568,0.00006551757,0.000027676928,0.000013456318,0.000016222024,0.000020365653],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024059559,0.00019993987,0.00022635925,0.00021121187,0.00009980718,0.00018282032,0.00029765608,0.00014734393,0.0019210944],"category_scores_gemma":[0.000304073,0.00013546227,0.00017423871,0.00022471955,0.00022070124,0.00037243633,0.00013491826,0.0004433089,0.00032713395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0032487256,0.0003262548,0.00065905467,0.00018021472,0.00006241932,0.00025091015,0.00009886759,0.002608472,0.9677732,0.0023103654,0.00023747294,0.02224401],"study_design_scores_gemma":[0.00036470132,0.0051016957,0.0017734293,0.000017590746,0.000111232184,0.00023923402,0.00004825372,0.003732126,0.98200005,0.0003588921,0.0062297056,0.00002317335],"about_ca_topic_score_codex":0.0004988848,"about_ca_topic_score_gemma":0.0005630304,"teacher_disagreement_score":0.0019210944,"about_ca_system_score_codex":0.00018975415,"about_ca_system_score_gemma":0.00013220211,"threshold_uncertainty_score":0.006426692},"labels":[],"label_agreement":null},{"id":"W1964233786","doi":"10.1002/dvdy.21626","title":"Histone deacetylases 1 and 2 are expressed at distinct stages of neuro‐glial development","year":2008,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Histone deacetylase 2; Chromatin; Epigenetics; Histone; HDAC1; Neural stem cell; Neuroblast; Epigenetic regulation of neurogenesis; Histone deacetylase; Neural development; Demethylase; Acetylation; Neuroscience; Gene silencing; Cell biology; Chromatin remodeling; Neurogenesis; Genetics; Stem cell; Gene","score_opus":0.013865693243615258,"score_gpt":0.25083883078036323,"score_spread":0.23697313753674798,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964233786","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9398331,0.035953335,0.010498527,0.00030062694,0.00011840718,0.00006789508,0.0018758365,0.00027995335,0.011072412],"genre_scores_gemma":[0.96709096,0.014155438,0.0056375894,0.00012123143,0.000035579655,0.000042735464,0.0016041443,0.000033649536,0.0112787215],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998796,0.000007231244,0.0000066002804,0.000039191105,0.000029430677,0.00003791992],"domain_scores_gemma":[0.9999193,0.0000071975915,0.00003717941,0.000005702724,0.000014168459,0.000016440716],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000085323474,0.00038942005,0.00026740503,0.00042020975,0.00024278105,0.0006365815,0.00019704875,0.00027030025,0.0012792416],"category_scores_gemma":[0.0001290898,0.00025734163,0.0002375415,0.00030380845,0.00027976732,0.0002890509,0.00018604084,0.00037788102,0.00049917283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021107285,0.0000114106515,0.003068299,0.0000719528,0.000016304262,0.00013683888,0.000064505584,0.000058803842,0.98600847,0.000612611,0.00015116781,0.009588531],"study_design_scores_gemma":[0.00002584381,0.00027420162,0.122176565,0.000037478938,0.00008248988,0.0011449495,0.00018581726,0.00039883854,0.8473829,0.00048201697,0.027787631,0.000021128537],"about_ca_topic_score_codex":0.0021674733,"about_ca_topic_score_gemma":0.004632666,"teacher_disagreement_score":0.0021674733,"about_ca_system_score_codex":0.000567313,"about_ca_system_score_gemma":0.00031962077,"threshold_uncertainty_score":0.004309714},"labels":[],"label_agreement":null},{"id":"W1966248219","doi":"10.1158/1078-0432.ccr-08-0469","title":"Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Vorinostat; Sorafenib; Histone deacetylase inhibitor; Cancer research; Histone deacetylase; Caspase 8; Chemistry; Programmed cell death; Apoptosis; Caspase 3; Biology; Histone; Biochemistry; Hepatocellular carcinoma","score_opus":0.1058552604124676,"score_gpt":0.4521050103355005,"score_spread":0.3462497499230329,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966248219","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9922587,0.0031552082,0.0022436306,0.00014463764,0.000044561104,0.000077206016,0.00013845965,0.00008631454,0.001851359],"genre_scores_gemma":[0.99659014,0.00077467604,0.0010780739,0.00003365588,0.000013592266,0.000044765315,0.00016306172,0.000003915431,0.0012981681],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998684,0.000020589494,0.000011750038,0.000018293525,0.00003985474,0.000041059753],"domain_scores_gemma":[0.9999391,0.000008245351,0.000023225552,0.0000061431106,0.0000065025793,0.000016680147],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011893599,0.00037463327,0.00034410722,0.00013719716,0.000107358064,0.0003222945,0.00017733614,0.00016237526,0.0012788214],"category_scores_gemma":[0.00010037412,0.00008439362,0.00024433996,0.00012267446,0.00020152518,0.00020953079,0.00020357153,0.00030093236,0.00027937815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00065538747,0.00012019064,0.0004146065,0.00011658379,0.000018615838,0.00014200572,0.000015327374,0.00025781413,0.99041677,0.00017655377,0.00012230198,0.007543816],"study_design_scores_gemma":[0.00016934327,0.0019334271,0.0028370686,0.0000064712544,0.000045586647,0.0006538201,0.00003007122,0.001277425,0.9890933,0.0000736093,0.0038745196,0.0000053437548],"about_ca_topic_score_codex":0.00017894314,"about_ca_topic_score_gemma":0.00050232233,"teacher_disagreement_score":0.0012788214,"about_ca_system_score_codex":0.00028938564,"about_ca_system_score_gemma":0.0002636417,"threshold_uncertainty_score":0.004278064},"labels":[],"label_agreement":null},{"id":"W1966796326","doi":"10.1038/bjc.2013.691","title":"HDAC inhibitor confers radiosensitivity to prostate stem-like cells","year":2013,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Radioresistance; Radiosensitivity; Stem cell; Cancer research; Trichostatin A; Comet assay; Biology; Prostate cancer; Cancer stem cell; Population; Prostate; Molecular biology; Pathology; DNA damage; Histone deacetylase; Cell culture; Radiation therapy; Cancer; Histone; Medicine; Cell biology; Internal medicine; Genetics; DNA","score_opus":0.0072465360454552165,"score_gpt":0.259111076767119,"score_spread":0.25186454072166375,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966796326","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9916998,0.0032258455,0.001352108,0.000075983764,0.000041016992,0.000050516228,0.0008491841,0.00022438845,0.0024811993],"genre_scores_gemma":[0.9934896,0.0011642815,0.0008137535,0.000066244946,0.000019974263,0.000036085512,0.0018426767,0.000026125168,0.0025411653],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990404,0.000009413795,0.000011655922,0.000019378198,0.000024066676,0.00003141833],"domain_scores_gemma":[0.99985194,0.000041266154,0.000021279222,0.000024327002,0.000014780368,0.00004636056],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009543329,0.00027842383,0.00032499465,0.00028963736,0.00010308748,0.00024342471,0.00020866093,0.00020191312,0.003814764],"category_scores_gemma":[0.00009760877,0.00013006394,0.00035950384,0.00014999021,0.00011828972,0.00008584137,0.00017370174,0.0005716686,0.0006794565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018505234,0.00008866707,0.00042684472,0.00006627418,0.000015353373,0.000054276712,0.000012819967,0.000076030694,0.996523,0.000046977464,0.00011493756,0.002389728],"study_design_scores_gemma":[0.000032378906,0.0013954857,0.013760182,0.0000087489225,0.000051044743,0.00036443453,0.000021465905,0.00065791496,0.98076093,0.000029922983,0.002911639,0.000005814371],"about_ca_topic_score_codex":0.0006640447,"about_ca_topic_score_gemma":0.00095018477,"teacher_disagreement_score":0.003814764,"about_ca_system_score_codex":0.00016703665,"about_ca_system_score_gemma":0.00020819293,"threshold_uncertainty_score":0.0127616525},"labels":[],"label_agreement":null},{"id":"W1970421873","doi":"10.1038/onc.2010.204","title":"EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Hokkaido University; Michael Smith Health Research BC; Arthritis Society","keywords":"Cancer research; Biology; Synovial sarcoma; PTEN; EGR1; Tensin; Histone deacetylase inhibitor; Histone deacetylase; Sarcoma; Cell biology; Downregulation and upregulation; Histone; Signal transduction; Medicine; Pathology; PI3K/AKT/mTOR pathway","score_opus":0.010296868937699532,"score_gpt":0.28049297299630316,"score_spread":0.2701961040586036,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970421873","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99235994,0.0019322922,0.001987794,0.0001898211,0.000039995204,0.0000174205,0.00028678426,0.00017582792,0.0030102453],"genre_scores_gemma":[0.99674976,0.0007547688,0.0003993772,0.00002729508,0.0000059177482,0.000011669191,0.00024031116,0.00001293934,0.001797902],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976784,0.000028916973,0.000018499399,0.00003130442,0.00007436866,0.000079082696],"domain_scores_gemma":[0.99989843,0.000022713239,0.00003163433,0.000016910883,0.0000061816772,0.000024088586],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022535812,0.0004173291,0.00022711114,0.00040433806,0.00019964897,0.00045623674,0.00024122154,0.00016653682,0.0014269854],"category_scores_gemma":[0.00018151465,0.00018708824,0.00026503895,0.0003183344,0.0003921483,0.00032735203,0.00027915314,0.00071758,0.000432674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035574674,0.00006687207,0.0004096682,0.00004507459,0.000019520157,0.00014272776,0.000024860003,0.00029805797,0.9946859,0.00067727925,0.00017411586,0.0031001067],"study_design_scores_gemma":[0.00003634696,0.00024273577,0.0023650473,0.0000032051785,0.000023137798,0.00024912276,0.000034694687,0.00075338874,0.9942932,0.00013064437,0.0018642675,0.0000042116612],"about_ca_topic_score_codex":0.0009926345,"about_ca_topic_score_gemma":0.0022024612,"teacher_disagreement_score":0.0014269854,"about_ca_system_score_codex":0.00047039686,"about_ca_system_score_gemma":0.00041059285,"threshold_uncertainty_score":0.0047737956},"labels":[],"label_agreement":null},{"id":"W1971648238","doi":"10.1016/j.ejcb.2012.07.001","title":"ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion","year":2012,"lang":"en","type":"article","venue":"European Journal of Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institut Curie; Institute of Cancer Research; Institut national de la recherche scientifique; Institut National Du Cancer; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Cortactin; Invadopodia; Cell biology; Acetylation; HDAC6; Extracellular matrix; Endosome; Podosome; Stromal cell; Chemistry; Cell migration; Cancer cell; Matrix metalloproteinase; Biology; Histone deacetylase; Cell; Biochemistry; Cancer research; Histone; Cancer; Cytoskeleton; Intracellular","score_opus":0.0073103938643914665,"score_gpt":0.22578162397706092,"score_spread":0.21847123011266945,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971648238","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9842589,0.007301559,0.004078077,0.00030382743,0.00011609773,0.000023173798,0.00063594716,0.00021027075,0.0030721822],"genre_scores_gemma":[0.9914431,0.0014229766,0.0017764526,0.00007140325,0.000025534264,0.00002252583,0.0007782399,0.00008747367,0.004372291],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997621,0.000020675257,0.000019803942,0.000053673582,0.000048214657,0.00009547158],"domain_scores_gemma":[0.99979585,0.000013841098,0.00007632989,0.000015576901,0.000033086868,0.0000653345],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021403667,0.00036316487,0.00035378497,0.00036228567,0.00033341034,0.00073616963,0.0004099843,0.00027062054,0.0020305899],"category_scores_gemma":[0.00022007988,0.000409843,0.0004295089,0.00024933473,0.00040753,0.00049942627,0.00041504644,0.00054015033,0.001044484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006650274,0.00002884135,0.0028763865,0.0000470514,0.000032763728,0.000096589065,0.000038564263,0.00015538288,0.989954,0.00044954833,0.00022429526,0.005431524],"study_design_scores_gemma":[0.00006344984,0.00015187608,0.03592846,0.0000072179805,0.00004704022,0.00048933015,0.00012359643,0.0017907087,0.95555496,0.0002687954,0.0055612433,0.00001331655],"about_ca_topic_score_codex":0.0014089689,"about_ca_topic_score_gemma":0.0036252732,"teacher_disagreement_score":0.0020305899,"about_ca_system_score_codex":0.0009431932,"about_ca_system_score_gemma":0.00041433368,"threshold_uncertainty_score":0.0068434477},"labels":[],"label_agreement":null},{"id":"W1972132259","doi":"10.1517/17460441.2013.798296","title":"Advances in the development of hybrid anticancer drugs","year":2013,"lang":"en","type":"review","venue":"Expert Opinion on Drug Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Anticancer drug; Drug discovery; Histone deacetylase; Computational biology; Pharmacology; Medicine; Drug; Bioinformatics; Biology; Histone; DNA","score_opus":0.032139987382060725,"score_gpt":0.3785754578168257,"score_spread":0.34643547043476497,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972132259","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00048502884,0.99417746,0.0010407274,0.0004505688,0.00027883053,0.000017382508,0.000035083503,0.00001805307,0.003496857],"genre_scores_gemma":[0.0034300764,0.9937285,0.00093988306,0.0003303834,0.00018667088,0.000021779802,0.000058623205,0.0000037062491,0.0013003392],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997118,0.000048274756,0.000027616468,0.000061951905,0.000119685305,0.00003059787],"domain_scores_gemma":[0.99979454,0.00009125649,0.000030063937,0.000008667369,0.00006020008,0.000015312395],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005678545,0.00072213344,0.0011286201,0.001972105,0.00025660978,0.0008870123,0.00069652696,0.0011332117,0.003867107],"category_scores_gemma":[0.00052438537,0.00035924846,0.000622227,0.0014643492,0.00046035962,0.0012988744,0.0006744032,0.0019609774,0.002273916],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007816528,0.00011007208,0.00018387797,0.022355296,0.00010470608,0.0005077571,0.00009876514,0.00089986605,0.013626171,0.013742398,0.020736711,0.9275562],"study_design_scores_gemma":[0.000016337695,0.00010875735,0.00035686663,0.0012784518,0.000054714375,0.0013851469,0.000025865238,0.00020792274,0.0034934164,0.0019504233,0.991104,0.000018188024],"about_ca_topic_score_codex":0.00063796114,"about_ca_topic_score_gemma":0.00092614605,"teacher_disagreement_score":0.003867107,"about_ca_system_score_codex":0.0007373657,"about_ca_system_score_gemma":0.00062598207,"threshold_uncertainty_score":0.0129368305},"labels":[],"label_agreement":null},{"id":"W1972314927","doi":"10.1021/ml100028g","title":"Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools","year":2010,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Vorinostat; Pharmacokinetics; Pharmacology; Inhibitory postsynaptic potential; Chemistry; Alkoxy group; Computational biology; Gene isoform; Biochemistry; Medicine; Histone deacetylase; Histone; Biology; Neuroscience; Organic chemistry","score_opus":0.010222065237996455,"score_gpt":0.2896440705657516,"score_spread":0.27942200532775513,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972314927","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8599697,0.017917229,0.077916086,0.0009976063,0.00016706037,0.00038528224,0.002183192,0.0010931242,0.039370567],"genre_scores_gemma":[0.9643853,0.007123344,0.02567404,0.0000991114,0.000043750464,0.000062992614,0.0008161259,0.000032474032,0.0017628268],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999665,0.0000090955755,0.0000021520152,0.000005090811,0.000011699841,0.000005489643],"domain_scores_gemma":[0.99995565,0.00001833986,0.000011047927,0.0000056513354,0.0000038333196,0.000005432535],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014373659,0.00034440553,0.00041674273,0.00017954134,0.00014623356,0.00039507076,0.0003439742,0.00016446858,0.0029213699],"category_scores_gemma":[0.00020401845,0.00016000665,0.00026129492,0.00021631543,0.00027346628,0.00037215278,0.00019181901,0.0005462908,0.00049859314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014146204,0.0003268614,0.0015209856,0.0011547689,0.00010504203,0.00089828623,0.00010397004,0.11614793,0.6996375,0.051520128,0.0015011103,0.12566887],"study_design_scores_gemma":[0.0010014224,0.0034497185,0.0029614358,0.00011050654,0.00035202331,0.0016612808,0.000206731,0.23647195,0.6667847,0.019052781,0.06781312,0.00013422217],"about_ca_topic_score_codex":0.00046379946,"about_ca_topic_score_gemma":0.00074638275,"teacher_disagreement_score":0.0029213699,"about_ca_system_score_codex":0.00029217955,"about_ca_system_score_gemma":0.00025359387,"threshold_uncertainty_score":0.009772956},"labels":[],"label_agreement":null},{"id":"W1972338617","doi":"10.1074/jbc.m402475200","title":"Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute","keywords":"Cleavage (geology); Histone deacetylase; Cell biology; HDAC11; Histone deacetylase 5; Chemistry; Histone deacetylase 2; Histone; Biology; Biochemistry; DNA","score_opus":0.027696021112693998,"score_gpt":0.3062608635281548,"score_spread":0.2785648424154608,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972338617","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96254396,0.005163415,0.02565301,0.0002734099,0.000242519,0.00016625652,0.0017418822,0.0002086987,0.004006778],"genre_scores_gemma":[0.9740564,0.001610484,0.011284066,0.00013427703,0.000033168704,0.00006595837,0.004735126,0.000040344083,0.008040192],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976915,0.000035059733,0.000029159544,0.00006350895,0.000046786332,0.00005620612],"domain_scores_gemma":[0.9998362,0.00003669201,0.0000431074,0.000033020493,0.000027975319,0.000022884673],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021969705,0.00043203638,0.00023979589,0.0001681237,0.00014609461,0.00024462037,0.00028948524,0.00023298297,0.0024443192],"category_scores_gemma":[0.00025168326,0.00013981033,0.00048270272,0.00015682958,0.00015460348,0.0001788309,0.00026423784,0.00058934896,0.00072981376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014432809,0.000019671768,0.00025748732,0.000053183627,0.000016515112,0.00006743871,0.000012808236,0.00006802522,0.9964574,0.00017083218,0.00012665977,0.0026055803],"study_design_scores_gemma":[0.000026891894,0.00019030269,0.0016691445,0.00000426696,0.000016631697,0.0004023465,0.000011665682,0.0006173559,0.99242604,0.00007156852,0.004558909,0.00000493794],"about_ca_topic_score_codex":0.00042346795,"about_ca_topic_score_gemma":0.00040296683,"teacher_disagreement_score":0.0024443192,"about_ca_system_score_codex":0.000397472,"about_ca_system_score_gemma":0.00029794054,"threshold_uncertainty_score":0.008177102},"labels":[],"label_agreement":null},{"id":"W1972372000","doi":"10.1002/jcp.24311","title":"Dynamic distribution of HDAC1 and HDAC2 during mitosis: Association with F‐actin","year":2013,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Mitosis; HDAC1; Cell biology; Biology; Corepressor; Histone deacetylase 2; Chromatin; Molecular biology; Histone; Genetics; Histone deacetylase; Gene expression; Gene; Repressor","score_opus":0.0023041173488901117,"score_gpt":0.20614973487915247,"score_spread":0.20384561753026237,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972372000","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98396045,0.0077415328,0.0034771175,0.00011449899,0.000035242396,0.000015788515,0.0004125389,0.000053071057,0.0041898526],"genre_scores_gemma":[0.9926018,0.0019175011,0.0013057243,0.000057843354,0.000027568703,0.000022603295,0.0006409815,0.000018263137,0.0034076783],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998981,0.000006031921,0.00000507185,0.000032995526,0.000021165748,0.000036497513],"domain_scores_gemma":[0.99993694,0.000007258391,0.000014912483,0.000005223065,0.000011690996,0.000023982511],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000089343885,0.00017673218,0.00017221551,0.00037931855,0.0003016292,0.00044858982,0.00017714754,0.00022049111,0.0015679589],"category_scores_gemma":[0.000113284375,0.00024412852,0.00016687873,0.00019270887,0.00013163165,0.00023423096,0.00016445934,0.00028796,0.00044605337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016940304,0.000013910261,0.0027915684,0.000034877736,0.000014163354,0.000067183915,0.000030409386,0.000030112631,0.9940673,0.00012362874,0.00008602745,0.0025712769],"study_design_scores_gemma":[0.000039751678,0.00016609926,0.25867957,0.000027421007,0.000056529192,0.00092050736,0.00014404266,0.0016239742,0.72892517,0.00016724403,0.009230629,0.000019145102],"about_ca_topic_score_codex":0.0010685399,"about_ca_topic_score_gemma":0.0017935478,"teacher_disagreement_score":0.0015679589,"about_ca_system_score_codex":0.0004019701,"about_ca_system_score_gemma":0.00013444667,"threshold_uncertainty_score":0.005245328},"labels":[],"label_agreement":null},{"id":"W1972818734","doi":"10.1038/sj.onc.1210565","title":"Irradiation modulates association of NF-Y with histone-modifying cofactors PCAF and HDAC","year":2007,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"PCAF; Biology; Histone acetyltransferase; Transcription factor; Acetylation; P300-CBP Transcription Factors; Molecular biology; Histone deacetylase; HDAC1; Histone; Histone deacetylase 5; Cancer research; Histone Acetyltransferases; Biochemistry; Gene","score_opus":0.007519137143206036,"score_gpt":0.2858267812519997,"score_spread":0.27830764410879366,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972818734","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98994875,0.0051342286,0.0019721878,0.00016052858,0.00007736633,0.000016758262,0.0003067538,0.00008311959,0.0023002531],"genre_scores_gemma":[0.9939375,0.001084302,0.00060050975,0.000045811616,0.00001914006,0.00002156828,0.00066395104,0.00003704726,0.0035899682],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998221,0.000025691561,0.000007964903,0.000036939367,0.000025027844,0.000082328006],"domain_scores_gemma":[0.99982977,0.000050750623,0.000035619232,0.000022861883,0.000016820153,0.00004409627],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015062199,0.0004013616,0.00025590978,0.00021407976,0.00030038515,0.00037153505,0.00032617725,0.00030138285,0.0033183107],"category_scores_gemma":[0.0002668048,0.00024910757,0.00038978292,0.00016469881,0.0003251378,0.00035551214,0.00028249505,0.0006604396,0.00053607195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011281779,0.000046284233,0.00046321398,0.000031089654,0.000013125076,0.000033337637,0.00001694135,0.000030373083,0.9969168,0.00012713383,0.000082768755,0.0011108],"study_design_scores_gemma":[0.00006278832,0.0002378291,0.018914707,0.0000088694505,0.000025396685,0.0001342588,0.000056843164,0.00045356163,0.9780326,0.000065327884,0.002000918,0.0000068885556],"about_ca_topic_score_codex":0.0018699985,"about_ca_topic_score_gemma":0.0026825618,"teacher_disagreement_score":0.0033183107,"about_ca_system_score_codex":0.0006447005,"about_ca_system_score_gemma":0.0002772628,"threshold_uncertainty_score":0.011100829},"labels":[],"label_agreement":null},{"id":"W1973011997","doi":"10.1016/j.febslet.2004.06.018","title":"Histone deacetylase inhibitors regulate p21<sup>WAF1</sup> gene expression at the post‐transcriptional level in HepG2 cells","year":2004,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Histone deacetylase; HDAC11; Histone deacetylase 5; Histone; Histone deacetylase 2; Cyclin-dependent kinase; Histone deacetylase inhibitor; Transcriptional regulation; Biology; Cancer research; Regulation of gene expression; Gene expression; Cell biology; Transcription (linguistics); Cell cycle; Cyclin D1; Gene; Genetics","score_opus":0.01311225418876069,"score_gpt":0.2492917286208345,"score_spread":0.23617947443207382,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973011997","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98562706,0.0032700498,0.0019981284,0.0002741505,0.000100328536,0.00002403278,0.000905032,0.00027035875,0.007530807],"genre_scores_gemma":[0.9886057,0.0017116998,0.0006200409,0.000067255205,0.000034379835,0.000024537658,0.0008730405,0.00005275741,0.008010574],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992096,0.000015592985,0.000008421072,0.0000098162045,0.0000202681,0.000024919636],"domain_scores_gemma":[0.9998809,0.00003051931,0.000018036866,0.000020525249,0.000025797617,0.000024270423],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010159737,0.00024909354,0.00021399974,0.0002341731,0.000201885,0.00044364942,0.00010210874,0.000103267135,0.0021735644],"category_scores_gemma":[0.00012587504,0.00010305415,0.00017226215,0.00021812432,0.00019497778,0.00016606983,0.00009613385,0.00030935302,0.0012258703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047531343,0.00005687251,0.00050466834,0.00002841461,0.0000064672586,0.00009380323,0.000028925508,0.000105859115,0.996336,0.00011517678,0.0002413218,0.0020072828],"study_design_scores_gemma":[0.000023016793,0.00020826062,0.004949476,0.0000022661995,0.000009448074,0.00009745335,0.000046922654,0.0005834823,0.9908021,0.000043461554,0.0032304523,0.0000036872311],"about_ca_topic_score_codex":0.0031068765,"about_ca_topic_score_gemma":0.0031273346,"teacher_disagreement_score":0.0031068765,"about_ca_system_score_codex":0.00038226933,"about_ca_system_score_gemma":0.00023959776,"threshold_uncertainty_score":0.0072713494},"labels":[],"label_agreement":null},{"id":"W1973213920","doi":"10.1007/s10735-012-9478-z","title":"Protein expression pattern of human MIER1 alpha, a novel estrogen receptor binding protein","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Histology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Terry Fox Research Institute; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Biology; Immunohistochemistry; Estrogen receptor; Cytoplasm; Staining; Germinal epithelium; Endocrinology; Pathology; Internal medicine; Cell biology; Immunology; Medicine; Cancer","score_opus":0.016902381534507443,"score_gpt":0.28959933627435563,"score_spread":0.2726969547398482,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973213920","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9910006,0.0031960732,0.002239096,0.00013607102,0.000034313638,0.000012552778,0.0007186832,0.00004064735,0.0026220563],"genre_scores_gemma":[0.9841495,0.0016501751,0.00205785,0.00007895345,0.000039634127,0.000027468395,0.002142619,0.000019261917,0.009834462],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999368,0.000006384887,0.0000041208514,0.00002100399,0.000012032373,0.000019550856],"domain_scores_gemma":[0.99990356,0.000023163433,0.00001901921,0.000010202904,0.000014167182,0.000029826087],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008712756,0.00014395082,0.00013217828,0.00046691258,0.00019185359,0.00021588705,0.00012206548,0.00019883455,0.001929135],"category_scores_gemma":[0.0001203852,0.0001494768,0.00015859296,0.00026283856,0.00017251364,0.00016038363,0.00008890204,0.00022552749,0.0006890312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003566469,0.000018015964,0.0013896272,0.000027222732,0.000010516368,0.00017530491,0.0000308319,0.000033608925,0.99626416,0.0001565452,0.00008799984,0.0014494918],"study_design_scores_gemma":[0.00007188639,0.000711991,0.18179312,0.0000186693,0.00013833503,0.005062518,0.000271969,0.0022302775,0.7957183,0.00034891753,0.013614276,0.000019728153],"about_ca_topic_score_codex":0.0006554383,"about_ca_topic_score_gemma":0.0007271538,"teacher_disagreement_score":0.001929135,"about_ca_system_score_codex":0.0002148015,"about_ca_system_score_gemma":0.0001145229,"threshold_uncertainty_score":0.0064535737},"labels":[],"label_agreement":null},{"id":"W1973588440","doi":"10.1007/s00280-013-2224-8","title":"A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer","year":2013,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Novartis Pharmaceuticals Corporation","keywords":"Panobinostat; Medicine; Prostate cancer; Tolerability; Internal medicine; Oncology; Cancer; Clinical endpoint; Prostate-specific antigen; Phases of clinical research; Urology; Adverse effect; Chemotherapy; Clinical trial; Histone deacetylase","score_opus":0.008602750773293795,"score_gpt":0.31324066361341824,"score_spread":0.3046379128401244,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973588440","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9937742,0.0010711346,0.00051918696,0.00046561062,0.00013801607,0.0017125655,0.00080725976,0.00007072308,0.001441267],"genre_scores_gemma":[0.9878236,0.0020015675,0.0017694002,0.00081129576,0.00026950418,0.002115551,0.0021561617,0.00005136709,0.003001511],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9995283,0.00021266057,0.000015024619,0.00008133509,0.000029217148,0.00013355458],"domain_scores_gemma":[0.9992799,0.00011652964,0.00007934719,0.000071542905,0.000036445465,0.0004162268],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001024118,0.0018408289,0.0029958526,0.00057795044,0.00063808885,0.0009822826,0.00088878087,0.0013353034,0.0043046763],"category_scores_gemma":[0.00089185603,0.00082371105,0.0015142397,0.00066680973,0.001271909,0.001070442,0.000372461,0.0037052243,0.00084081164],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.7830135,0.10578672,0.0046064514,0.0004266044,0.00076218107,0.00028044448,0.00025743822,0.0026028238,0.031854823,0.00027409723,0.001921231,0.068213694],"study_design_scores_gemma":[0.4489005,0.53962106,0.006459803,0.000014260266,0.0003006128,0.00015795209,0.00007208582,0.0007532243,0.0021052316,0.00011998394,0.0014705808,0.000024695682],"about_ca_topic_score_codex":0.0025461717,"about_ca_topic_score_gemma":0.005583739,"teacher_disagreement_score":0.0043046763,"about_ca_system_score_codex":0.0008893891,"about_ca_system_score_gemma":0.0021824122,"threshold_uncertainty_score":0.014400601},"labels":[],"label_agreement":null},{"id":"W1974298714","doi":"10.1074/jbc.m100780200","title":"Ca2+ and BMP-6 Signaling Regulate E2F during Epidermal Keratinocyte Differentiation","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; Lawson Health Research Institute; Western University","funders":"","keywords":"Cell biology; Keratinocyte; E2F; Bone morphogenetic protein 2; Chemistry; Signal transduction; Biology; Cell cycle; Cell; Biochemistry; In vitro","score_opus":0.018728921559192015,"score_gpt":0.26643997020348076,"score_spread":0.24771104864428875,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974298714","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99067724,0.004536569,0.002029161,0.00006987148,0.000023730623,0.000026829739,0.00036636653,0.000046622452,0.0022236505],"genre_scores_gemma":[0.9929,0.001493446,0.0016043368,0.000054333308,0.000011070024,0.000033892593,0.0004019893,0.000014455447,0.0034863988],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998621,0.00002111517,0.000010945612,0.000025444748,0.00003262995,0.000047698988],"domain_scores_gemma":[0.9999279,0.000014990656,0.0000148729205,0.0000065437384,0.000012558772,0.000023161589],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012755589,0.00026867463,0.00021517827,0.0003131826,0.0001755662,0.00041529915,0.00016707186,0.000357984,0.0007988102],"category_scores_gemma":[0.0001178376,0.00017463573,0.00023469684,0.00017574221,0.00020014319,0.00027261217,0.00019480793,0.00031251687,0.00044158197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020266377,0.000019682195,0.0005248095,0.000023124154,0.0000026147197,0.0000691654,0.000018247427,0.00004122739,0.99763703,0.00008881657,0.000032868153,0.0013397781],"study_design_scores_gemma":[0.000019819292,0.00009726655,0.01758957,0.000007666917,0.000009901252,0.00020756174,0.000065618995,0.0006325746,0.9793114,0.00008057907,0.0019726309,0.000005480939],"about_ca_topic_score_codex":0.001175845,"about_ca_topic_score_gemma":0.0018193386,"teacher_disagreement_score":0.001175845,"about_ca_system_score_codex":0.00036422635,"about_ca_system_score_gemma":0.00018214139,"threshold_uncertainty_score":0.0026723146},"labels":[],"label_agreement":null},{"id":"W1974414813","doi":"10.1016/j.clml.2011.05.021","title":"509 The OPAL Study: A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of Tosedostat (CHR-2797) in Elderly Subjects with Treatment Refractory or Relapsed Acute Myeloid Leukemia","year":2011,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Refractory (planetary science); Myeloid leukemia; Internal medicine; Safety profile; Oncology; Phases of clinical research; Adverse effect; Clinical trial","score_opus":0.04674116976032461,"score_gpt":0.36483350137479786,"score_spread":0.31809233161447326,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974414813","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9941299,0.001111888,0.00031883494,0.00026071808,0.00006522311,0.0008220662,0.0014264097,0.000073782954,0.0017911433],"genre_scores_gemma":[0.9881295,0.0018964448,0.0011113052,0.0010176662,0.00017161365,0.0011304918,0.003787195,0.00003977999,0.0027160333],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.9997254,0.00012953344,0.000011604398,0.00003514262,0.000029163775,0.00006917601],"domain_scores_gemma":[0.9995116,0.0000816939,0.00008255699,0.00004182492,0.000024080093,0.00025824967],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00084287405,0.0012226484,0.0016896494,0.00046167691,0.00027925274,0.00065982336,0.0006933169,0.0007962859,0.0039142547],"category_scores_gemma":[0.0005929891,0.00041290044,0.0009797586,0.00040895026,0.0010130005,0.00060012616,0.0003557602,0.0024934262,0.0007927959],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.8103725,0.03979305,0.01356274,0.00078206207,0.0019942657,0.0004221309,0.00022080321,0.0017261542,0.044184383,0.0005623886,0.0052423915,0.08113707],"study_design_scores_gemma":[0.71278685,0.25117895,0.02520633,0.000032298343,0.0010159172,0.0003689215,0.00009293991,0.0008515906,0.0037179405,0.00027162567,0.004433036,0.00004357826],"about_ca_topic_score_codex":0.0011672288,"about_ca_topic_score_gemma":0.0032211456,"teacher_disagreement_score":0.0039142547,"about_ca_system_score_codex":0.00058122294,"about_ca_system_score_gemma":0.001213752,"threshold_uncertainty_score":0.013094544},"labels":[],"label_agreement":null},{"id":"W1975306954","doi":"10.1002/bdrb.20236","title":"Characterization of valproic acid‐initiated homologous recombination","year":2010,"lang":"en","type":"article","venue":"Birth Defects Research Part B Developmental and Reproductive Toxicology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Homologous recombination; DNA damage; DNA repair; Histone; Reactive oxygen species; Chemistry; Molecular biology; Acetylation; Histone deacetylase; DNA; Cell biology; Biology; Biochemistry; Gene","score_opus":0.04178921823130994,"score_gpt":0.3258206109205921,"score_spread":0.2840313926892822,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975306954","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96492165,0.0025329052,0.027517052,0.00007061327,0.000031739113,0.00014889457,0.00196371,0.000174005,0.0026393742],"genre_scores_gemma":[0.9681161,0.0012825746,0.020356104,0.000048581787,0.000010676523,0.00010329726,0.006021815,0.00012894525,0.003931856],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99975437,0.000039330378,0.000023530101,0.000059957427,0.0000846434,0.000038249404],"domain_scores_gemma":[0.999448,0.00012343546,0.00019093769,0.000060289392,0.000118499614,0.000058754395],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025794862,0.00033465453,0.00020098481,0.0005516904,0.000111819616,0.00027693913,0.00033941437,0.000309223,0.0017755547],"category_scores_gemma":[0.00047166552,0.00012190298,0.00033399859,0.0003898303,0.0001410854,0.000175521,0.00014197476,0.0004826252,0.0006739644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000048249,0.000017582015,0.00037654274,0.0000347127,0.000005568803,0.000049897128,0.000020806805,0.00005602386,0.9979128,0.000038886097,0.000012972302,0.001425906],"study_design_scores_gemma":[0.00000546642,0.0002426945,0.006185845,0.000010443861,0.000020199455,0.0004532777,0.000034163662,0.0007905292,0.98890746,0.00003684589,0.003308781,0.0000043475416],"about_ca_topic_score_codex":0.0004424706,"about_ca_topic_score_gemma":0.00036595474,"teacher_disagreement_score":0.0017755547,"about_ca_system_score_codex":0.000185021,"about_ca_system_score_gemma":0.00017901346,"threshold_uncertainty_score":0.0059398413},"labels":[],"label_agreement":null},{"id":"W1975382383","doi":"10.1158/1538-7445.am10-1576","title":"Abstract 1576: Molecular targeting of histone deacetylase 2 for treatment of human hepatocellular carcinoma","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Histone deacetylase 2; Gene silencing; Cancer research; Biology; Histone deacetylase; Cell growth; Molecular biology; Cell culture; Gene expression; Small interfering RNA; Chemistry; Histone; Transfection; Gene; Biochemistry; Genetics","score_opus":0.04699315977972056,"score_gpt":0.4171567364785402,"score_spread":0.3701635766988196,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975382383","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85376626,0.08879936,0.02518442,0.0016783401,0.0017629132,0.00076267205,0.0043537416,0.0011460736,0.022546172],"genre_scores_gemma":[0.92259884,0.025720006,0.014785911,0.0007600012,0.00028271123,0.0004954927,0.00657066,0.000111692796,0.028674595],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999145,0.0000132291325,0.000008713356,0.000014951978,0.000033552205,0.000015079943],"domain_scores_gemma":[0.99997723,0.0000016162537,0.0000047513445,0.0000025315019,0.000006996544,0.000006764257],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019636698,0.00046258394,0.0005268498,0.00031573538,0.00011108663,0.00018426131,0.00023079019,0.0003143816,0.0033766748],"category_scores_gemma":[0.000058037615,0.00011010962,0.0003094368,0.0002691854,0.000101152305,0.00013922101,0.00018223624,0.0004837278,0.00151751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032928592,0.000099763296,0.00017343381,0.00030045252,0.000031022842,0.0000835654,0.000010248792,0.000112007714,0.9852706,0.0001412835,0.0011554962,0.012292747],"study_design_scores_gemma":[0.00022720033,0.0014750767,0.0026514134,0.000022408474,0.00008029529,0.00050898636,0.000012631591,0.00068195595,0.96829146,0.00006577022,0.025971256,0.000011582194],"about_ca_topic_score_codex":0.0003978029,"about_ca_topic_score_gemma":0.0006288952,"teacher_disagreement_score":0.0033766748,"about_ca_system_score_codex":0.0002561661,"about_ca_system_score_gemma":0.0002737718,"threshold_uncertainty_score":0.011296034},"labels":[],"label_agreement":null},{"id":"W1975659995","doi":"10.1016/j.neuroscience.2014.02.028","title":"Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson’s disease","year":2014,"lang":"en","type":"article","venue":"Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Rotenone; Neuroprotection; Parkinson's disease; Neuroscience; Valproic Acid; Huntington's disease; Biology; Pharmacology; Medicine; Disease; Epilepsy; Internal medicine; Biochemistry; Mitochondrion","score_opus":0.015279338906786358,"score_gpt":0.2640438957046035,"score_spread":0.24876455679781717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975659995","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99437684,0.002223869,0.00083829794,0.00038445208,0.0001799677,0.00004641441,0.0004169737,0.00016902902,0.0013641194],"genre_scores_gemma":[0.9930992,0.0020322874,0.0011555135,0.00008418159,0.000042411033,0.00006996206,0.0004072758,0.000030216836,0.0030788549],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997489,0.000046816094,0.0000336703,0.000056790384,0.00004416029,0.00006959126],"domain_scores_gemma":[0.9997776,0.000016160198,0.00006715786,0.000031266827,0.000025213854,0.00008255621],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035400715,0.0012204784,0.0010058801,0.00086437183,0.00064121105,0.0005829511,0.00064581266,0.0012018243,0.0014973747],"category_scores_gemma":[0.0002100775,0.00046820173,0.00057373935,0.0005537188,0.0010351188,0.0010287914,0.00030967998,0.0021632644,0.00040337193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.014602168,0.00060491817,0.00040870896,0.00023652072,0.000120771976,0.00053739204,0.00015396361,0.00034683073,0.97577477,0.0004078088,0.00042776283,0.0063783177],"study_design_scores_gemma":[0.0012877367,0.011633716,0.0044465573,0.000044667988,0.000258369,0.0005965349,0.0002343408,0.0014450556,0.9775853,0.0003377566,0.0020929056,0.000036971145],"about_ca_topic_score_codex":0.0025879622,"about_ca_topic_score_gemma":0.0047318577,"teacher_disagreement_score":0.0025879622,"about_ca_system_score_codex":0.00063474075,"about_ca_system_score_gemma":0.00086776685,"threshold_uncertainty_score":0.005145848},"labels":[],"label_agreement":null},{"id":"W1975837044","doi":"10.1074/jbc.m710177200","title":"Lysophosphatidic Acid Protects Cancer Cells from Histone Deacetylase (HDAC) Inhibitor-induced Apoptosis through Activation of HDAC","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; Research Manitoba","funders":"National Cancer Institute; CancerCare Manitoba Foundation; Leukemia and Lymphoma Society","keywords":"Lysophosphatidic acid; Histone deacetylase; Chemistry; Apoptosis; Histone deacetylase inhibitor; Cancer research; Histone deacetylase 5; Cancer cell; Cell biology; Cancer; HDAC11; Histone; Biochemistry; Biology; Medicine; DNA; Internal medicine","score_opus":0.03740312464121171,"score_gpt":0.29880034202965616,"score_spread":0.26139721738844446,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975837044","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.965421,0.023186324,0.0057986905,0.00038280373,0.00023545403,0.00010172477,0.0010019392,0.0004129723,0.003459099],"genre_scores_gemma":[0.98062575,0.010745944,0.0031679638,0.00017151104,0.000070091235,0.00009102908,0.0017836596,0.000023623565,0.0033204728],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998795,0.00001844099,0.000020935955,0.000019795882,0.000027354501,0.000033979686],"domain_scores_gemma":[0.99993384,0.000007601912,0.00001916936,0.000013701919,0.0000102413505,0.000015410595],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012260699,0.0005308942,0.00046190934,0.00027934858,0.00018632629,0.00022373121,0.0001864667,0.00025488366,0.0015625888],"category_scores_gemma":[0.00011576988,0.00017941948,0.0003996363,0.00023550738,0.00018490566,0.00018140183,0.00019949903,0.00081052864,0.00048151452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005672374,0.0001106044,0.0003008923,0.0001520393,0.000044506734,0.0000461033,0.0000122733545,0.000080870224,0.99198794,0.00007476955,0.00016633865,0.0064564315],"study_design_scores_gemma":[0.00012202981,0.0010651996,0.0035182058,0.000013497327,0.000054079745,0.00021537743,0.000017423517,0.00032896994,0.99068767,0.000052820844,0.0039187404,0.000005951629],"about_ca_topic_score_codex":0.00066603074,"about_ca_topic_score_gemma":0.0010595684,"teacher_disagreement_score":0.0015625888,"about_ca_system_score_codex":0.00025872028,"about_ca_system_score_gemma":0.0003816121,"threshold_uncertainty_score":0.005227387},"labels":[],"label_agreement":null},{"id":"W1976129710","doi":"10.1615/critreveukargeneexpr.v10.i3-4.70","title":"Control of Chromatin Remodeling","year":2000,"lang":"en","type":"review","venue":"Critical Reviews in Eukaryotic Gene Expression","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chromatin remodeling; Chromatin; Histone-modifying enzymes; Cell biology; Bivalent chromatin; ChIA-PET; Chromatin structure remodeling (RSC) complex; Histone code; Histone; Chemistry; Biology; Genetics; Gene; Nucleosome","score_opus":0.048660002923147753,"score_gpt":0.3879164960977763,"score_spread":0.3392564931746285,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1976129710","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.005622477,0.9613675,0.011257126,0.0006422879,0.00085177174,0.00006571454,0.00027247117,0.00023493278,0.019685816],"genre_scores_gemma":[0.10268834,0.86314076,0.008177988,0.0007680135,0.00062547287,0.00014216702,0.00073165435,0.00005140176,0.023674142],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9996062,0.00005703318,0.000024109764,0.00013765032,0.00012381497,0.000051234372],"domain_scores_gemma":[0.9998437,0.000032087562,0.00003639935,0.000021360824,0.000037243528,0.000029270554],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004901201,0.00089525693,0.0010551271,0.00061786186,0.0003618187,0.001272158,0.0011110466,0.00086907344,0.0037748876],"category_scores_gemma":[0.00034810347,0.00025178766,0.00040200283,0.00074743334,0.00076972117,0.0008153446,0.0008423835,0.00094274123,0.005458167],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019421602,0.000054375312,0.00082647667,0.0050605033,0.00010610329,0.0005291484,0.00018433196,0.0009703404,0.42612094,0.030506194,0.014544854,0.5209026],"study_design_scores_gemma":[0.000043162578,0.00017543741,0.0030712832,0.00050634413,0.000055222263,0.0021516567,0.00010799618,0.0005012936,0.122903325,0.0068144137,0.8636359,0.000033921693],"about_ca_topic_score_codex":0.0005279366,"about_ca_topic_score_gemma":0.00058162224,"teacher_disagreement_score":0.0037748876,"about_ca_system_score_codex":0.0007788419,"about_ca_system_score_gemma":0.0005431887,"threshold_uncertainty_score":0.012628257},"labels":[],"label_agreement":null},{"id":"W1976749710","doi":"10.1074/jbc.m401805200","title":"F-actin-dependent Insolubility of Chromatin-modifying Components","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Chromatin; Histone; Acetylation; Histone Acetyltransferases; Biochemistry; Nuclear matrix; Chemistry; Actin; Biophysics; Biology; DNA; Cell biology","score_opus":0.04065274409137346,"score_gpt":0.3037784964581089,"score_spread":0.2631257523667354,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1976749710","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9708863,0.0019703936,0.024898484,0.000113046364,0.000036666846,0.000072260096,0.00037907469,0.00009422785,0.0015494792],"genre_scores_gemma":[0.9794038,0.0016643114,0.013042088,0.0001239838,0.000028110766,0.000069908565,0.002198486,0.000110501176,0.0033587469],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998159,0.000022652524,0.000016343192,0.0000503691,0.00004764873,0.00004714838],"domain_scores_gemma":[0.9997584,0.000082950784,0.000050317045,0.00003742463,0.00003833121,0.000032475044],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021131763,0.00046799786,0.00025769617,0.00025738234,0.00024150343,0.00043856894,0.00021973938,0.00018572889,0.0008048119],"category_scores_gemma":[0.0003268889,0.00016368869,0.00023631398,0.0001943582,0.00027205914,0.00025085936,0.00019315165,0.00062069646,0.0003781008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000017015878,0.0000063026578,0.00020455882,0.000011627039,0.0000042517145,0.000021005373,0.000009974798,0.000010539828,0.9989999,0.000025397072,0.000006754849,0.0006826827],"study_design_scores_gemma":[0.0000027070269,0.00004451118,0.0059592035,0.0000037748798,0.00001168814,0.00018204442,0.000014940409,0.00017246502,0.9926246,0.000029463139,0.0009520469,0.0000024848823],"about_ca_topic_score_codex":0.00041621368,"about_ca_topic_score_gemma":0.0008406394,"teacher_disagreement_score":0.0008048119,"about_ca_system_score_codex":0.00016792808,"about_ca_system_score_gemma":0.00019804706,"threshold_uncertainty_score":0.0026923418},"labels":[],"label_agreement":null},{"id":"W1977031081","doi":"10.1155/2010/632739","title":"Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery","year":2010,"lang":"en","type":"article","venue":"International Journal of Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Acetylation; Epigenetics; Context (archaeology); Lysine; Acetyltransferases; Epigenomics; Histone; Disease; Biology; Chromatin; Medicine; Bioinformatics; Biochemistry; Computational biology; Gene expression; Gene; Internal medicine; Amino acid; DNA methylation","score_opus":0.0048269270784482825,"score_gpt":0.25060102036811827,"score_spread":0.24577409328966998,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977031081","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.35304892,0.5758325,0.029909255,0.005366399,0.0011174317,0.000112748625,0.0014120331,0.00052615895,0.032674577],"genre_scores_gemma":[0.6518231,0.3219808,0.013201174,0.0010834534,0.00043026594,0.0000663002,0.0006536927,0.00004648978,0.010714775],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992347,0.000014764855,0.000007001868,0.000020864161,0.00001955369,0.000014293511],"domain_scores_gemma":[0.9999232,0.0000135670925,0.00002969011,0.000007377777,0.0000138608275,0.000012274673],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809463,0.00028159263,0.0002773368,0.00031007617,0.0002318033,0.0004962381,0.00020518739,0.00032291457,0.0016650145],"category_scores_gemma":[0.0001583524,0.00011102986,0.00024057429,0.00028957662,0.0002499207,0.00031334985,0.00028482464,0.00043241933,0.00045212058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00086745416,0.00015069034,0.0046770233,0.0018519388,0.0001638804,0.00035047194,0.00009863192,0.0003684172,0.81261975,0.005117425,0.0019809806,0.17175327],"study_design_scores_gemma":[0.0001204316,0.0018715551,0.062334996,0.00042296018,0.00038009117,0.0022213263,0.00032979427,0.0009103821,0.64496595,0.006507308,0.27985424,0.00008100175],"about_ca_topic_score_codex":0.0006319387,"about_ca_topic_score_gemma":0.0018199759,"teacher_disagreement_score":0.0016650145,"about_ca_system_score_codex":0.0003033445,"about_ca_system_score_gemma":0.00027020878,"threshold_uncertainty_score":0.005570054},"labels":[],"label_agreement":null},{"id":"W1977529605","doi":"10.1007/s10637-014-0066-9","title":"Phase II trial of vorinostat in advanced melanoma","year":2014,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Cancer Research UK","keywords":"Vorinostat; Clinical endpoint; Medicine; Melanoma; Adverse effect; Nausea; Internal medicine; Oncology; Progressive disease; Response Evaluation Criteria in Solid Tumors; Phases of clinical research; Chemotherapy; Randomized controlled trial; Cancer research; Histone deacetylase; Histone; Biology","score_opus":0.013002947923047731,"score_gpt":0.2994760520324806,"score_spread":0.2864731041094329,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977529605","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98486644,0.0043883743,0.00062126614,0.0015092874,0.00056065683,0.0018758063,0.0016901549,0.00014192614,0.0043460866],"genre_scores_gemma":[0.98013616,0.0038574797,0.0010925129,0.0011866586,0.00032416484,0.0017691469,0.0034028494,0.00004898575,0.008182024],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9997626,0.00009785001,0.000007948768,0.00003482451,0.00001796728,0.00007879711],"domain_scores_gemma":[0.99956673,0.000073332376,0.000044287106,0.00003409323,0.000017553137,0.0002639398],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009829482,0.0014799506,0.0020210855,0.00056644337,0.0005356312,0.0010027732,0.0006998265,0.0011527676,0.0050493916],"category_scores_gemma":[0.0005601037,0.0004722961,0.0012055804,0.0004020216,0.0009770828,0.0008160818,0.00031442926,0.002833804,0.0009922151],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.72033656,0.04620254,0.0044542137,0.001211002,0.001155669,0.0006971311,0.0004192819,0.005264089,0.06652183,0.00095622975,0.010345942,0.14243558],"study_design_scores_gemma":[0.5724859,0.40458873,0.008427967,0.00006373781,0.00033146102,0.00036013633,0.00014322653,0.0020770885,0.0057748705,0.00055162085,0.0051593524,0.000035819852],"about_ca_topic_score_codex":0.0019975225,"about_ca_topic_score_gemma":0.0044155098,"teacher_disagreement_score":0.0050493916,"about_ca_system_score_codex":0.0009938901,"about_ca_system_score_gemma":0.0011962986,"threshold_uncertainty_score":0.016891837},"labels":[],"label_agreement":null},{"id":"W1980007697","doi":"10.3390/metabo4030807","title":"Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide","year":2014,"lang":"en","type":"article","venue":"Metabolites","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton; National Research Council Canada","funders":"Brain Tumour Foundation of Canada; Fondation de la recherche en santé du Nouveau-Brunswick; Université de Moncton; New Brunswick Innovation Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Temozolomide; Histone deacetylase; Acetylation; Histone deacetylase inhibitor; Pharmacology; Cancer research; Nicotinamide phosphoribosyltransferase; Chemistry; Biochemistry; Enzyme; Biology; NAD+ kinase; Histone; Glioblastoma; Gene","score_opus":0.004864825476100741,"score_gpt":0.2315896706629061,"score_spread":0.22672484518680536,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1980007697","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952651,0.0036238872,0.00025227564,0.000056297016,0.00004296093,0.000016417745,0.0002338178,0.000023910903,0.000485325],"genre_scores_gemma":[0.9936035,0.0038447254,0.0010529746,0.000045183584,0.000027393624,0.000033290875,0.0005904326,0.000016060032,0.00078638847],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986875,0.000030736013,0.000014242983,0.000019728499,0.00002650295,0.000040115014],"domain_scores_gemma":[0.9999192,0.0000149537445,0.000015260988,0.000008727068,0.000012425248,0.000029481762],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025349646,0.00033233804,0.00073518255,0.0003524739,0.00017380927,0.00028400248,0.00024155962,0.00019442067,0.00078036863],"category_scores_gemma":[0.00017444833,0.00012996365,0.00039450362,0.00031162554,0.0001835331,0.00022753551,0.00015298963,0.000391501,0.00012479062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.005324866,0.0006410668,0.0016993994,0.00021729275,0.00015760603,0.00012821605,0.00006518378,0.0004400365,0.9759413,0.00008616142,0.0002431545,0.0150557505],"study_design_scores_gemma":[0.00035020255,0.009894011,0.026769845,0.00001922068,0.00043985163,0.00025030738,0.00010870383,0.0015922117,0.95667785,0.000046133264,0.0038327207,0.000018839932],"about_ca_topic_score_codex":0.0019037043,"about_ca_topic_score_gemma":0.008097436,"teacher_disagreement_score":0.0019037043,"about_ca_system_score_codex":0.0003856108,"about_ca_system_score_gemma":0.00030078177,"threshold_uncertainty_score":0.0037852526},"labels":[],"label_agreement":null},{"id":"W1982984638","doi":"10.1021/cb400542w","title":"Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Histone deacetylase; LNCaP; DU145; Prostate cancer; Cancer research; Vorinostat; Antiandrogen; Androgen receptor; Biology; Histone; Acetylation; Cancer; Chemistry; Biochemistry; Genetics","score_opus":0.00699813025288969,"score_gpt":0.27786281961973863,"score_spread":0.27086468936684893,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982984638","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93419087,0.013708901,0.031214517,0.0005373421,0.00016532502,0.0002437183,0.0008099089,0.00086614623,0.018263202],"genre_scores_gemma":[0.97408795,0.005918599,0.012312913,0.00021220792,0.000029521905,0.000092406044,0.0003560259,0.000045412704,0.006944881],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999925,0.000008505288,0.0000027136664,0.000019062398,0.000021790902,0.000022808743],"domain_scores_gemma":[0.99997747,0.0000033027727,0.0000071144423,0.0000032475762,0.0000029969963,0.0000058779656],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008263597,0.00033865467,0.0002743882,0.00018094061,0.00008733269,0.0002770379,0.00025189164,0.00023734974,0.0011733756],"category_scores_gemma":[0.00004477803,0.00019216501,0.00025815307,0.00016947748,0.00016270707,0.00013595063,0.00017404759,0.0004010287,0.00042718102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000046893787,0.000031894997,0.00004532082,0.000053099982,0.000009058538,0.000023844548,0.000009424385,0.00028567528,0.99503833,0.0003692961,0.00015717768,0.0039300346],"study_design_scores_gemma":[0.000018465433,0.0003434344,0.00042690674,0.000003283102,0.000015182705,0.00010223078,0.000005140709,0.0007938953,0.9922052,0.00005030375,0.0060315477,0.0000043763152],"about_ca_topic_score_codex":0.0006018537,"about_ca_topic_score_gemma":0.002274275,"teacher_disagreement_score":0.0011733756,"about_ca_system_score_codex":0.00040676634,"about_ca_system_score_gemma":0.00023400238,"threshold_uncertainty_score":0.0039253235},"labels":[],"label_agreement":null},{"id":"W1984084081","doi":"10.1158/1538-7445.am2014-5540","title":"Abstract 5540: Preclinical investigation of the novel histone deacetylase (HDAC) inhibitor AR-42 in the treatment of cancer-induced cachexia","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Cachexia; Medicine; Skeletal muscle; Vorinostat; Cancer; Internal medicine; Histone deacetylase inhibitor; Lewis lung carcinoma; Weight loss; Histone deacetylase; Cancer research; Endocrinology; Oncology; Biology; Histone; Obesity","score_opus":0.11614954142874488,"score_gpt":0.443476966070967,"score_spread":0.3273274246422221,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984084081","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9802288,0.009428772,0.0015329173,0.00046573998,0.00022917193,0.0005986788,0.002017612,0.0003970227,0.0051012943],"genre_scores_gemma":[0.977983,0.007997978,0.0023877753,0.00028401203,0.00009768437,0.00056766043,0.0038454945,0.000030737807,0.0068055717],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986863,0.000024882902,0.000010137981,0.00001995144,0.00003004647,0.000046352096],"domain_scores_gemma":[0.9998927,0.000009955114,0.000018034549,0.000010441968,0.00001480227,0.00005411446],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037056106,0.0009834587,0.0008119182,0.00047735395,0.00032894252,0.0003989234,0.00063154974,0.00060863135,0.003143912],"category_scores_gemma":[0.00011787052,0.00027196735,0.0006189484,0.00040913004,0.00034360285,0.00030148603,0.00017348558,0.0015254645,0.0007432208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.013873703,0.00942162,0.00080821547,0.0008886442,0.00030697443,0.0003605713,0.00009217298,0.0016175081,0.9340183,0.00037297126,0.0025807878,0.035658542],"study_design_scores_gemma":[0.012821415,0.21668452,0.016407099,0.00016204812,0.00061059755,0.00095027674,0.0001221979,0.003396856,0.7326435,0.00019450743,0.015947087,0.000059999795],"about_ca_topic_score_codex":0.0013233073,"about_ca_topic_score_gemma":0.0028715557,"teacher_disagreement_score":0.003143912,"about_ca_system_score_codex":0.0003039571,"about_ca_system_score_gemma":0.0007990089,"threshold_uncertainty_score":0.010517418},"labels":[],"label_agreement":null},{"id":"W1984339533","doi":"10.1016/j.bbagrm.2012.10.005","title":"αNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression","year":2012,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"Shriners Hospitals for Children","keywords":"Myogenin; Chromatin immunoprecipitation; Promoter; Myogenesis; C2C12; Corepressor; Molecular biology; Histone deacetylase; Biology; MyoD; Osteocalcin; Cell biology; Immunoprecipitation; Myocyte; Transcription factor; Chemistry; Gene expression; Repressor; Histone; Gene; Biochemistry","score_opus":0.009462337946763138,"score_gpt":0.2668073322706374,"score_spread":0.25734499432387425,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984339533","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9877994,0.0020779697,0.00563439,0.00017091926,0.00006713444,0.000016229642,0.00015032664,0.000107896674,0.003975711],"genre_scores_gemma":[0.9916203,0.00052706624,0.0017630112,0.00013657408,0.000017266862,0.000010094778,0.0004399633,0.00005805655,0.0054276744],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999824,0.000020565758,0.000010062476,0.000046774177,0.00004262543,0.000056004217],"domain_scores_gemma":[0.9998203,0.000020734631,0.00005442614,0.000021585416,0.000022983693,0.00005991696],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017265798,0.00031210927,0.00019002391,0.00018737746,0.00023961625,0.00047988354,0.00032645787,0.00015724677,0.0016394164],"category_scores_gemma":[0.00021426496,0.00025270277,0.00029139896,0.00016142016,0.00028819483,0.00025765316,0.0004296221,0.00043741864,0.0006384949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013696539,0.00000959615,0.00039331516,0.000012160972,0.000005451471,0.000029807557,0.000013392796,0.000038157148,0.9981908,0.00024593092,0.000032898883,0.0008914892],"study_design_scores_gemma":[0.000033580392,0.00010837206,0.012741974,0.000006400385,0.000019458246,0.00018588138,0.00006182945,0.0017480318,0.9796907,0.00019005872,0.0052064373,0.0000072047505],"about_ca_topic_score_codex":0.0013980318,"about_ca_topic_score_gemma":0.002800397,"teacher_disagreement_score":0.0016394164,"about_ca_system_score_codex":0.00065828604,"about_ca_system_score_gemma":0.000219758,"threshold_uncertainty_score":0.005484402},"labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low"}],"label_agreement":"agree"},{"id":"W1984391626","doi":"10.1158/1078-0432.tcmusa10-a11","title":"Abstract A11: Regulation of CD133 by the tubulin deacetylase HDAC6 can alter cancer cell state","year":2010,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; HDAC6; Cell biology; Progenitor cell; Cancer research; Acetylation; Stem cell; Histone deacetylase; Molecular biology; Histone; Genetics","score_opus":0.06519240995401616,"score_gpt":0.4615438784333071,"score_spread":0.3963514684792909,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984391626","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9869668,0.0014119569,0.005008021,0.00027148303,0.00011081936,0.000041175586,0.0020540215,0.00024109495,0.0038946378],"genre_scores_gemma":[0.9865137,0.0006121795,0.0027703163,0.0000856587,0.000013518308,0.000035417444,0.0021573785,0.00006310682,0.007748604],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988985,0.000011491982,0.000010513703,0.000027361542,0.000035420355,0.000025381425],"domain_scores_gemma":[0.99993205,0.000012588996,0.00001734558,0.000009806049,0.000009044764,0.000019079684],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000815624,0.00024403822,0.00020919382,0.000121735015,0.00015494513,0.00030963484,0.00018376863,0.00022465015,0.0046293093],"category_scores_gemma":[0.000086217595,0.000095772426,0.00023759516,0.00017910787,0.00016848286,0.00014711411,0.00016399378,0.0005067608,0.0008377495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007055988,0.000016024853,0.00013313068,0.00001901239,0.000003173116,0.00001979434,0.0000041799376,0.000023929142,0.99876654,0.000060320494,0.00006762207,0.00081565924],"study_design_scores_gemma":[0.0000054033126,0.00007409937,0.002161462,0.0000012491581,0.0000051954185,0.00004691635,0.0000059977833,0.0002739807,0.9956605,0.000020421567,0.0017430318,0.0000015614671],"about_ca_topic_score_codex":0.00071682513,"about_ca_topic_score_gemma":0.00089789915,"teacher_disagreement_score":0.0046293093,"about_ca_system_score_codex":0.00032622268,"about_ca_system_score_gemma":0.00014765335,"threshold_uncertainty_score":0.015486598},"labels":[],"label_agreement":null},{"id":"W1984734545","doi":"10.1074/jbc.m109.071274","title":"Histone Deacetylase-3 Activation Promotes Tumor Necrosis Factor-α (TNF-α) Expression in Cardiomyocytes during Lipopolysaccharide Stimulation","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University; Montreal Clinical Research Institute; Lawson Health Research Institute","funders":"Heart and Stroke Foundation of Canada","keywords":"Tumor necrosis factor alpha; HDAC3; Histone deacetylase; Lipopolysaccharide; Cell biology; Chemistry; Reactive oxygen species; Stimulation; Signal transduction; Cancer research; Biology; Histone; Endocrinology; Biochemistry","score_opus":0.017363233577287834,"score_gpt":0.2903776419381526,"score_spread":0.27301440836086477,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984734545","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9848483,0.0073429598,0.0042760577,0.0002983042,0.0002048206,0.000047667538,0.00056375697,0.00008268975,0.00233536],"genre_scores_gemma":[0.99332446,0.002271479,0.0014982015,0.00016816684,0.000044870856,0.000040752806,0.0006831358,0.000017273012,0.0019516972],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984753,0.00001636414,0.000015053186,0.000029572995,0.00003729087,0.000054156568],"domain_scores_gemma":[0.99993277,0.0000061521596,0.000017826871,0.000005579011,0.000011505855,0.000026031743],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014469879,0.00023742375,0.00030441006,0.00014440657,0.00015701649,0.00021986155,0.000109731336,0.00019570044,0.0017658839],"category_scores_gemma":[0.00009036971,0.00011634591,0.00050708523,0.00012645638,0.00016724241,0.00014156947,0.00018492312,0.00060881034,0.0004856708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003561759,0.00003708698,0.00056841946,0.00006971857,0.000013224438,0.00008025905,0.000019157527,0.000022633356,0.9973991,0.00004344525,0.00007789686,0.0013128459],"study_design_scores_gemma":[0.00009530621,0.0007727486,0.032600388,0.000021437894,0.000066949644,0.00057055603,0.000117918105,0.0010743331,0.9606765,0.00010528841,0.003887709,0.000010827012],"about_ca_topic_score_codex":0.00038670303,"about_ca_topic_score_gemma":0.00075041445,"teacher_disagreement_score":0.0017658839,"about_ca_system_score_codex":0.00019853788,"about_ca_system_score_gemma":0.00020889327,"threshold_uncertainty_score":0.005907476},"labels":[],"label_agreement":null},{"id":"W1985031257","doi":"10.4161/cbt.6.5.4007","title":"Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy","year":2007,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources","keywords":"Ovarian cancer; Romidepsin; HDAC3; Histone deacetylase; Cancer research; Biology; Gene silencing; Vorinostat; Cell growth; Small interfering RNA; Cancer; Histone; Cell culture; Gene; Genetics; Transfection","score_opus":0.04738758097787353,"score_gpt":0.37765822412816125,"score_spread":0.3302706431502877,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1985031257","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.39193287,0.50705755,0.029503971,0.026186852,0.0018911203,0.00045520268,0.0011521039,0.00095552445,0.040864818],"genre_scores_gemma":[0.7553597,0.22111894,0.007243493,0.0026731712,0.00051271677,0.00026306784,0.000582628,0.00006832922,0.012177853],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999232,0.000016193622,0.000005928414,0.000013456223,0.0000238737,0.000017295179],"domain_scores_gemma":[0.99993193,0.00001701969,0.000019172066,0.000008437635,0.000009379037,0.000014034558],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003045921,0.0004032153,0.0003508155,0.00027936936,0.00018573066,0.00061185146,0.00034574693,0.0004581705,0.0022119663],"category_scores_gemma":[0.000151015,0.00011640273,0.00027330365,0.0002750401,0.000459042,0.00036178489,0.00018500582,0.0010225173,0.0006186367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006667364,0.000552488,0.0014705521,0.0010050162,0.000056283974,0.00040255257,0.00012140041,0.0006699746,0.8284319,0.010059914,0.006226071,0.1503372],"study_design_scores_gemma":[0.0007769229,0.0043783695,0.013959472,0.00021803174,0.00022199047,0.002376034,0.00024158608,0.0034298883,0.6817289,0.005709575,0.28690436,0.000054807915],"about_ca_topic_score_codex":0.00029680764,"about_ca_topic_score_gemma":0.0007708362,"teacher_disagreement_score":0.0022119663,"about_ca_system_score_codex":0.00055724685,"about_ca_system_score_gemma":0.00044842353,"threshold_uncertainty_score":0.007399738},"labels":[],"label_agreement":null},{"id":"W1986099458","doi":"10.1016/j.cyto.2009.07.429","title":"Role of C/EBPβετα and CREB in IL-10 production by tolerogenic dendritic cells","year":2009,"lang":"en","type":"article","venue":"Cytokine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Druggability; Myeloid leukemia; PI3K/AKT/mTOR pathway; Medicine; Disease; Cancer research; Progenitor cell; Signal transduction; Bioinformatics; Computational biology; Immunology; Biology; Stem cell; Internal medicine; Gene; Genetics","score_opus":0.004803447331828127,"score_gpt":0.2391211303078113,"score_spread":0.23431768297598315,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986099458","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9864108,0.0059667374,0.0023227585,0.00060241803,0.00013514404,0.000035704034,0.00051649084,0.00005618769,0.003953818],"genre_scores_gemma":[0.99441975,0.0011892215,0.001153367,0.000101706995,0.00006185565,0.000040728002,0.00031113732,0.000016488997,0.0027056492],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979264,0.000017277393,0.000010699107,0.000029093177,0.000038286304,0.00011197806],"domain_scores_gemma":[0.99981076,0.000026435253,0.000029093928,0.000024429828,0.000029547862,0.00007972804],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002646203,0.00041048072,0.0002636809,0.0002923919,0.00035952355,0.0005325604,0.00033700644,0.0003729524,0.0022045267],"category_scores_gemma":[0.00022761167,0.00023846212,0.00026874483,0.00015212191,0.00043032054,0.00041114673,0.0003368147,0.0009061072,0.0006345233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012319853,0.000066632885,0.00048151237,0.00006701405,0.000008250454,0.00014455168,0.000028413308,0.000097444994,0.9941273,0.0003890426,0.00008791357,0.0032698496],"study_design_scores_gemma":[0.00031709383,0.00038776267,0.022711286,0.0000373185,0.00004453064,0.00053203944,0.00021288532,0.0011691733,0.9701255,0.00077414495,0.0036739814,0.000014360353],"about_ca_topic_score_codex":0.00094168563,"about_ca_topic_score_gemma":0.001266737,"teacher_disagreement_score":0.0022045267,"about_ca_system_score_codex":0.00070487265,"about_ca_system_score_gemma":0.00051596604,"threshold_uncertainty_score":0.0073748827},"labels":[],"label_agreement":null},{"id":"W1986763134","doi":"10.1158/1535-7163.targ-09-a185","title":"Abstract A185: Phase I clinical, pharmacokinetic, and pharmacodynamic study of SB939, an oral histone deacetylase inhibitor (HDACi), in patients with advanced solid tumors","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nausea; Vomiting; Pharmacokinetics; Pharmacodynamics; Adverse effect; Gastroenterology; Internal medicine; Peripheral blood mononuclear cell; Pharmacology; Colorectal cancer; Cmax; Cancer; Biology; In vitro","score_opus":0.023379375978761066,"score_gpt":0.4074113515472472,"score_spread":0.3840319755684862,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986763134","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.990721,0.0020855402,0.0008878342,0.00028476503,0.00007200969,0.0011413032,0.0021877764,0.00014958724,0.0024701229],"genre_scores_gemma":[0.988751,0.00124359,0.0013966113,0.00043559857,0.00006151507,0.00092308514,0.0033068396,0.000031042477,0.0038507709],"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9998672,0.000036977763,0.000009325595,0.000029493278,0.000024395213,0.000032591335],"domain_scores_gemma":[0.9998419,0.000014019491,0.000031058305,0.000012700049,0.000014336194,0.0000859087],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037918496,0.0008274375,0.0008631324,0.0002603579,0.00032746533,0.0006098677,0.00033140625,0.00045104788,0.0040183384],"category_scores_gemma":[0.00024703023,0.00032731582,0.000638819,0.0003255013,0.0003670258,0.0003099337,0.00023297388,0.0017588792,0.0012884205],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.2903179,0.061744776,0.027833967,0.0012078615,0.0014167599,0.00086281146,0.00042267828,0.0050307433,0.34463227,0.0005959733,0.0164307,0.24950351],"study_design_scores_gemma":[0.12473763,0.75458306,0.061407756,0.0000740783,0.00069038727,0.001132256,0.000116037576,0.0028994463,0.034961466,0.00030315714,0.0190511,0.00004371187],"about_ca_topic_score_codex":0.0009842901,"about_ca_topic_score_gemma":0.0019147643,"teacher_disagreement_score":0.0040183384,"about_ca_system_score_codex":0.00065045623,"about_ca_system_score_gemma":0.00101752,"threshold_uncertainty_score":0.013442695},"labels":[],"label_agreement":null},{"id":"W1986920308","doi":"10.1016/j.bbrc.2007.12.157","title":"Histone acetylation is not an accurate predictor of gene expression following treatment with histone deacetylase inhibitors","year":2008,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"","keywords":"Histone deacetylase; Acetylation; HDAC11; HDAC4; Histone deacetylase 2; Histone; Histone deacetylase 5; Histone H2A; HDAC10; SAP30; Psychological repression; Histone H4; Chromatin; Biology; Chemistry; Gene expression; Biochemistry; Gene","score_opus":0.07304370635978576,"score_gpt":0.3836930815221872,"score_spread":0.31064937516240143,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986920308","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9799193,0.0050690677,0.0086284345,0.00046166405,0.000326612,0.00006864543,0.0024601414,0.00016209038,0.0029040622],"genre_scores_gemma":[0.9894633,0.0016526004,0.0023943435,0.00022994322,0.000096512376,0.00009884596,0.0029101693,0.00004696027,0.0031073731],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99934536,0.00009872344,0.000058952537,0.00013839302,0.00021479218,0.00014376949],"domain_scores_gemma":[0.9992964,0.0002685188,0.00012481606,0.000095262796,0.00012087899,0.000094033254],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005461086,0.0003028602,0.001198017,0.0003521988,0.00031609496,0.0008260069,0.00026761647,0.0005260901,0.0018123026],"category_scores_gemma":[0.00088575896,0.0003678949,0.00046560745,0.00061454513,0.0003679826,0.0003763789,0.00020096757,0.0011821908,0.00083601265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001523326,0.00011338686,0.0061520883,0.00005834757,0.00007412768,0.000030673054,0.00003450201,0.0002848643,0.9860998,0.000044066965,0.00024335242,0.0053413557],"study_design_scores_gemma":[0.000037655995,0.000998397,0.08305087,0.000008739176,0.000098869736,0.0001274773,0.00010102978,0.0027348383,0.91032547,0.00011590281,0.0023832903,0.000017504117],"about_ca_topic_score_codex":0.0012553763,"about_ca_topic_score_gemma":0.003441064,"teacher_disagreement_score":0.0018123026,"about_ca_system_score_codex":0.0003517195,"about_ca_system_score_gemma":0.0003324033,"threshold_uncertainty_score":0.0060628057},"labels":[],"label_agreement":null},{"id":"W1987323243","doi":"10.1159/000113927","title":"Valproic Acid and CEBPα-Mediated Regulation of Adipokine Gene Expression in Hypothalamic Neurons and 3T3-L1 Adipocytes","year":2008,"lang":"en","type":"article","venue":"Neuroendocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Dalhousie University; Nova Scotia Health Research Foundation","keywords":"Trichostatin A; Gene silencing; Endocrinology; Histone deacetylase inhibitor; Internal medicine; Adipokine; Biology; RNA interference; Gene expression; Histone deacetylase; Valproic Acid; Adipose tissue; Regulation of gene expression; Insulin resistance; Histone; Gene; Insulin; RNA; Medicine; Epilepsy; Biochemistry","score_opus":0.014463257373926194,"score_gpt":0.240269646136443,"score_spread":0.2258063887625168,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1987323243","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9925972,0.0025824835,0.0012890074,0.00014996646,0.00007350456,0.000031302752,0.0014922888,0.00005047046,0.0017338214],"genre_scores_gemma":[0.9913327,0.0016978278,0.0020076015,0.00014440567,0.000016429896,0.000118717486,0.001336375,0.000028518563,0.003317272],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987483,0.000013123409,0.0000140107295,0.000036440597,0.000026501519,0.000035108977],"domain_scores_gemma":[0.9999361,0.0000102038985,0.000018665865,0.0000077620425,0.000009718158,0.000017394948],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010405951,0.00033717163,0.00027327967,0.00019859885,0.00019884402,0.00028299593,0.00022487325,0.00022598855,0.0011154021],"category_scores_gemma":[0.00006142203,0.00018142501,0.0005366581,0.00017136734,0.00036631426,0.00016758768,0.00016550768,0.0006090269,0.00032609768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000503985,0.000025863392,0.00020619454,0.000035029996,0.0000073483607,0.000053462525,0.000020390009,0.000041719293,0.9984717,0.00004800423,0.000034047145,0.00055221404],"study_design_scores_gemma":[0.00006167204,0.0004310014,0.011711408,0.000012476268,0.000026985257,0.00017816795,0.000101404024,0.00048776018,0.9851032,0.00006267269,0.0018158352,0.000007446972],"about_ca_topic_score_codex":0.0022400059,"about_ca_topic_score_gemma":0.0039321543,"teacher_disagreement_score":0.0022400059,"about_ca_system_score_codex":0.0005493975,"about_ca_system_score_gemma":0.00032851912,"threshold_uncertainty_score":0.004453957},"labels":[],"label_agreement":null},{"id":"W1989140603","doi":"10.1371/journal.pone.0028563","title":"Dysferlin Interacts with Histone Deacetylase 6 and Increases alpha-Tubulin Acetylation","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":true,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Myogenesis; Cell biology; Dysferlin; Tubulin; Acetylation; Biology; Microtubule; Transmembrane protein; HDAC6; Nocodazole; Histone deacetylase; Chemistry; Myocyte; Histone; Biochemistry; Cytoskeleton; Skeletal muscle; Cell; Receptor; Anatomy","score_opus":0.040559220345588294,"score_gpt":0.2529610074015586,"score_spread":0.2124017870559703,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989140603","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99184954,0.0043197297,0.0017207952,0.0002119057,0.00006705776,0.000019455494,0.0003435648,0.000109228575,0.0013588466],"genre_scores_gemma":[0.9940215,0.0012085079,0.0013517019,0.00012338487,0.000018821616,0.000024484772,0.0005372155,0.00002068298,0.0026937209],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977,0.00003894338,0.000019000769,0.00006135764,0.000055547902,0.000055259938],"domain_scores_gemma":[0.99986863,0.000019709692,0.000045138484,0.000012070949,0.000011113453,0.00004328062],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019991335,0.00040945775,0.00037497326,0.00034353932,0.00022177093,0.00031000256,0.00026560455,0.0003853003,0.0014432392],"category_scores_gemma":[0.00016590064,0.0002449574,0.00027983988,0.00023559137,0.00020642327,0.00020081394,0.00029686678,0.0003562421,0.00048124976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019616465,0.000017120174,0.00036730047,0.000043604552,0.000011690353,0.000070449016,0.000010700328,0.00003428402,0.9981565,0.000052579777,0.00011351666,0.00092600496],"study_design_scores_gemma":[0.000039127724,0.00015778116,0.01235794,0.0000060945463,0.000023171468,0.00033948608,0.000024641753,0.0007472064,0.98270345,0.00003592257,0.0035594143,0.0000057938005],"about_ca_topic_score_codex":0.00068005285,"about_ca_topic_score_gemma":0.0011504758,"teacher_disagreement_score":0.0014432392,"about_ca_system_score_codex":0.0005753565,"about_ca_system_score_gemma":0.00014495647,"threshold_uncertainty_score":0.0048280954},"labels":[],"label_agreement":null},{"id":"W1992432201","doi":"10.1016/j.expneurol.2012.12.006","title":"Vorinostat, a histone deacetylase inhibitor, suppresses dendritic cell function and ameliorates experimental autoimmune encephalomyelitis","year":2012,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Moncton","funders":"U.S. Food and Drug Administration; Natural Science Foundation of Tianjin City; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Vorinostat; Experimental autoimmune encephalomyelitis; Histone deacetylase inhibitor; Encephalomyelitis; Histone deacetylase; Function (biology); Cancer research; Medicine; Immunology; Chemistry; Histone; Multiple sclerosis; Biology; Cell biology; Biochemistry","score_opus":0.009668350442455252,"score_gpt":0.27651723515574456,"score_spread":0.2668488847132893,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992432201","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99053544,0.0034314857,0.0009450483,0.00064142933,0.00017549511,0.00003798462,0.00027805692,0.00037691413,0.00357816],"genre_scores_gemma":[0.99232084,0.0029889073,0.0009262682,0.00015601274,0.00011140534,0.000046607704,0.00041098436,0.000029607581,0.0030093745],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998927,0.00001959012,0.000010322215,0.000009334392,0.000035283712,0.00003272597],"domain_scores_gemma":[0.9999032,0.000016019148,0.000026582564,0.000009315549,0.000008257118,0.000036668407],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017186825,0.0005724235,0.00047472375,0.0005337218,0.00029410262,0.0002742679,0.0003208747,0.00034613677,0.0011974587],"category_scores_gemma":[0.000121638346,0.00016600966,0.00018912106,0.00025247494,0.0005318431,0.00034087364,0.000099899546,0.001130766,0.0003390882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0039040418,0.0005822722,0.00029364528,0.00011933187,0.0000383148,0.00024287326,0.00002511529,0.0003107967,0.9803335,0.00040247495,0.00079599244,0.0129515985],"study_design_scores_gemma":[0.0021107765,0.0089114485,0.007760837,0.000031470427,0.00013791888,0.000916414,0.00009726541,0.002418333,0.9702085,0.000753777,0.006621249,0.000032124444],"about_ca_topic_score_codex":0.0005186442,"about_ca_topic_score_gemma":0.0012964205,"teacher_disagreement_score":0.0011974587,"about_ca_system_score_codex":0.00035348898,"about_ca_system_score_gemma":0.0003851971,"threshold_uncertainty_score":0.004005909},"labels":[],"label_agreement":null},{"id":"W1993943756","doi":"10.1139/o07-145","title":"Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate","year":2007,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Canada Research Chairs; CancerCare Manitoba Foundation","keywords":"Trichostatin A; Histone deacetylase; Histone deacetylase 2; HDAC1; Chromatin immunoprecipitation; Histone deacetylase 5; HDAC11; Chemistry; Histone; Chromatin; Butyrate; Transcription (linguistics); Cell biology; Cancer research; Biochemistry; Biology; Gene expression; Promoter; DNA; Gene","score_opus":0.0064652695707308905,"score_gpt":0.2823154819551071,"score_spread":0.2758502123843762,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993943756","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.975628,0.0073502455,0.009880305,0.0002829571,0.00021796237,0.00022835094,0.0011204643,0.00016580422,0.0051258253],"genre_scores_gemma":[0.9796483,0.005894817,0.0077852253,0.00015648326,0.000068481175,0.00020857365,0.0018487327,0.00005767793,0.0043318584],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996458,0.00006848477,0.00004821907,0.00004573395,0.000093748116,0.000097870114],"domain_scores_gemma":[0.9997657,0.000076564815,0.00004874513,0.000043253844,0.000027647393,0.00003813332],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028142432,0.00060426636,0.00064203655,0.00020645594,0.00013718879,0.00031723888,0.0005064418,0.00023475142,0.0014842715],"category_scores_gemma":[0.00027865858,0.00030369408,0.0004976829,0.00034085978,0.00019110813,0.00019249565,0.00025687294,0.00073387875,0.00064495555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006822137,0.00012620178,0.00018673553,0.0000704829,0.00003925595,0.000038571307,0.000008936837,0.00017324882,0.9959116,0.00011666192,0.000108398766,0.0025377353],"study_design_scores_gemma":[0.000072376984,0.00079909404,0.001096748,0.0000044959675,0.000029132547,0.000118852455,0.000011417101,0.0009434217,0.9950158,0.000029599532,0.0018740006,0.000005005627],"about_ca_topic_score_codex":0.0018311448,"about_ca_topic_score_gemma":0.003039489,"teacher_disagreement_score":0.0018311448,"about_ca_system_score_codex":0.00045088987,"about_ca_system_score_gemma":0.0004905568,"threshold_uncertainty_score":0.004965365},"labels":[],"label_agreement":null},{"id":"W1994713061","doi":"10.1038/ki.2011.39","title":"Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor","year":2011,"lang":"en","type":"article","venue":"Kidney International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Vorinostat; Endocrinology; Histone deacetylase; Histone deacetylase inhibitor; Diabetic nephropathy; Internal medicine; Epidermal growth factor; Kidney disease; Transactivation; Medicine; Renal Hypertrophy; Kidney; Cancer research; Biology; Receptor; Histone; Gene expression","score_opus":0.018705476905336027,"score_gpt":0.26535853795054726,"score_spread":0.24665306104521123,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994713061","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9925167,0.0025996298,0.0015828093,0.0004911816,0.00017563532,0.000022011363,0.00023315476,0.00014283163,0.002236182],"genre_scores_gemma":[0.99250495,0.0015303364,0.0008253598,0.0001236623,0.000034764354,0.000018897104,0.00024212989,0.000020116822,0.004699882],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999025,0.000011775386,0.000008016381,0.000015245198,0.00002201997,0.000040495055],"domain_scores_gemma":[0.9998919,0.000012274838,0.00002752507,0.000018904733,0.00001178036,0.000037637987],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017270868,0.00029562207,0.00037579203,0.00016332869,0.00015636701,0.0003123754,0.00034120816,0.00025099167,0.003360307],"category_scores_gemma":[0.00017938834,0.00014868358,0.00033874152,0.000156343,0.0002578761,0.00024111805,0.00013661962,0.0011899598,0.00034736798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0057466263,0.00057619286,0.0007658628,0.00008018587,0.00008198525,0.0000803143,0.000019873023,0.00016505674,0.9803719,0.0004521822,0.00033496285,0.011324857],"study_design_scores_gemma":[0.0005433213,0.0025072326,0.015498768,0.000011078322,0.00016278995,0.00014811101,0.00007920609,0.0009802951,0.9762998,0.00020314424,0.003553932,0.000012341953],"about_ca_topic_score_codex":0.0010607161,"about_ca_topic_score_gemma":0.002243237,"teacher_disagreement_score":0.003360307,"about_ca_system_score_codex":0.000313991,"about_ca_system_score_gemma":0.00045514925,"threshold_uncertainty_score":0.011241317},"labels":[],"label_agreement":null},{"id":"W1994792821","doi":"10.1016/j.canlet.2009.07.011","title":"Troglitazone inhibits histone deacetylase activity in breast cancer cells","year":2009,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Plant Biotechnology Institute; University of Saskatchewan","funders":"","keywords":"Trichostatin A; Histone deacetylase; Cancer research; Vorinostat; Sodium butyrate; Acetylation; Histone H3; Chemistry; Viability assay; Molecular biology; Biology; Histone; Cell; Biochemistry","score_opus":0.008853389727329256,"score_gpt":0.2975976406272495,"score_spread":0.2887442508999203,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994792821","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97700536,0.0098827155,0.0015552142,0.0017180407,0.0004713424,0.00006979312,0.0015777962,0.00068470585,0.007034991],"genre_scores_gemma":[0.9819534,0.005717188,0.00089436385,0.00029204227,0.00011295929,0.00008220346,0.0020022898,0.00007206026,0.008873547],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977046,0.000032653385,0.000020235542,0.000025212617,0.000048355596,0.00010304789],"domain_scores_gemma":[0.99988353,0.00002997708,0.0000144248115,0.000028670724,0.00001609933,0.000027344022],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195546,0.00044616137,0.0006503958,0.00051807525,0.00036119643,0.00040130137,0.0004811232,0.00043522587,0.0034159399],"category_scores_gemma":[0.00021587634,0.00030200096,0.00036449172,0.0005228853,0.00023700195,0.00018245878,0.00018780353,0.0015399035,0.0013462405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014746616,0.00021061709,0.0003263153,0.00009429741,0.00002470969,0.00011889757,0.000049318747,0.00013045213,0.99086154,0.00011945141,0.0011933562,0.0053964863],"study_design_scores_gemma":[0.00022037946,0.0010975444,0.0037714313,0.0000073910114,0.00003556951,0.00018607166,0.000050094888,0.0004367348,0.9868961,0.000052661657,0.007239916,0.0000061755973],"about_ca_topic_score_codex":0.005096867,"about_ca_topic_score_gemma":0.009605835,"teacher_disagreement_score":0.005096867,"about_ca_system_score_codex":0.00067955593,"about_ca_system_score_gemma":0.0005582628,"threshold_uncertainty_score":0.011427462},"labels":[],"label_agreement":null},{"id":"W1995466174","doi":"10.1073/pnas.0502330102","title":"Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"University of Toronto; National Cancer Institute; University of Pennsylvania; National Institutes of Health; Pennsylvania Department of Health","keywords":"Biology; Effector; Cell biology; Small hairpin RNA; Transcription factor; Carcinogenesis; Cancer research; Gene; Gene knockdown; Molecular biology; Genetics","score_opus":0.024274684280094168,"score_gpt":0.3191018018767027,"score_spread":0.2948271175966085,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1995466174","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9329385,0.031272944,0.0148666,0.0013739755,0.00023649202,0.00017037748,0.0037599802,0.00091791793,0.014463136],"genre_scores_gemma":[0.9623388,0.008241215,0.0049445834,0.00014963343,0.00004953501,0.00007046248,0.0038594224,0.000033939814,0.020312438],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999938,0.000004266793,0.0000028124912,0.000020048921,0.000023298735,0.000011587478],"domain_scores_gemma":[0.9999505,0.0000044592757,0.000012137023,0.0000025146348,0.0000057776147,0.000024583835],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000059377948,0.000454586,0.00014526448,0.00026735992,0.00034894873,0.00025895325,0.00016490923,0.00028099056,0.0018123371],"category_scores_gemma":[0.00007576042,0.000093934075,0.00016677471,0.00019424093,0.00015747349,0.00012508058,0.0002732875,0.00044151608,0.0012187974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000043451848,0.00001997332,0.0004647084,0.000060013725,0.000004659483,0.00015628329,0.000007040341,0.000062507264,0.9928271,0.00025512074,0.00045449293,0.0056446763],"study_design_scores_gemma":[0.000019882646,0.0002444109,0.02545361,0.00001780886,0.000018234243,0.0016854635,0.00003485432,0.0016717165,0.91571903,0.00027142852,0.054853857,0.0000097471575],"about_ca_topic_score_codex":0.00083125173,"about_ca_topic_score_gemma":0.0014199195,"teacher_disagreement_score":0.0018123371,"about_ca_system_score_codex":0.0005522975,"about_ca_system_score_gemma":0.0002415465,"threshold_uncertainty_score":0.0060628653},"labels":[],"label_agreement":null},{"id":"W1995694958","doi":"10.1038/modpathol.2011.157","title":"Histone deacetylase 1 and 2 in mesenchymal tumors","year":2011,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Cancer research; Epigenetics; Biology; HDAC1; Histone deacetylase; Histone deacetylase 2; Mesenchymal stem cell; Chromatin; Histone; Pathology; Gene; Cell biology; Medicine; Genetics","score_opus":0.02214213573929831,"score_gpt":0.2779848022489432,"score_spread":0.2558426665096449,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1995694958","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.2631616,0.701415,0.008223611,0.006290135,0.0012384565,0.000040123672,0.00033710743,0.0001941236,0.019099798],"genre_scores_gemma":[0.77069426,0.2062617,0.0034961866,0.0009948416,0.0013707521,0.000038759663,0.0003632717,0.00002259193,0.01675766],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999472,0.0000109574485,0.0000052113164,0.000009457611,0.00001566875,0.000011482299],"domain_scores_gemma":[0.99995124,0.000013611925,0.000010164697,0.000005015692,0.0000068726117,0.000013038854],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031644083,0.00026770605,0.00018625364,0.000686883,0.00016745878,0.00030432126,0.0003046165,0.00037100696,0.00096033956],"category_scores_gemma":[0.00015472929,0.00016889334,0.00015901618,0.0003768383,0.00039806525,0.00034803874,0.00019994749,0.0006803838,0.00024433507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.006586728,0.0004940923,0.019820428,0.001314791,0.00021387453,0.0064246734,0.00027408815,0.00255323,0.5423643,0.060496964,0.012199162,0.3472576],"study_design_scores_gemma":[0.0005289947,0.0021110307,0.093051724,0.00020521772,0.0005040911,0.030118717,0.00036656306,0.003920321,0.4593128,0.035664983,0.3741072,0.00010845571],"about_ca_topic_score_codex":0.0009612202,"about_ca_topic_score_gemma":0.0012363289,"teacher_disagreement_score":0.0009612202,"about_ca_system_score_codex":0.0004597527,"about_ca_system_score_gemma":0.00034876098,"threshold_uncertainty_score":0.0033357143},"labels":[],"label_agreement":null},{"id":"W1996141260","doi":"10.1139/cjpp-2014-0117","title":"Suberoylanilide hydroxamic acid suppresses inflammation-induced neovascularization","year":2014,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Natural Science Foundation of Guangdong Province","keywords":"Angiogenesis; Corneal neovascularization; Vascular endothelial growth factor; Cancer research; Neovascularization; Thrombospondin 1; Chemistry; Basic fibroblast growth factor; Vascular endothelial growth factor A; Growth factor; Fibroblast growth factor; Cell biology; Biology; Biochemistry; Receptor; VEGF receptors","score_opus":0.0076658658693986555,"score_gpt":0.25312746654253143,"score_spread":0.24546160067313277,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1996141260","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9865253,0.009131896,0.0014698908,0.00019964098,0.00009310635,0.000052233503,0.00014945447,0.0001364031,0.0022420415],"genre_scores_gemma":[0.9932853,0.0036246527,0.000970036,0.000074144795,0.00004673636,0.000026938495,0.00016436756,0.000009669017,0.0017981842],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992085,0.000018472203,0.0000074187383,0.000009684611,0.00001827522,0.000025308971],"domain_scores_gemma":[0.9999348,0.000008058931,0.000020287178,0.000004882323,0.000007807639,0.000024193434],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013039215,0.00033799972,0.00037906572,0.0002680984,0.000121676516,0.00013078876,0.00016208738,0.00018515388,0.0015198983],"category_scores_gemma":[0.00010244394,0.00009878938,0.00019105294,0.00010676441,0.00021261835,0.00018736513,0.00011312796,0.00050776213,0.0001783376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012361883,0.00027788774,0.00020213371,0.000093494156,0.000016333957,0.000069930196,0.000015985357,0.00005590303,0.9896458,0.000067536384,0.000115020506,0.008203867],"study_design_scores_gemma":[0.00028102996,0.0067915535,0.006590844,0.0000099248355,0.000047405807,0.000309322,0.00004053314,0.0006438713,0.9819848,0.000089907066,0.003204276,0.000006534416],"about_ca_topic_score_codex":0.00075781887,"about_ca_topic_score_gemma":0.0016296526,"teacher_disagreement_score":0.0015198983,"about_ca_system_score_codex":0.0001704648,"about_ca_system_score_gemma":0.00024621078,"threshold_uncertainty_score":0.0050845146},"labels":[],"label_agreement":null},{"id":"W1997425755","doi":"10.1016/j.ejphar.2007.01.022","title":"Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation","year":2007,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Melatonin; Valproic Acid; Melatonin receptor; MCF-7; Cell growth; Receptor; Endocrinology; Cancer cell; Internal medicine; Chemistry; Biology; Pharmacology; Cancer; Medicine; Biochemistry; Human breast; Epilepsy","score_opus":0.008154964228286928,"score_gpt":0.2880030048171557,"score_spread":0.27984804058886875,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1997425755","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9932121,0.0038290618,0.00031538543,0.00022885401,0.00017570575,0.000035023713,0.0004590897,0.000073101575,0.001671692],"genre_scores_gemma":[0.9944952,0.0015615938,0.0004945343,0.00006726588,0.00007032348,0.000041048395,0.0006121034,0.0000145774575,0.0026432641],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997044,0.00009271836,0.000033144162,0.000037933492,0.00003751491,0.00009427201],"domain_scores_gemma":[0.9998006,0.000070500624,0.00002641155,0.000029962135,0.000017922937,0.00005458298],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031278963,0.00037549104,0.000608153,0.0003975643,0.00035389327,0.00033598006,0.0002956297,0.00037612088,0.002370229],"category_scores_gemma":[0.00037756376,0.00029534008,0.00051583943,0.00044492373,0.00032753995,0.00028101358,0.00022294991,0.00058009644,0.00049447245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.013536209,0.0006465858,0.0011627713,0.00019495728,0.000078547964,0.00026136325,0.00014433329,0.00035510337,0.9738365,0.0001830621,0.00072180096,0.008878699],"study_design_scores_gemma":[0.0005240195,0.0073996093,0.009981583,0.000018702362,0.00016772517,0.00034497073,0.00017548472,0.0009160746,0.9750938,0.00006657803,0.0052909586,0.000020588024],"about_ca_topic_score_codex":0.0035757823,"about_ca_topic_score_gemma":0.005638539,"teacher_disagreement_score":0.0035757823,"about_ca_system_score_codex":0.00045422345,"about_ca_system_score_gemma":0.0006254203,"threshold_uncertainty_score":0.0079292655},"labels":[],"label_agreement":null},{"id":"W1997835752","doi":"10.1007/s13277-010-0087-8","title":"Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression","year":2010,"lang":"en","type":"article","venue":"Tumor Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Maspin; Protein expression; Methylation; Clinical significance; Cancer research; DNA methylation; Breast carcinoma; VEGF receptors; Breast cancer; Correlation; Biology; Oncology; Medicine; Pathology; Internal medicine; Gene expression; Cancer; Genetics; Gene; Metastasis","score_opus":0.011384547519636535,"score_gpt":0.28741524278189484,"score_spread":0.2760306952622583,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1997835752","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9983646,0.00038644767,0.00021990541,0.00006148968,0.0000073332567,0.0000058063915,0.00010680204,0.000011147096,0.0008364023],"genre_scores_gemma":[0.9995784,0.0000704357,0.00008738671,0.000007411503,0.000013763698,0.000004321706,0.000057127887,0.0000021290969,0.00017892342],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99975723,0.000050389306,0.000031519263,0.00004417725,0.000066739325,0.000049971615],"domain_scores_gemma":[0.9986045,0.00048520297,0.00038451832,0.00008045956,0.00013219369,0.00031325518],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040374705,0.00020748824,0.0002730073,0.00084514276,0.00026227333,0.00038179586,0.0002448794,0.00037799322,0.0016941798],"category_scores_gemma":[0.0018012244,0.0001725069,0.00014665416,0.0005357231,0.00041607983,0.00027073742,0.00019808898,0.00044537763,0.00028858607],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015776604,0.00004804274,0.9615439,0.00002751028,0.000039075272,0.0013594027,0.00010386698,0.00008108353,0.03010533,0.00007342779,0.0000783748,0.0049622934],"study_design_scores_gemma":[0.000011121283,0.0002284536,0.9891557,0.0000031999923,0.000053958178,0.0043521663,0.00016948208,0.00046983472,0.0050711147,0.000107517524,0.00037223438,0.000005232283],"about_ca_topic_score_codex":0.00055046467,"about_ca_topic_score_gemma":0.00063729234,"teacher_disagreement_score":0.0016941798,"about_ca_system_score_codex":0.00022457242,"about_ca_system_score_gemma":0.00021437122,"threshold_uncertainty_score":0.0056675673},"labels":[],"label_agreement":null},{"id":"W1998428972","doi":"10.1155/2014/404078","title":"Romidepsin Used as Monotherapy in Sequence with Allogeneic Stem Cell Transplant in a Patient with Peripheral T-Cell Lymphoma","year":2014,"lang":"en","type":"article","venue":"Case Reports in Hematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital de l'Enfant-Jésus","funders":"Celgene","keywords":"Romidepsin; Medicine; Lymphoma; Transplantation; Cytotoxic T cell; Oncology; Peripheral T-cell lymphoma; Internal medicine; Immunology; Histone deacetylase; T cell; Biology; Immune system; Histone","score_opus":0.010132955747363982,"score_gpt":0.24552884084438395,"score_spread":0.23539588509701997,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1998428972","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98257625,0.0042871237,0.0014235033,0.0047886567,0.00019844493,0.000102327074,0.00010261018,0.00013977414,0.006381339],"genre_scores_gemma":[0.9962684,0.0012450877,0.00058411766,0.0009855195,0.0002130988,0.000009557577,0.000049287442,0.0000117304635,0.0006332198],"study_design_codex":"case_report","study_design_gemma":"case_report","domain_scores_codex":[0.99981254,0.000038347913,0.000029756893,0.000040639898,0.000032192984,0.00004650233],"domain_scores_gemma":[0.99961096,0.000103406004,0.000056086454,0.000018489987,0.000017573193,0.00019351165],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020317051,0.00053822744,0.0007499376,0.0006539311,0.0009422689,0.00060448004,0.0004938709,0.0017212788,0.0006795142],"category_scores_gemma":[0.0009768226,0.0003114889,0.00056973053,0.0005647606,0.00057075126,0.00054923934,0.00041876116,0.0019186513,0.00032637105],"study_design_candidate":"case_report","study_design_consensus":"case_report","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006206147,0.00027479097,0.014326924,0.00007385327,0.000047003217,0.96046555,0.00032373553,0.00052765687,0.0068792617,0.00025920005,0.00090485887,0.0152965225],"study_design_scores_gemma":[0.00014571538,0.0021397225,0.022987304,0.000036223377,0.00009699186,0.96657985,0.00020441426,0.002062857,0.0036279575,0.00040607838,0.0016811988,0.000031745876],"about_ca_topic_score_codex":0.0016042962,"about_ca_topic_score_gemma":0.0033699998,"teacher_disagreement_score":0.0017212788,"about_ca_system_score_codex":0.00091232115,"about_ca_system_score_gemma":0.0005914921,"threshold_uncertainty_score":0.006619394},"labels":[],"label_agreement":null},{"id":"W1998981539","doi":"10.1080/1042819031000149304","title":"Enhancement of Antineoplastic Action of 5-Aza-2′-deoxycytidine by Phenylbutyrate on L1210 Leukemic Cells","year":2003,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Cancer research; Leukemia; Phenylbutyrate; Histone deacetylase; Hypomethylating agent; Azacitidine; Epigenetics; DNA methylation; Deoxycytidine; In vitro; L1210 cells; Chromatin; Biology; Chemistry; Molecular biology; Histone; Pharmacology; DNA; Gene; Immunology; Cancer; Biochemistry; Cytotoxicity; Genetics; Gene expression","score_opus":0.008982724020270715,"score_gpt":0.24542381072931124,"score_spread":0.23644108670904052,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1998981539","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9895175,0.0047789617,0.0015788806,0.000090846086,0.000040420306,0.00007373981,0.0005216949,0.000069589965,0.003328177],"genre_scores_gemma":[0.9935689,0.0019803988,0.001739964,0.00004531085,0.000017725111,0.000044172124,0.00068482594,0.000016946033,0.0019016904],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998229,0.000055377455,0.000018154356,0.000026296426,0.000041612486,0.000035741145],"domain_scores_gemma":[0.999866,0.00003474729,0.000026998476,0.00001771549,0.000021861715,0.00003267601],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683865,0.00049509853,0.000507055,0.000251285,0.00012294522,0.00025954374,0.00023090727,0.00022084796,0.0010916532],"category_scores_gemma":[0.00012509644,0.000119375254,0.0002637654,0.00020209572,0.00013875886,0.00015514043,0.00017121281,0.00046143914,0.00036428744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019628106,0.00005090549,0.00012283506,0.000036862577,0.0000055378323,0.0000262275,0.000015421707,0.00009926941,0.99775594,0.000026312855,0.00002371406,0.0016406742],"study_design_scores_gemma":[0.00001957195,0.00092433015,0.0016658701,0.000004662874,0.000013332688,0.000077909666,0.000010641775,0.0003707339,0.99560225,0.000006259904,0.0013021334,0.0000024030544],"about_ca_topic_score_codex":0.0013078755,"about_ca_topic_score_gemma":0.0014441581,"teacher_disagreement_score":0.0013078755,"about_ca_system_score_codex":0.00017542564,"about_ca_system_score_gemma":0.00023297785,"threshold_uncertainty_score":0.0036519766},"labels":[],"label_agreement":null},{"id":"W1999602199","doi":"10.1039/c4md00211c","title":"Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors","year":2014,"lang":"en","type":"article","venue":"MedChemComm","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Toronto Public Health","funders":"University of Sussex; University of Greenwich","keywords":"Histone deacetylase; Kinase; Chemistry; Pharmacology; Biology; Stereochemistry; Cancer research; Histone; Biochemistry; Gene","score_opus":0.009630478867627353,"score_gpt":0.2785078199228863,"score_spread":0.26887734105525896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999602199","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93503004,0.0058243438,0.031199904,0.00023343676,0.00023195663,0.00040779944,0.0016898772,0.00059757446,0.024785101],"genre_scores_gemma":[0.96911657,0.0020405778,0.01579251,0.00012453222,0.000022722515,0.0002049742,0.0010542573,0.000040581657,0.011603296],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995196,0.0000043650903,0.0000046266805,0.000013567041,0.000011052903,0.000014340165],"domain_scores_gemma":[0.999969,0.0000037200252,0.0000065748727,0.000003884591,0.000004400467,0.00001239714],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000090795555,0.00032265173,0.0002289042,0.00017618971,0.000101821126,0.00021749776,0.0002734345,0.00022745937,0.0017982261],"category_scores_gemma":[0.00006933103,0.00019625,0.00018276297,0.00015410013,0.00010161151,0.00024082972,0.0001856586,0.00040035354,0.000704456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014543626,0.000071251096,0.000103358674,0.00011254295,0.00002630236,0.000077953846,0.000021980743,0.0007092396,0.98833734,0.0011319758,0.00026089375,0.00900184],"study_design_scores_gemma":[0.00006612376,0.0006161616,0.00058212917,0.0000065656777,0.000026399694,0.00011547419,0.000009867009,0.0010958384,0.984412,0.00009340841,0.012964171,0.000011868628],"about_ca_topic_score_codex":0.00031817483,"about_ca_topic_score_gemma":0.000880759,"teacher_disagreement_score":0.0017982261,"about_ca_system_score_codex":0.0003079497,"about_ca_system_score_gemma":0.00014154626,"threshold_uncertainty_score":0.006015599},"labels":[],"label_agreement":null},{"id":"W1999677928","doi":"10.1007/s10495-013-0906-7","title":"Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells","year":2013,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Fludarabine; Protein kinase B; Chronic lymphocytic leukemia; Apoptosis; Cancer research; Programmed cell death; Histone deacetylase inhibitor; Chemistry; Histone deacetylase; Biology; Leukemia; Immunology; Biochemistry; Histone; Chemotherapy","score_opus":0.006296237085782526,"score_gpt":0.22305103051664713,"score_spread":0.2167547934308646,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999677928","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9957087,0.0023623607,0.0005406809,0.00007813513,0.000029857782,0.0000138291525,0.0002240934,0.00005025532,0.000992074],"genre_scores_gemma":[0.99772364,0.0006908616,0.0003507356,0.000028316965,0.000006846591,0.000011689909,0.00023448974,0.000005807796,0.0009476113],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987566,0.00003131854,0.000017199616,0.000018116243,0.000022220756,0.000035522015],"domain_scores_gemma":[0.99994886,0.0000078770345,0.0000123236305,0.000008223263,0.000007782251,0.00001501276],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010628444,0.0002930547,0.000218707,0.00023998161,0.00019650257,0.00023537873,0.00020532087,0.00022062675,0.0013469856],"category_scores_gemma":[0.00010158546,0.00013007969,0.00019498279,0.00019466515,0.00016279274,0.00019342736,0.00013644932,0.00042149454,0.0002090134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001353231,0.00006505216,0.000487581,0.00007576961,0.000017280117,0.00011703954,0.000025287713,0.00009283186,0.994942,0.00015123036,0.00007403242,0.0025987152],"study_design_scores_gemma":[0.00007619837,0.00071001466,0.00496396,0.000006742588,0.00004215758,0.0003693043,0.000040662155,0.0003658263,0.9902778,0.00006192556,0.0030814803,0.000003970376],"about_ca_topic_score_codex":0.0008274276,"about_ca_topic_score_gemma":0.001417026,"teacher_disagreement_score":0.0013469856,"about_ca_system_score_codex":0.00023491577,"about_ca_system_score_gemma":0.0002852948,"threshold_uncertainty_score":0.004506111},"labels":[],"label_agreement":null},{"id":"W1999931286","doi":"10.1074/jbc.m408583200","title":"Role of the Tetradecapeptide Repeat Domain of Human Histone Deacetylase 6 in Cytoplasmic Retention","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"HDAC6; HDAC10; Histone deacetylase; Nuclear export signal; Biology; Nuclear localization sequence; Caenorhabditis elegans; Ubiquitin; Cytoplasm; Cell biology; SUMO protein; HDAC11; Acetylation; SAP30; Histone deacetylase 2; Biochemistry; Histone; Cell nucleus; Gene","score_opus":0.014087860148673158,"score_gpt":0.2763500375605277,"score_spread":0.26226217741185454,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999931286","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9902452,0.0049345945,0.0032210941,0.0001128919,0.000028709968,0.000011778615,0.00023036581,0.00005308529,0.0011622637],"genre_scores_gemma":[0.9944185,0.0017549781,0.0019658946,0.00005259863,0.000013311159,0.0000076064252,0.00051994313,0.000007903556,0.001259286],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999374,0.000008014719,0.0000061515834,0.000020312436,0.0000143002835,0.000013700452],"domain_scores_gemma":[0.9999168,0.0000111507325,0.000030166702,0.000013338695,0.0000078731855,0.00002068871],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007909459,0.00021610761,0.00012244798,0.000057035424,0.00013613561,0.00021109148,0.00014549613,0.00021432585,0.000723204],"category_scores_gemma":[0.000089041176,0.00010104415,0.00019683843,0.000066229506,0.0001523995,0.00019651851,0.00017202563,0.00022957672,0.00050732505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000102981765,0.00000981672,0.00057206996,0.000034749897,0.0000046035366,0.00010058363,0.000008318989,0.00005184979,0.9972964,0.00008877667,0.000027118462,0.0017027493],"study_design_scores_gemma":[0.000021305954,0.00021257235,0.009332033,0.0000061106593,0.000021170576,0.00163804,0.00002069912,0.00068758137,0.9842986,0.0000621006,0.003693281,0.0000064222886],"about_ca_topic_score_codex":0.00028254677,"about_ca_topic_score_gemma":0.00032022837,"teacher_disagreement_score":0.000723204,"about_ca_system_score_codex":0.00016531369,"about_ca_system_score_gemma":0.0001410452,"threshold_uncertainty_score":0.0024194121},"labels":[],"label_agreement":null},{"id":"W2000121640","doi":"10.3727/096504010x12704916124828","title":"The Inhibitor of Growth 1 (ING1) Is Involved in Trichostatin A-Induced Apoptosis and Caspase 3 Signaling in p53-Deficient Glioblastoma Cells","year":2009,"lang":"en","type":"article","venue":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Trichostatin A; Cancer research; Apoptosis; Biology; Gene knockdown; Glioma; Histone; Histone deacetylase; Histone deacetylase inhibitor; Death domain; DNA damage; Molecular biology; Programmed cell death; DNA; Genetics","score_opus":0.10661558656995794,"score_gpt":0.45956288902684006,"score_spread":0.3529473024568821,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2000121640","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9884852,0.00564835,0.002220862,0.00022060951,0.000048681228,0.000039325067,0.0010759543,0.00016653622,0.0020944108],"genre_scores_gemma":[0.98875076,0.003492623,0.0015448735,0.0000957378,0.000009764762,0.00003961051,0.0021690947,0.000016798302,0.0038807942],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999323,0.000007048654,0.000005089375,0.000011998286,0.000022267117,0.00002120856],"domain_scores_gemma":[0.9999628,0.0000038365943,0.000014602937,0.0000034479285,0.0000045139404,0.000010694052],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000050423954,0.0003399414,0.0001984705,0.00020880165,0.00014107896,0.00019195057,0.00011647535,0.000141157,0.001253628],"category_scores_gemma":[0.000050577873,0.00009117618,0.00020659239,0.00018793087,0.00012873443,0.00009611176,0.00011833451,0.00037764007,0.00040234788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016478487,0.000025985895,0.0007774746,0.000060772218,0.0000087766275,0.000088011904,0.000009624919,0.00004070384,0.9961176,0.0000598039,0.00013976336,0.0025066629],"study_design_scores_gemma":[0.000029799921,0.0005444986,0.026839357,0.000010712769,0.000056036333,0.0009972731,0.00005414802,0.00081511785,0.95995194,0.000074381496,0.010622577,0.000004233547],"about_ca_topic_score_codex":0.00063661183,"about_ca_topic_score_gemma":0.0011128878,"teacher_disagreement_score":0.001253628,"about_ca_system_score_codex":0.000244322,"about_ca_system_score_gemma":0.00018822713,"threshold_uncertainty_score":0.0041938424},"labels":[],"label_agreement":null},{"id":"W2001176921","doi":"10.1523/jneurosci.5303-08.2009","title":"The Polycomb Group Gene <i>Bmi1</i> Regulates Antioxidant Defenses in Neurons by Repressing <i>p53</i> Pro-Oxidant Activity","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"BMI1; Reactive oxygen species; Biology; Psychological repression; Oxidative stress; Antioxidant; Cell biology; Gene; Genetics; Biochemistry; Gene expression","score_opus":0.014039589771208739,"score_gpt":0.28027208568799844,"score_spread":0.2662324959167897,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2001176921","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9865258,0.0032477835,0.006604433,0.00018766332,0.00004327822,0.00002685036,0.00083425693,0.00030019245,0.0022297904],"genre_scores_gemma":[0.99228716,0.001522326,0.0023848366,0.00005464977,0.000011499533,0.000026222271,0.0006070101,0.00004332038,0.0030629516],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993443,0.0000068957174,0.000005685119,0.00001763493,0.00001870718,0.000016555095],"domain_scores_gemma":[0.99988747,0.000008374548,0.000044785753,0.0000104724695,0.000014116216,0.000034841945],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005713199,0.0002560333,0.00015133228,0.00022254894,0.000143936,0.0002502693,0.00021324022,0.00015202897,0.001422443],"category_scores_gemma":[0.00009620318,0.00011088745,0.00016243395,0.00012432218,0.0002327292,0.00015915059,0.0002685727,0.00043080014,0.0004648587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000029152934,0.0000035891615,0.0003773183,0.000014110901,0.0000023900852,0.000024580648,0.000008252933,0.000019853858,0.9983192,0.00009296859,0.00003061878,0.0010779604],"study_design_scores_gemma":[0.000015783711,0.00012863832,0.052579008,0.000013723461,0.000017146509,0.0004928409,0.000048326303,0.0009094761,0.941079,0.00022556541,0.0044809296,0.000009504685],"about_ca_topic_score_codex":0.0009496477,"about_ca_topic_score_gemma":0.0013305608,"teacher_disagreement_score":0.001422443,"about_ca_system_score_codex":0.00022884244,"about_ca_system_score_gemma":0.00015634688,"threshold_uncertainty_score":0.004758537},"labels":[],"label_agreement":null},{"id":"W2002139658","doi":"10.1093/toxsci/kfs292","title":"Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs","year":2012,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chondrogenesis; Limb bud; Valproic Acid; Histone deacetylase; RUNX2; Teratology; SOX9; Chemistry; Neural tube; Cell biology; Developmental toxicity; Limb development; Endocrinology; Internal medicine; Biology; Embryo; Gene expression; Osteoblast; Biochemistry; In vitro; Histone; Medicine; Mesenchymal stem cell; Neuroscience; Fetus; Gene; Genetics; Pregnancy; Epilepsy","score_opus":0.029270356972801618,"score_gpt":0.30119753131993043,"score_spread":0.2719271743471288,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2002139658","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99486417,0.0022424832,0.0010060926,0.00008181842,0.000025897541,0.000015011263,0.00036956664,0.00005104357,0.0013441043],"genre_scores_gemma":[0.9933164,0.0016256815,0.0009857827,0.000044681838,0.000009379642,0.00003510919,0.0004393459,0.00001911076,0.0035245887],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997961,0.000044765304,0.000025476915,0.000036328845,0.00004667222,0.000050661296],"domain_scores_gemma":[0.99985504,0.000026316638,0.000038045226,0.000017287932,0.000012977434,0.000050337985],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013863745,0.00031862894,0.0002927534,0.000390143,0.00014833946,0.00027528856,0.00018836484,0.00023967841,0.000967425],"category_scores_gemma":[0.00012072409,0.00023732892,0.00027760374,0.00013680852,0.00025043686,0.00012850227,0.00014832689,0.00055425556,0.00025478407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016880214,0.000020693979,0.00019482854,0.000017471004,0.0000046800405,0.000027526197,0.000009750443,0.000029633766,0.9988921,0.000034033033,0.000016163218,0.0005843181],"study_design_scores_gemma":[0.000011401484,0.00043327519,0.0035062658,0.0000041274225,0.000012773808,0.0000749417,0.000019579657,0.0001947306,0.99496055,0.00002587351,0.0007543731,0.0000020165082],"about_ca_topic_score_codex":0.0008969633,"about_ca_topic_score_gemma":0.0018093763,"teacher_disagreement_score":0.000967425,"about_ca_system_score_codex":0.00027761192,"about_ca_system_score_gemma":0.0002952306,"threshold_uncertainty_score":0.0032362938},"labels":[],"label_agreement":null},{"id":"W2002697622","doi":"10.1002/stem.1398","title":"Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene-Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia","year":2013,"lang":"en","type":"article","venue":"Stem Cells","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Biotechnology and Biological Sciences Research Council; Leukaemia and Lymphoma Research; Department of Education and Learning, Northern Ireland","keywords":"Myeloid leukemia; Biology; Leukemia; Cancer research; Oncogene; Myeloid; Ex vivo; In vivo; Immunology; Cell; Cell cycle; Genetics","score_opus":0.010158119844667544,"score_gpt":0.24662911115052188,"score_spread":0.23647099130585433,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2002697622","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9966683,0.00032233738,0.0016140959,0.00007260076,0.000026413683,0.000027187816,0.00042737645,0.00010057494,0.000741235],"genre_scores_gemma":[0.9951232,0.0004569841,0.0017294781,0.0000232773,0.000006221334,0.00004948167,0.00064241636,0.000016872867,0.0019521683],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986696,0.000021446276,0.000012913208,0.000024065188,0.000045895344,0.000028758725],"domain_scores_gemma":[0.9999149,0.000010009961,0.00002826307,0.000011653681,0.000006368668,0.000028918994],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000121784586,0.00039157656,0.00030626674,0.0004584914,0.00016535893,0.00019157374,0.00034259266,0.00019860169,0.0010152938],"category_scores_gemma":[0.00008518527,0.000115021634,0.00024356425,0.00022614568,0.00023889152,0.00015976805,0.00014895078,0.0006226339,0.00016499699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021352881,0.00008174907,0.00010852448,0.000014693705,0.000005341105,0.000032089443,0.000011388784,0.000125393,0.9980532,0.00015425394,0.000041880114,0.0011578925],"study_design_scores_gemma":[0.000027808863,0.0007542753,0.0014252083,0.0000023766847,0.000014399941,0.00010959167,0.000014829652,0.0010696965,0.99547887,0.00004555126,0.0010543404,0.0000031529921],"about_ca_topic_score_codex":0.0009646983,"about_ca_topic_score_gemma":0.0021736326,"teacher_disagreement_score":0.0010152938,"about_ca_system_score_codex":0.00041264665,"about_ca_system_score_gemma":0.0002740768,"threshold_uncertainty_score":0.003396511},"labels":[],"label_agreement":null},{"id":"W2004429137","doi":"10.1093/nar/gkp270","title":"A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Biology; Acetylation; Histone; Biochemistry; Chromatin; Yeast; Catabolism; Lysine; Trichostatin A; Metabolism; Cell biology; Histone deacetylase; DNA; Amino acid; Gene","score_opus":0.02197503032598102,"score_gpt":0.3432736604338122,"score_spread":0.32129863010783116,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004429137","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9975261,0.00072738476,0.0010301822,0.000040162027,0.0000101241885,0.000004635267,0.000113458074,0.000039200975,0.0005087923],"genre_scores_gemma":[0.9982322,0.0002356223,0.00070435315,0.00002548383,0.0000041780645,0.000007403321,0.00026309091,0.000012520508,0.0005150984],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999373,0.00000723587,0.000005815194,0.000017271195,0.000013661791,0.000018643099],"domain_scores_gemma":[0.9999447,0.000007270662,0.000015256866,0.000008093377,0.0000046897817,0.000020027594],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007574973,0.00024786658,0.00020510131,0.000100183155,0.000084684725,0.00022811006,0.00015517579,0.000097617056,0.00054730894],"category_scores_gemma":[0.000081391394,0.00013315196,0.00015948237,0.00011427691,0.00020573847,0.0001224774,0.0002611069,0.00019670484,0.00014691675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010875132,0.000004618324,0.0004972277,0.000014285517,0.00000451748,0.000018161954,0.000006753421,0.00004404981,0.9983725,0.000051506267,0.000012660528,0.0008649727],"study_design_scores_gemma":[0.000009171001,0.00010879751,0.01170127,0.00000301222,0.000010797169,0.000053250395,0.000020909949,0.0010061995,0.98617506,0.000057307007,0.00085086096,0.0000033047038],"about_ca_topic_score_codex":0.0008254573,"about_ca_topic_score_gemma":0.0015280538,"teacher_disagreement_score":0.0008254573,"about_ca_system_score_codex":0.0003565557,"about_ca_system_score_gemma":0.00011667298,"threshold_uncertainty_score":0.0025870204},"labels":[],"label_agreement":null},{"id":"W2004800182","doi":"10.1182/blood-2007-10-115873","title":"Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Leukemia; Pharmacokinetics; Nausea; Internal medicine; Histone deacetylase inhibitor; Gastroenterology; Vomiting; Pharmacology; Oncology; Histone deacetylase; Histone; Chemistry","score_opus":0.02311180398526197,"score_gpt":0.2997366033922694,"score_spread":0.2766247994070074,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004800182","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99174654,0.0031948786,0.0010652618,0.00028809777,0.00008497527,0.0012278722,0.00081642537,0.000171942,0.0014038885],"genre_scores_gemma":[0.98788804,0.0032678822,0.0023976574,0.0006572902,0.000091326794,0.0012980935,0.002299197,0.000033255077,0.0020672379],"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9998708,0.00004221397,0.0000055821565,0.000028019593,0.000018791545,0.00003451449],"domain_scores_gemma":[0.9998361,0.000023279437,0.00003261575,0.000011446696,0.000010704022,0.0000857324],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043882255,0.0008184548,0.0012453918,0.00026566052,0.00027306768,0.00050937955,0.0006462643,0.0007716755,0.00196244],"category_scores_gemma":[0.00030765566,0.00027659055,0.00049458863,0.00030063238,0.0004470972,0.00026318888,0.0002639951,0.0016855306,0.0004357344],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.2728429,0.08125108,0.016090954,0.0012602598,0.0008921274,0.000998162,0.00041407498,0.0086947605,0.26673234,0.0008514347,0.014492331,0.33547965],"study_design_scores_gemma":[0.2892194,0.6224694,0.02510563,0.000089459056,0.0005251106,0.0014110481,0.00008175247,0.0051460085,0.042259645,0.0006038397,0.013038433,0.000050162223],"about_ca_topic_score_codex":0.0012056166,"about_ca_topic_score_gemma":0.002846072,"teacher_disagreement_score":0.00196244,"about_ca_system_score_codex":0.0007015681,"about_ca_system_score_gemma":0.0013530595,"threshold_uncertainty_score":0.0065650344},"labels":[],"label_agreement":null},{"id":"W2005015636","doi":"10.1016/j.bmcl.2008.12.097","title":"Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Histone Acetyltransferases; Acetylation; Quinoline; Histone; Histone acetyltransferase; Enzyme; Biochemistry; In vitro; Western blot; Histone H3; Acetyltransferases; Molecular biology","score_opus":0.010983231273324135,"score_gpt":0.2608450851638985,"score_spread":0.24986185389057436,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2005015636","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9612618,0.016340472,0.011478198,0.00043095424,0.00016729292,0.0004474671,0.001032118,0.00047157507,0.008370109],"genre_scores_gemma":[0.98313636,0.004875432,0.0045198305,0.00016672815,0.00004077573,0.00011854611,0.0016718232,0.000038982835,0.00543153],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986684,0.00002561623,0.000012116902,0.000018764591,0.000037180474,0.000039365612],"domain_scores_gemma":[0.99988663,0.000022864928,0.000024248813,0.000009639736,0.000033123026,0.000023524732],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003284659,0.00043156385,0.0005687036,0.00051450863,0.00018421459,0.00032203223,0.0006813094,0.0003399121,0.0019975852],"category_scores_gemma":[0.0002362092,0.00024187836,0.00041072696,0.00022159696,0.00016812803,0.00020357095,0.00018449198,0.0005710149,0.0005311602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008506125,0.00030180337,0.00049904524,0.0001359853,0.000055286047,0.00024659833,0.000041136816,0.0010228667,0.9811644,0.0005243714,0.0004902227,0.014667729],"study_design_scores_gemma":[0.00071975746,0.0039941217,0.0033342498,0.000028324732,0.0001758841,0.0009630877,0.000042527474,0.0034511592,0.9721715,0.0001985008,0.014888973,0.00003194165],"about_ca_topic_score_codex":0.0012556739,"about_ca_topic_score_gemma":0.0028223607,"teacher_disagreement_score":0.0019975852,"about_ca_system_score_codex":0.0005091046,"about_ca_system_score_gemma":0.00027795252,"threshold_uncertainty_score":0.0066825747},"labels":[],"label_agreement":null},{"id":"W2007462973","doi":"10.1007/s00018-010-0599-9","title":"MYST-family histone acetyltransferases: beyond chromatin","year":2010,"lang":"en","type":"review","venue":"Cellular and Molecular Life Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Histone Acetyltransferases; Chromatin; Histone; Biology; Acetylation; Histone-modifying enzymes; Non-histone protein; Cell biology; Biochemistry; Chromatin remodeling; Genetics; DNA; Gene","score_opus":0.023949090586689068,"score_gpt":0.3303452773294589,"score_spread":0.3063961867427698,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2007462973","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00021025882,0.9969752,0.00076310564,0.00043129598,0.00057074986,0.0000048403103,0.000029348126,0.000021527318,0.0009937101],"genre_scores_gemma":[0.0014687033,0.9949025,0.0008178487,0.00047363795,0.00045850166,0.000014314786,0.00009574727,0.000004014403,0.0017647666],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99984574,0.000015247096,0.000020683021,0.000035430887,0.00006134,0.000021401036],"domain_scores_gemma":[0.99983287,0.000054043147,0.000028311277,0.00001070893,0.00004284765,0.000031201147],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007787139,0.0012526165,0.0016759806,0.0010311871,0.00028409238,0.0010502397,0.001425131,0.0013893255,0.0021626626],"category_scores_gemma":[0.0005245378,0.0004174668,0.00033821634,0.0016406783,0.0008666806,0.0021964586,0.00087264774,0.0023684292,0.0027236897],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016086827,0.000046696325,0.00019115808,0.005018227,0.00008203772,0.00027472447,0.00003828251,0.00041939688,0.008445603,0.006980509,0.04198347,0.9363591],"study_design_scores_gemma":[0.00002629933,0.000043577118,0.00031749153,0.0002706788,0.000050240636,0.00081382075,0.000025319574,0.00010413548,0.0019284136,0.0019396998,0.994467,0.000013328106],"about_ca_topic_score_codex":0.00052331557,"about_ca_topic_score_gemma":0.0013899674,"teacher_disagreement_score":0.0021626626,"about_ca_system_score_codex":0.0008516261,"about_ca_system_score_gemma":0.00096365984,"threshold_uncertainty_score":0.007234812},"labels":[],"label_agreement":null},{"id":"W2008195380","doi":"10.1016/s1063-4584(10)60257-9","title":"230 VALPROIC ACID SUPPRESSES INTERLEUKIN-1β-INDUCED MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 EXPRESSION IN CHONDROCYTES","year":2010,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Prostaglandin E2; Valproic Acid; Chemistry; Microsome; Interleukin 1β; Interleukin; Internal medicine; Endocrinology; Pharmacology; Medicine; Biochemistry; Biology; Enzyme; Cytokine; Neuroscience; Epilepsy","score_opus":0.006419204405751235,"score_gpt":0.24339733842908773,"score_spread":0.2369781340233365,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2008195380","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99557143,0.002179923,0.00058006094,0.00020138307,0.000103508224,0.00001998093,0.00039924,0.0000875883,0.0008568233],"genre_scores_gemma":[0.99491066,0.0010469987,0.0005765477,0.00010814544,0.00003777479,0.000031187887,0.00061997987,0.000018652978,0.0026500374],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997538,0.000047387788,0.000039550276,0.000031110645,0.00004641099,0.00008177044],"domain_scores_gemma":[0.99982303,0.000028144283,0.000038976923,0.00002109663,0.000020315576,0.00006853383],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015390878,0.00052275223,0.00052248,0.00033701048,0.00035580187,0.000508549,0.0002803812,0.00037393265,0.0018464072],"category_scores_gemma":[0.00022435068,0.0002939605,0.00039556198,0.000251624,0.0005335802,0.00023627971,0.0002739099,0.0007879283,0.0006577828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0060820254,0.00019829297,0.0003661074,0.00009119549,0.000030092016,0.00016824332,0.000039411898,0.000077359415,0.9904789,0.000095835916,0.00014912883,0.0022235191],"study_design_scores_gemma":[0.0004960516,0.0030766446,0.0046267062,0.000011535272,0.000061981526,0.00043091297,0.00015178346,0.000565904,0.9881074,0.00010387767,0.002352925,0.000014336887],"about_ca_topic_score_codex":0.0022213429,"about_ca_topic_score_gemma":0.002631072,"teacher_disagreement_score":0.0022213429,"about_ca_system_score_codex":0.00033752606,"about_ca_system_score_gemma":0.00069876324,"threshold_uncertainty_score":0.0061768293},"labels":[],"label_agreement":null},{"id":"W2009008561","doi":"10.1016/j.jaci.2007.09.004","title":"Epigenetic regulation of established human type 1 versus type 2 cytokine responses","year":2007,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"","keywords":"Trichostatin A; Epigenetics; Cytokine; Immunology; Histone deacetylase; Biology; Interleukin 4; Histone; Genetics; Gene","score_opus":0.03913323993661125,"score_gpt":0.3793068373052174,"score_spread":0.3401735973686062,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2009008561","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98624957,0.007208395,0.001772636,0.00021594652,0.0001236779,0.000023311062,0.00043227235,0.00004227461,0.003931949],"genre_scores_gemma":[0.9938694,0.0019503074,0.00045780197,0.000088705056,0.000051439256,0.000019718069,0.00042988535,0.000011717852,0.0031210661],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984527,0.000030812742,0.000007473251,0.000034727724,0.000027919974,0.000053775137],"domain_scores_gemma":[0.9998789,0.000030229952,0.000029299566,0.000018403593,0.000019540143,0.00002363627],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020045582,0.00013796134,0.00019621819,0.00015738163,0.00016290128,0.00048854563,0.00015947415,0.00014542179,0.0030802696],"category_scores_gemma":[0.00023461269,0.00009301741,0.00014439721,0.00011125889,0.00016739829,0.00018701529,0.00022584015,0.00040065518,0.00035872398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008023776,0.00005527402,0.004197794,0.000058575246,0.000018083108,0.000121322926,0.000114579154,0.000057510482,0.9825895,0.001047225,0.0002688086,0.010668984],"study_design_scores_gemma":[0.00010599273,0.000888413,0.17916353,0.00005394068,0.00009594385,0.0010031809,0.00042561148,0.00058194576,0.79853857,0.00079223467,0.018333126,0.000017450277],"about_ca_topic_score_codex":0.00028731255,"about_ca_topic_score_gemma":0.0010193756,"teacher_disagreement_score":0.0030802696,"about_ca_system_score_codex":0.0003120301,"about_ca_system_score_gemma":0.00019042348,"threshold_uncertainty_score":0.01030457},"labels":[],"label_agreement":null},{"id":"W2009497825","doi":"10.1038/bjc.2011.13","title":"Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours","year":2011,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University; University of Toronto; Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Pharmacokinetics; Pharmacodynamics; Histone deacetylase inhibitor; Histone deacetylase; Medicine; Pharmacology; Internal medicine; Histone; Chemistry; Biochemistry","score_opus":0.023074027725210004,"score_gpt":0.392730181775085,"score_spread":0.369656154049875,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2009497825","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9918161,0.0026325698,0.0010146456,0.0003032182,0.000053168184,0.0015144177,0.0011029313,0.000100357414,0.001462584],"genre_scores_gemma":[0.9909995,0.0016899334,0.0019809545,0.00035280132,0.000064916,0.001188446,0.0019200336,0.000027427197,0.0017759465],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99972063,0.000104383835,0.00001721646,0.00005655336,0.000048535447,0.00005274722],"domain_scores_gemma":[0.9995467,0.000057809277,0.00012761274,0.000039528437,0.000042045594,0.00018622572],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074298953,0.00115279,0.0015476857,0.00032774112,0.00039453027,0.00057167764,0.00053099444,0.0006341608,0.0024111564],"category_scores_gemma":[0.0005472463,0.0004316978,0.00070199376,0.0004493664,0.00065337983,0.00045969617,0.00028111888,0.0023169774,0.0007730924],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.33449337,0.083087906,0.01962218,0.0013255161,0.0015829696,0.00081167853,0.0006556414,0.009019801,0.3302326,0.00036846957,0.0071225436,0.21167734],"study_design_scores_gemma":[0.113024406,0.8196191,0.036903158,0.000048514943,0.00054990785,0.0009334161,0.00008237706,0.0022077258,0.019800898,0.00021088426,0.0065787244,0.0000409948],"about_ca_topic_score_codex":0.0008298213,"about_ca_topic_score_gemma":0.0017503193,"teacher_disagreement_score":0.0024111564,"about_ca_system_score_codex":0.00080261304,"about_ca_system_score_gemma":0.001278875,"threshold_uncertainty_score":0.008066118},"labels":[],"label_agreement":null},{"id":"W2010110230","doi":"10.1038/nchembio.301","title":"Carbon metabolism–mediated myogenic differentiation","year":2010,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Howard Hughes Medical Institute","keywords":"C2C12; Cell biology; Cellular differentiation; Biochemistry; Pentose phosphate pathway; Myocyte; Enzyme; Gene knockdown; Biology; Metabolism; Chemistry; Myogenesis; Glycolysis; Gene","score_opus":0.003457628608623163,"score_gpt":0.26220042425877577,"score_spread":0.2587427956501526,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010110230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8657228,0.025970312,0.030362064,0.002339997,0.0012647256,0.00033169563,0.00391377,0.00067316694,0.069421396],"genre_scores_gemma":[0.9521993,0.0058964235,0.008102732,0.0003768368,0.00006644214,0.000092360206,0.001180147,0.0000896924,0.031996187],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999848,0.000020377985,0.000013901005,0.000033067652,0.000045992445,0.00003854683],"domain_scores_gemma":[0.9998995,0.00002190561,0.000017187778,0.000017259179,0.000014026262,0.000030094458],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021845086,0.0004811452,0.00017622701,0.00046378045,0.0002605762,0.0004214875,0.00038017653,0.00040764286,0.0029669872],"category_scores_gemma":[0.00010045531,0.00023506678,0.00030588126,0.00030129062,0.000335904,0.00025487834,0.0005099295,0.0009311781,0.0007262629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019942314,0.000024257135,0.00007951857,0.00007763445,0.000007625091,0.00006458941,0.000011373115,0.0001084495,0.992516,0.0014098645,0.00023222169,0.005269161],"study_design_scores_gemma":[0.000020679017,0.00007717363,0.0015866656,0.00001152017,0.000008730523,0.00007264297,0.000011649965,0.00028995544,0.9905778,0.00014122544,0.007197876,0.0000041053913],"about_ca_topic_score_codex":0.0015465519,"about_ca_topic_score_gemma":0.0037179107,"teacher_disagreement_score":0.0029669872,"about_ca_system_score_codex":0.00070921064,"about_ca_system_score_gemma":0.0005026449,"threshold_uncertainty_score":0.009925604},"labels":[],"label_agreement":null},{"id":"W2010457667","doi":"10.1038/cddis.2010.21","title":"Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2","year":2010,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute for Biological Sciences","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Cell biology; Biology; HDAC1; Apoptosis; Signal transduction; Histone deacetylase 2; RNA interference; Downregulation and upregulation; ASK1; Transforming growth factor; Cancer research; Kinase; Histone deacetylase; Histone; Protein kinase A; Mitogen-activated protein kinase kinase; Biochemistry; RNA","score_opus":0.004855283115962289,"score_gpt":0.23201512802671037,"score_spread":0.2271598449107481,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010457667","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9850712,0.0074089463,0.0031856957,0.00023678041,0.00013586838,0.000035317425,0.00041223862,0.00009789238,0.0034161054],"genre_scores_gemma":[0.99031395,0.0026562507,0.001314179,0.0001517794,0.00004284586,0.00004990697,0.0005688586,0.000024594972,0.0048774877],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997863,0.0000205827,0.000016653745,0.000054025946,0.00005322001,0.000069130685],"domain_scores_gemma":[0.9999379,0.000005948618,0.00002102927,0.0000066214584,0.000011197654,0.00001740761],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015049822,0.00036198203,0.00036922548,0.00020390119,0.00017029163,0.00044532094,0.00021353726,0.0002461453,0.0014993665],"category_scores_gemma":[0.000119082615,0.00021650731,0.00042510987,0.0001490049,0.00019141269,0.000267859,0.00019856513,0.00053476164,0.0003815308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00033650588,0.00003315823,0.0007033124,0.000058166097,0.000017804961,0.00005830872,0.000015372907,0.0000800434,0.9954983,0.0002595539,0.0001125758,0.0028268038],"study_design_scores_gemma":[0.000120237,0.000393936,0.022726506,0.000012707911,0.000096697855,0.0005586319,0.00006881924,0.0014838249,0.96572447,0.00019900141,0.008600605,0.000014577544],"about_ca_topic_score_codex":0.0003257096,"about_ca_topic_score_gemma":0.00073282875,"teacher_disagreement_score":0.0014993665,"about_ca_system_score_codex":0.00032835474,"about_ca_system_score_gemma":0.000204892,"threshold_uncertainty_score":0.00501585},"labels":[],"label_agreement":null},{"id":"W2012986709","doi":"10.1016/j.biopha.2011.06.007","title":"HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation","year":2011,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"MCF-7; Apoptosis; Cell growth; Cancer research; Benzamide; Histone deacetylase; Histone deacetylase inhibitor; Cancer cell; Cell cycle checkpoint; Cell cycle; Breast cancer; Chemistry; Biology; Molecular biology; Cancer; Internal medicine; Medicine; Histone; Biochemistry; Gene; Human breast","score_opus":0.02302224091693545,"score_gpt":0.31308678457781575,"score_spread":0.2900645436608803,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012986709","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9909065,0.0023860114,0.0007198757,0.0004926098,0.00018986421,0.000029567636,0.0010193726,0.0002540463,0.0040021976],"genre_scores_gemma":[0.98876953,0.002369374,0.00077607913,0.0001296567,0.000039669707,0.000030932653,0.0015845782,0.000018510233,0.006281546],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988604,0.000015378118,0.00000788029,0.000012696929,0.000023137438,0.0000549243],"domain_scores_gemma":[0.9999392,0.000013960146,0.000009002627,0.000009823108,0.0000070950086,0.000020819887],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013201643,0.0004290522,0.0002846919,0.000441078,0.00030949403,0.00020728298,0.0002749932,0.00028416282,0.0040112743],"category_scores_gemma":[0.000121996825,0.00017667167,0.00028979508,0.00029538543,0.0002421146,0.0001518803,0.00016889318,0.00086904236,0.0009205925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018650581,0.00055529666,0.00052461587,0.00007971066,0.000013255925,0.00012369754,0.000022715976,0.00018219957,0.98809516,0.00021074996,0.00072873366,0.0075986898],"study_design_scores_gemma":[0.00010405645,0.0017311191,0.0035298646,0.000006859427,0.000023452001,0.00021398965,0.000058504414,0.00048738133,0.9896571,0.00006232576,0.004118263,0.0000069528237],"about_ca_topic_score_codex":0.0028418193,"about_ca_topic_score_gemma":0.0051281573,"teacher_disagreement_score":0.0040112743,"about_ca_system_score_codex":0.00042071313,"about_ca_system_score_gemma":0.00057918456,"threshold_uncertainty_score":0.013419032},"labels":[],"label_agreement":null},{"id":"W2013547494","doi":"10.1074/jbc.m707362200","title":"Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":258,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute; Wellcome Trust","keywords":"Histone deacetylase; HDAC11; Histone deacetylase 2; Active site; Histone deacetylase 5; Binding site; Chemistry; Histone; Biochemistry; Biology; Cell biology; Enzyme; Gene","score_opus":0.04104490758608786,"score_gpt":0.30037311258810023,"score_spread":0.25932820500201237,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013547494","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.966229,0.0109071,0.01397574,0.00044078522,0.00017113876,0.000054931388,0.0020876983,0.00031799445,0.005815491],"genre_scores_gemma":[0.98046356,0.0020105506,0.007822976,0.00020828667,0.0000458849,0.000028748726,0.005232213,0.000030175106,0.00415752],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989355,0.000012585834,0.0000069982943,0.000022439415,0.000042350584,0.000022047281],"domain_scores_gemma":[0.99990034,0.000013868153,0.00002292511,0.000014279067,0.000021455664,0.000027112364],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008902692,0.00037380419,0.00033495965,0.0001734644,0.00026140083,0.00036688376,0.00033637462,0.00034074025,0.0015116803],"category_scores_gemma":[0.0001268669,0.00015590191,0.0004328889,0.00025568297,0.00024441286,0.00017405921,0.00022659074,0.00038985538,0.0011566035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023600605,0.00005974131,0.0046019936,0.00016575528,0.00008382814,0.00036865645,0.000029923105,0.0005013751,0.9773662,0.001003977,0.000895432,0.014687031],"study_design_scores_gemma":[0.000051465016,0.00033855566,0.019920245,0.000015385105,0.00009793952,0.0027800575,0.00007031,0.0047826483,0.9171816,0.00034735294,0.05438565,0.000028733595],"about_ca_topic_score_codex":0.001085332,"about_ca_topic_score_gemma":0.001239365,"teacher_disagreement_score":0.0015116803,"about_ca_system_score_codex":0.00039489302,"about_ca_system_score_gemma":0.0002946196,"threshold_uncertainty_score":0.0050570965},"labels":[],"label_agreement":null},{"id":"W2013719793","doi":"10.1371/journal.pone.0060943","title":"Src Regulates the Activity of the ING1 Tumor Suppressor","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Fondation pour la Recherche Médicale; Alberta Cancer Foundation","keywords":"Proto-oncogene tyrosine-protein kinase Src; Chromatin; Biology; Cell biology; Histone deacetylase; Epigenetics; Cancer research; Carcinogenesis; Tyrosine kinase; Regulator; Histone; Kinase; Signal transduction; Genetics; Cancer; DNA; Gene","score_opus":0.021891205645539143,"score_gpt":0.2308883915602928,"score_spread":0.20899718591475366,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013719793","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98824626,0.0046511623,0.0025659201,0.00016947149,0.000040288534,0.000011222901,0.00022843778,0.0001072101,0.0039798887],"genre_scores_gemma":[0.99503493,0.0015474678,0.0005394619,0.000021827267,0.000009965679,0.0000059619524,0.00025797178,0.0000152535895,0.0025671623],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999229,0.000010191306,0.0000035531668,0.00001684077,0.000019820394,0.000026722173],"domain_scores_gemma":[0.9999325,0.000009130133,0.000024598448,0.0000063026428,0.0000120124405,0.000015396414],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008059172,0.00024798763,0.00014673598,0.0001777792,0.00015862683,0.000268944,0.00013665414,0.00012682963,0.0011714548],"category_scores_gemma":[0.00011996843,0.00009826006,0.00012814252,0.00011320501,0.00018717226,0.000105588544,0.00019878297,0.00027451303,0.00038877333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009536189,0.00001305858,0.0007481397,0.000025454086,0.0000037657805,0.000065608176,0.000015298363,0.00006960569,0.99513865,0.0002731209,0.000115511415,0.003436325],"study_design_scores_gemma":[0.000013098177,0.00014181773,0.02149614,0.0000044407243,0.000019668227,0.0003949832,0.000041343796,0.001451715,0.9698942,0.0001855406,0.0063530784,0.000004101832],"about_ca_topic_score_codex":0.00065851636,"about_ca_topic_score_gemma":0.0008920969,"teacher_disagreement_score":0.0011714548,"about_ca_system_score_codex":0.00033659898,"about_ca_system_score_gemma":0.0001676462,"threshold_uncertainty_score":0.003918886},"labels":[],"label_agreement":null},{"id":"W2014204123","doi":"10.1074/jbc.m109.004200","title":"Ubiquitin Ligase Cullin 7 Induces Epithelial-Mesenchymal Transition in Human Choriocarcinoma Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"National Key Research and Development Program of China; Ministry of Science and Technology of the People's Republic of China; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Cullin; Ubiquitin ligase; Ubiquitin; Epithelial–mesenchymal transition; Choriocarcinoma; Cell biology; Chemistry; Transition (genetics); Cancer research; Biology; Molecular biology; Biochemistry; Genetics; Gene","score_opus":0.01626918720770516,"score_gpt":0.28039023188580475,"score_spread":0.2641210446780996,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2014204123","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99127066,0.002010666,0.0019505773,0.00014719952,0.000057118716,0.00011767183,0.00085692585,0.00022096529,0.003368297],"genre_scores_gemma":[0.99178666,0.0009779083,0.001848077,0.00008401183,0.000010217007,0.00009082883,0.0015985129,0.00002917819,0.0035745725],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99971837,0.00004187277,0.000035263198,0.000048698028,0.0000747771,0.00008107368],"domain_scores_gemma":[0.99981886,0.000051735486,0.000025322517,0.000036412854,0.00002256798,0.000045174136],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001900654,0.0003450293,0.0002904919,0.000476373,0.00023335512,0.0003638701,0.00021491438,0.00029317487,0.0012341576],"category_scores_gemma":[0.0001870383,0.00021925884,0.00033106076,0.00031776377,0.0002237498,0.00014450355,0.00025057708,0.0006328995,0.00046994735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000120467725,0.000049098784,0.00018874333,0.000038009443,0.000009756589,0.00015144519,0.000040671337,0.0000638479,0.9984395,0.00011376607,0.000104844,0.000679932],"study_design_scores_gemma":[0.00003079419,0.00025750088,0.0029423726,0.0000054113325,0.000013990211,0.00025095462,0.0000384822,0.00095011893,0.9923741,0.00003179301,0.0031003833,0.0000041311623],"about_ca_topic_score_codex":0.0030104737,"about_ca_topic_score_gemma":0.003316441,"teacher_disagreement_score":0.0030104737,"about_ca_system_score_codex":0.0005143645,"about_ca_system_score_gemma":0.00039565683,"threshold_uncertainty_score":0.0059859157},"labels":[],"label_agreement":null},{"id":"W2014989420","doi":"10.1074/jbc.m112.445668","title":"Dephosphorylation at a Conserved SP Motif Governs cAMP Sensitivity and Nuclear Localization of Class IIa Histone Deacetylases*","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Dephosphorylation; Nuclear transport; Nuclear localization sequence; HDAC4; Nuclear export signal; Biology; Histone deacetylase 5; Histone deacetylase; Cell biology; Histone; Nuclear protein; NLS; Biochemistry; Cell nucleus; Transcription factor; Gene; Phosphatase; Cytoplasm","score_opus":0.01300364777359536,"score_gpt":0.24981155691495985,"score_spread":0.2368079091413645,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2014989420","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99556893,0.0014325469,0.0011249327,0.00006809355,0.000020319896,0.000011987357,0.00012495508,0.000021683249,0.0016266945],"genre_scores_gemma":[0.99810034,0.0004680373,0.0005649895,0.00002306242,0.000007724567,0.000009821252,0.00013898622,0.0000071958325,0.00067978655],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998764,0.000016887785,0.000010759455,0.000028092154,0.000025870771,0.000041988562],"domain_scores_gemma":[0.9998839,0.000031164138,0.00003050645,0.00001557015,0.000010277343,0.000028551469],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012640742,0.0001733609,0.00015232644,0.00013638468,0.00014435247,0.00027437173,0.00016580273,0.00017205582,0.0011863856],"category_scores_gemma":[0.00017874414,0.00014863425,0.00016588434,0.00008548692,0.00028437693,0.00013318307,0.0001950648,0.0003589229,0.0003093775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008426081,0.000007483973,0.00025746066,0.00001411035,0.000002753305,0.000025501055,0.0000045345346,0.0000280685,0.9989145,0.00005937547,0.000010420336,0.00059151946],"study_design_scores_gemma":[0.000009655384,0.00011707649,0.010176129,0.0000042678507,0.000009061195,0.00017577458,0.000024233594,0.0005572127,0.9880894,0.00007116736,0.0007626487,0.0000033322863],"about_ca_topic_score_codex":0.00078147737,"about_ca_topic_score_gemma":0.0015750305,"teacher_disagreement_score":0.0011863856,"about_ca_system_score_codex":0.0003413489,"about_ca_system_score_gemma":0.00015663994,"threshold_uncertainty_score":0.003968835},"labels":[],"label_agreement":null},{"id":"W2016059067","doi":"10.1210/en.2007-0578","title":"Acetylation of Histone H3 and Adrenergic-Regulated Gene Transcription in Rat Pinealocytes","year":2007,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Molecular biology; Trichostatin A; Histone H3; Histone deacetylase; Histone deacetylase inhibitor; Biology; Chromatin immunoprecipitation; HDAC1; Histone; Histone deacetylase 5; Repressor; Promoter; Gene expression; Chemistry; Gene; Biochemistry","score_opus":0.01122024856695489,"score_gpt":0.3032135841505277,"score_spread":0.29199333558357277,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016059067","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98666316,0.009670557,0.0020720197,0.000049135637,0.000029351031,0.000014730882,0.00038160695,0.000027140453,0.0010921739],"genre_scores_gemma":[0.99122685,0.004315003,0.0016834365,0.000052160798,0.000022549437,0.000025513824,0.00069207384,0.000010095258,0.0019723116],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994683,0.000005969715,0.0000035011842,0.000014951905,0.000013529425,0.000015368292],"domain_scores_gemma":[0.9999516,0.000007068952,0.000011983354,0.0000054896664,0.000009675916,0.000014131455],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006887818,0.0001985911,0.00016265154,0.0001924839,0.00012864044,0.00014209273,0.00009986535,0.0001232101,0.0006275187],"category_scores_gemma":[0.000060403898,0.00010055576,0.00021125538,0.00014790276,0.00012912687,0.00010704791,0.00009212768,0.00023285304,0.00021087319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007791685,0.0000049286537,0.00035973688,0.000020929298,0.000003748292,0.000035241294,0.000011398796,0.0000072188786,0.9989297,0.000013869112,0.0000046323694,0.00053073664],"study_design_scores_gemma":[0.000018841403,0.0005914209,0.06470687,0.000010181949,0.000041442298,0.00036632354,0.00009513779,0.00027253834,0.93170077,0.00007057624,0.0021174254,0.0000083982695],"about_ca_topic_score_codex":0.0014107171,"about_ca_topic_score_gemma":0.0024496452,"teacher_disagreement_score":0.0014107171,"about_ca_system_score_codex":0.0001458876,"about_ca_system_score_gemma":0.00013988714,"threshold_uncertainty_score":0.0028049946},"labels":[],"label_agreement":null},{"id":"W2016100326","doi":"10.1084/jem.20121484","title":"Notch pathway activation targets AML-initiating cell homeostasis and differentiation","year":2013,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Irma T. Hirschl Trust; York University; Howard Hughes Medical Institute","keywords":"Notch signaling pathway; Cancer research; Cyclin-dependent kinase 8; Myeloid leukemia; Biology; Hes3 signaling axis; Myeloid; Leukemia; Signal transduction; Notch proteins; Cellular differentiation; Cell biology; Immunology; Genetics; Gene","score_opus":0.013451130640987635,"score_gpt":0.27550230710783863,"score_spread":0.262051176466851,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016100326","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94422805,0.010297367,0.012024459,0.0006563739,0.00023801901,0.00021318639,0.0016033337,0.000647659,0.030091465],"genre_scores_gemma":[0.98262537,0.002921871,0.002730177,0.00013042198,0.000026350926,0.000039906252,0.00092979555,0.000033315646,0.010562801],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988425,0.0000100205425,0.0000085134525,0.000020445787,0.000048951748,0.000027855209],"domain_scores_gemma":[0.99996173,0.000003679795,0.0000070501596,0.0000046971622,0.0000064315905,0.000016412885],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008611242,0.00020610937,0.00017855335,0.00023219814,0.00018007711,0.00040363736,0.00020349545,0.0001808604,0.0027725934],"category_scores_gemma":[0.00006698874,0.00008639249,0.00012609249,0.00013501453,0.0001161466,0.00012908771,0.00023579654,0.0005255034,0.0008971897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010065463,0.000030356496,0.00019960527,0.000034503617,0.0000037201767,0.000053058517,0.0000131955,0.00009993745,0.9921708,0.00109543,0.0002970323,0.005901714],"study_design_scores_gemma":[0.000018017156,0.00007588269,0.0012201689,0.000004504954,0.000009145648,0.00016823385,0.000013521226,0.0005988609,0.9790814,0.00016187767,0.018646594,0.0000018222156],"about_ca_topic_score_codex":0.00048709926,"about_ca_topic_score_gemma":0.0010223176,"teacher_disagreement_score":0.0027725934,"about_ca_system_score_codex":0.0004869846,"about_ca_system_score_gemma":0.00029010884,"threshold_uncertainty_score":0.009275258},"labels":[],"label_agreement":null},{"id":"W2016806028","doi":"10.1038/sj.onc.1209819","title":"Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter","year":2006,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"RHOB; Farnesyltransferase; Biology; Acetylation; HDAC1; Histone; Downregulation and upregulation; Cancer research; Genetics; Gene; Histone deacetylase; Biochemistry; Enzyme; Prenylation","score_opus":0.0030129060989366207,"score_gpt":0.225706606686526,"score_spread":0.2226937005875894,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016806028","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9889009,0.0038275141,0.0024751772,0.00043461967,0.000116260235,0.000028351156,0.0003779747,0.00020356163,0.0036355539],"genre_scores_gemma":[0.9900502,0.0011991328,0.0011789538,0.00009437325,0.000034420216,0.000041795927,0.00067063834,0.000059516835,0.006671077],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99971896,0.000031018495,0.000014913383,0.000035673547,0.00006239278,0.0001370319],"domain_scores_gemma":[0.9998567,0.000025577498,0.000034531946,0.000022767112,0.000010260845,0.00005007444],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015153675,0.0003892391,0.00045020893,0.00032165786,0.00026485225,0.00042086418,0.0002963075,0.000247153,0.002435436],"category_scores_gemma":[0.0001569397,0.0003231372,0.0005180913,0.00018231514,0.00038831015,0.00031412754,0.00027405095,0.0011752526,0.00051296566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046367254,0.00006540879,0.000103247905,0.000023224455,0.000010762906,0.00003154513,0.000013533881,0.00004029342,0.99744797,0.00018005208,0.00010726484,0.001512932],"study_design_scores_gemma":[0.000053962693,0.00025154103,0.003774196,0.0000022822248,0.000015323412,0.00008891109,0.00003099807,0.00032225254,0.99334514,0.000050736544,0.0020609319,0.0000037927775],"about_ca_topic_score_codex":0.0010161366,"about_ca_topic_score_gemma":0.0037699798,"teacher_disagreement_score":0.002435436,"about_ca_system_score_codex":0.00056304707,"about_ca_system_score_gemma":0.0003160808,"threshold_uncertainty_score":0.008147359},"labels":[],"label_agreement":null},{"id":"W2017583298","doi":"10.1016/j.ejca.2010.02.047","title":"Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours","year":2010,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Ovarian cancer; Internal medicine; Chemotherapy; Oncology; Gastroenterology; Peripheral blood mononuclear cell; Toxicity; Histone deacetylase inhibitor; Cancer; Histone deacetylase; Histone; Biology; In vitro","score_opus":0.008189622384496985,"score_gpt":0.2791037541101149,"score_spread":0.2709141317256179,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2017583298","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98977166,0.002998977,0.00054576906,0.0014626256,0.00029731836,0.0013980303,0.0010923279,0.00012707147,0.0023062178],"genre_scores_gemma":[0.9890583,0.0021978694,0.0006896516,0.0008249626,0.00015451499,0.0013317878,0.0019060168,0.00003561217,0.0038012117],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9997985,0.00008021218,0.000008903808,0.00004104244,0.000013434569,0.00005788364],"domain_scores_gemma":[0.9994215,0.00012280788,0.000069305366,0.00004285351,0.000019372725,0.0003241227],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007472802,0.001119902,0.0018300122,0.00042891112,0.00044912338,0.00076299015,0.0006094719,0.0011942971,0.0066375593],"category_scores_gemma":[0.0010385123,0.0006545609,0.00095977564,0.00044260817,0.00093225704,0.0008772346,0.00039260206,0.002515338,0.0009985917],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.9021355,0.015733993,0.003992855,0.00046384815,0.00067446777,0.00017611969,0.00019407654,0.0015279,0.0143671725,0.0002584051,0.0023644874,0.058111146],"study_design_scores_gemma":[0.71339506,0.26784503,0.011582178,0.000026331121,0.00041556734,0.00022868381,0.00013806236,0.0011257264,0.0018238368,0.00035313066,0.0030418609,0.000024491444],"about_ca_topic_score_codex":0.0019115382,"about_ca_topic_score_gemma":0.0041940548,"teacher_disagreement_score":0.0066375593,"about_ca_system_score_codex":0.0009030199,"about_ca_system_score_gemma":0.0011021496,"threshold_uncertainty_score":0.022204876},"labels":[],"label_agreement":null},{"id":"W2018314000","doi":"10.1073/pnas.0607378104","title":"Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Acetylation; Ccaat-enhancer-binding proteins; PCAF; P300-CBP Transcription Factors; HDAC1; Transcription factor; Molecular biology; Lysine; Bromodomain; Chemistry; Biology; Histone; HDAC4; Cell biology; Biochemistry; Nuclear protein; Histone deacetylase; Gene; Amino acid; Histone Acetyltransferases","score_opus":0.02691102036720624,"score_gpt":0.3290427533838895,"score_spread":0.3021317330166833,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2018314000","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99133354,0.0031482868,0.0016197285,0.00010473553,0.000029082203,0.000025635185,0.00026833065,0.00006116533,0.0034095503],"genre_scores_gemma":[0.9922978,0.0018170347,0.0015678435,0.00006736195,0.000007950195,0.000019233414,0.00063879456,0.000017210163,0.0035668232],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999404,0.000005945479,0.0000029327716,0.000013883952,0.000020246394,0.000016482949],"domain_scores_gemma":[0.9999634,0.000002956837,0.0000071189775,0.000005030536,0.0000050086546,0.000016464413],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006905536,0.00024699915,0.00014255496,0.000111428446,0.000114454895,0.00015827888,0.00011563583,0.00006880722,0.00091498106],"category_scores_gemma":[0.00005918822,0.000120459845,0.00014161551,0.000069489564,0.00016181282,0.00006296499,0.0001263779,0.0002331294,0.00033122083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005105018,0.0000030608353,0.00012101758,0.0000105978015,0.0000014986564,0.000014711008,0.0000049368555,0.000013847009,0.99918836,0.000025491678,0.000013477956,0.0005517457],"study_design_scores_gemma":[0.000021577138,0.000099488425,0.019552069,0.000009219081,0.000007862654,0.00014959672,0.000025826472,0.00042039464,0.9752612,0.000036995236,0.0044119903,0.0000036160602],"about_ca_topic_score_codex":0.002999227,"about_ca_topic_score_gemma":0.007307965,"teacher_disagreement_score":0.002999227,"about_ca_system_score_codex":0.0005171832,"about_ca_system_score_gemma":0.00025248626,"threshold_uncertainty_score":0.0059635043},"labels":[],"label_agreement":null},{"id":"W2018508414","doi":"10.1016/s1470-2045(11)70265-0","title":"Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial","year":2011,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada); Royal Victoria Hospital; Princess Margaret Cancer Centre","funders":"National Center for Research Resources; National Institutes of Health; National Cancer Institute; Celgene","keywords":"Medicine; Internal medicine; Adverse effect; Neutropenia; Cohort; Population; Lymphoma; Refractory (planetary science); Surgery; Gastroenterology; Toxicity","score_opus":0.21118876763172023,"score_gpt":0.4264847079896755,"score_spread":0.2152959403579553,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2018508414","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9881813,0.0056649055,0.0006304225,0.00088919594,0.00037955472,0.0011558249,0.0010463604,0.00016632664,0.0018860595],"genre_scores_gemma":[0.98586607,0.004319644,0.0014588924,0.0014127474,0.00023517938,0.0014498334,0.0014746942,0.00003443352,0.0037484325],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9997341,0.00011216784,0.000010032797,0.000045966335,0.00002006218,0.00007767758],"domain_scores_gemma":[0.9995353,0.000107319174,0.000058631955,0.0000423472,0.000019370886,0.0002370196],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010619067,0.0015475573,0.0029022484,0.00036335707,0.00030545288,0.0009586324,0.0007594111,0.0011834556,0.0049182475],"category_scores_gemma":[0.00074525946,0.0005004701,0.0012507365,0.0003964325,0.0009953011,0.001211322,0.00030111198,0.0028962812,0.0009793418],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.90978736,0.007534442,0.001510152,0.0009186737,0.0014790876,0.00014774347,0.000121984245,0.0012784839,0.0069353203,0.00031252424,0.002548162,0.067426056],"study_design_scores_gemma":[0.9279597,0.065929405,0.0028528534,0.000039924667,0.0003667775,0.00012361063,0.000044389923,0.0006406646,0.0005365884,0.0003396093,0.0011455929,0.000020779202],"about_ca_topic_score_codex":0.000837512,"about_ca_topic_score_gemma":0.0032678607,"teacher_disagreement_score":0.0049182475,"about_ca_system_score_codex":0.0007559716,"about_ca_system_score_gemma":0.00082431285,"threshold_uncertainty_score":0.016453207},"labels":[],"label_agreement":null},{"id":"W2018902367","doi":"10.1155/2014/218763","title":"The Beneficial Effects of Valproic Acid in Thyroid Cancer Are Mediated through Promoting Redifferentiation and Reducing Stemness Level: An<i>In Vitro</i>Study","year":2014,"lang":"en","type":"article","venue":"Journal of Thyroid Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Tehran University of Medical Sciences and Health Services; Stem Cell Network","keywords":"Anaplastic thyroid cancer; Thyroid cancer; Cell culture; Valproic Acid; Cancer research; Medicine; Cell growth; Nestin; In vitro; Cellular differentiation; Cancer cell; Cell; Thyroid; Stem cell; Cancer; Internal medicine; Biology; Cell biology; Biochemistry; Epilepsy; Gene; Genetics","score_opus":0.03196368646026774,"score_gpt":0.35093010469558883,"score_spread":0.31896641823532107,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2018902367","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9649898,0.031107439,0.0013128283,0.00023605287,0.00007616752,0.00004645077,0.00036240125,0.000047572725,0.0018212462],"genre_scores_gemma":[0.9817695,0.0153070185,0.0012805859,0.00008817476,0.00003771934,0.00002953124,0.0004499725,0.000011653679,0.001025772],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999032,0.000026075919,0.000014683899,0.000013353735,0.000021147558,0.000021541984],"domain_scores_gemma":[0.99994004,0.000014451954,0.000015431471,0.0000068194163,0.000010158246,0.000013171988],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018633269,0.0003246348,0.00035521897,0.0002414042,0.00016233996,0.00028503354,0.00025922473,0.00022840909,0.000765603],"category_scores_gemma":[0.00010284064,0.00011059599,0.0005092885,0.00020589979,0.00021244673,0.0002327545,0.00012367139,0.00043192084,0.00014339203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012982815,0.0003290752,0.00074413815,0.00050157186,0.00004815967,0.00017882927,0.00004589979,0.0002237388,0.98221946,0.0001746459,0.00015556646,0.014080616],"study_design_scores_gemma":[0.00011147984,0.0064257937,0.0050815153,0.000024290955,0.00017576486,0.00036657247,0.000052330786,0.0005895403,0.98129797,0.000065688735,0.0058008237,0.000008164199],"about_ca_topic_score_codex":0.0010751022,"about_ca_topic_score_gemma":0.0014709613,"teacher_disagreement_score":0.0010751022,"about_ca_system_score_codex":0.00035489703,"about_ca_system_score_gemma":0.0002808842,"threshold_uncertainty_score":0.0025749803},"labels":[],"label_agreement":null},{"id":"W2020389231","doi":"10.1073/pnas.0709279105","title":"Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Calcitriol receptor; Nuclear receptor; Histone deacetylase; Trichostatin A; Chemistry; Transcription factor; Cell biology; Nuclear receptor co-repressor 1; Histone deacetylase 2; Acetylation; Biology; Biochemistry; Cancer research; Histone; Receptor; Gene","score_opus":0.022846736091892618,"score_gpt":0.3102622706092625,"score_spread":0.28741553451736984,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020389231","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9615926,0.007882885,0.017248504,0.00027679693,0.00029647394,0.00024922908,0.0008946515,0.00032175434,0.011237166],"genre_scores_gemma":[0.9829989,0.002891042,0.008252331,0.00014015479,0.000024905683,0.00007868858,0.0006705227,0.00002775183,0.004915622],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988735,0.0000117796335,0.000009352217,0.000038272592,0.000026165231,0.000027018934],"domain_scores_gemma":[0.999949,0.0000069185567,0.000014814881,0.00001039986,0.0000058030187,0.000013113546],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011548508,0.00031001674,0.00022159421,0.00013522699,0.00012363355,0.00023787715,0.00041315478,0.00024657985,0.0021388747],"category_scores_gemma":[0.000084051724,0.00015146278,0.00027313305,0.00016154196,0.00019726044,0.000161268,0.00014822565,0.0004493212,0.0006234296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022109241,0.00005012895,0.0001464433,0.00006828214,0.000024151683,0.00003898681,0.000012098648,0.00022463237,0.9927892,0.00053041056,0.000106520776,0.005788],"study_design_scores_gemma":[0.00007248913,0.0009548128,0.0005111825,0.0000048646734,0.000040817697,0.00013587136,0.0000110895135,0.0006031415,0.9871317,0.000040551724,0.010486498,0.0000069379194],"about_ca_topic_score_codex":0.0007919299,"about_ca_topic_score_gemma":0.001486401,"teacher_disagreement_score":0.0021388747,"about_ca_system_score_codex":0.00039527362,"about_ca_system_score_gemma":0.00035421713,"threshold_uncertainty_score":0.007155299},"labels":[],"label_agreement":null},{"id":"W2020805901","doi":"10.1016/j.bmcl.2008.12.048","title":"SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103)","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Benzamide; Chemistry; HDAC1; Histone deacetylase; Histone deacetylase inhibitor; In vivo; Small molecule; Acetylation; Pharmacokinetics; In vitro; Lead compound; Recombinant DNA; Cancer research; Histone; Biochemistry; Stereochemistry; Pharmacology","score_opus":0.04702229651429136,"score_gpt":0.2891897136069961,"score_spread":0.24216741709270473,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020805901","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98638886,0.0057959543,0.0018374984,0.00017342395,0.00008117697,0.00022705348,0.0010386679,0.00009005838,0.004367271],"genre_scores_gemma":[0.98970664,0.0037719004,0.0019295211,0.00009312304,0.000021571816,0.00008841787,0.0020496352,0.000014231094,0.0023249255],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999305,0.000014530618,0.000005661383,0.000011953836,0.000014614627,0.000022762431],"domain_scores_gemma":[0.9999074,0.0000150569,0.000017330898,0.0000110963565,0.00001437843,0.00003476345],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022777819,0.00031084273,0.00033047708,0.00016519125,0.00016659875,0.000271617,0.000480078,0.00025246097,0.001985475],"category_scores_gemma":[0.00022144172,0.0001428625,0.00026910278,0.00020038245,0.00021522587,0.0001695431,0.00010739564,0.0006172671,0.00048093378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028007461,0.0010692752,0.00056879566,0.00022734875,0.000050632665,0.00024376332,0.000059550544,0.0029391332,0.975546,0.00042032657,0.0006409649,0.015433485],"study_design_scores_gemma":[0.0025777393,0.028869107,0.006530406,0.00003705025,0.00027562634,0.0011821277,0.000067026405,0.0036438568,0.93994737,0.00014180697,0.016693106,0.000034717767],"about_ca_topic_score_codex":0.0022217468,"about_ca_topic_score_gemma":0.0031826713,"teacher_disagreement_score":0.0022217468,"about_ca_system_score_codex":0.00036394244,"about_ca_system_score_gemma":0.00043499714,"threshold_uncertainty_score":0.0066420436},"labels":[],"label_agreement":null},{"id":"W2022093757","doi":"10.2174/1568011054866946","title":"Histone Deacetylase Inhibitors: Latest Developments, Trends and Prospects","year":2005,"lang":"en","type":"review","venue":"Current Medicinal Chemistry - Anti-Cancer Agents","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"National Cancer Institute","keywords":"Histone deacetylase; Histone Acetyltransferases; Acetylation; HDAC11; Histone; Histone deacetylase 5; Histone deacetylase 2; Biochemistry; Vorinostat; Biology; Chemistry; Cancer research; Computational biology; Gene","score_opus":0.055492521552374156,"score_gpt":0.40989325685778166,"score_spread":0.3544007353054075,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022093757","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00036237575,0.9970241,0.00035208918,0.0003750591,0.00027017688,0.000008988589,0.000021498543,0.000019248359,0.0015663578],"genre_scores_gemma":[0.0014411673,0.995747,0.00060096994,0.00029064497,0.000276709,0.000010925667,0.000043941764,0.000002491197,0.0015860569],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998192,0.000023724851,0.00002204928,0.000038797836,0.00007606411,0.000020158575],"domain_scores_gemma":[0.9997949,0.00006407845,0.000035531884,0.000008239485,0.000061275954,0.00003606119],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007076147,0.0009407883,0.0013013863,0.0015359472,0.00023411239,0.0009387907,0.0009012672,0.0009368079,0.004585886],"category_scores_gemma":[0.00046323304,0.00031195575,0.00038553786,0.0016804769,0.00039400146,0.0015807202,0.0004468905,0.0015126049,0.0036110412],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000175739,0.00019438997,0.00015007146,0.005656421,0.000055095017,0.00034673128,0.000042149855,0.0005045875,0.0057553486,0.0033364627,0.024746006,0.95903695],"study_design_scores_gemma":[0.000063686624,0.00027171025,0.00060680025,0.00090544176,0.0000702499,0.0015909702,0.000044893783,0.0002125385,0.0024310662,0.0016120647,0.9921737,0.000016866103],"about_ca_topic_score_codex":0.00046362492,"about_ca_topic_score_gemma":0.001475154,"teacher_disagreement_score":0.004585886,"about_ca_system_score_codex":0.00060274004,"about_ca_system_score_gemma":0.0006037741,"threshold_uncertainty_score":0.0153413415},"labels":[],"label_agreement":null},{"id":"W2022577900","doi":"10.1002/prot.21407","title":"Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A","year":2007,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Wellcome Trust","keywords":"Histone acetyltransferase; Biology; PCAF; Histone Acetyltransferases; Histone methyltransferase; Acetyltransferase; Chromatin; Histone code; P300-CBP Transcription Factors; Acetylation; Chromatin remodeling; Histone H2A; Cell biology; Biochemistry; Gene; Nucleosome","score_opus":0.012140419055286102,"score_gpt":0.2728035486472495,"score_spread":0.26066312959196336,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022577900","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9110176,0.03717093,0.0091729965,0.0031786945,0.0014668342,0.00037209853,0.007974089,0.0018585365,0.02778816],"genre_scores_gemma":[0.9264774,0.01110267,0.012864206,0.0010041592,0.00015983454,0.00017547158,0.030925957,0.0002696193,0.01702079],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995772,0.00003539544,0.000013989017,0.00009094918,0.000213628,0.000068890775],"domain_scores_gemma":[0.99983704,0.000032869022,0.000022041431,0.000005890102,0.0000263563,0.0000758172],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045427243,0.0011515849,0.0011894539,0.00034704313,0.0010990493,0.0011747289,0.0017740172,0.0008489859,0.0071117114],"category_scores_gemma":[0.00063824694,0.0005863743,0.0003532025,0.0005695856,0.00034375506,0.00051675894,0.00061225926,0.0019141419,0.0013350161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.011380029,0.0032816876,0.02191791,0.0052479994,0.0022664557,0.008172378,0.001844035,0.029909058,0.6901735,0.017943215,0.12218445,0.08567931],"study_design_scores_gemma":[0.0049068304,0.0026767745,0.058913,0.000765478,0.0013242139,0.005921316,0.001610323,0.21392296,0.37529007,0.0040333145,0.33003715,0.00059852755],"about_ca_topic_score_codex":0.017030057,"about_ca_topic_score_gemma":0.021317404,"teacher_disagreement_score":0.017030057,"about_ca_system_score_codex":0.0029229035,"about_ca_system_score_gemma":0.0015650115,"threshold_uncertainty_score":0.033861876},"labels":[],"label_agreement":null},{"id":"W2024076463","doi":"10.1038/sj.onc.1207569","title":"Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-γ2, an estrogen-responsive kinase","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Cancer Institute; National Institutes of Health; Susan G. Komen; Susan G. Komen for the Cure","keywords":"Biology; Estrogen; Cyclin-dependent kinase 4; Kinase; Antigen; Cancer research; Casein kinase 1; Protein kinase A; Mitogen-activated protein kinase kinase; Cell biology; Immunology; Endocrinology","score_opus":0.01710805017969784,"score_gpt":0.30254814490780624,"score_spread":0.2854400947281084,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024076463","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9907032,0.005137646,0.0018875793,0.0002699392,0.000093002454,0.000014733731,0.00034421333,0.00009540719,0.0014544515],"genre_scores_gemma":[0.9887622,0.0015269713,0.0014279919,0.000083340354,0.00003591024,0.00002233506,0.0020854352,0.000033807755,0.006021995],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985445,0.000016566057,0.000008814309,0.00004563448,0.000039955226,0.000034525343],"domain_scores_gemma":[0.9997838,0.000020985402,0.000091910115,0.00001836937,0.000019423007,0.000065574415],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017639108,0.0005950777,0.00023631712,0.0003522856,0.00043506848,0.0005538696,0.00035668796,0.0002549799,0.0019183727],"category_scores_gemma":[0.00029869852,0.0003314985,0.0004099579,0.0002645517,0.00021432768,0.00029516473,0.00044089134,0.00046851538,0.0017666456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022928648,0.000029975046,0.0012750364,0.00004450312,0.00001619877,0.00014301918,0.000016937936,0.00011068627,0.996084,0.00019583035,0.00030138245,0.0015531894],"study_design_scores_gemma":[0.000046080022,0.00019142419,0.02865382,0.000015446903,0.000026789288,0.0019513298,0.00007857928,0.0031639654,0.9530438,0.00029377543,0.012521163,0.000013723403],"about_ca_topic_score_codex":0.0008051398,"about_ca_topic_score_gemma":0.0012579395,"teacher_disagreement_score":0.0019183727,"about_ca_system_score_codex":0.000896115,"about_ca_system_score_gemma":0.00025036905,"threshold_uncertainty_score":0.006501794},"labels":[],"label_agreement":null},{"id":"W2024175600","doi":"10.1038/srep07207","title":"Effects of histone deacetylase inhibitor valproic acid on skeletal myocyte development","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Histone deacetylase 5; Histone deacetylase; HDAC11; Histone; Histone deacetylase 2; Biology; Cell biology; Histone deacetylase inhibitor; Acetylation; HDAC4; Cellular differentiation; SAP30; Chemistry; Biochemistry; Gene","score_opus":0.0061773669512137745,"score_gpt":0.27122620487848176,"score_spread":0.26504883792726797,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024175600","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98216873,0.010740751,0.00097642484,0.0002980162,0.00014966402,0.000046724974,0.0009528355,0.00019815692,0.004468596],"genre_scores_gemma":[0.9878539,0.0056367107,0.0013266157,0.00013864119,0.000029325533,0.00004217934,0.0007702248,0.00003958311,0.0041628173],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999874,0.000025685888,0.000017338256,0.000024609282,0.000029735658,0.000028768256],"domain_scores_gemma":[0.9998171,0.00005371094,0.000032167347,0.000013040586,0.000021829626,0.00006225957],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014929801,0.00032840544,0.0004017774,0.00027500343,0.00013773945,0.00025659802,0.00024749018,0.00027519304,0.0012362471],"category_scores_gemma":[0.00020388173,0.00011331798,0.00020930855,0.00019162359,0.00019517234,0.0001460467,0.00015669089,0.00054992037,0.00024298228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017406547,0.00020762063,0.0004287825,0.00013431792,0.00002816372,0.0001395885,0.000037273632,0.0002849966,0.98947316,0.00015247671,0.00023510888,0.007137861],"study_design_scores_gemma":[0.00007203177,0.0016554758,0.0025098063,0.000011899186,0.000052323023,0.00008232847,0.000032154836,0.0005713816,0.99163544,0.000044355183,0.0033262093,0.000006582117],"about_ca_topic_score_codex":0.0016160666,"about_ca_topic_score_gemma":0.0027895083,"teacher_disagreement_score":0.0016160666,"about_ca_system_score_codex":0.00026158057,"about_ca_system_score_gemma":0.0006218028,"threshold_uncertainty_score":0.004135728},"labels":[],"label_agreement":null},{"id":"W2024202249","doi":"10.1038/sj.onc.1208585","title":"HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Susan G. Komen; Ryerson University; Gladstone Institutes; University of Pennsylvania; Susan G. Komen for the Cure","keywords":"Histone deacetylase; Apoptosis; Trichostatin A; Biology; Cancer research; Programmed cell death; Cancer cell; Histone deacetylase inhibitor; Transcription factor; Histone; Cancer; Biochemistry; Gene; Genetics","score_opus":0.006694935112778889,"score_gpt":0.2591063870797644,"score_spread":0.2524114519669855,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024202249","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9920365,0.0028364316,0.0006238442,0.00025820374,0.00009529035,0.00004621773,0.00032806006,0.00012849369,0.003646998],"genre_scores_gemma":[0.99428225,0.0018073132,0.00050919544,0.00005599866,0.000032440086,0.000023233331,0.00043817642,0.0000150496,0.002836386],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987197,0.000018548424,0.000011957994,0.0000067600113,0.000027768321,0.00006297812],"domain_scores_gemma":[0.9998565,0.000041253592,0.000018957271,0.00002512731,0.000018508785,0.000039648607],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018471146,0.00028342847,0.0004834263,0.0003746752,0.00026091977,0.0003608292,0.00016981248,0.00018028756,0.002101459],"category_scores_gemma":[0.00026994228,0.00016169404,0.00029235985,0.00034375853,0.00019781379,0.00028743912,0.00015474374,0.00085357623,0.00051646226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0048224283,0.0008304112,0.000948297,0.00016703362,0.00005033846,0.000156998,0.000057050576,0.0007292567,0.96843296,0.0006007834,0.0012415644,0.021962816],"study_design_scores_gemma":[0.00054960133,0.0035308632,0.005310315,0.000013540004,0.00007708739,0.00034089613,0.000056567103,0.0013130878,0.9837548,0.00014987797,0.004893407,0.000009879718],"about_ca_topic_score_codex":0.0012756226,"about_ca_topic_score_gemma":0.0038514868,"teacher_disagreement_score":0.002101459,"about_ca_system_score_codex":0.0005804664,"about_ca_system_score_gemma":0.0006043729,"threshold_uncertainty_score":0.00703007},"labels":[],"label_agreement":null},{"id":"W2024960352","doi":"10.1158/1538-7445.pedcan-b45","title":"Abstract B45: A novel therapeutic approach for neuroblastoma","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Neuroblastoma; SOX2; Cancer research; Tumor progression; Metastasis; Biology; Cell culture; Cancer; Chemistry; Molecular biology; Internal medicine; Medicine; Biochemistry; Transcription factor","score_opus":0.07683666766544858,"score_gpt":0.3962251027473787,"score_spread":0.31938843508193016,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024960352","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92306775,0.04744092,0.009058585,0.0008828917,0.00038803046,0.0004410427,0.001359292,0.00041356968,0.01694794],"genre_scores_gemma":[0.9704892,0.018097604,0.0037227757,0.00025456134,0.000046570345,0.0001281246,0.0007439046,0.000016973096,0.0065001417],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999634,0.0000062517606,0.0000029604766,0.000007806128,0.0000094273455,0.000010115425],"domain_scores_gemma":[0.99998915,0.000001069847,0.0000020177977,0.0000010853947,0.0000013487348,0.000005364899],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007700976,0.00029526182,0.00024586925,0.00026196145,0.00014066965,0.0002472112,0.00025959918,0.0002790084,0.0017355275],"category_scores_gemma":[0.00002987405,0.000077800374,0.00022996495,0.00015253908,0.00013090216,0.00013850202,0.00017583172,0.0005169028,0.00040922343],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00069965055,0.0003697808,0.00042388667,0.00043053934,0.00004809653,0.00033720615,0.00004945702,0.0005119368,0.94573444,0.0011645601,0.0010045676,0.049225736],"study_design_scores_gemma":[0.000877679,0.010290355,0.011753557,0.0001545959,0.0003128333,0.002953455,0.000117930125,0.0024612078,0.8634695,0.0005720237,0.106994785,0.00004205409],"about_ca_topic_score_codex":0.0016044046,"about_ca_topic_score_gemma":0.0034044774,"teacher_disagreement_score":0.0017355275,"about_ca_system_score_codex":0.00023669413,"about_ca_system_score_gemma":0.00032133516,"threshold_uncertainty_score":0.0058059692},"labels":[],"label_agreement":null},{"id":"W2025081376","doi":"10.1186/1471-2202-12-50","title":"Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells","year":2011,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Center for Neuroscience and Regenerative Medicine","keywords":"Sodium butyrate; Histone deacetylase; Chemistry; Subventricular zone; Histone deacetylase inhibitor; Cancer research; Cell biology; Histone; Neuroscience; Biology; Biochemistry; Stem cell; Neural stem cell","score_opus":0.011547557028877548,"score_gpt":0.2578824564620386,"score_spread":0.24633489943316106,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2025081376","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9918359,0.0034072886,0.002218782,0.00007777393,0.000040602536,0.000044985365,0.0006683593,0.00012195716,0.0015845281],"genre_scores_gemma":[0.9904839,0.0026090618,0.0024015354,0.000044857985,0.000013958597,0.000079180754,0.0012037012,0.000027272508,0.0031366048],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993384,0.0000075304697,0.000009392911,0.000011429193,0.000020271535,0.000017497901],"domain_scores_gemma":[0.9999341,0.000011349503,0.00001869861,0.000007769256,0.000008580611,0.00001945357],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000723998,0.00039981143,0.00024702813,0.00019921921,0.000103076854,0.000120399905,0.00022093387,0.00012818372,0.0016190229],"category_scores_gemma":[0.00005137206,0.000084377854,0.00024237561,0.00010991493,0.00015391775,0.000107148095,0.00010904311,0.00037156604,0.0003874571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012273737,0.000029916795,0.0001379585,0.000028494283,0.000005612313,0.000024424431,0.000007414098,0.00003656443,0.9984486,0.000024234037,0.000028158207,0.0011058686],"study_design_scores_gemma":[0.000013705501,0.00031664176,0.0019308734,0.0000027716374,0.0000080939935,0.000052801715,0.000009236457,0.00021664417,0.99662375,0.000011798307,0.0008129028,8.1772697e-7],"about_ca_topic_score_codex":0.000938208,"about_ca_topic_score_gemma":0.002209753,"teacher_disagreement_score":0.0016190229,"about_ca_system_score_codex":0.00023088968,"about_ca_system_score_gemma":0.00021885092,"threshold_uncertainty_score":0.005416155},"labels":[],"label_agreement":null},{"id":"W2025818448","doi":"10.1016/j.ijdevneu.2013.03.008","title":"HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain","year":2013,"lang":"en","type":"article","venue":"International Journal of Developmental Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Science Council; Michael Smith Health Research BC","keywords":"Subventricular zone; Neurogenesis; Neurosphere; Neural stem cell; Biology; Dentate gyrus; Neuroscience; Nestin; Progenitor cell; Cell biology; Central nervous system; Cellular differentiation; Stem cell; Adult stem cell; Biochemistry","score_opus":0.012809410729560542,"score_gpt":0.2673680718172596,"score_spread":0.25455866108769903,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2025818448","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9807078,0.007867362,0.0039340565,0.000273824,0.00018530615,0.00010652366,0.0018890668,0.0004941248,0.0045419913],"genre_scores_gemma":[0.976108,0.0056367745,0.0042408705,0.00016796065,0.00005509253,0.0002127825,0.0016174946,0.0001492298,0.01181178],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99964404,0.000026093538,0.000034986544,0.000096234246,0.00010471492,0.00009380939],"domain_scores_gemma":[0.9998586,0.000015566073,0.000040160383,0.00001920193,0.000014019243,0.000052353145],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016905156,0.00064560305,0.00049442786,0.00087548484,0.00021048973,0.0004766067,0.0003815657,0.00037529995,0.0018902302],"category_scores_gemma":[0.00008298722,0.00030175317,0.00042948252,0.00030390435,0.0004228304,0.0002821742,0.00018990618,0.0011943192,0.00079255685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015575862,0.000090157264,0.00020116201,0.000033501656,0.000010577544,0.000050188115,0.000022144974,0.00003621505,0.99719477,0.00015852091,0.00007818625,0.0019688786],"study_design_scores_gemma":[0.000027967117,0.0004952307,0.0031294485,0.0000082164925,0.00003004431,0.00009945547,0.000030379622,0.00043754902,0.99329424,0.000053646014,0.0023899162,0.0000038871676],"about_ca_topic_score_codex":0.0013254175,"about_ca_topic_score_gemma":0.0024552273,"teacher_disagreement_score":0.0018902302,"about_ca_system_score_codex":0.00044199615,"about_ca_system_score_gemma":0.0003116695,"threshold_uncertainty_score":0.0063235164},"labels":[],"label_agreement":null},{"id":"W2025836097","doi":"10.1182/blood-2011-01-330019","title":"A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Haematopoiesis; Leukemia; In vivo; Myeloid leukemia; Stem cell; Progenitor cell; Myeloid; CD34; Cancer research; Biology; Immunology; Cell biology; Genetics","score_opus":0.060345238641999824,"score_gpt":0.27290552642472926,"score_spread":0.21256028778272945,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2025836097","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97008073,0.003551991,0.014539592,0.0002591069,0.000037231257,0.0009776424,0.0032193414,0.00055493275,0.0067795916],"genre_scores_gemma":[0.9764214,0.0038673808,0.011426506,0.0001144086,0.000010054414,0.0003560208,0.002728707,0.0000680048,0.0050075916],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997979,0.0000390074,0.000016578584,0.00005531125,0.00005747063,0.00003382977],"domain_scores_gemma":[0.9998809,0.000020536156,0.000026787875,0.000020543031,0.000032322547,0.000018823337],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026942932,0.00079835096,0.0005265536,0.0005516599,0.00027258386,0.00031706685,0.0003265575,0.00032188153,0.0018387553],"category_scores_gemma":[0.00024005759,0.00018080574,0.00028821186,0.0005039349,0.00030179086,0.0001967375,0.00023274872,0.0005309299,0.0006259054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024221715,0.00022526731,0.00046173565,0.00011320122,0.000018866382,0.00008491237,0.000040746723,0.0009035712,0.9852997,0.00017677051,0.00025074556,0.0121822385],"study_design_scores_gemma":[0.00012046184,0.00407544,0.0025849026,0.000012327988,0.000056413795,0.0002735101,0.000026185558,0.000874518,0.9872457,0.000053096173,0.004661457,0.000015988511],"about_ca_topic_score_codex":0.0019498606,"about_ca_topic_score_gemma":0.0053416416,"teacher_disagreement_score":0.0019498606,"about_ca_system_score_codex":0.0006622296,"about_ca_system_score_gemma":0.0005224486,"threshold_uncertainty_score":0.0061511993},"labels":[],"label_agreement":null},{"id":"W2026356631","doi":"10.1093/neuonc/nou237.33","title":"AT-33A PHASE II STUDY OF CONCURRENT RADIATION THERAPY, TEMOZOLOMIDE AND THE HISTONE DEACETYLASE INHIBITOR VALPROIC ACID FOR PATIENTS WITH GLIOBLASTOMA MULTIFORME","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lakeridge Health","funders":"","keywords":"Temozolomide; Medicine; Valproic Acid; Internal medicine; Phases of clinical research; Radiation therapy; Oncology; Toxicity; Gastroenterology; Epilepsy","score_opus":0.010233742081879358,"score_gpt":0.3051719867733026,"score_spread":0.2949382446914232,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026356631","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99480444,0.0016521032,0.0003843402,0.00034706685,0.000063016814,0.0015663003,0.00048935076,0.000047379974,0.0006461155],"genre_scores_gemma":[0.9908999,0.0017395568,0.0016277044,0.00044137807,0.00014132296,0.0023294433,0.0014155613,0.000021224449,0.0013839512],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9995858,0.00021076798,0.000016624906,0.00006580421,0.000034341367,0.00008663555],"domain_scores_gemma":[0.9993319,0.000064150256,0.000103096536,0.000036762445,0.00004258361,0.00042160353],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001465475,0.0017276453,0.0021180192,0.00052457507,0.00048410211,0.0007835313,0.0009831303,0.0010929608,0.003559514],"category_scores_gemma":[0.0005990221,0.0007434205,0.0014211606,0.00056900637,0.0010960993,0.0005903159,0.00036286862,0.0028157707,0.00078965747],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.77031034,0.07658495,0.015191438,0.0008935264,0.0017310398,0.00051574304,0.00047382095,0.0033461708,0.049778577,0.000449612,0.003268973,0.07745581],"study_design_scores_gemma":[0.39020768,0.5849279,0.01737611,0.00004881423,0.0005278105,0.00039973092,0.00006130669,0.00093735027,0.002663478,0.00018671654,0.002634698,0.000028297078],"about_ca_topic_score_codex":0.0024951834,"about_ca_topic_score_gemma":0.0054964563,"teacher_disagreement_score":0.003559514,"about_ca_system_score_codex":0.0012131389,"about_ca_system_score_gemma":0.0028588155,"threshold_uncertainty_score":0.011907697},"labels":[],"label_agreement":null},{"id":"W2026514678","doi":"10.1007/s10571-012-9859-6","title":"Co-location of HDAC2 and Insulin Signaling Components in the Adult Mouse Hippocampus","year":2012,"lang":"en","type":"article","venue":"Cellular and Molecular Neurobiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Peking Union Medical College; Nunavut General Monitoring Plan","keywords":"Hippocampus; Neuroscience; Insulin; Biology; Endocrinology","score_opus":0.013757294521354154,"score_gpt":0.2519747899154995,"score_spread":0.23821749539414533,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026514678","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9798164,0.007566268,0.0067101666,0.0003151985,0.00015258671,0.000013467315,0.0011528207,0.00022842105,0.0040448136],"genre_scores_gemma":[0.9775958,0.0022036203,0.0053200806,0.00011664257,0.000042595075,0.000041057538,0.00087205885,0.00012777238,0.013680255],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997559,0.000008055584,0.00001391308,0.00008077844,0.00007922684,0.000062021216],"domain_scores_gemma":[0.99971277,0.000015206443,0.000099081706,0.000022446848,0.000045228226,0.00010520852],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016332464,0.00051992916,0.00048030936,0.0011174175,0.00026431368,0.0008424986,0.00042437215,0.0003078446,0.001723275],"category_scores_gemma":[0.0001353316,0.0005764287,0.0004039249,0.0004028977,0.00043762277,0.0005590879,0.00049864734,0.0010450712,0.0005993919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025515366,0.000009301952,0.0007580391,0.000030176636,0.000013882184,0.00016229754,0.000019078303,0.000035666362,0.9967475,0.00020390112,0.00006751627,0.0016975281],"study_design_scores_gemma":[0.000048729427,0.00012905519,0.043076213,0.000016132923,0.0000754398,0.0012139077,0.00022993481,0.0005467823,0.9516135,0.00027456234,0.0027618755,0.000013906732],"about_ca_topic_score_codex":0.0026421756,"about_ca_topic_score_gemma":0.005263151,"teacher_disagreement_score":0.0026421756,"about_ca_system_score_codex":0.0008182712,"about_ca_system_score_gemma":0.0004508327,"threshold_uncertainty_score":0.0059369802},"labels":[],"label_agreement":null},{"id":"W2027101907","doi":"10.1016/j.cell.2012.02.064","title":"Exploring the Yeast Acetylome Using Functional Genomics","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; University of Toronto","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Acetylation; Biology; Lysine; Yeast; Functional genomics; Histone; Transcription factor; Gene; Saccharomyces cerevisiae; Genetics; Cell biology; Biochemistry; Genomics; Genome; Amino acid","score_opus":0.10257328819318492,"score_gpt":0.2732459236063986,"score_spread":0.17067263541321367,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2027101907","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82819146,0.009758125,0.1473805,0.0023953589,0.00012993331,0.000068586436,0.003940474,0.000697138,0.007438494],"genre_scores_gemma":[0.91976035,0.009901786,0.06465224,0.00042210508,0.00004045079,0.00003970466,0.0032696081,0.00013580552,0.0017779934],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999403,0.0000082089155,0.000003000302,0.00001635661,0.000019590978,0.000012603153],"domain_scores_gemma":[0.99989855,0.000037891463,0.000016187696,0.000013166668,0.000015982103,0.00001823456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025144534,0.00045264667,0.00035130882,0.0005510353,0.00034940662,0.0007450798,0.0004383186,0.00031420213,0.0011628285],"category_scores_gemma":[0.00019311352,0.00019866362,0.00046235582,0.00055029185,0.00039499448,0.0006132404,0.00033380793,0.0009170828,0.00032145862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017046968,0.00001758014,0.001030708,0.00009697271,0.00002450566,0.000080134014,0.000025248011,0.0011440057,0.9862748,0.002526037,0.00011489774,0.00849471],"study_design_scores_gemma":[0.000044522654,0.00020939345,0.01325702,0.000038046343,0.00012613578,0.000594101,0.0002485907,0.01297389,0.9427489,0.011343684,0.018383753,0.00003198551],"about_ca_topic_score_codex":0.002551961,"about_ca_topic_score_gemma":0.0035527807,"teacher_disagreement_score":0.002551961,"about_ca_system_score_codex":0.00058709853,"about_ca_system_score_gemma":0.0004404213,"threshold_uncertainty_score":0.0050742626},"labels":[],"label_agreement":null},{"id":"W2028418967","doi":"10.1016/j.advenzreg.2007.11.016","title":"Nuclear organization and chromatin dynamics – Sp1, Sp3 and histone deacetylases","year":2008,"lang":"en","type":"review","venue":"Advances in Enzyme Regulation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Canada Research Chairs; CancerCare Manitoba Foundation","keywords":"Chromatin; Chemistry; Histone; Cell biology; Chromatin remodeling; Biology; Biochemistry; DNA","score_opus":0.008918636666387115,"score_gpt":0.30841045171533077,"score_spread":0.2994918150489437,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2028418967","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00013744738,0.99821234,0.00025674806,0.00034182656,0.00036163384,0.000002815918,0.0000109694,0.000007290379,0.0006688542],"genre_scores_gemma":[0.0007881363,0.9971733,0.00024831225,0.00027217384,0.0005297712,0.000005652954,0.000030395477,0.0000015632102,0.0009506249],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99981827,0.000022515555,0.000021237332,0.000044651988,0.00007393883,0.00001953944],"domain_scores_gemma":[0.9997942,0.00007994081,0.000029220824,0.00001098029,0.00006432074,0.000021317253],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006811081,0.0010763095,0.0016553222,0.0010540672,0.00030429865,0.0010475817,0.001343087,0.0015818712,0.002368286],"category_scores_gemma":[0.0005151672,0.00045089866,0.0003765973,0.0016897402,0.00087824237,0.001699219,0.0006510408,0.0021029026,0.0023405042],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002456164,0.000086750704,0.00024562178,0.008919592,0.00010042281,0.00030213548,0.000056068926,0.0009910146,0.014383175,0.0071659456,0.0532182,0.9142853],"study_design_scores_gemma":[0.00003791951,0.00008773556,0.0010224199,0.00083855697,0.000077582095,0.0009298432,0.00005577051,0.00020159857,0.0023596925,0.0044010067,0.98996323,0.000024572571],"about_ca_topic_score_codex":0.0011477749,"about_ca_topic_score_gemma":0.0019864512,"teacher_disagreement_score":0.002368286,"about_ca_system_score_codex":0.0008589055,"about_ca_system_score_gemma":0.0007748023,"threshold_uncertainty_score":0.007922649},"labels":[],"label_agreement":null},{"id":"W2029679395","doi":"10.1517/14728222.2013.729042","title":"Targeting class I histone deacetylases in cancer therapy","year":2012,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"HDAC8; Histone deacetylase; Histone; Histone deacetylase 5; Epigenetics; Biology; HDAC1; Cancer research; HDAC11; Cancer; Cancer cell; Gene; Genetics","score_opus":0.10723395404369976,"score_gpt":0.4323709437233718,"score_spread":0.3251369896796721,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2029679395","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00013620358,0.9958865,0.0003231611,0.0008583628,0.0006313084,0.00001108728,0.000027847273,0.000022631297,0.0021028628],"genre_scores_gemma":[0.000942779,0.9961128,0.00037239958,0.0005131019,0.00033771872,0.000012335137,0.000046765064,0.0000031837594,0.0016588093],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998385,0.000027755928,0.000012158994,0.000028829521,0.00007242124,0.000020321762],"domain_scores_gemma":[0.99985135,0.000044207412,0.000024492267,0.0000054643483,0.000054714168,0.000019784],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044648044,0.0007956541,0.0010172074,0.0011223995,0.00022382937,0.0006173736,0.00084440253,0.0011340642,0.0052697654],"category_scores_gemma":[0.00041188815,0.00019028645,0.00044846477,0.0011832588,0.00043354943,0.0009167071,0.0005527863,0.0025144734,0.004511525],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000087572815,0.00007471087,0.00008527092,0.00769836,0.00006638386,0.00016823274,0.00003253788,0.00045503266,0.0034811047,0.0043242206,0.07501856,0.9085081],"study_design_scores_gemma":[0.000025887699,0.000076309894,0.00028138442,0.0013405543,0.000045772424,0.0007336282,0.000018227876,0.00010539305,0.000632342,0.0015220677,0.99520713,0.000011247834],"about_ca_topic_score_codex":0.0010366426,"about_ca_topic_score_gemma":0.0022262586,"teacher_disagreement_score":0.0052697654,"about_ca_system_score_codex":0.00084952894,"about_ca_system_score_gemma":0.00070546777,"threshold_uncertainty_score":0.017629147},"labels":[],"label_agreement":null},{"id":"W2030182551","doi":"10.1016/j.mcn.2011.06.012","title":"Histone deacetylase inhibition promotes Caspase-independent cell death of ventral midbrain neurons","year":2011,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Parkinson Canada; Parkinson Society Canada","keywords":"Biology; Programmed cell death; Histone deacetylase; Cell biology; Midbrain; Progenitor cell; Apoptosis; Histone deacetylase inhibitor; Caspase; Population; Neuroscience; Histone; Stem cell; Central nervous system; Biochemistry","score_opus":0.02030191674016098,"score_gpt":0.2518242201659671,"score_spread":0.23152230342580613,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030182551","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9924273,0.0024644695,0.0019420444,0.00020568313,0.00007745411,0.000030028852,0.00048304413,0.00008356524,0.0022863513],"genre_scores_gemma":[0.9945657,0.0014567707,0.0008685661,0.0000654155,0.000018352874,0.000028658076,0.000528243,0.000023103608,0.0024452128],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980253,0.00001719152,0.000022713268,0.000032565273,0.000053190786,0.00007176679],"domain_scores_gemma":[0.9998584,0.000037151203,0.000026803447,0.000024284947,0.000016776528,0.000036578644],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020007546,0.000430616,0.00054180267,0.00033542802,0.0002695146,0.00049297797,0.000520298,0.00033964406,0.0017444729],"category_scores_gemma":[0.00020142952,0.00022616272,0.00055140967,0.0002812556,0.00032177134,0.00032911505,0.00023517416,0.0015623835,0.00042986256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007002696,0.0000982425,0.00020232105,0.00006851418,0.000035266898,0.00013748302,0.00003136,0.00010903791,0.99577147,0.0002355257,0.0001370224,0.0024735064],"study_design_scores_gemma":[0.000093573435,0.000373189,0.0032678922,0.0000074438185,0.0000311936,0.00019795276,0.000040027404,0.00071193976,0.99429613,0.00008700868,0.00088918244,0.000004556998],"about_ca_topic_score_codex":0.001849945,"about_ca_topic_score_gemma":0.0041408427,"teacher_disagreement_score":0.001849945,"about_ca_system_score_codex":0.0006984184,"about_ca_system_score_gemma":0.0004780215,"threshold_uncertainty_score":0.005835891},"labels":[],"label_agreement":null},{"id":"W2030301626","doi":"10.1016/j.bmcl.2007.06.006","title":"Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Valproic Acid; Histone deacetylase; Trichostatin A; Histone deacetylase inhibitor; Chemistry; Histone deacetylase 5; Histone deacetylase 2; Histone; HDAC10; Acetylation; HDAC11; Chaperone (clinical); Pharmacology; Biochemistry; Cell biology; Cancer research; Epilepsy; Biology; Medicine; Gene; Neuroscience","score_opus":0.008279626108252516,"score_gpt":0.2666140904892953,"score_spread":0.2583344643810428,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030301626","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.985993,0.005411216,0.0032188513,0.00041368764,0.00018042546,0.0000623743,0.0011114446,0.00055461866,0.0030543702],"genre_scores_gemma":[0.9947391,0.0009572667,0.0014799624,0.00007258936,0.000034431327,0.000029529929,0.0009791207,0.0000729787,0.0016351863],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973077,0.000038547456,0.00003181189,0.000049882972,0.000058937603,0.000089972964],"domain_scores_gemma":[0.99975187,0.000041395007,0.000075376454,0.00004675475,0.000026930284,0.000057707657],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016224124,0.00080812786,0.0008334415,0.00033224394,0.00020051013,0.00044970238,0.00033444114,0.0002961702,0.0014961938],"category_scores_gemma":[0.000283133,0.00022554232,0.00043346517,0.0002406674,0.0003321619,0.00024061465,0.0003217815,0.0007032017,0.0006777608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005574591,0.000030979292,0.00008765676,0.000037002406,0.000010824635,0.00010644986,0.0000080902,0.00006475584,0.9973212,0.0000695253,0.000084601095,0.0016214454],"study_design_scores_gemma":[0.00002734844,0.00015386924,0.0012144851,0.0000032253038,0.000007713437,0.00014309879,0.000008281389,0.00023767684,0.9973725,0.000037102156,0.0007912134,0.0000034807294],"about_ca_topic_score_codex":0.00062307145,"about_ca_topic_score_gemma":0.00078626885,"teacher_disagreement_score":0.0014961938,"about_ca_system_score_codex":0.00054409524,"about_ca_system_score_gemma":0.00028204697,"threshold_uncertainty_score":0.0050053},"labels":[],"label_agreement":null},{"id":"W2032395096","doi":"10.1007/s00280-013-2237-3","title":"A clinical investigation of inhibitory effect of panobinostat on CYP2D6 substrate in patients with advanced cancer","year":2013,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Novartis Pharmaceuticals Corporation","keywords":"Panobinostat; Medicine; Pharmacology; Active metabolite; Metabolite; CYP2D6; Pharmacokinetics; Internal medicine; Chemistry; Biochemistry","score_opus":0.008480293005227362,"score_gpt":0.3258972695176337,"score_spread":0.31741697651240636,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2032395096","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98739547,0.007685608,0.0002922014,0.00022949003,0.000049105656,0.00011766675,0.00047387017,0.000022042443,0.0037345577],"genre_scores_gemma":[0.9962786,0.0018545158,0.00029561378,0.00018264032,0.00005045495,0.000048038226,0.0004440529,0.000003548722,0.0008425241],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9997254,0.00010367389,0.000030004458,0.000056230096,0.000055476285,0.000029267507],"domain_scores_gemma":[0.999574,0.00011264208,0.000111153444,0.00002493735,0.00006833717,0.00010895064],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046027298,0.00030374184,0.0007584933,0.0002722439,0.00027262987,0.00037359522,0.00016803876,0.00029785364,0.0014600737],"category_scores_gemma":[0.0008897078,0.00014145167,0.00036944027,0.0006010821,0.0002128849,0.0002526399,0.00014498759,0.00059779844,0.00021786075],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.07583482,0.0021422508,0.7360524,0.00063534355,0.0010358309,0.0011694446,0.00027006888,0.00047002625,0.036895145,0.00026389956,0.0012501455,0.1439806],"study_design_scores_gemma":[0.004939556,0.051721275,0.9131978,0.00005537662,0.0016064717,0.0026274093,0.000307889,0.00086820027,0.013383281,0.00023306088,0.011025382,0.00003423064],"about_ca_topic_score_codex":0.0005141988,"about_ca_topic_score_gemma":0.0009959134,"teacher_disagreement_score":0.0014600737,"about_ca_system_score_codex":0.00026285235,"about_ca_system_score_gemma":0.00037174337,"threshold_uncertainty_score":0.004884422},"labels":[],"label_agreement":null},{"id":"W2034350901","doi":"10.1016/j.bmcl.2006.06.090","title":"Exploring alternative Zn-binding groups in the design of HDAC inhibitors: Squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Consiglio Nazionale delle Ricerche","keywords":"Squaric acid; Chemistry; Oxazoline; Stereochemistry; Hydroxamic acid; Hydroxymethyl; Enzyme inhibitor; Cytotoxicity; Chemical synthesis; Structure–activity relationship; Cell culture; Biochemistry; In vitro; Organic chemistry","score_opus":0.037498026638675734,"score_gpt":0.25060796025748855,"score_spread":0.2131099336188128,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034350901","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9584976,0.00809382,0.025532577,0.00049930025,0.00013233119,0.0003351172,0.0002958053,0.00032687656,0.006286528],"genre_scores_gemma":[0.97991097,0.0035622432,0.014218621,0.0001429334,0.000022625014,0.00009517823,0.00025652774,0.00002329093,0.0017675583],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998901,0.00002709389,0.000013357687,0.00002362973,0.000022282575,0.000023491653],"domain_scores_gemma":[0.99991095,0.000013731535,0.000021656535,0.000007851163,0.000021361118,0.000024394838],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375479,0.00041431218,0.00048512878,0.0002258085,0.0002288719,0.00036258504,0.0009673841,0.00036914667,0.0011852628],"category_scores_gemma":[0.000266262,0.00021112004,0.00025320056,0.00020772856,0.00032049682,0.00042258058,0.00030166458,0.0004771697,0.0003523056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018534866,0.00018980408,0.0003861353,0.00031481413,0.00003745367,0.00031893083,0.000086996726,0.003181967,0.9669002,0.0022286142,0.00026957566,0.024231924],"study_design_scores_gemma":[0.0008944669,0.003276483,0.00061097107,0.000033508204,0.00011018038,0.00039460763,0.000054921096,0.004241736,0.975132,0.000449507,0.014767034,0.000034605317],"about_ca_topic_score_codex":0.0012790845,"about_ca_topic_score_gemma":0.0028885633,"teacher_disagreement_score":0.0012790845,"about_ca_system_score_codex":0.00041937915,"about_ca_system_score_gemma":0.0003850378,"threshold_uncertainty_score":0.0039651394},"labels":[],"label_agreement":null},{"id":"W2034614265","doi":"10.1016/j.molcel.2008.07.002","title":"Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications","year":2008,"lang":"en","type":"review","venue":"Molecular Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":987,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute","keywords":"SUMO protein; Acetylation; Lysine; Crosstalk; Biology; Histone; Histone-modifying enzymes; Chromatin; Cell biology; Phosphorylation; Ubiquitin; Epigenetics; Biochemistry; Histone methyltransferase; DNA; Gene; Amino acid","score_opus":0.03433144724179447,"score_gpt":0.3184787982262896,"score_spread":0.2841473509844951,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034614265","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00049170817,0.9944665,0.0014189394,0.00039394107,0.00079127133,0.000005169588,0.000021648542,0.000021794542,0.002388969],"genre_scores_gemma":[0.002830942,0.99341077,0.0008293024,0.00037180792,0.00044984475,0.00001070206,0.000042251242,0.0000034070692,0.0020510796],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99984074,0.000018036348,0.000017781224,0.00004653443,0.000055175537,0.000021751257],"domain_scores_gemma":[0.9998739,0.000039990005,0.000022794615,0.000009553694,0.000035829315,0.000017880237],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005342282,0.0013810477,0.0018490658,0.0008697494,0.0002933404,0.001295127,0.0013900712,0.0012160155,0.0019775718],"category_scores_gemma":[0.00026661,0.00037527594,0.00033530378,0.0016444973,0.00085414905,0.0016372552,0.0006940819,0.0017738129,0.002144356],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025559653,0.000070465096,0.00030735065,0.007853258,0.00014942349,0.00068278005,0.00006501511,0.000672535,0.027640479,0.013220312,0.02257139,0.92651147],"study_design_scores_gemma":[0.00004158381,0.00009930267,0.0009700117,0.0007209619,0.00013893763,0.0023585577,0.00008307294,0.00020942834,0.010653083,0.0064231977,0.9782694,0.00003250944],"about_ca_topic_score_codex":0.00047625386,"about_ca_topic_score_gemma":0.0012592773,"teacher_disagreement_score":0.0019775718,"about_ca_system_score_codex":0.0007825024,"about_ca_system_score_gemma":0.00063557725,"threshold_uncertainty_score":0.006615579},"labels":[],"label_agreement":null},{"id":"W2035046057","doi":"10.1111/j.1582-4934.2008.00571.x","title":"Targeting histone deacetylases for the treatment of disease","year":2008,"lang":"en","type":"review","venue":"Journal of Cellular and Molecular Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Trinity College","funders":"National Science Council","keywords":"Histone deacetylase; Histone Acetyltransferases; Histone deacetylase 5; Histone; Acetylation; Histone deacetylase 2; HDAC11; HDAC4; Biology; Cancer research; Histone acetyltransferase; Cell biology; Genetics; DNA","score_opus":0.02739609248314498,"score_gpt":0.34745681491292835,"score_spread":0.32006072242978334,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035046057","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00012100247,0.9935347,0.00046031526,0.0012637977,0.0016678241,0.000012802641,0.000024669736,0.000023444494,0.0028914772],"genre_scores_gemma":[0.00084908557,0.9934001,0.00059761025,0.0010205029,0.0009281551,0.00001528822,0.00003816684,0.000004251572,0.0031468614],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99980265,0.000029092664,0.000022344038,0.000036943762,0.000089933965,0.000019049165],"domain_scores_gemma":[0.99974996,0.00009903844,0.000034051838,0.00001177642,0.00007583633,0.000029398672],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054133136,0.0010428623,0.0011086505,0.0019457334,0.00026350876,0.00062033365,0.00090643705,0.0013690771,0.0055334195],"category_scores_gemma":[0.00057096046,0.00025508011,0.00048012554,0.0014817852,0.0007346558,0.001272604,0.0005403921,0.0029337713,0.0038214],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013332552,0.00008957166,0.00014393094,0.008838624,0.0000918543,0.00048341928,0.00006966872,0.0004531343,0.00639802,0.008262143,0.11948845,0.8555479],"study_design_scores_gemma":[0.000034733246,0.00007257784,0.0003598355,0.0009219954,0.00003583094,0.0012599797,0.000023889026,0.00006572896,0.0008184973,0.0020949976,0.9942986,0.000013196221],"about_ca_topic_score_codex":0.0010335693,"about_ca_topic_score_gemma":0.0021900993,"teacher_disagreement_score":0.0055334195,"about_ca_system_score_codex":0.000822857,"about_ca_system_score_gemma":0.0006383616,"threshold_uncertainty_score":0.018511176},"labels":[],"label_agreement":null},{"id":"W2035281961","doi":"10.1113/jphysiol.2009.185595","title":"Exercise-induced histone acetylation - playing tag with the genome","year":2010,"lang":"en","type":"letter","venue":"The Journal of Physiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; York University","funders":"","keywords":"Histone; Histone deacetylase 5; Epigenetics; Biology; Acetylation; Endurance training; Chromatin remodeling; Histone acetyltransferase; SAP30; HDAC4; Cell biology; Histone deacetylase; Genetics; Endocrinology; Gene","score_opus":0.013546787714270451,"score_gpt":0.2725900201321238,"score_spread":0.2590432324178534,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035281961","genre_codex":"empirical","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"commentary","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7397963,0.077991515,0.067366645,0.006984332,0.0070442813,0.00023222365,0.029914435,0.0046952246,0.06597507],"genre_scores_gemma":[0.9033496,0.013587367,0.01758007,0.0033308645,0.00062147964,0.00013158355,0.015600473,0.00034921194,0.04544949],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998179,0.000010086549,0.0000064081732,0.00008736089,0.000049961884,0.000028314309],"domain_scores_gemma":[0.9998622,0.000011767907,0.000039717444,0.000028776149,0.000024125646,0.000033445824],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452832,0.00023898359,0.00030426035,0.00033318062,0.00020093806,0.0007255773,0.00031385545,0.0004154805,0.0063438313],"category_scores_gemma":[0.00026302785,0.00015724722,0.00034499244,0.00068552274,0.00019285922,0.00032004248,0.0005228237,0.00076098344,0.0032413863],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005522544,0.00008854097,0.015636722,0.00043068966,0.0001902837,0.00030777286,0.00010411076,0.00027676136,0.838601,0.0032038311,0.014343671,0.1262645],"study_design_scores_gemma":[0.00009089669,0.00086951425,0.42244297,0.00014672033,0.00037442736,0.0019513583,0.00023947287,0.0035119758,0.2671284,0.0051228036,0.29805082,0.00007070668],"about_ca_topic_score_codex":0.0008430254,"about_ca_topic_score_gemma":0.0014275707,"teacher_disagreement_score":0.0063438313,"about_ca_system_score_codex":0.00030266852,"about_ca_system_score_gemma":0.00018217249,"threshold_uncertainty_score":0.021222293},"labels":[],"label_agreement":null},{"id":"W2035631829","doi":"10.1242/jcs.03185","title":"HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage","year":2006,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Western University","funders":"","keywords":"Mef2; Biology; MEF2C; GATA4; Histone deacetylase 5; Cell biology; Myogenic regulatory factors; HDAC4; P19 cell; Downregulation and upregulation; Myocyte; Trichostatin A; Cellular differentiation; Wortmannin; Molecular biology; Histone deacetylase; Gene expression; Histone; Signal transduction; Enhancer; MyoD; Genetics; Adult stem cell; PI3K/AKT/mTOR pathway; Gene","score_opus":0.004256814970401758,"score_gpt":0.2450346195263599,"score_spread":0.24077780455595815,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035631829","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97654474,0.0074872877,0.0056475713,0.00014000553,0.00008047098,0.000037848804,0.0009207848,0.00014013349,0.009001147],"genre_scores_gemma":[0.98930746,0.0037103607,0.0018494057,0.00004083555,0.00002344452,0.000021753096,0.0008519725,0.000025288095,0.0041694352],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999181,0.000009751172,0.0000056851995,0.000021851412,0.000017880942,0.000026633483],"domain_scores_gemma":[0.99996495,0.0000050235826,0.000008925832,0.0000034253806,0.000005891367,0.0000117674],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006849599,0.0003472612,0.00017442304,0.00016303726,0.0001547523,0.00029321568,0.00012645336,0.00014998663,0.0015655837],"category_scores_gemma":[0.000060139624,0.00012489084,0.00020200593,0.0001376931,0.00018594843,0.00014041796,0.00013257729,0.0002911268,0.00053546095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00004097009,0.0000068816016,0.00020592482,0.000018590961,0.0000025789425,0.00001889666,0.000003670464,0.000012033702,0.9987311,0.0000692258,0.000024202734,0.00086587237],"study_design_scores_gemma":[0.000011115972,0.000073483265,0.008032021,0.0000036125773,0.000012012722,0.000077524215,0.0000129013215,0.00028810496,0.98884356,0.000033228942,0.0026106997,0.0000018483983],"about_ca_topic_score_codex":0.00075854134,"about_ca_topic_score_gemma":0.0013604091,"teacher_disagreement_score":0.0015655837,"about_ca_system_score_codex":0.00034186442,"about_ca_system_score_gemma":0.00024062797,"threshold_uncertainty_score":0.0052374005},"labels":[],"label_agreement":null},{"id":"W2036131882","doi":"10.1016/s0167-4781(00)00191-3","title":"Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)","year":2000,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Connaught Fund; Hospital for Sick Children; University of Washington","keywords":"Biology; Exon; Histone deacetylase 5; SAP30; Molecular biology; Genetics; Histone deacetylase; Gene; Histone","score_opus":0.004618565292420356,"score_gpt":0.24585222251398647,"score_spread":0.24123365722156612,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036131882","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97479135,0.006480348,0.008949244,0.000320783,0.000035552323,0.000027079352,0.0021881594,0.00014756982,0.0070599667],"genre_scores_gemma":[0.98909783,0.00078044523,0.0024013594,0.000082946026,0.000009299225,0.000009302897,0.0029921562,0.000019878933,0.0046067135],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993193,0.000004990069,0.000004385231,0.00003085444,0.0000136469,0.000014165894],"domain_scores_gemma":[0.99987113,0.000029441124,0.000037549515,0.000018579516,0.000016090888,0.000027154734],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000044885386,0.00014286522,0.00011989512,0.00054915407,0.00028342416,0.00027228697,0.00021346542,0.00025865049,0.0028815288],"category_scores_gemma":[0.00014858069,0.00018691778,0.0002649351,0.00036389852,0.00024630892,0.00018710751,0.00023887857,0.00027414662,0.0010737823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00045179913,0.000042308413,0.004548095,0.00009033966,0.000027268003,0.00020965937,0.00008089597,0.00028344008,0.9810751,0.0015487217,0.00021690152,0.011425592],"study_design_scores_gemma":[0.00009085534,0.0005942991,0.39775452,0.000060972212,0.00014256958,0.0014745072,0.00046941813,0.0020343384,0.5652367,0.0012405025,0.030872926,0.000028397197],"about_ca_topic_score_codex":0.006350393,"about_ca_topic_score_gemma":0.0064459126,"teacher_disagreement_score":0.006350393,"about_ca_system_score_codex":0.00046248696,"about_ca_system_score_gemma":0.00025078596,"threshold_uncertainty_score":0.012626886},"labels":[],"label_agreement":null},{"id":"W2036723718","doi":"10.1016/j.exphem.2012.06.001","title":"Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines","year":2012,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Cancer Foundation","funders":"National Cancer Institute; National Institutes of Health","keywords":"Cytotoxicity; Cancer research; Epigenetics; Histone deacetylase; Histone deacetylase inhibitor; Biology; Cell growth; Chemistry; Molecular biology; Pharmacology; Histone; Biochemistry; DNA; In vitro","score_opus":0.020100419899292225,"score_gpt":0.3197646947464343,"score_spread":0.2996642748471421,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036723718","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9949898,0.0013703039,0.0010394176,0.000056453144,0.00003306893,0.00005123531,0.0001824253,0.00007401218,0.002203162],"genre_scores_gemma":[0.9971276,0.0005118452,0.00069943164,0.000020321455,0.000012352886,0.000033226053,0.0002016013,0.00001036573,0.0013832097],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997918,0.000049599348,0.000020198742,0.0000258786,0.00006510398,0.0000475004],"domain_scores_gemma":[0.99981207,0.00006400553,0.000027980273,0.000035562767,0.00002353487,0.000036904064],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024052634,0.0003319359,0.00043875477,0.000392591,0.00018438698,0.00030435406,0.000314168,0.000274372,0.002759052],"category_scores_gemma":[0.00023682258,0.00017198775,0.00027906641,0.00028220675,0.00019902023,0.00021504372,0.00028589222,0.00065563945,0.0003625949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008244823,0.00031597723,0.00059597654,0.000055879882,0.00003202339,0.00006586024,0.000038420556,0.00038132927,0.9904755,0.00023281066,0.00015338731,0.0068283635],"study_design_scores_gemma":[0.000059856164,0.0014027212,0.0029542197,0.0000052758064,0.000056905017,0.00013092166,0.000024345274,0.0005708395,0.9930046,0.000031013282,0.0017557918,0.0000034305647],"about_ca_topic_score_codex":0.000651778,"about_ca_topic_score_gemma":0.002287861,"teacher_disagreement_score":0.002759052,"about_ca_system_score_codex":0.00026214434,"about_ca_system_score_gemma":0.00029948982,"threshold_uncertainty_score":0.009229898},"labels":[],"label_agreement":null},{"id":"W2037231878","doi":"10.1074/jbc.c100034200","title":"Biochemical Analysis of Transcriptional Repression byDrosophila Histone Deacetylase 1","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Psychological repression; Histone deacetylase; HDAC11; Histone; Histone deacetylase 2; Histone deacetylase 5; HDAC10; Cell biology; Chemistry; Genetics; Biology; Gene expression; Gene","score_opus":0.026343771362083983,"score_gpt":0.31586359393982344,"score_spread":0.28951982257773945,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2037231878","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9819389,0.0054149977,0.00820617,0.00019401064,0.000047539004,0.00004037593,0.0016583711,0.00011053824,0.0023890727],"genre_scores_gemma":[0.98159987,0.0026891255,0.0059227063,0.00007539282,0.000017195101,0.00003021088,0.0058605946,0.000043637054,0.0037613316],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999887,0.000018394248,0.000010418552,0.00002528129,0.000033781707,0.000025257576],"domain_scores_gemma":[0.999877,0.000024366851,0.000031269014,0.000015189995,0.000025413578,0.000026782202],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014320714,0.0004535725,0.00024445343,0.00018004225,0.00014219993,0.0003224565,0.00029101275,0.00017364544,0.0008479293],"category_scores_gemma":[0.0001719561,0.00015595782,0.00028998332,0.00021732486,0.0001369197,0.00013158371,0.00011241908,0.0004242035,0.00049731537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000020585558,0.000008265312,0.00016231067,0.00002446823,0.000004273772,0.0000143124835,0.0000055589626,0.0000501965,0.9993599,0.00004870374,0.000010813999,0.00029060748],"study_design_scores_gemma":[0.00000541269,0.00006410358,0.0033400839,0.000004490364,0.000011187601,0.000073718766,0.0000153187,0.0009811043,0.9932433,0.000030182047,0.0022266067,0.000004500477],"about_ca_topic_score_codex":0.0017487037,"about_ca_topic_score_gemma":0.002825939,"teacher_disagreement_score":0.0017487037,"about_ca_system_score_codex":0.0006641722,"about_ca_system_score_gemma":0.00022705246,"threshold_uncertainty_score":0.004818976},"labels":[],"label_agreement":null},{"id":"W2037793441","doi":"10.1126/scisignal.2000576","title":"Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"HDAC6; Acetylation; Cell biology; Epidermal growth factor receptor; Histone deacetylase; Biology; HDAC4; Growth factor receptor; Receptor; Chemistry; Biochemistry; Signal transduction; Histone; Histone methyltransferase","score_opus":0.012399244787001931,"score_gpt":0.2809492914686546,"score_spread":0.26855004668165267,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2037793441","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9916893,0.0026630515,0.003539759,0.000100953905,0.00003527812,0.0000116521305,0.00032580798,0.00007947355,0.0015548397],"genre_scores_gemma":[0.99597675,0.0010665625,0.0014316445,0.00002770225,0.000006092235,0.00000451325,0.00026513948,0.000010979961,0.0012106922],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993575,0.000008945922,0.000004577394,0.000017193994,0.000017805738,0.000015784475],"domain_scores_gemma":[0.999956,0.0000067916885,0.000013313634,0.0000052793484,0.00000838836,0.000010171058],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008926452,0.0002011656,0.00015544012,0.0001155622,0.00010499846,0.00028592383,0.00014618435,0.00009925575,0.0007988072],"category_scores_gemma":[0.00010043118,0.00009642498,0.00019666736,0.000085854226,0.00011997986,0.000120704884,0.00011301787,0.0002026072,0.00034752104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014943873,0.000010995768,0.0014215943,0.000026424661,0.000010013728,0.000035822053,0.0000068223253,0.00008987833,0.9946293,0.00011791625,0.00006725397,0.0034346431],"study_design_scores_gemma":[0.000019480483,0.00012037358,0.021133987,0.0000033979538,0.00001949258,0.00020833312,0.000025783758,0.0022179706,0.9734867,0.00010695268,0.0026531082,0.000004433357],"about_ca_topic_score_codex":0.0005356304,"about_ca_topic_score_gemma":0.0012965797,"teacher_disagreement_score":0.0007988072,"about_ca_system_score_codex":0.0002053475,"about_ca_system_score_gemma":0.00010147209,"threshold_uncertainty_score":0.0026723146},"labels":[],"label_agreement":null},{"id":"W2038246587","doi":"10.1186/1756-9966-28-71","title":"Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells","year":2009,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Shandong Academy of Medical Sciences; McGill University","keywords":"Cancer research; Transfection; Apoptosis; Metastasis; Programmed cell death; Cell; Cell growth; Metastasis Suppressor Gene; Cell culture; Matrigel; Biology; Medicine; Cancer; Internal medicine; Angiogenesis","score_opus":0.1030618333156946,"score_gpt":0.4727203987447856,"score_spread":0.36965856542909103,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2038246587","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9927045,0.0024745762,0.0028377369,0.00012768037,0.00004739413,0.0000387027,0.00021991324,0.00011931245,0.0014303055],"genre_scores_gemma":[0.99511284,0.00095816806,0.0012744027,0.000041857085,0.000010924802,0.00005414979,0.00047816703,0.0000096558,0.0020598134],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999368,0.000009892408,0.000005926934,0.000009523965,0.000020671849,0.000017230352],"domain_scores_gemma":[0.9999558,0.000010303146,0.000007899515,0.000005450169,0.000009495316,0.000011121122],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000098229044,0.00024075418,0.00024904154,0.00027120218,0.00015675036,0.00014647108,0.00012376094,0.0001439518,0.00097547396],"category_scores_gemma":[0.00009924042,0.00007405498,0.00017720344,0.00018698319,0.00014575815,0.00009640559,0.00014346682,0.00036741229,0.0002011399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030042802,0.00015328813,0.0012695477,0.00012413545,0.000012281513,0.00008628224,0.00001898414,0.00020872669,0.99212295,0.0001814658,0.0002340028,0.0052879867],"study_design_scores_gemma":[0.0000971838,0.0009978177,0.0064416276,0.0000070191218,0.000032763906,0.00042207775,0.000028570812,0.0023974646,0.98469216,0.00009539184,0.00478277,0.000005270653],"about_ca_topic_score_codex":0.00041553736,"about_ca_topic_score_gemma":0.00037942038,"teacher_disagreement_score":0.00097547396,"about_ca_system_score_codex":0.00024074731,"about_ca_system_score_gemma":0.00028240998,"threshold_uncertainty_score":0.003263235},"labels":[],"label_agreement":null},{"id":"W2040144233","doi":"10.1186/1475-2867-11-29","title":"The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells","year":2011,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Cancer Care Ontario; University of Ottawa","keywords":"Histone deacetylase; Histone deacetylase inhibitor; Cancer research; Ovarian cancer; Medicine; HDAC11; Breast cancer; Histone deacetylase 2; Histone deacetylase 5; HDAC1; Histone; Cancer; Oncology; Internal medicine; Biology; Genetics; Gene","score_opus":0.008155905287925374,"score_gpt":0.2741547817743703,"score_spread":0.26599887648644494,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040144233","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9948715,0.0028222518,0.0005990716,0.00011465826,0.00003114706,0.0000220715,0.00033418645,0.000041979918,0.0011630898],"genre_scores_gemma":[0.99590826,0.0014714006,0.0008728201,0.000046905567,0.0000090857775,0.000021940088,0.0004952243,0.0000055442338,0.0011688425],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993396,0.00001159881,0.0000070657743,0.000011553281,0.000019568559,0.000016280172],"domain_scores_gemma":[0.9999393,0.000016291304,0.0000152157945,0.0000076503475,0.000011114451,0.000010396566],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010074752,0.00021416713,0.00017287953,0.00014923014,0.0001259029,0.00012829511,0.00015425053,0.00017499577,0.001591488],"category_scores_gemma":[0.00010419494,0.00009351786,0.00019941363,0.00016663055,0.00010725011,0.00009545687,0.00011380398,0.00032730988,0.00023183203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004920115,0.00009175833,0.00063673296,0.000100594,0.000013091115,0.00005436911,0.000019417395,0.00013090148,0.9941248,0.00004701791,0.00013308402,0.004156212],"study_design_scores_gemma":[0.000029656343,0.0009959537,0.0055216034,0.0000062155123,0.000024623188,0.00019500169,0.000027059223,0.00037731364,0.9907941,0.000020002155,0.0020050257,0.0000034709972],"about_ca_topic_score_codex":0.0008210306,"about_ca_topic_score_gemma":0.0011145873,"teacher_disagreement_score":0.001591488,"about_ca_system_score_codex":0.00021326644,"about_ca_system_score_gemma":0.000205343,"threshold_uncertainty_score":0.005324006},"labels":[],"label_agreement":null},{"id":"W2040255124","doi":"10.1371/journal.pone.0020987","title":"Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Vorinostat; DNA damage; Histone deacetylase inhibitor; Myeloid leukemia; Apoptosis; Histone deacetylase; Cancer research; Chemistry; Histone; Biology; DNA; Biochemistry","score_opus":0.04177956896412779,"score_gpt":0.23776382752385433,"score_spread":0.19598425855972654,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040255124","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900567,0.0037411212,0.0023570058,0.00020125549,0.000060847804,0.00007273756,0.00047690925,0.00017467912,0.0028587019],"genre_scores_gemma":[0.9940637,0.0015696796,0.0012216088,0.00011689183,0.000024082894,0.000062448584,0.00080202747,0.000013466086,0.002126099],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988925,0.000024331483,0.000012373899,0.000017567243,0.00003678737,0.000019664456],"domain_scores_gemma":[0.9999205,0.000018887074,0.000020916259,0.000014362199,0.000011937767,0.000013457983],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000989924,0.00028677314,0.00035091516,0.00028092734,0.00015892493,0.00019604409,0.0001372355,0.00024126226,0.0020449609],"category_scores_gemma":[0.00011423987,0.00011413174,0.00021428068,0.00022362737,0.00014131295,0.00013669246,0.00013241304,0.00043541237,0.00040656864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025783843,0.000060284365,0.00014179849,0.000057474663,0.000009979992,0.00011245355,0.000025348432,0.0000705417,0.9968413,0.00007259252,0.0000975921,0.0022527245],"study_design_scores_gemma":[0.00006235357,0.0008093024,0.0037872174,0.000006311502,0.000015413909,0.00027769245,0.000028525556,0.00061802403,0.9913952,0.00009871759,0.002897813,0.0000034192735],"about_ca_topic_score_codex":0.00036355748,"about_ca_topic_score_gemma":0.00060502527,"teacher_disagreement_score":0.0020449609,"about_ca_system_score_codex":0.00021190435,"about_ca_system_score_gemma":0.0001345416,"threshold_uncertainty_score":0.006841004},"labels":[],"label_agreement":null},{"id":"W2040481717","doi":"10.1371/journal.pone.0074384","title":"Inhibition of RUNX2 Transcriptional Activity Blocks the Proliferation, Migration and Invasion of Epithelial Ovarian Carcinoma Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Cancer Research Society","keywords":"Cancer research; Carcinogenesis; Biology; Gene knockdown; Ovarian cancer; Metastasis; Serous fluid; DNA methylation; Epigenetics; Gene expression; Cancer; Gene; Genetics","score_opus":0.02205432024012966,"score_gpt":0.217566915341058,"score_spread":0.19551259510092833,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040481717","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99013686,0.0031390588,0.0021920183,0.000151318,0.00006178256,0.000047312587,0.0005665273,0.0001264765,0.0035786445],"genre_scores_gemma":[0.9911412,0.0019430905,0.0012216201,0.00004206416,0.000012283315,0.00005766803,0.0008288855,0.000018639405,0.0047345296],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999915,0.000012431039,0.000006418974,0.000014522993,0.000029511148,0.000022080852],"domain_scores_gemma":[0.9999691,0.0000067815386,0.0000060240945,0.000005147131,0.000004257443,0.000008630763],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010813707,0.000300074,0.00022348326,0.00016412284,0.00011584873,0.00017311427,0.00012880554,0.00011351557,0.0012881682],"category_scores_gemma":[0.00007565401,0.0000874351,0.00019798134,0.00018177478,0.00012600787,0.00009268926,0.00011415917,0.0003630584,0.00024499826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001845134,0.000052433978,0.0001858173,0.00004761373,0.0000070834426,0.00003656023,0.00001841582,0.00010350629,0.996709,0.00011456391,0.00011151532,0.002428986],"study_design_scores_gemma":[0.000045855668,0.0005558514,0.0035705161,0.000004496108,0.000020675272,0.00010076107,0.000028672328,0.0011148322,0.9880702,0.000049386563,0.0064356043,0.0000031878774],"about_ca_topic_score_codex":0.00084880996,"about_ca_topic_score_gemma":0.0019400109,"teacher_disagreement_score":0.0012881682,"about_ca_system_score_codex":0.00017287328,"about_ca_system_score_gemma":0.00029161127,"threshold_uncertainty_score":0.004309356},"labels":[],"label_agreement":null},{"id":"W2040852160","doi":"10.1111/bjh.13016","title":"A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome","year":2014,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital","funders":"Merck","keywords":"Decitabine; Vorinostat; Medicine; Tolerability; Myelodysplastic syndromes; Internal medicine; Oncology; Refractory (planetary science); Myeloid leukemia; Pharmacology; Adverse effect; Histone deacetylase; Bone marrow; Biology","score_opus":0.012352795511653919,"score_gpt":0.3094381602760078,"score_spread":0.2970853647643539,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040852160","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9951336,0.0012733206,0.00034543753,0.00026680873,0.000052716376,0.0016037559,0.00034445623,0.00003993646,0.0009400566],"genre_scores_gemma":[0.9908915,0.0013398284,0.0017945658,0.0004391876,0.000101399986,0.0023256675,0.0012916223,0.000012962905,0.0018032612],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.9996958,0.00017939946,0.000012373215,0.000044509714,0.000021909356,0.000045993518],"domain_scores_gemma":[0.99959487,0.00009390054,0.00010868331,0.000028639412,0.000020694835,0.00015319379],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00094613223,0.0014475839,0.0013395337,0.0003703767,0.00030822787,0.00052242243,0.00050080824,0.00078462367,0.0024948022],"category_scores_gemma":[0.0008100669,0.00041654214,0.00074682175,0.00025517933,0.00062689494,0.00037951896,0.0002806358,0.0017530825,0.00035654058],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.74427384,0.0632696,0.008319191,0.0005950968,0.0008321162,0.0005261313,0.00030366002,0.0041421875,0.05843854,0.00041314168,0.0033107551,0.11557564],"study_design_scores_gemma":[0.44689238,0.5312029,0.010913606,0.000027476271,0.0002453719,0.00033944577,0.000041251922,0.0018617032,0.0057827667,0.00022144114,0.002447793,0.00002382797],"about_ca_topic_score_codex":0.00046481568,"about_ca_topic_score_gemma":0.0014080013,"teacher_disagreement_score":0.0024948022,"about_ca_system_score_codex":0.00066870585,"about_ca_system_score_gemma":0.0010464325,"threshold_uncertainty_score":0.008345962},"labels":[],"label_agreement":null},{"id":"W2041997366","doi":"10.1158/1078-0432.ccr-07-4427","title":"Evaluation of the Pharmacodynamic Effects of MGCD0103 from Preclinical Models to Human Using a Novel HDAC Enzyme Assay","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Pyrogenesis (Canada)","funders":"National Cancer Institute","keywords":"Ex vivo; In vivo; Histone deacetylase; Pharmacology; Pharmacodynamics; In vitro; Acetylation; Histone deacetylase inhibitor; Chemistry; Pharmacokinetics; Molecular biology; Cancer research; Biochemistry; Medicine; Histone; Biology","score_opus":0.4481591514104984,"score_gpt":0.5729885176329691,"score_spread":0.1248293662224707,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2041997366","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94545233,0.010881896,0.03632832,0.00043926097,0.00021548754,0.00054168986,0.0018879916,0.0008327826,0.0034202437],"genre_scores_gemma":[0.9837414,0.0031470354,0.008632269,0.00017467512,0.000055015254,0.00022458611,0.0017120899,0.00007640581,0.0022364429],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996499,0.00008330303,0.000022739492,0.00007198593,0.00013312421,0.00003892445],"domain_scores_gemma":[0.99981195,0.000039051683,0.00005891811,0.000026441034,0.000033100347,0.00003062952],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006049613,0.0008042633,0.0006940045,0.00027562026,0.00013910755,0.00043826696,0.00039412128,0.0003853466,0.0016457307],"category_scores_gemma":[0.00040495585,0.00020862155,0.00038248548,0.00030601805,0.00038027842,0.0002113277,0.00017009137,0.0011255881,0.00053020974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011115271,0.00027512657,0.0011122905,0.00009638841,0.00003780028,0.000043949945,0.000021933485,0.00040377057,0.98532975,0.000044596396,0.00028946088,0.011233281],"study_design_scores_gemma":[0.00020760091,0.008478639,0.00659348,0.0000075950798,0.00012543892,0.0003296726,0.000020374782,0.0023581937,0.97788805,0.00004416897,0.0039339527,0.0000129259015],"about_ca_topic_score_codex":0.00089399406,"about_ca_topic_score_gemma":0.00213749,"teacher_disagreement_score":0.0016457307,"about_ca_system_score_codex":0.00064468326,"about_ca_system_score_gemma":0.00047542175,"threshold_uncertainty_score":0.005505562},"labels":[],"label_agreement":null},{"id":"W2042232241","doi":"10.1074/jbc.m112.440446","title":"Protein Kinase CK2 Regulates the Dimerization of Histone Deacetylase 1 (HDAC1) and HDAC2 during Mitosis","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Histone deacetylase 2; HDAC1; Histone deacetylase 5; HDAC11; Cell biology; Chemistry; Mitosis; HDAC10; Histone; Histone deacetylase; Biochemistry; Biology; DNA","score_opus":0.010414628997671845,"score_gpt":0.2626380102042356,"score_spread":0.25222338120656373,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042232241","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9856625,0.007329803,0.0028109357,0.00015760184,0.00010894047,0.00003428003,0.00036505578,0.00010432634,0.00342651],"genre_scores_gemma":[0.99484503,0.0017451798,0.00065324735,0.000045608558,0.000021928288,0.000028631372,0.0003239062,0.000021297696,0.002315262],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989223,0.000011055806,0.000008418693,0.000029244795,0.00001882479,0.00004012571],"domain_scores_gemma":[0.9999125,0.000008030196,0.00003568488,0.0000055676087,0.00001129444,0.000026924956],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009340753,0.00048868346,0.00023947922,0.00023144267,0.00021475357,0.00041938934,0.00021867178,0.00017863374,0.001673996],"category_scores_gemma":[0.00014185742,0.00016749887,0.00020383626,0.00014083044,0.0001732046,0.00022948571,0.00028971274,0.00032481406,0.00038565474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020528222,0.000019942825,0.00078966963,0.000061794395,0.000007707739,0.000057515168,0.000014376488,0.00011892953,0.9969779,0.00014537903,0.00010704929,0.0014944344],"study_design_scores_gemma":[0.000066801,0.00012136936,0.049182855,0.000020578187,0.000049278857,0.00045975696,0.00007313379,0.0030602666,0.942013,0.00013967714,0.0047980268,0.000015227898],"about_ca_topic_score_codex":0.0009198118,"about_ca_topic_score_gemma":0.001210468,"teacher_disagreement_score":0.001673996,"about_ca_system_score_codex":0.00057455775,"about_ca_system_score_gemma":0.00023631712,"threshold_uncertainty_score":0.005600095},"labels":[],"label_agreement":null},{"id":"W2042243678","doi":"10.1016/j.bmc.2010.03.078","title":"Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"Chemistry; Histone deacetylase; Agonist; Bifunctional; Histone deacetylase inhibitor; In vivo; In vitro; Biochemistry; Pharmacology; Calcitriol receptor; Receptor; Histone; Biology","score_opus":0.005512055495734979,"score_gpt":0.26449274830463654,"score_spread":0.25898069280890157,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042243678","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8853801,0.004897816,0.046906,0.0011572425,0.0006429287,0.0004058057,0.0012839421,0.0013210383,0.058005165],"genre_scores_gemma":[0.9724262,0.0010451982,0.011186627,0.00035471967,0.000042048483,0.00024010551,0.00047935994,0.000047900536,0.014177816],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999001,0.000013954143,0.0000056699146,0.000025985575,0.000023934994,0.000030297091],"domain_scores_gemma":[0.9999596,0.000010803888,0.000009897974,0.000005374798,0.00000465426,0.000009728958],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015584275,0.00028299025,0.00019162982,0.0002828039,0.00023023039,0.0004594018,0.0006403759,0.00040776804,0.005576892],"category_scores_gemma":[0.00012061226,0.00023802074,0.00019122407,0.00018601814,0.00012077602,0.00038140916,0.000293842,0.00049387844,0.001523486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00057206885,0.00026058228,0.00027680016,0.00021396618,0.00008570217,0.00021643839,0.00007540661,0.0020672067,0.96416205,0.01165066,0.0016821417,0.018736927],"study_design_scores_gemma":[0.000112773974,0.00094448857,0.00047806615,0.000008442237,0.00006369555,0.00022155797,0.000031799776,0.0019947274,0.9684231,0.0006993013,0.02699795,0.000024011444],"about_ca_topic_score_codex":0.00024556,"about_ca_topic_score_gemma":0.0004432436,"teacher_disagreement_score":0.005576892,"about_ca_system_score_codex":0.00033133233,"about_ca_system_score_gemma":0.00014404132,"threshold_uncertainty_score":0.018656492},"labels":[],"label_agreement":null},{"id":"W2042254753","doi":"10.1074/jbc.m109.000539","title":"Protein Kinase A-regulated Assembly of a MEF2·HDAC4 Repressor Complex Controls c-Jun Expression in Vascular Smooth Muscle Cells","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital; University of Toronto; York University","funders":"Muscular Dystrophy Association","keywords":"Myocardin; Mef2; HDAC4; Biology; Cell biology; Repressor; Vascular smooth muscle; Protein kinase A; Molecular biology; Kinase; Regulation of gene expression; Transcription factor; Serum response factor; Enhancer; Biochemistry; Histone methyltransferase; Gene; Endocrinology","score_opus":0.02078182883524734,"score_gpt":0.2797347327892596,"score_spread":0.25895290395401227,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042254753","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98914087,0.001790836,0.0054883286,0.00012196773,0.00008430052,0.000033801778,0.00065693486,0.00018344168,0.0024995506],"genre_scores_gemma":[0.98880696,0.0005904545,0.0033988825,0.0000663616,0.000024464927,0.0000623516,0.001141954,0.0000582766,0.0058503402],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978715,0.000026723948,0.000019403133,0.00006423128,0.000045512497,0.0000569202],"domain_scores_gemma":[0.9998869,0.000013598827,0.00002885061,0.00001696027,0.000017023858,0.000036716276],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020242704,0.00040022438,0.00022398711,0.00032200335,0.0003907355,0.00047952047,0.00031014445,0.00024260217,0.0016073381],"category_scores_gemma":[0.00014121624,0.00028467993,0.00039050594,0.0001867943,0.0003354734,0.00019114222,0.00033822682,0.0005959532,0.00086837355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000673514,0.000014187601,0.00016355101,0.000013820367,0.0000036346746,0.00001211028,0.000008258816,0.000022292277,0.99928135,0.00006606861,0.000034198365,0.0003132195],"study_design_scores_gemma":[0.000034744455,0.00009631442,0.014301159,0.0000059374297,0.000014781229,0.000089850204,0.000034542754,0.0022015,0.98,0.000055962602,0.0031586895,0.0000064111005],"about_ca_topic_score_codex":0.0017143037,"about_ca_topic_score_gemma":0.0025225505,"teacher_disagreement_score":0.0017143037,"about_ca_system_score_codex":0.0008063917,"about_ca_system_score_gemma":0.00033499737,"threshold_uncertainty_score":0.005850792},"labels":[],"label_agreement":null},{"id":"W2042828682","doi":"10.1021/jm701079h","title":"Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"Pfizer","keywords":"Pharmacophore; Chemistry; Benzamide; Histone deacetylase; Enzyme; Potency; Selectivity; Structure–activity relationship; Hydroxamic acid; Biochemistry; Aryl; Combinatorial chemistry; Enzyme inhibitor; Stereochemistry; Pharmacology; In vitro; Histone; Catalysis; Alkyl; DNA; Organic chemistry","score_opus":0.007248053431698478,"score_gpt":0.2800483031724263,"score_spread":0.2728002497407278,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042828682","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9113766,0.018952351,0.032940548,0.0007204368,0.0003918561,0.0004144904,0.0011743798,0.0009050627,0.033124268],"genre_scores_gemma":[0.95417875,0.009912761,0.019651752,0.00045740462,0.00017208826,0.00013517168,0.0010995666,0.00007050367,0.01432195],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988234,0.00001927392,0.000008594187,0.000018926816,0.00002780502,0.000043074826],"domain_scores_gemma":[0.9999517,0.0000069627254,0.000010763356,0.000004124153,0.000009680291,0.000016821914],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027283948,0.00046033334,0.00050853105,0.00023309652,0.00011443448,0.00027275234,0.0004886488,0.0002217003,0.0021853673],"category_scores_gemma":[0.00012501715,0.00017352097,0.00019186237,0.00022060762,0.00016686664,0.0002371957,0.00020078254,0.00061508775,0.00080813095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00065878854,0.0002482301,0.0002783616,0.00020808514,0.000026101403,0.00025238836,0.000048832342,0.0010132913,0.95443124,0.0018652551,0.001037711,0.039931808],"study_design_scores_gemma":[0.0012604193,0.0053524105,0.0042180247,0.000031520955,0.000116263574,0.0016013334,0.000028563818,0.005345325,0.93993795,0.0004264852,0.041628707,0.000052824173],"about_ca_topic_score_codex":0.0007120299,"about_ca_topic_score_gemma":0.0031258066,"teacher_disagreement_score":0.0021853673,"about_ca_system_score_codex":0.00036989505,"about_ca_system_score_gemma":0.00025461672,"threshold_uncertainty_score":0.0073108077},"labels":[],"label_agreement":null},{"id":"W2043212130","doi":"10.1007/s12311-013-0459-x","title":"The Expression of HDAC1 and HDAC2 During Cerebellar Cortical Development","year":2013,"lang":"en","type":"article","venue":"The Cerebellum","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Histone deacetylase 2; Biology; HDAC1; Mef2; Epigenetics; Cell biology; Neuroscience; Cellular differentiation; Histone; Epigenetic regulation of neurogenesis; Cerebellum; Gene expression; Regulation of gene expression; Histone deacetylase; DNA methylation; Gene; Genetics; Enhancer","score_opus":0.005888023749749051,"score_gpt":0.2224498733211991,"score_spread":0.21656184957145003,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2043212130","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97184104,0.012882587,0.006131586,0.00023886349,0.00006596846,0.000016123186,0.0007557017,0.00011038202,0.007957839],"genre_scores_gemma":[0.98745805,0.0023381598,0.0014104532,0.00006254669,0.000016427304,0.000018506264,0.0005129674,0.00004772057,0.008135052],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998398,0.000012620733,0.000011196022,0.00004404838,0.00004262094,0.000049688704],"domain_scores_gemma":[0.999843,0.000021103713,0.000045742843,0.000011322049,0.000033100172,0.000045592107],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018923685,0.00030707134,0.00030774248,0.0005609537,0.00034207405,0.0009127033,0.0003016887,0.00028501803,0.0011932026],"category_scores_gemma":[0.00028570255,0.0003981089,0.00026847594,0.00033155698,0.00047429875,0.00062783726,0.0003061199,0.0006559169,0.00028860866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044073712,0.000011016925,0.00242121,0.000054746095,0.000018053397,0.00012674196,0.000065259956,0.00008534962,0.99153954,0.00087426923,0.00008655753,0.0042764377],"study_design_scores_gemma":[0.000023466479,0.00013047611,0.084452085,0.000019940106,0.0000576091,0.00039706973,0.00018850282,0.000717083,0.9087575,0.000316167,0.0049270904,0.00001294213],"about_ca_topic_score_codex":0.0071085473,"about_ca_topic_score_gemma":0.016285762,"teacher_disagreement_score":0.0071085473,"about_ca_system_score_codex":0.0013463169,"about_ca_system_score_gemma":0.0006524545,"threshold_uncertainty_score":0.014134347},"labels":[],"label_agreement":null},{"id":"W2043712123","doi":"10.1002/jcb.21746","title":"Histone deacetylases as transducers and targets of nuclear signaling","year":2008,"lang":"en","type":"review","venue":"Journal of Cellular Biochemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Histone; Crosstalk; Histone deacetylase; Acetylation; Chromatin; HDAC10; Cell biology; HDAC11; Histone deacetylase 5; Lysine; Biology; Chemistry; Biochemistry; Physics; DNA; Amino acid; Gene","score_opus":0.01650143306024958,"score_gpt":0.3101552519111812,"score_spread":0.2936538188509316,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2043712123","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00017553277,0.99747247,0.00027806405,0.00027270036,0.00040090666,0.000005765875,0.000014602843,0.000013517896,0.0013664231],"genre_scores_gemma":[0.00095479697,0.99705195,0.00027510241,0.00022588644,0.00027932462,0.000008274267,0.000029698796,0.0000016278447,0.0011732633],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998135,0.000026410884,0.00002298266,0.00004061405,0.00007350216,0.000023011302],"domain_scores_gemma":[0.9998252,0.000055349756,0.000027460832,0.000010188929,0.00005477659,0.000027107999],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006227084,0.0010467252,0.0014011747,0.0019160177,0.00031983416,0.0010896953,0.0014300436,0.0011446538,0.0029532153],"category_scores_gemma":[0.00041326488,0.00041974615,0.0003468402,0.00209809,0.0007579846,0.0016335633,0.0007671582,0.002414678,0.004851426],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014096277,0.0000958253,0.0001935752,0.0067892177,0.00008160868,0.00039319257,0.000075074684,0.0005940981,0.012678626,0.012164158,0.03519123,0.9316025],"study_design_scores_gemma":[0.00002769418,0.00006236125,0.0005318401,0.00073071336,0.000043559256,0.00093850156,0.000038905877,0.0000852909,0.0016593033,0.003142623,0.99272364,0.000015577978],"about_ca_topic_score_codex":0.0005985427,"about_ca_topic_score_gemma":0.0011969802,"teacher_disagreement_score":0.0029532153,"about_ca_system_score_codex":0.00094387284,"about_ca_system_score_gemma":0.0006872005,"threshold_uncertainty_score":0.00987947},"labels":[],"label_agreement":null},{"id":"W2044699816","doi":"10.1016/j.bmcl.2009.02.075","title":"Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Sulfamide; HDAC1; Chemistry; Lysine; HDAC6; Histone deacetylase; Enzyme; Biochemistry; Metabolic stability; Potency; HDAC8; Hydroxamic acid; Pharmacology; Stereochemistry; Histone; Amino acid; In vitro; Organic chemistry","score_opus":0.013482165707554136,"score_gpt":0.2914858391354335,"score_spread":0.2780036734278794,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044699816","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95593894,0.0112473685,0.01390504,0.00030858375,0.00018751496,0.00042741158,0.00091164006,0.00019797427,0.016875606],"genre_scores_gemma":[0.9800091,0.008191999,0.006078503,0.00009489102,0.000042115942,0.00008469938,0.00061190303,0.000024913423,0.0048618405],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998735,0.000026550993,0.000014073987,0.000015561602,0.00003085187,0.000039395618],"domain_scores_gemma":[0.9999136,0.000011875029,0.0000165732,0.000009736372,0.000024441055,0.000023818502],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042103455,0.00047633034,0.00033116306,0.0003374305,0.0002251208,0.00021358412,0.00039302444,0.00028433572,0.0018092257],"category_scores_gemma":[0.00021844149,0.00015541434,0.0002914142,0.00025163888,0.00019359472,0.00030132165,0.00020980567,0.00033191213,0.0004021048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009150721,0.0005039714,0.0003966022,0.000455819,0.00006724556,0.0005381253,0.00015899188,0.0032724116,0.95680285,0.0018215252,0.0007706404,0.0342967],"study_design_scores_gemma":[0.00023365044,0.0048418622,0.0010234612,0.000026753036,0.00007740215,0.0002841041,0.000042048316,0.0011170639,0.9771131,0.00016178073,0.015059461,0.00001924475],"about_ca_topic_score_codex":0.0006746125,"about_ca_topic_score_gemma":0.0012996813,"teacher_disagreement_score":0.0018092257,"about_ca_system_score_codex":0.00031181335,"about_ca_system_score_gemma":0.00033493605,"threshold_uncertainty_score":0.006052494},"labels":[],"label_agreement":null},{"id":"W2046137645","doi":"10.1074/jbc.c200378200","title":"The Transcriptional Repressor Sp3 Is Associated with CK2-phosphorylated Histone Deacetylase 2","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University; Research Manitoba","funders":"","keywords":"Histone deacetylase 2; Histone deacetylase; Sp1 transcription factor; Histone deacetylase 5; Cancer research; Chemistry; Biology; Molecular biology; Histone; Promoter; Gene expression; Biochemistry; Gene","score_opus":0.02521738375335255,"score_gpt":0.265840221267618,"score_spread":0.24062283751426547,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2046137645","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95833784,0.0106595205,0.020163443,0.00051893655,0.00030197346,0.0000897821,0.0018395267,0.00068462564,0.0074044396],"genre_scores_gemma":[0.9831131,0.0017973651,0.003509123,0.00014193446,0.00006509441,0.000052466647,0.0034035065,0.000090448106,0.007827094],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997683,0.000018018536,0.000015218604,0.00007771877,0.000063789215,0.00005690111],"domain_scores_gemma":[0.9998216,0.000011860378,0.00006782423,0.000017344988,0.000028100047,0.000053272517],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013221824,0.0005161748,0.00026225482,0.00033397376,0.00035589043,0.00037217245,0.00042439156,0.0002737535,0.0035526475],"category_scores_gemma":[0.00019471768,0.00028017303,0.0005074208,0.00035637285,0.00022208091,0.00018970332,0.00045937332,0.0006242111,0.0017903518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002045559,0.000023227492,0.000964602,0.000089936344,0.00001928433,0.00021695266,0.000014945226,0.00006665996,0.99442685,0.00024187105,0.00044488165,0.0032861836],"study_design_scores_gemma":[0.000080426355,0.00017645326,0.039317172,0.0000204492,0.000054153294,0.0037250442,0.000041598298,0.0036163912,0.9263006,0.00048030616,0.02616659,0.000020835985],"about_ca_topic_score_codex":0.001055917,"about_ca_topic_score_gemma":0.00096221396,"teacher_disagreement_score":0.0035526475,"about_ca_system_score_codex":0.0006386869,"about_ca_system_score_gemma":0.00028501885,"threshold_uncertainty_score":0.011884809},"labels":[],"label_agreement":null},{"id":"W2046305562","doi":"10.1016/j.bcmd.2009.03.001","title":"‘Runxs and regulations’ of sensory and motor neuron subtype differentiation: Implications for hematopoietic development","year":2009,"lang":"en","type":"review","venue":"Blood Cells Molecules and Diseases","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke","keywords":"Biology; Transcription factor; Haematopoiesis; Nervous system; Neuroscience; Phenotype; Sensory system; Cell biology; Genetics; Gene; Stem cell","score_opus":0.022387348130267815,"score_gpt":0.292900319462479,"score_spread":0.2705129713322112,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2046305562","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00018669866,0.99685127,0.00043631074,0.0006864079,0.00072189723,0.0000037099903,0.00002361586,0.000011662958,0.0010785497],"genre_scores_gemma":[0.0011699469,0.99565965,0.0005482492,0.0005615201,0.00066070864,0.0000073146084,0.00005183835,0.0000034809143,0.0013372195],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998154,0.000028853996,0.000029782415,0.00004921983,0.000056817837,0.000019865969],"domain_scores_gemma":[0.99978024,0.00010478903,0.000029705461,0.000011262155,0.00005295844,0.000021188074],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009255414,0.00088548375,0.0014022118,0.0009856899,0.00026221658,0.001026654,0.001435716,0.0015279548,0.0023668264],"category_scores_gemma":[0.00063095475,0.0004191192,0.00042373163,0.0015388055,0.0012301736,0.0016340355,0.00079465576,0.0022272216,0.0017014367],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023117305,0.000047264275,0.00031712087,0.0069076545,0.00011896059,0.00046468657,0.0000935309,0.00056074566,0.008999189,0.016850345,0.05544309,0.9099663],"study_design_scores_gemma":[0.000026790245,0.00003442147,0.00051636173,0.00048024504,0.000049214545,0.00067344954,0.00004701395,0.000056565324,0.0009597063,0.0034408544,0.9936998,0.000015613263],"about_ca_topic_score_codex":0.0010159352,"about_ca_topic_score_gemma":0.0025145295,"teacher_disagreement_score":0.0023668264,"about_ca_system_score_codex":0.0008626604,"about_ca_system_score_gemma":0.0009708571,"threshold_uncertainty_score":0.007917881},"labels":[],"label_agreement":null},{"id":"W2047770089","doi":"10.1007/s10495-011-0617-x","title":"HDAC inhibitors potentiate the apoptotic effect of enzastaurin in lymphoma cells","year":2011,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Cancer Research","funders":"Eli Lilly and Company","keywords":"Apoptosis; Histone deacetylase; Vorinostat; Cancer research; Lymphoma; Cell culture; Chemistry; Pharmacology; Biology; Biochemistry; Immunology; Histone","score_opus":0.009317079657537754,"score_gpt":0.23112120429728134,"score_spread":0.22180412463974358,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2047770089","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98961186,0.0046059988,0.001107322,0.00020188211,0.00008838125,0.00004553931,0.00046211958,0.00017734006,0.003699623],"genre_scores_gemma":[0.9929664,0.0027825397,0.0006659162,0.000056719808,0.000030668885,0.00003420353,0.00068201486,0.000016118438,0.0027654972],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998411,0.000032811437,0.000015832475,0.000012787592,0.00003554125,0.00006185767],"domain_scores_gemma":[0.9998807,0.000029165802,0.000020562116,0.000023083097,0.0000140561815,0.000032435866],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017617072,0.00047726618,0.0005700845,0.00040560355,0.00022588925,0.00037427217,0.00031522286,0.00025244558,0.0027058008],"category_scores_gemma":[0.00016212044,0.00017613043,0.00035635606,0.00034310055,0.00024661652,0.0002904858,0.00022921366,0.001110212,0.00057958683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0020852624,0.00044573925,0.0007478405,0.00014951028,0.000057644917,0.00020096982,0.000044762615,0.0003408759,0.9843501,0.00029566835,0.00042989937,0.010851684],"study_design_scores_gemma":[0.00020195995,0.0016418938,0.0065940972,0.00001152017,0.00005931544,0.00031500615,0.000051392944,0.00064501225,0.9861384,0.000073755284,0.0042609214,0.0000066232483],"about_ca_topic_score_codex":0.0010351785,"about_ca_topic_score_gemma":0.0032591731,"teacher_disagreement_score":0.0027058008,"about_ca_system_score_codex":0.00039474678,"about_ca_system_score_gemma":0.00039543078,"threshold_uncertainty_score":0.009051859},"labels":[],"label_agreement":null},{"id":"W2048379863","doi":"10.3892/mmr.2014.2949","title":"Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells","year":2014,"lang":"en","type":"article","venue":"Molecular Medicine Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":true,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Division of Chemistry; Office of the Higher Education Commission; National Research Foundation","keywords":"Etoposide; Trichostatin A; A549 cell; Cancer research; Downregulation and upregulation; Clusterin; HDAC4; Apoptosis; Biology; Lung cancer; Cancer cell; Multiple drug resistance; Arsenic trioxide; Histone deacetylase; Cancer; Medicine; Drug resistance; Chemotherapy; Internal medicine; Histone; Biochemistry; Microbiology; Genetics; Gene","score_opus":0.007315611291587334,"score_gpt":0.31675210397455333,"score_spread":0.309436492682966,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2048379863","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99448496,0.0018376261,0.0012554902,0.00015839227,0.00004707417,0.00003187185,0.0008471476,0.00007970391,0.0012577606],"genre_scores_gemma":[0.99355525,0.0010127416,0.0011912653,0.00007532662,0.000011492704,0.000042113963,0.0015183592,0.000012085511,0.002581388],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998159,0.000023874369,0.00002981204,0.000037306836,0.000053310123,0.0000399207],"domain_scores_gemma":[0.99993145,0.000011676558,0.000020392323,0.000009579901,0.000010995263,0.00001597065],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000118830576,0.00027063987,0.00028451686,0.00025954944,0.00017532863,0.0002882869,0.00011171326,0.00025633493,0.001859132],"category_scores_gemma":[0.000091043345,0.00019579395,0.00039072675,0.00023135508,0.00016879046,0.00015481605,0.0001410421,0.00048171444,0.00043981295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011118969,0.00003516528,0.0004150323,0.000029530354,0.000007964687,0.00004752779,0.000014315849,0.000040738596,0.9985563,0.000044659555,0.00007162731,0.0006258654],"study_design_scores_gemma":[0.000044403554,0.00076835987,0.016003959,0.0000072183348,0.000042701016,0.00045096787,0.00007078777,0.0014994943,0.9774278,0.000042708143,0.0036343697,0.000007317938],"about_ca_topic_score_codex":0.0009826827,"about_ca_topic_score_gemma":0.0012000089,"teacher_disagreement_score":0.001859132,"about_ca_system_score_codex":0.00028965727,"about_ca_system_score_gemma":0.00019004276,"threshold_uncertainty_score":0.006219387},"labels":[],"label_agreement":null},{"id":"W2049219670","doi":"10.3899/jrheum.081115","title":"Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Takeda Science Foundation","keywords":"Gene knockdown; Histone deacetylase 2; Cell growth; HDAC1; Apoptosis; Molecular biology; Cancer research; Medicine; Synovial membrane; Small interfering RNA; Downregulation and upregulation; Biology; Arthritis; Immunology; Histone; Histone deacetylase; Transfection; Cell culture; Biochemistry","score_opus":0.007207672139088317,"score_gpt":0.2687975871085464,"score_spread":0.2615899149694581,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049219670","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9543662,0.037345465,0.005090064,0.00020076739,0.00008185796,0.000050559942,0.0007677101,0.00006960497,0.0020276613],"genre_scores_gemma":[0.9860989,0.008224502,0.003161011,0.000075592245,0.000036200236,0.00004928413,0.0005881847,0.000009586931,0.0017567386],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977535,0.000022862208,0.000028955383,0.000055731904,0.000076960576,0.000040119183],"domain_scores_gemma":[0.9998969,0.000018033474,0.000031964926,0.00001026157,0.000027115038,0.000015785668],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028408697,0.0003679833,0.00028552473,0.00024304484,0.0001822053,0.00032169744,0.00016125047,0.00025654936,0.00075338903],"category_scores_gemma":[0.00014964322,0.00012226817,0.00031085193,0.00021658101,0.0001945835,0.00019166454,0.00010560283,0.00024975918,0.00029256032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012295385,0.000017745811,0.0009877485,0.00013268019,0.000014167718,0.00008459694,0.000023013854,0.00003794216,0.99552083,0.00003508571,0.000032969376,0.0029903224],"study_design_scores_gemma":[0.00005957782,0.00076663645,0.026105467,0.000027220867,0.00010249131,0.00099616,0.00012917671,0.0007881473,0.9653804,0.00005712776,0.005571089,0.000016470613],"about_ca_topic_score_codex":0.0009491439,"about_ca_topic_score_gemma":0.0014063537,"teacher_disagreement_score":0.0009491439,"about_ca_system_score_codex":0.00035129592,"about_ca_system_score_gemma":0.00021924902,"threshold_uncertainty_score":0.0025488138},"labels":[],"label_agreement":null},{"id":"W2051806959","doi":"10.1056/nejmoa041892","title":"Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease","year":2005,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":962,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Histone deacetylase 2; Medicine; COPD; Histone deacetylase 5; Histone deacetylase; Proinflammatory cytokine; Acetylation; HDAC8; Immunology; Histone; Histone acetyltransferase; Cancer research; Inflammation; Internal medicine; Pathology; Biology; Biochemistry","score_opus":0.011810924575414548,"score_gpt":0.30053154574196667,"score_spread":0.2887206211665521,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2051806959","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94265205,0.052861754,0.000913643,0.00044456523,0.000092001304,0.000032480297,0.0009289024,0.00003345701,0.0020410486],"genre_scores_gemma":[0.9936226,0.0047080223,0.00041554729,0.00010048422,0.00006416079,0.000013521365,0.0006165222,0.0000026377113,0.00045645994],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9998629,0.000019804012,0.000014579381,0.000040263487,0.00004029007,0.00002219328],"domain_scores_gemma":[0.9997774,0.000025936142,0.0000948938,0.00000989466,0.000049020935,0.000042897234],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022492792,0.00025814865,0.00025851588,0.00047881686,0.0001893845,0.00024316006,0.00017447562,0.0002978156,0.0010801315],"category_scores_gemma":[0.00031794223,0.000080057616,0.00019828553,0.00040986095,0.00022830829,0.000106627056,0.00017493038,0.0003307286,0.00019748737],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019265683,0.000172359,0.58917505,0.0011121846,0.00040408742,0.00078656024,0.00018852105,0.00038106492,0.348082,0.00024593243,0.0012359227,0.056289855],"study_design_scores_gemma":[0.00002523094,0.0003166382,0.9848712,0.000041244883,0.000070275826,0.0010787698,0.000052926003,0.00020885102,0.010361381,0.0001309735,0.0028361634,0.0000063348693],"about_ca_topic_score_codex":0.0012189129,"about_ca_topic_score_gemma":0.0017105622,"teacher_disagreement_score":0.0012189129,"about_ca_system_score_codex":0.00032634306,"about_ca_system_score_gemma":0.00017015009,"threshold_uncertainty_score":0.0036133528},"labels":[],"label_agreement":null},{"id":"W2052064733","doi":"10.1089/scd.2008.0235","title":"Valproic Acid Increases CXCR4 Expression in Hematopoietic Stem/Progenitor Cells by Chromatin Remodeling","year":2008,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Blood Services; Alberta Cancer Foundation; University of Alberta","funders":"","keywords":"Biology; Chromatin remodeling; Progenitor cell; Haematopoiesis; CXCR4; Cell biology; Chromatin; Stem cell; Valproic Acid; Cancer research; Genetics; Neuroscience; Gene; Receptor","score_opus":0.01564472870256341,"score_gpt":0.23303424889169405,"score_spread":0.21738952018913063,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052064733","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9969047,0.0015477733,0.0006414087,0.000051596253,0.000012570358,0.000008735619,0.00013916647,0.000049591054,0.0006445209],"genre_scores_gemma":[0.9971872,0.0008630374,0.0007929827,0.000029382909,0.000007676819,0.000010891311,0.00023797262,0.000009828263,0.0008609301],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994063,0.000018364475,0.0000061302453,0.000011323285,0.000009744773,0.000013821758],"domain_scores_gemma":[0.99995375,0.000008863487,0.00001785222,0.000004747922,0.0000040623677,0.0000107445785],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008045911,0.00016528784,0.00013978209,0.00012073918,0.00006553466,0.00021838526,0.000079507474,0.00008617633,0.0011505351],"category_scores_gemma":[0.00009035016,0.00008631302,0.00011710903,0.00007851625,0.0001428174,0.00008710705,0.00008377677,0.00017088972,0.00015390101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002575109,0.00001892086,0.00040674163,0.00002832332,0.000005511297,0.000019875162,0.000007400258,0.00005866345,0.9960859,0.000059649636,0.00004003839,0.0030115147],"study_design_scores_gemma":[0.000041844458,0.0006223478,0.007222773,0.00000390132,0.00001695482,0.00016267684,0.000018898027,0.00035519386,0.9897395,0.000051477124,0.0017622486,0.0000021434569],"about_ca_topic_score_codex":0.0003629399,"about_ca_topic_score_gemma":0.0006447496,"teacher_disagreement_score":0.0011505351,"about_ca_system_score_codex":0.00019344322,"about_ca_system_score_gemma":0.00011612823,"threshold_uncertainty_score":0.00384897},"labels":[],"label_agreement":null},{"id":"W2052373759","doi":"10.1016/s1097-2765(01)00429-4","title":"Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR","year":2002,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":750,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Biology; Multiprotein complex; Enzyme; Cell biology; Genetics; Biochemistry; Gene","score_opus":0.021450738444154835,"score_gpt":0.24287576300409372,"score_spread":0.2214250245599389,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052373759","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96552247,0.006362334,0.017701125,0.00029474706,0.00021663343,0.00007130621,0.001206648,0.0005954026,0.008029297],"genre_scores_gemma":[0.98433775,0.00089055253,0.005351983,0.00009060371,0.00003567024,0.000031924657,0.002516206,0.0001015702,0.0066438355],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99974424,0.00002061232,0.000018289564,0.00007065927,0.00006428748,0.00008205957],"domain_scores_gemma":[0.99977034,0.000020539232,0.00005189975,0.00004761181,0.000038922455,0.000070724214],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026668783,0.0005606167,0.00036930875,0.0003134446,0.0005618765,0.00073201035,0.00032399478,0.00023562327,0.002105059],"category_scores_gemma":[0.00021141174,0.00025893844,0.0007387094,0.00027806542,0.0002998421,0.00032238488,0.00038218405,0.00063202484,0.0015807714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012703739,0.000019352432,0.000623879,0.00002247089,0.000014991784,0.00004013831,0.0000074915292,0.000016403143,0.9974619,0.0001617466,0.000106877495,0.001397642],"study_design_scores_gemma":[0.000016560993,0.000054543,0.021584792,0.000004649021,0.000019345574,0.00047333515,0.000024930345,0.0006270038,0.9731433,0.00014177349,0.0039016313,0.000008090487],"about_ca_topic_score_codex":0.0025464732,"about_ca_topic_score_gemma":0.005130138,"teacher_disagreement_score":0.0025464732,"about_ca_system_score_codex":0.0013604305,"about_ca_system_score_gemma":0.0006246399,"threshold_uncertainty_score":0.009870648},"labels":[],"label_agreement":null},{"id":"W2052966638","doi":"10.1074/jbc.m113.456996","title":"The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Histone H3; Histone; Histone deacetylase 5; Cell biology; Kinase; Mef2; Nuclear export signal; HDAC4; Transcription factor; Acetylation; Phosphorylation; Biology; Chemistry; Histone deacetylase; Biochemistry; Gene; Enhancer; Cell nucleus","score_opus":0.013703824451180506,"score_gpt":0.2725446681324206,"score_spread":0.2588408436812401,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052966638","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9804577,0.005911154,0.0060710087,0.00032405974,0.00011931421,0.000032137832,0.00063341955,0.00024114228,0.0062100734],"genre_scores_gemma":[0.9914915,0.001593888,0.0017787898,0.00006781389,0.000022370241,0.000025826168,0.0008221535,0.000024268707,0.0041733687],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995005,0.0000069818498,0.000002981176,0.00001085559,0.000013206308,0.000015923695],"domain_scores_gemma":[0.99996793,0.000004230729,0.000010044881,0.0000030411713,0.000004358251,0.000010415153],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006234082,0.00042781187,0.00016716015,0.00016345877,0.00017681037,0.00020699523,0.0000953327,0.00012914275,0.0022741498],"category_scores_gemma":[0.00006713993,0.00015253441,0.0002544129,0.00011783692,0.00014277997,0.00015086058,0.0002762967,0.00033137592,0.00086814846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012405845,0.000011628384,0.0006130628,0.00004931355,0.000008810357,0.000069217174,0.000010732776,0.000110623616,0.996971,0.00016076158,0.00013566006,0.0017350881],"study_design_scores_gemma":[0.00005263975,0.0002575425,0.014701912,0.000009857851,0.000017423663,0.0005798748,0.000041191044,0.0018194987,0.9734875,0.0002477811,0.008775815,0.000008929802],"about_ca_topic_score_codex":0.00039510897,"about_ca_topic_score_gemma":0.0011997957,"teacher_disagreement_score":0.0022741498,"about_ca_system_score_codex":0.00036360396,"about_ca_system_score_gemma":0.00022519701,"threshold_uncertainty_score":0.0076078176},"labels":[],"label_agreement":null},{"id":"W2053391602","doi":"10.1371/journal.pone.0084046","title":"Nuclear Localization of the Transcriptional Regulator MIER1α Requires Interaction with HDAC1/2 in Breast Cancer Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Nuclear localization sequence; Gene knockdown; Nuclear transport; Cell nucleus; Small hairpin RNA; Chromatin; Nuclear protein; Cell biology; Biology; Transcription factor; Molecular biology; Regulator; Estrogen receptor alpha; Nucleus; Estrogen receptor; Gene; Genetics; Breast cancer; Cancer","score_opus":0.014972994941960976,"score_gpt":0.22348360173595888,"score_spread":0.2085106067939979,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2053391602","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98464185,0.0049269,0.00553504,0.00030193457,0.000059550915,0.000038236507,0.0013065367,0.00015939251,0.0030306822],"genre_scores_gemma":[0.9840911,0.0017455127,0.0031459497,0.00013668326,0.000016131318,0.000057868714,0.0035959526,0.000049464845,0.0071614147],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976116,0.00002683281,0.000019614481,0.000060024366,0.000077273515,0.000055075627],"domain_scores_gemma":[0.9999236,0.000009695504,0.000021613994,0.000016035754,0.000009402691,0.000019676856],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018515,0.0002870144,0.00033178623,0.00016589698,0.00023991162,0.00037587443,0.00030662815,0.00024650182,0.0014771193],"category_scores_gemma":[0.000118829885,0.00021146637,0.00035146892,0.00020092675,0.00019283826,0.00016716636,0.00020966168,0.00052771776,0.0011109838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000064288244,0.000014674921,0.00016116595,0.000026402895,0.000005073055,0.000030277537,0.0000112526395,0.000028902712,0.9989755,0.000057455898,0.000045357177,0.00057961285],"study_design_scores_gemma":[0.000021153213,0.000109814035,0.012193563,0.000006908973,0.0000136590525,0.00037564227,0.00003538492,0.0009041792,0.98097163,0.000026277541,0.0053379275,0.000003831329],"about_ca_topic_score_codex":0.0012517107,"about_ca_topic_score_gemma":0.0018686604,"teacher_disagreement_score":0.0014771193,"about_ca_system_score_codex":0.0005523821,"about_ca_system_score_gemma":0.00019706643,"threshold_uncertainty_score":0.0049414635},"labels":[],"label_agreement":null},{"id":"W2054233677","doi":"10.1007/s13311-013-0228-z","title":"Epigenetics of Neural Repair Following Spinal Cord Injury","year":2013,"lang":"en","type":"review","venue":"Neurotherapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"","keywords":"Neuroscience; Spinal cord injury; Spinal cord; Central nervous system; Medicine; Biology","score_opus":0.07782792623367334,"score_gpt":0.4078148844610375,"score_spread":0.3299869582273641,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054233677","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00014996828,0.998309,0.00022653583,0.00029094657,0.0002053441,0.0000028724967,0.000013754258,0.0000071259515,0.0007943747],"genre_scores_gemma":[0.0013421089,0.9971288,0.00018722854,0.00022203957,0.00024029045,0.000005538454,0.000024224242,0.0000015709685,0.00084823766],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999074,0.000015144762,0.00001159275,0.000018181203,0.000034838155,0.000012948394],"domain_scores_gemma":[0.99988186,0.00005272203,0.000020738084,0.0000048111083,0.000028604174,0.000011274045],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004086543,0.0006560045,0.0010256843,0.0008895573,0.00020042792,0.00060670334,0.00075635215,0.0008516057,0.0019290872],"category_scores_gemma":[0.0004175776,0.00021524722,0.00028064917,0.0010540913,0.0004987757,0.00066412,0.00051109784,0.0012963272,0.0009274433],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010351631,0.000047282527,0.00017563032,0.0065288637,0.00008364926,0.00021722102,0.00003068967,0.00043529514,0.0046655415,0.0039436356,0.027700296,0.9560685],"study_design_scores_gemma":[0.000033701897,0.00009639374,0.0012869622,0.0017753525,0.00015282856,0.0011576206,0.000059974172,0.00019919472,0.0022121458,0.0037189906,0.9892825,0.000024157182],"about_ca_topic_score_codex":0.00103268,"about_ca_topic_score_gemma":0.0031282385,"teacher_disagreement_score":0.0019290872,"about_ca_system_score_codex":0.00063439505,"about_ca_system_score_gemma":0.00070788315,"threshold_uncertainty_score":0.006453395},"labels":[],"label_agreement":null},{"id":"W2054550062","doi":"10.1016/j.bmc.2011.01.063","title":"Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Wilhelm Sander-Stiftung","keywords":"PCAF; Histone acetyltransferase; Acetylation; Chemistry; Virtual screening; Histone; Acetyltransferase; Biochemistry; In vitro; Computational biology; Cancer research; Drug discovery; Biology; Gene","score_opus":0.04746943749567505,"score_gpt":0.27995242689668287,"score_spread":0.2324829894010078,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054550062","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9649366,0.011771459,0.01020908,0.0003937128,0.00015067213,0.0005405455,0.0014363636,0.00023344171,0.010328068],"genre_scores_gemma":[0.9825339,0.006441528,0.005338752,0.00008600481,0.00002433236,0.00013350279,0.0010911223,0.000017966435,0.0043327217],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998723,0.000023325305,0.000015840866,0.000016735454,0.000033725817,0.000038006063],"domain_scores_gemma":[0.9999106,0.000015249684,0.000015586522,0.000010329047,0.000022929236,0.000025294235],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036274287,0.00040875477,0.00035592046,0.00032039572,0.0002773455,0.0003172295,0.00054812647,0.0003198351,0.0017746085],"category_scores_gemma":[0.00025866381,0.00019608931,0.00028407152,0.00034287907,0.00020818936,0.00026605822,0.00022540816,0.00045074892,0.0003791651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00079050596,0.00038995306,0.00044420065,0.00035862508,0.000040948402,0.0005112606,0.00013779354,0.0025056144,0.97542316,0.00088829536,0.0005136357,0.017996076],"study_design_scores_gemma":[0.00041264543,0.004503272,0.0012948179,0.0000268847,0.00008881462,0.0004236151,0.000045640958,0.0014432145,0.9816382,0.00014625178,0.009952336,0.000024270565],"about_ca_topic_score_codex":0.001594744,"about_ca_topic_score_gemma":0.0032128384,"teacher_disagreement_score":0.0017746085,"about_ca_system_score_codex":0.0005166218,"about_ca_system_score_gemma":0.0004971561,"threshold_uncertainty_score":0.005936682},"labels":[],"label_agreement":null},{"id":"W2054688665","doi":"10.1038/srep00220","title":"Histone Deacetylase Inhibitors Globally Enhance H3/H4 Tail Acetylation Without Affecting H3 Lysine 56 Acetylation","year":2012,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Acetylation; Histone H3; Histone deacetylase; Histone; Lysine; Histone H4; SAP30; Histone deacetylase 2; HDAC11; Chemistry; Histone Acetyltransferases; Histone H2A; Biology; Cancer research; Biochemistry; Molecular biology; Amino acid; Gene","score_opus":0.010867887083458894,"score_gpt":0.30870820030271845,"score_spread":0.2978403132192596,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054688665","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98692244,0.00513045,0.0032195726,0.00016351929,0.00009999452,0.000049016646,0.00073553197,0.00019181405,0.0034877094],"genre_scores_gemma":[0.9923849,0.002282163,0.001991167,0.0000885777,0.000023306744,0.000020271065,0.00062542054,0.000029662911,0.0025545217],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998785,0.0000131540555,0.000010281817,0.000029169134,0.00003481174,0.000034094366],"domain_scores_gemma":[0.9999318,0.000015960351,0.000016255826,0.0000082963315,0.000007852247,0.000019906041],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015823783,0.00039222176,0.00038624875,0.00019889846,0.00013735425,0.00032009376,0.00018659476,0.00018792585,0.0022484665],"category_scores_gemma":[0.00010105002,0.00015066564,0.0003198125,0.00018191767,0.0002280307,0.00018268668,0.00015859811,0.0005297849,0.0004560652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014298348,0.000021821816,0.00016519568,0.000022577127,0.000012532972,0.000008812188,0.0000029776766,0.000030291132,0.9982344,0.00002331941,0.000031837215,0.0013031645],"study_design_scores_gemma":[0.000015720923,0.00032654894,0.002123923,0.0000012774736,0.000017404263,0.000049836923,0.000006876993,0.00014063915,0.9963277,0.000013175972,0.00097534753,0.0000015871587],"about_ca_topic_score_codex":0.0010113848,"about_ca_topic_score_gemma":0.002508689,"teacher_disagreement_score":0.0022484665,"about_ca_system_score_codex":0.0003009352,"about_ca_system_score_gemma":0.0002476802,"threshold_uncertainty_score":0.0075218678},"labels":[],"label_agreement":null},{"id":"W2055237164","doi":"10.1021/jm101092u","title":"Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Pharmacophore; Tetrapeptide; Vorinostat; Histone deacetylase; Stereochemistry; Histone; Depsipeptide; HDAC6; Isozyme; Structure–activity relationship; Combinatorial chemistry; Biochemistry; Enzyme; Peptide; DNA; In vitro","score_opus":0.007811608708286867,"score_gpt":0.30083956110120713,"score_spread":0.2930279523929203,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2055237164","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9345315,0.01653801,0.036822207,0.00022339744,0.00012677471,0.00079830445,0.0010221986,0.0002967041,0.009640831],"genre_scores_gemma":[0.96543115,0.0066703265,0.023563059,0.00011459048,0.000036949168,0.00030387891,0.00078296475,0.000036107187,0.003060992],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999242,0.000014901061,0.000007848153,0.00001731609,0.000021989705,0.000013835682],"domain_scores_gemma":[0.9999254,0.000008833229,0.000022383872,0.0000064006285,0.000012337276,0.00002456243],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003534,0.00038879077,0.00035623735,0.00017544186,0.000091212016,0.00022541375,0.00037423187,0.00016913604,0.001183981],"category_scores_gemma":[0.00020631247,0.000114683666,0.00014690371,0.00014239547,0.00017075388,0.00016925785,0.00016378173,0.00029223974,0.00032310424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00064106396,0.00013651297,0.00037518074,0.0002945417,0.000028654435,0.00021701581,0.000031507618,0.003704731,0.9580317,0.0015490981,0.00025618996,0.034733802],"study_design_scores_gemma":[0.0003559213,0.0039181225,0.0015179481,0.000020252059,0.00005029906,0.00051810796,0.00002062935,0.0039257784,0.9746295,0.0002655945,0.014753661,0.000024208164],"about_ca_topic_score_codex":0.00025466576,"about_ca_topic_score_gemma":0.0008287225,"teacher_disagreement_score":0.001183981,"about_ca_system_score_codex":0.0003162095,"about_ca_system_score_gemma":0.00022634178,"threshold_uncertainty_score":0.003960848},"labels":[],"label_agreement":null},{"id":"W2057938810","doi":"10.1186/1479-5876-8-s1-p60","title":"Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes","year":2010,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Valproic Acid; Prostaglandin E2; Histone deacetylase; Chemistry; Interleukin; Prostaglandin; Histone deacetylase inhibitor; Microsome; Retinoic acid; Pharmacology; Histone; Biochemistry; Cytokine; Enzyme; Endocrinology; Internal medicine; Medicine; Biology; Epilepsy; Gene; Neuroscience","score_opus":0.013558072641327756,"score_gpt":0.30094135114983933,"score_spread":0.2873832785085116,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2057938810","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99540895,0.0036769556,0.000281932,0.000061710096,0.00003177109,0.00001064519,0.00011865882,0.000027855855,0.00038151315],"genre_scores_gemma":[0.9967359,0.0016198138,0.00034034954,0.0000444262,0.000015444539,0.00001463585,0.00019141185,0.000008017031,0.0010300485],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988306,0.000025514364,0.000022249611,0.000016570137,0.000024325624,0.000028205437],"domain_scores_gemma":[0.99989736,0.000014659034,0.000028391707,0.0000123543905,0.000014506349,0.00003264825],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012528578,0.0003288908,0.00036971137,0.00017090293,0.00012516398,0.00023968893,0.00012628803,0.00016373536,0.0007114212],"category_scores_gemma":[0.00013245901,0.00012550279,0.00023171956,0.00011783108,0.00025345053,0.00013206288,0.00013812548,0.00047010797,0.00019616338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016993626,0.000101235164,0.0003670457,0.000091309055,0.000017438559,0.000061838386,0.000034690143,0.00007523022,0.9942199,0.000022262031,0.0000477804,0.0032619003],"study_design_scores_gemma":[0.00030020194,0.0055076405,0.012384701,0.000016215936,0.00006739439,0.00034169696,0.00015106304,0.0005989761,0.9778456,0.000053605938,0.0027243055,0.000008679756],"about_ca_topic_score_codex":0.0010939117,"about_ca_topic_score_gemma":0.001835991,"teacher_disagreement_score":0.0010939117,"about_ca_system_score_codex":0.00016936731,"about_ca_system_score_gemma":0.00033233644,"threshold_uncertainty_score":0.0023798943},"labels":[],"label_agreement":null},{"id":"W2057946453","doi":"10.1053/j.gastro.2009.04.004","title":"E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex","year":2009,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":352,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Medical Research Council; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Centre in Green Chemistry and Catalysis","keywords":"Pancreatic cancer; Cancer research; Metastasis; Gene silencing; Biology; KRAS; Epithelial–mesenchymal transition; Epigenetics; Cancer; Genetics; Colorectal cancer; Gene","score_opus":0.012190201670588884,"score_gpt":0.28320683945387515,"score_spread":0.2710166377832863,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2057946453","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9911177,0.0022445691,0.0034134225,0.00019734801,0.00004111295,0.000015686512,0.0004159056,0.0001978719,0.0023564477],"genre_scores_gemma":[0.99416816,0.00054633163,0.0008994991,0.000038699596,0.000010105419,0.000017077187,0.0005916539,0.000043782475,0.003684696],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997249,0.000033018838,0.000022321005,0.000043727337,0.000090349124,0.000085733],"domain_scores_gemma":[0.999835,0.000017675184,0.00004054693,0.000023350587,0.000014588641,0.00006886131],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021715854,0.00038894924,0.00031891704,0.00044738664,0.0003430481,0.0006094458,0.0003329174,0.00017101948,0.0019059787],"category_scores_gemma":[0.00014058946,0.0004491163,0.00029768105,0.00026885787,0.00038292987,0.00030105058,0.00038824687,0.00073682825,0.0006293836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011572998,0.000014661407,0.00020501316,0.000012483268,0.0000047902954,0.00002724052,0.000006070894,0.00003367652,0.99897647,0.00013892235,0.000052245887,0.00041270562],"study_design_scores_gemma":[0.00003440051,0.000058942678,0.010747043,0.0000028694565,0.0000147281535,0.0002141764,0.00002855658,0.0019237284,0.98502326,0.00006698242,0.0018804381,0.000004884043],"about_ca_topic_score_codex":0.0014673915,"about_ca_topic_score_gemma":0.0033887154,"teacher_disagreement_score":0.0019059787,"about_ca_system_score_codex":0.0007239235,"about_ca_system_score_gemma":0.00033809367,"threshold_uncertainty_score":0.0063761473},"labels":[],"label_agreement":null},{"id":"W2058765546","doi":"10.1038/cddis.2012.210","title":"Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance","year":2013,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Vorinostat; Autophagy; Biology; Cell biology; Programmed cell death; Histone deacetylase; Cancer research; Gene knockdown; Cell culture; Apoptosis; Histone; Biochemistry; Genetics","score_opus":0.011827109881281031,"score_gpt":0.24806124261507756,"score_spread":0.23623413273379654,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2058765546","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98620504,0.004163247,0.003987479,0.00032044982,0.00007981254,0.00008232211,0.0007821577,0.00029519672,0.0040842863],"genre_scores_gemma":[0.9946808,0.001350643,0.0018111198,0.00007240508,0.0000149930465,0.000047508962,0.00067846855,0.000021395264,0.0013227263],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982846,0.000029874574,0.000024127454,0.00003377139,0.000049664784,0.000034105542],"domain_scores_gemma":[0.99993026,0.00001231533,0.000021716578,0.000015531437,0.000008346052,0.00001182717],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014372315,0.00035971505,0.00035928353,0.00027431734,0.00014168724,0.00048110416,0.00020605259,0.00026063184,0.00084318046],"category_scores_gemma":[0.00011166491,0.0001502814,0.00028460936,0.00021956867,0.00018495043,0.000214797,0.00016275038,0.00060531974,0.00041786535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007921612,0.000032705117,0.00021904983,0.000036922556,0.000009012952,0.00007800711,0.000010508496,0.0002119141,0.9961139,0.00022045312,0.00014139009,0.0028469274],"study_design_scores_gemma":[0.000028085176,0.00031069448,0.0021930847,0.000005488277,0.000020094054,0.0003353311,0.000016848493,0.0011736025,0.99148,0.000099353274,0.004331157,0.00000624846],"about_ca_topic_score_codex":0.00016568042,"about_ca_topic_score_gemma":0.0005154413,"teacher_disagreement_score":0.00084318046,"about_ca_system_score_codex":0.0004662599,"about_ca_system_score_gemma":0.0001547188,"threshold_uncertainty_score":0.0033829212},"labels":[],"label_agreement":null},{"id":"W2059613997","doi":"10.1016/j.ccr.2011.10.015","title":"Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia","year":2011,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":694,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Myeloid leukemia; Tigecycline; Leukemia; Biology; Mitochondrion; Haematopoiesis; Myeloid; Cancer research; Translation (biology); Gene knockdown; HL60; Progenitor cell; Mitochondrial biogenesis; Stem cell; Apoptosis; Cell biology; Molecular biology; Biochemistry; Immunology; Gene; Messenger RNA; Antibiotics","score_opus":0.04847561866900412,"score_gpt":0.32304638219247445,"score_spread":0.2745707635234703,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2059613997","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9561843,0.02453114,0.008215927,0.0021302355,0.00058315485,0.00026878988,0.00072532514,0.00030846137,0.007052491],"genre_scores_gemma":[0.98379415,0.010216921,0.0023750782,0.00018134664,0.00006131266,0.000084817395,0.00040312533,0.000022469785,0.002860733],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993646,0.0000113659735,0.0000056240006,0.000011542749,0.000014637269,0.00002035209],"domain_scores_gemma":[0.9999653,0.000007491967,0.000009226269,0.00000522707,0.0000048388615,0.0000079300025],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022302498,0.00037659946,0.0003402918,0.00025777923,0.00027060762,0.00035022717,0.00023370847,0.00023896535,0.0014396523],"category_scores_gemma":[0.000093781484,0.00010761092,0.00025957715,0.00030889534,0.0002474213,0.00016370804,0.00019506928,0.00095909333,0.00030390726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017873386,0.0004921575,0.00046862764,0.00036800196,0.00006220993,0.00021911683,0.000071601215,0.0009113897,0.9390287,0.003415986,0.0016649672,0.051509887],"study_design_scores_gemma":[0.0006966092,0.0042180084,0.0022507545,0.00003168991,0.00014145524,0.0005102583,0.000076708275,0.0017017267,0.9572666,0.00062385906,0.0324674,0.000014929406],"about_ca_topic_score_codex":0.00062813354,"about_ca_topic_score_gemma":0.0016853084,"teacher_disagreement_score":0.0014396523,"about_ca_system_score_codex":0.00046514857,"about_ca_system_score_gemma":0.0003149678,"threshold_uncertainty_score":0.0048161745},"labels":[],"label_agreement":null},{"id":"W2061563398","doi":"10.1158/0008-5472.can-08-2893","title":"Repression of 15-Hydroxyprostaglandin Dehydrogenase Involves Histone Deacetylase 2 and Snail in Colorectal Cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; U.S. Public Health Service; Universität Hamburg; Universitat Pompeu Fabra","keywords":"Histone deacetylase; Histone deacetylase 2; HDAC1; Cancer research; Azoxymethane; Snail; Colorectal cancer; Biology; Histone; Chemistry; Cancer; Biochemistry; Genetics","score_opus":0.045492192536351804,"score_gpt":0.38897439182148624,"score_spread":0.34348219928513446,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061563398","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98325205,0.010210764,0.0028687709,0.00027899334,0.000046901678,0.000039072955,0.00032591505,0.0001216175,0.0028559736],"genre_scores_gemma":[0.9943017,0.0022285979,0.00093093084,0.000046003726,0.0000067109104,0.000015587868,0.00023050747,0.000006006535,0.002233892],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992955,0.000013005711,0.000006393078,0.000015734811,0.000018288365,0.000017003846],"domain_scores_gemma":[0.9999509,0.000004437946,0.00001674346,0.000004938127,0.0000057404454,0.000017336215],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009737626,0.00019416575,0.00015756031,0.00015299137,0.00009811933,0.00020722015,0.00010170352,0.00012983606,0.0008021665],"category_scores_gemma":[0.00007492699,0.00013490308,0.00016323217,0.00012751065,0.00022673703,0.000102838785,0.00014229964,0.00025808613,0.00021909857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019869514,0.000012214634,0.00089284615,0.00005543171,0.0000057548755,0.00007531145,0.000009859362,0.000064440705,0.9967096,0.00014854665,0.000052132153,0.0017753327],"study_design_scores_gemma":[0.000060559396,0.0005749701,0.039229173,0.000010879054,0.000026650114,0.0010098321,0.00005833891,0.0013153041,0.94857013,0.00013624111,0.008999751,0.000008043835],"about_ca_topic_score_codex":0.0006745932,"about_ca_topic_score_gemma":0.0017570859,"teacher_disagreement_score":0.0008021665,"about_ca_system_score_codex":0.00031524478,"about_ca_system_score_gemma":0.00020452426,"threshold_uncertainty_score":0.0026834607},"labels":[],"label_agreement":null},{"id":"W2063284451","doi":"10.1074/jbc.m500295200","title":"Identification of the Ankyrin Repeat Proteins ANKRA and RFXANK as Novel Partners of Class IIa Histone Deacetylases","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"CIITA; Ankyrin repeat; HDAC4; Biology; Genetics; Transcription factor; Coactivator; Cell biology; Protein subunit; Histone deacetylase 5; Histone deacetylase; Histone; MHC class II; Gene; Major histocompatibility complex","score_opus":0.02240359195586936,"score_gpt":0.3193488557075946,"score_spread":0.2969452637517252,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063284451","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99553764,0.0015410439,0.0015623342,0.000053464624,0.00001258323,0.000010407419,0.00017887489,0.00005559611,0.0010480747],"genre_scores_gemma":[0.9922754,0.00061556534,0.0026902359,0.000040231458,0.000014786133,0.000014132633,0.0010174774,0.00001663149,0.0033154716],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987483,0.000020963207,0.000007899569,0.000032292835,0.000032182892,0.00003179691],"domain_scores_gemma":[0.9999181,0.000012006358,0.000024020144,0.00000949522,0.00000930387,0.00002705272],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012587398,0.00031397815,0.0002371197,0.00021639379,0.00018382401,0.00036838517,0.00033378816,0.00022031712,0.0012938085],"category_scores_gemma":[0.00018669797,0.00021038418,0.00027383992,0.00013841857,0.00011567211,0.00020827037,0.00031525083,0.00022827584,0.0005758173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019996583,0.000024459318,0.0046908893,0.000042793657,0.000021684516,0.0005942339,0.000027151205,0.0001253418,0.9913067,0.00019839474,0.000105820916,0.002662674],"study_design_scores_gemma":[0.00009565364,0.0005065089,0.16125949,0.000026078378,0.00013881971,0.011160063,0.00025045447,0.008346936,0.7950018,0.0005544126,0.022615816,0.000043973214],"about_ca_topic_score_codex":0.0002939022,"about_ca_topic_score_gemma":0.00031013024,"teacher_disagreement_score":0.0012938085,"about_ca_system_score_codex":0.00028988824,"about_ca_system_score_gemma":0.00009791455,"threshold_uncertainty_score":0.0043281913},"labels":[],"label_agreement":null},{"id":"W2063541180","doi":"10.1016/j.bmcl.2007.07.050","title":"Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre","funders":"","keywords":"Chemistry; Thiazole; Hydroxamic acid; Histone deacetylase; HeLa; Histone deacetylase inhibitor; Sulfonamide; Stereochemistry; Piperazine; Cervical carcinoma; Ring (chemistry); Enzyme; Biochemistry; Histone; In vitro; Cancer; DNA; Cervical cancer; Organic chemistry","score_opus":0.009888275007316191,"score_gpt":0.26341793382902495,"score_spread":0.25352965882170875,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063541180","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91523474,0.020788437,0.04409779,0.0006390997,0.00038878273,0.00064631144,0.0010042553,0.0004583978,0.016742155],"genre_scores_gemma":[0.96807,0.008921692,0.01562209,0.00011950737,0.000050520634,0.00016626202,0.00059062045,0.000024805011,0.006434523],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999188,0.00001272138,0.000008280163,0.000013003661,0.000015460797,0.000031773816],"domain_scores_gemma":[0.99995184,0.0000054636257,0.000012546539,0.0000043647738,0.000009772708,0.000016070286],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024418088,0.00036713394,0.00036126634,0.0002386384,0.00022406809,0.0003119635,0.0005543499,0.00030389015,0.0016836366],"category_scores_gemma":[0.00017001062,0.00022039402,0.00022997329,0.00022337952,0.00017945883,0.00020621257,0.00018982707,0.00043378613,0.00047769104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006300493,0.00017240581,0.0002984675,0.0005081492,0.00004381683,0.0005485822,0.00016685667,0.0037420362,0.95844984,0.0033676738,0.0008745029,0.031197699],"study_design_scores_gemma":[0.00044843345,0.0022077626,0.0012516973,0.000039106664,0.00009813298,0.00054819905,0.00005231952,0.00452824,0.9492175,0.00035010936,0.04121786,0.000040652358],"about_ca_topic_score_codex":0.00096040184,"about_ca_topic_score_gemma":0.002335517,"teacher_disagreement_score":0.0016836366,"about_ca_system_score_codex":0.00049879495,"about_ca_system_score_gemma":0.00034379782,"threshold_uncertainty_score":0.0056322813},"labels":[],"label_agreement":null},{"id":"W2063961339","doi":"10.1073/pnas.1113554108","title":"Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; Vetenskapsrådet; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Canadian Institutes of Health Research; Commonwealth Foundation","keywords":"SOD1; Superoxide dismutase; Cell culture; Cell growth; KRAS; Epidermal growth factor receptor; Biology; Molecular biology; Growth inhibition; Cell biology; Cancer research; Chemistry; Biochemistry; Gene; Receptor; Mutation; Enzyme; Genetics","score_opus":0.043765791031944605,"score_gpt":0.29478758579151293,"score_spread":0.2510217947595683,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063961339","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97651666,0.005310272,0.013031972,0.0006066704,0.00009376677,0.00015698097,0.001020962,0.00046757603,0.0027952332],"genre_scores_gemma":[0.97919375,0.0026274233,0.010478728,0.00014085938,0.000016613167,0.00008421894,0.0017443075,0.000028962742,0.005685153],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989045,0.000011923051,0.00000855987,0.000027496695,0.00004621389,0.000015328067],"domain_scores_gemma":[0.9999093,0.000017943734,0.000027571867,0.000009022813,0.000014790437,0.00002142919],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015984058,0.00054514414,0.00044637453,0.00040598554,0.00029202193,0.00028388065,0.00023748873,0.00037895946,0.0013006867],"category_scores_gemma":[0.0001254016,0.00024484532,0.00033320062,0.00024685907,0.00023223532,0.00012990256,0.00017588891,0.00056065357,0.00037477972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000051905758,0.000025047138,0.0003516575,0.000030637166,0.000007564226,0.000037246453,0.00000521069,0.00005624079,0.9969267,0.00005309766,0.0000826675,0.0023719552],"study_design_scores_gemma":[0.000019444613,0.00030145646,0.0021570148,0.0000029201972,0.000024322531,0.0002311609,0.0000061340365,0.00038355633,0.9941597,0.000024077803,0.0026867443,0.0000035296098],"about_ca_topic_score_codex":0.00057414116,"about_ca_topic_score_gemma":0.0015690738,"teacher_disagreement_score":0.0013006867,"about_ca_system_score_codex":0.00043259622,"about_ca_system_score_gemma":0.0002897012,"threshold_uncertainty_score":0.0043512583},"labels":[],"label_agreement":null},{"id":"W2064712921","doi":"10.1093/nar/gkq939","title":"CPLA 1.0: an integrated database of protein lysine acetylation","year":2010,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Key Research and Development Program of China; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Acetylation; Lysine; Histone; Biology; Histone Acetyltransferases; Biochemistry; Bromodomain; P300-CBP Transcription Factors; Database; Computational biology; Amino acid; Gene; Computer science","score_opus":0.03221501557103177,"score_gpt":0.3580756470991908,"score_spread":0.32586063152815903,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2064712921","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.016088674,0.0037907185,0.06428535,0.00022667005,0.00012102865,0.00044051782,0.8370151,0.07083025,0.00720164],"genre_scores_gemma":[0.016750287,0.0014901994,0.056975573,0.0001513901,0.000043686254,0.0007585042,0.9205406,0.0020680216,0.0012217669],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9985322,0.0001926853,0.00033743033,0.00047178176,0.00033586184,0.00013001211],"domain_scores_gemma":[0.9966491,0.0007937949,0.0007350103,0.0008331098,0.0005600053,0.00042912475],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0020006704,0.0024227065,0.0031073564,0.009158101,0.0009092699,0.0032927431,0.004014375,0.0013111619,0.01062236],"category_scores_gemma":[0.006644624,0.0012946683,0.0013863848,0.012788563,0.00042660764,0.0032413232,0.0032106831,0.0019820689,0.016419241],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.005062302,0.00048173754,0.026085008,0.013974612,0.0014841822,0.002221006,0.00087028026,0.010818634,0.08087101,0.018054089,0.509466,0.33061126],"study_design_scores_gemma":[0.0006006338,0.000423729,0.03866991,0.0005489923,0.00074712664,0.002417804,0.0002230288,0.024224075,0.033841483,0.018730411,0.8791941,0.0003787077],"about_ca_topic_score_codex":0.0028476964,"about_ca_topic_score_gemma":0.0031135962,"teacher_disagreement_score":0.01062236,"about_ca_system_score_codex":0.0009911526,"about_ca_system_score_gemma":0.0031408018,"threshold_uncertainty_score":0.035535336},"labels":[],"label_agreement":null},{"id":"W2065795373","doi":"10.3747/co.v15i5.371","title":"Histone Deacetylase Inhibitors as Novel Anticancer Therapeutics","year":2008,"lang":"en","type":"article","venue":"Current Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Histone deacetylase; Romidepsin; Medicine; Histone deacetylase inhibitor; Clinical trial; Pharmacology; Cancer research; Vorinostat; Cancer; Histone deacetylase 5; Histone; Biology; Internal medicine; Genetics; Gene","score_opus":0.11337061262848697,"score_gpt":0.4334222229215943,"score_spread":0.32005161029310736,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2065795373","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0143751195,0.94112116,0.006415553,0.004479318,0.002260189,0.00011388237,0.00023047562,0.0002364674,0.030767802],"genre_scores_gemma":[0.08477039,0.8709357,0.0069731483,0.0040124115,0.0014546523,0.00015150063,0.00043349084,0.00003784562,0.031230863],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985826,0.000026431266,0.000010113542,0.0000288888,0.000053163774,0.000023121047],"domain_scores_gemma":[0.9999442,0.000013886177,0.000009083706,0.000004758302,0.000015397916,0.000012744544],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041120258,0.00048061207,0.0005662409,0.00048690522,0.00020795982,0.00088152726,0.00041274066,0.00063693133,0.0036482674],"category_scores_gemma":[0.00019654045,0.00018364163,0.00033329244,0.00040963714,0.00028772728,0.00078262057,0.00036951617,0.0012626606,0.0022835254],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006431948,0.00036238343,0.00057148695,0.0030938047,0.000109410124,0.0007947245,0.0001516012,0.0012505776,0.12948176,0.048362974,0.0386237,0.7765544],"study_design_scores_gemma":[0.00023954596,0.00067485543,0.0009210273,0.0002643707,0.0000981459,0.0013285518,0.000038437713,0.0006031196,0.045281313,0.006323329,0.9442004,0.00002696779],"about_ca_topic_score_codex":0.0002704714,"about_ca_topic_score_gemma":0.0010565333,"teacher_disagreement_score":0.0036482674,"about_ca_system_score_codex":0.00055526313,"about_ca_system_score_gemma":0.00028498736,"threshold_uncertainty_score":0.012204707},"labels":[],"label_agreement":null},{"id":"W2070637069","doi":"10.1038/ja.2009.22","title":"JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634","year":2009,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Nutrasource","funders":"Japan Society for the Promotion of Science","keywords":"Streptomyces; Trichostatin A; Beta-lactam; Chemistry; Microbiology; Biology; Computational biology; Bacteria; Biochemistry; Genetics; Antibiotics; Histone deacetylase; Gene","score_opus":0.011820824429337308,"score_gpt":0.28056363444388704,"score_spread":0.26874281001454975,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2070637069","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.972887,0.009776815,0.0043650456,0.00023614772,0.000249202,0.00022703024,0.0020654078,0.0002759278,0.009917395],"genre_scores_gemma":[0.97954446,0.006399223,0.0047072703,0.00013700068,0.000045249348,0.000041962143,0.0037818786,0.00003890851,0.005304042],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994946,0.000007147443,0.0000057577026,0.0000070121273,0.000014069017,0.000016548052],"domain_scores_gemma":[0.99996305,0.0000034574653,0.0000069160546,0.0000035383766,0.000004984517,0.000018089424],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007360313,0.00040205897,0.00035428518,0.00027885553,0.00012327285,0.00024556115,0.0002870092,0.00017367938,0.0015913235],"category_scores_gemma":[0.00007432141,0.00010334535,0.00023845826,0.00025360307,0.00016791448,0.00014891059,0.00016682687,0.00040457,0.0005747892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00066821853,0.000091464164,0.00035052138,0.0002296838,0.00002440032,0.00053270627,0.000019530591,0.0004158775,0.9815155,0.00017799984,0.00031346007,0.015660523],"study_design_scores_gemma":[0.00021185927,0.002823919,0.0031474023,0.000023215778,0.000081827,0.0012704321,0.000045198907,0.00059375766,0.9729848,0.00008642044,0.01871039,0.000020760814],"about_ca_topic_score_codex":0.0007843561,"about_ca_topic_score_gemma":0.0010577877,"teacher_disagreement_score":0.0015913235,"about_ca_system_score_codex":0.00020360938,"about_ca_system_score_gemma":0.00031910438,"threshold_uncertainty_score":0.0053235292},"labels":[],"label_agreement":null},{"id":"W2070897057","doi":"10.1016/s0959-437x(03)00015-7","title":"Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression","year":2003,"lang":"en","type":"review","venue":"Current Opinion in Genetics & Development","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":237,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; National Institute for Health and Care Research","keywords":"Biology; Histone-modifying enzymes; Chromatin; Histone; Acetylation; Histone methyltransferase; Chromatin remodeling; Histone H2A; Histone code; Histone deacetylase; Cell biology; HDAC4; SAP30; Genetics; Gene; Nucleosome","score_opus":0.040840132443322144,"score_gpt":0.4002130387608614,"score_spread":0.35937290631753926,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2070897057","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0005476841,0.99227285,0.0022058475,0.0012969574,0.001200302,0.000010925971,0.000020655656,0.00002710426,0.0024176503],"genre_scores_gemma":[0.0038140677,0.9918948,0.0011559201,0.00066645065,0.000760878,0.000021798925,0.000037778485,0.0000044850117,0.0016439174],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99970275,0.00004701437,0.000035854897,0.00006489468,0.00011586217,0.00003360507],"domain_scores_gemma":[0.9997389,0.000104793595,0.00003517535,0.000017195756,0.00007189621,0.000032077005],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015625963,0.0012254256,0.0020873724,0.0009654918,0.00054787187,0.0018188917,0.0017898373,0.0021847705,0.0024578902],"category_scores_gemma":[0.0005388989,0.00046596667,0.00057666615,0.0015553916,0.0012400983,0.0031951247,0.0010264296,0.0025679609,0.002215386],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044433892,0.0000855797,0.00047729196,0.011497988,0.00024280125,0.0010896053,0.00019967144,0.0009264854,0.029503798,0.031680625,0.029803952,0.89404786],"study_design_scores_gemma":[0.00008731992,0.00014499838,0.0009502083,0.0007491089,0.00017955662,0.0017041358,0.00021460274,0.00020147818,0.005723812,0.008590469,0.9814218,0.0000325005],"about_ca_topic_score_codex":0.00092431775,"about_ca_topic_score_gemma":0.0025756767,"teacher_disagreement_score":0.0024578902,"about_ca_system_score_codex":0.0011916658,"about_ca_system_score_gemma":0.0010928838,"threshold_uncertainty_score":0.008646131},"labels":[],"label_agreement":null},{"id":"W2071947905","doi":"10.2174/0929867033456585","title":"Novel Hydroxamate and Anilide Derivatives as Potent Histone Deacetylase Inhibitors: Synthesis and Antiproliferative Evaluation","year":2003,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Histone deacetylase; Trichostatin A; Hydroxamic acid; Acetylation; Cell growth; Histone; Chemistry; Cell cycle; Cancer cell; Histone deacetylase inhibitor; Histone deacetylase 5; Histone deacetylase 2; Cell cycle checkpoint; Biochemistry; Cancer research; Biology; Cancer; Cell; Gene; Genetics; Stereochemistry","score_opus":0.05243561106004767,"score_gpt":0.3938725110748181,"score_spread":0.3414369000147704,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2071947905","genre_codex":"empirical","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6539374,0.27591833,0.028597763,0.00068386743,0.00065480353,0.0009979287,0.0017734839,0.00065116584,0.036785204],"genre_scores_gemma":[0.7828754,0.18575495,0.014186305,0.0003776623,0.00033651834,0.00032423448,0.0015204719,0.000055151642,0.014569341],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995446,0.0000073174365,0.00000497371,0.00000889463,0.000011610226,0.000012790628],"domain_scores_gemma":[0.9999529,0.000006220129,0.000010067345,0.0000033486856,0.000009321797,0.000018198616],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014745144,0.00062248466,0.00036062117,0.00038234566,0.00012676991,0.00022094989,0.00043072295,0.00030710912,0.002967169],"category_scores_gemma":[0.000099337565,0.00014514514,0.00020285306,0.00028355172,0.00014535787,0.0003284634,0.00018825977,0.00047844203,0.0008029355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047137728,0.0004555512,0.00017903247,0.0008121555,0.000041718995,0.00028487906,0.000075482276,0.0018502669,0.8989426,0.001792056,0.0011218898,0.09397295],"study_design_scores_gemma":[0.0005146828,0.0101798745,0.0035976048,0.000110335124,0.00016155046,0.0012232993,0.000048532336,0.0022972098,0.8639401,0.00048456056,0.1173899,0.000052323707],"about_ca_topic_score_codex":0.00048686203,"about_ca_topic_score_gemma":0.0008849575,"teacher_disagreement_score":0.002967169,"about_ca_system_score_codex":0.0002981099,"about_ca_system_score_gemma":0.0002004759,"threshold_uncertainty_score":0.0099262},"labels":[],"label_agreement":null},{"id":"W2073206520","doi":"10.1016/s1046-2023(03)00083-5","title":"Measurement of histone acetyltransferase and histone deacetylase activities and kinetics of histone acetylation","year":2003,"lang":"en","type":"article","venue":"Methods","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"","keywords":"Histone Acetyltransferases; Acetylation; Histone H2A; Histone deacetylase 2; Histone methyltransferase; Histone deacetylase; Histone code; SAP30; HDAC4; Histone H1; Biochemistry; HDAC11; Histone acetyltransferase; Chemistry; Histone; DNA; Nucleosome; Gene","score_opus":0.03431780979323379,"score_gpt":0.39902162703954164,"score_spread":0.36470381724630785,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073206520","genre_codex":"methods","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":"methods","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.29343578,0.009992467,0.66369027,0.000871352,0.0010132269,0.00074543484,0.0064996495,0.0028245621,0.020927185],"genre_scores_gemma":[0.56758845,0.01192932,0.32719386,0.0005585311,0.0003830142,0.0026187904,0.0141303055,0.0016766939,0.07392111],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9991678,0.000103548606,0.000080727215,0.00023114636,0.0002724201,0.00014435085],"domain_scores_gemma":[0.99899286,0.0003535431,0.00011167847,0.00021935801,0.00016221407,0.00016028553],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010445028,0.0013536202,0.00059561845,0.0010107736,0.0007087164,0.0012276453,0.0010644363,0.00059641886,0.0032819754],"category_scores_gemma":[0.0008810985,0.00082666206,0.00054980326,0.001442789,0.0006346705,0.001035222,0.0005570844,0.0031566666,0.0021867903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021942043,0.00006977122,0.0002308381,0.00006651853,0.000013265723,0.000010104348,0.000023232209,0.00006196514,0.99536324,0.00057884725,0.00012319422,0.003239657],"study_design_scores_gemma":[0.000016222057,0.000060937502,0.001144806,0.000004224849,0.000015344827,0.00003835854,0.000011673462,0.0005464901,0.99519366,0.00019085158,0.002769707,0.000007736399],"about_ca_topic_score_codex":0.0016807633,"about_ca_topic_score_gemma":0.0034051877,"teacher_disagreement_score":0.0032819754,"about_ca_system_score_codex":0.00094111875,"about_ca_system_score_gemma":0.00084103964,"threshold_uncertainty_score":0.010979295},"labels":[],"label_agreement":null},{"id":"W2074077730","doi":"10.1007/s10637-008-9190-8","title":"Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest Oncology Group study (S0336)","year":2008,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Romidepsin; Medicine; Colorectal cancer; Internal medicine; Chemotherapy; Oncology; Regimen; Performance status; Mucositis; Induction chemotherapy; Cancer; Surgery; Histone deacetylase; Biology; Histone","score_opus":0.0150066062739379,"score_gpt":0.30320357760859734,"score_spread":0.28819697133465944,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2074077730","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9932995,0.0015753282,0.00032622123,0.0007166256,0.00018386275,0.0010300197,0.001445881,0.00010453709,0.0013179525],"genre_scores_gemma":[0.98306966,0.0027773527,0.0015580785,0.00122796,0.0002900943,0.0016140628,0.005082017,0.000049963037,0.004330957],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9996308,0.00017866406,0.00001473609,0.000059822654,0.000024710898,0.0000911963],"domain_scores_gemma":[0.9991272,0.000096890995,0.00012742885,0.00006103086,0.00003367264,0.0005537823],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013689805,0.00208435,0.0028751462,0.00048697248,0.0004713646,0.0009210409,0.0010616381,0.0013711244,0.0041123307],"category_scores_gemma":[0.0007252908,0.0006339309,0.0018944488,0.0005856714,0.001222596,0.0008032229,0.00043967395,0.0036592642,0.0012248678],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.85513365,0.03381192,0.008348008,0.00047752907,0.001727502,0.00031927516,0.00023357979,0.0027813227,0.025941733,0.00023533503,0.005691161,0.06529902],"study_design_scores_gemma":[0.6952971,0.2839941,0.014782594,0.000023770719,0.00052883325,0.00029726172,0.00007084549,0.0010881925,0.0018003047,0.00016431918,0.0019248308,0.000027909615],"about_ca_topic_score_codex":0.0036829116,"about_ca_topic_score_gemma":0.011560454,"teacher_disagreement_score":0.0041123307,"about_ca_system_score_codex":0.0011873873,"about_ca_system_score_gemma":0.0024472938,"threshold_uncertainty_score":0.01375711},"labels":[],"label_agreement":null},{"id":"W2074355872","doi":"10.3899/jrheum.100907","title":"Valproic Acid Suppresses Interleukin-1ß-induced Microsomal Prostaglandin E<sub>2</sub>Synthase-1 Expression in Chondrocytes Through Upregulation of NAB1","year":2011,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Molecular biology; Small interfering RNA; Chromatin immunoprecipitation; Corepressor; Gene silencing; Messenger RNA; Histone deacetylase; Transcription factor; Gene expression; Transcription (linguistics); Transfection; Biology; Promoter; Histone; Biochemistry; Repressor; Gene","score_opus":0.020434434175516075,"score_gpt":0.26142754664997614,"score_spread":0.24099311247446006,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2074355872","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9935535,0.0047550253,0.00064456713,0.00009799507,0.0000563973,0.000020878926,0.00023869498,0.00009179634,0.000541214],"genre_scores_gemma":[0.9937715,0.0029472858,0.0011072236,0.00008708709,0.00003591726,0.00005248476,0.00047138182,0.00002144914,0.001505656],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998448,0.000027187134,0.000032715943,0.0000224046,0.000038618826,0.000034300894],"domain_scores_gemma":[0.9998903,0.000012803817,0.00004541686,0.000009053068,0.0000152476005,0.00002714987],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483215,0.0005018526,0.0004973794,0.00021575554,0.00012913537,0.00027438585,0.00014154355,0.00019478583,0.00077027484],"category_scores_gemma":[0.00012617272,0.00013113691,0.00028751013,0.00014044074,0.00027295263,0.000144201,0.0001440898,0.0004844924,0.00024967728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00093598856,0.0000712554,0.00022865858,0.00012181931,0.000012440805,0.000054799664,0.000014594197,0.00005371699,0.9968315,0.000019158499,0.000052813124,0.0016032192],"study_design_scores_gemma":[0.00017039277,0.0021340116,0.0099680405,0.00001548571,0.00006515936,0.0002632248,0.00006680897,0.0007225477,0.98401594,0.000032796157,0.0025381185,0.0000075123107],"about_ca_topic_score_codex":0.00049511384,"about_ca_topic_score_gemma":0.000948935,"teacher_disagreement_score":0.00077027484,"about_ca_system_score_codex":0.00020796042,"about_ca_system_score_gemma":0.00028923532,"threshold_uncertainty_score":0.002576828},"labels":[],"label_agreement":null},{"id":"W2074687765","doi":"10.1073/pnas.250494697","title":"Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Cancer Institute; Foundation for Promotion of Cancer Research; Memorial Sloan-Kettering Cancer Center","keywords":"HDAC4; MAPK/ERK pathway; Kinase; Cell biology; Biology; Signal transduction; Chromatin remodeling; Histone deacetylase; Protein kinase A; Histone deacetylase 5; c-Raf; Molecular biology; Histone; Chemistry; Biochemistry; Mitogen-activated protein kinase kinase","score_opus":0.014204765678645679,"score_gpt":0.27342638255906904,"score_spread":0.25922161688042333,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2074687765","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9760125,0.013441677,0.0037174642,0.0003882503,0.0001094962,0.000034264587,0.00046163856,0.00024754147,0.0055872393],"genre_scores_gemma":[0.9815438,0.0046346164,0.0014414327,0.0000724877,0.00003744876,0.000039133505,0.0016257532,0.000024139063,0.010581197],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998072,0.00002346877,0.000012196427,0.000039892646,0.00006752914,0.000049714105],"domain_scores_gemma":[0.9999006,0.0000064077863,0.000039881197,0.000009712531,0.000015335052,0.000027927215],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000106570944,0.0006607493,0.00017418887,0.00047727118,0.00032714268,0.00036539402,0.00021593976,0.00020398344,0.0015166698],"category_scores_gemma":[0.00016526844,0.00030741817,0.00035071484,0.00037645048,0.00020043863,0.00017039297,0.00041488287,0.00030258167,0.00096332293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017819522,0.00002929472,0.0016345106,0.000049417522,0.000024428151,0.00019224732,0.000012319861,0.000058984155,0.99421614,0.00018715455,0.00022777132,0.0031895004],"study_design_scores_gemma":[0.000050767023,0.0001694377,0.06765439,0.000014048506,0.000076283184,0.0013490927,0.00006317359,0.0012868339,0.9067394,0.00024934558,0.022335501,0.000011674422],"about_ca_topic_score_codex":0.001042828,"about_ca_topic_score_gemma":0.0014274966,"teacher_disagreement_score":0.0015166698,"about_ca_system_score_codex":0.0006601287,"about_ca_system_score_gemma":0.00022133894,"threshold_uncertainty_score":0.005073786},"labels":[],"label_agreement":null},{"id":"W2076333986","doi":"10.1038/nrd3674","title":"Epigenetic protein families: a new frontier for drug discovery","year":2012,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1308,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ontario Genomics Institute; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Pfizer; Eli Lilly and Company","keywords":"Epigenetics; Druggability; Bromodomain; Drug discovery; Biology; Histone; Computational biology; DNA methylation; Epigenomics; Genetics; Histone methyltransferase; Methyltransferase; Methylation; Gene; Biochemistry; Gene expression","score_opus":0.02728672238237669,"score_gpt":0.3438968930108087,"score_spread":0.31661017062843205,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076333986","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009718866,0.9966515,0.000801992,0.00081365835,0.00038207587,0.0000036005326,0.000023604507,0.00001983404,0.0012067201],"genre_scores_gemma":[0.00093738467,0.99643075,0.00065682596,0.00057145784,0.00048848504,0.000008057017,0.00004728445,0.0000024554945,0.00085723505],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99976796,0.000039903258,0.000020837217,0.000039279443,0.00010500483,0.000026999664],"domain_scores_gemma":[0.99958545,0.00022086642,0.00004604101,0.000018522429,0.00008670255,0.00004240356],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00077492744,0.001177126,0.001974976,0.0016694028,0.0003867139,0.0014713642,0.0013023689,0.0017091972,0.003761543],"category_scores_gemma":[0.0006928143,0.00043064557,0.0005125338,0.0022516276,0.001289243,0.0024996009,0.0009948674,0.0029341818,0.002598197],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000093858434,0.00005179323,0.00018362646,0.005981761,0.00010752429,0.0002421494,0.00003241836,0.00049736723,0.0037576542,0.016068622,0.059912235,0.91307104],"study_design_scores_gemma":[0.000029450137,0.000038535258,0.00024224943,0.0005039973,0.00006202983,0.00071647286,0.000025253392,0.00015709669,0.00073722587,0.007128562,0.99034405,0.000015138652],"about_ca_topic_score_codex":0.000743265,"about_ca_topic_score_gemma":0.0018119386,"teacher_disagreement_score":0.003761543,"about_ca_system_score_codex":0.0011690363,"about_ca_system_score_gemma":0.0010312654,"threshold_uncertainty_score":0.012583554},"labels":[],"label_agreement":null},{"id":"W2076669786","doi":"10.1074/jbc.m301922200","title":"Functional Characterization of an Amino-terminal Region of HDAC4 That Possesses MEF2 Binding and Transcriptional Repressive Activity","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Terminal (telecommunication); Genetics; Biology; Cell biology; Computer science","score_opus":0.04387251880284638,"score_gpt":0.2834245140716459,"score_spread":0.23955199526879956,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076669786","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99370086,0.0007944497,0.003387779,0.000074785894,0.00002093069,0.000031896172,0.0010255234,0.0000261384,0.00093756645],"genre_scores_gemma":[0.9798006,0.0009105241,0.00801447,0.00008261911,0.000025853906,0.00007507183,0.0074221184,0.00006547539,0.0036033057],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999045,0.000019387764,0.000010478822,0.000014991621,0.000029434583,0.00002115065],"domain_scores_gemma":[0.9998204,0.000045370263,0.000048728085,0.000021919777,0.000022704926,0.00004094306],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018563506,0.00040128687,0.00022480122,0.00017438448,0.00017146098,0.00021369553,0.00030797758,0.00024780966,0.0014972906],"category_scores_gemma":[0.00018801636,0.00016581824,0.0004484684,0.00017409837,0.00022537743,0.00015371315,0.00014288197,0.00042301306,0.0009088733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000059671038,0.000021001972,0.00013411997,0.000022608046,0.0000049883774,0.000027754852,0.0000046951695,0.000079215206,0.99922013,0.000045061228,0.000010846662,0.00036990078],"study_design_scores_gemma":[0.00003778166,0.00019947614,0.008068029,0.0000062911995,0.000033877986,0.00048628697,0.000021043688,0.0013056969,0.9854871,0.000043800712,0.0043028747,0.000007811662],"about_ca_topic_score_codex":0.000898601,"about_ca_topic_score_gemma":0.0007983472,"teacher_disagreement_score":0.0014972906,"about_ca_system_score_codex":0.0004904696,"about_ca_system_score_gemma":0.0002846045,"threshold_uncertainty_score":0.005008936},"labels":[],"label_agreement":null},{"id":"W2077715783","doi":"10.1016/j.bmcl.2008.12.045","title":"Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre; Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; HDAC6; Moiety; Gene isoform; Selectivity; Histone deacetylase; Stereochemistry; Piperazine; Small molecule; Biochemistry; Histone; Gene; Organic chemistry; Catalysis","score_opus":0.015080435497990458,"score_gpt":0.24789012986160378,"score_spread":0.23280969436361332,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2077715783","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82800984,0.019555787,0.06502649,0.0018816032,0.0015311061,0.0006006686,0.0027391857,0.0019619858,0.07869329],"genre_scores_gemma":[0.95462275,0.008086347,0.016014159,0.00056067423,0.0001536912,0.00013834443,0.0010481474,0.00010499166,0.01927071],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999008,0.000011793912,0.000005885446,0.000016690106,0.00002324414,0.000041653446],"domain_scores_gemma":[0.99995565,0.000005078372,0.000009456708,0.0000048406246,0.0000069084094,0.000018052877],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024470573,0.00052486744,0.00045727493,0.00025888905,0.0002160489,0.00034028545,0.0006254998,0.00028016182,0.0041103647],"category_scores_gemma":[0.000114949486,0.00018003452,0.00021044296,0.00026347133,0.00018154822,0.00030011148,0.0003043375,0.0007661526,0.0010996667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008748532,0.00023609391,0.0003381931,0.00027739795,0.000049308488,0.000340372,0.00005036538,0.0014469555,0.92999583,0.0060638045,0.0034142453,0.056912586],"study_design_scores_gemma":[0.00034051307,0.0010450251,0.0005584496,0.000011051704,0.000046140998,0.0004837253,0.000019688476,0.0025908747,0.96333176,0.0005067914,0.031039478,0.000026618876],"about_ca_topic_score_codex":0.00054514356,"about_ca_topic_score_gemma":0.0019680236,"teacher_disagreement_score":0.0041103647,"about_ca_system_score_codex":0.00049962936,"about_ca_system_score_gemma":0.00026286012,"threshold_uncertainty_score":0.013750553},"labels":[],"label_agreement":null},{"id":"W2078074992","doi":"10.1371/journal.pone.0103050","title":"A Meta-Analysis Approach for Characterizing Pan-Cancer Mechanisms of Drug Sensitivity in Cell Lines","year":2014,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Vancouver General Hospital","funders":"","keywords":"Biology; Drug resistance; Cancer; Cancer research; Population; Panobinostat; Histone deacetylase; Genetics; Bioinformatics; Histone; Medicine; Gene","score_opus":0.15544394004279666,"score_gpt":0.33863836881209847,"score_spread":0.1831944287693018,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078074992","genre_codex":"methods","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.25390086,0.097854964,0.6107839,0.0036000952,0.0016600275,0.0023206538,0.024079775,0.0032782988,0.0025213822],"genre_scores_gemma":[0.8991346,0.0040748864,0.08700236,0.0007841219,0.00027471638,0.0026363432,0.00502752,0.00027470014,0.0007907634],"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","domain_scores_codex":[0.94974184,0.03751971,0.0027591602,0.0070322226,0.0022718082,0.0006752768],"domain_scores_gemma":[0.9235208,0.06331003,0.0027128966,0.008913579,0.0010061113,0.00053656165],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.052678555,0.002538054,0.0089040585,0.007831124,0.00078655704,0.0030887066,0.0036587669,0.0021355848,0.0028091713],"category_scores_gemma":[0.053896748,0.0012372973,0.02895397,0.006866821,0.0006706492,0.0014981063,0.0021196483,0.0031905763,0.00028804073],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0050666817,0.000113083996,0.11878717,0.0042895474,0.77054703,0.0007306041,0.00015212705,0.061707366,0.005417221,0.0042629032,0.003298962,0.025627289],"study_design_scores_gemma":[0.0011899213,0.0023395894,0.06223274,0.00052023685,0.53506804,0.00091778574,0.00033687695,0.3527111,0.005633665,0.025902582,0.012805245,0.0003422337],"about_ca_topic_score_codex":0.0053929477,"about_ca_topic_score_gemma":0.0039276057,"teacher_disagreement_score":0.052678555,"about_ca_system_score_codex":0.0014991966,"about_ca_system_score_gemma":0.0017162471,"threshold_uncertainty_score":0.27859414},"labels":[],"label_agreement":null},{"id":"W2078199021","doi":"10.1074/jbc.m102176200","title":"Pho23 Is Associated with the Rpd3 Histone Deacetylase and Is Required for Its Normal Function in Regulation of Gene Expression and Silencing in Saccharomyces cerevisiae","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"National Institute of General Medical Sciences","keywords":"Histone deacetylase 5; HDAC11; Histone deacetylase; Biology; HDAC4; Histone deacetylase 2; Cell biology; Mutant; Histone; HDAC10; Gene silencing; SAP30; Genetics; Gene","score_opus":0.023106875942164838,"score_gpt":0.27659932945438315,"score_spread":0.25349245351221833,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078199021","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9840454,0.0037562149,0.0061865137,0.00015972539,0.00006499639,0.000036782414,0.0038213823,0.0003513019,0.0015777482],"genre_scores_gemma":[0.98967135,0.0010395921,0.0030978692,0.000040158455,0.000009984872,0.000040917326,0.003601738,0.000109380104,0.0023889295],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986374,0.000011582564,0.00001484493,0.000033755357,0.00005610914,0.000019868123],"domain_scores_gemma":[0.99985945,0.000009386616,0.00004326272,0.0000202889,0.000010038362,0.000057554138],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000752953,0.000704874,0.00036729567,0.0002802243,0.00030439877,0.00046359815,0.0004110777,0.00028061494,0.0014844553],"category_scores_gemma":[0.000121681966,0.00020793681,0.00048492628,0.00033658437,0.00029598307,0.00018225746,0.0005475826,0.00039521293,0.0011314022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000083431725,0.00001090785,0.00040927992,0.00004307877,0.00001263454,0.00028168334,0.000010257458,0.00011647164,0.9978409,0.000065907654,0.000050528288,0.0010749197],"study_design_scores_gemma":[0.000024744235,0.00008857703,0.021731272,0.000014631073,0.000030691586,0.0011344826,0.00006211304,0.0012119665,0.96875405,0.00013503706,0.0067902226,0.000022208867],"about_ca_topic_score_codex":0.0025152483,"about_ca_topic_score_gemma":0.0031343054,"teacher_disagreement_score":0.0025152483,"about_ca_system_score_codex":0.0005402394,"about_ca_system_score_gemma":0.0003145528,"threshold_uncertainty_score":0.005001247},"labels":[],"label_agreement":null},{"id":"W2078619188","doi":"10.1074/jbc.m003106200","title":"Rapid Induction of Histone Hyperacetylation and Cellular Differentiation in Human Breast Tumor Cell Lines following Degradation of Histone Deacetylase-1","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Trichostatin A; Histone deacetylase; Quinidine; Cell cycle; Chemistry; Cancer research; Histone deacetylase inhibitor; Cell growth; Lactacystin; Apoptosis; Cell biology; Molecular biology; Biology; Histone; Pharmacology; Proteasome inhibitor; Biochemistry","score_opus":0.017666464458897937,"score_gpt":0.2882538401187697,"score_spread":0.2705873756598718,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078619188","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98433614,0.009568827,0.002619523,0.00008761196,0.000044024957,0.000055928525,0.0013225359,0.00011553756,0.0018499306],"genre_scores_gemma":[0.99027425,0.0026895064,0.0019332992,0.00005379643,0.000010997515,0.000041135085,0.002038814,0.000015985717,0.0029423079],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999026,0.000012060705,0.000010147863,0.00002047742,0.000028687955,0.000025970974],"domain_scores_gemma":[0.9999293,0.000011130388,0.000015625094,0.000012115417,0.000016736201,0.000015160211],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010320432,0.00021408587,0.00020153132,0.00016609262,0.00011669625,0.00015963161,0.00013039439,0.00012804176,0.0012194541],"category_scores_gemma":[0.00007646241,0.00012649279,0.00016638063,0.00016601283,0.00009901742,0.00007846243,0.00010560374,0.0002535818,0.00043587462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000066429064,0.0000073909673,0.00012368486,0.000019244239,0.000002456808,0.000030958952,0.0000071908403,0.000006877126,0.99918634,0.000013963492,0.00002095069,0.0005144115],"study_design_scores_gemma":[0.000006834109,0.00016992359,0.008255774,0.0000026389705,0.000008212161,0.00023447734,0.000013264701,0.00014480253,0.989569,0.0000066811726,0.0015864312,0.0000019390418],"about_ca_topic_score_codex":0.0017104963,"about_ca_topic_score_gemma":0.0031133208,"teacher_disagreement_score":0.0017104963,"about_ca_system_score_codex":0.00032112902,"about_ca_system_score_gemma":0.00015673168,"threshold_uncertainty_score":0.004079461},"labels":[],"label_agreement":null},{"id":"W2078991191","doi":"10.1080/00207450701540062","title":"MEDROXYPROGESTERONE ACETATE INDUCES C6 GLIOMA CHEMOSENSITIZATION VIA ANTIDEPRESSANT-LIKE LYSOSOMAL PHOSPHOLIPIDOSIS/MYELINOSIS<i>IN VITRO</i>","year":2007,"lang":"en","type":"article","venue":"International Journal of Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Phospholipidosis; Pharmacology; Chemistry; Glioma; Programmed cell death; Apoptosis; Cancer research; Biology; Biochemistry; Phospholipid","score_opus":0.014147899636988152,"score_gpt":0.29866389920111674,"score_spread":0.2845159995641286,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078991191","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9940018,0.0018878025,0.0011626782,0.00009018591,0.000035870362,0.000054948243,0.00065716787,0.00011399958,0.0019955349],"genre_scores_gemma":[0.9929374,0.0012697027,0.0016496151,0.000063689826,0.000012618844,0.000055043678,0.0010561766,0.000022290636,0.0029334757],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989235,0.000016472477,0.000011210351,0.000015452662,0.000028476494,0.000035983245],"domain_scores_gemma":[0.99989176,0.000025614378,0.000019760326,0.000019268258,0.000016245536,0.000027395696],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010242685,0.00034830743,0.00027519278,0.00032161496,0.0001414939,0.00017782515,0.0001911885,0.000241282,0.0011579925],"category_scores_gemma":[0.00009199995,0.00013181705,0.00030101155,0.00023807434,0.00013342038,0.00011633149,0.00010550872,0.0004389535,0.0004754136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003781356,0.00010025642,0.00014027164,0.00003996194,0.0000062877552,0.0000837831,0.000018185028,0.000071772716,0.99737275,0.000048632217,0.000059710295,0.0016802213],"study_design_scores_gemma":[0.000016380667,0.0007444771,0.0011727698,0.000001483771,0.000007881868,0.00007539226,0.000007538064,0.00025598053,0.9970247,0.000012286444,0.0006793345,0.0000018258041],"about_ca_topic_score_codex":0.0024482056,"about_ca_topic_score_gemma":0.0034921481,"teacher_disagreement_score":0.0024482056,"about_ca_system_score_codex":0.00029650953,"about_ca_system_score_gemma":0.00020915334,"threshold_uncertainty_score":0.0048679113},"labels":[],"label_agreement":null},{"id":"W2080295983","doi":"10.1210/en.2012-2061","title":"A Positive Regulatory Domain in CCAAT/Enhancer Binding Protein β (C/EBPβ) Is Required for the Glucocorticoid-Mediated Displacement of Histone Deacetylase 1 (HDAC1) from the C/ebpα Promoter and Maximum Adipogenesis","year":2013,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"York University; Health Canada","funders":"Canadian Institutes of Health Research","keywords":"Ccaat-enhancer-binding proteins; HDAC1; Adipogenesis; Glucocorticoid; Internal medicine; Endocrinology; Histone; Histone deacetylase; Chemistry; Biology; Medicine; Transcription factor; Nuclear protein; Gene; Adipose tissue; Biochemistry","score_opus":0.011075370296741627,"score_gpt":0.2831639852483851,"score_spread":0.2720886149516435,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080295983","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98624927,0.003152826,0.007384805,0.00012658497,0.00006956223,0.00006209313,0.0011040501,0.00016214568,0.0016885827],"genre_scores_gemma":[0.99046624,0.00077136874,0.0043744673,0.00007934322,0.000016916361,0.00005139249,0.0021261584,0.00004259182,0.0020715848],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998672,0.000018175533,0.000014119835,0.000041815387,0.00003428472,0.000024371726],"domain_scores_gemma":[0.99982435,0.000028441664,0.000059874423,0.000021004713,0.000013513275,0.000052992607],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012785278,0.0003879102,0.0003452198,0.00015335169,0.00025274084,0.00019905971,0.0003083648,0.00023479844,0.001677554],"category_scores_gemma":[0.0001538636,0.00018971543,0.00034675357,0.00011378119,0.0003322658,0.00012900503,0.00019098098,0.00048490084,0.000988215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006893666,0.000015145295,0.00016993117,0.000028395856,0.000002610836,0.000080977254,0.0000059313675,0.00003586507,0.9988255,0.00006701289,0.000027508695,0.0006721658],"study_design_scores_gemma":[0.000042977834,0.00018432195,0.03262138,0.000013776187,0.000024840807,0.0015867103,0.000034217435,0.0012349484,0.95678437,0.00011788258,0.0073387953,0.000015739324],"about_ca_topic_score_codex":0.001040151,"about_ca_topic_score_gemma":0.0015428123,"teacher_disagreement_score":0.001677554,"about_ca_system_score_codex":0.00040685595,"about_ca_system_score_gemma":0.00033489233,"threshold_uncertainty_score":0.005611956},"labels":[],"label_agreement":null},{"id":"W2080798878","doi":"10.1016/s0006-291x(02)00193-6","title":"Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9)","year":2002,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Hospital for Sick Children; University of Washington; Connaught Fund; National Science Foundation","keywords":"SAP30; Biology; Histone code; Histone methylation; Histone H1; Histone H2A; Molecular biology; Genetics; HDAC4; Histone methyltransferase; HDAC11; Chromatin; Gene; DNA methylation; Gene expression; Nucleosome","score_opus":0.04846980559575498,"score_gpt":0.34717269033012227,"score_spread":0.2987028847343673,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080798878","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96558297,0.004066589,0.013078659,0.0007363841,0.00009970749,0.000049752314,0.006030782,0.00023448773,0.01012078],"genre_scores_gemma":[0.98173094,0.0009445585,0.004109691,0.00011208648,0.00002183473,0.000021114101,0.005059161,0.00005093269,0.00794968],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992406,0.000006090001,0.0000046084087,0.000034817043,0.000015673768,0.000014751396],"domain_scores_gemma":[0.99980694,0.00004158889,0.000052416184,0.000027326312,0.000030296813,0.00004141956],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004689131,0.00013832476,0.0001516093,0.00045278715,0.00037089275,0.00032492742,0.00030219078,0.00030034536,0.0032202548],"category_scores_gemma":[0.00015866525,0.00020637171,0.000282189,0.00036167886,0.00030019763,0.00018761934,0.00028545316,0.00046420484,0.0021616586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040691945,0.000036258043,0.0014229186,0.000047422134,0.000011192974,0.0002021968,0.00003283222,0.0001514927,0.9915411,0.0008830666,0.00020163605,0.005062885],"study_design_scores_gemma":[0.00013591956,0.00039633844,0.2396687,0.000045680354,0.000098385695,0.0018064812,0.00029089733,0.0014655121,0.72000027,0.0015743243,0.03448979,0.000027664131],"about_ca_topic_score_codex":0.0041580284,"about_ca_topic_score_gemma":0.0040450105,"teacher_disagreement_score":0.0041580284,"about_ca_system_score_codex":0.00044604208,"about_ca_system_score_gemma":0.0002638323,"threshold_uncertainty_score":0.010772824},"labels":[],"label_agreement":null},{"id":"W2083385818","doi":"10.1016/j.bcp.2013.08.045","title":"Region-specific cholinergic excitation of layer VI cortical neurons depends on receptor balance and chrna5 expression","year":2013,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph; University of Toronto","funders":"","keywords":"Epigenetics; Methyltransferase; Histone; Histone methyltransferase; Biology; Cholinergic; Cell biology; Neuroscience; Methylation; Genetics; Gene","score_opus":0.020544716720629675,"score_gpt":0.3025234482938669,"score_spread":0.2819787315732372,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083385818","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9919084,0.0014398787,0.0027940245,0.00012218913,0.000034428824,0.000012845056,0.00014855726,0.000052952844,0.003486712],"genre_scores_gemma":[0.9946837,0.0004861569,0.001128623,0.000043527336,0.000008339962,0.000015197189,0.00013092562,0.000032774165,0.0034708234],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998354,0.000016637005,0.000014236234,0.000037572816,0.00003134429,0.00006491493],"domain_scores_gemma":[0.9998388,0.000030689636,0.00003570322,0.000022228585,0.000024329953,0.000048149886],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013953984,0.00027712985,0.00030373232,0.00024050937,0.00019163036,0.0005250548,0.00044137685,0.00027643633,0.0020437478],"category_scores_gemma":[0.00029846028,0.00021467701,0.00029315113,0.00013029421,0.000307675,0.00047591783,0.00036649973,0.0006805339,0.00037579364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010854935,0.000005607208,0.0001469778,0.000013015858,0.0000046241676,0.000015790423,0.000007995584,0.000013958357,0.9988085,0.000076967954,0.000008378014,0.00078951416],"study_design_scores_gemma":[0.000019634204,0.00013948524,0.024061395,0.000012271501,0.000025209181,0.00015841302,0.00010825714,0.00048449286,0.97435683,0.0001063487,0.0005230121,0.000004589007],"about_ca_topic_score_codex":0.0013164375,"about_ca_topic_score_gemma":0.004118043,"teacher_disagreement_score":0.0020437478,"about_ca_system_score_codex":0.0004642106,"about_ca_system_score_gemma":0.00032079732,"threshold_uncertainty_score":0.0068370104},"labels":[],"label_agreement":null},{"id":"W2083656172","doi":"10.1016/j.bbrc.2010.10.085","title":"Histone deacetylase inhibitors mediate post-transcriptional regulation of p21WAF1 through novel cis-acting elements in the 3′ untranslated region","year":2010,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Saskatchewan Cancer Agency","keywords":"Histone deacetylase; Histone deacetylase 5; HDAC11; Untranslated region; HDAC10; Histone deacetylase 2; Histone; Three prime untranslated region; Transcriptional regulation; Biology; Cancer research; HDAC1; Transcription (linguistics); Gene; Cell biology; Gene expression; Messenger RNA; Genetics","score_opus":0.06270832574416298,"score_gpt":0.38114933600438916,"score_spread":0.3184410102602262,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083656172","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9707879,0.005845413,0.01604884,0.00033737492,0.00012182479,0.00005990874,0.00040383867,0.00042414214,0.0059708566],"genre_scores_gemma":[0.99225086,0.00067506765,0.0026148793,0.00009258041,0.00002500781,0.000027309674,0.0003406881,0.000059215366,0.0039144196],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976045,0.000031608735,0.000014324092,0.000055706256,0.00006743177,0.00007053666],"domain_scores_gemma":[0.99976915,0.00008299164,0.0000617051,0.000028053162,0.000026242253,0.000031887073],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003100602,0.0004560348,0.0003070479,0.00026501014,0.00036088857,0.00056968466,0.0003724072,0.0002568161,0.0024246455],"category_scores_gemma":[0.00033459679,0.00034477626,0.0004517307,0.00012876783,0.00041015373,0.00032318558,0.0002296028,0.0008072951,0.0007140988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012846771,0.000017841683,0.00007204476,0.000012621086,0.000003945636,0.000025672845,0.000011593971,0.000056362984,0.9980348,0.00028695152,0.00003465631,0.0013150935],"study_design_scores_gemma":[0.000015786476,0.00005477486,0.0018533568,0.0000018739494,0.000008078852,0.000047223384,0.0000086248465,0.0004148544,0.9964791,0.00008870756,0.0010245175,0.0000030851331],"about_ca_topic_score_codex":0.0010274055,"about_ca_topic_score_gemma":0.0032064738,"teacher_disagreement_score":0.0024246455,"about_ca_system_score_codex":0.0006554074,"about_ca_system_score_gemma":0.00032330732,"threshold_uncertainty_score":0.008111298},"labels":[],"label_agreement":null},{"id":"W2084262863","doi":"10.1074/jbc.m109.045526","title":"Function of Histone Deacetylase 6 as a Cofactor of Nuclear Receptor Coregulator LCoR","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Corepressor; Chromatin immunoprecipitation; Biology; Nuclear receptor; Estrogen receptor alpha; Estrogen receptor; Molecular biology; Gene knockdown; Cell biology; Chromatin; Cancer research; Promoter; Gene expression; Transcription factor; Gene; Genetics","score_opus":0.015981029306632,"score_gpt":0.2964818365774299,"score_spread":0.2805008072707979,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084262863","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97520524,0.009072935,0.009391908,0.0003458162,0.00011380879,0.0000486857,0.0011178324,0.00033364017,0.004370109],"genre_scores_gemma":[0.9867714,0.0017314914,0.003868868,0.000102422615,0.000026650483,0.000018989473,0.0019332059,0.00004694448,0.0054999534],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998456,0.000020970494,0.0000116067695,0.000050926166,0.00003496127,0.000036010093],"domain_scores_gemma":[0.9998871,0.000011301869,0.00002880218,0.000019948804,0.000017842047,0.000034860146],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015377179,0.00035090512,0.00031007468,0.00019592993,0.00020223102,0.00028680405,0.00030917316,0.00018432229,0.0016685065],"category_scores_gemma":[0.000117786934,0.00012757523,0.000390005,0.00015214483,0.00018781998,0.00017136536,0.0003209916,0.00032903536,0.00080025743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001476938,0.000014411028,0.00045880408,0.00004873826,0.000007076752,0.00006238928,0.0000131924335,0.00003195117,0.9970228,0.00019545754,0.000060347116,0.001937035],"study_design_scores_gemma":[0.00002050671,0.00012765155,0.0063241757,0.000006036636,0.000016520402,0.00029243762,0.000022350972,0.00089336175,0.98696923,0.000054836266,0.0052674105,0.000005503527],"about_ca_topic_score_codex":0.0007245094,"about_ca_topic_score_gemma":0.0013880612,"teacher_disagreement_score":0.0016685065,"about_ca_system_score_codex":0.00053323316,"about_ca_system_score_gemma":0.00021047588,"threshold_uncertainty_score":0.0055817366},"labels":[],"label_agreement":null},{"id":"W2084343793","doi":"10.1016/j.celrep.2012.09.016","title":"Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation","year":2012,"lang":"en","type":"article","venue":"Cell Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"HDAC6; Wnt signaling pathway; Progenitor cell; Cancer research; Cell biology; Cancer stem cell; Biology; Downregulation and upregulation; Catenin; Cancer cell; Progenitor; Cancer; Stem cell; Signal transduction; Chemistry; Histone deacetylase; Biochemistry; Genetics; Histone","score_opus":0.009751654235525445,"score_gpt":0.2618046434668822,"score_spread":0.25205298923135677,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084343793","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.985705,0.004262212,0.0038119587,0.00048073215,0.000117671836,0.00004414007,0.00043595277,0.00022537846,0.004916947],"genre_scores_gemma":[0.99334633,0.0013920377,0.0015089783,0.00008311583,0.000020105708,0.000024296745,0.0003751578,0.000020745692,0.0032291855],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998735,0.000014550713,0.000011061463,0.000021162907,0.000039326325,0.00004031944],"domain_scores_gemma":[0.9999386,0.0000062933655,0.000014267253,0.000006940683,0.000008334294,0.000025514226],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012206059,0.0002638884,0.0002496649,0.00019536317,0.00013914536,0.0003781904,0.00018976643,0.00015530872,0.0019530719],"category_scores_gemma":[0.0000944456,0.00015110993,0.00026993276,0.00017864532,0.00021179083,0.00015447322,0.00019100484,0.0006603628,0.00051342475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000101201964,0.000042028114,0.0002182236,0.000029023315,0.0000073022143,0.000030243262,0.000007867239,0.00006774011,0.9969668,0.00021856853,0.00014601949,0.002165],"study_design_scores_gemma":[0.000033889886,0.00014984251,0.0029190388,0.0000033508522,0.000013862219,0.00011618865,0.000017486893,0.0010751561,0.99011457,0.00007307026,0.005480905,0.000002603355],"about_ca_topic_score_codex":0.00076165964,"about_ca_topic_score_gemma":0.0020644895,"teacher_disagreement_score":0.0019530719,"about_ca_system_score_codex":0.0004000638,"about_ca_system_score_gemma":0.00032749466,"threshold_uncertainty_score":0.0065336823},"labels":[],"label_agreement":null},{"id":"W2084433379","doi":"10.3892/or.2012.1758","title":"Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells","year":2012,"lang":"en","type":"article","venue":"Oncology Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"York University","keywords":"Vorinostat; SKP2; Cell cycle; Ubiquitin ligase; Cancer research; Histone deacetylase inhibitor; Biology; Histone deacetylase; Cyclin B1; Cell biology; Ubiquitin; Cancer; Histone; Biochemistry; Cyclin-dependent kinase 1","score_opus":0.015809217755006308,"score_gpt":0.3283152490483627,"score_spread":0.31250603129335636,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084433379","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99409384,0.0031382332,0.0006614375,0.000101318044,0.00002373764,0.000018125418,0.00037839013,0.00008603524,0.0014988945],"genre_scores_gemma":[0.9945093,0.0016787681,0.00065843744,0.000036028487,0.000010752411,0.00003404849,0.0006926104,0.000012730953,0.0023672516],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993217,0.0000090423855,0.000007462868,0.000012031468,0.000024134215,0.0000151711],"domain_scores_gemma":[0.99994934,0.000008502015,0.000015353153,0.0000061287788,0.000008681733,0.0000119330125],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000065410226,0.00027231345,0.00019582456,0.00025558964,0.0001496809,0.0002151444,0.00011858075,0.00013016704,0.0009267631],"category_scores_gemma":[0.000088293404,0.00011730865,0.00015559969,0.0001969768,0.0001344663,0.00011339084,0.00010512248,0.00023480202,0.00027359225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013134004,0.000015334139,0.00008817332,0.000027385848,0.0000032320231,0.00004630346,0.000009381352,0.000036807498,0.9988405,0.000030395524,0.000040056068,0.00073115027],"study_design_scores_gemma":[0.000013805268,0.00016491422,0.0036684724,0.0000026710002,0.000010681475,0.00016370969,0.00001538439,0.0006130753,0.99341846,0.000018888413,0.001907323,0.000002580786],"about_ca_topic_score_codex":0.0010048748,"about_ca_topic_score_gemma":0.0013757233,"teacher_disagreement_score":0.0010048748,"about_ca_system_score_codex":0.00030082365,"about_ca_system_score_gemma":0.00017648091,"threshold_uncertainty_score":0.0031003356},"labels":[],"label_agreement":null},{"id":"W2084538148","doi":"10.1074/jbc.m703549200","title":"Differential Distribution of Unmodified and Phosphorylated Histone Deacetylase 2 in Chromatin","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Strong","keywords":"Chromatin; Histone deacetylase; Differential (mechanical device); Phosphorylation; Chemistry; Histone; Histone deacetylase inhibitor; Acetylation; Cell biology; Cancer research; Biology; Biochemistry; DNA; Physics; Gene","score_opus":0.013821810336949712,"score_gpt":0.28955845093627763,"score_spread":0.2757366405993279,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084538148","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98713046,0.0056796893,0.0038723918,0.00007071717,0.00005700891,0.00002007865,0.0004730367,0.00004677446,0.002649945],"genre_scores_gemma":[0.9941514,0.0012400284,0.0013770342,0.00009085354,0.000021874623,0.00002416216,0.0007369415,0.000016330814,0.002341188],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978715,0.000015284359,0.000014095886,0.000090360954,0.000053816595,0.00003931644],"domain_scores_gemma":[0.9998801,0.000012332293,0.000024857001,0.000013448921,0.000023929288,0.000045241617],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011691633,0.00018932113,0.00016947716,0.00035515038,0.00015392464,0.00032838102,0.00018997754,0.00021343387,0.0018247493],"category_scores_gemma":[0.00012372789,0.00021341941,0.00027780334,0.00022347603,0.00020457029,0.0002709564,0.00029036257,0.0003409159,0.00035742644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000087202905,0.000007193183,0.0011146775,0.00003146507,0.000012896772,0.000047832626,0.000019983772,0.000019888177,0.99723154,0.000079524114,0.000025939173,0.0013217891],"study_design_scores_gemma":[0.000027162054,0.00032725517,0.08897858,0.00001431831,0.00006669237,0.0011957866,0.00012672329,0.000749424,0.90218616,0.00019981903,0.0061113606,0.00001668033],"about_ca_topic_score_codex":0.00045627283,"about_ca_topic_score_gemma":0.000502885,"teacher_disagreement_score":0.0018247493,"about_ca_system_score_codex":0.00021963526,"about_ca_system_score_gemma":0.00012821172,"threshold_uncertainty_score":0.00610435},"labels":[],"label_agreement":null},{"id":"W2087756598","doi":"10.1074/jbc.m511561200","title":"Raf60, a Novel Component of the Rpd3 Histone Deacetylase Complex Required for Rpd3 Activity in Saccharomyces cerevisiae","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Histone deacetylase 5; Histone deacetylase; HDAC11; Acetylation; HDAC4; Biology; Histone; Histone deacetylase 2; Histone H4; Histone acetyltransferase; Molecular biology; Acetyltransferase; Saccharomyces cerevisiae; Biochemistry; SAP30; Yeast; Gene","score_opus":0.05517957539050028,"score_gpt":0.3325984896497511,"score_spread":0.2774189142592508,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2087756598","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98728895,0.0018642705,0.0067665377,0.00011454825,0.000044775294,0.000034603923,0.002345097,0.00037486857,0.0011664553],"genre_scores_gemma":[0.98580223,0.0009124342,0.005783452,0.000048814425,0.000009304844,0.000018984323,0.004990849,0.000060476414,0.0023735138],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999385,0.000004473082,0.000007696303,0.000018776247,0.000022324708,0.000008195275],"domain_scores_gemma":[0.9999399,0.000006205372,0.000016069404,0.000009738346,0.0000065134523,0.000021496331],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006595452,0.00047852664,0.00023195741,0.00023718277,0.00020008958,0.00030700606,0.00021394486,0.00019873277,0.0007737377],"category_scores_gemma":[0.00008661025,0.00015552582,0.00032187047,0.00019115442,0.00015825262,0.00014567368,0.00024248472,0.0002810168,0.0006833154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000054462034,0.000006061393,0.00018531516,0.00002374562,0.0000034543561,0.00009938295,0.000006120082,0.00004620802,0.9984257,0.000044055225,0.00003276658,0.0010726467],"study_design_scores_gemma":[0.000023602446,0.00009894938,0.0121343415,0.000008755746,0.00002776781,0.0010140082,0.00003144825,0.0012622104,0.9791008,0.00013425414,0.0061509362,0.000012883598],"about_ca_topic_score_codex":0.00074765773,"about_ca_topic_score_gemma":0.00092406897,"teacher_disagreement_score":0.0007737377,"about_ca_system_score_codex":0.00035238286,"about_ca_system_score_gemma":0.00016581728,"threshold_uncertainty_score":0.0025883913},"labels":[],"label_agreement":null},{"id":"W2087821811","doi":"10.1038/sj.onc.1207689","title":"Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; American Lebanese Syrian Associated Charities; McMaster University","keywords":"Biology; Trichostatin A; Histone deacetylase; Chromatin immunoprecipitation; Histone deacetylase 2; Molecular biology; HDAC11; Histone deacetylase inhibitor; Chromatin; Histone deacetylase 5; Cyclin-dependent kinase; Cell cycle; Histone; Cancer research; Cell biology; Promoter; Gene expression; Gene; Genetics","score_opus":0.01632846735696494,"score_gpt":0.3070713760925847,"score_spread":0.2907429087356198,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2087821811","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96715784,0.006229397,0.015151337,0.0006387842,0.00042008047,0.000076246826,0.0014349985,0.0005577919,0.008333494],"genre_scores_gemma":[0.9848873,0.0011562668,0.0039255125,0.00011121686,0.00004119402,0.00005205709,0.0012916154,0.00008868901,0.008446184],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996823,0.00004293621,0.000023325676,0.000074640884,0.00006123418,0.00011548705],"domain_scores_gemma":[0.9997242,0.00007653477,0.00005808593,0.000047937647,0.000030740364,0.00006250149],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025011855,0.000509132,0.00035297964,0.0006299387,0.0003725411,0.00044548314,0.00036166213,0.00026431747,0.005078914],"category_scores_gemma":[0.00034108653,0.00034851852,0.00056063914,0.00029600254,0.00042027424,0.00033221228,0.00042749775,0.0009958972,0.0010752954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00055041566,0.00008637796,0.0007213217,0.00007937078,0.000016039294,0.000105823005,0.000024851053,0.00011910761,0.99384993,0.00065600465,0.00025151076,0.0035393238],"study_design_scores_gemma":[0.00002844735,0.00008025203,0.0014857718,0.000004526771,0.000012024557,0.00008663662,0.000024211202,0.0003102754,0.9957105,0.00014834327,0.0021063543,0.000002653111],"about_ca_topic_score_codex":0.0005945145,"about_ca_topic_score_gemma":0.00087934436,"teacher_disagreement_score":0.005078914,"about_ca_system_score_codex":0.0006489633,"about_ca_system_score_gemma":0.00039653797,"threshold_uncertainty_score":0.016990662},"labels":[],"label_agreement":null},{"id":"W2088651611","doi":"10.1371/journal.pone.0073785","title":"HDAC1 and HDAC2 Restrain the Intestinal Inflammatory Response by Regulating Intestinal Epithelial Cell Differentiation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation","keywords":"Biology; Molecular biology; Paneth cell; Histone deacetylase 2; HDAC1; Goblet cell; Cyclin D1; Cancer research; Histone; Cell biology; Histone deacetylase; Cell; Small intestine; Epithelium; Cell cycle; Biochemistry; Gene","score_opus":0.015288687393421633,"score_gpt":0.22250972545229736,"score_spread":0.20722103805887573,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088651611","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95042956,0.026364826,0.009000544,0.00048888207,0.00029357424,0.00012797379,0.0030508558,0.00051777717,0.009726018],"genre_scores_gemma":[0.9716746,0.009235657,0.0051895413,0.00023371093,0.000117159594,0.00016715728,0.0029736825,0.00009203138,0.010316478],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997844,0.000024149134,0.000018215344,0.00005019695,0.0000618321,0.000061106955],"domain_scores_gemma":[0.9999038,0.000006468666,0.000025862846,0.000012378447,0.000015210133,0.00003623086],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018790597,0.0005419948,0.00048432758,0.00038724532,0.00018307519,0.00036350085,0.00027634014,0.00029386496,0.0024052546],"category_scores_gemma":[0.000099947174,0.00019305295,0.0004474717,0.00026509,0.00022557307,0.00018114464,0.0002769803,0.00070822524,0.000662341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031161503,0.000052797746,0.00073142396,0.00016158467,0.000023266182,0.000051455012,0.0000175058,0.000090662055,0.99260217,0.00014221539,0.00028995567,0.005525379],"study_design_scores_gemma":[0.00014297024,0.000990871,0.030471055,0.000031697273,0.00010630221,0.0005680797,0.00007325271,0.0010335724,0.94221044,0.00012422809,0.02423299,0.000014505551],"about_ca_topic_score_codex":0.0005380621,"about_ca_topic_score_gemma":0.001538892,"teacher_disagreement_score":0.0024052546,"about_ca_system_score_codex":0.00024745785,"about_ca_system_score_gemma":0.00026680354,"threshold_uncertainty_score":0.008046389},"labels":[],"label_agreement":null},{"id":"W2090381051","doi":"10.1038/sj.onc.1210599","title":"HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention","year":2007,"lang":"en","type":"review","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1032,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Acetylation; Biology; Histone; Lysine; Histone-modifying enzymes; Histone Acetyltransferases; Genetics; Cell biology; Biochemistry; Gene; Histone H2A; Amino acid","score_opus":0.08860066371805583,"score_gpt":0.3898435425322443,"score_spread":0.30124287881418843,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2090381051","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00010913799,0.99693644,0.00048325167,0.0006699075,0.00067204755,0.0000048512225,0.00001829771,0.000014887457,0.0010911786],"genre_scores_gemma":[0.0007401452,0.99617577,0.0005388372,0.00043822487,0.0004722569,0.000011965164,0.00003812554,0.000002798566,0.0015818559],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99982613,0.00002270579,0.000016918533,0.000030061989,0.000081894446,0.000022350465],"domain_scores_gemma":[0.9997168,0.00012919515,0.000025977988,0.00001281431,0.000081173515,0.000034071854],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00080778636,0.0012303793,0.0017279234,0.0011630318,0.00036178454,0.0011617551,0.0013577654,0.0015825386,0.003276662],"category_scores_gemma":[0.000738771,0.00043024568,0.00036750967,0.0018851497,0.00087965943,0.0017096929,0.0005594997,0.0028067185,0.0031138195],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021411992,0.00008172317,0.00020908503,0.005203953,0.00008456602,0.00023789683,0.000042372038,0.0005611111,0.004175102,0.008813469,0.09292275,0.88745385],"study_design_scores_gemma":[0.000034812903,0.000037001148,0.00030137124,0.00037636823,0.000046679535,0.0006362463,0.000031556952,0.00007667298,0.0008353229,0.0020168964,0.99559575,0.000011303572],"about_ca_topic_score_codex":0.0010830278,"about_ca_topic_score_gemma":0.0029218742,"teacher_disagreement_score":0.003276662,"about_ca_system_score_codex":0.0010409198,"about_ca_system_score_gemma":0.0011394069,"threshold_uncertainty_score":0.010961592},"labels":[],"label_agreement":null},{"id":"W2091873400","doi":"10.1074/jbc.m108364200","title":"Effect of Estradiol on Histone Acetylation Dynamics in Human Breast Cancer Cells","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Research Manitoba","funders":"","keywords":"Histone Acetyltransferases; Acetylation; Histone; SAP30; Histone H2A; Histone methyltransferase; Biology; Chemistry; Biochemistry","score_opus":0.01070365447522609,"score_gpt":0.31483363977331713,"score_spread":0.30412998529809104,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2091873400","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97367996,0.019428177,0.0009949497,0.00019247648,0.000110168134,0.00003292881,0.0015677804,0.00007035473,0.0039231703],"genre_scores_gemma":[0.9778782,0.0105616115,0.0017338262,0.00018421709,0.000035780122,0.000043555432,0.0031991592,0.000025313997,0.0063382243],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999882,0.000023954495,0.000011596105,0.000019588602,0.000030313333,0.000032647873],"domain_scores_gemma":[0.99992526,0.00002756739,0.000008859601,0.000013052,0.000013992634,0.000011374695],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012582442,0.00015316097,0.00028557918,0.00013795093,0.00014650321,0.00024215918,0.00008666866,0.00012624059,0.0016654902],"category_scores_gemma":[0.0001640063,0.000095702955,0.00015709661,0.00028496506,0.00007397191,0.00007951726,0.00010783537,0.00023056871,0.0006047468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012362509,0.00010135743,0.0011250385,0.00008854423,0.000023170485,0.0001450858,0.00006281961,0.000122054305,0.9896372,0.0001093635,0.00033169228,0.007017597],"study_design_scores_gemma":[0.00010488728,0.0010339743,0.013937945,0.000012591821,0.000043748172,0.00029017119,0.000061752326,0.00043711223,0.9710745,0.00004331918,0.012950715,0.000009200573],"about_ca_topic_score_codex":0.0025648617,"about_ca_topic_score_gemma":0.0036409548,"teacher_disagreement_score":0.0025648617,"about_ca_system_score_codex":0.00020292387,"about_ca_system_score_gemma":0.00015355536,"threshold_uncertainty_score":0.0055716634},"labels":[],"label_agreement":null},{"id":"W2091945867","doi":"10.1016/j.bmcl.2013.03.084","title":"A cyclodextrin-capped histone deacetylase inhibitor","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Oxford Nanopore Technologies","keywords":"Chemistry; Vorinostat; Hydroxamic acid; HDAC8; Histone deacetylase; Histone deacetylase inhibitor; Linker; Stereochemistry; HDAC1; Cyclodextrin; Biochemistry; Histone","score_opus":0.0071796158270524225,"score_gpt":0.24823782594463478,"score_spread":0.24105821011758236,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2091945867","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95599943,0.0064361,0.014490142,0.00059426436,0.000694313,0.0001675164,0.0007844413,0.0008386095,0.019995233],"genre_scores_gemma":[0.9853576,0.0019424926,0.0030464837,0.00024248102,0.000026319873,0.00003197486,0.00052165485,0.000022674913,0.008808246],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994254,0.0000047493177,0.000003328624,0.00001698598,0.000012609289,0.000019714344],"domain_scores_gemma":[0.99997616,0.0000033620754,0.0000041512844,0.000003338738,0.000003254275,0.000009735393],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007844245,0.00024710468,0.00021417222,0.00012012125,0.00013316721,0.00022371118,0.0002739099,0.00026076558,0.0015396872],"category_scores_gemma":[0.00007115953,0.0001236233,0.00012079043,0.0001118161,0.0001024037,0.00014648827,0.00012154559,0.00040803262,0.0005196225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048204677,0.000092614246,0.00010139744,0.000065893604,0.000019724148,0.00013016163,0.000008866053,0.00073030044,0.98740375,0.00047973514,0.0008495095,0.0096359635],"study_design_scores_gemma":[0.000053341595,0.00028497825,0.00043763308,0.000003277659,0.000016722859,0.00013441585,0.0000037070606,0.0012579131,0.98988885,0.000044599143,0.007865714,0.000008898205],"about_ca_topic_score_codex":0.0005482111,"about_ca_topic_score_gemma":0.00073470274,"teacher_disagreement_score":0.0015396872,"about_ca_system_score_codex":0.0003215009,"about_ca_system_score_gemma":0.00020622005,"threshold_uncertainty_score":0.0051507354},"labels":[],"label_agreement":null},{"id":"W2092422799","doi":"10.1002/ijc.21383","title":"Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells","year":2005,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Trichostatin A; Sodium butyrate; Histone deacetylase; Biology; Cancer research; LYN; Proto-oncogene tyrosine-protein kinase Src; Oncogene; Src family kinase; Cancer; Cancer cell; Histone; Cell cycle; Kinase; Cell biology; Cell culture; Genetics; Gene","score_opus":0.013440751183279486,"score_gpt":0.3755172660917063,"score_spread":0.36207651490842685,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092422799","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9630586,0.02039459,0.0035571964,0.00072731765,0.00027943606,0.0001952973,0.0033756674,0.0002957446,0.008116218],"genre_scores_gemma":[0.9706937,0.0077562486,0.0025463041,0.0002816928,0.000053052732,0.00022388839,0.0064337966,0.000025929867,0.011985419],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995491,0.00006395032,0.00004506656,0.00007855522,0.00014045389,0.00012284722],"domain_scores_gemma":[0.999881,0.00001476254,0.000019609462,0.000027300934,0.00003002685,0.000027193331],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017733817,0.00039817113,0.00052519,0.0004790873,0.00029484637,0.00033092257,0.00012524087,0.00032533225,0.005337405],"category_scores_gemma":[0.00015713167,0.00019755257,0.0004654122,0.00066092476,0.00016733189,0.00011909885,0.00024866714,0.00073152466,0.0010683826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039438682,0.00008646621,0.00066422066,0.00009501256,0.000021373005,0.00019556725,0.000043796088,0.00006384118,0.99378234,0.00006805516,0.00058562984,0.0039993967],"study_design_scores_gemma":[0.00013796083,0.002051164,0.07680018,0.00002299235,0.00006539213,0.0022801452,0.00018682731,0.0013143922,0.88757163,0.00007537406,0.029475518,0.000018445455],"about_ca_topic_score_codex":0.0027951128,"about_ca_topic_score_gemma":0.0046316874,"teacher_disagreement_score":0.005337405,"about_ca_system_score_codex":0.00035865576,"about_ca_system_score_gemma":0.00037080297,"threshold_uncertainty_score":0.017855465},"labels":[],"label_agreement":null},{"id":"W2092576475","doi":"10.1016/j.gene.2015.02.045","title":"The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review","year":2015,"lang":"en","type":"review","venue":"Gene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":202,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Epigenetics; Biology; Histone; Epigenomics; Chromatin; Acetylation; Epigenetic regulation of neurogenesis; DNA methylation; Histone code; Cancer epigenetics; Histone deacetylase; Histone Acetyltransferases; Histone methylation; Histone methyltransferase; Cell biology; Genetics; Gene expression; DNA; Gene; Nucleosome","score_opus":0.04815908473616127,"score_gpt":0.37536530625314984,"score_spread":0.3272062215169886,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092576475","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00028968,0.9984397,0.00018342865,0.00018723759,0.00016352162,0.0000037068269,0.000043331806,0.000008079008,0.0006813641],"genre_scores_gemma":[0.0011530698,0.99781466,0.00023370114,0.00013928647,0.00011846063,0.000004244233,0.00004491848,0.0000014863563,0.0004901694],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99991405,0.0000093742465,0.000013890221,0.000023407907,0.000029071192,0.000010083422],"domain_scores_gemma":[0.9998584,0.000059040765,0.000029143826,0.0000047959425,0.000035027133,0.000013565953],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026499978,0.0006633369,0.001053224,0.0014453902,0.00020505987,0.000700386,0.0006195377,0.0006645483,0.0028133136],"category_scores_gemma":[0.00040988406,0.0002276642,0.0003921554,0.001568374,0.00030152395,0.00073792174,0.00046692838,0.0009516385,0.001009409],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000301115,0.00009449539,0.0004094176,0.026857281,0.00018644167,0.00032360893,0.000058502214,0.00035903795,0.012685701,0.0027239807,0.021617062,0.9343834],"study_design_scores_gemma":[0.000030255522,0.00017655322,0.0013739899,0.0024138305,0.00033119298,0.0010052552,0.00006844063,0.00009672086,0.003362366,0.0017956928,0.9893177,0.000027995076],"about_ca_topic_score_codex":0.0008983394,"about_ca_topic_score_gemma":0.001784078,"teacher_disagreement_score":0.0028133136,"about_ca_system_score_codex":0.00035149307,"about_ca_system_score_gemma":0.0007685265,"threshold_uncertainty_score":0.009411454},"labels":[],"label_agreement":null},{"id":"W2092861486","doi":"10.1016/j.bmcl.2007.12.057","title":"4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; HDAC1; Acetylation; In vivo; In vitro; Downregulation and upregulation; Chemical synthesis; Histone; Stereochemistry; Biochemistry; Cancer research; Pharmacology; Gene","score_opus":0.010120822950027393,"score_gpt":0.27926724353405774,"score_spread":0.2691464205840303,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092861486","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8919924,0.03724089,0.023879427,0.00075623713,0.0005607472,0.00025482132,0.00060435536,0.00060723646,0.04410391],"genre_scores_gemma":[0.96991426,0.012010509,0.006690139,0.0002656332,0.00013524185,0.00013477048,0.00043137808,0.000032068117,0.0103858905],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998884,0.00002605997,0.000006191368,0.000016288983,0.000025328649,0.000037801638],"domain_scores_gemma":[0.9999559,0.0000062723293,0.000013994691,0.000004558797,0.000006594831,0.000012742967],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020351872,0.0003111962,0.0003402804,0.00019960004,0.00017911948,0.00022445511,0.0006108269,0.00031719657,0.0024574695],"category_scores_gemma":[0.00012139513,0.0001556837,0.00018004964,0.00017441972,0.00017644542,0.0002719326,0.00020695024,0.0004745635,0.0006639014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008091296,0.00024675942,0.00023236965,0.0002780448,0.00002590258,0.0004300184,0.00007087624,0.001462246,0.9569514,0.004100972,0.0011344688,0.03425782],"study_design_scores_gemma":[0.00041225174,0.004303483,0.0025476415,0.000038527713,0.0000717708,0.0010683701,0.000045397388,0.003796286,0.93853855,0.0005111767,0.048621174,0.000045389508],"about_ca_topic_score_codex":0.0006067349,"about_ca_topic_score_gemma":0.0015277141,"teacher_disagreement_score":0.0024574695,"about_ca_system_score_codex":0.0002848583,"about_ca_system_score_gemma":0.00023213639,"threshold_uncertainty_score":0.00822103},"labels":[],"label_agreement":null},{"id":"W2093048712","doi":"10.1038/nature09803","title":"HDACs link the DNA damage response, processing of double-strand breaks and autophagy","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":410,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Optech (Canada)","funders":"National Institute of General Medical Sciences","keywords":"DNA damage; Chromatin; Histone; Cell biology; DNA; Biology; Acetylation; G2-M DNA damage checkpoint; Autophagy; Chemistry; Biochemistry; Cell cycle; Cell cycle checkpoint; Apoptosis; Gene","score_opus":0.014643872706847954,"score_gpt":0.2832595339576823,"score_spread":0.2686156612508343,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093048712","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5586307,0.33529794,0.025776353,0.024728697,0.004223204,0.0002217794,0.002564623,0.000869795,0.047686864],"genre_scores_gemma":[0.8915371,0.07989872,0.0042296257,0.0013526272,0.0010762458,0.000058760324,0.00085084635,0.000048781196,0.020947224],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998741,0.000015287043,0.000008979199,0.000025174384,0.000043168566,0.000033264303],"domain_scores_gemma":[0.9998379,0.00002259438,0.000065612745,0.000018761884,0.000023034876,0.000032166634],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003200727,0.00043245914,0.0002758716,0.00048138993,0.00031319336,0.00088892353,0.00033825843,0.00059407187,0.003516419],"category_scores_gemma":[0.0002443686,0.0003402874,0.0002745002,0.0002798025,0.00053321157,0.00072757597,0.0003824791,0.001107714,0.0007209988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015135069,0.00012900312,0.0013365329,0.0006590875,0.000099136014,0.0003530628,0.000047433437,0.00092027866,0.9275653,0.016127499,0.004434191,0.046814866],"study_design_scores_gemma":[0.00016429079,0.00063982775,0.019800156,0.00008718456,0.00010604771,0.0010561624,0.00014775565,0.0013618075,0.8962655,0.013093434,0.0672451,0.00003261312],"about_ca_topic_score_codex":0.0008369863,"about_ca_topic_score_gemma":0.0019219081,"teacher_disagreement_score":0.003516419,"about_ca_system_score_codex":0.0008464351,"about_ca_system_score_gemma":0.00042626457,"threshold_uncertainty_score":0.011763573},"labels":[],"label_agreement":null},{"id":"W2093248826","doi":"10.1016/j.bmcl.2007.12.009","title":"Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; Stereochemistry; Chemical synthesis; Combinatorial chemistry; In vitro; Histone; Biochemistry","score_opus":0.013417573025702054,"score_gpt":0.27394968836885186,"score_spread":0.2605321153431498,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093248826","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92097515,0.011434071,0.041503333,0.00063299946,0.00042195196,0.0009105643,0.0009891678,0.0005221384,0.022610655],"genre_scores_gemma":[0.9613839,0.006596353,0.021018898,0.00015968092,0.00008321804,0.00034578485,0.0008519593,0.00004941676,0.009510907],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998567,0.000029845034,0.000013272191,0.00002325227,0.000031176223,0.000045758257],"domain_scores_gemma":[0.99992037,0.000007908642,0.000023797207,0.000007004932,0.000016540991,0.000024336094],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030072758,0.00038251793,0.00044990773,0.00022744246,0.00016853557,0.00032801557,0.0007626466,0.00032168394,0.0020107795],"category_scores_gemma":[0.00020847043,0.0002726179,0.0002566492,0.0001946891,0.00019539223,0.00023881273,0.0001986532,0.00045874735,0.0007078599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044551154,0.0001951927,0.00012242602,0.00025498893,0.000026395383,0.0002509548,0.000082329534,0.0019869083,0.9771553,0.002297582,0.0004581326,0.016724108],"study_design_scores_gemma":[0.0004184788,0.0025951436,0.0008545414,0.00002402593,0.000061973,0.00040259337,0.000025928426,0.003054281,0.96944827,0.00017249529,0.02291043,0.000031815132],"about_ca_topic_score_codex":0.00065489,"about_ca_topic_score_gemma":0.0014496931,"teacher_disagreement_score":0.0020107795,"about_ca_system_score_codex":0.00037924876,"about_ca_system_score_gemma":0.00041090595,"threshold_uncertainty_score":0.006726742},"labels":[],"label_agreement":null},{"id":"W2093264973","doi":"10.1158/0008-5472.can-03-2631","title":"The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Fludarabine; Histone deacetylase inhibitor; XIAP; Cancer research; Sodium butyrate; Jurkat cells; Histone deacetylase; Apoptosis; Chemistry; Myeloid leukemia; Programmed cell death; Molecular biology; Biology; Caspase; Histone; Biochemistry; Immunology","score_opus":0.026681745987962146,"score_gpt":0.37270066592405676,"score_spread":0.3460189199360946,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093264973","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9936917,0.0027314925,0.0011563809,0.000083651685,0.00003570762,0.00005162337,0.00021075565,0.00008202151,0.001956803],"genre_scores_gemma":[0.99617237,0.001116971,0.0009182316,0.000051827916,0.000016106223,0.000033876182,0.0004541921,0.000008564751,0.0012278435],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998822,0.00002465106,0.000009622151,0.000015967977,0.00003095659,0.00003655026],"domain_scores_gemma":[0.9999615,0.000007650349,0.000007622173,0.000004651403,0.0000058912733,0.00001277275],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009720814,0.00041404134,0.00037546564,0.00025052403,0.00011743298,0.0002490755,0.00020258845,0.00018041309,0.0012386858],"category_scores_gemma":[0.00008616285,0.00013801818,0.00027891027,0.00020241777,0.00012509848,0.00010811758,0.00018502168,0.0002787072,0.0004375185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00070897915,0.00010323173,0.00039069826,0.0000684288,0.000020806967,0.00011042327,0.000022654802,0.00019778828,0.99486274,0.00007663919,0.00014519351,0.0032924216],"study_design_scores_gemma":[0.00009572331,0.0014024285,0.0042116353,0.0000075072526,0.000051084673,0.00033519583,0.000028183777,0.00078424194,0.988934,0.00001993365,0.0041244323,0.000005556043],"about_ca_topic_score_codex":0.0011266029,"about_ca_topic_score_gemma":0.0022498139,"teacher_disagreement_score":0.0012386858,"about_ca_system_score_codex":0.00036478788,"about_ca_system_score_gemma":0.00027499712,"threshold_uncertainty_score":0.0041437745},"labels":[],"label_agreement":null},{"id":"W2093857954","doi":"10.1371/journal.pone.0038336","title":"Recruitment of Histone Deacetylase 3 to the Interferon-A Gene Promoters Attenuates Interferon Expression","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Canadian Foundation for AIDS Research","keywords":"IRF7; SAP30; HDAC4; Biology; HDAC11; Promoter; Histone deacetylase 5; Molecular biology; Histone deacetylase; HDAC10; Histone; Histone deacetylase 2; HDAC3; Gene expression; Cancer research; Gene; Genetics","score_opus":0.09148239453778827,"score_gpt":0.33578457670670686,"score_spread":0.24430218216891858,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093857954","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9885084,0.0024943992,0.0058460957,0.00019605155,0.0001316573,0.00003716541,0.00074590865,0.00023492266,0.0018054193],"genre_scores_gemma":[0.9934616,0.0007027897,0.002148209,0.00013247397,0.000022188588,0.000045954606,0.0008068215,0.000044366912,0.0026356576],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985576,0.000012905639,0.000014400632,0.000037718233,0.000036896956,0.000042213098],"domain_scores_gemma":[0.99988294,0.000015864467,0.000035161902,0.000015875183,0.00001715116,0.000033013064],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014955876,0.0003663958,0.00030635347,0.00011216402,0.00017102878,0.00028145523,0.00025964077,0.00021855005,0.0026713817],"category_scores_gemma":[0.000106634376,0.00013809097,0.00048173443,0.00009024941,0.00033200046,0.0001631864,0.0002673821,0.0006848204,0.000667538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012841691,0.000014497362,0.00021136903,0.00004193347,0.0000064960304,0.00001252317,0.000005811814,0.000019750267,0.99882823,0.0000338333,0.000032962427,0.0006640216],"study_design_scores_gemma":[0.000022279555,0.00013670666,0.0051486753,0.0000089128625,0.00001954498,0.000069475136,0.000021251111,0.0005993531,0.9919252,0.000049168513,0.0019963381,0.0000033085676],"about_ca_topic_score_codex":0.0006244676,"about_ca_topic_score_gemma":0.0010724401,"teacher_disagreement_score":0.0026713817,"about_ca_system_score_codex":0.00035596642,"about_ca_system_score_gemma":0.00033535284,"threshold_uncertainty_score":0.008936703},"labels":[],"label_agreement":null},{"id":"W2094128461","doi":"10.1210/en.2004-0877","title":"Valproic Acid Inhibits Leptin Secretion and Reduces Leptin Messenger Ribonucleic Acid Levels in Adipocytes","year":2004,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Leptin; Endocrinology; Internal medicine; Lipogenesis; Leptin receptor; Fatty acid synthesis; Energy homeostasis; Fatty acid synthase; Chemistry; Fatty acid; Valproic Acid; Biology; Adipose tissue; Lipid metabolism; Biochemistry; Medicine; Epilepsy; Obesity","score_opus":0.016440047057182168,"score_gpt":0.27965423038291726,"score_spread":0.2632141833257351,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2094128461","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9944178,0.003713614,0.00066751504,0.00010938625,0.00003665284,0.000012614082,0.00015069182,0.000059401245,0.0008324291],"genre_scores_gemma":[0.9944405,0.0029332817,0.0009964734,0.00010101871,0.00001940227,0.000029253142,0.0002994339,0.000024622177,0.0011559292],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989545,0.000026991085,0.000015116733,0.000017686369,0.00002658393,0.00001812099],"domain_scores_gemma":[0.9999256,0.000016199285,0.000024857565,0.000008798659,0.000007121078,0.000017287273],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011090574,0.0002977923,0.0002999982,0.0002538152,0.00014619174,0.00028782853,0.00014797217,0.0002014612,0.0007372301],"category_scores_gemma":[0.00012243794,0.00016925333,0.00021225904,0.000161175,0.0002397127,0.00010921419,0.0001294105,0.0004892873,0.00018192634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006022422,0.00003719083,0.00020906611,0.000037755683,0.000016440668,0.00005046875,0.000013360586,0.00005478195,0.9968534,0.000035278725,0.00003479822,0.002055173],"study_design_scores_gemma":[0.0002517104,0.0022642454,0.008661635,0.000013741274,0.000065267755,0.00049662206,0.000061100094,0.0006912731,0.98454535,0.00010237416,0.0028393327,0.0000073694277],"about_ca_topic_score_codex":0.00065694575,"about_ca_topic_score_gemma":0.0012110833,"teacher_disagreement_score":0.0007372301,"about_ca_system_score_codex":0.0002302844,"about_ca_system_score_gemma":0.00019595156,"threshold_uncertainty_score":0.0024662614},"labels":[],"label_agreement":null},{"id":"W2096367061","doi":"10.1016/s1470-2045(14)70440-1","title":"Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial","year":2014,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":788,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Novartis Pharmaceuticals Corporation; Celgene; Amgen","keywords":"Panobinostat; Bortezomib; Medicine; Dexamethasone; Multiple myeloma; Placebo; Clinical endpoint; Internal medicine; Oncology; Clinical trial; Pathology","score_opus":0.044164886168599204,"score_gpt":0.3379999064510631,"score_spread":0.2938350202824639,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2096367061","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9843789,0.006728339,0.0006546141,0.0012581351,0.0013575638,0.0028517605,0.0010371892,0.00015720488,0.0015763373],"genre_scores_gemma":[0.9816191,0.004670794,0.0015359408,0.0015207722,0.00086868845,0.0033924314,0.0012071374,0.00004199996,0.005143092],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99930644,0.00033696173,0.000038335842,0.00015301997,0.00003933867,0.00012588891],"domain_scores_gemma":[0.9990452,0.0002477147,0.00020821468,0.000070754584,0.000050729373,0.000377413],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018088579,0.0029800648,0.005549759,0.000599483,0.0006367566,0.0014591514,0.0013404697,0.002235497,0.008686832],"category_scores_gemma":[0.0016622712,0.0011522274,0.0030907274,0.0007481135,0.0021481202,0.0016298952,0.0007115466,0.0044329404,0.0015794106],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.99318826,0.0013408557,0.0001245124,0.00026490598,0.00043361788,0.000013660015,0.000022791772,0.00015479379,0.00082943897,0.0000432641,0.00020848622,0.0033753728],"study_design_scores_gemma":[0.97186273,0.02689808,0.00047356306,0.000014954381,0.00023048793,0.000011787163,0.000013612561,0.00014108914,0.000093207644,0.00008340112,0.00016876034,0.000008304907],"about_ca_topic_score_codex":0.0019304428,"about_ca_topic_score_gemma":0.0035191004,"teacher_disagreement_score":0.008686832,"about_ca_system_score_codex":0.0011520688,"about_ca_system_score_gemma":0.00135202,"threshold_uncertainty_score":0.029060364},"labels":[],"label_agreement":null},{"id":"W2096831487","doi":"10.1128/mcb.00853-07","title":"Dephosphorylation and Caspase Processing Generate Distinct Nuclear Pools of Histone Deacetylase 4","year":2007,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Associazione Italiana per la Ricerca sul Cancro","keywords":"Biology; Cell biology; HDAC4; Chromatin; Transcription factor; Histone deacetylase 5; Histone deacetylase; Cell nucleus; Nuclear export signal; Nuclear localization sequence; Programmed cell death; Histone; Psychological repression; Cytoplasm; Biochemistry; Apoptosis; Gene expression","score_opus":0.007403131868375894,"score_gpt":0.28242331826729716,"score_spread":0.2750201863989213,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2096831487","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98685324,0.0010979234,0.0103054615,0.00007853575,0.00003140515,0.000033487147,0.00032905958,0.000073328156,0.0011975786],"genre_scores_gemma":[0.9918127,0.00038565643,0.0050470186,0.000034993416,0.0000073353053,0.000035791196,0.0007661926,0.000026312415,0.0018840285],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997781,0.000027885846,0.000024240539,0.00006417565,0.0000517579,0.000053942564],"domain_scores_gemma":[0.99981946,0.000026089207,0.00006311286,0.000035534384,0.000024288518,0.000031489883],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019721998,0.0004796908,0.00030338328,0.00020821318,0.00013955208,0.00040472698,0.00039899393,0.0002850773,0.0017455211],"category_scores_gemma":[0.0002522079,0.00023006143,0.0006670471,0.00014155151,0.00030490616,0.0003447807,0.0003291828,0.0005591924,0.0005535922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012026372,0.00001234274,0.0003475051,0.000032570802,0.000010133302,0.000044516208,0.000014122696,0.00006951374,0.9979461,0.00033480264,0.000016541095,0.0010516146],"study_design_scores_gemma":[0.000020505593,0.00008353123,0.0029773344,0.000002825946,0.000012165741,0.00019689865,0.000016784896,0.00058889436,0.99497,0.000083802755,0.0010426374,0.0000045596257],"about_ca_topic_score_codex":0.0004202436,"about_ca_topic_score_gemma":0.00043206086,"teacher_disagreement_score":0.0017455211,"about_ca_system_score_codex":0.00053107593,"about_ca_system_score_gemma":0.0002617979,"threshold_uncertainty_score":0.005839348},"labels":[],"label_agreement":null},{"id":"W2096884561","doi":"","title":"Protein Acetylation as an Integral Part of Metabolism in Cancer Development and Progression","year":2014,"lang":"en","type":"article","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Atlantic Cancer Research Institute; National Research Council Canada","funders":"","keywords":"Acetylation; Histone; Cancer; Biology; Biochemistry; Genetics; Gene","score_opus":0.015149861493963487,"score_gpt":0.32705675551603347,"score_spread":0.31190689402207,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2096884561","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.009757855,0.97787285,0.0032191926,0.0016958324,0.000615179,0.000021358608,0.00012523773,0.000052289066,0.006640199],"genre_scores_gemma":[0.067275435,0.9233135,0.0026733868,0.00047666702,0.00060655473,0.000022902874,0.00019293797,0.00001033387,0.005428257],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99980766,0.000039559953,0.000018180153,0.00004240939,0.00006430799,0.000027767726],"domain_scores_gemma":[0.9998927,0.000020349067,0.00002648312,0.0000058846517,0.00003321553,0.000021289548],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033554345,0.0003609627,0.00050426024,0.0006381582,0.00032696495,0.00091306167,0.00033641196,0.0005853809,0.0018946336],"category_scores_gemma":[0.00023162478,0.00013590876,0.00031381924,0.0010720525,0.0004702021,0.00061818736,0.00038232855,0.00078229926,0.0013261454],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007928187,0.00018105491,0.00597045,0.008087249,0.00021616639,0.0015414552,0.00040239145,0.0015160678,0.23249616,0.033117898,0.01742755,0.6982508],"study_design_scores_gemma":[0.000043654887,0.0006030114,0.03038799,0.00093991956,0.00027998353,0.00521834,0.0003072649,0.0008348842,0.08518827,0.015025421,0.8610809,0.00009035889],"about_ca_topic_score_codex":0.00085314695,"about_ca_topic_score_gemma":0.0013215138,"teacher_disagreement_score":0.0018946336,"about_ca_system_score_codex":0.0007167147,"about_ca_system_score_gemma":0.00078461587,"threshold_uncertainty_score":0.0063381195},"labels":[],"label_agreement":null},{"id":"W2097643211","doi":"10.1002/jps.23265","title":"Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)‐b‐poly(dl‐lactic acid) micelle nanocarriers: Characterization and effects on pharmacokinetics in rat serum and urine","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Vorinostat; Micelle; Chemistry; Pharmacokinetics; Nanocarriers; Bioavailability; Solubility; Ethylene glycol; Pharmacology; Nuclear chemistry; Chromatography; Aqueous solution; Organic chemistry; Drug delivery; Histone deacetylase; Biochemistry; Medicine","score_opus":0.013304647855088272,"score_gpt":0.31195304537421154,"score_spread":0.29864839751912325,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2097643211","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.990875,0.0015915304,0.0063087507,0.00011265472,0.00002786061,0.000042848635,0.00016304156,0.00011283191,0.00076559786],"genre_scores_gemma":[0.9949864,0.0006687865,0.0026892337,0.000039442246,0.00001351451,0.000039132166,0.00014801716,0.000037877882,0.0013775595],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999881,0.000020843429,0.000009909437,0.000029912067,0.000032747004,0.000025536467],"domain_scores_gemma":[0.99990404,0.000025326608,0.000027709797,0.000011493066,0.000014594338,0.000016944474],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020382828,0.00025256403,0.00019835887,0.00022380782,0.00016933662,0.00024192334,0.0001558282,0.00024502186,0.00039209297],"category_scores_gemma":[0.00028865517,0.00017172948,0.00021466512,0.00016728738,0.00024541627,0.00033064914,0.00016330378,0.0003484428,0.00018342797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029834476,0.000020222595,0.000076805714,0.000017085418,0.000005502256,0.000036989808,0.000017190772,0.00014870132,0.99665654,0.000056142446,0.000037287708,0.002629264],"study_design_scores_gemma":[0.0000199864,0.00031394736,0.00040672818,0.0000014073653,0.000012125973,0.000068153946,0.000005233831,0.00077400415,0.9978613,0.000017512415,0.00051547185,0.0000040712866],"about_ca_topic_score_codex":0.0011170332,"about_ca_topic_score_gemma":0.0011460563,"teacher_disagreement_score":0.0011170332,"about_ca_system_score_codex":0.00035527162,"about_ca_system_score_gemma":0.00036626853,"threshold_uncertainty_score":0.002577722},"labels":[],"label_agreement":null},{"id":"W2097827010","doi":"10.1093/emboj/cdg218","title":"Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex","year":2003,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; McKnight Foundation","keywords":"Corepressor; HDAC1; Biology; Ccaat-enhancer-binding proteins; Histone deacetylase; Glucocorticoid receptor; Adipogenesis; Histone; Endocrinology; Cell biology; Cellular differentiation; Internal medicine; Glucocorticoid; Nuclear receptor; Molecular biology; Transcription factor; Biochemistry; Nuclear protein; Gene","score_opus":0.02091440960876132,"score_gpt":0.30083710833760857,"score_spread":0.27992269872884723,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2097827010","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9713978,0.0100931525,0.006699634,0.00090134423,0.0002794469,0.00008272939,0.0012624733,0.0003406824,0.0089426385],"genre_scores_gemma":[0.98617655,0.0024146729,0.0021360982,0.00012560045,0.00003998254,0.000029022967,0.00094364514,0.000061008788,0.008073369],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998926,0.000010117362,0.0000070864685,0.000022511089,0.00002725484,0.00004042462],"domain_scores_gemma":[0.999912,0.000012090115,0.0000154651,0.000011320024,0.000011403044,0.000037637565],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014980855,0.00036063732,0.00025650338,0.0002332608,0.00035264512,0.00044623326,0.00024942722,0.00016185093,0.0030925323],"category_scores_gemma":[0.000108556844,0.00022546727,0.00032381076,0.00019143186,0.00027655155,0.00020575125,0.00031649484,0.00074477453,0.0009202329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015648628,0.000011520252,0.00012319151,0.000032137315,0.0000048140387,0.000028804268,0.0000103682205,0.000023286331,0.9979152,0.0001841592,0.000086879634,0.0014232865],"study_design_scores_gemma":[0.00002167138,0.00004717484,0.0035087287,0.0000034158545,0.000008654158,0.000067180365,0.000020679645,0.0001951695,0.99238366,0.00003550161,0.0037052862,0.0000028697305],"about_ca_topic_score_codex":0.0015431554,"about_ca_topic_score_gemma":0.00493949,"teacher_disagreement_score":0.0030925323,"about_ca_system_score_codex":0.0010612195,"about_ca_system_score_gemma":0.00037617856,"threshold_uncertainty_score":0.010345519},"labels":[],"label_agreement":null},{"id":"W2097979965","doi":"10.1021/jm800251w","title":"Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"Pharmacyclics","keywords":"Benzamide; Chemistry; Orally active; Histone deacetylase inhibitor; Histone deacetylase; Stereochemistry; Pharmacology; Biochemistry; Histone; In vitro","score_opus":0.018228492534752148,"score_gpt":0.2979446901774546,"score_spread":0.27971619764270245,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2097979965","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9428644,0.017971912,0.01947813,0.0011789255,0.00024463594,0.00034608573,0.0008844387,0.00041417262,0.01661712],"genre_scores_gemma":[0.97278297,0.009890135,0.008580097,0.00048528865,0.00008099916,0.00011013584,0.0010988159,0.000045158424,0.0069264583],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999516,0.0000075335774,0.000002566593,0.000009846321,0.000013836405,0.000014569527],"domain_scores_gemma":[0.999961,0.0000035079117,0.000011263675,0.0000020594846,0.000008447785,0.00001369124],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011429478,0.0002963089,0.00024621995,0.0001388032,0.0001103978,0.00029207818,0.00037370762,0.00023257438,0.0010006584],"category_scores_gemma":[0.0001115521,0.0001239791,0.00017853308,0.00008782635,0.00015559317,0.00017138073,0.00013109516,0.00041407804,0.0004849919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047048499,0.00019702622,0.0004609357,0.00018198034,0.000016650865,0.0002651925,0.000024271196,0.00072155375,0.96133256,0.001042399,0.0010789122,0.0342081],"study_design_scores_gemma":[0.0006137073,0.004005124,0.003102489,0.0000367967,0.00006296204,0.00123238,0.00002286839,0.0032105404,0.95408463,0.00033457723,0.033275798,0.000018099532],"about_ca_topic_score_codex":0.000832332,"about_ca_topic_score_gemma":0.0018403821,"teacher_disagreement_score":0.0010006584,"about_ca_system_score_codex":0.00042232807,"about_ca_system_score_gemma":0.00038036433,"threshold_uncertainty_score":0.0033475757},"labels":[],"label_agreement":null},{"id":"W2098356010","doi":"10.1038/nm.2661","title":"Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia","year":2012,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":654,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Institute of Cancer Research; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Myeloid leukemia; Cancer research; Acute promyelocytic leukemia; Biology; Leukemia; Tretinoin; Demethylase; Myeloid; Retinoic acid; Immunology; Epigenetics; Cell culture","score_opus":0.008411413880603855,"score_gpt":0.27266795634732527,"score_spread":0.2642565424667214,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2098356010","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9923774,0.0021477358,0.0023441857,0.0002867045,0.00008061463,0.000027120745,0.00034600787,0.00022986312,0.0021604209],"genre_scores_gemma":[0.99579215,0.00081777404,0.0008529572,0.00004577252,0.000009688743,0.000018624352,0.0003329182,0.00001854856,0.0021114748],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998534,0.000025617108,0.000020373722,0.00001867486,0.000037696638,0.000044283883],"domain_scores_gemma":[0.9999181,0.000016717446,0.000020814188,0.000017220831,0.0000067469264,0.000020240963],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003058894,0.00024306499,0.00028686036,0.000274854,0.00019111944,0.00033763595,0.00029910775,0.00017463906,0.0020253747],"category_scores_gemma":[0.00016095031,0.00018957566,0.0002731648,0.00017217973,0.0002953933,0.0001750622,0.00016808779,0.0006535343,0.00047938246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00083050766,0.00012225505,0.0005894289,0.000052538177,0.000024362162,0.000063246895,0.000018195138,0.00038909822,0.98914564,0.0006068144,0.0004141153,0.007743793],"study_design_scores_gemma":[0.000090231144,0.00042769086,0.0021189617,0.0000028663396,0.000022365086,0.00016517226,0.000017391605,0.0008899726,0.99277765,0.0000838444,0.0034002226,0.0000036491654],"about_ca_topic_score_codex":0.00067240925,"about_ca_topic_score_gemma":0.001661201,"teacher_disagreement_score":0.0020253747,"about_ca_system_score_codex":0.00038039987,"about_ca_system_score_gemma":0.00035685225,"threshold_uncertainty_score":0.0067754984},"labels":[],"label_agreement":null},{"id":"W2099771643","doi":"10.1158/0008-5472.can-10-4366","title":"Resuscitating Cancer Immunosurveillance: Selective Stimulation of DLL1-Notch Signaling in T cells Rescues T-cell Function and Inhibits Tumor Growth","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; Genentech; University of Toronto; National Cancer Institute; University of Pennsylvania","keywords":"Immunosurveillance; Immunoediting; Immune system; Cancer; Biology; T cell; Cancer research; Tumor microenvironment; Cell biology; Signal transduction; Immunology; Chemistry; Immunotherapy; Genetics","score_opus":0.04248419755643276,"score_gpt":0.3381845961267093,"score_spread":0.2957003985702765,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2099771643","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9944088,0.0010555339,0.0027898003,0.000121953504,0.000031011325,0.000030923224,0.00020021318,0.00010098351,0.0012606602],"genre_scores_gemma":[0.9960239,0.0004536725,0.0014531065,0.000046507477,0.000008810419,0.000017443215,0.00021780234,0.0000124291255,0.0017663472],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999918,0.000012668403,0.000008047321,0.000018048786,0.000019148976,0.000023945398],"domain_scores_gemma":[0.99995697,0.000005667767,0.000011133085,0.0000054743355,0.0000037435934,0.000017128303],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104792605,0.00026655386,0.0002222737,0.00013921874,0.00010304797,0.00032987996,0.00019373154,0.00018610044,0.0011961506],"category_scores_gemma":[0.00006866963,0.0000835796,0.00015179242,0.00010329382,0.0001823487,0.00014353936,0.00015111842,0.0005635985,0.00029037532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012894595,0.00003610098,0.000104737075,0.00002095203,0.0000040279683,0.000023647215,0.000006811671,0.00008589733,0.99739647,0.00011162641,0.000041857827,0.002038921],"study_design_scores_gemma":[0.00002598975,0.0002569236,0.00035823858,0.0000016061824,0.000010416339,0.00010945871,0.000006326366,0.0005846161,0.9974547,0.000023248389,0.0011671081,0.0000013177767],"about_ca_topic_score_codex":0.00032926633,"about_ca_topic_score_gemma":0.00060171087,"teacher_disagreement_score":0.0011961506,"about_ca_system_score_codex":0.0002734608,"about_ca_system_score_gemma":0.00020707991,"threshold_uncertainty_score":0.004001498},"labels":[],"label_agreement":null},{"id":"W2099792852","doi":"10.1074/jbc.m104935200","title":"Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3in Vivo","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"HDAC4; Corepressor; Histone deacetylase 5; Histone deacetylase; Histone; HDAC11; Cell biology; Chromatin; HDAC3; Biology; Chemistry; Biochemistry; Repressor; Transcription factor; Gene","score_opus":0.026235789586342862,"score_gpt":0.3112170876816244,"score_spread":0.28498129809528155,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2099792852","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94797754,0.014568794,0.018137421,0.0006218123,0.00034059928,0.0000549442,0.0031694453,0.0006635286,0.014465934],"genre_scores_gemma":[0.9538261,0.003395826,0.0066719553,0.000247136,0.00008371644,0.000045956633,0.016777983,0.00020271489,0.018748613],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997372,0.000025686733,0.000012462394,0.000057838162,0.000096084004,0.00007063356],"domain_scores_gemma":[0.9998553,0.00001872551,0.000025105985,0.000029897723,0.00002889965,0.000042063704],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017078206,0.00043584697,0.00026523334,0.000239894,0.0003321046,0.00044801657,0.0003435377,0.00023329463,0.00424912],"category_scores_gemma":[0.0001693644,0.00024674283,0.00045306972,0.00024417343,0.00021479945,0.00014837596,0.00034748358,0.00044717026,0.0040047946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018133456,0.000029565686,0.0012530737,0.00006939722,0.000026037116,0.000077343655,0.000013790042,0.000047260342,0.9934402,0.0004351662,0.00043738674,0.00398937],"study_design_scores_gemma":[0.000029768287,0.00010871045,0.01166225,0.000012982992,0.000033311793,0.00060970767,0.000026961614,0.00091564376,0.9565764,0.00023930341,0.029776333,0.000008617999],"about_ca_topic_score_codex":0.0013387321,"about_ca_topic_score_gemma":0.0022758879,"teacher_disagreement_score":0.00424912,"about_ca_system_score_codex":0.0007941675,"about_ca_system_score_gemma":0.00042076872,"threshold_uncertainty_score":0.014214754},"labels":[],"label_agreement":null},{"id":"W2102296765","doi":"10.1101/gad.170605.111","title":"Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Ellison Medical Foundation","keywords":"Biology; Ubiquitin ligase; Ubiquitin; DNA damage; Histone deacetylase 2; Histone; Acetylation; Cell biology; Null cell; Cancer research; Apoptosis; Histone deacetylase; DNA repair; Epigenetics; DNA; Genetics; Cell culture; Gene","score_opus":0.012942259750289634,"score_gpt":0.24344256751536394,"score_spread":0.2305003077650743,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102296765","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99102,0.002250937,0.004323238,0.00014995167,0.00003134366,0.000016430682,0.00043090427,0.00013506008,0.0016420987],"genre_scores_gemma":[0.996219,0.00045991162,0.0011513949,0.00004408081,0.000005098998,0.000010943675,0.00031269802,0.000022513374,0.0017743683],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998735,0.000016129166,0.0000137830275,0.000034618155,0.000029338638,0.000032575008],"domain_scores_gemma":[0.9998772,0.000018076855,0.000044761,0.000019716892,0.000012308312,0.000027915938],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093678,0.00025376002,0.00024382865,0.0002084279,0.00018403411,0.00042195723,0.00018544028,0.00026436485,0.0016498208],"category_scores_gemma":[0.0001292879,0.00022131212,0.00023556982,0.00009948297,0.00029988727,0.00025643516,0.00024860716,0.00043608964,0.00049654045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000081394355,0.00000820676,0.0002439623,0.000010340575,0.0000025776865,0.000035683777,0.000004311744,0.000021775852,0.9988733,0.000107426,0.000020372432,0.0005905929],"study_design_scores_gemma":[0.00000811821,0.000049909988,0.0038350127,0.000002149799,0.000005232276,0.00021544889,0.000011451262,0.00033761567,0.9942966,0.00005694369,0.0011796538,0.000001914976],"about_ca_topic_score_codex":0.00029702505,"about_ca_topic_score_gemma":0.0005719463,"teacher_disagreement_score":0.0016498208,"about_ca_system_score_codex":0.0003649072,"about_ca_system_score_gemma":0.0001403291,"threshold_uncertainty_score":0.0055192113},"labels":[],"label_agreement":null},{"id":"W2102901106","doi":"10.1002/pbc.24694","title":"A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium","year":2013,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children; Stollery Children's Hospital; Izaak Walton Killam Health Centre; CancerCare Manitoba; Children's Hospital of Western Ontario; Centre Hospitalier Universitaire Sainte-Justine; Western University","funders":"","keywords":"Medicine; Neutropenia; Cmax; Internal medicine; Refractory (planetary science); Pharmacokinetics; Adverse effect; Dosing; Gastroenterology; Chemotherapy","score_opus":0.011246017476387255,"score_gpt":0.3357707622026809,"score_spread":0.3245247447262936,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102901106","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9935313,0.002368708,0.00047658393,0.00033895453,0.000040994495,0.00090665737,0.0009781931,0.00007338474,0.0012853048],"genre_scores_gemma":[0.9812816,0.005702363,0.0036868872,0.00066313514,0.00011508415,0.0020636867,0.0046681794,0.000054761735,0.0017643243],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9997365,0.00013118333,0.000015915286,0.000038680653,0.00003683166,0.000040861887],"domain_scores_gemma":[0.99938,0.000105450905,0.00016073104,0.00003757444,0.000039796734,0.00027639905],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009964866,0.0013902573,0.0013979805,0.0003182701,0.00032656838,0.00056588213,0.0008270753,0.00064986234,0.0022293674],"category_scores_gemma":[0.00050584093,0.0003474488,0.0008473247,0.000556438,0.000738494,0.00041536646,0.0002958595,0.0029631332,0.0004368946],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.48125887,0.0891134,0.04337513,0.00237058,0.0024546045,0.0017979365,0.0009640361,0.009812784,0.10395706,0.0009821785,0.015249616,0.24866377],"study_design_scores_gemma":[0.338898,0.5996775,0.031446796,0.000118140866,0.0009019587,0.0020658881,0.00015058645,0.0028410938,0.015040564,0.00026269353,0.00856257,0.000034234083],"about_ca_topic_score_codex":0.0021229428,"about_ca_topic_score_gemma":0.004941726,"teacher_disagreement_score":0.0022293674,"about_ca_system_score_codex":0.001195446,"about_ca_system_score_gemma":0.0023100665,"threshold_uncertainty_score":0.008673608},"labels":[],"label_agreement":null},{"id":"W2103802459","doi":"10.1161/jaha.112.000901","title":"Histone Deacetylase Activity Selectively Regulates Notch‐Mediated Smooth Muscle Differentiation in Human Vascular Cells","year":2012,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Micromolding Solutions (Canada)","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Notch signaling pathway; Cell biology; Hes3 signaling axis; Protein kinase B; PI3K/AKT/mTOR pathway; Signal transduction; Histone deacetylase; Myosin light-chain kinase; Rho-associated protein kinase; Biology; Cancer research; Histone; Myosin; Biochemistry; Gene","score_opus":0.008712103900291214,"score_gpt":0.28060621540995234,"score_spread":0.27189411150966114,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2103802459","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9886559,0.0058933604,0.00270482,0.00006188035,0.00004465103,0.000037230096,0.0004281802,0.000052797088,0.002121204],"genre_scores_gemma":[0.9939301,0.0018955397,0.0014645507,0.000038665872,0.0000134158145,0.000031161984,0.00072207296,0.000008276065,0.0018962694],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998994,0.000012906891,0.000010728124,0.000028514467,0.00002397937,0.000024537374],"domain_scores_gemma":[0.999962,0.000006018022,0.000009633624,0.000005130784,0.000007586453,0.000009568278],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015358861,0.0001694526,0.00019352735,0.00014552179,0.00011022728,0.00023227942,0.00014576441,0.00013236154,0.0011245314],"category_scores_gemma":[0.00008097242,0.00011277533,0.00022880056,0.00016961814,0.00013253216,0.00007843355,0.000115394934,0.00020066752,0.0002819397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015535542,0.000024142057,0.00041081614,0.000039296116,0.000009452264,0.000029007984,0.000010762855,0.00003370943,0.99705136,0.00006967845,0.00005012895,0.0021161379],"study_design_scores_gemma":[0.000032984557,0.00028076768,0.0076313363,0.000004705136,0.00004209746,0.00018033301,0.000017389515,0.000700842,0.98758775,0.000026507754,0.003492065,0.0000031892941],"about_ca_topic_score_codex":0.0010653827,"about_ca_topic_score_gemma":0.0016897845,"teacher_disagreement_score":0.0011245314,"about_ca_system_score_codex":0.00032759772,"about_ca_system_score_gemma":0.00020250503,"threshold_uncertainty_score":0.0037619472},"labels":[],"label_agreement":null},{"id":"W2104210885","doi":"10.1093/nar/30.5.1114","title":"Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain","year":2002,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Solar Energy Technologies Office; National Cancer Institute","keywords":"HDAC10; HDAC4; Histone deacetylase 5; HDAC11; Biology; Histone deacetylase; Histone deacetylase 2; Cell biology; Cancer research; Genetics; Histone; Biochemistry; Gene","score_opus":0.05034385335626681,"score_gpt":0.3604680162749391,"score_spread":0.3101241629186723,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2104210885","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92736214,0.029349864,0.025314078,0.00095187174,0.00053672236,0.00019432881,0.0034891467,0.00032888877,0.012473052],"genre_scores_gemma":[0.8704102,0.026281476,0.04630047,0.000610889,0.00026312572,0.00011293888,0.023793774,0.000086866276,0.032140147],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993193,0.000005329458,0.0000048522584,0.000020823709,0.000023843191,0.000013195115],"domain_scores_gemma":[0.99991286,0.000006967237,0.000015381376,0.0000052720065,0.000018744598,0.000040799157],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010640634,0.0005798336,0.0002346534,0.00025878297,0.00015837657,0.00029848702,0.00028007876,0.00030599764,0.0014176429],"category_scores_gemma":[0.00012018197,0.00016653824,0.00028385737,0.00018086609,0.00021702483,0.00024496976,0.00020246331,0.0003962177,0.0012815386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017793622,0.000041023137,0.0022432911,0.00021076974,0.000018247272,0.00041987567,0.000020339285,0.000115405644,0.97886366,0.00042878927,0.00073342933,0.016727313],"study_design_scores_gemma":[0.00008719246,0.000544857,0.023001527,0.000044920253,0.00009600843,0.0044467533,0.00007693195,0.0018872848,0.862388,0.00034915117,0.107055426,0.000021918999],"about_ca_topic_score_codex":0.0010488149,"about_ca_topic_score_gemma":0.001642338,"teacher_disagreement_score":0.0014176429,"about_ca_system_score_codex":0.00065867824,"about_ca_system_score_gemma":0.00049164967,"threshold_uncertainty_score":0.004779041},"labels":[],"label_agreement":null},{"id":"W2104588821","doi":"10.1093/abbs/gmr113","title":"Histone acetyltransferases and deacetylases: molecular and clinical implications to gastrointestinal carcinogenesis","year":2011,"lang":"en","type":"review","venue":"Acta Biochimica et Biophysica Sinica","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Histone Acetyltransferases; Acetylation; Histone; Epigenetics; Carcinogenesis; Acetyltransferases; Cancer research; Histone deacetylase; Biology; Genetics; Chemistry; Cancer; DNA; Gene","score_opus":0.05727537565479865,"score_gpt":0.4012807343210787,"score_spread":0.34400535866628,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2104588821","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00011611844,0.9985123,0.00014726684,0.00031831095,0.0002122824,0.000002371587,0.000009790418,0.0000060785565,0.0006754448],"genre_scores_gemma":[0.0006117667,0.99816114,0.00019843249,0.00014673191,0.00020719548,0.0000037152372,0.00001554396,0.0000010467502,0.00065445853],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99988186,0.000018151288,0.000014587836,0.000026649386,0.000044475393,0.000014357454],"domain_scores_gemma":[0.9998173,0.000054850385,0.000024979963,0.000007944019,0.000062657295,0.000032174536],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043199374,0.00077823206,0.0010998589,0.0015963659,0.0003056256,0.0007876119,0.00077859516,0.0012280219,0.002983426],"category_scores_gemma":[0.00045985813,0.00023188288,0.0003318587,0.0022053428,0.0006537872,0.0011475628,0.0006008945,0.0017341601,0.0034872484],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000115876115,0.00007860972,0.00029380037,0.007278415,0.00006571102,0.00037307758,0.00006454523,0.0003226455,0.0062592058,0.00526627,0.032796063,0.9470857],"study_design_scores_gemma":[0.000022250826,0.00008519468,0.0011554267,0.0010989188,0.00006457405,0.0017590492,0.000063547464,0.00007387259,0.001445374,0.003174716,0.99103737,0.000019707237],"about_ca_topic_score_codex":0.0008224554,"about_ca_topic_score_gemma":0.0016384084,"teacher_disagreement_score":0.002983426,"about_ca_system_score_codex":0.0006963239,"about_ca_system_score_gemma":0.00082482985,"threshold_uncertainty_score":0.009980559},"labels":[],"label_agreement":null},{"id":"W2105526739","doi":"10.1371/journal.pone.0018087","title":"HDAC Inhibition Decreases the Expression of EGFR in Colorectal Cancer Cells","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Cancer Research","funders":"National Science Council","keywords":"Cancer research; Epidermal growth factor receptor; Colorectal cancer; Chromatin immunoprecipitation; Protein kinase B; Biology; Cancer cell; Receptor tyrosine kinase; Cancer; Chemistry; Kinase; Phosphorylation; Medicine; Internal medicine; Cell biology; Promoter; Gene expression; Biochemistry","score_opus":0.041550633585813145,"score_gpt":0.2540666120108185,"score_spread":0.21251597842500533,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2105526739","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98281777,0.0073646535,0.0029246986,0.00029278145,0.00021625894,0.00006711374,0.0012149442,0.00028113104,0.004820553],"genre_scores_gemma":[0.98678964,0.0039616786,0.001792702,0.00012416707,0.000027564078,0.00005868963,0.0017080692,0.000029995319,0.0055074925],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998987,0.000010160946,0.000011041295,0.00002013833,0.000028402685,0.00003154125],"domain_scores_gemma":[0.999964,0.000005691232,0.000006970464,0.000006159191,0.000006695073,0.0000105311],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009058653,0.0003913135,0.00042173188,0.00023784654,0.00015052807,0.00019388918,0.0002018602,0.00019308517,0.0014494122],"category_scores_gemma":[0.000071920316,0.0001305367,0.0003593815,0.0002442421,0.0001437063,0.00010607759,0.0001082869,0.000508886,0.00045897064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001605477,0.00005929675,0.00017327556,0.000060260016,0.000011324217,0.000029014527,0.000010737628,0.000036998757,0.99648523,0.00007010252,0.00016958444,0.0027335137],"study_design_scores_gemma":[0.000041052677,0.00047077003,0.0039900844,0.0000034187651,0.000032817374,0.00012010291,0.000017775123,0.0005273143,0.99057674,0.000020229538,0.0041961335,0.0000035388487],"about_ca_topic_score_codex":0.0022708252,"about_ca_topic_score_gemma":0.0038413885,"teacher_disagreement_score":0.0022708252,"about_ca_system_score_codex":0.00033311773,"about_ca_system_score_gemma":0.00026584396,"threshold_uncertainty_score":0.0048487186},"labels":[],"label_agreement":null},{"id":"W2105635571","doi":"10.1128/mcb.20.22.8623-8633.2000","title":"Cell Signaling Switches HOX-PBX Complexes from Repressors to Activators of Transcription Mediated by Histone Deacetylases and Histone Acetyltransferases","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Biology; Repressor; Hox gene; Corepressor; Transcription factor; Enhancer; Histone deacetylase; Trichostatin A; Cell biology; Coactivator; Psychological repression; Activator (genetics); Retinoic acid; Histone; Genetics; Gene expression; Gene","score_opus":0.007967738848965749,"score_gpt":0.2528068749694124,"score_spread":0.24483913612044664,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2105635571","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99458694,0.0011260797,0.001974475,0.0000740634,0.000030818912,0.000011212782,0.00014560662,0.000092598406,0.001958171],"genre_scores_gemma":[0.9936698,0.00061679614,0.0012934675,0.00006193841,0.0000122348865,0.000021240669,0.00038624534,0.000023470637,0.0039148857],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977225,0.000023111521,0.000014989325,0.00007000178,0.000052625233,0.000067000896],"domain_scores_gemma":[0.9998987,0.000015077533,0.000028407669,0.000011519581,0.000009802665,0.00003658354],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011405286,0.0002851428,0.00023465318,0.00016526798,0.00018442584,0.000530136,0.00024813757,0.00018314537,0.0016640463],"category_scores_gemma":[0.00011226257,0.0003845906,0.00018861842,0.00013938796,0.000227062,0.00026345777,0.0003519954,0.0005000193,0.0005650258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000063050786,0.000011111966,0.0003027656,0.000012210288,0.0000037755613,0.000024839694,0.000015613788,0.000029564728,0.99838567,0.00023680479,0.00003887011,0.0008756386],"study_design_scores_gemma":[0.000022479146,0.000082734055,0.012274668,0.0000059246668,0.0000123528,0.00014383586,0.00005861623,0.0013892119,0.9829789,0.00012311913,0.0029022275,0.0000059796703],"about_ca_topic_score_codex":0.000508313,"about_ca_topic_score_gemma":0.0011025445,"teacher_disagreement_score":0.0016640463,"about_ca_system_score_codex":0.00054708985,"about_ca_system_score_gemma":0.00021725755,"threshold_uncertainty_score":0.005566776},"labels":[],"label_agreement":null},{"id":"W2105832153","doi":"10.1161/circresaha.110.219345","title":"Temporal and Spatial Regulation of Histone Deacetylase-7 and β-Catenin in Endothelial Cells","year":2010,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Histone deacetylase; Histone; Cell biology; Histone deacetylase 5; Cancer research; Biology; Chemistry; Medicine; Biochemistry; DNA","score_opus":0.029913129981457922,"score_gpt":0.34624622350299383,"score_spread":0.31633309352153594,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2105832153","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5496354,0.044957425,0.008651275,0.33117852,0.026751539,0.00013858464,0.001125132,0.00048859126,0.037073515],"genre_scores_gemma":[0.9095161,0.012060298,0.0033764024,0.030831708,0.013151168,0.00021483214,0.0003978092,0.000075456766,0.030376231],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997693,0.000044495664,0.000025471616,0.00003639452,0.00007336767,0.000050964445],"domain_scores_gemma":[0.9996424,0.00014983381,0.00005107957,0.00004974394,0.000045682096,0.000061251296],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040649596,0.00024295077,0.00040887328,0.00024834537,0.00039392692,0.00071226305,0.0005599489,0.0017281355,0.0025518492],"category_scores_gemma":[0.0008775832,0.00024672635,0.00032892526,0.00021587408,0.0005387238,0.0006682284,0.00020916709,0.0029397698,0.000945365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.009270037,0.0005590361,0.005608375,0.0005322367,0.00012703826,0.01823169,0.00029480812,0.0007784817,0.7830096,0.017272357,0.09521086,0.069105454],"study_design_scores_gemma":[0.0020349515,0.0015605587,0.07475893,0.00012872792,0.0002288409,0.020883225,0.00072062813,0.008135107,0.56724656,0.015932187,0.30824566,0.00012468411],"about_ca_topic_score_codex":0.0007129116,"about_ca_topic_score_gemma":0.0020097797,"teacher_disagreement_score":0.0025518492,"about_ca_system_score_codex":0.001402123,"about_ca_system_score_gemma":0.00023259078,"threshold_uncertainty_score":0.010173202},"labels":[],"label_agreement":null},{"id":"W2106066891","doi":"10.1016/j.bmcl.2007.10.050","title":"N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada); Nicolet Chartrand Knoll (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; Acetylation; HDAC1; In vivo; In vitro; Recombinant DNA; Histone; Biochemistry; IC50; Cancer research; Stereochemistry; Gene; Biology","score_opus":0.010200838211317795,"score_gpt":0.28799909576569765,"score_spread":0.27779825755437987,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2106066891","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8745932,0.043242805,0.03091106,0.0008946519,0.00078217173,0.00026239682,0.0005863847,0.00093888905,0.04778847],"genre_scores_gemma":[0.9627092,0.017149892,0.0066332533,0.0003032508,0.00015671887,0.00014944952,0.00041254834,0.000056311987,0.012429228],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988747,0.000021518092,0.00000615279,0.00001631244,0.000024694906,0.000043780932],"domain_scores_gemma":[0.9999577,0.0000069709386,0.0000126242085,0.0000039093243,0.000007085241,0.000011737893],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023958199,0.00039328134,0.00038026823,0.0002552981,0.00017486967,0.00022465509,0.0005487114,0.00029754004,0.0022136213],"category_scores_gemma":[0.00011941134,0.00017984718,0.00020169896,0.0001707635,0.00015325988,0.00028048144,0.00023441168,0.00048561385,0.0008201727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00056822324,0.00019718624,0.0002132423,0.00027973746,0.000032304444,0.000268529,0.0000700137,0.0010648519,0.96137947,0.0033129381,0.0012959184,0.031317644],"study_design_scores_gemma":[0.00041540852,0.0027792032,0.0028906239,0.000046739657,0.000098281154,0.00063035503,0.000040595452,0.0035737036,0.94346505,0.0004892375,0.045528915,0.00004192393],"about_ca_topic_score_codex":0.00065962656,"about_ca_topic_score_gemma":0.0019100623,"teacher_disagreement_score":0.0022136213,"about_ca_system_score_codex":0.00032593732,"about_ca_system_score_gemma":0.00019196705,"threshold_uncertainty_score":0.0074053407},"labels":[],"label_agreement":null},{"id":"W2107808656","doi":"10.1172/jci42869","title":"BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Weill Cornell Medical College; National Cancer Institute; National Institutes of Health; College of Veterinary Medicine, Cornell University; Memorial Sloan-Kettering Cancer Center; Geoffrey Beene Cancer Research Center; Commonwealth Foundation; Leukemia and Lymphoma Society; Michael Smith Health Research BC; Canadian Institutes of Health Research; Chemotherapy Foundation","keywords":"Biology; Cancer research; BCL6; P300-CBP Transcription Factors; Histone acetyltransferase; Histone deacetylase inhibitor; Histone deacetylase; Molecular biology; Acetylation; B cell; Immunology; Histone; Genetics; Gene; Antibody; Germinal center","score_opus":0.04215585285881388,"score_gpt":0.3809938247419264,"score_spread":0.3388379718831125,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2107808656","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92891544,0.0109101925,0.04432499,0.0005201634,0.00015442482,0.00055954896,0.0011117173,0.00060321315,0.012900236],"genre_scores_gemma":[0.9853078,0.0031446272,0.0077940384,0.00009171858,0.000019733121,0.0001421336,0.00069746614,0.0000342895,0.0027682367],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998989,0.000013139578,0.000007053247,0.000019346026,0.000032578755,0.000029007886],"domain_scores_gemma":[0.9999682,0.0000032621351,0.0000065462555,0.000005201287,0.0000054011016,0.000011486527],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013312798,0.000448983,0.00036004715,0.0002995318,0.00013138037,0.00034460326,0.00044624068,0.00021768032,0.001214564],"category_scores_gemma":[0.000076832686,0.00014396304,0.00025167008,0.00024928837,0.00016955879,0.00020529484,0.00032500207,0.0009071014,0.0005416581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028534836,0.00026188235,0.00034067218,0.00011057518,0.000024282637,0.00012634695,0.000028414011,0.0013342742,0.9724161,0.0014958375,0.00040603476,0.023170112],"study_design_scores_gemma":[0.0002971944,0.0016297441,0.001639735,0.000015607004,0.000090357644,0.00066231034,0.000027316173,0.0059532006,0.9683992,0.0005056528,0.020763861,0.000015819463],"about_ca_topic_score_codex":0.00039550805,"about_ca_topic_score_gemma":0.0011425464,"teacher_disagreement_score":0.001214564,"about_ca_system_score_codex":0.0004028009,"about_ca_system_score_gemma":0.0001948512,"threshold_uncertainty_score":0.0040631294},"labels":[],"label_agreement":null},{"id":"W2108502873","doi":"10.1139/o03-077","title":"<i>SRC</i> gene expression in human cancer: the role of transcriptional activation","year":2004,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Saskatchewan Cancer Agency","keywords":"Proto-oncogene tyrosine-protein kinase Src; Biology; Cancer research; Tyrosine kinase; Signal transduction; Cancer; Oncogene; Cell biology; Cell cycle; Genetics","score_opus":0.015922569203849837,"score_gpt":0.30458843604068886,"score_spread":0.28866586683683904,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2108502873","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009448057,0.99742585,0.0001556499,0.00029077375,0.00032932364,0.0000039528295,0.00001537734,0.000009672568,0.0016748743],"genre_scores_gemma":[0.0006634137,0.9972907,0.00017599539,0.00022481833,0.0002388024,0.0000067441347,0.00002868553,0.0000019353715,0.0013689632],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998312,0.000029317373,0.000018510436,0.00003924636,0.00006720683,0.000014488356],"domain_scores_gemma":[0.99983466,0.00005473079,0.00002102439,0.000009175097,0.00005729489,0.000023101944],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00050393684,0.00087714515,0.0012319654,0.001876674,0.0002527312,0.00087217224,0.0009458443,0.0011075115,0.002895481],"category_scores_gemma":[0.0004985537,0.00025018843,0.00029805448,0.0026905406,0.0007767299,0.0013927746,0.00051727245,0.0014190064,0.004470763],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000976004,0.000044922974,0.0002033432,0.0069884807,0.000046099038,0.00022949192,0.00006596634,0.00038721113,0.0035444396,0.00612235,0.05689565,0.9253745],"study_design_scores_gemma":[0.000012514544,0.000054555876,0.00072946626,0.00081806665,0.000023793158,0.0008175043,0.000031018757,0.000043724685,0.0004915846,0.0018685344,0.9951007,0.00000863831],"about_ca_topic_score_codex":0.0012660288,"about_ca_topic_score_gemma":0.0015392042,"teacher_disagreement_score":0.002895481,"about_ca_system_score_codex":0.00095703953,"about_ca_system_score_gemma":0.00078521157,"threshold_uncertainty_score":0.009686351},"labels":[],"label_agreement":null},{"id":"W2109498048","doi":"10.1124/mol.109.055277","title":"Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer","year":2009,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Head and neck; Apoptosis; Cancer; Head and neck cancer; Cancer research; Medicine; Chemistry; Internal medicine; Biochemistry; Surgery","score_opus":0.020679051642177454,"score_gpt":0.36003267196002087,"score_spread":0.33935362031784344,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2109498048","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86401635,0.11049724,0.0063792034,0.0021578488,0.0005313745,0.00029877533,0.00025513748,0.0002707158,0.015593253],"genre_scores_gemma":[0.96554303,0.026416412,0.0022457521,0.00034217135,0.00013651066,0.00004070283,0.00015201975,0.000018951892,0.005104413],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992526,0.000022085165,0.0000059221484,0.00000835838,0.000014495856,0.000023840323],"domain_scores_gemma":[0.9999207,0.00002091732,0.000015285834,0.000008542033,0.000016413918,0.000018157518],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031521864,0.00023127547,0.0003504381,0.00037924823,0.00029637924,0.00036433624,0.00041488782,0.00046803732,0.0019364789],"category_scores_gemma":[0.00023246463,0.00011508174,0.0003028143,0.0002697182,0.00021320667,0.00020470413,0.00015622811,0.0004462424,0.00040397805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0059801755,0.0005505136,0.0020449625,0.0007792021,0.00007909608,0.001623734,0.00007773721,0.00070216286,0.8152799,0.0009782676,0.0011850577,0.17071924],"study_design_scores_gemma":[0.001247595,0.011808984,0.0072794063,0.000105611725,0.0003221512,0.0028711902,0.00009602962,0.0022530255,0.9421493,0.00032662824,0.031513456,0.000026689258],"about_ca_topic_score_codex":0.0025278593,"about_ca_topic_score_gemma":0.0043499195,"teacher_disagreement_score":0.0025278593,"about_ca_system_score_codex":0.0004487853,"about_ca_system_score_gemma":0.0006041719,"threshold_uncertainty_score":0.006478131},"labels":[],"label_agreement":null},{"id":"W2109537387","doi":"10.1016/j.bmcl.2003.08.083","title":"(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; Acetylation; Histone; Amino acid; In vitro; Histone deacetylase inhibitor; Recombinant DNA; Stereochemistry; Biochemistry; Gene","score_opus":0.010171625611111198,"score_gpt":0.26493804011923106,"score_spread":0.2547664145081199,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2109537387","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9303614,0.019368026,0.014175529,0.00047222318,0.00047689307,0.00017527185,0.0004394738,0.00024000175,0.03429122],"genre_scores_gemma":[0.97634363,0.010708147,0.0045921705,0.00020266784,0.00010744368,0.00008322882,0.0002395497,0.00002940166,0.0076937866],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993825,0.000013600213,0.0000048597917,0.000008134709,0.000012256048,0.000022880875],"domain_scores_gemma":[0.9999416,0.000010820211,0.000014747434,0.000005013845,0.000007717076,0.000020059493],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021126441,0.00037656375,0.0002247442,0.00020457926,0.00011987568,0.00017067706,0.0003226336,0.00029308628,0.0021060389],"category_scores_gemma":[0.0001217472,0.00016632084,0.00017345183,0.0001592532,0.0001623172,0.0003828364,0.00023114472,0.0004930374,0.0007220013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007497879,0.00017644138,0.00019053134,0.0003322073,0.000025452,0.00063998986,0.00012612199,0.0020149017,0.96666247,0.00347305,0.00053897913,0.02506997],"study_design_scores_gemma":[0.00035343764,0.005543309,0.0025046174,0.000072195435,0.000072607094,0.00079336076,0.00007725109,0.0030645994,0.9494675,0.0008590489,0.037153535,0.00003853832],"about_ca_topic_score_codex":0.00022745287,"about_ca_topic_score_gemma":0.00044516538,"teacher_disagreement_score":0.0021060389,"about_ca_system_score_codex":0.00016889737,"about_ca_system_score_gemma":0.00014260785,"threshold_uncertainty_score":0.007045388},"labels":[],"label_agreement":null},{"id":"W2110804935","doi":"10.1158/1535-7163.mct-12-1039","title":"Expression of Leukemia-Associated Fusion Proteins Increases Sensitivity to Histone Deacetylase Inhibitor–Induced DNA Damage and Apoptosis","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Vorinostat; DNA damage; DNA repair; Biology; Cancer research; Histone deacetylase inhibitor; Apoptosis; Downregulation and upregulation; Histone deacetylase; Myeloid leukemia; Cell cycle; Molecular biology; Cell cycle checkpoint; Histone; DNA; Biochemistry; Gene","score_opus":0.016967447127626288,"score_gpt":0.2886146272937587,"score_spread":0.27164718016613243,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2110804935","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.997698,0.00089042814,0.00072329945,0.000037427657,0.00001027702,0.000014084393,0.00011506902,0.000037457616,0.00047390212],"genre_scores_gemma":[0.9978517,0.00047751245,0.0006851965,0.00002034467,0.000005194512,0.000016306825,0.0003211145,0.000006028297,0.00061652187],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998499,0.000019733154,0.000018579403,0.00002944134,0.00004910544,0.000033177294],"domain_scores_gemma":[0.9999044,0.000026834197,0.000029331712,0.0000113534425,0.000008831562,0.000019264678],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013002909,0.00016891604,0.00028097554,0.00017930524,0.0000922059,0.00024265515,0.00009653225,0.00018200354,0.0009500979],"category_scores_gemma":[0.00011292384,0.00008796582,0.00021163942,0.000169727,0.00014994988,0.00016902594,0.00011400024,0.0004044011,0.00015163937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000085257016,0.000035847588,0.00029329036,0.00001309911,0.0000050202743,0.000018955245,0.000009639629,0.000041718267,0.9986186,0.000029671204,0.000016969965,0.00083200383],"study_design_scores_gemma":[0.000019109377,0.00091979874,0.007849679,0.0000032064243,0.000017815517,0.00022437198,0.000027349537,0.0009161555,0.98861957,0.000024791236,0.0013753341,0.0000028166903],"about_ca_topic_score_codex":0.00025382804,"about_ca_topic_score_gemma":0.00031936035,"teacher_disagreement_score":0.0009500979,"about_ca_system_score_codex":0.00023943561,"about_ca_system_score_gemma":0.00010087913,"threshold_uncertainty_score":0.0031784177},"labels":[],"label_agreement":null},{"id":"W2113515838","doi":"10.1111/j.1365-313x.2012.04984.x","title":"<i>Arabidopsis thaliana</i> histone deacetylase 14 (HDA14) is an α‐tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3","year":2012,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Killam Trusts","keywords":"Acetylation; Histone deacetylase; Histone acetyltransferase; Biology; Microtubule; Tubulin; Protein phosphatase 2; Biochemistry; Acetyltransferase; SAP30; HDAC11; Histone deacetylase 5; Protein subunit; Cell biology; Histone; Molecular biology; Phosphorylation; Phosphatase","score_opus":0.022344442018930592,"score_gpt":0.2797621076511253,"score_spread":0.2574176656321947,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2113515838","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.965372,0.006668079,0.017246492,0.00040583833,0.0001086909,0.00007604735,0.0031060195,0.0007464608,0.0062704044],"genre_scores_gemma":[0.9593162,0.0030279693,0.019106701,0.00018902351,0.000034730376,0.00003783406,0.0069971,0.000083808474,0.011206646],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996006,0.000002702367,0.0000023874795,0.000014510468,0.00001240041,0.000007925764],"domain_scores_gemma":[0.9999571,0.0000038695994,0.000013483644,0.0000044091016,0.000008532663,0.00001253351],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000054980632,0.00036766595,0.00019790209,0.0002081725,0.00021864277,0.0002756268,0.00015985918,0.00012558971,0.0012178834],"category_scores_gemma":[0.000066529865,0.0001431782,0.0002536427,0.00021912657,0.00012846319,0.00012349251,0.00011558457,0.00023475545,0.00063420524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000299874,0.0000057933266,0.0005075768,0.000025341376,0.0000062571476,0.0000362027,0.0000025571753,0.00003152264,0.99756986,0.00006868978,0.00008643617,0.0016296966],"study_design_scores_gemma":[0.000008133316,0.00008627666,0.015819028,0.000004081775,0.00001849905,0.00046700542,0.000010276161,0.00040119217,0.9721676,0.00008940417,0.010923224,0.0000052794135],"about_ca_topic_score_codex":0.0030010426,"about_ca_topic_score_gemma":0.004968358,"teacher_disagreement_score":0.0030010426,"about_ca_system_score_codex":0.0006238326,"about_ca_system_score_gemma":0.00022669381,"threshold_uncertainty_score":0.00596714},"labels":[],"label_agreement":null},{"id":"W2114033240","doi":"10.1158/0008-5472.can-08-0092","title":"Histone Deacetylase Inhibitors Reverse SS18-SSX–Mediated Polycomb Silencing of the Tumor Suppressor <i>Early Growth Response 1</i> in Synovial Sarcoma","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vancouver Coastal Health Research Institute; Vancouver General Hospital","funders":"Hokkaido University","keywords":"Romidepsin; Synovial sarcoma; Cancer research; Chromatin remodeling; Biology; Histone deacetylase; Fusion gene; SWI/SNF; Histone; Fusion protein; Gene silencing; Medicine; Sarcoma; Gene; Pathology; Genetics","score_opus":0.027327512351905385,"score_gpt":0.3297181208927174,"score_spread":0.302390608540812,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2114033240","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9936094,0.002236875,0.0015898551,0.00013738444,0.000080385464,0.000066469496,0.000355845,0.00014232672,0.0017813295],"genre_scores_gemma":[0.9930061,0.0018229033,0.0015710331,0.000086661414,0.000024349094,0.00006336343,0.00078777364,0.000022125578,0.0026155761],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990845,0.000016263322,0.000015351574,0.000013043792,0.00002325844,0.000023668414],"domain_scores_gemma":[0.9999362,0.000012568079,0.000018863791,0.000009477678,0.000007709737,0.00001517617],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010403353,0.00032644137,0.0003339935,0.0001814527,0.0000962219,0.0001960809,0.00022931861,0.00015579417,0.0011945456],"category_scores_gemma":[0.00008646196,0.00010830662,0.0002641643,0.00012226596,0.0001698886,0.000109368324,0.0001123506,0.000656279,0.0003781019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021745704,0.0001426042,0.0001775596,0.000051196945,0.00001284568,0.000051869596,0.000011804733,0.000082028106,0.99614006,0.0000666135,0.000105589475,0.0029404224],"study_design_scores_gemma":[0.0000819992,0.0010679256,0.0027083182,0.0000034759526,0.000027709153,0.00023688006,0.00001566111,0.0005785941,0.9923458,0.000023167613,0.002907572,0.0000029332714],"about_ca_topic_score_codex":0.0005542522,"about_ca_topic_score_gemma":0.001232354,"teacher_disagreement_score":0.0011945456,"about_ca_system_score_codex":0.00016873896,"about_ca_system_score_gemma":0.00021700124,"threshold_uncertainty_score":0.003996134},"labels":[],"label_agreement":null},{"id":"W2114610169","doi":"10.1038/mt.2012.265","title":"HDAC Inhibition Suppresses Primary Immune Responses, Enhances Secondary Immune Responses, and Abrogates Autoimmunity During Tumor Immunotherapy","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; University of Ottawa; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Immune system; Oncolytic virus; Biology; Immunology; Histone deacetylase; Immunotherapy; Antigen; Viral vector; Acquired immune system; Cancer research; Innate immune system; Histone","score_opus":0.006207431566576105,"score_gpt":0.24339002847055746,"score_spread":0.23718259690398136,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2114610169","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9908235,0.0032334689,0.0030393857,0.00010923864,0.00008077113,0.00006107977,0.00023251785,0.00016844028,0.0022514588],"genre_scores_gemma":[0.9948879,0.001374713,0.0012720064,0.00006283954,0.00003278164,0.000039500144,0.0002014445,0.00001668113,0.0021121444],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998734,0.00001605279,0.0000122640695,0.000020778727,0.000030009958,0.000047490368],"domain_scores_gemma":[0.99995005,0.000005179734,0.000014171814,0.0000067108585,0.000006154073,0.000017704313],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113501716,0.00041900395,0.00028529126,0.00016074526,0.00008038618,0.000172024,0.00016105332,0.000132469,0.0009887646],"category_scores_gemma":[0.00006502848,0.00008417999,0.00026906122,0.00009726555,0.00017237192,0.00013432866,0.000121272155,0.0005646607,0.0002996852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020909986,0.00006047456,0.00017099125,0.000045141693,0.000007323122,0.000026608337,0.0000058475734,0.00008248907,0.99622357,0.0000573232,0.000057317186,0.0030536663],"study_design_scores_gemma":[0.00003055428,0.000961595,0.0024801611,0.000004561351,0.000027331536,0.0001425206,0.000010492602,0.0005533494,0.99359846,0.00003077023,0.002157177,0.0000029776083],"about_ca_topic_score_codex":0.00033809576,"about_ca_topic_score_gemma":0.0008161211,"teacher_disagreement_score":0.0009887646,"about_ca_system_score_codex":0.00020484824,"about_ca_system_score_gemma":0.00025450144,"threshold_uncertainty_score":0.0033077002},"labels":[],"label_agreement":null},{"id":"W2116548489","doi":"10.1002/chin.200646116","title":"Substituted N‐(2‐Aminophenyl)‐benzamides, (E)‐N‐(2‐Aminophenyl)‐acrylamides and Their Analogues: Novel Classes of Histone Deacetylase Inhibitors.","year":2006,"lang":"en","type":"article","venue":"ChemInform","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Association of Nurses in Oncology","funders":"","keywords":"Chemistry; Histone deacetylase; Combinatorial chemistry; Stereochemistry; Organic chemistry; Medicinal chemistry; Histone; Biochemistry","score_opus":0.011312892903032112,"score_gpt":0.26463622422375177,"score_spread":0.25332333132071966,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2116548489","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5302142,0.29092386,0.051088005,0.0021046416,0.0033644943,0.00064062554,0.0018411144,0.0019815215,0.11784162],"genre_scores_gemma":[0.8433501,0.090331525,0.014761086,0.0007553525,0.0004435371,0.00031582688,0.0010166608,0.00008699814,0.048938766],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999894,0.000025228914,0.0000068279855,0.000020078098,0.000026274582,0.000027617787],"domain_scores_gemma":[0.99994373,0.000008590406,0.000021821817,0.000003853227,0.0000053662725,0.00001662274],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018626414,0.0004951759,0.0002956455,0.00021651266,0.00016115549,0.00022581904,0.0004518644,0.00036892327,0.0048856796],"category_scores_gemma":[0.00014819003,0.00022680839,0.00016877663,0.00018936879,0.00020723279,0.00048643295,0.00017612318,0.00051982416,0.0018610178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006655636,0.00016179428,0.000073596,0.0006095557,0.00003406166,0.00024728343,0.000035167035,0.00057155546,0.9495301,0.0029046182,0.0033077153,0.041858893],"study_design_scores_gemma":[0.00045127707,0.003636112,0.0019042755,0.00006528886,0.00006140806,0.0013363861,0.000040098865,0.001322312,0.89370304,0.00061078457,0.09681257,0.00005640907],"about_ca_topic_score_codex":0.0004011889,"about_ca_topic_score_gemma":0.0011007934,"teacher_disagreement_score":0.0048856796,"about_ca_system_score_codex":0.00026112833,"about_ca_system_score_gemma":0.00021810664,"threshold_uncertainty_score":0.01634419},"labels":[],"label_agreement":null},{"id":"W2117918664","doi":"10.1038/nn.3354","title":"Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation","year":2013,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute on Drug Abuse; National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Nucleus accumbens; Histone deacetylase; Histone; Acetylation; Histone deacetylase 5; Histone methylation; Histone H4; Histone H3; Cell biology; Chemistry; Histone deacetylase 2; Neuroscience; Biology; Pharmacology; Gene expression; Biochemistry; DNA methylation; Dopamine; Gene","score_opus":0.009856245588341004,"score_gpt":0.2894621850847879,"score_spread":0.27960593949644685,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2117918664","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98997164,0.0013121852,0.0025750617,0.0005372066,0.0002937743,0.000078586636,0.00094794575,0.00039552094,0.0038880287],"genre_scores_gemma":[0.9939144,0.0008472662,0.0012935731,0.00010542713,0.000036178837,0.00004554248,0.0003924373,0.00006516172,0.0032999846],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998548,0.000012400879,0.000010255015,0.00003219158,0.000026390622,0.00006395244],"domain_scores_gemma":[0.99988115,0.000012989463,0.000026780423,0.000020849953,0.000010485575,0.00004766016],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162635,0.00046057694,0.00052719365,0.00021695117,0.00025678184,0.0003618242,0.00071362837,0.00034339543,0.0034520796],"category_scores_gemma":[0.00016768312,0.0002462169,0.00037352313,0.00015401289,0.00044110153,0.00031492457,0.00017688304,0.0017942922,0.0006627811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014754437,0.00024950833,0.0002172085,0.000051778254,0.000049972008,0.0000409045,0.000014782675,0.0002223338,0.9894621,0.00048081725,0.00052502856,0.007210079],"study_design_scores_gemma":[0.00024844264,0.0012118286,0.0032669378,0.00000850957,0.000046866684,0.00012462291,0.000028887605,0.0017873612,0.9906041,0.00020412685,0.0024550355,0.000013301796],"about_ca_topic_score_codex":0.002479519,"about_ca_topic_score_gemma":0.011242599,"teacher_disagreement_score":0.0034520796,"about_ca_system_score_codex":0.0007519235,"about_ca_system_score_gemma":0.0005797769,"threshold_uncertainty_score":0.0115484},"labels":[],"label_agreement":null},{"id":"W2118443566","doi":"10.1016/j.schres.2014.09.029","title":"Family-based association study of common variants, rare mutation study and epistatic interaction detection in HDAC genes in schizophrenia","year":2014,"lang":"en","type":"article","venue":"Schizophrenia Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Université de Montréal","funders":"Université de Montréal; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Fondation Pierre Deniker pour la Recherche et la Prévention en Santé Mentale; Ministry of Science and Innovation, New Zealand; Génome Québec; Genome Canada; Fundación Alicia Koplowitz","keywords":"Multifactor dimensionality reduction; Genetics; Epistasis; Gene; HDAC10; Histone deacetylase; Histone; Biology; Single-nucleotide polymorphism; Medicine; Genotype","score_opus":0.02521479498803863,"score_gpt":0.34163745249966454,"score_spread":0.3164226575116259,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2118443566","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.998473,0.00015199534,0.0007451306,0.000022290586,0.0000095785435,0.000008313693,0.00031181946,0.000011927684,0.00026605913],"genre_scores_gemma":[0.99909294,0.000052633928,0.0004085543,0.000012813461,0.000004897119,0.000007463356,0.0001581932,0.000008229618,0.00025426375],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99865544,0.00041239045,0.00016293995,0.0005060338,0.00015376009,0.00010931282],"domain_scores_gemma":[0.9988997,0.0004029698,0.00021006745,0.0001379319,0.00013034978,0.00021893048],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00097181177,0.00063474133,0.0006014414,0.0024814822,0.0014168323,0.00045646034,0.00050532626,0.0004529054,0.0045069424],"category_scores_gemma":[0.0020682574,0.00029590857,0.0012340047,0.0018903319,0.00051476667,0.00028520531,0.0006168522,0.00055114034,0.00034271076],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019551879,0.00028204438,0.940719,0.000052899188,0.0014339619,0.0046325577,0.0011481808,0.00044303483,0.03976009,0.0006373194,0.0005056628,0.00842994],"study_design_scores_gemma":[0.00010111997,0.00049745303,0.98478067,0.000014892228,0.0010155258,0.007187637,0.0006190419,0.0017043536,0.0027242454,0.00028187633,0.0010368578,0.000036275484],"about_ca_topic_score_codex":0.008900298,"about_ca_topic_score_gemma":0.009453863,"teacher_disagreement_score":0.008900298,"about_ca_system_score_codex":0.0003681073,"about_ca_system_score_gemma":0.00046750045,"threshold_uncertainty_score":0.017696977},"labels":[],"label_agreement":null},{"id":"W2118837528","doi":"10.1158/1078-0432.ccr-10-0395","title":"HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth","year":2010,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children","funders":"Bundesministerium für Bildung und Forschung","keywords":"Medulloblastoma; Histone deacetylase 5; Gene knockdown; Cancer research; Biology; Histone deacetylase; Immunology; Oncology; Medicine; Cell culture; Histone; Genetics","score_opus":0.04207828477692169,"score_gpt":0.43113763143858047,"score_spread":0.38905934666165876,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2118837528","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9394894,0.047901504,0.007654134,0.00032951948,0.000068952075,0.000078901576,0.0019120505,0.00018331944,0.0023821737],"genre_scores_gemma":[0.9875557,0.006160417,0.003944261,0.000042414285,0.00004690255,0.00002226587,0.0010861276,0.000010048848,0.0011319453],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998518,0.000019723426,0.000014499132,0.000042832326,0.00004560834,0.000025373973],"domain_scores_gemma":[0.9998678,0.0000141869,0.00006457908,0.0000075262465,0.000021534093,0.000024305056],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023571157,0.0005039061,0.00036262794,0.0007817362,0.00018750077,0.00044650794,0.00023206536,0.00021639523,0.0008565615],"category_scores_gemma":[0.00021829014,0.00014563034,0.0003347375,0.0005238261,0.00024047749,0.00022455162,0.0001916468,0.00035330807,0.00031847134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017482617,0.00008904431,0.20887403,0.0006406644,0.00025685626,0.0005684859,0.00011819316,0.0006636757,0.71243286,0.0003916419,0.0009136571,0.073302574],"study_design_scores_gemma":[0.000043197513,0.0004945075,0.7655903,0.00006946595,0.0003626309,0.0026244556,0.00016435777,0.0035045224,0.21553239,0.00036097606,0.011227211,0.000026019214],"about_ca_topic_score_codex":0.002709071,"about_ca_topic_score_gemma":0.0041877306,"teacher_disagreement_score":0.002709071,"about_ca_system_score_codex":0.00075590255,"about_ca_system_score_gemma":0.0002949588,"threshold_uncertainty_score":0.0054845214},"labels":[],"label_agreement":null},{"id":"W2118993609","doi":"10.2337/db12-1770","title":"Diabetes Induces Lysine Acetylation of Intermediary Metabolism Enzymes in the Kidney","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Acetylation; Lysine; Carbohydrate metabolism; Diabetes mellitus; Gluconeogenesis; Biochemistry; Metabolism; Enzyme; Biology; Citric acid cycle; Amino acid; Internal medicine; Endocrinology; Chemistry; Medicine; Gene","score_opus":0.007242525095806144,"score_gpt":0.24785541181627074,"score_spread":0.2406128867204646,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2118993609","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99528295,0.0020907691,0.0016878041,0.00006606217,0.00002945832,0.0000108460745,0.00023262891,0.000031839798,0.00056776794],"genre_scores_gemma":[0.99646926,0.0013235504,0.0009796848,0.00007136046,0.000008513335,0.00000805905,0.0003870265,0.000008529069,0.0007440471],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998963,0.000011260379,0.00000977169,0.000027671105,0.000029841745,0.00002517823],"domain_scores_gemma":[0.9999182,0.000008498354,0.000029751809,0.000008388778,0.000010014005,0.000025081743],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011932233,0.00025436317,0.00023689079,0.00024736562,0.00017522236,0.0003154769,0.00011511424,0.00018029874,0.0006381451],"category_scores_gemma":[0.0000759795,0.00014448425,0.0003116879,0.00020257456,0.00020763114,0.00015016238,0.00021491274,0.00033039958,0.00015560325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012830595,0.000010246573,0.0014218314,0.000024423225,0.000016333179,0.00005138867,0.0000066444413,0.000014547561,0.9977463,0.000019052435,0.000015740454,0.00054523966],"study_design_scores_gemma":[0.000023040586,0.00031164906,0.19249852,0.000008760512,0.00007461513,0.0006208835,0.000088833825,0.00050311565,0.8041772,0.00009974766,0.0015828322,0.000010908874],"about_ca_topic_score_codex":0.00090622116,"about_ca_topic_score_gemma":0.0015336712,"teacher_disagreement_score":0.00090622116,"about_ca_system_score_codex":0.00021896741,"about_ca_system_score_gemma":0.00020830572,"threshold_uncertainty_score":0.0021348596},"labels":[],"label_agreement":null},{"id":"W2119142674","doi":"10.1158/1535-7163.mct-04-0107","title":"Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2–related protein Bad","year":2005,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Trichostatin A; Histone deacetylase; Histone deacetylase inhibitor; Apoptosis; Cancer research; Cell cycle checkpoint; Biology; Cell cycle; Viability assay; Cell biology; Molecular biology; Chemistry; Histone; Genetics; Gene","score_opus":0.011151770276515777,"score_gpt":0.27048365189860496,"score_spread":0.2593318816220892,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119142674","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9979183,0.00034377107,0.00045739138,0.000044531527,0.00001752095,0.000038360697,0.00027587582,0.000039263574,0.000864987],"genre_scores_gemma":[0.99596006,0.0004855747,0.0008030492,0.000040124265,0.000008073066,0.00007059975,0.00078736135,0.000014491951,0.0018308175],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998988,0.0000134971,0.0000139332205,0.000014015528,0.000030525884,0.000029194185],"domain_scores_gemma":[0.99991,0.000018073137,0.000016923179,0.000017199847,0.000011004479,0.000026816491],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009212961,0.00023214988,0.0002804887,0.00028673213,0.00011991615,0.00017476415,0.0001689858,0.00016839003,0.0010050806],"category_scores_gemma":[0.00011183156,0.00015198185,0.00026744686,0.00026222382,0.00013059011,0.000120947974,0.00012801819,0.00047201544,0.00029208543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018600165,0.00008157762,0.00030601048,0.000020387655,0.000010031945,0.00005657953,0.000020458865,0.000089403955,0.9982222,0.000059045426,0.00007320232,0.0008751383],"study_design_scores_gemma":[0.00006789833,0.0011094235,0.0091480715,0.0000028975685,0.000016157594,0.00021606812,0.000029723209,0.0011980482,0.9867936,0.00003112943,0.001383665,0.0000034024652],"about_ca_topic_score_codex":0.0010415085,"about_ca_topic_score_gemma":0.0016138824,"teacher_disagreement_score":0.0010415085,"about_ca_system_score_codex":0.00027349472,"about_ca_system_score_gemma":0.0002191861,"threshold_uncertainty_score":0.0033623576},"labels":[],"label_agreement":null},{"id":"W2119478924","doi":"10.1200/jco.2007.14.5730","title":"Phase I Study of MGCD0103 Given As a Three-Times-Per-Week Oral Dose in Patients With Advanced Solid Tumors","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Tolerability; Pharmacokinetics; Nausea; Pharmacodynamics; Vomiting; Dosing; Pharmacology; Gastroenterology; Internal medicine; Surrogate endpoint; Anorexia; Bioavailability; Adverse effect","score_opus":0.06328768577893447,"score_gpt":0.45033348611699864,"score_spread":0.3870458003380642,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119478924","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9940963,0.0014796316,0.0007675405,0.00024741315,0.000064880755,0.0014886357,0.0005059643,0.00014061984,0.0012090766],"genre_scores_gemma":[0.991351,0.0011739951,0.0026163615,0.00042966736,0.00009814097,0.0012952447,0.0016544431,0.000033618766,0.0013476341],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99978286,0.00007009271,0.000011252876,0.000045202283,0.000029750789,0.000060831953],"domain_scores_gemma":[0.9995751,0.000057695084,0.000085662374,0.000040379044,0.00002545725,0.00021569456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00066996505,0.001130858,0.0018097104,0.00036750946,0.00038348915,0.0006450622,0.0007791448,0.0008981353,0.0019918745],"category_scores_gemma":[0.0005266706,0.00033742358,0.0007157933,0.0005334683,0.0009799827,0.0003917799,0.00030932116,0.0028997103,0.00064468203],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.44862303,0.09289164,0.019705052,0.0010628896,0.0010666049,0.0007575872,0.0006218346,0.007657093,0.20841792,0.00056877563,0.0077842344,0.21084341],"study_design_scores_gemma":[0.3470681,0.60040414,0.023503862,0.000043763586,0.0002936763,0.00090313517,0.00006038218,0.0024762144,0.019858968,0.0002630964,0.0050908076,0.0000338293],"about_ca_topic_score_codex":0.0012158111,"about_ca_topic_score_gemma":0.0023090248,"teacher_disagreement_score":0.0019918745,"about_ca_system_score_codex":0.0010072672,"about_ca_system_score_gemma":0.0016147017,"threshold_uncertainty_score":0.0073083043},"labels":[],"label_agreement":null},{"id":"W2119558650","doi":"10.4172/2168-9547.1000103","title":"Regulation of Myf5 Early Enhancer by Histone Acetyltransferase P300 during Stem Cell Differentiation","year":2012,"lang":"en","type":"article","venue":"Molecular Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"MYF5; Enhancer; Histone acetyltransferase; Biology; Myogenesis; PCAF; Cell biology; Histone; Acetylation; Induced pluripotent stem cell; Cellular differentiation; Histone H3; Transcription factor; Embryonic stem cell; MyoD; Genetics; Gene; Myocyte","score_opus":0.005268948180898703,"score_gpt":0.26284081226741524,"score_spread":0.25757186408651656,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119558650","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95229816,0.014165078,0.023608193,0.00023104511,0.00007872647,0.00008829064,0.0010795458,0.00047556337,0.007975478],"genre_scores_gemma":[0.9883193,0.0019868382,0.004089577,0.000053085372,0.000013859614,0.000032627006,0.0007064589,0.000022806707,0.0047753765],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988985,0.000011246367,0.0000057759753,0.000029050201,0.000038010643,0.000026126625],"domain_scores_gemma":[0.99995816,0.0000063284992,0.000008915698,0.0000031649752,0.000007550148,0.000015840082],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010881978,0.00026356228,0.00014551541,0.0002282972,0.00013333136,0.00018833287,0.00025388369,0.00018610434,0.0011352933],"category_scores_gemma":[0.000099698365,0.00011113696,0.00012278647,0.00012258922,0.00022440609,0.00021655335,0.00021373486,0.0003273308,0.0005554625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000069058035,0.000008020117,0.00015320376,0.000038067956,0.0000012737208,0.000050942155,0.000013250483,0.000034705623,0.9965663,0.00033433558,0.000058864443,0.0026718893],"study_design_scores_gemma":[0.000010414398,0.00004873681,0.004204017,0.0000060882244,0.000004190737,0.00009700656,0.00001713107,0.00076170266,0.9906213,0.00015396702,0.0040722955,0.0000032076937],"about_ca_topic_score_codex":0.0012458942,"about_ca_topic_score_gemma":0.0018358651,"teacher_disagreement_score":0.0012458942,"about_ca_system_score_codex":0.00055654964,"about_ca_system_score_gemma":0.0002208524,"threshold_uncertainty_score":0.004038036},"labels":[],"label_agreement":null},{"id":"W2119750849","doi":"10.1093/annonc/mdv033","title":"A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas—NCIC-CTG IND 200","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; University of Toronto; Mount Sinai Hospital; University of Calgary; McGill University; Princess Margaret Cancer Centre; BC Cancer Agency; Juravinski Cancer Centre; Alberta Cancer Foundation; University of Alberta","funders":"National Cancer Institute; Canadian Cancer Society Research Institute","keywords":"Medicine; Chromosomal translocation; Cancer research; Population; Histone deacetylase 2; Internal medicine; Oncology; Fusion gene; PTEN; PI3K/AKT/mTOR pathway; Histone deacetylase; Histone; Apoptosis; Biology; Genetics; Gene","score_opus":0.07395527588728779,"score_gpt":0.40082570793998334,"score_spread":0.32687043205269556,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119750849","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9899815,0.0029241864,0.00079112523,0.0007910464,0.00019092365,0.0012865333,0.0012014207,0.00015332195,0.0026799166],"genre_scores_gemma":[0.98695755,0.0028647198,0.0017633808,0.0009036947,0.00012559662,0.0010074195,0.0032553463,0.000046849298,0.0030755037],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99972755,0.00010204256,0.000013593471,0.000052867243,0.000025127712,0.00007879315],"domain_scores_gemma":[0.9996196,0.000060406623,0.000040555165,0.000033913173,0.000021270727,0.0002242994],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009813663,0.0013851942,0.002036298,0.00049456337,0.00047559923,0.00087603176,0.0009889586,0.0010597793,0.0031720193],"category_scores_gemma":[0.00052024046,0.00053938787,0.0014697347,0.0004995605,0.00085225684,0.0007088404,0.0003067685,0.0033357497,0.0009080263],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.5338857,0.07804681,0.013609368,0.0009719915,0.0032620498,0.00069161295,0.0005718677,0.0067113354,0.115285605,0.000808771,0.01033248,0.2358223],"study_design_scores_gemma":[0.40722626,0.55084735,0.022801869,0.00005195777,0.0010770757,0.0007745164,0.00017988529,0.0030368818,0.007095236,0.0003887142,0.0064561255,0.00006410479],"about_ca_topic_score_codex":0.003193143,"about_ca_topic_score_gemma":0.009800187,"teacher_disagreement_score":0.003193143,"about_ca_system_score_codex":0.0009860148,"about_ca_system_score_gemma":0.0014728352,"threshold_uncertainty_score":0.010611415},"labels":[],"label_agreement":null},{"id":"W2119777544","doi":"10.1517/17460441.3.9.1041","title":"Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases","year":2008,"lang":"en","type":"article","venue":"Expert Opinion on Drug Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre; Pyrogenesis (Canada)","funders":"","keywords":"Vorinostat; Histone deacetylase; Histone; Medicine; Epigenetics; Bioinformatics; Cancer; Inflammation; Cancer research; Pharmacology; Computational biology; Biology; Immunology; Genetics; Internal medicine","score_opus":0.02310778815169696,"score_gpt":0.353628319070424,"score_spread":0.3305205309187271,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119777544","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.014522086,0.9542761,0.008382914,0.006937948,0.0017713672,0.0001280257,0.00020623252,0.00015643191,0.013619041],"genre_scores_gemma":[0.08166919,0.8930197,0.009789903,0.0030351111,0.001317631,0.0001225519,0.0003975766,0.000027182647,0.0106212],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998492,0.000031399355,0.000013443479,0.000023440163,0.00006042465,0.000022023965],"domain_scores_gemma":[0.9999194,0.000015797319,0.000021118816,0.0000048600336,0.000024997957,0.000013738987],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00049239094,0.00063410675,0.00078525016,0.00057293853,0.0001952185,0.0005060095,0.0005604954,0.0008204112,0.0042355796],"category_scores_gemma":[0.00023122763,0.0001394272,0.0004113584,0.00040796146,0.00029802579,0.00048724603,0.00021182961,0.00094242964,0.0019617511],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00081911235,0.00044080222,0.00065934577,0.0049600797,0.00019076155,0.00095264864,0.00006370386,0.00064347585,0.25848162,0.007325519,0.03270968,0.6927532],"study_design_scores_gemma":[0.0010505342,0.003071741,0.004758277,0.0009781295,0.00060759485,0.007306668,0.00012884536,0.0013007723,0.12368146,0.006882092,0.8501571,0.00007672211],"about_ca_topic_score_codex":0.00041442315,"about_ca_topic_score_gemma":0.0014537964,"teacher_disagreement_score":0.0042355796,"about_ca_system_score_codex":0.00055170275,"about_ca_system_score_gemma":0.00057956117,"threshold_uncertainty_score":0.014169395},"labels":[],"label_agreement":null},{"id":"W2120122600","doi":"10.1158/1538-7445.am2011-lb-411","title":"Abstract LB-411: A phase II study of combination epigenetic therapy in advanced non-small cell lung cancer","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Lung cancer; Oncology; Internal medicine; Cancer; Azacitidine; Regimen; Phases of clinical research; Progressive disease; Epigenetic therapy; Chemotherapy; DNA methylation; Biology; Gene","score_opus":0.061126527416377995,"score_gpt":0.4104860179981775,"score_spread":0.34935949058179955,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2120122600","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9944825,0.00078569,0.0005051063,0.00025470913,0.000057944937,0.0015095061,0.00054454844,0.00011339941,0.0017466072],"genre_scores_gemma":[0.98740935,0.0013929663,0.0019290054,0.00050466566,0.00014065321,0.0021875724,0.0027077687,0.000038641618,0.0036894307],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99954504,0.00022688921,0.000030441051,0.00006476136,0.000055674074,0.000077199664],"domain_scores_gemma":[0.99958783,0.00006296016,0.000056662342,0.000049004397,0.000032129774,0.00021130579],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013782037,0.0013163346,0.0016846395,0.0005677057,0.0006105519,0.00079090305,0.0011288454,0.0013351052,0.0042387606],"category_scores_gemma":[0.0004450071,0.0006076374,0.000982283,0.00055239076,0.0009159641,0.00058854115,0.0004518668,0.0031389869,0.0012050442],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.33530608,0.21382621,0.019370113,0.0015231303,0.0013695614,0.0007622819,0.0005590193,0.0045902985,0.23987256,0.00055020605,0.005801412,0.17646913],"study_design_scores_gemma":[0.16743141,0.7998024,0.015846215,0.0000486967,0.00031568902,0.0005285934,0.00007970702,0.0014713709,0.01123465,0.00011653579,0.003088258,0.000036461504],"about_ca_topic_score_codex":0.0011458795,"about_ca_topic_score_gemma":0.0024661478,"teacher_disagreement_score":0.0042387606,"about_ca_system_score_codex":0.000669008,"about_ca_system_score_gemma":0.0017490234,"threshold_uncertainty_score":0.014180064},"labels":[],"label_agreement":null},{"id":"W2120706978","doi":"10.1158/1078-0432.ccr-08-2999","title":"A Phase I, Pharmacokinetic and Pharmacodynamic Study on Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Kimberly-Clark","keywords":"Vorinostat; Pharmacokinetics; Medicine; Oxaliplatin; FOLFOX; Pharmacology; Cmax; Fluorouracil; Leukopenia; Internal medicine; Gastroenterology; Colorectal cancer; Oncology; Chemotherapy; Cancer; Chemistry; Histone deacetylase","score_opus":0.05236298826956668,"score_gpt":0.4732157032925411,"score_spread":0.4208527150229744,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2120706978","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99656624,0.0014341897,0.0003841172,0.00024014458,0.00006125242,0.0006037349,0.00019899763,0.000040393712,0.00047089823],"genre_scores_gemma":[0.99517375,0.000991734,0.0011097152,0.0004132112,0.00015421165,0.000672444,0.0006988648,0.000016557698,0.0007695395],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99937063,0.00033140383,0.000031765725,0.00009007729,0.00008043327,0.000095650954],"domain_scores_gemma":[0.99912447,0.00019644048,0.00022026175,0.00006244697,0.000046998157,0.00034938473],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013011241,0.0013095022,0.0020692556,0.0004505105,0.0005225891,0.0007776113,0.00070864183,0.0008923273,0.0016755508],"category_scores_gemma":[0.0011224989,0.00067759445,0.0010289012,0.00048633537,0.001183769,0.00079024886,0.00022847137,0.0025083108,0.00043881795],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.561492,0.10161388,0.01564147,0.0012774671,0.0018804036,0.00087057386,0.000619505,0.004777244,0.18041348,0.0003172759,0.0031096423,0.12798698],"study_design_scores_gemma":[0.24493901,0.72577304,0.016416576,0.000028553437,0.00045927163,0.0005142205,0.00006467432,0.0015530952,0.007958914,0.00008896478,0.002166046,0.00003769273],"about_ca_topic_score_codex":0.0006629188,"about_ca_topic_score_gemma":0.001773779,"teacher_disagreement_score":0.0020692556,"about_ca_system_score_codex":0.0008684112,"about_ca_system_score_gemma":0.0016007532,"threshold_uncertainty_score":0.006881058},"labels":[],"label_agreement":null},{"id":"W2121302081","doi":"10.1158/1078-0432.ccr-07-1934","title":"Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Romidepsin; Bortezomib; Cancer research; Histone deacetylase; Vorinostat; Apoptosis; Chronic lymphocytic leukemia; Transfection; Proteasome inhibitor; Chemistry; Biology; Molecular biology; Cell culture; Leukemia; Histone; Immunology; Biochemistry; Multiple myeloma","score_opus":0.16226796167219082,"score_gpt":0.4939002752768028,"score_spread":0.331632313604612,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2121302081","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9880288,0.008387594,0.0008119946,0.00017748018,0.000049545877,0.00003185509,0.00033732894,0.00004621929,0.0021291715],"genre_scores_gemma":[0.99536586,0.0018567472,0.0006050051,0.00010627997,0.000019287065,0.000035368812,0.00059547083,0.000005220752,0.0014107585],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999635,0.000088999535,0.000023122453,0.000058084348,0.00012459583,0.00007017785],"domain_scores_gemma":[0.99991703,0.000016814081,0.000023850544,0.00000745316,0.00001481243,0.000020039573],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014656161,0.00029341393,0.00048719466,0.00016438065,0.00026222406,0.00046264942,0.00016502845,0.0002628927,0.0015293509],"category_scores_gemma":[0.0001279307,0.00015967256,0.00033861544,0.00020960851,0.00015773498,0.00022895986,0.00021074538,0.00031467396,0.00067220035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00057511893,0.00008751008,0.0017398878,0.00013579015,0.000049070823,0.000140857,0.00004026667,0.00016039453,0.9930559,0.000057809084,0.00020071892,0.0037566903],"study_design_scores_gemma":[0.00017385269,0.001975432,0.048044324,0.000024207331,0.0001087179,0.0014393474,0.00020921876,0.0017511903,0.93251663,0.00008120392,0.013659084,0.000016800197],"about_ca_topic_score_codex":0.0011901582,"about_ca_topic_score_gemma":0.0020302797,"teacher_disagreement_score":0.0015293509,"about_ca_system_score_codex":0.0006257166,"about_ca_system_score_gemma":0.00029070023,"threshold_uncertainty_score":0.0051162243},"labels":[],"label_agreement":null},{"id":"W2123105005","doi":"10.1074/jbc.m513503200","title":"Role of Histone Deacetylase in the Expression of CTP:Phosphocholine Cytidylyltransferase α","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"Trichostatin A; Histone deacetylase; Chromatin immunoprecipitation; Histone deacetylase 5; Acetylation; Histone deacetylase 2; HDAC1; HDAC11; Psychological repression; Histone; Phosphocholine; Molecular biology; Chromatin remodeling; HDAC4; HDAC10; E2F; Chromatin; Biology; SAP30; Histone H2A; Gene expression; Biochemistry; Gene; Promoter","score_opus":0.010343950480844294,"score_gpt":0.2871712881016216,"score_spread":0.2768273376207773,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2123105005","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98886126,0.005601214,0.0033037236,0.000114666036,0.000040045987,0.000036815265,0.0006188928,0.000052531337,0.0013708228],"genre_scores_gemma":[0.992664,0.0022005187,0.0017108768,0.00005789091,0.000013057773,0.000028325363,0.0008590334,0.00001542378,0.0024509246],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986017,0.0000114018,0.000014391716,0.000042402153,0.00003442425,0.000037136393],"domain_scores_gemma":[0.9998692,0.000016116504,0.00003310663,0.000016805665,0.00002354789,0.000041039748],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012224463,0.00039621565,0.00023747582,0.00022507015,0.00018382611,0.00031882798,0.00021427436,0.00025182634,0.0009130677],"category_scores_gemma":[0.00010853604,0.00016290019,0.00037647347,0.00020514279,0.00026352008,0.00017311577,0.00014666255,0.0004355114,0.00037739766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006299781,0.00000559768,0.0004673341,0.000017102997,0.0000026885818,0.00004762104,0.000008523055,0.000012112236,0.9988186,0.000030297097,0.000008449705,0.000518724],"study_design_scores_gemma":[0.000019636975,0.00015984835,0.03097166,0.000008871419,0.000020675961,0.0002909316,0.00004039599,0.0004925291,0.96664155,0.000047161895,0.0013015238,0.000005386481],"about_ca_topic_score_codex":0.003288014,"about_ca_topic_score_gemma":0.0030769652,"teacher_disagreement_score":0.003288014,"about_ca_system_score_codex":0.0005344394,"about_ca_system_score_gemma":0.0003052948,"threshold_uncertainty_score":0.0065377355},"labels":[],"label_agreement":null},{"id":"W2124016629","doi":"10.1371/journal.pone.0055529","title":"HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Invadopodia; HDAC6; Cell biology; Cancer research; Histone deacetylase; Chemistry; Cancer cell; Biology; Cancer; Histone; Biochemistry","score_opus":0.0572360266295976,"score_gpt":0.25683786166689043,"score_spread":0.19960183503729284,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2124016629","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9827262,0.006626983,0.005821235,0.000317187,0.000111039415,0.000033436463,0.0009790605,0.00015391718,0.0032309243],"genre_scores_gemma":[0.9921584,0.0018527606,0.001940969,0.000052522646,0.000020480082,0.000017463832,0.0010740989,0.000024435456,0.0028589298],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998789,0.000013802201,0.000013019024,0.00002467784,0.00003368027,0.000035876128],"domain_scores_gemma":[0.999864,0.000011084357,0.000043104777,0.000014197483,0.000017829454,0.000049724942],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112502,0.00024240195,0.00029686763,0.0001401002,0.0001845254,0.0002682124,0.0001895507,0.00019949426,0.0017092713],"category_scores_gemma":[0.00013669938,0.00018947138,0.0004151183,0.00010342096,0.0001723614,0.0001808247,0.00018903884,0.0004542958,0.0005757731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020171939,0.000021250667,0.00055069465,0.000039606664,0.0000068627405,0.000069186404,0.000008297022,0.00003814916,0.9975727,0.0001320804,0.00008192186,0.0012775244],"study_design_scores_gemma":[0.000040208717,0.00020282359,0.040700667,0.00000985078,0.00002549249,0.00063011085,0.000044140303,0.0013355818,0.94996727,0.00013163226,0.0069043986,0.000007898343],"about_ca_topic_score_codex":0.00084155024,"about_ca_topic_score_gemma":0.0016886009,"teacher_disagreement_score":0.0017092713,"about_ca_system_score_codex":0.00030016387,"about_ca_system_score_gemma":0.00023191937,"threshold_uncertainty_score":0.005718112},"labels":[],"label_agreement":null},{"id":"W2124328035","doi":"10.1158/1535-7163.mct-05-0157","title":"Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells","year":2005,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"XIAP; Histone deacetylase inhibitor; Apoptosis; Biology; Inhibitor of apoptosis; Free radical scavenger; Histone deacetylase; Cyclin-dependent kinase; Molecular biology; Chemistry; Cancer research; Programmed cell death; Biochemistry; Cell cycle; Caspase; Histone; Oxidative stress","score_opus":0.01260473809142781,"score_gpt":0.29945841185625754,"score_spread":0.28685367376482973,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2124328035","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99583983,0.0016197683,0.0009032378,0.000042878837,0.000014427876,0.000025360232,0.0002400785,0.00005985015,0.0012546128],"genre_scores_gemma":[0.99693537,0.0008279924,0.0005973855,0.000020058742,0.0000073072365,0.000031770564,0.0004936058,0.000010839078,0.0010757868],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991953,0.000020078802,0.000009366281,0.000012448203,0.00001838918,0.000020142725],"domain_scores_gemma":[0.9999404,0.000011001508,0.00001558819,0.000011930789,0.000009572891,0.000011570777],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011776919,0.00035686637,0.00027010165,0.00015285081,0.00012204232,0.0002336227,0.00018696465,0.00016548512,0.00085476536],"category_scores_gemma":[0.0001047088,0.00010627826,0.00021206887,0.00017724773,0.00012507223,0.00014330687,0.00015490732,0.00032883245,0.00031787768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042877867,0.00008348842,0.00032505093,0.00003393222,0.000015459706,0.00006066525,0.00002875594,0.00020524219,0.9962998,0.00011953577,0.000064755804,0.0023345863],"study_design_scores_gemma":[0.000048881026,0.00076415186,0.0031675133,0.0000029356456,0.000019271842,0.000118475946,0.000016528282,0.0006527198,0.9933442,0.00001887492,0.001843386,0.0000029758357],"about_ca_topic_score_codex":0.0013547235,"about_ca_topic_score_gemma":0.0017796372,"teacher_disagreement_score":0.0013547235,"about_ca_system_score_codex":0.00035007964,"about_ca_system_score_gemma":0.00021983344,"threshold_uncertainty_score":0.0028594732},"labels":[],"label_agreement":null},{"id":"W2124373649","doi":"10.1186/1475-2867-8-16","title":"Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on human Ewing's sarcoma cells","year":2008,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trichostatin A; Histone deacetylase; Cancer research; Epigenetics; Histone deacetylase inhibitor; Clonogenic assay; Vorinostat; Azacitidine; Phenylbutyrate; Acetylation; DNA methylation; Romidepsin; Histone; Medicine; Biology; Cell culture; Gene expression; Internal medicine; Genetics; Gene","score_opus":0.08771794342872184,"score_gpt":0.4003996044951786,"score_spread":0.31268166106645673,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2124373649","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98823535,0.0051825913,0.0016606211,0.00012311329,0.00009014561,0.00040731597,0.0010174386,0.000114705515,0.0031687524],"genre_scores_gemma":[0.9896632,0.0040164446,0.0021506157,0.000048614136,0.00003675696,0.0002167415,0.0013961804,0.000017010734,0.0024543582],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983287,0.00005029412,0.000014553244,0.00002393165,0.000039135382,0.00003921567],"domain_scores_gemma":[0.9998282,0.000047053065,0.000028498818,0.000021355929,0.00002789746,0.000047008078],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044032934,0.0007203594,0.000559728,0.0004142326,0.0001930743,0.00023613445,0.0005267363,0.0003447416,0.0024159246],"category_scores_gemma":[0.00015568621,0.0002441425,0.00046859353,0.00034934716,0.000280707,0.00022421019,0.0001440589,0.00072682375,0.0004104817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028474752,0.0029031755,0.0005204787,0.00027319408,0.000071154056,0.000079871905,0.000053525666,0.0014642827,0.9821922,0.00017626442,0.00028914763,0.009129269],"study_design_scores_gemma":[0.000732234,0.06158246,0.004566013,0.000018294217,0.00019385845,0.00019176793,0.00003696767,0.0013090326,0.9276194,0.000043552078,0.0036964728,0.000009977897],"about_ca_topic_score_codex":0.0020935216,"about_ca_topic_score_gemma":0.0031363443,"teacher_disagreement_score":0.0024159246,"about_ca_system_score_codex":0.0004163125,"about_ca_system_score_gemma":0.0005789663,"threshold_uncertainty_score":0.008082092},"labels":[],"label_agreement":null},{"id":"W2124823115","doi":"10.1155/2012/491685","title":"Acquiring Metastatic Competence by Oral Squamous Cell Carcinoma Cells Is Associated with Differential Expression of<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"><mml:mi mathvariant=\"bold\">α</mml:mi></mml:math>-Tubulin Isoforms","year":2012,"lang":"en","type":"article","venue":"Journal of Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institutes of Health; York University","keywords":"Medicine; Basal cell; Competence (human resources); Oncology; Internal medicine; Psychology","score_opus":0.01612649883071072,"score_gpt":0.26252108108942646,"score_spread":0.24639458225871574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2124823115","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9983254,0.00022096404,0.00022590376,0.000019600831,0.0000029532832,0.0000070727715,0.00023065148,0.000012862312,0.000954562],"genre_scores_gemma":[0.99648833,0.00037816472,0.0004535422,0.000018394647,0.0000024760482,0.000016738666,0.00075807335,0.0000056646295,0.0018785422],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999273,0.0000040859613,0.000005381394,0.00001153836,0.000026814065,0.000024940906],"domain_scores_gemma":[0.99995506,0.000004952551,0.000007865831,0.0000046817063,0.000010820584,0.000016642662],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005234833,0.00016133598,0.00014880158,0.00019119034,0.00016934438,0.000275413,0.00005479994,0.00014181077,0.0015040297],"category_scores_gemma":[0.00008107008,0.00013199062,0.00018510886,0.00018117989,0.00009554129,0.00009371918,0.00015425067,0.0002522163,0.00042868467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000034409608,0.000013672793,0.0012607632,0.000015476307,0.0000025961265,0.000097958895,0.000022956458,0.000014645673,0.99764556,0.000032777436,0.00004178033,0.00081741833],"study_design_scores_gemma":[0.000021087088,0.0006046319,0.24148281,0.000013388079,0.00004049113,0.003046782,0.00044970712,0.0011274427,0.74822146,0.000117775846,0.0048576705,0.000016721875],"about_ca_topic_score_codex":0.0019253579,"about_ca_topic_score_gemma":0.0029989989,"teacher_disagreement_score":0.0019253579,"about_ca_system_score_codex":0.00016335299,"about_ca_system_score_gemma":0.00017224441,"threshold_uncertainty_score":0.0050314665},"labels":[],"label_agreement":null},{"id":"W2124936150","doi":"10.1161/01.res.0000251744.06138.50","title":"Transcriptional Silencing of the Death Gene BNIP3 by Cooperative Action of NF-κB and Histone Deacetylase 1 in Ventricular Myocytes","year":2006,"lang":"en","type":"article","venue":"Circulation Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; CancerCare Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Transactivation; Trichostatin A; HDAC1; Transcription factor; Histone deacetylase; Biology; Cell biology; Psychological repression; Gene silencing; NF-κB; Transcription (linguistics); Chromatin immunoprecipitation; Regulation of gene expression; Promoter; Myocyte; Gene expression; Histone; Gene; Signal transduction; Genetics","score_opus":0.03967609310266987,"score_gpt":0.34869980964786906,"score_spread":0.3090237165451992,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2124936150","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99054855,0.0021533477,0.006027084,0.000084202424,0.0000283608,0.000017050179,0.00021742875,0.00005880217,0.0008651515],"genre_scores_gemma":[0.9954045,0.0008032839,0.0021977783,0.00005341599,0.00001588089,0.00002992556,0.0003331455,0.000018093753,0.0011440492],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998735,0.000015803134,0.000014474067,0.000032311644,0.000028172346,0.000035848097],"domain_scores_gemma":[0.99990106,0.000015370739,0.000036889796,0.000014406381,0.000009578523,0.000022832484],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882126,0.0003492188,0.0002633327,0.000104229235,0.00012411998,0.00022071134,0.00020143087,0.00012851821,0.0005275262],"category_scores_gemma":[0.000100757126,0.00016814952,0.00028962715,0.00009901535,0.00028077952,0.00014559008,0.0003000331,0.00044922487,0.0002057638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000038643404,0.0000033865297,0.00009211378,0.000011578226,0.0000026733992,0.000026797488,0.0000063462926,0.000014521352,0.99946064,0.000025444917,0.000006278838,0.0003117144],"study_design_scores_gemma":[0.000025759819,0.00024653896,0.008985535,0.00000725273,0.000023765506,0.00036477228,0.000045791036,0.00088234706,0.9881561,0.00010334632,0.0011544722,0.0000043157456],"about_ca_topic_score_codex":0.00043015712,"about_ca_topic_score_gemma":0.0006391741,"teacher_disagreement_score":0.0005275262,"about_ca_system_score_codex":0.0002717947,"about_ca_system_score_gemma":0.00020824574,"threshold_uncertainty_score":0.0019720197},"labels":[],"label_agreement":null},{"id":"W2125850880","doi":"10.1016/j.bmc.2015.11.005","title":"Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Chemistry; Histone deacetylase inhibitor; Antiestrogen; Histone deacetylase; HDAC6; Stereochemistry; Biochemistry; Pharmacology; Histone; Genetics; Tamoxifen; Gene","score_opus":0.03669522753424448,"score_gpt":0.3114211009657903,"score_spread":0.2747258734315458,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2125850880","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95105267,0.0068772873,0.027469935,0.00041874434,0.0001396969,0.00034270488,0.0008537811,0.0003121249,0.0125330845],"genre_scores_gemma":[0.97569317,0.0026817794,0.013045792,0.0001490394,0.00001847334,0.00015337163,0.00054658577,0.000022597647,0.007689097],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999263,0.000010866871,0.000004933637,0.00001625005,0.000019206913,0.000022526108],"domain_scores_gemma":[0.9999509,0.000009014055,0.000013330272,0.000004522064,0.0000111102445,0.000011159186],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019201207,0.00025405537,0.00018835117,0.00023677404,0.0001724505,0.00032676116,0.00043150914,0.00030527762,0.0020535404],"category_scores_gemma":[0.00014731767,0.00016698506,0.00022761428,0.00017944514,0.00010748324,0.00027574957,0.00018826518,0.00034296076,0.00044704665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003236214,0.00023794941,0.00030410668,0.00023788158,0.000059950267,0.00022484084,0.00007787146,0.0040879096,0.9677999,0.0036723202,0.0005331861,0.022440432],"study_design_scores_gemma":[0.000082959064,0.0017642212,0.0006712091,0.000011386313,0.00007197463,0.00019240717,0.00003907774,0.0020945782,0.97466516,0.00024677505,0.02013824,0.000022086906],"about_ca_topic_score_codex":0.00038131553,"about_ca_topic_score_gemma":0.0008629396,"teacher_disagreement_score":0.0020535404,"about_ca_system_score_codex":0.00038820744,"about_ca_system_score_gemma":0.0001929867,"threshold_uncertainty_score":0.0068697333},"labels":[],"label_agreement":null},{"id":"W2126632735","doi":"10.1158/0008-5472.can-13-3531","title":"Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institutes of Health","keywords":"Gene isoform; Chemistry; Pharmacology; Internal medicine; Medicine; Biochemistry; Gene","score_opus":0.02131215016680877,"score_gpt":0.35533211698472733,"score_spread":0.33401996681791857,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2126632735","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9942813,0.0013324018,0.0016090834,0.00008161926,0.00005184816,0.000047799258,0.00017936736,0.00016390313,0.002252743],"genre_scores_gemma":[0.99657357,0.00088897935,0.0005196757,0.000028778713,0.000010171264,0.000033892993,0.00022486845,0.000019547486,0.001700572],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993896,0.000011882014,0.0000054483626,0.000009333935,0.000013840069,0.000020553513],"domain_scores_gemma":[0.99995613,0.000008704798,0.000008340746,0.0000105018935,0.0000053054277,0.000011011264],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015419288,0.00041627022,0.000389636,0.00022711871,0.00010924221,0.00016153857,0.00013164307,0.00015206028,0.0010535101],"category_scores_gemma":[0.00006454448,0.00010592718,0.0001925935,0.00014022824,0.00017059034,0.000113844464,0.00011689236,0.0004822789,0.00019317983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004936433,0.00024171908,0.0002300057,0.00005055688,0.000016690214,0.000041425927,0.000017272092,0.00017173534,0.99345714,0.000121873054,0.000112096364,0.0050458065],"study_design_scores_gemma":[0.00019629358,0.003455639,0.002754021,0.0000057466877,0.000053609307,0.00013830842,0.000024226576,0.0014193238,0.98976934,0.000043734242,0.0021355753,0.0000042121887],"about_ca_topic_score_codex":0.0007306402,"about_ca_topic_score_gemma":0.0011931122,"teacher_disagreement_score":0.0010535101,"about_ca_system_score_codex":0.00018356531,"about_ca_system_score_gemma":0.00020565493,"threshold_uncertainty_score":0.003524363},"labels":[],"label_agreement":null},{"id":"W2127275456","doi":"10.1517/13543784.17.8.1247","title":"Promising antitumor activity with MGCD0103, a novel isotype-selective histone deacetylase inhibitor","year":2008,"lang":"en","type":"review","venue":"Expert Opinion on Investigational Drugs","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Fondation de France","keywords":"Pharmacodynamics; Histone; Cancer research; Histone deacetylase; Pharmacokinetics; Pharmacology; Histone deacetylase inhibitor; Medicine; Cancer; Gene; Chemistry; Biology; Internal medicine; Biochemistry","score_opus":0.04875667779882451,"score_gpt":0.3654440281644459,"score_spread":0.31668735036562135,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2127275456","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.006593903,0.9878177,0.00070147327,0.0003900894,0.00016701141,0.000022352062,0.00006125479,0.000036021163,0.004210152],"genre_scores_gemma":[0.030143952,0.96272486,0.0016068374,0.0006250632,0.00019480447,0.000030838033,0.00023493446,0.000006158591,0.0044325516],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999244,0.00001057196,0.0000074568266,0.0000155341,0.00003093334,0.000010969536],"domain_scores_gemma":[0.99996746,0.0000088738925,0.000007644289,0.0000012324041,0.000009268735,0.0000054755105],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027828608,0.0004542949,0.0006266891,0.000450512,0.000108562956,0.0003725551,0.00044150773,0.0004461833,0.0022007423],"category_scores_gemma":[0.00014112928,0.00009059879,0.00031319514,0.00058515416,0.00012845302,0.00032746815,0.00013793712,0.0004611698,0.0010234782],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036193954,0.00012244999,0.00044666472,0.005171471,0.00007815513,0.00062874047,0.000034177487,0.0002665753,0.034690302,0.0008333264,0.007799237,0.9495669],"study_design_scores_gemma":[0.00052833685,0.0026877872,0.00743356,0.0013159203,0.0005735061,0.012806296,0.000103767845,0.00052791927,0.042870775,0.0011975789,0.92990667,0.000047822494],"about_ca_topic_score_codex":0.00063777086,"about_ca_topic_score_gemma":0.0014160365,"teacher_disagreement_score":0.0022007423,"about_ca_system_score_codex":0.00041553614,"about_ca_system_score_gemma":0.00044215354,"threshold_uncertainty_score":0.0073622465},"labels":[],"label_agreement":null},{"id":"W2127672786","doi":"10.1016/j.ejca.2005.09.005","title":"Transcription factors in cancer","year":2005,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Transcription factor; Biology; Cell biology; Cancer cell; Cell growth; Gene; Apoptosis; Cancer research; Cancer; Transcriptional regulation; Genetics","score_opus":0.02277975977043206,"score_gpt":0.31496208230951034,"score_spread":0.2921823225390783,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2127672786","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.013904412,0.9196964,0.004547327,0.021359013,0.0043362863,0.000026767724,0.00048860145,0.00020479916,0.035436414],"genre_scores_gemma":[0.15659137,0.7413209,0.003759555,0.0047178683,0.00360771,0.00006581946,0.0012244626,0.00006249278,0.08864987],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99984217,0.00002069727,0.000012530874,0.000032543558,0.00005558445,0.000036525416],"domain_scores_gemma":[0.99986553,0.000022275653,0.00001974534,0.000015592732,0.000030285326,0.0000465189],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00047126715,0.0004319563,0.0004160901,0.0010020946,0.0005085502,0.0009767634,0.0004944835,0.0006924813,0.005901978],"category_scores_gemma":[0.0002935502,0.00023975338,0.00025751564,0.0010647299,0.0008878586,0.00086949463,0.00060377124,0.0013517161,0.002499657],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00082473265,0.00014886892,0.002743886,0.0022924559,0.00012571337,0.0012584213,0.0006005571,0.0010686257,0.13386782,0.15855259,0.12275267,0.5757637],"study_design_scores_gemma":[0.000021670914,0.00006325724,0.0019446732,0.0001281391,0.000030915497,0.0009274053,0.00014020146,0.0001554638,0.011789214,0.009921002,0.9748683,0.000009801103],"about_ca_topic_score_codex":0.0024027799,"about_ca_topic_score_gemma":0.0034370518,"teacher_disagreement_score":0.005901978,"about_ca_system_score_codex":0.0015670798,"about_ca_system_score_gemma":0.0008335678,"threshold_uncertainty_score":0.019744158},"labels":[],"label_agreement":null},{"id":"W2129522972","doi":"10.1158/1078-0432.ccr-07-0318","title":"Tolerability, Pharmacodynamics, and Pharmacokinetics Studies of Depsipeptide (Romidepsin) in Patients with Acute Myelogenous Leukemia or Advanced Myelodysplastic Syndromes","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Leukemia and Lymphoma Society","keywords":"Medicine; Neutropenia; Tolerability; Depsipeptide; Pharmacology; Pharmacodynamics; Internal medicine; Leukemia; Myeloid leukemia; Oncology; Pharmacokinetics; Chemotherapy; Adverse effect; Biology","score_opus":0.12817282416867606,"score_gpt":0.4773455310330927,"score_spread":0.3491727068644166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2129522972","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9972222,0.001715695,0.00043415985,0.00007622995,0.000007660896,0.00004832973,0.00009786794,0.000020893043,0.00037714007],"genre_scores_gemma":[0.9985153,0.0005536688,0.00037562184,0.00011099295,0.000026614262,0.000038301005,0.00020040272,0.000004992756,0.00017398526],"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99975735,0.00014119127,0.000015966927,0.00003192001,0.000034185952,0.000019373821],"domain_scores_gemma":[0.9996294,0.000110324116,0.00013760681,0.000018184714,0.000024807201,0.000079684316],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004846058,0.00045089202,0.00061238674,0.00010170798,0.00012081531,0.00021040124,0.00015857542,0.0002221796,0.00057959574],"category_scores_gemma":[0.00074744655,0.00012255895,0.00032200766,0.0001418991,0.00022602259,0.00016321737,0.000086903274,0.0005493315,0.00017180188],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.15228848,0.0066610146,0.16725813,0.00093741115,0.0014472093,0.0026849457,0.00067370036,0.007596958,0.3943139,0.00026507577,0.0023992346,0.26347387],"study_design_scores_gemma":[0.014914698,0.52740055,0.38345906,0.000066678695,0.0010215518,0.0072287773,0.00019599547,0.0057523455,0.052246936,0.00020830167,0.007463822,0.000041225667],"about_ca_topic_score_codex":0.00022848707,"about_ca_topic_score_gemma":0.00039250214,"teacher_disagreement_score":0.00061238674,"about_ca_system_score_codex":0.00024571994,"about_ca_system_score_gemma":0.0001614842,"threshold_uncertainty_score":0.002562821},"labels":[],"label_agreement":null},{"id":"W2129768414","doi":"10.1093/carcin/bgl167","title":"Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes","year":2006,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":256,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Epigenetics; Chromatin immunoprecipitation; Reprogramming; Epigenome; Biology; Histone deacetylase inhibitor; Histone deacetylase; Histone; Trichostatin A; Chromatin; Methylated DNA immunoprecipitation; Epigenomics; DNA demethylation; Molecular biology; Acetylation; Cancer research; Gene expression; Gene; Genetics; Promoter","score_opus":0.018594286283674433,"score_gpt":0.25553785336431734,"score_spread":0.2369435670806429,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2129768414","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9891789,0.0039692665,0.002850021,0.00014634639,0.00008943714,0.000061388346,0.0010234495,0.0002506495,0.0024306958],"genre_scores_gemma":[0.99318635,0.0019692911,0.0014241157,0.00011152261,0.00002766007,0.00005193083,0.00092335255,0.000021437696,0.0022842519],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986017,0.00002736501,0.00001144791,0.000040900944,0.00003396432,0.000026135245],"domain_scores_gemma":[0.9999399,0.000011665304,0.000023270666,0.000009403831,0.0000050631747,0.000010707524],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008149189,0.00045269824,0.00031189003,0.00025386724,0.00011704551,0.00017885496,0.00013388607,0.0002149441,0.0010937362],"category_scores_gemma":[0.00008701132,0.0001358388,0.00029292257,0.00014159594,0.00020761807,0.00007973016,0.0001981617,0.00035717693,0.00018688178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001783766,0.000022068129,0.00023254247,0.00003113729,0.00001221012,0.00008411503,0.0000097358425,0.00005132604,0.99698085,0.00007152502,0.000053389263,0.0022726757],"study_design_scores_gemma":[0.000046813064,0.0011777602,0.010349942,0.000007803934,0.000029872117,0.0006189272,0.000021813656,0.00046540904,0.98157597,0.00012556915,0.0055748676,0.0000052499763],"about_ca_topic_score_codex":0.00039768123,"about_ca_topic_score_gemma":0.00074235647,"teacher_disagreement_score":0.0010937362,"about_ca_system_score_codex":0.00024003585,"about_ca_system_score_gemma":0.00011781591,"threshold_uncertainty_score":0.0036589503},"labels":[],"label_agreement":null},{"id":"W2129890171","doi":"10.1158/1078-0432.ccr-03-0561","title":"Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors","year":2004,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":381,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Bortezomib; Sodium butyrate; Apoptosis; Histone deacetylase inhibitor; Histone deacetylase; Proteasome inhibitor; Chemistry; Pharmacology; Cancer research; Biology; Multiple myeloma; Biochemistry; Histone; Immunology","score_opus":0.05259905812903075,"score_gpt":0.42632650504431585,"score_spread":0.3737274469152851,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2129890171","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9924205,0.005333503,0.0010347196,0.00008110186,0.00004168075,0.000045099063,0.00017960781,0.000033916596,0.00082992093],"genre_scores_gemma":[0.995769,0.0020305393,0.0009694097,0.00006522668,0.000023987799,0.00004705734,0.00032875934,0.000004555326,0.00076147733],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997508,0.00004795488,0.000023352917,0.000043072694,0.00007778235,0.00005698787],"domain_scores_gemma":[0.99993753,0.000008364575,0.000019821004,0.000009211551,0.000009807468,0.00001534788],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021303863,0.0003919607,0.0005060203,0.0001795492,0.00019070585,0.0002690984,0.00016382438,0.0002807407,0.0011082692],"category_scores_gemma":[0.00009669708,0.00017304892,0.00043216735,0.00022018378,0.00014957233,0.00015756603,0.00023753765,0.00043936353,0.0002068238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00071655336,0.00008794105,0.00077016314,0.00007962356,0.00003609424,0.00012795885,0.000022145294,0.00009404003,0.99562895,0.00003608185,0.000047426794,0.0023530386],"study_design_scores_gemma":[0.00012818718,0.0020552615,0.016428307,0.00001074277,0.0000734521,0.0005043104,0.00005323139,0.0005367568,0.9779816,0.000035778277,0.0021870856,0.0000052128644],"about_ca_topic_score_codex":0.0005230999,"about_ca_topic_score_gemma":0.0011156555,"teacher_disagreement_score":0.0011082692,"about_ca_system_score_codex":0.000329879,"about_ca_system_score_gemma":0.00023819853,"threshold_uncertainty_score":0.0037074685},"labels":[],"label_agreement":null},{"id":"W2130849618","doi":"10.1111/j.1365-2184.2007.00499.x","title":"Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells","year":2008,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Saskatchewan Health Research Foundation","keywords":"Trichostatin A; Histone deacetylase inhibitor; Molecular biology; Histone deacetylase; Biology; Cell culture; Chromatin immunoprecipitation; Myeloid; Myeloid leukemia; Apoptosis; Cancer research; Histone; Gene expression; Promoter; Gene; Biochemistry","score_opus":0.010956719178336214,"score_gpt":0.2635459521486961,"score_spread":0.25258923297035984,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2130849618","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9951368,0.0013692391,0.0016211367,0.00005168997,0.000016183398,0.00003785749,0.000742653,0.000053708736,0.0009707831],"genre_scores_gemma":[0.99312085,0.0008212396,0.002213524,0.000044098637,0.000012048126,0.00005928136,0.0021516816,0.0000075687963,0.0015695778],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998946,0.000015409652,0.000014783183,0.000019719153,0.00003305497,0.000022394008],"domain_scores_gemma":[0.9999238,0.000018319595,0.000016695698,0.000011998116,0.000013855707,0.000015282774],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010857247,0.0002192436,0.00021210125,0.00024960327,0.00012502489,0.0001740466,0.00012579946,0.00013520855,0.0009851509],"category_scores_gemma":[0.0001017328,0.00009485763,0.00020569416,0.00020915472,0.00013438387,0.0000754281,0.00012577596,0.00026887222,0.0003903926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021664755,0.000030463592,0.0011351724,0.000036370202,0.000007766989,0.00006404816,0.000021894924,0.000040624844,0.99709845,0.00003253386,0.000048952283,0.0012671074],"study_design_scores_gemma":[0.00003754269,0.0005942292,0.020701313,0.0000031278578,0.0000194625,0.0004104395,0.000028277698,0.00040660068,0.9758287,0.000016932421,0.0019509582,0.0000024240524],"about_ca_topic_score_codex":0.0008046481,"about_ca_topic_score_gemma":0.0011135314,"teacher_disagreement_score":0.0009851509,"about_ca_system_score_codex":0.00037707348,"about_ca_system_score_gemma":0.00019587218,"threshold_uncertainty_score":0.00329566},"labels":[],"label_agreement":null},{"id":"W2132090254","doi":"10.1158/1535-7163.mct-07-0560","title":"Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Romidepsin; Cancer research; Histone deacetylase; Histone deacetylase inhibitor; Biology; Cell growth; Cell cycle; Propidium iodide; Cell cycle checkpoint; Vorinostat; Apoptosis; Molecular biology; Programmed cell death; Histone; Biochemistry","score_opus":0.022626705361165556,"score_gpt":0.27782189018545866,"score_spread":0.2551951848242931,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2132090254","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99051476,0.0018399251,0.004055463,0.00009383469,0.000040231636,0.00016849476,0.0010191661,0.0001387394,0.0021293256],"genre_scores_gemma":[0.9852189,0.0025028114,0.005591583,0.00006911547,0.000015361682,0.00022194328,0.0023004627,0.000034302167,0.004045528],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997589,0.000038903898,0.00003122128,0.00003872755,0.00009290256,0.000039319493],"domain_scores_gemma":[0.99982053,0.00003527568,0.000048360234,0.000021048227,0.000032561944,0.00004222063],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020296489,0.0005024806,0.00039752602,0.00045972446,0.00014166792,0.00021195266,0.00028595925,0.00025832173,0.0013303307],"category_scores_gemma":[0.00014831798,0.00021117099,0.00035399568,0.00022582593,0.00018624814,0.00020315697,0.00017615057,0.0007254325,0.00037509532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024078839,0.00017323947,0.00028048726,0.00005415768,0.000012725526,0.00006258863,0.000024367284,0.00016292199,0.99736905,0.000080029786,0.00014768254,0.0013919639],"study_design_scores_gemma":[0.00006352976,0.0016987062,0.003569125,0.0000050066856,0.000022515664,0.0003072144,0.000029804578,0.0011761871,0.9913122,0.00003547894,0.0017753924,0.000004741433],"about_ca_topic_score_codex":0.0012528105,"about_ca_topic_score_gemma":0.0043273806,"teacher_disagreement_score":0.0013303307,"about_ca_system_score_codex":0.00034857885,"about_ca_system_score_gemma":0.00029242897,"threshold_uncertainty_score":0.004450321},"labels":[],"label_agreement":null},{"id":"W2135227533","doi":"10.1158/1535-7163.mct-08-0385","title":"Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"DNA damage; Fludarabine; Chemistry; SOD2; Molecular biology; Reactive oxygen species; Cancer research; Superoxide dismutase; Biology; Biochemistry; DNA; Oxidative stress; Genetics","score_opus":0.02381161412216235,"score_gpt":0.31750936273773106,"score_spread":0.2936977486155687,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2135227533","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98885626,0.0069310707,0.0022058354,0.000091172435,0.000030480805,0.000049485756,0.0002043121,0.0000710582,0.0015603278],"genre_scores_gemma":[0.99677247,0.0012480674,0.00067355443,0.000042695767,0.00001000238,0.000029826922,0.00020717202,0.000004965506,0.0010112254],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989986,0.00002244848,0.000008424332,0.000019267662,0.000021855265,0.000028157026],"domain_scores_gemma":[0.9999435,0.0000058205123,0.000024092153,0.0000052896694,0.000008746978,0.000012562298],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013865225,0.00031828342,0.00034606105,0.00013301885,0.00012842681,0.00030319765,0.00015253457,0.0002838,0.0009372512],"category_scores_gemma":[0.00009390175,0.00013244803,0.00017862896,0.00009062515,0.00012201346,0.00015954775,0.00016025155,0.00024527943,0.00021791064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003371965,0.000037429065,0.00077352335,0.000055905737,0.00001658904,0.0001139581,0.000021413298,0.000095242176,0.99479216,0.00011715255,0.0000460913,0.0035933193],"study_design_scores_gemma":[0.000084077474,0.0012984073,0.035004705,0.000013734266,0.00006580488,0.00072268257,0.00007442816,0.0015843724,0.9556375,0.00013602502,0.005367528,0.000010702032],"about_ca_topic_score_codex":0.00025000816,"about_ca_topic_score_gemma":0.00043244532,"teacher_disagreement_score":0.0009372512,"about_ca_system_score_codex":0.00030663455,"about_ca_system_score_gemma":0.000121198966,"threshold_uncertainty_score":0.0031354427},"labels":[],"label_agreement":null},{"id":"W2135938421","doi":"10.2174/156800911796798922","title":"Targeting Epigenetics through Histone Deacetylase Inhibitors in Acute Lymphoblastic Leukemia","year":2011,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Vorinostat; Histone deacetylase; Cancer research; Biology; Epigenetic therapy; Histone; Carcinogenesis; Leukemia; DNA methylation; Immunology; Cancer; Genetics; Gene expression; Gene","score_opus":0.03725352666084189,"score_gpt":0.36580973487302637,"score_spread":0.32855620821218445,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2135938421","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00034506907,0.9975431,0.00022910962,0.00021803036,0.00021106548,0.000009910423,0.000020640031,0.000014991689,0.0014080582],"genre_scores_gemma":[0.0010288788,0.99733114,0.00028690483,0.0001865016,0.00011678342,0.000010696101,0.00004083326,0.0000020648765,0.0009961623],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99987686,0.000017822986,0.00001681509,0.000021289252,0.00005511784,0.000012150581],"domain_scores_gemma":[0.9998753,0.000046368674,0.000022915576,0.0000039302863,0.00003628526,0.000015296133],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039525345,0.0007335491,0.0010993974,0.0015838946,0.0002171157,0.00054016657,0.00076794456,0.00078283314,0.002088331],"category_scores_gemma":[0.00036240104,0.0002646559,0.00038040947,0.0018250393,0.00029808204,0.00089396,0.0004086681,0.0016016505,0.0020602823],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012842407,0.000102549064,0.00014902101,0.0071579833,0.0000804979,0.0002831573,0.000041241812,0.00042601136,0.004346085,0.002421101,0.024709307,0.9601548],"study_design_scores_gemma":[0.00006554463,0.00023627694,0.00092723395,0.0010198733,0.00010960353,0.0019024182,0.000035778372,0.00015969027,0.0017935123,0.0011703351,0.9925605,0.000019266668],"about_ca_topic_score_codex":0.0008338443,"about_ca_topic_score_gemma":0.0021258055,"teacher_disagreement_score":0.002088331,"about_ca_system_score_codex":0.0005849074,"about_ca_system_score_gemma":0.0005128278,"threshold_uncertainty_score":0.006986201},"labels":[],"label_agreement":null},{"id":"W2136750459","doi":"10.1096/fj.13-246470","title":"Fam65b is important for formation of the HDAC6‐dysferlin protein complex during myogenic cell differentiation","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"Dysferlin; Biology; Muscular dystrophy; Cell biology; Myocyte; Zebrafish; Cellular differentiation; Skeletal muscle; Myogenin; Myogenesis; Genetics; Endocrinology; Gene","score_opus":0.013676765581972554,"score_gpt":0.24572896360686464,"score_spread":0.23205219802489208,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2136750459","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97285956,0.014121165,0.008395159,0.0002988336,0.00012901648,0.000040752773,0.0010999147,0.00023872031,0.002816841],"genre_scores_gemma":[0.9875043,0.0016447552,0.0037406012,0.00013719135,0.000015989377,0.00003153758,0.001844043,0.00004806651,0.0050335918],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982303,0.000014624167,0.000016853644,0.00005696824,0.000051615403,0.00003696566],"domain_scores_gemma":[0.99987686,0.0000068095687,0.000039458017,0.000008848837,0.000018124938,0.00004992858],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017006267,0.00041116885,0.00026426883,0.00034711754,0.0004451225,0.00032707874,0.00018441651,0.00039826526,0.0015258052],"category_scores_gemma":[0.00012394754,0.00023810066,0.00030718962,0.00021155753,0.00018945006,0.00022671801,0.00034148266,0.0004380629,0.0011312589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000056002416,0.000004627272,0.0004191778,0.000027812608,0.0000033661233,0.00007816853,0.000014727012,0.000011244009,0.9983931,0.00007597923,0.00007035366,0.0008453722],"study_design_scores_gemma":[0.000032410575,0.000109679524,0.037652552,0.000025282383,0.000029491395,0.001218891,0.00006729468,0.000909417,0.94019353,0.00010316889,0.019646294,0.000011987556],"about_ca_topic_score_codex":0.0014278119,"about_ca_topic_score_gemma":0.0022922975,"teacher_disagreement_score":0.0015258052,"about_ca_system_score_codex":0.0005859162,"about_ca_system_score_gemma":0.00019319972,"threshold_uncertainty_score":0.005104363},"labels":[],"label_agreement":null},{"id":"W2137168557","doi":"10.1111/j.1758-5872.2012.00205.x","title":"Associations of histone deacetylase‐2 and histone deacetylase‐3 genes with schizophrenia in a <scp>C</scp>hinese population","year":2012,"lang":"en","type":"article","venue":"Asia-Pacific Psychiatry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Single-nucleotide polymorphism; Haplotype; Transmission disequilibrium test; SNP; Histone deacetylase; Genetics; Allele; Population; Biology; Genotype; Gene; Molecular biology; Histone; Medicine","score_opus":0.01013915542155966,"score_gpt":0.2954082536598171,"score_spread":0.2852690982382574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2137168557","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99917245,0.00012987977,0.00013197504,0.000027105396,0.000004552841,0.000008213,0.00018530861,0.000003660998,0.0003367921],"genre_scores_gemma":[0.99890137,0.00010531128,0.00017516053,0.000023166624,0.000012039175,0.000016464628,0.00030364073,0.0000044739004,0.0004583732],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9997687,0.0000365406,0.000025730742,0.00009473293,0.000040927323,0.00003339964],"domain_scores_gemma":[0.99975556,0.000041529365,0.0000687824,0.00003283473,0.000039132356,0.00006227575],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003357574,0.00040817112,0.0003382494,0.0006788342,0.0007347405,0.00036589318,0.00023920994,0.00030456335,0.0036775651],"category_scores_gemma":[0.0004653814,0.00019650333,0.0003440949,0.00088941667,0.00029654772,0.00012995422,0.00022439817,0.0003501117,0.00026867414],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00053005555,0.000102263286,0.9840777,0.000026510143,0.00025286953,0.0011881816,0.00036624842,0.00010140091,0.009934136,0.00013632237,0.0002483876,0.0030359095],"study_design_scores_gemma":[0.000021076099,0.000092821116,0.9979407,0.0000056548447,0.000111263136,0.00068206683,0.00012149922,0.00025371125,0.00033760164,0.00007531809,0.00035256232,0.0000057221678],"about_ca_topic_score_codex":0.016532704,"about_ca_topic_score_gemma":0.014979099,"teacher_disagreement_score":0.016532704,"about_ca_system_score_codex":0.00024993307,"about_ca_system_score_gemma":0.00035923766,"threshold_uncertainty_score":0.032872975},"labels":[],"label_agreement":null},{"id":"W2137659055","doi":"10.1136/ard.2011.154211","title":"Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay","year":2011,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":208,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Italfarmaco; Universiteit van Amsterdam","keywords":"Medicine; Rheumatoid arthritis; Histone deacetylase; Cancer research; Messenger RNA; Fibroblast; Immunology; Histone; Gene; Cell culture; Genetics; Biology","score_opus":0.025956880234214514,"score_gpt":0.2758928229200386,"score_spread":0.24993594268582406,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2137659055","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9883357,0.004945409,0.003052988,0.00038798957,0.00028815016,0.000058164558,0.0004066819,0.00025592727,0.0022689225],"genre_scores_gemma":[0.99076676,0.0021503987,0.0022812115,0.00015815548,0.00012465526,0.000066336244,0.0003589118,0.000053282904,0.004040327],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973744,0.00005070134,0.00002960837,0.00003064646,0.000058834554,0.00009272761],"domain_scores_gemma":[0.9997688,0.000051999945,0.00006204757,0.000025731875,0.000024752759,0.00006664578],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000316823,0.0006325087,0.0003955309,0.00038141478,0.00021784291,0.00035490567,0.00022643566,0.00034459998,0.0018869352],"category_scores_gemma":[0.0002401414,0.00029512786,0.00046480948,0.00015169752,0.0004004975,0.00022741362,0.00015101314,0.0011901123,0.0005470787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001928318,0.00010576236,0.000107917265,0.00003568869,0.000008656255,0.000029603443,0.000010204601,0.000059228714,0.99543864,0.000074408,0.0000675047,0.0021341052],"study_design_scores_gemma":[0.0002747498,0.002078617,0.00187874,0.0000040790874,0.00003317617,0.00008664353,0.000024376663,0.0003794515,0.99390006,0.000056453195,0.0012777423,0.0000059119543],"about_ca_topic_score_codex":0.0005912554,"about_ca_topic_score_gemma":0.0015870596,"teacher_disagreement_score":0.0018869352,"about_ca_system_score_codex":0.00024151542,"about_ca_system_score_gemma":0.0003521731,"threshold_uncertainty_score":0.00631243},"labels":[],"label_agreement":null},{"id":"W2140937256","doi":"10.1093/jn/133.7.2485s","title":"Inhibition of Histone Deacetylase Activity by Butyrate","year":2003,"lang":"en","type":"review","venue":"Journal of Nutrition","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1455,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Research Manitoba","funders":"","keywords":"Sodium butyrate; Butyrate; Histone deacetylase 2; Histone deacetylase; Histone deacetylase 5; Acetylation; Histone; HDAC11; HDAC4; HDAC1; Cell biology; Histone deacetylase inhibitor; Chemistry; Chromatin; Biology; Cancer research; Biochemistry; Gene","score_opus":0.029002143314732182,"score_gpt":0.3688841441686987,"score_spread":0.3398820008539665,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2140937256","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00069016946,0.9936026,0.0012742532,0.00036532184,0.0010143853,0.00001307563,0.000041043913,0.000032102776,0.0029672047],"genre_scores_gemma":[0.0029260258,0.9919693,0.0007378676,0.00030830968,0.00028281027,0.000023124063,0.00007248319,0.0000057832217,0.0036742908],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998704,0.000009768084,0.000021997563,0.000030061887,0.000049104197,0.000018598115],"domain_scores_gemma":[0.99984956,0.00004793753,0.000027743956,0.000010383703,0.000047458816,0.000016870108],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004787313,0.0013802896,0.0015592878,0.0010511711,0.00028505336,0.00079920655,0.0009520956,0.0009318086,0.0024229886],"category_scores_gemma":[0.0003119183,0.00036960866,0.00039971765,0.001475617,0.00054023555,0.0008464334,0.0004314244,0.0016341918,0.0029166832],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00050776405,0.00013308506,0.0001879073,0.0074267588,0.00009794976,0.00038117805,0.00003415444,0.0005769963,0.04247099,0.003145856,0.019954452,0.925083],"study_design_scores_gemma":[0.00008758919,0.00024731565,0.0007952891,0.0006301586,0.00017125011,0.0011191313,0.000035997928,0.00014614854,0.02255915,0.0012740727,0.9729068,0.000027117001],"about_ca_topic_score_codex":0.0013088383,"about_ca_topic_score_gemma":0.0026083072,"teacher_disagreement_score":0.0024229886,"about_ca_system_score_codex":0.00076448097,"about_ca_system_score_gemma":0.0006620999,"threshold_uncertainty_score":0.008105695},"labels":[],"label_agreement":null},{"id":"W2141553911","doi":"10.1091/mbc.e08-07-0759","title":"A Histone Deacetylase 4/Myogenin Positive Feedback Loop Coordinates Denervation-dependent Gene Induction and Suppression","year":2008,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Centre National de la Recherche Scientifique; Muscular Dystrophy Association","keywords":"Myogenin; Biology; HDAC4; Myosin; Denervation; Cell biology; Myogenic regulatory factors; Myogenesis; Histone deacetylase; Myocyte; Endocrinology; Biochemistry; Gene; Histone","score_opus":0.009163204017177197,"score_gpt":0.2589559058841472,"score_spread":0.24979270186697,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2141553911","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97301066,0.0037846002,0.01844977,0.0002107871,0.00012258749,0.000043130323,0.00042556718,0.00052572665,0.003427057],"genre_scores_gemma":[0.98829556,0.0010483622,0.005370113,0.00007947253,0.000022126927,0.000032727374,0.0004913969,0.0000462341,0.0046140593],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984825,0.000017116154,0.000007622298,0.000046660185,0.00004377533,0.000036549678],"domain_scores_gemma":[0.99993134,0.000008593241,0.000022292677,0.0000091647025,0.000012664271,0.000015938316],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016544537,0.00048608327,0.00033222494,0.00024380517,0.00014494141,0.00026801636,0.00037157934,0.0001798554,0.0011958322],"category_scores_gemma":[0.00011062542,0.0002250652,0.00027319684,0.00013270971,0.00036352337,0.00016288622,0.00039163852,0.0003180156,0.00036393775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000582997,0.0000050061717,0.0001654255,0.000014156604,0.000004332485,0.000022693755,0.000004841009,0.000054180728,0.9983132,0.000139168,0.000034178367,0.0011845557],"study_design_scores_gemma":[0.000029158042,0.000099564124,0.006685395,0.0000035271187,0.000024912428,0.00010549798,0.000020081983,0.0017906526,0.9875316,0.00016081262,0.0035435166,0.0000052559126],"about_ca_topic_score_codex":0.00086935295,"about_ca_topic_score_gemma":0.0022263401,"teacher_disagreement_score":0.0011958322,"about_ca_system_score_codex":0.0006532506,"about_ca_system_score_gemma":0.0002951439,"threshold_uncertainty_score":0.0047397017},"labels":[],"label_agreement":null},{"id":"W2141920998","doi":"10.1093/annonc/mdn031","title":"Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid) in relapsed diffuse large-B-cell lymphoma","year":2008,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"U.S. Food and Drug Administration","keywords":"Medicine; Gastroenterology; Diffuse large B-cell lymphoma; Internal medicine; Vorinostat; Nausea; Adverse effect; Anemia; Tolerability; Neutropenia; Vomiting; Toxicity; Phases of clinical research; Surgery; Lymphoma","score_opus":0.04978978159332966,"score_gpt":0.3682998098545144,"score_spread":0.31851002826118474,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2141920998","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98963165,0.0038050462,0.00052755204,0.0008729545,0.00034135106,0.0009926718,0.00095957343,0.00018623844,0.0026829555],"genre_scores_gemma":[0.9898387,0.0025144361,0.0007442788,0.0006007692,0.00019699674,0.001070821,0.0018636867,0.00003478665,0.0031355335],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99974436,0.0000965492,0.000012120803,0.00004327284,0.000017457302,0.00008628777],"domain_scores_gemma":[0.99948066,0.000094713054,0.00004858946,0.0000439819,0.000017826052,0.00031420024],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010181109,0.0015299078,0.002881337,0.0005346251,0.0005967131,0.0010868288,0.0011000527,0.0013235279,0.0041032345],"category_scores_gemma":[0.00057895994,0.0005795465,0.0011572145,0.00050998636,0.0012385229,0.00088427006,0.00036093843,0.0033254134,0.0013237831],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.7573793,0.03974688,0.0036938882,0.0010976458,0.0013971726,0.000752514,0.0004225901,0.0044611264,0.051230185,0.00080134143,0.0061118426,0.13290553],"study_design_scores_gemma":[0.63891864,0.34456477,0.006283619,0.000042630567,0.00042745032,0.0004083023,0.00013003816,0.0016792158,0.0040121744,0.00034451656,0.003155436,0.000033344302],"about_ca_topic_score_codex":0.0018135019,"about_ca_topic_score_gemma":0.003998238,"teacher_disagreement_score":0.0041032345,"about_ca_system_score_codex":0.0010059965,"about_ca_system_score_gemma":0.0012667279,"threshold_uncertainty_score":0.013726711},"labels":[],"label_agreement":null},{"id":"W2142067446","doi":"10.1158/1535-7163.mct-09-0495","title":"Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Receptor; Histone deacetylase; Apoptosis; Programmed cell death; HDAC6; Histone; Histone deacetylase inhibitor; Biology; Chemistry; Cancer research; Cell biology; Pharmacology; Gene; Biochemistry","score_opus":0.014746398252306281,"score_gpt":0.31615507126264547,"score_spread":0.3014086730103392,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2142067446","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99380326,0.0011702243,0.0035040367,0.00006180846,0.000010602243,0.000022831826,0.0001155047,0.00006321902,0.0012485738],"genre_scores_gemma":[0.9959598,0.0010247461,0.0020284469,0.000023947752,0.000004462955,0.000019051415,0.00014686742,0.000008759418,0.000783887],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999341,0.000008394561,0.0000045100237,0.000013688417,0.000019582862,0.000019788942],"domain_scores_gemma":[0.999966,0.0000076208994,0.000011023699,0.000006132301,0.000003134311,0.0000061496307],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005171022,0.00021783212,0.00023756188,0.00019266992,0.00009207762,0.00020395796,0.00013149955,0.00012500248,0.00069181377],"category_scores_gemma":[0.00007255683,0.00012547479,0.0001893612,0.00011655111,0.0001623008,0.0001377723,0.00013829996,0.0002931595,0.00016018876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003008994,0.0000072502235,0.00011566157,0.000010939892,0.0000033258043,0.000016014057,0.000005268079,0.00009545269,0.99852306,0.000068953064,0.000010563912,0.0011133975],"study_design_scores_gemma":[0.0000068496515,0.00012104545,0.0019478614,0.0000011673844,0.000006820384,0.000070977505,0.000009354224,0.0005114479,0.9964766,0.000031562893,0.0008150116,0.0000013432181],"about_ca_topic_score_codex":0.0003389912,"about_ca_topic_score_gemma":0.00089458964,"teacher_disagreement_score":0.00069181377,"about_ca_system_score_codex":0.000233488,"about_ca_system_score_gemma":0.00011227745,"threshold_uncertainty_score":0.0023143291},"labels":[],"label_agreement":null},{"id":"W2142484115","doi":"10.1074/jbc.m312795200","title":"Inhibition of Histone Deacetylase Activity by Valproic Acid Blocks Adipogenesis","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Canadian Psychiatric Research Foundation","keywords":"Adipogenesis; Valproic Acid; Histone deacetylase; Histone deacetylase inhibitor; Chemistry; Histone; Pharmacology; Biology; Biochemistry; Neuroscience; Epilepsy; Adipose tissue; Gene","score_opus":0.016065823004829363,"score_gpt":0.29572829722114713,"score_spread":0.2796624742163178,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2142484115","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.990204,0.0056481436,0.0015447453,0.0001243288,0.00006340133,0.000018782352,0.00039793615,0.00012454702,0.0018741139],"genre_scores_gemma":[0.99330914,0.0037269946,0.0010626588,0.00004122921,0.000019988642,0.000017118402,0.00046990966,0.000020868994,0.0013320139],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991405,0.000015179857,0.000014427149,0.000014929586,0.000017632907,0.000023751349],"domain_scores_gemma":[0.99993587,0.000012256136,0.000019163952,0.00000830588,0.0000056824547,0.000018713308],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008309436,0.00031432346,0.00027798882,0.00012723143,0.00010956948,0.00024943246,0.00021476117,0.0001269113,0.0010699742],"category_scores_gemma":[0.000094605675,0.00010436738,0.00018048311,0.00012261588,0.00024032529,0.00011026061,0.00012547923,0.00044506244,0.00026378804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00045465693,0.000049209288,0.0002586808,0.00008468316,0.00001881436,0.000059900467,0.000011576642,0.00012323489,0.99361354,0.00011399277,0.00008375861,0.0051279585],"study_design_scores_gemma":[0.000056965484,0.000796112,0.0026572435,0.000006802137,0.000026430067,0.00014683476,0.0000133482,0.00032180114,0.99331784,0.00004539446,0.0026088352,0.0000024632886],"about_ca_topic_score_codex":0.00064832135,"about_ca_topic_score_gemma":0.0017456814,"teacher_disagreement_score":0.0010699742,"about_ca_system_score_codex":0.00023075147,"about_ca_system_score_gemma":0.0002502903,"threshold_uncertainty_score":0.0035793781},"labels":[],"label_agreement":null},{"id":"W2144153160","doi":"10.1016/j.leukres.2009.05.014","title":"Valproic acid exerts differential effects on CXCR4 expression in leukemic cells","year":2009,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Blood Services; University of Alberta","funders":"Canadian Institutes of Health Research; Canadian Blood Services","keywords":"CD34; CXCR4; Haematopoiesis; Progenitor cell; Cancer research; Stem cell; Histone deacetylase inhibitor; Cell culture; Chemistry; Biology; Histone deacetylase; Molecular biology; Receptor; Cell biology; Histone; Biochemistry; Chemokine; Genetics","score_opus":0.01772282883425628,"score_gpt":0.3261410201651962,"score_spread":0.3084181913309399,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2144153160","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9949157,0.0027121059,0.0002926412,0.00012584061,0.00004472323,0.00001038187,0.0004730574,0.0000453503,0.0013801552],"genre_scores_gemma":[0.99624974,0.0010973497,0.00032309897,0.00005153188,0.000016607848,0.000013634002,0.0006837782,0.000009897997,0.0015543178],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997956,0.0000480876,0.000025403611,0.000026796959,0.000033133972,0.000071046576],"domain_scores_gemma":[0.9999131,0.000019951358,0.000013936677,0.000015142076,0.000010357224,0.000027476974],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011790154,0.00030193015,0.0004466925,0.0003143801,0.00025099693,0.0005018593,0.00021005746,0.00026720727,0.0016853245],"category_scores_gemma":[0.00018688713,0.00016665708,0.00033719206,0.00037371903,0.0002580758,0.0002488896,0.00019147382,0.00061979314,0.00037750814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0029659509,0.00011149609,0.00074038404,0.00006511795,0.000024157558,0.0001484227,0.000049852155,0.00017861665,0.99092394,0.00020886467,0.00016517278,0.0044179857],"study_design_scores_gemma":[0.00015988185,0.0015512996,0.008604362,0.00000917442,0.00005184083,0.00038681575,0.00013049101,0.0004843643,0.98564076,0.000073750205,0.0028991767,0.000008049894],"about_ca_topic_score_codex":0.001668934,"about_ca_topic_score_gemma":0.0022853916,"teacher_disagreement_score":0.0016853245,"about_ca_system_score_codex":0.0003893282,"about_ca_system_score_gemma":0.00040628505,"threshold_uncertainty_score":0.0056379437},"labels":[],"label_agreement":null},{"id":"W2144611693","doi":"10.1158/0008-5472.can-08-2760","title":"PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A–Mediated Inactivation in Human Malignant Glioma","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"MAPK/ERK pathway; Kinase; Signal transduction; Phosphatase; Protein kinase A; Cell biology; Protein phosphatase 1; c-Raf; Cancer research; Biology; Protein phosphatase 2; Mitogen-activated protein kinase kinase; Phosphorylation; Chemistry","score_opus":0.03230272462130947,"score_gpt":0.3367391847315715,"score_spread":0.30443646011026204,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2144611693","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9968016,0.0017321045,0.00074950675,0.000045737543,0.000009757868,0.000013812944,0.00012878046,0.000031143092,0.00048755962],"genre_scores_gemma":[0.9966749,0.0011008063,0.0006049126,0.000018515319,0.000004310821,0.000019615096,0.00049144815,0.0000073336955,0.0010781491],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999397,0.000012666623,0.00000468733,0.000008120582,0.000016076607,0.000018815239],"domain_scores_gemma":[0.99995995,0.000008233319,0.000009265803,0.0000075524517,0.0000042889296,0.000010712374],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013026079,0.00027590423,0.00022302942,0.00021960992,0.000118024946,0.00015670029,0.00014649161,0.00013621898,0.0007433698],"category_scores_gemma":[0.000121697994,0.00013203896,0.00016548937,0.00014521062,0.00015407985,0.00011272651,0.00012922542,0.00033916807,0.0002402419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032704198,0.00010275133,0.00028919766,0.000041059528,0.000009294923,0.000055413166,0.000015864845,0.00013647033,0.99545395,0.00009298066,0.00006360437,0.0034123014],"study_design_scores_gemma":[0.00004497206,0.0010386381,0.005615968,0.000003493679,0.00001707561,0.0002665166,0.00001690341,0.00045560085,0.9908393,0.000053968277,0.001644311,0.00000316213],"about_ca_topic_score_codex":0.0005247839,"about_ca_topic_score_gemma":0.0006565693,"teacher_disagreement_score":0.0007433698,"about_ca_system_score_codex":0.00020962888,"about_ca_system_score_gemma":0.0001567858,"threshold_uncertainty_score":0.0024867654},"labels":[],"label_agreement":null},{"id":"W2145162000","doi":"10.1161/circulationaha.113.005300","title":"Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation","year":2013,"lang":"en","type":"article","venue":"Circulation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"HDAC6; Proteostasis; Acetylation; Medicine; Histone deacetylase; Histone deacetylase inhibitor; Contractility; Cell biology; Microtubule; HDAC4; Internal medicine; Cancer research; Pharmacology; Histone; Biology; Biochemistry","score_opus":0.02295494013413874,"score_gpt":0.3241158601854788,"score_spread":0.30116092005134004,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2145162000","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99232787,0.005031638,0.0011373978,0.00013153341,0.0000806769,0.000039548555,0.0002534505,0.00004697569,0.0009510301],"genre_scores_gemma":[0.9968953,0.0015190481,0.0003648122,0.000057874415,0.000024923256,0.00003734309,0.0004420524,0.0000056237436,0.00065286295],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9998934,0.000026012776,0.000014048212,0.000023626608,0.000016323274,0.000026540381],"domain_scores_gemma":[0.9999366,0.000009556517,0.000020573783,0.000009054851,0.000005890924,0.000018396197],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020810025,0.00027092,0.0002617797,0.00016230065,0.0001469243,0.00015868281,0.00012778866,0.00025083858,0.0019214236],"category_scores_gemma":[0.00015506959,0.00010137459,0.000286392,0.00014396785,0.00026932606,0.00008709609,0.00011553917,0.0004692285,0.00030365094],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002159151,0.00021396186,0.0020868408,0.00012762168,0.00003973804,0.00033378563,0.000032782114,0.000048787526,0.9906635,0.00008358714,0.00017063878,0.004039675],"study_design_scores_gemma":[0.00064589415,0.006878846,0.08961195,0.00002912107,0.0001631283,0.004581851,0.00010903727,0.0012220915,0.88987106,0.0001471114,0.006728209,0.000011691149],"about_ca_topic_score_codex":0.00024008872,"about_ca_topic_score_gemma":0.0003138749,"teacher_disagreement_score":0.0019214236,"about_ca_system_score_codex":0.00018239132,"about_ca_system_score_gemma":0.0001017755,"threshold_uncertainty_score":0.006427765},"labels":[],"label_agreement":null},{"id":"W2146029028","doi":"10.1186/s12950-014-0043-2","title":"The histone deacetylase Hdac1 regulates inflammatory signalling in intestinal epithelial cells","year":2014,"lang":"en","type":"article","venue":"Journal of Inflammation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation","keywords":"HDAC1; Histone deacetylase 2; Histone deacetylase; Cancer research; Molecular biology; Biology; Histone deacetylase 5; CXCL2; HDAC4; Chemokine; Cell biology; Chemistry; Histone; Inflammation; Immunology; Biochemistry; Chemokine receptor","score_opus":0.00635305888457188,"score_gpt":0.25304217408228985,"score_spread":0.24668911519771797,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2146029028","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86313295,0.10870202,0.012165103,0.0011646033,0.00046992608,0.00010772678,0.004155502,0.00065649435,0.009445575],"genre_scores_gemma":[0.974404,0.01785225,0.001995873,0.00019736466,0.0001088744,0.000047710397,0.0019901767,0.000056241097,0.003347503],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998373,0.000019079895,0.000011337263,0.00004153474,0.00003477898,0.000055937493],"domain_scores_gemma":[0.99986935,0.000011919206,0.00005034591,0.00001166971,0.000024606537,0.000032231983],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017103498,0.0005715219,0.00043695146,0.0002912495,0.00029129034,0.00053235434,0.0002882473,0.000276332,0.002559994],"category_scores_gemma":[0.000126335,0.00019237473,0.0004232583,0.00029591,0.00027059007,0.00026164667,0.00025182776,0.0005913726,0.0011681698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037188426,0.000038089533,0.001665964,0.0003327122,0.00003434002,0.00011181265,0.000032462653,0.00010860285,0.9893215,0.00019277955,0.00059407303,0.0071958974],"study_design_scores_gemma":[0.00010700304,0.00051400054,0.06074129,0.00009576409,0.00015996041,0.00087932684,0.00016673049,0.0017026609,0.9057844,0.00036170468,0.029464532,0.00002264048],"about_ca_topic_score_codex":0.00053406076,"about_ca_topic_score_gemma":0.0009969377,"teacher_disagreement_score":0.002559994,"about_ca_system_score_codex":0.00051653344,"about_ca_system_score_gemma":0.00023875922,"threshold_uncertainty_score":0.008563995},"labels":[],"label_agreement":null},{"id":"W2146432662","doi":"10.1186/1742-2094-9-113","title":"The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ","year":2012,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Fondation pour la Recherche sur Alzheimer","keywords":"Neurotoxicity; Neuroinflammation; Histone deacetylase; Astrocyte; Chemistry; Vorinostat; Histone deacetylase inhibitor; STAT3; Neurodegeneration; Pharmacology; Cancer research; Microglia; STAT protein; Cell biology; Phosphorylation; Biology; Immunology; Histone; Inflammation; Medicine; Biochemistry; Toxicity; Neuroscience; Central nervous system; Internal medicine","score_opus":0.01455144467821523,"score_gpt":0.29730483116032097,"score_spread":0.28275338648210574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2146432662","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9856938,0.009291864,0.0017376788,0.00021698946,0.00012556458,0.000060890816,0.00025499958,0.00011957005,0.0024985923],"genre_scores_gemma":[0.9934366,0.0039062984,0.00078239857,0.00006752651,0.000034996967,0.000035699748,0.00028563055,0.0000076212964,0.0014433257],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999597,0.0000066594735,0.000005048521,0.000005138,0.000010036582,0.000013453352],"domain_scores_gemma":[0.9999689,0.0000029740988,0.000010269192,0.0000035628618,0.000004925765,0.000009441163],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000059617945,0.00028095784,0.00023734613,0.00016114995,0.000102532875,0.00011362181,0.00015739919,0.00016011698,0.0014452114],"category_scores_gemma":[0.00006843089,0.000068477304,0.00019372691,0.000103989776,0.00013447668,0.00009599415,0.00009995776,0.00037971255,0.0002655433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008654327,0.0002087229,0.0002218822,0.00011924244,0.000025202646,0.00007021422,0.000018008892,0.00007082839,0.9915251,0.000056621706,0.00014758244,0.006671147],"study_design_scores_gemma":[0.00016811193,0.0021903398,0.005861707,0.000015734347,0.000054762677,0.00020645725,0.000034830064,0.000704355,0.9879353,0.000048092403,0.0027765017,0.000003936184],"about_ca_topic_score_codex":0.0007474017,"about_ca_topic_score_gemma":0.0014197214,"teacher_disagreement_score":0.0014452114,"about_ca_system_score_codex":0.00012533081,"about_ca_system_score_gemma":0.00022419779,"threshold_uncertainty_score":0.0048347116},"labels":[],"label_agreement":null},{"id":"W2147360810","doi":"10.1016/j.ajpath.2011.01.044","title":"Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism","year":2011,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Servier; Canadian Diabetes Association; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Vorinostat; Enos; Diabetic nephropathy; Pharmacology; Oxidative stress; Nephropathy; Endocrinology; Nitric oxide synthase; Histone deacetylase; Nitric Oxide Synthase Type III; Peroxynitrite; Histone deacetylase inhibitor; Nitric oxide; Internal medicine; Medicine; Diabetes mellitus; Chemistry; Histone; Biochemistry; Superoxide; Enzyme","score_opus":0.016631148746724916,"score_gpt":0.29934580721629234,"score_spread":0.28271465846956745,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2147360810","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9941859,0.0028891193,0.0011041437,0.00042754787,0.00027709792,0.000023311264,0.00016634306,0.00016073532,0.0007656751],"genre_scores_gemma":[0.9949934,0.0014152803,0.00076454435,0.000117347125,0.000100940306,0.000056142908,0.00035608263,0.000015613952,0.0021807402],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988306,0.00001670016,0.000011290479,0.00001412313,0.00002547962,0.000049266695],"domain_scores_gemma":[0.9997377,0.000020747633,0.00005960785,0.000035044253,0.000022484237,0.0001243899],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025603743,0.00042359997,0.0007625308,0.00024659513,0.00024457093,0.0004098848,0.00040372412,0.00035470407,0.0013822048],"category_scores_gemma":[0.00024265538,0.00017520948,0.00037671332,0.00019984132,0.00051922566,0.000585133,0.00018879799,0.0018287627,0.00024966418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.022395339,0.0025274665,0.001042152,0.00015808007,0.00012157638,0.00019572962,0.00005640917,0.00024814805,0.9525684,0.00045222594,0.0008168993,0.019417604],"study_design_scores_gemma":[0.0034488998,0.019307965,0.03215103,0.000045894132,0.00037366434,0.00034452454,0.00023746803,0.0031780936,0.9351161,0.00063858554,0.005107296,0.000050474206],"about_ca_topic_score_codex":0.0006149222,"about_ca_topic_score_gemma":0.0023209928,"teacher_disagreement_score":0.0013822048,"about_ca_system_score_codex":0.00038218824,"about_ca_system_score_gemma":0.0006832324,"threshold_uncertainty_score":0.0046239495},"labels":[],"label_agreement":null},{"id":"W2149247636","doi":"10.1158/0008-5472.can-07-5270","title":"Epigenetic Enhancement of Antigen Processing and Presentation Promotes Immune Recognition of Tumors","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Trichostatin A; Cancer research; Histone deacetylase; Immune system; Epigenetics; Biology; Antigen; MHC class I; Antigen presentation; Immunogenicity; Immunotherapy; Immunology; Major histocompatibility complex; Histone; T cell; Genetics","score_opus":0.06469056655122991,"score_gpt":0.3834948850328331,"score_spread":0.3188043184816032,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2149247636","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9832402,0.00484545,0.005762101,0.00034301874,0.00007484491,0.000022197533,0.00013159965,0.00016187852,0.0054186746],"genre_scores_gemma":[0.9950759,0.0014476409,0.0011610592,0.000065673834,0.000034354147,0.000008326908,0.00010299952,0.000015970221,0.002088067],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991584,0.000012731914,0.000004469962,0.000019004792,0.00002499367,0.00002297458],"domain_scores_gemma":[0.99994135,0.000010309405,0.000017336943,0.0000084663625,0.000008815478,0.000013722449],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234865,0.0001696851,0.00017293855,0.0001307789,0.00008158294,0.00026640802,0.000114158625,0.00015258738,0.0015435824],"category_scores_gemma":[0.00012115588,0.00009937271,0.00015373176,0.00008551921,0.00019181593,0.00016952629,0.00015893752,0.00032455372,0.0003568374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000044643024,0.000011876066,0.00020642726,0.00001770609,0.0000024889835,0.00003400839,0.0000058305463,0.00003264447,0.9970108,0.00018446721,0.000039085073,0.0024099064],"study_design_scores_gemma":[0.000016657106,0.00020317742,0.007276136,0.000003695877,0.000012492502,0.00022339117,0.000018517014,0.0005613047,0.98721504,0.00013293856,0.004334001,0.000002533254],"about_ca_topic_score_codex":0.00019228195,"about_ca_topic_score_gemma":0.00052515796,"teacher_disagreement_score":0.0015435824,"about_ca_system_score_codex":0.0002453054,"about_ca_system_score_gemma":0.00014487248,"threshold_uncertainty_score":0.005163789},"labels":[],"label_agreement":null},{"id":"W2149276366","doi":"10.2174/156800906778194586","title":"Development and Assessment of Conventional and Targeted Drug Combinations for Use in the Treatment of Aggressive Breast Cancers","year":2006,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Drug; Medicine; Intensive care medicine; Drug development; Pharmacology; Oncology","score_opus":0.05245195177791379,"score_gpt":0.39711500387024956,"score_spread":0.3446630520923358,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2149276366","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0004099397,0.99691784,0.0005272409,0.00019329072,0.00016264498,0.000023612705,0.000028932549,0.000016157352,0.0017203195],"genre_scores_gemma":[0.0014506439,0.9970464,0.0005907886,0.00015115933,0.000081882856,0.000022563081,0.000035423694,0.0000025412119,0.00061865395],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99976414,0.000040401897,0.000030013432,0.000038637005,0.00010369729,0.000023043238],"domain_scores_gemma":[0.99976844,0.00009887823,0.000043693803,0.00000811323,0.00006283453,0.000018065995],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00072709634,0.00087130547,0.0013186906,0.0022814958,0.00022646633,0.0010085593,0.0009689235,0.0009889845,0.0021706696],"category_scores_gemma":[0.000602618,0.00040636654,0.00053818844,0.0017126618,0.00052848697,0.0012427109,0.00052038435,0.001624684,0.001448854],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000090949114,0.00014433678,0.00015699005,0.015958391,0.00008839824,0.00024942085,0.00006208487,0.0009597474,0.007084557,0.0059136697,0.012148438,0.957143],"study_design_scores_gemma":[0.000034082626,0.0002789823,0.00065410626,0.0018937574,0.00009813985,0.0011485261,0.000043261647,0.00022312882,0.0026822677,0.0017539607,0.99116665,0.00002317507],"about_ca_topic_score_codex":0.000713146,"about_ca_topic_score_gemma":0.0013320296,"teacher_disagreement_score":0.0022814958,"about_ca_system_score_codex":0.00062561943,"about_ca_system_score_gemma":0.0008989649,"threshold_uncertainty_score":0.007261634},"labels":[],"label_agreement":null},{"id":"W2149477971","doi":"10.1073/pnas.1320850111","title":"Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Novo Nordisk Fonden","keywords":"Lysine; Chromatin; Diabetes mellitus; Cell biology; Acetylation; Cell; Chemistry; Cancer research; Medicine; Biology; Biochemistry; DNA; Endocrinology; Amino acid","score_opus":0.012596595366578213,"score_gpt":0.26065528791109804,"score_spread":0.24805869254451984,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2149477971","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99237,0.003412915,0.001993829,0.00012634802,0.000074917865,0.00003539713,0.00032498268,0.00022319274,0.00143846],"genre_scores_gemma":[0.99400073,0.0021713679,0.0012314585,0.00008029589,0.00002621085,0.000034715362,0.00065050245,0.000029024084,0.0017757998],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999936,0.000008057111,0.0000071836052,0.000014318959,0.00001432665,0.000020142961],"domain_scores_gemma":[0.99993634,0.000006502835,0.00002611623,0.000008845405,0.0000060751336,0.000016147094],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010411281,0.00034104622,0.00028516128,0.00018844008,0.000077598685,0.00016771782,0.00019820008,0.00017403945,0.0014684316],"category_scores_gemma":[0.000063625615,0.00010256221,0.00026132833,0.000108252316,0.00016541207,0.00013931595,0.00012696758,0.00054134225,0.00021303701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003947931,0.000070770766,0.00013707475,0.000051914696,0.000011137228,0.000019831812,0.000008835261,0.00003406123,0.9959352,0.00005563322,0.000050290873,0.003230363],"study_design_scores_gemma":[0.00014384606,0.0021528956,0.0052883425,0.000013342038,0.000039660565,0.00017159714,0.000025432675,0.0004013159,0.9884775,0.00007034634,0.0032098815,0.000005685094],"about_ca_topic_score_codex":0.00024521092,"about_ca_topic_score_gemma":0.000629147,"teacher_disagreement_score":0.0014684316,"about_ca_system_score_codex":0.000107589774,"about_ca_system_score_gemma":0.00013741569,"threshold_uncertainty_score":0.0049123764},"labels":[],"label_agreement":null},{"id":"W2150115389","doi":"10.1158/1078-0432.ccr-10-1893","title":"Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Decitabine; Medicine; Vorinostat; Neutropenia; Tolerability; Febrile neutropenia; Leukopenia; Internal medicine; Maximum tolerated dose; Adverse effect; Pharmacokinetics; Gastroenterology; Pharmacology; Oncology; Toxicity","score_opus":0.0606253614671827,"score_gpt":0.4430309267504193,"score_spread":0.38240556528323655,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2150115389","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99484384,0.0028580856,0.00040845535,0.00012918965,0.00003524715,0.00075514975,0.00020956455,0.00003932535,0.0007211505],"genre_scores_gemma":[0.9939756,0.0019340339,0.0014209872,0.00020243342,0.00008780531,0.0008052917,0.00070531113,0.000013215229,0.00085541315],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9997334,0.000113245726,0.000018100542,0.000042443906,0.00003865461,0.00005423649],"domain_scores_gemma":[0.99953794,0.00007643474,0.000109908164,0.000032221364,0.000025855603,0.0002177554],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006445088,0.00080795423,0.001960869,0.0002938501,0.00027955748,0.0005314256,0.0005621202,0.0005063957,0.0021099306],"category_scores_gemma":[0.00046978003,0.00035132255,0.000610122,0.00040208045,0.0005288737,0.0003613323,0.00026906966,0.0016662658,0.00040093486],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.45337534,0.08098493,0.024171846,0.0016810165,0.0020772675,0.00091541413,0.00046007612,0.0053100185,0.1871082,0.00030917578,0.0027862494,0.24082044],"study_design_scores_gemma":[0.20826164,0.7372478,0.02277401,0.000059939124,0.00073605514,0.001258089,0.00007356688,0.0015021332,0.022561457,0.0001449731,0.005351809,0.000028437258],"about_ca_topic_score_codex":0.00047135,"about_ca_topic_score_gemma":0.0011835159,"teacher_disagreement_score":0.0021099306,"about_ca_system_score_codex":0.0006282368,"about_ca_system_score_gemma":0.0011834579,"threshold_uncertainty_score":0.0070584416},"labels":[],"label_agreement":null},{"id":"W2150267627","doi":"10.1152/ajpgi.00393.2013","title":"The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis","year":2014,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institutes of Health","keywords":"Histone deacetylase 2; HDAC1; Biology; Inflammation; Cell biology; Colitis; Gene expression; Inflammatory bowel disease; Homeostasis; Cancer research; Histone; Immunology; Histone deacetylase; Biochemistry; Gene; Internal medicine; Medicine","score_opus":0.005704558774343623,"score_gpt":0.2361670371950798,"score_spread":0.2304624784207362,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2150267627","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9812231,0.012484139,0.0029698166,0.00016142246,0.00011562734,0.000038675087,0.00081396324,0.00013172417,0.0020614404],"genre_scores_gemma":[0.9894146,0.005046776,0.0013814069,0.00012948111,0.00004744465,0.0000651201,0.00088344887,0.000036622056,0.002995173],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978584,0.000024704786,0.000019673284,0.000051128376,0.000048834427,0.0000698096],"domain_scores_gemma":[0.99991727,0.000005002156,0.0000241652,0.000010519147,0.000011394461,0.000031560434],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015397837,0.0004717438,0.0005567239,0.00032602646,0.0001514495,0.00041827344,0.0001739346,0.00026281475,0.001716596],"category_scores_gemma":[0.00011719862,0.00020140357,0.0004058062,0.00022098466,0.0002706747,0.00027866842,0.0002086681,0.00073164346,0.0004385365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007908748,0.000046788675,0.001037584,0.00007120582,0.000026122734,0.00003476655,0.000017438242,0.000043131546,0.9951048,0.000070865,0.000075477925,0.002680979],"study_design_scores_gemma":[0.00015592159,0.0013998605,0.088703565,0.00003162451,0.00021158851,0.00047521782,0.00016250354,0.00096169405,0.8999626,0.00016480668,0.0077446154,0.000026116024],"about_ca_topic_score_codex":0.00033162907,"about_ca_topic_score_gemma":0.00091607193,"teacher_disagreement_score":0.001716596,"about_ca_system_score_codex":0.0002605419,"about_ca_system_score_gemma":0.00017356499,"threshold_uncertainty_score":0.00574255},"labels":[],"label_agreement":null},{"id":"W2151613376","doi":"10.1186/1475-2867-10-32","title":"Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination","year":2010,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Prostate Cancer Fight Foundation","keywords":"Cisplatin; Histone deacetylase inhibitor; Histone deacetylase; Cytotoxicity; ATF4; MTT assay; Viability assay; Cancer research; Activating transcription factor; ATF3; Chromatin immunoprecipitation; Apoptosis; Chemistry; Biology; Cell biology; Molecular biology; Histone; Unfolded protein response; Gene expression; Biochemistry; In vitro; Promoter; Genetics","score_opus":0.009684056325507931,"score_gpt":0.2740277748789932,"score_spread":0.26434371855348526,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2151613376","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98919106,0.0025395318,0.0054640523,0.00021729193,0.00006223832,0.00007064009,0.00087474677,0.0001573452,0.0014230941],"genre_scores_gemma":[0.99541146,0.0008675043,0.0021080023,0.000045415232,0.000011559218,0.00004132045,0.0005802601,0.000014971999,0.0009195712],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998919,0.000018995928,0.000010790696,0.000020015501,0.00003411297,0.000024214554],"domain_scores_gemma":[0.9999125,0.000017605824,0.000032400636,0.000011129404,0.00001037436,0.000015932075],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011839963,0.0004246554,0.00028211364,0.00025523824,0.00013743967,0.0001695785,0.0002308113,0.00025482097,0.0022049912],"category_scores_gemma":[0.00014895263,0.000107404245,0.00044765198,0.00020225938,0.00022256338,0.00020174109,0.00019121896,0.00050408073,0.00035938394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000303998,0.000054389602,0.00041026642,0.000043020056,0.000009479905,0.00005872921,0.0000068253266,0.00012085173,0.9968887,0.000048453145,0.00007801383,0.0019772456],"study_design_scores_gemma":[0.000026940206,0.0004990864,0.0049278946,0.000005758334,0.000031214848,0.00045753035,0.000017898496,0.00083685416,0.99127495,0.00005394851,0.0018636349,0.0000042755387],"about_ca_topic_score_codex":0.0004308708,"about_ca_topic_score_gemma":0.0006154082,"teacher_disagreement_score":0.0022049912,"about_ca_system_score_codex":0.00036531896,"about_ca_system_score_gemma":0.00026601233,"threshold_uncertainty_score":0.0073764324},"labels":[],"label_agreement":null},{"id":"W2153598858","doi":"10.1016/s1097-2765(03)00454-4","title":"Mechanism of SMRT Corepressor Recruitment by the BCL6 BTB Domain","year":2003,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":291,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Corepressor; Biology; BCL6; Psychological repression; Transcription factor; Repressor; Cell biology; Genetics; Histone deacetylase; Germinal center; Gene; Histone; B cell; Gene expression","score_opus":0.01685569203475642,"score_gpt":0.2676541220792922,"score_spread":0.2507984300445358,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2153598858","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9654049,0.0057163713,0.01581676,0.0009757414,0.00017399921,0.000098723045,0.0006887998,0.00054680917,0.010577991],"genre_scores_gemma":[0.9871421,0.0009290863,0.002533073,0.00012698177,0.000021866503,0.000042580683,0.00055553694,0.000036714195,0.008612038],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998561,0.00001535881,0.000007960101,0.000034734356,0.000037662136,0.000048124733],"domain_scores_gemma":[0.99991155,0.000015184814,0.0000181809,0.000012978615,0.000011996435,0.000029998857],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020940436,0.0002647783,0.00029581352,0.00018359383,0.00047799965,0.000550486,0.0004766172,0.00043186056,0.004232767],"category_scores_gemma":[0.00018342516,0.00023033185,0.00032321303,0.00013831619,0.00025303572,0.0006006515,0.00052984856,0.0006988685,0.0022715535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035400127,0.000029029734,0.0004310435,0.000087305874,0.000007800769,0.00018510719,0.000037101487,0.00019069135,0.9911582,0.0038040145,0.0005029077,0.00321285],"study_design_scores_gemma":[0.000055878747,0.000102351165,0.005815208,0.000018160335,0.0000075414873,0.0006104398,0.00006639114,0.004370618,0.9794597,0.00066821655,0.008810034,0.000015365147],"about_ca_topic_score_codex":0.0006852268,"about_ca_topic_score_gemma":0.0010223561,"teacher_disagreement_score":0.004232767,"about_ca_system_score_codex":0.00088761206,"about_ca_system_score_gemma":0.0002358669,"threshold_uncertainty_score":0.014159977},"labels":[],"label_agreement":null},{"id":"W2154618092","doi":"10.1186/1868-7083-4-5","title":"Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors","year":2012,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":503,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Manitoba Health Research Council","keywords":"Histone deacetylase; Epigenetics; Biology; Histone; Chromatin remodeling; Reprogramming; HDAC1; Chromatin; Transcription factor; Acetylation; Vorinostat; Histone deacetylase 5; Transcriptional regulation; Computational biology; Cell biology; Genetics; Gene","score_opus":0.05871680359192849,"score_gpt":0.4262477099212495,"score_spread":0.367530906329321,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2154618092","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.006232923,0.973756,0.0071587274,0.0059938203,0.00052849797,0.00002866544,0.00008804704,0.000059881953,0.0061534666],"genre_scores_gemma":[0.043375976,0.9462125,0.003857017,0.0026644005,0.0012244635,0.00008823563,0.00012215038,0.000024255269,0.002431056],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9992787,0.00022341478,0.000047931917,0.0001484783,0.00018426774,0.00011727904],"domain_scores_gemma":[0.9989415,0.0005441677,0.00010901345,0.000090244066,0.00018665653,0.00012855562],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0029566162,0.00079131767,0.0014321799,0.0010787351,0.0004447605,0.0020173206,0.0010259936,0.0011688966,0.0021931557],"category_scores_gemma":[0.0014032298,0.00038668865,0.00079250394,0.0010707068,0.0023196053,0.0033793543,0.0013829193,0.003748605,0.0009298416],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012928196,0.0008119909,0.0017911558,0.008348241,0.00032036475,0.0008192933,0.0007897889,0.0018640105,0.071674824,0.13151672,0.019643107,0.76112765],"study_design_scores_gemma":[0.00033549583,0.002798885,0.0037388825,0.0017249049,0.000284258,0.001871052,0.00057559425,0.0022421745,0.045506082,0.06411854,0.8766765,0.00012753645],"about_ca_topic_score_codex":0.00069179107,"about_ca_topic_score_gemma":0.0013236898,"teacher_disagreement_score":0.0029566162,"about_ca_system_score_codex":0.0013759925,"about_ca_system_score_gemma":0.0008513238,"threshold_uncertainty_score":0.015636265},"labels":[],"label_agreement":null},{"id":"W2155867875","doi":"10.1096/fj.14-249359","title":"Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"","keywords":"Histone deacetylase 5; Biology; Protein kinase A; Kinase; Phosphorylation; Cell biology; Histone deacetylase; Biochemistry; Histone; Gene","score_opus":0.01197302884148351,"score_gpt":0.26487631892263597,"score_spread":0.2529032900811525,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2155867875","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9854778,0.0051668044,0.006314893,0.00033598856,0.00011811416,0.000042752097,0.00046479094,0.00020267583,0.0018762111],"genre_scores_gemma":[0.99411255,0.0010174623,0.0019840642,0.00009407768,0.000021366572,0.00003149258,0.00047912836,0.000033726657,0.00222617],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997563,0.000030849726,0.000030487348,0.00007104303,0.000049096954,0.00006224711],"domain_scores_gemma":[0.99986076,0.0000139107315,0.000032467437,0.000034050645,0.000018101327,0.000040775987],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003147274,0.0004000495,0.00033931894,0.00023277824,0.00022473242,0.00039914824,0.00036173017,0.00023084915,0.0011760971],"category_scores_gemma":[0.00013923389,0.00017992419,0.00038782036,0.000128991,0.00036481398,0.0002268698,0.00034885877,0.0004896788,0.00041527775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007048707,0.000008094113,0.0003845279,0.000020386979,0.000005098689,0.00001807744,0.000004331351,0.000024085848,0.99826896,0.00006310194,0.000033569646,0.0010991973],"study_design_scores_gemma":[0.000016513266,0.00015095044,0.010935013,0.0000065767344,0.000025492742,0.0002559646,0.000021677894,0.0006593987,0.9849776,0.000055479588,0.002890776,0.000004502355],"about_ca_topic_score_codex":0.0006278358,"about_ca_topic_score_gemma":0.0015905632,"teacher_disagreement_score":0.0011760971,"about_ca_system_score_codex":0.00036113395,"about_ca_system_score_gemma":0.00023923274,"threshold_uncertainty_score":0.0039343834},"labels":[],"label_agreement":null},{"id":"W2157401351","doi":"10.1139/o01-032","title":"Class II histone deacetylases: Structure, function, and regulation","year":2001,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institute for Health and Care Research","keywords":"HDAC4; Histone deacetylase 5; Histone deacetylase 2; HDAC8; Acetylation; Biology; HDAC11; Histone deacetylase; Cell biology; Histone; HDAC1; HDAC10; Corepressor; Histone code; SAP30; Mef2; Transcription factor; Biochemistry; Nucleosome; Enhancer; Repressor","score_opus":0.0066740250460679456,"score_gpt":0.24702683492567398,"score_spread":0.24035280987960603,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2157401351","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.13771272,0.78311026,0.039362375,0.0031319372,0.0020720395,0.00019105886,0.0025978594,0.0009557919,0.030866042],"genre_scores_gemma":[0.57572174,0.34067753,0.014066014,0.0012176972,0.0012731393,0.00013582858,0.0042339787,0.00012450681,0.0625496],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998104,0.000010965022,0.000009821805,0.000061146675,0.00006869,0.000039137936],"domain_scores_gemma":[0.99992025,0.0000031502536,0.000023310835,0.000007779038,0.000023054177,0.000022412145],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019672305,0.00049781287,0.00041316287,0.0002635286,0.00033072042,0.0011966999,0.0004521669,0.00035358386,0.0016760454],"category_scores_gemma":[0.00016573272,0.00013498789,0.00016716955,0.0005401207,0.00035037912,0.0004991169,0.00036380903,0.00048789478,0.002214623],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037442977,0.00012097564,0.006047239,0.0010097247,0.00008042331,0.0003150077,0.00012165801,0.0005488645,0.50128794,0.015078193,0.014894546,0.46012095],"study_design_scores_gemma":[0.00008198193,0.0002769175,0.040079687,0.000112883194,0.000104463026,0.002190556,0.00013900637,0.0012258048,0.22790718,0.008436749,0.7193958,0.000048982838],"about_ca_topic_score_codex":0.0015981757,"about_ca_topic_score_gemma":0.0015510937,"teacher_disagreement_score":0.0016760454,"about_ca_system_score_codex":0.0006602077,"about_ca_system_score_gemma":0.00053894357,"threshold_uncertainty_score":0.0056069493},"labels":[],"label_agreement":null},{"id":"W2157917711","doi":"10.1158/0008-5472.can-06-0402","title":"Restoration of Tamoxifen Sensitivity in Estrogen Receptor–Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Institutes of Health; Breast Cancer Research Foundation","keywords":"Trichostatin A; Corepressor; Tamoxifen; Cancer research; Estrogen receptor; Histone deacetylase; Chromatin immunoprecipitation; Breast cancer; Estrogen receptor alpha; Biology; Antiestrogen; Cancer; Chemistry; Histone; Nuclear receptor; Promoter; Gene expression; Transcription factor; Genetics; Gene","score_opus":0.042521618632506274,"score_gpt":0.36494312473919327,"score_spread":0.322421506106687,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2157917711","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9905325,0.0030363044,0.0034030383,0.000194637,0.000047798076,0.000055279575,0.0005757079,0.0001796291,0.0019750744],"genre_scores_gemma":[0.9903403,0.0019184928,0.0025520464,0.000117720694,0.000011611504,0.000059638493,0.0012132229,0.000036672056,0.0037504048],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999882,0.000017887545,0.0000126655295,0.00002147527,0.00003604167,0.000030051831],"domain_scores_gemma":[0.99993944,0.0000127983785,0.000013561775,0.000013231935,0.00000642376,0.000014543335],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000121470046,0.0002527129,0.00025825694,0.00013484455,0.00009849599,0.00024003471,0.00021834094,0.00020015254,0.0012523428],"category_scores_gemma":[0.00011622892,0.00013694374,0.00021866281,0.00013414625,0.00017702141,0.00012022517,0.00014907299,0.0004504096,0.00046573198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000025729038,0.000008666859,0.00007833803,0.000011352579,0.0000022945121,0.000018326931,0.0000050890203,0.0000097089405,0.9992163,0.00002708648,0.000019974528,0.00057711685],"study_design_scores_gemma":[0.00001670311,0.00015103341,0.0052164258,0.0000026871287,0.00001056703,0.0002153803,0.0000140256325,0.00035651776,0.9912027,0.000017674975,0.0027938655,0.0000025607576],"about_ca_topic_score_codex":0.0006219898,"about_ca_topic_score_gemma":0.0013173423,"teacher_disagreement_score":0.0012523428,"about_ca_system_score_codex":0.00022111955,"about_ca_system_score_gemma":0.00017497843,"threshold_uncertainty_score":0.004189551},"labels":[],"label_agreement":null},{"id":"W2158898951","doi":"10.1371/journal.pone.0041033","title":"Toll-Like Signaling and the Cytokine IL-6 Regulate Histone Deacetylase Dependent Neuronal Survival","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Histone deacetylase; Cell biology; Signal transduction; Biology; Cytokine; Histone deacetylase inhibitor; Receptor; Cancer research; Histone; Immunology; Biochemistry","score_opus":0.02973787025419298,"score_gpt":0.25829963302718284,"score_spread":0.22856176277298987,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2158898951","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96986157,0.01776414,0.007302371,0.00035314905,0.00011287192,0.000041699535,0.000694704,0.000101033496,0.0037685689],"genre_scores_gemma":[0.9875321,0.0053976164,0.003539722,0.00011255168,0.000027592183,0.00003719274,0.00048470122,0.000012958392,0.0028555638],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998739,0.000019485875,0.000010932472,0.000024403076,0.000029376082,0.0000419188],"domain_scores_gemma":[0.9999316,0.000008661342,0.000023971521,0.000007936582,0.00001108128,0.000016787006],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109069435,0.00028322454,0.00022088102,0.000166483,0.00012818126,0.00028172985,0.00016508621,0.00021962624,0.0014360688],"category_scores_gemma":[0.000104790204,0.00014234116,0.00030729888,0.00010548931,0.00021161401,0.00020084057,0.00016850344,0.00041096998,0.00043424888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019023202,0.000014284473,0.00028262698,0.000042623808,0.000008113874,0.00002835864,0.0000073641954,0.000038541897,0.9970921,0.00009345103,0.000037981292,0.002164439],"study_design_scores_gemma":[0.000020317153,0.0002063666,0.011986699,0.000006332131,0.00001820669,0.00014316972,0.000027778653,0.00040274032,0.9846352,0.000106160165,0.0024428226,0.000004313298],"about_ca_topic_score_codex":0.00030962005,"about_ca_topic_score_gemma":0.0010886566,"teacher_disagreement_score":0.0014360688,"about_ca_system_score_codex":0.00027023713,"about_ca_system_score_gemma":0.00018936247,"threshold_uncertainty_score":0.0048040748},"labels":[],"label_agreement":null},{"id":"W2159887222","doi":"10.1210/en.2014-1565","title":"Inactivation of Histone Deacetylase 1 (HDAC1) But Not HDAC2 Is Required for the Glucocorticoid-Dependent CCAAT/Enhancer-Binding Protein α (C/EBPα) Expression and Preadipocyte Differentiation","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"York University; NOSM University; Health Canada","funders":"Canadian Institutes of Health Research","keywords":"Adipogenesis; Trichostatin A; HDAC1; Ccaat-enhancer-binding proteins; Histone deacetylase 2; Glucocorticoid receptor; Histone deacetylase; Biology; Transcription factor; Molecular biology; Internal medicine; Endocrinology; Chemistry; Glucocorticoid; Cancer research; Histone; Biochemistry; Adipose tissue; Medicine; Nuclear protein","score_opus":0.018173664688418203,"score_gpt":0.30681630317771047,"score_spread":0.2886426384892923,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2159887222","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98449266,0.006425498,0.005438917,0.00028595186,0.0001452623,0.00003927882,0.0008927498,0.00014800011,0.0021315746],"genre_scores_gemma":[0.9905828,0.0025808383,0.0023344122,0.00012444303,0.000029828865,0.000037968184,0.0008714123,0.000037285303,0.0034009318],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985886,0.000009852227,0.000015517047,0.000043790245,0.000030739462,0.00004122223],"domain_scores_gemma":[0.9999107,0.000011458101,0.00002998839,0.0000107808,0.000009172714,0.000027798067],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011684077,0.00038183318,0.00037766673,0.00017175535,0.0002404704,0.0003724486,0.00020772856,0.00021218295,0.0014408606],"category_scores_gemma":[0.00009296375,0.00020410347,0.00049332844,0.00014474874,0.00026629935,0.00016261976,0.0001685997,0.0006188246,0.00047199157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009290037,0.000015970947,0.00029273954,0.000033816683,0.00000541562,0.00004185172,0.000009511999,0.0000307878,0.9984919,0.000052524818,0.0000341559,0.0008986104],"study_design_scores_gemma":[0.000020143854,0.00010823123,0.012084331,0.0000041766407,0.000020510364,0.00025520512,0.000023894445,0.00042058819,0.98427147,0.000027996164,0.0027577258,0.00000576818],"about_ca_topic_score_codex":0.0013923845,"about_ca_topic_score_gemma":0.002811324,"teacher_disagreement_score":0.0014408606,"about_ca_system_score_codex":0.00036547222,"about_ca_system_score_gemma":0.0003400808,"threshold_uncertainty_score":0.0048201084},"labels":[],"label_agreement":null},{"id":"W2159887704","doi":"10.1186/1476-4598-5-71","title":"Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B","year":2006,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Histone deacetylase; Protein kinase B; Biology; Cancer research; Histone deacetylase 5; Histone deacetylase inhibitor; Butyrate; Cell biology; Acetylation; Sodium butyrate; Histone; Signal transduction; Biochemistry","score_opus":0.01121131253411658,"score_gpt":0.2787686466445616,"score_spread":0.267557334110445,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2159887704","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97070056,0.021113114,0.0021377988,0.000398947,0.00021418526,0.0001304843,0.0010920338,0.00011531299,0.00409751],"genre_scores_gemma":[0.9842733,0.008983609,0.0016773663,0.00014519642,0.000024796203,0.00008650821,0.0012983637,0.000010830221,0.0035000416],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999149,0.000011588858,0.000012563821,0.000013564274,0.000024228717,0.000023185356],"domain_scores_gemma":[0.9999676,0.0000051166476,0.00000922155,0.00000541617,0.000004897747,0.000007848995],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007861687,0.0003496492,0.00023091763,0.00017338966,0.00016083894,0.00019800062,0.00012824155,0.00018395411,0.0017315197],"category_scores_gemma":[0.000059136088,0.00011832695,0.00028267154,0.00021838193,0.00012968264,0.00010376384,0.0001256169,0.00040806315,0.0004215498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008798898,0.00012825588,0.00045545655,0.00018175511,0.00002557599,0.00009742976,0.000017437835,0.00013894668,0.9923333,0.000120157645,0.00022146243,0.0054003615],"study_design_scores_gemma":[0.00018993384,0.0015470581,0.007146398,0.000018746674,0.00004910652,0.00050789735,0.00003709796,0.00049784576,0.9807608,0.000091163936,0.009148759,0.0000051447655],"about_ca_topic_score_codex":0.0007638646,"about_ca_topic_score_gemma":0.001369795,"teacher_disagreement_score":0.0017315197,"about_ca_system_score_codex":0.00022427861,"about_ca_system_score_gemma":0.00034447547,"threshold_uncertainty_score":0.0057924986},"labels":[],"label_agreement":null},{"id":"W2160371692","doi":"10.1139/bcb-2014-0119","title":"Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophy","year":2014,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Bromodomain; Histone; Epigenetics; Acetylation; Lysine; Histone Acetyltransferases; Biology; BRD4; Biochemistry; Bioinformatics; Cell biology; Computational biology; Cancer research; Genetics; Gene; Amino acid","score_opus":0.011561355446725298,"score_gpt":0.25661725653350376,"score_spread":0.24505590108677847,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2160371692","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00015473345,0.9984144,0.0001182021,0.0002153991,0.00018942147,0.0000032154476,0.000012779822,0.000007945319,0.0008837879],"genre_scores_gemma":[0.0008403414,0.99792886,0.00014347852,0.00013977563,0.00013336909,0.00000501169,0.000022351198,0.0000014426428,0.0007853716],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998883,0.00001672575,0.000016430426,0.000021006057,0.000044808647,0.000012642789],"domain_scores_gemma":[0.9998685,0.000045818277,0.000023140961,0.000004785834,0.00003820156,0.000019523699],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003372573,0.0007003513,0.0010008314,0.0016479933,0.0002608546,0.00063384086,0.00066000986,0.0009462712,0.0027699422],"category_scores_gemma":[0.00036303973,0.0002583242,0.00032889892,0.0015865103,0.0004247684,0.0009630403,0.0005424248,0.0013836352,0.0020086218],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012256697,0.000071489485,0.00021252937,0.010862386,0.00009531471,0.0002524949,0.000057737794,0.00035373055,0.004944615,0.004954005,0.027097717,0.9509755],"study_design_scores_gemma":[0.00002037718,0.00009089746,0.0008824842,0.0011520784,0.000064897264,0.0012331582,0.00004180037,0.00007990612,0.0008402834,0.001953808,0.99362516,0.0000151231025],"about_ca_topic_score_codex":0.0006628206,"about_ca_topic_score_gemma":0.0013914428,"teacher_disagreement_score":0.0027699422,"about_ca_system_score_codex":0.00052299217,"about_ca_system_score_gemma":0.000647059,"threshold_uncertainty_score":0.0092663765},"labels":[],"label_agreement":null},{"id":"W2160646902","doi":"10.1139/o02-021","title":"Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa","year":2002,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"National Science Foundation","keywords":"Trichostatin A; Acetylation; Histone; Histone H4; HDAC4; Histone deacetylase; Histone H3; Histone methyltransferase; Histone H2A; Histone deacetylase 2; Chromatin; Biochemistry; Chemistry; Chromatin remodeling; Molecular biology; Biology; Gene","score_opus":0.01410747263523614,"score_gpt":0.2771120044820738,"score_spread":0.26300453184683764,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2160646902","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98741233,0.002384775,0.00533451,0.000050472783,0.000031695497,0.00003638085,0.0030144711,0.00012951047,0.0016059013],"genre_scores_gemma":[0.9838346,0.001523462,0.0031455017,0.00007382527,0.000015519146,0.000105522144,0.00520239,0.00009143841,0.006007653],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998703,0.000012074839,0.000011183771,0.000038370978,0.000037387686,0.00003055428],"domain_scores_gemma":[0.9997671,0.00005104411,0.000052494037,0.00002653599,0.000064554355,0.000038245733],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017527884,0.00029689792,0.00038954034,0.0003699566,0.00014208934,0.00030118696,0.00025714468,0.00020722451,0.0006271076],"category_scores_gemma":[0.00015954975,0.00020957313,0.00036959458,0.0004691967,0.00010695374,0.00016607124,0.00010467147,0.0005375466,0.00041857638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014599357,0.000008790368,0.00040766248,0.000019912628,0.000006389429,0.000016796843,0.000018944744,0.000059173908,0.99842334,0.000018643672,0.00002431287,0.00084991707],"study_design_scores_gemma":[0.000009768858,0.00028321755,0.037073843,0.000007024471,0.000033302465,0.00009937986,0.00007254882,0.0026420741,0.95764107,0.000045323886,0.0020706544,0.000021763131],"about_ca_topic_score_codex":0.0043200273,"about_ca_topic_score_gemma":0.0031466954,"teacher_disagreement_score":0.0043200273,"about_ca_system_score_codex":0.0005802894,"about_ca_system_score_gemma":0.00017930882,"threshold_uncertainty_score":0.008589745},"labels":[],"label_agreement":null},{"id":"W2162787110","doi":"10.1128/mcb.01154-06","title":"Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally","year":2008,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":555,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institut National Du Cancer; Université de Fribourg; Dalhousie University; Ellison Medical Foundation; Howard Hughes Medical Institute","keywords":"Biology; HDAC6; Acetylation; Histone deacetylase; Tubulin; Cell biology; Histone; Histone deacetylase 5; Molecular biology; Microtubule; Biochemistry; Gene","score_opus":0.011482246533664139,"score_gpt":0.2488475263652321,"score_spread":0.23736527983156797,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2162787110","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92095584,0.008281308,0.024796508,0.0017869978,0.0006614648,0.00024331262,0.017164929,0.0070565133,0.019053258],"genre_scores_gemma":[0.84077615,0.005750869,0.015317234,0.00067716447,0.00018801363,0.0004199432,0.015423785,0.0014091303,0.120037615],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99930704,0.000046533594,0.00006917179,0.00020706415,0.00025424865,0.0001159497],"domain_scores_gemma":[0.9984459,0.00013067595,0.00069604075,0.0001379179,0.000117958196,0.000471477],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003695026,0.0023970876,0.00087813695,0.0021533514,0.00048020273,0.000837305,0.0010002156,0.0019864286,0.01073535],"category_scores_gemma":[0.0003808736,0.00069288,0.0005719014,0.0006069616,0.0010639217,0.00066824746,0.0006182457,0.0018860409,0.004930348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042208662,0.00013708178,0.0006523744,0.0000831122,0.0000447755,0.0011148853,0.000053092215,0.00013534681,0.9897239,0.0010496957,0.0007217085,0.005861954],"study_design_scores_gemma":[0.00048946316,0.002167413,0.027943961,0.00012378389,0.0002468752,0.015252614,0.00016542769,0.0018137273,0.8982098,0.0019058972,0.051583596,0.000097373086],"about_ca_topic_score_codex":0.00071247626,"about_ca_topic_score_gemma":0.0014678981,"teacher_disagreement_score":0.01073535,"about_ca_system_score_codex":0.0005533622,"about_ca_system_score_gemma":0.00040725523,"threshold_uncertainty_score":0.03591335},"labels":[],"label_agreement":null},{"id":"W2163464088","doi":"","title":"Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines.","year":2011,"lang":"en","type":"article","venue":"PubMed","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Cancer Foundation; University of Alberta","funders":"","keywords":"Apoptosis; Cancer research; Pancreatic cancer; Cell culture; Bortezomib; Chemistry; Cell growth; Biology; Cancer; Molecular biology; Biochemistry; Immunology; Multiple myeloma","score_opus":0.024349307102712065,"score_gpt":0.2526037392688594,"score_spread":0.2282544321661473,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2163464088","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96972185,0.019707913,0.0031680884,0.00029093077,0.00016370711,0.00011342537,0.0011818373,0.00022547864,0.005426883],"genre_scores_gemma":[0.99043673,0.0037259813,0.0022384026,0.000080305195,0.000031212163,0.00006958836,0.0010842335,0.000015412172,0.0023181732],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997838,0.000045441175,0.000021193282,0.000039343653,0.00006919377,0.000040923413],"domain_scores_gemma":[0.99991083,0.000017590239,0.000019908965,0.000012772176,0.000014223289,0.000024730081],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545653,0.00039572548,0.00048422554,0.00030560695,0.00016184892,0.00023052254,0.00018858444,0.00019835036,0.002331473],"category_scores_gemma":[0.00011629035,0.00016653507,0.00035269876,0.0002918733,0.0001275683,0.00020051013,0.00021652381,0.00039363786,0.00055261375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007026558,0.00012921785,0.00046824606,0.00018470685,0.00004272925,0.00005635245,0.000013039506,0.00010851285,0.99173003,0.0000545188,0.00022273228,0.006287401],"study_design_scores_gemma":[0.00009491824,0.0025653273,0.0063321274,0.000009710001,0.00009269594,0.00052535196,0.000028733864,0.0003578242,0.98492706,0.000023787588,0.0050360155,0.0000066035714],"about_ca_topic_score_codex":0.00042553173,"about_ca_topic_score_gemma":0.0018043821,"teacher_disagreement_score":0.002331473,"about_ca_system_score_codex":0.0002684552,"about_ca_system_score_gemma":0.0002893001,"threshold_uncertainty_score":0.007799506},"labels":[],"label_agreement":null},{"id":"W2164382188","doi":"","title":"Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":510,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Pharmacokinetics; Depsipeptide; Nausea; Refractory (planetary science); Vomiting; Toxicity; Maximum tolerated dose; Internal medicine; Pharmacology; Gastroenterology","score_opus":0.014042610643771193,"score_gpt":0.24234960807561398,"score_spread":0.2283069974318428,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2164382188","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9919218,0.0030910438,0.00039363664,0.00031230316,0.000074497526,0.001293197,0.00055680214,0.000096775984,0.0022599155],"genre_scores_gemma":[0.9867154,0.0028465271,0.0016338873,0.0007555973,0.0001828725,0.0018342173,0.0027067869,0.00002536657,0.0032994417],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.9998648,0.000045631554,0.000010804348,0.000024312425,0.000019045714,0.000035313835],"domain_scores_gemma":[0.99971193,0.00004557196,0.00006742554,0.000015831138,0.00001667846,0.0001424979],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004993608,0.0013152725,0.0015549577,0.00031712037,0.00028784992,0.00046282323,0.0006174913,0.0007438496,0.00246609],"category_scores_gemma":[0.00035415482,0.00025960512,0.0004899694,0.00033088817,0.0004288046,0.00038562808,0.00026137964,0.0016652993,0.0006814298],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.44866315,0.0400783,0.012325672,0.0021682587,0.0014118281,0.0016455373,0.00049555505,0.005598045,0.17337243,0.0006090495,0.012834382,0.30079782],"study_design_scores_gemma":[0.39569935,0.5538434,0.017349482,0.00010584624,0.0007347777,0.0019672522,0.00011402545,0.0029618759,0.01762332,0.00031977246,0.009247132,0.000033784803],"about_ca_topic_score_codex":0.0009260927,"about_ca_topic_score_gemma":0.0031107024,"teacher_disagreement_score":0.00246609,"about_ca_system_score_codex":0.0007030637,"about_ca_system_score_gemma":0.0010743625,"threshold_uncertainty_score":0.008249879},"labels":[],"label_agreement":null},{"id":"W2165074304","doi":"10.1093/neuonc/nou253.28","title":"ED-28 * EFFECT OF VALPROIC ACID EXPOSURE ON SURVIVAL IN LOW-GRADE GLIOMA PATIENTS: A RETROSPECTIVE ANALYSIS","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"","keywords":"Valproic Acid; Medicine; Retrospective cohort study; Anticonvulsant; Glioma; Internal medicine; Medical prescription; Histone deacetylase inhibitor; Oncology; Epilepsy; Pediatrics; Pharmacology; Histone deacetylase; Psychiatry; Cancer research","score_opus":0.005730372881801133,"score_gpt":0.27745380481209575,"score_spread":0.27172343193029463,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2165074304","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9966151,0.00035510957,0.00003506009,0.000017140734,0.0000030403255,0.000010245699,0.0023525662,0.0000030153108,0.00060868793],"genre_scores_gemma":[0.998338,0.00012420284,0.00002604511,0.000019451878,0.0000032715038,0.0000102278245,0.0013548867,0.0000015296059,0.00012245687],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9996333,0.000050870993,0.00006660859,0.000098134784,0.00007172044,0.00007930905],"domain_scores_gemma":[0.99890256,0.00015050244,0.0004896588,0.00007753107,0.00021910196,0.00016059495],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003837177,0.00017179533,0.00028491643,0.0010642908,0.0003903621,0.00040939043,0.00032638444,0.00026528467,0.0016671395],"category_scores_gemma":[0.0011535458,0.00016512338,0.0004746927,0.0018201839,0.00024494407,0.0002523005,0.00028691234,0.00027487366,0.00027157634],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000726006,0.0000055584937,0.99947876,0.0000063661087,0.000025676223,0.000046239642,0.000012651611,0.000014785958,0.000036992173,0.0000033556346,0.00004565546,0.00025144385],"study_design_scores_gemma":[0.0000046089253,0.000054658198,0.9992601,0.0000057114735,0.000032039607,0.00020368052,0.00009012885,0.0000615294,0.000041283678,0.000005982908,0.00023813052,0.000002147505],"about_ca_topic_score_codex":0.031365324,"about_ca_topic_score_gemma":0.028809173,"teacher_disagreement_score":0.031365324,"about_ca_system_score_codex":0.0008721689,"about_ca_system_score_gemma":0.00062625745,"threshold_uncertainty_score":0.062365532},"labels":[],"label_agreement":null},{"id":"W2168448928","doi":"10.1038/nrm2346","title":"The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men","year":2008,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1214,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; American Heart Association","keywords":"Biology; HDAC4; Chromatin; Histone; Genetics; Histone deacetylase; Cell biology; Histone H4; Histone deacetylase 5; Histone deacetylase 2; Multiprotein complex; Epigenetics; DNA; Gene","score_opus":0.014014839759060007,"score_gpt":0.3173181656081127,"score_spread":0.30330332584905273,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2168448928","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00016653637,0.9965095,0.00065371534,0.00047723,0.00076063466,0.0000057847355,0.000035873036,0.00003118954,0.0013594467],"genre_scores_gemma":[0.0007857942,0.99598604,0.0005769257,0.0005611605,0.0004104459,0.0000108511485,0.00007264868,0.00000554655,0.0015906196],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998505,0.00001258216,0.000017205122,0.00003571545,0.00006740325,0.000016563024],"domain_scores_gemma":[0.99972016,0.00008271925,0.000037651556,0.000016097543,0.00009243227,0.00005083719],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00071337575,0.0012945345,0.0013119258,0.0013011241,0.00023833461,0.0009356301,0.0014632612,0.0012461992,0.0022676664],"category_scores_gemma":[0.0005936524,0.00046578833,0.00037768562,0.0016277172,0.0008875098,0.0014556493,0.0007102025,0.0024260841,0.0033786302],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016299673,0.000049855997,0.00015095479,0.0045010294,0.00008154855,0.00017673193,0.000030484793,0.0006231409,0.007247122,0.0060570305,0.07471037,0.9062088],"study_design_scores_gemma":[0.000026574966,0.000032481366,0.0002685464,0.0002719468,0.00003409873,0.00042067718,0.0000127858775,0.000045145916,0.0011928136,0.0014599641,0.9962237,0.000011285273],"about_ca_topic_score_codex":0.001029291,"about_ca_topic_score_gemma":0.00183038,"teacher_disagreement_score":0.0022676664,"about_ca_system_score_codex":0.00091260026,"about_ca_system_score_gemma":0.00093014457,"threshold_uncertainty_score":0.007586062},"labels":[],"label_agreement":null},{"id":"W2169012257","doi":"10.1016/s1470-2045(15)70056-2","title":"Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Medical Association; University of Alberta","funders":"Merck","keywords":"Vorinostat; Tolerability; Medicine; Internal medicine; Placebo; Population; Oncology; Adverse effect; Surgery; Histone deacetylase; Pathology","score_opus":0.03588223247442272,"score_gpt":0.360391855471871,"score_spread":0.3245096229974483,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2169012257","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9808108,0.010811737,0.00061954034,0.0009363683,0.0011113336,0.0019128637,0.0012669165,0.00016747182,0.0023629875],"genre_scores_gemma":[0.98221177,0.0076141725,0.0009533281,0.001164594,0.00044063746,0.0014812958,0.0014961798,0.000026274703,0.0046118097],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99973315,0.00012027749,0.000020396446,0.000052785923,0.000020624713,0.000052774598],"domain_scores_gemma":[0.999613,0.00009920002,0.00008304637,0.00002805413,0.000028714978,0.0001480391],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00096639694,0.0015379603,0.0027533036,0.00032038713,0.00031815574,0.0009527721,0.0008051973,0.0014239087,0.0053411],"category_scores_gemma":[0.0010857333,0.0006381445,0.0021787756,0.00047509602,0.0008772443,0.0010125408,0.00032794333,0.0026893867,0.00078459637],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.96300185,0.003191147,0.00072987657,0.0014673622,0.0018794122,0.00006746033,0.00006359579,0.00040399397,0.0051338393,0.00014450261,0.001291464,0.022625497],"study_design_scores_gemma":[0.94987047,0.04648554,0.0015265951,0.000042608794,0.00057566963,0.000039091265,0.000031002313,0.0002672889,0.00032931508,0.00012378216,0.00069398887,0.000014703483],"about_ca_topic_score_codex":0.0012902815,"about_ca_topic_score_gemma":0.0029604775,"teacher_disagreement_score":0.0053411,"about_ca_system_score_codex":0.00064026116,"about_ca_system_score_gemma":0.000663341,"threshold_uncertainty_score":0.017867804},"labels":[],"label_agreement":null},{"id":"W2169208646","doi":"10.1002/dvdy.20168","title":"Histone deacetylase 1 (HDAC‐1) required for the normal formation of craniofacial cartilage and pectoral fins of the zebrafish","year":2004,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa; Johns Hopkins University","keywords":"Biology; Zebrafish; Histone deacetylase; Cell biology; Mesenchyme; Embryo; Craniofacial; Cartilage; Morpholino; Embryonic stem cell; Anatomy; Histone; Genetics","score_opus":0.010072083946631734,"score_gpt":0.2548634461528069,"score_spread":0.2447913622061752,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2169208646","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9888466,0.003351245,0.0036252984,0.00016411989,0.00004852462,0.000027839526,0.00073081045,0.00016848168,0.0030370655],"genre_scores_gemma":[0.9896248,0.0012295529,0.0025071898,0.000049393042,0.000007236227,0.000025551271,0.00087352016,0.00003310227,0.0056496654],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999335,0.000003022931,0.000003571581,0.000015216358,0.00002503777,0.000019656662],"domain_scores_gemma":[0.99994946,0.0000034349382,0.000019544055,0.0000040027426,0.0000061815563,0.00001737426],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000057913778,0.00039144015,0.00017461441,0.00019457607,0.00023149852,0.00020267154,0.00017251413,0.00019714404,0.0016239857],"category_scores_gemma":[0.00009835324,0.00022405804,0.00017159134,0.00008704411,0.0002663062,0.00013343083,0.00015875878,0.00036911762,0.000526946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000023076766,0.0000031225675,0.00038274724,0.000019088082,0.0000020461782,0.000052763076,0.000006999214,0.000029493825,0.99828315,0.00008048877,0.000051338655,0.0010657342],"study_design_scores_gemma":[0.000041810712,0.0001925238,0.072951294,0.000019926403,0.000039417046,0.00087140134,0.00005141055,0.0008871564,0.915307,0.00019349364,0.009433798,0.00001083327],"about_ca_topic_score_codex":0.0063586608,"about_ca_topic_score_gemma":0.010515081,"teacher_disagreement_score":0.0063586608,"about_ca_system_score_codex":0.0005623614,"about_ca_system_score_gemma":0.0004223637,"threshold_uncertainty_score":0.012643278},"labels":[],"label_agreement":null},{"id":"W2170102261","doi":"10.1158/1535-7163.mct-07-2284","title":"Histone tail modifications and noncanonical functions of histones: perspectives in cancer epigenetics","year":2008,"lang":"en","type":"review","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada); Université de Montréal","funders":"U.S. Food and Drug Administration","keywords":"Histone; Acetylation; Histone deacetylase; Epigenetics; Chromatin; Cancer epigenetics; HDAC11; Biology; Histone deacetylase 5; Histone-modifying enzymes; Cell biology; Chromatin remodeling; Cancer research; Chemistry; Histone methyltransferase; Biochemistry; DNA; Gene","score_opus":0.07793731805207046,"score_gpt":0.39850757749240584,"score_spread":0.32057025944033535,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2170102261","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009514096,0.9978765,0.00022024085,0.00050690403,0.00039718888,0.000002034047,0.000004356936,0.0000065239215,0.0008911694],"genre_scores_gemma":[0.00066420774,0.9977076,0.00022621764,0.0002715971,0.00028885208,0.0000033424412,0.000010288338,0.0000012563368,0.0008266967],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998765,0.000025271043,0.000013372291,0.000025285606,0.000044001292,0.00001563898],"domain_scores_gemma":[0.9997702,0.00009128586,0.000023672093,0.000010894746,0.000066542794,0.000037376885],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006318119,0.00089467445,0.0012223952,0.00124753,0.00035320618,0.0008304881,0.0011583962,0.0014114215,0.0025939657],"category_scores_gemma":[0.00047575202,0.00023739842,0.00036068304,0.0018399574,0.0011541344,0.002336595,0.0006467236,0.002027202,0.001979762],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000119490345,0.00006736933,0.00020525657,0.008073184,0.000063484695,0.00045608132,0.000105516665,0.0007458667,0.0046735653,0.013052116,0.037073504,0.9353646],"study_design_scores_gemma":[0.000021182717,0.00007440236,0.00068056455,0.0009648975,0.00003777175,0.0014804249,0.000070765454,0.000115084076,0.0005928686,0.006624697,0.9893205,0.00001681077],"about_ca_topic_score_codex":0.0010891042,"about_ca_topic_score_gemma":0.0020664895,"teacher_disagreement_score":0.0025939657,"about_ca_system_score_codex":0.001028813,"about_ca_system_score_gemma":0.000807948,"threshold_uncertainty_score":0.008677661},"labels":[],"label_agreement":null},{"id":"W2171820658","doi":"10.1128/ec.00291-12","title":"The Carboxyl Terminus of Rtt109 Functions in Chaperone Control of Histone Acetylation","year":2013,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Toronto Metropolitan University","funders":"National Institute of Environmental Health Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Universities Space Research Association; Banting Research Foundation","keywords":"Histone H3; Acetylation; Histone; Histone octamer; Biology; Histone code; SAP30; Histone H1; Cell biology; Lysine; Biochemistry; Histone methyltransferase; Chromatin; Nucleosome; Amino acid; Gene","score_opus":0.005221526614378155,"score_gpt":0.2492016795278911,"score_spread":0.24398015291351294,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2171820658","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98096484,0.0013982151,0.012110756,0.00022544904,0.00013763823,0.00007618181,0.002634928,0.00027026498,0.0021817903],"genre_scores_gemma":[0.978296,0.0006951232,0.009781792,0.000109714805,0.00002561532,0.0000614958,0.006211356,0.0001483919,0.004670459],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980086,0.000027131291,0.000032220127,0.000054433178,0.00005252946,0.000032894422],"domain_scores_gemma":[0.99974495,0.000028085728,0.000072175426,0.000040887106,0.000028160503,0.00008568135],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012321104,0.0008452957,0.0004438969,0.00019556594,0.00024401795,0.00045384132,0.00053567276,0.0005321524,0.0016313399],"category_scores_gemma":[0.00018113687,0.00020537531,0.0007365156,0.0003229746,0.00028066043,0.00035870957,0.0003941446,0.0008016958,0.0020472112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007131727,0.000012038554,0.00008233726,0.00002649658,0.0000042226584,0.00010568836,0.000009129845,0.00006208544,0.99887174,0.00009992393,0.00003902337,0.0006160378],"study_design_scores_gemma":[0.00002008602,0.00007609009,0.0028584634,0.000009077236,0.000015083671,0.00052951876,0.0000237931,0.0005898638,0.9901162,0.000031415308,0.0057181017,0.000012331426],"about_ca_topic_score_codex":0.0010718758,"about_ca_topic_score_gemma":0.00074355124,"teacher_disagreement_score":0.0016313399,"about_ca_system_score_codex":0.00074852497,"about_ca_system_score_gemma":0.00036110225,"threshold_uncertainty_score":0.0054574013},"labels":[],"label_agreement":null},{"id":"W2189532946","doi":"10.1124/mol.105.014514","title":"Opposite Effects of Histone Deacetylase Inhibitors on Glucocorticoid and Estrogen Signaling in Human Endometrial Ishikawa Cells","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Histone deacetylase; Promoter; Biology; Estrogen receptor; Histone acetyltransferase; Histone; Glucocorticoid receptor; Cancer research; PELP-1; HDAC11; Acetylation; Cell biology; Histone deacetylase inhibitor; Transcription factor; Molecular biology; Nuclear receptor; Glucocorticoid; Gene expression; Endocrinology; Biochemistry; Genetics; Gene; Cancer","score_opus":0.006656953966391741,"score_gpt":0.3204895098814146,"score_spread":0.31383255591502285,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2189532946","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9892993,0.0058373134,0.00084864884,0.00018105362,0.00015179736,0.000023664688,0.0003704821,0.000054339915,0.003233516],"genre_scores_gemma":[0.99211085,0.002431396,0.00079084415,0.0000910398,0.00003631162,0.00003069578,0.00055374554,0.000016195483,0.0039389664],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99970764,0.000052673244,0.000036204554,0.000039128838,0.000069787435,0.000094434814],"domain_scores_gemma":[0.9997938,0.000060692157,0.000020592533,0.000031104475,0.000033447654,0.000060312952],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030244412,0.000320008,0.0006356952,0.00034817134,0.00025882514,0.00043243504,0.00028266857,0.00027464653,0.0019880845],"category_scores_gemma":[0.0002904606,0.00028038627,0.00037594198,0.00031664062,0.00030406084,0.0002741777,0.00020366628,0.0007655716,0.00032465864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018431965,0.000097315016,0.00047948165,0.000089823065,0.00002430619,0.00014857829,0.00006527386,0.000045229062,0.9938291,0.00016778967,0.00008643886,0.0031235314],"study_design_scores_gemma":[0.00015769927,0.0014752744,0.007972833,0.000006095509,0.000082989216,0.0002702213,0.0001632828,0.00027453346,0.9868081,0.00006249204,0.0027173865,0.0000090351905],"about_ca_topic_score_codex":0.0018504602,"about_ca_topic_score_gemma":0.0044120545,"teacher_disagreement_score":0.0019880845,"about_ca_system_score_codex":0.00030322364,"about_ca_system_score_gemma":0.00046229325,"threshold_uncertainty_score":0.0066508055},"labels":[],"label_agreement":null},{"id":"W2194515459","doi":"10.1139/bcb-2015-0096","title":"Transcript level of <i>AKR1C3</i> is down-regulated in gastric cancer","year":2015,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu","keywords":"Cancer; Biology; Genetics; Cancer research; Computational biology; Psychology","score_opus":0.040229003066167425,"score_gpt":0.29133229147712414,"score_spread":0.2511032884109567,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2194515459","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99533033,0.002392181,0.00045765235,0.0000840911,0.000020412672,0.000012248637,0.00082658726,0.00006428952,0.0008121854],"genre_scores_gemma":[0.9949704,0.0009879479,0.0006785777,0.000077564284,0.000012150151,0.000026766953,0.0015930161,0.000018260684,0.0016353481],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998534,0.000011984532,0.0000123927275,0.000040701478,0.000044077296,0.00003743715],"domain_scores_gemma":[0.9997999,0.00003132699,0.00006167205,0.000021341542,0.000048124875,0.000037625305],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010020446,0.00018766729,0.00032905606,0.0004768337,0.0002338313,0.0003876411,0.00014718287,0.0002695894,0.0012500868],"category_scores_gemma":[0.00021666281,0.00012983619,0.00029566916,0.0005770205,0.00026859576,0.00010378719,0.00012737114,0.00034027718,0.0004053067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004919967,0.00001429202,0.009910075,0.000062858504,0.000023031847,0.00019145009,0.000052292147,0.000044655088,0.9867921,0.000022369137,0.00013830948,0.0022565457],"study_design_scores_gemma":[0.000044874203,0.00044960674,0.66412324,0.000016661941,0.00013009497,0.0017075802,0.00037082957,0.00081024115,0.32640848,0.000053998076,0.0058668163,0.00001773612],"about_ca_topic_score_codex":0.0031621982,"about_ca_topic_score_gemma":0.0019701247,"teacher_disagreement_score":0.0031621982,"about_ca_system_score_codex":0.00035606214,"about_ca_system_score_gemma":0.00021525868,"threshold_uncertainty_score":0.006287575},"labels":[],"label_agreement":null},{"id":"W2205484344","doi":"10.1080/19420862.2015.1098795","title":"A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1: a readout for early mitotic cells","year":2015,"lang":"en","type":"article","venue":"mAbs","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Associazione Italiana per la Ricerca sul Cancro; Fondazione Umberto Veronesi; Austrian Science Fund","keywords":"HDAC1; Monoclonal antibody; Prophase; Histone deacetylase; Histone; Mitosis; Phosphorylation; Biology; Cell biology; Serine; Histone deacetylase 5; Chemistry; Molecular biology; Biochemistry; Antibody; Genetics; DNA","score_opus":0.03474904819576767,"score_gpt":0.35044644965662447,"score_spread":0.3156974014608568,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2205484344","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7204063,0.023714906,0.2155952,0.0027253446,0.0015945677,0.0009626301,0.002494265,0.00401398,0.028492916],"genre_scores_gemma":[0.7907397,0.013229274,0.14878343,0.0015264022,0.00074186653,0.0012655271,0.0070197894,0.00032506292,0.036368933],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99938846,0.00006176695,0.00004080861,0.00018716295,0.00014803238,0.00017362997],"domain_scores_gemma":[0.9995503,0.00008490995,0.000063640844,0.00004304763,0.000110930014,0.00014716934],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00049042597,0.0012862612,0.00055707194,0.001187548,0.00044291184,0.0005229683,0.0010906813,0.0015207271,0.006129563],"category_scores_gemma":[0.00033600727,0.0004271167,0.0006404494,0.00050305953,0.00032370794,0.00061106303,0.0005102703,0.0025119747,0.0022366906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006232859,0.000053100874,0.00010668337,0.00007990009,0.000012441833,0.00004264936,0.000010253354,0.000032742686,0.9950512,0.00024107475,0.00042525894,0.0038823932],"study_design_scores_gemma":[0.00010563003,0.0007119034,0.002937274,0.00003776962,0.000100075864,0.0012789058,0.000024262352,0.0016634071,0.9709192,0.00028351948,0.021913754,0.000024191882],"about_ca_topic_score_codex":0.00052598503,"about_ca_topic_score_gemma":0.00085277186,"teacher_disagreement_score":0.006129563,"about_ca_system_score_codex":0.000768406,"about_ca_system_score_gemma":0.00040743055,"threshold_uncertainty_score":0.020505428},"labels":[],"label_agreement":null},{"id":"W2210500005","doi":"10.1038/cddis.2015.376","title":"A minimal ING1b fragment that improves the efficacy of HDAC-based cancer cell killing","year":2015,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Biology; Apoptosis; H3K4me3; Histone deacetylase; Cancer research; Ectopic expression; Cancer cell; Histone; Annexin; Programmed cell death; Cell biology; Molecular biology; Cancer; Cell culture; DNA; Genetics; Gene expression; Promoter; Gene","score_opus":0.021003935502047186,"score_gpt":0.2777429875152362,"score_spread":0.256739052013189,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2210500005","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99300164,0.0021717139,0.0025262407,0.000105543084,0.000051016083,0.00005981239,0.000417303,0.00010988966,0.0015568213],"genre_scores_gemma":[0.990703,0.0012449465,0.0053139976,0.00006515473,0.000012551701,0.000027553358,0.0010705413,0.00004119251,0.0015211152],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998504,0.000017746632,0.00001707973,0.000028961038,0.00004601024,0.00003980476],"domain_scores_gemma":[0.9998869,0.000020892347,0.000027998462,0.000014980095,0.000010614923,0.00003868197],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020100627,0.0005328381,0.0004869194,0.00023668694,0.00013332641,0.00025338095,0.00039782852,0.00036923538,0.001067558],"category_scores_gemma":[0.00012444446,0.00014559258,0.00027040308,0.00019917078,0.00024488755,0.00019163768,0.00017035463,0.0008004759,0.00034736667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015302742,0.00006540174,0.000050863728,0.000023172002,0.000005138882,0.000018122568,0.0000050615367,0.0000907784,0.9986921,0.000040600466,0.00003191305,0.0008238706],"study_design_scores_gemma":[0.000019731175,0.00041641892,0.0005451577,0.0000026960818,0.000013695804,0.00009010312,0.000005184063,0.00025980515,0.9975611,0.000007387268,0.0010762906,0.00000244514],"about_ca_topic_score_codex":0.0006902138,"about_ca_topic_score_gemma":0.0008544181,"teacher_disagreement_score":0.001067558,"about_ca_system_score_codex":0.00042807276,"about_ca_system_score_gemma":0.00020945289,"threshold_uncertainty_score":0.0035713315},"labels":[],"label_agreement":null},{"id":"W2262974530","doi":"10.1186/s13058-016-0676-6","title":"Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Ontario Ministry of Research and Innovation; Ontario Institute for Cancer Research","keywords":"Epirubicin; Anthracycline; Cancer research; Histone deacetylase; Breast cancer; Medicine; Histone; Biology; Cancer; Internal medicine; Genetics; Gene","score_opus":0.025947334573948398,"score_gpt":0.36433089000537183,"score_spread":0.33838355543142346,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2262974530","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99406624,0.0032649143,0.0012110139,0.000060169827,0.000008922276,0.00002328422,0.0006378778,0.000048523067,0.0006791618],"genre_scores_gemma":[0.99490273,0.0014988808,0.00078702485,0.0000430304,0.000006952202,0.00003354309,0.0013581702,0.0000095851765,0.0013601513],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999254,0.000007768447,0.0000064564174,0.000021696373,0.000022319156,0.000016476131],"domain_scores_gemma":[0.9999027,0.000009861872,0.00004442367,0.000006901413,0.0000140387665,0.000021926913],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009590074,0.0002163051,0.00017541477,0.0002928801,0.000106593514,0.00017912325,0.00010500877,0.0001531163,0.0016075707],"category_scores_gemma":[0.00008340563,0.00010551858,0.00013717663,0.00026414086,0.00012997988,0.000082727354,0.000107232416,0.00028322157,0.00034114785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017036918,0.000027692879,0.0043771537,0.000063224084,0.000016050062,0.000061199564,0.0000127907715,0.00003849027,0.993212,0.000020587293,0.000050009356,0.001950344],"study_design_scores_gemma":[0.000045402638,0.00093918643,0.38583103,0.00002021281,0.00010759895,0.0022614035,0.000099079814,0.0008037946,0.60500705,0.000110952904,0.004765433,0.000008839742],"about_ca_topic_score_codex":0.00039409183,"about_ca_topic_score_gemma":0.00075512746,"teacher_disagreement_score":0.0016075707,"about_ca_system_score_codex":0.00020787299,"about_ca_system_score_gemma":0.00011303555,"threshold_uncertainty_score":0.005377829},"labels":[],"label_agreement":null},{"id":"W2273359029","doi":"10.1093/bfgp/elv045","title":"Building a KATalogue of acetyllysine targeting and function","year":2015,"lang":"en","type":"review","venue":"Briefings in Functional Genomics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Acetylation; Acetyltransferases; Lysine; Biology; Histone; Context (archaeology); Computational biology; Saccharomyces cerevisiae; Posttranslational modification; Histone Acetyltransferases; Biochemistry; Scope (computer science); Function (biology); Gene; Enzyme; Genetics; Computer science; Amino acid","score_opus":0.03982214581339268,"score_gpt":0.3132360293550967,"score_spread":0.27341388354170404,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2273359029","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0002212738,0.9943592,0.0008463634,0.0012154111,0.0005785176,0.00000709748,0.000048466456,0.00002590808,0.002697737],"genre_scores_gemma":[0.0017010736,0.994276,0.0007683699,0.0008841678,0.0003009755,0.000012470054,0.00007622024,0.0000072676025,0.0019735114],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997843,0.000038712176,0.000028276012,0.00004956087,0.000071750634,0.000027440441],"domain_scores_gemma":[0.99968684,0.00015005472,0.00003091107,0.000018678733,0.00007594662,0.000037634614],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00082967774,0.0008020851,0.001106516,0.0018626084,0.00041154414,0.0016335625,0.0011713766,0.0017115208,0.004443251],"category_scores_gemma":[0.001013306,0.0004410204,0.0004783369,0.001472022,0.0012355507,0.0036374552,0.0011577312,0.0030901618,0.0041829688],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012099306,0.000060629347,0.00029873278,0.013024112,0.000092071954,0.00040591153,0.00018316807,0.0006769981,0.005678687,0.056795653,0.048755586,0.87390745],"study_design_scores_gemma":[0.0000057981256,0.000037600046,0.00023787112,0.000996401,0.000024942507,0.00044673632,0.00004114211,0.00006709898,0.0006508144,0.0076422403,0.9898363,0.000012994576],"about_ca_topic_score_codex":0.0009542493,"about_ca_topic_score_gemma":0.0013412904,"teacher_disagreement_score":0.004443251,"about_ca_system_score_codex":0.0009990213,"about_ca_system_score_gemma":0.0013351135,"threshold_uncertainty_score":0.014864206},"labels":[],"label_agreement":null},{"id":"W2273979249","doi":"10.1155/2016/8627384","title":"Age‐Dependent Demethylation of <i>Sod2</i> Promoter in the Mouse Femoral Artery","year":2016,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Novartis (Canada); Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"SOD2; Femoral artery; Demethylation; Biology; Andrology; Medicine; Internal medicine; Genetics; Gene; Superoxide dismutase; Gene expression; DNA methylation","score_opus":0.02624806850648436,"score_gpt":0.282729778897169,"score_spread":0.2564817103906846,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2273979249","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99510056,0.00092952925,0.0028854385,0.00005736757,0.000022532427,0.000012645129,0.0003294385,0.000051999028,0.0006105491],"genre_scores_gemma":[0.99168605,0.0008514108,0.002252393,0.00008144109,0.000021518252,0.000056964887,0.00058657274,0.000028143275,0.0044354154],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998797,0.000014431222,0.0000085292695,0.00005097445,0.000018247123,0.000028099106],"domain_scores_gemma":[0.99987745,0.0000103429375,0.000054223878,0.000013588354,0.000016660138,0.000027738963],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018974998,0.0002345306,0.00019309511,0.00023801328,0.00009876931,0.00017985643,0.00014105663,0.00021132508,0.0009480259],"category_scores_gemma":[0.00009762273,0.00024307636,0.00027398617,0.000108518136,0.0001845291,0.00018525754,0.00012696069,0.00046673993,0.00024327669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011107083,0.000011028001,0.0003533323,0.0000070729393,0.000002303327,0.00001095284,0.000012834461,0.0000070820042,0.9989882,0.000022252352,0.000009224878,0.00046469996],"study_design_scores_gemma":[0.000020522366,0.0004892205,0.037307356,0.0000053679905,0.00003057631,0.00017468783,0.000035426274,0.00030426288,0.96042824,0.000051195377,0.0011471459,0.000006041441],"about_ca_topic_score_codex":0.00074739597,"about_ca_topic_score_gemma":0.0013926008,"teacher_disagreement_score":0.0009480259,"about_ca_system_score_codex":0.00014818905,"about_ca_system_score_gemma":0.00012050833,"threshold_uncertainty_score":0.003171444},"labels":[],"label_agreement":null},{"id":"W2278797968","doi":"10.1200/jco.2005.23.16_suppl.9039","title":"Effect of depsipeptide (NSC 630176), a histone deacetylase inhibitor, on human synovial sarcoma <i>in vitro</i>","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Synovial sarcoma; Cancer research; Histone deacetylase inhibitor; Apoptosis; Depsipeptide; Molecular biology; Cell culture; Cytotoxic T cell; MTT assay; Medicine; Histone deacetylase; Sarcoma; In vitro; Histone; Biology; Pathology; Biochemistry","score_opus":0.048962547608463594,"score_gpt":0.4719109771773958,"score_spread":0.4229484295689322,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2278797968","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.990531,0.004607881,0.00062679464,0.00009089605,0.000059334412,0.0000681999,0.0009470217,0.00005033572,0.0030185797],"genre_scores_gemma":[0.99151003,0.0035336385,0.0012394991,0.00007544318,0.000025514395,0.00006202055,0.0016394837,0.000012466284,0.0019019404],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989676,0.000027488268,0.000017190467,0.000015987653,0.000020088955,0.00002247853],"domain_scores_gemma":[0.99988484,0.0000338857,0.000020950129,0.000012504036,0.000021776832,0.000025974674],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513672,0.00040555175,0.00041465551,0.000198575,0.0001413019,0.00017757574,0.00016574915,0.00019638946,0.0010982832],"category_scores_gemma":[0.00011215321,0.000106209984,0.00030636427,0.00020155862,0.00012349899,0.0001108478,0.00012030488,0.0003726965,0.000500344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013533256,0.00031288,0.00049830956,0.00022755493,0.000029581819,0.00018180608,0.000071398776,0.00040014507,0.99058414,0.000055245826,0.0003484173,0.0059372378],"study_design_scores_gemma":[0.00012762769,0.006679686,0.0055247853,0.000017966226,0.00006629028,0.00037730436,0.00006660878,0.0010638974,0.9835865,0.000022096685,0.0024586704,0.000008641278],"about_ca_topic_score_codex":0.0020858452,"about_ca_topic_score_gemma":0.0028789816,"teacher_disagreement_score":0.0020858452,"about_ca_system_score_codex":0.00019165211,"about_ca_system_score_gemma":0.00024079182,"threshold_uncertainty_score":0.00414747},"labels":[],"label_agreement":null},{"id":"W2279265373","doi":"10.1182/blood.v122.21.5137.5137","title":"Resistance To Vorinostat In Hematological Malignancies May Involve Cytoprotective UPR and Correlates With Increased Sensitivity To Bortezomib-Induced Cell Death","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Vorinostat; Bortezomib; Histone deacetylase inhibitor; Proteasome inhibitor; Cancer research; Autophagy; Histone deacetylase; Biology; Proteasome; Pharmacology; Medicine; Immunology; Histone; Apoptosis; Multiple myeloma; Cell biology","score_opus":0.009800577781426952,"score_gpt":0.23043192929206033,"score_spread":0.22063135151063337,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2279265373","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9960765,0.001219384,0.0010252049,0.00008552129,0.000012026019,0.000036812147,0.00043644692,0.00007847822,0.0010296494],"genre_scores_gemma":[0.99699855,0.00038425488,0.0009183334,0.000043975513,0.00000805752,0.000031953135,0.0007054973,0.000009676975,0.00089965056],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980956,0.000038480775,0.000029173381,0.00003429141,0.0000551755,0.00003325803],"domain_scores_gemma":[0.9998349,0.000046037392,0.000047988608,0.000024929235,0.000018756047,0.000027327598],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017206615,0.0002514988,0.00031235992,0.00036708981,0.00012646952,0.00029017107,0.0001075059,0.00029363643,0.0018465829],"category_scores_gemma":[0.00013690522,0.00011784714,0.00020351446,0.0002862989,0.0001641269,0.00014109537,0.00011600769,0.00048889755,0.0003506473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014871969,0.00007041359,0.0025813533,0.000021592297,0.00001067859,0.000103894185,0.00001475769,0.00009269906,0.9949419,0.0000384156,0.0000817624,0.0018937768],"study_design_scores_gemma":[0.00003208885,0.0015625826,0.072943345,0.0000074163054,0.000037919497,0.0016562217,0.00006130677,0.0013468628,0.92030805,0.000065747234,0.0019714502,0.000007003346],"about_ca_topic_score_codex":0.00031252045,"about_ca_topic_score_gemma":0.00041348455,"teacher_disagreement_score":0.0018465829,"about_ca_system_score_codex":0.00020807705,"about_ca_system_score_gemma":0.00008307138,"threshold_uncertainty_score":0.0061774254},"labels":[],"label_agreement":null},{"id":"W2282283062","doi":"10.1093/toxsci/kfv174","title":"The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"McGill University; Fonds de Recherche du Québec - Santé; University of Cincinnati; Canadian Institutes of Health Research; University of Connecticut","keywords":"Histone deacetylase; Chondrogenesis; Chondrocyte; Cell biology; Biology; Chemistry; Cellular differentiation; Cartilage; Histone; Molecular biology; Biochemistry; Anatomy; Mesenchymal stem cell; Gene","score_opus":0.04031906342290938,"score_gpt":0.30629931543913186,"score_spread":0.2659802520162225,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2282283062","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9906336,0.0047470382,0.0010272679,0.00012101838,0.00010694255,0.000041849882,0.00055119576,0.00007760688,0.0026934089],"genre_scores_gemma":[0.9905432,0.0036346125,0.0015317899,0.00011772404,0.000025106761,0.00004910591,0.0006818295,0.000027855422,0.003388778],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980253,0.000032568907,0.000021062146,0.00004373256,0.000051636303,0.000048427526],"domain_scores_gemma":[0.99983597,0.000033204145,0.000049898503,0.000016536458,0.00002126531,0.00004314416],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017043376,0.0004545544,0.00031280037,0.00021677399,0.00013737546,0.00020282019,0.0002196673,0.00023915338,0.0012082977],"category_scores_gemma":[0.00015412291,0.00013490372,0.00036920788,0.00011687687,0.0001996564,0.00015702935,0.00013305766,0.00069757324,0.00024093282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030904968,0.000069036345,0.00023706873,0.00006556289,0.000012248964,0.000037557074,0.000012700009,0.00008664839,0.9969747,0.00004453663,0.00007494653,0.0020760482],"study_design_scores_gemma":[0.000021693142,0.0011115446,0.0047784946,0.000007093821,0.00002962868,0.000086889006,0.00002448079,0.0003370169,0.99190825,0.000017108789,0.0016730773,0.0000047452745],"about_ca_topic_score_codex":0.0010337308,"about_ca_topic_score_gemma":0.002915208,"teacher_disagreement_score":0.0012082977,"about_ca_system_score_codex":0.0002697668,"about_ca_system_score_gemma":0.00026694982,"threshold_uncertainty_score":0.004042208},"labels":[],"label_agreement":null},{"id":"W2282391237","doi":"10.1200/jco.2007.25.18_suppl.3576","title":"A phase I study of vorinostat (VOR) in combination with capecitabine (CAP) in patients (pts) with advanced solid tumors","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nausea; Capecitabine; Tolerability; Vomiting; Gastroenterology; Internal medicine; Vorinostat; Toxicity; Pharmacology; Adverse effect; Colorectal cancer; Cancer; Histone deacetylase","score_opus":0.03325700206045453,"score_gpt":0.4390823767019945,"score_spread":0.40582537464154,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2282391237","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9947589,0.001361216,0.000381388,0.00028200354,0.0000741739,0.001515667,0.00042988945,0.00004542902,0.0011514537],"genre_scores_gemma":[0.99227566,0.0015249624,0.0013502083,0.00043730962,0.00014203256,0.0012773529,0.0012386735,0.000016286698,0.0017375386],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.9997298,0.0001094917,0.000015195772,0.00005496235,0.00002971215,0.000060760307],"domain_scores_gemma":[0.99951136,0.00007871595,0.00008353769,0.000033326527,0.000029999179,0.00026302363],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008730794,0.0012484465,0.0017599788,0.00044064323,0.00046393878,0.0008504202,0.00057835795,0.0007846289,0.0026128476],"category_scores_gemma":[0.00070699863,0.00054785906,0.00095273805,0.0005220586,0.0008498159,0.0006299765,0.00028149222,0.0025513626,0.00066779606],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.5998494,0.13294479,0.013099118,0.0012080643,0.0012182622,0.001344419,0.00072553323,0.004455615,0.118889384,0.00040163205,0.0049151974,0.12094857],"study_design_scores_gemma":[0.23578176,0.7417494,0.012609124,0.000029620394,0.00029483723,0.0005305476,0.00007704341,0.0010804833,0.004977887,0.000109514025,0.0027369058,0.000022892535],"about_ca_topic_score_codex":0.0011926668,"about_ca_topic_score_gemma":0.002458227,"teacher_disagreement_score":0.0026128476,"about_ca_system_score_codex":0.0010731438,"about_ca_system_score_gemma":0.0017567439,"threshold_uncertainty_score":0.008740902},"labels":[],"label_agreement":null},{"id":"W2287508718","doi":"10.1200/jco.2009.27.15_suppl.3528","title":"Phase I study of intravenous decitabine in combination with oral vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas (NHL)","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Decitabine; Neutropenia; Internal medicine; Gastroenterology; Febrile neutropenia; Pharmacokinetics; Adverse effect; Leukopenia; Tolerability; Oncology; Toxicity","score_opus":0.021230536163726742,"score_gpt":0.40559108074494665,"score_spread":0.38436054458121993,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2287508718","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9953738,0.0009288052,0.00042776184,0.00016916204,0.000048211037,0.0016880741,0.00042157323,0.000036759873,0.0009059929],"genre_scores_gemma":[0.9919733,0.0011451322,0.0016447563,0.00028791395,0.00011071822,0.0021445428,0.0013705179,0.000016574908,0.0013065997],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99971753,0.00012771723,0.000015193122,0.000048239177,0.000027076636,0.00006425524],"domain_scores_gemma":[0.99956065,0.000071770235,0.0000752401,0.000045097826,0.000023839997,0.00022341582],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007258692,0.0010585897,0.0020481679,0.00045421676,0.000367704,0.0008093929,0.00069323176,0.0006549291,0.0023967912],"category_scores_gemma":[0.00060339243,0.00055916596,0.0007544639,0.0004836556,0.0006866192,0.0004891449,0.00035895215,0.001987188,0.0006360011],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.550012,0.17241748,0.015626878,0.0010311932,0.0012507931,0.0005906624,0.00055624143,0.006302818,0.10021501,0.00045051082,0.0030250726,0.14852129],"study_design_scores_gemma":[0.25354272,0.7224586,0.012196401,0.000031832813,0.00037273535,0.00031861835,0.000072093804,0.0015711049,0.006462593,0.00014208011,0.0028095,0.000021578655],"about_ca_topic_score_codex":0.0008223174,"about_ca_topic_score_gemma":0.0015138282,"teacher_disagreement_score":0.0023967912,"about_ca_system_score_codex":0.00074415625,"about_ca_system_score_gemma":0.0018228977,"threshold_uncertainty_score":0.008018076},"labels":[],"label_agreement":null},{"id":"W2289522086","doi":"10.71781/29709","title":"Rôle de l’acétylation/déacétylation des histones dans la régulation de l’expression des gènes de la COX-2, iNOS et mPGES-1 dans les tissus articulaires","year":2012,"lang":"fr","type":"dissertation","venue":"Papyrus : Institutional Repository (Université de Montréal)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"University of California, Los Angeles; Université de Montréal; Morehouse School of Medicine; Canadian Institutes of Health Research; Moffitt Cancer Center; McGill University","keywords":"Molecular biology; Chemistry; Biology","score_opus":0.007049309645863412,"score_gpt":0.2223141833245985,"score_spread":0.2152648736787351,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2289522086","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8840848,0.093851306,0.012293929,0.0007028645,0.0003813848,0.000068728,0.00078500056,0.000091872236,0.007740064],"genre_scores_gemma":[0.96955365,0.017118959,0.0027945638,0.00017352734,0.00010583676,0.000039167524,0.000465577,0.000015200613,0.009733478],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999729,0.000044030392,0.000018886916,0.00008707988,0.00007379113,0.000047356436],"domain_scores_gemma":[0.9997894,0.000027865426,0.00006706495,0.000016039383,0.00006274249,0.000036910762],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034396615,0.00025455825,0.00023065577,0.0002495659,0.00026495455,0.00053596776,0.00020003805,0.00031204263,0.0012745636],"category_scores_gemma":[0.0002335283,0.00018796923,0.00030088014,0.0001874064,0.0004846984,0.00030109595,0.00020022965,0.00036137638,0.00039636428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042822777,0.00003811093,0.0046879817,0.000373643,0.000050555558,0.00017976311,0.00018067178,0.00017419568,0.98080355,0.0005943772,0.00012615678,0.0123627],"study_design_scores_gemma":[0.000071270224,0.0012280515,0.29037413,0.000142365,0.00017375003,0.0014134361,0.00070165313,0.0018967089,0.6729454,0.0012223157,0.02976269,0.000068335874],"about_ca_topic_score_codex":0.0019857811,"about_ca_topic_score_gemma":0.0023968185,"teacher_disagreement_score":0.0019857811,"about_ca_system_score_codex":0.0003126143,"about_ca_system_score_gemma":0.00037554614,"threshold_uncertainty_score":0.0042638183},"labels":[],"label_agreement":null},{"id":"W2293871643","doi":"10.1074/jbc.m115.692707","title":"Retinoid X Receptor-selective Signaling in the Regulation of Akt/Protein Kinase B Isoform-specific Expression","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Myogenesis; Bexarotene; Protein kinase B; Biology; Retinoid X receptor; Cellular differentiation; PI3K/AKT/mTOR pathway; Cell biology; Signal transduction; Gene isoform; Cancer research; Myocyte; Nuclear receptor; Transcription factor; Genetics; Gene","score_opus":0.035421088174092855,"score_gpt":0.28173484416626343,"score_spread":0.2463137559921706,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2293871643","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9788848,0.009010742,0.005210226,0.00037796327,0.0001184803,0.00008332029,0.00048152992,0.000098037934,0.0057349172],"genre_scores_gemma":[0.9793936,0.0075381463,0.0053190556,0.00015290739,0.000024491748,0.000056184952,0.0003510602,0.000017649476,0.0071468493],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998599,0.000032547738,0.000013608398,0.000033577453,0.000029292585,0.00003096021],"domain_scores_gemma":[0.9999572,0.000005909716,0.000013139544,0.0000063553466,0.0000066200455,0.000010734558],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022011723,0.00026666216,0.00016224556,0.00030901138,0.00025389966,0.00037477224,0.0001267907,0.00023348264,0.0016226155],"category_scores_gemma":[0.00008903516,0.00014507954,0.00030124752,0.00017035594,0.00024720316,0.00030815997,0.00013834059,0.00048812834,0.0005585284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024665386,0.000044409655,0.00021628528,0.000058300673,0.000004848468,0.000058201953,0.000021147569,0.00007815485,0.99672395,0.00038551484,0.00004213071,0.0021204248],"study_design_scores_gemma":[0.00007563093,0.0004425062,0.015255003,0.000024041728,0.000036539677,0.00039285616,0.00010787731,0.0012878494,0.9728224,0.00030210134,0.009240903,0.000012379516],"about_ca_topic_score_codex":0.00085257075,"about_ca_topic_score_gemma":0.0013461328,"teacher_disagreement_score":0.0016226155,"about_ca_system_score_codex":0.0002513787,"about_ca_system_score_gemma":0.000389568,"threshold_uncertainty_score":0.005428195},"labels":[],"label_agreement":null},{"id":"W2300908044","doi":"10.1016/j.ccell.2016.02.011","title":"HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC- Driven Medulloblastoma","year":2016,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; CureSearch for Children's Cancer; Alex's Lemonade Stand Foundation for Childhood Cancer; California Institute for Regenerative Medicine","keywords":"Cancer research; Histone deacetylase; Medulloblastoma; In vivo; FOXO1; In vitro; PI3K/AKT/mTOR pathway; Suppressor; Pharmacology; Biology; Histone; Medicine; Cancer; Signal transduction; Protein kinase B; Internal medicine; Gene; Cell biology; Biochemistry","score_opus":0.006459295289529126,"score_gpt":0.2584180493650198,"score_spread":0.2519587540754907,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2300908044","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9901361,0.0023931763,0.0013819016,0.00026082475,0.00009169232,0.000051882947,0.0008468407,0.00021464437,0.00462299],"genre_scores_gemma":[0.9946861,0.0009878469,0.0008425053,0.000043819487,0.000014354812,0.00003813521,0.0007104853,0.000030039162,0.0026466826],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997534,0.000032402553,0.000020485635,0.000025294745,0.000080378246,0.000088067434],"domain_scores_gemma":[0.999877,0.000027688919,0.000022513119,0.000020167414,0.000009723433,0.000042868218],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024021787,0.0004990277,0.00051520823,0.00059566647,0.00029417835,0.0004921298,0.000474059,0.0002406151,0.0019271601],"category_scores_gemma":[0.00019953458,0.0002632519,0.0004102945,0.00041679142,0.0002709507,0.000245809,0.00030633068,0.0010390378,0.00052252854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00093827496,0.000320615,0.000847043,0.000048191396,0.000038974402,0.0001141359,0.000023384406,0.00042216113,0.9895923,0.0005032292,0.00058602216,0.0065656626],"study_design_scores_gemma":[0.0001428871,0.0008445069,0.007145003,0.000004830025,0.000058029796,0.0003570073,0.00005046916,0.002327236,0.9832756,0.000095588126,0.00569153,0.000007326491],"about_ca_topic_score_codex":0.0029088103,"about_ca_topic_score_gemma":0.010185774,"teacher_disagreement_score":0.0029088103,"about_ca_system_score_codex":0.000869471,"about_ca_system_score_gemma":0.0006314062,"threshold_uncertainty_score":0.006447017},"labels":[],"label_agreement":null},{"id":"W2313073532","doi":"10.1158/0008-5472.sabcs10-p4-04-06","title":"Abstract P4-04-06: Histone H2A Inhibits Breast Cancer Stem Cell Growth","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Histone deacetylase; HDAC11; Histone deacetylase 5; Histone; Cancer research; Biology; Acetylation; Histone H2A; Cancer epigenetics; Epigenetics; Histone deacetylase 2; Cell biology; Histone methyltransferase; Genetics; Gene","score_opus":0.027554949101061633,"score_gpt":0.367503215345437,"score_spread":0.33994826624437535,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2313073532","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98630315,0.0039689844,0.0013604317,0.0004383692,0.00027545408,0.0002243258,0.0015110568,0.00026140097,0.005656879],"genre_scores_gemma":[0.97957236,0.0022525669,0.0029021427,0.00025404338,0.00014591448,0.00022637058,0.0029816232,0.00004463929,0.011620306],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998901,0.000018747854,0.0000114204895,0.0000149596135,0.000030952287,0.000033787583],"domain_scores_gemma":[0.9998653,0.000032439606,0.000022961722,0.000014770672,0.000015091214,0.00004936294],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021711444,0.00050700404,0.00039545092,0.00045279856,0.00020377037,0.00025908017,0.0004954167,0.0005222457,0.006517678],"category_scores_gemma":[0.0001236727,0.00012043859,0.00033372678,0.0002582614,0.00027820704,0.00013520081,0.0001755215,0.0011247682,0.0011652485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021782287,0.00091143,0.0002220393,0.0002304191,0.000034320547,0.00008949024,0.000015825008,0.00015685729,0.98732066,0.00014462516,0.00061923295,0.008076807],"study_design_scores_gemma":[0.00065627904,0.0072563463,0.0027665512,0.000014660044,0.00005434021,0.00019252236,0.000021501162,0.0006863402,0.9826005,0.00005062843,0.005695001,0.0000052467826],"about_ca_topic_score_codex":0.00076941284,"about_ca_topic_score_gemma":0.0008478857,"teacher_disagreement_score":0.006517678,"about_ca_system_score_codex":0.00023444678,"about_ca_system_score_gemma":0.00050916936,"threshold_uncertainty_score":0.021803796},"labels":[],"label_agreement":null},{"id":"W2317790835","doi":"10.1038/sj.onc.1205787","title":"The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Trichostatin A; Sodium butyrate; Biology; Histone deacetylase; Promoter; HDAC4; Cancer research; HDAC11; HDAC10; Histone deacetylase 2; Histone deacetylase inhibitor; Proto-oncogene tyrosine-protein kinase Src; Histone deacetylase 5; Molecular biology; Histone; Cell biology; Gene expression; Signal transduction; Biochemistry; Cell culture; Genetics; Gene","score_opus":0.015220922221604706,"score_gpt":0.2861961904230984,"score_spread":0.2709752682014937,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2317790835","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97965723,0.007094122,0.006427806,0.0001560936,0.000074583484,0.000030642263,0.00071467925,0.00019858129,0.0056462237],"genre_scores_gemma":[0.99150956,0.0016190979,0.0013410508,0.000038071907,0.000030347403,0.000023563305,0.0016197814,0.000049532246,0.0037689714],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973744,0.000021365031,0.000015560669,0.00005040936,0.00007209117,0.000103055194],"domain_scores_gemma":[0.99969184,0.000068566216,0.000085324216,0.000038521554,0.00003991137,0.00007585261],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016437013,0.00040627943,0.0002748019,0.00039503723,0.00020106051,0.00044380763,0.00020121202,0.00014224144,0.0017181131],"category_scores_gemma":[0.00031550307,0.0002433718,0.00030171432,0.0002730591,0.0003163805,0.00016456773,0.0003293115,0.00044594772,0.0005887412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017544624,0.000018071116,0.00042467166,0.000019786214,0.000004419206,0.000052748444,0.000017363533,0.00003390904,0.9969523,0.00036266338,0.00005941825,0.0018793354],"study_design_scores_gemma":[0.000034880864,0.00017888517,0.014940445,0.0000070585943,0.000026153104,0.0007565534,0.000049079976,0.00063783716,0.97930187,0.00021124209,0.0038500286,0.000005855649],"about_ca_topic_score_codex":0.00095940585,"about_ca_topic_score_gemma":0.0027040152,"teacher_disagreement_score":0.0017181131,"about_ca_system_score_codex":0.00044744424,"about_ca_system_score_gemma":0.00034284554,"threshold_uncertainty_score":0.0057476163},"labels":[],"label_agreement":null},{"id":"W2323767515","doi":"10.1158/1535-7163.targ-09-a188","title":"Abstract A188: Proapoptotic <i>versus</i> prosurvival function of the MAP kinase p38 induced by HDAC inhibitor in hematological malignant cells","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Vorinostat; Histone deacetylase inhibitor; Sodium butyrate; DNA damage; Apoptosis; p38 mitogen-activated protein kinases; Cell cycle; Biology; Cell cycle checkpoint; Histone deacetylase; Cancer research; Cell biology; Kinase; Chemistry; Histone; Cell culture; Protein kinase A; Biochemistry; DNA","score_opus":0.022723297742067893,"score_gpt":0.2864238494424917,"score_spread":0.26370055170042384,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2323767515","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9907865,0.0032108058,0.0013626958,0.00019524062,0.00009652704,0.000039174305,0.00078484387,0.00013554975,0.0033887555],"genre_scores_gemma":[0.9944741,0.0010496373,0.00089230697,0.000068551235,0.000036910464,0.00004188459,0.00079674425,0.0000149325015,0.0026249783],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999443,0.000008724758,0.00000520158,0.000009421116,0.000014699943,0.000017585244],"domain_scores_gemma":[0.9999647,0.000007055373,0.000009094622,0.0000037150846,0.0000042803736,0.000011196204],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000056952485,0.00028099216,0.00019516583,0.00015423332,0.00010856254,0.00015059397,0.00010871161,0.00013346608,0.003772726],"category_scores_gemma":[0.000055202396,0.000059996135,0.00017674059,0.000115269235,0.00012060224,0.00013827729,0.00006859148,0.00038702777,0.0004575614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042630607,0.00005537122,0.00015755632,0.000057091365,0.0000053525505,0.000086996755,0.0000089282075,0.000031130603,0.9973278,0.00008735441,0.00013345755,0.0016225993],"study_design_scores_gemma":[0.00005230108,0.0009112736,0.0035932725,0.0000050199237,0.000014519717,0.00029132862,0.000022584607,0.00031835175,0.99231476,0.00005544245,0.0024190415,0.0000021899011],"about_ca_topic_score_codex":0.00027929558,"about_ca_topic_score_gemma":0.00022731043,"teacher_disagreement_score":0.003772726,"about_ca_system_score_codex":0.00013396691,"about_ca_system_score_gemma":0.00010977288,"threshold_uncertainty_score":0.012621045},"labels":[],"label_agreement":null},{"id":"W2328198526","doi":"10.1016/j.pharmthera.2016.03.003","title":"Emerging therapeutic targets in metastatic progression: A focus on breast cancer","year":2016,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; Stem Cell Network; Howard Hughes Medical Institute; Brewster Foundation; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Breast cancer; Metastasis; Metastatic breast cancer; Medicine; Cancer; Stromal cell; Oncology; Cancer research; Internal medicine","score_opus":0.0551328506508307,"score_gpt":0.4462391177077469,"score_spread":0.3911062670569162,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2328198526","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00013774954,0.9981882,0.00023461926,0.00034517748,0.0002526453,0.000005344115,0.00002365969,0.000012005469,0.00080058555],"genre_scores_gemma":[0.0010384942,0.9974572,0.0002774196,0.0003056669,0.000218577,0.0000073767133,0.000033600267,0.0000025395955,0.00065908494],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99986196,0.000022451997,0.000017125858,0.00002965394,0.00004416701,0.000024588435],"domain_scores_gemma":[0.9997489,0.0001073071,0.000038763745,0.0000074013656,0.000064615386,0.00003305586],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00059100974,0.000979243,0.0015965422,0.0015443962,0.00024220187,0.001002215,0.000716834,0.00094649615,0.0039888876],"category_scores_gemma":[0.00067670457,0.00027308436,0.00050945365,0.0017112512,0.00049904245,0.0011955138,0.0007013124,0.0025549522,0.0016420261],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019083015,0.00012422755,0.0001746904,0.012392452,0.0000937514,0.00018413649,0.000037656686,0.0005194784,0.003820445,0.0041108886,0.036259186,0.94209224],"study_design_scores_gemma":[0.00008317633,0.00028864562,0.0007904427,0.0029976482,0.00026236655,0.0010787058,0.00006460782,0.00032140277,0.0013064375,0.0031982183,0.9895812,0.00002694629],"about_ca_topic_score_codex":0.0006332983,"about_ca_topic_score_gemma":0.0025666677,"teacher_disagreement_score":0.0039888876,"about_ca_system_score_codex":0.0005688811,"about_ca_system_score_gemma":0.0009867145,"threshold_uncertainty_score":0.013344169},"labels":[],"label_agreement":null},{"id":"W2342006085","doi":"10.1093/neuonc/nov205.10","title":"ATNT-10DOES VALPROIC ACID IMPROVE SURVIVAL IN GLIOBLASTOMA? A META-ANALYSIS OF RANDOMIZED TRIALS IN NEWLY DIAGNOSED GLIOBLASTOMA","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Temozolomide; Medicine; Internal medicine; Hazard ratio; Oncology; Valproic Acid; Progression-free survival; Chemoradiotherapy; Post-hoc analysis; Confidence interval; Cancer; Epilepsy; Overall survival; Chemotherapy; Psychiatry","score_opus":0.06600521054757182,"score_gpt":0.36325196459402653,"score_spread":0.29724675404645473,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2342006085","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.14247963,0.8513087,0.0017085824,0.0010593267,0.0009776291,0.00028315018,0.0010735564,0.00009565332,0.001013717],"genre_scores_gemma":[0.9189902,0.07599864,0.0014187999,0.0011707115,0.0005472364,0.00029775448,0.0009532413,0.00005437415,0.0005689988],"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","domain_scores_codex":[0.988555,0.007863203,0.0015848117,0.0011323941,0.0005357221,0.00032889226],"domain_scores_gemma":[0.98719203,0.00882922,0.002049166,0.0009791625,0.0005222145,0.00042828242],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.015066739,0.0019253687,0.009028339,0.0016326163,0.0004052412,0.002681826,0.0012479394,0.0018833731,0.002421637],"category_scores_gemma":[0.01680831,0.0010983862,0.031594764,0.002229294,0.0006885421,0.0013847821,0.0010103662,0.0024410158,0.0003048306],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.041876506,0.000053280215,0.011207612,0.019577248,0.916182,0.000077842,0.000039172857,0.00065926753,0.00047819255,0.000117568525,0.00050333736,0.009227918],"study_design_scores_gemma":[0.008170596,0.0011558392,0.011740887,0.0011767392,0.97523075,0.00006572964,0.000042624135,0.0005854585,0.00021301887,0.00035900532,0.0012361546,0.000023194349],"about_ca_topic_score_codex":0.003884735,"about_ca_topic_score_gemma":0.008642789,"teacher_disagreement_score":0.015066739,"about_ca_system_score_codex":0.0012961878,"about_ca_system_score_gemma":0.0009728497,"threshold_uncertainty_score":0.079681516},"labels":[],"label_agreement":null},{"id":"W2347124890","doi":"10.1042/cs20160084","title":"The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease","year":2016,"lang":"en","type":"review","venue":"Clinical Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"HDAC6; Disease; Malignancy; Neurodegeneration; Biology; Histone deacetylase; Proteasome; Cancer research; Medicine; Histone; Cell biology; Genetics; Pathology","score_opus":0.07270271671695265,"score_gpt":0.4596861647569606,"score_spread":0.38698344804000795,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2347124890","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0016725531,0.96932673,0.0016810494,0.018722668,0.0027005551,0.000023094377,0.00007892964,0.000080959595,0.005713325],"genre_scores_gemma":[0.012888519,0.95974344,0.0031522762,0.010043209,0.0046544317,0.000046554575,0.00017449602,0.000030187883,0.009266831],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997594,0.00006591565,0.000023603601,0.000041666306,0.00007132566,0.000038193968],"domain_scores_gemma":[0.99966323,0.00011504712,0.000046773886,0.000015869517,0.00008461833,0.000074507036],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00088962936,0.00061105634,0.000736063,0.0007843011,0.00037478597,0.0011491637,0.00048495102,0.0016320677,0.004358153],"category_scores_gemma":[0.00076079456,0.00017951154,0.0004653874,0.0005497083,0.00082921545,0.001635951,0.0007038192,0.0039558015,0.002328025],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00070474914,0.00029119698,0.0007466592,0.0041513457,0.00010675512,0.00098382,0.00022393366,0.0005365344,0.024937656,0.031965256,0.124423146,0.810929],"study_design_scores_gemma":[0.00010127447,0.0005610844,0.00073208805,0.0006019592,0.000056278674,0.0016386387,0.00006961568,0.00015040257,0.0024337997,0.009062239,0.98456925,0.000023395336],"about_ca_topic_score_codex":0.00033157185,"about_ca_topic_score_gemma":0.0013189442,"teacher_disagreement_score":0.004358153,"about_ca_system_score_codex":0.000718701,"about_ca_system_score_gemma":0.00065026316,"threshold_uncertainty_score":0.014579415},"labels":[],"label_agreement":null},{"id":"W235826207","doi":"10.1007/s10637-015-0252-4","title":"A phase II study of the HDAC inhibitor SB939 in patients with castration resistant prostate cancer: NCIC clinical trials group study IND195","year":2015,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University; Princess Margaret Cancer Centre; Queen Elizabeth II Health Sciences Centre; London Health Sciences Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Prostate cancer; Clinical endpoint; Internal medicine; Adverse effect; Phases of clinical research; Oncology; Circulating tumor cell; Clinical trial; Cancer; Surgery; Metastasis","score_opus":0.08111566582937407,"score_gpt":0.40143433790230904,"score_spread":0.32031867207293496,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W235826207","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98078686,0.004727996,0.0009675038,0.0013834382,0.00032335526,0.003216951,0.0038823416,0.00025702603,0.0044546425],"genre_scores_gemma":[0.9766883,0.0044791247,0.002141405,0.0017040566,0.00028057554,0.0021762494,0.0067480365,0.00008611133,0.0056961784],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99956125,0.00021958104,0.00001625628,0.00005851176,0.00003744152,0.000107065156],"domain_scores_gemma":[0.9992118,0.0001131398,0.0001038971,0.00006350321,0.000032222062,0.00047544183],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015791137,0.0021517721,0.0024053988,0.0008105827,0.0006653154,0.0011708846,0.0014331151,0.0014863202,0.0063958466],"category_scores_gemma":[0.00087407616,0.0006831647,0.0024510918,0.00077390904,0.0010776889,0.0008292502,0.00045290566,0.004352221,0.0014353443],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.7299582,0.07592463,0.008237666,0.0011686449,0.0029614079,0.00043140637,0.00045689693,0.0046744924,0.044125337,0.00061358995,0.00973115,0.12171666],"study_design_scores_gemma":[0.61536443,0.3593542,0.015619735,0.000048204736,0.00085796416,0.00027791836,0.00014025295,0.0011242488,0.002800685,0.00022525777,0.004133662,0.000053408432],"about_ca_topic_score_codex":0.0050599165,"about_ca_topic_score_gemma":0.016273048,"teacher_disagreement_score":0.0063958466,"about_ca_system_score_codex":0.0012823829,"about_ca_system_score_gemma":0.0022266528,"threshold_uncertainty_score":0.02139622},"labels":[],"label_agreement":null},{"id":"W2374560515","doi":"","title":"Histone Acetylation and Cancer","year":2003,"lang":"en","type":"article","venue":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"CAE (Canada)","funders":"","keywords":"Histone methyltransferase; Histone H2A; Histone methylation; Histone; Histone code; Histone Acetyltransferases; SAP30; Acetylation; Histone H1; Biology; Chromatin; HDAC4; Histone-modifying enzymes; Chromatin remodeling; Genetics; Chemistry; Cell biology; Gene; DNA methylation; Nucleosome; Gene expression","score_opus":0.009860844630927137,"score_gpt":0.3097265162885565,"score_spread":0.2998656716576294,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2374560515","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.016231798,0.9578232,0.00089036376,0.004502746,0.0009857572,0.000027004739,0.0005323277,0.00007611956,0.018930573],"genre_scores_gemma":[0.23659745,0.72960204,0.0013891133,0.0025722468,0.000953864,0.00004419131,0.0013027496,0.000019901952,0.02751845],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99979275,0.00003789324,0.000015177553,0.000042411426,0.000067132554,0.000044720357],"domain_scores_gemma":[0.99988425,0.000016270129,0.000031130316,0.000009434819,0.000029753151,0.00002916418],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027550387,0.00034806778,0.00045942064,0.00057124544,0.00040290557,0.0007515767,0.00037215877,0.00075390475,0.0044230963],"category_scores_gemma":[0.0004074999,0.00008369541,0.00021105928,0.0013079597,0.00040726823,0.00033061887,0.0004595194,0.00068479043,0.0015780951],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009156544,0.00020982667,0.019291786,0.0041722376,0.0004077506,0.0027372364,0.00043664433,0.0008526946,0.0495119,0.029395122,0.09067546,0.8013936],"study_design_scores_gemma":[0.00007584712,0.00035933446,0.046614777,0.0005511886,0.00018459179,0.00795821,0.0002610092,0.0002273584,0.010635099,0.013246915,0.9198463,0.000039339433],"about_ca_topic_score_codex":0.0025169859,"about_ca_topic_score_gemma":0.0025674258,"teacher_disagreement_score":0.0044230963,"about_ca_system_score_codex":0.0007475915,"about_ca_system_score_gemma":0.0005996242,"threshold_uncertainty_score":0.014796674},"labels":[],"label_agreement":null},{"id":"W239648021","doi":"10.1016/j.bmc.2015.05.011","title":"Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Institute","keywords":"Chemistry; Calcitriol receptor; Histone deacetylase; Trichostatin A; Agonist; Histone deacetylase inhibitor; HDAC6; Small molecule; Biochemistry; Pharmacology; Receptor; Cancer research; Histone; Biology","score_opus":0.013097177035012241,"score_gpt":0.28943980569844063,"score_spread":0.2763426286634284,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W239648021","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9874641,0.0014206658,0.0048244353,0.00007968482,0.000034767098,0.000053644795,0.0003496376,0.00013006212,0.005643123],"genre_scores_gemma":[0.9947785,0.0006069124,0.0021842339,0.00003103735,0.0000050776407,0.000021948768,0.00022522979,0.000017843015,0.002129196],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999238,0.0000098982055,0.0000064333526,0.000016908023,0.000016036965,0.000026873262],"domain_scores_gemma":[0.9999603,0.000009470462,0.000009588092,0.000004273103,0.0000069179155,0.000009455372],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010919857,0.00022867581,0.0001808059,0.00016083632,0.000116711155,0.000266325,0.00029472605,0.00019448629,0.0020817926],"category_scores_gemma":[0.00012443497,0.00011359711,0.00018331657,0.00022112376,0.000074631986,0.00019598333,0.00015345072,0.00030108244,0.0005059957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047236602,0.00010361286,0.00017773917,0.000098052195,0.000026345204,0.00009671975,0.000034439752,0.001232224,0.98940545,0.0007084899,0.00014933292,0.0074952333],"study_design_scores_gemma":[0.00004121873,0.00061828917,0.00039416255,0.000004137061,0.000028034921,0.0000717798,0.000021007681,0.0009695885,0.99387145,0.00005076154,0.0039202664,0.000009242644],"about_ca_topic_score_codex":0.000434346,"about_ca_topic_score_gemma":0.0010098274,"teacher_disagreement_score":0.0020817926,"about_ca_system_score_codex":0.00026696944,"about_ca_system_score_gemma":0.00014887338,"threshold_uncertainty_score":0.0069642663},"labels":[],"label_agreement":null},{"id":"W2397257099","doi":"10.1038/srep15900","title":"The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Department of Medicine, University of California, San Francisco; University of California, San Francisco; Ministry of Science and Technology, Taiwan; National Science Council; Johns Hopkins University; Howard Hughes Medical Institute","keywords":"Survivin; AMPK; Cancer research; MAPK/ERK pathway; Protein kinase A; Cyclin D1; Apoptosis; Chemistry; Kinase; Cell growth; Programmed cell death; Colorectal cancer; Cell biology; Biology; Cancer; Cell cycle; Medicine; Biochemistry; Internal medicine","score_opus":0.01398978042690343,"score_gpt":0.28533355289945284,"score_spread":0.2713437724725494,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2397257099","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9921491,0.0051928223,0.000745799,0.00008619939,0.00003815631,0.00003049796,0.00027494613,0.000058367878,0.0014241855],"genre_scores_gemma":[0.9944945,0.0027594669,0.0007935506,0.00006603214,0.000010409977,0.00002069752,0.00042068638,0.000005550013,0.0014290833],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999708,0.000004607095,0.0000031482505,0.0000059063996,0.000006442957,0.000009130552],"domain_scores_gemma":[0.99997413,0.0000026131283,0.000008285913,0.0000017977983,0.0000035653347,0.0000094983425],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005646702,0.0003200663,0.0002106598,0.00015925913,0.00010254773,0.0001085436,0.000114176364,0.00016626455,0.00094282394],"category_scores_gemma":[0.000041181283,0.000078022815,0.00017344489,0.00013117581,0.00009462552,0.00011864737,0.000100053694,0.00033602858,0.00015143765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004274311,0.00010013609,0.00025638528,0.00018342928,0.000012028546,0.00008435714,0.000019183124,0.00015099606,0.9932823,0.00007365357,0.000121650504,0.005288318],"study_design_scores_gemma":[0.00009704896,0.003195536,0.005646226,0.000016238984,0.000047730347,0.0002602287,0.00003562871,0.00072663615,0.9854306,0.00003679648,0.0044988384,0.000008563915],"about_ca_topic_score_codex":0.00047348725,"about_ca_topic_score_gemma":0.0011745616,"teacher_disagreement_score":0.00094282394,"about_ca_system_score_codex":0.00012819422,"about_ca_system_score_gemma":0.00011695101,"threshold_uncertainty_score":0.0031540394},"labels":[],"label_agreement":null},{"id":"W2406330856","doi":"10.1080/10428194.2016.1180684","title":"Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors","year":2016,"lang":"en","type":"letter","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Cancer Institute; Doris Duke Charitable Foundation; Roche; Canadian Institutes of Health Research; Novartis; American Society of Hematology; Samuel Waxman Cancer Research Foundation","keywords":"Histone deacetylase; Cancer research; Gene signature; Proteasome; Histone; HDAC11; Histone deacetylase inhibitor; Gene; Proteasome inhibitor; Biology; Chemistry; Gene expression; Cell biology; Genetics","score_opus":0.005991476028193569,"score_gpt":0.22485079635543084,"score_spread":0.21885932032723726,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2406330856","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6407252,0.009484039,0.007041399,0.2578055,0.009352272,0.0003865989,0.0014896161,0.0006883889,0.07302705],"genre_scores_gemma":[0.93635136,0.003237658,0.0024781374,0.03842199,0.006361892,0.00012751229,0.0004319177,0.00007075003,0.012518668],"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996562,0.00008738767,0.000043803837,0.00005389809,0.00009535419,0.00006330067],"domain_scores_gemma":[0.9989938,0.00052701787,0.00011520188,0.000121749166,0.00013171257,0.0001105318],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036715422,0.00027579034,0.0004862932,0.0003269216,0.00033858413,0.0005150624,0.00031371543,0.0017827267,0.002914076],"category_scores_gemma":[0.0019203777,0.00012297172,0.0002550052,0.00031822216,0.00048631243,0.0003340626,0.00014084844,0.0016933243,0.001773454],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.007260754,0.0007854472,0.18075183,0.0004230401,0.000120792436,0.23866817,0.00059503096,0.0010415965,0.16116436,0.005809488,0.2265123,0.17686707],"study_design_scores_gemma":[0.000739182,0.002585871,0.2833868,0.00026601797,0.0001884532,0.4200928,0.0008710631,0.0102690505,0.058302566,0.015981974,0.20720817,0.00010799718],"about_ca_topic_score_codex":0.00025845057,"about_ca_topic_score_gemma":0.00044351915,"teacher_disagreement_score":0.002914076,"about_ca_system_score_codex":0.00051387126,"about_ca_system_score_gemma":0.00013478441,"threshold_uncertainty_score":0.0097485185},"labels":[],"label_agreement":null},{"id":"W2408404567","doi":"10.1021/acs.jproteome.5b01156","title":"Unraveling Site-Specific and Combinatorial Histone Modifications Using High-Resolution Mass Spectrometry in Histone Deacetylase Mutants of Fission Yeast","year":2016,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Histone; Acetylation; Histone H4; Histone deacetylase; Histone H2A; Schizosaccharomyces pombe; Histone code; Histone methyltransferase; Histone H3; Biology; Heterochromatin protein 1; Histone methylation; Epigenetics; Histone octamer; Heterochromatin; HDAC4; HDAC11; Genetics; Mutant; Chromatin; Nucleosome; Gene; DNA methylation; Gene expression","score_opus":0.05200562722664731,"score_gpt":0.3675856460088379,"score_spread":0.3155800187821906,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2408404567","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98152244,0.0010935527,0.015542838,0.00014650883,0.000030088948,0.000024380954,0.0011026256,0.00016994381,0.00036768249],"genre_scores_gemma":[0.9776087,0.0010372988,0.01937316,0.00009111566,0.000007943357,0.00002159799,0.0010350898,0.000090743466,0.000734318],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989605,0.000009208041,0.0000101975065,0.000030211766,0.000038440423,0.000015911177],"domain_scores_gemma":[0.99987113,0.000024099738,0.000048073627,0.000014127407,0.000020222802,0.000022292525],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020312189,0.00041757303,0.0002698782,0.00020711802,0.00015243018,0.00033734928,0.00034238974,0.000354664,0.00031572543],"category_scores_gemma":[0.00016618182,0.00016596344,0.00036701775,0.00021028752,0.00021819482,0.00022705701,0.0001840299,0.0005604516,0.0001689663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000046795096,0.000006545885,0.00029933627,0.00002286844,0.0000098931105,0.000054092314,0.0000088463585,0.0000855104,0.99880505,0.000032317002,0.0000143851685,0.00061443716],"study_design_scores_gemma":[0.000016051012,0.00010945239,0.012071501,0.0000055499545,0.000039716335,0.00040020217,0.00005962253,0.00340652,0.982021,0.00013614907,0.0017213655,0.000012864245],"about_ca_topic_score_codex":0.0014771101,"about_ca_topic_score_gemma":0.0014860414,"teacher_disagreement_score":0.0014771101,"about_ca_system_score_codex":0.00035920425,"about_ca_system_score_gemma":0.00018494815,"threshold_uncertainty_score":0.0029370785},"labels":[],"label_agreement":null},{"id":"W2412298997","doi":"10.1111/gbb.12303","title":"Dissociable roles for histone acetyltransferases p300 and PCAF in hippocampus and perirhinal cortex‐mediated object memory","year":2016,"lang":"en","type":"article","venue":"Genes Brain & Behavior","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"PCAF; Histone Acetyltransferases; Histone acetyltransferase; P300-CBP Transcription Factors; Acetyltransferase; CREB-binding protein; Histone; Neuroscience; Hippocampus; Perirhinal cortex; Chemistry; Acetylation; Cell biology; Biology; Biochemistry; CREB; Transcription factor; Recognition memory","score_opus":0.010460225500742111,"score_gpt":0.2910627267492256,"score_spread":0.2806025012484835,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2412298997","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900871,0.0036405325,0.0040263217,0.00010092285,0.000021906362,0.000031465417,0.0002948331,0.00010026599,0.0016966788],"genre_scores_gemma":[0.9934035,0.0012253892,0.002322212,0.0000684224,0.0000130916505,0.00006201128,0.00049194176,0.000017724424,0.0023955614],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987686,0.0000059175936,0.000007219056,0.00003178591,0.000036832727,0.000041314117],"domain_scores_gemma":[0.99988174,0.000013710146,0.000029816336,0.000016845717,0.000014116002,0.00004384386],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013075372,0.0004999781,0.0003147979,0.00034306655,0.00014839506,0.00030281025,0.0003139874,0.00030412144,0.00077049655],"category_scores_gemma":[0.0001519933,0.0001801003,0.00038357067,0.0001125626,0.00043878928,0.00036585063,0.000273741,0.000613002,0.00027240824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014846021,0.00001585593,0.0002783234,0.000027868338,0.0000060570637,0.000057190682,0.000010884565,0.000022184657,0.99760795,0.000101054036,0.000011126863,0.0017131324],"study_design_scores_gemma":[0.00003810696,0.0004211837,0.045495193,0.00000704432,0.000029120978,0.0004209468,0.00004861364,0.00052490167,0.9518926,0.00025140113,0.0008546366,0.000016138207],"about_ca_topic_score_codex":0.0014547,"about_ca_topic_score_gemma":0.0024946386,"teacher_disagreement_score":0.0014547,"about_ca_system_score_codex":0.00033820732,"about_ca_system_score_gemma":0.0003934079,"threshold_uncertainty_score":0.0028924942},"labels":[],"label_agreement":null},{"id":"W2413010444","doi":"10.1007/978-1-4939-3667-0_4","title":"Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4)","year":2016,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; McGill University; Occupational Cancer Research Centre","funders":"","keywords":"HDAC4; Histone deacetylase 5; HDAC10; HDAC6; HDAC11; Histone deacetylase; Cell biology; Mef2; Cytoplasm; Nuclear export signal; Transcription factor; Histone deacetylase 2; Subcellular localization; Histone; Biology; Chemistry; Biochemistry; Enhancer; Cell nucleus; Gene","score_opus":0.017932189778620444,"score_gpt":0.3850185517724597,"score_spread":0.36708636199383926,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2413010444","genre_codex":"empirical","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94960517,0.0076014157,0.025823535,0.0010936925,0.00033640375,0.00016222704,0.005408576,0.0002817042,0.009687254],"genre_scores_gemma":[0.9409914,0.0038827832,0.02069816,0.00031982275,0.0000865626,0.00011133466,0.013300302,0.00013334535,0.020476319],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984837,0.000017002176,0.000012285839,0.000029207948,0.00004080812,0.00005238417],"domain_scores_gemma":[0.9998425,0.00002556816,0.000023985827,0.000025550562,0.000043218035,0.000039070015],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026338192,0.00047394852,0.00026988413,0.00060233544,0.00040776414,0.00043219991,0.00081672566,0.0003622209,0.003704332],"category_scores_gemma":[0.0003083807,0.00026783653,0.0007050087,0.00039824855,0.00035174564,0.00039332654,0.000247565,0.0008293379,0.0012739331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015682238,0.000043412325,0.0006071558,0.000052515094,0.00002438748,0.000050020346,0.000009333349,0.00020211484,0.9959687,0.0005178459,0.00015506675,0.0022127433],"study_design_scores_gemma":[0.00003362745,0.00015668664,0.0063119973,0.0000056704994,0.00004987373,0.00026183855,0.000035444442,0.0015593132,0.9784492,0.00023708736,0.012890198,0.0000091001775],"about_ca_topic_score_codex":0.0033939774,"about_ca_topic_score_gemma":0.0027761145,"teacher_disagreement_score":0.003704332,"about_ca_system_score_codex":0.0009839203,"about_ca_system_score_gemma":0.0007588729,"threshold_uncertainty_score":0.012392223},"labels":[],"label_agreement":null},{"id":"W2418126378","doi":"10.1007/978-81-322-2574-4_1","title":"Potential Molecular Targets: From Bench to Bedside","year":2012,"lang":"en","type":"book-chapter","venue":"Head and neck cancer clinics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Mount Sinai Hospital; University of Toronto; York University","funders":"","keywords":"PI3K/AKT/mTOR pathway; Head and neck squamous-cell carcinoma; Radiation therapy; Wnt signaling pathway; Medicine; Cancer research; Epidermal growth factor receptor; Bioinformatics; Protein kinase B; Signal transduction; Cancer; Biology; Head and neck cancer; Internal medicine","score_opus":0.017699509724542675,"score_gpt":0.3195044950655606,"score_spread":0.30180498534101796,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2418126378","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0013392752,0.86015666,0.012545162,0.021547766,0.006672242,0.000042990334,0.00019953477,0.00034452177,0.09715187],"genre_scores_gemma":[0.016063478,0.7661998,0.018442327,0.015916072,0.0062270183,0.00015844581,0.0003332968,0.00021012708,0.17644936],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997732,0.000042179916,0.000010833608,0.000039642808,0.00010885925,0.000025360438],"domain_scores_gemma":[0.9998355,0.00008708319,0.000009097463,0.000011065685,0.000032142336,0.000025079311],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006638391,0.000824424,0.0009887132,0.0007909592,0.00042046438,0.0024040877,0.0011563766,0.001523275,0.020006381],"category_scores_gemma":[0.0005719144,0.0005089391,0.00034078184,0.000721206,0.0008334082,0.0037765845,0.001051051,0.0037052403,0.009990552],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012971336,0.00011259077,0.00011072794,0.0016867266,0.000023735827,0.00035011803,0.00014199523,0.0007171767,0.0136750955,0.07820248,0.29145232,0.6133973],"study_design_scores_gemma":[0.000018896051,0.00006995552,0.000121824596,0.00039109716,0.000014130492,0.0005367913,0.00006630453,0.00028639883,0.0020957734,0.033852603,0.9625309,0.000015242611],"about_ca_topic_score_codex":0.00036226044,"about_ca_topic_score_gemma":0.0015148923,"teacher_disagreement_score":0.020006381,"about_ca_system_score_codex":0.0011072193,"about_ca_system_score_gemma":0.000674633,"threshold_uncertainty_score":0.06692803},"labels":[],"label_agreement":null},{"id":"W2435392671","doi":"10.1093/neuonc/now075.66","title":"LG-66CLINICAL AND TREATMENT FACTORS DETERMINING LONG-TERM OUTCOMES FOR ADULT SURVIVORS OF CHILDHOOD LOW-GRADE GLIOMA: A POPULATION-BASED STUDY","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Pediatric Oncology Group; SickKids Foundation; Occupational Cancer Research Centre; Hospital for Sick Children","funders":"","keywords":"Glioma; Term (time); Medicine; Pediatrics; Physics; Cancer research","score_opus":0.034365346073860555,"score_gpt":0.3590180884324387,"score_spread":0.32465274235857816,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2435392671","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99919564,0.00014168341,0.000026337108,0.000020165282,0.0000012540931,0.0000043745945,0.00041630166,0.0000016560537,0.00019263083],"genre_scores_gemma":[0.9992955,0.00008738572,0.000020712861,0.000010874069,0.0000023820278,0.0000030187473,0.0005044299,8.968796e-7,0.00007484875],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9997845,0.00002239135,0.000017561786,0.000051570216,0.000062046645,0.00006193067],"domain_scores_gemma":[0.99942267,0.00003414408,0.00029916168,0.000043387583,0.00009016956,0.00011042603],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026634682,0.00023761195,0.00023241832,0.0004286029,0.0004276306,0.00045494628,0.00040877855,0.00028199158,0.0008773843],"category_scores_gemma":[0.00095025456,0.00018214434,0.00028555767,0.0009873107,0.00029751193,0.00032316186,0.00030627724,0.00033429803,0.00018981403],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00002580102,0.0000057570355,0.9994837,0.0000023186021,0.000009391315,0.000022273965,0.000028226996,0.000008528543,0.00005448622,0.0000025196312,0.000028785396,0.00032807045],"study_design_scores_gemma":[0.0000016251768,0.000024088695,0.99971896,0.0000015959166,0.000007950012,0.00006760798,0.00007020791,0.00002426827,0.000011068099,0.0000031753,0.00006860084,8.708898e-7],"about_ca_topic_score_codex":0.1446944,"about_ca_topic_score_gemma":0.21723847,"teacher_disagreement_score":0.1446944,"about_ca_system_score_codex":0.00146639,"about_ca_system_score_gemma":0.001226389,"threshold_uncertainty_score":0.28770435},"labels":[],"label_agreement":null},{"id":"W2435918492","doi":"10.1200/jco.2016.68.0926","title":"Reply to F. Felix et al and M.F. Fay et al","year":2016,"lang":"fr","type":"letter","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Genentech; National Cancer Institute; Celgene; Pfizer","keywords":"Medicine; Humanities; Philosophy","score_opus":0.08324012119421662,"score_gpt":0.4856046482209168,"score_spread":0.4023645270267002,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2435918492","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00019473373,0.0015103157,0.00004840972,0.9811047,0.01622614,0.000005756782,0.00004740738,0.000020064743,0.00084234553],"genre_scores_gemma":[0.0037877169,0.0015982107,0.00014635712,0.95478505,0.03505099,0.000029977296,0.00004517135,0.000023641553,0.004532798],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99809784,0.0005687523,0.00019385511,0.00027449714,0.0005680119,0.00029710718],"domain_scores_gemma":[0.99503857,0.0024748289,0.0004177901,0.00017727805,0.0010545538,0.00083701225],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0029097523,0.0008175506,0.0013632547,0.000791533,0.0028457297,0.0027780056,0.0018153846,0.04031938,0.0068377783],"category_scores_gemma":[0.022283407,0.00074144197,0.0011064828,0.00061684166,0.0029382398,0.0033952536,0.0013534237,0.030331586,0.008061927],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005832086,0.000012882097,0.00029444855,0.000027555707,0.000007228407,0.0009597816,0.000052166077,0.00002549247,0.0000700913,0.00090882566,0.99455243,0.0030307164],"study_design_scores_gemma":[0.0002173291,0.000110112764,0.0012998582,0.00026758516,0.000046311106,0.007192845,0.00045705502,0.0004233576,0.00062177447,0.01049208,0.97876495,0.00010662404],"about_ca_topic_score_codex":0.0032345778,"about_ca_topic_score_gemma":0.003775887,"teacher_disagreement_score":0.04031938,"about_ca_system_score_codex":0.002820996,"about_ca_system_score_gemma":0.0023999277,"threshold_uncertainty_score":0.022874653},"labels":[],"label_agreement":null},{"id":"W2465999258","doi":"10.1038/srep29086","title":"A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Fondation Pierre Mercier; Università degli Studi di Perugia; Université de Genève; Ministero dell’Istruzione, dell’Università e della Ricerca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"HDAC6; Acetylation; Chemistry; Virtual screening; Histone deacetylase; Hydrazide; In vitro; Biochemistry; Histone; Cancer research; Computational biology; Biology; Drug discovery","score_opus":0.011038886873947102,"score_gpt":0.2785995384006583,"score_spread":0.2675606515267112,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2465999258","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.4351471,0.035781395,0.47322127,0.002392809,0.00047217193,0.003927286,0.007135369,0.0031716442,0.038750857],"genre_scores_gemma":[0.68269736,0.029809834,0.26748827,0.0010485613,0.00010258277,0.0018440922,0.0082143,0.0002524948,0.008542551],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973375,0.000044072192,0.00002405457,0.00006646742,0.000079620164,0.00005201325],"domain_scores_gemma":[0.99987876,0.000032258366,0.000022816084,0.000020787362,0.000029188117,0.000016257909],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005010465,0.0011468754,0.0014597547,0.0007963428,0.00033468165,0.0009919022,0.0010375027,0.00053895055,0.004015622],"category_scores_gemma":[0.0006429122,0.0005126125,0.0010278338,0.00075658713,0.00043046882,0.0007777365,0.0008069394,0.0013386416,0.0016637073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016455317,0.0015992366,0.002671288,0.0039757006,0.0004301667,0.001970449,0.00022956896,0.09837929,0.60821813,0.04026569,0.009226768,0.23138826],"study_design_scores_gemma":[0.002593132,0.0076603186,0.002716886,0.00054126984,0.001139673,0.003820286,0.00030302143,0.19319311,0.57118464,0.01956438,0.19696914,0.00031409817],"about_ca_topic_score_codex":0.00066883495,"about_ca_topic_score_gemma":0.0019172718,"teacher_disagreement_score":0.004015622,"about_ca_system_score_codex":0.0006589231,"about_ca_system_score_gemma":0.0011499838,"threshold_uncertainty_score":0.013433576},"labels":[],"label_agreement":null},{"id":"W2479335544","doi":"10.1158/1538-7445.am2016-1981","title":"Abstract 1981: Histone demethyalase JMJD1A promotes the DNA damage response of prostate cancer cells","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"DNA damage; Ectopic expression; Gene knockdown; Prostate cancer; Histone; Cancer research; DNA repair; Molecular biology; Cancer cell; Biology; Cancer; DNA; Chemistry; Cell culture; Genetics","score_opus":0.037109634228147816,"score_gpt":0.3941290600964328,"score_spread":0.35701942586828495,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2479335544","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.75391304,0.11049126,0.020731466,0.008365582,0.008814504,0.0003403638,0.010939584,0.001962323,0.084441856],"genre_scores_gemma":[0.8259319,0.016503178,0.004057084,0.00061288045,0.00062106305,0.00008285683,0.007449808,0.00008955321,0.14465171],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9998529,0.0000122412075,0.0000140549055,0.0000388495,0.000054725057,0.000027211374],"domain_scores_gemma":[0.9999076,0.0000062086106,0.00001893289,0.000008889421,0.000021237709,0.000037072863],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019345596,0.0003993583,0.00034356865,0.0004142956,0.00044120202,0.00040466432,0.0003137989,0.00033966475,0.014319965],"category_scores_gemma":[0.00013659526,0.00017085372,0.00028814236,0.0003984058,0.00019423038,0.00028419858,0.00042740442,0.0006991889,0.0034829658],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036488727,0.000057039117,0.0006805488,0.00044813982,0.000024724084,0.00032693846,0.00003457882,0.000080032725,0.97682494,0.0006123587,0.004842775,0.015703054],"study_design_scores_gemma":[0.0000765442,0.00045910012,0.027463239,0.000056618872,0.00005496928,0.001216112,0.00007779491,0.0007682742,0.8537472,0.0004266757,0.115634285,0.000019308773],"about_ca_topic_score_codex":0.0010809231,"about_ca_topic_score_gemma":0.0013558464,"teacher_disagreement_score":0.014319965,"about_ca_system_score_codex":0.0005032713,"about_ca_system_score_gemma":0.0003001441,"threshold_uncertainty_score":0.047905028},"labels":[],"label_agreement":null},{"id":"W2483031173","doi":"10.1158/1538-7445.am2016-4526","title":"Abstract 4526: Proscillaridin A effects on chromatin modifications and oncogene degradation in acute lymphoblastic leukemia","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Epigenetics; Chromatin; Cancer research; Cell cycle; Histone; Oncogene; Epigenetic therapy; Biology; Cancer; Medicine; DNA methylation; Gene expression; Internal medicine; Genetics; DNA; Gene","score_opus":0.031775199837238755,"score_gpt":0.3589140377913973,"score_spread":0.32713883795415855,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2483031173","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99566287,0.0018061958,0.00047990022,0.000060092054,0.000022974067,0.00003197625,0.00065583986,0.000038548143,0.001241543],"genre_scores_gemma":[0.99553865,0.00093742745,0.0006609526,0.000060388214,0.000008875303,0.000029998435,0.0013874014,0.0000070999986,0.0013691494],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999255,0.000023257418,0.00000938242,0.000011142335,0.000013107149,0.000017589622],"domain_scores_gemma":[0.9999393,0.000012487283,0.00001540066,0.000007288631,0.00000767597,0.000017891436],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103488834,0.00036791278,0.0001909595,0.0002504309,0.00010030541,0.00016435384,0.00014935982,0.0002044835,0.0025347495],"category_scores_gemma":[0.000117445525,0.00008927226,0.00015851676,0.0002368969,0.00014231456,0.00010524295,0.00010868933,0.00033955547,0.0003640335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00083778385,0.00009167,0.00021719726,0.000066638895,0.000007664221,0.00005386484,0.000007866158,0.00016448581,0.9965958,0.000043726952,0.00006565464,0.0018475374],"study_design_scores_gemma":[0.000114623006,0.0026255418,0.009586314,0.000007923853,0.000019364265,0.00020499696,0.00002277342,0.0006467097,0.98464125,0.000032153734,0.0020936246,0.000004562596],"about_ca_topic_score_codex":0.0006109978,"about_ca_topic_score_gemma":0.0005133636,"teacher_disagreement_score":0.0025347495,"about_ca_system_score_codex":0.00017956221,"about_ca_system_score_gemma":0.0001656741,"threshold_uncertainty_score":0.008479595},"labels":[],"label_agreement":null},{"id":"W2486291976","doi":"10.1158/1535-7163.mct-16-0048","title":"Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Doxorubicin; Osteosarcoma; Pharmacology; Cancer research; Mitochondrion; Medicine; Chemistry; Chemotherapy; Internal medicine; Biochemistry","score_opus":0.023481467536507372,"score_gpt":0.2965816286056582,"score_spread":0.2731001610691508,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2486291976","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92432654,0.035773102,0.03220791,0.0011513619,0.00034309697,0.00032269975,0.0003077699,0.00027613319,0.0052913544],"genre_scores_gemma":[0.96244425,0.01943277,0.012845352,0.00030881295,0.00008053156,0.000101225785,0.0003105353,0.000022642602,0.004453905],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995804,0.0000070711617,0.0000039699607,0.000013259997,0.000009749803,0.000007926798],"domain_scores_gemma":[0.999984,0.0000016725381,0.0000049312453,0.0000020457237,0.0000021340657,0.000005180607],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009864093,0.00029020262,0.00030003427,0.00029992586,0.00011837785,0.0002188937,0.00017463222,0.00022513195,0.00051585835],"category_scores_gemma":[0.000040286326,0.000113832306,0.00020335446,0.00013158222,0.00016745256,0.00033008287,0.00023014986,0.0003604938,0.00014830015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012973884,0.000106900654,0.00024972498,0.00020907787,0.000013031241,0.00016400228,0.00004515675,0.0003241373,0.9761752,0.0010969519,0.0002256247,0.021260424],"study_design_scores_gemma":[0.0003321849,0.0048056967,0.005320129,0.000106739986,0.00020288906,0.0031173062,0.00006029717,0.0038247816,0.90163815,0.00081591756,0.07972193,0.000053928834],"about_ca_topic_score_codex":0.00020240195,"about_ca_topic_score_gemma":0.00065434637,"teacher_disagreement_score":0.00051585835,"about_ca_system_score_codex":0.00019627789,"about_ca_system_score_gemma":0.00014509365,"threshold_uncertainty_score":0.0017256737},"labels":[],"label_agreement":null},{"id":"W2486727023","doi":"10.1200/jco.2013.31.15_suppl.8507","title":"Belinostat, a novel pan-histone deacetylase inhibitor (HDACi), in relapsed or refractory peripheral T-cell lymphoma (R/R PTCL): Results from the BELIEF trial.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Peripheral T-cell lymphoma; Adverse effect; Gastroenterology; Refractory (planetary science); Clinical endpoint; Lymphoma; CHOP; Clinical trial; Immunology; T cell; Immune system","score_opus":0.07275913997106148,"score_gpt":0.4122713724301568,"score_spread":0.33951223245909534,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2486727023","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9883946,0.0074003716,0.00030788232,0.0005468397,0.000062528496,0.00034245822,0.0007506466,0.00007319181,0.002121509],"genre_scores_gemma":[0.99110657,0.003634705,0.0007909898,0.0005864055,0.000121886296,0.00026751045,0.0020707673,0.000016702827,0.0014043465],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99977535,0.00012328514,0.000015393289,0.000026081141,0.000024810066,0.00003517482],"domain_scores_gemma":[0.99967706,0.00008570994,0.00008078146,0.000020569698,0.000017747294,0.0001181077],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001216118,0.00052034465,0.0006621826,0.0002171809,0.00015416113,0.00048264244,0.00034004578,0.00043690024,0.002301542],"category_scores_gemma":[0.000580732,0.00017360208,0.000487909,0.0002862031,0.0004423922,0.00055802683,0.00025745918,0.0011135198,0.00044492973],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.66414374,0.013799297,0.021513294,0.0023740637,0.0024425117,0.0004117531,0.00046934545,0.0033274943,0.046872314,0.00056033354,0.010801908,0.23328392],"study_design_scores_gemma":[0.5591893,0.3409574,0.072074704,0.00020593357,0.003227487,0.0011404876,0.0002900694,0.003370415,0.0076171923,0.00047624213,0.011395999,0.0000546383],"about_ca_topic_score_codex":0.0010072289,"about_ca_topic_score_gemma":0.003091571,"teacher_disagreement_score":0.002301542,"about_ca_system_score_codex":0.0005240496,"about_ca_system_score_gemma":0.00043887485,"threshold_uncertainty_score":0.00769943},"labels":[],"label_agreement":null},{"id":"W2486896794","doi":"10.1182/blood.v124.21.3075.3075","title":"Safe and Effective Treatment of Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma (PTCL) and Low Baseline Platelet Counts with Belinostat","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Tolerability; Peripheral T-cell lymphoma; Clinical endpoint; Vincristine; Clinical trial; Prednisone; Gastroenterology; Cyclophosphamide; CHOP; Lymphoma; Refractory (planetary science); Oncology; Adverse effect; Surgery; Chemotherapy; Immunology; T cell; Immune system","score_opus":0.002810827406808201,"score_gpt":0.20409130660820227,"score_spread":0.20128047920139405,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2486896794","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9649052,0.019221682,0.003360996,0.0019111179,0.00018232319,0.0004554317,0.0007027955,0.00023308885,0.009027482],"genre_scores_gemma":[0.99498075,0.0016009806,0.0012324122,0.0007332627,0.00011648876,0.00012834139,0.00057319243,0.000009460688,0.0006250951],"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99982506,0.000063416875,0.000019163966,0.000025377165,0.000039210725,0.000027750104],"domain_scores_gemma":[0.9997321,0.000051889452,0.00008339111,0.000018976853,0.000023351724,0.00009020763],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035226526,0.00016069898,0.0005395755,0.0002082783,0.00019938948,0.00032299553,0.00017732516,0.00023287261,0.0012217817],"category_scores_gemma":[0.00080673874,0.00009882377,0.00029695878,0.00015356854,0.0001523536,0.00034165982,0.00029186634,0.00050035474,0.0002865526],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.03257294,0.003193304,0.07253221,0.0006447456,0.00041157426,0.001683855,0.00022597342,0.0009794311,0.016612943,0.00088978535,0.01251299,0.85774016],"study_design_scores_gemma":[0.05635991,0.08434804,0.74360794,0.00065363484,0.0014747726,0.014531713,0.0005144333,0.008179842,0.013384347,0.0038762,0.07297041,0.00009870791],"about_ca_topic_score_codex":0.00026598267,"about_ca_topic_score_gemma":0.0010986803,"teacher_disagreement_score":0.0012217817,"about_ca_system_score_codex":0.00034145746,"about_ca_system_score_gemma":0.0005306673,"threshold_uncertainty_score":0.0040872693},"labels":[],"label_agreement":null},{"id":"W2488197870","doi":"10.1158/1535-7163.mct-16-0211","title":"FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; British Lung Foundation; Cancer Research UK; Wellcome Trust; Department of Education and Learning, Northern Ireland","keywords":"Mediator; Lung cancer; Cancer research; Cancer; Flip; Medicine; Oncology; Biology; Immunology; Internal medicine; Genetics; Apoptosis","score_opus":0.009561578925680396,"score_gpt":0.28395312735813805,"score_spread":0.27439154843245767,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2488197870","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96189255,0.025924325,0.0047192797,0.0008402806,0.00018606285,0.00015545289,0.0007824222,0.0002403093,0.0052593173],"genre_scores_gemma":[0.9914874,0.004858017,0.00063018186,0.00015159594,0.000033899352,0.000047430825,0.0006201933,0.000013688296,0.0021575275],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999124,0.000016087239,0.0000074958234,0.00001572374,0.000026364422,0.000021997732],"domain_scores_gemma":[0.9999443,0.0000066640087,0.00002063464,0.0000045932247,0.0000090161875,0.000014715344],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731128,0.00027955536,0.000257192,0.00018797998,0.00017981493,0.00032087535,0.00018201639,0.00034178866,0.0017438369],"category_scores_gemma":[0.00013954489,0.000103315106,0.00018497725,0.00012642935,0.0002148699,0.0002612643,0.000179935,0.00060814637,0.00044175374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014403144,0.000040572617,0.0005735112,0.00021427327,0.0000150842125,0.00023118871,0.00001430654,0.000108334374,0.99045676,0.00027516432,0.00033571917,0.007591049],"study_design_scores_gemma":[0.00010456738,0.0011789607,0.021510772,0.00004696279,0.00008836556,0.0035301577,0.000085409076,0.0017172943,0.95348454,0.0003657883,0.017867358,0.000019852912],"about_ca_topic_score_codex":0.00016437891,"about_ca_topic_score_gemma":0.0002594344,"teacher_disagreement_score":0.0017438369,"about_ca_system_score_codex":0.0003429933,"about_ca_system_score_gemma":0.0001771526,"threshold_uncertainty_score":0.0058336854},"labels":[],"label_agreement":null},{"id":"W2491547442","doi":"10.1210/me.2016-1072","title":"Minireview: The Link Between ERα Corepressors and Histone Deacetylases in Tamoxifen Resistance in Breast Cancer","year":2016,"lang":"en","type":"review","venue":"Molecular Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Biology; Breast cancer; Tamoxifen; Histone; Cancer research; Internal medicine; Cancer; Oncology; Genetics; Gene; Medicine","score_opus":0.025901009168598745,"score_gpt":0.36127071663837396,"score_spread":0.33536970746977524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2491547442","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0001692936,0.9831306,0.00028751523,0.0017820996,0.011200697,0.000014121915,0.000058763875,0.000044951106,0.0033121041],"genre_scores_gemma":[0.0009726984,0.98418033,0.00028152455,0.0011710931,0.0076257302,0.000016005373,0.0001291762,0.000012155986,0.0056113596],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997938,0.000034205725,0.000023417282,0.000035461973,0.000090208385,0.000022935526],"domain_scores_gemma":[0.9995302,0.00015329159,0.00005432221,0.000014637546,0.00015316081,0.00009441238],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000451432,0.0012152236,0.0011981135,0.0015567822,0.0003375431,0.0011417983,0.0011688754,0.0011818694,0.011064645],"category_scores_gemma":[0.00083141413,0.00025614217,0.00046829996,0.0019698977,0.00043235032,0.0016846403,0.0006584423,0.002321353,0.008186698],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009564792,0.00007187362,0.00013734894,0.012325134,0.00010292917,0.00025181708,0.00007422072,0.00033510977,0.0022347427,0.0021954726,0.46989223,0.5122835],"study_design_scores_gemma":[0.0000066758757,0.000034316043,0.00034516404,0.0007631419,0.000038790422,0.0005481323,0.000023313743,0.000030569674,0.000168972,0.0006826243,0.9973515,0.0000067021383],"about_ca_topic_score_codex":0.00049919373,"about_ca_topic_score_gemma":0.00087156537,"teacher_disagreement_score":0.011064645,"about_ca_system_score_codex":0.00074475957,"about_ca_system_score_gemma":0.0010099699,"threshold_uncertainty_score":0.03701496},"labels":[],"label_agreement":null},{"id":"W2494068176","doi":"10.1158/1538-7445.am2016-lb-046","title":"Abstract LB-046: Mechanism and consequences of HDAC6 regulation by RanBPM","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"HDAC6; Downregulation and upregulation; Cortactin; Cell biology; Cancer research; Microtubule; Biology; Chemistry; Histone deacetylase; Cell; Cytoskeleton; Histone; Genetics; Gene","score_opus":0.03853102373983399,"score_gpt":0.3775140445110598,"score_spread":0.33898302077122583,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2494068176","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9636479,0.01855398,0.008749379,0.00060984056,0.00024492323,0.00008750563,0.001947491,0.00034400623,0.0058150017],"genre_scores_gemma":[0.9871011,0.0015612568,0.0016933655,0.00012948002,0.00004053933,0.000051019128,0.0027367834,0.000042965938,0.0066435286],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998523,0.00002421715,0.000011270186,0.00003433398,0.000033552104,0.000044278808],"domain_scores_gemma":[0.9999323,0.0000047987305,0.000018014292,0.000008623402,0.000010053111,0.000026247886],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351825,0.0003839647,0.0002941231,0.0001976215,0.00026835717,0.00031767593,0.0004906471,0.00029534235,0.0034331817],"category_scores_gemma":[0.00008045903,0.00012386801,0.00050062616,0.00015475275,0.00023950206,0.00015048201,0.00024439284,0.0005176335,0.0019752278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026824957,0.000026566588,0.0002424975,0.00006992479,0.000009534811,0.000100847275,0.000004765426,0.000038420818,0.9977824,0.00017463992,0.00010280248,0.0011794239],"study_design_scores_gemma":[0.00003957683,0.00014466568,0.0066089807,0.000008659271,0.00001893732,0.00037786918,0.00001771549,0.0010322368,0.9871133,0.00010139748,0.0045307996,0.0000058792275],"about_ca_topic_score_codex":0.00073033106,"about_ca_topic_score_gemma":0.0005859933,"teacher_disagreement_score":0.0034331817,"about_ca_system_score_codex":0.0004400197,"about_ca_system_score_gemma":0.00015169491,"threshold_uncertainty_score":0.0114851},"labels":[],"label_agreement":null},{"id":"W2505545269","doi":"10.1182/blood.v116.21.1763.1763","title":"Mocetinostat (MGCD0103), An Isotype-Selective Histone Deacetylase (HDAC) Inhibitor, Produces Clinical Responses In Relapsed/Refractory Hodgkin Lymphoma (HL): Update From a Phase II Clinical Study","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Cohort; Internal medicine; Adverse effect; Population; Gastroenterology; Refractory (planetary science); Phases of clinical research; Tolerability; Progressive disease; Surgery; Clinical trial; Chemotherapy","score_opus":0.028225977949934845,"score_gpt":0.3921089692585946,"score_spread":0.36388299130865975,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2505545269","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9705282,0.02254361,0.000895971,0.00034649362,0.000056250152,0.0010266531,0.001086243,0.00010971355,0.003406921],"genre_scores_gemma":[0.98482716,0.00909093,0.0014613708,0.0007469207,0.00009467557,0.00037230126,0.002236148,0.000023927872,0.00114665],"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99974054,0.00012027815,0.000024990599,0.000028723654,0.000047743793,0.000037666152],"domain_scores_gemma":[0.99944526,0.00020925755,0.00013457856,0.000036894926,0.00006307059,0.00011088293],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018361579,0.00033568713,0.0008138671,0.00026483485,0.00013031097,0.0005049427,0.00027190277,0.00028564318,0.0014475873],"category_scores_gemma":[0.00067073427,0.00014962195,0.0004075275,0.00032668986,0.00024585307,0.0002493799,0.00013961118,0.00095448154,0.0003276296],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.102286555,0.013026338,0.08140412,0.0023469292,0.0015643435,0.00039768917,0.00039632243,0.0022632382,0.116262935,0.0003970819,0.008993247,0.67066115],"study_design_scores_gemma":[0.12125047,0.511382,0.25792924,0.0005887971,0.002421728,0.002974368,0.00025805124,0.0037900973,0.05111808,0.00042098376,0.047776844,0.000089382425],"about_ca_topic_score_codex":0.00042293622,"about_ca_topic_score_gemma":0.001247391,"teacher_disagreement_score":0.0018361579,"about_ca_system_score_codex":0.00040802892,"about_ca_system_score_gemma":0.00042696914,"threshold_uncertainty_score":0.00971061},"labels":[],"label_agreement":null},{"id":"W2514024468","doi":"10.1186/s12885-016-2604-7","title":"HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma","year":2016,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; University of Toronto","keywords":"HDAC6; Clear cell renal cell carcinoma; Cancer research; Biology; Cell migration; Chromatin immunoprecipitation; Cell culture; Histone; Histone deacetylase; Renal cell carcinoma; Gene expression; Medicine; Pathology; Gene; Promoter","score_opus":0.012622321787346048,"score_gpt":0.24733938562216184,"score_spread":0.2347170638348158,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2514024468","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9938711,0.0045046243,0.00032003276,0.00006111305,0.000019200224,0.000014742425,0.0004964807,0.000024548282,0.0006881727],"genre_scores_gemma":[0.99635017,0.0014774055,0.00036877135,0.000032242217,0.0000093253475,0.000019323748,0.0007775282,0.0000055509645,0.0009596299],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990594,0.00001190056,0.0000065915597,0.000016491373,0.000032079923,0.000027064749],"domain_scores_gemma":[0.9999448,0.0000074433515,0.000018669018,0.0000037914888,0.000009240609,0.000015985981],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013224207,0.00020809172,0.00028879003,0.00027084947,0.00015685607,0.00026325163,0.00012363531,0.00018854399,0.001342574],"category_scores_gemma":[0.00011379746,0.0001015201,0.0002789007,0.00023932288,0.00013685835,0.00014025766,0.00012632222,0.00030174656,0.0003257537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018004286,0.00020871806,0.026994264,0.00031411726,0.000064880885,0.00014528118,0.00009278393,0.00029493225,0.95890135,0.00006495481,0.0004699983,0.010648287],"study_design_scores_gemma":[0.00014871349,0.0021361273,0.4796211,0.000025945628,0.00021053955,0.00092577835,0.000338589,0.00213065,0.50764847,0.00007972891,0.006713525,0.000020850503],"about_ca_topic_score_codex":0.0014515463,"about_ca_topic_score_gemma":0.003078481,"teacher_disagreement_score":0.0014515463,"about_ca_system_score_codex":0.00030017816,"about_ca_system_score_gemma":0.0002121955,"threshold_uncertainty_score":0.004491329},"labels":[],"label_agreement":null},{"id":"W2515133122","doi":"10.1038/nchembio.2158","title":"HDAC6 finally crystal clear","year":2016,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"HDAC6; Computational biology; Chemistry; Crystallography; Biology; Biochemistry; Histone; DNA","score_opus":0.006613389870461875,"score_gpt":0.2793730046179343,"score_spread":0.2727596147474724,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2515133122","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.004922514,0.016906906,0.0030888554,0.8332184,0.09615455,0.00003332579,0.0004283015,0.00074172765,0.044505425],"genre_scores_gemma":[0.11606858,0.015044157,0.0032112042,0.52695376,0.033376433,0.000111075504,0.00086437375,0.0005864457,0.303784],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99902904,0.00010191333,0.000056276946,0.00013633713,0.00045631063,0.00022001797],"domain_scores_gemma":[0.99899596,0.00021403076,0.00008457935,0.00011963542,0.0002127014,0.00037318905],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013286227,0.00082324137,0.0007078174,0.0002468494,0.0016205744,0.0028650286,0.00091020693,0.007623237,0.014720091],"category_scores_gemma":[0.006759432,0.00044042632,0.00073729013,0.00014825293,0.0020594578,0.002298791,0.0019164436,0.016609618,0.009293051],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024083277,0.00003346517,0.00030114292,0.0001360124,0.00005111392,0.0012298629,0.00009222248,0.00017230034,0.0063706585,0.056751393,0.908109,0.026511949],"study_design_scores_gemma":[0.000102683,0.00005253009,0.0001867203,0.00003451838,0.000017974182,0.00053374184,0.00007876786,0.00026796464,0.0064669927,0.025141507,0.96709365,0.000022914295],"about_ca_topic_score_codex":0.0024886345,"about_ca_topic_score_gemma":0.003841093,"teacher_disagreement_score":0.014720091,"about_ca_system_score_codex":0.002616923,"about_ca_system_score_gemma":0.0013386173,"threshold_uncertainty_score":0.04924357},"labels":[],"label_agreement":null},{"id":"W2516941967","doi":"10.1016/j.bmcl.2016.09.011","title":"Synthesis of a selective HDAC6 inhibitor active in neuroblasts","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Université de Poitiers; Université de Genève; Ligue Contre le Cancer; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Centre National de la Recherche Scientifique; European Cooperation in Science and Technology","keywords":"HDAC6; Chemistry; IC50; In vitro; In silico; Neurodegeneration; Biochemistry; Pharmacology; Histone deacetylase; Biology; Disease","score_opus":0.006151684792005515,"score_gpt":0.23257032402770716,"score_spread":0.22641863923570166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2516941967","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8552213,0.020347092,0.06951755,0.00081956305,0.0005654702,0.0009811159,0.00905082,0.0011253817,0.042371802],"genre_scores_gemma":[0.93084925,0.012340017,0.029604992,0.00022597889,0.0000698245,0.00019288504,0.0043127094,0.000113668655,0.022290658],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993443,0.000004402006,0.0000071183163,0.000014257672,0.000015742798,0.00002395831],"domain_scores_gemma":[0.9999614,0.0000031289148,0.000005705542,0.0000049434134,0.000009266054,0.000015554688],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012740966,0.0005387192,0.00039700393,0.00026987202,0.0002814187,0.00020145641,0.00045838696,0.00030833247,0.0025565142],"category_scores_gemma":[0.000053740587,0.00021125496,0.0003077278,0.00024971823,0.00011030173,0.00016092193,0.0001855349,0.00056797714,0.0013369406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018587793,0.0000502383,0.00007459816,0.00013804347,0.000016113761,0.00012338253,0.000020763855,0.00026568738,0.9905222,0.00026381292,0.00028675128,0.008052557],"study_design_scores_gemma":[0.00003869081,0.00019890004,0.00035489298,0.00000414252,0.000027365415,0.00010344082,0.0000066219445,0.00018373856,0.9908987,0.00003196633,0.008146829,0.0000045287425],"about_ca_topic_score_codex":0.0013191521,"about_ca_topic_score_gemma":0.0023595213,"teacher_disagreement_score":0.0025565142,"about_ca_system_score_codex":0.00031111937,"about_ca_system_score_gemma":0.00054287276,"threshold_uncertainty_score":0.008552372},"labels":[],"label_agreement":null},{"id":"W2521615731","doi":"10.1016/j.neo.2016.07.004","title":"Induction of Activating Transcription Factor 3 Is Associated with Cisplatin Responsiveness in Non–Small Cell Lung Carcinoma Cells","year":2016,"lang":"en","type":"article","venue":"Neoplasia","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Ontario Institute for Cancer Research; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Cisplatin; Cytotoxicity; Cancer research; Biology; Transcriptome; Cell culture; Lung cancer; ATF3; Vorinostat; Activating transcription factor; Transcription factor; Pharmacology; Histone deacetylase; Gene expression; Medicine; Chemotherapy; Histone; Oncology; In vitro; Biochemistry; Gene; Genetics; Promoter","score_opus":0.012090532552558255,"score_gpt":0.23967685591640875,"score_spread":0.22758632336385048,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2521615731","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9855245,0.0027074846,0.0029402277,0.00017605098,0.00006745683,0.00006356412,0.0058742845,0.00016575755,0.002480725],"genre_scores_gemma":[0.9892051,0.001157354,0.0018611257,0.0001707671,0.000011953244,0.00007641841,0.0054946505,0.00002800727,0.0019946904],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998271,0.000008866152,0.000013824394,0.00004654489,0.000069322654,0.000034372264],"domain_scores_gemma":[0.9998814,0.000015403233,0.00004253152,0.000009409596,0.000031670043,0.000019564059],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009518137,0.0002037057,0.00029812695,0.00030433954,0.00025964176,0.00034824767,0.00010658425,0.00022189232,0.0017148596],"category_scores_gemma":[0.00019175428,0.000148914,0.00045183042,0.00041108872,0.00016703474,0.00017393444,0.00022794113,0.00055464375,0.0005144302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001852235,0.000026333992,0.004105658,0.00008745759,0.000014004617,0.00011086622,0.000045702494,0.00010563797,0.9930218,0.00004851893,0.00025033602,0.0019984194],"study_design_scores_gemma":[0.000018987896,0.00034634117,0.24341512,0.00002846726,0.00006383961,0.00084422366,0.0003079623,0.0024430633,0.74495703,0.00018140412,0.007366913,0.000026685704],"about_ca_topic_score_codex":0.0012185503,"about_ca_topic_score_gemma":0.0021082156,"teacher_disagreement_score":0.0017148596,"about_ca_system_score_codex":0.00031462958,"about_ca_system_score_gemma":0.00025727344,"threshold_uncertainty_score":0.0057367682},"labels":[],"label_agreement":null},{"id":"W2524612296","doi":"10.1016/j.cjca.2016.07.313","title":"VALPROIC ACID INDUCES ENDOTHELIAL-TO-MESENCHYMAL-LIKE PHENOTYPIC SWITCHING","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Valproic Acid; Medicine; Mesenchymal stem cell; Cancer research; Fibrosis; Endothelium; Cell biology; Histone deacetylase; Histone deacetylase inhibitor; Pharmacology; Histone; Pathology; Internal medicine; Epilepsy; Biochemistry; Biology; Psychiatry","score_opus":0.013181591446754575,"score_gpt":0.2500862515865657,"score_spread":0.23690466013981115,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2524612296","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99356306,0.0012687071,0.00080262485,0.00019120838,0.00013023669,0.0000289616,0.00050944457,0.00008880719,0.0034169282],"genre_scores_gemma":[0.9963426,0.0005126665,0.00036686874,0.00009587518,0.000013189772,0.000013295882,0.0002877173,0.000010970187,0.0023568212],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998479,0.00003167496,0.000015059466,0.00002206573,0.00003339343,0.000049932227],"domain_scores_gemma":[0.9998896,0.00002507354,0.000020035317,0.000017569597,0.000012197874,0.00003550703],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000952352,0.00022273403,0.0002284679,0.0001761976,0.00016910443,0.00033512322,0.00012861591,0.000232719,0.0015393508],"category_scores_gemma":[0.00012184383,0.00015978466,0.0002901675,0.00014132225,0.00014051629,0.00011065665,0.00014827117,0.00073316926,0.0003308579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008191203,0.000103155304,0.00021481398,0.00003196282,0.000014607766,0.00022272689,0.000020877418,0.00009007471,0.99555606,0.0001616776,0.00018356254,0.0025813335],"study_design_scores_gemma":[0.000110962545,0.0011563865,0.008375517,0.000007772471,0.000032776046,0.00029901403,0.00009218958,0.00076313753,0.985852,0.00011645289,0.0031865474,0.0000071886143],"about_ca_topic_score_codex":0.0011486685,"about_ca_topic_score_gemma":0.002012015,"teacher_disagreement_score":0.0015393508,"about_ca_system_score_codex":0.00023361939,"about_ca_system_score_gemma":0.00026106235,"threshold_uncertainty_score":0.0051496625},"labels":[],"label_agreement":null},{"id":"W2529812226","doi":"10.1038/cddiscovery.2015.48","title":"Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis","year":2015,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Sequence (biology); Peptide; Apoptosis; Suppressor; Peptide sequence; Cell biology; Cancer research; Biology; Genetics; Gene; Biochemistry","score_opus":0.022975596107410786,"score_gpt":0.269478242372175,"score_spread":0.2465026462647642,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2529812226","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9906328,0.0012216666,0.006270818,0.00010432348,0.00003518653,0.00013708603,0.00045540425,0.00003725285,0.0011054862],"genre_scores_gemma":[0.9778797,0.0012310761,0.016374215,0.00012864394,0.000021028745,0.00016931568,0.0020760559,0.00003830242,0.002081724],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987245,0.000023064886,0.000015212701,0.000020160956,0.00003418956,0.00003483338],"domain_scores_gemma":[0.99983776,0.00003011887,0.000038402675,0.000015506586,0.000026724665,0.000051573355],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022225735,0.0003865018,0.00028406095,0.00016490341,0.00016059987,0.0003049893,0.0002548708,0.00030415508,0.001160723],"category_scores_gemma":[0.00018438013,0.0001828362,0.00025062938,0.00016115916,0.00021132144,0.00018844818,0.00016257355,0.0007042969,0.0006856093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000116841176,0.000034144072,0.00008861849,0.0000330187,0.0000025466459,0.000046054494,0.000009163935,0.00016464082,0.9986545,0.0000897727,0.000030776373,0.0007300404],"study_design_scores_gemma":[0.000050475515,0.00067510956,0.0012544044,0.000012890757,0.00001915818,0.000417787,0.000022257727,0.0010126726,0.9912219,0.000048315615,0.0052583655,0.000006745888],"about_ca_topic_score_codex":0.00031142475,"about_ca_topic_score_gemma":0.0006214488,"teacher_disagreement_score":0.001160723,"about_ca_system_score_codex":0.00034640022,"about_ca_system_score_gemma":0.00030381136,"threshold_uncertainty_score":0.0038829446},"labels":[],"label_agreement":null},{"id":"W2529935094","doi":"10.1182/blood.v112.11.3487.3487","title":"The Potent Deacetylase Inhibitor Trichostatin a (TSA) Increases CXCR4 Expression in Hematopoietic Stem/Progenitor Cells by Chromatin Remodelling","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta; Canadian Blood Services","funders":"","keywords":"Trichostatin A; Histone deacetylase; Cancer research; Biology; Progenitor cell; Haematopoiesis; Cell biology; Stem cell; Histone; Biochemistry","score_opus":0.010852995994497504,"score_gpt":0.2329938772508488,"score_spread":0.22214088125635129,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2529935094","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9942403,0.0019681053,0.0011460519,0.00010403124,0.000040506886,0.000028285163,0.00052752177,0.000055263645,0.0018899705],"genre_scores_gemma":[0.994843,0.0011810187,0.0012744296,0.000078585595,0.0000143929665,0.000031794178,0.0008055104,0.000010112183,0.0017613018],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999106,0.000014227369,0.000009112743,0.000012622506,0.000023881912,0.000029678695],"domain_scores_gemma":[0.9999573,0.000008225278,0.000009499786,0.0000056394356,0.000005026199,0.000014235309],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000081764796,0.00022115496,0.00020565807,0.00014574022,0.00010340607,0.0001321062,0.0001304098,0.00012513068,0.0016882167],"category_scores_gemma":[0.000051819166,0.000082233724,0.00029162684,0.00013950792,0.0001630127,0.00009523929,0.00012576875,0.00040536447,0.00029820797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013213808,0.000032160366,0.00017688506,0.000030054474,0.000005484691,0.00002657263,0.000009188984,0.000034586847,0.99795604,0.000037839425,0.00006664444,0.0014923711],"study_design_scores_gemma":[0.000026731479,0.0005742125,0.0041982452,0.0000025367274,0.000013914582,0.00012062199,0.000019276744,0.0003277661,0.99294704,0.000013051561,0.0017546355,0.0000018613439],"about_ca_topic_score_codex":0.0010508212,"about_ca_topic_score_gemma":0.0018894586,"teacher_disagreement_score":0.0016882167,"about_ca_system_score_codex":0.00020591983,"about_ca_system_score_gemma":0.00016402178,"threshold_uncertainty_score":0.0056476593},"labels":[],"label_agreement":null},{"id":"W2531449940","doi":"10.1158/2159-8290.cd-16-0975","title":"<i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas","year":2016,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"HDAC3; Computational biology; Biology; Cancer research; Genetics; Gene","score_opus":0.015066010863594988,"score_gpt":0.27977603109849575,"score_spread":0.26471002023490076,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2531449940","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9851922,0.0020493881,0.0048422767,0.0002616522,0.00007234993,0.00004776665,0.0015221868,0.0008713626,0.005140936],"genre_scores_gemma":[0.9938735,0.000421731,0.0012107337,0.00010147813,0.000018679348,0.000029638019,0.00095950975,0.000096743606,0.0032878646],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982786,0.000017578668,0.000012356995,0.00003360649,0.000043003856,0.00006547882],"domain_scores_gemma":[0.9998529,0.000015848052,0.000053726693,0.000016635311,0.0000104314795,0.00005039009],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013642474,0.0003984149,0.00025326668,0.00024791624,0.00013298182,0.00032668267,0.00023671922,0.0002532271,0.0030638569],"category_scores_gemma":[0.00009485581,0.00014568355,0.00030735868,0.00012978828,0.0002686854,0.00013099932,0.00023012441,0.0008285278,0.0011436163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000116432166,0.000031237516,0.00020468967,0.000020754587,0.000005496277,0.00005188184,0.0000046884993,0.000041460768,0.9982498,0.00008093382,0.00012559976,0.0010670112],"study_design_scores_gemma":[0.00002995702,0.00020387195,0.005987923,0.000006804006,0.000016004922,0.00045479226,0.000015495707,0.00086357637,0.9887267,0.000052159598,0.0036382654,0.0000046153036],"about_ca_topic_score_codex":0.0010191158,"about_ca_topic_score_gemma":0.0014263483,"teacher_disagreement_score":0.0030638569,"about_ca_system_score_codex":0.0003649124,"about_ca_system_score_gemma":0.00019084064,"threshold_uncertainty_score":0.010249615},"labels":[],"label_agreement":null},{"id":"W2533216488","doi":"10.1182/blood.v126.23.2719.2719","title":"A Randomized, Phase II Study with Biomarker Analysis of Panobinostat with or without Rituximab in Relapsed Diffuse Large B Cell Lymphoma","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Jewish General Hospital; Queen Elizabeth II Health Sciences Centre; Hôpital du Sacré-Cœur de Montréal; Simon Fraser University; Princess Margaret Cancer Centre; McGill University","funders":"","keywords":"Panobinostat; Rituximab; Medicine; Internal medicine; Oncology; Diffuse large B-cell lymphoma; Confidence interval; Lymphoma; Chemoimmunotherapy; Biology; Histone deacetylase; Histone","score_opus":0.017234985909646665,"score_gpt":0.2973524630710236,"score_spread":0.2801174771613769,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2533216488","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99301237,0.0013608036,0.0005116829,0.0003423372,0.00022526366,0.0033498523,0.0004431772,0.000056126435,0.0006984438],"genre_scores_gemma":[0.98823357,0.001101868,0.0017306191,0.0008418477,0.0003826772,0.0053050253,0.0011333999,0.000022721171,0.0012482526],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.9982432,0.0011531438,0.000074165575,0.00023406654,0.00011400119,0.00018149795],"domain_scores_gemma":[0.9978781,0.0005301413,0.00040992038,0.0002511379,0.0001331831,0.00079751736],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0035834152,0.001769821,0.003184502,0.0005185352,0.00046854952,0.0011857299,0.0010695211,0.0017478883,0.0036946114],"category_scores_gemma":[0.0023247744,0.0009589919,0.0013414104,0.00070242846,0.0018342816,0.0010646909,0.0005067663,0.002925982,0.0008676899],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.9636573,0.01764473,0.0021476438,0.00020805844,0.00062237104,0.00006089626,0.000048878817,0.00037759478,0.004434548,0.000078003475,0.00042845646,0.010291492],"study_design_scores_gemma":[0.8483671,0.14795564,0.00222129,0.000008733304,0.00021667816,0.000047915455,0.000016164813,0.00035219037,0.00041803587,0.00006566427,0.00032122992,0.000009311212],"about_ca_topic_score_codex":0.00073780783,"about_ca_topic_score_gemma":0.0012773089,"teacher_disagreement_score":0.0036946114,"about_ca_system_score_codex":0.0010854169,"about_ca_system_score_gemma":0.0018348318,"threshold_uncertainty_score":0.018951118},"labels":[],"label_agreement":null},{"id":"W2536931592","doi":"10.1007/978-1-4939-6527-4_18","title":"Evaluation of Innate Immune Gene Expression Following HDAC Inhibitor Treatment by High Throughput qPCR and PhosFlow Cytometry","year":2016,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Cancer Institute; National Institutes of Health","keywords":"Innate immune system; Flow cytometry; Gene expression; Immune system; Gene; Biology; Immunology; Genetics","score_opus":0.025917696852940895,"score_gpt":0.4066208533212952,"score_spread":0.38070315646835434,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2536931592","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.60512066,0.0034014378,0.35400274,0.0005894502,0.000865176,0.0018054394,0.018353572,0.0028733427,0.012988138],"genre_scores_gemma":[0.5858375,0.005137323,0.35086522,0.0012422088,0.00037615877,0.009971847,0.015227192,0.0010883539,0.03025428],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9981665,0.00018158942,0.00012397242,0.00058678247,0.00060701324,0.00033415944],"domain_scores_gemma":[0.99924976,0.00028030956,0.00010979038,0.000098555116,0.00020142265,0.000060087055],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014408997,0.001357607,0.0013385759,0.0010212696,0.0009235668,0.0009858729,0.00071897643,0.00082899496,0.0040300237],"category_scores_gemma":[0.00060699024,0.0006167296,0.0011750001,0.0017545652,0.0012912541,0.00072771223,0.00051505625,0.0031784547,0.001466628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013472111,0.000067764,0.00018876113,0.00007223139,0.000009184137,0.000008735262,0.000055549095,0.0001254293,0.9975599,0.0001325308,0.00007075107,0.0015744772],"study_design_scores_gemma":[0.000019914776,0.00017215051,0.0033312324,0.0000076156325,0.000028935045,0.000016418282,0.00004995024,0.0018295719,0.99313205,0.00018163255,0.0012162839,0.0000143130155],"about_ca_topic_score_codex":0.0011248677,"about_ca_topic_score_gemma":0.0030618575,"teacher_disagreement_score":0.0040300237,"about_ca_system_score_codex":0.00080030056,"about_ca_system_score_gemma":0.0008756738,"threshold_uncertainty_score":0.013481736},"labels":[],"label_agreement":null},{"id":"W2552810623","doi":"10.1182/blood.v104.11.261.261","title":"Improved Leukemia-Free Survival after Post-Consolidation Treatment with Histamine Dihydrochloride and Interleukin-2 in AML: A Randomized Phase III Trial.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Randomized controlled trial; Leukemia; Surgery","score_opus":0.00701838896968833,"score_gpt":0.25574009629980693,"score_spread":0.2487217073301186,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2552810623","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9888121,0.003113201,0.0005662033,0.00067989127,0.00035051643,0.004504411,0.00070825074,0.000117616866,0.0011477093],"genre_scores_gemma":[0.9867519,0.001882192,0.0013875343,0.0011078028,0.00057251815,0.0057812226,0.0010310794,0.000019674653,0.0014661218],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.9991392,0.00051784894,0.000049064078,0.000113189206,0.00005861347,0.00012202787],"domain_scores_gemma":[0.99879175,0.00026552269,0.00030389507,0.00011184356,0.000055312692,0.00047171453],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0025980538,0.0015286963,0.0028000989,0.0003970605,0.0005059063,0.0010773944,0.0011840808,0.0015860143,0.0048901928],"category_scores_gemma":[0.0015180396,0.0006767062,0.0014129996,0.00049508625,0.0014720227,0.0011420398,0.00048677786,0.0031323244,0.00084086694],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.97545403,0.0090074735,0.00080365967,0.00026861578,0.00039152824,0.000027754735,0.000027952443,0.0001968861,0.0023589805,0.000054902357,0.00042540542,0.010982783],"study_design_scores_gemma":[0.92521083,0.07246718,0.0012968781,0.000014165781,0.00018048442,0.000023329538,0.00000899427,0.00018837127,0.0002861871,0.000049122526,0.00026879102,0.0000057445304],"about_ca_topic_score_codex":0.0006698594,"about_ca_topic_score_gemma":0.0014248238,"teacher_disagreement_score":0.0048901928,"about_ca_system_score_codex":0.00090012455,"about_ca_system_score_gemma":0.0014728956,"threshold_uncertainty_score":0.016359389},"labels":[],"label_agreement":null},{"id":"W2557428466","doi":"10.1182/blood.v114.22.4756.4756","title":"Clinical Development of MGCD0103, An Isotype-Selective HDAC Inhibitor: Pericarditis/Pericardial Effusion in the Context of Overall Safety and Efficacy.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Medicine; Internal medicine; Neutropenia; Gastroenterology; Context (archaeology); Tolerability; Adverse effect; Febrile neutropenia; Anemia; Oncology; Surgery; Chemotherapy","score_opus":0.012929244382439802,"score_gpt":0.3053250331894924,"score_spread":0.2923957888070526,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2557428466","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91383654,0.059076224,0.0035218145,0.002044832,0.00037366714,0.00355466,0.002138572,0.00042047817,0.015033152],"genre_scores_gemma":[0.9812965,0.009030264,0.0030262773,0.0014626049,0.00022025708,0.00070139614,0.0019943195,0.00004278332,0.0022255827],"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9996431,0.00014017819,0.000031066287,0.000052378713,0.000055620254,0.000077577],"domain_scores_gemma":[0.99959975,0.00005581636,0.00008419753,0.000037977297,0.000062826744,0.0001594374],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018061547,0.0005431408,0.00089115906,0.00025765883,0.00028254784,0.000669981,0.0007160669,0.0010568519,0.002538806],"category_scores_gemma":[0.0009973856,0.00015732521,0.0005605593,0.0004126862,0.00038137863,0.00040366157,0.00029438204,0.0012304848,0.0006493008],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.07689835,0.009525023,0.021311581,0.0020029184,0.0006099364,0.001600228,0.00040816906,0.0020311766,0.21107693,0.0017018069,0.013003021,0.6598308],"study_design_scores_gemma":[0.10947641,0.5256401,0.11426954,0.00053740386,0.0015630241,0.010266883,0.00023326278,0.00472869,0.10296001,0.001249396,0.12898253,0.00009278305],"about_ca_topic_score_codex":0.0009562497,"about_ca_topic_score_gemma":0.0028098898,"teacher_disagreement_score":0.002538806,"about_ca_system_score_codex":0.0007806516,"about_ca_system_score_gemma":0.0014270575,"threshold_uncertainty_score":0.009552002},"labels":[],"label_agreement":null},{"id":"W2558346369","doi":"10.1182/blood.v112.11.3333.3333","title":"Effect of Obesity on Outcomes after Autologous Hematopoietic Stem Cell Transplantation (Auto HCT) for Multiple Myeloma (MM): An Analysis from the Center for International Blood and Marrow Transplant Research (CIBMTR).","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Melphalan; Univariate analysis; Body mass index; Proportional hazards model; Transplantation; Multiple myeloma; Overweight; Surgery; Hematopoietic stem cell transplantation; Cumulative incidence; Underweight; Total body irradiation; Gastroenterology; Chemotherapy; Multivariate analysis; Cyclophosphamide","score_opus":0.014539962080834986,"score_gpt":0.28945803007794674,"score_spread":0.27491806799711177,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2558346369","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9991892,0.0002088545,0.000042368003,0.000027695505,0.000004457997,0.0000047651865,0.00039189844,0.0000013553455,0.00012943977],"genre_scores_gemma":[0.9991042,0.00006741348,0.000022246342,0.000020681362,0.000009596745,0.0000055508553,0.0007162088,0.0000018787213,0.00005217006],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99932873,0.00024165434,0.00008192188,0.00013724515,0.00010488445,0.00010564802],"domain_scores_gemma":[0.9974107,0.0005974489,0.0011701075,0.00016581084,0.00017936224,0.00047652115],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014722785,0.00029887827,0.00032836286,0.0009157821,0.00032100812,0.00049597945,0.0003982626,0.0003875162,0.0014456119],"category_scores_gemma":[0.002218961,0.00023776287,0.0009449224,0.0011063975,0.00025085578,0.00036382015,0.0006463188,0.0005932579,0.00020180515],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043396535,0.0000213504,0.9984509,0.000006835168,0.00014588916,0.00005161117,0.000020960042,0.00004677596,0.000057879264,0.0000059824997,0.00009579533,0.00066199934],"study_design_scores_gemma":[0.000026694705,0.00014882554,0.9992361,0.000005419501,0.00010163907,0.00014431255,0.000060666516,0.00015727116,0.000025796302,0.000009416716,0.00008138425,0.0000025409074],"about_ca_topic_score_codex":0.0027241702,"about_ca_topic_score_gemma":0.0031496317,"teacher_disagreement_score":0.0027241702,"about_ca_system_score_codex":0.00032094508,"about_ca_system_score_gemma":0.00031549434,"threshold_uncertainty_score":0.007786274},"labels":[],"label_agreement":null},{"id":"W2559269147","doi":"10.1182/blood.v110.11.2571.2571","title":"Treatment of Relapsed or Refractory Lymphoma with the Oral Isotype-Selective Histone Deacetylase Inhibitor MGCD0103: Interim Results from a Phase II Study.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Follicular lymphoma; Internal medicine; Dosing; Refractory (planetary science); Lymphoma; Gastroenterology; Diffuse large B-cell lymphoma; Interim analysis; Oncology; Pharmacokinetics; Histone deacetylase inhibitor; Clinical trial; Pharmacology; Adverse effect; Histone deacetylase; Chemistry; Biology; Histone","score_opus":0.019870546665625533,"score_gpt":0.32204390535163124,"score_spread":0.3021733586860057,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2559269147","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98298347,0.00662814,0.0012393722,0.0005954251,0.00018583749,0.0034911109,0.0020023896,0.0002051996,0.0026689987],"genre_scores_gemma":[0.9777374,0.0046976507,0.003091506,0.0018737783,0.00023866852,0.0032139218,0.005579917,0.00006085284,0.0035062267],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9996921,0.00011908635,0.000019654974,0.000045940385,0.00003305083,0.000090231035],"domain_scores_gemma":[0.99936956,0.000115474264,0.00010384991,0.00006191594,0.00004625382,0.0003029221],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0019275419,0.0010915634,0.0018161996,0.00033888154,0.00032966555,0.0009362583,0.0010109552,0.0011713883,0.0035489374],"category_scores_gemma":[0.00070252613,0.00039960013,0.0012425126,0.00036279927,0.0006853045,0.00072823465,0.0003193622,0.0025671292,0.00088373653],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.58661515,0.08098616,0.007834777,0.0016830148,0.002466397,0.0005481765,0.00040107785,0.0026737258,0.05740383,0.00040481513,0.008844122,0.25013876],"study_design_scores_gemma":[0.5849873,0.3914568,0.012238962,0.00009204202,0.00061889016,0.00040823733,0.00006319606,0.0011307717,0.004283135,0.00025236115,0.004438791,0.000029455594],"about_ca_topic_score_codex":0.001339699,"about_ca_topic_score_gemma":0.0034218242,"teacher_disagreement_score":0.0035489374,"about_ca_system_score_codex":0.00091316475,"about_ca_system_score_gemma":0.0015537757,"threshold_uncertainty_score":0.011872411},"labels":[],"label_agreement":null},{"id":"W2560672496","doi":"10.1139/cjpp-2016-0542","title":"Selective inhibition of HDAC2 by magnesium valproate attenuates cardiac hypertrophy","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Magnesium; Internal medicine; Muscle hypertrophy; Cardiac hypertrophy; Endocrinology; Medicine; Pharmacology; Cardiology; Chemistry","score_opus":0.006323675529718132,"score_gpt":0.24517517635894756,"score_spread":0.23885150082922943,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2560672496","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98921984,0.005818637,0.0014337735,0.0003077485,0.00015981821,0.000057440702,0.00043138518,0.00019517838,0.0023761431],"genre_scores_gemma":[0.9928404,0.0030667935,0.001065892,0.00011221914,0.00004705974,0.00005105861,0.00054962066,0.000024436169,0.0022423996],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998952,0.000014711619,0.000012691138,0.000015266125,0.00002246191,0.000039780814],"domain_scores_gemma":[0.9999571,0.000005265627,0.000011079893,0.000005090686,0.0000045185875,0.000016993292],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012682601,0.00044650555,0.00060609134,0.0002209935,0.00016723188,0.00027868064,0.0003315595,0.00027125675,0.0013431574],"category_scores_gemma":[0.000112306465,0.00013940778,0.00032202515,0.00017931208,0.00026353364,0.00015876196,0.00017923977,0.00067412946,0.0002965316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017008979,0.00026819133,0.00031017273,0.00012627763,0.00003668849,0.00005348834,0.000021969794,0.00013366394,0.98832464,0.0001412338,0.00031640803,0.008566333],"study_design_scores_gemma":[0.00056817866,0.0050098,0.0069584907,0.000016677901,0.00010193281,0.00017721133,0.000050894447,0.0009410847,0.9803673,0.00008289379,0.0057157264,0.00000973827],"about_ca_topic_score_codex":0.001317666,"about_ca_topic_score_gemma":0.0044207447,"teacher_disagreement_score":0.0013431574,"about_ca_system_score_codex":0.0003124889,"about_ca_system_score_gemma":0.0004915077,"threshold_uncertainty_score":0.004493296},"labels":[],"label_agreement":null},{"id":"W2560740663","doi":"10.1182/blood.v112.11.3655.3655","title":"NR2F6 Initiates Myelodysplasia and Acute Leukemia by Promoting Stem Cell Self-Renewal","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Stem cell; Leukemia; Medicine; Biology; Cancer research; Internal medicine; Gerontology; Oncology; Genetics","score_opus":0.006440546198141961,"score_gpt":0.21817216950171578,"score_spread":0.2117316233035738,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2560740663","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98367083,0.0020454125,0.00337676,0.00036905365,0.00017156551,0.00005535227,0.0011564697,0.0002986662,0.008855911],"genre_scores_gemma":[0.98684365,0.0005351794,0.0018667665,0.00008005325,0.000040114348,0.000019347113,0.0008035934,0.000042640462,0.009768624],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979717,0.000039035618,0.000018372733,0.00002961251,0.0000564074,0.00005949077],"domain_scores_gemma":[0.9998685,0.000025839056,0.000018860948,0.000018854313,0.000008051813,0.000059875696],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020226343,0.00021760314,0.00017840172,0.00026023234,0.00014285323,0.00026413004,0.00017082292,0.0002386104,0.005158781],"category_scores_gemma":[0.0001617778,0.0001147494,0.00018240087,0.00009901648,0.00025360257,0.00015951764,0.00016747635,0.00055434677,0.001479418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039795772,0.000047691025,0.00038302474,0.000031772768,0.0000049534547,0.0002002337,0.00001571893,0.000053106207,0.9957274,0.00048205562,0.0003480755,0.002307953],"study_design_scores_gemma":[0.00006648372,0.000312472,0.0047917264,0.000008328639,0.000012815725,0.0007125564,0.00003912292,0.00067449553,0.986914,0.00017785994,0.006286939,0.0000032719843],"about_ca_topic_score_codex":0.00038513396,"about_ca_topic_score_gemma":0.00077422993,"teacher_disagreement_score":0.005158781,"about_ca_system_score_codex":0.00021750813,"about_ca_system_score_gemma":0.00013130096,"threshold_uncertainty_score":0.01725787},"labels":[],"label_agreement":null},{"id":"W2562656615","doi":"10.1182/blood.v106.11.4639.4639","title":"A Phase I Study of the Histone Deacetylase Inhibitor MGCD0103 (MG-0103) Given as a Three-Times Weekly Oral Dose in Patients with Leukemia or Myelodysplastic Syndromes (MDS).","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Pharmacology; Myelodysplastic syndromes; Nausea; Pharmacodynamics; Pharmacokinetics; Adverse effect; Phases of clinical research; Oncology; Gastroenterology; Clinical trial; Bone marrow","score_opus":0.010143622707078043,"score_gpt":0.2777129898355881,"score_spread":0.2675693671285101,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2562656615","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99509615,0.00069052144,0.00052477093,0.00028242674,0.00007620103,0.0017665803,0.00049020903,0.00006868909,0.0010045388],"genre_scores_gemma":[0.9923226,0.00076577,0.0018764649,0.0006252292,0.00010704247,0.0016377436,0.0011914452,0.000021149071,0.0014525463],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99965,0.0001614083,0.000018460862,0.000054078264,0.000032036096,0.00008396256],"domain_scores_gemma":[0.99940455,0.00009660267,0.00010348211,0.00006145817,0.0000286285,0.00030532578],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00097507396,0.0011000638,0.0013531536,0.00038897854,0.00039339703,0.0007535754,0.0010129123,0.0010106676,0.0022220754],"category_scores_gemma":[0.00067688036,0.0004913245,0.00095664477,0.00043859775,0.0010950826,0.0005527381,0.00031915947,0.0031677387,0.00066748785],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.49124438,0.19712523,0.011333692,0.0007875241,0.0008066646,0.0006885412,0.0006364492,0.003700663,0.16091253,0.0006420683,0.0049731634,0.12714905],"study_design_scores_gemma":[0.3165804,0.6574373,0.012803997,0.000022441995,0.0002099836,0.00032366058,0.00006817242,0.0013949572,0.008660738,0.00015981827,0.0023128332,0.000025694442],"about_ca_topic_score_codex":0.0011784374,"about_ca_topic_score_gemma":0.0024093199,"teacher_disagreement_score":0.0022220754,"about_ca_system_score_codex":0.000857783,"about_ca_system_score_gemma":0.0014049634,"threshold_uncertainty_score":0.0074335337},"labels":[],"label_agreement":null},{"id":"W2563884867","doi":"10.1158/1535-7163.mct-16-0588","title":"Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; National Institutes of Health","keywords":"Epigenetics; Epigenetic therapy; Vorinostat; Histone deacetylase; Biology; DNA methylation; Cancer research; Cancer; Decitabine; Pharmacology; Histone; Gene expression; Genetics; Gene","score_opus":0.013206137043269965,"score_gpt":0.29976905953115307,"score_spread":0.2865629224878831,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2563884867","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9736804,0.010342284,0.0044352054,0.0002752557,0.000065800734,0.0002941129,0.0033136632,0.00032641226,0.007266851],"genre_scores_gemma":[0.9670707,0.00913296,0.011366223,0.00030683182,0.00003384489,0.00022362272,0.005751805,0.000053943102,0.0060599763],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977094,0.00003233194,0.000020861955,0.0000535003,0.000079316706,0.00004299349],"domain_scores_gemma":[0.9998721,0.000022265478,0.00003383586,0.000015184576,0.000027398422,0.000029232328],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021750605,0.00042353393,0.0007004487,0.001095465,0.00019272577,0.000497295,0.00018729815,0.0002793827,0.0019255962],"category_scores_gemma":[0.0002086872,0.00020341417,0.0004432068,0.0009298858,0.00013673105,0.00022180835,0.00026759453,0.0004505627,0.00064557476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028350294,0.00017647039,0.0018312859,0.00028539184,0.00004657956,0.00018628359,0.000022454999,0.0005731067,0.9712276,0.00012215576,0.00044417058,0.024801107],"study_design_scores_gemma":[0.000118888835,0.0022589967,0.015463359,0.000043202854,0.00031121363,0.0007584301,0.00005521357,0.0021046256,0.9573007,0.00008394243,0.021469427,0.000031957632],"about_ca_topic_score_codex":0.00051715196,"about_ca_topic_score_gemma":0.0020793492,"teacher_disagreement_score":0.0019255962,"about_ca_system_score_codex":0.00036588078,"about_ca_system_score_gemma":0.00043312542,"threshold_uncertainty_score":0.0064417124},"labels":[],"label_agreement":null},{"id":"W2565090883","doi":"10.1158/1538-7445.am2015-5341","title":"Abstract 5341: Bifunctional integrated molecules with combined retinoic acid receptor agonist/protein deacetylase inhibitory activities as therapeutic agents for breast cancer and neuroblastoma","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Concordia University; Université de Montréal","funders":"","keywords":"Retinoic acid receptor; Retinoic acid receptor beta; Retinoic acid; Cancer research; Retinoic acid receptor alpha; Retinoic acid receptor gamma; Vorinostat; Pharmacology; Neuroblastoma; Romidepsin; Tretinoin; Biology; Clonogenic assay; Histone deacetylase; Chemistry; Cell culture; Biochemistry; Cell","score_opus":0.044625326493234745,"score_gpt":0.34518043633729645,"score_spread":0.3005551098440617,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2565090883","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95335543,0.018427389,0.013037641,0.00028944484,0.00018897203,0.00028790758,0.0013962575,0.0003603493,0.012656656],"genre_scores_gemma":[0.97453916,0.0060874163,0.010658424,0.00014456075,0.000022268085,0.00013402762,0.0011242589,0.000041810836,0.0072479974],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999001,0.000014717037,0.0000059739073,0.000021950771,0.000035267014,0.000021954958],"domain_scores_gemma":[0.9999716,0.0000032560795,0.000008267706,0.0000029736534,0.0000047770886,0.000009206324],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012661116,0.00036407966,0.00026451662,0.0002505608,0.00008047784,0.0002341193,0.00025874644,0.0002873235,0.0014452746],"category_scores_gemma":[0.00005600758,0.00012871063,0.0002510613,0.00021456406,0.000121766585,0.00015199867,0.0001775246,0.0003734106,0.0005772447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000116267285,0.00005853768,0.00007863266,0.00008200954,0.00001661837,0.00006848279,0.0000128981155,0.00028403118,0.99137163,0.00034193133,0.000166061,0.007402764],"study_design_scores_gemma":[0.00008748869,0.0013951791,0.0013915746,0.000016224514,0.00007164329,0.00032311984,0.000013286591,0.0009660464,0.9767259,0.00005949006,0.01893652,0.000013636716],"about_ca_topic_score_codex":0.00045806414,"about_ca_topic_score_gemma":0.00071429246,"teacher_disagreement_score":0.0014452746,"about_ca_system_score_codex":0.0003569628,"about_ca_system_score_gemma":0.00010813141,"threshold_uncertainty_score":0.0048348904},"labels":[],"label_agreement":null},{"id":"W2569347110","doi":"10.1371/journal.pone.0169338","title":"Differential HDAC1 and 2 Recruitment by Members of the MIER Family","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"HDAC1; Histone deacetylase; Histone deacetylase 2; HEK 293 cells; HDAC4; HDAC11; Cytoplasm; Immunoprecipitation; Cell culture; Biology; HDAC10; Cell biology; Histone deacetylase 5; Chemistry; Molecular biology; Genetics; Gene; Histone","score_opus":0.07174795574654723,"score_gpt":0.29059561395777844,"score_spread":0.2188476582112312,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2569347110","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9881483,0.0045075924,0.0031021785,0.000097694414,0.000036331072,0.000024356985,0.0010095945,0.00007446871,0.00299958],"genre_scores_gemma":[0.98562485,0.0016101855,0.0038046974,0.00012479037,0.000022948356,0.000054458727,0.0030612317,0.00004163594,0.00565524],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997905,0.000022493468,0.000017133912,0.00005987068,0.000047040114,0.00006290726],"domain_scores_gemma":[0.9999285,0.000014339349,0.000013405035,0.000013266031,0.000011136441,0.000019462552],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016881895,0.000258993,0.00029679688,0.00022694077,0.00019992766,0.00037678477,0.00017072231,0.00024605286,0.0018332152],"category_scores_gemma":[0.00016246337,0.00016193104,0.00038063238,0.00018217631,0.00013305487,0.0002585213,0.00025486058,0.0004274179,0.0006953832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000104534294,0.0000070662163,0.000624706,0.000030320853,0.0000056873805,0.000046033507,0.00002065696,0.000014875218,0.99807954,0.000053838336,0.000046044,0.00096662424],"study_design_scores_gemma":[0.000013412372,0.00010212459,0.040048346,0.000005665513,0.000020138235,0.0006828642,0.00006269563,0.0005464378,0.95194596,0.000046018384,0.006519837,0.0000065892486],"about_ca_topic_score_codex":0.00042421866,"about_ca_topic_score_gemma":0.00085575593,"teacher_disagreement_score":0.0018332152,"about_ca_system_score_codex":0.00027422214,"about_ca_system_score_gemma":0.00011308504,"threshold_uncertainty_score":0.0061326623},"labels":[],"label_agreement":null},{"id":"W2569366072","doi":"10.1182/blood.v116.21.1836.1836","title":"Clioquinol Arrests Cell Cycle at G1 Phase and Triggers Intrinsic Apoptosis In Myeloma and Leukemia Cells by Inhibiting Histone Deacetylases","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Clioquinol; Cancer research; Programmed cell death; Apoptosis; Chemistry; Vorinostat; Histone; Histone deacetylase; Pharmacology; Biology; Biochemistry; DNA","score_opus":0.004808900546495452,"score_gpt":0.2552840271920218,"score_spread":0.25047512664552635,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2569366072","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9857729,0.005500068,0.0032478673,0.00025551254,0.000056416302,0.00007206285,0.0021975476,0.00017707514,0.002720555],"genre_scores_gemma":[0.9910836,0.0020109543,0.0013591324,0.00021139321,0.000014829555,0.000063221465,0.002047482,0.000020994476,0.0031882597],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998828,0.0000109339035,0.000008369958,0.000026783046,0.000039892697,0.000031149728],"domain_scores_gemma":[0.9999516,0.000009114595,0.0000107447195,0.0000054398024,0.000013311379,0.000009747816],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007205913,0.00022635817,0.0002904764,0.00022559437,0.00017091758,0.00016463554,0.00017137975,0.00018495345,0.0015862581],"category_scores_gemma":[0.000075388554,0.000102099286,0.00023132464,0.00024331892,0.00014211753,0.0001144443,0.00011496067,0.0004634203,0.0004975823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014947036,0.000020404716,0.00017770234,0.000032931497,0.000002684392,0.000029458603,0.000009663208,0.00004528478,0.9984003,0.000029144292,0.00007223118,0.001030692],"study_design_scores_gemma":[0.00003840946,0.00053535914,0.011782761,0.000006427471,0.000010545833,0.00015026385,0.000038847433,0.00080003083,0.9829448,0.000059197875,0.0036282071,0.000005219844],"about_ca_topic_score_codex":0.0013991299,"about_ca_topic_score_gemma":0.002333569,"teacher_disagreement_score":0.0015862581,"about_ca_system_score_codex":0.00043920608,"about_ca_system_score_gemma":0.00021609318,"threshold_uncertainty_score":0.005306542},"labels":[],"label_agreement":null},{"id":"W2569853665","doi":"10.1371/journal.pone.0169407","title":"HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"Canadian Cancer Society Research Institute; Cancerföreningen i Stockholm; Terry Fox Research Institute","keywords":"Synovial sarcoma; Aggresome; Proteasome; Cancer research; Bortezomib; Cytotoxic T cell; Apoptosis; Biology; Pharmacology; Medicine; Cell biology; Multiple myeloma; Sarcoma; Immunology; Pathology; Autophagy; Biochemistry","score_opus":0.041623203196571416,"score_gpt":0.2796972152557815,"score_spread":0.23807401205921008,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2569853665","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98978186,0.006139169,0.0009450406,0.00009075309,0.000025572148,0.000052137686,0.00023736381,0.000077678334,0.0026503839],"genre_scores_gemma":[0.9953471,0.0027816363,0.00072730175,0.00003222733,0.000008388631,0.000014521675,0.00019874414,0.000005027361,0.0008850241],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998934,0.000019955038,0.000014329168,0.0000141656865,0.00003324351,0.000024900966],"domain_scores_gemma":[0.9999504,0.000011246576,0.00001306912,0.000005402541,0.0000047582953,0.000015079881],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016354218,0.00025602887,0.0004141712,0.00041069445,0.00010821588,0.00028711127,0.00013650426,0.00013071619,0.0010547648],"category_scores_gemma":[0.00011015636,0.00015522091,0.00022526615,0.00028023927,0.00012993242,0.0001675912,0.00014173602,0.0002660065,0.0002426961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00079601194,0.00024911598,0.0017641383,0.0001401629,0.00005809339,0.00017893186,0.000023370578,0.0006767827,0.97323585,0.000203158,0.00027910873,0.02239522],"study_design_scores_gemma":[0.00019846068,0.004820633,0.026718313,0.000014668105,0.00015737097,0.0012729573,0.000050920382,0.0014741461,0.9581972,0.0001386371,0.0069432715,0.000013401583],"about_ca_topic_score_codex":0.00043614453,"about_ca_topic_score_gemma":0.002911961,"teacher_disagreement_score":0.0010547648,"about_ca_system_score_codex":0.00021361161,"about_ca_system_score_gemma":0.00023517909,"threshold_uncertainty_score":0.0035285354},"labels":[],"label_agreement":null},{"id":"W2572038227","doi":"10.1182/blood.v116.21.4626.4626","title":"Effect of Valproic Acid (VPA) on Fludarabine Activity In Chronic Lymphocytic Leukemia (CLL) Patients","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Research Manitoba; CancerCare Manitoba; University of Manitoba","funders":"","keywords":"Apoptosis; Chronic lymphocytic leukemia; Fludarabine; Cancer research; Programmed cell death; Chemistry; Histone deacetylase; Leukemia; Cell culture; Histone deacetylase inhibitor; Histone; Biology; Immunology; Biochemistry; Chemotherapy","score_opus":0.0037017163676691125,"score_gpt":0.25490969922148693,"score_spread":0.2512079828538178,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2572038227","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9955212,0.003227662,0.000030091976,0.00007766979,0.000014514911,0.00001192405,0.00015837113,0.00000681376,0.0009517441],"genre_scores_gemma":[0.9991431,0.00036655928,0.000030660387,0.0000479054,0.000014607702,0.0000056769154,0.0001641714,8.9073563e-7,0.00022634573],"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983907,0.00005153232,0.000021281992,0.000029384864,0.000023728671,0.00003492389],"domain_scores_gemma":[0.99967206,0.00008834416,0.00006786384,0.00000850608,0.000032912558,0.0001304492],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023999214,0.00019655486,0.00034266515,0.00033790708,0.00025372856,0.00032356323,0.00009820058,0.00028587857,0.0009836269],"category_scores_gemma":[0.000588705,0.00007551583,0.0002649965,0.0002689904,0.00011183999,0.00018344562,0.00013997054,0.00030662728,0.00013268036],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.04362994,0.0009851946,0.8326498,0.00030301724,0.00040725508,0.0031719164,0.00045252958,0.00045475463,0.028199408,0.00014123303,0.0012071427,0.0883979],"study_design_scores_gemma":[0.0007347919,0.011159429,0.977385,0.0000610648,0.0003350924,0.0031123555,0.00021531121,0.00027896525,0.0029015031,0.000053295702,0.0037453878,0.000017792778],"about_ca_topic_score_codex":0.0013658513,"about_ca_topic_score_gemma":0.0021079269,"teacher_disagreement_score":0.0013658513,"about_ca_system_score_codex":0.0003526038,"about_ca_system_score_gemma":0.00020089878,"threshold_uncertainty_score":0.003290534},"labels":[],"label_agreement":null},{"id":"W2573399798","doi":"10.1182/blood.v126.23.4228.4228","title":"Ricolinostat (ACY-1215), the First Selective HDAC6 Inhibitor, Combines Safely with Pomalidomide and Dexamethasone and Shows Promosing Early Results in Relapsed-and-Refractory Myeloma (ACE-MM-102 Study)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Calgary; University of Alberta","funders":"","keywords":"Pomalidomide; Medicine; Lenalidomide; Tolerability; Internal medicine; Clinical endpoint; Progressive disease; Dexamethasone; Refractory (planetary science); Neutropenia; Gastroenterology; Phases of clinical research; Population; Urology; Bortezomib; Multiple myeloma; Pharmacology; Oncology; Clinical trial; Adverse effect; Toxicity; Chemotherapy","score_opus":0.01544769349969395,"score_gpt":0.2545100883772734,"score_spread":0.23906239487757946,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2573399798","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96009785,0.015109089,0.0007917815,0.0010504662,0.00017220934,0.0011752222,0.0028608537,0.000256994,0.018485453],"genre_scores_gemma":[0.9834471,0.0042659976,0.0011560727,0.00085271953,0.00012734711,0.00028525124,0.0045778295,0.00003185886,0.005255763],"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9997968,0.00007915577,0.00001158749,0.000037596998,0.000034672066,0.000040266663],"domain_scores_gemma":[0.99975544,0.00003259263,0.000056227705,0.000022131022,0.000016697662,0.00011689783],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008738509,0.0005151962,0.0007988026,0.00028453965,0.0001514739,0.0006796625,0.00048207366,0.0005190072,0.0043434333],"category_scores_gemma":[0.00030747944,0.00019458831,0.00079261576,0.00028183652,0.00031410242,0.00033035612,0.00024370177,0.0016065285,0.0009207429],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.27347976,0.021463081,0.022248955,0.001884469,0.0025805042,0.00070531724,0.00021514714,0.0036102803,0.12936826,0.001358876,0.031576402,0.5115089],"study_design_scores_gemma":[0.4513682,0.29986686,0.08737499,0.0003062137,0.0025136704,0.003467747,0.00012380238,0.004808658,0.071653314,0.0007389229,0.07768694,0.000090665286],"about_ca_topic_score_codex":0.00088898494,"about_ca_topic_score_gemma":0.0037263243,"teacher_disagreement_score":0.0043434333,"about_ca_system_score_codex":0.0009151912,"about_ca_system_score_gemma":0.0008100681,"threshold_uncertainty_score":0.014530182},"labels":[],"label_agreement":null},{"id":"W2575735043","doi":"10.1182/blood.v110.11.444.444","title":"Phase I/II Study of MGCD0103, an Oral Isotype-Selective Histone Deacetylase (HDAC) Inhibitor, in Combination with 5-Azacitidine in Higher-Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML).","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Azacitidine; Medicine; Internal medicine; Myelodysplastic syndromes; Nausea; Phases of clinical research; Histone deacetylase inhibitor; Oncology; Pharmacology; Gastroenterology; Clinical trial; Bone marrow; Histone deacetylase; Biology; DNA methylation","score_opus":0.01101789143580768,"score_gpt":0.28429147623568246,"score_spread":0.2732735847998748,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2575735043","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9816413,0.002713107,0.0013842295,0.00074745546,0.0002487488,0.0073579988,0.001920094,0.00017244971,0.0038145774],"genre_scores_gemma":[0.9734587,0.0029587143,0.004905989,0.0016026392,0.00024735022,0.005845825,0.0041902442,0.000059767943,0.00673084],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99965036,0.00014705583,0.000015541873,0.000069325804,0.000037727896,0.000079942954],"domain_scores_gemma":[0.99952996,0.000051770625,0.000068304515,0.00003883006,0.000032515403,0.00027866208],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011592103,0.0014435023,0.0016082429,0.00060073275,0.0004493315,0.000849257,0.0011780681,0.0015471227,0.0030059286],"category_scores_gemma":[0.00052632956,0.0007132595,0.0010360132,0.00044831878,0.000990506,0.00059962814,0.00034083577,0.0031739213,0.0008066415],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.5238034,0.21950816,0.0051156743,0.000854582,0.0010763162,0.0003890206,0.00031558576,0.0037502323,0.1366097,0.00089147117,0.008476527,0.099209346],"study_design_scores_gemma":[0.39455453,0.580722,0.006236139,0.00003446745,0.00035098544,0.0002607192,0.00005562953,0.0016590283,0.010990117,0.00028109018,0.0048284023,0.00002693015],"about_ca_topic_score_codex":0.0016499857,"about_ca_topic_score_gemma":0.00395189,"teacher_disagreement_score":0.0030059286,"about_ca_system_score_codex":0.0009788506,"about_ca_system_score_gemma":0.0024289836,"threshold_uncertainty_score":0.01005584},"labels":[],"label_agreement":null},{"id":"W2580493818","doi":"10.3324/haematol.2016.154377","title":"Safety and efficacy of abexinostat, a pan-histone deacetylase inhibitor, in non-Hodgkin lymphoma and chronic lymphocytic leukemia: results of a phase II study","year":2017,"lang":"en","type":"article","venue":"Haematologica","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Pharmacyclics; Servier","keywords":"Medicine; Follicular lymphoma; Adverse effect; Internal medicine; Neutropenia; Lymphoma; Histone deacetylase inhibitor; Gastroenterology; Chronic lymphocytic leukemia; Oncology; Pharmacology; Histone deacetylase; Immunology; Leukemia; Chemotherapy; Biology","score_opus":0.01595690113616621,"score_gpt":0.3266580733588823,"score_spread":0.3107011722227161,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2580493818","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930218,0.0033191475,0.0005619421,0.00024344199,0.000042753745,0.0010803507,0.0005835371,0.00004881011,0.0010981584],"genre_scores_gemma":[0.99217176,0.0026319933,0.0007898168,0.00065889,0.000093183575,0.00087748887,0.0016324365,0.000019628413,0.0011247098],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9993979,0.0003202061,0.00004664771,0.000071273964,0.00007045031,0.000093578295],"domain_scores_gemma":[0.9990747,0.00020787936,0.00021237358,0.000087289794,0.000082995546,0.00033470118],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0025474655,0.00071313314,0.0019149318,0.00029585272,0.000291337,0.00067312253,0.0005650058,0.00085583585,0.0012303699],"category_scores_gemma":[0.00094245706,0.0003438413,0.0010871006,0.00032953796,0.0005987735,0.0006779459,0.00019576913,0.0017255914,0.00035960617],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.47317985,0.09472377,0.03424184,0.001615168,0.0026505126,0.001027436,0.00061904965,0.0030914384,0.11376845,0.00034209708,0.0049824673,0.26975796],"study_design_scores_gemma":[0.25362635,0.6544256,0.07257574,0.000078929595,0.0010283248,0.0009349428,0.00012960788,0.0017148204,0.009667411,0.0002472241,0.0055269734,0.000044075798],"about_ca_topic_score_codex":0.0006444148,"about_ca_topic_score_gemma":0.0015758924,"teacher_disagreement_score":0.0025474655,"about_ca_system_score_codex":0.000701283,"about_ca_system_score_gemma":0.0009177317,"threshold_uncertainty_score":0.013472497},"labels":[],"label_agreement":null},{"id":"W2581634238","doi":"","title":"HDAC inhibitors alter retinal degeneration phenotypes and induce autophagy in Xenopus laevis models of retinal degeneration.","year":2016,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Retinal degeneration; Xenopus; Degeneration (medical); Autophagy; Retinal; Phenotype; Retinal regeneration; Biology; Cell biology; Neuroscience; Medicine; Ophthalmology; Genetics; Apoptosis; Gene","score_opus":0.031618227394257,"score_gpt":0.32373884765698074,"score_spread":0.29212062026272373,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2581634238","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9787275,0.007494987,0.0026871774,0.0006383975,0.0001995686,0.00013236068,0.002373428,0.00052079477,0.007225808],"genre_scores_gemma":[0.9799514,0.004715779,0.0027778605,0.0001393784,0.000024856614,0.00012601881,0.0010977493,0.000076713746,0.011090185],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997975,0.000034623023,0.00002776951,0.000034387376,0.0000498952,0.00005577408],"domain_scores_gemma":[0.99984765,0.000016856342,0.000065113636,0.000016242804,0.000014545981,0.000039564216],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024567285,0.00055764086,0.00032924025,0.0009664453,0.00032976866,0.00036185887,0.00031913695,0.00044475988,0.0019617632],"category_scores_gemma":[0.00008951103,0.0002762353,0.00052646676,0.00032217256,0.0003931288,0.00036981888,0.0001704341,0.0009321883,0.0004193326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042045044,0.00011603447,0.00017291014,0.000059903414,0.000022415437,0.000056477005,0.00001932337,0.00008805895,0.99702364,0.00021509494,0.00020667988,0.0015988996],"study_design_scores_gemma":[0.00008436327,0.00064680696,0.00298603,0.000014250551,0.000040223156,0.00013389639,0.000039757993,0.0004135177,0.99365485,0.000066163324,0.0019134992,0.000006709091],"about_ca_topic_score_codex":0.0026944499,"about_ca_topic_score_gemma":0.0077811885,"teacher_disagreement_score":0.0026944499,"about_ca_system_score_codex":0.00079518376,"about_ca_system_score_gemma":0.00038008866,"threshold_uncertainty_score":0.0065627694},"labels":[],"label_agreement":null},{"id":"W2583128854","doi":"10.1111/dom.12896","title":"Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice","year":2017,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"National Health and Medical Research Council; Deakin University","keywords":"Skeletal muscle; Endocrinology; Internal medicine; Corepressor; Insulin; Cardiac function curve; Cardiac muscle; Glucose uptake; Beta oxidation; In vivo; Medicine; Metabolism; Biology; Gene expression; Heart failure; Biochemistry; Gene","score_opus":0.011553266496461776,"score_gpt":0.2606076476147208,"score_spread":0.24905438111825906,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2583128854","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99287075,0.0023327132,0.0017803422,0.00015932499,0.00007899233,0.00006435305,0.00089414994,0.000186791,0.0016326949],"genre_scores_gemma":[0.98481166,0.0033421027,0.0033662568,0.00017543626,0.000047657715,0.000114401264,0.0017128602,0.000057617905,0.006371879],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987507,0.00001814919,0.000017125267,0.000027671256,0.000031906,0.00002997434],"domain_scores_gemma":[0.99984443,0.000010272429,0.0000621504,0.000012262147,0.000012818795,0.000058061843],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018625843,0.00077657006,0.0004492752,0.00044971312,0.00016446703,0.00026849052,0.00028906824,0.0003541837,0.002326102],"category_scores_gemma":[0.00011101621,0.00017878726,0.00027903903,0.00026327747,0.0002858606,0.00030991036,0.00020036868,0.0007827612,0.00034048728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011957047,0.00015724519,0.00015576636,0.00006549818,0.000013351482,0.000032590026,0.000009549538,0.000054836273,0.996024,0.000047273625,0.000046964553,0.0021972354],"study_design_scores_gemma":[0.00028579193,0.0053876736,0.00864851,0.000020782041,0.000091436545,0.0001701241,0.00004908366,0.0005617196,0.98213744,0.000047796944,0.0025887669,0.000010822355],"about_ca_topic_score_codex":0.00051430735,"about_ca_topic_score_gemma":0.0013404066,"teacher_disagreement_score":0.002326102,"about_ca_system_score_codex":0.00021270069,"about_ca_system_score_gemma":0.00020993133,"threshold_uncertainty_score":0.007781565},"labels":[],"label_agreement":null},{"id":"W2583383492","doi":"10.1182/blood.v108.11.1954.1954","title":"Phase I/II Study of the Oral Isotype-Selective Histone Deacetylase (HDAC) Inhibitor MGCD0103 in Combination with Azacitidine in Patients (pts) with High-Risk Myelodysplastic Syndrome (MDS) or Acute Myelogenous Leukemia (AML).","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Azacitidine; Medicine; Internal medicine; Myelodysplastic syndromes; Leukemia; Gastroenterology; Oncology; Pharmacology; Bone marrow; DNA methylation; Biology","score_opus":0.004730626248085849,"score_gpt":0.23500564337710644,"score_spread":0.2302750171290206,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2583383492","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98961055,0.001955746,0.00080900424,0.00039414637,0.00015885454,0.004138185,0.000955089,0.000106966574,0.001871333],"genre_scores_gemma":[0.98459727,0.002170417,0.0027631002,0.00087243656,0.00023550856,0.0040552206,0.001969016,0.000045772907,0.0032914078],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9996338,0.0001519922,0.00001742776,0.000073982446,0.00003632974,0.000086519656],"domain_scores_gemma":[0.9995459,0.000053574786,0.000059421956,0.000044174318,0.00002656749,0.000270366],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010934778,0.0015478816,0.002254245,0.0005319387,0.00047042355,0.000890519,0.0010706267,0.0012408001,0.0031170037],"category_scores_gemma":[0.00056651596,0.00067684357,0.0011828656,0.0005179585,0.0010965733,0.0006869694,0.00044820536,0.0032432124,0.0009999983],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.60644597,0.18173513,0.007887505,0.0008724267,0.0010435891,0.00052201503,0.0004231303,0.0031378411,0.089396276,0.00052617094,0.0045321803,0.103477746],"study_design_scores_gemma":[0.33411828,0.64849454,0.007508525,0.000023204513,0.0003122522,0.00024872267,0.000060280876,0.0009181543,0.0054290243,0.00017289472,0.0026894927,0.00002465749],"about_ca_topic_score_codex":0.0011308613,"about_ca_topic_score_gemma":0.0021002637,"teacher_disagreement_score":0.0031170037,"about_ca_system_score_codex":0.00076115027,"about_ca_system_score_gemma":0.0017673319,"threshold_uncertainty_score":0.010427415},"labels":[],"label_agreement":null},{"id":"W2591383443","doi":"10.1186/s12885-017-3126-7","title":"Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma","year":2017,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University; University of Toronto; Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; Hospital for Sick Children; Rally Foundation","keywords":"Neuroblastoma; Cancer research; Homeobox protein NANOG; SOX2; Apoptosis; Histone deacetylase; Stem cell; Cyclin D1; Cancer stem cell; Biology; Cell culture; Cell cycle; Chemistry; Induced pluripotent stem cell; Cell biology; Embryonic stem cell; Biochemistry; Histone","score_opus":0.014633232764713521,"score_gpt":0.30164989185831936,"score_spread":0.28701665909360585,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2591383443","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99692863,0.001170559,0.00022959495,0.00003892221,0.000017273454,0.000027212225,0.00024222831,0.00003219498,0.0013134349],"genre_scores_gemma":[0.99672467,0.001300065,0.00037339955,0.00002044275,0.000010975712,0.000024193347,0.00044040204,0.000006560038,0.0010994885],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994063,0.000011319463,0.0000066763178,0.000007830145,0.000017768285,0.000015834607],"domain_scores_gemma":[0.99994624,0.000013391703,0.000011063566,0.0000046412997,0.000007882778,0.00001677026],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009574485,0.00032744755,0.00027406742,0.00023104096,0.000098515346,0.0001585104,0.00021371285,0.00011662404,0.0014808056],"category_scores_gemma":[0.00010097768,0.000087647306,0.000184973,0.00017469235,0.00016303507,0.00010983509,0.00010634781,0.0003457021,0.00019251512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00091279973,0.0002283004,0.00071073964,0.00013286897,0.000020054818,0.00006641095,0.000027477565,0.00033598652,0.99248236,0.000056105142,0.00016267356,0.0048642065],"study_design_scores_gemma":[0.00014702773,0.0052294047,0.011131168,0.000013541412,0.00007811071,0.00021056693,0.000046801728,0.0009456775,0.9796626,0.000020184094,0.0025081604,0.0000067478186],"about_ca_topic_score_codex":0.0032066677,"about_ca_topic_score_gemma":0.008154432,"teacher_disagreement_score":0.0032066677,"about_ca_system_score_codex":0.00029185103,"about_ca_system_score_gemma":0.00031531425,"threshold_uncertainty_score":0.006376028},"labels":[],"label_agreement":null},{"id":"W2591539479","doi":"10.1200/jco.2012.30.5_suppl.16","title":"Impact of 36 months of androgen-deprivation therapy (ADT) on physical function and quality of life (QOL) in men with nonmetastatic prostate cancer.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Androgen deprivation therapy; Prostate cancer; Grip strength; Quality of life (healthcare); Analysis of variance; Internal medicine; Physical therapy; Cancer","score_opus":0.09242753582723225,"score_gpt":0.4768567205650392,"score_spread":0.38442918473780696,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2591539479","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9982364,0.0012637699,0.000020708912,0.000046669054,0.000008556548,0.000010141635,0.00014380786,0.0000031102215,0.00026669845],"genre_scores_gemma":[0.9995726,0.00015942942,0.000025074318,0.000019814828,0.000007736935,0.000004054767,0.00012657138,4.1346038e-7,0.00008427701],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99961984,0.00015283923,0.000028797116,0.000050885883,0.00007824785,0.000069226575],"domain_scores_gemma":[0.99921346,0.00015074799,0.00029016114,0.000024484112,0.000041835498,0.00027933763],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007074108,0.00024939037,0.00035271308,0.00028633766,0.0002705496,0.0004067619,0.00018827667,0.00025126175,0.00083511573],"category_scores_gemma":[0.0013771619,0.00011272931,0.0006662497,0.00029059965,0.0002449791,0.00023567921,0.00040795715,0.00030775715,0.00010360397],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0064553595,0.0007777665,0.9691868,0.00008200355,0.00042644417,0.0001532842,0.00016611382,0.00032213586,0.000540656,0.000016380965,0.00024860035,0.021624364],"study_design_scores_gemma":[0.0000762303,0.0031473387,0.99606824,0.0000067252195,0.00008446782,0.00012436835,0.000052437663,0.000179107,0.00007508985,0.00001152307,0.00017012696,0.000004178604],"about_ca_topic_score_codex":0.0039047976,"about_ca_topic_score_gemma":0.006781223,"teacher_disagreement_score":0.0039047976,"about_ca_system_score_codex":0.00036819893,"about_ca_system_score_gemma":0.00026768362,"threshold_uncertainty_score":0.007764101},"labels":[],"label_agreement":null},{"id":"W2592898871","doi":"10.1182/blood.v128.22.4162.4162","title":"A Phase I Study of Romidepsin, Gemcitabine, Dexamethasone and Cisplatin Combination Therapy in the Treatment of Peripheral T-Cell and Diffuse Large B-Cell Lymphoma: Canadian Cancer Trials Group Study LY.15","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Canadian Partnership Against Cancer; Queen's University; Queen Elizabeth II Health Sciences Centre; Sunnybrook Health Science Centre; University of British Columbia; Princess Margaret Cancer Centre; BC Cancer Agency; Health Sciences Centre; Saint John Regional Hospital; Dalhousie University; University of New Brunswick","funders":"","keywords":"Romidepsin; Gemcitabine; Medicine; Internal medicine; Oncology; Regimen; Diffuse large B-cell lymphoma; Chemotherapy regimen; Lymphoma; Cancer; Histone deacetylase","score_opus":0.02472410259735151,"score_gpt":0.3165873725998048,"score_spread":0.29186327000245327,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2592898871","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9824531,0.004612085,0.00045892788,0.0007927396,0.00013274724,0.0060264296,0.0024245318,0.00010655479,0.0029929667],"genre_scores_gemma":[0.9817779,0.003864048,0.002086426,0.0008877463,0.00013874813,0.0037963968,0.0036458964,0.000026612495,0.0037760644],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9994134,0.00024816048,0.000020119574,0.000077587436,0.000081890386,0.00015893999],"domain_scores_gemma":[0.999253,0.000055558263,0.00009074125,0.000046709054,0.00006275005,0.000491167],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021697227,0.001678352,0.002497848,0.0005182961,0.00069885585,0.00094073993,0.0012871805,0.0011284981,0.0037402182],"category_scores_gemma":[0.00075586647,0.0006581954,0.0012570819,0.00082434854,0.001438595,0.00053619355,0.00041854344,0.0029122892,0.00069539447],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.8561331,0.040832613,0.0063777734,0.0011558594,0.0015726886,0.00029190484,0.000338347,0.0018477408,0.020210948,0.00028760135,0.0055565443,0.06539472],"study_design_scores_gemma":[0.7334445,0.24278605,0.01673503,0.00004336369,0.0007177823,0.00020623502,0.00006215793,0.0006541256,0.0012902688,0.00011483679,0.003912319,0.00003342846],"about_ca_topic_score_codex":0.046574738,"about_ca_topic_score_gemma":0.12507246,"teacher_disagreement_score":0.046574738,"about_ca_system_score_codex":0.004500584,"about_ca_system_score_gemma":0.008363095,"threshold_uncertainty_score":0.09260732},"labels":[],"label_agreement":null},{"id":"W2595933696","doi":"10.1200/jco.2013.31.15_suppl.6045","title":"A phase II study of suberoylanilide hydroxamic acid (SAHA) in subjects with locally advanced, recurrent, or metastatic adenoid cystic carcinoma (ACC).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Gastroenterology; Phases of clinical research; Adenoid cystic carcinoma; Clinical endpoint; Chemotherapy; Progression-free survival; Surgery; Carcinoma; Clinical trial","score_opus":0.06270060775462792,"score_gpt":0.43513113785035357,"score_spread":0.37243053009572563,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2595933696","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99152124,0.0015460025,0.0006350878,0.00031097894,0.00010569392,0.0042008334,0.0004816509,0.00006804111,0.0011305059],"genre_scores_gemma":[0.986837,0.001528531,0.0019880573,0.00090188836,0.00025692812,0.004937091,0.001208099,0.0000251667,0.0023173112],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99948835,0.0002832954,0.000023949542,0.00008253775,0.000032087937,0.000089820336],"domain_scores_gemma":[0.999283,0.000119576594,0.000094461975,0.00005084298,0.000046777946,0.00040530786],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017058345,0.001294841,0.0020016371,0.0005629513,0.0005227689,0.00059408625,0.00058921636,0.0010970911,0.004199405],"category_scores_gemma":[0.0007430611,0.00057721743,0.0008971064,0.0004046072,0.0009503188,0.00071117445,0.00036543372,0.0019170648,0.0011062557],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.70846385,0.13951829,0.010388701,0.00070400606,0.0010123166,0.00032005797,0.0005091262,0.0014012922,0.058912113,0.00025659686,0.0022781112,0.076235645],"study_design_scores_gemma":[0.47565308,0.5107422,0.009306851,0.000015468186,0.00022249963,0.00012635047,0.000053489282,0.00053095736,0.0018121494,0.00012239686,0.0013990616,0.000015505315],"about_ca_topic_score_codex":0.00076646765,"about_ca_topic_score_gemma":0.0018873914,"teacher_disagreement_score":0.004199405,"about_ca_system_score_codex":0.0004659522,"about_ca_system_score_gemma":0.0013332792,"threshold_uncertainty_score":0.014048457},"labels":[],"label_agreement":null},{"id":"W2598945839","doi":"10.1200/jco.2006.24.18_suppl.3007","title":"Phase I study of isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 given as three-times weekly oral dose in patients (pts) with advanced solid tumors","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Tolerability; Nausea; Pharmacokinetics; Internal medicine; Gastroenterology; Vomiting; Pharmacodynamics; Cancer; Leukocytopenia; Pharmacology; Adverse effect; Oncology; Chemotherapy","score_opus":0.028592920474669412,"score_gpt":0.425812251157462,"score_spread":0.3972193306827926,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2598945839","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99537766,0.0011478488,0.00043107203,0.00018552912,0.000055095083,0.0012532028,0.00045358893,0.0001073279,0.0009886336],"genre_scores_gemma":[0.99326044,0.0010436234,0.0015284417,0.00042119762,0.0001032906,0.00103558,0.0012324544,0.000028247425,0.0013467235],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99983764,0.000052758674,0.000009366998,0.00003048384,0.000019610145,0.00005006341],"domain_scores_gemma":[0.9997011,0.0000387924,0.000051814408,0.000024390554,0.000017638602,0.00016622899],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00065582694,0.00096509675,0.0015273911,0.00037708462,0.0003495464,0.00061311125,0.000678569,0.0007464336,0.002304202],"category_scores_gemma":[0.00038365755,0.00037008853,0.0006460019,0.00048061874,0.00071228476,0.00037434354,0.0002937319,0.0023966932,0.00068246515],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.48607138,0.12717853,0.015115645,0.0011279708,0.0010092163,0.000723344,0.00063037145,0.005642388,0.19136296,0.0004598692,0.007077633,0.16360076],"study_design_scores_gemma":[0.29586157,0.667693,0.015702955,0.000029858624,0.00033624444,0.0005733246,0.00006203991,0.0018655208,0.014505274,0.00016527937,0.003179768,0.00002520785],"about_ca_topic_score_codex":0.0012792953,"about_ca_topic_score_gemma":0.0020212412,"teacher_disagreement_score":0.002304202,"about_ca_system_score_codex":0.00073034776,"about_ca_system_score_gemma":0.0013975878,"threshold_uncertainty_score":0.007708311},"labels":[],"label_agreement":null},{"id":"W2601555696","doi":"10.1200/jco.2013.31.15_suppl.8535","title":"A phase II study of single agent mocetinostat, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in patients with diffuse large cell B-cell (DLBCL) and follicular (FL) lymphomas.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Charles-Le Moyne; Ottawa Hospital; Jewish General Hospital; Pyrogenesis (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacodynamics; Internal medicine; Pharmacokinetics; Diffuse large B-cell lymphoma; Gastroenterology; Lymphoma; Follicular lymphoma; Phases of clinical research; Chemotherapy","score_opus":0.030448706834186188,"score_gpt":0.37551820467313407,"score_spread":0.34506949783894786,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2601555696","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99435645,0.0014879251,0.0004379722,0.00028172365,0.00008250094,0.0018559764,0.00049155054,0.00004518777,0.0009606629],"genre_scores_gemma":[0.99202675,0.0014055156,0.0012084643,0.0007114731,0.00014325714,0.0018073366,0.0013502513,0.000015971013,0.0013310207],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99959964,0.0001688903,0.000022753227,0.00007864119,0.00003516797,0.000094916395],"domain_scores_gemma":[0.99914694,0.0001384841,0.00012619708,0.000052613737,0.00004487661,0.0004908444],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014501143,0.0011311355,0.0019458679,0.00039922906,0.00034942076,0.0009513896,0.0007639341,0.0010200196,0.003249588],"category_scores_gemma":[0.00087750127,0.0007036354,0.0009179276,0.00040771766,0.000991906,0.00096373004,0.00034957821,0.0025952908,0.0007859048],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.7189383,0.1202514,0.015260388,0.000903233,0.0012231666,0.0006338765,0.0006041513,0.0026748579,0.047092777,0.00034426837,0.0031718996,0.08890165],"study_design_scores_gemma":[0.5813953,0.40076217,0.011883972,0.00002426766,0.00028750245,0.00037491883,0.000092242255,0.0011066016,0.0020421315,0.000148345,0.0018599465,0.000022617704],"about_ca_topic_score_codex":0.00082738465,"about_ca_topic_score_gemma":0.0019862053,"teacher_disagreement_score":0.003249588,"about_ca_system_score_codex":0.00080652075,"about_ca_system_score_gemma":0.0014767211,"threshold_uncertainty_score":0.0108709335},"labels":[],"label_agreement":null},{"id":"W2601984321","doi":"10.18632/oncotarget.16464","title":"A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health; National Center for Advancing Translational Sciences; Adenoid Cystic Carcinoma Research Foundation","keywords":"Vorinostat; Medicine; Adenoid cystic carcinoma; Internal medicine; Panobinostat; Adverse effect; Progressive disease; Oncology; Histone deacetylase inhibitor; Phases of clinical research; Gastroenterology; Histone deacetylase; Carcinoma; Clinical trial; Disease; Histone; Biology","score_opus":0.031246081343370723,"score_gpt":0.3728440966919328,"score_spread":0.3415980153485621,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2601984321","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.985959,0.004650851,0.00044571055,0.000904137,0.00025742323,0.003204726,0.00077671936,0.00006265277,0.003738755],"genre_scores_gemma":[0.9768545,0.007625691,0.0017316776,0.0016770058,0.00025846483,0.003689237,0.0023435696,0.000046988403,0.005772754],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99974626,0.00011359017,0.000012112852,0.00004150158,0.000034731966,0.000051850664],"domain_scores_gemma":[0.99967754,0.00006207374,0.000035724497,0.000030555824,0.000024065263,0.00017002894],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010663368,0.0008489633,0.001710879,0.00035928012,0.0004035042,0.0008765866,0.0005311934,0.0008591191,0.003618473],"category_scores_gemma":[0.00072701945,0.00037544844,0.0010945873,0.00030758642,0.0006213037,0.00060856383,0.00031834748,0.0020744107,0.00072211627],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.46643853,0.12673242,0.008696675,0.0016262201,0.0015656367,0.0015664871,0.00060884753,0.003787885,0.116394535,0.0007889133,0.011450484,0.26034328],"study_design_scores_gemma":[0.47825927,0.49295712,0.0122754695,0.000071360075,0.00046520945,0.0006840282,0.0001589601,0.0015762834,0.005211204,0.00034815405,0.00794986,0.000043035117],"about_ca_topic_score_codex":0.001571859,"about_ca_topic_score_gemma":0.0041295947,"teacher_disagreement_score":0.003618473,"about_ca_system_score_codex":0.00068261736,"about_ca_system_score_gemma":0.0015355685,"threshold_uncertainty_score":0.012104988},"labels":[],"label_agreement":null},{"id":"W2602728909","doi":"10.1200/jco.2013.31.15_suppl.7116","title":"A phase II study of mocetinostat, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in patients with myelodysplastic syndrome (MDS).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Medicine; Azacitidine; Decitabine; Myelodysplastic syndromes; Lenalidomide; Internal medicine; Pharmacodynamics; Cytarabine; Gastroenterology; Phases of clinical research; Oncology; Bone marrow; Pharmacokinetics; Leukemia; Multiple myeloma; Clinical trial","score_opus":0.029897635690092076,"score_gpt":0.39435186092958446,"score_spread":0.3644542252394924,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2602728909","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993566,0.0016579594,0.00042633837,0.00040221537,0.00013488649,0.0020289454,0.0005926047,0.00005594252,0.0011351245],"genre_scores_gemma":[0.9895404,0.0018815317,0.0013990639,0.00080818124,0.000244982,0.0021838152,0.0017078794,0.00002343095,0.002210748],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99951637,0.00023248955,0.000024961584,0.00009102521,0.000037918326,0.00009737847],"domain_scores_gemma":[0.9991898,0.00013513633,0.00013021131,0.000059408943,0.00004111129,0.00044435688],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015403082,0.001725832,0.002315202,0.0004972078,0.00044338198,0.0011351065,0.0010147381,0.0013770654,0.0033936196],"category_scores_gemma":[0.00098853,0.0009287436,0.001244921,0.0004437909,0.0013529692,0.0011073126,0.00041701036,0.0038021852,0.0008389825],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.728948,0.14189379,0.008225149,0.0008808942,0.0012975279,0.0005895877,0.0004947879,0.0022543345,0.040777214,0.00033827237,0.0032806315,0.07101985],"study_design_scores_gemma":[0.5868477,0.40028065,0.0076383385,0.000025878302,0.00029221352,0.00026992208,0.00006644257,0.00084523426,0.0019175595,0.00012272292,0.0016696836,0.000023624654],"about_ca_topic_score_codex":0.0009579609,"about_ca_topic_score_gemma":0.0022067367,"teacher_disagreement_score":0.0033936196,"about_ca_system_score_codex":0.0009010784,"about_ca_system_score_gemma":0.0015449323,"threshold_uncertainty_score":0.0113527775},"labels":[],"label_agreement":null},{"id":"W2603366817","doi":"10.1200/jco.2007.25.18_suppl.18511","title":"Oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in relapsed diffuse large B-cell lymphoma (DLBCL): Final results of a phase II trial","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Vorinostat; Gastroenterology; Internal medicine; Diffuse large B-cell lymphoma; Clinical endpoint; Phases of clinical research; Refractory (planetary science); Progressive disease; Nausea; Surgery; Toxicity; Lymphoma; Clinical trial; Chemotherapy; Histone deacetylase","score_opus":0.07936872297622341,"score_gpt":0.4543974365386984,"score_spread":0.375028713562475,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2603366817","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9867163,0.0062427176,0.00066909526,0.0006594674,0.0001378956,0.0018033771,0.0011927544,0.00013060737,0.0024477409],"genre_scores_gemma":[0.98675424,0.003690423,0.0013276207,0.0013159607,0.00018343674,0.0015924219,0.0030472702,0.000025180745,0.0020634755],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99967265,0.00017069782,0.000019940815,0.000037990936,0.000029035748,0.0000696855],"domain_scores_gemma":[0.9995165,0.00009331828,0.00008543553,0.000032097625,0.000035489044,0.00023720531],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016636051,0.0009775306,0.0013310233,0.00021636595,0.00027303802,0.0007755536,0.00059659086,0.0007708189,0.0027158353],"category_scores_gemma":[0.0006057428,0.00029735544,0.0009151947,0.00026031322,0.0005273025,0.0004384502,0.00021738872,0.0017747452,0.00079194305],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.73729855,0.043108493,0.008068059,0.0017750685,0.0019357237,0.0004444164,0.00037839406,0.0024344195,0.032327555,0.00040505786,0.010998373,0.16082595],"study_design_scores_gemma":[0.78966,0.19125204,0.01105445,0.000077910656,0.0005991569,0.00027404,0.000060497063,0.0012105508,0.0018146741,0.00018902945,0.0037853152,0.00002241829],"about_ca_topic_score_codex":0.00089292316,"about_ca_topic_score_gemma":0.0025319878,"teacher_disagreement_score":0.0027158353,"about_ca_system_score_codex":0.0008063333,"about_ca_system_score_gemma":0.0010468564,"threshold_uncertainty_score":0.009085357},"labels":[],"label_agreement":null},{"id":"W2605250739","doi":"10.1021/acsmedchemlett.7b00012","title":"Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors","year":2017,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University Health Network","funders":"Canadian Institutes of Health Research; Ontario Brain Institute; National Institute of Neurological Disorders and Stroke; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Prodrug; HDAC6; Acetylation; Chemistry; In vivo; Pharmacology; Histone deacetylase; Biochemistry; Histone; Biology; Gene","score_opus":0.010976174027977957,"score_gpt":0.2773365986402645,"score_spread":0.26636042461228654,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2605250739","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95150423,0.009784629,0.028226605,0.00025741084,0.00012298413,0.00056950515,0.00078319403,0.00018738289,0.008564101],"genre_scores_gemma":[0.9648687,0.0073080314,0.021817347,0.00012099463,0.000040311872,0.00022151874,0.00075212755,0.000022722881,0.0048482716],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999304,0.000010694807,0.000008155571,0.000012525146,0.000017645678,0.000020689151],"domain_scores_gemma":[0.9999442,0.0000057621933,0.000016998909,0.0000055170117,0.000013523764,0.0000139873355],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676951,0.0004302701,0.00028383275,0.00018343968,0.000106597974,0.00016384592,0.00036347122,0.00028553643,0.0011916126],"category_scores_gemma":[0.00011062426,0.00017560387,0.00023898359,0.00016246756,0.00012170227,0.00020193544,0.00017820418,0.00037650488,0.00041925267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015496189,0.00009867992,0.00014070017,0.00020751724,0.000017102073,0.00022240197,0.00004504688,0.0011906426,0.985558,0.000858846,0.00017279042,0.011333228],"study_design_scores_gemma":[0.000092005954,0.0014496726,0.0006888382,0.000013016282,0.000026692807,0.00028609482,0.000017270237,0.0009865208,0.98628205,0.00011342717,0.010031961,0.000012390055],"about_ca_topic_score_codex":0.00027160405,"about_ca_topic_score_gemma":0.00087493565,"teacher_disagreement_score":0.0011916126,"about_ca_system_score_codex":0.00020835815,"about_ca_system_score_gemma":0.00020675457,"threshold_uncertainty_score":0.0039863586},"labels":[],"label_agreement":null},{"id":"W2606139221","doi":"10.1111/cas.13255","title":"Antitumor activity and pharmacologic characterization of the depsipeptide analog as a novel histone deacetylase/ phosphatidylinositol 3‐kinase dual inhibitor","year":2017,"lang":"en","type":"article","venue":"Cancer Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Depsipeptide; Romidepsin; Histone deacetylase; In vivo; Pharmacology; Histone deacetylase inhibitor; Chemistry; Cancer research; Medicine; Biology; Biochemistry; Histone","score_opus":0.019012677191405713,"score_gpt":0.3463812021487718,"score_spread":0.3273685249573661,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2606139221","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99078935,0.0031058916,0.0022099349,0.00012358661,0.000030623192,0.0001085934,0.00077822944,0.000043223816,0.002810575],"genre_scores_gemma":[0.9929911,0.0021802268,0.002100869,0.00006492461,0.000015816919,0.000060966253,0.0008992459,0.000008094131,0.0016787577],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999536,0.0000073286187,0.0000048891525,0.000009039286,0.000009168595,0.00001598347],"domain_scores_gemma":[0.9999697,0.0000045821575,0.0000060159623,0.0000036046738,0.0000045278416,0.000011624339],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000086832544,0.0002730851,0.0002465441,0.00018010681,0.00008517211,0.00015007719,0.0001527545,0.00014300791,0.00069549686],"category_scores_gemma":[0.000048648333,0.00007251553,0.000185186,0.00012424539,0.00010575541,0.000121229255,0.00006060931,0.00039659842,0.00023931396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019397,0.00016836585,0.00016501395,0.000063715444,0.000009043885,0.000076742486,0.000012070784,0.00039220517,0.9940599,0.00009847111,0.00009047892,0.00466999],"study_design_scores_gemma":[0.0001024749,0.0047900965,0.004599113,0.000006255673,0.000051503543,0.00046253705,0.000017009159,0.0017922497,0.9834394,0.00003628738,0.0046930662,0.000010109347],"about_ca_topic_score_codex":0.000728539,"about_ca_topic_score_gemma":0.0010559467,"teacher_disagreement_score":0.000728539,"about_ca_system_score_codex":0.00020241777,"about_ca_system_score_gemma":0.00016815466,"threshold_uncertainty_score":0.0023266673},"labels":[],"label_agreement":null},{"id":"W2607023270","doi":"10.1021/acsomega.6b00481","title":"Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6","year":2017,"lang":"en","type":"article","venue":"ACS Omega","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Fondation Pierre Mercier; Académie des Sciences, Institut de France; Centre National de la Recherche Scientifique; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche","keywords":"Selectivity; Linker; Chemistry; HDAC6; HDAC1; Gene isoform; Histone deacetylase; Ketone; Biochemistry; Combinatorial chemistry; Histone; Stereochemistry; Gene; Organic chemistry","score_opus":0.02506079298136625,"score_gpt":0.32506882210789795,"score_spread":0.3000080291265317,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2607023270","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9633827,0.0080258455,0.015806993,0.00034167775,0.00008257711,0.000084186206,0.0009857583,0.0003651171,0.010925178],"genre_scores_gemma":[0.9718684,0.005257439,0.014166826,0.0001626237,0.000023866674,0.000041882606,0.00090242823,0.000055078697,0.0075214696],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999503,0.000006208443,0.0000038851035,0.000011801943,0.000014582213,0.000013217575],"domain_scores_gemma":[0.9999685,0.000008511419,0.000006957505,0.000004267563,0.000005812897,0.0000059344297],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012676907,0.000264258,0.00020262458,0.000116940195,0.000077845856,0.00018984119,0.00020668795,0.00015541035,0.003874329],"category_scores_gemma":[0.00005733005,0.00011030709,0.00016095676,0.00012979373,0.00011037506,0.000252351,0.00009121001,0.00043478652,0.0005852464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009339888,0.000014351197,0.00007858968,0.00004158966,0.000005065339,0.000024694438,0.000005449646,0.000117730386,0.99731904,0.00011319915,0.00007511777,0.002111644],"study_design_scores_gemma":[0.00001680128,0.00014757102,0.0009777676,0.0000024270346,0.000008542047,0.00008163095,0.0000073511164,0.0010612364,0.99510765,0.00003312733,0.0025526078,0.0000031729244],"about_ca_topic_score_codex":0.00075310445,"about_ca_topic_score_gemma":0.0013728164,"teacher_disagreement_score":0.003874329,"about_ca_system_score_codex":0.00025217736,"about_ca_system_score_gemma":0.00014584797,"threshold_uncertainty_score":0.012960911},"labels":[],"label_agreement":null},{"id":"W2609884290","doi":"10.1111/bjh.14698","title":"A phase 2 study of mocetinostat, a histone deacetylase inhibitor, in relapsed or refractory lymphoma","year":2017,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Charles-Le Moyne; McGill University; University of Ottawa; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Mirati Therapeutics","keywords":"Medicine; Internal medicine; Histone deacetylase inhibitor; Follicular lymphoma; Oncology; Adverse effect; Diffuse large B-cell lymphoma; Refractory (planetary science); Lymphoma; Aggressive lymphoma; Gastroenterology; Histone deacetylase; Rituximab; Biology; Histone","score_opus":0.022412711113689827,"score_gpt":0.3520875203780766,"score_spread":0.3296748092643868,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2609884290","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9946631,0.0014898104,0.0004180728,0.00023830387,0.00005937376,0.0016665676,0.00038936202,0.000056848756,0.0010184478],"genre_scores_gemma":[0.99048424,0.0019926608,0.0014257156,0.0007873823,0.000104082064,0.0018696941,0.0012299243,0.000020378287,0.0020860452],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99976605,0.00012018422,0.000009382858,0.000037057365,0.000017679258,0.000049709026],"domain_scores_gemma":[0.99974793,0.000045298017,0.000042876054,0.00002121096,0.00001972209,0.00012295184],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009262754,0.0008404944,0.0012185344,0.00038516038,0.00021266642,0.0004933131,0.00040235862,0.000655691,0.0022097742],"category_scores_gemma":[0.0005663551,0.0003835513,0.00073383923,0.00022133513,0.00034870845,0.00039483863,0.00021595127,0.0014515616,0.0004014701],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.49073493,0.106075004,0.013554703,0.0010506257,0.0014608083,0.0010800143,0.00058560696,0.0036564714,0.10301752,0.00047833493,0.0054902574,0.27281573],"study_design_scores_gemma":[0.47461355,0.4947238,0.017377263,0.000044752738,0.0003909873,0.0006905368,0.00008559602,0.001930019,0.0051929834,0.00023433579,0.004677794,0.000038384653],"about_ca_topic_score_codex":0.0006748562,"about_ca_topic_score_gemma":0.0016901658,"teacher_disagreement_score":0.0022097742,"about_ca_system_score_codex":0.00044518636,"about_ca_system_score_gemma":0.00075134216,"threshold_uncertainty_score":0.007392466},"labels":[],"label_agreement":null},{"id":"W2614989544","doi":"10.11606/t.10.2016.tde-05102016-140858","title":"&lt;b&gt;Uso de inibidores das histonas deacetilases na transferência nuclear de células somáticas em bovinos&lt;/b&gt;","year":2016,"lang":"pt","type":"dissertation","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Foreign Affairs and International Trade Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Physics; Molecular biology; Chemistry; Biology","score_opus":0.010646925120866403,"score_gpt":0.2918854926771803,"score_spread":0.2812385675563139,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2614989544","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.926772,0.008311166,0.026134176,0.0015955841,0.0007559011,0.0005118569,0.005000653,0.0011507246,0.029767938],"genre_scores_gemma":[0.84750646,0.0048946543,0.034568835,0.00082826364,0.000063174,0.00065336213,0.0058600814,0.00037989698,0.1052452],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99964666,0.00004813843,0.000030125753,0.00012083029,0.00010093996,0.00005322496],"domain_scores_gemma":[0.9998342,0.00004451783,0.000038347243,0.0000258327,0.000027279122,0.000029785702],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030159153,0.0005439952,0.00039648256,0.0002728842,0.00025775857,0.0004832367,0.00043120855,0.0006248242,0.008151236],"category_scores_gemma":[0.00019318315,0.00022654537,0.000363298,0.00027857488,0.00044992,0.00027561316,0.00028769133,0.0012074594,0.0024817442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016609715,0.00005512844,0.000089248686,0.000054382137,0.000005571121,0.000039474,0.00001959567,0.000040423434,0.9962567,0.000121955214,0.0002503428,0.0029010489],"study_design_scores_gemma":[0.000027753002,0.00080548075,0.0012989738,0.000011101205,0.000019932246,0.00013127674,0.000035734214,0.00044318452,0.9862876,0.000058950718,0.010873655,0.000006283143],"about_ca_topic_score_codex":0.0026543443,"about_ca_topic_score_gemma":0.0041948636,"teacher_disagreement_score":0.008151236,"about_ca_system_score_codex":0.00042230976,"about_ca_system_score_gemma":0.00035526213,"threshold_uncertainty_score":0.027268589},"labels":[],"label_agreement":null},{"id":"W2620973725","doi":"10.1371/journal.pone.0176431","title":"Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis","year":2017,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"Natural Science Foundation of Anhui Province; National Natural Science Foundation of China","keywords":"Internal medicine; Medicine; Odds ratio; Meta-analysis; Confidence interval; Gastroenterology; Metastasis; Oncology; Cancer","score_opus":0.16205035046556485,"score_gpt":0.34163931183415436,"score_spread":0.1795889613685895,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2620973725","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.038424406,0.957029,0.0016930803,0.00043134097,0.00029805116,0.00018320314,0.0014654485,0.000067488516,0.00040797747],"genre_scores_gemma":[0.73708785,0.25479183,0.0031346579,0.0008588008,0.00051961915,0.0009018022,0.0019051048,0.00008053151,0.00071985414],"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","domain_scores_codex":[0.9929208,0.0032492885,0.0015293133,0.0013151333,0.00065360876,0.00033185945],"domain_scores_gemma":[0.9845515,0.011293929,0.0020944322,0.0008127802,0.00092456175,0.00032286625],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.011923226,0.0027680104,0.012891253,0.0043442585,0.00080298487,0.0028777337,0.0020114484,0.0023055759,0.0031397704],"category_scores_gemma":[0.019758461,0.0014082715,0.05246677,0.00630305,0.00056140387,0.0014833297,0.0014689043,0.0021949157,0.00030463564],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0035117117,0.000030109808,0.03344446,0.047308132,0.9093747,0.00015921923,0.00004950364,0.00089558464,0.00030889644,0.00007122993,0.00037416504,0.0044721346],"study_design_scores_gemma":[0.00032638016,0.00017618915,0.012237166,0.002101009,0.9839004,0.000085997875,0.000021390564,0.00044343589,0.00008489017,0.000110973684,0.0004961695,0.000016079892],"about_ca_topic_score_codex":0.0053659244,"about_ca_topic_score_gemma":0.008437991,"teacher_disagreement_score":0.012891253,"about_ca_system_score_codex":0.0012148311,"about_ca_system_score_gemma":0.0016476859,"threshold_uncertainty_score":0.06305677},"labels":[],"label_agreement":null},{"id":"W2694932815","doi":"10.1111/bph.13929","title":"WMJ‐8‐B, a novel hydroxamate derivative, induces MDA‐MB‐231 breast cancer cell death <i>via</i> the SHP‐1‐STAT3‐survivin cascade","year":2017,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"U.S. Food and Drug Administration; Ministry of Science and Technology, Taiwan","keywords":"Survivin; Histone deacetylase; Cancer research; Chromatin immunoprecipitation; Viability assay; Biology; Cell cycle; Apoptosis; Cancer cell; Chemistry; Acetylation; Cell growth; Molecular biology; Cell biology; Histone; Cancer; Promoter; Biochemistry; Gene expression","score_opus":0.019801504040601905,"score_gpt":0.3237200662422061,"score_spread":0.30391856220160424,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2694932815","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9916741,0.004608883,0.0017027834,0.00009859978,0.000035774796,0.000029994048,0.00037029496,0.00008918194,0.0013903214],"genre_scores_gemma":[0.994869,0.0018345598,0.0013118775,0.00004664012,0.000015887674,0.000037080354,0.0005901051,0.000009460979,0.0012855198],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994946,0.000007493285,0.000005448232,0.0000089731975,0.000013134681,0.00001552319],"domain_scores_gemma":[0.99997175,0.0000028484606,0.000011737228,0.000002524612,0.000003313455,0.000007905112],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006944769,0.00031862987,0.0002082769,0.00013303685,0.00010300464,0.00011995859,0.000188825,0.00017111964,0.001255213],"category_scores_gemma":[0.00004108122,0.00010026382,0.00017356731,0.00008951188,0.00013071706,0.00013747283,0.00009133421,0.00038225963,0.00034078624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017494155,0.000038085356,0.00009507906,0.000051937503,0.000004556453,0.000024300218,0.000004395744,0.00004413498,0.99814546,0.00002679982,0.000047224057,0.0013431859],"study_design_scores_gemma":[0.000035628425,0.0008209314,0.0024285554,0.000005356472,0.000016089956,0.00020564233,0.000010344542,0.0002751444,0.9940593,0.000017032282,0.0021229987,0.0000028988186],"about_ca_topic_score_codex":0.00023877219,"about_ca_topic_score_gemma":0.00049018406,"teacher_disagreement_score":0.001255213,"about_ca_system_score_codex":0.00016975516,"about_ca_system_score_gemma":0.00012083962,"threshold_uncertainty_score":0.0041990876},"labels":[],"label_agreement":null},{"id":"W2724797820","doi":"10.1002/jcp.26078","title":"Transcription‐dependent association of HDAC2 with active chromatin","year":2017,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; CancerCare Manitoba Foundation","keywords":"Chromatin; Histone deacetylase 2; Transcription (linguistics); RNA polymerase II; Biology; RNA polymerase; Gene; RNA polymerase II holoenzyme; RNA; Histone; Molecular biology; Cell biology; Genetics; Promoter; Histone deacetylase; Gene expression","score_opus":0.008227171135175355,"score_gpt":0.25602193114510663,"score_spread":0.24779476000993128,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2724797820","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9863138,0.0032722268,0.0056102527,0.00010453555,0.00006142679,0.000023173287,0.0006151467,0.000055887078,0.003943558],"genre_scores_gemma":[0.98776466,0.0006819501,0.0027873814,0.000055483175,0.000024428653,0.000025431838,0.0018094636,0.000025706799,0.006825576],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998332,0.000014587655,0.0000087247545,0.00007651349,0.00003354436,0.000033418906],"domain_scores_gemma":[0.99992514,0.0000100313555,0.0000149045,0.000014337688,0.000015570791,0.000019969986],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010420171,0.00034837367,0.00016288046,0.00016056909,0.00024940036,0.00035647617,0.00025890017,0.00016070832,0.002417028],"category_scores_gemma":[0.00010242967,0.00024139247,0.00034396976,0.0001481721,0.00022866644,0.00017499845,0.00027702944,0.0004460859,0.0006247284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000051309013,0.000005489458,0.0005633618,0.000023981107,0.000008446709,0.00002142477,0.000009259774,0.000014748964,0.9985929,0.00005558737,0.000034611297,0.00061883085],"study_design_scores_gemma":[0.000015088914,0.000097227596,0.032601252,0.0000070293204,0.000020959873,0.00024319616,0.000036156194,0.00082035596,0.96175194,0.000065202235,0.0043364125,0.0000050500576],"about_ca_topic_score_codex":0.0021140247,"about_ca_topic_score_gemma":0.0039688,"teacher_disagreement_score":0.002417028,"about_ca_system_score_codex":0.00043309465,"about_ca_system_score_gemma":0.00019498168,"threshold_uncertainty_score":0.008085787},"labels":[],"label_agreement":null},{"id":"W2725304531","doi":"10.1002/jcp.28353","title":"Protein kinase B/AKT mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells","year":2019,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research","keywords":"Protein kinase B; Phosphorylation; Cell biology; Chemistry; NADPH oxidase; Vascular smooth muscle; Histone deacetylase; Protein kinase A; Histone; Biochemistry; Biology; Endocrinology; Enzyme; Smooth muscle","score_opus":0.00738952449721722,"score_gpt":0.2381055079589185,"score_spread":0.23071598346170127,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2725304531","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9892279,0.004147539,0.0029904745,0.0003411918,0.00020670866,0.000045508874,0.00046353095,0.00011192924,0.0024651797],"genre_scores_gemma":[0.99129194,0.00262585,0.0016196243,0.000105821964,0.000042245043,0.000065429595,0.0011664876,0.000012260604,0.0030703782],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984837,0.000025540843,0.000011262525,0.000025888705,0.000029405322,0.000059545127],"domain_scores_gemma":[0.9999496,0.0000052933347,0.000013022602,0.00000715915,0.000006068456,0.000018908495],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002541971,0.00047095568,0.0002405816,0.00024215154,0.00023638946,0.0002707542,0.00031273268,0.00024258852,0.0019509753],"category_scores_gemma":[0.000106721964,0.000313792,0.00055232336,0.00022278905,0.00021543447,0.00025338237,0.00023119412,0.0008687161,0.0005544757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004936206,0.00014523313,0.00025306558,0.00010201008,0.000016656833,0.00007459125,0.000018554414,0.00007166649,0.9972699,0.00021729381,0.0001543634,0.0011831024],"study_design_scores_gemma":[0.0004080569,0.0011015965,0.03356013,0.00002531766,0.00009142935,0.00044649307,0.00009323556,0.004938216,0.9534416,0.00026492946,0.005612696,0.000016415923],"about_ca_topic_score_codex":0.0018633612,"about_ca_topic_score_gemma":0.0016892265,"teacher_disagreement_score":0.0019509753,"about_ca_system_score_codex":0.00039037922,"about_ca_system_score_gemma":0.0003943547,"threshold_uncertainty_score":0.006526649},"labels":[],"label_agreement":null},{"id":"W2726873973","doi":"10.1186/s12885-017-3430-2","title":"Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex","year":2017,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"HDAC6; Cell biology; Acetylation; Microtubule; Biology; Proximity ligation assay; Downregulation and upregulation; Histone deacetylase; Chemistry; Histone; Genetics","score_opus":0.06334846240452156,"score_gpt":0.3689235725754104,"score_spread":0.30557511017088884,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2726873973","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9839933,0.0051416163,0.0066115116,0.00026703638,0.00010045304,0.000063989726,0.00070198317,0.00016600142,0.0029540774],"genre_scores_gemma":[0.98828566,0.0014410529,0.004295519,0.000068424946,0.00002901414,0.0000780618,0.0017623765,0.000034500325,0.00400542],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999798,0.00002686017,0.00001934874,0.000043594577,0.000057759433,0.000054496544],"domain_scores_gemma":[0.9999285,0.000010051153,0.000020338794,0.000010588834,0.000011141264,0.00001942365],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018660152,0.00034445545,0.00029460134,0.00014269122,0.00023329949,0.00024487425,0.00037544002,0.00019533152,0.0022188502],"category_scores_gemma":[0.000105826424,0.00010334643,0.00035630033,0.00015914133,0.00021042711,0.000121997175,0.0002488512,0.0005280499,0.0007280938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017490114,0.000046182002,0.00019990193,0.000089528716,0.000015235265,0.00003043758,0.000008603,0.00004815376,0.99792445,0.000079549616,0.000109987115,0.0012730847],"study_design_scores_gemma":[0.000024624087,0.00014480691,0.0019510388,0.0000053194494,0.000018396318,0.000093130126,0.00000878395,0.00072758895,0.99365306,0.000017289178,0.003353201,0.0000027716076],"about_ca_topic_score_codex":0.0005190693,"about_ca_topic_score_gemma":0.001053784,"teacher_disagreement_score":0.0022188502,"about_ca_system_score_codex":0.0004259855,"about_ca_system_score_gemma":0.00022367512,"threshold_uncertainty_score":0.007422745},"labels":[],"label_agreement":null},{"id":"W2731206995","doi":"10.1038/s41598-017-04874-4","title":"HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Institutes of Health; Canada Research Chairs","keywords":"HDAC6; Cancer research; Apoptosis; Hypoxia (environmental); Histone deacetylase; Myofibroblast; Medicine; Chemistry; Pharmacology; Cell biology; Histone; Biology; Pathology; Biochemistry","score_opus":0.02516819168591976,"score_gpt":0.30458165120601405,"score_spread":0.2794134595200943,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2731206995","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.4646268,0.47883943,0.026080193,0.0026522758,0.0018994624,0.00030189924,0.004351572,0.0011574747,0.020090776],"genre_scores_gemma":[0.8651612,0.10594101,0.009673136,0.0004940663,0.0005728783,0.000069630834,0.005111694,0.000060226106,0.012916188],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998988,0.00001027385,0.000009465725,0.00002757539,0.000030589672,0.000023319406],"domain_scores_gemma":[0.9999471,0.0000033096467,0.000016436077,0.000004929229,0.000009793981,0.000018466948],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015818956,0.00065790943,0.0004678395,0.00036677622,0.00032301832,0.0005625064,0.0003550534,0.0005202519,0.0019458317],"category_scores_gemma":[0.00009538735,0.00016027997,0.0005072724,0.00044831642,0.00029583438,0.0003241434,0.0002637033,0.000663524,0.0011430042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011381003,0.00016384175,0.004547806,0.0010374164,0.00013383,0.00078750914,0.000053133273,0.0003753649,0.9130612,0.0012212964,0.0028350437,0.07464549],"study_design_scores_gemma":[0.00026581588,0.0013366234,0.028597945,0.00009488737,0.00036423028,0.008881849,0.00008951736,0.0016926001,0.801212,0.0008596721,0.1565599,0.000045011857],"about_ca_topic_score_codex":0.00051158015,"about_ca_topic_score_gemma":0.0009117211,"teacher_disagreement_score":0.0019458317,"about_ca_system_score_codex":0.00046240364,"about_ca_system_score_gemma":0.0002935035,"threshold_uncertainty_score":0.0065094233},"labels":[],"label_agreement":null},{"id":"W2735415569","doi":"10.1038/s41598-017-06243-7","title":"Nucleocytoplasmic Shuttling of Histone Deacetylase 9 Controls Activity-Dependent Thalamocortical Axon Branching","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Axon; HDAC1; Cell biology; Biology; Transfection; Thalamus; Mef2; Mutant; Epigenetics; Chromosomal translocation; Histone; Neuroscience; Chemistry; Histone deacetylase; Molecular biology; Enhancer; Transcription factor; Cell culture; Genetics; Gene","score_opus":0.017364236538805942,"score_gpt":0.33407014303612254,"score_spread":0.3167059064973166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2735415569","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98971903,0.0017927451,0.0061845514,0.00007650354,0.00003921526,0.000010590448,0.00017724038,0.00009953195,0.0019005863],"genre_scores_gemma":[0.9965551,0.0007538517,0.0013465686,0.00002040118,0.0000068671975,0.000011583585,0.00013835519,0.000018585199,0.0011487174],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990284,0.00001152652,0.000007943426,0.00003140101,0.000019520718,0.00002673005],"domain_scores_gemma":[0.99991906,0.000009849418,0.000030042254,0.0000070809283,0.000010547232,0.000023503651],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007906246,0.00025331572,0.00016298595,0.00012932328,0.00013840933,0.00033039897,0.0001991499,0.00016637842,0.00080514094],"category_scores_gemma":[0.000111930785,0.0001498024,0.00018984788,0.00007639471,0.0002962558,0.00025021753,0.00019907167,0.00038598964,0.00027197253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000034158427,0.0000038563594,0.00019524078,0.00000937845,0.0000019019164,0.000018469773,0.000007696644,0.000016545686,0.99898106,0.00009854403,0.0000098563805,0.0006232672],"study_design_scores_gemma":[0.000011086237,0.00007446891,0.009797636,0.000003382672,0.000013374046,0.00008816943,0.000032431453,0.0008927143,0.9877439,0.000084279214,0.0012539856,0.0000045574166],"about_ca_topic_score_codex":0.00091578386,"about_ca_topic_score_gemma":0.0023487739,"teacher_disagreement_score":0.00091578386,"about_ca_system_score_codex":0.0003771939,"about_ca_system_score_gemma":0.00018763347,"threshold_uncertainty_score":0.0027367473},"labels":[],"label_agreement":null},{"id":"W2737725258","doi":"10.1038/cdd.2017.115","title":"Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis","year":2017,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; McGill University; Samuel Waxman Cancer Research Foundation","keywords":"Peroxisome; Vorinostat; Biology; Cell biology; Reactive oxygen species; Histone deacetylase inhibitor; Gene knockdown; Apoptosis; Cancer research; Histone deacetylase; Biochemistry; Histone; Gene","score_opus":0.0115123962709334,"score_gpt":0.24087724605624095,"score_spread":0.22936484978530755,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2737725258","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9901114,0.003508917,0.0019000947,0.00020825145,0.00005485494,0.000035908113,0.000498609,0.00023095454,0.0034510063],"genre_scores_gemma":[0.9931376,0.0015997548,0.0008063023,0.00008602851,0.000013218527,0.000032783446,0.0008557257,0.000019220117,0.0034494926],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991846,0.000013091903,0.000007701767,0.000011594857,0.000025340283,0.00002375621],"domain_scores_gemma":[0.9999528,0.00000800521,0.0000101236665,0.000009538225,0.000007275444,0.000012296994],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008495391,0.00026270052,0.00024869654,0.00030820462,0.00014628127,0.00022449747,0.00015957287,0.00020656364,0.002194567],"category_scores_gemma":[0.00007079842,0.000098399956,0.00018812629,0.00015028828,0.00013495775,0.00016382609,0.00018299856,0.00049997476,0.0005289612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002666038,0.00006410554,0.0001989382,0.00003160802,0.000010464742,0.000032965738,0.000011860685,0.000045435576,0.9961831,0.00006779372,0.00011120793,0.002975819],"study_design_scores_gemma":[0.000048619393,0.0005789452,0.004293135,0.0000059697145,0.00001841701,0.00018598726,0.000037265556,0.00038735822,0.9908885,0.000058423062,0.0034941859,0.0000031957145],"about_ca_topic_score_codex":0.00054856914,"about_ca_topic_score_gemma":0.0010649525,"teacher_disagreement_score":0.002194567,"about_ca_system_score_codex":0.00022812396,"about_ca_system_score_gemma":0.00019598877,"threshold_uncertainty_score":0.007341504},"labels":[],"label_agreement":null},{"id":"W2739066978","doi":"10.1210/en.2017-00159","title":"MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells","year":2017,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; York University","keywords":"MEF2C; Chromatin immunoprecipitation; Transcription factor; AP-1 transcription factor; HDAC4; JUNB; RUNX2; Parathyroid hormone; Promoter; Gene knockdown; Molecular biology; Chemistry; Gene expression; Enhancer; HDAC8; Biology; Internal medicine; Gene; Medicine","score_opus":0.012761519328199184,"score_gpt":0.2890088574456027,"score_spread":0.2762473381174035,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2739066978","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9758446,0.01026052,0.0065680505,0.00037828542,0.00020597033,0.00005710057,0.002195513,0.00013738612,0.0043524653],"genre_scores_gemma":[0.9754583,0.0020716647,0.004521494,0.0003225279,0.00005590223,0.0001840292,0.0044426494,0.000058445134,0.012884929],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996481,0.00003629563,0.000026831514,0.00009744621,0.00011894049,0.000072475494],"domain_scores_gemma":[0.99985373,0.000026837086,0.00002955102,0.000017615723,0.000033913286,0.00003825244],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022217348,0.00038671796,0.00037609972,0.00038047438,0.0004073449,0.0003034362,0.00029822334,0.00038968725,0.0030264074],"category_scores_gemma":[0.00023079128,0.0002482199,0.0005033387,0.00027088486,0.00024347648,0.00020128397,0.00042209224,0.0005473982,0.0009996236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010461077,0.00002117526,0.00028683874,0.00006163031,0.0000065315858,0.00006428063,0.000019430674,0.000020638863,0.9985678,0.000056110108,0.00009482566,0.000696122],"study_design_scores_gemma":[0.000061459956,0.0001344541,0.044719823,0.00003904182,0.000027866137,0.0005493362,0.00007553132,0.0019564736,0.9417685,0.000076542514,0.010573995,0.000017037966],"about_ca_topic_score_codex":0.0018422866,"about_ca_topic_score_gemma":0.0027680274,"teacher_disagreement_score":0.0030264074,"about_ca_system_score_codex":0.0005770934,"about_ca_system_score_gemma":0.00027636942,"threshold_uncertainty_score":0.010124326},"labels":[],"label_agreement":null},{"id":"W2740312400","doi":"10.1158/1538-7445.am2017-1375","title":"Abstract 1375: Loss of C-MYC and chromatin acetylation induce epigenetic reprogramming in acute lymphoblastic leukemia","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Epigenetics; Acetylation; Cancer research; Epigenetic therapy; Epigenome; Chromatin; Histone; Histone H3; Reprogramming; Biology; Cancer cell; Cancer; Molecular biology; Gene expression; Cell biology; Gene; Genetics; DNA methylation","score_opus":0.042099461780625416,"score_gpt":0.3926203307686357,"score_spread":0.35052086898801027,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2740312400","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9943012,0.0010226119,0.001392288,0.00008217347,0.000031412936,0.000048249094,0.0012850184,0.00007058852,0.0017664809],"genre_scores_gemma":[0.99408346,0.0004129686,0.00091145077,0.000067020614,0.000007605038,0.000051425755,0.0020329235,0.000015259639,0.002417993],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998547,0.000025635813,0.000015671156,0.000023707984,0.000039994884,0.000040260125],"domain_scores_gemma":[0.999926,0.00001604266,0.000017820155,0.000010819537,0.0000070866718,0.00002241627],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010853087,0.00021837027,0.00019461021,0.0002371957,0.00010651232,0.00020384305,0.00013601947,0.00017203449,0.0026404795],"category_scores_gemma":[0.00010323917,0.00009345617,0.00022617825,0.0002526187,0.00018248575,0.000096534466,0.00016417388,0.0005242379,0.00054466916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020577986,0.000037526297,0.00025211257,0.000024956358,0.000004350377,0.000051548985,0.00000666203,0.000045523328,0.9981299,0.000057825353,0.0000541715,0.001129659],"study_design_scores_gemma":[0.000038148955,0.00087363314,0.013622208,0.0000054713305,0.000019885596,0.00034514046,0.00003455825,0.0006979736,0.9811064,0.000052464322,0.003200903,0.0000031966015],"about_ca_topic_score_codex":0.00039145545,"about_ca_topic_score_gemma":0.00048358258,"teacher_disagreement_score":0.0026404795,"about_ca_system_score_codex":0.00025639994,"about_ca_system_score_gemma":0.00017603103,"threshold_uncertainty_score":0.008833289},"labels":[],"label_agreement":null},{"id":"W2740491863","doi":"10.1158/1538-7445.am2017-3332","title":"Abstract 3332: Aberrant expression of CSF1R in melanoma is driven through an endogenous viral promoter and it contributes to malignant growth and the acquisition of resistance against BRAF inhibition","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Workplace Health, Safety and Compensation Commission","funders":"","keywords":"Melanoma; Cancer research; Biology; Autocrine signalling; Gene knockdown; Cancer; Carcinogenesis; Metastasis; Oncogene; Cell culture; Cell cycle; Genetics","score_opus":0.04154748017096628,"score_gpt":0.34904840559399275,"score_spread":0.3075009254230265,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2740491863","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9967198,0.00070012413,0.0011183791,0.00006339899,0.000017188488,0.000015067486,0.00047029014,0.000039827453,0.0008557958],"genre_scores_gemma":[0.9964876,0.00023769775,0.00096854096,0.000027306332,0.000006476656,0.000014363733,0.00055007916,0.0000136144,0.0016943405],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999051,0.000011238818,0.000008856449,0.0000204414,0.00003601182,0.000018353105],"domain_scores_gemma":[0.99992025,0.000014111565,0.000025861249,0.000011643135,0.000011686187,0.000016492491],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010014342,0.0001923133,0.00014666996,0.00018208877,0.000109277535,0.00013715295,0.0000699481,0.00019091673,0.0022348047],"category_scores_gemma":[0.00011458179,0.00009158312,0.00016798302,0.00011799928,0.00011818182,0.00007293762,0.00010702852,0.00031431596,0.00046042327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000046976555,0.000007362412,0.0011232721,0.000014390921,0.000002715515,0.00010921896,0.0000064661017,0.0000142901,0.9977875,0.000019294663,0.00003472976,0.0008337807],"study_design_scores_gemma":[0.00001535275,0.00037577818,0.054448396,0.0000102988315,0.000029223758,0.004001353,0.00004521958,0.0011401968,0.935362,0.00007933892,0.0044874484,0.0000053112212],"about_ca_topic_score_codex":0.0005959538,"about_ca_topic_score_gemma":0.0005647482,"teacher_disagreement_score":0.0022348047,"about_ca_system_score_codex":0.00021467802,"about_ca_system_score_gemma":0.0001098774,"threshold_uncertainty_score":0.0074762106},"labels":[],"label_agreement":null},{"id":"W2740875883","doi":"10.1158/1538-7445.am2017-4722","title":"Abstract 4722: Evaluation of the prognostic value of ATG4B expression in different breast cancer subtypes","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Breast cancer; Medicine; Oncology; Tissue microarray; Internal medicine; Proportional hazards model; Cancer; Population; Cohort; Immunohistochemistry; Pathology","score_opus":0.07290922582000203,"score_gpt":0.4351240143499221,"score_spread":0.36221478852992006,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2740875883","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.999215,0.00012508639,0.000075431235,0.000017405797,0.0000018570572,0.000004592002,0.00031860848,0.000004769633,0.00023715118],"genre_scores_gemma":[0.99888843,0.000037461312,0.00014167119,0.000008878464,0.0000046024684,0.000010760085,0.0006122487,0.0000029933185,0.00029295022],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99984753,0.000035462053,0.000013998967,0.000038308528,0.000032611868,0.000032089152],"domain_scores_gemma":[0.99958175,0.00010093832,0.00011663934,0.000037054597,0.00007464491,0.00008900269],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005037366,0.00018174636,0.00031228873,0.0005422956,0.00031134905,0.00043190253,0.00025930925,0.0002734551,0.0023135298],"category_scores_gemma":[0.0007799995,0.00013676469,0.00018413679,0.00054556027,0.0002068155,0.0001321042,0.00019499786,0.00025243813,0.00046505523],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047641477,0.000013529393,0.994645,0.000008958182,0.000034335277,0.00006254132,0.000021225858,0.00005356667,0.0029021027,0.0000058755973,0.00014535485,0.0016310804],"study_design_scores_gemma":[0.000011265129,0.000058446094,0.9984395,0.0000022693348,0.000028940862,0.0003065173,0.000042569205,0.00028039198,0.0006406083,0.000012918761,0.00017479593,0.0000017287305],"about_ca_topic_score_codex":0.005164337,"about_ca_topic_score_gemma":0.006460232,"teacher_disagreement_score":0.005164337,"about_ca_system_score_codex":0.00038260053,"about_ca_system_score_gemma":0.00024866097,"threshold_uncertainty_score":0.010268509},"labels":[],"label_agreement":null},{"id":"W2743743768","doi":"10.1159/000478898","title":"Recurrence of Melanoma after Starting Apremilast for Psoriasis","year":2017,"lang":"en","type":"article","venue":"Case Reports in Dermatology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Apremilast; Melanoma; Psoriasis; Dermatology; Cancer; Metastasis; Sentinel lymph node; Biopsy; Pathology; Internal medicine; Cancer research; Breast cancer","score_opus":0.019426407111900957,"score_gpt":0.32223445368544634,"score_spread":0.3028080465735454,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2743743768","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96733165,0.014715676,0.001651417,0.00229457,0.0004756775,0.00012701903,0.00014459468,0.00015506298,0.01310438],"genre_scores_gemma":[0.9951338,0.0015665604,0.00020844508,0.00090649346,0.00024685054,0.000011001031,0.00009484119,0.000017634002,0.0018143551],"study_design_codex":"case_report","study_design_gemma":"case_report","domain_scores_codex":[0.99967444,0.000046226647,0.00003708391,0.00006810636,0.0000796449,0.000094534495],"domain_scores_gemma":[0.9990139,0.00021848848,0.00028897662,0.000095997646,0.00008739867,0.00029512588],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021231936,0.00040432438,0.000571852,0.0005792094,0.0009269362,0.00060526375,0.00031062975,0.0011763832,0.0019737892],"category_scores_gemma":[0.001503676,0.00025763793,0.0007808644,0.0004003452,0.00026277718,0.0005047878,0.00030518652,0.001961879,0.00065583695],"study_design_candidate":"case_report","study_design_consensus":"case_report","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002566682,0.00025631324,0.052166484,0.00012002132,0.00008762344,0.92076236,0.0005343907,0.00016983606,0.0035836159,0.00018110465,0.0012979573,0.020583633],"study_design_scores_gemma":[0.00003123453,0.0006078977,0.024940398,0.00004015928,0.00006537439,0.969443,0.00016042173,0.00031912187,0.001054627,0.00010233753,0.0032170948,0.000018304414],"about_ca_topic_score_codex":0.0009013883,"about_ca_topic_score_gemma":0.0017304231,"teacher_disagreement_score":0.0019737892,"about_ca_system_score_codex":0.00043554878,"about_ca_system_score_gemma":0.00027259687,"threshold_uncertainty_score":0.006602943},"labels":[],"label_agreement":null},{"id":"W2749486505","doi":"10.1016/j.jsbmb.2017.08.010","title":"Efficacy of hybrid vitamin D receptor agonist/histone deacetylase inhibitors in vitamin D-resistant triple-negative 4T1 breast cancer","year":2017,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Cancer Society Research Institute; Fondation du cancer du sein du Québec; Réseau Québécois de Recherche sur les Médicaments","keywords":"In vivo; Histone deacetylase; Pharmacology; Triple-negative breast cancer; Calcitriol receptor; In vitro; Cancer research; Cytotoxicity; Breast cancer; Cancer cell; Cancer; Biology; Chemistry; Receptor; Medicine; Biochemistry; Internal medicine; Histone","score_opus":0.008343819901832191,"score_gpt":0.3005729459030543,"score_spread":0.2922291260012221,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2749486505","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952803,0.0030127247,0.00020447935,0.00009241903,0.00005552198,0.000038162245,0.0001625253,0.000049711045,0.0011041064],"genre_scores_gemma":[0.99689615,0.0012800752,0.00028129428,0.000043932563,0.000013759125,0.000030202758,0.00028072507,0.000011529722,0.0011623387],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998826,0.000023824965,0.000008545822,0.000020661937,0.000022856419,0.00004142941],"domain_scores_gemma":[0.9998658,0.00003218355,0.000015280124,0.000026918895,0.000010297622,0.000049648832],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002824003,0.00021813347,0.0007438202,0.00027518702,0.0002266694,0.0004712487,0.00039305384,0.00036955738,0.002047366],"category_scores_gemma":[0.00021901815,0.00014704496,0.00040579692,0.0002459105,0.00021632986,0.00022216562,0.00019764883,0.00075506704,0.00029945184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.06086044,0.006911679,0.0050628427,0.00051418494,0.0010557335,0.00043465797,0.00039500062,0.0036430242,0.7079278,0.0010220857,0.001847832,0.21032465],"study_design_scores_gemma":[0.021780169,0.21631052,0.04450561,0.000098181765,0.002494512,0.0027756647,0.000681267,0.007975338,0.66944396,0.0006714032,0.033141058,0.00012237261],"about_ca_topic_score_codex":0.0011230573,"about_ca_topic_score_gemma":0.002732535,"teacher_disagreement_score":0.002047366,"about_ca_system_score_codex":0.000380595,"about_ca_system_score_gemma":0.00034071848,"threshold_uncertainty_score":0.00684911},"labels":[],"label_agreement":null},{"id":"W2750881091","doi":"10.1016/j.jid.2017.07.292","title":"616 Postzygotic mutations of RHOA cause a mosaic neuroectodermal syndrome","year":2017,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"RHOA; Mosaic; Biology; Mutation; Genetics; Gene; Geography","score_opus":0.029018949034802784,"score_gpt":0.3126737459849028,"score_spread":0.2836547969501,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2750881091","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9957777,0.00025792615,0.000770785,0.00008553193,0.000022216998,0.000013805061,0.00010150728,0.000041196257,0.0029293555],"genre_scores_gemma":[0.997717,0.000114626855,0.0005545885,0.000026061076,0.000017795106,0.000005602737,0.00006836228,0.000019912855,0.001476041],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.99981016,0.00002753873,0.000023327904,0.00003567275,0.0000727679,0.00003050906],"domain_scores_gemma":[0.9997398,0.00006944424,0.000075141346,0.000021370462,0.00001181466,0.0000824832],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009517692,0.0006090301,0.0002321428,0.0005669184,0.00034934,0.00024798786,0.00026773644,0.0008926428,0.0026905213],"category_scores_gemma":[0.0003465196,0.00027085724,0.00028647282,0.00025537112,0.00044849128,0.00020856368,0.00046520174,0.0005204969,0.0009438773],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009263117,0.00017094925,0.0125325015,0.00006186007,0.00008175558,0.14178012,0.00028288522,0.00041871885,0.8312395,0.0021161863,0.000414322,0.009974887],"study_design_scores_gemma":[0.00031409482,0.00084272295,0.21699162,0.000028780729,0.00026627944,0.44264224,0.00039736068,0.004313542,0.32362863,0.0015353896,0.008982823,0.000056511493],"about_ca_topic_score_codex":0.0004596414,"about_ca_topic_score_gemma":0.00072072505,"teacher_disagreement_score":0.0026905213,"about_ca_system_score_codex":0.00016509237,"about_ca_system_score_gemma":0.0001869939,"threshold_uncertainty_score":0.009000719},"labels":[],"label_agreement":null},{"id":"W2751988018","doi":"10.1083/jcb.201705085","title":"A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria","year":2017,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Howard Hughes Medical Institute; Canada Research Chairs; Canadian Institutes of Health Research; Sick Kids Foundation; European Molecular Biology Organization; Hospital for Sick Children; Weston Brain Institute","keywords":"Wallerian degeneration; Axotomy; Biology; Degeneration (medical); Neuroprotection; Mitochondrion; Axon; Neuroscience; Tropomyosin receptor kinase A; Neurodegeneration; Cell biology; Nerve growth factor; Central nervous system; Receptor; Pathology; Biochemistry; Medicine","score_opus":0.023719999934181328,"score_gpt":0.2935880305759772,"score_spread":0.2698680306417959,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2751988018","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9744665,0.013396742,0.0046536876,0.00026942955,0.00006940877,0.000114453505,0.00058637507,0.00021854888,0.0062248576],"genre_scores_gemma":[0.9812227,0.008517513,0.0053294976,0.00013228861,0.000022962107,0.000046547495,0.0007588923,0.000014222989,0.0039554285],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999566,0.0000035035732,0.0000038547064,0.00000995706,0.000010663211,0.000015486055],"domain_scores_gemma":[0.9999728,0.0000024632975,0.000006634255,0.0000032555586,0.0000049228074,0.000009917929],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008241767,0.0003585882,0.00028352553,0.00039984725,0.00017297368,0.00020942852,0.00024877457,0.00022947455,0.001128617],"category_scores_gemma":[0.00005446599,0.000098434204,0.00021794802,0.00018491058,0.00014225785,0.00019126163,0.00012749132,0.00053990533,0.00025874842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014082143,0.00007771123,0.00016763293,0.000089857436,0.0000131273955,0.00008920246,0.000012144192,0.000111409754,0.98643935,0.00018900305,0.000109251254,0.012560348],"study_design_scores_gemma":[0.00008273567,0.0014064829,0.002311936,0.000011392468,0.000037779504,0.00058004144,0.0000123507425,0.00025880316,0.9891887,0.00006282174,0.0060405745,0.0000064377145],"about_ca_topic_score_codex":0.00053087017,"about_ca_topic_score_gemma":0.002821903,"teacher_disagreement_score":0.001128617,"about_ca_system_score_codex":0.00027978173,"about_ca_system_score_gemma":0.00029948328,"threshold_uncertainty_score":0.0037755966},"labels":[],"label_agreement":null},{"id":"W2753735822","doi":"10.1158/1535-7163.mct-17-0397","title":"Death by HDAC Inhibition in Synovial Sarcoma Cells","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"","keywords":"Synovial sarcoma; Cancer research; Apoptosis; Sarcoma; Cancer; Histone deacetylase; Histone deacetylase inhibitor; Transcriptome; Biology; Cancer cell; Medicine; Histone; Pathology; Internal medicine; Gene expression; Biochemistry","score_opus":0.02300530319860789,"score_gpt":0.32064326584401637,"score_spread":0.2976379626454085,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2753735822","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9787199,0.006037771,0.0051137838,0.00022632291,0.00012288873,0.00010099629,0.0026082832,0.00022107994,0.006849044],"genre_scores_gemma":[0.9904965,0.0017563138,0.0018230974,0.00006706867,0.000012052499,0.00005874903,0.0018042949,0.000011795972,0.003970058],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998733,0.000012828557,0.0000140860275,0.000026659047,0.000045130048,0.000027978676],"domain_scores_gemma":[0.99996555,0.0000050389394,0.000007660806,0.000006552091,0.000006930056,0.000008366724],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010845514,0.0002478165,0.00029776958,0.00020922214,0.00017282895,0.00024179489,0.00012039083,0.00013714825,0.0021077644],"category_scores_gemma":[0.00006764196,0.000076441196,0.00029362467,0.00023280708,0.00014530383,0.0001068631,0.00013442246,0.00045730767,0.0007116768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023615906,0.000053329593,0.00042979018,0.00007714107,0.000011534235,0.00008099811,0.000025552874,0.00011610855,0.993802,0.00017261758,0.00028323472,0.004711646],"study_design_scores_gemma":[0.000049719394,0.00049749867,0.0051358435,0.000008233747,0.000021274831,0.00034560336,0.000058534228,0.0011041281,0.98720455,0.000098953446,0.0054713194,0.0000042932406],"about_ca_topic_score_codex":0.0012414651,"about_ca_topic_score_gemma":0.0016312165,"teacher_disagreement_score":0.0021077644,"about_ca_system_score_codex":0.00030502363,"about_ca_system_score_gemma":0.00025958804,"threshold_uncertainty_score":0.00705117},"labels":[],"label_agreement":null},{"id":"W2759811398","doi":"","title":"Effects of Histone Deacetylase Inhibitors on the Maintenance of Midbrain Neurons and Glia","year":2012,"lang":"en","type":"dissertation","venue":"Library and Archives Canada (Government of Canada)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Histone deacetylase; HDAC10; Midbrain; HDAC11; Neuroscience; HDAC1; Histone deacetylase 2; Histone deacetylase 5; Histone; Cell biology; Chemistry; Biology; Central nervous system; Biochemistry","score_opus":0.0022727474370506603,"score_gpt":0.17988467627751964,"score_spread":0.17761192884046897,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2759811398","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97530854,0.018177554,0.0014157176,0.00043336043,0.00033637503,0.000093490315,0.0005608593,0.00011393346,0.003560297],"genre_scores_gemma":[0.9691135,0.02053693,0.0030040676,0.00025612777,0.00009780751,0.00011021739,0.0008655808,0.000035914625,0.0059797433],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998878,0.000014311635,0.000013060527,0.00002524204,0.000026566899,0.000032909084],"domain_scores_gemma":[0.9999149,0.00001866184,0.000022258235,0.000008209789,0.000014448201,0.000021506723],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016992763,0.0003187055,0.0003478974,0.00020089476,0.00015006431,0.00029465946,0.0003466969,0.00021011978,0.0014220239],"category_scores_gemma":[0.00010702392,0.00014046216,0.0003662509,0.00013651076,0.00012824655,0.00015317355,0.00013469666,0.0007852771,0.00034388845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010247458,0.00029599675,0.00029731228,0.0002590633,0.00005550365,0.000079477264,0.000043986212,0.00022212729,0.981697,0.00013960004,0.0004242332,0.0154610155],"study_design_scores_gemma":[0.00011356834,0.0036560192,0.00417897,0.000026155913,0.000079893645,0.000110799025,0.00006377281,0.0005186117,0.98652214,0.00005286094,0.004669722,0.000007443658],"about_ca_topic_score_codex":0.0007110989,"about_ca_topic_score_gemma":0.0026175093,"teacher_disagreement_score":0.0014220239,"about_ca_system_score_codex":0.00018088643,"about_ca_system_score_gemma":0.0002940432,"threshold_uncertainty_score":0.0047571063},"labels":[],"label_agreement":null},{"id":"W2763250708","doi":"10.1021/acs.jmedchem.7b00933","title":"Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Structural Genomics Consortium; Diamond Light Source; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Wellcome Trust","keywords":"Chemistry; HDAC6; Ubiquitin; Zinc finger; Small molecule; Histone deacetylase; RING finger domain; Ligand (biochemistry); Computational biology; Acetylation; Binding site; Binding domain; Histone; Biophysics; Cell biology; Biochemistry; Receptor; DNA; Biology; Transcription factor","score_opus":0.02192232480933046,"score_gpt":0.317672498640149,"score_spread":0.29575017383081853,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2763250708","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97196364,0.008882746,0.012297273,0.0004426915,0.00011824423,0.000312447,0.00058639736,0.00020729346,0.0051891347],"genre_scores_gemma":[0.98413694,0.0035672742,0.0065304674,0.00011778349,0.000024438647,0.000105874264,0.00063411705,0.000012670167,0.004870481],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998926,0.000018768922,0.000006464277,0.000013309146,0.000034168803,0.00003464101],"domain_scores_gemma":[0.9999428,0.00001562481,0.000014201894,0.000005104429,0.000005198799,0.000017008306],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022365956,0.00041029998,0.00041704593,0.00016376299,0.00014408899,0.00028764718,0.00040609683,0.0002630416,0.0017897221],"category_scores_gemma":[0.00011253804,0.00015214746,0.00023897034,0.00015331616,0.0002467706,0.00016338742,0.0001819154,0.0007836057,0.00045024688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003300692,0.00024443917,0.00031316644,0.00008888148,0.000031586816,0.00010279791,0.000019074185,0.0008732191,0.98659,0.0009901901,0.00031910927,0.010097511],"study_design_scores_gemma":[0.0002743668,0.001626862,0.0012612841,0.000007656391,0.00003925457,0.00021811496,0.0000151556205,0.0021642882,0.98722523,0.0001387243,0.0070175626,0.000011506149],"about_ca_topic_score_codex":0.00044951699,"about_ca_topic_score_gemma":0.0019123434,"teacher_disagreement_score":0.0017897221,"about_ca_system_score_codex":0.0003967907,"about_ca_system_score_gemma":0.00029082914,"threshold_uncertainty_score":0.005987227},"labels":[],"label_agreement":null},{"id":"W2763301729","doi":"10.1101/203372","title":"Methods for addressing the protein-protein interaction between histone deacetylase 6 and ubiquitin","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Fondation Pierre Mercier; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"HDAC6; Aggresome; Histone deacetylase; Chemistry; Ubiquitin; Acetylation; Cell biology; HDAC10; Small molecule; Biochemistry; Histone; Biology","score_opus":0.05786674604631126,"score_gpt":0.3734218626709627,"score_spread":0.31555511662465147,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2763301729","genre_codex":"methods","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":"methods","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.19702762,0.013039273,0.7751415,0.0008056226,0.0006613296,0.0012521606,0.0019142285,0.0014280103,0.008730321],"genre_scores_gemma":[0.29769665,0.009328412,0.6597469,0.00047490984,0.00012465252,0.0031265086,0.0037031493,0.0004685223,0.025330199],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99882,0.00027688086,0.00010561367,0.0002810593,0.0004281733,0.00008825732],"domain_scores_gemma":[0.9992305,0.00034273317,0.00013307446,0.00013641197,0.00010244669,0.000054894994],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001505836,0.0013512882,0.0006287489,0.0011451751,0.0005225507,0.00063883147,0.00094028015,0.0008130733,0.0032704822],"category_scores_gemma":[0.00096618105,0.00072449946,0.0008122517,0.00058161997,0.00047313105,0.00057366805,0.0007389312,0.0016021606,0.0022107814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007887306,0.0000691104,0.00015446101,0.0002662245,0.000025233854,0.000050331997,0.000025705867,0.0001456052,0.9914709,0.0006976576,0.00024733317,0.0067687044],"study_design_scores_gemma":[0.000025131536,0.00012258961,0.00046186717,0.000015506024,0.000026533158,0.00013776535,0.0000107097585,0.0013375273,0.98745257,0.0002673916,0.010130174,0.000012447647],"about_ca_topic_score_codex":0.00039730154,"about_ca_topic_score_gemma":0.00076191407,"teacher_disagreement_score":0.0032704822,"about_ca_system_score_codex":0.0006110796,"about_ca_system_score_gemma":0.00041070307,"threshold_uncertainty_score":0.01094085},"labels":[],"label_agreement":null},{"id":"W2767773409","doi":"10.1038/s41467-017-01657-3","title":"Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ontario Ministry of Research, Innovation and Science; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Genome Canada; Ontario Genomics; Pfizer","keywords":"Chemical biology; Computational biology; Chemistry; Epigenetics; Histone acetyltransferase; Biochemistry; Bioassay; Histone; Biology; Genetics; Gene","score_opus":0.023616858815945385,"score_gpt":0.34734123109490833,"score_spread":0.32372437227896295,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2767773409","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87121993,0.028567893,0.065430425,0.0010083375,0.0005277831,0.0011382023,0.0044549378,0.0019322764,0.02572018],"genre_scores_gemma":[0.9482984,0.011003317,0.024322812,0.0009719764,0.00014491462,0.000729137,0.0056832,0.0003526367,0.00849359],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9953885,0.0014058272,0.0005052076,0.0006511151,0.0017683721,0.00028082952],"domain_scores_gemma":[0.9974485,0.0011266008,0.00036443482,0.00039527987,0.0005727697,0.00009239469],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0022935006,0.0011845536,0.0009422662,0.0007886314,0.00048303686,0.0007630828,0.00065596885,0.0006434893,0.0034621104],"category_scores_gemma":[0.003307964,0.00038962075,0.0005922345,0.00083517266,0.000528723,0.00041069544,0.0006962645,0.0010714297,0.0012942534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021402819,0.00018272996,0.002113656,0.0004151954,0.00008595532,0.00013733655,0.00011277729,0.00047643806,0.9794423,0.0002908147,0.00083752675,0.015691254],"study_design_scores_gemma":[0.000012713299,0.0007418541,0.0020654416,0.0000274413,0.00008511144,0.0003232699,0.000030229881,0.0007190327,0.99007565,0.000071679075,0.0058329646,0.000014584017],"about_ca_topic_score_codex":0.00072119985,"about_ca_topic_score_gemma":0.0015172239,"teacher_disagreement_score":0.0034621104,"about_ca_system_score_codex":0.00057106226,"about_ca_system_score_gemma":0.00050098536,"threshold_uncertainty_score":0.012129307},"labels":[],"label_agreement":null},{"id":"W2767841440","doi":"10.1021/acs.jproteome.7b00270","title":"Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis","year":2017,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences Centre; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; University of Manitoba; Spinal Cord Injury Canada","keywords":"Experimental autoimmune encephalomyelitis; Citrullination; Myelin basic protein; Acetylation; Lysine; Multiple sclerosis; Myelin oligodendrocyte glycoprotein; Arginine; Encephalomyelitis; Myelin; Chemistry; Immunology; Citrulline; Biochemistry; Medicine; Biology; Neuroscience; Central nervous system; Amino acid","score_opus":0.071306543506195,"score_gpt":0.3343446416447336,"score_spread":0.2630380981385386,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2767841440","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9940434,0.0022352156,0.0018417173,0.000102412945,0.000035905272,0.000029223562,0.00064987555,0.000096231095,0.0009659622],"genre_scores_gemma":[0.9910734,0.0017893409,0.002844812,0.00010948284,0.000020970687,0.000082451246,0.0011439043,0.00003126507,0.002904431],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977785,0.000022825057,0.00002029119,0.000051324845,0.00006630182,0.00006146694],"domain_scores_gemma":[0.99973077,0.000014163908,0.00010727221,0.000013755115,0.000028623863,0.00010538756],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015297532,0.000598211,0.00044348746,0.0007295492,0.00022810334,0.0002756531,0.00017359164,0.00039339685,0.0012167738],"category_scores_gemma":[0.00010981488,0.00020100838,0.00032209055,0.00040708698,0.00029388568,0.00024396261,0.00020480351,0.0009886364,0.00032245956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026107393,0.000043334087,0.0005754765,0.000029112392,0.000010378542,0.00003672893,0.0000113691,0.000010391942,0.99844944,0.000009761795,0.000018732935,0.0005441713],"study_design_scores_gemma":[0.000027378792,0.0012555857,0.059098523,0.000011947663,0.000057518733,0.00052276574,0.000052848143,0.00033409146,0.9375625,0.0000640909,0.0010028463,0.000009815636],"about_ca_topic_score_codex":0.0006104358,"about_ca_topic_score_gemma":0.0012655449,"teacher_disagreement_score":0.0012167738,"about_ca_system_score_codex":0.00028501017,"about_ca_system_score_gemma":0.00016957139,"threshold_uncertainty_score":0.0040705204},"labels":[],"label_agreement":null},{"id":"W2769007711","doi":"10.1038/leu.2017.299","title":"HDAC6 regulates microRNA-27b that suppresses proliferation, promotes apoptosis and target MET in diffuse large B-cell lymphoma","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Shanghai Hospital Development Center; Science and Technology Commission of Shanghai Municipality; University of British Columbia; University of Texas MD Anderson Cancer Center; National Natural Science Foundation of China; Cancer Prevention and Research Institute of Texas","keywords":"Cancer research; Diffuse large B-cell lymphoma; microRNA; Gene knockdown; Cell growth; Protein kinase B; Biology; HDAC6; PI3K/AKT/mTOR pathway; Lymphoma; Histone deacetylase; In vivo; Apoptosis; Signal transduction; Cell biology; Histone; Immunology; Gene","score_opus":0.010720303980935958,"score_gpt":0.2567826952914495,"score_spread":0.24606239131051352,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2769007711","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9817348,0.0062488844,0.0035167313,0.0007074127,0.00026945552,0.000029571398,0.00097109453,0.00041015376,0.0061118854],"genre_scores_gemma":[0.99331856,0.0010823342,0.0009840635,0.00018407016,0.00003035109,0.00002150358,0.00061006634,0.00007547937,0.0036936484],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99974936,0.000041429736,0.000017455142,0.000045497414,0.00007752971,0.000068725385],"domain_scores_gemma":[0.99987686,0.000008525797,0.000040678144,0.000010434137,0.0000146085895,0.000048823407],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025090363,0.00041493628,0.00030892243,0.00038298336,0.0002575839,0.00049604254,0.00036481692,0.00023714911,0.0025741248],"category_scores_gemma":[0.00018220497,0.00032502436,0.00035744536,0.00019545616,0.00038401302,0.00018502364,0.00027988123,0.0007444304,0.0010704038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009003129,0.000057506608,0.0016590721,0.000063064515,0.000032280317,0.00015829431,0.000017583308,0.00015775478,0.9918719,0.00043050235,0.0007636388,0.0038881355],"study_design_scores_gemma":[0.00034258552,0.0005714763,0.043382227,0.000014816379,0.00013852377,0.0013441738,0.00016815671,0.0034626487,0.93485916,0.00046745533,0.015230976,0.00001779745],"about_ca_topic_score_codex":0.0006619037,"about_ca_topic_score_gemma":0.001692973,"teacher_disagreement_score":0.0025741248,"about_ca_system_score_codex":0.0006080988,"about_ca_system_score_gemma":0.00027092616,"threshold_uncertainty_score":0.008611262},"labels":[],"label_agreement":null},{"id":"W2772410725","doi":"10.1161/strokeaha.117.016674","title":"Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack","year":2017,"lang":"en","type":"article","venue":"Stroke","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Blood Services","funders":"National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust","keywords":"Medicine; Stroke (engine); Hazard ratio; Proportional hazards model; Confidence interval; Internal medicine; Histone deacetylase inhibitor; Cardiology; Histone deacetylase; Histone","score_opus":0.01656436673188191,"score_gpt":0.29268156135786827,"score_spread":0.2761171946259864,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2772410725","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9944706,0.0043778676,0.000111239955,0.00018172235,0.00002970026,0.0000074773866,0.0002604942,0.000016449381,0.00054432364],"genre_scores_gemma":[0.9983156,0.0010188567,0.00007009291,0.00004807694,0.000035362293,0.0000034374984,0.0002626814,0.0000032164269,0.00024272868],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99953055,0.00017110984,0.00007276795,0.000092171715,0.000095202195,0.00003815054],"domain_scores_gemma":[0.9972722,0.0005806984,0.0016026641,0.0001514818,0.0000908801,0.00030207078],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005652194,0.00030809065,0.0005428766,0.0004521779,0.00020823997,0.00046914755,0.00027976918,0.00042986544,0.0020366353],"category_scores_gemma":[0.0030497015,0.00027686445,0.0006538065,0.00066479156,0.0003843058,0.00019293629,0.00026605342,0.00041737486,0.0002403324],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0063323965,0.00012700388,0.981529,0.00014494425,0.0012042964,0.00022633313,0.000051875377,0.000106768224,0.0011428933,0.000035620764,0.00025341896,0.008845415],"study_design_scores_gemma":[0.00012634705,0.00048188597,0.99810934,0.0000151567365,0.00026143488,0.00041386063,0.000015409492,0.00015449201,0.00014191444,0.000052151918,0.00022407481,0.0000038185717],"about_ca_topic_score_codex":0.0023459196,"about_ca_topic_score_gemma":0.003128854,"teacher_disagreement_score":0.0023459196,"about_ca_system_score_codex":0.00024661957,"about_ca_system_score_gemma":0.00023544092,"threshold_uncertainty_score":0.006813228},"labels":[],"label_agreement":null},{"id":"W2773849850","doi":"10.1007/s00280-017-3494-3","title":"Phase I/II study of mocetinostat in combination with gemcitabine for patients with advanced pancreatic cancer and other advanced solid tumors","year":2017,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"Mirati Therapeutics","keywords":"Gemcitabine; Medicine; Pancreatic cancer; Internal medicine; Adverse effect; Cancer; Clinical endpoint; Phases of clinical research; Gastroenterology; Maximum tolerated dose; Oncology; Clinical trial","score_opus":0.012006969423434283,"score_gpt":0.36023163951508524,"score_spread":0.348224670091651,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2773849850","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9883158,0.00291143,0.0007253474,0.0009485274,0.0002827315,0.0028933391,0.001483477,0.00013475298,0.002304581],"genre_scores_gemma":[0.9832131,0.0039685974,0.0021216308,0.0010232287,0.0002241737,0.0028392002,0.0028266145,0.000074631454,0.0037086788],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99962175,0.00014739379,0.000017744842,0.00008101376,0.00002211958,0.000109858585],"domain_scores_gemma":[0.99947435,0.000059869504,0.000068505484,0.000048970847,0.000024232668,0.0003241145],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010484798,0.0017430659,0.0034092388,0.0007664874,0.00061001733,0.0014915208,0.001101269,0.001318032,0.0044985334],"category_scores_gemma":[0.00067239546,0.0009913131,0.0019533508,0.000827643,0.0013099381,0.0013030749,0.0004987695,0.0046899975,0.000977553],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.78746086,0.081804566,0.0052086855,0.0008942731,0.002134035,0.00025063808,0.00032128594,0.0043467516,0.03173314,0.00052515685,0.0049152696,0.080405354],"study_design_scores_gemma":[0.6567361,0.32822382,0.0062986133,0.000041790245,0.0007042372,0.00016900759,0.00009286119,0.0011240084,0.0029253892,0.00023218873,0.0034176812,0.000034373425],"about_ca_topic_score_codex":0.0021246893,"about_ca_topic_score_gemma":0.00634482,"teacher_disagreement_score":0.0044985334,"about_ca_system_score_codex":0.0013059165,"about_ca_system_score_gemma":0.0023735836,"threshold_uncertainty_score":0.0150491},"labels":[],"label_agreement":null},{"id":"W2783301628","doi":"10.1074/jbc.ra117.000529","title":"Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; McGill University; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Science Foundation; National Institutes of Health; National Cancer Institute; Wellcome Trust; U.S. Department of Defense","keywords":"Acetyltransferase; Histone acetyltransferase; Chemistry; Acetylation; Biology; Internal medicine; Endocrinology; Biochemistry; Medicine; Gene","score_opus":0.029498949203580312,"score_gpt":0.29067835878242876,"score_spread":0.26117940957884844,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2783301628","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98725224,0.0013581216,0.009109737,0.00020411497,0.000023523497,0.000010555019,0.0006703084,0.00011746694,0.0012539962],"genre_scores_gemma":[0.9844372,0.0011111654,0.009295652,0.00009291903,0.000011296549,0.000010443417,0.0012310775,0.00003789845,0.0037723044],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993455,0.000005227039,0.000003999752,0.000016401298,0.000023576866,0.000016194224],"domain_scores_gemma":[0.9999356,0.000008454381,0.000020966143,0.0000073395095,0.000009615794,0.000017907007],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008829821,0.00018061741,0.00009778876,0.00017875197,0.00011407614,0.00021691291,0.00016892393,0.00021456406,0.0010670867],"category_scores_gemma":[0.00008771679,0.000101421974,0.00026066342,0.00013028228,0.00010742227,0.00017564674,0.00019819461,0.0004576637,0.00035154985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000026118978,0.0000043136506,0.0006258905,0.000018465398,0.0000050292497,0.000034497083,0.000005428341,0.000028512432,0.9975916,0.00007710119,0.000034217068,0.0015488175],"study_design_scores_gemma":[0.0000032618266,0.00005889051,0.011148046,0.000002017476,0.000008349973,0.00035796294,0.000015677506,0.00096471165,0.9844499,0.000063769774,0.0029232975,0.00000410302],"about_ca_topic_score_codex":0.00121526,"about_ca_topic_score_gemma":0.001260344,"teacher_disagreement_score":0.00121526,"about_ca_system_score_codex":0.00021095024,"about_ca_system_score_gemma":0.00013923839,"threshold_uncertainty_score":0.0035697222},"labels":[],"label_agreement":null},{"id":"W2783484894","doi":"10.1016/j.ejmech.2018.01.021","title":"Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Celgene","keywords":"Chemistry; Histone deacetylase; Tubulin; Carboxamide; Stereochemistry; Cytotoxicity; Docking (animal); Triazole; Histone; Microtubule; Biochemistry; In vitro; DNA; Cell biology; Biology","score_opus":0.034817907610423214,"score_gpt":0.3329971388446725,"score_spread":0.29817923123424933,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2783484894","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94741106,0.028487347,0.014291419,0.0003365101,0.00015494322,0.0004249596,0.0005257441,0.00034964024,0.008018247],"genre_scores_gemma":[0.9783483,0.012618955,0.004624522,0.00008243374,0.000030478563,0.00006989898,0.00041233678,0.000020092317,0.0037929812],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999026,0.000021480815,0.0000064953015,0.000013241192,0.00002326283,0.000032986427],"domain_scores_gemma":[0.9999373,0.000008168478,0.000016250615,0.0000064488145,0.000012201585,0.000019683619],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028235826,0.00032400127,0.00037396172,0.00021214371,0.00012585573,0.00020355172,0.0004282078,0.00025996874,0.0010114893],"category_scores_gemma":[0.00018520225,0.00014125663,0.00024093925,0.00025208984,0.00020499947,0.00017172098,0.00014362465,0.0004197371,0.00030119182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00076102116,0.00033839248,0.00047100295,0.00034502454,0.00004111337,0.0004253163,0.0001787434,0.0024874425,0.95414054,0.0018550488,0.00071309356,0.038243238],"study_design_scores_gemma":[0.0008048689,0.009125606,0.0045219315,0.00004368255,0.00014765332,0.0011502285,0.00008727229,0.0038503422,0.9537218,0.00023989231,0.026255446,0.000051274652],"about_ca_topic_score_codex":0.0016068103,"about_ca_topic_score_gemma":0.0042986306,"teacher_disagreement_score":0.0016068103,"about_ca_system_score_codex":0.00039358926,"about_ca_system_score_gemma":0.00036073412,"threshold_uncertainty_score":0.0033837557},"labels":[],"label_agreement":null},{"id":"W2789912283","doi":"10.1016/j.ebiom.2018.01.014","title":"Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway","year":2018,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; National Institutes of Health; Weill Cornell Medical College; Helmholtz Association; Irma T. Hirschl Trust; Doris Duke Charitable Foundation","keywords":"Reprogramming; Histone deacetylase inhibitor; Metabolomics; Lysine; Biology; Choline; Cancer research; Histone deacetylase; Computational biology; Cell biology; Chemistry; Cell; Biochemistry; Bioinformatics; Histone; Amino acid; Gene","score_opus":0.010546996803399506,"score_gpt":0.2718097716362717,"score_spread":0.2612627748328722,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2789912283","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9855914,0.0037904875,0.005232337,0.00019442332,0.000022132268,0.000037851085,0.003808647,0.0001111219,0.0012117396],"genre_scores_gemma":[0.98828065,0.0022354627,0.0041651037,0.0002133603,0.000010068046,0.00004807582,0.0032765702,0.000030259565,0.0017404822],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992716,0.000012150427,0.000003744132,0.000022535818,0.000018254465,0.000016227714],"domain_scores_gemma":[0.9999639,0.0000047461226,0.000009461287,0.0000032886596,0.000010480453,0.000008151303],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008710646,0.00022904766,0.0002527401,0.00039962068,0.0001232235,0.00030163006,0.00009296943,0.00018573951,0.0007942031],"category_scores_gemma":[0.00010377967,0.00008386151,0.00020147426,0.00043504292,0.00008107248,0.00013849686,0.00017757877,0.00025134394,0.00018213462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038527223,0.000018284083,0.0027746628,0.00003126963,0.00002773653,0.000039531413,0.00001591281,0.000086114786,0.99231976,0.000033585988,0.00006704867,0.0042008804],"study_design_scores_gemma":[0.00003721627,0.0006336971,0.16627881,0.000016933069,0.00018204644,0.00053104595,0.00019445259,0.0031378854,0.82272375,0.00033113558,0.005905005,0.00002814482],"about_ca_topic_score_codex":0.0010036061,"about_ca_topic_score_gemma":0.0016036883,"teacher_disagreement_score":0.0010036061,"about_ca_system_score_codex":0.00018589119,"about_ca_system_score_gemma":0.00017101182,"threshold_uncertainty_score":0.002656877},"labels":[],"label_agreement":null},{"id":"W2790539376","doi":"10.3389/fphar.2018.00034","title":"HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University; St. Michael's Hospital","funders":"Banting and Best Diabetes Centre, University of Toronto; Novo Nordisk; Kidney Foundation of Canada; Canadian Society of Nephrology; Heart and Stroke Foundation of Canada","keywords":"Transcription factor; HDAC6; Cell biology; Chemistry; Cancer research; Pharmacology; Medicine; Biology; Biochemistry; DNA; Gene","score_opus":0.012450791485388099,"score_gpt":0.30281913464078947,"score_spread":0.2903683431554014,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2790539376","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9826872,0.009315702,0.002958887,0.0005139262,0.00033060057,0.000039389528,0.0008335726,0.00033597366,0.002984798],"genre_scores_gemma":[0.9918269,0.0027883612,0.0010257636,0.0001367934,0.00006332103,0.000038346563,0.00078170275,0.000046003504,0.0032927664],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982977,0.00002109615,0.000022487875,0.0000330458,0.000040748484,0.00005277517],"domain_scores_gemma":[0.999851,0.000010804301,0.000035296845,0.000019171428,0.000021361917,0.00006234326],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026256882,0.00044043871,0.00072558975,0.00034629324,0.00018973822,0.00029924093,0.00027989698,0.00030206607,0.003572372],"category_scores_gemma":[0.00018918543,0.00017510043,0.00057850016,0.00020182303,0.00028022326,0.0002618166,0.00021537491,0.00072531257,0.00055120233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0025853936,0.00021479205,0.00076085824,0.00014697191,0.000045728942,0.00009004945,0.00001830148,0.00006461625,0.9906538,0.00014672373,0.00023451017,0.0050382307],"study_design_scores_gemma":[0.00038534644,0.0028244972,0.031737246,0.000024259833,0.00011744671,0.0004835817,0.00006976947,0.0009474424,0.9572094,0.00021919556,0.0059676627,0.00001426007],"about_ca_topic_score_codex":0.0006602093,"about_ca_topic_score_gemma":0.0010855156,"teacher_disagreement_score":0.003572372,"about_ca_system_score_codex":0.00025204514,"about_ca_system_score_gemma":0.00022773238,"threshold_uncertainty_score":0.011950791},"labels":[],"label_agreement":null},{"id":"W2790915935","doi":"10.1093/jcag/gwy008.268","title":"A267 EPIGENETIC ERASERS HDAC1 AND HDAC2 DRIVE INTESTINAL EPITHELIAL CELL BEHAVIOR","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"HDAC1; Histone deacetylase 2; Biology; Cell biology; Molecular biology; Chemistry; Biochemistry; Histone; Histone deacetylase; Gene","score_opus":0.005580200172110166,"score_gpt":0.2321640901951735,"score_spread":0.22658389002306334,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2790915935","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9832803,0.0013921413,0.005960856,0.0002434614,0.00012002514,0.0000462709,0.0019188663,0.00042698873,0.0066111647],"genre_scores_gemma":[0.9801398,0.000979063,0.0030028804,0.00018003129,0.0000322111,0.000079261634,0.0018112666,0.00022667568,0.013548739],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99961555,0.000037137685,0.00002497354,0.000083693136,0.00011889057,0.00011966488],"domain_scores_gemma":[0.99984026,0.000014042027,0.000037744994,0.000022125703,0.00001586547,0.00006993361],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022090734,0.0003952045,0.00035099746,0.0003895959,0.00024959136,0.00043661773,0.00030079382,0.00038190943,0.0039629233],"category_scores_gemma":[0.0001094899,0.00026430664,0.0005813709,0.000260826,0.00034282202,0.00017053861,0.0003637546,0.001013388,0.001588408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013792895,0.000046848636,0.00025919778,0.00002884739,0.000005447849,0.000048469818,0.000018094946,0.00005030287,0.99792624,0.00016727408,0.00013692882,0.001174394],"study_design_scores_gemma":[0.000048231283,0.00045518088,0.009686168,0.000014738553,0.00003580104,0.00027690045,0.00011744465,0.0017140595,0.9787411,0.0001380554,0.00876063,0.000011665672],"about_ca_topic_score_codex":0.00069867563,"about_ca_topic_score_gemma":0.0013412047,"teacher_disagreement_score":0.0039629233,"about_ca_system_score_codex":0.00029602286,"about_ca_system_score_gemma":0.00028376645,"threshold_uncertainty_score":0.013257325},"labels":[],"label_agreement":null},{"id":"W2791913918","doi":"10.1155/2018/2379546","title":"Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity","year":2018,"lang":"en","type":"article","venue":"Stem Cells International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Novo Nordisk Fonden; King Saud University","keywords":"Mesenchymal stem cell; Cell biology; Romidepsin; Chemistry; Biology; Biochemistry; Gene; Histone","score_opus":0.01841066213868914,"score_gpt":0.2819884853044807,"score_spread":0.26357782316579154,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2791913918","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98500407,0.004910694,0.0035014513,0.00015851112,0.000043261727,0.000079802056,0.0007295038,0.00015303951,0.0054197283],"genre_scores_gemma":[0.98606795,0.00388693,0.0030170237,0.00008724237,0.000018317292,0.000056048622,0.0009766918,0.00001761678,0.0058721956],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993956,0.0000120587365,0.000006669864,0.000010245385,0.00002091953,0.000010620627],"domain_scores_gemma":[0.9999765,0.000004940217,0.0000062690974,0.0000030454871,0.0000036098515,0.0000056206336],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006156054,0.0002517118,0.00014407044,0.00016311687,0.00005641518,0.00011389668,0.00008460966,0.00009159211,0.0012235787],"category_scores_gemma":[0.000049710932,0.00007852096,0.00015418816,0.00010284054,0.000093458846,0.000050075818,0.00011715002,0.00024959876,0.0003832516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009359039,0.000031207906,0.000121862366,0.000040964987,0.000004537921,0.00004337341,0.000007072234,0.000038652383,0.9969024,0.00003098342,0.00005197349,0.0026333884],"study_design_scores_gemma":[0.000021251866,0.00028493127,0.003505097,0.0000044076587,0.000012202289,0.00016537125,0.000010301792,0.00027334783,0.99301106,0.0000160952,0.0026940487,0.0000017994225],"about_ca_topic_score_codex":0.0005505179,"about_ca_topic_score_gemma":0.0011909293,"teacher_disagreement_score":0.0012235787,"about_ca_system_score_codex":0.0001001673,"about_ca_system_score_gemma":0.00017842826,"threshold_uncertainty_score":0.00409323},"labels":[],"label_agreement":null},{"id":"W2794971102","doi":"10.1021/acs.jmedchem.8b00258","title":"Identification and Structure–Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Chemistry; Ubiquitin; Proteasome; Zinc finger; Binding domain; Ligand (biochemistry); Binding site; Biochemistry; Cell biology; Biophysics; Computational biology; Receptor; Biology","score_opus":0.012246674837135353,"score_gpt":0.29443520134821893,"score_spread":0.28218852651108356,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2794971102","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96562606,0.01689949,0.005928871,0.0002233683,0.00004006691,0.00022035623,0.002337127,0.00017640658,0.008548195],"genre_scores_gemma":[0.980472,0.007294414,0.0051995576,0.00010662844,0.000020670195,0.000054136675,0.00350495,0.000020374298,0.0033272312],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987423,0.000017985009,0.000009509048,0.000021094773,0.000045027857,0.000032074407],"domain_scores_gemma":[0.99991953,0.000013467599,0.000015516287,0.000007743312,0.000023248474,0.000020511134],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021827473,0.00044467745,0.00051203015,0.00048643758,0.00015966022,0.00037873592,0.00037419135,0.00023681085,0.0023981552],"category_scores_gemma":[0.00021363543,0.00016737338,0.00039463167,0.000460364,0.00011804813,0.0002563765,0.00019120274,0.00048146292,0.0006544112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001118109,0.0008128607,0.0027246515,0.00024775486,0.00011850158,0.00018544377,0.000031700103,0.005950275,0.9454613,0.0006639084,0.00080988003,0.04187577],"study_design_scores_gemma":[0.00024208569,0.004866164,0.008117525,0.000016587583,0.00019280112,0.00082330994,0.000030129386,0.007367543,0.96535313,0.00022075874,0.01273995,0.000029950794],"about_ca_topic_score_codex":0.00090423436,"about_ca_topic_score_gemma":0.0014559646,"teacher_disagreement_score":0.0023981552,"about_ca_system_score_codex":0.00044601678,"about_ca_system_score_gemma":0.00027052558,"threshold_uncertainty_score":0.008022666},"labels":[],"label_agreement":null},{"id":"W2808006832","doi":"10.1101/345637","title":"A synthetic non-histone substrate provides insight into substrate targeting by the Gcn5 HAT and sirtuin HDACs","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Histone; Sirtuin; Biology; Computational biology; Histone Acetyltransferases; Histone code; Enzyme; Proteome; Biochemistry; Cell biology; Genetics; Acetylation; Gene; Nucleosome","score_opus":0.009017757693327796,"score_gpt":0.24085425434268734,"score_spread":0.23183649664935954,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2808006832","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9629113,0.0023070427,0.028218552,0.00025349835,0.00010967966,0.00005336192,0.0010536461,0.00017534751,0.0049176067],"genre_scores_gemma":[0.9716125,0.0008198843,0.023993913,0.000089103465,0.000010266396,0.000016266828,0.0008198366,0.00006683152,0.002571437],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998715,0.00002459676,0.000014802521,0.000031443025,0.000040352897,0.000017271243],"domain_scores_gemma":[0.9998983,0.000020633315,0.000023471446,0.000021632191,0.000013978093,0.000021936252],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002350159,0.00029176896,0.0001681479,0.00013911232,0.0001284453,0.00035826772,0.0002754209,0.0002305487,0.0011136264],"category_scores_gemma":[0.00015066292,0.00016456444,0.00021945064,0.00013227436,0.00016179244,0.0001700437,0.00020921096,0.0004299423,0.00043352754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006681879,0.000012818713,0.0002202199,0.000023856599,0.000004170065,0.00004044656,0.000007621829,0.00022223598,0.9977939,0.0004277681,0.00003087509,0.0011492968],"study_design_scores_gemma":[0.0000057650063,0.000066808854,0.00045727182,0.0000024047526,0.0000059933664,0.000088540866,0.000010761733,0.0009956247,0.9953809,0.00008069568,0.002901293,0.000003839718],"about_ca_topic_score_codex":0.0006849706,"about_ca_topic_score_gemma":0.0012402672,"teacher_disagreement_score":0.0011136264,"about_ca_system_score_codex":0.00035934467,"about_ca_system_score_gemma":0.00019157483,"threshold_uncertainty_score":0.003725469},"labels":[],"label_agreement":null},{"id":"W2808245579","doi":"10.1155/2018/2682037","title":"Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats","year":2018,"lang":"en","type":"article","venue":"Neural Plasticity","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Ministry of Education, Science and Technology; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; National Research Foundation","keywords":"Haloperidol; Olanzapine; Epigenetics; Antipsychotic; Histone; Chromatin immunoprecipitation; Pharmacology; Typical antipsychotic; Atypical antipsychotic; Neurotrophic factors; Brain-derived neurotrophic factor; Endocrinology; Medicine; Internal medicine; Biology; Gene expression; Dopamine; Psychiatry; Schizophrenia (object-oriented programming); Receptor; Genetics; Gene; Promoter","score_opus":0.020216595660573416,"score_gpt":0.28561483955521527,"score_spread":0.26539824389464184,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2808245579","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99803835,0.000770794,0.00031616597,0.000059134054,0.000023373603,0.000007806913,0.00024812957,0.00002248542,0.00051390607],"genre_scores_gemma":[0.9951508,0.0016012695,0.00079630536,0.00006865736,0.000011330794,0.00003327423,0.00046416177,0.000011335928,0.0018627002],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999347,0.000005920154,0.0000066934977,0.00001437697,0.000016325272,0.000022071266],"domain_scores_gemma":[0.9999223,0.0000057941097,0.000031377975,0.000009105909,0.000010327049,0.00002108022],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006457373,0.00037049732,0.0002991782,0.00022254576,0.0001436678,0.00015308199,0.00011219044,0.00014830085,0.0010572034],"category_scores_gemma":[0.00007836724,0.00016634875,0.0002825419,0.00012677825,0.00023239526,0.00010943969,0.00016731546,0.00048580833,0.00015644396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008378393,0.00006574295,0.00064118946,0.00003973477,0.000022599592,0.00006328887,0.000040779516,0.000029178347,0.9960432,0.000026288462,0.00004235028,0.0021478857],"study_design_scores_gemma":[0.00015279381,0.00345797,0.080445975,0.000026706444,0.00015211556,0.00031153532,0.000308029,0.0007155475,0.9123389,0.0001481492,0.0019177903,0.000024349678],"about_ca_topic_score_codex":0.0024517355,"about_ca_topic_score_gemma":0.008314474,"teacher_disagreement_score":0.0024517355,"about_ca_system_score_codex":0.00025628484,"about_ca_system_score_gemma":0.000272076,"threshold_uncertainty_score":0.004874885},"labels":[],"label_agreement":null},{"id":"W2809182872","doi":"10.1016/j.tranon.2018.06.001","title":"Activating Transcription Factor 3 as a Novel Regulator of Chemotherapy Response in Breast Cancer","year":2018,"lang":"en","type":"article","venue":"Translational Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Doxorubicin; Cytotoxicity; Activating transcription factor; Cancer research; Pharmacology; Downregulation and upregulation; Medicine; Transcription factor; Biology; Chemotherapy; In vitro; Internal medicine","score_opus":0.023523112027186963,"score_gpt":0.3541700893702453,"score_spread":0.3306469773430583,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2809182872","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97511715,0.013556732,0.0028537726,0.0005350739,0.00013286287,0.00008100109,0.0025090517,0.00019443498,0.005019872],"genre_scores_gemma":[0.9919733,0.0031465204,0.0012680554,0.00019486157,0.000028787264,0.000032042193,0.0016427082,0.000010572894,0.0017031517],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990654,0.000011200284,0.0000068772215,0.0000181641,0.000036005797,0.000021194752],"domain_scores_gemma":[0.9999368,0.000009423921,0.000026714391,0.0000034542172,0.000012393975,0.0000112062635],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012856796,0.00023278869,0.00022831526,0.00027766803,0.00015774506,0.00027788017,0.00012414317,0.00024932617,0.0014790074],"category_scores_gemma":[0.00012431873,0.00008222463,0.00025640827,0.00039151835,0.00011086123,0.00013072528,0.00010893617,0.0003788596,0.0002810902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005394753,0.00008009922,0.006629319,0.00017701404,0.000028204133,0.000316397,0.000044740624,0.0002863598,0.97951686,0.00024776184,0.0006262889,0.011507429],"study_design_scores_gemma":[0.00008343945,0.00077698467,0.18754852,0.00006177538,0.00018195866,0.002619519,0.00023988877,0.004389725,0.7756503,0.0005990497,0.0278128,0.000036016016],"about_ca_topic_score_codex":0.00057031406,"about_ca_topic_score_gemma":0.0009829033,"teacher_disagreement_score":0.0014790074,"about_ca_system_score_codex":0.00045452296,"about_ca_system_score_gemma":0.00022377346,"threshold_uncertainty_score":0.004947722},"labels":[],"label_agreement":null},{"id":"W2827741449","doi":"10.1016/j.stem.2018.05.026","title":"Mitochondrial Shapeshifting Impacts AML Stemness and Differentiation","year":2018,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; FIS1; Stem cell; Cell biology; Myeloid leukemia; Mitochondrial fission; Function (biology); Cellular differentiation; Mitochondrion; Myeloid cells; Myeloid; Cancer research; mitochondrial fusion; Genetics; Mitochondrial DNA; Gene","score_opus":0.011283146067835481,"score_gpt":0.23598027184667864,"score_spread":0.22469712577884315,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2827741449","genre_codex":"commentary","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.03680123,0.01069734,0.0025866253,0.8694323,0.044695564,0.00007550221,0.0006067615,0.0005300162,0.03457468],"genre_scores_gemma":[0.53739405,0.014810037,0.0038508286,0.2952341,0.04953108,0.00025214508,0.0005906637,0.00019484319,0.09814224],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996824,0.000055904347,0.000029102428,0.000049487295,0.00011847995,0.00006463809],"domain_scores_gemma":[0.9994073,0.00031898843,0.000051198094,0.00005498965,0.00007021963,0.00009735225],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004665293,0.00034980607,0.00039066307,0.00020091161,0.00080444454,0.0009786475,0.00034639722,0.0049976823,0.008451407],"category_scores_gemma":[0.0026808404,0.00014929987,0.00030473297,0.00015880149,0.00094273634,0.000605303,0.00044870083,0.005096512,0.0024134447],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0025720645,0.0002986538,0.0031493916,0.00022860266,0.00005995653,0.016754432,0.00019459217,0.0007424597,0.05145086,0.037006192,0.74965054,0.1378923],"study_design_scores_gemma":[0.0006800199,0.00053516205,0.0023939896,0.00007529458,0.000058660447,0.0091762915,0.00023746812,0.001636841,0.048448537,0.031417623,0.90529543,0.000044764958],"about_ca_topic_score_codex":0.0005153914,"about_ca_topic_score_gemma":0.0008530461,"teacher_disagreement_score":0.008451407,"about_ca_system_score_codex":0.0010645133,"about_ca_system_score_gemma":0.0004753615,"threshold_uncertainty_score":0.028272748},"labels":[],"label_agreement":null},{"id":"W2837590854","doi":"10.3389/fphar.2018.00737","title":"Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University; St. Michael's Hospital; McMaster University; University of Toronto; York University","funders":"Heart and Stroke Foundation of Canada","keywords":"Valproic Acid; Cancer research; Mesenchymal stem cell; Phenotype; Angiogenesis; Histone deacetylase inhibitor; Epithelial–mesenchymal transition; Fibrosis; Histone deacetylase; Nitric oxide; Endothelium; Anticonvulsant; Pharmacology; Chemistry; Cell biology; Medicine; Transition (genetics); Biology; Histone; Pathology; Gene; Epilepsy; Neuroscience; Internal medicine; Biochemistry","score_opus":0.010254774168956782,"score_gpt":0.2945955330954647,"score_spread":0.28434075892650795,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2837590854","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9878796,0.0068101496,0.0018093601,0.00016182927,0.000099384204,0.000037640344,0.00074383215,0.00010015566,0.0023580012],"genre_scores_gemma":[0.9937303,0.0028514594,0.001082391,0.000113835486,0.000016815542,0.000027317026,0.00059122336,0.000012296343,0.0015743583],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999075,0.00001852368,0.000011112804,0.000021010386,0.000022531613,0.000019301593],"domain_scores_gemma":[0.9999609,0.0000065815066,0.000012904842,0.0000043603195,0.000005225562,0.000010073207],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000074799354,0.00018544277,0.00018495643,0.00016292877,0.00008809232,0.00019878166,0.000077882396,0.00012162143,0.0007502596],"category_scores_gemma":[0.0000830988,0.00007828799,0.00019005472,0.000113462214,0.000115511415,0.00008998301,0.00011176834,0.0004238791,0.00014119213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004154018,0.000050980518,0.00030614808,0.000086112406,0.0000124879525,0.00006917901,0.000013346861,0.000054682634,0.9946268,0.00007222501,0.00013274056,0.0041599367],"study_design_scores_gemma":[0.000047664795,0.0011700098,0.010004876,0.000011732921,0.00003064923,0.0002782508,0.000036822385,0.0005018751,0.9822395,0.000104319086,0.005568977,0.000005287917],"about_ca_topic_score_codex":0.00028256752,"about_ca_topic_score_gemma":0.0006734716,"teacher_disagreement_score":0.0007502596,"about_ca_system_score_codex":0.00013525665,"about_ca_system_score_gemma":0.0001620441,"threshold_uncertainty_score":0.002509892},"labels":[],"label_agreement":null},{"id":"W2883558292","doi":"10.1016/j.bmc.2018.07.026","title":"Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen – A new hybrid design paradigm","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Histone deacetylase; Tamoxifen; Estrogen receptor; Antiestrogen; Histone deacetylase inhibitor; Bifunctional; In vitro; HDAC6; Biochemistry; Pharmacology; Histone; Cancer; Gene; Breast cancer; Internal medicine; Biology","score_opus":0.027916844497200808,"score_gpt":0.3177137298851036,"score_spread":0.28979688538790277,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2883558292","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7608456,0.006630335,0.1999022,0.0013845246,0.0003807067,0.00040635036,0.0004609944,0.0006881881,0.029301118],"genre_scores_gemma":[0.93830603,0.0028690507,0.049768552,0.0004912123,0.00004778437,0.00021002837,0.00025475892,0.000052701693,0.007999836],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999114,0.000013065992,0.0000064495953,0.000023015991,0.00002166491,0.00002439941],"domain_scores_gemma":[0.99995184,0.0000076074007,0.000012398925,0.0000074523887,0.000009371123,0.000011311518],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021978377,0.00038279078,0.00026783292,0.00019304706,0.00015830589,0.00041420315,0.0006494478,0.00043792743,0.001137119],"category_scores_gemma":[0.00013725866,0.0002251,0.00031190104,0.00013119707,0.00026249647,0.00053114124,0.00046790307,0.0005471913,0.0006134108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003336585,0.00012369666,0.00017763634,0.00019367,0.000045607343,0.00023006975,0.000077273966,0.0024570585,0.95619404,0.013684311,0.00043792068,0.026045132],"study_design_scores_gemma":[0.0001367621,0.0024631056,0.00040477782,0.000025084963,0.000097480035,0.000474863,0.00004041246,0.0063343486,0.95200044,0.0022673975,0.03570618,0.000049100763],"about_ca_topic_score_codex":0.0003014659,"about_ca_topic_score_gemma":0.00061241916,"teacher_disagreement_score":0.001137119,"about_ca_system_score_codex":0.0003385993,"about_ca_system_score_gemma":0.00023205385,"threshold_uncertainty_score":0.003804028},"labels":[],"label_agreement":null},{"id":"W2884582715","doi":"10.1038/s41598-018-29463-x","title":"Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"HDAC8; Mitochondrial fission; Biology; Molecular biology; Cell biology; Programmed cell death; Histone; Apoptosis; Histone deacetylase; Mitochondrion; Chemistry; Biochemistry","score_opus":0.01359927050787225,"score_gpt":0.2773962469300923,"score_spread":0.26379697642222005,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2884582715","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9914266,0.005101533,0.0017538704,0.00020837836,0.00009113749,0.000041549873,0.0002658716,0.00014091494,0.0009701475],"genre_scores_gemma":[0.99444985,0.001854698,0.0009686542,0.000082213664,0.000023926315,0.00003912636,0.0006196892,0.000016291748,0.0019456607],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998449,0.00002318654,0.000021847605,0.000027140613,0.00003762506,0.000045291697],"domain_scores_gemma":[0.9999399,0.0000054607376,0.000012770696,0.000013373776,0.000013297242,0.000015129088],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020371909,0.00033482333,0.000538258,0.00017175634,0.0001897366,0.00022423179,0.00028920636,0.0002924,0.0008977618],"category_scores_gemma":[0.00009610928,0.00016154641,0.00044022693,0.00018390045,0.00021250772,0.00015752637,0.00017574357,0.00045403757,0.00031315218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006406814,0.00009363763,0.00033434253,0.0000836302,0.000021936119,0.000050540693,0.000023001838,0.00005927578,0.99671054,0.000032774115,0.000080499434,0.0018691554],"study_design_scores_gemma":[0.00013295481,0.0012587974,0.0076026344,0.0000076024057,0.00005657319,0.0002552741,0.000055965153,0.0008606147,0.9872321,0.000029998066,0.0025008526,0.000006549203],"about_ca_topic_score_codex":0.001991353,"about_ca_topic_score_gemma":0.0020428668,"teacher_disagreement_score":0.001991353,"about_ca_system_score_codex":0.00028006273,"about_ca_system_score_gemma":0.00042714315,"threshold_uncertainty_score":0.003959477},"labels":[],"label_agreement":null},{"id":"W2884623438","doi":"10.71781/26499","title":"Auto-renouvellement et reprogrammation oncogénique dans les leucémies aiguës","year":2017,"lang":"fr","type":"dissertation","venue":"Papyrus : Institutional Repository (Université de Montréal)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Hospital Foundation; Deutsche Forschungsgemeinschaft; Université de Montréal; Canada Research Chairs; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Medicine","score_opus":0.009126664763439162,"score_gpt":0.230682309967255,"score_spread":0.22155564520381585,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2884623438","genre_codex":"empirical","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9924238,0.002457467,0.0030062315,0.00006359196,0.000013728875,0.000024513378,0.0001403629,0.000052186148,0.0018180809],"genre_scores_gemma":[0.9903814,0.0014492632,0.0020481057,0.000051448947,0.0000067382534,0.000043782158,0.00035117872,0.000016652813,0.0056513944],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998534,0.000030561197,0.000010991585,0.00003447849,0.00004115495,0.00002945588],"domain_scores_gemma":[0.99988306,0.00002673411,0.000026818327,0.000016666778,0.000018744524,0.000028045602],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547312,0.00016294385,0.00019959015,0.0003197942,0.0002233269,0.0005452008,0.000107138185,0.0003019408,0.001236485],"category_scores_gemma":[0.00018413978,0.00013289752,0.00024030033,0.00017296412,0.0002564667,0.0002909337,0.00025510273,0.00045538516,0.00032332182],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001363603,0.000019742676,0.0015773098,0.0000516095,0.000007693846,0.0001765049,0.00011884394,0.00015443291,0.99432606,0.0004422409,0.00003465162,0.0029545508],"study_design_scores_gemma":[0.00003392743,0.000756674,0.0373344,0.000023918668,0.000043350043,0.0016372114,0.00040782033,0.0017949846,0.94396794,0.00033455153,0.0136483805,0.000016863396],"about_ca_topic_score_codex":0.00092664745,"about_ca_topic_score_gemma":0.0012576022,"teacher_disagreement_score":0.001236485,"about_ca_system_score_codex":0.00025980198,"about_ca_system_score_gemma":0.00018541394,"threshold_uncertainty_score":0.0041365027},"labels":[],"label_agreement":null},{"id":"W2885083946","doi":"10.1002/cam4.1634","title":"RETRACTED: ING5‐mediated antineuroblastoma effects of suberoylanilide hydroxamic acid","year":2018,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":true,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; Takeda Oncology; National Institutes of Health; Hospital for Sick Children; National Natural Science Foundation of China","keywords":"MG132; Vorinostat; Cancer research; Histone deacetylase inhibitor; Apoptosis; Histone deacetylase; Histone H3; Chemistry; Cell cycle; Biology; Proteasome inhibitor; Histone; Biochemistry","score_opus":0.00670785593977677,"score_gpt":0.290585877089165,"score_spread":0.2838780211493882,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2885083946","genre_codex":"editorial","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.245081,0.18418105,0.008668249,0.11783259,0.33653343,0.0006004568,0.010287942,0.005663562,0.09115177],"genre_scores_gemma":[0.54820687,0.06542038,0.006227294,0.030052887,0.024251537,0.00021892936,0.009983973,0.00054555543,0.31509253],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997496,0.000025021183,0.000032638007,0.00003932985,0.00009423483,0.00005913831],"domain_scores_gemma":[0.9996057,0.00006816717,0.000050296792,0.00004231474,0.00013490448,0.000098593424],"candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00039092943,0.00054507836,0.0006017714,0.0003504082,0.00058267446,0.00047386176,0.0011904399,0.002030018,0.023989249],"category_scores_gemma":[0.00090162107,0.00017335213,0.00052448513,0.0003485649,0.00036172452,0.0007219613,0.0005325231,0.0017155338,0.0110288095],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0031666774,0.00027901953,0.002344393,0.0022372147,0.000113339695,0.014451608,0.0002730143,0.00044834483,0.21340716,0.0027930853,0.5683258,0.19216035],"study_design_scores_gemma":[0.0001787981,0.00096000684,0.0069279177,0.0001373798,0.00011298045,0.010994326,0.00021992836,0.0007804428,0.14243525,0.0008953497,0.8362951,0.00006249348],"about_ca_topic_score_codex":0.0015286593,"about_ca_topic_score_gemma":0.0019168722,"teacher_disagreement_score":0.99797,"about_ca_system_score_codex":0.0006362167,"about_ca_system_score_gemma":0.000652745,"threshold_uncertainty_score":0.08025205},"labels":[],"label_agreement":null},{"id":"W2886339606","doi":"10.1158/1538-7445.am2018-1381","title":"Abstract 1381: Targeting histone acetyltransferases to reprogram high C-MYC expressing cancers","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Esri (Canada); Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Epigenetics; Histone Acetyltransferases; Cancer research; Histone; Biology; Histone acetyltransferase; Oncogene; Chromatin; Acetylation; Cancer; Cancer cell; Molecular biology; Gene; Genetics; Cell cycle","score_opus":0.04929201030443629,"score_gpt":0.42575504007862425,"score_spread":0.37646302977418794,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2886339606","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99022585,0.0016139351,0.0039567575,0.00016547691,0.000053325926,0.00007882189,0.0010632474,0.00026155534,0.002580922],"genre_scores_gemma":[0.990306,0.0007343753,0.0040142555,0.00009429768,0.000012731011,0.000042007756,0.0011684634,0.00004164314,0.003586255],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999269,0.000007707849,0.000005714004,0.000015919955,0.000025269765,0.000018404267],"domain_scores_gemma":[0.999949,0.0000048734146,0.000013981067,0.00000632236,0.00000737618,0.00001852535],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000080777,0.00031652712,0.0002340162,0.00021541557,0.00008837503,0.00018454615,0.00018905866,0.00020956117,0.002325115],"category_scores_gemma":[0.000069956106,0.00008469854,0.00017082147,0.00019840068,0.0001363947,0.00011579516,0.00018846273,0.00044719072,0.000559259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008790982,0.000019686302,0.00008706797,0.000025546282,0.0000034810384,0.000018609382,0.0000032402747,0.00004231731,0.9977787,0.000043672353,0.00006838816,0.0018214532],"study_design_scores_gemma":[0.000026991036,0.00043712472,0.002426738,0.0000029052376,0.0000121826015,0.0001787789,0.000006366802,0.00044885383,0.99309033,0.000032360404,0.0033346207,0.0000027118067],"about_ca_topic_score_codex":0.0003399335,"about_ca_topic_score_gemma":0.0006082031,"teacher_disagreement_score":0.002325115,"about_ca_system_score_codex":0.0002572261,"about_ca_system_score_gemma":0.00017141587,"threshold_uncertainty_score":0.007778287},"labels":[],"label_agreement":null},{"id":"W2891996081","doi":"10.1200/jco.2017.35.15_suppl.6032","title":"A phase 1b/2 study of amcasertib, a first-in-class cancer stemness kinase inhibitor in advanced head and neck cancer.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Medicine; Cancer; Adverse effect; Head and neck cancer; Nausea; Response Evaluation Criteria in Solid Tumors; Internal medicine; Tolerability; Salivary gland cancer; Radiation therapy; Phases of clinical research; Oncology; Gastroenterology; Surgery; Toxicity","score_opus":0.10204527226987137,"score_gpt":0.5201254061705319,"score_spread":0.41808013390066057,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2891996081","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9723777,0.0047037276,0.0011404802,0.0011011007,0.0003272033,0.011084072,0.004087595,0.00021608183,0.0049619875],"genre_scores_gemma":[0.9568683,0.0049893353,0.003881012,0.0028234827,0.00049628975,0.011090119,0.009577839,0.000068467285,0.010205211],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9996948,0.000111124806,0.0000125767465,0.00006226603,0.000041604217,0.0000775902],"domain_scores_gemma":[0.9996445,0.000041606607,0.000060961338,0.000031051703,0.000032083863,0.00018978004],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014387929,0.001335727,0.0014169437,0.00042853472,0.0003785881,0.00079451606,0.0007302806,0.0014085727,0.006610306],"category_scores_gemma":[0.0005628043,0.0005236419,0.0010125403,0.000307955,0.00065729587,0.0006423303,0.00029267385,0.0023946408,0.0013340667],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.50659347,0.17175438,0.007912526,0.0021740166,0.001225907,0.00088542124,0.00034224775,0.0024928919,0.13625246,0.0006477392,0.02280519,0.1469138],"study_design_scores_gemma":[0.5930937,0.37896287,0.0107538495,0.000058448684,0.00035964354,0.0007559642,0.00004652928,0.0015907717,0.0063726758,0.00031612252,0.0076574464,0.000031982978],"about_ca_topic_score_codex":0.0008500743,"about_ca_topic_score_gemma":0.0024434878,"teacher_disagreement_score":0.006610306,"about_ca_system_score_codex":0.0007471303,"about_ca_system_score_gemma":0.0013752098,"threshold_uncertainty_score":0.02211368},"labels":[],"label_agreement":null},{"id":"W2892305615","doi":"10.3390/ijms19092630","title":"Histone Deacetylase Inhibitors and Diabetic Kidney Disease","year":2018,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Novo Nordisk; Kidney Foundation of Canada; Diabetes Canada; Banting and Best Diabetes Centre, University of Toronto; Heart and Stroke Foundation of Canada","keywords":"Histone deacetylase; Medicine; Epigenetics; Clinical trial; Disease; Bioinformatics; Pharmacology; Diabetes mellitus; Adverse effect; Histone deacetylase inhibitor; Repurposing; Kidney disease; Histone; Biology; Internal medicine; Endocrinology; Genetics","score_opus":0.022673545841388983,"score_gpt":0.3630696392174244,"score_spread":0.34039609337603544,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2892305615","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00013373257,0.9985227,0.00006738285,0.00031242584,0.00018441917,0.0000031655056,0.000012913162,0.000007376626,0.00075579336],"genre_scores_gemma":[0.00095752196,0.9978523,0.0001290989,0.00022986991,0.00019135013,0.0000048076245,0.00002649636,0.0000010488811,0.0006076375],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998574,0.000021727508,0.000022995331,0.000026075548,0.00005553295,0.000016257563],"domain_scores_gemma":[0.9997913,0.00008708598,0.000035887766,0.000006060232,0.000054568784,0.000025032969],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037680898,0.00053189736,0.00080049614,0.0014222005,0.00025950366,0.0006437089,0.00060633395,0.0008561172,0.0034546922],"category_scores_gemma":[0.0005867243,0.00015755609,0.00044145485,0.0011856129,0.00029355832,0.00069251435,0.00044175755,0.0016308251,0.0012765239],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010254532,0.00009351533,0.0002931559,0.00949162,0.000089507994,0.0002383045,0.00004741912,0.00021739649,0.0011281152,0.0028527274,0.033232857,0.95221287],"study_design_scores_gemma":[0.00002982949,0.00013702369,0.0012301991,0.0025149214,0.00013001046,0.0022794092,0.00004925383,0.00009377001,0.0006160245,0.0019203566,0.99098337,0.00001575695],"about_ca_topic_score_codex":0.00075427414,"about_ca_topic_score_gemma":0.00194961,"teacher_disagreement_score":0.0034546922,"about_ca_system_score_codex":0.00041517388,"about_ca_system_score_gemma":0.000764767,"threshold_uncertainty_score":0.011557102},"labels":[],"label_agreement":null},{"id":"W2892723308","doi":"10.1038/s41420-018-0103-0","title":"Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule","year":2018,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Hrvatska Zaklada za Znanost; Government of Canada","keywords":"Vorinostat; Temozolomide; Cancer research; HDAC6; Glioma; Buthionine sulfoximine; Pharmacology; Acetylation; Chemistry; Mechanism of action; Biology; Histone deacetylase; Biochemistry; Glutathione; Histone","score_opus":0.01387966389674864,"score_gpt":0.25181659003181717,"score_spread":0.23793692613506853,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2892723308","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98799384,0.0043970253,0.004519238,0.00009162788,0.000030906856,0.00005216619,0.0001296671,0.00006575245,0.0027198864],"genre_scores_gemma":[0.9950317,0.0014938668,0.0019699475,0.000032258562,0.000008023285,0.000026227002,0.00015887855,0.000003894851,0.0012751663],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999707,0.0000053979743,0.0000019649683,0.0000059445706,0.0000089321675,0.0000071418503],"domain_scores_gemma":[0.9999871,0.0000017191276,0.0000037006805,0.0000014039048,0.0000021615335,0.0000039001334],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006498484,0.00023236114,0.000124956,0.000107475236,0.00006786946,0.00011007698,0.00013416595,0.00013153542,0.0006570194],"category_scores_gemma":[0.00003151979,0.000054154,0.00012342824,0.000054316293,0.000095303156,0.000101778896,0.00009957589,0.00015501947,0.00013372493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006319833,0.000024646552,0.00007905436,0.00003919626,0.000006356368,0.000023745344,0.0000051053576,0.00007887573,0.9968148,0.00017910163,0.000024819044,0.0026611285],"study_design_scores_gemma":[0.000032411557,0.0009335855,0.001807107,0.000003947098,0.000021113281,0.0002232683,0.0000074983436,0.0007585778,0.99227726,0.000040526775,0.0038910175,0.000003650131],"about_ca_topic_score_codex":0.00025948486,"about_ca_topic_score_gemma":0.00046044326,"teacher_disagreement_score":0.0006570194,"about_ca_system_score_codex":0.00016341187,"about_ca_system_score_gemma":0.000080619546,"threshold_uncertainty_score":0.0021979809},"labels":[],"label_agreement":null},{"id":"W2896202087","doi":"10.1186/s12870-018-1454-7","title":"Characterization and subcellular localization of histone deacetylases and their roles in response to abiotic stresses in soybean","year":2018,"lang":"en","type":"article","venue":"BMC Plant Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Youth Innovation Promotion Association of the Chinese Academy of Sciences; Youth Innovation Promotion Association; Chinese Academy of Sciences; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Biology; Epigenetics; Histone; Arabidopsis; Subcellular localization; Abiotic stress; Gene; Abiotic component; Genetics; Arabidopsis thaliana; Gene expression; Function (biology); Regulation of gene expression; Cell biology","score_opus":0.012828529252109873,"score_gpt":0.27960463135304126,"score_spread":0.2667761021009314,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2896202087","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952443,0.0014781039,0.0013778213,0.00003185074,0.000006524832,0.000012675912,0.001334882,0.000022522127,0.0004911722],"genre_scores_gemma":[0.9910601,0.00067718705,0.0034308732,0.000045258766,0.0000063285443,0.000027999484,0.00369432,0.000016998718,0.0010408877],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994767,0.0000024477336,0.000005982367,0.000022354867,0.000011270713,0.00001023291],"domain_scores_gemma":[0.9999106,0.000009084733,0.000029285215,0.000007193514,0.00001912945,0.00002474258],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000098406905,0.00024262023,0.00023694163,0.0003132632,0.00015074023,0.0001779897,0.00014157392,0.00017367839,0.00041160142],"category_scores_gemma":[0.000072367635,0.00011805714,0.00037116688,0.00027994873,0.00013598576,0.0001527778,0.00016191576,0.0002071913,0.0002292777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009526501,0.0000054191582,0.0037281953,0.00005167716,0.000006391488,0.000041993284,0.00002395363,0.000044610355,0.9951237,0.000020824951,0.000012826553,0.0008451764],"study_design_scores_gemma":[0.000056638622,0.00050256366,0.46662816,0.00002448929,0.0001417723,0.0011818673,0.0003143861,0.002311507,0.5225275,0.00017322859,0.0061111907,0.00002668857],"about_ca_topic_score_codex":0.0017220818,"about_ca_topic_score_gemma":0.0022906393,"teacher_disagreement_score":0.0017220818,"about_ca_system_score_codex":0.0003007749,"about_ca_system_score_gemma":0.00019329868,"threshold_uncertainty_score":0.0034241676},"labels":[],"label_agreement":null},{"id":"W2898196508","doi":"10.3390/genes9110522","title":"Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation","year":2018,"lang":"en","type":"article","venue":"Genes","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Università degli Studi di Milano-Bicocca; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondazione Cariplo; Wellcome Trust","keywords":"Wnt signaling pathway; Catenin; Valproic Acid; Glioma; Stem cell; Cancer research; Beta-catenin; Hedgehog signaling pathway; Cell biology; Chemistry; Biology; Signal transduction; Neuroscience; Epilepsy","score_opus":0.02528529167671391,"score_gpt":0.27916531563244534,"score_spread":0.25388002395573145,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2898196508","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98251456,0.012386469,0.0008902698,0.0002198501,0.00006833696,0.000044248158,0.0017101765,0.00019252425,0.0019736493],"genre_scores_gemma":[0.9848194,0.0075857365,0.0016407206,0.0001741838,0.000017296703,0.00008800476,0.0030604005,0.000031403462,0.002582926],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999889,0.0000134884485,0.000015146132,0.000018811594,0.00003854312,0.000025066855],"domain_scores_gemma":[0.999964,0.0000049891637,0.000010281382,0.0000030632934,0.000007016604,0.000010698921],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009156173,0.00036402067,0.00046523192,0.00046875663,0.00014470542,0.0003071741,0.00016545766,0.0001983744,0.0014877766],"category_scores_gemma":[0.00009934087,0.00011920555,0.00048097828,0.00032289547,0.00014064391,0.00014064256,0.00015656678,0.00055442523,0.00025254162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012744089,0.00020794029,0.001214431,0.0004629653,0.00007211261,0.00016498116,0.000055547996,0.00035453966,0.97971743,0.0001186503,0.0005453595,0.015811766],"study_design_scores_gemma":[0.0001816565,0.0022970205,0.021080138,0.000045982597,0.00017470936,0.00042332622,0.00008779937,0.0013626929,0.96224284,0.00016504167,0.011921736,0.000017073295],"about_ca_topic_score_codex":0.0013501215,"about_ca_topic_score_gemma":0.003102912,"teacher_disagreement_score":0.0014877766,"about_ca_system_score_codex":0.00023870482,"about_ca_system_score_gemma":0.00033439652,"threshold_uncertainty_score":0.0049770474},"labels":[],"label_agreement":null},{"id":"W2900736961","doi":"10.1080/15548627.2018.1548547","title":"HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells","year":2018,"lang":"en","type":"article","venue":"Autophagy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; China Scholarship Council; Government of Canada","keywords":"Autophagy; Homeobox protein NANOG; SOX2; Biology; Cancer stem cell; LIN28; Cell biology; Cancer research; Stem cell; Cancer cell; PI3K/AKT/mTOR pathway; HDAC6; Cellular differentiation; Induced pluripotent stem cell; Embryonic stem cell; Cancer; Apoptosis; Signal transduction; Histone deacetylase; Histone; Genetics","score_opus":0.01790328370641237,"score_gpt":0.2941914063890437,"score_spread":0.2762881226826313,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2900736961","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9889747,0.004441547,0.0023003898,0.0001223951,0.00007174722,0.000029997673,0.0011045974,0.00009550631,0.0028590807],"genre_scores_gemma":[0.9933646,0.0018368192,0.0012923669,0.000073114265,0.000014949793,0.000027187829,0.0011295069,0.000019953302,0.0022415558],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999881,0.000015185002,0.000017076343,0.000031212323,0.00002796785,0.00002744857],"domain_scores_gemma":[0.99994755,0.0000047415847,0.000013895603,0.000007269941,0.000008080136,0.000018404873],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000078277684,0.00023421108,0.0002795708,0.00018444502,0.00012485869,0.00029964777,0.00015105735,0.00020258054,0.0010484722],"category_scores_gemma":[0.00006262145,0.00011340566,0.00032143106,0.00015606775,0.00019120947,0.00016468453,0.000114166796,0.00033466474,0.000432799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017238886,0.000022147888,0.00050164165,0.0000634482,0.000010985078,0.00002694944,0.000011569738,0.000047335376,0.997618,0.00011788489,0.00004739274,0.0013601966],"study_design_scores_gemma":[0.000019555591,0.00017652313,0.007516147,0.000004876396,0.000030033565,0.00016504747,0.000021840779,0.00053238386,0.98859453,0.000042420652,0.0028927051,0.000003944321],"about_ca_topic_score_codex":0.00046829347,"about_ca_topic_score_gemma":0.0009206311,"teacher_disagreement_score":0.0010484722,"about_ca_system_score_codex":0.000270063,"about_ca_system_score_gemma":0.00016551273,"threshold_uncertainty_score":0.003507495},"labels":[],"label_agreement":null},{"id":"W2901559361","doi":"10.1126/scisignal.aau7632","title":"The HDAC3–SMARCA4–miR-27a axis promotes expression of the <i>PAX3:FOXO1</i> fusion oncogene in rhabdomyosarcoma","year":2018,"lang":"en","type":"article","venue":"Science Signaling","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; St. Baldrick's Foundation","keywords":"SMARCA4; Cancer research; Rhabdomyosarcoma; FOXO1; HDAC3; Oncogene; Puma; PAX3; HDAC1; Chemistry; Biology; Medicine; Transcription factor; Cancer; Histone deacetylase; Internal medicine; Apoptosis; Gene; Pathology; Histone; Sarcoma","score_opus":0.01120640609466122,"score_gpt":0.28329725268671035,"score_spread":0.27209084659204913,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2901559361","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9907341,0.0009505926,0.0019344775,0.00017827684,0.000050858245,0.00002912205,0.00072435517,0.00023519059,0.0051629576],"genre_scores_gemma":[0.99517304,0.00031472775,0.0009801666,0.000039257262,0.000006653681,0.00001742888,0.0005559446,0.000027678312,0.002885134],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998977,0.000012341029,0.000006702397,0.000022180133,0.000033124532,0.00002798595],"domain_scores_gemma":[0.9999473,0.0000070216206,0.000017132712,0.0000062150775,0.000004030286,0.000018180994],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014323925,0.00021477978,0.00012422168,0.00022590626,0.00016345832,0.00024167573,0.00010475624,0.000105918494,0.003580653],"category_scores_gemma":[0.0000682397,0.00012512198,0.00023575091,0.000094541014,0.00022596162,0.00012212578,0.00015370552,0.00048555646,0.00069012993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001376461,0.000034721197,0.00038825272,0.000017630817,0.000007826322,0.000021707487,0.0000064559863,0.000096366035,0.99680054,0.0001292576,0.0001820229,0.0021774706],"study_design_scores_gemma":[0.000027113829,0.0003492109,0.008157817,0.0000032389214,0.000015727053,0.00016159347,0.000029759665,0.0009328566,0.9861194,0.000057709716,0.0041423715,0.0000031434677],"about_ca_topic_score_codex":0.00095657463,"about_ca_topic_score_gemma":0.0026095095,"teacher_disagreement_score":0.003580653,"about_ca_system_score_codex":0.00042286183,"about_ca_system_score_gemma":0.00030395912,"threshold_uncertainty_score":0.011978507},"labels":[],"label_agreement":null},{"id":"W29019676","doi":"10.1021/acs.jmedchem.7b00933","title":"活用すべきアメリカの日本ラジオ活動の傍受記録--第二次世界大戦期の東アジア・ラジオ関係基礎資料 (特集 メディアとプロパガンダ)","year":2003,"lang":"en","type":"article","venue":"アジア遊学","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Structural Genomics Consortium; Government of Canada; Wellcome Trust","keywords":"Computer science","score_opus":0.008776937642523014,"score_gpt":0.2705501308946878,"score_spread":0.2617731932521648,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W29019676","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8317882,0.0377456,0.062283434,0.003450927,0.0009255267,0.00035550832,0.0014776291,0.0006933732,0.061279856],"genre_scores_gemma":[0.92440325,0.009670206,0.0322774,0.00038585768,0.00012547088,0.000072479976,0.0010082459,0.00005106061,0.032005984],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998876,0.000013670848,0.000007479307,0.000025893673,0.000039787108,0.000025511195],"domain_scores_gemma":[0.9998925,0.00002268574,0.000028547955,0.000008778169,0.00002033618,0.00002705992],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027479295,0.0002922152,0.00024757066,0.00012572031,0.00034391388,0.0005773745,0.00017577641,0.00030276345,0.0039234497],"category_scores_gemma":[0.0002139971,0.00017709265,0.00025674363,0.00012837784,0.00045369225,0.0003796559,0.00016604354,0.0007726063,0.002413137],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004991684,0.0001603662,0.0016147143,0.00026259915,0.00002885673,0.00030538999,0.000059995204,0.0010657257,0.9383304,0.008275214,0.001688868,0.047708705],"study_design_scores_gemma":[0.000031783282,0.00031131448,0.0017125874,0.00001101094,0.000018135337,0.0004620356,0.000034827168,0.0010653248,0.9713793,0.0009627679,0.024000036,0.000010884289],"about_ca_topic_score_codex":0.00063063344,"about_ca_topic_score_gemma":0.0014001708,"teacher_disagreement_score":0.0039234497,"about_ca_system_score_codex":0.0006167532,"about_ca_system_score_gemma":0.0003946029,"threshold_uncertainty_score":0.013125241},"labels":[],"label_agreement":null},{"id":"W2902508335","doi":"10.1002/jcp.27873","title":"HDAC10 upregulation contributes to interleukin 1β‐mediated inflammatory activation of synovium‐derived mesenchymal stem cells in temporomandibular joint","year":2018,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"CAE (Canada)","funders":"Guangdong Medical Research Foundation; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Mesenchymal stem cell; Downregulation and upregulation; Temporomandibular joint; Inflammation; Medicine; Cell biology; Orthodontics; Biology; Immunology; Pathology; Genetics","score_opus":0.009609354672310538,"score_gpt":0.2409438982806259,"score_spread":0.23133454360831537,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2902508335","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95711124,0.027673932,0.0067249276,0.00053022866,0.00036831622,0.00012137502,0.001266554,0.00023359217,0.0059698485],"genre_scores_gemma":[0.9844922,0.009187828,0.0015670601,0.0001275226,0.00005552686,0.00006927321,0.00090627605,0.000018371966,0.0035758028],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988115,0.000013833173,0.000012549925,0.000023964574,0.00003268046,0.000035842317],"domain_scores_gemma":[0.999966,0.0000027976855,0.000009617728,0.0000034457044,0.0000061145893,0.0000119913],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012273835,0.00053205405,0.00034388123,0.00022977887,0.00019323545,0.00027852578,0.000154257,0.0002400608,0.0020287482],"category_scores_gemma":[0.000052864692,0.00019622323,0.0004876695,0.00021570803,0.00028581073,0.00016535625,0.00018800776,0.00051351526,0.0006843465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013445473,0.00002116534,0.00026075792,0.00012995511,0.000008362009,0.00007816944,0.000014069941,0.00002248651,0.997279,0.000055130615,0.00007788236,0.0019185827],"study_design_scores_gemma":[0.000076823686,0.0004310458,0.02172456,0.000024989235,0.00008729673,0.00059306435,0.00011478966,0.0005090689,0.96710557,0.000096668395,0.009226469,0.000009713893],"about_ca_topic_score_codex":0.0008947772,"about_ca_topic_score_gemma":0.0017974217,"teacher_disagreement_score":0.0020287482,"about_ca_system_score_codex":0.00035352167,"about_ca_system_score_gemma":0.00035317015,"threshold_uncertainty_score":0.0067867637},"labels":[],"label_agreement":null},{"id":"W2904237875","doi":"10.1038/s41593-018-0291-1","title":"Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains","year":2018,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pacific Centre for Reproductive Medicine; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Epigenome; Chromatin; Histone; Neuroscience; Biology; Epigenetics; PIN1; Acetylation; Chromatin remodeling; Alzheimer's disease; Cell biology; Genetics; Disease; Gene expression; Medicine; DNA methylation; Pathology; Gene","score_opus":0.014352322626982116,"score_gpt":0.3306554009936748,"score_spread":0.3163030783666927,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2904237875","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9958616,0.001483196,0.00067207345,0.00010537398,0.000011948609,0.0000038254752,0.0014558415,0.000028343315,0.0003778487],"genre_scores_gemma":[0.99778533,0.0004217151,0.00022770542,0.00007766239,0.000013304245,0.000005090759,0.0010888303,0.000011917571,0.00036845333],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9998486,0.000017025579,0.000009012058,0.00008229612,0.000014853853,0.000028053519],"domain_scores_gemma":[0.999734,0.000069008966,0.000090081434,0.000033785273,0.000025527646,0.00004766514],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025363473,0.000207474,0.00041704037,0.00063135836,0.00020837446,0.00037352776,0.00019307855,0.0002420193,0.0013489826],"category_scores_gemma":[0.00041374698,0.00018441422,0.00051111245,0.0007568384,0.00021072649,0.00023087383,0.00042182353,0.0003466949,0.00014125084],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022491482,0.000088705754,0.7215429,0.00020528119,0.0028652581,0.0005705465,0.0004199614,0.00065226527,0.24010634,0.00050063885,0.0013664833,0.029432403],"study_design_scores_gemma":[0.0000070058204,0.000034012428,0.99711597,0.0000032318906,0.000222675,0.00018581892,0.000061996696,0.00020888197,0.0014599136,0.00014677033,0.000548031,0.000005592147],"about_ca_topic_score_codex":0.0020096449,"about_ca_topic_score_gemma":0.0047592977,"teacher_disagreement_score":0.0020096449,"about_ca_system_score_codex":0.00013119658,"about_ca_system_score_gemma":0.00015994716,"threshold_uncertainty_score":0.004512787},"labels":[],"label_agreement":null},{"id":"W2908798408","doi":"10.1101/521393","title":"HDAC and MAPK/ERK Inhibitors Cooperate to Reduce Viability and Stemness in Medulloblastoma","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society Research Institute; National Institutes of Health; Fundação Instituto de Pesquisas Econômicas; Terry Fox Research Institute; Hospital de Clínicas de Porto Alegre; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Brain Tumour Foundation of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Genome British Columbia; Ontario Institute for Cancer Research; American Brain Tumor Association; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Genome Canada","keywords":"MAPK/ERK pathway; Homeobox protein NANOG; BMI1; Cancer stem cell; Cancer research; Biology; Histone deacetylase; SOX2; Embryonic stem cell; Stem cell; RHOA; Neural stem cell; Neurosphere; Cell biology; Signal transduction; Histone; Genetics; Adult stem cell; Induced pluripotent stem cell","score_opus":0.009572731179865509,"score_gpt":0.24450077479887852,"score_spread":0.234928043619013,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2908798408","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9946116,0.0024588292,0.0008797788,0.00007294408,0.0000321735,0.00003110361,0.00034251303,0.00009753395,0.0014735132],"genre_scores_gemma":[0.99532074,0.0012208985,0.0010530952,0.000024804873,0.000008800697,0.00003294908,0.00047845673,0.000015031794,0.0018452897],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994063,0.000009297561,0.000006112755,0.000010259436,0.0000168385,0.000016957269],"domain_scores_gemma":[0.9999769,0.000003931469,0.000005038468,0.000002682359,0.0000025966353,0.000008850532],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000093728915,0.00033970524,0.00025462135,0.00023279023,0.00010647252,0.00014083083,0.00018053355,0.00010985509,0.0010320329],"category_scores_gemma":[0.00006000237,0.000097376076,0.00020135712,0.00010645505,0.00011144716,0.00009467544,0.000116122144,0.00032140038,0.00019156368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004929499,0.00012498446,0.00046449632,0.000053392043,0.00001612682,0.000033452598,0.000009460626,0.00013517482,0.994041,0.00007920054,0.00010950572,0.004440185],"study_design_scores_gemma":[0.00008995702,0.0010266887,0.009148081,0.0000054281095,0.000039749368,0.00020228329,0.000018828721,0.0013373471,0.9849819,0.000040322037,0.0031062209,0.0000031954244],"about_ca_topic_score_codex":0.00096626574,"about_ca_topic_score_gemma":0.002522788,"teacher_disagreement_score":0.0010320329,"about_ca_system_score_codex":0.00025744297,"about_ca_system_score_gemma":0.00017437615,"threshold_uncertainty_score":0.0034524798},"labels":[],"label_agreement":null},{"id":"W2909421659","doi":"10.1139/bcb-2018-0208","title":"Protein kinase A mediates novel serine-584 phosphorylation of HDAC4","year":2019,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Department of Science and Technology, Ministry of Science and Technology, India; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Phosphorylation; HDAC4; Protein kinase A; Biology; Cell biology; Molecular biology; SUMO protein; Serine; Kinase; Chemistry; Biochemistry; Histone; Histone deacetylase; Ubiquitin","score_opus":0.006358883860632942,"score_gpt":0.2352507120996108,"score_spread":0.22889182823897786,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2909421659","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99392587,0.0013426393,0.0026715822,0.0001119284,0.00005708168,0.000019408993,0.00045375075,0.000058887472,0.0013589234],"genre_scores_gemma":[0.9942894,0.0008994381,0.0016817832,0.000053291264,0.000018976449,0.000018950932,0.001055065,0.000020339761,0.0019627959],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999915,0.000008733809,0.000006336475,0.000028484039,0.000018616744,0.00002283522],"domain_scores_gemma":[0.99994266,0.0000061309943,0.000024067032,0.000005950235,0.000006218606,0.000014940739],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000093297494,0.0004651776,0.00019938493,0.00014589957,0.00016949672,0.00021681077,0.00019037374,0.00019248335,0.0021495936],"category_scores_gemma":[0.00010469772,0.00014371534,0.00045482462,0.00011193025,0.00017602631,0.00014654918,0.00017886245,0.00033110846,0.0008716929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014025609,0.000019880292,0.00041480802,0.000051594332,0.000011349507,0.00007144013,0.000006082368,0.000078482444,0.9981337,0.00010333229,0.000053433472,0.0009156585],"study_design_scores_gemma":[0.000029668052,0.00014880797,0.009825355,0.0000064288383,0.000018570961,0.00039138997,0.000022440798,0.0014677236,0.98567176,0.00009968519,0.0023117976,0.000006437765],"about_ca_topic_score_codex":0.00058768044,"about_ca_topic_score_gemma":0.000695535,"teacher_disagreement_score":0.0021495936,"about_ca_system_score_codex":0.00029904017,"about_ca_system_score_gemma":0.00020405483,"threshold_uncertainty_score":0.007191062},"labels":[],"label_agreement":null},{"id":"W2912582226","doi":"10.2174/1568026619666190125145110","title":"Research Advances in the Use of Histone Deacetylase Inhibitors for Epigenetic Targeting of Cancer","year":2019,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Scientific Research Funds of Jilin Province of Health and Family Planning Commission; Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province; Department of Science and Technology of Jilin Province; Education Department of Jilin Province","keywords":"Epigenetics; Histone deacetylase; Histone; Epigenetic therapy; Cancer; Cancer epigenetics; Chromatin remodeling; Cancer research; Bioinformatics; Chromatin; Vorinostat; Medicine; Computational biology; Biology; DNA methylation; Gene expression; Gene; Genetics; Histone methyltransferase","score_opus":0.1787180327933119,"score_gpt":0.5138313555563935,"score_spread":0.3351133227630816,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2912582226","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00037317027,0.99635446,0.00048637984,0.0002806542,0.00020352547,0.000009923633,0.000029449422,0.000015785721,0.002246629],"genre_scores_gemma":[0.0015628297,0.997026,0.00038687803,0.00015700204,0.0001248389,0.000007258475,0.00003975964,0.000002365037,0.0006930572],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99983203,0.000026153733,0.000018665345,0.00003766565,0.00006666887,0.000018727646],"domain_scores_gemma":[0.99976355,0.00010953175,0.000031999458,0.000011717608,0.00005740917,0.000025794441],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005430477,0.000729721,0.00087243825,0.0022056794,0.00027188644,0.00065046333,0.0006266931,0.00067262043,0.0048487997],"category_scores_gemma":[0.000489598,0.00027164962,0.0005915276,0.0016795923,0.00040567317,0.0010455442,0.0006149386,0.0017693014,0.002279902],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009806224,0.00013847706,0.00018799645,0.015154979,0.0001020254,0.00026221303,0.000071199,0.00059153396,0.010081898,0.0071394173,0.017781012,0.94839126],"study_design_scores_gemma":[0.000031120504,0.00023514986,0.0008180003,0.0013619337,0.00014408528,0.0012868134,0.000037159094,0.00018887453,0.0033880766,0.0023824074,0.9901025,0.000023811499],"about_ca_topic_score_codex":0.00056319655,"about_ca_topic_score_gemma":0.0012026357,"teacher_disagreement_score":0.0048487997,"about_ca_system_score_codex":0.00046599488,"about_ca_system_score_gemma":0.0007285852,"threshold_uncertainty_score":0.016220868},"labels":[],"label_agreement":null},{"id":"W2912634091","doi":"10.1016/j.isci.2019.02.008","title":"HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia; Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Environmental Health Sciences; Canadian Cancer Society Research Institute; National Cancer Institute; National Institutes of Health; Celgene; St. Baldrick's Foundation; Damon Runyon Cancer Research Foundation","keywords":"Acetylation; Ubiquitin; Ubiquitin ligase; Histone deacetylase 2; P300-CBP Transcription Factors; Mdm2; Histone; Chemistry; Cell biology; Bromodomain; Lysine; Histone deacetylase; Biology; Biochemistry; Histone Acetyltransferases; DNA; Apoptosis; Amino acid","score_opus":0.011865313369826205,"score_gpt":0.26861818081435557,"score_spread":0.25675286744452935,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2912634091","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9644995,0.014681179,0.0070534074,0.00047702526,0.00016643738,0.00003956629,0.000672437,0.00021188217,0.012198572],"genre_scores_gemma":[0.99303585,0.0019076251,0.0006856989,0.00004955341,0.000024316292,0.000013486448,0.00025869074,0.0000114250115,0.0040132506],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998853,0.000018203635,0.0000066444386,0.00002402937,0.00002603021,0.000039790288],"domain_scores_gemma":[0.999964,0.0000029138803,0.000009638607,0.0000040058558,0.0000054284787,0.000013995845],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013006269,0.0003912415,0.00021159765,0.00017826093,0.00022649398,0.00043679425,0.00017826908,0.00020536278,0.0021168755],"category_scores_gemma":[0.00007042773,0.00013557894,0.00021769009,0.00014695723,0.00021790086,0.00025291392,0.00021729773,0.00035312958,0.0005458702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020877535,0.000030144365,0.0008300674,0.000042208805,0.000009337718,0.000115501716,0.000013611889,0.00012206198,0.99400043,0.0007773567,0.000215304,0.0036352172],"study_design_scores_gemma":[0.00003320072,0.00017225282,0.014543387,0.000009088645,0.000022373817,0.0004598776,0.0000687542,0.0015446123,0.9720433,0.00032457107,0.010771159,0.0000073981478],"about_ca_topic_score_codex":0.00038729777,"about_ca_topic_score_gemma":0.0011000648,"teacher_disagreement_score":0.0021168755,"about_ca_system_score_codex":0.00040892474,"about_ca_system_score_gemma":0.00021307296,"threshold_uncertainty_score":0.0070816875},"labels":[],"label_agreement":null},{"id":"W2913710712","doi":"10.1002/chin.200208094","title":"ChemInform Abstract: Design and Synthesis of a Novel Class of Histone Deacetylase Inhibitors.","year":2002,"lang":"en","type":"article","venue":"ChemInform","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Association of Nurses in Oncology","funders":"","keywords":"Chemistry; Histone deacetylase; Class (philosophy); Combinatorial chemistry; Histone; Nanotechnology; Computational biology; Biochemistry; Artificial intelligence; Computer science; DNA","score_opus":0.023614739259367773,"score_gpt":0.27570665431232594,"score_spread":0.25209191505295814,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2913710712","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.31534716,0.117478475,0.29304308,0.005667115,0.006837963,0.0051420243,0.022183735,0.0105762305,0.22372428],"genre_scores_gemma":[0.61459893,0.09918068,0.11688485,0.0030467762,0.00073831587,0.0013726639,0.019479176,0.0007070593,0.14399149],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985385,0.000012620273,0.000011363691,0.000032266915,0.000054043718,0.00003595428],"domain_scores_gemma":[0.9999329,0.0000035894714,0.000010960448,0.00000455231,0.0000123810605,0.00003558908],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030271037,0.0012250148,0.0006474248,0.00054266525,0.00034189687,0.00064700656,0.00083529565,0.0004751049,0.009231351],"category_scores_gemma":[0.0001790133,0.0004384429,0.0005056098,0.0004962518,0.0002265119,0.0005559725,0.00038083817,0.000972903,0.005530274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014768692,0.00078119035,0.00027078646,0.0018541374,0.00019391195,0.00051975955,0.00012005195,0.0039604134,0.7479911,0.008965296,0.04720093,0.18666542],"study_design_scores_gemma":[0.0010192837,0.0022602272,0.00072152755,0.00009365223,0.00019652557,0.0007539093,0.00002414975,0.0030961111,0.7047097,0.0010113737,0.28603023,0.00008332144],"about_ca_topic_score_codex":0.0010717716,"about_ca_topic_score_gemma":0.0028683706,"teacher_disagreement_score":0.009231351,"about_ca_system_score_codex":0.0006995311,"about_ca_system_score_gemma":0.0010706037,"threshold_uncertainty_score":0.030882},"labels":[],"label_agreement":null},{"id":"W2914594525","doi":"10.1182/blood-2018-99-110869","title":"The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Supercomplex Formation and Represents a New Therapeutic Target for AML","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Gene knockdown; Haematopoiesis; Biology; Stem cell; Myeloid; Myeloid leukemia; Respiratory chain; Cancer research; Leukemia; Cell culture; Mitochondrion; Molecular biology; Cell biology; Immunology; Genetics","score_opus":0.021427361657703207,"score_gpt":0.2818912512840969,"score_spread":0.2604638896263937,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2914594525","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9545492,0.02379657,0.014588007,0.0015960577,0.0001558066,0.00013059948,0.00085033337,0.0004294174,0.0039039662],"genre_scores_gemma":[0.98676956,0.0061320965,0.0038002918,0.00018763811,0.000034239027,0.00003992003,0.0005131394,0.000022868006,0.0025003138],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999579,0.000005573801,0.0000045114175,0.0000103966695,0.000013234022,0.000008288008],"domain_scores_gemma":[0.99995565,0.0000062054164,0.000017612447,0.0000037467355,0.000007690229,0.000009059628],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112641734,0.00020641048,0.00017018757,0.00015728651,0.00008382393,0.000255952,0.00013658719,0.00017472617,0.00079858874],"category_scores_gemma":[0.00006728388,0.000052414165,0.00013276211,0.000096219424,0.00015615618,0.00016087099,0.00018033209,0.0003757798,0.00020457282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015229879,0.00002857985,0.00051906426,0.00007459678,0.000009624295,0.000080918915,0.000008488187,0.00013981709,0.99032825,0.0002155008,0.00031444328,0.008128364],"study_design_scores_gemma":[0.00009256822,0.0005723806,0.0054476727,0.000018212246,0.00004715741,0.0009555293,0.00002878565,0.0019902533,0.9754346,0.00034058117,0.015065194,0.0000071115473],"about_ca_topic_score_codex":0.00027389007,"about_ca_topic_score_gemma":0.0005919063,"teacher_disagreement_score":0.00079858874,"about_ca_system_score_codex":0.00037843437,"about_ca_system_score_gemma":0.00014338848,"threshold_uncertainty_score":0.002745688},"labels":[],"label_agreement":null},{"id":"W2916749940","doi":"10.1074/jbc.ra118.006051","title":"A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Acetylation; Biology; Histone; Acetyltransferase; Biochemistry; Histone acetyltransferase; P300-CBP Transcription Factors; Histone deacetylase; Histone Acetyltransferases; Fusion protein; Non-histone protein; Gene; Recombinant DNA","score_opus":0.013288397533876277,"score_gpt":0.2848393476063172,"score_spread":0.2715509500724409,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2916749940","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9733147,0.0014371198,0.022647347,0.00005796096,0.000048157985,0.000050149833,0.0007102375,0.00007968394,0.001654682],"genre_scores_gemma":[0.9663557,0.0008802057,0.026720656,0.00008021881,0.000009704463,0.00005071892,0.0028363233,0.00007440446,0.0029921199],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997639,0.00003158781,0.00002115978,0.000062586885,0.00009171093,0.0000289774],"domain_scores_gemma":[0.99984145,0.000027967195,0.000052806798,0.000021523341,0.000024384628,0.000031780935],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019569298,0.00039352343,0.00020773291,0.00016957706,0.00013758232,0.0002255763,0.00031195456,0.00028067382,0.00072794844],"category_scores_gemma":[0.0001737006,0.00015370626,0.00023208171,0.00024767595,0.00012608733,0.000181918,0.00020113203,0.00043504796,0.00039442783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000022816697,0.000007276301,0.00008553369,0.000016526981,0.0000030243832,0.00001424761,0.0000054250772,0.000067788475,0.9993374,0.000055596618,0.0000073966044,0.0003769602],"study_design_scores_gemma":[0.0000024135193,0.000070222624,0.00072212087,0.0000023642094,0.000005326599,0.00008071028,0.000008963926,0.00060980656,0.9970536,0.00002010318,0.0014216773,0.0000027184392],"about_ca_topic_score_codex":0.00053960894,"about_ca_topic_score_gemma":0.0010063417,"teacher_disagreement_score":0.00072794844,"about_ca_system_score_codex":0.00040069778,"about_ca_system_score_gemma":0.00016322454,"threshold_uncertainty_score":0.0029072165},"labels":[],"label_agreement":null},{"id":"W2917853179","doi":"10.1021/acs.jmedchem.8b01957","title":"Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary; McMaster University; University of Toronto","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Leukemia and Lymphoma Society of Canada; University of Toronto; Stem Cell Network; National Center for Advancing Translational Sciences; Alberta Innovates - Health Solutions; Mitacs; Indiana Clinical and Translational Sciences Institute","keywords":"Pancreatic cancer; In vivo; Histone deacetylase; Cancer research; Pharmacology; Cancer; Chemistry; Hydroxamic acid; HDAC6; Medicine; Internal medicine; Histone; Biology; Biochemistry","score_opus":0.014035110602084056,"score_gpt":0.27722449191749776,"score_spread":0.2631893813154137,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2917853179","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97246504,0.0051902668,0.014279436,0.00027437884,0.00006258809,0.00032496062,0.0037325434,0.00021623028,0.0034545066],"genre_scores_gemma":[0.97253644,0.003913209,0.012300514,0.00014431514,0.000021399308,0.00010231153,0.00743465,0.00003833793,0.0035088053],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998841,0.000011006829,0.000010555466,0.000022177714,0.00004485853,0.000027261394],"domain_scores_gemma":[0.9999262,0.000005589391,0.000014669148,0.0000066740768,0.000013436222,0.000033345063],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020586976,0.00043197273,0.00035751043,0.00032335692,0.00012947444,0.00024391098,0.0002604674,0.00023312186,0.00056466344],"category_scores_gemma":[0.00009353927,0.00016007334,0.00033876218,0.00024618872,0.00017240315,0.00022092463,0.00008170985,0.00053124654,0.0002822902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009068229,0.00005533304,0.00014219967,0.0000301836,0.0000059993054,0.000028048775,0.000006576255,0.00013122955,0.99794024,0.00005833442,0.000062750194,0.0014484536],"study_design_scores_gemma":[0.0000576717,0.0014764476,0.0050507435,0.000005419359,0.00004104015,0.00037711614,0.000018337878,0.0015716859,0.98602444,0.000029896295,0.0053395983,0.000007601648],"about_ca_topic_score_codex":0.0018674247,"about_ca_topic_score_gemma":0.0027927414,"teacher_disagreement_score":0.0018674247,"about_ca_system_score_codex":0.00036353845,"about_ca_system_score_gemma":0.0004275381,"threshold_uncertainty_score":0.0037130713},"labels":[],"label_agreement":null},{"id":"W2921322168","doi":"10.1016/s0277-9536(03)00324-1","title":"Dying &amp; death in Canada","year":2003,"lang":"en","type":"article","venue":"Social Science & Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Medicine","score_opus":0.023162797035949815,"score_gpt":0.3254138101314867,"score_spread":0.30225101309553687,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2921322168","genre_codex":"other","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.22303158,0.027298398,0.0009781831,0.2908757,0.0039179428,0.0002790383,0.020376105,0.00020417389,0.43303892],"genre_scores_gemma":[0.73147917,0.019079702,0.00092099956,0.019063314,0.0005830288,0.00009888373,0.00230513,0.00009635047,0.22637352],"study_design_codex":"not_applicable","study_design_gemma":"observational","domain_scores_codex":[0.9988764,0.00007286458,0.00003386192,0.00006338269,0.0002388534,0.00071462995],"domain_scores_gemma":[0.9945417,0.0003220124,0.00033783884,0.000054815686,0.0015741396,0.0031695177],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00070116663,0.00023188973,0.00039070423,0.001557734,0.013774589,0.0031165192,0.0014625709,0.0019135126,0.037822954],"category_scores_gemma":[0.0037605336,0.00020804968,0.00043485677,0.0039735567,0.0020118083,0.0008897239,0.0022381255,0.004533385,0.0013343813],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044003973,0.00016301963,0.14740892,0.0006094583,0.000071548246,0.0026538451,0.0086577395,0.0010940338,0.00023228393,0.11299314,0.56868833,0.15698756],"study_design_scores_gemma":[0.00012272909,0.00007837646,0.25612566,0.001051484,0.000082418184,0.00092840183,0.02911342,0.0009932268,0.00026511442,0.010429262,0.7006893,0.00012065352],"about_ca_topic_score_codex":0.99694866,"about_ca_topic_score_gemma":0.99908566,"teacher_disagreement_score":0.09053666,"about_ca_system_score_codex":0.09053666,"about_ca_system_score_gemma":0.19184732,"threshold_uncertainty_score":0.65689254},"labels":[],"label_agreement":null},{"id":"W2922149081","doi":"10.1042/bst028a250c","title":"Structure - Function Studies of the Yeast Histone Deacetylase Hos3p","year":2000,"lang":"en","type":"article","venue":"Biochemical Society Transactions","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Yeast; Histone deacetylase; HDAC11; HDAC10; Function (biology); Chemistry; Histone; Cell biology; Biochemistry; Biology; DNA","score_opus":0.012394378141223902,"score_gpt":0.2864963305134414,"score_spread":0.2741019523722175,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2922149081","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96673554,0.020266557,0.0039478363,0.0013961087,0.00030219948,0.000027837834,0.0016755206,0.0001874169,0.005461063],"genre_scores_gemma":[0.9763267,0.0068444894,0.0023373442,0.00017938462,0.000024586674,0.000010313395,0.0061305673,0.00006095192,0.008085711],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998845,0.000014381802,0.000007187703,0.000020167585,0.00005223775,0.000021602495],"domain_scores_gemma":[0.9999087,0.000013763652,0.000014383578,0.0000055387513,0.000031957105,0.000025652016],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025076492,0.00049872836,0.00034962123,0.00020950123,0.0004226513,0.00048765325,0.00046072577,0.00050564884,0.0028563752],"category_scores_gemma":[0.00033487345,0.00021931593,0.00053623243,0.0005547937,0.00022965555,0.00036679723,0.00022568731,0.0007644402,0.00141362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0025330517,0.00027311742,0.004718009,0.00073509227,0.00014742604,0.0012056225,0.00040312702,0.0049278038,0.9433666,0.0032341839,0.008939718,0.029516267],"study_design_scores_gemma":[0.00018910633,0.0010880745,0.02577239,0.00005153949,0.00016714584,0.0017016779,0.00048221098,0.011669351,0.9108952,0.0012942781,0.046623617,0.000065468674],"about_ca_topic_score_codex":0.007802042,"about_ca_topic_score_gemma":0.0069338134,"teacher_disagreement_score":0.007802042,"about_ca_system_score_codex":0.0013913321,"about_ca_system_score_gemma":0.000513448,"threshold_uncertainty_score":0.015513241},"labels":[],"label_agreement":null},{"id":"W2923104374","doi":"10.1158/0008-5472.can-18-3704","title":"Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"PRC2; Epigenomics; Cancer research; Biology; Histone deacetylase; Histone H3; Carcinogenesis; Nerve sheath neoplasm; DNA methylation; Histone; Epigenetics; Cell biology; Malignant peripheral nerve sheath tumor; Genetics; Cancer; Gene expression","score_opus":0.032962211055523265,"score_gpt":0.3531052575641115,"score_spread":0.3201430465085882,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2923104374","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9977689,0.00049672945,0.00086750044,0.000035987425,0.000007700102,0.000011572349,0.00023162737,0.000044907727,0.0005350112],"genre_scores_gemma":[0.9985783,0.00017762084,0.00027577335,0.000016826645,0.0000021753056,0.000010168269,0.00024898912,0.0000066793204,0.00068356754],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999206,0.000008624239,0.000006982044,0.000019546811,0.000024789144,0.000019401985],"domain_scores_gemma":[0.9999236,0.000011997575,0.000026735908,0.000012762136,0.0000064768806,0.000018458202],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006985251,0.00016328649,0.00014960014,0.00016709656,0.00007689499,0.0001936381,0.00010438908,0.0001462729,0.0011414237],"category_scores_gemma":[0.000107076805,0.00009063976,0.00013922458,0.000118511234,0.00014947337,0.00011747476,0.00017362092,0.00033894033,0.0001784589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000043993005,0.000008861599,0.00037318937,0.000007810987,0.0000041261305,0.00004187826,0.0000048045604,0.000031280262,0.99882203,0.00002861323,0.000014041888,0.00061930105],"study_design_scores_gemma":[0.000009899232,0.00033132767,0.027969895,0.0000027041915,0.00002002148,0.00078120513,0.00003787446,0.0010649089,0.9682603,0.00006931805,0.001449076,0.0000035220874],"about_ca_topic_score_codex":0.0003355212,"about_ca_topic_score_gemma":0.00047540752,"teacher_disagreement_score":0.0011414237,"about_ca_system_score_codex":0.00014708367,"about_ca_system_score_gemma":0.000083348794,"threshold_uncertainty_score":0.0038184524},"labels":[],"label_agreement":null},{"id":"W2936827664","doi":"10.1074/jbc.ra118.007006","title":"HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; University of Colorado Denver; School of Medicine, New York University; National Institutes of Health; Government of Canada; Deutsches Zentrum für Herz-Kreislaufforschung; National Institute of General Medical Sciences; American Heart Association","keywords":"Histone deacetylase 5; Histone deacetylase; Gene knockdown; Cell biology; Transcription factor; Biology; Ectopic expression; Histone acetyltransferase; Oxidative stress; Histone; Biochemistry; Gene","score_opus":0.013556472377457059,"score_gpt":0.2685922117651655,"score_spread":0.25503573938770846,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2936827664","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9905591,0.0026116425,0.0033080895,0.00015157941,0.00007735402,0.000026533682,0.0004241429,0.00014128041,0.0027002005],"genre_scores_gemma":[0.99488056,0.0008990837,0.0013295341,0.000062958025,0.000014839155,0.000016909182,0.0005125791,0.00001488001,0.002268684],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998568,0.000021124846,0.0000204944,0.000031990454,0.000034720804,0.000034826357],"domain_scores_gemma":[0.99992967,0.000008310662,0.000020642643,0.0000110762185,0.0000064483593,0.00002383511],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017945164,0.00033024687,0.00029885434,0.00015953711,0.00013513083,0.00023503831,0.00021410568,0.00017838812,0.0013847334],"category_scores_gemma":[0.00008733536,0.000120863806,0.00023839143,0.00012477479,0.00020339944,0.00011602507,0.00014284164,0.00044822032,0.0003211682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012605432,0.00003143371,0.00014223243,0.000034208748,0.0000076535225,0.000016501002,0.0000047571957,0.000030414867,0.9981816,0.00006430542,0.000042791286,0.0013181757],"study_design_scores_gemma":[0.000017372071,0.00029230674,0.0019622515,0.0000032076346,0.000012774192,0.000079710124,0.000011354561,0.00033398814,0.9958905,0.000014512431,0.0013802999,0.0000016047512],"about_ca_topic_score_codex":0.00052885705,"about_ca_topic_score_gemma":0.0011903516,"teacher_disagreement_score":0.0013847334,"about_ca_system_score_codex":0.00025071736,"about_ca_system_score_gemma":0.00023539737,"threshold_uncertainty_score":0.0046324134},"labels":[],"label_agreement":null},{"id":"W2939069517","doi":"10.1016/j.yjmcc.2019.04.003","title":"Histone deacetylases in cardiovascular and metabolic diseases","year":2019,"lang":"en","type":"review","venue":"Journal of Molecular and Cellular Cardiology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Shine","keywords":"Epigenetics; Histone; Gene isoform; Biology; Acetylation; Enhancer; Cell biology; Transcription factor; Gene; Genetics","score_opus":0.01925485902248742,"score_gpt":0.2992343002127671,"score_spread":0.2799794411902797,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2939069517","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000041196425,0.99862325,0.00013998231,0.0002611535,0.0004290445,0.0000032144799,0.00001254253,0.000007751667,0.00048179532],"genre_scores_gemma":[0.00045647036,0.9978745,0.00023058378,0.0002538781,0.0005620213,0.000006104652,0.000022709757,0.0000013303181,0.000592507],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998393,0.000024560177,0.000021515662,0.000031461394,0.000062006504,0.000021133787],"domain_scores_gemma":[0.99973136,0.000108348955,0.000040388437,0.000010198696,0.00006954108,0.000040059804],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007332632,0.0014424435,0.0018770985,0.0019236249,0.00028754192,0.00097195705,0.0010698197,0.0013022145,0.0030112092],"category_scores_gemma":[0.00076834747,0.00037053722,0.00042916532,0.00227054,0.00063454924,0.001084779,0.00073726487,0.0028873454,0.002369078],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020398006,0.00010067254,0.0001355187,0.00977727,0.000118194745,0.00019407993,0.00003126027,0.00047644952,0.001891464,0.0037628917,0.075580314,0.90772796],"study_design_scores_gemma":[0.00007703559,0.00011307818,0.00064514024,0.001784891,0.0001913491,0.0007255873,0.00003503717,0.00015550462,0.00044211498,0.00276928,0.9930386,0.000022410062],"about_ca_topic_score_codex":0.0010709439,"about_ca_topic_score_gemma":0.0026319758,"teacher_disagreement_score":0.0030112092,"about_ca_system_score_codex":0.0006924308,"about_ca_system_score_gemma":0.0010317493,"threshold_uncertainty_score":0.010073483},"labels":[],"label_agreement":null},{"id":"W2943549050","doi":"10.1093/pm/pnz067","title":"The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial","year":2019,"lang":"en","type":"article","venue":"Pain Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Perioperative; Anesthesia; Placebo; Randomized controlled trial; Amputation; Brief Pain Inventory; Visual analogue scale; Pain medicine; Chronic pain; Surgery; Physical therapy; Anesthesiology","score_opus":0.05255686669686859,"score_gpt":0.3732484741260391,"score_spread":0.3206916074291705,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2943549050","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9723051,0.021101125,0.0005481013,0.0008226136,0.0006352311,0.0025094268,0.0007028973,0.00006419676,0.0013113829],"genre_scores_gemma":[0.9814415,0.0104490975,0.0013722694,0.0008385947,0.0008189133,0.003304787,0.00060480274,0.000013112154,0.001157078],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99848783,0.00094695296,0.00015486071,0.00016888516,0.000119434044,0.00012202871],"domain_scores_gemma":[0.998396,0.00062302937,0.0005014165,0.000076962584,0.00010823912,0.00029444674],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0022202,0.0011929617,0.003602141,0.0004502229,0.0004473472,0.0011086218,0.00070204725,0.0017689992,0.0044470304],"category_scores_gemma":[0.003971966,0.0005068035,0.0022177335,0.00048181246,0.0008318012,0.0007476342,0.00033022102,0.0017830839,0.00037864601],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.984263,0.0018378553,0.0006006275,0.0011539815,0.001399209,0.000021054002,0.00002246577,0.000093916686,0.00056784763,0.00004195266,0.00021940112,0.009778664],"study_design_scores_gemma":[0.97583085,0.021382019,0.00136496,0.00007179428,0.0009188866,0.00001621444,0.000012629866,0.00010278908,0.00010339767,0.000042543645,0.00014776002,0.000006143904],"about_ca_topic_score_codex":0.00074952753,"about_ca_topic_score_gemma":0.0014213476,"teacher_disagreement_score":0.0044470304,"about_ca_system_score_codex":0.0005237854,"about_ca_system_score_gemma":0.0011226705,"threshold_uncertainty_score":0.0148768425},"labels":[],"label_agreement":null},{"id":"W2944370167","doi":"10.1080/14756366.2019.1613987","title":"Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma","year":2019,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institutes of Health Research","funders":"","keywords":"HDAC6; Chemistry; Acetylation; Docking (animal); IC50; Cancer research; Biochemistry; Vorinostat; Pharmacology; Biology; Histone deacetylase; Histone; In vitro; Medicine","score_opus":0.012568709506674772,"score_gpt":0.23220416960862456,"score_spread":0.2196354601019498,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2944370167","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90036035,0.02070786,0.036249384,0.00082452345,0.00030073346,0.0013142088,0.0026561462,0.0006644575,0.036922336],"genre_scores_gemma":[0.96249723,0.008315768,0.01755099,0.00025432336,0.000020108591,0.00022358674,0.0012006884,0.000028405322,0.009908813],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999486,0.0000066144603,0.0000040143223,0.000012600591,0.000010549112,0.00001761852],"domain_scores_gemma":[0.99998176,0.0000011741663,0.000003912406,0.0000013162183,0.0000044076587,0.0000074156674],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107315274,0.0003934698,0.00030790654,0.00025148562,0.00017172474,0.00028798665,0.00038762632,0.00024312992,0.0029038715],"category_scores_gemma":[0.00007351916,0.00016520276,0.00026838764,0.00018796923,0.00013746129,0.00018821888,0.00022864877,0.00041207904,0.0009097223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036902065,0.0002488876,0.00028901384,0.0005988297,0.00003836273,0.00047554355,0.000047127192,0.0023995636,0.971791,0.001702206,0.001058254,0.020982187],"study_design_scores_gemma":[0.0004087135,0.0049685193,0.0015181552,0.000068570735,0.00013755071,0.0009980737,0.00006962719,0.0049185692,0.9427714,0.0005421309,0.043551777,0.00004683039],"about_ca_topic_score_codex":0.0007205818,"about_ca_topic_score_gemma":0.0023404174,"teacher_disagreement_score":0.0029038715,"about_ca_system_score_codex":0.00029711114,"about_ca_system_score_gemma":0.0003321296,"threshold_uncertainty_score":0.009714425},"labels":[],"label_agreement":null},{"id":"W2944560916","doi":"10.1039/c9ob00789j","title":"The Lossen rearrangement from free hydroxamic acids","year":2019,"lang":"en","type":"review","venue":"Organic & Biomolecular Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Chemistry; Hydroxamic acid; Reagent; Combinatorial chemistry; Organic chemistry","score_opus":0.018091861299470928,"score_gpt":0.2977672168468037,"score_spread":0.27967535554733275,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2944560916","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.001970185,0.9899603,0.0010515879,0.00019206788,0.00033114685,0.000011991382,0.000050979193,0.00002724819,0.006404449],"genre_scores_gemma":[0.012362174,0.98192936,0.0005156782,0.00016027481,0.000159116,0.000019624671,0.00007743365,0.000006038576,0.004770272],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998827,0.00001527677,0.000008512523,0.000032075597,0.000038269493,0.000023240395],"domain_scores_gemma":[0.99996376,0.000011470473,0.000008555388,0.000002487178,0.000008599807,0.0000050680783],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022442151,0.00063209835,0.0005710326,0.00073223846,0.00023333644,0.0006639516,0.00049004675,0.00054193905,0.0023279109],"category_scores_gemma":[0.00019717411,0.00025823773,0.00029879622,0.00067688164,0.00034058176,0.0009420679,0.00057191093,0.00087297044,0.0017177231],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019861711,0.00012527223,0.00029739743,0.030336563,0.00014414168,0.0007956052,0.00022100868,0.0013948411,0.09595663,0.038237996,0.025606412,0.80668545],"study_design_scores_gemma":[0.000012165758,0.00013321893,0.00042207987,0.00067374046,0.00004066844,0.0012143207,0.00004466529,0.00019316367,0.02995094,0.0025291957,0.96476215,0.000023735494],"about_ca_topic_score_codex":0.00045477453,"about_ca_topic_score_gemma":0.0006222142,"teacher_disagreement_score":0.0023279109,"about_ca_system_score_codex":0.00040398628,"about_ca_system_score_gemma":0.00039925743,"threshold_uncertainty_score":0.007787645},"labels":[],"label_agreement":null},{"id":"W2946243434","doi":"10.1016/j.ccell.2019.04.004","title":"Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":261,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research; Jewish General Hospital; McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Baylor College of Medicine; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer; Genome Canada; Bear Necessities Pediatric Cancer Foundation; National Institute of Allergy and Infectious Diseases; Cancer Prevention and Research Institute of Texas; Génome Québec; Children's Brain Tumor Foundation","keywords":"Chromatin; Histone; Biology; Epigenomics; Cancer research; Acetylation; Epigenetics; Histone deacetylase; Enhancer; DNA methylation; Genetics; DNA; Gene expression; Gene","score_opus":0.012583629554780953,"score_gpt":0.30061309765772604,"score_spread":0.2880294681029451,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2946243434","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9959608,0.00055064284,0.00096147903,0.00014060197,0.000016466896,0.000011366197,0.00024219863,0.00008743949,0.002029098],"genre_scores_gemma":[0.9986921,0.00019277314,0.00013944683,0.000019191055,0.0000033802487,0.0000030948286,0.000105359526,0.00001332411,0.0008315043],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999008,0.000010639213,0.0000059747035,0.000020830965,0.000025004023,0.000036767102],"domain_scores_gemma":[0.9999088,0.0000073506326,0.000034271994,0.000013405641,0.000008631822,0.000027492219],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000082300096,0.0002088343,0.00017989999,0.0002893087,0.00018585112,0.00036574478,0.00016915088,0.0002177208,0.0025477526],"category_scores_gemma":[0.00014079956,0.00013820452,0.00019410966,0.00024000106,0.0002461263,0.0001506372,0.00026469576,0.00043714853,0.00041583614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006360857,0.000079952224,0.0038329575,0.000032261007,0.00004091879,0.0018162315,0.000028772232,0.0002398728,0.98578435,0.0006196477,0.00034586314,0.0065430375],"study_design_scores_gemma":[0.00007925175,0.0010724926,0.12743868,0.000013866422,0.0001431712,0.023063922,0.00036163532,0.0023037044,0.83648854,0.0014949274,0.0075173513,0.00002248271],"about_ca_topic_score_codex":0.0010674146,"about_ca_topic_score_gemma":0.0012333074,"teacher_disagreement_score":0.0025477526,"about_ca_system_score_codex":0.0003035476,"about_ca_system_score_gemma":0.00023005992,"threshold_uncertainty_score":0.008523047},"labels":[],"label_agreement":null},{"id":"W2947993787","doi":"10.1186/s13395-019-0198-x","title":"Preclinical rationale for entinostat in embryonal rhabdomyosarcoma","year":2019,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institutes of Health; National Cancer Institute; St. Baldrick's Foundation","keywords":"Rhabdomyosarcoma; Medicine; Cancer research; Alveolar rhabdomyosarcoma; Histone deacetylase; Pathology; Sarcoma; Biology; Histone","score_opus":0.01673549571973987,"score_gpt":0.3108282929575436,"score_spread":0.29409279723780374,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2947993787","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92217183,0.0071694055,0.031300977,0.0028525093,0.0011032261,0.007508669,0.0081849275,0.0009014876,0.018806884],"genre_scores_gemma":[0.931356,0.0064391587,0.03131481,0.00067745533,0.00016956276,0.006133419,0.0052866167,0.00011097441,0.0185121],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99955386,0.000106166975,0.0000452986,0.000090409514,0.00013030646,0.000073933516],"domain_scores_gemma":[0.9997217,0.000038357957,0.000047107227,0.000042251337,0.00005864429,0.00009200762],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00091409095,0.0009881567,0.00057496014,0.0005709874,0.00051739824,0.0004691019,0.0010240795,0.00073540537,0.0040803873],"category_scores_gemma":[0.00032599946,0.00034688218,0.00059759326,0.00023459883,0.0005227375,0.00049053045,0.00029563365,0.0022719675,0.0010844397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024321207,0.0038736963,0.00071144017,0.0006468094,0.00009305953,0.00029927152,0.0001181637,0.0016929357,0.9694203,0.0027313686,0.0025815088,0.015399316],"study_design_scores_gemma":[0.0011784012,0.01781134,0.0020562592,0.000078683755,0.00016412495,0.00062411954,0.00007768959,0.0021891051,0.937272,0.00038627032,0.03813729,0.00002461068],"about_ca_topic_score_codex":0.0010873822,"about_ca_topic_score_gemma":0.0041229012,"teacher_disagreement_score":0.0040803873,"about_ca_system_score_codex":0.0010430823,"about_ca_system_score_gemma":0.0011584542,"threshold_uncertainty_score":0.0136502385},"labels":[],"label_agreement":null},{"id":"W2950360708","doi":"10.1016/j.bmcl.2006.05.005","title":"Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: Novel classes of histone deacetylase inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Acetylation; Histone deacetylase; Chemistry; Histone; In vitro; Cell growth; Cancer cell; HDAC11; Histone deacetylase 5; Enzyme; Cancer research; HDAC1; Cell cycle; Biochemistry; Cancer; Apoptosis; Biology; Internal medicine; Gene; Medicine","score_opus":0.009023453301456253,"score_gpt":0.2515959901929952,"score_spread":0.24257253689153896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2950360708","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8393166,0.06932953,0.035584986,0.00096006825,0.0008502035,0.00032484217,0.0006745683,0.0009630866,0.051996067],"genre_scores_gemma":[0.9546074,0.019949466,0.010456601,0.00037491476,0.00019034576,0.00019556582,0.00038408278,0.000039437866,0.0138022],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988294,0.000026228774,0.000008345299,0.000019106477,0.000029349298,0.00003399173],"domain_scores_gemma":[0.99992824,0.000011157349,0.000025401287,0.0000056837066,0.000009809642,0.00001974123],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020863528,0.0003482319,0.0002893655,0.00022444889,0.00016079094,0.000248148,0.000498572,0.00032302726,0.0022525522],"category_scores_gemma":[0.00016175989,0.0001754902,0.0001438316,0.00017979727,0.00022755591,0.00035049723,0.0001804339,0.0004957585,0.00071593584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00056066556,0.00016352578,0.00009512812,0.00029220514,0.000016309226,0.000265013,0.000057902293,0.00079798704,0.967431,0.0038967058,0.00086944894,0.025554014],"study_design_scores_gemma":[0.000303959,0.00288785,0.0019475139,0.00003286541,0.00004023507,0.0010132532,0.000041077026,0.0019102274,0.94647574,0.0004884272,0.044818513,0.000040318],"about_ca_topic_score_codex":0.00038379544,"about_ca_topic_score_gemma":0.0008233633,"teacher_disagreement_score":0.0022525522,"about_ca_system_score_codex":0.00027684594,"about_ca_system_score_gemma":0.00023639284,"threshold_uncertainty_score":0.007535517},"labels":[],"label_agreement":null},{"id":"W2952675939","doi":"10.1002/chin.200416091","title":"(2‐Amino‐phenyl)‐amides of ω‐Substituted Alkanoic Acids as New Histone Deacetylase Inhibitors.","year":2004,"lang":"en","type":"article","venue":"ChemInform","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Association of Nurses in Oncology","funders":"","keywords":"Chemistry; Histone deacetylase; Stereochemistry; Histone; Biochemistry; DNA","score_opus":0.011190052302433535,"score_gpt":0.2784175858537848,"score_spread":0.26722753355135126,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952675939","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8070467,0.07085356,0.025505228,0.0010023346,0.0014828937,0.00035034344,0.0011919376,0.00039869206,0.09216826],"genre_scores_gemma":[0.933254,0.03736554,0.00756007,0.00041456256,0.00012984307,0.00012173108,0.00053429394,0.000043359953,0.020576498],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999486,0.00001228699,0.0000028505092,0.000007954039,0.000009921038,0.000018371733],"domain_scores_gemma":[0.9999671,0.0000070251294,0.000008376118,0.0000026832797,0.0000048789993,0.000010009224],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015854457,0.00037509497,0.0001787617,0.00013830433,0.00009854521,0.00014101708,0.00027848274,0.00025296866,0.004472565],"category_scores_gemma":[0.00011399134,0.00013284481,0.00014220427,0.00014721612,0.00013509669,0.00031106418,0.00018734368,0.00045032223,0.0012501184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000993495,0.00020325265,0.00016409763,0.00064595346,0.000044322864,0.0005164779,0.000111235386,0.0020405275,0.9396817,0.004526102,0.00204443,0.04902835],"study_design_scores_gemma":[0.00041581213,0.004302535,0.0019463638,0.00013465666,0.0000677664,0.00076910283,0.00007845304,0.002289245,0.91082686,0.001021551,0.078104146,0.000043453878],"about_ca_topic_score_codex":0.00032085727,"about_ca_topic_score_gemma":0.00080186623,"teacher_disagreement_score":0.004472565,"about_ca_system_score_codex":0.00016311873,"about_ca_system_score_gemma":0.00013676051,"threshold_uncertainty_score":0.014962196},"labels":[],"label_agreement":null},{"id":"W2953145956","doi":"10.1186/s13046-019-1242-8","title":"Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation","year":2019,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; University of Ottawa; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Cancer Research Society","keywords":"Acetylation; Lysine; Drug; Cancer research; Chemistry; Apoptosis; Heart failure; Leukemia; Pharmacology; Internal medicine; Medicine; Biochemistry; Gene; Amino acid","score_opus":0.055315700692271506,"score_gpt":0.47667325323121434,"score_spread":0.42135755253894286,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2953145956","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9920873,0.0032255428,0.002124637,0.00012182763,0.000034938304,0.000037737558,0.00058885117,0.000096949,0.0016822349],"genre_scores_gemma":[0.99487597,0.0014118671,0.0012219566,0.00008869477,0.000014691319,0.000026518699,0.00077518774,0.000010682914,0.0015743609],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995124,0.000006492434,0.000004268437,0.000013106825,0.0000147111805,0.000010238648],"domain_scores_gemma":[0.999946,0.0000073546503,0.000022166569,0.0000060532966,0.000007990405,0.000010373905],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000079443205,0.00024801365,0.00016264814,0.00014058559,0.00008534537,0.00017363054,0.00012304385,0.00014309878,0.0012766321],"category_scores_gemma":[0.00006981468,0.000054771837,0.00012922837,0.00013861564,0.00012914067,0.00010394963,0.00009706995,0.00034556043,0.00024991782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020365471,0.000032501328,0.00035227748,0.000046117242,0.000009910332,0.00003708633,0.000003846849,0.00010203727,0.99555236,0.000050603434,0.00006521883,0.003544352],"study_design_scores_gemma":[0.00006103327,0.0013081329,0.010522237,0.000007146888,0.000040125047,0.0004662355,0.000012540095,0.0008082692,0.9827776,0.00006539944,0.0039268197,0.00000446135],"about_ca_topic_score_codex":0.00014217879,"about_ca_topic_score_gemma":0.00028717672,"teacher_disagreement_score":0.0012766321,"about_ca_system_score_codex":0.00019304449,"about_ca_system_score_gemma":0.000109811626,"threshold_uncertainty_score":0.004270792},"labels":[],"label_agreement":null},{"id":"W2953534116","doi":"10.7939/r30k26t4n","title":"Biology and Prognostic Value of N-Myristoyltransferase 1 (NMT1) and NMT2 in Acute Myeloid Leukemia (AML)","year":2017,"lang":"en","type":"article","venue":"University of Alberta Library","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Myeloid leukemia; Value (mathematics); Cancer research; Leukemia; Biology; Medicine; Genetics; Computer science","score_opus":0.005549710098886365,"score_gpt":0.22009914975586595,"score_spread":0.2145494396569796,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2953534116","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99812466,0.00107092,0.00019265608,0.00006108119,0.000006176652,0.00000757554,0.0001951216,0.000008522057,0.00033331662],"genre_scores_gemma":[0.9985837,0.000278607,0.00036679106,0.000016800743,0.00001874471,0.000009413647,0.00046092135,0.0000025702511,0.00026260188],"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979097,0.000046039324,0.000020885205,0.00005686632,0.000037723126,0.000047476948],"domain_scores_gemma":[0.9996345,0.00007596583,0.000118718905,0.00003412566,0.000038627975,0.00009806418],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010197797,0.00025845107,0.0002316544,0.0010332435,0.00029352616,0.0005349944,0.00034303826,0.00044995538,0.0008788238],"category_scores_gemma":[0.00086438906,0.00020120127,0.00016973607,0.00070653856,0.00033376017,0.00040292979,0.00042896817,0.00038103067,0.0002983988],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011339191,0.000037135196,0.9811519,0.000020034237,0.0000223581,0.00022415904,0.00005344807,0.00018960627,0.010843832,0.000043813834,0.00017623077,0.0061035166],"study_design_scores_gemma":[0.000016690576,0.0002125211,0.9946503,0.000006338666,0.000036331836,0.00084578,0.000082320315,0.0009965021,0.0022610417,0.00008269691,0.0008019908,0.0000074823265],"about_ca_topic_score_codex":0.0009509351,"about_ca_topic_score_gemma":0.001580733,"teacher_disagreement_score":0.0010332435,"about_ca_system_score_codex":0.00049953174,"about_ca_system_score_gemma":0.00023464356,"threshold_uncertainty_score":0.0053931475},"labels":[],"label_agreement":null},{"id":"W2970183321","doi":"10.1016/j.placenta.2019.06.257","title":"Histone deacetylases 1 and 2 control cytotrophoblast differentiation and syncytiotrophoblast development","year":2019,"lang":"en","type":"article","venue":"Placenta","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; McGill University; Western University","funders":"","keywords":"Syncytiotrophoblast; Cytotrophoblast; Cell biology; H3K4me3; Histone; Epigenome; Chemistry; Biology; Genetics; DNA methylation; Pregnancy; Placenta; Biochemistry; Gene; Fetus; Gene expression","score_opus":0.004223020573555312,"score_gpt":0.23008520278688208,"score_spread":0.22586218221332677,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2970183321","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87133867,0.06970862,0.027016046,0.001990713,0.00081502163,0.0002206433,0.0028764869,0.000953134,0.025080714],"genre_scores_gemma":[0.96407115,0.010225988,0.0060825814,0.0002970828,0.000106505315,0.00007811403,0.0013806584,0.000111511814,0.017646383],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99975127,0.000037401813,0.000018364357,0.000072379844,0.00005265897,0.00006791693],"domain_scores_gemma":[0.9998016,0.000031679327,0.00006417509,0.00002518192,0.000024599074,0.000052887044],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039438927,0.0005268827,0.00030815674,0.0006386644,0.0003839098,0.0009504392,0.0005152318,0.00038740557,0.002425597],"category_scores_gemma":[0.00042027305,0.0005477575,0.00036053796,0.00034737,0.00048424726,0.0005141194,0.00047238028,0.0008460403,0.00067751214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007065225,0.00002150905,0.0019352072,0.000068880574,0.000023483959,0.00015149919,0.00008629184,0.00013658659,0.9874256,0.0017780787,0.00033497898,0.0073313303],"study_design_scores_gemma":[0.00011201218,0.00029553808,0.035792228,0.000028195396,0.00005901271,0.00051823154,0.0002406482,0.0011727156,0.9371778,0.001019441,0.023560805,0.000023308225],"about_ca_topic_score_codex":0.002200353,"about_ca_topic_score_gemma":0.0054328223,"teacher_disagreement_score":0.002425597,"about_ca_system_score_codex":0.0012617626,"about_ca_system_score_gemma":0.00061294384,"threshold_uncertainty_score":0.009154737},"labels":[],"label_agreement":null},{"id":"W2972973297","doi":"10.1016/j.isci.2019.09.015","title":"Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; McGill University; Occupational Cancer Research Centre","funders":"China Scholarship Council; Canadian Institutes of Health Research; Cancer Research Society; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Neurosphere; Neurogenesis; Histone deacetylase; Biology; Progenitor cell; Cell biology; Neural stem cell; Cerebrum; Nestin; HDAC1; Epigenetics; Neuroscience; Histone; Stem cell; Embryonic stem cell; Adult stem cell; Genetics; Central nervous system; Gene","score_opus":0.00904623677166688,"score_gpt":0.2565254359206256,"score_spread":0.24747919914895872,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2972973297","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98224455,0.0036991946,0.009512267,0.00012321715,0.000033536737,0.000023335622,0.000582368,0.00019438518,0.003587089],"genre_scores_gemma":[0.9921727,0.0021993048,0.0028063369,0.00004472012,0.000008359413,0.000019909605,0.00054233667,0.000037877977,0.0021684852],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992895,0.0000070935084,0.0000046509895,0.000017315975,0.000022721035,0.000019220706],"domain_scores_gemma":[0.9999368,0.000006631613,0.00002265574,0.00000637303,0.0000069160974,0.000020648244],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000098317134,0.0003300067,0.00017038973,0.00022362245,0.00013038282,0.00028220325,0.0002167058,0.00012775358,0.00087917136],"category_scores_gemma":[0.00007852074,0.00012700561,0.00018705275,0.00010715505,0.0003062393,0.00012690647,0.00016350928,0.00032206075,0.00028715178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008961381,0.0000059772888,0.0008924206,0.000022981194,0.0000062264317,0.00009621248,0.000014609157,0.000048848637,0.99605066,0.0002930664,0.00003542394,0.0024440738],"study_design_scores_gemma":[0.0000080230575,0.00007930467,0.012392336,0.0000062543486,0.000024777179,0.00030449274,0.000033267333,0.00044662002,0.98428196,0.00016860665,0.0022508937,0.0000036203778],"about_ca_topic_score_codex":0.0015016169,"about_ca_topic_score_gemma":0.00380553,"teacher_disagreement_score":0.0015016169,"about_ca_system_score_codex":0.00040925018,"about_ca_system_score_gemma":0.00037079077,"threshold_uncertainty_score":0.0029857755},"labels":[],"label_agreement":null},{"id":"W2976363693","doi":"10.1101/268557","title":"Identification and Structure-Activity Relationship of HDAC6 Zinc-finger Ubiquitin Binding Domain Inhibitors","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Ubiquitin; Chemistry; Proteasome; Zinc finger; Cell biology; Virtual screening; Binding site; Ligand (biochemistry); Binding domain; Computational biology; Biochemistry; Drug discovery; Biophysics; Biology; Receptor","score_opus":0.014489075695442236,"score_gpt":0.2562303015421973,"score_spread":0.24174122584675506,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2976363693","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96935993,0.012623378,0.0057024946,0.00020829486,0.000046609806,0.00023938768,0.0036288886,0.00020037923,0.00799067],"genre_scores_gemma":[0.9807124,0.0039682407,0.0060898657,0.00009947806,0.000021359068,0.00006721766,0.0046137725,0.000027353337,0.0044002277],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984777,0.000022728836,0.000012203215,0.000029052415,0.000053102012,0.000035129866],"domain_scores_gemma":[0.9998934,0.000019200566,0.0000201749,0.000010023626,0.00003028854,0.000026902677],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027589526,0.00048351943,0.00050305546,0.000649485,0.00017213015,0.000491303,0.000390656,0.00028183783,0.0029369981],"category_scores_gemma":[0.00025712652,0.00017195691,0.00043900686,0.0005221546,0.000121308934,0.00024175383,0.00019915975,0.0004722409,0.0007701651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010719055,0.0007640735,0.0032126969,0.00022545403,0.00014214123,0.00015243275,0.000025013564,0.006011867,0.95299166,0.0006337117,0.00089088985,0.033878215],"study_design_scores_gemma":[0.00019209897,0.0029671348,0.005309354,0.000012241444,0.00013037917,0.00049859384,0.000018611654,0.00529413,0.97736907,0.0001578315,0.008032973,0.000017515187],"about_ca_topic_score_codex":0.0010508482,"about_ca_topic_score_gemma":0.0013509246,"teacher_disagreement_score":0.0029369981,"about_ca_system_score_codex":0.00049501925,"about_ca_system_score_gemma":0.00028139295,"threshold_uncertainty_score":0.00982523},"labels":[],"label_agreement":null},{"id":"W2979564813","doi":"10.1182/blood.v128.22.1533.1533","title":"Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling By Suppression of Mir-146a in Acute Myeloid Leukemia","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Syk; Myeloid leukemia; Hox gene; Biology; Cancer research; Leukemia; Cell biology; Downregulation and upregulation; Signal transduction; Transcriptome; Transcription factor; Context (archaeology); Tyrosine kinase; Gene expression; Immunology; Gene; Genetics","score_opus":0.007866881087451918,"score_gpt":0.25561431554759084,"score_spread":0.24774743446013892,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2979564813","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99646324,0.00094305846,0.0014596015,0.000046077585,0.000021395375,0.000016957174,0.00028358123,0.000063383275,0.0007027051],"genre_scores_gemma":[0.99682117,0.00031527516,0.0011068023,0.000029161203,0.0000055588343,0.000025714873,0.00037960507,0.000014827927,0.0013017337],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998191,0.00003164129,0.000022572678,0.000039138533,0.00005584416,0.000031699827],"domain_scores_gemma":[0.9999211,0.000014933992,0.000026122858,0.000011140246,0.000005726332,0.000020970276],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012857876,0.00027763945,0.000268457,0.00019949769,0.00011250627,0.0002659966,0.00013827888,0.00015402197,0.0009812715],"category_scores_gemma":[0.00008205302,0.00015757143,0.00023728954,0.00012611474,0.00020531872,0.000108366956,0.0002451541,0.00047005469,0.0004397966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000059312115,0.00001339072,0.00010698012,0.000010302233,0.00000223171,0.000015824327,0.0000042286647,0.000018629064,0.9994591,0.000028047134,0.000010276386,0.00027159406],"study_design_scores_gemma":[0.000011982273,0.00019114457,0.006341162,0.0000023368855,0.000009922518,0.00015394812,0.000016421835,0.0012313424,0.990853,0.000028716879,0.0011577021,0.0000023171212],"about_ca_topic_score_codex":0.00015523453,"about_ca_topic_score_gemma":0.0002444511,"teacher_disagreement_score":0.0009812715,"about_ca_system_score_codex":0.00015242539,"about_ca_system_score_gemma":0.000095042415,"threshold_uncertainty_score":0.0032826662},"labels":[],"label_agreement":null},{"id":"W2980088049","doi":"10.1182/blood.v110.11.908.908","title":"A Phase I Trial of Two Sequence-Specific Schedules of Decitabine and Vorinostat in Patients with Acute Myeloid Leukemia (AML).","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hamilton Health Sciences; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Decitabine; Medicine; Tolerability; Mucositis; Vorinostat; Regimen; Internal medicine; Hypomethylating agent; Leukopenia; Neutropenia; Phases of clinical research; Oncology; Gastroenterology; Adverse effect; Pharmacology; Surgery; Toxicity; Histone deacetylase; Biology","score_opus":0.013084975064968155,"score_gpt":0.2923354127578263,"score_spread":0.2792504376928582,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2980088049","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9927124,0.0019285575,0.00047089023,0.0005412705,0.00020088902,0.0020273954,0.000499303,0.00007266786,0.0015467515],"genre_scores_gemma":[0.9889686,0.001378349,0.0019040881,0.0008616994,0.00027557596,0.003066002,0.0014924158,0.000019507643,0.0020337969],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99965525,0.0001427733,0.000021140257,0.00007164736,0.00002948067,0.00007979908],"domain_scores_gemma":[0.9992754,0.00011670127,0.00015020107,0.000057311572,0.000025328407,0.0003750802],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011294859,0.0017149909,0.0016770405,0.00045933676,0.0004156364,0.0006057385,0.0009474114,0.0012907604,0.00371022],"category_scores_gemma":[0.00082810916,0.0006233651,0.00091373734,0.00036302465,0.00095588353,0.0007509531,0.0004677073,0.0034363188,0.000727989],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.77957946,0.06592109,0.0038693561,0.0007593067,0.00085616566,0.00027846172,0.0002729461,0.0027243553,0.038692024,0.0004923277,0.0035951408,0.10295936],"study_design_scores_gemma":[0.69693327,0.2946035,0.003444436,0.00002271323,0.00018113897,0.00019408925,0.00003236898,0.0006833838,0.0022375998,0.00015351045,0.0014973138,0.000016633909],"about_ca_topic_score_codex":0.0005618246,"about_ca_topic_score_gemma":0.0013237635,"teacher_disagreement_score":0.00371022,"about_ca_system_score_codex":0.0007945736,"about_ca_system_score_gemma":0.001297164,"threshold_uncertainty_score":0.012411892},"labels":[],"label_agreement":null},{"id":"W2982674222","doi":"10.15252/embr.201948375","title":"Class I HDAC inhibitors enhance YB‐1 acetylation and oxidative stress to block sarcoma metastasis","year":2019,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Provincial Health Services Authority; University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Michael Smith Health Research BC; Government of Canada","keywords":"Metastasis; Library science; Medicine; Cancer; Oncology; Cancer research; Internal medicine; Computer science","score_opus":0.007467732761408658,"score_gpt":0.27819571074014754,"score_spread":0.2707279779787389,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2982674222","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9811024,0.006193443,0.003890109,0.00030558315,0.00012025851,0.00009764248,0.0006654373,0.0004158626,0.007209311],"genre_scores_gemma":[0.9868571,0.0036083907,0.0021268472,0.00008825971,0.000027798333,0.00003713508,0.0004919416,0.000040861174,0.006721676],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999515,0.000004838652,0.0000036096924,0.000009331879,0.000014474782,0.000016368964],"domain_scores_gemma":[0.99996746,0.000003449023,0.000010396304,0.0000033094427,0.0000043163186,0.000011102771],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000873641,0.0004006004,0.00023245065,0.00022946732,0.00008239425,0.0001601228,0.00020146524,0.00012327614,0.0024107252],"category_scores_gemma":[0.000054996053,0.00010587185,0.00018485171,0.00013370211,0.00016791846,0.00013959853,0.000104562925,0.000404052,0.00039222252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003988585,0.000104652514,0.00020327161,0.000072694704,0.0000150847945,0.000026248452,0.0000056092554,0.00017210864,0.9917672,0.0002814285,0.0002723023,0.0066804416],"study_design_scores_gemma":[0.000099725556,0.0008490701,0.0022431114,0.0000053444,0.000028036031,0.00010261787,0.000010221082,0.00050339237,0.98980266,0.00005060409,0.0063013346,0.00000388044],"about_ca_topic_score_codex":0.00090162025,"about_ca_topic_score_gemma":0.002882754,"teacher_disagreement_score":0.0024107252,"about_ca_system_score_codex":0.00035325182,"about_ca_system_score_gemma":0.0002560709,"threshold_uncertainty_score":0.008064747},"labels":[],"label_agreement":null},{"id":"W2985480179","doi":"10.1182/blood-2019-129845","title":"Landmark Response and Survival Analyses from 206 AML Patients Treated with Guadecitabine in a Phase 2 Study Demonstrate the Importance of Adequate Treatment Duration to Maximize Response and Survival Benefit. Survival Benefit Not Restricted to Patients with Objective Response","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Survival analysis; Cell survival; Overall survival; Medicine; Internal medicine; Oncology; Biology; Apoptosis; Genetics","score_opus":0.01624265700697788,"score_gpt":0.290430284858995,"score_spread":0.27418762785201717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2985480179","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9982613,0.00015407072,0.0005857177,0.000031804142,0.0000065970107,0.000119393284,0.0004826053,0.000025093013,0.00033353237],"genre_scores_gemma":[0.99481297,0.00007796179,0.001795041,0.00008066756,0.000025883865,0.00027581872,0.002333994,0.000013651394,0.0005840848],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9995215,0.00022884813,0.00004100799,0.000069335445,0.000086902706,0.000052423708],"domain_scores_gemma":[0.9986896,0.00044590904,0.0003479478,0.00020260806,0.000083075196,0.00023083245],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001356356,0.0003531934,0.0007240328,0.00030168644,0.00024353545,0.00029437698,0.00021614965,0.000393476,0.0014624713],"category_scores_gemma":[0.001448216,0.0001241511,0.00074643607,0.00024626573,0.00026919876,0.00030485616,0.00031120007,0.0008163977,0.00023428211],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.3457254,0.01450234,0.3400596,0.00049371284,0.0013127611,0.0011068587,0.0006929383,0.014559672,0.11647985,0.00039620197,0.0036398408,0.16103083],"study_design_scores_gemma":[0.020155668,0.25936,0.6620869,0.000029897168,0.0007702775,0.0023904964,0.00015929539,0.0083107315,0.039328754,0.00045968755,0.006846582,0.000101695405],"about_ca_topic_score_codex":0.00029010663,"about_ca_topic_score_gemma":0.0005607717,"teacher_disagreement_score":0.0014624713,"about_ca_system_score_codex":0.00038921428,"about_ca_system_score_gemma":0.00032479395,"threshold_uncertainty_score":0.00717324},"labels":[],"label_agreement":null},{"id":"W2988924036","doi":"10.1182/blood-2019-122784","title":"The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Respiratory chain; Gene knockdown; Biology; Haematopoiesis; Stem cell; Myeloid leukemia; Mitochondrial respiratory chain; Mitochondrion; Leukemia; Myeloid; Small hairpin RNA; Molecular biology; Cancer research; Cell culture; Cell biology; Immunology; Genetics","score_opus":0.01626558467352507,"score_gpt":0.262568239818473,"score_spread":0.24630265514494792,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2988924036","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99141216,0.001003696,0.0051068356,0.00008910823,0.000009737613,0.00002070275,0.001410345,0.000117619515,0.0008297457],"genre_scores_gemma":[0.99047273,0.0007081873,0.004998614,0.00003145883,0.0000050026033,0.000018876584,0.0021815319,0.000024957475,0.0015585739],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998647,0.000009709145,0.000016245995,0.000040817664,0.0000497402,0.00001880256],"domain_scores_gemma":[0.9998621,0.000021545657,0.00006467776,0.000011300864,0.00001677264,0.000023553293],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011192203,0.00020663496,0.0002450403,0.00020683561,0.00018269589,0.00029107378,0.00010666549,0.00014445781,0.00066248747],"category_scores_gemma":[0.00017721021,0.00009558567,0.0001856972,0.00017418405,0.00017272137,0.00017042905,0.00019151492,0.00020495101,0.0003276983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00002858794,0.0000028040065,0.0006195593,0.00001487599,0.0000020215268,0.00003864165,0.000006754811,0.000031186184,0.99844176,0.000027059496,0.00002181923,0.00076501607],"study_design_scores_gemma":[0.0000060937305,0.000057244622,0.02227488,0.0000044997446,0.000012402151,0.00050581957,0.000027774586,0.0010683011,0.9737092,0.000043975186,0.002286107,0.0000036870501],"about_ca_topic_score_codex":0.0010765217,"about_ca_topic_score_gemma":0.002275119,"teacher_disagreement_score":0.0010765217,"about_ca_system_score_codex":0.00045095113,"about_ca_system_score_gemma":0.00019934727,"threshold_uncertainty_score":0.0032719374},"labels":[],"label_agreement":null},{"id":"W2990892635","doi":"10.1186/s12985-019-1249-y","title":"Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication","year":2019,"lang":"en","type":"article","venue":"Virology Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Montréal","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Integrase; Biology; Virology; Viral replication; Molecular biology; Immunoprecipitation; Infectivity; Integrase inhibitor; Cell culture; Virus; Human immunodeficiency virus (HIV); Genetics; Viral load","score_opus":0.005260312223834165,"score_gpt":0.26813315014053407,"score_spread":0.2628728379166999,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2990892635","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9844195,0.008735381,0.0028818513,0.00025271456,0.00007220156,0.000027902333,0.00075948506,0.00011175206,0.0027392658],"genre_scores_gemma":[0.9922805,0.0025061239,0.0016755705,0.00010380746,0.00002797454,0.000015339707,0.0010540218,0.000025057403,0.0023115827],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998684,0.0000102113545,0.000007747836,0.00004247199,0.0000409986,0.000030113992],"domain_scores_gemma":[0.9999356,0.000009034564,0.000019435482,0.0000057226703,0.000009186128,0.000021000422],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399057,0.00033144795,0.000248174,0.00019134316,0.00018498518,0.00045655327,0.0002554369,0.00025794713,0.0017133858],"category_scores_gemma":[0.00014282695,0.00014212064,0.000344398,0.00017552653,0.00020587309,0.00020100204,0.00020347354,0.0004259859,0.00058540434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016278468,0.000028282395,0.0021924626,0.00008838666,0.000022715121,0.0000564475,0.000017187924,0.00006483488,0.99418855,0.00009572648,0.00015550632,0.0029270244],"study_design_scores_gemma":[0.000044297194,0.00026889535,0.051809605,0.00002321712,0.000085064115,0.0005114616,0.00006644599,0.003012857,0.93723893,0.00014593356,0.006778767,0.000014579412],"about_ca_topic_score_codex":0.0006818163,"about_ca_topic_score_gemma":0.0012060651,"teacher_disagreement_score":0.0017133858,"about_ca_system_score_codex":0.000619642,"about_ca_system_score_gemma":0.0001580302,"threshold_uncertainty_score":0.0057318807},"labels":[],"label_agreement":null},{"id":"W2995409991","doi":"10.3390/cancers11122036","title":"Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Blood Cancer UK; Bloodwise; Université de Genève; Queen's University; Queen's University Belfast; Newcastle University; University of Toronto; Canadian Cancer Society","keywords":"Cancer research; Leukemia; Transcriptome; Biology; Fanconi anemia; Drug repositioning; Myeloid leukemia; Haematopoiesis; Gene; Cell cycle; Computational biology; Stem cell; Gene expression; Genetics; DNA repair; Pharmacology; Drug","score_opus":0.008771651411516054,"score_gpt":0.23501418810329142,"score_spread":0.22624253669177535,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2995409991","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96315175,0.01257448,0.012090926,0.00089346786,0.00006645496,0.00022230227,0.0025100848,0.00040754236,0.008082925],"genre_scores_gemma":[0.985794,0.005353398,0.0026068392,0.00012957348,0.0000100214165,0.000081923696,0.0016879047,0.000011149577,0.0043252595],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99993074,0.000008029469,0.0000039487986,0.000016018841,0.000023894834,0.000017415141],"domain_scores_gemma":[0.9999665,0.0000034329141,0.000013709242,0.0000036783738,0.0000042718825,0.000008337404],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011214798,0.00040131685,0.00028394858,0.00036812242,0.00018914827,0.00043899828,0.00023917598,0.00021664092,0.0020449122],"category_scores_gemma":[0.0000564968,0.00011317867,0.00033225882,0.00028316595,0.00017443801,0.00016945066,0.00023159519,0.00048688083,0.0003716229],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007539814,0.0002332648,0.0031381922,0.00021300768,0.000049626215,0.0003719601,0.000022123255,0.0017070184,0.9769621,0.0025389993,0.00078665523,0.013223092],"study_design_scores_gemma":[0.0002015241,0.0020524734,0.04223591,0.000042489744,0.000216598,0.0021948437,0.00011654116,0.016062064,0.90116006,0.0027570114,0.03292951,0.00003096178],"about_ca_topic_score_codex":0.00066878425,"about_ca_topic_score_gemma":0.0014242667,"teacher_disagreement_score":0.0020449122,"about_ca_system_score_codex":0.00065962126,"about_ca_system_score_gemma":0.00036250387,"threshold_uncertainty_score":0.0068409443},"labels":[],"label_agreement":null},{"id":"W2996612587","doi":"10.1021/acsmedchemlett.9b00471","title":"Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Mitacs; Canada Research Chairs; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Myeloid leukemia; Bioavailability; Pharmacology; Leukemia; Benzamide; Histone deacetylase inhibitor; Cytotoxicity; Cancer research; Chemistry; Medicine; Histone deacetylase; Immunology; Biochemistry; In vitro; Gene; Histone; Stereochemistry","score_opus":0.008421389672362074,"score_gpt":0.2612491898393479,"score_spread":0.25282780016698586,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2996612587","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9913674,0.0038595062,0.0012461164,0.00011555711,0.000019933344,0.00006637944,0.00043516158,0.00009697931,0.002792911],"genre_scores_gemma":[0.99450594,0.0020692567,0.0009971635,0.00006348989,0.000015492888,0.000024595232,0.0007103621,0.000012210245,0.0016014043],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994636,0.000010274339,0.0000045029237,0.000009925312,0.000011343411,0.000017568147],"domain_scores_gemma":[0.9999653,0.000006118884,0.000008744333,0.0000044265635,0.00000472512,0.0000106238185],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013047311,0.00023007547,0.0002835674,0.00016952322,0.000106308675,0.00017440658,0.00015875485,0.00012741634,0.0010691284],"category_scores_gemma":[0.00011196879,0.0000918709,0.00014352499,0.0001463813,0.00011378205,0.00010120422,0.00008171475,0.00034763865,0.0002592156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010757449,0.00034231303,0.00047420085,0.00008373855,0.00001916936,0.000075365024,0.000018800602,0.00040230973,0.97813326,0.00014370757,0.00034713632,0.018884312],"study_design_scores_gemma":[0.0005632848,0.014443914,0.014149881,0.000016412669,0.00010706927,0.00063761394,0.000026140746,0.002195995,0.9600248,0.00008344005,0.0077336635,0.00001775806],"about_ca_topic_score_codex":0.0010330131,"about_ca_topic_score_gemma":0.0017400515,"teacher_disagreement_score":0.0010691284,"about_ca_system_score_codex":0.00022401019,"about_ca_system_score_gemma":0.0001732814,"threshold_uncertainty_score":0.0035765767},"labels":[],"label_agreement":null},{"id":"W3000328267","doi":"10.1038/s41598-019-57294-x","title":"HDAC10 deletion promotes Foxp3+ T-regulatory cell function","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services; National Institutes of Health; McGill University; American Society of Nephrology; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health","keywords":"HDAC10; FOXP3; Cancer research; Histone deacetylase; Histone; Biology; Immune system; Immunology; Genetics; Gene","score_opus":0.011939434624060153,"score_gpt":0.23610528484133556,"score_spread":0.2241658502172754,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3000328267","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99269825,0.0011115432,0.0023316105,0.00019018032,0.00014137774,0.000047511312,0.0006458134,0.0003632773,0.0024704107],"genre_scores_gemma":[0.9912559,0.0005156356,0.0015522314,0.00012508284,0.000030960702,0.000045459663,0.0005939896,0.00006714557,0.005813537],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997527,0.00003378616,0.00002329584,0.000042313375,0.000056896148,0.000091069574],"domain_scores_gemma":[0.99962866,0.000066259316,0.00007701676,0.00003529849,0.000024904797,0.00016792177],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022517362,0.0004527783,0.00027923062,0.00027207367,0.00014365082,0.0002696737,0.0002942844,0.00033611638,0.0042319573],"category_scores_gemma":[0.00012771289,0.00019577976,0.0002396928,0.00011915986,0.00034772052,0.00017175797,0.00016102813,0.0010100049,0.00097085524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016714176,0.00006935154,0.00015176124,0.000025577345,0.0000029874568,0.000034660046,0.000004927175,0.00003462513,0.99866235,0.000038266808,0.00007159654,0.0007367547],"study_design_scores_gemma":[0.00006694542,0.0011039923,0.0036350314,0.000009013471,0.000014851845,0.00017339215,0.000030644085,0.0006638391,0.99198467,0.000042990778,0.0022701737,0.000004421681],"about_ca_topic_score_codex":0.0010140352,"about_ca_topic_score_gemma":0.0019208757,"teacher_disagreement_score":0.0042319573,"about_ca_system_score_codex":0.00031631565,"about_ca_system_score_gemma":0.00024050089,"threshold_uncertainty_score":0.014157295},"labels":[],"label_agreement":null},{"id":"W3003176324","doi":"10.1186/s13148-019-0800-4","title":"Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells","year":2020,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Advanced Centre for Treatment, Research and Education in Cancer; Bhabha Atomic Research Centre; University Grants Commission; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Acetylation; Phenotype; Breast cancer; Epigenetics; Histone; Human genetics; Cancer research; Medicine; Biology; Cancer; Internal medicine; Genetics; Gene","score_opus":0.041572977840447015,"score_gpt":0.36525447356383506,"score_spread":0.32368149572338806,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3003176324","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9972596,0.000770672,0.00084336783,0.000033489297,0.000014013719,0.00001642049,0.00038735825,0.000037338643,0.00063769566],"genre_scores_gemma":[0.9974253,0.000334796,0.0005080151,0.00002514851,0.0000051718966,0.000021315414,0.000590628,0.000007484556,0.0010822947],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999063,0.000013916938,0.000011604108,0.000020484296,0.000023776003,0.00002395686],"domain_scores_gemma":[0.99993753,0.000010942931,0.000015858617,0.000011948518,0.000010161079,0.00001358238],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000872116,0.00019570511,0.00026473185,0.00020427053,0.00010364339,0.00017556387,0.00009982907,0.00015724394,0.0021518918],"category_scores_gemma":[0.0000817903,0.00012696552,0.00020590039,0.00015958399,0.00011735385,0.000050549374,0.00011400481,0.00027675464,0.0003946646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008421926,0.000015673673,0.0011817685,0.000017913027,0.000008610615,0.00006683943,0.000013891495,0.00002210226,0.9979431,0.000015553584,0.000030283187,0.0006000643],"study_design_scores_gemma":[0.00001096766,0.0006310674,0.050116703,0.0000040684854,0.000041778945,0.0012526467,0.000071440416,0.00046067662,0.94557315,0.000029935249,0.0018024638,0.000005148971],"about_ca_topic_score_codex":0.0006475488,"about_ca_topic_score_gemma":0.0006746938,"teacher_disagreement_score":0.0021518918,"about_ca_system_score_codex":0.00013912705,"about_ca_system_score_gemma":0.00009007779,"threshold_uncertainty_score":0.00719887},"labels":[],"label_agreement":null},{"id":"W3005547754","doi":"10.1007/s12031-020-01505-y","title":"HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Neuroscience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Terry Fox Research Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Ontario Institute for Cancer Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; American Brain Tumor Association; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Genome Canada; Genome British Columbia; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Brain Tumour Foundation of Canada","keywords":"MAPK/ERK pathway; Homeobox protein NANOG; BMI1; Cancer stem cell; Biology; Cancer research; Histone deacetylase; Neurosphere; SOX2; Stem cell; Neural stem cell; RHOA; Embryonic stem cell; Cell biology; Signal transduction; Histone; Biochemistry; Adult stem cell; Induced pluripotent stem cell","score_opus":0.014924407480932288,"score_gpt":0.2821991147860952,"score_spread":0.26727470730516295,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3005547754","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9958489,0.0014054396,0.000750323,0.000112233975,0.000029723278,0.000019215622,0.0002995547,0.000083222934,0.0014513612],"genre_scores_gemma":[0.9967026,0.0007774665,0.0004626218,0.000022861692,0.0000067455467,0.000019559735,0.00034953447,0.0000149588295,0.0016436552],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998902,0.000012081137,0.000010815704,0.000011923126,0.000034353165,0.000040643943],"domain_scores_gemma":[0.9999045,0.00001793123,0.000018676672,0.000009689478,0.000008234921,0.00004090525],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014593283,0.00030642533,0.00033267975,0.00038260323,0.00022123533,0.00032526124,0.0002888652,0.00017172736,0.0013779314],"category_scores_gemma":[0.00013786796,0.00017422908,0.0002870278,0.00021160151,0.0002017228,0.00020568237,0.00021365275,0.0006549862,0.00024511578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005357467,0.00011938545,0.0007138921,0.000037212227,0.00001965931,0.000079964244,0.000023104209,0.00019853667,0.99433833,0.00023461324,0.00015153171,0.0035479437],"study_design_scores_gemma":[0.00005073041,0.0006794305,0.011183983,0.0000041131993,0.000045361397,0.00019398997,0.00006152269,0.0010524866,0.9838664,0.000089108544,0.0027685983,0.0000041145963],"about_ca_topic_score_codex":0.0021877103,"about_ca_topic_score_gemma":0.006229408,"teacher_disagreement_score":0.0021877103,"about_ca_system_score_codex":0.00039763612,"about_ca_system_score_gemma":0.00038626164,"threshold_uncertainty_score":0.0046096444},"labels":[],"label_agreement":null},{"id":"W3005827157","doi":"10.1158/1538-7445.sabcs19-p3-06-10","title":"Abstract P3-06-10: Temozolomide &amp; vorinostat as a targeted therapy strategy for triple negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary; Alberta Health Services","funders":"","keywords":"Temozolomide; Triple-negative breast cancer; Vorinostat; Cancer research; PARP inhibitor; Breast cancer; Medicine; Cisplatin; Combination therapy; Decitabine; Oncology; Cancer; Internal medicine; Chemotherapy; DNA methylation; Histone deacetylase; Biology; Glioma; Histone; Poly ADP ribose polymerase; DNA","score_opus":0.10171294337917446,"score_gpt":0.42342487257336875,"score_spread":0.3217119291941943,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3005827157","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5428282,0.2899968,0.009551411,0.011577258,0.0041763033,0.0015255143,0.0079623945,0.0019327749,0.13044924],"genre_scores_gemma":[0.83920914,0.086752996,0.007815544,0.003097533,0.0007684328,0.0004428324,0.0065518483,0.00013016503,0.055231556],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996245,0.000005471182,0.0000024879907,0.00000658676,0.000012493408,0.000010509715],"domain_scores_gemma":[0.9999677,0.0000022107374,0.0000049658224,0.0000018920246,0.0000069646426,0.000016246862],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012232135,0.00030278284,0.00028920636,0.00031509006,0.00015989729,0.00038449306,0.0003011548,0.0003202891,0.01099336],"category_scores_gemma":[0.00006853943,0.00006619371,0.0002749982,0.00024780302,0.000121667006,0.00021966457,0.00022868649,0.0008755432,0.0031854163],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0045696306,0.0018716019,0.0010771162,0.0015759807,0.00012287716,0.0010296864,0.000044368062,0.00077247847,0.23255618,0.002512317,0.06215548,0.6917124],"study_design_scores_gemma":[0.0050190384,0.021164896,0.022209242,0.0006892322,0.00046532755,0.008900018,0.000106319836,0.0045443536,0.3475128,0.0017374238,0.5875736,0.00007767784],"about_ca_topic_score_codex":0.0007529979,"about_ca_topic_score_gemma":0.001712352,"teacher_disagreement_score":0.01099336,"about_ca_system_score_codex":0.00042540723,"about_ca_system_score_gemma":0.0003611856,"threshold_uncertainty_score":0.036776483},"labels":[],"label_agreement":null},{"id":"W3006756276","doi":"10.1016/j.neurobiolaging.2020.02.006","title":"HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI","year":2020,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"Wings for Life","keywords":"PTEN; Neuroscience; Tensin; Axon; Biology; Epigenetics; Gap-43 protein; Endocrinology; Internal medicine; Cell biology; PI3K/AKT/mTOR pathway; Immunology; Medicine; Signal transduction; Genetics","score_opus":0.012056631990286481,"score_gpt":0.27182566191571605,"score_spread":0.25976902992542955,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3006756276","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99404776,0.0012009242,0.0012590655,0.0001808277,0.00017399754,0.00003814335,0.00080531987,0.00022048209,0.002073565],"genre_scores_gemma":[0.99083763,0.0009711283,0.00087198435,0.00010214772,0.000027762697,0.00008277809,0.00079198607,0.000045054883,0.006269585],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99959975,0.000027272077,0.000049632166,0.0000868946,0.00008019012,0.00015624614],"domain_scores_gemma":[0.9995472,0.000048217717,0.00011609155,0.000046620567,0.00003892943,0.00020296621],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003818235,0.0008019143,0.0007981113,0.00066129776,0.00030303726,0.00041572336,0.0006688923,0.0006996175,0.0037755514],"category_scores_gemma":[0.00029482692,0.00031262566,0.00085179205,0.0003112787,0.0008496766,0.0007423752,0.00046237785,0.0017893618,0.0007035388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008093798,0.0001267919,0.00015629483,0.00009903469,0.000017198361,0.0002228423,0.00004814516,0.00010560734,0.996856,0.00022825004,0.00010651229,0.0012238813],"study_design_scores_gemma":[0.00006214653,0.0010047817,0.006423392,0.000016996268,0.00005285446,0.0002645618,0.00014249572,0.00068183796,0.99008614,0.00011977459,0.001131895,0.000013021404],"about_ca_topic_score_codex":0.0020180629,"about_ca_topic_score_gemma":0.002788031,"teacher_disagreement_score":0.0037755514,"about_ca_system_score_codex":0.00038012632,"about_ca_system_score_gemma":0.0006419133,"threshold_uncertainty_score":0.012630403},"labels":[],"label_agreement":null},{"id":"W3007183689","doi":"10.1016/j.kint.2020.01.029","title":"Connectivity mapping of a chronic kidney disease progression signature identified lysine deacetylases as novel therapeutic targets","year":2020,"lang":"en","type":"article","venue":"Kidney International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto General Hospital; University Health Network; Toronto Rehabilitation Institute; University of Toronto","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Kidney disease; Lysine; Signature (topology); Disease; Medicine; Biology; Computational biology; Cancer research; Bioinformatics; Pathology; Internal medicine; Genetics; Amino acid","score_opus":0.018765325656545043,"score_gpt":0.3040742068170449,"score_spread":0.28530888116049985,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3007183689","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93892807,0.0014169338,0.047919586,0.0006362196,0.00006869042,0.00006479699,0.0047901375,0.00049648155,0.005679022],"genre_scores_gemma":[0.98353267,0.0004988725,0.012741816,0.00006304256,0.000021961445,0.000049465823,0.001800889,0.00004869136,0.0012425347],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994683,0.000005837447,0.0000025012603,0.000018881035,0.000013174778,0.000012710567],"domain_scores_gemma":[0.9998907,0.00002651286,0.000031129213,0.000008138946,0.000022023198,0.000021456113],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115161885,0.00024184723,0.0002755598,0.0005633979,0.00026443292,0.00039681513,0.00021345585,0.00019519356,0.0023210978],"category_scores_gemma":[0.00037752578,0.000092410206,0.00036420533,0.00061565754,0.00013821585,0.0002380798,0.00026030082,0.00032244573,0.0002699626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017069345,0.00021603394,0.10055434,0.0007895477,0.0008625093,0.0015110681,0.0003770004,0.020054443,0.6324933,0.009288027,0.008521156,0.22362566],"study_design_scores_gemma":[0.00021742308,0.000890761,0.70030224,0.00015311255,0.0010848773,0.003987847,0.0005002746,0.14110914,0.10440769,0.023498587,0.023715828,0.00013224667],"about_ca_topic_score_codex":0.003495447,"about_ca_topic_score_gemma":0.0060194004,"teacher_disagreement_score":0.003495447,"about_ca_system_score_codex":0.0003322487,"about_ca_system_score_gemma":0.00046981993,"threshold_uncertainty_score":0.0077648163},"labels":[],"label_agreement":null},{"id":"W3014446514","doi":"","title":"Induction of an anti-angiogenesis factor, Thrombospondin 1 (TSP-1), by a novel histone deacetylase inhibitor, MGCD0103, in human cancer cells in vitro and in vivo","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Angiogenesis; Cancer research; Thrombospondin 1; Histone deacetylase inhibitor; Cancer; Peripheral blood mononuclear cell; Medicine; In vitro; Histone deacetylase; Biology; Internal medicine; Histone; Biochemistry","score_opus":0.05304892397541062,"score_gpt":0.3840525661258173,"score_spread":0.3310036421504067,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3014446514","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9953603,0.0017027046,0.001413659,0.000068871464,0.000028149096,0.000046617966,0.00042369016,0.0000699529,0.0008860155],"genre_scores_gemma":[0.99460644,0.0010684741,0.0014047367,0.000058959497,0.000009689221,0.00005374501,0.0012985361,0.000009202917,0.0014901916],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998989,0.000016882306,0.000007826869,0.0000220661,0.000028372235,0.000025863954],"domain_scores_gemma":[0.9999536,0.000010204797,0.000009890452,0.000005907582,0.000006201984,0.000014207034],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012679893,0.00028897898,0.00028747722,0.00023728344,0.00012609598,0.00019110266,0.00013592755,0.00015482047,0.0008031693],"category_scores_gemma":[0.00007440565,0.00014663122,0.00025520026,0.00019028463,0.00014907426,0.00005912509,0.00009570241,0.000453365,0.00017726564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003087025,0.00013344472,0.00031826884,0.000035114117,0.0000096764325,0.000026827482,0.000020973255,0.0001262468,0.99601513,0.000030059797,0.000120814475,0.0028547111],"study_design_scores_gemma":[0.00010822871,0.0021873123,0.007797448,0.0000035138607,0.000030756117,0.00020645362,0.000021466072,0.0011977188,0.98591226,0.000018983545,0.0025127789,0.0000029872074],"about_ca_topic_score_codex":0.0021690682,"about_ca_topic_score_gemma":0.0041067884,"teacher_disagreement_score":0.0021690682,"about_ca_system_score_codex":0.00030765534,"about_ca_system_score_gemma":0.00035157803,"threshold_uncertainty_score":0.004312873},"labels":[],"label_agreement":null},{"id":"W3017115502","doi":"10.1096/fasebj.2020.34.s1.03646","title":"Role of Histone Deacetylases 5 (HDAC5) in Ang II‐Induced the Early Growth Response Protein‐1 (Egr‐1) Expression and Vascular Hypertrophy","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Gene silencing; Histone deacetylase 5; Angiotensin II; Vascular smooth muscle; Histone; Cell biology; Downregulation and upregulation; Transcription factor; Phosphorylation; Chemistry; Histone deacetylase; Biology; Endocrinology; Internal medicine; Cancer research; Biochemistry; Medicine","score_opus":0.01292996381406028,"score_gpt":0.25883657367377605,"score_spread":0.24590660985971577,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3017115502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9304435,0.056736987,0.0064943675,0.00052051945,0.00026590578,0.000058836533,0.00064052653,0.00017108445,0.00466835],"genre_scores_gemma":[0.9881194,0.0076669627,0.001269184,0.0001582085,0.00003228261,0.000021092594,0.00048143836,0.000009197735,0.0022422115],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990785,0.000013465594,0.000009459963,0.000018991268,0.000019006868,0.00003133503],"domain_scores_gemma":[0.99996185,0.0000032616917,0.000013571602,0.0000029181845,0.000005502144,0.000012880227],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013347906,0.00037585292,0.0002664385,0.00017744642,0.00018759107,0.00025501664,0.00021226775,0.0002467567,0.0010171714],"category_scores_gemma":[0.00006195761,0.00013345997,0.00042402925,0.00012775211,0.0002050718,0.00019197546,0.00018559472,0.00044546035,0.00024202508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005402851,0.00006571677,0.0020811998,0.0003574491,0.00006561226,0.00027130503,0.000044055403,0.00017818768,0.98798984,0.00059104926,0.00028938276,0.0075258655],"study_design_scores_gemma":[0.00013799297,0.0007701248,0.077298746,0.0000695118,0.00026170982,0.0011269163,0.0001904766,0.0024634663,0.899929,0.0003199327,0.017408261,0.000023941511],"about_ca_topic_score_codex":0.0010478082,"about_ca_topic_score_gemma":0.0015877684,"teacher_disagreement_score":0.0010478082,"about_ca_system_score_codex":0.0003443097,"about_ca_system_score_gemma":0.00023281087,"threshold_uncertainty_score":0.0034028292},"labels":[],"label_agreement":null},{"id":"W3022322095","doi":"10.1124/mol.120.119909","title":"Inhibition of Brain Epidermal Growth Factor Receptor Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries","year":2020,"lang":"en","type":"review","venue":"Molecular Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Neuroprotection; Medicine; Neurodegeneration; Epidermal growth factor receptor; EGFR inhibitors; Neuroscience; Amyotrophic lateral sclerosis; Disease; Multiple sclerosis; Receptor; Pathology; Pharmacology; Internal medicine; Immunology; Biology","score_opus":0.022441301718759566,"score_gpt":0.3398319508523709,"score_spread":0.3173906491336113,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3022322095","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00019704962,0.99690825,0.00041455266,0.0003271692,0.0004402608,0.0000098896,0.000049714443,0.000024002216,0.0016291298],"genre_scores_gemma":[0.0011252534,0.9964798,0.00038845776,0.00032716338,0.0002196253,0.000012308207,0.00006966042,0.0000034073148,0.0013743094],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999,0.0000125936585,0.000010543772,0.00002004378,0.00004108279,0.000015802374],"domain_scores_gemma":[0.9998883,0.000039296465,0.00002076335,0.0000045833926,0.000029125777,0.00001796935],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042192146,0.0012024833,0.0014459691,0.0011836269,0.00018218812,0.00082912453,0.00083789835,0.000955082,0.0036734599],"category_scores_gemma":[0.00037968796,0.00026454436,0.00041101285,0.0014243427,0.0003885601,0.0009618445,0.00045772348,0.0024560483,0.0029121188],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026065248,0.00013943967,0.00010023999,0.009966093,0.00011726733,0.00019286969,0.000024143328,0.00053666503,0.006009939,0.004219002,0.047944438,0.93048936],"study_design_scores_gemma":[0.000103516904,0.00021133605,0.00058061496,0.001219294,0.00018868207,0.0006929495,0.000023513803,0.00017291008,0.0016056859,0.0018922201,0.99328774,0.000021612534],"about_ca_topic_score_codex":0.0008012215,"about_ca_topic_score_gemma":0.0021552509,"teacher_disagreement_score":0.0036734599,"about_ca_system_score_codex":0.00055690674,"about_ca_system_score_gemma":0.0006902076,"threshold_uncertainty_score":0.012288988},"labels":[],"label_agreement":null},{"id":"W3026856873","doi":"10.1016/j.reprotox.2020.05.008","title":"Role of Cbp, p300 and Akt in valproic acid induced neural tube defects in CD-1 mouse embryos","year":2020,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Neural tube; Protein kinase B; Valproic Acid; Offspring; Embryo; PI3K/AKT/mTOR pathway; Biology; Endocrinology; Embryogenesis; Andrology; Internal medicine; Medicine; Cell biology; Signal transduction; Pregnancy; Neuroscience; Genetics; Epilepsy","score_opus":0.018404962138542164,"score_gpt":0.27736046965470135,"score_spread":0.2589555075161592,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3026856873","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99008137,0.0031334483,0.002078283,0.000309128,0.000054739143,0.00002664742,0.0008855471,0.00013207548,0.0032987602],"genre_scores_gemma":[0.9858425,0.0011222424,0.001962237,0.00007055098,0.000009037659,0.000041180134,0.00046483125,0.000059071586,0.0104283225],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998104,0.000021145794,0.000019803916,0.00005499819,0.00005010628,0.000043621858],"domain_scores_gemma":[0.99976534,0.00003435212,0.00006790675,0.000021946475,0.000021129563,0.00008930568],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016712923,0.00039741007,0.00025094455,0.0009356345,0.0003706888,0.0005005195,0.00045758823,0.00051750155,0.0023068278],"category_scores_gemma":[0.00016937134,0.00037974893,0.0002792655,0.00018267012,0.00044609376,0.0003855838,0.00027758733,0.0010572603,0.0003961709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028951775,0.000017398354,0.00023639308,0.000019959642,0.0000043997393,0.00017805926,0.000014898115,0.00004331712,0.99808705,0.000283557,0.00003227299,0.00079324876],"study_design_scores_gemma":[0.00004188567,0.00012508567,0.0065313866,0.000012534941,0.00002700368,0.0005483892,0.00006851953,0.00062360027,0.9900946,0.00015263433,0.0017676535,0.000006766112],"about_ca_topic_score_codex":0.0022769547,"about_ca_topic_score_gemma":0.0033242078,"teacher_disagreement_score":0.0023068278,"about_ca_system_score_codex":0.00058531814,"about_ca_system_score_gemma":0.0004380851,"threshold_uncertainty_score":0.007717073},"labels":[],"label_agreement":null},{"id":"W3027458352","doi":"10.1097/mph.0000000000001824","title":"Failure of Romidepsin to Treat Relapsed/Refractory Peripheral T-Cell Lymphoma in Children: A Single-center Experience","year":2020,"lang":"en","type":"letter","venue":"Journal of Pediatric Hematology/Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Romidepsin; Refractory (planetary science); Single Center; Peripheral T-cell lymphoma; Lymphoma; Center (category theory); Peripheral; Oncology; Internal medicine; Pediatrics; Immunology; T cell","score_opus":0.01436359609565796,"score_gpt":0.2774147452066413,"score_spread":0.2630511491109833,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3027458352","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97189593,0.011058583,0.002484999,0.0054911124,0.0003661553,0.00010979264,0.0003820747,0.0000932978,0.008118162],"genre_scores_gemma":[0.98856235,0.005034554,0.0011993558,0.0027625808,0.00032080253,0.000043979064,0.0004315431,0.0000638324,0.0015810184],"study_design_codex":"case_report","study_design_gemma":"observational","domain_scores_codex":[0.999729,0.000070155475,0.000040692576,0.000042543736,0.000043235385,0.00007441592],"domain_scores_gemma":[0.9991743,0.00029254903,0.00013049657,0.00005755679,0.000048733393,0.00029625904],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036896917,0.00051068,0.0007490291,0.00019276548,0.0005990312,0.00062160695,0.0004637431,0.0011831394,0.0007922967],"category_scores_gemma":[0.0014586054,0.00017698511,0.0007803415,0.00038596056,0.0004535792,0.00046651933,0.0003426423,0.0013049727,0.00045210592],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003262954,0.0017185683,0.21228512,0.00060070626,0.0006065689,0.5113874,0.002497418,0.0024020849,0.014109445,0.0015668797,0.020402286,0.22916064],"study_design_scores_gemma":[0.0012413508,0.00976108,0.17526785,0.0002362178,0.0004400228,0.76493466,0.000906541,0.0015058088,0.0077417754,0.00072230963,0.037170805,0.0000716298],"about_ca_topic_score_codex":0.0011744876,"about_ca_topic_score_gemma":0.0021565508,"teacher_disagreement_score":0.0011831394,"about_ca_system_score_codex":0.00089358183,"about_ca_system_score_gemma":0.0005323229,"threshold_uncertainty_score":0.006483376},"labels":[],"label_agreement":null},{"id":"W3028102427","doi":"10.1080/23723556.2020.1761243","title":"Targeting neurolysin in acute myeloid leukemia","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Myeloid leukemia; Oxidative metabolism; In vivo; Myeloid; Oxidative phosphorylation; Cancer research; Leukemia; Respiratory chain; In vitro; Biology; Mitochondrion; Chemistry; Metabolism; Immunology; Cell biology; Biochemistry; Genetics","score_opus":0.010883645801370889,"score_gpt":0.268028090341683,"score_spread":0.2571444445403121,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3028102427","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9847172,0.007089033,0.0043128105,0.00042213558,0.0000472022,0.00008005777,0.0004222026,0.00016257704,0.0027467392],"genre_scores_gemma":[0.9882637,0.0049665864,0.003449109,0.00010268791,0.000009932045,0.000026714164,0.00044122452,0.00001533944,0.0027247681],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999256,0.000009843756,0.000005274835,0.000010882586,0.000029864603,0.000018509678],"domain_scores_gemma":[0.999966,0.000004482249,0.000009780297,0.000002134762,0.0000060853395,0.000011444733],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011473091,0.0002768998,0.0002232192,0.00017900117,0.00011311587,0.00026401825,0.00017086041,0.00020104018,0.0005405433],"category_scores_gemma":[0.00006133178,0.000092103524,0.0001193575,0.00012915544,0.00016836128,0.00010338547,0.00021863381,0.00039790402,0.00024553516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001632054,0.000030214158,0.0003599958,0.000050533225,0.000008678042,0.00014601664,0.000010833234,0.0003831209,0.9926893,0.00017995981,0.00014344991,0.005834667],"study_design_scores_gemma":[0.00007089287,0.0007026797,0.0025741062,0.0000072297557,0.000029568842,0.00067164784,0.000027113614,0.0016974937,0.98524576,0.000119515586,0.0088465875,0.000007404847],"about_ca_topic_score_codex":0.0010041331,"about_ca_topic_score_gemma":0.0028356763,"teacher_disagreement_score":0.0010041331,"about_ca_system_score_codex":0.000517162,"about_ca_system_score_gemma":0.00021538106,"threshold_uncertainty_score":0.0037522912},"labels":[],"label_agreement":null},{"id":"W3034152397","doi":"10.1016/j.ejmech.2020.112411","title":"PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society; Ontario Research Foundation","keywords":"Chemistry; HDAC6; Druggability; Cancer research; Pharmacology; Histone deacetylase; Biochemistry; Biology; Histone","score_opus":0.02043275046612374,"score_gpt":0.28005990550090676,"score_spread":0.259627155034783,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3034152397","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86624414,0.089520834,0.0072094915,0.0035658865,0.0016113765,0.0008625328,0.0027360374,0.0013845504,0.026865179],"genre_scores_gemma":[0.93606746,0.041112036,0.0055936514,0.0017378709,0.0002537206,0.0003124384,0.0039796424,0.00006855308,0.010874665],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990785,0.000013366768,0.000009393813,0.000017471766,0.000018801902,0.000033016375],"domain_scores_gemma":[0.999962,0.0000026582845,0.0000057114908,0.000003871719,0.000005009321,0.000020790003],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025673164,0.00052824774,0.0008961837,0.00035997486,0.00023480807,0.00045762095,0.0005729585,0.00057743036,0.0030677305],"category_scores_gemma":[0.00013175937,0.00017176944,0.00040533044,0.00053716043,0.0002682288,0.0003440221,0.00037274926,0.0016766869,0.0013341011],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00832338,0.00244942,0.0021285,0.0019495498,0.00034861354,0.001716197,0.0001815938,0.0033845915,0.4393699,0.004098587,0.024590285,0.5114594],"study_design_scores_gemma":[0.02656363,0.062217526,0.027221791,0.00044879594,0.0013196841,0.014823892,0.00020831794,0.008292532,0.43870392,0.0034385526,0.41649452,0.00026677552],"about_ca_topic_score_codex":0.00053197675,"about_ca_topic_score_gemma":0.0013774899,"teacher_disagreement_score":0.0030677305,"about_ca_system_score_codex":0.0003599241,"about_ca_system_score_gemma":0.0005243409,"threshold_uncertainty_score":0.0102626085},"labels":[],"label_agreement":null},{"id":"W3034420322","doi":"10.22541/au.158931086.64128149","title":"Valproic Acid in Prevention and Treatment of COVID-19","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Valproic Acid; Coronavirus disease 2019 (COVID-19); Coronavirus; Inflammation; Drug; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pharmacology; Mechanism (biology); Drug repositioning; 2019-20 coronavirus outbreak; Bioinformatics; Immunology; Internal medicine; Biology; Virology; Epilepsy; Psychiatry; Disease","score_opus":0.049099009922125326,"score_gpt":0.3651960536159105,"score_spread":0.31609704369378516,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3034420322","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.2537421,0.7198384,0.0023831425,0.0058873026,0.001665957,0.000120448756,0.00075900863,0.0002513067,0.015352343],"genre_scores_gemma":[0.778379,0.20350742,0.004152413,0.0017438451,0.0008332406,0.00007887951,0.00089274393,0.00005599271,0.010356411],"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","domain_scores_codex":[0.9998735,0.00004699515,0.00001544468,0.000017355618,0.000027187138,0.000019383484],"domain_scores_gemma":[0.99993205,0.000011624943,0.00001815703,0.000006583841,0.000010580302,0.000021065838],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024127925,0.00025448352,0.0004072888,0.00031830225,0.000114315495,0.0003391776,0.00023643498,0.00041592016,0.0017414868],"category_scores_gemma":[0.00023221473,0.00006273155,0.00033480485,0.00021680581,0.00020239614,0.0001933112,0.00020925645,0.0008170833,0.0005207818],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.029119048,0.0019935672,0.004638672,0.0037549422,0.00089858274,0.0024535472,0.00015446836,0.0011510188,0.10063136,0.004415903,0.015015952,0.8357729],"study_design_scores_gemma":[0.013681284,0.031305782,0.08674809,0.0022798823,0.0016511255,0.015653592,0.00038781494,0.0030338597,0.20842035,0.011312082,0.6254148,0.00011128231],"about_ca_topic_score_codex":0.00043157907,"about_ca_topic_score_gemma":0.00070437544,"teacher_disagreement_score":0.0017414868,"about_ca_system_score_codex":0.00027440707,"about_ca_system_score_gemma":0.00039272633,"threshold_uncertainty_score":0.005825877},"labels":[],"label_agreement":null},{"id":"W3036185872","doi":"10.3390/cancers12061664","title":"Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Histone Acetyltransferases; Histone; Acetylation; Chromatin; Epigenetics; Cancer epigenetics; Biology; Histone deacetylase; Histone-modifying enzymes; Cell biology; Chromatin remodeling; Cancer research; Histone methyltransferase; Genetics; Gene","score_opus":0.030676581527039577,"score_gpt":0.3753251756396718,"score_spread":0.34464859411263227,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3036185872","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009419346,0.99808204,0.00012814501,0.00024887867,0.00031439017,0.0000057326138,0.000015242103,0.000008433318,0.0011029236],"genre_scores_gemma":[0.0007008121,0.9975351,0.00020240703,0.00023386706,0.0002502131,0.000009825487,0.000031994976,0.000002236981,0.0010335856],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997445,0.00004931378,0.000029902934,0.000042280033,0.00010589719,0.00002801285],"domain_scores_gemma":[0.9997923,0.00009473789,0.000025105815,0.000009037447,0.000054762146,0.000024068026],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005952853,0.0009134936,0.0012828093,0.0019579206,0.0002702322,0.0009221691,0.0010001084,0.0010385058,0.004386518],"category_scores_gemma":[0.000644561,0.0002668028,0.0005907774,0.0017273016,0.0005159899,0.0013288187,0.0006655402,0.0026973048,0.0025000302],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000118253505,0.00013214418,0.00012172057,0.011562968,0.000110593974,0.00029316632,0.000060722097,0.0004976938,0.002663272,0.0070656417,0.052908666,0.9244652],"study_design_scores_gemma":[0.000022312848,0.000088156165,0.00035155454,0.0013913995,0.00006211001,0.00079788227,0.000021032587,0.00007684037,0.00043408707,0.0016729395,0.9950706,0.0000110974615],"about_ca_topic_score_codex":0.00064858055,"about_ca_topic_score_gemma":0.0014340947,"teacher_disagreement_score":0.004386518,"about_ca_system_score_codex":0.0007949701,"about_ca_system_score_gemma":0.0007204761,"threshold_uncertainty_score":0.0146743655},"labels":[],"label_agreement":null},{"id":"W3041546786","doi":"10.3389/fcell.2020.00546","title":"Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"Fundação Instituto de Pesquisas Econômicas; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Brain Tumour Foundation of Canada","keywords":"Medulloblastoma; Histone deacetylase; Epigenetics; Medicine; Vorinostat; Cancer; Ependymoma; Pediatric cancer; Cancer research; Histone; Acetylation; Cancer epigenetics; Histone deacetylase inhibitor; Oncology; Bioinformatics; Internal medicine; Biology; Pathology; Genetics","score_opus":0.018359211503358782,"score_gpt":0.2919660180514365,"score_spread":0.27360680654807773,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3041546786","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00019580821,0.9982936,0.00011896513,0.00021927724,0.0001284247,0.000005877511,0.000035642563,0.000012079781,0.0009904263],"genre_scores_gemma":[0.00082690065,0.99808455,0.00017887459,0.00017014163,0.000089399895,0.000008765039,0.000053232838,0.0000024763042,0.00058560306],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998975,0.000016734424,0.000014224252,0.00002029598,0.000036985373,0.000014361184],"domain_scores_gemma":[0.9998223,0.000080316204,0.00002607647,0.0000053239564,0.00004357481,0.000022326456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004170251,0.00065596355,0.0009637562,0.0014714929,0.00017907868,0.000718475,0.0006564579,0.00077452,0.003703651],"category_scores_gemma":[0.00048775805,0.0002172671,0.0004773697,0.0013130321,0.00026173674,0.00082293706,0.00047588834,0.0017739986,0.0021934344],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011907597,0.00007962897,0.00014061495,0.009469458,0.000087237815,0.00018415922,0.000038570295,0.00035316966,0.0026914957,0.0029262786,0.026110955,0.9577995],"study_design_scores_gemma":[0.00004454091,0.00019787741,0.0006794837,0.0019220144,0.00013854362,0.0011164509,0.00003162794,0.00011238494,0.001034743,0.0014620952,0.993244,0.000016277905],"about_ca_topic_score_codex":0.00061120134,"about_ca_topic_score_gemma":0.0017190219,"teacher_disagreement_score":0.003703651,"about_ca_system_score_codex":0.0004490917,"about_ca_system_score_gemma":0.0005627799,"threshold_uncertainty_score":0.012389958},"labels":[],"label_agreement":null},{"id":"W3043806255","doi":"10.1021/acs.jmedchem.0c01025","title":"Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; Ontario Research Foundation; Canada Foundation for Innovation; Canadian Cancer Society","keywords":"HDAC8; Chemistry; In vitro; Stereochemistry; Histone; Biochemistry; Histone deacetylase; Gene","score_opus":0.009670487799964175,"score_gpt":0.25353567378689373,"score_spread":0.24386518598692955,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3043806255","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98268026,0.0027724137,0.008487121,0.0001323206,0.000036616773,0.00021654091,0.0005790135,0.0001345721,0.004961119],"genre_scores_gemma":[0.98666996,0.0018472935,0.008107318,0.00007159695,0.000012503895,0.00011159267,0.0007932194,0.00003420046,0.002352254],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998927,0.000019794312,0.000006630637,0.000019860589,0.000036282396,0.0000247444],"domain_scores_gemma":[0.9999225,0.00001763709,0.000021611724,0.000006763577,0.000013897415,0.000017566423],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019392134,0.00037750672,0.00030495328,0.00009676838,0.00012200194,0.00023360513,0.00035163836,0.0002172764,0.0016221182],"category_scores_gemma":[0.00028147828,0.00014324894,0.00019542503,0.00011421808,0.00014769431,0.00018169543,0.00013966337,0.00036958454,0.00049174926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036410193,0.00021581874,0.00027348913,0.00024248773,0.000026177191,0.00013394881,0.00004571622,0.009557884,0.97765976,0.0009536051,0.00041114318,0.010115858],"study_design_scores_gemma":[0.00017831208,0.0019174808,0.0009736545,0.000021013255,0.000028020597,0.00017078676,0.000032455795,0.010787425,0.9790958,0.00012592884,0.006641124,0.000028015253],"about_ca_topic_score_codex":0.0008109798,"about_ca_topic_score_gemma":0.0018210991,"teacher_disagreement_score":0.0016221182,"about_ca_system_score_codex":0.00039454477,"about_ca_system_score_gemma":0.00023445975,"threshold_uncertainty_score":0.005426526},"labels":[],"label_agreement":null},{"id":"W3044309515","doi":"10.1016/j.yexcr.2020.112189","title":"Corrigendum to “Tissue inhibitor of metalloproteinase 1 suppresses growth and differentiation of osteoblasts and osteoclasts by targeting the AKT pathway” [Exp. Cell Res. 389 (2020) 111930–11940]","year":2020,"lang":"en","type":"erratum","venue":"Experimental Cell Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Cell biology; Protein kinase B; Tissue inhibitor of metalloproteinase; Cell growth; Metalloproteinase; Cancer research; Matrix metalloproteinase; Signal transduction; Biochemistry","score_opus":0.017069624467394098,"score_gpt":0.29083588916477054,"score_spread":0.27376626469737647,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3044309515","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000082543935,0.0026070762,0.0003236655,0.026723271,0.9589304,0.000051884996,0.0008862867,0.000327797,0.0100669945],"genre_scores_gemma":[0.003546687,0.011567801,0.001849007,0.07419928,0.29615444,0.00018372922,0.004303293,0.0006139612,0.60758173],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9970072,0.00023763308,0.00039549934,0.00041328082,0.0016226277,0.00032383777],"domain_scores_gemma":[0.9914833,0.0012754585,0.00046132196,0.00048656957,0.00549101,0.0008022642],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0019835362,0.0025511635,0.0030755466,0.004851297,0.0031677778,0.0032037166,0.004253672,0.0066420347,0.16052683],"category_scores_gemma":[0.011309083,0.0014819899,0.0029427148,0.0025086782,0.0013135186,0.0015649266,0.0019822093,0.005413972,0.098291725],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003274275,0.000013021421,0.000023308714,0.000092592796,0.000011114225,0.0001236177,0.0000034677905,0.000027516655,0.0001326438,0.00016854356,0.994706,0.004665562],"study_design_scores_gemma":[0.000047146717,0.000044151115,0.0010967812,0.00010432401,0.000047516674,0.00020388127,0.000014336777,0.00015016497,0.00064778473,0.0004020166,0.9972095,0.00003229013],"about_ca_topic_score_codex":0.021183325,"about_ca_topic_score_gemma":0.04023197,"teacher_disagreement_score":0.16052683,"about_ca_system_score_codex":0.0043945997,"about_ca_system_score_gemma":0.004001633,"threshold_uncertainty_score":0.53701574},"labels":[],"label_agreement":null},{"id":"W3044337858","doi":"10.1016/s2055-6640(20)30981-x","title":"36 Dose-dependent effects of HDACi on T cell activation and HIV latency reversal","year":2016,"lang":"en","type":"article","venue":"Journal of Virus Eradication","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"","keywords":"Latency (audio); Chemistry; Pharmacology; Neuroscience; Cell biology; Medicine; Biology; Computer science; Telecommunications","score_opus":0.006154415096663647,"score_gpt":0.24895854801150852,"score_spread":0.24280413291484487,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3044337858","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97744614,0.010818552,0.0015161367,0.00048739507,0.0006215238,0.00015005961,0.0024936926,0.00035871728,0.006107782],"genre_scores_gemma":[0.98229194,0.0035136265,0.0018897721,0.000107427695,0.00008347198,0.00007510326,0.0013435053,0.000056418598,0.010638715],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997944,0.000029810264,0.000022352506,0.000035622525,0.000032391155,0.000085287254],"domain_scores_gemma":[0.9998858,0.000030633502,0.000013479069,0.000021686079,0.000013728885,0.00003465561],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017920371,0.0004492195,0.00057021703,0.00028679747,0.00024811958,0.0003751962,0.0005021043,0.00031538936,0.0072369175],"category_scores_gemma":[0.00022885225,0.0002343263,0.0004513332,0.0003887967,0.0004201124,0.00027284128,0.00018106228,0.0011511594,0.001237724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0060772216,0.000681225,0.00027070072,0.00017312574,0.00004006029,0.00008450061,0.000077024946,0.0004694371,0.9793209,0.0003587218,0.0010116105,0.011435489],"study_design_scores_gemma":[0.00022535934,0.0023572037,0.0018994777,0.000009626585,0.000041624477,0.00008296122,0.000034162713,0.0004830553,0.9904316,0.000093628296,0.004324791,0.00001639517],"about_ca_topic_score_codex":0.0028233458,"about_ca_topic_score_gemma":0.005732836,"teacher_disagreement_score":0.0072369175,"about_ca_system_score_codex":0.00042523752,"about_ca_system_score_gemma":0.00058718777,"threshold_uncertainty_score":0.024209917},"labels":[],"label_agreement":null},{"id":"W3045383806","doi":"10.1083/jcb.201901099","title":"HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions","year":2020,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Canadian Space Agency; AFM-Téléthon; Agence Nationale de la Recherche","keywords":"HDAC6; Acetylcholine receptor; Microtubule; Cell biology; Neuromuscular junction; Postsynaptic potential; Acetylation; Chemistry; Acetylcholine; Biology; Receptor; Neuroscience; Biochemistry; Endocrinology","score_opus":0.017810191658724026,"score_gpt":0.24650183602985665,"score_spread":0.22869164437113262,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3045383806","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98689306,0.007097708,0.0023540484,0.00016663676,0.000055369066,0.000014418258,0.00032940286,0.00009679172,0.0029926314],"genre_scores_gemma":[0.9945898,0.0016793612,0.0006834169,0.000027512839,0.00001558513,0.000007770313,0.00021802058,0.000016022175,0.0027625987],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998797,0.000015602534,0.000009988763,0.000029896286,0.000029484478,0.00003528867],"domain_scores_gemma":[0.99993074,0.000004366655,0.00001985625,0.0000051786515,0.000012607458,0.00002720436],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009462319,0.00023191252,0.00024773594,0.00020972926,0.00023942922,0.00035494068,0.00023965053,0.00023541039,0.0014159045],"category_scores_gemma":[0.000101410464,0.00014812886,0.00025580564,0.00011506716,0.0002165678,0.00021964112,0.00021215908,0.00031452492,0.0005708405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012222759,0.000011152604,0.00062821235,0.000032933993,0.0000067741316,0.000040327952,0.000009789138,0.000036591842,0.9975024,0.00012537424,0.00004896455,0.001435251],"study_design_scores_gemma":[0.000035113033,0.00018977058,0.06578074,0.0000123022055,0.00003594287,0.0003222668,0.00007794671,0.0017944154,0.92738265,0.00015408696,0.00420584,0.00000897241],"about_ca_topic_score_codex":0.000959644,"about_ca_topic_score_gemma":0.0019085993,"teacher_disagreement_score":0.0014159045,"about_ca_system_score_codex":0.00038318604,"about_ca_system_score_gemma":0.00014551153,"threshold_uncertainty_score":0.004736662},"labels":[],"label_agreement":null},{"id":"W3047153469","doi":"10.1002/sctm.20-0142","title":"The role of mitochondrial proteases in leukemic cells and leukemic stem cells","year":2020,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research","keywords":"Proteases; Biology; Stem cell; Protease; Mitochondrion; Myeloid leukemia; Mitochondrial respiratory chain; Cancer research; Cell biology; Biochemistry; Enzyme","score_opus":0.012750751139338623,"score_gpt":0.24125446300586806,"score_spread":0.22850371186652943,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3047153469","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.18642363,0.78415793,0.014041689,0.0031110928,0.0005863386,0.00007914522,0.00069641985,0.00019511367,0.010708613],"genre_scores_gemma":[0.6641971,0.32272443,0.0048054243,0.00071762595,0.00036104323,0.00006962278,0.00082597096,0.00002794703,0.006270764],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983335,0.00003423919,0.000018561013,0.000036268753,0.00005755791,0.000019969999],"domain_scores_gemma":[0.9998832,0.000017870378,0.00003778425,0.00000779482,0.00002729912,0.00002602906],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864111,0.00031866966,0.00035929313,0.00040500873,0.00017352379,0.00073044345,0.00017596692,0.000436614,0.00070561504],"category_scores_gemma":[0.00017874125,0.00008785132,0.00020852312,0.00035796693,0.0004145097,0.0004382018,0.00034407488,0.00056282873,0.00032594538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00067641126,0.000083618615,0.0036436934,0.0029909033,0.000112350324,0.0018763293,0.00030337105,0.0006456473,0.76407963,0.020009674,0.003546422,0.20203197],"study_design_scores_gemma":[0.00010653842,0.0008869972,0.018181218,0.00037657045,0.00016444799,0.0072120097,0.00045415468,0.0018565072,0.6708334,0.010919178,0.28896868,0.00004028957],"about_ca_topic_score_codex":0.00022008826,"about_ca_topic_score_gemma":0.00024643177,"teacher_disagreement_score":0.00073044345,"about_ca_system_score_codex":0.0005464637,"about_ca_system_score_gemma":0.00031687706,"threshold_uncertainty_score":0.0039649606},"labels":[],"label_agreement":null},{"id":"W3047616895","doi":"10.1158/1538-7445.pedca19-a53","title":"Abstract A53: Synergistic interaction of HDACi and PLK1i in Group 3 <i>MYC</i>-amplified medulloblastoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Cancer research; Medulloblastoma; Combination therapy; Cell culture; Cell cycle; Histone deacetylase inhibitor; Histone deacetylase; Cell; Biology; Histone; Pharmacology; Gene; Genetics","score_opus":0.06398248237271388,"score_gpt":0.39106994053472033,"score_spread":0.32708745816200646,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3047616895","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9950936,0.0020226317,0.0005057536,0.0000708669,0.00006264542,0.000044888573,0.00037171406,0.0000693167,0.0017585495],"genre_scores_gemma":[0.997253,0.0007541801,0.0005251193,0.000026572681,0.000011646324,0.000026574582,0.000387618,0.000008445525,0.0010068151],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989724,0.000013642847,0.000009997582,0.000020321639,0.00002970588,0.00002905992],"domain_scores_gemma":[0.9999652,0.0000052420855,0.0000071881873,0.0000039102074,0.000004079069,0.000014506322],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011021962,0.0003383197,0.00046346293,0.0002712847,0.00013675909,0.00021393753,0.00021382415,0.00016972637,0.0021983436],"category_scores_gemma":[0.00007339357,0.00010170284,0.0003635367,0.00017430568,0.00013657821,0.00012613663,0.00014776405,0.00035020345,0.00033823453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011341987,0.00030143867,0.000689903,0.000104198654,0.000043073454,0.00012951603,0.000019400144,0.00029277912,0.99061173,0.000050065773,0.00035989578,0.006263715],"study_design_scores_gemma":[0.00015894794,0.0039653517,0.007722679,0.000009051508,0.000114566734,0.00035459927,0.00003785414,0.0014108215,0.9833425,0.000023598885,0.0028529179,0.000007095902],"about_ca_topic_score_codex":0.0014598193,"about_ca_topic_score_gemma":0.002371164,"teacher_disagreement_score":0.0021983436,"about_ca_system_score_codex":0.0002783641,"about_ca_system_score_gemma":0.00020531128,"threshold_uncertainty_score":0.0073542},"labels":[],"label_agreement":null},{"id":"W3049131576","doi":"10.1158/1078-0432.ccr-20-1412","title":"Phase I and Pharmacokinetic Study of Romidepsin in Patients with Cancer and Hepatic Dysfunction: A National Cancer Institute Organ Dysfunction Working Group Study","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Romidepsin; Medicine; Pharmacokinetics; Cancer; Internal medicine; Cohort; Organ dysfunction; Adverse effect; Dosing; Malignancy; Oncology","score_opus":0.13290511353278187,"score_gpt":0.4682802849682226,"score_spread":0.3353751714354407,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3049131576","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9979842,0.00035226776,0.0002955043,0.00010679841,0.000010657951,0.00038038247,0.00024411456,0.000014106718,0.00061188877],"genre_scores_gemma":[0.9972709,0.00022653582,0.0007116302,0.00029049825,0.000032667685,0.0002592443,0.0008194478,0.0000066730186,0.00038233193],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.999511,0.00027992172,0.000029359875,0.00005919827,0.000072665425,0.000047884936],"domain_scores_gemma":[0.9992963,0.000101032754,0.00016497869,0.00010117178,0.00007343584,0.00026311833],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015239451,0.0005099885,0.00068790396,0.00013656166,0.00018182177,0.0004161155,0.00030435174,0.000361764,0.0009939082],"category_scores_gemma":[0.0009029516,0.00019682343,0.00045296957,0.0002427822,0.00034411674,0.00034248832,0.00022292399,0.001133053,0.0002427894],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.40397608,0.048709646,0.21531749,0.00062243897,0.0023605144,0.00096750853,0.0006631705,0.004887241,0.1390424,0.000367111,0.0066697574,0.17641659],"study_design_scores_gemma":[0.18667635,0.53840166,0.24335474,0.00003632433,0.00083058974,0.002271099,0.00013637112,0.0045343363,0.017148186,0.0002374814,0.0063163596,0.000056571575],"about_ca_topic_score_codex":0.000588546,"about_ca_topic_score_gemma":0.0010093311,"teacher_disagreement_score":0.0015239451,"about_ca_system_score_codex":0.00057420385,"about_ca_system_score_gemma":0.0011267536,"threshold_uncertainty_score":0.008059442},"labels":[],"label_agreement":null},{"id":"W3062186670","doi":"10.47307/gmc.2020.128.3.7","title":"A brief overview of cancer research in the elderly population","year":2020,"lang":"es","type":"article","venue":"Gaceta Médica de Caracas","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Humanities; Population; Art; Environmental health","score_opus":0.10571317045752121,"score_gpt":0.4244996879910614,"score_spread":0.3187865175335402,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3062186670","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0004743729,0.9806223,0.0006631334,0.008975451,0.0032508823,0.00009058778,0.0010468062,0.00007514289,0.004801297],"genre_scores_gemma":[0.0018224323,0.9869393,0.001143735,0.0029887757,0.004050533,0.00014192068,0.0009545243,0.000015117604,0.0019437182],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99762374,0.0007849993,0.00058375485,0.0003315598,0.00047671705,0.00019911972],"domain_scores_gemma":[0.99478346,0.0028260713,0.00060423976,0.00013391838,0.0011567426,0.00049565715],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0036796466,0.0010292861,0.0012609828,0.007218397,0.0007059551,0.0027439333,0.0009391539,0.0023359393,0.012789706],"category_scores_gemma":[0.0076037785,0.00046505476,0.0013518892,0.008392409,0.0005803049,0.0024910506,0.0017248254,0.0020599037,0.005549435],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023141828,0.000115947914,0.003801233,0.030838154,0.00016867748,0.00032890844,0.0003379821,0.0001999249,0.00070007413,0.0052942024,0.18812023,0.76986325],"study_design_scores_gemma":[0.000022136319,0.00014143504,0.007449888,0.014855219,0.00015977734,0.0011321431,0.00023207814,0.00004718966,0.00010590965,0.0021381702,0.9736918,0.000024189256],"about_ca_topic_score_codex":0.0049797553,"about_ca_topic_score_gemma":0.006010768,"teacher_disagreement_score":0.012789706,"about_ca_system_score_codex":0.002294306,"about_ca_system_score_gemma":0.0063328696,"threshold_uncertainty_score":0.042785823},"labels":[],"label_agreement":null},{"id":"W3080835754","doi":"10.1200/jco.2009.27.15_suppl.5064","title":"Phase Ib dose finding trial of intravenous panobinostat with docetaxel in patients with castration-resistant prostate cancer (CRPC)","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Juravinski Cancer Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Panobinostat; Docetaxel; Prostate cancer; Internal medicine; Neutropenia; Cohort; Febrile neutropenia; Clinical endpoint; Adverse effect; Oncology; Cancer; Chemotherapy; Clinical trial","score_opus":0.052424964516917465,"score_gpt":0.44028511698111555,"score_spread":0.3878601524641981,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3080835754","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99077576,0.0013973234,0.00046682774,0.0006792333,0.00017608094,0.0034881223,0.0009372686,0.00012282704,0.0019565735],"genre_scores_gemma":[0.98838055,0.0011125273,0.001500619,0.0010489855,0.00022469541,0.0031315354,0.0022575737,0.000025491758,0.0023179995],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99945086,0.00029558374,0.000026193024,0.00007918386,0.00004390763,0.000104225575],"domain_scores_gemma":[0.9989497,0.00017767336,0.0002141603,0.00007424398,0.000052819258,0.0005314704],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0019015019,0.0020375068,0.0021372542,0.0006672677,0.0005763032,0.0013049695,0.0011998273,0.0018289256,0.004002249],"category_scores_gemma":[0.0013117447,0.0007999532,0.0011702274,0.0007168821,0.0014449292,0.0008271537,0.0004946589,0.0041585932,0.0009973358],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.829764,0.08813618,0.0046508415,0.00057950086,0.00072761497,0.00021650773,0.00023972741,0.0032703727,0.014717661,0.00026042148,0.0032124368,0.054224778],"study_design_scores_gemma":[0.66090655,0.3317819,0.0037603234,0.000025035346,0.00016036464,0.000114317736,0.000029036915,0.00089199527,0.0010504021,0.00012277668,0.0011393642,0.000018066627],"about_ca_topic_score_codex":0.0020657778,"about_ca_topic_score_gemma":0.0043945555,"teacher_disagreement_score":0.004002249,"about_ca_system_score_codex":0.0015477475,"about_ca_system_score_gemma":0.002605421,"threshold_uncertainty_score":0.013388813},"labels":[],"label_agreement":null},{"id":"W3080862464","doi":"10.1101/2020.08.23.235499","title":"Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Health and Medical Research Council; Kids' Cancer Project; Peter MacCallum Cancer Centre; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canada Research Chairs; Cancer Council Victoria; Deutsche Forschungsgemeinschaft; Cancer Australia; Australian Cancer Research Foundation","keywords":"Panobinostat; Epigenetics; Cancer research; Reprogramming; Biology; Immunotherapy; Interferon; Immune system; Myeloid leukemia; Leukemia; Myeloid; Immunology; Histone deacetylase; Histone; Cell; Gene; Genetics","score_opus":0.017589147278412917,"score_gpt":0.25681928072130644,"score_spread":0.2392301334428935,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3080862464","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9587285,0.0022257103,0.02474988,0.00053413835,0.00016999335,0.00014707295,0.0012161112,0.00045207568,0.011776556],"genre_scores_gemma":[0.98845893,0.00059956004,0.0055686138,0.00010305061,0.000020042535,0.000046342884,0.00044299857,0.000042880765,0.004717639],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990106,0.000011060228,0.0000063380303,0.000022126203,0.000038704035,0.000020676433],"domain_scores_gemma":[0.999961,0.0000045919255,0.000010616986,0.000008072835,0.0000061362075,0.000009637972],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012750458,0.00015836251,0.0001820999,0.0001280033,0.00011296982,0.00029313547,0.00011395003,0.00018259158,0.0024275465],"category_scores_gemma":[0.00007409009,0.000102451944,0.00017201202,0.00012197089,0.00015266103,0.00011391331,0.00021689017,0.0004833736,0.00081354834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000058031444,0.000009070221,0.00015169314,0.0000152508255,0.0000027628387,0.000025840107,0.000007560002,0.00008054441,0.9965496,0.00046023013,0.00011110761,0.0025283024],"study_design_scores_gemma":[0.000028771788,0.00007778376,0.001745103,0.000003988444,0.000010256071,0.00015985493,0.000015225277,0.0013404231,0.9860173,0.00026089742,0.010338339,0.000002156588],"about_ca_topic_score_codex":0.00017168366,"about_ca_topic_score_gemma":0.00025989735,"teacher_disagreement_score":0.0024275465,"about_ca_system_score_codex":0.00029255863,"about_ca_system_score_gemma":0.00018253397,"threshold_uncertainty_score":0.008120954},"labels":[],"label_agreement":null},{"id":"W3107502971","doi":"10.1016/j.xhgg.2020.100015","title":"Missense substitutions at a conserved 14-3-3 binding site in HDAC4 cause a novel intellectual disability syndrome","year":2020,"lang":"en","type":"article","venue":"Human Genetics and Genomics Advances","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University Health Centre","funders":"Wellcome Trust","keywords":"Missense mutation; Intellectual disability; Genetics; Biology; Histone; Chromatin; Gene; Allele; Binding site; Loss function; Microcephaly; HDAC4; Mutation; Histone deacetylase; Phenotype","score_opus":0.039646142496672296,"score_gpt":0.29660328779022643,"score_spread":0.2569571452935541,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3107502971","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99678254,0.00022213737,0.0015124187,0.00010692486,0.00003635403,0.000035572157,0.00019671237,0.00007557267,0.0010316732],"genre_scores_gemma":[0.9977957,0.000110810935,0.0011452384,0.00008565901,0.00004404796,0.000011608772,0.00018505062,0.000016039612,0.00060589606],"study_design_codex":"case_report","study_design_gemma":"observational","domain_scores_codex":[0.9997074,0.000027964938,0.00003618428,0.0000812874,0.00009859593,0.00004848507],"domain_scores_gemma":[0.9996259,0.000105470914,0.00010916349,0.000020962187,0.00002232469,0.00011622144],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014105435,0.0015946894,0.00052092946,0.0011007435,0.0005572423,0.00029618267,0.00072695606,0.0008693438,0.002017147],"category_scores_gemma":[0.00064229633,0.00025870648,0.0006143891,0.00047773612,0.0008565415,0.00015536441,0.00074663106,0.00053183624,0.000334696],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008199386,0.0004188735,0.094007164,0.00021277997,0.00059269037,0.459589,0.0009755048,0.0009357614,0.41393492,0.0015179516,0.0012933116,0.02570215],"study_design_scores_gemma":[0.00033666115,0.0010519653,0.33983585,0.000056885357,0.0005234169,0.5978069,0.000431883,0.0025010495,0.05096358,0.00070909,0.0056921965,0.0000904263],"about_ca_topic_score_codex":0.0011535008,"about_ca_topic_score_gemma":0.0013431093,"teacher_disagreement_score":0.002017147,"about_ca_system_score_codex":0.0003306485,"about_ca_system_score_gemma":0.00027609,"threshold_uncertainty_score":0.0067480206},"labels":[],"label_agreement":null},{"id":"W3108409030","doi":"10.1038/s42003-020-01458-3","title":"A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Petroleum Technology Research Centre; National Natural Science Foundation of China; National Science Foundation","keywords":"SIRT3; Cancer research; Chemistry; Cell growth; Histone deacetylase; NAD+ kinase; Cell biology; Biology; Histone; Biochemistry; Sirtuin; Enzyme","score_opus":0.02379015940328446,"score_gpt":0.29593669797272504,"score_spread":0.2721465385694406,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3108409030","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930735,0.0016413339,0.0018245584,0.00019943052,0.00006294072,0.00003950286,0.0005306753,0.00024436813,0.0023836328],"genre_scores_gemma":[0.9928478,0.0010583217,0.0011462724,0.00007290005,0.00001669833,0.000026780963,0.00045337446,0.000023233422,0.00435472],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998952,0.000014864791,0.000008723705,0.000014303063,0.000032701966,0.000034198623],"domain_scores_gemma":[0.9998964,0.0000074761706,0.000036977995,0.00001021135,0.000008043327,0.00004093235],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000971181,0.00036216687,0.00019812884,0.00041810458,0.00012688783,0.0001946798,0.00021070358,0.00022339656,0.0016501939],"category_scores_gemma":[0.000052271258,0.000107898624,0.00023047661,0.00018633607,0.0002841517,0.00013732334,0.00010390424,0.0006188871,0.00049763976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027008727,0.00007306931,0.00017630968,0.000024558176,0.0000064886344,0.000041645944,0.000008071287,0.00004858486,0.99733526,0.00011340164,0.00005905623,0.0018432498],"study_design_scores_gemma":[0.00006033354,0.001378271,0.0022546668,0.000005339012,0.000019904603,0.00016753262,0.000025146854,0.00044898363,0.9925328,0.00005923778,0.0030438812,0.0000039592446],"about_ca_topic_score_codex":0.0005879962,"about_ca_topic_score_gemma":0.0011526358,"teacher_disagreement_score":0.0016501939,"about_ca_system_score_codex":0.00024115713,"about_ca_system_score_gemma":0.00026845827,"threshold_uncertainty_score":0.0055204034},"labels":[],"label_agreement":null},{"id":"W3109541685","doi":"10.1111/cas.14759","title":"<i>LPIN1</i> downregulation enhances anticancer activity of the novel HDAC/PI3K dual inhibitor FK‐A11","year":2020,"lang":"en","type":"article","venue":"Cancer Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Aging","funders":"Tohoku University","keywords":"Cytotoxicity; Histone deacetylase inhibitor; Downregulation and upregulation; PI3K/AKT/mTOR pathway; Pharmacology; Histone deacetylase; In vivo; Chemistry; Cancer research; Biology; In vitro; Biochemistry; Histone; Signal transduction; Gene","score_opus":0.023613473712618953,"score_gpt":0.30559173408972623,"score_spread":0.28197826037710727,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3109541685","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99010426,0.0023838435,0.002858121,0.00018644454,0.00006172269,0.00003059968,0.00042173007,0.00017205895,0.0037811485],"genre_scores_gemma":[0.9936435,0.0009710492,0.0018133976,0.00007425993,0.000012755475,0.000034344375,0.0005582622,0.00001630736,0.0028761018],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993277,0.000008345046,0.0000067189394,0.0000145150825,0.000015119921,0.000022536848],"domain_scores_gemma":[0.99997306,0.0000068903632,0.000006599676,0.0000026431012,0.0000030831573,0.000007771567],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006888547,0.0002523137,0.00023875742,0.00012814387,0.00009524484,0.00022864877,0.00011973231,0.00014675278,0.0011813089],"category_scores_gemma":[0.0000528272,0.00007771021,0.00016966004,0.00010633858,0.00013554908,0.00015891297,0.00007675491,0.00053296285,0.00028192706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015431814,0.00003951556,0.00009013375,0.000027760436,0.000004130303,0.000020765508,0.0000032080839,0.00007223219,0.99772793,0.000071531875,0.000117885174,0.0016706573],"study_design_scores_gemma":[0.0000117058335,0.00022770642,0.0015732562,0.0000014735843,0.000011330881,0.00007307597,0.0000055506302,0.00074261485,0.9954478,0.000011957378,0.0018916227,0.0000018910662],"about_ca_topic_score_codex":0.0006912335,"about_ca_topic_score_gemma":0.0012500653,"teacher_disagreement_score":0.0011813089,"about_ca_system_score_codex":0.00031823735,"about_ca_system_score_gemma":0.00016686966,"threshold_uncertainty_score":0.0039518476},"labels":[],"label_agreement":null},{"id":"W3119331783","doi":"10.1016/j.stem.2020.12.002","title":"UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Biology; Corepressor; Cell biology; Epigenetics; Ubiquitin ligase; Ex vivo; Ubiquitin; Haematopoiesis; Stem cell; In vivo; Genetics; Repressor; Transcription factor","score_opus":0.020254300635703527,"score_gpt":0.2563851877851877,"score_spread":0.2361308871494842,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3119331783","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930622,0.0019021278,0.0021115702,0.00016725007,0.0000754838,0.000018048888,0.0007112349,0.00013352981,0.0018185185],"genre_scores_gemma":[0.9957288,0.0004155407,0.0005844921,0.000044052653,0.000010133839,0.000018655377,0.00076509773,0.000034739875,0.0023984474],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988556,0.000020784451,0.000012409708,0.000022282622,0.000024123494,0.000034828292],"domain_scores_gemma":[0.9999056,0.000015406427,0.000020425467,0.000022262358,0.0000068415957,0.000029511855],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016417091,0.0002656152,0.000310905,0.00020088383,0.00019449372,0.00033861754,0.00024334327,0.00015072958,0.0024655564],"category_scores_gemma":[0.00013391071,0.00015797536,0.0002451464,0.00016931466,0.0002033308,0.00010605918,0.00022662747,0.0005641623,0.000628256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035520215,0.000039090948,0.00020992063,0.000027687587,0.000012475751,0.000034839704,0.000018526642,0.00006441456,0.99716645,0.00009464608,0.000099503646,0.0018772149],"study_design_scores_gemma":[0.000019720439,0.00015442252,0.0021637,0.0000032513926,0.000014280298,0.00007798425,0.000022066499,0.0001579935,0.9953283,0.000021114998,0.0020351356,0.0000020727905],"about_ca_topic_score_codex":0.00078113005,"about_ca_topic_score_gemma":0.0012468006,"teacher_disagreement_score":0.0024655564,"about_ca_system_score_codex":0.000214248,"about_ca_system_score_gemma":0.00027143682,"threshold_uncertainty_score":0.008248091},"labels":[],"label_agreement":null},{"id":"W3120517312","doi":"10.1182/blood.v130.suppl_1.269.269","title":"Inhibition of the Epigenetic Modifier EZH2 By Mir-138 Upregulates Tumor Suppressor Gene Rbpms and Contributes to Drug Susceptibility in Preclinical Model of Multiple Myeloma","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Epigenetics; Cancer research; EZH2; Multiple myeloma; microRNA; Gene; Suppressor; Tumor suppressor gene; Biology; Genetics; Molecular biology; Medicine; Immunology; Carcinogenesis","score_opus":0.01874335898611425,"score_gpt":0.2881021923290323,"score_spread":0.26935883334291805,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3120517312","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99316794,0.0015623359,0.0024169104,0.00030423788,0.000116690426,0.000030022102,0.0005172073,0.0003075867,0.0015771751],"genre_scores_gemma":[0.9950088,0.0007805106,0.0008174776,0.0000610634,0.000019944746,0.000038321068,0.000431764,0.000027771197,0.0028143448],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998042,0.000018882212,0.000013908286,0.00003144304,0.00007145461,0.00006001619],"domain_scores_gemma":[0.99990964,0.000008051776,0.000029777102,0.00001057612,0.000010882038,0.000031067637],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017521133,0.00040558478,0.0004313362,0.00044986123,0.00019895857,0.0003398139,0.00023859812,0.00022153063,0.0024147525],"category_scores_gemma":[0.00013502559,0.00018824005,0.00029087602,0.00025996278,0.00028445176,0.00026027352,0.00018609726,0.0012186059,0.00046075214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010552751,0.0002992128,0.00066440075,0.000045687964,0.000021008838,0.000064179905,0.000017290484,0.00009912574,0.9926738,0.00020397635,0.00028058919,0.0045752674],"study_design_scores_gemma":[0.00009323472,0.0013079904,0.004996967,0.000003634575,0.00006851788,0.0001708507,0.00003847572,0.00103261,0.98921096,0.00011776692,0.0029527787,0.000006123687],"about_ca_topic_score_codex":0.00069783727,"about_ca_topic_score_gemma":0.0011299669,"teacher_disagreement_score":0.0024147525,"about_ca_system_score_codex":0.00038677955,"about_ca_system_score_gemma":0.00034247557,"threshold_uncertainty_score":0.008078158},"labels":[],"label_agreement":null},{"id":"W3126781502","doi":"10.1038/s41419-021-03417-0","title":"HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China; National Science Foundation","keywords":"HDAC4; Nasopharyngeal carcinoma; Cancer research; Gene knockdown; Epithelial–mesenchymal transition; Biology; Tumor progression; Histone deacetylase; Metastasis; Downregulation and upregulation; HDAC1; Histone; Cell culture; Cancer; Medicine; Internal medicine; Radiation therapy","score_opus":0.010888078565585322,"score_gpt":0.27406934302933333,"score_spread":0.263181264463748,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3126781502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87250406,0.08557481,0.009943893,0.0017939733,0.00066801405,0.00027322245,0.0015800382,0.0009789246,0.026683003],"genre_scores_gemma":[0.974096,0.015599058,0.0017737751,0.0002016186,0.0000669603,0.000066563145,0.0008476617,0.000038378945,0.0073100054],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989724,0.00001565763,0.0000068216546,0.000018926701,0.000028378765,0.000032988926],"domain_scores_gemma":[0.9999598,0.0000038334742,0.000008695835,0.0000055351215,0.0000097757875,0.000012365971],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019205292,0.00041619167,0.00043327204,0.00034916654,0.00029347494,0.00044893014,0.0002739397,0.0002547005,0.0032355126],"category_scores_gemma":[0.00011066045,0.00014456695,0.00044943579,0.00030140267,0.00030291217,0.0001797875,0.00024646538,0.000677498,0.00085785653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011612297,0.00025028092,0.0037511615,0.00049254077,0.00011206521,0.0003602217,0.00004761904,0.00052956794,0.9444996,0.0011915892,0.002085776,0.04551835],"study_design_scores_gemma":[0.00022643083,0.0013246655,0.024595074,0.0000464775,0.0002574646,0.0010555828,0.00012994722,0.0029678782,0.9005029,0.00066133327,0.06820826,0.000024075718],"about_ca_topic_score_codex":0.00212087,"about_ca_topic_score_gemma":0.004067278,"teacher_disagreement_score":0.0032355126,"about_ca_system_score_codex":0.00091253855,"about_ca_system_score_gemma":0.0006119492,"threshold_uncertainty_score":0.0108239055},"labels":[],"label_agreement":null},{"id":"W3128160313","doi":"10.1021/acs.jmedchem.0c01922","title":"Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society; U.S. Department of Energy","keywords":"Chemistry; Chemotype; Histone deacetylase; Catalysis; Stereochemistry; Characterization (materials science); Molecular model; Histone; Computational chemistry; Biochemistry; Nanotechnology; Gene","score_opus":0.012203273150786226,"score_gpt":0.2753350814743428,"score_spread":0.2631318083235566,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3128160313","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9880123,0.0012433776,0.0065235924,0.00028763583,0.000042460168,0.000051769784,0.00045171787,0.00014292024,0.0032441923],"genre_scores_gemma":[0.9852284,0.0009735865,0.010198805,0.00010933266,0.000008824057,0.000043417745,0.0008142735,0.000019762187,0.002603539],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993634,0.0000061723154,0.0000023194266,0.000014880906,0.000021380454,0.0000189543],"domain_scores_gemma":[0.99994457,0.000009155843,0.000012636727,0.000004589582,0.0000070922865,0.000021981286],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010281672,0.00022620414,0.00027380494,0.000080378435,0.00018708003,0.00022644947,0.0005692336,0.00032361632,0.0015507732],"category_scores_gemma":[0.00013116305,0.00012096851,0.00020867646,0.000094273826,0.00020788508,0.00024611034,0.00018385766,0.00057116436,0.00028792405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046320166,0.00017515114,0.001330908,0.00018935157,0.000021421616,0.00047382904,0.000059255384,0.0049993084,0.9830593,0.0030056415,0.0008990379,0.005323607],"study_design_scores_gemma":[0.00033934828,0.0010154966,0.004401669,0.000028820663,0.000047925747,0.0012468578,0.00012280005,0.03601957,0.9383819,0.0009074717,0.017432207,0.000055886678],"about_ca_topic_score_codex":0.0015348867,"about_ca_topic_score_gemma":0.0015688624,"teacher_disagreement_score":0.0015507732,"about_ca_system_score_codex":0.00043259232,"about_ca_system_score_gemma":0.00058858155,"threshold_uncertainty_score":0.0051878095},"labels":[],"label_agreement":null},{"id":"W3130559842","doi":"10.1016/j.xcrm.2021.100202","title":"Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients","year":2021,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University; London Health Sciences Centre; McMaster University; Juravinski Hospital; University of Ottawa; Population Health Research Institute","funders":"Canadian Cancer Society Research Institute; Canada Research Chairs; McMaster University","keywords":"Myeloid leukemia; Haematopoiesis; Progenitor cell; Cancer research; Medicine; Drug repositioning; Leukemia; Pharmacology; Internal medicine; Stem cell; Biology; Drug; Cell biology","score_opus":0.0072241262899179984,"score_gpt":0.24801538647474683,"score_spread":0.24079126018482883,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3130559842","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98449427,0.0018038846,0.006315308,0.0005005437,0.000048164155,0.000052406594,0.0006271366,0.00017671681,0.0059815496],"genre_scores_gemma":[0.9963767,0.0005048309,0.0016230807,0.00011881871,0.000008002717,0.000015412847,0.00028965628,0.000012327725,0.00105113],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994457,0.000010057433,0.0000050966455,0.000012573843,0.000015959899,0.000011692891],"domain_scores_gemma":[0.9999534,0.000008258351,0.000011603382,0.000006878364,0.000003969704,0.000016011873],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010765864,0.00011609268,0.00016898951,0.00011970697,0.00010063787,0.00024897768,0.00012100243,0.00014252518,0.0017657821],"category_scores_gemma":[0.00014302674,0.000057813624,0.0000963906,0.00008088869,0.00010000344,0.00008292876,0.00018561097,0.00038066864,0.00035377793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00068444246,0.00011637334,0.0088431975,0.00005582243,0.00002430742,0.0006205552,0.00005871805,0.00043242564,0.941381,0.0011078904,0.0008935184,0.045781683],"study_design_scores_gemma":[0.00020628219,0.00157863,0.038316086,0.000014269392,0.00008634094,0.010249785,0.000118426375,0.003296435,0.90951127,0.0008360885,0.035771795,0.000014530114],"about_ca_topic_score_codex":0.0003577264,"about_ca_topic_score_gemma":0.00079447974,"teacher_disagreement_score":0.0017657821,"about_ca_system_score_codex":0.00021575966,"about_ca_system_score_gemma":0.00018672379,"threshold_uncertainty_score":0.0059071183},"labels":[],"label_agreement":null},{"id":"W3131234768","doi":"10.3390/curroncol28010091","title":"A Histone Acetylation Modulator Gene Signature for Classification and Prognosis of Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Acetylation; Histone; Breast cancer; Epigenetics; Cancer research; Cancer epigenetics; HDAC4; Medicine; Histone deacetylase 2; Gene; Biology; Histone H2A; Cancer; Computational biology; Genetics; Histone methyltransferase; Histone deacetylase","score_opus":0.07673060178725258,"score_gpt":0.4234210414252021,"score_spread":0.34669043963794954,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3131234768","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99220455,0.0020817847,0.0016067964,0.000086076216,0.000016603663,0.000027495322,0.0030420867,0.000052332834,0.0008823115],"genre_scores_gemma":[0.9954609,0.00034580237,0.0016589004,0.00003563065,0.00001288435,0.000014662406,0.0022007837,0.000006211669,0.00026417553],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9998467,0.00003365895,0.000014356319,0.00004092552,0.000035149435,0.000029224311],"domain_scores_gemma":[0.9996855,0.00010398672,0.00009152874,0.000029421739,0.000047648286,0.000041881976],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286942,0.00022716657,0.00039489605,0.0009794314,0.00016850566,0.00030995172,0.00013420716,0.00015993998,0.000833888],"category_scores_gemma":[0.0005847828,0.000055764613,0.00026795783,0.0009834816,0.00011483259,0.00012522606,0.00021455239,0.00017115929,0.00018318553],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00071423926,0.00003050603,0.90674245,0.00010387676,0.00026356053,0.00012078608,0.00003883527,0.00059591216,0.05823091,0.000058106423,0.00047071866,0.03263008],"study_design_scores_gemma":[0.0000140819775,0.00018023713,0.98754185,0.000016642658,0.00034318792,0.00044641076,0.00007289812,0.002269752,0.007383051,0.00015399467,0.0015687455,0.000009113685],"about_ca_topic_score_codex":0.0012841694,"about_ca_topic_score_gemma":0.004085417,"teacher_disagreement_score":0.0012841694,"about_ca_system_score_codex":0.00017100626,"about_ca_system_score_gemma":0.000272574,"threshold_uncertainty_score":0.0027896762},"labels":[],"label_agreement":null},{"id":"W3132748443","doi":"10.1016/b978-0-12-821310-0.00002-4","title":"Preventing phenotypic plasticity in cancer to mitigate therapy resistance","year":2021,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University; University of Alberta","funders":"","keywords":"Cancer therapy; Phenotypic plasticity; Resistance (ecology); Cancer; Plasticity; Medicine; Biology; Materials science; Genetics; Internal medicine; Ecology; Composite material","score_opus":0.01935925593065766,"score_gpt":0.288139613252676,"score_spread":0.2687803573220183,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3132748443","genre_codex":"other","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.030414939,0.31632227,0.029189235,0.008085188,0.0037909008,0.00010814772,0.0011336491,0.0012824225,0.60967326],"genre_scores_gemma":[0.08101593,0.15678847,0.010344179,0.0022501978,0.00060115557,0.00010154663,0.0005778123,0.00024062015,0.7480801],"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","domain_scores_codex":[0.9999621,0.0000028960003,0.0000014623599,0.000007513617,0.000020075693,0.000005982402],"domain_scores_gemma":[0.9999789,0.0000070317337,0.0000028542513,0.0000021599003,0.0000046893606,0.000004394547],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009887344,0.00039020006,0.00023177877,0.00038223853,0.00016200301,0.00071416993,0.00031729665,0.00041356872,0.018542085],"category_scores_gemma":[0.0000736775,0.00011690475,0.00017100578,0.00034148496,0.00017654774,0.00043950093,0.00028041704,0.0009622959,0.006832683],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012042538,0.00012741878,0.00018678654,0.00051349186,0.000014194306,0.00016058974,0.00006580076,0.0010231774,0.14844978,0.027597485,0.062348936,0.7593918],"study_design_scores_gemma":[0.000020239484,0.00012906136,0.00084268884,0.00015652746,0.000018702385,0.0004511466,0.000042320677,0.00065695704,0.044307884,0.0082003735,0.945163,0.00001116285],"about_ca_topic_score_codex":0.00062955153,"about_ca_topic_score_gemma":0.001956162,"teacher_disagreement_score":0.018542085,"about_ca_system_score_codex":0.00039210008,"about_ca_system_score_gemma":0.0002011825,"threshold_uncertainty_score":0.06202942},"labels":[],"label_agreement":null},{"id":"W3136339002","doi":"10.1007/s00204-021-03014-2","title":"Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells","year":2021,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University; University of Ottawa; Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"Histone deacetylase; Biomarker; Transcriptome; Histone deacetylase inhibitor; Histone; Computational biology; Biology; Cancer research; Gene expression; Biochemistry; Gene","score_opus":0.014896085351167007,"score_gpt":0.2854462766304169,"score_spread":0.2705501912792499,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3136339002","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7506247,0.006282778,0.22241889,0.00061132293,0.0003754424,0.0010620273,0.008655165,0.0013984976,0.008571077],"genre_scores_gemma":[0.7182153,0.0059858602,0.2414159,0.00075383345,0.00009918082,0.0022445272,0.012233021,0.00026594536,0.018786576],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996505,0.000030061408,0.000021766664,0.000095867355,0.00015833706,0.00004342993],"domain_scores_gemma":[0.99981254,0.000026939344,0.000033693777,0.00001991016,0.000082954015,0.000023961558],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00053433113,0.00067503983,0.0004190267,0.0005862363,0.000295435,0.00050233194,0.0004149867,0.00060558866,0.0013094891],"category_scores_gemma":[0.00039093578,0.0002834547,0.00045200423,0.0004989756,0.00035288694,0.0003128114,0.0002730552,0.0008168813,0.000899887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003517595,0.000018286795,0.000526766,0.00003609925,0.0000066192065,0.000020376052,0.00002252137,0.00008939799,0.996897,0.000088388064,0.000060572886,0.0021987762],"study_design_scores_gemma":[0.000010560854,0.0002208368,0.003799691,0.000007651589,0.00003685179,0.00012093359,0.000048907834,0.0016392795,0.9906262,0.0000887839,0.0033920838,0.000008282134],"about_ca_topic_score_codex":0.0013394941,"about_ca_topic_score_gemma":0.003480246,"teacher_disagreement_score":0.0013394941,"about_ca_system_score_codex":0.00039813147,"about_ca_system_score_gemma":0.0005344941,"threshold_uncertainty_score":0.0043806434},"labels":[],"label_agreement":null},{"id":"W3137511353","doi":"10.26434/chemrxiv.14195207.v1","title":"Strategy for Lead Identification for Understudied Kinases","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Novartis Pharma; Genentech; National Institutes of Health; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Gillings School of Public Health; North Carolina Biotechnology Center; Pfizer","keywords":"Kinase; Function (biology); Protein-Serine-Threonine Kinases; Pyrimidine; Computational biology; Cancer research; Cell biology; Chemistry; Biology; Biochemistry; Protein kinase A","score_opus":0.0784729463957375,"score_gpt":0.36205447597229357,"score_spread":0.2835815295765561,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3137511353","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.15483564,0.017980114,0.77008325,0.0037890056,0.0018808884,0.002900847,0.0032309033,0.0038011791,0.0414981],"genre_scores_gemma":[0.5648366,0.02298715,0.35366657,0.0034172647,0.0003388717,0.0024892257,0.0033407803,0.0009638484,0.04795968],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9993543,0.00010562795,0.000048473587,0.00015952342,0.00022857342,0.00010342679],"domain_scores_gemma":[0.99964035,0.00007333163,0.00004745956,0.00011291512,0.00007826864,0.000047725036],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010708944,0.0007736621,0.0008851843,0.0006568196,0.0005791735,0.0010570312,0.0008897315,0.0008301582,0.006886728],"category_scores_gemma":[0.0009255163,0.00044547755,0.0005358209,0.00058134814,0.00055809336,0.0009086668,0.0013257059,0.0025674747,0.004536713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00090499327,0.00040933638,0.00043431556,0.0012695272,0.00013183914,0.00096278114,0.00040504866,0.004100817,0.82653975,0.034159835,0.011598908,0.11908288],"study_design_scores_gemma":[0.0002897142,0.0013633375,0.00028146472,0.00009681184,0.00011325555,0.0011536829,0.000102823775,0.006565702,0.8117867,0.010998068,0.16716097,0.0000874617],"about_ca_topic_score_codex":0.0003124948,"about_ca_topic_score_gemma":0.0009350005,"teacher_disagreement_score":0.006886728,"about_ca_system_score_codex":0.00058619777,"about_ca_system_score_gemma":0.0009783491,"threshold_uncertainty_score":0.023038387},"labels":[],"label_agreement":null},{"id":"W3159206137","doi":"10.71781/26777","title":"Rôle de la protéine kinase B (Akt) dans la phosphorylation des histones désacétylases 5 (HDAC5) et l’expression de l’early growth response protein-1 (Egr-1) induites par l'angiotensine II dans les cellules musculaires lisses vasculaires","year":2020,"lang":"fr","type":"dissertation","venue":"Papyrus : Institutional Repository (Université de Montréal)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Molecular biology; Protein kinase B; Phosphorylation; Chemistry; Kinase; Protein kinase A; Biology; Cell biology","score_opus":0.00482206082440124,"score_gpt":0.19722288878748945,"score_spread":0.19240082796308822,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3159206137","genre_codex":"empirical","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9526373,0.034084786,0.0039827237,0.000734216,0.00033881541,0.00003786966,0.0006467034,0.000085814274,0.007451778],"genre_scores_gemma":[0.9804494,0.007211252,0.0014519198,0.00015920485,0.00003317786,0.000029530145,0.00053436373,0.000012539532,0.010118678],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979085,0.000033602424,0.000013358029,0.000051886065,0.000042747284,0.00006749352],"domain_scores_gemma":[0.9999207,0.000008282168,0.000021401089,0.0000071457243,0.000014497836,0.000027799379],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022938485,0.0002921294,0.00018642582,0.0002450924,0.0003418367,0.0005999034,0.00017751259,0.00036149408,0.0028568683],"category_scores_gemma":[0.000100457226,0.00022902974,0.00048484653,0.00017498927,0.00036032783,0.00039661318,0.00021829388,0.0006003158,0.00064211735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010923039,0.00013949565,0.0024058998,0.00032177966,0.000066199886,0.00015558717,0.000067913476,0.000295917,0.9849318,0.0010925812,0.00033046483,0.009099995],"study_design_scores_gemma":[0.00026114285,0.00100039,0.10641562,0.000067210465,0.0002416757,0.0008686683,0.0003538643,0.003518127,0.85840946,0.00063401007,0.028197838,0.00003200143],"about_ca_topic_score_codex":0.0027804042,"about_ca_topic_score_gemma":0.0031148603,"teacher_disagreement_score":0.0028568683,"about_ca_system_score_codex":0.00057523174,"about_ca_system_score_gemma":0.00058197044,"threshold_uncertainty_score":0.009557188},"labels":[],"label_agreement":null},{"id":"W3159784829","doi":"10.1016/j.dib.2021.107097","title":"A transcriptomic dataset used to derive biomarkers of chemically induced histone deacetylase inhibition (HDACi) in human TK6 cells","year":2021,"lang":"en","type":"article","venue":"Data in Brief","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Health Canada; Carleton University","funders":"Health Canada","keywords":"Transcriptome; Biology; Gene; Histone deacetylase; Biomarker; Toxicogenomics; Computational biology; Gene expression; Histone; Genetics","score_opus":0.043975529958808844,"score_gpt":0.34767494888448497,"score_spread":0.30369941892567615,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3159784829","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.36537004,0.0043850127,0.014505454,0.0003441148,0.00015045555,0.00076708733,0.60981977,0.0010104678,0.0036477065],"genre_scores_gemma":[0.19379105,0.0019053649,0.030164292,0.00037644393,0.000044193206,0.0017549013,0.7704384,0.00009199944,0.0014333273],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99946076,0.00005257919,0.00006549149,0.00021064958,0.00015090167,0.000059484137],"domain_scores_gemma":[0.99959296,0.000111883965,0.000069593014,0.000058688875,0.00013262118,0.00003430894],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041503477,0.000908658,0.0011964092,0.001160979,0.0006034824,0.0006642922,0.0005531259,0.0010415392,0.0016447784],"category_scores_gemma":[0.00081144285,0.00018055388,0.0009534395,0.0018695402,0.00029651631,0.00025304005,0.0004903376,0.0008386093,0.0011052223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002035454,0.0006808405,0.047809076,0.0043414035,0.00050089357,0.0010794362,0.00019356637,0.014206867,0.84154856,0.00085489335,0.020607727,0.06614129],"study_design_scores_gemma":[0.00049823057,0.0030402958,0.31169653,0.00044351426,0.0012464919,0.0028173379,0.00064941216,0.053838197,0.46342582,0.002238173,0.15983275,0.00027321815],"about_ca_topic_score_codex":0.00323303,"about_ca_topic_score_gemma":0.005143082,"teacher_disagreement_score":0.00323303,"about_ca_system_score_codex":0.0007171083,"about_ca_system_score_gemma":0.001237503,"threshold_uncertainty_score":0.0064284205},"labels":[],"label_agreement":null},{"id":"W3161786639","doi":"10.3390/cancers13102407","title":"Histone Acetyltransferases and Stem Cell Identity","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University of Calgary","funders":"Alberta Children's Hospital Research Institute","keywords":"Stem cell; Biology; Histone; Cell biology; Induced pluripotent stem cell; Epigenetics; Cellular differentiation; Epigenetic regulation of neurogenesis; Gene knockdown; Gene; Genetics; Embryonic stem cell; Histone methyltransferase","score_opus":0.034656964356748754,"score_gpt":0.36178589679220585,"score_spread":0.3271289324354571,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3161786639","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009755326,0.9977672,0.00012434012,0.0002839732,0.00024430832,0.0000028883323,0.000019067686,0.000006625521,0.0014540952],"genre_scores_gemma":[0.0007735484,0.9974745,0.00013799082,0.0001990514,0.00014180565,0.000004923624,0.000038441314,0.0000013293576,0.0012284165],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99988174,0.000016785516,0.000016199147,0.000026091231,0.000044104072,0.00001502288],"domain_scores_gemma":[0.9998566,0.000053245738,0.000018604671,0.000006290887,0.000045540495,0.000019713629],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041327122,0.0007159133,0.00079726806,0.0014506577,0.00023999283,0.00079176837,0.000770382,0.000987321,0.0039034788],"category_scores_gemma":[0.00042536686,0.00024832005,0.00028756823,0.0014812618,0.00051647256,0.0009786945,0.00060216925,0.0014932061,0.0030007903],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000079429716,0.000036857487,0.00019690733,0.006903353,0.00006000143,0.00019231168,0.00004077679,0.00036168515,0.0029255915,0.008850249,0.037806604,0.94254637],"study_design_scores_gemma":[0.0000070284977,0.00003979713,0.0005536449,0.00084590167,0.00003129805,0.0006473777,0.000020756544,0.0000417938,0.00054189825,0.0021926963,0.9950695,0.000008395173],"about_ca_topic_score_codex":0.0008692419,"about_ca_topic_score_gemma":0.0015832847,"teacher_disagreement_score":0.0039034788,"about_ca_system_score_codex":0.0008259742,"about_ca_system_score_gemma":0.00082491117,"threshold_uncertainty_score":0.013058424},"labels":[],"label_agreement":null},{"id":"W3165611947","doi":"10.1096/fasebj.25.1_supplement.945.14","title":"Valproic acid suppresses interleukin‐1β‐induced microsomal prostaglandin E2 Synthase‐1 expression in chondrocytes","year":2011,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Chromatin immunoprecipitation; Molecular biology; Prostaglandin E2; Chemistry; Western blot; Messenger RNA; Transcription (linguistics); Histone deacetylase; Transcription factor; Promoter; Histone deacetylase inhibitor; Blot; Gene expression; Histone; Biology; Biochemistry; Gene; Endocrinology","score_opus":0.026679499195515596,"score_gpt":0.2690241775425191,"score_spread":0.24234467834700352,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3165611947","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9923735,0.005256137,0.00096439326,0.00008864649,0.00006636701,0.000021124937,0.0003861845,0.000079851525,0.0007637212],"genre_scores_gemma":[0.99432546,0.001964485,0.00091997377,0.00006730341,0.000027797525,0.00003644297,0.0005146315,0.000015151089,0.0021286858],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987197,0.000020661955,0.000021393762,0.000026294932,0.000030219684,0.000029469296],"domain_scores_gemma":[0.9999242,0.000010629625,0.000023956532,0.000009434079,0.000010651237,0.00002120936],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010872747,0.00040856548,0.0003539741,0.00020698909,0.000108262124,0.00021966186,0.00012708144,0.00017228712,0.000969933],"category_scores_gemma":[0.00009176566,0.00012761149,0.00026219233,0.00012478894,0.00025821684,0.00010590789,0.00014734898,0.00044172365,0.00025101585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046864722,0.00004130212,0.00013063458,0.00007392816,0.00000817242,0.00002662038,0.000012358477,0.000036086654,0.9980014,0.000017611637,0.000031466516,0.0011518529],"study_design_scores_gemma":[0.000088978224,0.0013034518,0.0063594966,0.000008865978,0.000029323835,0.00018248305,0.00004465061,0.00038132502,0.9893022,0.000028751725,0.0022655209,0.0000048891],"about_ca_topic_score_codex":0.0006852092,"about_ca_topic_score_gemma":0.00090336887,"teacher_disagreement_score":0.000969933,"about_ca_system_score_codex":0.00018631085,"about_ca_system_score_gemma":0.0002592786,"threshold_uncertainty_score":0.0032448173},"labels":[],"label_agreement":null},{"id":"W3168174363","doi":"10.1101/2021.06.01.445760","title":"Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"HDAC6; Acetylation; Cancer research; Histone deacetylase; Lymphoma; Biology; Histone deacetylase inhibitor; B cell; Histone; Chemistry; Gene; Biochemistry; Antibody; Immunology","score_opus":0.008986655396674115,"score_gpt":0.24028466303636556,"score_spread":0.23129800763969144,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3168174363","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9824989,0.0066270586,0.0064611114,0.00026274353,0.000060420123,0.000040974413,0.00035246005,0.0003175797,0.0033787426],"genre_scores_gemma":[0.9914424,0.001749126,0.0028218185,0.00006488594,0.0000120544055,0.000026309966,0.00040488236,0.000025793312,0.003452794],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999267,0.000012038793,0.0000048680013,0.00001498675,0.000024598025,0.000016844417],"domain_scores_gemma":[0.99996865,0.000003476254,0.0000113035985,0.000003164776,0.000003049497,0.000010284273],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009164314,0.0002823203,0.00017970405,0.00018761719,0.000082025945,0.0002398318,0.00025135258,0.00018250263,0.0011317725],"category_scores_gemma":[0.00004295502,0.00012064274,0.00016798606,0.00012829377,0.00012294204,0.00012197577,0.00017658596,0.0005100627,0.0004889001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008116327,0.000025295016,0.00008466691,0.000021443742,0.0000055178702,0.000025390555,0.0000023510872,0.00009293823,0.9981627,0.00008672335,0.000051400995,0.0013605031],"study_design_scores_gemma":[0.000031809497,0.00023559625,0.0015005766,0.0000032570376,0.000016472895,0.00016926338,0.000005021262,0.0013478833,0.9925613,0.000054564185,0.0040722447,0.0000020222903],"about_ca_topic_score_codex":0.00020440028,"about_ca_topic_score_gemma":0.0005124555,"teacher_disagreement_score":0.0011317725,"about_ca_system_score_codex":0.00026624958,"about_ca_system_score_gemma":0.00010112877,"threshold_uncertainty_score":0.0037861466},"labels":[],"label_agreement":null},{"id":"W3170654500","doi":"10.1016/j.bmc.2021.116251","title":"Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"Chemistry; Histone deacetylase; Downregulation and upregulation; HDAC3; Phenotypic screening; HDAC1; Drug discovery; Acetylation; Histone deacetylase 2; Small molecule; Histone; Histone deacetylase inhibitor; Isozyme; Biochemistry; Pharmacology; Enzyme; Biology; Gene; Phenotype","score_opus":0.013026009036404494,"score_gpt":0.31205705577935705,"score_spread":0.29903104674295256,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3170654500","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.658847,0.22320649,0.057219822,0.0030006976,0.0011670045,0.000827237,0.0029071183,0.00096477976,0.051859774],"genre_scores_gemma":[0.8341877,0.1136468,0.022370873,0.0011779354,0.00027418733,0.0002873867,0.0024700738,0.000054169297,0.025530916],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999949,0.0000048176294,0.00000292475,0.0000113811175,0.000016306958,0.000015513579],"domain_scores_gemma":[0.9999676,0.0000033499357,0.0000069726498,0.0000029513192,0.000008301765,0.000010917034],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015949697,0.00037526913,0.00045240493,0.00041324223,0.00017053194,0.00050268613,0.00042332165,0.0002765671,0.0026362638],"category_scores_gemma":[0.00010668982,0.00017513816,0.00029021397,0.00030630644,0.00014736332,0.0003088706,0.00023320923,0.0006691078,0.00072729425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007263754,0.0005654704,0.0012121062,0.0010858962,0.00014806468,0.0007777513,0.00008198685,0.0019168422,0.80007493,0.011941163,0.0053789685,0.17609043],"study_design_scores_gemma":[0.0008526136,0.003149859,0.006694721,0.00015906642,0.00036482298,0.0022963327,0.00006384858,0.0064555695,0.6871126,0.0032675168,0.28951797,0.000065039116],"about_ca_topic_score_codex":0.00040408337,"about_ca_topic_score_gemma":0.0014221389,"teacher_disagreement_score":0.0026362638,"about_ca_system_score_codex":0.00047584728,"about_ca_system_score_gemma":0.000329532,"threshold_uncertainty_score":0.008819163},"labels":[],"label_agreement":null},{"id":"W3171699140","doi":"10.1021/acs.jmedchem.1c00420","title":"Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"H2020 European Research Council; Canada Research Chairs; Ontario Ministry of Research, Innovation and Science; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Syöpäsäätiö; Academy of Finland; Horizon 2020 Framework Programme; Natural Sciences and Engineering Research Council of Canada; Syöpäjärjestöt; Austrian Science Fund; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Prolymphocytic leukemia; Cancer research; Chemistry; HDAC6; Romidepsin; Bendamustine; Combination therapy; Bortezomib; Leukemia; Epigenetics; Potency; Pharmacology; Histone deacetylase; Medicine; Immunology; Histone; Multiple myeloma; In vitro; Chronic lymphocytic leukemia; Biochemistry","score_opus":0.009695318014349048,"score_gpt":0.2603993099789439,"score_spread":0.25070399196459486,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3171699140","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9692972,0.015380037,0.006980799,0.0002765054,0.00008321412,0.00026169044,0.0011529436,0.00026688495,0.0063007674],"genre_scores_gemma":[0.98836285,0.006006743,0.0031711175,0.00007753753,0.000014786461,0.000062905085,0.00074247655,0.00001549018,0.0015461294],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999954,0.0000056037866,0.0000037618886,0.000011168527,0.000008713101,0.000016707541],"domain_scores_gemma":[0.99997747,0.000003060114,0.0000060211696,0.000002866714,0.0000032727664,0.000007302574],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013343248,0.0003431493,0.0002458617,0.00022773628,0.000116142066,0.00028240538,0.0001892345,0.00016557208,0.0010156938],"category_scores_gemma":[0.00006582113,0.00012183233,0.00020970528,0.00020101623,0.00010406279,0.00015055836,0.00011919669,0.00039946396,0.00035927328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000450034,0.00017973347,0.00050000154,0.00010791842,0.000018090479,0.000117723794,0.000016149623,0.00053131947,0.9735329,0.0002611251,0.0002594043,0.024025556],"study_design_scores_gemma":[0.00034620706,0.003674131,0.0043821433,0.000018296703,0.00010486606,0.0009390201,0.00002389341,0.0019552468,0.97514194,0.00011139835,0.013290338,0.000012574096],"about_ca_topic_score_codex":0.0005549679,"about_ca_topic_score_gemma":0.0017342633,"teacher_disagreement_score":0.0010156938,"about_ca_system_score_codex":0.00028204644,"about_ca_system_score_gemma":0.00024097512,"threshold_uncertainty_score":0.0033978224},"labels":[],"label_agreement":null},{"id":"W3173646756","doi":"10.1096/fasebj.2019.33.1_supplement.476.29","title":"Ang‐II‐Induced Phosphorylation and Nuclear Export of Histone Deacetylase 5 is Mediated by an AKT‐Dependent Pathway in Vascular Smooth Muscle Cells","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Histone deacetylase 5; Phosphorylation; Mef2; Protein kinase B; HDAC4; Angiotensin II; Cell biology; Histone deacetylase; PI3K/AKT/mTOR pathway; Histone H3; Transcription factor; Signal transduction; Histone; Vascular smooth muscle; Cancer research; Biology; Endocrinology; Chemistry; Internal medicine; Medicine; Biochemistry; Gene","score_opus":0.009570872360474835,"score_gpt":0.25262914969881406,"score_spread":0.24305827733833923,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3173646756","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9858084,0.0071285525,0.0022608552,0.0003593802,0.000188196,0.000048814123,0.00081783364,0.000111110225,0.0032769924],"genre_scores_gemma":[0.9869561,0.004347927,0.0021547633,0.00018380387,0.000046732224,0.0000770809,0.0016851905,0.0000118771595,0.0045364895],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990153,0.000012791073,0.000009660348,0.000016532147,0.000022897846,0.000036612717],"domain_scores_gemma":[0.99996483,0.0000034883521,0.000009320646,0.0000044972126,0.000003557602,0.000014317842],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013267923,0.00030785048,0.000247705,0.0002036748,0.00021690133,0.00023013866,0.00019011562,0.00015585822,0.0015407028],"category_scores_gemma":[0.00005342939,0.00021459475,0.0004135782,0.00022779012,0.00017330768,0.00017764703,0.00016692505,0.0007427467,0.00039388225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003745171,0.00011144884,0.00030409766,0.000109320434,0.000019906756,0.00007534788,0.000019497724,0.000069979156,0.9971717,0.00018702744,0.00012953309,0.0014276836],"study_design_scores_gemma":[0.0002443752,0.001104625,0.052933183,0.000026467333,0.00008137994,0.00051069376,0.000078230616,0.002760304,0.9353038,0.00021127301,0.0067288354,0.000016804515],"about_ca_topic_score_codex":0.0012209651,"about_ca_topic_score_gemma":0.0022410164,"teacher_disagreement_score":0.0015407028,"about_ca_system_score_codex":0.00029181986,"about_ca_system_score_gemma":0.00037669012,"threshold_uncertainty_score":0.005154133},"labels":[],"label_agreement":null},{"id":"W31751639","doi":"10.1007/978-3-642-21631-2_1","title":"K-Acetylation and Its Enzymes: Overview and New Developments","year":2011,"lang":"en","type":"review","venue":"Handbook of experimental pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Acetylation; Lysine; Acetyltransferases; Sirtuin; Histone; Biochemistry; Histone Acetyltransferases; Enzyme; Posttranslational modification; Computational biology; Biology; Chemistry; Amino acid; Gene","score_opus":0.13151460421042577,"score_gpt":0.4211807294440643,"score_spread":0.28966612523363855,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W31751639","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000074396456,0.99834716,0.0004962817,0.00012488147,0.0002200375,0.0000041805583,0.000024078501,0.000016525886,0.0006925046],"genre_scores_gemma":[0.00050524814,0.9974663,0.00063513406,0.00013129627,0.0002611813,0.0000090112135,0.00005135847,0.000002989359,0.00093741843],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997998,0.000022167174,0.00002775909,0.000047662455,0.00007544703,0.00002723711],"domain_scores_gemma":[0.99981385,0.0000675341,0.000029385805,0.000011739742,0.000051256255,0.00002618705],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006177259,0.0017308309,0.0023767971,0.0021298584,0.00030418465,0.0013659904,0.0016299667,0.0013760888,0.0032323692],"category_scores_gemma":[0.00039425603,0.00077585405,0.0006274278,0.0035200317,0.0008968056,0.002105093,0.0008299379,0.0028481907,0.005245859],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023236008,0.00012421457,0.00014361207,0.013282687,0.0000842035,0.00019945408,0.000038874176,0.000533258,0.007792547,0.005252202,0.038262066,0.9340545],"study_design_scores_gemma":[0.00003311028,0.00009876291,0.00045356693,0.0008204198,0.00007541203,0.0010360721,0.000028049322,0.00012727764,0.0020274578,0.00288789,0.99238116,0.00003085102],"about_ca_topic_score_codex":0.0010973655,"about_ca_topic_score_gemma":0.0022964692,"teacher_disagreement_score":0.0032323692,"about_ca_system_score_codex":0.0009628622,"about_ca_system_score_gemma":0.001358694,"threshold_uncertainty_score":0.010813296},"labels":[],"label_agreement":null},{"id":"W3177349605","doi":"10.1096/fasebj.21.6.lb93-d","title":"PKA promotes MEF2/HDAC repression of the c‐Jun promoter in vascular smooth muscle cells","year":2007,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Mef2; HDAC4; Myocardin; Vascular smooth muscle; Platelet-derived growth factor receptor; Cell biology; Biology; Signal transduction; JUNB; Psychological repression; Molecular biology; Growth factor; Cancer research; Transcription factor; Histone deacetylase; Histone; Serum response factor; Enhancer; Gene expression; Endocrinology; Gene; Biochemistry; Receptor","score_opus":0.010973729127381223,"score_gpt":0.2637385674139412,"score_spread":0.25276483828656,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3177349605","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9893807,0.0023623083,0.0026925178,0.00026138348,0.00013586442,0.000033483637,0.0012208583,0.00014208043,0.003770766],"genre_scores_gemma":[0.98604405,0.001191631,0.0030811038,0.0001299737,0.000052800267,0.000056792793,0.0018136821,0.000046810484,0.0075831367],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998641,0.000020936312,0.000011876276,0.00002684896,0.000032110867,0.000044080378],"domain_scores_gemma":[0.99989355,0.000019940126,0.000018784538,0.000017473483,0.00001463565,0.000035497316],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015598549,0.0003195958,0.00019941476,0.00022896836,0.00016951191,0.00025443255,0.00017228811,0.00017931157,0.0018617105],"category_scores_gemma":[0.0001082485,0.00017037608,0.00024668378,0.00011228687,0.00019911115,0.00012080321,0.00025297518,0.00057130016,0.00079656026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000069976326,0.000021146774,0.000044777928,0.000019944866,0.0000021190976,0.000013196502,0.00000477833,0.000026423488,0.9993,0.000039955776,0.000057075278,0.00040063754],"study_design_scores_gemma":[0.00004331618,0.00017157517,0.0057282452,0.000009324053,0.000009981293,0.00008895535,0.000023971204,0.0014968301,0.9890676,0.000047484267,0.0033084776,0.0000041907133],"about_ca_topic_score_codex":0.0016567176,"about_ca_topic_score_gemma":0.0027345717,"teacher_disagreement_score":0.0018617105,"about_ca_system_score_codex":0.0004027585,"about_ca_system_score_gemma":0.00031563215,"threshold_uncertainty_score":0.0062280893},"labels":[],"label_agreement":null},{"id":"W3183250534","doi":"10.1007/s00280-021-04339-6","title":"Repurposing proscillaridin A in combination with decitabine against embryonal rhabdomyosarcoma RD cells","year":2021,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Cancer Research Society","keywords":"Decitabine; Cancer research; Azacitidine; Clonogenic assay; Rhabdomyosarcoma; Cell cycle; Demethylating agent; Biology; Paclitaxel; Chromatin immunoprecipitation; Chromatin; Epigenetics; DNA methylation; Cancer; Cell; Sarcoma; Gene expression; Medicine; Pathology; Gene; Biochemistry","score_opus":0.00957550685859864,"score_gpt":0.29500060313102366,"score_spread":0.285425096272425,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3183250534","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930098,0.001822817,0.0005670333,0.00018426178,0.000117880074,0.000077682336,0.00051022874,0.00009302946,0.0036173032],"genre_scores_gemma":[0.9947472,0.0011571584,0.0006165934,0.000053301163,0.00001348675,0.000050218623,0.0005791072,0.00000757044,0.0027753229],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999088,0.000018576513,0.000009788116,0.000011603894,0.00001725297,0.00003391082],"domain_scores_gemma":[0.99995375,0.000009555714,0.00000624377,0.000007787538,0.000004842965,0.000017774943],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015516173,0.00039790227,0.00040917232,0.0003664407,0.00019814585,0.0002580593,0.0003475873,0.00027178408,0.0026562838],"category_scores_gemma":[0.000109526445,0.000117056115,0.00027806728,0.00022949469,0.00018348568,0.00018014322,0.00018460299,0.00074823364,0.00041522156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0035527612,0.0006800503,0.00039609167,0.00021336722,0.00005690875,0.00024757028,0.00006709455,0.0010623811,0.97439903,0.00032583304,0.000946078,0.01805287],"study_design_scores_gemma":[0.00062080455,0.0052684485,0.0054774345,0.000018968041,0.00010024137,0.0003344191,0.000112267044,0.0014851324,0.9779854,0.000080426384,0.008503339,0.000013109916],"about_ca_topic_score_codex":0.0020279845,"about_ca_topic_score_gemma":0.004578178,"teacher_disagreement_score":0.0026562838,"about_ca_system_score_codex":0.00031890156,"about_ca_system_score_gemma":0.00053699815,"threshold_uncertainty_score":0.0088861585},"labels":[],"label_agreement":null},{"id":"W3184918505","doi":"10.3389/fendo.2021.679655","title":"Histone Deacetylases in the Pathogenesis of Diabetic Cardiomyopathy","year":2021,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; Impact","funders":"","keywords":"Diabetic cardiomyopathy; Epigenetics; Pathogenesis; Histone; Medicine; Diabetes mellitus; Bioinformatics; Inflammation; Cardiomyopathy; Fibrosis; Oxidative stress; Chromatin; Internal medicine; Biology; Endocrinology; Heart failure; Genetics; Gene","score_opus":0.024588144053953608,"score_gpt":0.3298974075358193,"score_spread":0.3053092634818657,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3184918505","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00013026164,0.99879956,0.00008430714,0.00026259202,0.00017998547,0.0000016883512,0.000011720329,0.0000049791306,0.0005249142],"genre_scores_gemma":[0.0008820067,0.99819785,0.00010196108,0.00013142638,0.00017476846,0.0000024091678,0.000025077328,7.965865e-7,0.00048380083],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999242,0.000014241872,0.000011669905,0.000013628261,0.00002436921,0.000011891157],"domain_scores_gemma":[0.99991167,0.000027832048,0.000014001815,0.0000026647222,0.000028775596,0.000015133133],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031104672,0.00055556465,0.00071114727,0.0011552271,0.00020276218,0.0005862483,0.00048572916,0.0007021547,0.0023620056],"category_scores_gemma":[0.00029171945,0.00014275438,0.00029937792,0.0011051655,0.00025663548,0.0006686603,0.00048091318,0.0011043987,0.0013312058],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017123879,0.00007570054,0.00040458533,0.011534041,0.000115083305,0.00042172713,0.000085575026,0.00038558082,0.0048656478,0.00526312,0.039633423,0.9370442],"study_design_scores_gemma":[0.000025049096,0.00013008984,0.001763295,0.0025123442,0.00013377436,0.002019735,0.00007659499,0.00012561404,0.0011259352,0.0036765365,0.9883868,0.000024244751],"about_ca_topic_score_codex":0.0007322797,"about_ca_topic_score_gemma":0.0012266635,"teacher_disagreement_score":0.0023620056,"about_ca_system_score_codex":0.00046569225,"about_ca_system_score_gemma":0.0007339897,"threshold_uncertainty_score":0.007901728},"labels":[],"label_agreement":null},{"id":"W3186586328","doi":"10.1007/s13402-021-00626-9","title":"Histone deacetylase (HDAC) 9: versatile biological functions and emerging roles in human cancer","year":2021,"lang":"en","type":"review","venue":"Cellular Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Foundation for the National Institutes of Health","keywords":"Histone deacetylase; Histone; HDAC10; HDAC4; Biology; Histone deacetylase 5; HDAC11; Cell biology; Cancer research; Genetics; Gene","score_opus":0.054790922037980846,"score_gpt":0.4046402146564482,"score_spread":0.34984929261846737,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3186586328","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000105521445,0.99850464,0.00010513,0.00027693997,0.00020268049,0.0000028605598,0.000017548977,0.000007609907,0.0007770341],"genre_scores_gemma":[0.0007558612,0.99825627,0.00012152291,0.00016391637,0.00016299449,0.0000035451208,0.000032207,0.0000011130883,0.0005025098],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99989605,0.000016711832,0.000012366715,0.000020839092,0.000037855898,0.00001607549],"domain_scores_gemma":[0.99986947,0.000042978463,0.000018693729,0.000004672884,0.000041571504,0.000022539094],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035164185,0.0007011203,0.0007919098,0.0012857168,0.0002125444,0.0006281356,0.0005676854,0.00069970614,0.002614792],"category_scores_gemma":[0.00036433764,0.00018642492,0.00030931263,0.0016216317,0.00038242203,0.0007578651,0.000494718,0.0014052251,0.0018380536],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000100700396,0.00003200943,0.00022056595,0.007646095,0.00006623475,0.00016560592,0.000035231802,0.00028148093,0.0025200706,0.0029277538,0.03341261,0.95259166],"study_design_scores_gemma":[0.000021766384,0.00008077596,0.0008570901,0.0010166143,0.00006825867,0.0012686374,0.000033099335,0.00007207091,0.000641107,0.0016879431,0.9942392,0.00001341927],"about_ca_topic_score_codex":0.00094036077,"about_ca_topic_score_gemma":0.0017740923,"teacher_disagreement_score":0.002614792,"about_ca_system_score_codex":0.0006705659,"about_ca_system_score_gemma":0.0008198223,"threshold_uncertainty_score":0.008747339},"labels":[],"label_agreement":null},{"id":"W3190987809","doi":"10.1021/acs.jmedchem.1c00440","title":"Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Novartis Pharma; Office of Strategic Coordination; Genentech; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Pfizer; ALS Association; Wellcome Trust; North Carolina Biotechnology Center; Ministero dello Sviluppo Economico; U.S. Department of Defense","keywords":"Kinome; Kinase; Pyrimidine; Chemistry; Lead compound; Drug discovery; Biochemistry; Small molecule; In vitro","score_opus":0.02317298410696653,"score_gpt":0.31469386973615004,"score_spread":0.2915208856291835,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3190987809","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92969805,0.015636321,0.032552533,0.00063369295,0.00016881533,0.0012736351,0.0027020979,0.00052045425,0.016814468],"genre_scores_gemma":[0.9662053,0.007694214,0.016429167,0.0003082391,0.000030790987,0.00021743389,0.0018098361,0.000038044174,0.0072670756],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987066,0.000018837602,0.00001009763,0.00003427314,0.000033465923,0.000032634027],"domain_scores_gemma":[0.9999026,0.000013288188,0.000023472936,0.000010582695,0.00002246844,0.000027643006],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026371435,0.0005946853,0.00056449766,0.0005883258,0.00023605455,0.00043159735,0.00040981077,0.00031185764,0.0026628813],"category_scores_gemma":[0.0002443786,0.00019999364,0.00025458858,0.0004163742,0.00021997665,0.0002877967,0.00046136876,0.00078771356,0.00059347897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005527917,0.00050529256,0.0012321941,0.00055588386,0.000069438545,0.00071735436,0.00012234741,0.0044237114,0.93847746,0.002564667,0.0011253294,0.049653582],"study_design_scores_gemma":[0.000565112,0.007881105,0.004288617,0.0001422784,0.00023449466,0.0018144667,0.000108253334,0.0064362884,0.9403412,0.0013558206,0.03676876,0.0000635985],"about_ca_topic_score_codex":0.0005537933,"about_ca_topic_score_gemma":0.0033514313,"teacher_disagreement_score":0.0026628813,"about_ca_system_score_codex":0.0004173066,"about_ca_system_score_gemma":0.0005238391,"threshold_uncertainty_score":0.008908153},"labels":[],"label_agreement":null},{"id":"W3198872327","doi":"10.1126/scitranslmed.aaz6804","title":"A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Terry Fox Foundation; Li Ka Shing Foundation","keywords":"Blockade; Immune checkpoint; Immune system; Reprogramming; Immunity; Medicine; Hepatocellular carcinoma; Cancer research; Immunology; Immunotherapy; Biology; Receptor; Internal medicine; Cell","score_opus":0.013919303287682868,"score_gpt":0.28190069501060994,"score_spread":0.26798139172292706,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3198872327","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9963373,0.0010852946,0.0006951519,0.0000681194,0.000039478244,0.00002128295,0.00012637979,0.00007875236,0.0015482996],"genre_scores_gemma":[0.9977818,0.0005177255,0.00029549902,0.000022491135,0.000011413376,0.000017044165,0.00014740309,0.0000074768272,0.0011990309],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993384,0.000011106825,0.000006502905,0.000007766157,0.000013257009,0.000027515096],"domain_scores_gemma":[0.9999664,0.00000460346,0.00000671349,0.000005097369,0.0000038869603,0.000013295235],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117608026,0.00027177786,0.0002866381,0.00016108896,0.00008573265,0.00014151548,0.00015344516,0.00010814367,0.0012203134],"category_scores_gemma":[0.00006183307,0.000081253434,0.00016488518,0.00011312926,0.00013061789,0.00012440732,0.000100006575,0.00050305546,0.0002741134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007540411,0.0002852124,0.00037931482,0.000059645037,0.000016633061,0.000032424425,0.000012616497,0.00020970381,0.9885107,0.000088461995,0.00019057293,0.009460641],"study_design_scores_gemma":[0.0001292185,0.0034916543,0.00577041,0.000005776422,0.00004458557,0.00017919677,0.000021752845,0.00096629956,0.98685545,0.00003591548,0.0024946472,0.000005122006],"about_ca_topic_score_codex":0.00048488603,"about_ca_topic_score_gemma":0.0017504625,"teacher_disagreement_score":0.0012203134,"about_ca_system_score_codex":0.00019209759,"about_ca_system_score_gemma":0.000197481,"threshold_uncertainty_score":0.0040823817},"labels":[],"label_agreement":null},{"id":"W3199543258","doi":"10.1021/acs.analchem.1c01359","title":"Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes—a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC–MS","year":2021,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"FP7 Ideas: European Research Council; Horizon 2020; Haukeland Universitetssjukehus; Universitair Medisch Centrum Groningen; Universitetet i Bergen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Tiroler Wissenschaftsförderung; Rijksuniversiteit Groningen; Universitetet i Tromsø; European Respiratory Society; European Commission; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Universität Innsbruck; Carl von Ossietzky Universität Oldenburg","keywords":"Acetylation; Acetic anhydride; Chemistry; Lysine; Histone; Biochemistry; Amino acid; Catalysis; DNA; Gene","score_opus":0.02245648797300133,"score_gpt":0.3091427383668417,"score_spread":0.2866862503938404,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3199543258","genre_codex":"methods","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":"methods","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.32941228,0.016786128,0.63811827,0.0010414763,0.0008365141,0.00061885087,0.002367217,0.002062317,0.008756926],"genre_scores_gemma":[0.55462664,0.014139794,0.41051492,0.00218687,0.00043858256,0.0014744046,0.00451885,0.00062584964,0.011474011],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99895704,0.00014577771,0.000053887466,0.00034553313,0.00040368302,0.0000939712],"domain_scores_gemma":[0.9991079,0.00022179706,0.00027023852,0.00012978644,0.0001931385,0.000077119104],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011011395,0.0011463156,0.0007051458,0.0008469792,0.00048425578,0.000783088,0.0009725278,0.0011671137,0.0012876679],"category_scores_gemma":[0.0011298351,0.00055162783,0.00053821155,0.0006998402,0.0006092678,0.0009290707,0.0007302987,0.0018239853,0.00092559523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000726558,0.000025533862,0.00018592949,0.00009429415,0.000041373907,0.000052791263,0.000023508877,0.0000926285,0.9943277,0.00045358544,0.00021581756,0.0044140904],"study_design_scores_gemma":[0.000010427576,0.00015842615,0.00079969416,0.0000071052536,0.000019219986,0.00020703119,0.0000074730833,0.0012161147,0.993486,0.00020766298,0.0038648155,0.000016118462],"about_ca_topic_score_codex":0.00040218452,"about_ca_topic_score_gemma":0.001017046,"teacher_disagreement_score":0.0012876679,"about_ca_system_score_codex":0.00068152917,"about_ca_system_score_gemma":0.0005123844,"threshold_uncertainty_score":0.0058234334},"labels":[],"label_agreement":null},{"id":"W3204756219","doi":"10.1139/cjpp-2021-0012","title":"Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Science and Engineering Research Board","keywords":"Medicine; Cachexia; Cancer; Sodium butyrate; Internal medicine; Sirius Red; Pathology; Endocrinology; Cancer research; Biology; Immunohistochemistry","score_opus":0.013094428043029101,"score_gpt":0.3043797794582993,"score_spread":0.2912853514152702,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3204756219","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97130764,0.021955527,0.0017551678,0.00028264028,0.0001900589,0.0002531523,0.00040359792,0.000077449426,0.0037748339],"genre_scores_gemma":[0.9829396,0.011964842,0.0014737948,0.00014816529,0.00006552698,0.00014729319,0.00047166558,0.00001117155,0.0027779788],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992836,0.0000121230105,0.000005916815,0.000014659516,0.00001629818,0.000022541713],"domain_scores_gemma":[0.9999449,0.0000069865832,0.00001326563,0.000004953653,0.000009243122,0.00002063357],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188574,0.0002893498,0.00051740784,0.00021185406,0.00017232474,0.00019521962,0.00020503133,0.00017639832,0.0012989052],"category_scores_gemma":[0.00009436979,0.0001053968,0.000314779,0.00022906576,0.00016775381,0.00018250037,0.00010751419,0.0007312044,0.00015346594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0044286367,0.0017685689,0.0013467342,0.000673024,0.00013294422,0.00018376137,0.000053768024,0.0002736898,0.95808476,0.0002744546,0.0006096435,0.03217006],"study_design_scores_gemma":[0.0017301097,0.052354142,0.026382757,0.000069794696,0.0005928972,0.0007912416,0.00016509356,0.0019066258,0.90096533,0.00017761497,0.014836983,0.000027381828],"about_ca_topic_score_codex":0.0005419385,"about_ca_topic_score_gemma":0.0024609517,"teacher_disagreement_score":0.0012989052,"about_ca_system_score_codex":0.00020715219,"about_ca_system_score_gemma":0.00035614992,"threshold_uncertainty_score":0.004345298},"labels":[],"label_agreement":null},{"id":"W3210893762","doi":"10.3390/ijms222111701","title":"Histone Modification in NSCLC: Molecular Mechanisms and Therapeutic Targets","year":2021,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Epigenetics; Vorinostat; Epigenomics; Lung cancer; Cancer research; Histone; Panobinostat; Cancer epigenetics; Histone deacetylase; Targeted therapy; Medicine; Cancer; Epigenetic therapy; Oncology; DNA methylation; Biology; Bioinformatics; Internal medicine; Genetics; Gene; Gene expression; Histone methyltransferase","score_opus":0.040450108723912574,"score_gpt":0.39360830135105795,"score_spread":0.3531581926271454,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3210893762","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.010529925,0.97959226,0.0009968006,0.0038918597,0.00045961555,0.000037171478,0.00018976364,0.000049122253,0.004253497],"genre_scores_gemma":[0.15254334,0.8376438,0.0015813257,0.0022829017,0.0012170464,0.0001149868,0.00062306446,0.00001572558,0.003977777],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998715,0.000024246365,0.0000115772755,0.00002360798,0.000040861716,0.000028221928],"domain_scores_gemma":[0.9998989,0.000018573015,0.000022004486,0.00000647109,0.00003336537,0.00002059075],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037527166,0.00030889828,0.000549722,0.00039737427,0.00020000717,0.00061810337,0.00038693278,0.00055761746,0.0015558122],"category_scores_gemma":[0.00029339577,0.00013547491,0.00039115254,0.0003591178,0.00034832754,0.0004977799,0.0003676521,0.0011885122,0.0006757208],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089966063,0.0004017165,0.008166902,0.009279827,0.00037500486,0.0013155966,0.0002380659,0.0017857428,0.099461734,0.015594148,0.037469905,0.8250117],"study_design_scores_gemma":[0.00040109496,0.003190573,0.0387767,0.0030841774,0.0007977539,0.0076454775,0.00046339692,0.003872949,0.048972573,0.022218768,0.8704444,0.0001321071],"about_ca_topic_score_codex":0.00066770794,"about_ca_topic_score_gemma":0.001211299,"teacher_disagreement_score":0.0015558122,"about_ca_system_score_codex":0.0006689044,"about_ca_system_score_gemma":0.0005090624,"threshold_uncertainty_score":0.0052046776},"labels":[],"label_agreement":null},{"id":"W3214159644","doi":"10.1182/blood-2021-148708","title":"Inhibiting Mitochondrial Complex II Exposes a Novel Metabolic Vulnerability in Acute Myeloid Leukemia","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo; Princess Margaret Cancer Centre; University Health Network; University of Guelph","funders":"","keywords":"Myeloid leukemia; Leukemia; Clonogenic assay; Cancer research; Haematopoiesis; Biology; Oxidative phosphorylation; Small hairpin RNA; Cell growth; Cell culture; Gene knockdown; Chemistry; Cell biology; In vitro; Stem cell; Biochemistry; Immunology; Genetics","score_opus":0.022348291674684943,"score_gpt":0.2876432056239809,"score_spread":0.26529491394929594,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3214159644","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9892014,0.003593927,0.004148472,0.00021393273,0.000045922003,0.00007120588,0.0005577287,0.0002056304,0.0019618666],"genre_scores_gemma":[0.9955146,0.0014397348,0.0012004932,0.00006302699,0.000004091043,0.000023086537,0.0005110686,0.00000912604,0.0012349617],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995565,0.0000048704173,0.000004394813,0.0000094198485,0.000012956011,0.000012687329],"domain_scores_gemma":[0.9999747,0.0000036441409,0.000008408428,0.0000023313848,0.0000040041496,0.000006754326],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006059105,0.00028545698,0.00028582898,0.00015387987,0.00012396007,0.0002568455,0.00020133467,0.00022497316,0.001450383],"category_scores_gemma":[0.00006518917,0.00008461716,0.00023625517,0.00014136753,0.00012722172,0.0001464352,0.00017400627,0.00036402312,0.00029819802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021393424,0.000059462716,0.00044486765,0.00011787459,0.000019033992,0.00012985425,0.000010456409,0.00074526534,0.99330646,0.00030380272,0.00013363325,0.0045152544],"study_design_scores_gemma":[0.00013706197,0.0018111179,0.0054409322,0.000022057313,0.00007992604,0.00081727223,0.00004134252,0.004618313,0.9758075,0.0002710271,0.010935859,0.000017693219],"about_ca_topic_score_codex":0.0005729806,"about_ca_topic_score_gemma":0.0011447726,"teacher_disagreement_score":0.001450383,"about_ca_system_score_codex":0.00038160282,"about_ca_system_score_gemma":0.00018196885,"threshold_uncertainty_score":0.0048520565},"labels":[],"label_agreement":null},{"id":"W3214558115","doi":"10.1016/j.bmcl.2021.128441","title":"Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; McGill University Health Centre; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Antiandrogen; Vorinostat; Enzalutamide; Chemistry; Histone deacetylase; Cancer research; Histone deacetylase inhibitor; Androgen receptor; HeLa; Prostate cancer; Biochemistry; Cell; Histone; Androgen; Biology; Cancer; Gene; Genetics","score_opus":0.006017437053869335,"score_gpt":0.2248244756253679,"score_spread":0.21880703857149855,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3214558115","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9646609,0.0043498543,0.01300944,0.00033533262,0.00020016027,0.000085445536,0.0005985834,0.00048961304,0.01627058],"genre_scores_gemma":[0.9874691,0.0008913138,0.0053760046,0.0001193135,0.000013559924,0.000048042388,0.00030490354,0.000027502889,0.0057503353],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999149,0.000007535665,0.0000038539097,0.000023243867,0.000020305666,0.000030252902],"domain_scores_gemma":[0.9999765,0.0000032439764,0.0000061795254,0.0000022636023,0.0000035364574,0.0000081942735],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008281568,0.00038765586,0.00022079892,0.00018694717,0.00016908284,0.00036804925,0.00045019796,0.00037157437,0.0016065195],"category_scores_gemma":[0.00006270009,0.00017412826,0.0001904313,0.00016671,0.00016688382,0.000246629,0.0002042931,0.0003596636,0.0004967757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011352074,0.00001425976,0.000051139756,0.000032400927,0.000011672914,0.000045190973,0.000011758813,0.00012607324,0.99602425,0.0005269678,0.00013786432,0.0029048966],"study_design_scores_gemma":[0.00001620955,0.000118256336,0.00029531383,0.0000016500154,0.000016714575,0.00007357654,0.00000927452,0.00051761244,0.9948198,0.000042365114,0.0040826406,0.000006583114],"about_ca_topic_score_codex":0.00055078854,"about_ca_topic_score_gemma":0.0011021822,"teacher_disagreement_score":0.0016065195,"about_ca_system_score_codex":0.00048656095,"about_ca_system_score_gemma":0.000119945085,"threshold_uncertainty_score":0.005374372},"labels":[],"label_agreement":null},{"id":"W3216754191","doi":"10.1182/blood-2021-148143","title":"Sirtuin 3 Inhibition Targets AML Stem Cells through Perturbation of Fatty Acid Oxidation","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Sirtuin; SIRT3; Stem cell; Cancer research; Biology; Oxidative phosphorylation; Myeloid; NAD+ kinase; Cancer cell; Cancer stem cell; Viability assay; Cancer; Biochemistry; Cell; Cell biology; Genetics","score_opus":0.013166223429150454,"score_gpt":0.24940648566894374,"score_spread":0.2362402622397933,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3216754191","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9754073,0.0067776996,0.006162973,0.0008493656,0.00034731865,0.0001448577,0.0017159195,0.00084739714,0.0077472585],"genre_scores_gemma":[0.99292785,0.0016651902,0.0017083556,0.00032314484,0.000019372499,0.000050226783,0.00092491735,0.000036196594,0.0023447725],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998529,0.000013208726,0.000011509929,0.000023837121,0.000058354548,0.00004002816],"domain_scores_gemma":[0.9999331,0.000009933722,0.000017922852,0.0000073454435,0.000013004169,0.000018736328],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015847474,0.00029593002,0.00036406558,0.0003303215,0.00018599383,0.0004150894,0.00024885737,0.00030182107,0.0026484004],"category_scores_gemma":[0.00015724289,0.00013370426,0.0005090541,0.00021664855,0.00030172584,0.00017616787,0.00023013889,0.00090233184,0.0007341289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00061843486,0.00013089449,0.000787581,0.00013902121,0.000036638692,0.00007447865,0.000039740436,0.00028119428,0.9865654,0.00033958862,0.0008982346,0.010088741],"study_design_scores_gemma":[0.00015745807,0.00093121885,0.00537431,0.00001879593,0.000091206166,0.00025936516,0.00007869267,0.0017205992,0.97721726,0.00026947088,0.013871609,0.000009987062],"about_ca_topic_score_codex":0.0009704313,"about_ca_topic_score_gemma":0.0020692989,"teacher_disagreement_score":0.0026484004,"about_ca_system_score_codex":0.00042906118,"about_ca_system_score_gemma":0.00037213945,"threshold_uncertainty_score":0.008859813},"labels":[],"label_agreement":null},{"id":"W3217067747","doi":"10.1093/femsml/uqab013","title":"Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics","year":2021,"lang":"en","type":"article","venue":"microLife","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Agence Nationale de la Recherche; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Histone; Epigenetics; Biology; Acetylation; Chromatin; Histone-modifying enzymes; Histone Acetyltransferases; Histone deacetylase; Cell biology; Chromatin remodeling; Genetics; Computational biology; Gene","score_opus":0.011630433905186505,"score_gpt":0.2941315699344416,"score_spread":0.2825011360292551,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3217067747","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0019253587,0.97088337,0.005041778,0.0053741634,0.002507219,0.000040052902,0.00017304861,0.0001832685,0.013871768],"genre_scores_gemma":[0.022373533,0.9465074,0.004051529,0.0030478034,0.0021560194,0.00009050103,0.00030826285,0.000046635236,0.021418424],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99967575,0.00005918884,0.000018053623,0.00006647194,0.00013277719,0.000047867576],"domain_scores_gemma":[0.99978477,0.000052976004,0.000031578285,0.000012778021,0.00006819069,0.000049708386],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006403667,0.00080492994,0.0007884248,0.0010818328,0.00039357672,0.0014778564,0.0007083683,0.001319683,0.0061540557],"category_scores_gemma":[0.000466109,0.00026022366,0.00038706613,0.0010265005,0.00090172247,0.00153372,0.0009341714,0.002477141,0.0036365185],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036145156,0.00019590236,0.00059660955,0.006272195,0.000112355105,0.0005102644,0.00022146522,0.00079562695,0.057171706,0.054366004,0.06713271,0.8122636],"study_design_scores_gemma":[0.000028285629,0.00021270095,0.00047286937,0.0003699597,0.000041610187,0.00072311866,0.000059289705,0.00023043639,0.010571337,0.008076776,0.97919136,0.000022233025],"about_ca_topic_score_codex":0.0005183682,"about_ca_topic_score_gemma":0.001182935,"teacher_disagreement_score":0.0061540557,"about_ca_system_score_codex":0.0011985074,"about_ca_system_score_gemma":0.00087540847,"threshold_uncertainty_score":0.020587385},"labels":[],"label_agreement":null},{"id":"W32653155","doi":"10.1016/j.jcjd.2020.03.013","title":"HDAC function during chick neural tube development","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Molecular biology; Biology","score_opus":0.0058763632696739255,"score_gpt":0.2111465606441004,"score_spread":0.20527019737442648,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W32653155","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9622656,0.012009344,0.006905889,0.00089008454,0.0002393326,0.00004675662,0.0012723745,0.00021988276,0.016150724],"genre_scores_gemma":[0.98272693,0.0021686153,0.0023682087,0.00016116555,0.000017535469,0.000030891857,0.0005936897,0.00006715485,0.011865829],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985003,0.000026506776,0.000012557483,0.00003988557,0.000028143568,0.000042927775],"domain_scores_gemma":[0.99978834,0.000036749716,0.000043061867,0.000020652778,0.000029706895,0.00008160788],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021314833,0.00028767792,0.00024491627,0.00028952968,0.00036426052,0.0006725233,0.00029440253,0.0005311379,0.0033880312],"category_scores_gemma":[0.00038788654,0.00027391722,0.00039734054,0.0000804292,0.00036916812,0.00041753444,0.00036814788,0.0010676297,0.0010265298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00092739187,0.00002920224,0.006267473,0.00013268506,0.000027721973,0.000655976,0.00017474403,0.0003195355,0.9708346,0.0019582612,0.0007324424,0.017940043],"study_design_scores_gemma":[0.00008995368,0.000537252,0.19357285,0.00014505562,0.00011703944,0.0015845594,0.00062403467,0.0027174687,0.77020913,0.00085494027,0.029509097,0.00003861561],"about_ca_topic_score_codex":0.0049216086,"about_ca_topic_score_gemma":0.010406212,"teacher_disagreement_score":0.0049216086,"about_ca_system_score_codex":0.001008029,"about_ca_system_score_gemma":0.00054585875,"threshold_uncertainty_score":0.011334062},"labels":[],"label_agreement":null},{"id":"W4205272218","doi":"10.1038/s42255-021-00515-3","title":"Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity","year":2022,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; American Diabetes Association; American Heart Association","keywords":"Leptin; HDAC6; Endocrinology; Internal medicine; Adipose tissue; Histone deacetylase; Adipokine; Obesity; Sirtuin; Melanocortin; Medicine; Chemistry; Acetylation; Hormone; Histone; Biochemistry","score_opus":0.005871267498082921,"score_gpt":0.27644090639892394,"score_spread":0.270569638900841,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4205272218","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9866188,0.0031810512,0.002991352,0.0012086661,0.0006500812,0.000046702757,0.0015079314,0.0009665356,0.002828913],"genre_scores_gemma":[0.98590964,0.0026591758,0.0017723445,0.0005054472,0.00012522539,0.000059806298,0.0016757128,0.0002039743,0.007088668],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997696,0.00002581591,0.000023995928,0.000039467785,0.000060135575,0.00008098665],"domain_scores_gemma":[0.9996878,0.000026109466,0.000082254875,0.000035295492,0.000020420297,0.00014818691],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021374383,0.000747843,0.0007757402,0.0006447896,0.0002675805,0.00059454935,0.0007782232,0.000609945,0.0051855217],"category_scores_gemma":[0.00024096131,0.00043450808,0.0006400802,0.00032524104,0.0006306349,0.00037058722,0.00034743454,0.0024899347,0.0010058407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.008249964,0.0009263838,0.00037464986,0.00012335449,0.00015661579,0.00012985726,0.000021781525,0.00030506897,0.9790893,0.0003772046,0.00084097317,0.009404748],"study_design_scores_gemma":[0.0021878385,0.0069425474,0.011465936,0.00003479833,0.00032146342,0.0005293694,0.00018307178,0.0017227172,0.96261245,0.0006172818,0.01332645,0.000056036126],"about_ca_topic_score_codex":0.0011711083,"about_ca_topic_score_gemma":0.0021044342,"teacher_disagreement_score":0.0051855217,"about_ca_system_score_codex":0.00039068394,"about_ca_system_score_gemma":0.0004890984,"threshold_uncertainty_score":0.017347276},"labels":[],"label_agreement":null},{"id":"W4205899547","doi":"10.1093/hmg/ddab370","title":"The anti-inflammatory mechanism of SAHA in acute pancreatitis through HDAC5/SLIT2/Akt/β-catenin axis","year":2022,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pancreas Centre (Canada)","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Chromatin immunoprecipitation; Acinar cell; Histone deacetylase 5; Acute pancreatitis; Gene silencing; Apoptosis; Myeloperoxidase; Inflammation; Downregulation and upregulation","score_opus":0.010181311379471878,"score_gpt":0.27083404728284083,"score_spread":0.26065273590336896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4205899547","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9552555,0.032364678,0.0048789443,0.00070693047,0.00025043124,0.0000945678,0.001140719,0.0002458075,0.0050623976],"genre_scores_gemma":[0.9857305,0.008882431,0.00172059,0.00018475324,0.000054791366,0.00006809148,0.000623412,0.000014966362,0.0027204677],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999828,0.000027913313,0.000020829944,0.0000324017,0.00003597914,0.000054853273],"domain_scores_gemma":[0.99993706,0.000003495375,0.000022423448,0.0000048540237,0.000011618528,0.000020653093],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017337826,0.00038655818,0.00043600512,0.00035088006,0.0002248814,0.00040997198,0.00019154159,0.00026092824,0.0018454092],"category_scores_gemma":[0.00008904874,0.00016885196,0.00058588746,0.00020607028,0.0002869531,0.0003470193,0.00025794664,0.00069069286,0.00029967635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013522345,0.00014861088,0.002101361,0.0006462594,0.000089525376,0.0003140927,0.000063420914,0.0001565028,0.9811497,0.00052225165,0.00039934332,0.013056786],"study_design_scores_gemma":[0.000337547,0.0022450928,0.047876384,0.00009390037,0.00039588317,0.0010484385,0.0002465805,0.0014976696,0.92824125,0.0005355982,0.017450785,0.000030924894],"about_ca_topic_score_codex":0.00046129202,"about_ca_topic_score_gemma":0.0010201003,"teacher_disagreement_score":0.0018454092,"about_ca_system_score_codex":0.00031593078,"about_ca_system_score_gemma":0.0003972881,"threshold_uncertainty_score":0.006173551},"labels":[],"label_agreement":null},{"id":"W4206623829","doi":"10.21203/rs.3.rs-620068/v1","title":"Synergic Effects of Anticancer Peptide CIGB-552 and Cisplatin in Lung Cancer Models","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Cisplatin; Lung cancer; Peptide; Cancer research; Chemistry; Pharmacology; Medicine; Oncology; Internal medicine; Chemotherapy; Biochemistry","score_opus":0.02338497823096157,"score_gpt":0.38707884205056786,"score_spread":0.3636938638196063,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4206623829","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9905634,0.0031825483,0.0015377321,0.0002929676,0.00026158214,0.00012438447,0.00085367745,0.0001219711,0.0030616662],"genre_scores_gemma":[0.9937044,0.0017464667,0.0010763812,0.00006466631,0.000048814694,0.00011897222,0.00053815584,0.000020701638,0.0026814423],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99969065,0.00007042245,0.000020516884,0.00005967705,0.00006761496,0.000091238566],"domain_scores_gemma":[0.99986136,0.00003043341,0.00001993973,0.000015968208,0.000012223497,0.000060060906],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025016195,0.0005604097,0.00072342454,0.00054743985,0.0002371394,0.0003340174,0.00043277707,0.00058775157,0.0018552594],"category_scores_gemma":[0.00014847319,0.00020897592,0.00039062754,0.00034806645,0.00043058745,0.0003686573,0.00033407757,0.0012248807,0.00040756824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.006169147,0.0009887363,0.00033131326,0.00023611043,0.000058055575,0.00021427462,0.000050642142,0.0011484558,0.9834283,0.00040781673,0.0006350879,0.0063320436],"study_design_scores_gemma":[0.00047862827,0.007227757,0.0019506373,0.000016984744,0.00013637522,0.00020863528,0.00007206255,0.0014874261,0.9841053,0.00017706714,0.00412043,0.00001874454],"about_ca_topic_score_codex":0.0011251036,"about_ca_topic_score_gemma":0.0014306967,"teacher_disagreement_score":0.0018552594,"about_ca_system_score_codex":0.00035895113,"about_ca_system_score_gemma":0.00053388544,"threshold_uncertainty_score":0.006206453},"labels":[],"label_agreement":null},{"id":"W4206826307","doi":"10.22541/au.159000338.83671779","title":"Valproic Acid in Prevention and Treatment of COVID-19","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Valproic Acid; Coronavirus disease 2019 (COVID-19); Coronavirus; Drug; Medicine; Inflammation; Pharmacology; Mechanism (biology); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Drug repositioning; Bioinformatics; Immunology; Internal medicine; Biology; Epilepsy; Psychiatry; Disease","score_opus":0.049099009922125326,"score_gpt":0.3651960536159105,"score_spread":0.31609704369378516,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4206826307","genre_codex":"review","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.2537421,0.7198384,0.0023831425,0.0058873026,0.001665957,0.000120448756,0.00075900863,0.0002513067,0.015352343],"genre_scores_gemma":[0.778379,0.20350742,0.004152413,0.0017438451,0.0008332406,0.00007887951,0.00089274393,0.00005599271,0.010356411],"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","domain_scores_codex":[0.9998735,0.00004699515,0.00001544468,0.000017355618,0.000027187138,0.000019383484],"domain_scores_gemma":[0.99993205,0.000011624943,0.00001815703,0.000006583841,0.000010580302,0.000021065838],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024127925,0.00025448352,0.0004072888,0.00031830225,0.000114315495,0.0003391776,0.00023643498,0.00041592016,0.0017414868],"category_scores_gemma":[0.00023221473,0.00006273155,0.00033480485,0.00021680581,0.00020239614,0.0001933112,0.00020925645,0.0008170833,0.0005207818],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.029119048,0.0019935672,0.004638672,0.0037549422,0.00089858274,0.0024535472,0.00015446836,0.0011510188,0.10063136,0.004415903,0.015015952,0.8357729],"study_design_scores_gemma":[0.013681284,0.031305782,0.08674809,0.0022798823,0.0016511255,0.015653592,0.00038781494,0.0030338597,0.20842035,0.011312082,0.6254148,0.00011128231],"about_ca_topic_score_codex":0.00043157907,"about_ca_topic_score_gemma":0.00070437544,"teacher_disagreement_score":0.0017414868,"about_ca_system_score_codex":0.00027440707,"about_ca_system_score_gemma":0.00039272633,"threshold_uncertainty_score":0.005825877},"labels":[],"label_agreement":null},{"id":"W4210447019","doi":"10.1021/acs.jmedchem.1c01585","title":"Discovery of HDAC6-Selective Inhibitor NN-390 with <i>in Vitro</i> Efficacy in Group 3 Medulloblastoma","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Institute for Cancer Research; Canada Foundation for Innovation; Leukemia and Lymphoma Society of Canada; Canadian Cancer Society; Natural Sciences and Engineering Research Council of Canada; McMaster University; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Government of Ontario","keywords":"HDAC6; Chemistry; Medulloblastoma; In vitro; Cancer research; Population; Pharmacology; Histone deacetylase; Biochemistry; Biology; Medicine; Histone","score_opus":0.004676145289358553,"score_gpt":0.24184102414146522,"score_spread":0.23716487885210666,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4210447019","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9533265,0.017980559,0.0073946435,0.00071947917,0.00021204859,0.0003517937,0.0022440152,0.0003966447,0.0173743],"genre_scores_gemma":[0.98175436,0.008797367,0.0031692276,0.0003284301,0.00003413226,0.000076041106,0.0016751101,0.000034504217,0.0041307914],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994504,0.000007772786,0.000003577076,0.000011052911,0.000015767051,0.00001677571],"domain_scores_gemma":[0.99996674,0.0000034998486,0.000007988186,0.000002918878,0.000007046632,0.000011800628],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015457443,0.00039260782,0.00039413277,0.00016457417,0.00013796674,0.00024116518,0.00028483875,0.00024711457,0.001946241],"category_scores_gemma":[0.00010507337,0.0001458954,0.0003033425,0.00015918854,0.00010535058,0.00018446593,0.00017923208,0.0005953338,0.0005548957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00077261165,0.00034130746,0.0004735346,0.00025499662,0.00004141063,0.00021622097,0.000049789523,0.00085974205,0.9675878,0.000419418,0.0016158127,0.027367394],"study_design_scores_gemma":[0.0006500364,0.007762271,0.0055209114,0.0000486609,0.00016650304,0.0014854344,0.000050735736,0.002260273,0.95094335,0.00023140921,0.030848516,0.000031955627],"about_ca_topic_score_codex":0.0016639259,"about_ca_topic_score_gemma":0.0053994916,"teacher_disagreement_score":0.001946241,"about_ca_system_score_codex":0.0004052327,"about_ca_system_score_gemma":0.000295129,"threshold_uncertainty_score":0.006510794},"labels":[],"label_agreement":null},{"id":"W4212790569","doi":"10.1101/lm.053536.121","title":"Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice","year":2022,"lang":"en","type":"article","venue":"Learning & Memory","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"PCAF; Histone acetyltransferase; Histone Acetyltransferases; Acetyltransferase; Histone; Acetylation; P300-CBP Transcription Factors; Cancer research; Neuroscience; Psychology; Medicine; Chemistry; Biochemistry; Gene","score_opus":0.01452137538726555,"score_gpt":0.27394682938144527,"score_spread":0.2594254539941797,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4212790569","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9922316,0.0016368049,0.0030274673,0.00024552294,0.00006645004,0.000065013824,0.0011733057,0.00031574094,0.0012379583],"genre_scores_gemma":[0.98489386,0.0018702942,0.004525167,0.00015069339,0.000029521263,0.00014248842,0.0009635289,0.000075656426,0.0073488723],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999841,0.000013052842,0.000015831567,0.000044556906,0.000033118573,0.00005243977],"domain_scores_gemma":[0.99980646,0.000010001739,0.00008166931,0.00001808447,0.000019353829,0.00006456293],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027579715,0.00089601806,0.0004935817,0.0010051688,0.00032243773,0.0004356254,0.00046467388,0.00059547205,0.0013722294],"category_scores_gemma":[0.00010701556,0.00026235162,0.0005806421,0.00028086733,0.00054659287,0.00041062362,0.00024039613,0.0015684792,0.00040201528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004335948,0.00019478616,0.00025871012,0.000025738036,0.000010218658,0.00006644593,0.000027528664,0.000044372122,0.9962625,0.00012384243,0.00007091747,0.0024813374],"study_design_scores_gemma":[0.00009669356,0.0017736601,0.008446436,0.000014319161,0.000048513266,0.0002863652,0.00004908545,0.0005130253,0.9867426,0.00015608907,0.001859653,0.000013489928],"about_ca_topic_score_codex":0.002707711,"about_ca_topic_score_gemma":0.0052683284,"teacher_disagreement_score":0.002707711,"about_ca_system_score_codex":0.0005084542,"about_ca_system_score_gemma":0.00049878063,"threshold_uncertainty_score":0.0053839087},"labels":[],"label_agreement":null},{"id":"W4214582450","doi":"10.1002/jlcr.3968","title":"High‐yielding, automated radiosynthesis of [<sup>11</sup>C]martinostat using [<sup>11</sup>C]methyl triflate","year":2022,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fondation Brain Canada","keywords":"Radiosynthesis; Chemistry; Trifluoromethanesulfonate; Methyl iodide; Anhydrous; In vivo; Acylation; Yield (engineering); Iodide; Ethanol; Chemical synthesis; Chromatography; Nuclear chemistry; Radiochemistry; Medicinal chemistry; Organic chemistry; Catalysis; In vitro; Biochemistry","score_opus":0.026319553061377537,"score_gpt":0.32509783187239427,"score_spread":0.2987782788110167,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4214582450","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85853684,0.0016942509,0.12512024,0.0001732817,0.000079840094,0.00048265824,0.0012860316,0.00078743004,0.011839488],"genre_scores_gemma":[0.91678196,0.0018033067,0.070333876,0.00010984042,0.000025591897,0.0003180568,0.0018894348,0.00025557252,0.008482393],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985707,0.000027818614,0.0000077336035,0.000044623837,0.000034921322,0.000027766187],"domain_scores_gemma":[0.99989784,0.000025348558,0.00002820053,0.000021333477,0.00001697991,0.000010307129],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004272399,0.0005745964,0.00029988642,0.00025614534,0.0001881819,0.00020619783,0.00046130698,0.00041394087,0.0017180853],"category_scores_gemma":[0.00023147753,0.00025176656,0.00025981784,0.00017706142,0.00030737917,0.00024623825,0.00021096994,0.0005651391,0.0010662402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013031726,0.000017144417,0.00009617536,0.00006445957,0.000012062581,0.00007657107,0.00003998952,0.00050539436,0.99568343,0.00048015508,0.00017346899,0.0027207786],"study_design_scores_gemma":[0.00001879244,0.00022182886,0.00027482535,0.000004112684,0.000010388034,0.00013310942,0.000009196058,0.0004944948,0.99391645,0.00003660335,0.00486997,0.000010180817],"about_ca_topic_score_codex":0.0007634698,"about_ca_topic_score_gemma":0.0015369429,"teacher_disagreement_score":0.0017180853,"about_ca_system_score_codex":0.00036420306,"about_ca_system_score_gemma":0.0003669163,"threshold_uncertainty_score":0.0057475567},"labels":[],"label_agreement":null},{"id":"W4220803013","doi":"10.21203/rs.3.rs-1427931/v1","title":"Combination Treatment with Histone Deacetylase and Carbonic Anhydrase 9 Inhibitors Shows Therapeutic Potential in Experimental Diffuse Intrinsic Pontine Glioma","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Curing Kids Cancer; Cure Starts Now Foundation","keywords":"Panobinostat; Vorinostat; Histone deacetylase; Cancer research; Combination therapy; Glioma; Cell cycle; Histone deacetylase inhibitor; Cell growth; Histone; Carbonic anhydrase; Chemistry; Population; Biology; Apoptosis; Pharmacology; Biochemistry; Medicine; Enzyme","score_opus":0.022202219261285516,"score_gpt":0.3499680703341604,"score_spread":0.32776585107287487,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4220803013","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952306,0.0028809514,0.0007405103,0.00007991458,0.000029887651,0.00007024393,0.00015036477,0.00005767471,0.0007598342],"genre_scores_gemma":[0.99646556,0.0015430792,0.00096141285,0.00003732535,0.000014748918,0.00005171005,0.00029933173,0.0000076934475,0.0006192581],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988806,0.000017563974,0.000006990091,0.000023024742,0.0000336088,0.00003072641],"domain_scores_gemma":[0.9999542,0.0000062814174,0.00001105297,0.000006453132,0.0000048719294,0.000017093726],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015044384,0.00039778757,0.0005373624,0.00030465337,0.00012880283,0.0002078595,0.0002719702,0.000194623,0.0011432436],"category_scores_gemma":[0.000081792714,0.00010023562,0.00033173722,0.00023160514,0.00023745319,0.00017959303,0.00016630022,0.0005216738,0.00014617028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037125323,0.0009217477,0.001405417,0.00033632602,0.00009881113,0.00041293164,0.000035212,0.0003176103,0.97198266,0.00008724003,0.00026627557,0.020423215],"study_design_scores_gemma":[0.00079774176,0.032807477,0.017679617,0.000021562464,0.00031001295,0.0018735048,0.00008853097,0.0017140906,0.93936926,0.00007027114,0.005251135,0.000016788845],"about_ca_topic_score_codex":0.0007909664,"about_ca_topic_score_gemma":0.0020697156,"teacher_disagreement_score":0.0011432436,"about_ca_system_score_codex":0.0002752841,"about_ca_system_score_gemma":0.00028113366,"threshold_uncertainty_score":0.003824532},"labels":[],"label_agreement":null},{"id":"W4220816361","doi":"10.21203/rs.3.rs-1426447/v1","title":"A single amino acid at PNT domain of ERG mediates its leukemogenic activity through interaction with the NCoR-HDAC3 co-repressor complex","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Israel Science Foundation; Weizmann Institute of Science","keywords":"Repressor; HDAC3; Domain (mathematical analysis); Chemistry; Cancer research; Genetics; Cell biology; Biology; Biochemistry; Transcription factor; Gene; Mathematics","score_opus":0.08651385598067705,"score_gpt":0.4021879818272435,"score_spread":0.31567412584656646,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4220816361","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9698247,0.0017944082,0.019341933,0.00048845145,0.00019208166,0.00006536889,0.002634869,0.00043765243,0.0052205794],"genre_scores_gemma":[0.98521453,0.00045995147,0.0048433268,0.00018484311,0.000019531844,0.000033890556,0.0031607284,0.000113796355,0.0059693963],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998939,0.000016840637,0.000007747731,0.000027408663,0.00002365674,0.000030474102],"domain_scores_gemma":[0.9998759,0.000021893291,0.000025026588,0.000018682764,0.000011944637,0.000046608242],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010819565,0.00048222076,0.0003649345,0.00016805544,0.0002540607,0.00032972335,0.00040624032,0.0005183749,0.0044722063],"category_scores_gemma":[0.00020237184,0.0001251505,0.0006722096,0.00019305517,0.0003377728,0.00030110625,0.00035282286,0.0007892377,0.0030050972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027380922,0.000016011176,0.00023218215,0.000048407554,0.000009167389,0.00033146844,0.000010035631,0.00015132448,0.99724895,0.00023112637,0.00013320937,0.0013143645],"study_design_scores_gemma":[0.000041132105,0.00006595421,0.005728431,0.000011327467,0.000022283348,0.0009894419,0.00003214505,0.0012744508,0.98681915,0.000110227746,0.0048911152,0.000014432297],"about_ca_topic_score_codex":0.0017872526,"about_ca_topic_score_gemma":0.0011207248,"teacher_disagreement_score":0.0044722063,"about_ca_system_score_codex":0.0005152723,"about_ca_system_score_gemma":0.00036564632,"threshold_uncertainty_score":0.014961004},"labels":[],"label_agreement":null},{"id":"W4220817791","doi":"10.1016/j.neo.2022.100777","title":"Corrigendum to “Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo” [Neoplasia 10/3 (2008) 266-278]","year":2022,"lang":"en","type":"erratum","venue":"Neoplasia","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; In vivo; In vitro; Gene; Biology; Methylation; Cell biology; DNA; Cancer research; Chemistry; Genetics; Gene expression","score_opus":0.021238029280533754,"score_gpt":0.28942127441109583,"score_spread":0.2681832451305621,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4220817791","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00019751789,0.004258194,0.00065538596,0.031519588,0.95168376,0.00007152963,0.00083805283,0.0003975625,0.010378316],"genre_scores_gemma":[0.0075839646,0.020690747,0.004621907,0.07698061,0.30135164,0.00029900853,0.0043189144,0.0007372531,0.58341587],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99764365,0.00020573946,0.00027575862,0.0003752465,0.0011428394,0.0003567605],"domain_scores_gemma":[0.9948319,0.00073562603,0.00028685093,0.00048625856,0.0031645158,0.0004947556],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016925129,0.003904011,0.003936383,0.0057124197,0.0041771573,0.0027996795,0.004973007,0.008246172,0.092187874],"category_scores_gemma":[0.008442816,0.0018731386,0.0040121144,0.0034083934,0.0016838176,0.0020464805,0.0019755212,0.0068962383,0.05378999],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005199437,0.00001970798,0.00003943854,0.00020244409,0.000023769866,0.0002821914,0.000008614346,0.000066520966,0.0004308621,0.00043269593,0.99287593,0.0055658724],"study_design_scores_gemma":[0.000072274146,0.00007352285,0.002170753,0.00014784194,0.0001457446,0.00052324054,0.00003484845,0.0003561396,0.0020600243,0.0010035589,0.99335575,0.00005645936],"about_ca_topic_score_codex":0.025481464,"about_ca_topic_score_gemma":0.039719075,"teacher_disagreement_score":0.092187874,"about_ca_system_score_codex":0.004430832,"about_ca_system_score_gemma":0.0031905079,"threshold_uncertainty_score":0.3083992},"labels":[],"label_agreement":null},{"id":"W4220846385","doi":"10.1016/j.exphem.2022.03.003","title":"Epigenetic maintenance strategies after allogeneic stem cell transplantation in acute myeloid leukemia","year":2022,"lang":"en","type":"review","venue":"Experimental Hematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; Ontario Clinical Oncology Group; McMaster University Medical Centre; Discovery Centre; Juravinski Cancer Centre","funders":"Ontario Institute for Cancer Research","keywords":"Myeloid leukemia; Epigenetics; Immune system; Leukemia; Immunology; Stem cell; Transplantation; Minimal residual disease; Haematopoiesis; Hematopoietic stem cell transplantation; Myeloid; Medicine; Immunotherapy; Cancer research; Biology; Internal medicine","score_opus":0.020192995636697696,"score_gpt":0.32244204365456647,"score_spread":0.3022490480178688,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4220846385","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00010564706,0.9991091,0.0001437821,0.000106867315,0.0001456923,0.0000027234248,0.000008446136,0.0000035047528,0.0003741383],"genre_scores_gemma":[0.0011037341,0.99784195,0.0002115098,0.0001783003,0.00021771724,0.0000073369915,0.000034441204,0.0000014542248,0.0004035082],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99987817,0.000022282096,0.000016183247,0.000024207617,0.00004133601,0.000017710403],"domain_scores_gemma":[0.99985254,0.000072441806,0.000026426678,0.0000055290097,0.000028545619,0.00001454866],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006829229,0.00085895223,0.0012495897,0.0009550201,0.00017282878,0.00080360216,0.0009402627,0.0008754277,0.0013639065],"category_scores_gemma":[0.00051673135,0.00024051603,0.000380045,0.0010915955,0.000505398,0.0007155413,0.00052827917,0.0018055908,0.00077733345],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021463,0.00009176814,0.0001392529,0.0097803855,0.00010371476,0.00018105296,0.000030241496,0.0004950159,0.0043998347,0.00496567,0.020099709,0.95949864],"study_design_scores_gemma":[0.00009383612,0.00022256056,0.0011930182,0.0023438784,0.0002456614,0.001138307,0.0000415498,0.00021311925,0.0027022588,0.0034329377,0.9883454,0.000027477514],"about_ca_topic_score_codex":0.0006240856,"about_ca_topic_score_gemma":0.0015786364,"teacher_disagreement_score":0.0013639065,"about_ca_system_score_codex":0.00061483454,"about_ca_system_score_gemma":0.0005900304,"threshold_uncertainty_score":0.0045627356},"labels":[],"label_agreement":null},{"id":"W4221010528","doi":"10.1101/2022.03.16.484594","title":"Dual blockade of misfolded alpha-sarcoglycan degradation by bortezomib and givinostat combination","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Association Vaincre la Mucoviscidose; University of California, San Francisco; University of Toronto","keywords":"Proteasome; Protein degradation; Limb-girdle muscular dystrophy; Bortezomib; Biology; Proteasome inhibitor; Genetics; Mutation; Gene; Cell biology; Immunology","score_opus":0.009101143377226818,"score_gpt":0.234173832257797,"score_spread":0.2250726888805702,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4221010528","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930737,0.0017768781,0.0021699793,0.0001360735,0.000047474918,0.000062862026,0.00039112408,0.000111025554,0.0022308673],"genre_scores_gemma":[0.9952094,0.0006543678,0.0024152722,0.000033407512,0.000008880588,0.000028187858,0.0002828862,0.000011884288,0.0013556487],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999936,0.0000110160745,0.000005379584,0.000010571498,0.000021325786,0.000015673953],"domain_scores_gemma":[0.99997425,0.000004918,0.0000053479616,0.0000034467319,0.0000030525637,0.00000893605],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009454994,0.0002448091,0.00036638934,0.00020875069,0.00007603125,0.00020188598,0.00017504967,0.00016213422,0.0010479989],"category_scores_gemma":[0.00006776915,0.00006339033,0.00020173723,0.00014371068,0.00011868675,0.00008976036,0.00014125543,0.0003082731,0.00018391253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013066309,0.00023518356,0.00040136097,0.00009089983,0.00004194798,0.00012585432,0.000013480781,0.0015519089,0.9852247,0.00023409649,0.00028752242,0.010486471],"study_design_scores_gemma":[0.0002512594,0.002597382,0.0017448297,0.0000067848127,0.000054790595,0.00024789746,0.000012981146,0.0043847715,0.9873979,0.00008725554,0.0032065879,0.000007517498],"about_ca_topic_score_codex":0.0004006275,"about_ca_topic_score_gemma":0.0009682246,"teacher_disagreement_score":0.0010479989,"about_ca_system_score_codex":0.00019381246,"about_ca_system_score_gemma":0.000174779,"threshold_uncertainty_score":0.0035058856},"labels":[],"label_agreement":null},{"id":"W4224443226","doi":"10.1038/s41598-022-10740-9","title":"Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; Fondation Cancer","keywords":"Calcitriol receptor; Histone deacetylase; Agonist; Chemistry; Histone deacetylase inhibitor; Cancer research; Vorinostat; Triple-negative breast cancer; Pharmacology; Nuclear receptor; Cytotoxicity; Cancer cell; Biochemistry; Histone; Transcription factor; Receptor; Biology; Cancer; Breast cancer; In vitro; Gene; Genetics","score_opus":0.0077057950460434396,"score_gpt":0.26312469081616413,"score_spread":0.25541889577012067,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4224443226","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9903989,0.0026376399,0.003978342,0.00010869904,0.000021854032,0.00008552634,0.00022188289,0.0000853287,0.0024618802],"genre_scores_gemma":[0.99563843,0.00085898535,0.0019077916,0.000047933798,0.0000039050387,0.00006525334,0.00013254095,0.000007060991,0.0013380537],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993765,0.000011711248,0.0000035394914,0.000013215278,0.000017412005,0.000016475547],"domain_scores_gemma":[0.99998045,0.0000045650218,0.0000053328995,0.0000021165845,0.0000023006573,0.0000052534056],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013914231,0.00021073272,0.00017152166,0.000114183444,0.00010101766,0.00020555947,0.00022709338,0.00025092132,0.00069603726],"category_scores_gemma":[0.00006042729,0.00011585701,0.00017460376,0.00008147402,0.00012334423,0.00021046163,0.00013038654,0.00022445488,0.00021974459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010708827,0.000048392405,0.00009789268,0.00006483987,0.000013060225,0.00006779069,0.000025471692,0.00046958512,0.9950486,0.000623228,0.000085493506,0.0033485042],"study_design_scores_gemma":[0.000033379194,0.0006506595,0.00080035423,0.000003987926,0.000018568046,0.000160594,0.000016040873,0.002102924,0.9930703,0.00007562369,0.0030616336,0.0000059335325],"about_ca_topic_score_codex":0.00025381858,"about_ca_topic_score_gemma":0.0003844907,"teacher_disagreement_score":0.00069603726,"about_ca_system_score_codex":0.0002816345,"about_ca_system_score_gemma":0.000067214685,"threshold_uncertainty_score":0.0023284554},"labels":[],"label_agreement":null},{"id":"W4224857498","doi":"10.1158/2767-9764.crc-22-0037","title":"Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Toronto General Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"Government of Ontario","keywords":"Hydroxychloroquine; Repurposing; Itraconazole; Drug repositioning; Ovarian cancer; Cancer; Homeostasis; Medicine; Cancer research; Internal medicine; Pharmacology; Biology; Drug; Coronavirus disease 2019 (COVID-19); Dermatology; Disease; Antifungal","score_opus":0.05911338055807427,"score_gpt":0.4076690462993662,"score_spread":0.34855566574129193,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4224857498","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97648835,0.018166402,0.0018028744,0.0004130543,0.000039632094,0.00022587688,0.00036784267,0.00010613921,0.0023898764],"genre_scores_gemma":[0.99366236,0.003935769,0.0012509256,0.00014076248,0.000011174041,0.000047023168,0.00041641746,0.000009640418,0.0005258842],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998815,0.000032498745,0.000010522001,0.000017227741,0.000028686118,0.000029491113],"domain_scores_gemma":[0.9999162,0.000015384097,0.000017684915,0.000015414145,0.000016805521,0.000018569972],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028434925,0.00014376277,0.00040474685,0.00027488387,0.000120239165,0.00036367343,0.00019945452,0.00020072551,0.00069390854],"category_scores_gemma":[0.00016376658,0.00009659192,0.0003151745,0.0002446248,0.00014828007,0.00015386257,0.00021659011,0.00046829839,0.0001291643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010626281,0.00048783422,0.0035192114,0.00035260644,0.00008843698,0.00029591858,0.00006930875,0.0019518916,0.92066807,0.00023865691,0.00070265215,0.0705628],"study_design_scores_gemma":[0.001707367,0.019497067,0.05877606,0.00013839363,0.00034187746,0.0035909573,0.00027942422,0.0071446053,0.86712974,0.00074394693,0.040607374,0.000043184296],"about_ca_topic_score_codex":0.00072465517,"about_ca_topic_score_gemma":0.003566735,"teacher_disagreement_score":0.00072465517,"about_ca_system_score_codex":0.00036862513,"about_ca_system_score_gemma":0.00029960604,"threshold_uncertainty_score":0.0026745796},"labels":[],"label_agreement":null},{"id":"W4225393363","doi":"10.1096/fasebj.2022.36.s1.l7587","title":"A combinatorial chemical epigenetics screen identifies an off‐target modulation of drug transporter function","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Epigenetics; Cytotoxicity; Chemistry; Biology; Pharmacology; Molecular biology; Biochemistry; Cancer research; Cell biology; In vitro","score_opus":0.010912661735444503,"score_gpt":0.24983083741591328,"score_spread":0.23891817568046878,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4225393363","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.983709,0.0018678759,0.0069892374,0.00017438842,0.000039609356,0.00021881615,0.0011680244,0.00035328697,0.005479769],"genre_scores_gemma":[0.9903375,0.0012820557,0.004338284,0.00011895886,0.000010419717,0.000094769486,0.000900071,0.000030257837,0.0028878346],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997937,0.00002696791,0.000014127148,0.000045036042,0.00008445458,0.00003565492],"domain_scores_gemma":[0.99987364,0.000033184377,0.000033778713,0.000015496853,0.000023670973,0.00002025014],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022818164,0.0004212814,0.00042497576,0.00038671962,0.00013497719,0.00028572872,0.00029989355,0.0003515688,0.0022818],"category_scores_gemma":[0.00026431167,0.00020846885,0.00030510334,0.0002501796,0.0001647183,0.00018653338,0.00023278182,0.00038068736,0.00039373824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013605566,0.00007295082,0.0003805948,0.000056650704,0.000019227891,0.00008336944,0.000008224235,0.00041066157,0.9925477,0.0001261912,0.00009540449,0.0060629947],"study_design_scores_gemma":[0.000032721993,0.001247464,0.002645796,0.0000046721357,0.000044290977,0.00027195757,0.000012612892,0.0010808877,0.9921737,0.000037396145,0.0024403485,0.000008172498],"about_ca_topic_score_codex":0.00032178304,"about_ca_topic_score_gemma":0.0013399969,"teacher_disagreement_score":0.0022818,"about_ca_system_score_codex":0.00042326114,"about_ca_system_score_gemma":0.00023043442,"threshold_uncertainty_score":0.0076334476},"labels":[],"label_agreement":null},{"id":"W4232479412","doi":"10.1139/o01-116","title":"The emerging role of class II histone deacetylases","year":2001,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"Boehringer Ingelheim Stiftung; Fonds De La Recherche Scientifique - FNRS; Centre International de Recherche sur le Cancer; Gladstone Institutes","keywords":"HDAC4; Corepressor; Histone; Biology; HDAC11; Histone Acetyltransferases; Histone methyltransferase; Histone deacetylase 5; Histone code; Histone deacetylase; Chromatin; Histone deacetylase 2; Acetylation; Genetics; Transcriptional regulation; Histone H2A; SAP30; Cell biology; Repressor; Transcription factor; Gene; Nucleosome","score_opus":0.00620145437478505,"score_gpt":0.2621294169623262,"score_spread":0.2559279625875412,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4232479412","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.058067054,0.8933499,0.018933572,0.0059703025,0.0018505509,0.000022226972,0.00024528409,0.00028374788,0.021277308],"genre_scores_gemma":[0.3134671,0.65081036,0.011801543,0.002870503,0.0024366407,0.000038635608,0.000527491,0.000037256556,0.018010413],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998882,0.000010692316,0.0000075058997,0.00003574934,0.00003137107,0.00002652506],"domain_scores_gemma":[0.9999019,0.000015526388,0.000018667399,0.000009728025,0.000026416898,0.000027642616],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026112708,0.00038606027,0.00039808004,0.00023947946,0.00021444891,0.001011815,0.00027569517,0.00046678915,0.00156017],"category_scores_gemma":[0.00015791542,0.00009926559,0.00020208626,0.00028377486,0.00048109246,0.0007436805,0.00032260656,0.0009450093,0.00072768173],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040625493,0.0000624731,0.004405091,0.0017818752,0.00007399792,0.0007566966,0.00022092521,0.00048691954,0.52055514,0.043408234,0.007916712,0.4199257],"study_design_scores_gemma":[0.000033973312,0.00039170284,0.01532268,0.00013533002,0.000090093024,0.0033935814,0.00023255502,0.00083473854,0.10924195,0.017770212,0.85251856,0.000034704513],"about_ca_topic_score_codex":0.00040881112,"about_ca_topic_score_gemma":0.0005874408,"teacher_disagreement_score":0.00156017,"about_ca_system_score_codex":0.00046321936,"about_ca_system_score_gemma":0.0004276775,"threshold_uncertainty_score":0.0052193403},"labels":[],"label_agreement":null},{"id":"W4233022454","doi":"10.3410/f.717987468.793472458","title":"Faculty Opinions recommendation of Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion.","year":2013,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"Protein kinase B; Histone deacetylase; Chemistry; Histone; Secretion; Phosphatase; Leucine-rich repeat; Cancer research; Protein phosphatase 2; Cell biology; Signal transduction; Phosphorylation; Biology; Biochemistry; Receptor; Gene","score_opus":0.016984823498349004,"score_gpt":0.357008395676872,"score_spread":0.34002357217852297,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4233022454","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00067589857,0.0004587789,0.00010968436,0.00021839296,0.000053573676,0.000020630929,0.9970233,0.00040428585,0.001035378],"genre_scores_gemma":[0.0014812783,0.00023051344,0.00043466061,0.00013403979,0.000016509905,0.00006278384,0.9964329,0.00005302279,0.0011542464],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.998944,0.0001697759,0.00011129515,0.00033486204,0.00031734258,0.00012265137],"domain_scores_gemma":[0.99784195,0.0007673282,0.00028942208,0.00032064898,0.0005118505,0.00026883927],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011598786,0.0022915374,0.0015223295,0.002441767,0.000646923,0.0019786581,0.0022751377,0.0023373887,0.03212936],"category_scores_gemma":[0.0062729693,0.00046787917,0.0021701541,0.0032382386,0.00031717296,0.0009931992,0.0012037118,0.0014005064,0.0323081],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003611785,0.00006932802,0.0036275953,0.0018168135,0.00021494062,0.00004872289,0.000016978742,0.0005627372,0.00038249636,0.00028166085,0.98584634,0.0067712613],"study_design_scores_gemma":[0.0013490077,0.00011404266,0.027430864,0.00084767747,0.0004983559,0.00025435138,0.000081946084,0.0023920913,0.002194871,0.0013845267,0.96337104,0.00008122011],"about_ca_topic_score_codex":0.024735754,"about_ca_topic_score_gemma":0.071869,"teacher_disagreement_score":0.03212936,"about_ca_system_score_codex":0.0015931618,"about_ca_system_score_gemma":0.0025222567,"threshold_uncertainty_score":0.10748339},"labels":[],"label_agreement":null},{"id":"W4234817565","doi":"10.1139/bcb-79-3-243","title":"Class II histone deacetylases: Structure, function, and regulation","year":2001,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Histone; Function (biology); Cell biology; Biology; Chemistry; Histone methyltransferase; Genetics; Biochemistry; Gene","score_opus":0.0066740250460679456,"score_gpt":0.24702683492567398,"score_spread":0.24035280987960603,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4234817565","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.21325754,0.7318307,0.031641643,0.0038183285,0.0013606233,0.00006583163,0.0010820738,0.00049185805,0.016451364],"genre_scores_gemma":[0.71780163,0.23620628,0.009358996,0.000703026,0.00092247914,0.00005863242,0.0019407267,0.00008575668,0.032922454],"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","domain_scores_codex":[0.9998952,0.000007637005,0.0000047040444,0.00003231666,0.00003381329,0.000026354668],"domain_scores_gemma":[0.99987745,0.000008934231,0.000027193,0.000012280808,0.000031836924,0.000042360163],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023149783,0.0004823115,0.00035813384,0.00030939464,0.00030028608,0.0011729331,0.0005339961,0.0003577242,0.001355019],"category_scores_gemma":[0.00020755491,0.0001761153,0.00017924301,0.0004908347,0.0004419515,0.00062986306,0.00019581355,0.00076109916,0.0009867375],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010856916,0.00013018872,0.0050528534,0.0005510274,0.000064726744,0.00019879693,0.00010777699,0.0005844037,0.80774075,0.01715533,0.0049394374,0.16238903],"study_design_scores_gemma":[0.00016301655,0.0005781434,0.051676158,0.00010105501,0.00017507278,0.0024094824,0.0003485994,0.0030309192,0.6609489,0.011773614,0.26872453,0.000070482536],"about_ca_topic_score_codex":0.0037757847,"about_ca_topic_score_gemma":0.004905371,"teacher_disagreement_score":0.0037757847,"about_ca_system_score_codex":0.0013502673,"about_ca_system_score_gemma":0.00066502346,"threshold_uncertainty_score":0.009796917},"labels":[],"label_agreement":null},{"id":"W4235063194","doi":"10.1007/s40274-018-5025-9","title":"Midostaurin a cost-effective option for AML in Canada","year":2018,"lang":"en","type":"article","venue":"PharmacoEconomics & Outcomes News","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Quality of Life Research; Midostaurin; Medicine; Public health; Leukemia; Internal medicine; Nursing","score_opus":0.015649525705426055,"score_gpt":0.35152467229114187,"score_spread":0.3358751465857158,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4235063194","genre_codex":"commentary","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.15639657,0.06957985,0.0014968024,0.58296084,0.00641955,0.0003906927,0.0068327542,0.0005453293,0.17537767],"genre_scores_gemma":[0.73965216,0.075794086,0.0038510012,0.06700533,0.003964581,0.000098534474,0.0054431744,0.00016267775,0.10402846],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9995004,0.000027697897,0.00002044903,0.00003734286,0.00023498954,0.00017912131],"domain_scores_gemma":[0.998279,0.00009964953,0.00007540155,0.000014312692,0.0003199782,0.0012115677],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032108708,0.00021524905,0.00031972927,0.0006642134,0.0011695604,0.0014208663,0.0008305257,0.0015298816,0.019626101],"category_scores_gemma":[0.0013373533,0.00014572813,0.0005285882,0.00096092164,0.00080031424,0.00041170442,0.0005392203,0.0020778358,0.0010369478],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0032599831,0.00048605097,0.015171023,0.00050460076,0.00013897229,0.004340505,0.00015958252,0.0017185656,0.005799689,0.016037969,0.5249902,0.4273929],"study_design_scores_gemma":[0.00222679,0.0009201256,0.084639005,0.0007758912,0.00025250038,0.0032573782,0.00072858244,0.0020270147,0.0019508051,0.004153409,0.8989401,0.00012838059],"about_ca_topic_score_codex":0.82672435,"about_ca_topic_score_gemma":0.94078803,"teacher_disagreement_score":0.17327565,"about_ca_system_score_codex":0.026532952,"about_ca_system_score_gemma":0.056046173,"threshold_uncertainty_score":0.34859216},"labels":[],"label_agreement":null},{"id":"W4237018432","doi":"10.3410/f.738253697.793579931","title":"Faculty Opinions recommendation of First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Dual (grammatical number); Protein kinase B; Cancer research; Internal medicine; Chemistry; Medicine; Art; Biochemistry; Signal transduction; Literature","score_opus":0.018963711147087076,"score_gpt":0.3401919656361398,"score_spread":0.32122825448905273,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4237018432","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00020872973,0.0001853604,0.000066544555,0.00021570103,0.000043854554,0.000023589855,0.9977518,0.00012245442,0.0013820733],"genre_scores_gemma":[0.0022521657,0.0002904239,0.0004045099,0.0006425035,0.000078590274,0.00020133793,0.9928549,0.00010859315,0.00316696],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99855214,0.00027759944,0.00023241196,0.00046262267,0.00030206185,0.00017311084],"domain_scores_gemma":[0.9931393,0.0028020658,0.0011023729,0.0010309296,0.0009989254,0.0009264436],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017269924,0.0011625229,0.0018727384,0.001621441,0.00050637015,0.0021517721,0.0017848043,0.0023535665,0.17189144],"category_scores_gemma":[0.015386754,0.0005035801,0.0017564328,0.0030843432,0.00022430257,0.0011967403,0.0013320849,0.0013311001,0.070180155],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004463644,0.000026833352,0.0023419103,0.0012891806,0.00015150502,0.00003072937,0.000006920821,0.0001258684,0.000119042015,0.00021674085,0.99074066,0.00450418],"study_design_scores_gemma":[0.0032843526,0.00012121819,0.019435257,0.00135696,0.00053137494,0.00017177507,0.00003649821,0.00055780524,0.0005556354,0.0020655827,0.97183156,0.000051953833],"about_ca_topic_score_codex":0.010853172,"about_ca_topic_score_gemma":0.032376643,"teacher_disagreement_score":0.17189144,"about_ca_system_score_codex":0.0011755527,"about_ca_system_score_gemma":0.0031748202,"threshold_uncertainty_score":0.57503414},"labels":[],"label_agreement":null},{"id":"W4238016183","doi":"10.5539/cco.v7n2p54","title":"Reviewer Acknowledgements for Cancer and Clinical Oncology, Vol. 7, No. 2","year":2018,"lang":"en","type":"article","venue":"Cancer and Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Library science; Medicine; Wright; Cancer; Gerontology; Family medicine; History; Internal medicine; Art history","score_opus":0.09213897173111694,"score_gpt":0.5108412835851288,"score_spread":0.41870231185401185,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4238016183","genre_codex":"editorial","genre_gemma":"editorial","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"editorial","genre_consensus":"editorial","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00015193007,0.0043977397,0.0026910522,0.10194709,0.8827826,0.0009166244,0.00064470386,0.00073800073,0.00573019],"genre_scores_gemma":[0.006587241,0.010344282,0.008090015,0.14177047,0.7352939,0.0052159484,0.0021527568,0.0025689069,0.08797646],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9344193,0.014607472,0.010088421,0.0045181788,0.034245726,0.002120915],"domain_scores_gemma":[0.24853665,0.03331647,0.015373965,0.010567868,0.6766791,0.015525914],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05281468,0.0028649415,0.003917619,0.007827612,0.004056206,0.011378588,0.004869485,0.00737045,0.08600861],"category_scores_gemma":[0.45892784,0.0012682291,0.003323014,0.0037781764,0.0023874524,0.005818343,0.0039945445,0.008306456,0.06460009],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000212977,0.0000035048513,0.000078115634,0.00026945307,0.000008340466,0.000032777833,0.000050669496,0.000007895217,0.000033387358,0.00019530686,0.9910216,0.008277744],"study_design_scores_gemma":[0.000051966857,0.000022729415,0.0003795385,0.0014460695,0.000032428172,0.0005859006,0.00021960914,0.0001317864,0.00012386293,0.001002962,0.9959571,0.000045967477],"about_ca_topic_score_codex":0.0016847261,"about_ca_topic_score_gemma":0.0028335871,"teacher_disagreement_score":0.08600861,"about_ca_system_score_codex":0.0050493535,"about_ca_system_score_gemma":0.015274958,"threshold_uncertainty_score":0.28772748},"labels":[],"label_agreement":null},{"id":"W4248562159","doi":"10.1111/j.1752-8062.2011.00382.x","title":"A ROUNDUP OF NEWS AND INFORMATION FROM OUR COMMUNITY","year":2012,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Medicine; Cancer; Breast cancer; Anaplastic lymphoma kinase; Metastatic breast cancer; Oncology; Internal medicine; Tamoxifen; Metastasis; Lung cancer; Exemestane; Circulating tumor cell","score_opus":0.05630572832857743,"score_gpt":0.3883772547338774,"score_spread":0.33207152640529997,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4248562159","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0002948293,0.03539667,0.00067856605,0.22384518,0.6904102,0.00020445797,0.0016394235,0.0012982991,0.04623238],"genre_scores_gemma":[0.0017215031,0.038860723,0.0015341695,0.27458176,0.43654898,0.00034682432,0.0026557553,0.00062655716,0.24312374],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99479806,0.0010033257,0.00036171742,0.00052367826,0.002760363,0.00055282994],"domain_scores_gemma":[0.97390115,0.004651229,0.0013599191,0.0012866748,0.00967352,0.009127415],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00476582,0.0027001847,0.0025905026,0.0034193841,0.003161227,0.012428718,0.003242004,0.013626039,0.25545377],"category_scores_gemma":[0.020894272,0.00078223133,0.0017415306,0.0037348508,0.0021221025,0.009818431,0.006228634,0.013974049,0.16882814],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000022443957,0.000017176391,0.000023234159,0.00013525774,0.0000035582655,0.000039645627,0.000013117602,0.000009603873,0.000049938717,0.00013731347,0.9829773,0.016571509],"study_design_scores_gemma":[0.000016481568,0.000020370348,0.00017499978,0.00021420166,0.0000038682074,0.000053433083,0.00007890928,0.000015069467,0.00002620046,0.00023340927,0.9991493,0.000013702403],"about_ca_topic_score_codex":0.002232301,"about_ca_topic_score_gemma":0.004049356,"teacher_disagreement_score":0.25545377,"about_ca_system_score_codex":0.002140578,"about_ca_system_score_gemma":0.005130532,"threshold_uncertainty_score":0.85457796},"labels":[],"label_agreement":null},{"id":"W4249422946","doi":"10.1016/j.febslet.2014.05.001","title":"Tumor suppression","year":2014,"lang":"en","type":"editorial","venue":"FEBS Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Cancer; International agency; Lung cancer; Breast cancer; Medicine; Colorectal cancer; Epigenetics; Disease; Oncology; Gerontology; Cancer research; Demography; Internal medicine; Biology; Genetics","score_opus":0.004694411930831404,"score_gpt":0.25981501090412384,"score_spread":0.2551205989732924,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4249422946","genre_codex":"other","genre_gemma":"editorial","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"editorial","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.03561348,0.1232782,0.035717558,0.026794236,0.018052517,0.0012447857,0.02365667,0.011334466,0.72430813],"genre_scores_gemma":[0.1840538,0.06901619,0.018277884,0.02318946,0.0044121766,0.0015470599,0.035205953,0.0022063479,0.6620911],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99910706,0.0001287821,0.000054571756,0.0002095943,0.0003462012,0.00015378915],"domain_scores_gemma":[0.99921536,0.00009705779,0.00008158865,0.00015006334,0.0002815921,0.00017427819],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00083457003,0.0008333756,0.0008478708,0.0011558227,0.0011026842,0.0027710262,0.0013289277,0.0017047419,0.13309737],"category_scores_gemma":[0.0017344375,0.00035576947,0.0009956155,0.0010961399,0.0006812091,0.0014921834,0.001944805,0.0024271274,0.08922122],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006435594,0.0003246191,0.0034377861,0.0018125641,0.000114847884,0.00119738,0.000321039,0.00046616042,0.038574424,0.02440406,0.3886998,0.5400038],"study_design_scores_gemma":[0.000047299014,0.00012755081,0.0009990019,0.0001625365,0.000030425632,0.0015143936,0.00007625492,0.00014792274,0.0065363874,0.0020289859,0.98831534,0.000014016407],"about_ca_topic_score_codex":0.0012676779,"about_ca_topic_score_gemma":0.0015520406,"teacher_disagreement_score":0.13309737,"about_ca_system_score_codex":0.0009713961,"about_ca_system_score_gemma":0.0014226265,"threshold_uncertainty_score":0.44525504},"labels":[],"label_agreement":null},{"id":"W4254343589","doi":"10.1158/1538-7445.am2019-4332","title":"Abstract 4332: Targeting MYC overexpressing leukemia with cardiac glycoside proscillaridin through downregulation of histone acetyltransferases","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Concordia University; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Downregulation and upregulation; Cancer research; Histone Acetyltransferases; Histone acetyltransferase; Acetylation; Histone; Biology; Histone H3; HDAC3; Molecular biology; Histone deacetylase; Biochemistry; Gene","score_opus":0.027274995950676603,"score_gpt":0.3760061267141482,"score_spread":0.34873113076347156,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4254343589","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95479983,0.0070759263,0.01538498,0.0010967307,0.00051402516,0.00015650285,0.0016035531,0.0007482721,0.018620053],"genre_scores_gemma":[0.9333582,0.005827719,0.0100857,0.00048891356,0.00009361813,0.000115598865,0.0020091217,0.000109917724,0.0479113],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.99995565,0.0000052028295,0.0000038633366,0.000009108116,0.000016639211,0.00000956662],"domain_scores_gemma":[0.99997616,0.0000020482726,0.0000065308373,0.0000023765322,0.000006429169,0.000006411266],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007952203,0.00028118832,0.00015173786,0.00016949979,0.00012188379,0.00021954921,0.00018027362,0.00028094635,0.0024578108],"category_scores_gemma":[0.00004678402,0.00008059234,0.000118626886,0.00014410533,0.0001079437,0.00016223056,0.00017728728,0.0003811064,0.00086390047],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014954132,0.00001810901,0.000048491165,0.000035679936,0.0000028095074,0.000046215515,0.0000042468523,0.00006398954,0.9957698,0.00013849977,0.00031064442,0.0034119454],"study_design_scores_gemma":[0.000025176076,0.00025862892,0.0020393196,0.000005767356,0.0000122543215,0.00030748852,0.000008265012,0.00049338856,0.9810385,0.00006233338,0.0157444,0.0000044813696],"about_ca_topic_score_codex":0.00032494226,"about_ca_topic_score_gemma":0.0003621018,"teacher_disagreement_score":0.0024578108,"about_ca_system_score_codex":0.00025168902,"about_ca_system_score_gemma":0.0001487315,"threshold_uncertainty_score":0.008222163},"labels":[],"label_agreement":null},{"id":"W4256013073","doi":"10.3410/f.1091088.544475","title":"Faculty Opinions recommendation of Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.","year":2007,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Hepatocyte growth factor; Matrix metalloproteinase; Hepatocyte; Metastasis; Cancer research; Signal transduction; Cell biology; Chemistry; Medicine; Biology; Internal medicine; Cancer; Biochemistry; Receptor; In vitro","score_opus":0.03256595538087466,"score_gpt":0.3539266999130557,"score_spread":0.32136074453218105,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4256013073","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00069215184,0.00024742156,0.00008116691,0.00015793352,0.00003082882,0.000013102011,0.997644,0.00027290208,0.0008605597],"genre_scores_gemma":[0.0013235301,0.00014877423,0.00032205673,0.00006000214,0.000010949421,0.0000339387,0.99705195,0.000039246923,0.0010095222],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.998922,0.00017031444,0.00009809115,0.0003074678,0.000378522,0.00012352435],"domain_scores_gemma":[0.9976851,0.00070051587,0.00037047514,0.0003986753,0.0005456255,0.00029960976],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009471154,0.002130723,0.001463135,0.0030442986,0.0005559614,0.0018405548,0.002128201,0.0018654278,0.03589985],"category_scores_gemma":[0.0053888676,0.0005242729,0.0014838199,0.0042109727,0.0002370564,0.0008365757,0.0009966043,0.0013517283,0.034430936],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023811612,0.000057160458,0.0031515688,0.0010201067,0.0001287071,0.000034400753,0.00001119102,0.0004056159,0.00042488115,0.00021345,0.98784596,0.0064687706],"study_design_scores_gemma":[0.000964426,0.00009825566,0.03783527,0.0004568591,0.00041014652,0.00021591737,0.00006598416,0.0029709768,0.003501062,0.0010265968,0.9523893,0.000065178865],"about_ca_topic_score_codex":0.020312792,"about_ca_topic_score_gemma":0.0486491,"teacher_disagreement_score":0.03589985,"about_ca_system_score_codex":0.0010970786,"about_ca_system_score_gemma":0.002723345,"threshold_uncertainty_score":0.12009698},"labels":[],"label_agreement":null},{"id":"W4280533786","doi":"10.3389/fonc.2022.875122","title":"High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Jarislowsky Foundation","keywords":"Histone deacetylase; Cancer research; HDAC11; Histone deacetylase 5; Medicine; Internal medicine; Histone; Oncology; Biology; Genetics; Gene","score_opus":0.006774967146612971,"score_gpt":0.2765021547729483,"score_spread":0.26972718762633535,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4280533786","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99112076,0.004030473,0.0019090662,0.00010899322,0.00003601568,0.000019197574,0.0005121422,0.00009171001,0.0021715688],"genre_scores_gemma":[0.9967153,0.0008226406,0.00078237586,0.000036530106,0.000013501711,0.000011010783,0.00043006137,0.00001096386,0.0011775522],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998739,0.000010701691,0.000011213694,0.00002948903,0.00004726732,0.000027386062],"domain_scores_gemma":[0.99986684,0.00002480181,0.000040297065,0.000012838204,0.0000141413375,0.000041045867],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016411924,0.00018584989,0.00019888688,0.00047444593,0.00018117642,0.00032653412,0.00013339127,0.00020578264,0.001719721],"category_scores_gemma":[0.00016050525,0.000097175616,0.0002163348,0.0002711657,0.000290516,0.00013450733,0.00015875515,0.000361629,0.00025293874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018913057,0.000011970452,0.0029308668,0.0000355573,0.000008362056,0.0005311231,0.000030067837,0.000019970865,0.9941157,0.00005298446,0.000051755054,0.002022364],"study_design_scores_gemma":[0.000038930342,0.0004985553,0.13409442,0.000008623283,0.00004602285,0.007443206,0.00021898391,0.0004279074,0.8506301,0.00018857334,0.006393621,0.00001097078],"about_ca_topic_score_codex":0.001593995,"about_ca_topic_score_gemma":0.0018516302,"teacher_disagreement_score":0.001719721,"about_ca_system_score_codex":0.00037253147,"about_ca_system_score_gemma":0.00025705496,"threshold_uncertainty_score":0.0057530403},"labels":[],"label_agreement":null},{"id":"W4280608996","doi":"10.1172/jci148333","title":"HDAC6 modulates myofibril stiffness and diastolic function of the heart","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Institute on Aging; American Heart Association; Canadian Institutes of Health Research; Anschutz Medical Campus, University of Colorado; National Center for Advancing Translational Sciences; Italfarmaco; Small Business Innovation Research; Novo Nordisk; National Institutes of Health; Eikonizo Therapeutics; Novo Nordisk Fonden; Boettcher Foundation","keywords":"Titin; Myofibril; Sarcomere; HDAC6; Obscurin; Diastole; Internal medicine; Cardiomyopathy; Myofilament; Myocyte; Chemistry; Histone deacetylase; Cell biology; Heart failure; Medicine; Biology; Biochemistry; Histone","score_opus":0.04543004352491622,"score_gpt":0.34697587371279265,"score_spread":0.30154583018787645,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4280608996","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98713255,0.007494275,0.0016039857,0.00026857207,0.00010037144,0.000022726463,0.00041700565,0.000086847605,0.0028737697],"genre_scores_gemma":[0.9934896,0.0025392442,0.00065837556,0.00006584599,0.000031582287,0.000011426724,0.00030947354,0.000011670934,0.0028828038],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999294,0.00001039918,0.0000070197616,0.00001530176,0.000014702725,0.000023163677],"domain_scores_gemma":[0.999956,0.000003752587,0.000012867801,0.000004451584,0.0000066499797,0.000016234606],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119984776,0.00024554922,0.00018893449,0.00013065587,0.00011712634,0.00026207685,0.00018100289,0.00017504317,0.0012354278],"category_scores_gemma":[0.00009384715,0.00010938794,0.00018799539,0.000091095884,0.00017646022,0.00013531419,0.00011441474,0.00032830308,0.00028442845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029860856,0.00003580435,0.0008186597,0.000043205222,0.000012747444,0.00002305417,0.000008852653,0.00003876139,0.9953768,0.00007715677,0.00009202656,0.003174281],"study_design_scores_gemma":[0.00013091468,0.0009105098,0.051811464,0.000013442057,0.00008591475,0.00033174254,0.000061380015,0.0012544022,0.9390145,0.00012136067,0.0062552136,0.000009053362],"about_ca_topic_score_codex":0.00040769065,"about_ca_topic_score_gemma":0.0014351255,"teacher_disagreement_score":0.0012354278,"about_ca_system_score_codex":0.0002232954,"about_ca_system_score_gemma":0.00014361081,"threshold_uncertainty_score":0.0041329265},"labels":[],"label_agreement":null},{"id":"W4282946865","doi":"10.1139/cjpp-2021-0799","title":"Enhanced antitumor activity of combined methotrexate and histone deacetylase inhibitor valproic acid on mammary cancer in vitro and in vivo","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Valproic Acid; In vivo; Pharmacology; Methotrexate; Histone deacetylase; Cytotoxicity; Histone deacetylase inhibitor; Chemistry; In vitro; Mammary tumor; Cancer research; Cancer; Breast cancer; Biology; Medicine; Internal medicine; Biochemistry; Immunology; Histone; Epilepsy","score_opus":0.010713682258900237,"score_gpt":0.3021156829965442,"score_spread":0.29140200073764394,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4282946865","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9873378,0.008889192,0.00094331225,0.0001290528,0.0000677813,0.000029441606,0.00027771018,0.000072085,0.0022536118],"genre_scores_gemma":[0.99365944,0.0028692235,0.00084534485,0.000039108912,0.000028377195,0.000022267079,0.00028441826,0.000010867157,0.0022409463],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999161,0.000017865481,0.000006484384,0.000016024322,0.000020105404,0.000023420682],"domain_scores_gemma":[0.99995124,0.000007911203,0.000010579718,0.0000060142165,0.000006409444,0.000017808374],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009071005,0.00029291786,0.00042216686,0.00029745325,0.00009509065,0.00016120743,0.00017159217,0.00018542242,0.0011232145],"category_scores_gemma":[0.000085967855,0.00009973031,0.00018950895,0.00018341065,0.00012082118,0.00014695161,0.000112177186,0.00041156413,0.00017604243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000819944,0.00018398842,0.0002526032,0.00007855527,0.000020302841,0.00004653207,0.000018571205,0.00015150505,0.99278754,0.000054089454,0.000084719424,0.0055016587],"study_design_scores_gemma":[0.00010768343,0.0057311477,0.0042512645,0.00001156223,0.00008665803,0.0002509526,0.000020880443,0.0006457402,0.9854439,0.00003440631,0.0034104744,0.000005272756],"about_ca_topic_score_codex":0.00090650824,"about_ca_topic_score_gemma":0.0019269207,"teacher_disagreement_score":0.0011232145,"about_ca_system_score_codex":0.00019928059,"about_ca_system_score_gemma":0.00023246775,"threshold_uncertainty_score":0.0037575364},"labels":[],"label_agreement":null},{"id":"W4285112075","doi":"10.20517/cdr.2022.36","title":"Base excision repair accessory factors in senescence avoidance and resistance to treatments","year":2022,"lang":"en","type":"review","venue":"Cancer Drug Resistance","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"DNA damage; Senescence; DNA repair; Biology; Base excision repair; Oxidative stress; Cell biology; Cancer cell; Cancer research; Reactive oxygen species; Cancer; Genetics; DNA; Biochemistry","score_opus":0.04487092346915068,"score_gpt":0.3636242295136351,"score_spread":0.31875330604448443,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4285112075","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.004301908,0.990776,0.0011355396,0.0003641058,0.0003431311,0.0000134444945,0.000050083723,0.000033148684,0.0029827347],"genre_scores_gemma":[0.03971256,0.95166194,0.0017665131,0.0005463165,0.0004608253,0.000037858823,0.00022045558,0.000014349663,0.0055791065],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998097,0.00003803791,0.000030739066,0.000036560716,0.000058332942,0.000026704423],"domain_scores_gemma":[0.99983525,0.00005456499,0.000036160687,0.000005856071,0.000053781525,0.000014402396],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003245296,0.0004115873,0.0005844332,0.00088992395,0.00016144033,0.0007911006,0.00036406645,0.0007293647,0.001414752],"category_scores_gemma":[0.00045702397,0.00014503722,0.00036597953,0.00054483453,0.00028055315,0.0006546052,0.00031368312,0.000940977,0.00064118963],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003591051,0.00013374974,0.0012515909,0.023044262,0.00023213589,0.0010816009,0.00054058875,0.0010701045,0.115484424,0.019707141,0.019871254,0.8172241],"study_design_scores_gemma":[0.000022274206,0.0002913426,0.0033321737,0.0013829902,0.00015914095,0.002520233,0.00011429865,0.0002666584,0.02295222,0.0029456962,0.96598023,0.00003266237],"about_ca_topic_score_codex":0.00035380726,"about_ca_topic_score_gemma":0.0005058892,"teacher_disagreement_score":0.001414752,"about_ca_system_score_codex":0.000444578,"about_ca_system_score_gemma":0.0003824306,"threshold_uncertainty_score":0.0047327876},"labels":[],"label_agreement":null},{"id":"W4285741616","doi":"10.3389/fphar.2022.856804","title":"Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Association Vaincre la Mucoviscidose; University of California, San Francisco; University of Toronto; Agence Nationale de la Recherche","keywords":"Proteasome; Limb-girdle muscular dystrophy; Protein degradation; Bortezomib; Biology; Genetics; Medicine; Mutation; Pharmacology; Cell biology; Gene; Internal medicine","score_opus":0.0052893944359556876,"score_gpt":0.2573828866065089,"score_spread":0.2520934921705532,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4285741616","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99369484,0.0023037954,0.001646899,0.0001311697,0.00005142914,0.00008622203,0.0003254808,0.00009011543,0.001669964],"genre_scores_gemma":[0.9945755,0.0011733477,0.0024931151,0.000046924797,0.000010710745,0.000038753944,0.00038361576,0.000012044138,0.0012660684],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999074,0.000014880674,0.000009379379,0.000018948675,0.000027722046,0.000021632346],"domain_scores_gemma":[0.9999505,0.000007687029,0.000011388463,0.000006852436,0.0000062873632,0.000017130216],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011503545,0.00029795847,0.00045386943,0.00024274334,0.00008995718,0.00022686941,0.00018287437,0.0001987413,0.0010237917],"category_scores_gemma":[0.00007916514,0.00007150393,0.00023052606,0.0001699808,0.00015139897,0.0001183538,0.00013349853,0.00045711087,0.00017436717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00079157,0.00019456285,0.0003648645,0.00008315959,0.000034457207,0.00011074497,0.000013083794,0.0003882818,0.99092406,0.00010003276,0.00010581144,0.0068894075],"study_design_scores_gemma":[0.00015047434,0.0039599347,0.0028138985,0.000006984023,0.000073439965,0.00040186077,0.000024373729,0.0014092609,0.9880376,0.00005455087,0.0030596356,0.000007903638],"about_ca_topic_score_codex":0.00039037474,"about_ca_topic_score_gemma":0.0013602815,"teacher_disagreement_score":0.0010237917,"about_ca_system_score_codex":0.0002424445,"about_ca_system_score_gemma":0.00023932333,"threshold_uncertainty_score":0.0034249425},"labels":[],"label_agreement":null},{"id":"W4285797617","doi":"10.1038/s41467-022-30653-5","title":"[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Center for Research Resources; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; National Institute on Aging; National Institutes of Health; National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; Centre d'Imagerie BioMédicale; Canadian Institutes of Health Research; Weston Brain Institute; Alzheimer's Drug Discovery Foundation; American Federation for Aging Research","keywords":"Alzheimer's disease; Disease; Computational biology; Medicine; Biology; Pathology","score_opus":0.025220249692038767,"score_gpt":0.3467667079292664,"score_spread":0.3215464582372276,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4285797617","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99051356,0.0029978354,0.0028268315,0.00023659652,0.000039068465,0.00001059023,0.0007851999,0.0001095953,0.0024806694],"genre_scores_gemma":[0.99542433,0.00110252,0.00135933,0.000112910195,0.000012152854,0.000017142065,0.0004454602,0.00002425214,0.001501999],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994063,0.0000060746956,0.000004580399,0.000017169694,0.0000092088385,0.00002238637],"domain_scores_gemma":[0.9999559,0.0000070451715,0.000012390594,0.0000049542314,0.0000072547437,0.0000123819],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015371371,0.00042723742,0.0003790274,0.0004529456,0.00017609783,0.00037741568,0.00030634383,0.000492051,0.0022727577],"category_scores_gemma":[0.00011882864,0.00025954275,0.00034266402,0.00020857382,0.0003387735,0.00019651027,0.00013049414,0.00044088485,0.00043695627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011199496,0.000060674887,0.004343084,0.00006860857,0.00006390894,0.00068492955,0.000055961664,0.000106999985,0.9895223,0.00015533822,0.00021533774,0.0036028891],"study_design_scores_gemma":[0.00016444718,0.0013575344,0.17988612,0.000029147232,0.000351961,0.0070206765,0.00025482711,0.0024513227,0.8027766,0.00068818015,0.004988851,0.000030327958],"about_ca_topic_score_codex":0.0020358707,"about_ca_topic_score_gemma":0.0017784449,"teacher_disagreement_score":0.0022727577,"about_ca_system_score_codex":0.00035781594,"about_ca_system_score_gemma":0.00013948277,"threshold_uncertainty_score":0.007603109},"labels":[],"label_agreement":null},{"id":"W4292065316","doi":"10.1172/jci159283","title":"HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; Government of Ontario; Terry Fox Research Institute; Canadian Cancer Society; Ontario Institute for Cancer Research","keywords":"Epitope; Immunity; Tumor microenvironment; Inflammation; Cancer research; Immunology; Immune system; Cell biology; Biology; Chemistry; Antigen","score_opus":0.0292737729577458,"score_gpt":0.34655608990629405,"score_spread":0.31728231694854825,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4292065316","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9909338,0.0027920287,0.0029360156,0.0001631136,0.00006791855,0.0000668117,0.00023678405,0.00013030173,0.0026731896],"genre_scores_gemma":[0.99685717,0.0006551838,0.00095021527,0.000035023284,0.000014916314,0.000016988306,0.00010476123,0.000007684098,0.001357883],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991953,0.000012124811,0.000005345885,0.000013817776,0.0000202955,0.00002894636],"domain_scores_gemma":[0.9999653,0.000004057041,0.000008920678,0.0000033262813,0.000004036055,0.000014274562],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012334257,0.0003557478,0.00019499953,0.0001995186,0.00009151651,0.00027762278,0.0001400517,0.000116718504,0.0014914059],"category_scores_gemma":[0.000055397988,0.00009343808,0.00019515856,0.00010913965,0.00019669547,0.00013531999,0.00013375017,0.00050231564,0.00030473588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023129632,0.00008673546,0.00025419897,0.00003997961,0.000006210571,0.000024875473,0.00000767236,0.000118160075,0.9955289,0.000107231244,0.00007128068,0.0035235216],"study_design_scores_gemma":[0.000050853054,0.00088461436,0.003632402,0.000004457161,0.00002078502,0.00011589006,0.000023945231,0.0011469512,0.9919688,0.000038518796,0.0021094766,0.0000032452924],"about_ca_topic_score_codex":0.0005006486,"about_ca_topic_score_gemma":0.0013994684,"teacher_disagreement_score":0.0014914059,"about_ca_system_score_codex":0.00031027754,"about_ca_system_score_gemma":0.00027107808,"threshold_uncertainty_score":0.004989207},"labels":[],"label_agreement":null},{"id":"W4292813687","doi":"10.1139/apnm-2022-0174","title":"Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin–proteasome system in skeletal muscle","year":2022,"lang":"en","type":"article","venue":"Applied Physiology Nutrition and Metabolism","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"HDAC4; MG132; AMPK; Endocrinology; Histone deacetylase 5; Internal medicine; Protein degradation; Skeletal muscle; Soleus muscle; Ubiquitin; Proteasome; Biology; Chemistry; Histone deacetylase; Cell biology; Biochemistry; Medicine; Proteasome inhibitor; Histone; Phosphorylation; Protein kinase A","score_opus":0.007380050127503442,"score_gpt":0.23687242934638292,"score_spread":0.22949237921887947,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4292813687","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99062645,0.0060657556,0.0016706524,0.00017650964,0.00012472131,0.00004464089,0.00034415303,0.00012144943,0.0008256412],"genre_scores_gemma":[0.9920738,0.0028467237,0.001563688,0.00014764341,0.000033689124,0.000078715144,0.000861843,0.000020483883,0.0023734907],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998504,0.00001813741,0.000025900166,0.00003551373,0.000028562548,0.0000414359],"domain_scores_gemma":[0.99994946,0.0000024704434,0.000017859535,0.0000061769483,0.000008131092,0.000015868398],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018086006,0.00051936007,0.0005007822,0.0003164683,0.00017013452,0.00021951238,0.00022377945,0.00028699494,0.0013137144],"category_scores_gemma":[0.00008318292,0.00018796169,0.00060216355,0.00015482683,0.00020514846,0.0002185017,0.0002294612,0.0006189889,0.00023410658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021133902,0.00050433504,0.0016280018,0.00032324155,0.0001087572,0.0000618285,0.000024939241,0.00009252004,0.9839293,0.000050052768,0.000199688,0.010963989],"study_design_scores_gemma":[0.0005601851,0.007047193,0.116470516,0.00009339526,0.00045771888,0.00040454036,0.00012783942,0.0017349622,0.86718386,0.00015673792,0.005737228,0.000025753207],"about_ca_topic_score_codex":0.0007674262,"about_ca_topic_score_gemma":0.0018627641,"teacher_disagreement_score":0.0013137144,"about_ca_system_score_codex":0.00021259485,"about_ca_system_score_gemma":0.0001781194,"threshold_uncertainty_score":0.0043948293},"labels":[],"label_agreement":null},{"id":"W4293799461","doi":"10.1139/cjc-2022-0056","title":"Driving the new generation histone deacetylase inhibitors in cancer therapy; manipulation of the histone abbreviation at the epigenetic level: an in-silico approach","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Chemistry; Trichostatin A; Histone deacetylase; Hydroxamic acid; Active site; Histone deacetylase inhibitor; Stereochemistry; Enzyme; Biochemistry; Histone; Gene","score_opus":0.03704438104792288,"score_gpt":0.2903794933501407,"score_spread":0.2533351123022178,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4293799461","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.36443898,0.008703051,0.57771057,0.0024918162,0.00038528483,0.00033838107,0.0031013133,0.0018565613,0.04097403],"genre_scores_gemma":[0.8020498,0.005936116,0.18157704,0.00046760595,0.000069957685,0.00045974524,0.0020989608,0.00025553777,0.0070852633],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99992204,0.00002267979,0.0000035134565,0.000013960386,0.00002560763,0.000012259672],"domain_scores_gemma":[0.9998754,0.00006366367,0.000017196446,0.000009060776,0.000023257851,0.000011450945],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028665888,0.00046289386,0.00072500366,0.0002568472,0.00022907842,0.0005393388,0.000621543,0.00058518985,0.002085589],"category_scores_gemma":[0.0003879601,0.00030292518,0.0007423964,0.00024604323,0.00015978618,0.00043677114,0.00026539926,0.0005161008,0.00042692598],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010553971,0.00013765236,0.0017225902,0.00035078428,0.00011677224,0.00016466159,0.000033653407,0.9518748,0.019844769,0.008411001,0.0012589429,0.015978832],"study_design_scores_gemma":[0.00002810566,0.00009825634,0.00022505541,0.0000154551,0.000051141786,0.00004427658,0.000019023208,0.9893063,0.0042120377,0.0017951403,0.0041968008,0.000008522835],"about_ca_topic_score_codex":0.0028271342,"about_ca_topic_score_gemma":0.0037207769,"teacher_disagreement_score":0.0028271342,"about_ca_system_score_codex":0.0004257744,"about_ca_system_score_gemma":0.0008434231,"threshold_uncertainty_score":0.0069770217},"labels":[],"label_agreement":null},{"id":"W4294796715","doi":"10.1038/s41388-022-02450-3","title":"Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition","year":2022,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"Deutsche Forschungsgemeinschaft; Carl-Zeiss-Stiftung","keywords":"Biology; Histone deacetylase; Cancer research; Histone deacetylase inhibitor; Histone; HDAC11; Lymphoma; Genetics; Computational biology; Gene; Immunology","score_opus":0.00916198145500541,"score_gpt":0.2705136250898769,"score_spread":0.2613516436348715,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4294796715","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9838563,0.007508612,0.0051016966,0.0002210769,0.00004743265,0.00003127975,0.0001994785,0.00023204595,0.0028021708],"genre_scores_gemma":[0.99311227,0.00237035,0.0021431725,0.000048664187,0.000010534802,0.00002111463,0.00026189533,0.000019666704,0.0020123278],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999316,0.00001175663,0.000004373001,0.000013216118,0.000021556034,0.000017454127],"domain_scores_gemma":[0.9999682,0.0000040779764,0.000010725681,0.000003270365,0.0000030637968,0.000010639889],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009235928,0.00026260962,0.00021188699,0.00018323271,0.00009539326,0.0002520204,0.00022450306,0.00016671317,0.0009801595],"category_scores_gemma":[0.00005690211,0.00012712834,0.0001935783,0.00015820644,0.00013110503,0.00014333516,0.00017592413,0.000512982,0.00039922394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011716836,0.000033989334,0.00011631089,0.000030303077,0.0000075137755,0.00003918911,0.000004143427,0.0001163779,0.99695325,0.00011923059,0.00005211745,0.0024103876],"study_design_scores_gemma":[0.000039395058,0.0003930657,0.0022510395,0.0000041531434,0.000027865937,0.00031398793,0.000008355039,0.0014729341,0.9902181,0.0000838122,0.0051844507,0.0000028975148],"about_ca_topic_score_codex":0.00020485838,"about_ca_topic_score_gemma":0.0006556335,"teacher_disagreement_score":0.0009801595,"about_ca_system_score_codex":0.00024015582,"about_ca_system_score_gemma":0.00011526231,"threshold_uncertainty_score":0.0032789707},"labels":[],"label_agreement":null},{"id":"W4300861845","doi":"10.1038/s41467-022-33668-0","title":"Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease","year":2022,"lang":"en","type":"erratum","venue":"Nature Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Disease; Computer science; Computational biology; Biology; Medicine; Pathology","score_opus":0.02930536153860761,"score_gpt":0.35886857177182874,"score_spread":0.3295632102332211,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4300861845","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0005472597,0.0012761415,0.0016662367,0.053408217,0.93895775,0.00001940674,0.0010696743,0.00047294438,0.002582414],"genre_scores_gemma":[0.042968784,0.011652999,0.013193367,0.13776259,0.31876564,0.00025237427,0.0033187645,0.003532692,0.46855277],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9983241,0.00017192878,0.00022576757,0.0003317483,0.0007815474,0.00016493801],"domain_scores_gemma":[0.9910556,0.00255073,0.0006366489,0.0006078882,0.0045726732,0.0005762988],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016907847,0.001578277,0.0013549861,0.0020074274,0.0019215755,0.0021700365,0.0025872248,0.006762839,0.025657153],"category_scores_gemma":[0.02056285,0.0009916465,0.0011337164,0.0010364678,0.0018150416,0.0011983031,0.0010300983,0.009097258,0.015921984],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007124256,0.0000099847575,0.00010288921,0.00011497511,0.000018152556,0.0013832336,0.00003182781,0.00006636004,0.00028190605,0.0006328243,0.9912866,0.0060000145],"study_design_scores_gemma":[0.00006464131,0.00003189311,0.00080452644,0.0001631275,0.00007907838,0.0034231783,0.00006524213,0.00036367108,0.002175643,0.0013405839,0.99144167,0.00004679443],"about_ca_topic_score_codex":0.01311771,"about_ca_topic_score_gemma":0.015660701,"teacher_disagreement_score":0.025657153,"about_ca_system_score_codex":0.0030070592,"about_ca_system_score_gemma":0.0028667785,"threshold_uncertainty_score":0.0858317},"labels":[],"label_agreement":null},{"id":"W4306730552","doi":"10.1007/978-1-0716-2788-4_31","title":"Fluorescence Polarization-Based Competition Assays to Evaluate Histone Deacetylase 6 Inhibitors","year":2022,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dairy Farmers of Ontario; University of Toronto","funders":"","keywords":"HDAC6; Acetylation; Histone deacetylase; Fluorescence anisotropy; HDAC10; Histone; Chemistry; Small molecule; Biochemistry; Computational biology; Cell biology; Biology; Cancer research","score_opus":0.01984529187038603,"score_gpt":0.3969581044235418,"score_spread":0.37711281255315576,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4306730552","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.380177,0.0051725144,0.57916576,0.0011593138,0.0007711986,0.0021484564,0.0047585587,0.0029360666,0.023711078],"genre_scores_gemma":[0.5685135,0.007965873,0.35060593,0.0009926398,0.0003966735,0.0068232478,0.01722619,0.0009758097,0.046500053],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9951218,0.0013989256,0.00019712654,0.00062761444,0.0016815434,0.00097294746],"domain_scores_gemma":[0.9975719,0.00095566484,0.00026959207,0.0002705613,0.00072357437,0.0002086161],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0023764174,0.005186127,0.002289162,0.0014732091,0.0014074804,0.0010953321,0.0031102838,0.0019109625,0.00684196],"category_scores_gemma":[0.0014658176,0.0014022447,0.0018049988,0.002695702,0.0008716235,0.0010105795,0.0011059426,0.0067432746,0.0032079893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004829871,0.0005014661,0.00016288499,0.00021265005,0.00007566387,0.00005460602,0.000058257832,0.0007468411,0.99239904,0.0007879042,0.0007572436,0.003760361],"study_design_scores_gemma":[0.000078431425,0.0004445153,0.00052201917,0.000009033132,0.00004263539,0.00010515341,0.00002285242,0.0038099268,0.9922401,0.00018394992,0.0025116073,0.000029842435],"about_ca_topic_score_codex":0.002589484,"about_ca_topic_score_gemma":0.0051786415,"teacher_disagreement_score":0.00684196,"about_ca_system_score_codex":0.0018871696,"about_ca_system_score_gemma":0.0011881709,"threshold_uncertainty_score":0.0228886},"labels":[],"label_agreement":null},{"id":"W4306731896","doi":"10.1007/978-1-0716-2788-4_11","title":"Evaluation of Small-Molecule HDAC Inhibitors Through In Vitro and In Cellulo Approaches","year":2022,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dairy Farmers of Ontario; University of Toronto","funders":"","keywords":"ADME; In vitro; Membrane permeability; Small molecule; Drug discovery; Chemistry; Histone deacetylase; Metabolic stability; Histone; Pharmacology; Biology; Biochemistry; Computational biology; Cell biology; Membrane; Gene","score_opus":0.0804663408143461,"score_gpt":0.4008934459548271,"score_spread":0.320427105140481,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4306731896","genre_codex":"empirical","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.89760405,0.024309188,0.048515193,0.0005616775,0.0005480024,0.00081778516,0.008254133,0.0005236289,0.018866396],"genre_scores_gemma":[0.9220928,0.021340298,0.032688156,0.0002533827,0.00007191072,0.00044541992,0.0073366314,0.00019090885,0.015580599],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995875,0.00008931986,0.000039026614,0.00006100939,0.00013945265,0.00008371497],"domain_scores_gemma":[0.9997522,0.00006151217,0.00006270468,0.00003256969,0.0000636497,0.00002734463],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00059688376,0.00096276455,0.00059632823,0.0003143091,0.00029940333,0.00086309086,0.00058696314,0.00046900802,0.0026666361],"category_scores_gemma":[0.0003632156,0.00025167415,0.00057234935,0.0004075873,0.0002598203,0.0003895201,0.0001972753,0.0012065892,0.0009407449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028510106,0.00018633621,0.00013293084,0.00015428409,0.00003795718,0.000037420632,0.000019353378,0.0010990462,0.9920576,0.00026828115,0.00022520294,0.0054964293],"study_design_scores_gemma":[0.000013800487,0.00028323097,0.00019139143,0.0000038787693,0.000026542724,0.000027714512,0.000011990255,0.00048482817,0.9959274,0.000016165963,0.0030084997,0.0000045972088],"about_ca_topic_score_codex":0.0037354417,"about_ca_topic_score_gemma":0.007171933,"teacher_disagreement_score":0.0037354417,"about_ca_system_score_codex":0.0010219992,"about_ca_system_score_gemma":0.0005686599,"threshold_uncertainty_score":0.008920729},"labels":[],"label_agreement":null},{"id":"W4307291218","doi":"10.3390/ph15111321","title":"High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Austrian Science Fund; Cancer Research Society","keywords":"Lymphoma; Cancer research; Etoposide; Romidepsin; Medicine; Pharmacology; Biology; Chemotherapy; Immunology; Internal medicine; Histone; Histone deacetylase; Gene","score_opus":0.011880749662289455,"score_gpt":0.30521141784285033,"score_spread":0.29333066818056086,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4307291218","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9898465,0.003951417,0.0013622231,0.00008052514,0.000055850473,0.000037550915,0.00030706718,0.00006736846,0.0042915544],"genre_scores_gemma":[0.99536043,0.0016115912,0.0008304693,0.000028777666,0.000009814114,0.000014579708,0.000342387,0.000009720834,0.0017922602],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999372,0.000011341359,0.0000057601032,0.000016029642,0.000019008206,0.000010729655],"domain_scores_gemma":[0.99997246,0.000004949662,0.0000041040753,0.0000036755275,0.000003969314,0.000010977567],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007942564,0.00014849259,0.00042280785,0.00011062721,0.00008036671,0.00015996394,0.000107116335,0.00011681871,0.0011310326],"category_scores_gemma":[0.00006520968,0.0000639438,0.00013246293,0.00010444872,0.00006776663,0.00012758229,0.00012708374,0.0004042712,0.0003011123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012278574,0.0004326576,0.0005960351,0.00013045469,0.000026314257,0.000120698285,0.0000339636,0.0007824489,0.96618325,0.00018167387,0.00039634458,0.029888308],"study_design_scores_gemma":[0.00023674175,0.0076194997,0.0069279084,0.000010825476,0.00009338657,0.00068854267,0.000039622802,0.0031762272,0.9727769,0.00008352529,0.008332099,0.000014760266],"about_ca_topic_score_codex":0.00044206125,"about_ca_topic_score_gemma":0.0015663644,"teacher_disagreement_score":0.0011310326,"about_ca_system_score_codex":0.0001269263,"about_ca_system_score_gemma":0.00016816924,"threshold_uncertainty_score":0.0037836432},"labels":[],"label_agreement":null},{"id":"W4308976883","doi":"10.1093/neuonc/noac209.135","title":"STEM-18. EPIGENETIC AND MOLECULAR COORDINATION BETWEEN HDAC2 AND SMAD3-SKI IS REQUIRED FOR GROWTH AND STEM CELL CHARACTERISTICS OF BRAIN TUMOUR STEM CELLS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Neurosciences, Mental Health and Addiction; Government of Canada; University of Calgary","funders":"","keywords":"Epigenetics; Biology; Stem cell; Chromatin; Cancer stem cell; Neural stem cell; Cancer research; Cell growth; Cell biology; Genetics","score_opus":0.019614621106355354,"score_gpt":0.27745685641914053,"score_spread":0.25784223531278516,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4308976883","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97899663,0.0026324491,0.009878235,0.00025551912,0.00012236885,0.000057884146,0.0028302306,0.0004775643,0.0047491393],"genre_scores_gemma":[0.9892998,0.0005522808,0.0018558189,0.00008534381,0.000013659085,0.00003884393,0.0025542006,0.000053856886,0.0055461875],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998628,0.000010299654,0.0000149671405,0.00003629747,0.00004949339,0.00002609636],"domain_scores_gemma":[0.9998925,0.0000058694336,0.000040667877,0.000009691412,0.000012192675,0.000039186045],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101145175,0.00031178122,0.0002603713,0.00019748136,0.00018788931,0.00034750445,0.00020955896,0.00020793166,0.002880358],"category_scores_gemma":[0.000069367015,0.00018626821,0.00036855976,0.00013101693,0.000218439,0.00014383119,0.0002427477,0.00037275316,0.0009653961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000056705165,0.0000102981685,0.0004379473,0.000037178084,0.0000058214846,0.00005811741,0.000010029543,0.000034944867,0.9981458,0.00012813022,0.00007229622,0.0010027118],"study_design_scores_gemma":[0.000015441854,0.0001003244,0.011340433,0.0000067361784,0.000020311043,0.00034359162,0.000029357896,0.00092357094,0.9805726,0.00005061659,0.006593182,0.0000038282883],"about_ca_topic_score_codex":0.0008405517,"about_ca_topic_score_gemma":0.0020061887,"teacher_disagreement_score":0.002880358,"about_ca_system_score_codex":0.0003528252,"about_ca_system_score_gemma":0.00034683855,"threshold_uncertainty_score":0.009635806},"labels":[],"label_agreement":null},{"id":"W4313359446","doi":"10.4049/jimmunol.200.supp.56.27","title":"Profiling the effects of carbonic anhydrase 9/12 inhibition on tumor associated macrophage/microglia polarization in glioma","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Occupational Cancer Research Centre","funders":"","keywords":"Glioma; Microglia; Temozolomide; Cancer research; Brain tumor; Hypoxia (environmental); Transcriptome; Biology; Tumor hypoxia; Tumor microenvironment; In vivo; Phenotype; Radiation therapy; Gene expression; Immunology; Pathology; Medicine; Chemistry; Gene; Internal medicine; Tumor cells; Inflammation; Biochemistry","score_opus":0.005067713818708041,"score_gpt":0.24724056350344034,"score_spread":0.2421728496847323,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4313359446","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9894973,0.0037272694,0.003161979,0.00011446677,0.00003624955,0.000059139576,0.0021431213,0.00012291213,0.0011375896],"genre_scores_gemma":[0.9907526,0.0022964254,0.003341295,0.00011136907,0.000013491055,0.00009190967,0.001774502,0.000025334984,0.0015931727],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991226,0.000008167284,0.0000051351694,0.000015943213,0.000032757896,0.000025715939],"domain_scores_gemma":[0.99995995,0.0000044232224,0.0000103880975,0.0000031009688,0.000011579448,0.000010634059],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008984257,0.00019374503,0.00031758478,0.00022311026,0.00013803712,0.00026833493,0.00009818897,0.00016677995,0.00059597596],"category_scores_gemma":[0.000060757688,0.00007472485,0.00018902747,0.00024212617,0.000106342944,0.00010527546,0.00009490711,0.0003185269,0.00019442031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002746002,0.000038148595,0.000729572,0.00007448355,0.000010639601,0.000018802491,0.000011466198,0.00013039261,0.9950989,0.000022018385,0.000104650586,0.003486304],"study_design_scores_gemma":[0.000018481953,0.000738384,0.026551327,0.000011118754,0.00005627651,0.00017072917,0.00008353895,0.0021413837,0.9664792,0.00008562447,0.0036542413,0.000009817367],"about_ca_topic_score_codex":0.00058622006,"about_ca_topic_score_gemma":0.0014205024,"teacher_disagreement_score":0.00059597596,"about_ca_system_score_codex":0.00017854298,"about_ca_system_score_gemma":0.00021684902,"threshold_uncertainty_score":0.0019937754},"labels":[],"label_agreement":null},{"id":"W4313829039","doi":"10.3390/biomedicines11010169","title":"Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Laurentian University","funders":"","keywords":"Epigenetics; Immunotherapy; Immune system; Carcinogenesis; Epigenetic therapy; Cancer; Cancer immunotherapy; Medicine; Cancer research; Epigenesis; Immunology; Bioinformatics; Biology; DNA methylation; Genetics; Internal medicine; Gene expression; Gene","score_opus":0.06545465584488153,"score_gpt":0.4120408639443578,"score_spread":0.34658620809947627,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4313829039","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00018190878,0.9957216,0.00042669894,0.0014170934,0.0005324797,0.000005315862,0.000019518782,0.000016116677,0.0016792283],"genre_scores_gemma":[0.0014868381,0.9952793,0.00040377406,0.0007976388,0.00045486007,0.00000930026,0.00003757188,0.000003387363,0.0015274334],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99986315,0.000028337392,0.00001169495,0.000023240049,0.00005385642,0.000019643232],"domain_scores_gemma":[0.99982077,0.00008346121,0.000016038372,0.00000778524,0.00004713162,0.000024863779],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005070072,0.00056918943,0.0008656048,0.001211895,0.00028593527,0.00090700586,0.0005897827,0.001184717,0.00442234],"category_scores_gemma":[0.00042454895,0.00020589234,0.00042737063,0.000943377,0.00058785075,0.0015306438,0.00068155525,0.0026155505,0.0022830693],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000092000235,0.00009753919,0.0001972173,0.009049659,0.00007575589,0.0003051059,0.000086020584,0.0003864505,0.009509632,0.017226854,0.0511227,0.9118511],"study_design_scores_gemma":[0.00001396168,0.00008028173,0.00031630363,0.00093731435,0.000038125036,0.00063626026,0.000038259986,0.000096517404,0.0011962467,0.0041059973,0.9925288,0.000011975829],"about_ca_topic_score_codex":0.00047953601,"about_ca_topic_score_gemma":0.0012354802,"teacher_disagreement_score":0.00442234,"about_ca_system_score_codex":0.0007158813,"about_ca_system_score_gemma":0.0009034627,"threshold_uncertainty_score":0.014794171},"labels":[],"label_agreement":null},{"id":"W4321482216","doi":"10.1101/2023.02.21.525740","title":"Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Genentech; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Office of Research Infrastructure Programs, National Institutes of Health; Genome Canada; Argonne National Laboratory; U.S. Department of Energy; McGill University; Office of Science; Austrian Science Fund; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"HDAC6; Chemistry; Ubiquitin; Zinc finger; Cell biology; Small molecule; Ubiquitin ligase; Drug discovery; Histone deacetylase; Computational biology; Biochemistry; Biophysics; Cancer research; Histone; Biology; Gene","score_opus":0.012063176135429681,"score_gpt":0.23456639553780248,"score_spread":0.2225032194023728,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4321482216","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97251105,0.0018169546,0.021096403,0.00018923677,0.00003408369,0.0001697343,0.0010905402,0.0001011177,0.00299089],"genre_scores_gemma":[0.9760953,0.0007963622,0.017324759,0.00011223123,0.000012059518,0.00009085807,0.0014522348,0.000026172964,0.004090058],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998951,0.000017601422,0.0000051685106,0.000022929406,0.000035346035,0.000023862558],"domain_scores_gemma":[0.9999236,0.000014867013,0.000016900505,0.000008065991,0.000011461974,0.000025123583],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027255944,0.00032346701,0.00021822687,0.00016755573,0.00014093051,0.00019358512,0.0003026564,0.00038234802,0.0011840668],"category_scores_gemma":[0.00018569296,0.00010770526,0.00027750368,0.00013547299,0.0002282985,0.00011993639,0.00014962352,0.00035706116,0.00045738308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000030751533,0.00001327071,0.00006377423,0.000014864304,0.0000030591784,0.000018544924,0.0000053057856,0.00015037878,0.99880934,0.000080748374,0.000031574087,0.0007784956],"study_design_scores_gemma":[0.000011137107,0.00017987484,0.00037186415,0.0000015125775,0.0000051420693,0.000055890003,0.0000050425306,0.00047229204,0.9973464,0.000017333725,0.001531124,0.0000023688315],"about_ca_topic_score_codex":0.0010774143,"about_ca_topic_score_gemma":0.0010041642,"teacher_disagreement_score":0.0011840668,"about_ca_system_score_codex":0.0004262544,"about_ca_system_score_gemma":0.000262511,"threshold_uncertainty_score":0.003961146},"labels":[],"label_agreement":null},{"id":"W4322212953","doi":"10.14740/wjon1571","title":"The Impact of DTYMK as a Prognostic Marker in Colorectal Cancer","year":2023,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Medicine; Colorectal cancer; Tissue microarray; Immunohistochemistry; Biomarker; MSH2; Internal medicine; Oncology; Clinical significance; Hepatocellular carcinoma; Stage (stratigraphy); MSH6; Adenocarcinoma; Lung cancer; Cancer; Pathological; Pathology; Biology","score_opus":0.015812199659635384,"score_gpt":0.38083693360649484,"score_spread":0.36502473394685947,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4322212953","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99245983,0.005219561,0.00038530477,0.00012924205,0.000020770434,0.0000073961787,0.0010187362,0.000021076225,0.0007380351],"genre_scores_gemma":[0.99785835,0.00070929097,0.0004789043,0.000014957404,0.00002071422,0.0000041522385,0.00079078693,0.0000028342497,0.00012004529],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.999777,0.00004812364,0.000033012177,0.000048960505,0.000060184957,0.000032646814],"domain_scores_gemma":[0.999218,0.00020051027,0.0003414142,0.00003389806,0.00008622335,0.00012001515],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042257996,0.00022969674,0.0002782325,0.0009309049,0.00021453724,0.000570865,0.00015857483,0.00017652685,0.00089917524],"category_scores_gemma":[0.0011881301,0.00007972089,0.00019692404,0.001430122,0.00015093223,0.0002686818,0.00030679425,0.00022377155,0.00021704864],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008903514,0.000023067685,0.97921306,0.00009638651,0.00007914004,0.00016533716,0.000018186418,0.0002730596,0.00428482,0.000026704962,0.0002651849,0.0146646025],"study_design_scores_gemma":[0.000016877308,0.00023665595,0.9917105,0.00002118074,0.00016786238,0.0010672502,0.00006177091,0.0020550184,0.0028071874,0.00011360639,0.0017327789,0.000009251829],"about_ca_topic_score_codex":0.00092537387,"about_ca_topic_score_gemma":0.0017276207,"teacher_disagreement_score":0.0009309049,"about_ca_system_score_codex":0.00030283362,"about_ca_system_score_gemma":0.00023770166,"threshold_uncertainty_score":0.003008008},"labels":[],"label_agreement":null},{"id":"W4322496222","doi":"10.1080/10408363.2023.2177251","title":"Histone deacetylase inhibitors as a potential new treatment for psoriatic disease and other inflammatory conditions","year":2023,"lang":"en","type":"review","venue":"Critical Reviews in Clinical Laboratory Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland; University Health Network; University of Toronto","funders":"","keywords":"Psoriasis; Psoriatic arthritis; Medicine; Rheumatoid arthritis; Histone deacetylase; Disease; Immunology; Inflammation; Population; Internal medicine; Histone; Biology","score_opus":0.1714815792163335,"score_gpt":0.5364963431777438,"score_spread":0.36501476396141025,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4322496222","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00014039603,0.998221,0.00011225653,0.0002648206,0.00024566407,0.0000060822963,0.000021188685,0.000009567683,0.0009789881],"genre_scores_gemma":[0.0009117874,0.9976318,0.0001822216,0.00029612993,0.00019177786,0.000008583729,0.00003964287,0.0000017587047,0.0007363142],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99983704,0.000032086158,0.000020802401,0.000029009936,0.00006400762,0.000016999908],"domain_scores_gemma":[0.99984884,0.000071395676,0.000020993433,0.0000045115107,0.000036865742,0.000017472752],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035537136,0.0006328778,0.0010387868,0.0016495452,0.00023454269,0.0006791079,0.0006065978,0.00090364093,0.0050642733],"category_scores_gemma":[0.00047277464,0.00017249161,0.00057962857,0.0010817678,0.0002732294,0.00078213,0.00040837252,0.0020333398,0.0018974717],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013560905,0.00012961755,0.00012262806,0.017389596,0.0001299511,0.00026342578,0.000059150396,0.0003170306,0.0037014068,0.0036586712,0.040603828,0.933489],"study_design_scores_gemma":[0.00004910257,0.00018523588,0.00069228065,0.0028176606,0.00016072055,0.0012889121,0.000041187308,0.00010015711,0.0007273473,0.0016405984,0.99227977,0.000017032333],"about_ca_topic_score_codex":0.0006745112,"about_ca_topic_score_gemma":0.0018728711,"teacher_disagreement_score":0.0050642733,"about_ca_system_score_codex":0.00041706424,"about_ca_system_score_gemma":0.0006443236,"threshold_uncertainty_score":0.016941726},"labels":[],"label_agreement":null},{"id":"W4323349721","doi":"10.1016/j.canlet.2023.216121","title":"The impact of histone deacetylase inhibitors on immune cells and implications for cancer therapy","year":2023,"lang":"en","type":"review","venue":"Cancer Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Trinity College","funders":"","keywords":"Histone deacetylase; Immune system; Cancer research; Context (archaeology); Immunotherapy; Epigenetic therapy; Cancer; Biology; Histone deacetylase inhibitor; Vorinostat; Immunology; Epigenetics; Medicine; Histone; DNA methylation; DNA","score_opus":0.056385053863070154,"score_gpt":0.44074457955738333,"score_spread":0.3843595256943132,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4323349721","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009319858,0.997964,0.00008347386,0.00046917767,0.0003907227,0.0000031923025,0.000013484092,0.0000065082113,0.00097630156],"genre_scores_gemma":[0.0005151218,0.9981072,0.00009977158,0.00034981946,0.00021928982,0.000005098291,0.00002016246,0.0000013491591,0.0006821883],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998135,0.000033618762,0.000020890857,0.000028999959,0.00008193215,0.00002122158],"domain_scores_gemma":[0.9997341,0.000124699,0.000027726284,0.000009134609,0.00007722649,0.000027008406],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005664658,0.0006497177,0.001018581,0.0014858957,0.00023074728,0.000742024,0.00069966255,0.0010430585,0.0032191346],"category_scores_gemma":[0.0006961899,0.00025242032,0.0004944199,0.0014689994,0.00048052252,0.0010255831,0.00048756984,0.0022815156,0.0022375698],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001197485,0.00007108436,0.000112533126,0.009975385,0.00008759743,0.00019090189,0.000048834656,0.00049089437,0.0026078653,0.005596399,0.06470113,0.9159976],"study_design_scores_gemma":[0.000026245441,0.000096385105,0.0004535134,0.0015399249,0.00005119951,0.00065819354,0.000025830781,0.00007362963,0.00039884617,0.0017446765,0.9949196,0.000011822212],"about_ca_topic_score_codex":0.00090594013,"about_ca_topic_score_gemma":0.0020918516,"teacher_disagreement_score":0.0032191346,"about_ca_system_score_codex":0.0008337283,"about_ca_system_score_gemma":0.0007992099,"threshold_uncertainty_score":0.010769069},"labels":[],"label_agreement":null},{"id":"W4360602626","doi":"10.1016/j.bbrc.2023.03.031","title":"Phenylbutyric acid robustly increases Npy mRNA expression in hypothalamic neurons by increasing H3K9/14 acetylation at the Npy promoter","year":2023,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Orexigenic; Neuropeptide Y receptor; Endocrinology; Internal medicine; Histone deacetylase inhibitor; Histone deacetylase; Chemistry; Acetylation; Biology; Histone; Receptor; Neuropeptide; Medicine; Biochemistry","score_opus":0.04926668452607117,"score_gpt":0.3466162698524097,"score_spread":0.2973495853263385,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4360602626","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9932405,0.0014151164,0.00178427,0.0003673337,0.0001452673,0.00002136237,0.0010546583,0.000093498515,0.0018780028],"genre_scores_gemma":[0.9890526,0.0011871124,0.0027030127,0.00021848202,0.000049845068,0.00006075202,0.0011638136,0.00007293378,0.0054915426],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998338,0.000011424159,0.000012739965,0.00004368366,0.000036470883,0.00006181193],"domain_scores_gemma":[0.999858,0.00002824096,0.000026387286,0.000021632268,0.000013543481,0.000052146675],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115964336,0.00034229524,0.0003391115,0.00020664954,0.00029685235,0.00035702577,0.00023852762,0.00025234066,0.002461763],"category_scores_gemma":[0.00015294703,0.00027465465,0.0003555991,0.00020373658,0.00048061303,0.00024885402,0.0003046098,0.001037469,0.00042908348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038242218,0.000021835584,0.00014342494,0.000017898265,0.00000584953,0.000030283834,0.000009168735,0.000033000004,0.99862134,0.000027966438,0.00004343523,0.0006634012],"study_design_scores_gemma":[0.000042535776,0.00028573745,0.008521979,0.000006565982,0.000014312047,0.000059824182,0.00005735535,0.00025062304,0.9898878,0.000057312755,0.000811626,0.0000044496005],"about_ca_topic_score_codex":0.0037879113,"about_ca_topic_score_gemma":0.010939309,"teacher_disagreement_score":0.0037879113,"about_ca_system_score_codex":0.000738809,"about_ca_system_score_gemma":0.00047669734,"threshold_uncertainty_score":0.008235395},"labels":[],"label_agreement":null},{"id":"W4360990755","doi":"10.1016/j.pdpdt.2023.103374","title":"LXD191 is a novel, triple-action photosensitiser-histone deacetylase targeting inhibitor drug-drug conjugate: efficient and selective killing of human oral cancer cells and animal tissue upon irradiation","year":2023,"lang":"en","type":"article","venue":"Photodiagnosis and Photodynamic Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Nexen (Canada)","funders":"","keywords":"Histone deacetylase; Cancer research; Cancer cell; Programmed cell death; Pharmacology; Vorinostat; Chemistry; Histone deacetylase inhibitor; Cell growth; Biology; Cancer; Apoptosis; Biochemistry; Histone","score_opus":0.016816503301025344,"score_gpt":0.3212843411830369,"score_spread":0.30446783788201154,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4360990755","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96869004,0.005126077,0.018462116,0.0003224046,0.00008323889,0.00018206447,0.00062741566,0.00051337655,0.0059932233],"genre_scores_gemma":[0.986429,0.0013922893,0.0057989378,0.00006809011,0.000010670115,0.000049429622,0.0006759016,0.00004042065,0.0055353143],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992955,0.000009233844,0.00000445709,0.000023804554,0.0000166826,0.000016321546],"domain_scores_gemma":[0.9999678,0.0000037084733,0.000011440062,0.0000029436208,0.0000029322564,0.000011123335],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012402132,0.0004150498,0.00028312358,0.00023360022,0.00015201245,0.0002324314,0.00028054003,0.00030564892,0.0011626092],"category_scores_gemma":[0.000065627086,0.00017943146,0.00015779457,0.00015314856,0.0001762218,0.00022055274,0.00024650415,0.00036442396,0.00046980224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014012064,0.000049993487,0.0001575563,0.000048194728,0.000006177326,0.0000715813,0.000011435872,0.00009892916,0.9930038,0.00021269685,0.00018358519,0.0060159885],"study_design_scores_gemma":[0.000023727807,0.00030727492,0.0005766501,0.0000017505293,0.0000092631,0.0003174991,0.0000037273144,0.0003075297,0.99526393,0.000014622796,0.0031707291,0.0000033412384],"about_ca_topic_score_codex":0.00033729267,"about_ca_topic_score_gemma":0.00049530645,"teacher_disagreement_score":0.0011626092,"about_ca_system_score_codex":0.00041059524,"about_ca_system_score_gemma":0.00019138695,"threshold_uncertainty_score":0.0038893223},"labels":[],"label_agreement":null},{"id":"W4361822828","doi":"10.1158/0008-5472.c.6499386.v1","title":"Data from PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A–Mediated Inactivation in Human Malignant Glioma","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Pirkanmaan Sairaanhoitopiiri; Emil Aaltosen Säätiö; Helsingin ja Uudenmaan Sairaanhoitopiiri; Damon Runyon Cancer Research Foundation","keywords":"MAPK/ERK pathway; Kinase; Signal transduction; Phosphatase; Protein kinase A; Protein phosphatase 1; c-Raf; Cancer research; Cell biology; Biology; Protein phosphatase 2; Phosphorylation; Chemistry; Mitogen-activated protein kinase kinase; Molecular biology","score_opus":0.05559027444916049,"score_gpt":0.30450370707816715,"score_spread":0.24891343262900667,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4361822828","genre_codex":"empirical","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9831314,0.005212907,0.0032271282,0.0004410595,0.00007997725,0.00008487253,0.003095125,0.00019928628,0.004528353],"genre_scores_gemma":[0.97746116,0.0036120443,0.0027447357,0.00013770087,0.000023827579,0.00017410691,0.009894193,0.00004502544,0.0059072557],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998265,0.000040172083,0.00001916553,0.000021336737,0.000056630164,0.000036244335],"domain_scores_gemma":[0.99991715,0.000016698212,0.000012076395,0.000017929642,0.000012310013,0.00002394049],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021757616,0.00055988086,0.0003857437,0.0004874634,0.00022556983,0.00021206746,0.00024179788,0.00027903612,0.002799967],"category_scores_gemma":[0.00013786467,0.00018846526,0.0004899921,0.00030688813,0.00022376813,0.00017791656,0.00017261534,0.0007465179,0.0009270466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009498351,0.0003124014,0.0003748177,0.00015314526,0.000029340692,0.00012516086,0.000031366613,0.0002121854,0.99247134,0.00017514022,0.0005416691,0.0046236226],"study_design_scores_gemma":[0.00009333709,0.0013175714,0.008376575,0.0000059518707,0.000039746305,0.0004915193,0.000027295102,0.00069972686,0.98412675,0.000068714246,0.0047456915,0.000007001136],"about_ca_topic_score_codex":0.0014676669,"about_ca_topic_score_gemma":0.0014319379,"teacher_disagreement_score":0.002799967,"about_ca_system_score_codex":0.00032676145,"about_ca_system_score_gemma":0.00024188342,"threshold_uncertainty_score":0.00936681},"labels":[],"label_agreement":null},{"id":"W4361823512","doi":"10.1158/0008-5472.c.6503036.v1","title":"Data from Resuscitating Cancer Immunosurveillance: Selective Stimulation of DLL1-Notch Signaling in T cells Rescues T-cell Function and Inhibits Tumor Growth","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Genentech; University of Toronto; University of Pennsylvania; Vanderbilt University","keywords":"Immunosurveillance; Immunoediting; Immune system; Cancer research; T cell; Cell biology; Cancer; Signal transduction; Tumor microenvironment; Biology; Cell growth; Notch signaling pathway; Chemistry; Immunology; Immunotherapy; Biochemistry; Genetics","score_opus":0.0460886906860978,"score_gpt":0.32367277352956547,"score_spread":0.2775840828434677,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4361823512","genre_codex":"empirical","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8188467,0.017103063,0.020649487,0.005626353,0.002115681,0.00033331427,0.027277894,0.002146614,0.105900854],"genre_scores_gemma":[0.8877484,0.0075590005,0.008137859,0.0014457541,0.00018779316,0.00024387237,0.021790497,0.000320273,0.07256658],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.99969494,0.000036537596,0.000037865542,0.000050141454,0.000118583055,0.00006192617],"domain_scores_gemma":[0.9998104,0.00004740566,0.000016485066,0.000034834076,0.000033489254,0.00005749311],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003120783,0.0007460045,0.0006199955,0.0005163213,0.00025339425,0.0005846357,0.0004614211,0.00045750733,0.011590449],"category_scores_gemma":[0.00021227726,0.00014339312,0.0005379538,0.00030247585,0.0003525001,0.00025045025,0.0002595274,0.0017811381,0.0036392496],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0029162576,0.0008652179,0.00086234906,0.00048653354,0.00010756346,0.0005088811,0.00007584074,0.00080973166,0.9542492,0.0018926881,0.010228112,0.026997628],"study_design_scores_gemma":[0.00016075774,0.00065817585,0.002743624,0.000014558397,0.000055110588,0.00038534592,0.000031983134,0.00094981404,0.965939,0.00022458106,0.028827721,0.000009401562],"about_ca_topic_score_codex":0.0018102609,"about_ca_topic_score_gemma":0.00141065,"teacher_disagreement_score":0.011590449,"about_ca_system_score_codex":0.00054185744,"about_ca_system_score_gemma":0.00039079695,"threshold_uncertainty_score":0.038773894},"labels":[],"label_agreement":null},{"id":"W4362546372","doi":"10.1158/2159-8290.c.6549562.v1","title":"Data from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Health and Medical Research Council; Peter MacCallum Cancer Centre; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canada Research Chairs; Cancer Council Victoria; Deutsche Forschungsgemeinschaft; Cancer Australia; Australian Cancer Research Foundation; Medical Research Council; Kids' Cancer Project; Marshfield Clinic Research Foundation","keywords":"Panobinostat; Epigenetics; Cancer research; Myeloid leukemia; Leukemia; Biology; Myeloid; Immunology; Histone deacetylase; Histone; Gene; Genetics","score_opus":0.07812436539701738,"score_gpt":0.34105130137837075,"score_spread":0.26292693598135336,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4362546372","genre_codex":"empirical","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.938669,0.0037888507,0.015011364,0.0020181926,0.00037550763,0.00031183925,0.012248985,0.0009099552,0.02666621],"genre_scores_gemma":[0.97593176,0.0010509688,0.0043807453,0.0005706672,0.000049504804,0.00019168243,0.004291845,0.00011976239,0.013412932],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996903,0.0000337001,0.000038027385,0.00006870481,0.00011702462,0.000052304764],"domain_scores_gemma":[0.9998503,0.000025943029,0.00002837072,0.000028570881,0.000025988124,0.0000408582],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020512186,0.0002321459,0.0002928324,0.00033343927,0.00021521376,0.00045169907,0.00022109489,0.00040832988,0.011252792],"category_scores_gemma":[0.00014834882,0.00016548716,0.0003083451,0.00020532518,0.00031992473,0.00025150192,0.00028670425,0.0016316792,0.0022777263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004611819,0.00010543474,0.0003296877,0.00008630095,0.000010233397,0.00007958602,0.00003060482,0.000094389856,0.99107075,0.00055621995,0.0005982021,0.0065772966],"study_design_scores_gemma":[0.00008483304,0.0003762306,0.0073887515,0.000012370089,0.00002395899,0.0003025503,0.0000542863,0.0007744704,0.97486115,0.00020490876,0.015910467,0.0000060352404],"about_ca_topic_score_codex":0.00032979535,"about_ca_topic_score_gemma":0.0006511711,"teacher_disagreement_score":0.011252792,"about_ca_system_score_codex":0.00045410809,"about_ca_system_score_gemma":0.00029198962,"threshold_uncertainty_score":0.037644327},"labels":[],"label_agreement":null},{"id":"W4362556152","doi":"10.1158/2159-8290.c.6549562","title":"Data from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Panobinostat; Epigenetics; Cancer research; Myeloid leukemia; Leukemia; Biology; Myeloid; Epigenetic therapy; Histone deacetylase; Immunology; Histone; Gene; DNA methylation; Gene expression; Genetics","score_opus":0.07812436539701738,"score_gpt":0.34105130137837075,"score_spread":0.26292693598135336,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4362556152","genre_codex":"empirical","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.938669,0.0037888507,0.015011364,0.0020181926,0.00037550763,0.00031183925,0.012248985,0.0009099552,0.02666621],"genre_scores_gemma":[0.97593176,0.0010509688,0.0043807453,0.0005706672,0.000049504804,0.00019168243,0.004291845,0.00011976239,0.013412932],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9996903,0.0000337001,0.000038027385,0.00006870481,0.00011702462,0.000052304764],"domain_scores_gemma":[0.9998503,0.000025943029,0.00002837072,0.000028570881,0.000025988124,0.0000408582],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020512186,0.0002321459,0.0002928324,0.00033343927,0.00021521376,0.00045169907,0.00022109489,0.00040832988,0.011252792],"category_scores_gemma":[0.00014834882,0.00016548716,0.0003083451,0.00020532518,0.00031992473,0.00025150192,0.00028670425,0.0016316792,0.0022777263],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004611819,0.00010543474,0.0003296877,0.00008630095,0.000010233397,0.00007958602,0.00003060482,0.000094389856,0.99107075,0.00055621995,0.0005982021,0.0065772966],"study_design_scores_gemma":[0.00008483304,0.0003762306,0.0073887515,0.000012370089,0.00002395899,0.0003025503,0.0000542863,0.0007744704,0.97486115,0.00020490876,0.015910467,0.0000060352404],"about_ca_topic_score_codex":0.00032979535,"about_ca_topic_score_gemma":0.0006511711,"teacher_disagreement_score":0.011252792,"about_ca_system_score_codex":0.00045410809,"about_ca_system_score_gemma":0.00029198962,"threshold_uncertainty_score":0.037644327},"labels":[],"label_agreement":null},{"id":"W4379058175","doi":"10.1016/j.celrep.2023.112583","title":"Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Cell biology; Pyruvate dehydrogenase complex; Chromatin remodeling; Histone; Acetyl-CoA; P300-CBP Transcription Factors; Pyruvate dehydrogenase kinase; Chemistry; Biology; Histone acetyltransferase; T cell; Biochemistry; Metabolism; Histone Acetyltransferases; Enzyme; Gene; Immunology","score_opus":0.010128579930321768,"score_gpt":0.2527605185607754,"score_spread":0.24263193863045365,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4379058175","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99058354,0.0025937967,0.003446058,0.00013670296,0.000046156554,0.0000197355,0.00055478077,0.00008499096,0.0025341297],"genre_scores_gemma":[0.9964741,0.0005113932,0.0009628429,0.00003481203,0.0000092288265,0.000010516178,0.00037426993,0.000015502572,0.0016072966],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987876,0.000020068985,0.0000057376237,0.000041056777,0.00001826478,0.000036089496],"domain_scores_gemma":[0.9999379,0.00000793916,0.000020530257,0.0000052885603,0.0000094824045,0.000018861952],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010161511,0.00016809533,0.000108648186,0.00014746649,0.00018192166,0.00046784908,0.00012467036,0.00018566444,0.0016355601],"category_scores_gemma":[0.00011828984,0.00013155698,0.00011417572,0.00014705899,0.00020587348,0.00023607413,0.00022608445,0.00023055925,0.00050784054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021313115,0.000009173367,0.0009004862,0.000019100771,0.0000028226675,0.000042551415,0.00002389045,0.00007744405,0.99652135,0.00013120327,0.00004930433,0.0020095438],"study_design_scores_gemma":[0.000027702989,0.00016200078,0.0311625,0.000007614654,0.000012407529,0.00020673634,0.00010299155,0.0012384701,0.96225464,0.0002613138,0.004554989,0.000008569742],"about_ca_topic_score_codex":0.0004491193,"about_ca_topic_score_gemma":0.00090520806,"teacher_disagreement_score":0.0016355601,"about_ca_system_score_codex":0.00033548122,"about_ca_system_score_gemma":0.00017509541,"threshold_uncertainty_score":0.005471468},"labels":[],"label_agreement":null},{"id":"W4384007311","doi":"10.1016/j.ejcb.2023.151341","title":"ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat","year":2023,"lang":"en","type":"article","venue":"European Journal of Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Science Fund for Distinguished Young Scholars; China National Funds for Distinguished Young Scientists; National Natural Science Foundation of China; Harbin Medical University; Cancer Research Society; Canadian Institutes of Health Research; Natural Science Foundation of Heilongjiang Province","keywords":"Vorinostat; Cancer research; Histone deacetylase; Chromatin remodeling; Gene knockdown; Biology; Histone deacetylase inhibitor; Chromatin; Cell biology; Histone; Cell culture; Genetics","score_opus":0.011345312080098473,"score_gpt":0.26546934831601365,"score_spread":0.2541240362359152,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4384007311","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98803407,0.0027680316,0.0016000441,0.00044600756,0.0001168502,0.00006922286,0.0010287943,0.0002557818,0.005681225],"genre_scores_gemma":[0.99234784,0.0018606156,0.0010424847,0.00010923635,0.00002109317,0.00006531988,0.0013625717,0.000023771594,0.0031670262],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999194,0.00001125802,0.0000072838448,0.000008837129,0.00001819969,0.000034971825],"domain_scores_gemma":[0.9999666,0.000005403267,0.000007923148,0.000003299255,0.000003944449,0.000012920888],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009202276,0.00027180454,0.00027071108,0.00024747013,0.00013095349,0.00016255557,0.0001577234,0.00012801087,0.002136874],"category_scores_gemma":[0.000062952146,0.00011530903,0.00028062027,0.00015563605,0.0001584495,0.00011199836,0.000102960745,0.00061611336,0.00034817215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007466861,0.00019102525,0.00031442428,0.000130916,0.00002053374,0.00008028452,0.00002227737,0.0003136947,0.9916161,0.00020088066,0.0006941095,0.00566908],"study_design_scores_gemma":[0.00018718379,0.001576599,0.0062181703,0.000010925651,0.000048079193,0.00027188318,0.000042570588,0.0016641099,0.98209053,0.000078092125,0.0078034513,0.000008321323],"about_ca_topic_score_codex":0.0007246289,"about_ca_topic_score_gemma":0.0027845015,"teacher_disagreement_score":0.002136874,"about_ca_system_score_codex":0.000268843,"about_ca_system_score_gemma":0.00026076782,"threshold_uncertainty_score":0.0071486235},"labels":[],"label_agreement":null},{"id":"W4385323638","doi":"10.1021/acs.jmedchem.3c00314","title":"Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Genentech; Ontario Genomics Institute; Takeda Pharmaceutical Company; European Federation of Pharmaceutical Industries and Associations; Structural Genomics Consortium; Janssen Pharmaceuticals; Merck KGaA; National Institutes of Health; Ontario Genomics; Office of Research Infrastructure Programs, National Institutes of Health; Genome Canada; Bayer; Pfizer; Bristol-Myers Squibb; McGill University; Office of Science; Austrian Science Fund; Boehringer Ingelheim; Argonne National Laboratory; U.S. Department of Energy","keywords":"HDAC6; Chemistry; Ubiquitin; Small molecule; Zinc finger; Cell biology; Drug discovery; Ubiquitin ligase; In vitro; Histone deacetylase; Biochemistry; Computational biology; Histone; Biology; Gene","score_opus":0.009124392131888431,"score_gpt":0.26472632057765827,"score_spread":0.25560192844576984,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385323638","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95682484,0.0021964288,0.03509779,0.00029255945,0.000033543336,0.00027591403,0.001182564,0.0001575189,0.003938756],"genre_scores_gemma":[0.96645045,0.001302864,0.025830114,0.00017152965,0.0000168615,0.00012612595,0.0016239303,0.000032442465,0.0044456986],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989593,0.000016166256,0.00000476303,0.000022631752,0.00003654731,0.000023941902],"domain_scores_gemma":[0.99992955,0.000014063331,0.000016449965,0.0000068107593,0.0000114737995,0.000021672724],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002388831,0.00034500312,0.00022300179,0.00016478317,0.00013606552,0.00018631884,0.00035425732,0.0004877158,0.0011476108],"category_scores_gemma":[0.00019096042,0.00011590641,0.0002894883,0.0001352141,0.00020822749,0.00014621725,0.00013439464,0.00038530253,0.0004681152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000025680374,0.000015720509,0.000041436397,0.000016280279,0.0000027931383,0.00002082637,0.000005768226,0.00015501564,0.99863595,0.00007990556,0.000036437992,0.0009641935],"study_design_scores_gemma":[0.0000111111,0.00021623641,0.0003722679,0.0000015430523,0.000005162379,0.0000748193,0.000005852537,0.000579857,0.996995,0.0000150767355,0.00172024,0.0000030438232],"about_ca_topic_score_codex":0.0008743885,"about_ca_topic_score_gemma":0.0010433353,"teacher_disagreement_score":0.0011476108,"about_ca_system_score_codex":0.0004373165,"about_ca_system_score_gemma":0.00023217402,"threshold_uncertainty_score":0.0038390756},"labels":[],"label_agreement":null},{"id":"W4385851206","doi":"10.1002/1878-0261.13508","title":"Canagliflozin mediates tumor suppression alone and in combination with radiotherapy in non‐small cell lung cancer (NSCLC) through inhibition of HIF‐1α","year":2023,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; McGill University; McMaster University Medical Centre; Discovery Centre; Juravinski Cancer Centre","funders":"Diabetes Canada; Canadian Institutes of Health Research; Hamilton Health Sciences","keywords":"Canagliflozin; Cancer research; Biology; PI3K/AKT/mTOR pathway; Gene knockdown; Signal transduction; Apoptosis; Cell biology; Endocrinology; Biochemistry","score_opus":0.007535637932075384,"score_gpt":0.2904041511328334,"score_spread":0.282868513200758,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385851206","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98519135,0.008060121,0.0032509605,0.0002766971,0.00016282541,0.000094986375,0.0005227919,0.00021148946,0.0022288477],"genre_scores_gemma":[0.991839,0.0031001114,0.0023662546,0.00019528555,0.000034081128,0.00010592319,0.0007423498,0.000016806696,0.00160033],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999074,0.000010011738,0.0000075187027,0.000024818548,0.00002810219,0.000022138607],"domain_scores_gemma":[0.9999659,0.0000062122417,0.000010249662,0.0000032263865,0.000005668347,0.0000086557275],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014427789,0.00024906054,0.00035574252,0.00025715033,0.00012586305,0.00021408239,0.00014034181,0.00019014916,0.0006841789],"category_scores_gemma":[0.00008976866,0.00009464023,0.00031268346,0.00017798631,0.0001350909,0.00015830484,0.00009528844,0.00061190693,0.00017711747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010726159,0.000573316,0.0014630221,0.00039759942,0.00007023936,0.000079920654,0.000029595954,0.0006537834,0.96407515,0.00017004533,0.0010065724,0.030408153],"study_design_scores_gemma":[0.0003136407,0.0036309236,0.017333768,0.00002193355,0.0002472905,0.00038998428,0.00003139081,0.0048646983,0.9597888,0.00010319108,0.013259199,0.000015233549],"about_ca_topic_score_codex":0.00068291445,"about_ca_topic_score_gemma":0.0018376741,"teacher_disagreement_score":0.0006841789,"about_ca_system_score_codex":0.00026443618,"about_ca_system_score_gemma":0.00021980537,"threshold_uncertainty_score":0.0022887588},"labels":[],"label_agreement":null},{"id":"W4386001919","doi":"10.1038/s41467-023-40776-y","title":"Epigenetic and molecular coordination between HDAC2 and SMAD3-SKI regulates essential brain tumour stem cell characteristics","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"CIHR Skin Research Training Centre; Government of Canada; University of Calgary; Stand Up To Cancer; Canadian Institutes of Health Research; Genome Canada; American Association for Cancer Research","keywords":"Epigenetics; Chromatin; Histone; Histone deacetylase 2; Histone deacetylase; Biology; Stem cell; Cancer research; Chromatin remodeling; Cell biology; Computational biology; Genetics; DNA; Gene","score_opus":0.01132296876513552,"score_gpt":0.2945347421973188,"score_spread":0.2832117734321833,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386001919","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9835301,0.003369236,0.0070280097,0.00018086209,0.00007881975,0.000027772388,0.0009380881,0.00022733527,0.0046196827],"genre_scores_gemma":[0.9953466,0.00067998987,0.00094794424,0.000049892846,0.000009126319,0.000015772926,0.00052538933,0.00003082519,0.0023943977],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998894,0.000009895939,0.0000071538866,0.000029346156,0.000028177548,0.000036128517],"domain_scores_gemma":[0.9999361,0.000004804785,0.000022986442,0.0000072570633,0.000007898298,0.000020897542],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000099049816,0.00027899008,0.00020977308,0.00019030314,0.00015731815,0.0003586279,0.00020076914,0.00014105192,0.0018410962],"category_scores_gemma":[0.000076620294,0.0001606855,0.00028075624,0.00012686993,0.00029079727,0.00015174379,0.00022134546,0.00039853476,0.0005578572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000118958764,0.000012359713,0.00055969175,0.000029602905,0.000008424116,0.00004178275,0.000009051739,0.0000618786,0.9974922,0.00020965385,0.00007529105,0.0013811103],"study_design_scores_gemma":[0.00002080876,0.00013573961,0.018744165,0.0000050410395,0.000025341014,0.00025248274,0.000051903888,0.0012339264,0.9757957,0.000121883975,0.0036067732,0.0000062786967],"about_ca_topic_score_codex":0.0008117866,"about_ca_topic_score_gemma":0.0025031155,"teacher_disagreement_score":0.0018410962,"about_ca_system_score_codex":0.00036362562,"about_ca_system_score_gemma":0.00033362146,"threshold_uncertainty_score":0.006159067},"labels":[],"label_agreement":null},{"id":"W4386161705","doi":"10.26685/urncst.495","title":"The Therapeutic Potential of HDAC Inhibitors for Dopamine Deficiency in Alzheimer’s Disease: A Research Protocol","year":2023,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Dopamine; Ventral tegmental area; Dopaminergic; Microdialysis; Dopamine transporter; Neurotransmitter; Chemistry; Pharmacology; Neuroscience; Medicine; Biology; Central nervous system","score_opus":0.07673604775130666,"score_gpt":0.4640528874805306,"score_spread":0.3873168397292239,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386161705","genre_codex":"protocol","genre_gemma":"protocol","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"protocol","genre_consensus":"protocol","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.18000238,0.114853084,0.052703377,0.0118960645,0.011963738,0.52792287,0.021816019,0.0014803695,0.077362105],"genre_scores_gemma":[0.09836226,0.11327803,0.06642772,0.006526981,0.0026368683,0.5876004,0.013451334,0.00014322363,0.11157319],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9991242,0.00027125663,0.00011818318,0.00014689661,0.00018221195,0.00015729973],"domain_scores_gemma":[0.9992543,0.00013845698,0.00011077181,0.00011719489,0.00020729583,0.00017199366],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0023259248,0.001624674,0.0017938697,0.0007631425,0.0010581436,0.0010750588,0.001855921,0.0024798587,0.026584221],"category_scores_gemma":[0.001198678,0.000503367,0.0022920575,0.0004728123,0.0005545415,0.0009360642,0.00088489085,0.002768109,0.0046221125],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.08201564,0.02233664,0.0011776297,0.021575207,0.00067994674,0.002006394,0.0005087721,0.002121243,0.3270798,0.016734485,0.096775115,0.42698908],"study_design_scores_gemma":[0.043974664,0.14153667,0.0043486995,0.003704612,0.0016557323,0.002499937,0.00027460087,0.0010772,0.14081952,0.0038015659,0.65610486,0.00020182483],"about_ca_topic_score_codex":0.00070756004,"about_ca_topic_score_gemma":0.002157924,"teacher_disagreement_score":0.026584221,"about_ca_system_score_codex":0.0011874078,"about_ca_system_score_gemma":0.004134127,"threshold_uncertainty_score":0.08893305},"labels":[],"label_agreement":null},{"id":"W4386292835","doi":"10.7717/peerj.15961","title":"Regulation of HDAC11 gene expression in early myogenic differentiation","year":2023,"lang":"en","type":"article","venue":"PeerJ","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Umm Al-Qura University","keywords":"MyoD; HDAC11; Myogenesis; Biology; MYF5; HDAC4; Histone; Cellular differentiation; Regulation of gene expression; Histone acetyltransferase; Cell biology; Histone deacetylase; Histone deacetylase 5; Myogenic regulatory factors; Gene expression; Myocyte; Genetics; Gene","score_opus":0.01406658310195169,"score_gpt":0.2757291197319353,"score_spread":0.2616625366299836,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386292835","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93257123,0.015892658,0.023576818,0.00045366804,0.00036802454,0.00014294888,0.0035685014,0.00048448442,0.022941684],"genre_scores_gemma":[0.9659325,0.0049902406,0.0067618117,0.00018744472,0.00005459964,0.00006753502,0.002401885,0.0001136437,0.019490367],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997472,0.00002240613,0.000018180719,0.000083028455,0.00006370318,0.00006529519],"domain_scores_gemma":[0.9998808,0.00001468906,0.000023549643,0.000013153458,0.00003298162,0.000034707733],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017926334,0.00031101142,0.000306834,0.00033374774,0.0003561141,0.0005389477,0.00023247793,0.00028176128,0.0027145804],"category_scores_gemma":[0.0001478066,0.00025340173,0.00032759117,0.0002505792,0.0003541199,0.00030017848,0.00036441543,0.0005998762,0.0013492352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000086511056,0.000011244449,0.0010907036,0.00006990802,0.000004934912,0.00006185556,0.000033734297,0.00003462589,0.9945045,0.00044473316,0.00014674515,0.0035104658],"study_design_scores_gemma":[0.000012370185,0.000089948386,0.02989523,0.000017705166,0.000023119235,0.00029756874,0.00010326765,0.00055078126,0.94968486,0.00013631124,0.01917844,0.000010424244],"about_ca_topic_score_codex":0.0015059873,"about_ca_topic_score_gemma":0.0034243555,"teacher_disagreement_score":0.0027145804,"about_ca_system_score_codex":0.0006543448,"about_ca_system_score_gemma":0.0004052503,"threshold_uncertainty_score":0.009081185},"labels":[],"label_agreement":null},{"id":"W4386314838","doi":"10.37349/etat.2023.00166","title":"Medicinal chemistry advances in targeting class I histone deacetylases","year":2023,"lang":"en","type":"review","venue":"Exploration of Targeted Anti-tumor Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Histone; Epigenetics; Acetylation; HDAC11; Histone deacetylase; Biology; Cancer epigenetics; Computational biology; Cell biology; Chemistry; Cancer research; DNA; Gene; Genetics; Histone methyltransferase","score_opus":0.05830067147148174,"score_gpt":0.3838318647561858,"score_spread":0.32553119328470403,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386314838","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0007186939,0.9916294,0.0007321385,0.00044782824,0.00058204995,0.00001939163,0.000077385266,0.00003834171,0.005754683],"genre_scores_gemma":[0.003052415,0.9931068,0.0005610916,0.00038929816,0.00026757296,0.000016951222,0.000095795294,0.0000041198623,0.0025060195],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998604,0.000019354027,0.000011767101,0.00003272716,0.000054617125,0.000021149717],"domain_scores_gemma":[0.99988365,0.000044385808,0.000018599798,0.0000056524914,0.000032284865,0.000015450732],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042726658,0.0008313828,0.00086304394,0.0014317742,0.00024246414,0.0007261138,0.00070488814,0.00071719097,0.0058340365],"category_scores_gemma":[0.00044860053,0.0003004857,0.00052463013,0.001319509,0.00034061194,0.0010061495,0.0005888321,0.0018224552,0.0027662474],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013086108,0.0001957551,0.00014976163,0.015906317,0.000116068026,0.0002374241,0.00007494058,0.0013026423,0.009231594,0.013755791,0.04641819,0.91248065],"study_design_scores_gemma":[0.00003310305,0.00019737452,0.000351729,0.00080941996,0.000071959075,0.00053821533,0.000019252755,0.0002282251,0.0016555514,0.0020258082,0.99405587,0.000013587537],"about_ca_topic_score_codex":0.00058383105,"about_ca_topic_score_gemma":0.0010634445,"teacher_disagreement_score":0.0058340365,"about_ca_system_score_codex":0.00056871003,"about_ca_system_score_gemma":0.0006212424,"threshold_uncertainty_score":0.019516826},"labels":[],"label_agreement":null},{"id":"W4386333120","doi":"10.1101/2023.08.29.555280","title":"Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Horizon 2020 Framework Programme; ZonMw; China Scholarship Council; Fundação de Amparo à Pesquisa do Estado de São Paulo; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Velux Stiftung","keywords":"HDAC1; Histone deacetylase; HDAC3; Histone deacetylase 2; Histone deacetylase inhibitor; In vivo; Biology; Longevity; Transcriptome; Senescence; Gene expression; Fibrosis; Epigenetics; Bioinformatics; Cancer research; Histone; Medicine; Gene; Cell biology; Pathology; Genetics","score_opus":0.013534655103607747,"score_gpt":0.24297360516046804,"score_spread":0.2294389500568603,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386333120","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900377,0.0028881088,0.0031348374,0.00017234069,0.00016520504,0.000060800576,0.0016865944,0.00034419046,0.0015102612],"genre_scores_gemma":[0.9860518,0.0022409365,0.0043631457,0.00026533057,0.0000360011,0.00012451981,0.001837263,0.00007076963,0.0050102323],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979013,0.000018417586,0.000028965698,0.00006152059,0.00004342825,0.000057650017],"domain_scores_gemma":[0.99984646,0.000011536813,0.00004873275,0.000016039503,0.000011983112,0.0000651176],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020992091,0.0006660209,0.0006046829,0.00069529674,0.00018492981,0.00027304323,0.00033480418,0.0004817002,0.0018158416],"category_scores_gemma":[0.00007392586,0.00027302525,0.00071434723,0.00023284573,0.00029615723,0.0002972123,0.0001826163,0.0009896033,0.00037674594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030442514,0.00008891601,0.00013164528,0.00003088267,0.000011154338,0.000027064398,0.0000064107867,0.000043731972,0.998156,0.000040152376,0.000060821072,0.0010987964],"study_design_scores_gemma":[0.000061973005,0.0021149588,0.0033092326,0.000009483089,0.00004026673,0.00011463989,0.000023074443,0.0005931953,0.9923539,0.000035643498,0.0013369278,0.000006766725],"about_ca_topic_score_codex":0.0006444701,"about_ca_topic_score_gemma":0.0011934066,"teacher_disagreement_score":0.0018158416,"about_ca_system_score_codex":0.0002623116,"about_ca_system_score_gemma":0.00021964447,"threshold_uncertainty_score":0.006074667},"labels":[],"label_agreement":null},{"id":"W4386373783","doi":"10.1158/0008-5472.24071637.v1","title":"Supplementary Data from CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Myeloid leukemia; CD36; Cancer research; Oncology; Medicine; Internal medicine; Metastasis; Cancer; Receptor","score_opus":0.047305249814710904,"score_gpt":0.3360460162920147,"score_spread":0.2887407664773038,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386373783","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.004767946,0.00037776068,0.0029956733,0.0013743585,0.001841394,0.000103045044,0.9752483,0.0023111347,0.010980519],"genre_scores_gemma":[0.025494568,0.0008713972,0.012941447,0.0006831276,0.0005690076,0.0005017917,0.9338455,0.0016713594,0.023421885],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.998511,0.000080348684,0.00012869987,0.00020653784,0.0007434941,0.0003299446],"domain_scores_gemma":[0.9967289,0.0012922472,0.00018000964,0.0005852019,0.0005427481,0.00067083875],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009393705,0.0018723488,0.0015140407,0.0031233174,0.0013719166,0.0017767425,0.0016928827,0.001521941,0.6174878],"category_scores_gemma":[0.004252123,0.0010949398,0.0012988243,0.0027779632,0.00039309767,0.0012483627,0.001057075,0.0020761064,0.1714372],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009965629,0.00023769718,0.001803431,0.0013645585,0.00013247163,0.00034996582,0.00008629659,0.0010426132,0.025030045,0.0040602456,0.9418665,0.023029571],"study_design_scores_gemma":[0.0019707866,0.0004038032,0.038216513,0.00056233734,0.0001931195,0.0015542018,0.00025899286,0.007541606,0.051546726,0.014857838,0.8826846,0.0002095431],"about_ca_topic_score_codex":0.0061531696,"about_ca_topic_score_gemma":0.009993275,"teacher_disagreement_score":0.6174878,"about_ca_system_score_codex":0.0013132141,"about_ca_system_score_gemma":0.0020886431,"threshold_uncertainty_score":0.5456072},"labels":[],"label_agreement":null},{"id":"W4386379170","doi":"10.1158/0008-5472.24071637","title":"Supplementary Data from CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Myeloid leukemia; CD36; Cancer research; Oncology; Metastasis; Medicine; Internal medicine; Cancer; Receptor","score_opus":0.047305249814710904,"score_gpt":0.3360460162920147,"score_spread":0.2887407664773038,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386379170","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.004767946,0.00037776068,0.0029956733,0.0013743585,0.001841394,0.000103045044,0.9752483,0.0023111347,0.010980519],"genre_scores_gemma":[0.025494568,0.0008713972,0.012941447,0.0006831276,0.0005690076,0.0005017917,0.9338455,0.0016713594,0.023421885],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.998511,0.000080348684,0.00012869987,0.00020653784,0.0007434941,0.0003299446],"domain_scores_gemma":[0.9967289,0.0012922472,0.00018000964,0.0005852019,0.0005427481,0.00067083875],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009393705,0.0018723488,0.0015140407,0.0031233174,0.0013719166,0.0017767425,0.0016928827,0.001521941,0.6174878],"category_scores_gemma":[0.004252123,0.0010949398,0.0012988243,0.0027779632,0.00039309767,0.0012483627,0.001057075,0.0020761064,0.1714372],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009965629,0.00023769718,0.001803431,0.0013645585,0.00013247163,0.00034996582,0.00008629659,0.0010426132,0.025030045,0.0040602456,0.9418665,0.023029571],"study_design_scores_gemma":[0.0019707866,0.0004038032,0.038216513,0.00056233734,0.0001931195,0.0015542018,0.00025899286,0.007541606,0.051546726,0.014857838,0.8826846,0.0002095431],"about_ca_topic_score_codex":0.0061531696,"about_ca_topic_score_gemma":0.009993275,"teacher_disagreement_score":0.6174878,"about_ca_system_score_codex":0.0013132141,"about_ca_system_score_gemma":0.0020886431,"threshold_uncertainty_score":0.5456072},"labels":[],"label_agreement":null},{"id":"W4386761408","doi":"10.3791/65080","title":"Quantification of Global Histone Post Translational Modifications Using Intranuclear Flow Cytometry in Isolated Mouse Brain Microglia","year":2023,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Histone; Biology; Chromatin; Epigenetics; Epigenomics; Acetylation; Chromatin immunoprecipitation; Cell biology; Gene expression; Bromodomain; Regulation of gene expression; Computational biology; Genetics; DNA methylation; Gene; Promoter","score_opus":0.04091618551791698,"score_gpt":0.44979698934113893,"score_spread":0.40888080382322195,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386761408","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8378534,0.0037455377,0.14630516,0.00025521382,0.00017750297,0.00061747705,0.004385279,0.001611777,0.0050487546],"genre_scores_gemma":[0.77497864,0.0056827962,0.2023098,0.0005688723,0.00015666256,0.0033087672,0.0045387275,0.00030728817,0.008148478],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99947447,0.000043013304,0.000045407145,0.00020291256,0.0001376251,0.00009664205],"domain_scores_gemma":[0.99963355,0.00007290856,0.000091940485,0.00003987659,0.00009789459,0.00006368494],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006700829,0.0006682713,0.00045558985,0.0014452554,0.00050778926,0.00048052688,0.00049037754,0.00065087515,0.0011927424],"category_scores_gemma":[0.00027006894,0.00020216704,0.00036549746,0.0007228161,0.00043240617,0.00033565256,0.00036092484,0.0012531875,0.00049513177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000050428276,0.000025805095,0.00028518497,0.000039250666,0.0000068679346,0.000016014577,0.000033261258,0.000095823445,0.9975883,0.00012028379,0.000036490026,0.0017022977],"study_design_scores_gemma":[0.00002010112,0.0002173948,0.00739619,0.000020519525,0.000038420138,0.00008057205,0.000056379395,0.0027011419,0.98780173,0.00028172391,0.0013720578,0.000013850838],"about_ca_topic_score_codex":0.0010989613,"about_ca_topic_score_gemma":0.0023208263,"teacher_disagreement_score":0.0014452554,"about_ca_system_score_codex":0.00056016026,"about_ca_system_score_gemma":0.00038630675,"threshold_uncertainty_score":0.0040643215},"labels":[],"label_agreement":null},{"id":"W4386935335","doi":"10.1038/s41467-023-41067-2","title":"The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Israel Science Foundation; Weizmann Institute of Science","keywords":"HDAC3; Erg; Transcription factor; Cancer research; Biology; Cell biology; ETS transcription factor family; Repressor; Myeloid leukemia; Haematopoiesis; Genetics; Gene; Histone; Stem cell; Histone deacetylase; Biochemistry; Retinal","score_opus":0.028098252525617033,"score_gpt":0.33356355661174714,"score_spread":0.3054653040861301,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386935335","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99570036,0.00108765,0.001121984,0.000099233956,0.000023901954,0.000008655491,0.00019226973,0.000046027908,0.0017200236],"genre_scores_gemma":[0.9980767,0.00027056967,0.00031923037,0.00002648395,0.0000030762803,0.0000050070767,0.00017363009,0.000009532867,0.0011158176],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990284,0.000013495712,0.000004772302,0.000017740387,0.00002112735,0.000040037645],"domain_scores_gemma":[0.9999536,0.000005904963,0.000012501856,0.0000054556176,0.000004275512,0.00001824823],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007280176,0.00017986979,0.00016630735,0.000095287345,0.00013773341,0.00023983612,0.00019978531,0.00013917468,0.0013815226],"category_scores_gemma":[0.00007178328,0.00007715935,0.00015873533,0.00008114627,0.0002186626,0.00011528901,0.00015411923,0.0003042145,0.00035717216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011162562,0.000011032087,0.00016595394,0.000009571517,0.000002922139,0.000019550116,0.0000038371472,0.000021182568,0.99914396,0.00006474514,0.000026700442,0.0004188806],"study_design_scores_gemma":[0.000015242532,0.00012213072,0.008956767,0.0000025808365,0.000009995467,0.00012663931,0.000024036673,0.00070750504,0.98873466,0.000033977474,0.0012637252,0.0000027458034],"about_ca_topic_score_codex":0.0009263261,"about_ca_topic_score_gemma":0.0020871488,"teacher_disagreement_score":0.0013815226,"about_ca_system_score_codex":0.000343718,"about_ca_system_score_gemma":0.00017745538,"threshold_uncertainty_score":0.004621625},"labels":[],"label_agreement":null},{"id":"W4387849370","doi":"10.1016/j.lfs.2023.122195","title":"Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction","year":2023,"lang":"en","type":"article","venue":"Life Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor","funders":"North South University; Ministry of Education, Government of the People's Republic of Bangladesh","keywords":"Protein kinase B; PI3K/AKT/mTOR pathway; Biology; Neuroprotection; Signal transduction; Dendritic spine; Cell biology; Neuroscience; Hippocampal formation","score_opus":0.026640053075991207,"score_gpt":0.28261026738200157,"score_spread":0.25597021430601036,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4387849370","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9958437,0.00078215805,0.0017283099,0.00029152242,0.00009790439,0.000029926776,0.00031607543,0.00011507817,0.0007952382],"genre_scores_gemma":[0.99619174,0.00066674384,0.0010064599,0.000085817635,0.000013043931,0.000042195,0.00024566738,0.000016882965,0.0017313814],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983203,0.000015177324,0.000019259556,0.000045706758,0.000020089034,0.00006762627],"domain_scores_gemma":[0.9998996,0.0000061574497,0.000028543369,0.0000128080155,0.0000072457483,0.000045656783],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014870003,0.00051669125,0.0004558331,0.00026655183,0.00028855525,0.00033322792,0.00035625751,0.0004946718,0.002233238],"category_scores_gemma":[0.0001529266,0.00027268135,0.00047157315,0.00015457856,0.00052607374,0.0004997477,0.00032707627,0.0013858633,0.00034273506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.004185148,0.0002156788,0.00034738457,0.000063169704,0.000023164404,0.00027570958,0.000035411183,0.00011463533,0.9904839,0.0003991067,0.00013461574,0.0037220973],"study_design_scores_gemma":[0.0003910466,0.0017681251,0.005995068,0.000016004153,0.00012151902,0.000453033,0.00013556595,0.0011939341,0.98755383,0.0003033325,0.0020537083,0.0000148559375],"about_ca_topic_score_codex":0.0012287924,"about_ca_topic_score_gemma":0.0015983224,"teacher_disagreement_score":0.002233238,"about_ca_system_score_codex":0.00044270777,"about_ca_system_score_gemma":0.0005524131,"threshold_uncertainty_score":0.007470906},"labels":[],"label_agreement":null},{"id":"W4388537984","doi":"10.1016/j.physbeh.2023.114406","title":"Differential expression of Hdac2 in male and female mice of differing social status","year":2023,"lang":"en","type":"article","venue":"Physiology & Behavior","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Nova Scotia Research Innovation Trust","keywords":"Histone deacetylase 2; Epigenetics; Biology; Hippocampus; Hippocampal formation; Gene expression; Dominance (genetics); Histone deacetylase; Histone; Neuroscience; HDAC1; Genetics; Gene","score_opus":0.019579715029431108,"score_gpt":0.3120620832846158,"score_spread":0.2924823682551847,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4388537984","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99265337,0.0008309073,0.0018850312,0.00027567547,0.0001471627,0.000020276626,0.0022443398,0.0001429032,0.0018003491],"genre_scores_gemma":[0.9713705,0.0007716885,0.0023493615,0.0002734041,0.00007375109,0.00012775461,0.0018369502,0.00027621142,0.02292043],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9995484,0.000029923054,0.00002423007,0.00014229874,0.00008774366,0.00016752217],"domain_scores_gemma":[0.99944824,0.000041801537,0.0001551731,0.000035418354,0.0000391677,0.0002802281],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019421981,0.0007280435,0.00055483676,0.0017324185,0.00044309555,0.0007016276,0.00040285563,0.00069839373,0.005239724],"category_scores_gemma":[0.00019225352,0.00045911223,0.00066714245,0.00038080552,0.0008435646,0.00046313682,0.00043513754,0.0017033637,0.00088178],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00087511167,0.000048671893,0.0005425733,0.000013911444,0.000008729468,0.000052832234,0.000031543354,0.000017502674,0.9975327,0.00012328106,0.000049648854,0.0007035389],"study_design_scores_gemma":[0.000109977096,0.00087885367,0.045026958,0.00001611134,0.000090997535,0.00045614596,0.00035316765,0.000620572,0.9503595,0.00020570502,0.0018476967,0.000034312037],"about_ca_topic_score_codex":0.0014148356,"about_ca_topic_score_gemma":0.0025786979,"teacher_disagreement_score":0.005239724,"about_ca_system_score_codex":0.00061498693,"about_ca_system_score_gemma":0.00029407095,"threshold_uncertainty_score":0.017528653},"labels":[],"label_agreement":null},{"id":"W4389219695","doi":"10.1182/blood-2023-189515","title":"LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hamilton Health Sciences; Juravinski Cancer Centre; Population Health Research Institute; McMaster University","funders":"","keywords":"Venetoclax; Myeloid leukemia; Azacitidine; Myeloid; Cancer research; Leukemia; Pharmacology; Biology; Medicine; Internal medicine; Chronic lymphocytic leukemia; Biochemistry; DNA methylation","score_opus":0.005019309610893325,"score_gpt":0.22567310532348753,"score_spread":0.2206537957125942,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389219695","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99131143,0.004438658,0.0005823743,0.00015045708,0.00006850483,0.000076973796,0.0007252118,0.00018778065,0.002458652],"genre_scores_gemma":[0.99449486,0.0018643531,0.0010773503,0.000056431087,0.000021202624,0.00005077159,0.00093166815,0.000011402486,0.0014920436],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999424,0.000011952359,0.0000067373553,0.000011096236,0.000013478278,0.0000142758545],"domain_scores_gemma":[0.9999528,0.000011102078,0.000009446739,0.0000062772524,0.0000037130533,0.000016737235],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012449858,0.000282026,0.000329829,0.00023390555,0.00014426894,0.00019542241,0.00016991372,0.00016600634,0.0023845558],"category_scores_gemma":[0.00009177326,0.000072553165,0.0002495169,0.0001851318,0.00016226474,0.00013288193,0.00015847581,0.00050520274,0.0003548211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0023199655,0.0005180904,0.0009012429,0.0002956444,0.000039767998,0.000086633125,0.00003580446,0.0004205019,0.97623175,0.00010958902,0.00070842926,0.018332606],"study_design_scores_gemma":[0.00034412747,0.0065300255,0.014636958,0.00002114074,0.00008633738,0.0005529359,0.000038950315,0.0010454648,0.9670584,0.00006269449,0.009610065,0.000012905341],"about_ca_topic_score_codex":0.00039030553,"about_ca_topic_score_gemma":0.0010546307,"teacher_disagreement_score":0.0023845558,"about_ca_system_score_codex":0.00019912064,"about_ca_system_score_gemma":0.00023661292,"threshold_uncertainty_score":0.007977068},"labels":[],"label_agreement":null},{"id":"W4389233361","doi":"10.1182/blood-2023-189163","title":"Chronic TNF in the Aging Microenvironment Exacerbates <i>TET2-</i>loss-of-Function Myeloid Expansion","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Queen's University; Ontario Institute for Cancer Research; McMaster University","funders":"","keywords":"Medicine; Myeloid; Function (biology); Tumor necrosis factor alpha; Cancer research; Internal medicine; Immunology; Biology; Cell biology","score_opus":0.010387092898658523,"score_gpt":0.24915912809689733,"score_spread":0.2387720351982388,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389233361","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99510765,0.0013166372,0.0009687936,0.00014345668,0.00007311198,0.00004794545,0.000939368,0.00011944546,0.0012836626],"genre_scores_gemma":[0.9953733,0.0005887823,0.00066830334,0.00013022598,0.000035784356,0.000046982776,0.0007335031,0.00002149892,0.0024015685],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978524,0.000028128246,0.000025185978,0.000053061027,0.00003777785,0.00007065415],"domain_scores_gemma":[0.99974734,0.000016428265,0.00009978411,0.00001989656,0.000014503301,0.00010201335],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016370288,0.00044226108,0.00036329366,0.00022997109,0.00015252644,0.00038698275,0.00014172966,0.0003646132,0.002790571],"category_scores_gemma":[0.00009668637,0.0001505921,0.0002170087,0.00014063397,0.0002699006,0.0002287179,0.00026720448,0.0008155661,0.0007277046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005317455,0.00008384904,0.0017666207,0.000061729486,0.0000074780237,0.00020834757,0.000020580566,0.000027389158,0.9961862,0.000042457217,0.00016643945,0.0008971323],"study_design_scores_gemma":[0.00012275389,0.0049604885,0.09029436,0.00007634831,0.00011609541,0.004877856,0.00028758374,0.000872988,0.8898639,0.0002024572,0.008304146,0.000021098254],"about_ca_topic_score_codex":0.00025024355,"about_ca_topic_score_gemma":0.00051712134,"teacher_disagreement_score":0.002790571,"about_ca_system_score_codex":0.00018689621,"about_ca_system_score_gemma":0.00016289586,"threshold_uncertainty_score":0.009335399},"labels":[],"label_agreement":null},{"id":"W4389280230","doi":"10.1016/j.annonc.2023.10.462","title":"354O A phase Ib/II study of nanatinostat (Nstat) plus valganciclovir (VGCV) in EBV+ solid tumors and with pembrolizumab (PEM) in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC)","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Valganciclovir; Nasopharyngeal carcinoma; Oncology; Phases of clinical research; Internal medicine; Cancer research; Virology; Chemotherapy; Radiation therapy; Virus; Ganciclovir; Cancer; Immunotherapy","score_opus":0.06200147893821727,"score_gpt":0.4070001838657971,"score_spread":0.34499870492757984,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389280230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99142563,0.002735481,0.00039218517,0.00032517663,0.00017535107,0.0013825966,0.0010385404,0.00009009684,0.0024349368],"genre_scores_gemma":[0.98827237,0.002601534,0.0015486712,0.00055423536,0.00010900851,0.0010236716,0.0021693814,0.00002646276,0.0036947564],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99979085,0.000071172035,0.000011385623,0.000039823994,0.000019822992,0.00006700074],"domain_scores_gemma":[0.99978584,0.000023863544,0.000020128897,0.000016236721,0.000012111426,0.00014175805],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00069835444,0.00089372025,0.0012675691,0.00039311062,0.00035562724,0.0009546607,0.0006740129,0.00090907287,0.0039479244],"category_scores_gemma":[0.0003216898,0.00042331396,0.0012633752,0.00035389006,0.00069483335,0.0005221803,0.00020607519,0.0019050228,0.00091232767],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.6733594,0.07720259,0.0063587097,0.0009530263,0.0022915327,0.00032834426,0.0003274699,0.0030013241,0.090872236,0.0006312325,0.004180401,0.14049374],"study_design_scores_gemma":[0.50372326,0.46235862,0.013259061,0.000057885474,0.0012794553,0.00031538532,0.00012379298,0.0014285072,0.00971186,0.0003488874,0.007346838,0.00004640816],"about_ca_topic_score_codex":0.0033529848,"about_ca_topic_score_gemma":0.008102367,"teacher_disagreement_score":0.0039479244,"about_ca_system_score_codex":0.0009851364,"about_ca_system_score_gemma":0.0014789461,"threshold_uncertainty_score":0.013207078},"labels":[],"label_agreement":null},{"id":"W4389429444","doi":"10.1021/acs.jmedchem.3c01236","title":"Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Ontario Ministry of Research, Innovation and Science; Government of Ontario; Canada Research Chairs; Canada Foundation for Innovation; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Chemistry; Duchenne muscular dystrophy; Histone; Epigenetics; Histone deacetylase; Myogenesis; Drug discovery; Cancer research; Biochemistry; Cell biology; Pharmacology; In vitro; Biology; Genetics; Gene","score_opus":0.006763002857175085,"score_gpt":0.24722693821675792,"score_spread":0.24046393535958283,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389429444","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9602385,0.012117644,0.014576147,0.00068142934,0.000102557126,0.0003022949,0.0007175131,0.00048468128,0.010779198],"genre_scores_gemma":[0.9854533,0.0042910525,0.0048507717,0.00014067824,0.000014910389,0.000043727712,0.00033144405,0.00001546131,0.0048587094],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993265,0.0000106178495,0.000004061999,0.000015094462,0.000017586279,0.000019993766],"domain_scores_gemma":[0.99997616,0.0000015271925,0.0000085226775,0.0000024528179,0.000003958887,0.000007457938],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017392696,0.0003851055,0.0002207084,0.0001761489,0.00012750774,0.00017032507,0.0002936591,0.0003202079,0.0009350388],"category_scores_gemma":[0.00006699826,0.00013256629,0.00018398059,0.00015312753,0.00017764296,0.00014552764,0.00019334273,0.00029678442,0.0002913309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023151416,0.00008856316,0.00032004027,0.00012551557,0.000020555379,0.00019968924,0.000028903924,0.0007065943,0.97157943,0.0008744847,0.0006147712,0.02520997],"study_design_scores_gemma":[0.00009555834,0.001555627,0.0014801297,0.0000110739875,0.000032796437,0.00061141973,0.000013726055,0.001173444,0.98128694,0.00009662004,0.013632364,0.000010257336],"about_ca_topic_score_codex":0.0010103427,"about_ca_topic_score_gemma":0.0022928296,"teacher_disagreement_score":0.0010103427,"about_ca_system_score_codex":0.00048388226,"about_ca_system_score_gemma":0.0003070049,"threshold_uncertainty_score":0.0035108328},"labels":[],"label_agreement":null},{"id":"W4389609538","doi":"10.1016/j.isci.2023.108681","title":"HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"HORIZON EUROPE Framework Programme; China Scholarship Council; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; H2020 European Research Council; Velux Stiftung","keywords":"HDAC1; Transcriptome; Phenotype; Bioinformatics; Dementia; Histone deacetylase; Histone deacetylase inhibitor; Disease; Medicine; Contractility; Epigenetics; Longevity; Fibrosis; HDAC3; Translation (biology); Biology; Histone; Neuroscience; Gene expression; Gene; Internal medicine; Genetics; Gerontology; Messenger RNA","score_opus":0.019083901995955815,"score_gpt":0.2873316080898687,"score_spread":0.26824770609391285,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389609538","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98315674,0.0050257244,0.005953858,0.0002790195,0.00017882913,0.00006641493,0.0021718098,0.0004978992,0.0026696373],"genre_scores_gemma":[0.97965014,0.0043336656,0.0054187826,0.00039643637,0.00004788002,0.00009383523,0.0020999582,0.00009873711,0.007860587],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998778,0.0000114472605,0.000013013461,0.000039078623,0.0000259846,0.000032694912],"domain_scores_gemma":[0.99989367,0.000005742537,0.000035017845,0.000010204448,0.000012036594,0.000043307096],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458439,0.000669764,0.00051082973,0.00053334195,0.00015480041,0.00028318213,0.00024176906,0.00030291185,0.0016923565],"category_scores_gemma":[0.00008136982,0.00016627485,0.0004363026,0.0001491145,0.00022188958,0.00028804678,0.00015978374,0.00082778255,0.00034311615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00045462232,0.00015356907,0.00024786813,0.000048988313,0.000018326416,0.000030157145,0.000009096214,0.00010539329,0.9938199,0.00008066131,0.0001345654,0.004896886],"study_design_scores_gemma":[0.000091151,0.0033285245,0.0066031683,0.000016635107,0.00008146611,0.00013949648,0.000027521426,0.0006980374,0.9853849,0.00011181802,0.0035083164,0.000008849031],"about_ca_topic_score_codex":0.00048720653,"about_ca_topic_score_gemma":0.0015960019,"teacher_disagreement_score":0.0016923565,"about_ca_system_score_codex":0.00024279377,"about_ca_system_score_gemma":0.00023863453,"threshold_uncertainty_score":0.0056614876},"labels":[],"label_agreement":null},{"id":"W4391115545","doi":"10.1016/j.bbamcr.2024.119677","title":"12th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration","year":2024,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Neurodegeneration; Programmed cell death; Apoptosis; Cancer; Neuroscience; Biology; Medicine; Cancer research; Bioinformatics; Disease; Genetics; Internal medicine","score_opus":0.08752313648863094,"score_gpt":0.4308856510377362,"score_spread":0.34336251454910527,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4391115545","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00009920903,0.98100084,0.00018899492,0.0054541687,0.010962363,0.000009511127,0.000054211247,0.00003263237,0.0021980572],"genre_scores_gemma":[0.0012245204,0.9687329,0.0004775241,0.01063825,0.008056102,0.000029470582,0.00013526624,0.00002401434,0.010682042],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9994536,0.00009893678,0.00005971271,0.000087102984,0.0001935825,0.00010705138],"domain_scores_gemma":[0.9988695,0.00044149076,0.000103745,0.00005291726,0.00030855814,0.00022380108],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002025876,0.0014725955,0.001692815,0.003182258,0.0005593392,0.0021312118,0.0014408592,0.004044257,0.008859568],"category_scores_gemma":[0.0024854785,0.0004065355,0.00077526725,0.0023794489,0.0016041801,0.0023931,0.0023152505,0.0057652546,0.005643827],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021402801,0.00008590158,0.00009692822,0.004324421,0.000074202435,0.00018739373,0.000060372487,0.00022354902,0.0008072497,0.005736882,0.54454327,0.44364586],"study_design_scores_gemma":[0.00002361039,0.000062299616,0.0002818109,0.0016485194,0.000043864693,0.00025681697,0.000015545298,0.000028938512,0.00017537932,0.00073140743,0.9967231,0.000008594529],"about_ca_topic_score_codex":0.003384732,"about_ca_topic_score_gemma":0.009551181,"teacher_disagreement_score":0.008859568,"about_ca_system_score_codex":0.0030097007,"about_ca_system_score_gemma":0.0029700566,"threshold_uncertainty_score":0.02963823},"labels":[],"label_agreement":null},{"id":"W4391437267","doi":"10.1016/j.celrep.2024.113707","title":"H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Fundacja na rzecz Nauki Polskiej; Narodowe Centrum Nauki; University of Oxford","keywords":"Mutant; Histone; Histone H3; Glioma; Biology; Genetics; Chemistry; Cancer research; Molecular biology; Cell biology; Gene","score_opus":0.011487063262318395,"score_gpt":0.25930597777133285,"score_spread":0.24781891450901444,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4391437267","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98945063,0.0023351922,0.0030590682,0.00016591571,0.000050570125,0.000030232472,0.001619672,0.0001662645,0.0031224375],"genre_scores_gemma":[0.99137306,0.0009988454,0.0017483325,0.00006293538,0.0000060124953,0.000028139732,0.0018936172,0.000033047698,0.0038560445],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991167,0.0000081915705,0.00000920204,0.000022195547,0.000027144883,0.000021538282],"domain_scores_gemma":[0.9999629,0.0000062348126,0.000008873261,0.00000709193,0.0000048045467,0.000010214872],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008871767,0.00021547882,0.00023021415,0.00010111412,0.00011106185,0.0002273061,0.00027290217,0.00014883862,0.0012971986],"category_scores_gemma":[0.000055791792,0.000105420724,0.00019789417,0.00014744315,0.00013211754,0.00009665679,0.00017623071,0.00037495073,0.0005703002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009354188,0.000024701272,0.00016692698,0.000033059725,0.0000059494764,0.00003421419,0.00001237814,0.00004346767,0.99830604,0.000060760172,0.000111102265,0.0011078788],"study_design_scores_gemma":[0.0000117962045,0.000099530334,0.0035007112,0.0000022501943,0.00000826254,0.000083116705,0.000016066215,0.00045863318,0.99315506,0.000014924717,0.002647715,0.0000017974401],"about_ca_topic_score_codex":0.0023811858,"about_ca_topic_score_gemma":0.0030005646,"teacher_disagreement_score":0.0023811858,"about_ca_system_score_codex":0.00024425122,"about_ca_system_score_gemma":0.00018665081,"threshold_uncertainty_score":0.004734695},"labels":[],"label_agreement":null},{"id":"W4391541155","doi":"10.1007/s00018-023-05104-z","title":"A glimpse into novel acylations and their emerging role in regulating cancer metastasis","year":2024,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Genetics; Medical and Health Science and Technology Development Project of Shandong Province; Natural Science Foundation of Shandong Province; Northeast Normal University","keywords":"Metastasis; Cancer; Epigenetics; Biology; Proteomics; Histone; Mechanism (biology); Computational biology; Signal transduction; Cancer research; Bioinformatics; Biochemistry; Genetics; Gene","score_opus":0.014991940690568075,"score_gpt":0.30038225145645253,"score_spread":0.28539031076588445,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4391541155","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.015891766,0.9649827,0.008459478,0.003923505,0.00066698383,0.00003829455,0.00031196393,0.00011844069,0.005606848],"genre_scores_gemma":[0.046504132,0.9406488,0.0050994805,0.0015576094,0.0008877818,0.000033211254,0.0004571548,0.000026780783,0.0047851834],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990296,0.000014455719,0.000015455891,0.000022298465,0.000024784997,0.00001997705],"domain_scores_gemma":[0.99987876,0.000028217046,0.000026417847,0.000007867474,0.000039074526,0.00001957795],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037055576,0.00055970077,0.00058190693,0.0010245772,0.00021126082,0.00086161133,0.000281001,0.00066260964,0.0018213426],"category_scores_gemma":[0.00031325305,0.00024298206,0.00059501105,0.0007212077,0.00046146242,0.0016222117,0.00042603503,0.0013142827,0.0009354348],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00078290614,0.00012819954,0.0050091227,0.011752752,0.00022275306,0.0036036922,0.0005965469,0.0017852521,0.38279414,0.029480742,0.016625479,0.5472185],"study_design_scores_gemma":[0.000047686262,0.000789503,0.011314567,0.0010105633,0.0002901605,0.006565052,0.0004740152,0.001329356,0.07572112,0.015610574,0.8867493,0.000098092234],"about_ca_topic_score_codex":0.0006416414,"about_ca_topic_score_gemma":0.0013508075,"teacher_disagreement_score":0.0018213426,"about_ca_system_score_codex":0.0004586424,"about_ca_system_score_gemma":0.0005568672,"threshold_uncertainty_score":0.0060929656},"labels":[],"label_agreement":null},{"id":"W4392597434","doi":"10.1080/17460441.2024.2322990","title":"Molecular hybridization: a powerful tool for multitarget drug discovery","year":2024,"lang":"en","type":"article","venue":"Expert Opinion on Drug Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos; Ministry of Health, British Columbia; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Drug discovery; Pharmacophore; Computational biology; Disease; Biology; Drug; Bioinformatics; Neuroscience; Medicine; Pharmacology; Pathology","score_opus":0.010093436562879953,"score_gpt":0.3078279918440096,"score_spread":0.29773455528112963,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4392597434","genre_codex":"methods","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0071771215,0.19925797,0.7157345,0.014743912,0.00453886,0.0006209717,0.0012840563,0.006531554,0.050111167],"genre_scores_gemma":[0.14272648,0.28214428,0.517237,0.014312272,0.004008171,0.002306477,0.0021150028,0.0011780455,0.033972234],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99782205,0.00066379027,0.000072296556,0.00032508347,0.0010044249,0.00011236286],"domain_scores_gemma":[0.9988902,0.0005957402,0.00015274136,0.0001599048,0.0001284544,0.0000729073],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0029676626,0.0014539008,0.0019638715,0.001707969,0.0006866833,0.0028204033,0.0022189082,0.0028320113,0.012895313],"category_scores_gemma":[0.0027663196,0.0012197376,0.0014540545,0.0012558552,0.0024507293,0.0038774165,0.0028324611,0.0062530767,0.007120653],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003942917,0.00019937515,0.0005036392,0.005854828,0.00047255887,0.0008961291,0.00033064827,0.006712616,0.25217363,0.18253155,0.07470917,0.47522154],"study_design_scores_gemma":[0.00017378548,0.00071704737,0.00033067277,0.0006451458,0.0001827577,0.0017441299,0.00010475114,0.012879599,0.13062878,0.07241732,0.7800044,0.0001715642],"about_ca_topic_score_codex":0.0003834049,"about_ca_topic_score_gemma":0.00043538254,"teacher_disagreement_score":0.012895313,"about_ca_system_score_codex":0.001168404,"about_ca_system_score_gemma":0.00069441,"threshold_uncertainty_score":0.0431391},"labels":[],"label_agreement":null},{"id":"W4392683202","doi":"10.1186/s12885-024-12057-4","title":"High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line","year":2024,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Natural Science Foundation of China; York University; New York University Shanghai; East China Normal University; National Science Foundation","keywords":"Drug; Proteasome inhibitor; PI3K/AKT/mTOR pathway; Drug resistance; Cancer; Drug discovery; Pharmacology; Cancer cell; Proteasome; Medicine; Cancer research; Biology; Bioinformatics; Biochemistry; Signal transduction; Internal medicine; Genetics","score_opus":0.02470710708846474,"score_gpt":0.318351059468777,"score_spread":0.29364395238031227,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4392683202","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9848246,0.0009602744,0.009164322,0.00014589558,0.00003374143,0.00008570071,0.001827784,0.00028193166,0.0026757554],"genre_scores_gemma":[0.9747731,0.00073794514,0.019269988,0.00016025954,0.000013076628,0.00015828587,0.0020589863,0.00007703591,0.0027511492],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997421,0.00002042201,0.000018888892,0.00006765224,0.000117556985,0.000033466276],"domain_scores_gemma":[0.9998466,0.000047335816,0.000032038854,0.000015943138,0.000039620925,0.000018543285],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016269901,0.00045123277,0.00041944534,0.00060086645,0.00020828327,0.00024649478,0.00027525838,0.00042769298,0.0010251108],"category_scores_gemma":[0.00012729138,0.00016531149,0.00041826427,0.00053759216,0.0002754122,0.00022830328,0.00021957014,0.0004864719,0.0003587272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003334697,0.00002572741,0.0003971643,0.000029395303,0.0000070893902,0.000041074312,0.000011074343,0.00010128258,0.99806935,0.000015339116,0.00004770614,0.0012214177],"study_design_scores_gemma":[0.0000056978365,0.00014354274,0.007560926,0.0000019018988,0.000024029681,0.00011642519,0.00003751023,0.0016029164,0.98994887,0.000019276304,0.00053163647,0.0000073322744],"about_ca_topic_score_codex":0.0015888702,"about_ca_topic_score_gemma":0.0026666538,"teacher_disagreement_score":0.0015888702,"about_ca_system_score_codex":0.00028991033,"about_ca_system_score_gemma":0.0001973812,"threshold_uncertainty_score":0.0034293532},"labels":[],"label_agreement":null},{"id":"W4394235854","doi":"10.6084/m9.figshare.23802662","title":"Histone deacetylase 3 regulates microglial function through histone deacetylation","year":2023,"lang":"en","type":"dataset","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Acetylation; Histone deacetylase; Histone deacetylase 2; HDAC11; Histone; HDAC10; Chemistry; Histone deacetylase 5; HDAC4; Cell biology; Function (biology); Cancer research; Biology; Biochemistry; Gene","score_opus":0.03199120865941275,"score_gpt":0.3291009155915967,"score_spread":0.29710970693218397,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4394235854","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0010029231,0.0004929791,0.00009470326,0.00013850098,0.000018168363,0.000022573015,0.99557894,0.00044233364,0.0022088552],"genre_scores_gemma":[0.0030637442,0.0006401546,0.00080763106,0.00006457377,0.0000049804303,0.0001494967,0.9933333,0.0001697406,0.0017664392],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99951255,0.000082491904,0.000042144395,0.00017350834,0.00011574229,0.00007352672],"domain_scores_gemma":[0.9992817,0.00026118665,0.00010533178,0.00007414445,0.00014146445,0.00013615667],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00048000473,0.0017688998,0.0013959476,0.0019603895,0.0006959279,0.0016351125,0.0013002817,0.000694744,0.105770044],"category_scores_gemma":[0.0022554551,0.00036899536,0.0010013079,0.0047626006,0.00022752727,0.00084349466,0.0011596875,0.0010125147,0.0439513],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00064834394,0.00004230686,0.0026786258,0.008442449,0.00017429766,0.00007375949,0.00007997177,0.0013081329,0.0038784323,0.00098628,0.9625064,0.019180974],"study_design_scores_gemma":[0.00071881927,0.00009103424,0.014348582,0.0007763789,0.00018727654,0.00010335767,0.00008625618,0.0010252142,0.0042057955,0.0017358878,0.97666717,0.000054270608],"about_ca_topic_score_codex":0.011300597,"about_ca_topic_score_gemma":0.0401352,"teacher_disagreement_score":0.105770044,"about_ca_system_score_codex":0.0017086286,"about_ca_system_score_gemma":0.0018638222,"threshold_uncertainty_score":0.35383606},"labels":[],"label_agreement":null},{"id":"W4394490826","doi":"10.6084/m9.figshare.22010267","title":"Niclosamide is a potential candidate for the treatment of chemo-resistant osteosarcoma","year":2023,"lang":"en","type":"dataset","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Health Services; Centre for Addiction and Mental Health","funders":"","keywords":"Niclosamide; Osteosarcoma; Pharmacology; Chemistry; Cancer research; Biology; Zoology","score_opus":0.028362473169860788,"score_gpt":0.3133946160591511,"score_spread":0.2850321428892903,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4394490826","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0019684855,0.0026908908,0.000116128685,0.00029095326,0.00005122306,0.00008366773,0.9923632,0.00033309762,0.0021023015],"genre_scores_gemma":[0.0036763516,0.0020526876,0.00088293635,0.00014686429,0.0000130590615,0.00024342796,0.9913333,0.00006970949,0.0015817554],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99961275,0.000074757365,0.000054115666,0.00011581341,0.00008824865,0.000054362346],"domain_scores_gemma":[0.99926645,0.00025470962,0.000128804,0.00006969313,0.00017742434,0.000103037986],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045833059,0.0010943474,0.0015435676,0.0023003707,0.00047599652,0.0011123307,0.001500692,0.0009173117,0.041570086],"category_scores_gemma":[0.0025040205,0.00026133453,0.0013625978,0.004115345,0.00017163488,0.00063654844,0.0008599779,0.0009258964,0.015544188],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017333131,0.00015505543,0.007837586,0.027508346,0.00075745303,0.00015610472,0.00007165873,0.0020493227,0.0049654525,0.0013783757,0.89472604,0.058661204],"study_design_scores_gemma":[0.0015970947,0.0002144504,0.019197708,0.0020583232,0.00091228454,0.00018715436,0.00008505365,0.001117376,0.0032188366,0.0015978656,0.96975327,0.000060690338],"about_ca_topic_score_codex":0.008264502,"about_ca_topic_score_gemma":0.025486097,"teacher_disagreement_score":0.041570086,"about_ca_system_score_codex":0.0010425568,"about_ca_system_score_gemma":0.002046242,"threshold_uncertainty_score":0.1390658},"labels":[],"label_agreement":null},{"id":"W4395039374","doi":"10.1161/circ.128.suppl_22.a19038","title":"Abstract 19038: Epigenetic Regulation of Canonical TNFa Pathway by HDAC1 Determines Survival of Cardiac Myocytes","year":2013,"lang":"en","type":"article","venue":"Circulation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Epigenetics; Myocyte; Tumor necrosis factor alpha; HDAC1; Cardiac myocyte; Cell biology; Internal medicine; Genetics; Histone; Gene; Biology","score_opus":0.011568351028952989,"score_gpt":0.25171622591674553,"score_spread":0.24014787488779255,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4395039374","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95868653,0.013315647,0.0071653854,0.0009080153,0.0005336623,0.00008062531,0.0070971726,0.0005571886,0.011655707],"genre_scores_gemma":[0.9553848,0.004403546,0.0028528187,0.00027305237,0.00015705323,0.000083111234,0.005905684,0.00015105751,0.030788913],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988675,0.0000097567545,0.000009290182,0.00003800378,0.00003056784,0.000025605968],"domain_scores_gemma":[0.9999417,0.0000054155034,0.000018646719,0.0000072695934,0.000007376,0.0000196137],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008754816,0.0003922227,0.00029911744,0.00017529656,0.00020591257,0.0003033746,0.00028604406,0.0002577173,0.011179649],"category_scores_gemma":[0.00007052182,0.0001634061,0.0002751201,0.00018414645,0.00023925715,0.00022861411,0.0002467593,0.0006898604,0.0031463036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001435924,0.000013630931,0.00010514936,0.000057067507,0.0000035807507,0.000043194672,0.0000067570472,0.000011798219,0.9980021,0.00011790824,0.00015030066,0.0013449584],"study_design_scores_gemma":[0.000045277036,0.0002833709,0.0066358815,0.000014809434,0.000020485899,0.00048042068,0.00002851725,0.00023516192,0.98098457,0.00010168852,0.011164296,0.0000056030444],"about_ca_topic_score_codex":0.00055599585,"about_ca_topic_score_gemma":0.00058799144,"teacher_disagreement_score":0.011179649,"about_ca_system_score_codex":0.00047976,"about_ca_system_score_gemma":0.00023446734,"threshold_uncertainty_score":0.03739965},"labels":[],"label_agreement":null},{"id":"W4398768432","doi":"10.1016/j.ejmech.2024.116533","title":"Design, synthesis and antiproliferative activity of raloxifene/histone deacetylase inhibitor hybrids in breast cancer","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Raloxifene; Chemistry; Histone deacetylase; Histone deacetylase inhibitor; Breast cancer; Cancer research; Tamoxifen; Pharmacology; Histone; Cancer; Internal medicine; Biochemistry; Gene","score_opus":0.013789920669580326,"score_gpt":0.29125233065277273,"score_spread":0.2774624099831924,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4398768432","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9745602,0.0036653823,0.0129943015,0.00016029424,0.000061271014,0.00027229392,0.0007851816,0.000208607,0.007292521],"genre_scores_gemma":[0.9836578,0.0013992665,0.0097704865,0.00008008475,0.000013091004,0.00014081821,0.00059415767,0.000024234068,0.0043201633],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999155,0.00001322473,0.0000066773605,0.000020545662,0.000023760014,0.00002036848],"domain_scores_gemma":[0.9999467,0.000006809733,0.000015651895,0.0000047520107,0.000013165873,0.0000130208255],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010373357,0.00024292622,0.00020829936,0.00020530501,0.00014220062,0.0002467906,0.00030008375,0.00031352942,0.0013456342],"category_scores_gemma":[0.00009438707,0.0001755093,0.0002587178,0.0001923929,0.000087263346,0.00019421648,0.00016262535,0.00031095956,0.00056091626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012593303,0.000056829685,0.00012812801,0.000090773145,0.000023585493,0.00009741686,0.00002665912,0.00056634017,0.9924555,0.00040106755,0.00012476917,0.005903098],"study_design_scores_gemma":[0.000040366995,0.00086143607,0.00092510704,0.000006648474,0.000058695383,0.00021998672,0.00002035582,0.00071239343,0.98821056,0.000050201135,0.008882531,0.000011698944],"about_ca_topic_score_codex":0.0003742101,"about_ca_topic_score_gemma":0.0006991662,"teacher_disagreement_score":0.0013456342,"about_ca_system_score_codex":0.0003194776,"about_ca_system_score_gemma":0.00012026944,"threshold_uncertainty_score":0.004501581},"labels":[],"label_agreement":null},{"id":"W4399053132","doi":"10.3389/fcell.2024.1368171","title":"Emerging role of HDAC11 in skeletal muscle biology","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"HDAC11; Biology; Histone; Epigenetics; Histone deacetylase; HDAC4; Histone deacetylase 5; Acetylation; Cell biology; Transcription factor; Promoter; Genetics; Gene; Gene expression","score_opus":0.004828998062832461,"score_gpt":0.2451183014829938,"score_spread":0.24028930342016133,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4399053132","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.028029447,0.93081677,0.0113921305,0.011378618,0.001216317,0.000024888133,0.00033471023,0.00016256457,0.016644605],"genre_scores_gemma":[0.17469779,0.8008122,0.007569755,0.003290363,0.0018810204,0.000053489748,0.00053604937,0.000027257252,0.0111321425],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998754,0.000017996319,0.000008064733,0.00003852202,0.000030366084,0.000029564768],"domain_scores_gemma":[0.99980956,0.000042870233,0.000026663349,0.000011259929,0.00005943973,0.000050137307],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005640728,0.00048447624,0.0005132273,0.0003631313,0.00020188713,0.001017854,0.00046823855,0.00079767726,0.002723819],"category_scores_gemma":[0.00026469422,0.0001782849,0.00032943336,0.0003455319,0.00080527406,0.0010555042,0.00050960394,0.0015249576,0.0010670156],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010370257,0.0001793648,0.004573735,0.0054282006,0.00017636556,0.001173789,0.00037458027,0.0013081806,0.31438857,0.07466501,0.022696715,0.5739984],"study_design_scores_gemma":[0.0001040359,0.00067303743,0.012917968,0.0006586354,0.00018337552,0.0022479245,0.0004271875,0.0020709492,0.068299375,0.030104702,0.8822495,0.00006329757],"about_ca_topic_score_codex":0.0004596784,"about_ca_topic_score_gemma":0.0010838293,"teacher_disagreement_score":0.002723819,"about_ca_system_score_codex":0.00062230875,"about_ca_system_score_gemma":0.0006585048,"threshold_uncertainty_score":0.00911206},"labels":[],"label_agreement":null},{"id":"W4399446748","doi":"10.1016/j.bbagrm.2024.195045","title":"HBO1, a MYSTerious KAT and its links to cancer","year":2024,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Biology; Histone methyltransferase; Histone H4; Cancer epigenetics; Histone H3; Cancer research; Histone; Histone H2A; Chromatin remodeling; Cell biology; Histone methylation; Acetylation; Genetics; DNA methylation; Gene; Gene expression","score_opus":0.03374841787841502,"score_gpt":0.3525146347418005,"score_spread":0.31876621686338547,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4399446748","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000051393425,0.99862504,0.000082948856,0.00031289292,0.00035994078,0.0000018148131,0.00001444497,0.000004341847,0.00054725684],"genre_scores_gemma":[0.00050426327,0.9977011,0.00010380544,0.00035139054,0.00043355286,0.000004832401,0.000040324292,0.0000014968296,0.0008592108],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.999871,0.000018192233,0.000014541756,0.000027270633,0.000049916292,0.000019040803],"domain_scores_gemma":[0.9998155,0.00008346101,0.000022793372,0.0000071802883,0.000044756827,0.000026289008],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000653652,0.0010041327,0.0011886485,0.0013922123,0.00032456176,0.0012838293,0.00087255915,0.0014792179,0.0028250595],"category_scores_gemma":[0.0007301126,0.0003718297,0.00029792864,0.0018466321,0.0010094619,0.0014761778,0.0007993893,0.0028287182,0.0024218583],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023813383,0.000073466836,0.00021075486,0.009468995,0.00008397364,0.00027393905,0.000055666886,0.00050532754,0.0024469,0.011803864,0.10002575,0.87481326],"study_design_scores_gemma":[0.000028239867,0.00004663948,0.00035430308,0.00083341816,0.00004689728,0.0004871593,0.000031614483,0.00005889455,0.00042807797,0.0032342835,0.99443793,0.000012461789],"about_ca_topic_score_codex":0.0011674978,"about_ca_topic_score_gemma":0.0022315928,"teacher_disagreement_score":0.0028250595,"about_ca_system_score_codex":0.00084742886,"about_ca_system_score_gemma":0.0010875304,"threshold_uncertainty_score":0.009450734},"labels":[],"label_agreement":null},{"id":"W4399771470","doi":"10.32920/26052754","title":"PIKfyve Inhibition Controls Inflammatory Gene Expression Networks and Activates TFEB via Oxidative Stress","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Oxidative stress; Cell biology; Gene expression; Gene; Biology; Genetics; Biochemistry","score_opus":0.007585140824751419,"score_gpt":0.2607945770550489,"score_spread":0.25320943623029746,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4399771470","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9806739,0.003936344,0.0067886445,0.00038171964,0.00019307618,0.000039151957,0.00259019,0.00052686856,0.004870029],"genre_scores_gemma":[0.9870194,0.0014528631,0.003403471,0.00013571294,0.000025295429,0.00006678347,0.0018838266,0.00010094606,0.0059116315],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998117,0.000013413892,0.000012084476,0.000051178435,0.00004083099,0.00007079152],"domain_scores_gemma":[0.99993944,0.000006652394,0.000015093485,0.0000074487793,0.000008571857,0.000022756903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011017317,0.00028377594,0.00040445972,0.00022580892,0.00017334585,0.000428046,0.00016198154,0.00028260873,0.0024898567],"category_scores_gemma":[0.00011588806,0.00013980434,0.00043193527,0.00017839816,0.00029987327,0.00026903246,0.00023190388,0.0007115063,0.00054419326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005282715,0.000029085122,0.00033704325,0.00006530654,0.000010089754,0.000048093774,0.000011836675,0.00007946218,0.99629444,0.000177681,0.00018413998,0.0022344706],"study_design_scores_gemma":[0.00003470998,0.00017299716,0.0065490617,0.0000066826387,0.00001961243,0.00012382228,0.000038762904,0.0008705309,0.98794156,0.00018264614,0.0040535773,0.000005947353],"about_ca_topic_score_codex":0.00055672444,"about_ca_topic_score_gemma":0.00079275627,"teacher_disagreement_score":0.0024898567,"about_ca_system_score_codex":0.00029848985,"about_ca_system_score_gemma":0.00026004334,"threshold_uncertainty_score":0.008329451},"labels":[],"label_agreement":null},{"id":"W4399771471","doi":"10.32920/26052754.v1","title":"PIKfyve Inhibition Controls Inflammatory Gene Expression Networks and Activates TFEB via Oxidative Stress","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Oxidative stress; Cell biology; TFEB; Gene expression; Inflammation; Chemistry; Gene; Cancer research; Biology; Immunology; Biochemistry; Transcription factor","score_opus":0.007585140824751419,"score_gpt":0.2607945770550489,"score_spread":0.25320943623029746,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4399771471","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9806739,0.003936344,0.0067886445,0.00038171964,0.00019307618,0.000039151957,0.00259019,0.00052686856,0.004870029],"genre_scores_gemma":[0.9870194,0.0014528631,0.003403471,0.00013571294,0.000025295429,0.00006678347,0.0018838266,0.00010094606,0.0059116315],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998117,0.000013413892,0.000012084476,0.000051178435,0.00004083099,0.00007079152],"domain_scores_gemma":[0.99993944,0.000006652394,0.000015093485,0.0000074487793,0.000008571857,0.000022756903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011017317,0.00028377594,0.00040445972,0.00022580892,0.00017334585,0.000428046,0.00016198154,0.00028260873,0.0024898567],"category_scores_gemma":[0.00011588806,0.00013980434,0.00043193527,0.00017839816,0.00029987327,0.00026903246,0.00023190388,0.0007115063,0.00054419326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005282715,0.000029085122,0.00033704325,0.00006530654,0.000010089754,0.000048093774,0.000011836675,0.00007946218,0.99629444,0.000177681,0.00018413998,0.0022344706],"study_design_scores_gemma":[0.00003470998,0.00017299716,0.0065490617,0.0000066826387,0.00001961243,0.00012382228,0.000038762904,0.0008705309,0.98794156,0.00018264614,0.0040535773,0.000005947353],"about_ca_topic_score_codex":0.00055672444,"about_ca_topic_score_gemma":0.00079275627,"teacher_disagreement_score":0.0024898567,"about_ca_system_score_codex":0.00029848985,"about_ca_system_score_gemma":0.00026004334,"threshold_uncertainty_score":0.008329451},"labels":[],"label_agreement":null},{"id":"W4399908080","doi":"10.1021/acs.jmedchem.4c00706","title":"Bifunctionality and Antitumor Efficacy of ZG-126, a Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Hybrid Molecule","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Calcitriol receptor; Chemistry; Histone deacetylase; Cancer research; Pharmacology; Agonist; Histone deacetylase inhibitor; In vivo; Melanoma; Nuclear receptor; Receptor; Biochemistry; Histone; Biology","score_opus":0.008835319042278704,"score_gpt":0.29325862485978016,"score_spread":0.28442330581750147,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4399908080","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99637955,0.000971868,0.00088941935,0.000036536123,0.000009023097,0.0000212951,0.00016941679,0.000029118526,0.0014939094],"genre_scores_gemma":[0.9979342,0.00037495384,0.0007603171,0.000014611289,0.0000025421068,0.000009114337,0.00015897256,0.000004395803,0.00074085547],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993634,0.000012537074,0.0000042667784,0.000010083473,0.000021388569,0.00001544739],"domain_scores_gemma":[0.99996793,0.0000053398808,0.000009812734,0.000003342272,0.0000038859653,0.000009715427],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009070002,0.00016946778,0.00012191915,0.00019281197,0.000074910204,0.00015570478,0.00011256915,0.00018094509,0.00069656345],"category_scores_gemma":[0.000064552856,0.000058211554,0.00011348213,0.00013700317,0.0001405061,0.00011144354,0.00009994165,0.0002486278,0.00014739255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020259462,0.00004995752,0.00013468196,0.000020575704,0.0000056720637,0.000012960448,0.0000065941126,0.0002401712,0.995814,0.00011060183,0.000042011558,0.0033601269],"study_design_scores_gemma":[0.00003445635,0.0010373686,0.0013799848,0.0000018579609,0.00001590113,0.000070824004,0.000005425619,0.0005863613,0.9958788,0.000017225586,0.0009689426,0.0000029515631],"about_ca_topic_score_codex":0.0004438954,"about_ca_topic_score_gemma":0.0005355199,"teacher_disagreement_score":0.00069656345,"about_ca_system_score_codex":0.00022440181,"about_ca_system_score_gemma":0.000102189675,"threshold_uncertainty_score":0.0023302436},"labels":[],"label_agreement":null},{"id":"W4400190355","doi":"10.1021/acs.jmedchem.4c00761","title":"Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Neurological Disorders and Stroke; Washington University School of Medicine in St. Louis; Florida Department of Health; National Institutes of Health; National Science Foundation","keywords":"HDAC8; Chemistry; HDAC3; Acetylation; Histone deacetylase; Biochemistry; Histone; Gene","score_opus":0.014299688986922677,"score_gpt":0.2631644869986211,"score_spread":0.24886479801169842,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400190355","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9440079,0.015434375,0.03207195,0.00066736864,0.00009096217,0.00024294126,0.00065698446,0.0002907737,0.0065368055],"genre_scores_gemma":[0.97812015,0.0054756743,0.012012136,0.00017249497,0.000038225087,0.000052846895,0.0006139401,0.000022638867,0.0034918291],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987817,0.000016370635,0.000010834828,0.000026337082,0.00004027977,0.000027920785],"domain_scores_gemma":[0.999936,0.000005005523,0.000019500545,0.0000090201465,0.000011352069,0.000019055991],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030727722,0.00037732127,0.00032812316,0.00013997976,0.00010716577,0.00034836755,0.00025043948,0.00033490252,0.000771784],"category_scores_gemma":[0.00012394895,0.00015110502,0.00024375752,0.00011854807,0.00019372637,0.00026537903,0.00026320395,0.000555459,0.00039884984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000121035315,0.000045652447,0.00027336774,0.000099382596,0.000015625947,0.00012015333,0.00002206682,0.00026356318,0.98954576,0.00045866062,0.00022007483,0.0088146785],"study_design_scores_gemma":[0.000049014143,0.0005890269,0.00089700875,0.000005596318,0.000019722649,0.00075415935,0.000015634176,0.00080589636,0.9887129,0.00006392936,0.008078747,0.000008415317],"about_ca_topic_score_codex":0.00025821288,"about_ca_topic_score_gemma":0.00048996194,"teacher_disagreement_score":0.000771784,"about_ca_system_score_codex":0.00036782864,"about_ca_system_score_gemma":0.00024041193,"threshold_uncertainty_score":0.0026688576},"labels":[],"label_agreement":null},{"id":"W4401090834","doi":"10.1002/advs.202401142","title":"HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ministry of Education and Child Care","funders":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","keywords":"Sensitivity (control systems); Function (biology); Medicine; Biology; Genetics; Engineering","score_opus":0.006702498251490014,"score_gpt":0.29996771947046097,"score_spread":0.293265221218971,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4401090834","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9697688,0.016809437,0.006841152,0.00043548187,0.00018718859,0.000106149586,0.00075999094,0.00024836615,0.0048434595],"genre_scores_gemma":[0.9889686,0.00449918,0.002207356,0.00010641415,0.000020427638,0.00003899912,0.000642222,0.000018290726,0.0034985687],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992025,0.000008321783,0.0000066116745,0.000016535769,0.00002567336,0.000022694894],"domain_scores_gemma":[0.9999758,0.000002399995,0.000007106469,0.0000029726054,0.000005973744,0.000005662703],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010576287,0.00024944267,0.00028666132,0.00013099531,0.00011839952,0.00021030697,0.00017600332,0.00019026887,0.0015074427],"category_scores_gemma":[0.00007272044,0.000101849575,0.00025228556,0.00011736201,0.00011546901,0.00013761867,0.0001058554,0.00039990174,0.0002932428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021599952,0.00006861259,0.000547074,0.00019532569,0.000020602081,0.000053866614,0.000017608825,0.00035678965,0.98657066,0.00024324932,0.0004381637,0.011272061],"study_design_scores_gemma":[0.00008468869,0.00073072,0.0047452757,0.000009590772,0.00005677526,0.00024616558,0.000028727365,0.0019378881,0.9778877,0.000076916614,0.014184602,0.000011040532],"about_ca_topic_score_codex":0.0007654323,"about_ca_topic_score_gemma":0.0025185356,"teacher_disagreement_score":0.0015074427,"about_ca_system_score_codex":0.00031377704,"about_ca_system_score_gemma":0.00020436168,"threshold_uncertainty_score":0.005042851},"labels":[],"label_agreement":null},{"id":"W4401295978","doi":"10.1093/noajnl/vdae090.132","title":"TRSC-04 DE NOVO GTP SYNTHESIS IS A METABOLIC VULNERABILITY FOR THE INTERCEPTION OF BRAIN METASTASES","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"In vivo; GTP'; Cancer research; De novo synthesis; Druggability; Biology; Pharmacology; Chemistry; Enzyme; Biochemistry; Gene; Genetics","score_opus":0.021428976634761548,"score_gpt":0.3653325293651381,"score_spread":0.34390355273037654,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4401295978","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96829224,0.004022028,0.015251288,0.000594171,0.00009775323,0.00007348793,0.0030375025,0.0008511756,0.007780438],"genre_scores_gemma":[0.9878542,0.001313429,0.003561824,0.000121729645,0.000007803944,0.000054878892,0.0026635085,0.000075066164,0.0043476587],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999254,0.0000071527666,0.0000034246605,0.000016606149,0.000029484108,0.000017960081],"domain_scores_gemma":[0.99992955,0.000009131281,0.000017324839,0.0000070307096,0.000016414626,0.000020611029],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007965683,0.00028433246,0.00024608662,0.00026420434,0.00021779284,0.00034639955,0.00020540389,0.0002845589,0.0026227443],"category_scores_gemma":[0.00013867592,0.00011578303,0.0002630183,0.00022483122,0.0002241948,0.00013151573,0.00022626389,0.00068217743,0.0006024629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011086328,0.000027833026,0.00052984117,0.00008462305,0.000013685851,0.00010051631,0.0000136800445,0.0004030959,0.99340737,0.0004156675,0.0004682052,0.00442461],"study_design_scores_gemma":[0.000026725374,0.0004503521,0.007118466,0.000023759909,0.000049042315,0.00079788105,0.00007625463,0.0042677694,0.97013277,0.0004985761,0.016543671,0.000014772898],"about_ca_topic_score_codex":0.0021855035,"about_ca_topic_score_gemma":0.003296205,"teacher_disagreement_score":0.0026227443,"about_ca_system_score_codex":0.0003610007,"about_ca_system_score_gemma":0.00031237985,"threshold_uncertainty_score":0.0087739825},"labels":[],"label_agreement":null},{"id":"W4401687825","doi":"10.1101/2024.08.18.608423","title":"The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; University Health Network","funders":"","keywords":"Antiprotozoal; Drug; Biology; Pharmacology; Genetics","score_opus":0.01104155348239622,"score_gpt":0.27406452789874874,"score_spread":0.26302297441635253,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4401687825","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96834093,0.013670732,0.0070773712,0.0014115985,0.00027736826,0.0000732939,0.0030588168,0.0007622025,0.005327668],"genre_scores_gemma":[0.98564607,0.0045447587,0.003796365,0.00031514416,0.000043107502,0.000044061813,0.0011489707,0.00005077862,0.004410613],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993527,0.000007713657,0.0000032120122,0.000011505971,0.000027837375,0.000014412836],"domain_scores_gemma":[0.99995005,0.0000059187323,0.000017071969,0.0000040512878,0.000006249752,0.000016714823],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010229497,0.0002530415,0.00019235015,0.00025080988,0.00009799085,0.00019658786,0.0001407648,0.00021103029,0.0026955954],"category_scores_gemma":[0.00007911073,0.00008553194,0.00020970307,0.00012696892,0.00018104727,0.00011103971,0.00012734078,0.00058245513,0.00037211605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00058379036,0.000058720845,0.0003493313,0.000090046575,0.000018497274,0.00004777387,0.000009139628,0.0000889499,0.98878443,0.0001789692,0.00057580636,0.009214488],"study_design_scores_gemma":[0.00015311332,0.0010526746,0.009784153,0.000017664364,0.00004083078,0.00028504926,0.000022808845,0.0005145798,0.9749244,0.00014262846,0.013053887,0.000008407958],"about_ca_topic_score_codex":0.0008001686,"about_ca_topic_score_gemma":0.0016617973,"teacher_disagreement_score":0.0026955954,"about_ca_system_score_codex":0.00023400618,"about_ca_system_score_gemma":0.00024294615,"threshold_uncertainty_score":0.009017646},"labels":[],"label_agreement":null},{"id":"W4402274272","doi":"10.1021/acsmedchemlett.4c00293","title":"Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10","year":2024,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Brookhaven National Laboratory; Biological and Environmental Research; Division of Chemistry; Office of Science; National Institute of General Medical Sciences; Vagelos Institute for Energy Science and Technology, University of Pennsylvania; Beef Cattle Research Council; University of Pennsylvania; U.S. Department of Energy; National Institutes of Health; National Science Foundation","keywords":"Acetylation; Computer science; Engineering ethics; Medicine; Combinatorial chemistry; Chemistry; Biochemistry; Engineering","score_opus":0.019260491405202168,"score_gpt":0.2987359585570099,"score_spread":0.2794754671518077,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402274272","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9693132,0.004986278,0.016936352,0.0002529261,0.00009550372,0.0007423285,0.0011011995,0.00018770563,0.006384429],"genre_scores_gemma":[0.9692833,0.006014365,0.01837211,0.00013724962,0.000025009369,0.00025548704,0.0011593484,0.000046000765,0.0047071367],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998691,0.000021764119,0.000015702799,0.000019757239,0.000040607247,0.000033025237],"domain_scores_gemma":[0.99989223,0.000011794012,0.000027893951,0.000008659664,0.000026132118,0.000033311444],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028264054,0.0005228773,0.00039639397,0.00023301497,0.00015846251,0.00027440785,0.00057391793,0.00029297092,0.0011704118],"category_scores_gemma":[0.00020598089,0.00024706958,0.00032448847,0.00022824343,0.00020059904,0.00019471082,0.00019089069,0.00056485506,0.00041391898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028994333,0.00017599693,0.0001707274,0.00013481946,0.000039736235,0.00013070977,0.00003494522,0.0019617174,0.9907603,0.00031415565,0.00018922417,0.005797659],"study_design_scores_gemma":[0.00022000511,0.0024262818,0.0007544016,0.000011078319,0.000062344116,0.00022987484,0.000023802575,0.0019605139,0.9886457,0.000045309353,0.005600876,0.000019854993],"about_ca_topic_score_codex":0.0011769207,"about_ca_topic_score_gemma":0.0031053338,"teacher_disagreement_score":0.0011769207,"about_ca_system_score_codex":0.0005786063,"about_ca_system_score_gemma":0.00038780223,"threshold_uncertainty_score":0.004198134},"labels":[],"label_agreement":null},{"id":"W4402551343","doi":"10.1158/1538-7445.pancreatic24-b082","title":"Abstract B082: Oncogenic KRAS-mediated epigenetic reprogramming is altered by loss of Activating Transcription Factor 3","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"Reprogramming; Epigenetics; KRAS; Transcription factor; Cancer research; Biology; Transcription (linguistics); Genetics; Cancer; Gene","score_opus":0.0570625945261774,"score_gpt":0.40504635020097446,"score_spread":0.34798375567479706,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402551343","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96221447,0.0022996597,0.00949974,0.0006188998,0.00032784557,0.0000605294,0.018504275,0.001178422,0.005296135],"genre_scores_gemma":[0.97013354,0.001008151,0.0024004942,0.00031344884,0.000028242828,0.000096914024,0.01160071,0.00029240726,0.014126138],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980825,0.000013312466,0.000012186417,0.00006319954,0.00005668835,0.000046413872],"domain_scores_gemma":[0.9998857,0.00000801312,0.00003733457,0.000011051243,0.000010331763,0.000047566333],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012203127,0.0003974218,0.000296175,0.0003595016,0.00027633726,0.00035156746,0.00025421457,0.00035401422,0.007976562],"category_scores_gemma":[0.00009207253,0.00014499242,0.00041953727,0.00028576195,0.0002527112,0.0001549283,0.0003090258,0.0007700466,0.0022173116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003313584,0.000019937685,0.00059281156,0.000054476277,0.000010833577,0.00012044403,0.000010336603,0.000050944767,0.99633044,0.00013288604,0.0005095014,0.0018360802],"study_design_scores_gemma":[0.00008994975,0.00030600314,0.03948822,0.000038468625,0.00006846606,0.0012978793,0.00010486807,0.0018498845,0.9355134,0.0003351098,0.020881051,0.00002659711],"about_ca_topic_score_codex":0.00085171737,"about_ca_topic_score_gemma":0.001016797,"teacher_disagreement_score":0.007976562,"about_ca_system_score_codex":0.00031980366,"about_ca_system_score_gemma":0.00023994388,"threshold_uncertainty_score":0.026684284},"labels":[],"label_agreement":null},{"id":"W4402762147","doi":"10.1007/s10014-024-00493-w","title":"Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma","year":2024,"lang":"en","type":"article","venue":"Brain Tumor Pathology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SickKids Foundation; University of British Columbia; Ottawa Hospital; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Curing Kids Cancer; Cure Starts Now Foundation","keywords":"Histone deacetylase; Glioma; Medicine; Neurology; Neurosurgery; Carbonic anhydrase; Cancer research; Pathology; Pharmacology; Histone; Chemistry; Biochemistry; Enzyme; Radiology","score_opus":0.007536261994977364,"score_gpt":0.2711580118906669,"score_spread":0.26362174989568954,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402762147","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98858553,0.0073611545,0.0011650348,0.00027320717,0.00014759295,0.00010050692,0.000305012,0.00017861695,0.0018833173],"genre_scores_gemma":[0.9932592,0.0038401287,0.00089376606,0.000048665588,0.000061910214,0.00006642187,0.0004814981,0.000026127953,0.0013222119],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987984,0.000018214389,0.0000064847927,0.000026003643,0.000022251937,0.000047235248],"domain_scores_gemma":[0.99992716,0.000011128337,0.0000136175695,0.000011967872,0.000004231577,0.000031961106],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022052013,0.00074438105,0.001165465,0.00053051836,0.00027556927,0.00033987628,0.0006448255,0.00040642428,0.0017377681],"category_scores_gemma":[0.00011156518,0.00019878983,0.0006257995,0.0005440976,0.0004909339,0.00049105956,0.00022279458,0.0012213512,0.0002594574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.03132427,0.003858371,0.0013670439,0.00050496287,0.00042268552,0.0007250691,0.000087725544,0.0010687332,0.8956523,0.0006426453,0.0013609536,0.062985174],"study_design_scores_gemma":[0.0063042487,0.10486592,0.021225363,0.000044342625,0.0011587169,0.0024702302,0.00015986114,0.0026866146,0.8471108,0.0006027742,0.013295705,0.0000753706],"about_ca_topic_score_codex":0.0017441316,"about_ca_topic_score_gemma":0.004987553,"teacher_disagreement_score":0.0017441316,"about_ca_system_score_codex":0.0004040695,"about_ca_system_score_gemma":0.0005837826,"threshold_uncertainty_score":0.00581342},"labels":[],"label_agreement":null},{"id":"W4402784533","doi":"10.1101/2024.09.23.614476","title":"Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; National Institutes of Health; Hospital for Sick Children; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre; Stand Up To Cancer; Ministério da Ciência, Tecnologia e Inovação; Genome British Columbia; Cancer Research UK; Government of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Government of Ontario; Fondation Brain Canada; Cancer Prevention and Research Institute of Texas; Genome Canada; Rally Foundation; University of Toronto; Canadian Institutes of Health Research; Pediatric Brain Tumor Foundation","keywords":"Medulloblastoma; Valproic Acid; Modulation (music); Cell biology; Chemistry; Cancer research; Neuroscience; Biology; Physics; Epilepsy","score_opus":0.006716420886977261,"score_gpt":0.22275908717831466,"score_spread":0.2160426662913374,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402784533","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9959337,0.0016989785,0.0011380834,0.000028161441,0.000012670849,0.000020903391,0.0004915541,0.00005754255,0.00061846676],"genre_scores_gemma":[0.99711585,0.00060031237,0.0009982351,0.0000115993025,0.000003125324,0.000022355129,0.0005071199,0.000009391879,0.00073203695],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999393,0.000009900492,0.0000068932786,0.000012338624,0.000020751522,0.000010744608],"domain_scores_gemma":[0.99995124,0.000008489182,0.000011200688,0.000005828979,0.000006818602,0.000016418911],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006580852,0.00023967269,0.00020645713,0.0002563601,0.00012488024,0.00018022448,0.00011220146,0.00011576878,0.00045586462],"category_scores_gemma":[0.000060060018,0.00006778376,0.00017663732,0.00012452684,0.00013688655,0.000125198,0.00015497321,0.00023233057,0.00011463893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007089634,0.000009476439,0.00017150921,0.000017003944,0.0000038821117,0.000036534635,0.000009499323,0.00003901283,0.99883157,0.000031144344,0.000015239127,0.0007642331],"study_design_scores_gemma":[0.000008697005,0.00019439742,0.006622052,0.0000034008885,0.0000126387995,0.00016949307,0.000030279258,0.0005510525,0.99091,0.000030296038,0.0014653219,0.0000023392672],"about_ca_topic_score_codex":0.0015726965,"about_ca_topic_score_gemma":0.0016398053,"teacher_disagreement_score":0.0015726965,"about_ca_system_score_codex":0.00032108554,"about_ca_system_score_gemma":0.00017183121,"threshold_uncertainty_score":0.0031270385},"labels":[],"label_agreement":null},{"id":"W4403090002","doi":"10.1200/jco.2022.40.16_suppl.6046","title":"Results of ACCURACY: A phase 2 trial of AL101, a selective gamma secretase inhibitor, in subjects with recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC) harboring Notch activating mutations (Notch <sup>mut</sup> ).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary; Juravinski Cancer Centre; Western University","funders":"","keywords":"Medicine; Notch signaling pathway; Adenoid cystic carcinoma; Gamma secretase; Pathology; Internal medicine; Cancer research; Oncology; Carcinoma; Receptor; Biology; Genetics","score_opus":0.07298259955231844,"score_gpt":0.42926732370340953,"score_spread":0.3562847241510911,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4403090002","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97950625,0.004978447,0.0008619559,0.0013895227,0.0003533965,0.0028991667,0.003584185,0.00031083668,0.006116174],"genre_scores_gemma":[0.9761179,0.0026051188,0.0026497445,0.002581446,0.00052736583,0.002587798,0.007881045,0.000084063664,0.0049655335],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99891293,0.00061260775,0.000059549133,0.00014331515,0.00010252495,0.00016906553],"domain_scores_gemma":[0.99839157,0.0003653197,0.0003556998,0.00014597028,0.00019413605,0.00054725364],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0036407267,0.0020086868,0.0020650388,0.0005579407,0.0004164919,0.0010668833,0.0010289385,0.0021278032,0.0052067246],"category_scores_gemma":[0.0020591207,0.0005984911,0.001294635,0.00042665377,0.0010391616,0.0013893275,0.00048076562,0.0030603167,0.0018815311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.8700777,0.024526926,0.00884912,0.00070994056,0.0016573289,0.00027619433,0.00034552225,0.0017406474,0.0146011375,0.00026487082,0.008217948,0.06873253],"study_design_scores_gemma":[0.6978546,0.27414298,0.016251441,0.000059003956,0.0012308493,0.00038060214,0.000061530314,0.0014480358,0.0021690016,0.00022415152,0.006130826,0.000046927926],"about_ca_topic_score_codex":0.00083021715,"about_ca_topic_score_gemma":0.0020577945,"teacher_disagreement_score":0.0052067246,"about_ca_system_score_codex":0.0008195794,"about_ca_system_score_gemma":0.0011967032,"threshold_uncertainty_score":0.019254208},"labels":[],"label_agreement":null},{"id":"W4403400294","doi":"10.3390/cancers16203454","title":"From Deworming to Cancer Therapy: Benzimidazoles in Hematological Malignancies","year":2024,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Penn State Hershey Cancer Institute; National Institutes of Health; Pennsylvania State University; National Cancer Institute; University of Pennsylvania","keywords":"Drug repositioning; Repurposing; Medicine; Drug; Deworming; Pharmacology; Cancer; Oncology; Cancer research; Bioinformatics; Biology; Internal medicine; Immunology","score_opus":0.06292998033394977,"score_gpt":0.3960345325005239,"score_spread":0.33310455216657414,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4403400294","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00017838657,0.9978593,0.00014508051,0.00035361506,0.00031429634,0.000005555678,0.00001426504,0.000013451597,0.0011160165],"genre_scores_gemma":[0.00094469596,0.99700373,0.00018410422,0.00041944103,0.00026168057,0.000006729584,0.00003107031,0.0000022858512,0.001146267],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998785,0.000020116502,0.000015004505,0.000021073833,0.00005145563,0.000013767201],"domain_scores_gemma":[0.999866,0.00005958583,0.000020715952,0.000004222426,0.000032729527,0.000016696627],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029190976,0.00064708147,0.00088368304,0.0016537919,0.00023271677,0.00065158645,0.0007352648,0.0008779061,0.0040180637],"category_scores_gemma":[0.00042014703,0.0001957667,0.0005167486,0.0012911747,0.0003759477,0.0010777767,0.0004923299,0.0021510955,0.0017510793],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000082674895,0.00007697047,0.00012267876,0.012048041,0.00007620691,0.00023773283,0.00005573391,0.00030703828,0.0022360936,0.0027493027,0.039713137,0.94229436],"study_design_scores_gemma":[0.000029918629,0.00014162803,0.0006417566,0.0026048897,0.00007949182,0.0014085473,0.000040600837,0.000092043876,0.0005752978,0.0016275219,0.99274534,0.000012856433],"about_ca_topic_score_codex":0.000806132,"about_ca_topic_score_gemma":0.0020824585,"teacher_disagreement_score":0.0040180637,"about_ca_system_score_codex":0.00047889008,"about_ca_system_score_gemma":0.0005403063,"threshold_uncertainty_score":0.013441801},"labels":[],"label_agreement":null},{"id":"W4404064319","doi":"10.1136/jitc-2024-sitc2024.0617","title":"617 Combined histone deacetylase and PD-L1 inhibition is safe and efficacious for the treatment of virus-associated cancers: results of a phase II clinical trial","year":2024,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Histone deacetylase; Histone deacetylase inhibitor; Medicine; Cancer research; Virology; Pharmacology; Chemistry; Histone; Biochemistry; Gene","score_opus":0.040241847453322425,"score_gpt":0.3652573165335079,"score_spread":0.32501546908018547,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404064319","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9890483,0.002595409,0.0007207669,0.00065446756,0.00012668082,0.004233826,0.000872368,0.000091361624,0.0016569048],"genre_scores_gemma":[0.9867176,0.0021200688,0.0022998997,0.0011499937,0.00023110294,0.004047978,0.0013985743,0.000039091934,0.0019956757],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99946195,0.00026222772,0.000033039818,0.000086451015,0.000055070643,0.00010138783],"domain_scores_gemma":[0.999288,0.00011774533,0.00013031739,0.00006315028,0.00003798885,0.00036282922],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0026561716,0.0012850576,0.0019627737,0.00042384048,0.00045422628,0.0010427927,0.0007809987,0.0016970388,0.0042552557],"category_scores_gemma":[0.00070964,0.0005774562,0.0014169491,0.00040711957,0.0012028454,0.0009951399,0.0004602287,0.0028974228,0.0008856762],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.8056757,0.07370234,0.0029935776,0.0007149911,0.0010727879,0.0002160966,0.00020650034,0.0013648415,0.04054981,0.0003295337,0.0029829207,0.070190914],"study_design_scores_gemma":[0.61554176,0.37518433,0.0033999048,0.000030523523,0.00029016833,0.00011515382,0.00003449864,0.0007690005,0.0026979826,0.00020620786,0.0017089659,0.00002149217],"about_ca_topic_score_codex":0.0006265709,"about_ca_topic_score_gemma":0.0013819042,"teacher_disagreement_score":0.0042552557,"about_ca_system_score_codex":0.0007642203,"about_ca_system_score_gemma":0.0014997785,"threshold_uncertainty_score":0.014235258},"labels":[],"label_agreement":null},{"id":"W4404064334","doi":"10.1136/jitc-2024-sitc2024.0575","title":"575 Epigenetic modulation by KDM6B in myeloid cells regulates glioblastoma immune checkpoint therapy outcomes","year":2024,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"University of Texas MD Anderson Cancer Center; Andrew Sabin Family Foundation","keywords":"Epigenetics; Glioblastoma; Cancer research; Epigenetic therapy; Immune checkpoint; Immune system; Medicine; DNA methylation; Immunotherapy; Biology; Gene; Immunology; Genetics; Gene expression","score_opus":0.008360031046056688,"score_gpt":0.24798554494770764,"score_spread":0.23962551390165096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404064334","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98265463,0.0035990037,0.0029020698,0.00032130396,0.00006409255,0.000041587893,0.0066792276,0.00018977466,0.0035484121],"genre_scores_gemma":[0.9886507,0.0013202488,0.0014696617,0.00030585326,0.000011432678,0.00006445972,0.0046497053,0.00007044117,0.0034576075],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986887,0.000007985233,0.000009285055,0.000034977595,0.00004283085,0.000036090107],"domain_scores_gemma":[0.99994063,0.000004913657,0.000021805148,0.0000043581363,0.000012769852,0.00001557773],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012142211,0.00013067295,0.00023649135,0.00017151904,0.00019822766,0.00036917342,0.00012358958,0.00021916187,0.003088056],"category_scores_gemma":[0.00013707032,0.00010605331,0.00024252171,0.0001574783,0.0001797011,0.00011896447,0.00023372407,0.00040353482,0.00069975783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005396231,0.000052657375,0.011702231,0.00018557612,0.000035837365,0.00006912254,0.00007227544,0.00044529582,0.97026855,0.00029817218,0.0014152026,0.014915458],"study_design_scores_gemma":[0.00009457721,0.00060313015,0.2926173,0.00008538866,0.00013767205,0.0005482787,0.00032898007,0.004388663,0.6732599,0.0005226892,0.027380269,0.000033164033],"about_ca_topic_score_codex":0.0014669738,"about_ca_topic_score_gemma":0.0032416433,"teacher_disagreement_score":0.003088056,"about_ca_system_score_codex":0.0003161975,"about_ca_system_score_gemma":0.0002693579,"threshold_uncertainty_score":0.010330558},"labels":[],"label_agreement":null},{"id":"W4404125770","doi":"10.1200/po.24.00328","title":"Updated Survival Follow-Up for Phase Ib Trial of the Histone Deacetylase Inhibitor Abexinostat With Pazopanib in Patients With Solid Tumor Malignancies","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Pazopanib; Histone deacetylase; Histone deacetylase inhibitor; Medicine; Internal medicine; Oncology; Cancer research; Pharmacology; Biology; Cancer; Histone; Genetics; Sunitinib","score_opus":0.01511728436312147,"score_gpt":0.3375026105248496,"score_spread":0.3223853261617281,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404125770","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98941433,0.0021185891,0.00080575043,0.00034498924,0.000060282662,0.00023942304,0.0039398186,0.00006153679,0.0030151508],"genre_scores_gemma":[0.9895007,0.00041310344,0.00072572957,0.00045188912,0.00004877969,0.00025894557,0.0076860944,0.000011967927,0.0009027226],"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.99954176,0.00014875212,0.000046332785,0.00010802571,0.00007730815,0.00007780964],"domain_scores_gemma":[0.99908686,0.00014449135,0.00031872746,0.00007065329,0.00008410931,0.00029523356],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013706359,0.00031458517,0.0009737928,0.00020727824,0.00036275724,0.0007021985,0.00022236738,0.00033966426,0.0012920838],"category_scores_gemma":[0.0009610101,0.0001247416,0.00070549065,0.00029071298,0.0001448393,0.0004487626,0.00029431554,0.00094859465,0.00029082914],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.16167665,0.0021240206,0.5796208,0.0005331119,0.0028249628,0.00040532,0.00022520882,0.0048547597,0.0287333,0.00044676437,0.008748331,0.20980678],"study_design_scores_gemma":[0.011866615,0.05608499,0.8995101,0.00010564939,0.0029956484,0.0010200606,0.000121528545,0.0041072783,0.008512544,0.00069650845,0.014930927,0.00004820698],"about_ca_topic_score_codex":0.0005219914,"about_ca_topic_score_gemma":0.001396671,"teacher_disagreement_score":0.0013706359,"about_ca_system_score_codex":0.0005229847,"about_ca_system_score_gemma":0.00046155349,"threshold_uncertainty_score":0.0072486997},"labels":[],"label_agreement":null},{"id":"W4404190898","doi":"10.1080/17501911.2024.2419357","title":"The Two Faces of HDAC3: Neuroinflammation in Disease and Neuroprotection in Recovery","year":2024,"lang":"en","type":"review","venue":"Epigenomics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Vancouver Coastal Health","funders":"BRAIN Foundation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Brain Foundation; Michael Smith Health Research BC","keywords":"Neuroprotection; Neuroinflammation; Neuroscience; HDAC3; Histone deacetylase; Biology; Disease; Regulator; Bioinformatics; Histone; Medicine; Immunology; Inflammation; Pathology; Gene; Genetics","score_opus":0.02177155710874948,"score_gpt":0.3306056264409337,"score_spread":0.30883406933218427,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404190898","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00014532462,0.99742717,0.00013224388,0.00071691396,0.00035562678,0.000003822398,0.00002341094,0.000009288414,0.0011860885],"genre_scores_gemma":[0.000813415,0.99724364,0.00017599817,0.000389721,0.00023246251,0.0000061255646,0.00003790065,0.0000021658323,0.0010985889],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99989724,0.000019125619,0.000015068887,0.000017753659,0.000035966405,0.00001490626],"domain_scores_gemma":[0.99986684,0.000050711962,0.000015873657,0.000004605412,0.000042025582,0.000019899167],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000358266,0.00062713097,0.0008603368,0.0011912738,0.00024350063,0.00087772956,0.00067857676,0.0010543278,0.0040788064],"category_scores_gemma":[0.0004219478,0.00019588826,0.00039647293,0.0011990144,0.00042180263,0.0012605896,0.00053027575,0.002052585,0.002040509],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001399074,0.00005439166,0.0001702599,0.01151521,0.00008208566,0.00021426387,0.00007585545,0.00022528556,0.0030205795,0.0076920134,0.044949237,0.93186086],"study_design_scores_gemma":[0.000019905152,0.000081811304,0.00059613667,0.0016942153,0.00005241099,0.0008654378,0.00005176601,0.0000546998,0.00045141455,0.0027145708,0.9934049,0.0000126445475],"about_ca_topic_score_codex":0.0007577199,"about_ca_topic_score_gemma":0.0020905333,"teacher_disagreement_score":0.0040788064,"about_ca_system_score_codex":0.0005808051,"about_ca_system_score_gemma":0.00083530636,"threshold_uncertainty_score":0.013644993},"labels":[],"label_agreement":null},{"id":"W4404612988","doi":"10.1007/s10126-024-10394-w","title":"Histone Modifications in the Anoxic Northern Crayfish, Faxonius virilis","year":2024,"lang":"en","type":"article","venue":"Marine Biotechnology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Crayfish; Anoxic waters; Drosophila virilis; Histone; Zoology; Ecology; Genetics; Gene; Drosophila melanogaster","score_opus":0.011787857601280302,"score_gpt":0.284605430144272,"score_spread":0.27281757254299166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404612988","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9990036,0.00015947138,0.000068458656,0.000015027074,0.0000033683646,0.0000018396172,0.00009941942,0.0000041134463,0.0006447114],"genre_scores_gemma":[0.9951292,0.00019191715,0.00018533181,0.00003064475,0.000004500804,0.0000045583074,0.00031339668,0.0000045210577,0.004135923],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99997413,0.0000012700269,0.0000017187543,0.000009247642,0.0000054783727,0.000008200008],"domain_scores_gemma":[0.9999248,0.000006248301,0.000022458846,0.0000050030662,0.000018359664,0.000023201863],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006656413,0.00016156552,0.00012808865,0.00028419154,0.00028601597,0.00018963387,0.00014338465,0.00019731536,0.0011523168],"category_scores_gemma":[0.00009664969,0.00012485632,0.0001161661,0.00014918148,0.00027158592,0.0001536913,0.00019383336,0.00023389616,0.00020459136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007318885,0.000018826158,0.012330559,0.000048053058,0.000015254323,0.00012964419,0.00016956717,0.00008023249,0.9835291,0.000101455014,0.000048560873,0.0027969556],"study_design_scores_gemma":[0.000042697207,0.0006631739,0.8618826,0.000010443782,0.000053682954,0.0005354322,0.000724732,0.00044476622,0.1328696,0.00013864062,0.0026182889,0.000015807056],"about_ca_topic_score_codex":0.013909134,"about_ca_topic_score_gemma":0.019940251,"teacher_disagreement_score":0.013909134,"about_ca_system_score_codex":0.00044333845,"about_ca_system_score_gemma":0.00024457302,"threshold_uncertainty_score":0.027656317},"labels":[],"label_agreement":null},{"id":"W4404916680","doi":"10.1371/journal.pone.0311691","title":"Blocking microtubule deacetylation inhibits anaphase chromosome movements in crane-fly spermatocytes","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Anaphase; Kinetochore; Cell biology; Microtubule; Biology; Chromosome segregation; Chemistry; Genetics; Chromosome","score_opus":0.028192240783557802,"score_gpt":0.26773942158922087,"score_spread":0.23954718080566306,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404916680","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9937901,0.0021109134,0.00078554323,0.00011062817,0.00005375701,0.000051760013,0.0007729446,0.00009719258,0.0022272738],"genre_scores_gemma":[0.9864364,0.0021762222,0.0015687031,0.00007813316,0.000016723186,0.000066936715,0.0012117687,0.000042322597,0.0084027825],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998672,0.000017756918,0.000018164339,0.00002890584,0.00003691645,0.000031064275],"domain_scores_gemma":[0.99983263,0.00003790646,0.00003668362,0.000019723839,0.000019939482,0.000053062377],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453666,0.00031086025,0.00033019867,0.00022879466,0.00019700556,0.0002775701,0.00037912407,0.00027346058,0.0021195626],"category_scores_gemma":[0.00013604685,0.00023789731,0.00029544372,0.00021113435,0.00020057072,0.0001352177,0.00016854506,0.0006225277,0.00045376303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019664082,0.000046258967,0.00015850036,0.000037814563,0.000010616776,0.000016129276,0.000016109934,0.0000619971,0.9984633,0.000042653774,0.000050917242,0.0008991114],"study_design_scores_gemma":[0.000059203616,0.0006877774,0.0071216505,0.000006687769,0.000022058308,0.000035273155,0.000024725912,0.0008132804,0.9884417,0.000016604497,0.0027663454,0.000004818646],"about_ca_topic_score_codex":0.0051741013,"about_ca_topic_score_gemma":0.0131864,"teacher_disagreement_score":0.0051741013,"about_ca_system_score_codex":0.0004112345,"about_ca_system_score_gemma":0.00040307117,"threshold_uncertainty_score":0.0102879405},"labels":[],"label_agreement":null},{"id":"W4405041955","doi":"10.1182/blood-2024-203960","title":"Examining the Clinical Relevance of the AML Plasma Metabolome","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Metabolome; Medicine; Internal medicine; Metabolite","score_opus":0.03586480585862123,"score_gpt":0.3264679816171502,"score_spread":0.29060317575852895,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405041955","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98990154,0.002644261,0.002715929,0.00055606785,0.000026293113,0.00003561399,0.0027465154,0.000049853086,0.0013239569],"genre_scores_gemma":[0.9940455,0.0008741348,0.0025632705,0.000188279,0.000047160196,0.000026923859,0.0019215659,0.000015905029,0.00031726557],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99967396,0.000075534066,0.000028783217,0.000108834436,0.00007079911,0.000042029413],"domain_scores_gemma":[0.99939334,0.00021956046,0.00018497999,0.000052983,0.00008722866,0.00006183492],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000618576,0.00029714176,0.00041101896,0.0007589405,0.00022562106,0.0008029561,0.00018402394,0.00033551082,0.0013332024],"category_scores_gemma":[0.0018671518,0.00011212039,0.0002935281,0.0008514378,0.00018312407,0.00033404093,0.00061957375,0.00046752408,0.00036180922],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016791475,0.00006211797,0.9090533,0.00016715597,0.00022221911,0.00038260175,0.00015470019,0.0011091032,0.038268443,0.00027089898,0.00089166977,0.047738507],"study_design_scores_gemma":[0.000034170018,0.00044459957,0.9751584,0.000050855237,0.0002165853,0.0012093413,0.0003240762,0.004906865,0.010964396,0.001406853,0.005258974,0.00002490542],"about_ca_topic_score_codex":0.0007795577,"about_ca_topic_score_gemma":0.0012559347,"teacher_disagreement_score":0.0013332024,"about_ca_system_score_codex":0.00026926855,"about_ca_system_score_gemma":0.00027498743,"threshold_uncertainty_score":0.0044600368},"labels":[],"label_agreement":null},{"id":"W4405049854","doi":"10.1182/blood-2024-193438","title":"UBE2E3 Supports Survival of Leukemia Stem Cells By Regulation of Polycomb Repression Complex (PRC) 1.1","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Psychological repression; Polycomb-group proteins; Stem cell; Leukemia; BMI1; Biology; Cancer research; Haematopoiesis; Repressor; Cell biology; Genetics; Gene; Transcription factor; Gene expression","score_opus":0.013556142941996691,"score_gpt":0.2683738063400698,"score_spread":0.2548176633980731,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405049854","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9850766,0.0029229482,0.0041780034,0.00031301274,0.000059267906,0.000031127915,0.0029609052,0.0005612702,0.0038968592],"genre_scores_gemma":[0.99328727,0.00046445668,0.0010413312,0.00007009687,0.0000062373006,0.000019638566,0.0020503642,0.00003943772,0.0030211997],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987316,0.000014018565,0.0000132393125,0.000029200708,0.00004576233,0.000024655821],"domain_scores_gemma":[0.99992454,0.000009089167,0.000022744654,0.000010614321,0.000013043431,0.000019932719],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011644936,0.0002940808,0.00026250273,0.00028669412,0.00022516587,0.0004287705,0.00020296605,0.00015761636,0.0019698744],"category_scores_gemma":[0.00014763096,0.000110432855,0.00025770254,0.00025946085,0.00020585151,0.00012108968,0.00035683418,0.0003392633,0.0005608933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016057712,0.000015792011,0.00082966377,0.000036200196,0.0000095205005,0.000036604,0.000010557527,0.000087670625,0.996626,0.00011811084,0.00019240296,0.0018767889],"study_design_scores_gemma":[0.000024928464,0.00010887215,0.022855572,0.000004793706,0.000024406025,0.00016613357,0.000028917577,0.0020812626,0.96734244,0.00010522093,0.007252124,0.0000052802175],"about_ca_topic_score_codex":0.0014164202,"about_ca_topic_score_gemma":0.003324952,"teacher_disagreement_score":0.0019698744,"about_ca_system_score_codex":0.0003639648,"about_ca_system_score_gemma":0.00025011782,"threshold_uncertainty_score":0.0065898895},"labels":[],"label_agreement":null},{"id":"W4405050368","doi":"10.1182/blood-2024-199315","title":"Infectious Complications and Antibiotic Prophylaxis during Induction Therapy with Venetoclax Plus Azacitidine for Previously Untreated AML: A Real-World Experience","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Venetoclax; Azacitidine; Medicine; Induction therapy; Antibiotics; Intensive care medicine; Leukemia; Internal medicine; Immunology; Oncology; Chemotherapy; Chronic lymphocytic leukemia; Microbiology; Biology","score_opus":0.01525518882374968,"score_gpt":0.28898036319444953,"score_spread":0.2737251743706999,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405050368","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99795014,0.0010141097,0.00017250792,0.00007560868,0.000007106644,0.000016000778,0.000019289106,0.0000037213413,0.00074147654],"genre_scores_gemma":[0.9986677,0.0008055335,0.00020517902,0.000072060066,0.00004639419,0.000007092721,0.00006311372,0.0000028035981,0.00013002765],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.999374,0.00024038611,0.00006785033,0.000073674586,0.00012617567,0.00011795631],"domain_scores_gemma":[0.99854493,0.0004374004,0.00039209906,0.00009627816,0.00007631498,0.00045295467],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00075740117,0.0002951484,0.00027892092,0.00035227166,0.0006441035,0.0007425425,0.00031827224,0.0005449662,0.00064866623],"category_scores_gemma":[0.0027039305,0.00020762619,0.0003080736,0.00039998695,0.00052479916,0.00033337856,0.0003931408,0.00061824213,0.00018315812],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010761842,0.0012702033,0.91467124,0.000076625925,0.00008178847,0.02452922,0.002044244,0.00041337335,0.0020538662,0.00015451325,0.00072146114,0.05290729],"study_design_scores_gemma":[0.0002840821,0.0074232444,0.8724378,0.000085701504,0.00012228733,0.11038466,0.0018356716,0.0011599854,0.0020550636,0.00017110177,0.0039820825,0.000058329035],"about_ca_topic_score_codex":0.0014330196,"about_ca_topic_score_gemma":0.002381034,"teacher_disagreement_score":0.0014330196,"about_ca_system_score_codex":0.00076883164,"about_ca_system_score_gemma":0.0006331837,"threshold_uncertainty_score":0.00557822},"labels":[],"label_agreement":null},{"id":"W4405126145","doi":"10.1182/blood-2024-205666","title":"A Phase 3 Randomized Trial for Patients with De Novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 with GO - a Report from the Children's Oncology Group","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children","funders":"Servier; Astellas Pharma; Syndax Pharmaceuticals; Incyte; Jazz Pharmaceuticals; Celgene","keywords":"Gemtuzumab ozogamicin; Medicine; Oncology; Internal medicine; Randomized controlled trial","score_opus":0.017494706870459512,"score_gpt":0.3249208257903451,"score_spread":0.3074261189198856,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405126145","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98007834,0.0020568217,0.00082362717,0.0020236266,0.0010413916,0.008909215,0.0019001794,0.00020435975,0.0029625716],"genre_scores_gemma":[0.9764213,0.0010539105,0.002648606,0.0027329086,0.0008122116,0.009873724,0.0020931207,0.00004169016,0.004322621],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99900407,0.00059297244,0.00004119606,0.00017250609,0.000054107477,0.00013518841],"domain_scores_gemma":[0.9979401,0.00062912813,0.00043236173,0.00018472123,0.00007924647,0.00073451275],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0028815863,0.0023757278,0.003015646,0.0005764068,0.00047361094,0.001224904,0.0012364838,0.0021960197,0.009108119],"category_scores_gemma":[0.0024018039,0.0007595059,0.0020982218,0.00047533656,0.0014774541,0.001424551,0.0006719685,0.004324466,0.0013153784],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.9897227,0.0038951964,0.00039051461,0.00010570725,0.00029629515,0.000023468703,0.000023327344,0.00020314122,0.0009886839,0.00009873035,0.000550058,0.0037020775],"study_design_scores_gemma":[0.9549144,0.04286736,0.000916191,0.000011865702,0.00014028593,0.0000226518,0.000009656633,0.00038495634,0.00016666393,0.00019691087,0.00036125572,0.0000077954355],"about_ca_topic_score_codex":0.00089737657,"about_ca_topic_score_gemma":0.0017198699,"teacher_disagreement_score":0.009108119,"about_ca_system_score_codex":0.0010878484,"about_ca_system_score_gemma":0.0018922448,"threshold_uncertainty_score":0.030469716},"labels":[],"label_agreement":null},{"id":"W4405248223","doi":"10.1101/2024.12.06.626451","title":"Chemical perturbations impacting histone acetylation govern colorectal cancer differentiation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Harvard Digestive Diseases Center, Harvard University; National Institutes of Health; Incyte; Genentech; U.S. Department of Defense; Colorectal Cancer Alliance; Dana-Farber/Harvard Cancer Center; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Servier; Amgen","keywords":"Epigenetics; Biology; HDAC1; Histone deacetylase 2; Histone deacetylase; Acetylation; Cancer research; Histone; Histone deacetylase 5; HDAC11; Cellular differentiation; Cancer epigenetics; Histone methyltransferase; Cell biology; Genetics; Gene","score_opus":0.010946345342570427,"score_gpt":0.26882827844874,"score_spread":0.2578819331061696,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405248223","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9841377,0.0019019354,0.006424198,0.0001514324,0.000058093523,0.000049736296,0.00097613904,0.0002132102,0.006087589],"genre_scores_gemma":[0.9902975,0.0012360243,0.0033889248,0.000056489833,0.0000073403216,0.000021972015,0.0005690871,0.000038943,0.004383619],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999263,0.0000070401,0.000004000082,0.000015987225,0.000027358472,0.0000192088],"domain_scores_gemma":[0.99997044,0.0000058713076,0.000009746652,0.0000041638414,0.0000035944056,0.00000619948],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009509355,0.00020214236,0.00014569562,0.000119187585,0.000114533825,0.00022131509,0.00013383196,0.00019206794,0.0012816113],"category_scores_gemma":[0.00008691214,0.00016364406,0.00015692638,0.000121638936,0.00016811842,0.00010195782,0.00012551573,0.00032289888,0.00043402892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000036218233,0.0000059805043,0.00009831721,0.000013490584,0.000002220363,0.000010540047,0.0000024206001,0.000075568045,0.9989121,0.000072954244,0.000030660078,0.0007396067],"study_design_scores_gemma":[0.000004440894,0.000049579357,0.000882213,8.9888067e-7,0.000004012308,0.000032526317,0.0000032771936,0.0004954979,0.99752337,0.000028922472,0.00097388466,0.0000014506084],"about_ca_topic_score_codex":0.0007769761,"about_ca_topic_score_gemma":0.0018436786,"teacher_disagreement_score":0.0012816113,"about_ca_system_score_codex":0.0003354371,"about_ca_system_score_gemma":0.00017677007,"threshold_uncertainty_score":0.0042874217},"labels":[],"label_agreement":null},{"id":"W4405289266","doi":"10.14740/wjon1944","title":"<i>ACTR10</i> Overexpression Facilitates the Progression and Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma","year":2024,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"Medicine; Hepatocellular carcinoma; Tyrosine-kinase inhibitor; Cancer research; Tyrosine kinase; Kinase; Acquired resistance; Internal medicine; Oncology; Cancer; Receptor; Cell biology; Biology","score_opus":0.013332355586359791,"score_gpt":0.3029305979613803,"score_spread":0.28959824237502046,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405289266","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98767555,0.0016780803,0.0041877464,0.00018347378,0.000023329856,0.00003971264,0.0040156567,0.00044330314,0.0017531926],"genre_scores_gemma":[0.989153,0.00089683564,0.003148119,0.00010528974,0.000013025544,0.000053859527,0.0059634983,0.00003809885,0.000628406],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996619,0.000053382093,0.00002854121,0.00008447752,0.00012512002,0.000046463323],"domain_scores_gemma":[0.9994981,0.00012639465,0.00021183498,0.00004576707,0.00006307242,0.00005487441],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00051157206,0.0002912942,0.00046997063,0.0007926075,0.00018220652,0.000620098,0.00021288755,0.00020724327,0.001982446],"category_scores_gemma":[0.0006174969,0.00012314315,0.0004294999,0.00078556786,0.00022447757,0.00018036374,0.00023941394,0.00042333358,0.000671464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0027921489,0.00032874788,0.22661713,0.0005709707,0.0004325241,0.00060947146,0.00007286572,0.0040464518,0.712519,0.00029323413,0.0026602424,0.049057204],"study_design_scores_gemma":[0.000043659475,0.0008821387,0.77498364,0.000046120585,0.0003585624,0.0026461396,0.00019000094,0.014627817,0.19958933,0.00032398355,0.0062669585,0.000041630414],"about_ca_topic_score_codex":0.0016197885,"about_ca_topic_score_gemma":0.0024020907,"teacher_disagreement_score":0.001982446,"about_ca_system_score_codex":0.00041791194,"about_ca_system_score_gemma":0.00036617846,"threshold_uncertainty_score":0.0066319704},"labels":[],"label_agreement":null},{"id":"W4405428849","doi":"10.1021/acs.jmedchem.4c01673","title":"Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Rogel Cancer Center, University of Michigan; National Cancer Institute; National Institutes of Health; University of Toronto; Leukemia and Lymphoma Society; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Chemistry; Cancer research; Biochemistry; Biology","score_opus":0.013051431583224938,"score_gpt":0.2921364184775918,"score_spread":0.2790849868943669,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405428849","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9340123,0.011969507,0.031198401,0.0008172554,0.00021209245,0.00065972976,0.0014516512,0.0005726024,0.019106451],"genre_scores_gemma":[0.9715674,0.0073981592,0.012300679,0.0003198889,0.000029274686,0.00015500537,0.00086772454,0.000019782005,0.007342074],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994814,0.000008004426,0.000004070217,0.000009771889,0.0000132844225,0.000016807358],"domain_scores_gemma":[0.9999752,0.000002430455,0.000007436,0.0000022937663,0.0000041202125,0.000008508165],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016083034,0.00038399012,0.00025296214,0.00018901342,0.0001041002,0.00015314945,0.00035147546,0.00022781729,0.0020616024],"category_scores_gemma":[0.00008381865,0.0001630256,0.00018782911,0.00015257836,0.00014656622,0.00023851692,0.0002414353,0.000510524,0.0005516273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042694135,0.0003337694,0.00020398498,0.00046001087,0.000027402817,0.00027650959,0.000065677414,0.0043946817,0.96449107,0.0018574921,0.00084352464,0.026619028],"study_design_scores_gemma":[0.0008947319,0.007805914,0.0021903913,0.00006798694,0.00007492041,0.0007512952,0.000053360964,0.011115479,0.94629383,0.00066633587,0.030029869,0.000055885823],"about_ca_topic_score_codex":0.00024253187,"about_ca_topic_score_gemma":0.0007929349,"teacher_disagreement_score":0.0020616024,"about_ca_system_score_codex":0.0002351385,"about_ca_system_score_gemma":0.00023891933,"threshold_uncertainty_score":0.0068967342},"labels":[],"label_agreement":null},{"id":"W4405743547","doi":"10.1016/j.intimp.2024.113927","title":"c-JUN interacts with HDAC1 as a potential combinatorial therapeutic target in acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; University of Science and Technology of China; National Natural Science Foundation of China","keywords":"Myeloid leukemia; Cancer research; Immunology; Leukemia; Medicine; Biology","score_opus":0.005765484800436759,"score_gpt":0.3088271962603959,"score_spread":0.30306171145995914,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405743547","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9767727,0.013639354,0.0025760974,0.0004511574,0.00019372198,0.00008997781,0.00037150198,0.00013549534,0.0057700253],"genre_scores_gemma":[0.9918996,0.003928639,0.0014515837,0.00010806675,0.00004315406,0.00004526338,0.00034782404,0.000012287803,0.0021634859],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999013,0.000012562176,0.00000570748,0.000016537886,0.00002919994,0.000034696863],"domain_scores_gemma":[0.9999645,0.0000036522374,0.000009137724,0.000003884818,0.0000048211696,0.000014043503],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018408711,0.0003011947,0.00033342748,0.00019194525,0.00022239474,0.0003697523,0.00037231526,0.00017099567,0.0014915236],"category_scores_gemma":[0.00007638312,0.00012068542,0.00022830523,0.0002720197,0.00016317396,0.00015233297,0.00023717918,0.0006856991,0.00038655248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016933872,0.00043160413,0.0015960006,0.00030240507,0.00008453659,0.000117905365,0.00002589042,0.00081243867,0.95477325,0.00083319726,0.0010149094,0.03831449],"study_design_scores_gemma":[0.00053678436,0.003280926,0.010852906,0.000028841037,0.0003279312,0.0008356864,0.00009715497,0.003940257,0.95057297,0.00038326025,0.029123826,0.000019365025],"about_ca_topic_score_codex":0.00028280416,"about_ca_topic_score_gemma":0.0011097589,"teacher_disagreement_score":0.0014915236,"about_ca_system_score_codex":0.00038419923,"about_ca_system_score_gemma":0.00028494603,"threshold_uncertainty_score":0.004989624},"labels":[],"label_agreement":null},{"id":"W4405835659","doi":"10.1016/j.ejmech.2024.117208","title":"Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Universiteit Gent; Vlaamse regering; University of Toronto; Fonds Wetenschappelijk Onderzoek","keywords":"Chemistry; Zinc finger; Ubiquitin; Biochemistry; Cell biology; Transcription factor; Gene","score_opus":0.017915205659183815,"score_gpt":0.25447417654020266,"score_spread":0.23655897088101885,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405835659","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93320256,0.020613322,0.026247803,0.00052411377,0.0002126465,0.0014085406,0.0051665683,0.00056152296,0.012062988],"genre_scores_gemma":[0.9598477,0.011780188,0.0146292085,0.00020220802,0.00003876581,0.0002641458,0.0051297597,0.000040852963,0.008067128],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988663,0.000012104114,0.00000904394,0.000019198622,0.00003692407,0.000035990142],"domain_scores_gemma":[0.9999447,0.0000066054586,0.00001100207,0.0000046012224,0.000014367533,0.000018678813],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028676083,0.0007639679,0.00061737455,0.0004481291,0.0002601475,0.00027781556,0.0006387962,0.0003621101,0.002628107],"category_scores_gemma":[0.00014705381,0.00024627981,0.000476976,0.00034146328,0.00015566914,0.00024295542,0.00020148675,0.000566567,0.000752655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006617924,0.0005239297,0.0003000988,0.00038115005,0.00010320315,0.000286764,0.000032505017,0.0024865652,0.9701025,0.00065241987,0.0010373576,0.02343177],"study_design_scores_gemma":[0.00073813123,0.0035598408,0.0015423478,0.00002964919,0.00021482371,0.000826124,0.000028996083,0.0033678224,0.9695598,0.00014110735,0.019959915,0.000031481643],"about_ca_topic_score_codex":0.0009383148,"about_ca_topic_score_gemma":0.0019793042,"teacher_disagreement_score":0.002628107,"about_ca_system_score_codex":0.00046801817,"about_ca_system_score_gemma":0.00040136566,"threshold_uncertainty_score":0.0087919235},"labels":[],"label_agreement":null},{"id":"W4406119011","doi":"10.3390/cells14020072","title":"Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Garron Family Cancer Centre; National Institutes of Health; Genome Canada; Hospital de Clínicas de Porto Alegre; University of Toronto; Ministério da Ciência, Tecnologia e Inovação; Brain Tumour Charity; Cancer Research UK; Stand Up To Cancer; Hospital for Sick Children; Genome British Columbia; Government of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Government of Ontario; V Foundation for Cancer Research; Brain Tumour Foundation of Canada; Fondation Brain Canada; Swifty Foundation; Rally Foundation; Canadian Cancer Society Research Institute; Matthew Larson Foundation for Pediatric Brain Tumors; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Prevention and Research Institute of Texas; C.R. Younger Foundation; Pediatric Brain Tumor Foundation","keywords":"Neurosphere; Biology; Acetylation; Medulloblastoma; Histone; Epigenetics; Cancer research; Valproic Acid; Cellular differentiation; Histone deacetylase; Cell biology; Genetics; Epilepsy; Gene; Neuroscience; Adult stem cell","score_opus":0.0033911145271770045,"score_gpt":0.23255412159158692,"score_spread":0.22916300706440992,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4406119011","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9962004,0.0018905234,0.000953554,0.000027941029,0.000010523651,0.000015266154,0.0003816699,0.000041788102,0.0004783937],"genre_scores_gemma":[0.9969715,0.0009006344,0.0009813654,0.0000134950615,0.000003395864,0.000020249989,0.0004814096,0.000009607104,0.0006182085],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994147,0.000009669325,0.000007208996,0.000012854907,0.000018604422,0.00001028114],"domain_scores_gemma":[0.9999635,0.0000059421927,0.000009784369,0.0000047020603,0.000004504036,0.000011524779],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006037332,0.00021258289,0.00019443031,0.00022154964,0.0001154088,0.00018183321,0.0001036855,0.000109630724,0.00033963693],"category_scores_gemma":[0.00005960374,0.00007157474,0.00018437748,0.00011578191,0.0001369376,0.00013565214,0.00013457623,0.00022446517,0.00009509391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006601466,0.00000837734,0.00015836427,0.000014835581,0.0000038525677,0.00003200149,0.0000093063945,0.00003801786,0.9988978,0.00003129481,0.000011370962,0.0007288196],"study_design_scores_gemma":[0.000009112811,0.00017009143,0.006872164,0.0000027287717,0.0000126728,0.00014509575,0.00002763895,0.00047438694,0.9908922,0.00003322144,0.0013582776,0.0000024202245],"about_ca_topic_score_codex":0.0015816236,"about_ca_topic_score_gemma":0.0018089757,"teacher_disagreement_score":0.0015816236,"about_ca_system_score_codex":0.0003119715,"about_ca_system_score_gemma":0.0001835695,"threshold_uncertainty_score":0.0031448007},"labels":[],"label_agreement":null},{"id":"W4407306965","doi":"10.1182/bloodadvances.2024015176","title":"Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Nivolumab; Medicine; Clinical endpoint; Internal medicine; Adverse effect; Randomized controlled trial; Phases of clinical research; Progressive disease; Oncology; Surgery; Chemotherapy; Gastroenterology; Cancer; Immunotherapy","score_opus":0.012071033307761802,"score_gpt":0.33146551756274606,"score_spread":0.31939448425498423,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4407306965","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9893071,0.0015106775,0.0009248202,0.0004976648,0.00026595683,0.005728324,0.0008865752,0.00008414832,0.0007948171],"genre_scores_gemma":[0.9829405,0.00093767827,0.0039434987,0.0012033209,0.000318418,0.007508476,0.001293107,0.000027129772,0.0018279437],"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","domain_scores_codex":[0.99913776,0.00056735566,0.000041985404,0.0001115599,0.000057601028,0.000083648585],"domain_scores_gemma":[0.9989386,0.00027213068,0.00023775827,0.000117337106,0.00008551334,0.00034860958],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0030370827,0.0012688508,0.0022165184,0.00031335675,0.00043398878,0.00067413977,0.000858476,0.0014714011,0.005315275],"category_scores_gemma":[0.001753019,0.0006213425,0.0010613909,0.00027986654,0.0007846974,0.00079618423,0.00034411214,0.0021553698,0.00072676345],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.9430818,0.021179197,0.0020368902,0.00041386473,0.0007957969,0.000073963485,0.000050492326,0.0005036822,0.008522689,0.0001200294,0.001021273,0.022200353],"study_design_scores_gemma":[0.9025869,0.09407516,0.001552568,0.000011234131,0.00020553388,0.000037822272,0.000007235917,0.00038716636,0.0005407531,0.00006283386,0.0005254547,0.000007414495],"about_ca_topic_score_codex":0.00047261716,"about_ca_topic_score_gemma":0.0014200419,"teacher_disagreement_score":0.005315275,"about_ca_system_score_codex":0.0007136511,"about_ca_system_score_gemma":0.0017835406,"threshold_uncertainty_score":0.017781377},"labels":[],"label_agreement":null},{"id":"W4408221171","doi":"10.1016/j.esmoop.2025.104221","title":"61P Targeting ATR and PKMYT1 to overcome carboplatin resistance in triple-negative breast cancer patient-derived models","year":2025,"lang":"en","type":"article","venue":"ESMO Open","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Occupational Cancer Research Centre; Jewish General Hospital","funders":"","keywords":"Triple-negative breast cancer; Carboplatin; Breast cancer; Medicine; Triple negative; Oncology; Cancer; Internal medicine; Cancer research; Chemotherapy; Cisplatin","score_opus":0.011635760681426398,"score_gpt":0.3053877772091159,"score_spread":0.2937520165276895,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4408221171","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97208744,0.002270676,0.0083119245,0.0017518876,0.00034555866,0.00029066255,0.005245198,0.0005518258,0.009144778],"genre_scores_gemma":[0.9792737,0.0015675938,0.0035130556,0.00021839514,0.000025943165,0.00023960543,0.0027163222,0.00010833079,0.012337032],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99968684,0.00004176839,0.000023968076,0.00006454178,0.00010345646,0.00007950049],"domain_scores_gemma":[0.9998759,0.000018589883,0.000030852472,0.000024375797,0.000009853898,0.000040327224],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003532826,0.0004714329,0.00048637058,0.00053175667,0.0003305543,0.00074192433,0.00065030286,0.00093593454,0.0043287966],"category_scores_gemma":[0.00016346501,0.00034840542,0.0005786328,0.00032049866,0.00047733894,0.00036111602,0.00032217134,0.0026597676,0.0012467233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00092057534,0.00047448772,0.00030701197,0.0000977754,0.000044082008,0.00029680185,0.00007792243,0.001182081,0.9854896,0.002101409,0.0017933435,0.007214882],"study_design_scores_gemma":[0.00046667468,0.0022947225,0.0028212706,0.000028758932,0.00010139714,0.0014484101,0.00013505605,0.0060158554,0.9615548,0.00055749796,0.024552437,0.000023002602],"about_ca_topic_score_codex":0.0014636144,"about_ca_topic_score_gemma":0.0021103756,"teacher_disagreement_score":0.0043287966,"about_ca_system_score_codex":0.0009055832,"about_ca_system_score_gemma":0.0005988634,"threshold_uncertainty_score":0.0144812465},"labels":[],"label_agreement":null},{"id":"W4408873161","doi":"10.1038/s41589-025-01869-5","title":"Reversible histone deacetylase activity catalyzes lysine acylation","year":2025,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute on Aging; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; University of California, San Francisco; U.S. Department of Health and Human Services","keywords":"Acylation; Lysine; Chemistry; Histone deacetylase; Acetylation; Histone; Histone deacetylase 5; HDAC11; Biochemistry; Histone deacetylase 2; Computational biology; Cell biology; Biology; Amino acid; Catalysis; DNA","score_opus":0.005859235197974469,"score_gpt":0.32286630419402673,"score_spread":0.31700706899605224,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4408873161","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.78877866,0.019340038,0.12780184,0.0017349704,0.0017632284,0.00044658608,0.0020886562,0.0029742098,0.055071924],"genre_scores_gemma":[0.96943,0.004363485,0.008290602,0.00013522604,0.00010691497,0.000050453807,0.0010357457,0.00008011174,0.016507441],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996692,0.000030122237,0.00001731927,0.00009865518,0.00011056508,0.000074213676],"domain_scores_gemma":[0.9998803,0.000022189879,0.000029915838,0.000024355317,0.00001800305,0.000025194666],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038595998,0.0006653633,0.00032881647,0.00030514318,0.00032298814,0.0004797836,0.00079826923,0.00034817014,0.00427073],"category_scores_gemma":[0.00027765348,0.0003536845,0.00041978376,0.00027463294,0.00041573326,0.00046016768,0.000593741,0.0011672137,0.0017458908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020871783,0.00007505656,0.00034004552,0.00020334753,0.00004851958,0.000105508094,0.00002953233,0.00026379878,0.977042,0.0033947395,0.00059750065,0.017691191],"study_design_scores_gemma":[0.000010650716,0.00006744838,0.00016866831,0.0000023028097,0.000009265174,0.00004369213,0.0000037392376,0.0001516703,0.9955629,0.00009270094,0.0038826915,0.000004264743],"about_ca_topic_score_codex":0.0012162756,"about_ca_topic_score_gemma":0.0023521148,"teacher_disagreement_score":0.00427073,"about_ca_system_score_codex":0.00086226343,"about_ca_system_score_gemma":0.00053582725,"threshold_uncertainty_score":0.014286995},"labels":[],"label_agreement":null},{"id":"W4409116605","doi":"10.21203/rs.3.rs-6208718/v1","title":"Abacavir enhances the efficacy of Doxorubicin via inhibition of histone demethylase KDM5B in breast cancer","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Demethylase; Doxorubicin; Abacavir; Breast cancer; Cancer research; Chemistry; Oncology; Histone; Internal medicine; Biology; Medicine; Cancer; Genetics; Chemotherapy; Biochemistry","score_opus":0.02532553981989624,"score_gpt":0.4174991076919792,"score_spread":0.39217356787208296,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4409116605","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9831041,0.010127041,0.0010824809,0.0005256616,0.00035637105,0.0000578793,0.00064871274,0.0002317255,0.0038660641],"genre_scores_gemma":[0.9946956,0.0020896161,0.0006988262,0.00007646549,0.000052621715,0.000030032543,0.00047122213,0.000025413774,0.0018601879],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998907,0.000028619379,0.000007504272,0.000017593542,0.000018893681,0.00003660251],"domain_scores_gemma":[0.9999367,0.000018019819,0.000009081775,0.000011354449,0.0000064601,0.000018469256],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022884397,0.00025836632,0.00053111615,0.0002065735,0.00013649333,0.00040235708,0.00028793802,0.00031983995,0.004555396],"category_scores_gemma":[0.00028065188,0.00015736047,0.000295486,0.00014872882,0.0001864964,0.00029113097,0.00013660296,0.00079605565,0.0005578835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.01532968,0.0013938419,0.0011890918,0.0004032346,0.00013149939,0.00014429772,0.0000485881,0.0011173994,0.89310807,0.000908958,0.0028725069,0.08335277],"study_design_scores_gemma":[0.002555378,0.014486635,0.016442724,0.000050404997,0.0003898391,0.0006836704,0.00007627341,0.0058543663,0.9394201,0.0005561058,0.019448444,0.000036228852],"about_ca_topic_score_codex":0.00044346147,"about_ca_topic_score_gemma":0.0006710827,"teacher_disagreement_score":0.004555396,"about_ca_system_score_codex":0.00026391633,"about_ca_system_score_gemma":0.0002571312,"threshold_uncertainty_score":0.015239358},"labels":[],"label_agreement":null},{"id":"W4409148163","doi":"10.1038/s41467-025-58350-z","title":"Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Innovative Medicines Initiative; European Commission; European Federation of Pharmaceutical Industries and Associations; Gedeon Richter; McGill University; Diamond Light Source; Cancer Research UK; Wellcome Trust","keywords":"HDAC1; Ubiquitin ligase; Cell biology; Mutant; Biology; Ternary complex; Mutation; DNA ligase; Histone deacetylase; Ubiquitin; Histone; Genetics; Biochemistry; Gene","score_opus":0.05249541949840753,"score_gpt":0.42452047668208714,"score_spread":0.3720250571836796,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4409148163","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99519485,0.00044182118,0.0026348468,0.000083401945,0.000025923597,0.000010520081,0.00018709098,0.00010618968,0.0013153318],"genre_scores_gemma":[0.9950665,0.0002221904,0.0029293033,0.000046029592,0.0000021036522,0.000017104245,0.0003080425,0.000042769687,0.0013658957],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989295,0.000014660269,0.000006723248,0.000024174478,0.000031575502,0.000029993778],"domain_scores_gemma":[0.99992514,0.000012140813,0.00002559538,0.000011731848,0.0000064621263,0.000018952045],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009190419,0.00031076156,0.0001972847,0.00012895706,0.0001795129,0.00022960256,0.00040017004,0.00039962985,0.0023489986],"category_scores_gemma":[0.00014308949,0.00022342702,0.00028238035,0.000121419216,0.0002939622,0.00021583351,0.00034699382,0.00052339764,0.00039791063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012258961,0.00001426821,0.00044712692,0.000034019966,0.000013449879,0.0001679875,0.000016530164,0.00054911367,0.9974131,0.00024318599,0.00009738359,0.0008812625],"study_design_scores_gemma":[0.000014304282,0.00009321624,0.0019868158,0.0000044568924,0.000010445604,0.00042991602,0.00003376651,0.0024136936,0.9927362,0.000054522872,0.0022172125,0.000005450974],"about_ca_topic_score_codex":0.00079971354,"about_ca_topic_score_gemma":0.00091524917,"teacher_disagreement_score":0.0023489986,"about_ca_system_score_codex":0.00042131377,"about_ca_system_score_gemma":0.00016509663,"threshold_uncertainty_score":0.007858157},"labels":[],"label_agreement":null},{"id":"W4409715710","doi":"10.1016/j.joca.2025.02.069","title":"Identification of Epigenetic Markers associated with Recovery from Pain Following Surgical Intervention for Lumbar Spinal Stenosis due to Spine Osteoarthritis","year":2025,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Krembil Foundation; Arthritis Society; McGill University; University Health Network","funders":"","keywords":"Medicine; Osteoarthritis; Spinal stenosis; Lumbar spinal stenosis; Back pain; Intervention (counseling); Identification (biology); Lumbar; Physical therapy; Physical medicine and rehabilitation; Surgery; Pathology; Biology; Psychiatry; Alternative medicine","score_opus":0.005464067554763349,"score_gpt":0.2507635874667042,"score_spread":0.24529951991194082,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4409715710","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99853754,0.00076113193,0.00026132067,0.000042177147,0.0000071681425,0.000005668629,0.00010742472,0.000004132271,0.00027345252],"genre_scores_gemma":[0.9988667,0.00025842074,0.0002289688,0.000032605763,0.000008648175,0.0000074721547,0.00014743843,0.0000017874315,0.0004480141],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9999099,0.000013947827,0.0000075550847,0.000021068485,0.000022714148,0.000024769643],"domain_scores_gemma":[0.9996973,0.00005207086,0.00017406534,0.000009705974,0.000036583355,0.000030193205],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012727377,0.00010671993,0.00022502166,0.00041456442,0.00015402492,0.00024614835,0.0001329822,0.00020627138,0.00097171677],"category_scores_gemma":[0.00062833354,0.000084437735,0.00016555724,0.00037409615,0.00015042849,0.00008972407,0.00013617183,0.00022013801,0.00009942256],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003949961,0.00043262556,0.6949096,0.00022522367,0.0003701417,0.00068817165,0.00035824472,0.00019059096,0.25324216,0.0001680303,0.00030230416,0.045162916],"study_design_scores_gemma":[0.000010979745,0.00026726243,0.99491286,0.000007142517,0.00006006145,0.00024178995,0.000112172325,0.00017174131,0.003955629,0.000036206755,0.00022007606,0.0000039725173],"about_ca_topic_score_codex":0.0009485851,"about_ca_topic_score_gemma":0.0021703711,"teacher_disagreement_score":0.00097171677,"about_ca_system_score_codex":0.00013484366,"about_ca_system_score_gemma":0.00013840431,"threshold_uncertainty_score":0.0032506585},"labels":[],"label_agreement":null},{"id":"W4410858904","doi":"10.1038/s44319-025-00478-6","title":"Author Correction: Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis","year":2025,"lang":"en","type":"erratum","venue":"EMBO Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre; Prevention of Organ Failure; Provincial Health Services Authority; University of British Columbia","funders":"","keywords":"Acetylation; Oxidative stress; Metastasis; Cancer research; Block (permutation group theory); Class (philosophy); Medicine; Biology; Internal medicine; Chemistry; Cancer; Computer science; Biochemistry; Gene; Artificial intelligence; Mathematics; Combinatorics","score_opus":0.01038350189207781,"score_gpt":0.3036276184116274,"score_spread":0.29324411651954957,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4410858904","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00037540362,0.0013835072,0.0013889624,0.03181322,0.95887834,0.000026723856,0.001077065,0.00065763574,0.0043990454],"genre_scores_gemma":[0.024314616,0.01128297,0.011045928,0.056100734,0.24749382,0.00021869989,0.0042545213,0.0025796439,0.642709],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99812514,0.00014776901,0.00018936566,0.00029003093,0.0010701085,0.0001775421],"domain_scores_gemma":[0.993127,0.0013715877,0.00044891663,0.00047301277,0.0040484383,0.0005309768],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015259942,0.002192177,0.0015532256,0.0031991256,0.0027666087,0.0023126088,0.0032597664,0.006287009,0.06248877],"category_scores_gemma":[0.012867029,0.0010291522,0.0017110622,0.0015631604,0.0016081057,0.001577688,0.0012839271,0.007974094,0.026527638],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006413767,0.000010685566,0.000049109836,0.0001332865,0.000015978989,0.0005680739,0.000016989947,0.00006815495,0.00044572877,0.00059022673,0.9911856,0.006851972],"study_design_scores_gemma":[0.00006104554,0.000027431277,0.0006143685,0.00013030812,0.00007795641,0.0011617321,0.00004656588,0.00035891254,0.0031847921,0.00083482306,0.9934597,0.000042320513],"about_ca_topic_score_codex":0.01654828,"about_ca_topic_score_gemma":0.020854618,"teacher_disagreement_score":0.06248877,"about_ca_system_score_codex":0.0030406178,"about_ca_system_score_gemma":0.0032323769,"threshold_uncertainty_score":0.20904577},"labels":[],"label_agreement":null},{"id":"W4410878021","doi":"10.1016/j.bbi.2025.05.027","title":"HDAC inhibitors engage MITF and the disease-associated microglia signature to enhance amyloid β uptake","year":2025,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University Health Network","funders":"Thompson Foundation; Chan Zuckerberg Initiative; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; National Institute of Mental Health; Henry and Marilyn Taub Foundation","keywords":"Microglia; Microphthalmia-associated transcription factor; Amyloid (mycology); Signature (topology); Amyloid β; Neuroscience; Disease; Medicine; Chemistry; Biology; Immunology; Biochemistry; Internal medicine; Pathology; Gene; Inflammation","score_opus":0.0064132926376098565,"score_gpt":0.287624405220604,"score_spread":0.28121111258299414,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4410878021","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9803949,0.008537246,0.003907179,0.00071680814,0.00027457016,0.000061213366,0.00068955607,0.0003189474,0.0050996263],"genre_scores_gemma":[0.9937463,0.0018357394,0.0009325695,0.0001503226,0.000050606664,0.000026403819,0.00032017697,0.000021666021,0.0029162508],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999895,0.000009613542,0.000004210657,0.000017654242,0.000020868623,0.000052672513],"domain_scores_gemma":[0.9999596,0.000004314664,0.0000106177,0.000004566298,0.000005806518,0.000015059167],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013116843,0.00040224835,0.00032390215,0.00015484219,0.00018747288,0.00034877894,0.00019348621,0.00030959112,0.003271704],"category_scores_gemma":[0.00010856047,0.00014760942,0.0003014136,0.00009423409,0.00020242897,0.00021731015,0.000116359115,0.0007467772,0.0006775554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008679162,0.00013576292,0.00041432036,0.00007843886,0.000036329147,0.00005193261,0.000015900845,0.0001167832,0.9908873,0.0003355835,0.0006340395,0.006425635],"study_design_scores_gemma":[0.00015267458,0.0013076909,0.011580114,0.00001862632,0.000061855295,0.00033535264,0.000065195905,0.00081740035,0.9773244,0.0002204893,0.00810437,0.000011918094],"about_ca_topic_score_codex":0.0007776871,"about_ca_topic_score_gemma":0.0034228975,"teacher_disagreement_score":0.003271704,"about_ca_system_score_codex":0.00044946943,"about_ca_system_score_gemma":0.0002282023,"threshold_uncertainty_score":0.010944903},"labels":[],"label_agreement":null},{"id":"W4412079648","doi":"10.1053/j.gastro.2025.07.003","title":"Chemical Perturbations Impacting Histone Acetylation Govern Colorectal Cancer Differentiation","year":2025,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Magyar Tudományos Akadémia; Colorectal Cancer Alliance; Massachusetts Institute of Technology; Hungarian Research Network; American Cancer Society; Dana Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Acetylation; Histone; Colorectal cancer; Cancer research; Biology; Cancer; Genetics; Gene","score_opus":0.0067567868394791146,"score_gpt":0.29813694237961724,"score_spread":0.29138015554013813,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412079648","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9917794,0.0017611522,0.001809268,0.00029018844,0.00008756578,0.000037003785,0.00040935268,0.000082623126,0.003743548],"genre_scores_gemma":[0.99603313,0.0011038267,0.00071110803,0.00007433715,0.0000072293446,0.000009320557,0.00019145994,0.000013363259,0.0018561624],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992335,0.000008705525,0.0000052503715,0.000012487941,0.000021257882,0.000029017227],"domain_scores_gemma":[0.999931,0.000012001636,0.000023042381,0.0000081333155,0.000007229658,0.000018587894],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000094326606,0.00017429437,0.00012485262,0.00014107236,0.00015841008,0.00034311923,0.00016643458,0.0002350289,0.0020901333],"category_scores_gemma":[0.0001349777,0.00019241289,0.00016826243,0.00016037568,0.0002600136,0.00018419315,0.00013902731,0.00046852743,0.0003434586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022592414,0.000022814134,0.0002677719,0.00002457139,0.0000060719763,0.000017202514,0.000006301915,0.00012359048,0.9978529,0.00026963407,0.000051192525,0.0011321476],"study_design_scores_gemma":[0.000020487923,0.00023468709,0.0028133432,0.000002768585,0.000011325236,0.00003986765,0.000026505557,0.00051752187,0.99458873,0.00006773442,0.0016734871,0.0000033554688],"about_ca_topic_score_codex":0.0012568142,"about_ca_topic_score_gemma":0.004278261,"teacher_disagreement_score":0.0020901333,"about_ca_system_score_codex":0.0005023441,"about_ca_system_score_gemma":0.00029584934,"threshold_uncertainty_score":0.0069921613},"labels":[],"label_agreement":null},{"id":"W4412505268","doi":"10.21203/rs.3.rs-6837535/v1","title":"HDAC11-Driven STAT3 Activation Modulates Epigenetic Regulation, Promoting Pro-Inflammatory Cytokine Production and Endothelial Dysfunction in Diabetes","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Medical Research Council; Lembaga Pengelola Dana Pendidikan; Queen's University Belfast; European Commission; Queen's University; British Heart Foundation","keywords":"Cytokine; Epigenetics; Endothelial dysfunction; Diabetes mellitus; Immunology; Cancer research; Cell biology; Medicine; Biology; Internal medicine; Endocrinology; Genetics; Gene","score_opus":0.02133162044246842,"score_gpt":0.322041235503669,"score_spread":0.30070961506120053,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412505268","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9744039,0.008962895,0.006370967,0.0009735543,0.0005247671,0.000033648103,0.0030810786,0.00024852486,0.0054006283],"genre_scores_gemma":[0.9881479,0.0027392104,0.0010464517,0.00016040934,0.00008324491,0.00002307379,0.0015988435,0.000057479945,0.0061434563],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998204,0.00001986065,0.0000108765125,0.00003802425,0.000036511876,0.00007441655],"domain_scores_gemma":[0.9999049,0.000012452021,0.000029319448,0.000016156013,0.000011732158,0.00002556093],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025960908,0.00033421963,0.00035995862,0.00020695082,0.00018268649,0.00062219583,0.00025181094,0.00034642976,0.006636638],"category_scores_gemma":[0.00020746846,0.00024668872,0.00046381957,0.00031467038,0.00029897687,0.00020718617,0.00027566572,0.00088430586,0.0011469394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0029934922,0.000093000286,0.0027533101,0.00017341682,0.00005845017,0.00012939781,0.00003125821,0.0002676142,0.9836776,0.0006381781,0.0009712803,0.008213044],"study_design_scores_gemma":[0.00037128804,0.00065022067,0.07222124,0.00003158744,0.00019440416,0.00059964036,0.0001443287,0.0029342382,0.91233575,0.0009195973,0.0095723625,0.000025282437],"about_ca_topic_score_codex":0.0008669912,"about_ca_topic_score_gemma":0.0015232734,"teacher_disagreement_score":0.006636638,"about_ca_system_score_codex":0.0004564338,"about_ca_system_score_gemma":0.0003251496,"threshold_uncertainty_score":0.022201777},"labels":[],"label_agreement":null},{"id":"W4412955022","doi":"10.1038/s41598-025-13845-z","title":"Abacavir enhances the efficacy of doxorubicin via inhibition of histone demethylase KDM5B in breast cancer","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"All-India Institute of Medical Sciences; Science and Engineering Research Board; Indian Council of Medical Research; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Demethylase; Cancer research; Doxorubicin; Cell cycle checkpoint; Apoptosis; Cancer cell; Cell cycle; Breast cancer; Pharmacology; Biology; Histone; Chemistry; Cancer; Chemotherapy; DNA; Biochemistry; Genetics","score_opus":0.007829947180015668,"score_gpt":0.3224391992430084,"score_spread":0.31460925206299273,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412955022","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9812439,0.012850047,0.0019536798,0.00021687412,0.000119349206,0.000059277816,0.00030878044,0.00014707303,0.0031009738],"genre_scores_gemma":[0.9938215,0.0029575555,0.0013241166,0.00007320672,0.000015527712,0.000030856223,0.00025357408,0.00001248534,0.0015111018],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999219,0.000018737263,0.0000074306768,0.000013854914,0.000019110868,0.00001906681],"domain_scores_gemma":[0.9999747,0.000004966587,0.000005353496,0.0000032481498,0.00000475759,0.0000069801713],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012849945,0.00023245288,0.00029589672,0.00022516739,0.00009257469,0.0002038761,0.00018349863,0.00018516376,0.0016535769],"category_scores_gemma":[0.00009513672,0.00009567457,0.00020338953,0.00012547694,0.00009480878,0.00016034204,0.0001117106,0.00037473167,0.00023224686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007099843,0.00020263768,0.00042103545,0.00022775345,0.00002736997,0.00006422575,0.000016962762,0.0003049274,0.9772071,0.00016900102,0.00032505667,0.02032393],"study_design_scores_gemma":[0.000099743804,0.0017246442,0.0050374363,0.000015152629,0.00006169606,0.00027408692,0.000023499533,0.0024225048,0.98155403,0.00006394864,0.008714491,0.00000889134],"about_ca_topic_score_codex":0.00041788502,"about_ca_topic_score_gemma":0.0008191886,"teacher_disagreement_score":0.0016535769,"about_ca_system_score_codex":0.0001999532,"about_ca_system_score_gemma":0.00013034776,"threshold_uncertainty_score":0.005531788},"labels":[],"label_agreement":null},{"id":"W4414323140","doi":"10.1021/acs.jmedchem.5c01932","title":"Hyperagonism of a Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Hybrid Molecule","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; French Infrastructure for Integrated Structural Biology; Agence Nationale de la Recherche; McGill University","keywords":"Calcitriol receptor; Coactivator; Histone deacetylase; Acetylation; Histone deacetylase inhibitor; Agonist; Small molecule; In vitro","score_opus":0.0059983152383553265,"score_gpt":0.28587538776761307,"score_spread":0.27987707252925775,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4414323140","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9902872,0.00164538,0.002490853,0.0001810418,0.00009389745,0.000064008695,0.0005957379,0.00014309038,0.0044988603],"genre_scores_gemma":[0.9928179,0.0005490706,0.0028021475,0.00010179331,0.000016528618,0.000046535886,0.00045219535,0.000013279611,0.0032004765],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999385,0.000008195698,0.000003552321,0.000016712143,0.000015356445,0.000017655413],"domain_scores_gemma":[0.9999708,0.000006918879,0.000005268236,0.0000033930182,0.0000023941125,0.000011232805],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000059312188,0.00018130327,0.00016236426,0.00014732173,0.00008605578,0.00017139169,0.00018028019,0.00020856784,0.0029014521],"category_scores_gemma":[0.000049567403,0.00006528876,0.00013659487,0.0001437163,0.00012898019,0.000095990305,0.0000893202,0.00043786629,0.00037571913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003733197,0.0000877349,0.00015240394,0.00002502174,0.0000073830292,0.000038995186,0.00000876912,0.000085959065,0.9957743,0.00016103957,0.00016188463,0.0031231097],"study_design_scores_gemma":[0.00006238839,0.0011300085,0.0015035674,0.0000028756162,0.000023775456,0.00019717963,0.000019684452,0.0006888358,0.9890404,0.000048469192,0.007276233,0.0000066222387],"about_ca_topic_score_codex":0.00028804375,"about_ca_topic_score_gemma":0.00052941387,"teacher_disagreement_score":0.0029014521,"about_ca_system_score_codex":0.00017425715,"about_ca_system_score_gemma":0.00009471825,"threshold_uncertainty_score":0.009706378},"labels":[],"label_agreement":null},{"id":"W4414945341","doi":"10.1093/brain/awaf380","title":"A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Petro-Canada","funders":"Eikonizo Therapeutics; Target ALS; Association for Frontotemporal Degeneration","keywords":"Proteostasis; HDAC6; Amyotrophic lateral sclerosis; Frontotemporal dementia; SOD1; Intracellular; Neurodegeneration","score_opus":0.035379904695931746,"score_gpt":0.28608160440878877,"score_spread":0.25070169971285705,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4414945341","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8978242,0.06707241,0.014350699,0.0013314518,0.00037970266,0.0005836082,0.0013102508,0.0007790216,0.016368633],"genre_scores_gemma":[0.9631155,0.016077377,0.009097191,0.000552138,0.00005621269,0.00021053794,0.0014501848,0.000022793329,0.009418108],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999336,0.0000068304307,0.0000052739715,0.000012794655,0.000020285219,0.00002131118],"domain_scores_gemma":[0.99997485,0.0000022022898,0.0000065086747,0.0000018292202,0.0000041778812,0.0000104311],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015414922,0.00056217035,0.0004414412,0.0001878155,0.00017744371,0.00023945935,0.00029981235,0.00045600696,0.0013407685],"category_scores_gemma":[0.00005829649,0.00016788326,0.00032998345,0.00013047722,0.000158495,0.00021897702,0.0001776555,0.0006063464,0.0007323491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007152813,0.0003121287,0.0005126817,0.00026427765,0.000050852002,0.00044048417,0.00004121456,0.00027382426,0.95731753,0.00050733105,0.0012654113,0.03829892],"study_design_scores_gemma":[0.0012186533,0.008352353,0.009033572,0.000054237393,0.00027941164,0.006195913,0.00004782313,0.0031912476,0.9032135,0.0003462663,0.06801504,0.000052066996],"about_ca_topic_score_codex":0.00081387174,"about_ca_topic_score_gemma":0.0034798626,"teacher_disagreement_score":0.0013407685,"about_ca_system_score_codex":0.0005286552,"about_ca_system_score_gemma":0.00034306542,"threshold_uncertainty_score":0.0044853687},"labels":[],"label_agreement":null},{"id":"W4415209048","doi":"10.14740/jocmr6370","title":"Adenosine Monophosphate-Activated Protein Kinase Activation and Mammalian Target of Rapamycin Complex 1 Inhibition: A Mechanistic Rationale for Anti-Aging Therapy in Type 2 Diabetes","year":2025,"lang":"en","type":"review","venue":"Journal of Clinical Medicine Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"","funders":"","keywords":"mTORC1; AMPK; Type 2 diabetes; Adenosine; Protein kinase A; Inflammation; Diabetes mellitus; Kinase","score_opus":0.20448122466155372,"score_gpt":0.5013505694030868,"score_spread":0.29686934474153304,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4415209048","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.027276758,0.879261,0.016110482,0.038997587,0.01024842,0.00047552245,0.00053496513,0.00037221427,0.026723104],"genre_scores_gemma":[0.1709584,0.7685758,0.019589242,0.01919564,0.0054868883,0.0008920247,0.0007327414,0.00007175626,0.014497553],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99977976,0.000068906906,0.000017568436,0.000042523912,0.000044720367,0.000046607714],"domain_scores_gemma":[0.9998609,0.000027467157,0.000028742594,0.000011104488,0.000034309953,0.000037511585],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008892344,0.0008995595,0.00094964,0.000749655,0.00042637065,0.0011218089,0.00096617744,0.0013294023,0.0030719345],"category_scores_gemma":[0.00040497843,0.00021577798,0.0009104845,0.00042530484,0.00082164025,0.0010722659,0.0007637794,0.0043831607,0.00097508647],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0044800634,0.0040900568,0.0012151061,0.008597915,0.00054510403,0.002040968,0.00030599197,0.0016514137,0.099987045,0.12084145,0.074806154,0.6814387],"study_design_scores_gemma":[0.004196579,0.007345567,0.006615308,0.0030056105,0.0008488365,0.0039546946,0.00028270177,0.0031732363,0.046026427,0.05091482,0.8734482,0.0001879269],"about_ca_topic_score_codex":0.0003821121,"about_ca_topic_score_gemma":0.0010387206,"teacher_disagreement_score":0.0030719345,"about_ca_system_score_codex":0.000575047,"about_ca_system_score_gemma":0.0010264487,"threshold_uncertainty_score":0.010276616},"labels":[],"label_agreement":null},{"id":"W4415944109","doi":"10.1007/s00213-025-06937-1","title":"Histone deacetylase inhibitor sodium butyrate increases risk-taking during acquisition of the rat gambling task","year":2025,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Institute of Neurosciences, Mental Health and Addiction","keywords":"Sodium butyrate; Histone deacetylase inhibitor; Histone deacetylase; Cued speech; HDAC1; Histone deacetylase 5; Task (project management)","score_opus":0.009878205966511974,"score_gpt":0.3326381524230065,"score_spread":0.32275994645649453,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4415944109","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99889815,0.00021154454,0.00020700213,0.00015900552,0.000044122964,0.000017959745,0.00013919112,0.00005087752,0.00027212276],"genre_scores_gemma":[0.99519736,0.00046105788,0.0005178674,0.00010602592,0.000033612912,0.0000643171,0.00043479662,0.000033554497,0.0031514696],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997123,0.000045656237,0.00002126919,0.000052728068,0.00005465259,0.00011339398],"domain_scores_gemma":[0.9990245,0.000105706946,0.00025458483,0.00010383277,0.0000446156,0.0004666959],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019592898,0.0010450552,0.0013710696,0.00027466172,0.00025716575,0.0005806468,0.00050982425,0.0008143108,0.0036046354],"category_scores_gemma":[0.0008240616,0.00058621727,0.0004132907,0.00018581975,0.00066517753,0.0005356197,0.00038699826,0.0029516334,0.00049076567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.09658336,0.008428069,0.00549033,0.00017127943,0.0002603287,0.00016686892,0.00016129576,0.00037818158,0.8732221,0.00019770834,0.0005061792,0.01443428],"study_design_scores_gemma":[0.0045216787,0.067852676,0.11737035,0.00007904804,0.0005909831,0.00032553583,0.00066588906,0.0074981106,0.798883,0.00053561345,0.0015555408,0.0001214395],"about_ca_topic_score_codex":0.0044713295,"about_ca_topic_score_gemma":0.011456009,"teacher_disagreement_score":0.0044713295,"about_ca_system_score_codex":0.00059625664,"about_ca_system_score_gemma":0.0011389913,"threshold_uncertainty_score":0.012058675},"labels":[],"label_agreement":null},{"id":"W4416827536","doi":"10.1080/15384047.2025.2589666","title":"High-throughput screening identifies the activity of histone deacetylase inhibitors in patient-derived models of soft tissue sarcoma","year":2025,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Cancer Research","funders":"Medical Research Council; Institute of Genetics; Chief Scientist Office; Department of Health and Social Care; Cancer Research UK; Wellcome Trust; National Institute for Health and Care Research; Sarcoma UK","keywords":"Histone deacetylase; Soft tissue sarcoma; Doxorubicin; Histone; Sarcoma; Histone deacetylase inhibitor; Histone deacetylase 2","score_opus":0.021213777527724614,"score_gpt":0.34510473214670045,"score_spread":0.3238909546189758,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4416827536","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9841867,0.0034836566,0.005908806,0.00017893473,0.000041479423,0.00023086173,0.0034520596,0.000288138,0.0022293883],"genre_scores_gemma":[0.98488903,0.002847868,0.0045184954,0.00009182283,0.000009712293,0.00016641228,0.0050177,0.000023423343,0.0024354958],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979657,0.000030810097,0.00001596119,0.00003712808,0.000088001296,0.000031579144],"domain_scores_gemma":[0.9999138,0.000023795712,0.000016965061,0.000010247622,0.000017779672,0.000017448108],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027748782,0.0005195987,0.0005923412,0.0005025065,0.00014806306,0.00041279595,0.00030114074,0.00031076986,0.0019584293],"category_scores_gemma":[0.00017349732,0.00020447903,0.0004524722,0.0003519167,0.00013755963,0.00012474589,0.00019696027,0.0005544207,0.00059257436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00052523025,0.00048065046,0.0018649242,0.00015651845,0.00005502673,0.00019931728,0.000024707868,0.0016615145,0.9842957,0.000115537325,0.00059178047,0.010029082],"study_design_scores_gemma":[0.00015891742,0.005367506,0.013233727,0.000022923368,0.00019576318,0.0015933566,0.00006246366,0.007439312,0.9657141,0.00013035802,0.0060578217,0.00002386178],"about_ca_topic_score_codex":0.00089935306,"about_ca_topic_score_gemma":0.0027270543,"teacher_disagreement_score":0.0019584293,"about_ca_system_score_codex":0.0003802037,"about_ca_system_score_gemma":0.00033463538,"threshold_uncertainty_score":0.0065516233},"labels":[],"label_agreement":null},{"id":"W48767408","doi":"10.4049/jimmunol.182.supp.135.36","title":"Histone deacetylase regulation of MAP kinase phosphatase-1 acetylation and inflammation (135.36)","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"HDAC1; Histone deacetylase; Acetylation; Gene silencing; Inflammation; Histone; Histone deacetylase 2; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Kinase; Cancer research; HDAC3; Biology; Cell biology; Epigenetics; Chemistry; Biochemistry; Immunology","score_opus":0.007638946937923834,"score_gpt":0.26557759930303393,"score_spread":0.2579386523651101,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W48767408","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9234622,0.04746866,0.0074243597,0.0014400488,0.0006250343,0.00016372667,0.0030086657,0.0005124127,0.015894864],"genre_scores_gemma":[0.97618514,0.009358501,0.0026948908,0.00028562374,0.00011377874,0.00008344992,0.0015921168,0.00003318674,0.009653317],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992645,0.00000895142,0.0000044564304,0.000016558184,0.000016202097,0.000027443768],"domain_scores_gemma":[0.9999654,0.000001964806,0.00001155532,0.0000021594183,0.000006054609,0.0000128292],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011762888,0.00046333126,0.00019823636,0.00021613688,0.00018709789,0.00026345023,0.0001752282,0.00016158201,0.003277866],"category_scores_gemma":[0.00007216283,0.00013590642,0.00029291198,0.00017374814,0.00015957364,0.0001222142,0.00017903463,0.0004515871,0.0007619079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00053281675,0.00008199631,0.0008647778,0.00022096123,0.000027960914,0.000106659994,0.000016566926,0.00015420844,0.98642886,0.00050964474,0.0010500189,0.010005519],"study_design_scores_gemma":[0.00024295239,0.0006827122,0.0593687,0.000032306558,0.000081628204,0.0006261903,0.000052590865,0.0015768491,0.91459215,0.00049800513,0.022228677,0.00001718892],"about_ca_topic_score_codex":0.0012963741,"about_ca_topic_score_gemma":0.0023660373,"teacher_disagreement_score":0.003277866,"about_ca_system_score_codex":0.00047555982,"about_ca_system_score_gemma":0.00040487727,"threshold_uncertainty_score":0.010965586},"labels":[],"label_agreement":null},{"id":"W571592493","doi":"10.1016/j.bbrc.2015.06.090","title":"Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice","year":2015,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Trichostatin A; Carcinogenesis; Cancer research; Histone deacetylase; Genetically modified mouse; Histone deacetylase inhibitor; Transgene; Chemistry; Biology; Molecular biology; Cancer; Histone; Biochemistry; Gene","score_opus":0.10251968959037008,"score_gpt":0.39103415420875376,"score_spread":0.2885144646183837,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W571592493","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99273163,0.0006473446,0.002268535,0.00038900453,0.0000967444,0.00005981181,0.0013607602,0.0005877502,0.0018584263],"genre_scores_gemma":[0.98724085,0.000984142,0.0020509986,0.0001428401,0.000037767193,0.00008364184,0.0012257537,0.00019263609,0.008041253],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995503,0.00007047686,0.000041688352,0.00008231175,0.00012400205,0.00013116979],"domain_scores_gemma":[0.9992324,0.00011923394,0.00025974776,0.00008309705,0.000032153413,0.00027335482],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028676385,0.0009229506,0.0005663518,0.0016527522,0.00035380456,0.000556355,0.0006170953,0.0007510519,0.003178284],"category_scores_gemma":[0.00023326192,0.00052572513,0.0007517106,0.00056408136,0.00082174403,0.00038649776,0.0003609837,0.0019536018,0.00096986606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029007206,0.00008463697,0.00016005526,0.00001239939,0.000007387855,0.00010142924,0.000012920738,0.000049047416,0.9986665,0.000088690496,0.00006280731,0.00046394224],"study_design_scores_gemma":[0.00007244181,0.00052205264,0.0027468961,0.0000054507764,0.000028635137,0.00035551682,0.000062380896,0.0006561443,0.994107,0.000059044818,0.0013774154,0.0000069656544],"about_ca_topic_score_codex":0.0020441243,"about_ca_topic_score_gemma":0.003711782,"teacher_disagreement_score":0.003178284,"about_ca_system_score_codex":0.0006326573,"about_ca_system_score_gemma":0.0005398958,"threshold_uncertainty_score":0.010632455},"labels":[],"label_agreement":null},{"id":"W644277546","doi":"10.1200/jco.2009.27.15_suppl.e22017","title":"Investigation of HDAC inhibition targeting of BRCA1 expression as a mechanism to enhance platinum sensitivity in breast and ovarian cancer","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Cisplatin; Carboplatin; Ovarian cancer; Cancer research; Breast cancer; Flow cytometry; MTT assay; Histone deacetylase inhibitor; Medicine; Cell culture; Cancer; Molecular biology; Histone deacetylase; Biology; Internal medicine; Immunology; Chemotherapy; Histone; DNA; Biochemistry","score_opus":0.03583562840852877,"score_gpt":0.417113696360159,"score_spread":0.3812780679516302,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W644277546","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.989416,0.0067477673,0.0011014787,0.00015840083,0.00006166408,0.000095699215,0.00047069418,0.00006127781,0.0018870856],"genre_scores_gemma":[0.99178725,0.0037934445,0.0014213572,0.00007835422,0.000015930413,0.00007258346,0.0007051363,0.000015566015,0.0021102414],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999285,0.000009957008,0.000007709281,0.000013029954,0.000019267054,0.000021528007],"domain_scores_gemma":[0.9999573,0.000008133536,0.000010442802,0.0000051287648,0.000007999569,0.000010946153],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015658753,0.0001907475,0.000384339,0.00018448826,0.0000983704,0.00025675245,0.0002330845,0.00019020791,0.001465634],"category_scores_gemma":[0.00008165664,0.00010676054,0.0002676244,0.00021614757,0.00012834345,0.00011044423,0.000097239295,0.00037593645,0.00036311694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005951943,0.0002716372,0.0013860427,0.0001915573,0.000027989754,0.00006949228,0.000018545532,0.00015214174,0.98819435,0.00012711713,0.00023926675,0.008726727],"study_design_scores_gemma":[0.0001684539,0.0034386313,0.011612671,0.000012924773,0.00009664447,0.00045068908,0.00005076387,0.0013296623,0.97425437,0.00004590251,0.0085330885,0.0000062276704],"about_ca_topic_score_codex":0.0004985777,"about_ca_topic_score_gemma":0.00091539003,"teacher_disagreement_score":0.001465634,"about_ca_system_score_codex":0.00028632293,"about_ca_system_score_gemma":0.00026197717,"threshold_uncertainty_score":0.004903078},"labels":[],"label_agreement":null},{"id":"W653311130","doi":"10.1200/jco.2006.24.18_suppl.6500","title":"Clinical activity and safety of the histone deacetylase inhibitor MGCD0103: Results of a phase I study in patients with leukemia or myelodysplastic syndromes (MDS)","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nausea; Internal medicine; Pharmacokinetics; Anorexia; Oncology; Myelodysplastic syndromes; Pharmacodynamics; Leukemia; Vomiting; Mucositis; Gastroenterology; Adverse effect; Pharmacology; Phases of clinical research; Toxicity; Bone marrow","score_opus":0.043873317621000135,"score_gpt":0.42761684070166034,"score_spread":0.3837435230806602,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W653311130","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9962369,0.0017219429,0.00040863839,0.00016591289,0.000021321717,0.00044572545,0.0004073122,0.000049080772,0.0005429185],"genre_scores_gemma":[0.99299675,0.0016401884,0.0015278355,0.000523697,0.000082853156,0.00049163005,0.0018912654,0.00002307341,0.00082271884],"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","domain_scores_codex":[0.9996871,0.0001462255,0.000021611088,0.000048350736,0.000039826315,0.00005695354],"domain_scores_gemma":[0.9993297,0.00015410638,0.00013673825,0.000053966058,0.000035677276,0.00028990666],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013608056,0.0009549505,0.001436328,0.00025758415,0.000282136,0.0006194462,0.00060668803,0.0007946009,0.0017082456],"category_scores_gemma":[0.0008786882,0.00035386393,0.000791911,0.00038910983,0.0008437181,0.00046261481,0.0002479725,0.001925961,0.00047566678],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.39647928,0.091515735,0.045788106,0.0011994927,0.0018326291,0.00084244873,0.0009004654,0.0049939104,0.20622016,0.00027890914,0.005634566,0.24431433],"study_design_scores_gemma":[0.23736574,0.6631059,0.07421763,0.000059269754,0.0009736567,0.0010120306,0.00008617014,0.002100636,0.015429396,0.00018192828,0.005416245,0.000051403087],"about_ca_topic_score_codex":0.0007780441,"about_ca_topic_score_gemma":0.0015349129,"teacher_disagreement_score":0.0017082456,"about_ca_system_score_codex":0.0006737329,"about_ca_system_score_gemma":0.0009814397,"threshold_uncertainty_score":0.0071967244},"labels":[],"label_agreement":null},{"id":"W6901532533","doi":"10.60692/c8zqb-nr667","title":"Characterization and subcellular localization of histone deacetylases and their roles in response to abiotic stresses in soybean","year":2018,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Subcellular localization; Histone; Epigenetics; Arabidopsis; Gene; Abiotic component; Abiotic stress; Gene expression; Function (biology)","score_opus":0.012863234231473614,"score_gpt":0.23993594721199693,"score_spread":0.2270727129805233,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6901532533","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9960641,0.0012405998,0.0011229367,0.000029407054,0.000005436294,0.000012130967,0.0010376567,0.0000170437,0.00047069823],"genre_scores_gemma":[0.9911547,0.00080347894,0.00321252,0.000066122535,0.0000060778016,0.000029031458,0.0033099316,0.000018270492,0.0013998816],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999466,0.0000028333175,0.0000071175336,0.000022247568,0.000010980498,0.000010153073],"domain_scores_gemma":[0.99991834,0.000008833959,0.000024261195,0.0000071156837,0.000014351612,0.000027034825],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000090108544,0.00022138916,0.000298065,0.0003177662,0.00015224077,0.00019820705,0.00013312162,0.0001742417,0.00031834506],"category_scores_gemma":[0.00008602165,0.00016539505,0.0003809591,0.00029025687,0.00012958844,0.00016724273,0.00017731315,0.00023407956,0.00021715151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006534532,0.0000039444885,0.002037091,0.00003210337,0.000004693368,0.000044330623,0.000025613617,0.000035321485,0.9970817,0.000018146673,0.0000074908166,0.0006442325],"study_design_scores_gemma":[0.000053510186,0.00041622916,0.4763589,0.000021498394,0.00012231315,0.0011856152,0.00036295704,0.002183659,0.51328015,0.00019502836,0.005785293,0.00003486656],"about_ca_topic_score_codex":0.0019202809,"about_ca_topic_score_gemma":0.0025164569,"teacher_disagreement_score":0.0019202809,"about_ca_system_score_codex":0.0002534143,"about_ca_system_score_gemma":0.00018300816,"threshold_uncertainty_score":0.003818214},"labels":[],"label_agreement":null},{"id":"W6901933906","doi":"10.6084/m9.figshare.15020789","title":"Additional file 1 of Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Panobinostat; Histone deacetylase inhibitor; Histone deacetylase; Sarcoma; Epithelioid sarcoma; Immunohistochemistry; Receptor","score_opus":0.014827888781370402,"score_gpt":0.26863656034434785,"score_spread":0.25380867156297743,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6901933906","genre_codex":"dataset","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00036843363,0.00006811701,0.0005988078,0.00013422625,0.000052071013,0.00013568847,0.9968489,0.00059051334,0.0012032441],"genre_scores_gemma":[0.009326486,0.00037878432,0.0052525895,0.00047051001,0.00009897637,0.0024638344,0.96959877,0.000825387,0.011584722],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9993585,0.00006226995,0.00010777563,0.0001402534,0.00021968539,0.000111470734],"domain_scores_gemma":[0.9917372,0.005141324,0.00068949524,0.00058167113,0.0014067633,0.00044359884],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0014446871,0.0010621273,0.001915953,0.0016169222,0.0009883012,0.0015898364,0.0018430225,0.0013044477,0.8917987],"category_scores_gemma":[0.0148853855,0.0007055639,0.0009590499,0.0030683738,0.0002734624,0.0013936171,0.0007329747,0.0010432608,0.20536774],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001734211,0.00043214904,0.001890365,0.007271092,0.00009916765,0.00020126093,0.000084807056,0.0005951748,0.0021007613,0.0008846315,0.96440357,0.020302707],"study_design_scores_gemma":[0.011807862,0.0017721727,0.030504396,0.0049679326,0.0003636108,0.0012323756,0.00040090043,0.002746218,0.01030803,0.007900686,0.92772466,0.00027107052],"about_ca_topic_score_codex":0.0035971918,"about_ca_topic_score_gemma":0.0073150042,"teacher_disagreement_score":0.8917987,"about_ca_system_score_codex":0.0011227203,"about_ca_system_score_gemma":0.002205368,"threshold_uncertainty_score":0.15433604},"labels":[],"label_agreement":null},{"id":"W6902091081","doi":"10.6084/m9.figshare.13685003.v1","title":"Additional file 1 of Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Mechanism (biology); Inhibitory postsynaptic potential; Fluoxetine; Depression (economics); Mechanism of action; Order (exchange)","score_opus":0.02432989490987215,"score_gpt":0.2611312524567321,"score_spread":0.23680135754685994,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6902091081","genre_codex":"dataset","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0003205057,0.000048080652,0.00039141366,0.00013749802,0.00004250948,0.000112395704,0.9976787,0.0004135688,0.00085532124],"genre_scores_gemma":[0.013847763,0.0005021707,0.006018519,0.0009668743,0.00016063117,0.0033593965,0.95882887,0.0011510461,0.015164698],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9994473,0.000074131356,0.000093756404,0.00012923277,0.00016545667,0.00009006702],"domain_scores_gemma":[0.9884192,0.008431484,0.000776821,0.0006331944,0.0012490414,0.0004903224],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0012490132,0.00089071254,0.0015401162,0.0017125233,0.0008599071,0.0014342723,0.0016619144,0.0012781516,0.87565184],"category_scores_gemma":[0.014024644,0.00066288695,0.0010612594,0.0026169354,0.000296238,0.0013703286,0.0007274522,0.0010523455,0.15825358],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001490394,0.00029874415,0.0022545697,0.0055570197,0.00010278698,0.00018661107,0.00009040554,0.0005811866,0.00114034,0.0010100165,0.96826965,0.019018378],"study_design_scores_gemma":[0.015956398,0.0018513214,0.049749486,0.007264014,0.0006553828,0.0016317144,0.0005955832,0.0032249382,0.0071484135,0.017674448,0.89387953,0.00036886436],"about_ca_topic_score_codex":0.0043931394,"about_ca_topic_score_gemma":0.008080835,"teacher_disagreement_score":0.87565184,"about_ca_system_score_codex":0.0008606407,"about_ca_system_score_gemma":0.0016417423,"threshold_uncertainty_score":0.17736751},"labels":[],"label_agreement":null},{"id":"W6902195842","doi":"10.6084/m9.figshare.26584899.v1","title":"Additional file 1 of MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology","funders":"","keywords":"Platinum; Dual (grammatical number); Cell; Cell culture; Cytotoxicity","score_opus":0.019349484278078255,"score_gpt":0.2625126683426718,"score_spread":0.24316318406459353,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6902195842","genre_codex":"dataset","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00014244096,0.00002555448,0.0003096479,0.00007292941,0.000027175818,0.000066001696,0.997881,0.000518017,0.00095725455],"genre_scores_gemma":[0.0037438602,0.00016423386,0.0025031534,0.00034079346,0.000053667867,0.0010623767,0.9850965,0.00089220895,0.0061431956],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9994424,0.000061621366,0.00007525789,0.0001374376,0.00019015015,0.0000931158],"domain_scores_gemma":[0.99367887,0.0039083986,0.0004269809,0.0006007865,0.001024317,0.0003605926],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0011554296,0.0012186174,0.0017233882,0.0018250576,0.00096682383,0.0017101999,0.0021545927,0.001468238,0.8765603],"category_scores_gemma":[0.00872549,0.00087605184,0.000962882,0.002994709,0.0002255634,0.0014361521,0.0008206923,0.0013786508,0.24743171],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00049890106,0.00020107228,0.00095593475,0.00279307,0.000052219744,0.0000895137,0.000030418607,0.00039590552,0.0011400046,0.00064431183,0.9834759,0.009722673],"study_design_scores_gemma":[0.006107659,0.0007405556,0.01999899,0.0022089274,0.00025375112,0.0007176308,0.0002087879,0.0022321888,0.007651871,0.007289955,0.952413,0.00017673812],"about_ca_topic_score_codex":0.0045648674,"about_ca_topic_score_gemma":0.009052158,"teacher_disagreement_score":0.8765603,"about_ca_system_score_codex":0.0011997238,"about_ca_system_score_gemma":0.0018715836,"threshold_uncertainty_score":0.17607182},"labels":[],"label_agreement":null},{"id":"W6902380237","doi":"10.6084/m9.figshare.26584899","title":"Additional file 1 of MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat","year":2024,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology","funders":"","keywords":"Platinum; Dual (grammatical number); Cell; Cell culture; Cytotoxicity","score_opus":0.019349484278078255,"score_gpt":0.2625126683426718,"score_spread":0.24316318406459353,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6902380237","genre_codex":"dataset","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00014244096,0.00002555448,0.0003096479,0.00007292941,0.000027175818,0.000066001696,0.997881,0.000518017,0.00095725455],"genre_scores_gemma":[0.0037438602,0.00016423386,0.0025031534,0.00034079346,0.000053667867,0.0010623767,0.9850965,0.00089220895,0.0061431956],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9994424,0.000061621366,0.00007525789,0.0001374376,0.00019015015,0.0000931158],"domain_scores_gemma":[0.99367887,0.0039083986,0.0004269809,0.0006007865,0.001024317,0.0003605926],"candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0011554296,0.0012186174,0.0017233882,0.0018250576,0.00096682383,0.0017101999,0.0021545927,0.001468238,0.8765603],"category_scores_gemma":[0.00872549,0.00087605184,0.000962882,0.002994709,0.0002255634,0.0014361521,0.0008206923,0.0013786508,0.24743171],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00049890106,0.00020107228,0.00095593475,0.00279307,0.000052219744,0.0000895137,0.000030418607,0.00039590552,0.0011400046,0.00064431183,0.9834759,0.009722673],"study_design_scores_gemma":[0.006107659,0.0007405556,0.01999899,0.0022089274,0.00025375112,0.0007176308,0.0002087879,0.0022321888,0.007651871,0.007289955,0.952413,0.00017673812],"about_ca_topic_score_codex":0.0045648674,"about_ca_topic_score_gemma":0.009052158,"teacher_disagreement_score":0.12343973,"about_ca_system_score_codex":0.0011997238,"about_ca_system_score_gemma":0.0018715836,"threshold_uncertainty_score":0.17607182},"labels":[],"label_agreement":null},{"id":"W6920640227","doi":"10.6084/m9.figshare.13685003","title":"Additional file 1 of Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Mechanism (biology); Inhibitory postsynaptic potential; Fluoxetine; Depression (economics); Mechanism of action; Order (exchange)","score_opus":0.02432989490987215,"score_gpt":0.2611312524567321,"score_spread":0.23680135754685994,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6920640227","genre_codex":"dataset","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0003205057,0.000048080652,0.00039141366,0.00013749802,0.00004250948,0.000112395704,0.9976787,0.0004135688,0.00085532124],"genre_scores_gemma":[0.013847763,0.0005021707,0.006018519,0.0009668743,0.00016063117,0.0033593965,0.95882887,0.0011510461,0.015164698],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9994473,0.000074131356,0.000093756404,0.00012923277,0.00016545667,0.00009006702],"domain_scores_gemma":[0.9884192,0.008431484,0.000776821,0.0006331944,0.0012490414,0.0004903224],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0012490132,0.00089071254,0.0015401162,0.0017125233,0.0008599071,0.0014342723,0.0016619144,0.0012781516,0.87565184],"category_scores_gemma":[0.014024644,0.00066288695,0.0010612594,0.0026169354,0.000296238,0.0013703286,0.0007274522,0.0010523455,0.15825358],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001490394,0.00029874415,0.0022545697,0.0055570197,0.00010278698,0.00018661107,0.00009040554,0.0005811866,0.00114034,0.0010100165,0.96826965,0.019018378],"study_design_scores_gemma":[0.015956398,0.0018513214,0.049749486,0.007264014,0.0006553828,0.0016317144,0.0005955832,0.0032249382,0.0071484135,0.017674448,0.89387953,0.00036886436],"about_ca_topic_score_codex":0.0043931394,"about_ca_topic_score_gemma":0.008080835,"teacher_disagreement_score":0.87565184,"about_ca_system_score_codex":0.0008606407,"about_ca_system_score_gemma":0.0016417423,"threshold_uncertainty_score":0.17736751},"labels":[],"label_agreement":null},{"id":"W6930119626","doi":"10.5281/zenodo.10085483","title":"Fig. 4. Ptomaphagus parashant. A in Ptomaphagus Parashant Peck And Wynne, New Species (Coleoptera: Leiodidae: Cholevinae: Ptomaphagini): The Most Troglomorphic Cholevine Beetle Known From Western North America","year":2013,"lang":"en","type":"other","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University","funders":"","keywords":"Holotype; Paratype; Allotype; Dorsum; Peck (Imperial)","score_opus":0.01712969003642686,"score_gpt":0.23486402616278904,"score_spread":0.21773433612636217,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6930119626","genre_codex":"empirical","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.66013235,0.002961902,0.011569544,0.0012421019,0.00080255227,0.0004909765,0.015865112,0.0014197706,0.30551568],"genre_scores_gemma":[0.89031136,0.0012608316,0.010358986,0.0003062753,0.0000663265,0.00014254797,0.010335944,0.0001475451,0.087070175],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9999764,0.0000015461147,0.0000011555925,0.00001026785,0.000006468198,0.0000041163175],"domain_scores_gemma":[0.9999782,0.0000023508885,0.0000068748227,0.0000023206253,0.00000319651,0.000007065723],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000020451014,0.00029973633,0.000104113904,0.000733741,0.00055702304,0.00022130136,0.00018097459,0.00029922754,0.018520935],"category_scores_gemma":[0.00004333375,0.00013648407,0.0001923124,0.00042438388,0.00029511182,0.00021523303,0.00033529993,0.00056443986,0.0044063507],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010649891,0.00016215938,0.041786894,0.00084571063,0.000070391114,0.0044868602,0.0010204983,0.0007867861,0.5937015,0.0051415106,0.04430973,0.30662292],"study_design_scores_gemma":[0.00008448669,0.0003316604,0.576737,0.00016606355,0.00012581387,0.014801878,0.0017535116,0.001207603,0.046992503,0.0012204119,0.35653907,0.00003992369],"about_ca_topic_score_codex":0.0064181085,"about_ca_topic_score_gemma":0.013859288,"teacher_disagreement_score":0.98147905,"about_ca_system_score_codex":0.00025848456,"about_ca_system_score_gemma":0.00017559984,"threshold_uncertainty_score":0.06195867},"labels":[],"label_agreement":null},{"id":"W6930172012","doi":"10.5281/zenodo.12146391","title":"Zahlenfuchs 1 pdf download","year":2024,"lang":"de","type":"other","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Context (archaeology); Gloom; Staring; Subpoena; Pretext","score_opus":0.017190976655803582,"score_gpt":0.25173310789312314,"score_spread":0.23454213123731957,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6930172012","genre_codex":"other","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":"other","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0014101698,0.004828153,0.008572715,0.001494168,0.0034955868,0.00073929306,0.033305045,0.018905735,0.92724913],"genre_scores_gemma":[0.0034417042,0.0030218388,0.0029216497,0.0005676156,0.00037534855,0.00032811635,0.02276515,0.0050780172,0.9615006],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99881184,0.000072273644,0.000066823006,0.00020061503,0.0007017723,0.00014674386],"domain_scores_gemma":[0.99828017,0.00026888447,0.00006032626,0.000326139,0.00073538494,0.00032913894],"candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0010442476,0.0019179299,0.0017925866,0.004264517,0.0016459721,0.004322223,0.0018668764,0.0019926983,0.85346705],"category_scores_gemma":[0.0040206886,0.0013402572,0.001265267,0.0031037766,0.0006674407,0.0050764713,0.004108423,0.0030268263,0.80899984],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014200597,0.00009134304,0.000098194076,0.0006894428,0.000011588603,0.00014223462,0.000064981105,0.00017691629,0.0051135314,0.003675903,0.8663458,0.123448096],"study_design_scores_gemma":[0.000019845926,0.0000343307,0.00018237601,0.0000833504,0.00000516751,0.000089915775,0.000023475335,0.00006107084,0.0019956534,0.000757187,0.99673516,0.000012401946],"about_ca_topic_score_codex":0.0020297505,"about_ca_topic_score_gemma":0.0037333588,"teacher_disagreement_score":0.14653295,"about_ca_system_score_codex":0.0014949357,"about_ca_system_score_gemma":0.0016596888,"threshold_uncertainty_score":0.2090115},"labels":[],"label_agreement":null},{"id":"W6930373293","doi":"10.5281/zenodo.12320992","title":"soins de plaie pdf","year":2024,"lang":"fr","type":"other","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Medical care; Medical practice; Primary health care","score_opus":0.01834004056099734,"score_gpt":0.2569263519056495,"score_spread":0.23858631134465216,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6930373293","genre_codex":"other","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":"other","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0013072905,0.003240706,0.0015619212,0.0031178764,0.0053789676,0.00048112686,0.013043776,0.004284352,0.9675839],"genre_scores_gemma":[0.0039438982,0.0027294133,0.0011798596,0.0015967184,0.0015057664,0.00028242733,0.00929559,0.001593492,0.97787285],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9985222,0.00015922378,0.000082979874,0.00015204631,0.00089185924,0.00019166348],"domain_scores_gemma":[0.9960756,0.00058454566,0.0002611302,0.00039252528,0.0017757649,0.00091045443],"candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0013699607,0.0012362358,0.0010311995,0.003721325,0.0018513958,0.007439132,0.0010432249,0.002030731,0.814687],"category_scores_gemma":[0.005592958,0.0005790391,0.0009972639,0.003212156,0.00054407114,0.0050118035,0.0036940216,0.0019650748,0.6364081],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007600773,0.000046394587,0.000117590345,0.0002993479,0.000004375595,0.000054312557,0.00004415037,0.000046822537,0.0005739609,0.0016547091,0.93233544,0.06474697],"study_design_scores_gemma":[0.000008457421,0.00001924703,0.00032263942,0.00007067179,0.0000018848865,0.00006306045,0.000026077789,0.000018244893,0.00015325964,0.0003169127,0.9989931,0.0000064382048],"about_ca_topic_score_codex":0.0015992663,"about_ca_topic_score_gemma":0.0033077584,"teacher_disagreement_score":0.18531299,"about_ca_system_score_codex":0.0011941805,"about_ca_system_score_gemma":0.001825943,"threshold_uncertainty_score":0.2643264},"labels":[],"label_agreement":null},{"id":"W6939245145","doi":"10.60692/5wjn3-x3w73","title":"Characterization and subcellular localization of histone deacetylases and their roles in response to abiotic stresses in soybean","year":2018,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Subcellular localization; Histone; Epigenetics; Arabidopsis; Gene; Abiotic component; Abiotic stress; Gene expression; Function (biology)","score_opus":0.012863234231473614,"score_gpt":0.23993594721199693,"score_spread":0.2270727129805233,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6939245145","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9960641,0.0012405998,0.0011229367,0.000029407054,0.000005436294,0.000012130967,0.0010376567,0.0000170437,0.00047069823],"genre_scores_gemma":[0.9911547,0.00080347894,0.00321252,0.000066122535,0.0000060778016,0.000029031458,0.0033099316,0.000018270492,0.0013998816],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999466,0.0000028333175,0.0000071175336,0.000022247568,0.000010980498,0.000010153073],"domain_scores_gemma":[0.99991834,0.000008833959,0.000024261195,0.0000071156837,0.000014351612,0.000027034825],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000090108544,0.00022138916,0.000298065,0.0003177662,0.00015224077,0.00019820705,0.00013312162,0.0001742417,0.00031834506],"category_scores_gemma":[0.00008602165,0.00016539505,0.0003809591,0.00029025687,0.00012958844,0.00016724273,0.00017731315,0.00023407956,0.00021715151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006534532,0.0000039444885,0.002037091,0.00003210337,0.000004693368,0.000044330623,0.000025613617,0.000035321485,0.9970817,0.000018146673,0.0000074908166,0.0006442325],"study_design_scores_gemma":[0.000053510186,0.00041622916,0.4763589,0.000021498394,0.00012231315,0.0011856152,0.00036295704,0.002183659,0.51328015,0.00019502836,0.005785293,0.00003486656],"about_ca_topic_score_codex":0.0019202809,"about_ca_topic_score_gemma":0.0025164569,"teacher_disagreement_score":0.0019202809,"about_ca_system_score_codex":0.0002534143,"about_ca_system_score_gemma":0.00018300816,"threshold_uncertainty_score":0.003818214},"labels":[],"label_agreement":null},{"id":"W6957935561","doi":"10.60692/t5nmc-5nq17","title":"Quantitative structure–activity relationship analysis and virtual screening studies for identifying HDAC2 inhibitors from known HDAC bioactive chemical libraries","year":2017,"lang":"en","type":"article","venue":"Greater South Information System","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University","funders":"","keywords":"Virtual screening; Histone deacetylase 2; Quantitative structure–activity relationship; Drug discovery; Histone deacetylase; Set (abstract data type); Discriminative model; Support vector machine","score_opus":0.09504135467053976,"score_gpt":0.32772268744307353,"score_spread":0.23268133277253378,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6957935561","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9090441,0.0041934405,0.08234845,0.00020385915,0.00001986666,0.00012527578,0.00105996,0.00040284026,0.002602317],"genre_scores_gemma":[0.98232526,0.000846522,0.015794817,0.000028511706,0.000008006375,0.000051004656,0.0006300541,0.000011787917,0.00030403523],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99948275,0.00024563816,0.00003175048,0.00006677829,0.00013199185,0.000041039966],"domain_scores_gemma":[0.9992124,0.00057969417,0.000091204216,0.00004578419,0.000054029493,0.000016776052],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015422162,0.0006942105,0.0009861017,0.00093497324,0.00014981527,0.00050822867,0.00043186938,0.00028679255,0.0009047639],"category_scores_gemma":[0.0017131005,0.00018460248,0.0012795761,0.0010147304,0.00028991228,0.0004779001,0.00029143813,0.00057041354,0.0001504922],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007992608,0.0007051131,0.0058244397,0.0005595537,0.0004332752,0.00010986719,0.000052460888,0.8272927,0.103920996,0.0033884991,0.00043146772,0.056482278],"study_design_scores_gemma":[0.00005093428,0.0011559316,0.0033172078,0.0000070252213,0.00014590545,0.000063116444,0.000015329284,0.95716625,0.036883578,0.0006195103,0.00055187684,0.000023317323],"about_ca_topic_score_codex":0.0011992438,"about_ca_topic_score_gemma":0.0010884191,"teacher_disagreement_score":0.0015422162,"about_ca_system_score_codex":0.00075267145,"about_ca_system_score_gemma":0.0004150041,"threshold_uncertainty_score":0.008156061},"labels":[],"label_agreement":null},{"id":"W6958300238","doi":"10.6084/m9.figshare.16599465.v1","title":"Additional file 2 of Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Ectopic expression; Breast cancer; AKT1; Colorectal cancer; Cell migration; Protein kinase B; Endogeny; Signal transduction; Messenger RNA","score_opus":0.010411981962961205,"score_gpt":0.23882282274149702,"score_spread":0.22841084077853582,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6958300238","genre_codex":"dataset","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00020470384,0.000031769545,0.00024805972,0.000117312535,0.000042224015,0.00010543624,0.99787164,0.00044612188,0.00093272154],"genre_scores_gemma":[0.007870609,0.00026608116,0.0037975628,0.0006013409,0.00010576753,0.0020757066,0.97207737,0.0013327184,0.011872851],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9993967,0.000054636377,0.000104750034,0.00015370072,0.00017884586,0.00011144035],"domain_scores_gemma":[0.99371004,0.0038631605,0.00046936062,0.00048076687,0.0011524131,0.00032434083],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0012345057,0.0012447508,0.0017558418,0.0016607986,0.0009969828,0.0020816757,0.0018092118,0.001360494,0.90892404],"category_scores_gemma":[0.0141208405,0.0007012723,0.0010504508,0.0029189484,0.00027691486,0.001664597,0.0009784922,0.0009827239,0.22328171],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00094251276,0.00017075095,0.0020313058,0.006733058,0.00006539722,0.00015686151,0.000084057814,0.00043044353,0.0008978347,0.000800313,0.975567,0.012120405],"study_design_scores_gemma":[0.007513732,0.00065207324,0.026503576,0.004212021,0.00019513119,0.0007539608,0.000442295,0.0018774472,0.0036233529,0.007637568,0.9463804,0.00020847873],"about_ca_topic_score_codex":0.005640218,"about_ca_topic_score_gemma":0.010134041,"teacher_disagreement_score":0.90892404,"about_ca_system_score_codex":0.0011918384,"about_ca_system_score_gemma":0.0018793261,"threshold_uncertainty_score":0.1299088},"labels":[],"label_agreement":null},{"id":"W6969883415","doi":"10.5285/60dd0b8f-f0c3-4e30-841b-1c2067052974","title":"A-Ci, photosynthetic capacity and dark respiration data along an elevation/temperature gradient in the Colombian Andes, 2019","year":2023,"lang":"en","type":"dataset","venue":"Open MIND","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Natural Environment Research Council","keywords":"Photosynthesis; Respiration; Photosynthetic capacity; Relative humidity; Atmosphere (unit); Respiration rate","score_opus":0.07062721163017609,"score_gpt":0.35437432467041236,"score_spread":0.28374711304023625,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6969883415","genre_codex":"dataset","genre_gemma":"dataset","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"dataset","genre_consensus":"dataset","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0005433774,0.00009660927,0.000021905764,0.000022009124,0.0000072576313,0.0000027367807,0.9989563,0.0000788374,0.00027090267],"genre_scores_gemma":[0.0011702145,0.00006470432,0.00014294486,0.000015089703,0.000003219884,0.000027550232,0.9982932,0.000023720382,0.00025941728],"study_design_codex":"not_applicable","study_design_gemma":"observational","domain_scores_codex":[0.99955124,0.000048149443,0.000045223762,0.00017445402,0.00009577422,0.00008509372],"domain_scores_gemma":[0.99912316,0.0001849508,0.00011965123,0.0001735958,0.0003036963,0.000094940115],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005095665,0.0015003071,0.001166599,0.00234649,0.00059573684,0.0014513625,0.0014224078,0.0010136149,0.019357285],"category_scores_gemma":[0.0026044447,0.0003350031,0.00084282504,0.005243426,0.0002500606,0.00060360064,0.0010269148,0.0008752813,0.02221367],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028311246,0.000067559944,0.015837392,0.0026357544,0.00022563299,0.00012245617,0.00009585937,0.0015579178,0.0007270479,0.0007423445,0.9677739,0.009930958],"study_design_scores_gemma":[0.00024248728,0.000025682164,0.069228284,0.0005867828,0.00012496956,0.00010864007,0.00023683863,0.0007915112,0.00052878616,0.000899285,0.9271642,0.0000624106],"about_ca_topic_score_codex":0.074280225,"about_ca_topic_score_gemma":0.11718929,"teacher_disagreement_score":0.074280225,"about_ca_system_score_codex":0.0012368265,"about_ca_system_score_gemma":0.0017326444,"threshold_uncertainty_score":0.14769572},"labels":[],"label_agreement":null},{"id":"W6976893083","doi":"10.6084/m9.figshare.16599465","title":"Additional file 2 of Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Ectopic expression; Breast cancer; AKT1; Colorectal cancer; Cell migration; Protein kinase B; Endogeny; Signal transduction; Messenger RNA","score_opus":0.010411981962961205,"score_gpt":0.23882282274149702,"score_spread":0.22841084077853582,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6976893083","genre_codex":"dataset","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00020470384,0.000031769545,0.00024805972,0.000117312535,0.000042224015,0.00010543624,0.99787164,0.00044612188,0.00093272154],"genre_scores_gemma":[0.007870609,0.00026608116,0.0037975628,0.0006013409,0.00010576753,0.0020757066,0.97207737,0.0013327184,0.011872851],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9993967,0.000054636377,0.000104750034,0.00015370072,0.00017884586,0.00011144035],"domain_scores_gemma":[0.99371004,0.0038631605,0.00046936062,0.00048076687,0.0011524131,0.00032434083],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0012345057,0.0012447508,0.0017558418,0.0016607986,0.0009969828,0.0020816757,0.0018092118,0.001360494,0.90892404],"category_scores_gemma":[0.0141208405,0.0007012723,0.0010504508,0.0029189484,0.00027691486,0.001664597,0.0009784922,0.0009827239,0.22328171],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00094251276,0.00017075095,0.0020313058,0.006733058,0.00006539722,0.00015686151,0.000084057814,0.00043044353,0.0008978347,0.000800313,0.975567,0.012120405],"study_design_scores_gemma":[0.007513732,0.00065207324,0.026503576,0.004212021,0.00019513119,0.0007539608,0.000442295,0.0018774472,0.0036233529,0.007637568,0.9463804,0.00020847873],"about_ca_topic_score_codex":0.005640218,"about_ca_topic_score_gemma":0.010134041,"teacher_disagreement_score":0.90892404,"about_ca_system_score_codex":0.0011918384,"about_ca_system_score_gemma":0.0018793261,"threshold_uncertainty_score":0.1299088},"labels":[],"label_agreement":null},{"id":"W6977168876","doi":"10.6084/m9.figshare.15020789.v1","title":"Additional file 1 of Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Panobinostat; Histone deacetylase inhibitor; Histone deacetylase; Sarcoma; Epithelioid sarcoma; Immunohistochemistry; Receptor","score_opus":0.014827888781370402,"score_gpt":0.26863656034434785,"score_spread":0.25380867156297743,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W6977168876","genre_codex":"dataset","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00036843363,0.00006811701,0.0005988078,0.00013422625,0.000052071013,0.00013568847,0.9968489,0.00059051334,0.0012032441],"genre_scores_gemma":[0.009326486,0.00037878432,0.0052525895,0.00047051001,0.00009897637,0.0024638344,0.96959877,0.000825387,0.011584722],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9993585,0.00006226995,0.00010777563,0.0001402534,0.00021968539,0.000111470734],"domain_scores_gemma":[0.9917372,0.005141324,0.00068949524,0.00058167113,0.0014067633,0.00044359884],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0014446871,0.0010621273,0.001915953,0.0016169222,0.0009883012,0.0015898364,0.0018430225,0.0013044477,0.8917987],"category_scores_gemma":[0.0148853855,0.0007055639,0.0009590499,0.0030683738,0.0002734624,0.0013936171,0.0007329747,0.0010432608,0.20536774],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001734211,0.00043214904,0.001890365,0.007271092,0.00009916765,0.00020126093,0.000084807056,0.0005951748,0.0021007613,0.0008846315,0.96440357,0.020302707],"study_design_scores_gemma":[0.011807862,0.0017721727,0.030504396,0.0049679326,0.0003636108,0.0012323756,0.00040090043,0.002746218,0.01030803,0.007900686,0.92772466,0.00027107052],"about_ca_topic_score_codex":0.0035971918,"about_ca_topic_score_gemma":0.0073150042,"teacher_disagreement_score":0.8917987,"about_ca_system_score_codex":0.0011227203,"about_ca_system_score_gemma":0.002205368,"threshold_uncertainty_score":0.15433604},"labels":[],"label_agreement":null},{"id":"W7000657314","doi":"","title":"Function and regulation of histone deacetylase 4","year":2006,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Library and Archives Canada","funders":"National Cancer Institute; Canadian Institutes of Health Research; McGill University","keywords":"HDAC4; HDAC10; SAP30; Histone deacetylase 5; Subcellular localization; Nuclear export signal; Histone deacetylase 2; Histone; Histone Acetyltransferases; Histone deacetylase","score_opus":0.009472364807253768,"score_gpt":0.26815647716648017,"score_spread":0.2586841123592264,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7000657314","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.80069983,0.1135529,0.021398827,0.0025362114,0.0008124054,0.00008913779,0.0018330269,0.00047668,0.058600992],"genre_scores_gemma":[0.9498756,0.01244684,0.0028758133,0.00046433546,0.00008298078,0.000028933615,0.0013052769,0.00004668925,0.032873552],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979717,0.000023547205,0.000011855972,0.00006358745,0.000050780098,0.000053195723],"domain_scores_gemma":[0.9999198,0.0000056922404,0.000019596462,0.000008614893,0.000024143654,0.000022116745],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017157971,0.00041176428,0.00022003498,0.00033812993,0.00028150188,0.0007925697,0.00048577916,0.00031639708,0.0027404597],"category_scores_gemma":[0.00013855657,0.00019555289,0.00036179728,0.00024334164,0.00032483664,0.0002525385,0.00028759096,0.0004343095,0.0012899578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044101448,0.00004753724,0.004464906,0.00016418085,0.00003985997,0.00021047992,0.00005676872,0.0005067767,0.95678777,0.005279481,0.0014153376,0.030585809],"study_design_scores_gemma":[0.00007925372,0.0004607057,0.06751973,0.000052972486,0.00008554363,0.00083099696,0.00018143709,0.0028178561,0.8110951,0.0019323892,0.11490241,0.00004149397],"about_ca_topic_score_codex":0.0044569257,"about_ca_topic_score_gemma":0.003348265,"teacher_disagreement_score":0.0044569257,"about_ca_system_score_codex":0.0015561492,"about_ca_system_score_gemma":0.00048076033,"threshold_uncertainty_score":0.011290669},"labels":[],"label_agreement":null},{"id":"W7000902522","doi":"","title":"Histone deacetylase inhibitors induce reactive oxygen species and DNA damage, and display enhanced activity in DNA repair deficient acute myeloid leukemia expressing leukemia associated fusion proteins","year":2014,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"McGill University","keywords":"DNA damage; DNA; DNA repair; Leukemia; Histone; Chromatin; Myeloid leukemia; Histone deacetylase","score_opus":0.01061406958434747,"score_gpt":0.2590196376797578,"score_spread":0.2484055680954103,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7000902522","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99594575,0.0011094317,0.0014716827,0.00005792503,0.00001555897,0.00002674035,0.00022999593,0.0000661447,0.0010767846],"genre_scores_gemma":[0.9942151,0.0011152272,0.0019073074,0.00003165672,0.000006706667,0.00002756005,0.00062661484,0.000009105465,0.0020607135],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993014,0.000008302023,0.000007816491,0.000010602191,0.000027147738,0.00001587984],"domain_scores_gemma":[0.9999678,0.000005813109,0.00001153412,0.000003581701,0.0000037047441,0.000007535762],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008736035,0.00019551412,0.00018458294,0.00018582791,0.000072903335,0.00018685844,0.00010997468,0.0001273278,0.0008411378],"category_scores_gemma":[0.000061444414,0.00008015149,0.00015653364,0.00017205582,0.000083371844,0.00010138292,0.00006802471,0.00028360338,0.00016498094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007308095,0.000041480227,0.00016300881,0.000017384655,0.0000042107713,0.000016633972,0.0000051928046,0.00008776198,0.9977749,0.00005202354,0.00003825629,0.001726161],"study_design_scores_gemma":[0.000015803935,0.00054522074,0.0024237856,0.0000014311684,0.000009247614,0.00008653291,0.000006402367,0.0004969165,0.9953062,0.000019761854,0.0010873806,0.0000012237066],"about_ca_topic_score_codex":0.000368732,"about_ca_topic_score_gemma":0.00079369236,"teacher_disagreement_score":0.0008411378,"about_ca_system_score_codex":0.00017219565,"about_ca_system_score_gemma":0.000107509775,"threshold_uncertainty_score":0.0028138757},"labels":[],"label_agreement":null},{"id":"W7018182200","doi":"","title":"Convergiendo en la epigenética. Ensayo clínico aleatorizado de Vorinostat en Deterioro Cognitivo Leve tipo Amnésico y Enfermedad de Alzheimer temprana","year":2018,"lang":"es","type":"dissertation","venue":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Vorinostat; Cognitive decline; Cognitive impairment; Alzheimer's disease","score_opus":0.012346969572214202,"score_gpt":0.2923421529077917,"score_spread":0.2799951833355775,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7018182200","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7233705,0.18238081,0.021455502,0.006787716,0.0016431395,0.00037171005,0.0057517714,0.0012702212,0.05696853],"genre_scores_gemma":[0.9196086,0.043259148,0.004786703,0.0017466028,0.00023406578,0.00024475902,0.001859813,0.00007194146,0.028188478],"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","domain_scores_codex":[0.9997844,0.000046033223,0.00001943686,0.000072051116,0.00004781164,0.000030334406],"domain_scores_gemma":[0.9997937,0.00003481576,0.000075883996,0.000020275109,0.000052219257,0.00002309615],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003055216,0.00028799378,0.00033958122,0.0003874017,0.00024692898,0.0007689059,0.00022000517,0.00048235705,0.0064710975],"category_scores_gemma":[0.00044613652,0.00023230733,0.0005955231,0.00029626538,0.00042225543,0.0004969465,0.00033957895,0.0005679343,0.00079792325],"study_design_candidate":"randomized_trial","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021475751,0.00035212823,0.016368048,0.002715539,0.00053735735,0.0010121446,0.00072208315,0.0011227657,0.74961466,0.0070923734,0.0053338236,0.21298143],"study_design_scores_gemma":[0.00036752323,0.0037546833,0.15696752,0.00066513976,0.0011028136,0.0033514262,0.0009880896,0.0034266585,0.5387597,0.00909303,0.28139946,0.00012405097],"about_ca_topic_score_codex":0.0020366062,"about_ca_topic_score_gemma":0.0036476294,"teacher_disagreement_score":0.0064710975,"about_ca_system_score_codex":0.0006496081,"about_ca_system_score_gemma":0.00055468635,"threshold_uncertainty_score":0.02164799},"labels":[],"label_agreement":null},{"id":"W7019896073","doi":"","title":"Induction of the antigen presentation machinery using novel small molecules","year":2017,"lang":"en","type":"other","venue":"cIRcle (University of British Columbia)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Genome British Columbia; McMaster University; University of Victoria","keywords":"Immune system; Histone deacetylase; Antigen presentation; Antigen; Major histocompatibility complex; Phenotype; Immunotherapy; Small molecule","score_opus":0.017866024541788494,"score_gpt":0.22564852694213577,"score_spread":0.2077825024003473,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7019896073","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9257536,0.019890059,0.0337901,0.00090255373,0.0004042557,0.00052713574,0.0010542548,0.00046008488,0.017218044],"genre_scores_gemma":[0.9688139,0.00872654,0.012378442,0.00027619893,0.00007288564,0.00026602048,0.0005099017,0.000033529555,0.00892265],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992836,0.0000088263005,0.0000054981942,0.000017892982,0.00002086494,0.000018542873],"domain_scores_gemma":[0.9999473,0.000011815984,0.000015317526,0.000006287595,0.000006231327,0.000013080426],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011290327,0.0003251158,0.00019004602,0.00015405795,0.00007825835,0.00030750816,0.00021697188,0.0002459759,0.001174208],"category_scores_gemma":[0.00011469503,0.00010295986,0.0002971021,0.00014203989,0.00017532613,0.00022884441,0.00015983083,0.00060401356,0.0005851996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006443483,0.00002883098,0.000048919454,0.0000750198,0.0000044372905,0.000060171726,0.000007375709,0.00010305853,0.9950471,0.00026926928,0.00007259121,0.004218786],"study_design_scores_gemma":[0.00003060825,0.0005750451,0.00043476868,0.000006295574,0.00001172753,0.00012381999,0.000008238586,0.00031766246,0.98880833,0.00006761135,0.009610304,0.000005565105],"about_ca_topic_score_codex":0.00019393965,"about_ca_topic_score_gemma":0.00039454232,"teacher_disagreement_score":0.001174208,"about_ca_system_score_codex":0.00031199623,"about_ca_system_score_gemma":0.00015091237,"threshold_uncertainty_score":0.003928125},"labels":[],"label_agreement":null},{"id":"W7030179290","doi":"","title":"Molecular architecture of a dual lysine acetyltransferase complex","year":2010,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Dual (grammatical number); Lysine; Acetyltransferase; Work (physics); Peptide sequence","score_opus":0.0111081419689614,"score_gpt":0.2632210610882414,"score_spread":0.25211291911928,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7030179290","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.940039,0.0045807892,0.027646653,0.0040825964,0.000899403,0.00010835176,0.00075394724,0.0014983733,0.020390911],"genre_scores_gemma":[0.96818507,0.0014842974,0.011571158,0.00082448265,0.00010936051,0.000042931326,0.0013633063,0.000089694244,0.01632956],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998242,0.000015442978,0.000011072231,0.00007363682,0.000040427603,0.000035174526],"domain_scores_gemma":[0.9998294,0.00001630639,0.00002227984,0.00001720548,0.000016214928,0.00009858295],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019472491,0.00056662725,0.00045572995,0.00030505736,0.00089920784,0.0014154884,0.001134122,0.00086414086,0.004477999],"category_scores_gemma":[0.0002750438,0.00059737975,0.00048458984,0.00027704344,0.00031953456,0.0009673425,0.0006636407,0.0016815437,0.0020648374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005251524,0.0002698485,0.0012524838,0.00023878952,0.000100676094,0.000986741,0.0002519086,0.0027190698,0.9643868,0.015945848,0.003729363,0.009593227],"study_design_scores_gemma":[0.00022502847,0.0009484837,0.012271875,0.00007026087,0.0001798798,0.0025912167,0.0005085187,0.06472634,0.8387013,0.0118228905,0.06774685,0.00020734983],"about_ca_topic_score_codex":0.001172273,"about_ca_topic_score_gemma":0.0010657513,"teacher_disagreement_score":0.004477999,"about_ca_system_score_codex":0.0012645532,"about_ca_system_score_gemma":0.00035733887,"threshold_uncertainty_score":0.014980435},"labels":[],"label_agreement":null},{"id":"W7067894969","doi":"","title":"Modulating chromatin remodeling as a strategy to reverse immune evasion in ovarian cancer","year":2025,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Chromatin remodeling; Immune system; Ovarian cancer; Evasion (ethics); Chromatin; Cancer; Immunity","score_opus":0.019410431348412555,"score_gpt":0.30521822247079017,"score_spread":0.28580779112237764,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7067894969","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.81670165,0.09519543,0.01276465,0.011704825,0.0021838106,0.00039248168,0.00084061536,0.001058161,0.059158385],"genre_scores_gemma":[0.8810669,0.039791353,0.0063611376,0.001541036,0.00038201088,0.00015480259,0.00043416806,0.00008741285,0.07018124],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994016,0.000005744097,0.0000018379768,0.000013520744,0.000019449346,0.000019373689],"domain_scores_gemma":[0.9999583,0.000007480442,0.000009587305,0.00000265756,0.0000074886934,0.000014554987],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021541494,0.0001884579,0.0001563269,0.0001597819,0.00023377602,0.0004709402,0.00022743944,0.00023327993,0.005883754],"category_scores_gemma":[0.00013545618,0.000111632646,0.00016062727,0.00011778929,0.00013246166,0.00015995462,0.00020758955,0.0006101697,0.00087745703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00075707916,0.00027781486,0.00112338,0.00024224649,0.000025033874,0.00007663844,0.00010539345,0.00047994388,0.7719565,0.002172451,0.008886211,0.21389736],"study_design_scores_gemma":[0.00042376903,0.0025368107,0.020124579,0.000085882,0.00014883438,0.00048137136,0.00028346357,0.0022112061,0.7672892,0.0012971549,0.20509008,0.000027654192],"about_ca_topic_score_codex":0.0008279422,"about_ca_topic_score_gemma":0.0018907062,"teacher_disagreement_score":0.005883754,"about_ca_system_score_codex":0.00021987245,"about_ca_system_score_gemma":0.00024431993,"threshold_uncertainty_score":0.019683123},"labels":[],"label_agreement":null},{"id":"W7096891476","doi":"","title":"ORIGINAL REPORT Safety of valproic acid in patients with chronic obstructive pulmonary disease: a population-based cohort study","year":2016,"lang":"en","type":"article","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Valproic Acid; COPD; Hazard ratio; Exacerbation; Retrospective cohort study; Cohort study; Adverse effect; Anticonvulsant","score_opus":0.0047694477025101425,"score_gpt":0.25294092149901737,"score_spread":0.24817147379650722,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7096891476","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9929073,0.0007177941,0.00013501475,0.00016676978,0.00003249359,0.00006935113,0.0049505904,0.000007303605,0.0010132912],"genre_scores_gemma":[0.9968298,0.00030843684,0.00008641185,0.00011960632,0.00006600886,0.000049328482,0.0021932796,0.000004177885,0.0003430966],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9986759,0.00019228108,0.00022338459,0.00037360552,0.0003850886,0.00014978093],"domain_scores_gemma":[0.9949563,0.00046877738,0.0026806553,0.00059203093,0.00080572115,0.000496479],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010506324,0.00032960236,0.0004868885,0.00075824506,0.00064333633,0.0009179281,0.00049762835,0.0005807871,0.0025522693],"category_scores_gemma":[0.0051127346,0.00032746908,0.0009406937,0.0018286296,0.00030177645,0.0005676383,0.00036552432,0.00066113676,0.00038847455],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016707405,0.00002234194,0.9986987,0.00001741481,0.00014613304,0.0000486337,0.000028227645,0.000012686097,0.000079794445,0.000007514995,0.0001920899,0.0005793727],"study_design_scores_gemma":[0.00003479579,0.00010624021,0.99917454,0.000009029986,0.000058250258,0.00016545554,0.000040337967,0.00005174866,0.000018081886,0.00000944134,0.00032834357,0.0000035738733],"about_ca_topic_score_codex":0.030939225,"about_ca_topic_score_gemma":0.022214571,"teacher_disagreement_score":0.030939225,"about_ca_system_score_codex":0.00088987564,"about_ca_system_score_gemma":0.0011743635,"threshold_uncertainty_score":0.061518252},"labels":[],"label_agreement":null},{"id":"W7100529150","doi":"","title":"RESEARCH The histone deacetylase H","year":2016,"lang":"en","type":"article","venue":"","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Histone; Acetylation; Histone deacetylase; Intestinal epithelium; Inflammation; HDAC11; Histone deacetylase 2; Gene expression; Histone deacetylase 5","score_opus":0.0379382503852539,"score_gpt":0.39038367239063043,"score_spread":0.35244542200537654,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7100529150","genre_codex":"review","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.12005636,0.5697457,0.013503866,0.02515379,0.01969581,0.00044148145,0.00709641,0.0013693915,0.24293725],"genre_scores_gemma":[0.5316953,0.1450321,0.0056300047,0.006365452,0.0053908844,0.00014934433,0.008994123,0.00011337185,0.29662946],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9997397,0.000024282504,0.000012066931,0.00011172317,0.00006751183,0.000044795193],"domain_scores_gemma":[0.9997087,0.000020410173,0.00005482194,0.00003434604,0.0000580883,0.00012359997],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046505744,0.00072437176,0.00047507614,0.00034420416,0.00045837797,0.0009355004,0.00065912725,0.00097085757,0.031202456],"category_scores_gemma":[0.00035357525,0.00019991775,0.00041720323,0.00037705372,0.00056469487,0.0004543029,0.0006003973,0.0011976297,0.016360965],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0020689513,0.00033774908,0.0054156715,0.0026342436,0.00044341848,0.0005324501,0.00015883961,0.00040203944,0.2923341,0.014496696,0.09042061,0.5907552],"study_design_scores_gemma":[0.00042964672,0.0010989708,0.02342597,0.00034233864,0.00022931259,0.0010940131,0.0001942796,0.0005466231,0.11462999,0.0033199845,0.8546515,0.000037464502],"about_ca_topic_score_codex":0.0023132148,"about_ca_topic_score_gemma":0.0029175265,"teacher_disagreement_score":0.031202456,"about_ca_system_score_codex":0.0010254635,"about_ca_system_score_gemma":0.0008184361,"threshold_uncertainty_score":0.104382634},"labels":[],"label_agreement":null},{"id":"W7132881131","doi":"","title":"Hijacking Cancer Signaling: First-in-class JPRK-targeting Ligands for Fibrolamellar Hepatocellular Carcinoma","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Allosteric regulation; In silico; Fusion protein; Ligand (biochemistry); Kinase; Cancer; Hepatocellular carcinoma; Mutant; Mutation; Drug discovery","score_opus":0.020163995443942345,"score_gpt":0.3348611347303812,"score_spread":0.31469713928643883,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7132881131","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9650113,0.010811576,0.008351396,0.001042122,0.00013255308,0.00054955843,0.0009521521,0.00050119124,0.012648268],"genre_scores_gemma":[0.9753313,0.008109569,0.005536007,0.00051149697,0.000030797877,0.00015400202,0.0012821942,0.000057753234,0.008986855],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999912,0.000013569812,0.000004984981,0.000013352834,0.000020730087,0.000035309975],"domain_scores_gemma":[0.99993587,0.000009066182,0.000012122593,0.00000768208,0.000012110668,0.000023077768],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017802481,0.0004741923,0.0005113873,0.00035906732,0.00021757327,0.00059826835,0.00037317415,0.00038918736,0.0016101144],"category_scores_gemma":[0.00016628327,0.00021170241,0.00032549634,0.0002127944,0.00026255555,0.0003549319,0.00036395338,0.0009503564,0.0009310445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00079776766,0.0009994627,0.0010346546,0.00041440112,0.00007257539,0.0010179029,0.0001901935,0.005162445,0.9259883,0.0014280765,0.0019272001,0.06096702],"study_design_scores_gemma":[0.00093328254,0.012740971,0.0047245743,0.00010303556,0.00017437326,0.0040612873,0.00019491314,0.0076492317,0.9192053,0.00077107805,0.049327735,0.00011416445],"about_ca_topic_score_codex":0.0006405034,"about_ca_topic_score_gemma":0.002318586,"teacher_disagreement_score":0.0016101144,"about_ca_system_score_codex":0.00061047275,"about_ca_system_score_gemma":0.00033207642,"threshold_uncertainty_score":0.005386293},"labels":[],"label_agreement":null},{"id":"W7132968933","doi":"","title":"Identification of Druggable Targets for MEF2D Fusion Proteins in Acute Lymphoblastic Leukemia (ALL)","year":2025,"lang":"","type":"dissertation","venue":"TSpace","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Druggability; Fusion protein; Fusion gene; Leukemia; Transcription factor; Lymphoblastic Leukemia; Identification (biology); Transcription (linguistics)","score_opus":0.011015646688452627,"score_gpt":0.3324082670592706,"score_spread":0.321392620370818,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7132968933","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97242796,0.013262611,0.0069555426,0.00038787167,0.000037326536,0.00014427993,0.0022874863,0.00021858583,0.004278256],"genre_scores_gemma":[0.95957243,0.0146669,0.0148234805,0.00016015116,0.000018074175,0.00013929866,0.004187288,0.00004751246,0.006384748],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999324,0.000007234386,0.000004708187,0.000016203676,0.000024755487,0.000014763214],"domain_scores_gemma":[0.9999738,0.00000646939,0.0000068907884,0.0000023296534,0.000004491248,0.000005930557],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019285371,0.000284442,0.00029130562,0.0003522354,0.00016696834,0.00032181156,0.00011032623,0.00020286099,0.0012626942],"category_scores_gemma":[0.000122821,0.00013006406,0.00033073805,0.000333869,0.00009305041,0.00013183516,0.0001881541,0.00027593286,0.00054428744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009666387,0.000026046619,0.0009581582,0.00008188624,0.00001174694,0.000045647936,0.0000118877,0.00025666796,0.9872602,0.000104351544,0.00021351413,0.01093318],"study_design_scores_gemma":[0.00004820295,0.00037717016,0.015673008,0.000016540935,0.00006404162,0.00041836555,0.000034360666,0.0012613045,0.97096133,0.00011139558,0.01102728,0.000007069678],"about_ca_topic_score_codex":0.00032371472,"about_ca_topic_score_gemma":0.00085434486,"teacher_disagreement_score":0.0012626942,"about_ca_system_score_codex":0.0003718026,"about_ca_system_score_gemma":0.00019789378,"threshold_uncertainty_score":0.0042241216},"labels":[],"label_agreement":null},{"id":"W7133028834","doi":"","title":"Biophysical Techniques and Assay Design for the Development of Small Molecule Inhibitors","year":2021,"lang":"","type":"dissertation","venue":"TSpace","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Small molecule; Isothermal titration calorimetry; Drug discovery; Protein–protein interaction; Ligand binding assay; Fluorescence anisotropy; Mechanism of action; Plasma protein binding; In vitro; Drug development","score_opus":0.029571936095664147,"score_gpt":0.3413566998231942,"score_spread":0.31178476372753006,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7133028834","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.02972696,0.028383017,0.9124562,0.0026338159,0.0008653246,0.0034014538,0.0021039112,0.002195369,0.018233921],"genre_scores_gemma":[0.07938024,0.046655912,0.8436118,0.0012449706,0.00037209736,0.0059806537,0.0032710733,0.00034516404,0.019138118],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99606824,0.001152993,0.00033460188,0.00048770718,0.0017327069,0.00022373434],"domain_scores_gemma":[0.99831957,0.0004985194,0.00026089887,0.00022456252,0.0005900145,0.000106455154],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004817316,0.0012653827,0.0013771298,0.0018554863,0.0006144251,0.002009418,0.0012791905,0.0014142784,0.0025809165],"category_scores_gemma":[0.003679047,0.0016314874,0.0011846732,0.0013898953,0.0008501735,0.0016590063,0.0007538954,0.0036442063,0.0044505196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001556339,0.00029643526,0.0005647542,0.0013877711,0.00005839896,0.00013325676,0.00010530967,0.0050123977,0.8884608,0.012715898,0.0038853115,0.087224066],"study_design_scores_gemma":[0.00006804609,0.00095795584,0.00087510457,0.00023706695,0.00006834036,0.00050948,0.00009528425,0.011647753,0.8275521,0.003417597,0.15446942,0.00010188017],"about_ca_topic_score_codex":0.00051348907,"about_ca_topic_score_gemma":0.00089448737,"teacher_disagreement_score":0.004817316,"about_ca_system_score_codex":0.0015345103,"about_ca_system_score_gemma":0.0016716016,"threshold_uncertainty_score":0.025476754},"labels":[],"label_agreement":null},{"id":"W7297784","doi":"10.1007/978-3-642-21631-2_10","title":"Structural Biology of Human Metal-Dependent Histone Deacetylases","year":2011,"lang":"en","type":"review","venue":"Handbook of experimental pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust; Genome Canada","keywords":"Histone; Acetylation; Epigenetics; Enzyme; Biochemistry; Chemistry; Structural biology; Biology; Peptide; HDAC10; Computational biology; Cell biology; Gene; Histone deacetylase","score_opus":0.07372291059086872,"score_gpt":0.4397562022969524,"score_spread":0.3660332917060837,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7297784","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00048003637,0.993666,0.001973949,0.00044603567,0.00051505544,0.000010569323,0.000051261657,0.000049666116,0.0028073858],"genre_scores_gemma":[0.0027646655,0.9913276,0.001528086,0.000288203,0.00031377992,0.000015269832,0.00013922401,0.000006337924,0.0036168846],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998894,0.000011992189,0.000009900999,0.000023217353,0.0000500928,0.00001543755],"domain_scores_gemma":[0.999928,0.000022499522,0.0000116597375,0.0000064395053,0.000021659878,0.000009738806],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038141513,0.0010123198,0.0010643272,0.00085570576,0.0002362509,0.0006166847,0.0012777183,0.0007048905,0.002037716],"category_scores_gemma":[0.00024174462,0.0005040195,0.00034219865,0.0014587124,0.0007990573,0.0009685046,0.00050520175,0.0017624561,0.0029395672],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015952472,0.00013204571,0.00009083041,0.009254669,0.00007096373,0.0001546662,0.00007800206,0.0017936198,0.047843296,0.026232287,0.060667362,0.8535227],"study_design_scores_gemma":[0.000022019542,0.00006239271,0.00028221591,0.00034857026,0.000028188682,0.00048225565,0.000016691782,0.0002057824,0.008433576,0.0055589476,0.98454267,0.00001671281],"about_ca_topic_score_codex":0.0010173261,"about_ca_topic_score_gemma":0.0017734363,"teacher_disagreement_score":0.002037716,"about_ca_system_score_codex":0.0012903025,"about_ca_system_score_gemma":0.000885431,"threshold_uncertainty_score":0.009361863},"labels":[],"label_agreement":null},{"id":"W815164501","doi":"10.1139/o08-097","title":"Untargeted tail acetylation of histones in chromatin: lessons from yeastThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.","year":2009,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":true,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Acetylation; Chromatin; Histone; Histone-modifying enzymes; Biology; Lysine; Epigenetics; Histone Acetyltransferases; DNA; Cell biology; Computational biology; Genetics; Chromatin remodeling; Biochemistry; Amino acid; Gene","score_opus":0.01901532040166704,"score_gpt":0.2999926982224277,"score_spread":0.28097737782076065,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W815164501","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00020050012,0.99820065,0.00030361325,0.0002962708,0.00025340248,0.000002411931,0.000012626134,0.000008804967,0.00072166824],"genre_scores_gemma":[0.0007722368,0.99796546,0.0003051942,0.00018561204,0.00011073755,0.000003082177,0.000019657962,0.0000023007563,0.000635717],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99986637,0.0000146436705,0.000017942673,0.000031109194,0.000056115816,0.000013767506],"domain_scores_gemma":[0.9997683,0.0000905607,0.000025938627,0.000014861261,0.00006945616,0.000030846124],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007235838,0.00074075686,0.0011412367,0.0012014254,0.00029165714,0.0008605947,0.0008687339,0.0010022402,0.0012908488],"category_scores_gemma":[0.00058401056,0.00031135677,0.000308351,0.0017267705,0.00072891853,0.0015477218,0.0006105336,0.0014517177,0.0018176439],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000113204216,0.000049465307,0.00017109538,0.009000629,0.00006668573,0.00037784324,0.000098472534,0.0007353974,0.009405675,0.009273132,0.024667552,0.94604087],"study_design_scores_gemma":[0.000022431868,0.00008005208,0.0005613978,0.00094421156,0.0000530842,0.0009932712,0.0000523477,0.00009178366,0.0026612906,0.0033820143,0.9911385,0.000019697185],"about_ca_topic_score_codex":0.001511081,"about_ca_topic_score_gemma":0.002683722,"teacher_disagreement_score":0.001511081,"about_ca_system_score_codex":0.00086276315,"about_ca_system_score_gemma":0.00078154553,"threshold_uncertainty_score":0.006259799},"labels":[],"label_agreement":null}]}