{"meta":{"query_hash":"ed313e58e88a","filters":{"venue":"Antibodies"},"cohort_total":14,"direct_labels_cover":0,"predictions_cover":14,"exported":14,"export_cap":100000,"truncated":false,"label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"permalink":"https://metacan.xera.ac/q/ed313e58e88a","api":"https://metacan.xera.ac/api/v1/cohort?venue=Antibodies"},"results":[{"id":"W1981214889","doi":"10.3390/antib2020193","title":"In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) Fragments","year":2013,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"","keywords":"In vivo; Single-chain variable fragment; Computational biology; Monoclonal antibody; Antibody; Function (biology); Biology; Chemistry; Cell biology; Immunology; Genetics","score_opus":0.016858200710161978,"score_gpt":0.29309245986187277,"score_spread":0.2762342591517108,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1981214889","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7293058,0.10996268,0.119344436,0.0010691002,0.0005792175,0.00047827483,0.0011239743,0.0010682156,0.03706824],"genre_scores_gemma":[0.9205124,0.037660208,0.028451625,0.00037070896,0.00015034036,0.000172915,0.0008617096,0.00009590132,0.011724153],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998486,0.0000448008,0.000008843559,0.000029220493,0.000043824846,0.000024615627],"domain_scores_gemma":[0.99992335,0.000024705923,0.000018295317,0.0000092853215,0.000013206358,0.000011129558],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033270323,0.00048108166,0.0002937479,0.00031309394,0.0001066174,0.00030677812,0.00022061373,0.00044652814,0.001838842],"category_scores_gemma":[0.00018555205,0.00012092561,0.00025651316,0.00015335491,0.00013230905,0.00019984914,0.00012521722,0.00054952345,0.00041714532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024866645,0.00013231147,0.000238756,0.00026321283,0.000016360898,0.00014295697,0.000028565364,0.000245274,0.9680494,0.00037396513,0.00057179923,0.02968872],"study_design_scores_gemma":[0.000044677563,0.0015271903,0.001974972,0.000045635457,0.00006648626,0.001283612,0.00002779066,0.0010337005,0.9704485,0.00017711824,0.02336403,0.0000062824597],"about_ca_topic_score_codex":0.0004922262,"about_ca_topic_score_gemma":0.0004954049,"teacher_disagreement_score":0.001838842,"about_ca_system_score_codex":0.0002372097,"about_ca_system_score_gemma":0.00014178753,"threshold_uncertainty_score":0.0061514974},"labels":[],"label_agreement":null},{"id":"W2081902566","doi":"10.3390/antib3020205","title":"Engineered Bovine Antibodies in the Development of Novel Therapeutics, Immunomodulators and Vaccines","year":2014,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph; Canadian Food Inspection Agency; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Antibody; Biology; Immunoglobulin light chain; Gene; Genetics; Computational biology","score_opus":0.03762164436213006,"score_gpt":0.31407926344770837,"score_spread":0.2764576190855783,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081902566","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6961817,0.107857585,0.1582125,0.0014814464,0.00082064274,0.00041972508,0.0010528438,0.0006225623,0.033351075],"genre_scores_gemma":[0.9197213,0.015157977,0.05478972,0.00044593896,0.00010713661,0.00012139831,0.00060987315,0.000048405247,0.008998342],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997812,0.00006827485,0.000012571752,0.000027888009,0.00007631515,0.000033875982],"domain_scores_gemma":[0.99991095,0.000018820225,0.00002646868,0.000008242422,0.000017078566,0.000018509689],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00050429726,0.00028652992,0.00020468736,0.00030424815,0.00009680852,0.0003468207,0.0002655344,0.0004969614,0.0010696205],"category_scores_gemma":[0.0002512033,0.00014494985,0.00015476528,0.00024181424,0.00017916833,0.00023792955,0.00023835938,0.000549772,0.00048097596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019676228,0.00013352624,0.00043823637,0.00028051433,0.00001939612,0.00012357111,0.00003001072,0.0011595039,0.9653899,0.0029980552,0.0005904028,0.028640047],"study_design_scores_gemma":[0.00011138547,0.002277009,0.0018952847,0.00009775419,0.00007902843,0.0008824238,0.000026765956,0.003519772,0.8771862,0.0009955649,0.112910636,0.000018189596],"about_ca_topic_score_codex":0.0005158608,"about_ca_topic_score_gemma":0.00077208335,"teacher_disagreement_score":0.0010696205,"about_ca_system_score_codex":0.0004396413,"about_ca_system_score_gemma":0.00021160614,"threshold_uncertainty_score":0.0035783052},"labels":[],"label_agreement":null},{"id":"W2615906896","doi":"10.3390/antib6020007","title":"Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function","year":2017,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"National Research Council Canada; Zymeworks (Canada)","funders":"Centers for Disease Control and Prevention","keywords":"Effector; Fragment crystallizable region; Antibody-dependent cell-mediated cytotoxicity; Protein engineering; Antibody; Epitope; Context (archaeology); Function (biology); Biology; Biophysics; Chemistry; Cell biology; Monoclonal antibody; Biochemistry; Genetics; Enzyme","score_opus":0.03435150278124715,"score_gpt":0.3166015176457345,"score_spread":0.28225001486448736,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2615906896","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9157618,0.0014002444,0.074867316,0.0001657574,0.000079325306,0.00010228518,0.00020315664,0.00026480557,0.0071552447],"genre_scores_gemma":[0.97079784,0.0007089106,0.02453811,0.00015163132,0.000015509448,0.0000730795,0.0002518365,0.00005590965,0.0034072972],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997408,0.000037712456,0.000022709939,0.000045778615,0.00010198894,0.00005094176],"domain_scores_gemma":[0.9999014,0.000013876105,0.000038376857,0.000010143816,0.000021254233,0.000014924144],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022182253,0.0004635248,0.00020429623,0.00035497418,0.00012331519,0.00035412816,0.0004171877,0.00041920927,0.0008338061],"category_scores_gemma":[0.00022588257,0.00014735179,0.00019545373,0.0002670769,0.00017505954,0.00031012643,0.00031869853,0.0006099877,0.0004353427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000043496497,0.000033481087,0.00006444109,0.000032694366,0.0000055741443,0.0000404301,0.000014530094,0.00050598534,0.99408984,0.0009514553,0.00007806308,0.004140091],"study_design_scores_gemma":[0.000009551885,0.00007597905,0.00016379703,0.0000028452973,0.000009005889,0.000109959205,0.000005243434,0.0025336642,0.99403375,0.0001057056,0.0029465575,0.0000039063675],"about_ca_topic_score_codex":0.00039265558,"about_ca_topic_score_gemma":0.00058122765,"teacher_disagreement_score":0.0008338061,"about_ca_system_score_codex":0.0005185782,"about_ca_system_score_gemma":0.00016050065,"threshold_uncertainty_score":0.0037625432},"labels":[],"label_agreement":null},{"id":"W2765263172","doi":"10.3390/antib6040016","title":"Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy","year":2017,"lang":"en","type":"review","venue":"Antibodies","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"European Regional Development Fund; Ligue Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Institute of Cancer Research; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Receptor; Cancer therapy; Cancer; Agonist; Tumor necrosis factor alpha; Cytokine; Antibody; Cancer cell; Biology; Cancer research; Computational biology; Immunology; Genetics","score_opus":0.07907894619068304,"score_gpt":0.3912741543676535,"score_spread":0.31219520817697044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2765263172","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00027211162,0.9960253,0.00035144947,0.0003640999,0.00033305428,0.000009877326,0.00002298929,0.000016112524,0.0026050478],"genre_scores_gemma":[0.0012587127,0.99611,0.00032904386,0.00023578199,0.00013049213,0.000010815923,0.000038793125,0.0000026412094,0.0018837294],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998472,0.000021258593,0.000018822111,0.00002340623,0.00007090315,0.000018426786],"domain_scores_gemma":[0.99987817,0.00003992791,0.000018650444,0.0000056857534,0.00004156235,0.00001598007],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045577314,0.0006733038,0.00070506986,0.0018236049,0.00023831576,0.0006968546,0.000689864,0.0008526695,0.0037100487],"category_scores_gemma":[0.00036833182,0.00022674633,0.00034745477,0.0012919004,0.00043229986,0.0010691764,0.0005569686,0.0018924492,0.002903605],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006466004,0.000107886786,0.00014824761,0.009025303,0.000047089205,0.00023442347,0.00005596997,0.00039401787,0.0070794825,0.009535352,0.030043153,0.9432643],"study_design_scores_gemma":[0.0000076167385,0.000037752958,0.00019141202,0.00060007785,0.000020941769,0.0005578616,0.000014008324,0.000041077135,0.000986334,0.0010790561,0.9964574,0.000006422512],"about_ca_topic_score_codex":0.0005675507,"about_ca_topic_score_gemma":0.0012558971,"teacher_disagreement_score":0.0037100487,"about_ca_system_score_codex":0.00068057707,"about_ca_system_score_gemma":0.000714463,"threshold_uncertainty_score":0.012411416},"labels":[],"label_agreement":null},{"id":"W2793145624","doi":"10.3390/antib7010009","title":"Structural Changes in Stx1 Engineering Monoclonal Antibody Improves Its Functionality as Diagnostic Tool for a Rapid Latex Agglutination Test","year":2018,"lang":"en","type":"article","venue":"Antibodies","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Escherichia coli; Monoclonal antibody; Hybridoma technology; Linker; Microbiology; Recombinant DNA; Single-chain variable fragment; Diphtheria toxin; Antigen; Bacteria; Chemistry; Antibody; Shiga toxin; Dissociation constant; Toxin; Biology; Biochemistry; Gene","score_opus":0.015298842604272266,"score_gpt":0.3045175525882544,"score_spread":0.28921870998398214,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2793145624","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98949414,0.00062631763,0.008502062,0.00011625269,0.000027141625,0.000024812269,0.000113451664,0.000058182333,0.0010375842],"genre_scores_gemma":[0.98936075,0.0004332809,0.00810914,0.00008126345,0.000010489584,0.000016576629,0.00033965692,0.000023042745,0.0016257372],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984634,0.000029776067,0.000014402115,0.00003310287,0.000044776098,0.00003153488],"domain_scores_gemma":[0.9998977,0.000016612546,0.000031667936,0.000010917,0.000027239908,0.000015780504],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018351368,0.0003228505,0.00016070296,0.00019006668,0.0000806294,0.00023312785,0.00021922559,0.00029164104,0.00082857715],"category_scores_gemma":[0.00025801847,0.00011245113,0.00017941777,0.00015268679,0.000109946996,0.00017210848,0.00016464591,0.0003845842,0.0002734577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000017876566,0.00001609828,0.00015008188,0.000012090803,0.000002173765,0.000027162647,0.000005999778,0.00005050679,0.99877757,0.000039891565,0.000013880085,0.0008867498],"study_design_scores_gemma":[0.0000049898467,0.00014340707,0.0012669084,0.0000032592873,0.000011048437,0.00014387364,0.000007858227,0.0006466959,0.9962057,0.000015901192,0.0015478014,0.0000024653098],"about_ca_topic_score_codex":0.0003493578,"about_ca_topic_score_gemma":0.0003897378,"teacher_disagreement_score":0.00082857715,"about_ca_system_score_codex":0.00017679941,"about_ca_system_score_gemma":0.000109704866,"threshold_uncertainty_score":0.0027717948},"labels":[],"label_agreement":null},{"id":"W2931416517","doi":"10.3390/antib8020027","title":"Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases","year":2019,"lang":"en","type":"review","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"","keywords":"Antibody; Medicine; Cerebrospinal fluid; Single-domain antibody; Central nervous system; Computational biology; Neuroscience; Immunology; Biology; Pathology","score_opus":0.1310407975241597,"score_gpt":0.4198972390929485,"score_spread":0.2888564415687888,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2931416517","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0002358893,0.9968485,0.0002207367,0.00019021964,0.00020398306,0.000008051384,0.000015721282,0.00000965793,0.0022671497],"genre_scores_gemma":[0.0011678877,0.997131,0.00027086402,0.00016166117,0.00013819242,0.000008424077,0.000023562838,0.0000014248477,0.0010968983],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998242,0.00002797845,0.000017466908,0.000024640627,0.0000860428,0.000019557625],"domain_scores_gemma":[0.9998419,0.00007261035,0.000022641538,0.00000487379,0.00004212617,0.000015806281],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042319336,0.0006901451,0.00074839237,0.002066301,0.00021326095,0.00071321125,0.00060154573,0.0009761401,0.0039402684],"category_scores_gemma":[0.00041694797,0.0001987887,0.00037837971,0.0015104546,0.0003900639,0.001000522,0.00043332594,0.0016339071,0.0021873084],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006652785,0.00011154182,0.00015660422,0.018290155,0.00007071076,0.00024966215,0.000078164274,0.0004491035,0.008687056,0.009948368,0.025493741,0.9363984],"study_design_scores_gemma":[0.000009014278,0.0000824763,0.00034776726,0.0012252574,0.000046542213,0.0008019212,0.0000269113,0.000068111665,0.0010723469,0.0015488764,0.9947613,0.000009441785],"about_ca_topic_score_codex":0.0006012156,"about_ca_topic_score_gemma":0.0011280801,"teacher_disagreement_score":0.0039402684,"about_ca_system_score_codex":0.0004608011,"about_ca_system_score_gemma":0.000681452,"threshold_uncertainty_score":0.013181448},"labels":[],"label_agreement":null},{"id":"W2980125027","doi":"10.3390/antib8040050","title":"NR4A Expression by Human Marginal Zone B-Cells","year":2019,"lang":"en","type":"article","venue":"Antibodies","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Expression (computer science); Marginal zone; Biology; Cell biology; Evolutionary biology; Genetics; Computer science","score_opus":0.016473522761831245,"score_gpt":0.25846053588750567,"score_spread":0.24198701312567442,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2980125027","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9936871,0.003020821,0.0016384228,0.00003743908,0.000009805598,0.000013954571,0.0007089515,0.00004285679,0.00084067363],"genre_scores_gemma":[0.9933484,0.0009474691,0.0019952503,0.00004537093,0.000009096122,0.000029306806,0.0015283357,0.000015040284,0.002081635],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998975,0.000015275204,0.0000066640646,0.00003154916,0.000026487261,0.000022526661],"domain_scores_gemma":[0.999954,0.0000071587383,0.000009902564,0.0000067759147,0.00001199182,0.000010113574],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277487,0.00012329649,0.00014991644,0.00019246391,0.00012902927,0.0002629406,0.00009455472,0.0001270371,0.001742948],"category_scores_gemma":[0.00017523806,0.00008566768,0.0001860811,0.00013431073,0.0001025362,0.000089613684,0.0001798204,0.00016421097,0.0007389752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020397689,0.0000055846485,0.0013669225,0.00003683468,0.0000054299503,0.000040364917,0.000052869622,0.000016035488,0.9963831,0.000025944997,0.00003162706,0.0018312911],"study_design_scores_gemma":[0.00003952872,0.0006407569,0.106879815,0.000031128937,0.000081232145,0.0014463246,0.0005144781,0.0010002045,0.8761623,0.00014951853,0.01303419,0.000020543072],"about_ca_topic_score_codex":0.0011011736,"about_ca_topic_score_gemma":0.0009652454,"teacher_disagreement_score":0.001742948,"about_ca_system_score_codex":0.000106851185,"about_ca_system_score_gemma":0.00010929494,"threshold_uncertainty_score":0.005830765},"labels":[],"label_agreement":null},{"id":"W3040981623","doi":"10.3390/antib9030032","title":"Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2","year":2020,"lang":"en","type":"review","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences Centre; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Internalization; Intracellular; Antibody-drug conjugate; Antibody; Drug; Cancer research; Medicine; Receptor; Monoclonal antibody; Biology; Pharmacology; Immunology; Cell biology; Internal medicine","score_opus":0.14169934982535706,"score_gpt":0.4447093743096557,"score_spread":0.3030100244842986,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3040981623","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0005698385,0.9946378,0.00056520075,0.0004893061,0.00025686962,0.000011777211,0.000031909778,0.00001662742,0.0034207222],"genre_scores_gemma":[0.0025020153,0.9948502,0.00045547966,0.00026432506,0.00007600346,0.000012223514,0.000034423945,0.000002250813,0.0018030425],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99984753,0.000031062213,0.000012205483,0.000021323005,0.00006377723,0.000024119172],"domain_scores_gemma":[0.9999039,0.00003666018,0.000014078093,0.00000435914,0.00003268713,0.000008373471],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042239876,0.00053065567,0.0007547627,0.0012462984,0.00019276307,0.0007519198,0.00052713184,0.00070987263,0.0029610195],"category_scores_gemma":[0.0003318204,0.00021923,0.0004509479,0.0009575087,0.00028004646,0.0010942947,0.00047392544,0.0013711642,0.0016702334],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007247539,0.0000804495,0.00014397105,0.021692852,0.000098351695,0.00024292557,0.00009816737,0.0006906819,0.015293125,0.018115118,0.026297674,0.9171743],"study_design_scores_gemma":[0.000009036415,0.00010831693,0.00031028513,0.0013916555,0.000049523194,0.0006566463,0.000037813916,0.0001464511,0.0028154177,0.0020795444,0.9923839,0.000011377382],"about_ca_topic_score_codex":0.000717949,"about_ca_topic_score_gemma":0.0012634426,"teacher_disagreement_score":0.0029610195,"about_ca_system_score_codex":0.0004860513,"about_ca_system_score_gemma":0.0007154271,"threshold_uncertainty_score":0.009905577},"labels":[],"label_agreement":null},{"id":"W4388747498","doi":"10.3390/antib12040075","title":"Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor","year":2023,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Medical Research Council; Diamond Light Source; Medical Research Council Canada; Wellcome Trust","keywords":"Paratope; Immunoglobulin D; Antibody; Idiotype; Molecular biology; Immunoglobulin Idiotypes; Immunoglobulin Fab Fragments; Monoclonal antibody; Isotype; Recombinant DNA; Antigen; Hybridoma technology; Epitope; Biology; Chemistry; Virology; Immunology; Complementarity determining region; Genetics; B cell; Gene","score_opus":0.047802626321804834,"score_gpt":0.37914583691274695,"score_spread":0.3313432105909421,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4388747498","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82649,0.0067159897,0.14964384,0.0009305045,0.00022964379,0.0007233747,0.0013254707,0.0016842914,0.012256807],"genre_scores_gemma":[0.83020204,0.0053344765,0.15019491,0.001049531,0.00006526516,0.00048706497,0.0025470415,0.000265949,0.009853732],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997482,0.000025437386,0.000015612655,0.00004313284,0.00011833043,0.000049254228],"domain_scores_gemma":[0.99986887,0.00002168811,0.000022385062,0.000018073082,0.0000273266,0.00004161035],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037984905,0.00046516763,0.0003492318,0.00041567843,0.0001498024,0.0004429697,0.00067047094,0.00047812954,0.001242509],"category_scores_gemma":[0.00019423537,0.00024398703,0.00043908783,0.00016130599,0.00028090697,0.00032457476,0.00065388787,0.0010817426,0.00087333395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00004788703,0.000044375316,0.00016649609,0.000055221913,0.0000131787465,0.00006862072,0.000016689091,0.00024875862,0.9922123,0.00043584305,0.00026026458,0.006430488],"study_design_scores_gemma":[0.00006669274,0.0004267633,0.001031438,0.000015413458,0.000051398525,0.00075017,0.000015775693,0.0026384697,0.9614295,0.0001852486,0.033373494,0.000015670703],"about_ca_topic_score_codex":0.0002771544,"about_ca_topic_score_gemma":0.00051703415,"teacher_disagreement_score":0.001242509,"about_ca_system_score_codex":0.0003459997,"about_ca_system_score_gemma":0.0003081641,"threshold_uncertainty_score":0.004156649},"labels":[],"label_agreement":null},{"id":"W4400644133","doi":"10.3390/antib13030056","title":"Immune-Related Adverse Events Associated with Atezolizumab: Insights from Real-World Pharmacovigilance Data","year":2024,"lang":"en","type":"article","venue":"Antibodies","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Atezolizumab; Adverse effect; Medicine; Immune system; Adverse Event Reporting System; Pharmacovigilance; Immunology; Nivolumab; Internal medicine; Oncology; Immunotherapy","score_opus":0.030119052346939075,"score_gpt":0.32354702952838066,"score_spread":0.2934279771814416,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400644133","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8657818,0.0886056,0.014359674,0.009576134,0.00012296063,0.00018050909,0.013106406,0.00017160141,0.008095456],"genre_scores_gemma":[0.9779479,0.0124888085,0.0037965921,0.0012541186,0.00014048831,0.000053114647,0.004095126,0.000018841798,0.00020512224],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.989233,0.0051304284,0.0021875238,0.0009893588,0.0022380224,0.0002216422],"domain_scores_gemma":[0.9375682,0.030318348,0.026259223,0.002193513,0.0031730784,0.00048769815],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.014968339,0.00026530997,0.0004919422,0.0026691952,0.00016397345,0.0015450198,0.0003607071,0.0004405128,0.0008658184],"category_scores_gemma":[0.030135995,0.0001322721,0.0010298446,0.0033515305,0.00032768518,0.0008607079,0.00069069385,0.00072877895,0.00011807267],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046363234,0.00006776383,0.91451585,0.0007325128,0.0013196698,0.00032249148,0.00029920854,0.0012352868,0.0004005793,0.0009217745,0.0020215278,0.07769963],"study_design_scores_gemma":[0.00009738787,0.00030913754,0.9623603,0.0010207952,0.001468007,0.0020848701,0.0005611617,0.0069236523,0.0013413941,0.0029942584,0.02077901,0.000060034985],"about_ca_topic_score_codex":0.0024815435,"about_ca_topic_score_gemma":0.00356596,"teacher_disagreement_score":0.014968339,"about_ca_system_score_codex":0.0006697873,"about_ca_system_score_gemma":0.0009377706,"threshold_uncertainty_score":0.07916105},"labels":[],"label_agreement":null},{"id":"W4400676936","doi":"10.3390/antib13030057","title":"Humanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework","year":2024,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; Canada Research Chairs; National Institutes of Health; Hospital for Sick Children; Office of Science; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Argonne National Laboratory; U.S. Department of Energy","keywords":"Paratope; Monoclonal antibody; Antibody; Antigen; Immunogenicity; Complementarity determining region; Human leukocyte antigen; Major histocompatibility complex; Computational biology; Biology; Humanized antibody; Immunology; Cell biology","score_opus":0.04654255567493678,"score_gpt":0.42540966716732165,"score_spread":0.3788671114923849,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400676936","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9731347,0.0009235511,0.02189914,0.00017332008,0.000045175788,0.000105601124,0.00015476921,0.00011973777,0.0034439964],"genre_scores_gemma":[0.97679645,0.0007108292,0.019283267,0.00015959125,0.000010704354,0.00004096786,0.00023120182,0.000025236897,0.0027416805],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999187,0.000016535854,0.0000044509466,0.000018476974,0.00002039996,0.000021502969],"domain_scores_gemma":[0.99995494,0.0000066484886,0.000016028978,0.000006050678,0.000005565546,0.000010776917],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017051683,0.00028021954,0.00011576734,0.00008531689,0.00006960821,0.0001426451,0.00018281108,0.00023306119,0.0010361198],"category_scores_gemma":[0.000082628954,0.00009574046,0.00015161566,0.000061421044,0.00018722904,0.000120827055,0.00015422155,0.0003710167,0.00023863064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000020368789,0.000017397959,0.0000817566,0.000015427677,0.0000023946811,0.000036238227,0.000007679096,0.00016932028,0.9976313,0.00018744387,0.000039975843,0.0017907543],"study_design_scores_gemma":[0.00001659319,0.00047601084,0.0010065058,0.000005701892,0.000011384762,0.00040636538,0.000011776955,0.00085314014,0.98891,0.000047821235,0.008250344,0.0000042733923],"about_ca_topic_score_codex":0.0004149167,"about_ca_topic_score_gemma":0.0006650824,"teacher_disagreement_score":0.0010361198,"about_ca_system_score_codex":0.00023462881,"about_ca_system_score_gemma":0.00022491654,"threshold_uncertainty_score":0.0034661293},"labels":[],"label_agreement":null},{"id":"W4400724181","doi":"10.3390/antib13030059","title":"Adverse Events of PD-1, PD-L1, CTLA-4, and LAG-3 Immune Checkpoint Inhibitors: An Analysis of the FDA Adverse Events Database","year":2024,"lang":"en","type":"article","venue":"Antibodies","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Adverse effect; CTLA-4; PD-L1; Immune system; Database; Medicine; Immunology; Computer science; Pharmacology; Immunotherapy; T cell","score_opus":0.014978496399803282,"score_gpt":0.2970432694413767,"score_spread":0.2820647730415734,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400724181","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6626165,0.06412346,0.010139916,0.0020369175,0.00019436653,0.002264357,0.2448176,0.000654995,0.013151932],"genre_scores_gemma":[0.8178851,0.02337462,0.01297982,0.001790071,0.00024540492,0.0019436995,0.13990735,0.000113357535,0.0017605354],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.9876066,0.002725622,0.0042448565,0.0014769448,0.0036711285,0.00027489898],"domain_scores_gemma":[0.95499825,0.016307876,0.021855883,0.0015152082,0.004735742,0.0005870343],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009476551,0.0004003921,0.0010738028,0.004459287,0.00038668903,0.0010517366,0.00047756857,0.0004276975,0.0016871257],"category_scores_gemma":[0.016330244,0.00017628194,0.0019971984,0.005402471,0.00019349193,0.0006773892,0.0007195577,0.00073433487,0.00032552832],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037761636,0.00026954373,0.77688926,0.006801141,0.003554418,0.00093445176,0.00029601654,0.0023513564,0.0018042699,0.0007351059,0.018796753,0.18379155],"study_design_scores_gemma":[0.0004173104,0.000892443,0.9370075,0.0014293332,0.0027765562,0.0036726675,0.00028938724,0.003557393,0.0025596502,0.0005151231,0.046792723,0.00008993082],"about_ca_topic_score_codex":0.0028016022,"about_ca_topic_score_gemma":0.004394604,"teacher_disagreement_score":0.009476551,"about_ca_system_score_codex":0.0010530173,"about_ca_system_score_gemma":0.0017374678,"threshold_uncertainty_score":0.050117433},"labels":[],"label_agreement":null},{"id":"W4412700485","doi":"10.3390/antib14030064","title":"Determination of the Epitopes of Alpha-Glucosidase Anti-Drug Antibodies in Pompe Disease Patient Plasma Samples","year":2025,"lang":"en","type":"article","venue":"Antibodies","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Jewish General Hospital; Fondation De Famille Alvin Segal; Genome Canada; Warren Y. Soper Charitable Trust; McGill University","keywords":"Epitope; Recombinant DNA; Enzyme replacement therapy; Glycogen storage disease type II; Antibody; Enzyme; Antigen; Drug; Virology; Biology; Chemistry; Disease; Molecular biology; Biochemistry; Pharmacology; Immunology; Medicine; Internal medicine; Gene","score_opus":0.016183620632939072,"score_gpt":0.3006729632587627,"score_spread":0.2844893426258236,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412700485","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9784837,0.0046802824,0.013183986,0.00019792902,0.00007925845,0.000095072595,0.0008572445,0.00017187402,0.0022507159],"genre_scores_gemma":[0.97789156,0.0018981096,0.016816674,0.00050643896,0.00006067976,0.00006724225,0.0011975213,0.00003534211,0.0015264371],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997379,0.000049805945,0.000026695785,0.00006631979,0.000085281776,0.00003389536],"domain_scores_gemma":[0.99982435,0.00006143873,0.00003062975,0.000011282433,0.00004673763,0.000025583793],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028525456,0.0004838011,0.00019798514,0.00084544404,0.00032132256,0.00033609892,0.00019023185,0.0004944557,0.00093910866],"category_scores_gemma":[0.00057866535,0.00011975173,0.00022220482,0.0003053344,0.00018264713,0.00014685623,0.00017833998,0.0005213204,0.00035326427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023737922,0.00007248003,0.008273936,0.00012879392,0.000055461176,0.0010214892,0.00020081221,0.00009533918,0.9784232,0.00011032297,0.00020348377,0.011177224],"study_design_scores_gemma":[0.00005936751,0.00092611066,0.14513233,0.000115770184,0.00018393503,0.019469684,0.00039624659,0.0033034363,0.81598824,0.00043266453,0.013957356,0.00003484359],"about_ca_topic_score_codex":0.0004910979,"about_ca_topic_score_gemma":0.0005751158,"teacher_disagreement_score":0.00093910866,"about_ca_system_score_codex":0.00013194884,"about_ca_system_score_gemma":0.00010904987,"threshold_uncertainty_score":0.003141582},"labels":[],"label_agreement":null},{"id":"W4414356495","doi":"10.3390/antib14030080","title":"Development of a Chicken Immunoglobulin Heavy Chain Variable Region (VH) Single-Domain Antibody (sdAb) Against Calsequestrin (CSQ) and Its Application","year":2025,"lang":"en","type":"article","venue":"Antibodies","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Aging","funders":"","keywords":"Fusion protein; Immunoglobulin light chain; Recombinant DNA; Antibody; Phage display; Protein engineering; Single-chain variable fragment; Alexa Fluor; Protein G; Protein A/G","score_opus":0.012794732614245243,"score_gpt":0.251205336855404,"score_spread":0.23841060424115879,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4414356495","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91701293,0.002016153,0.07807981,0.00025662713,0.000058591166,0.00021371937,0.00028980747,0.00015935695,0.0019129437],"genre_scores_gemma":[0.941677,0.0013136271,0.052947115,0.00019708418,0.000017392776,0.00008420561,0.0011866965,0.000025722586,0.0025511887],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997875,0.000029398681,0.000017860646,0.000055909,0.000074345866,0.000034928984],"domain_scores_gemma":[0.9998184,0.00002654692,0.000026447005,0.000016952446,0.00007569823,0.00003600138],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003221606,0.00047054893,0.00016552015,0.00031567187,0.00011693294,0.00022337974,0.00032943493,0.00044203555,0.0006318065],"category_scores_gemma":[0.00024977277,0.00016728307,0.0003101779,0.00016997172,0.00015704989,0.0001840378,0.00026393923,0.0005309261,0.00041111617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000013611414,0.000014878496,0.00025080328,0.00002698913,0.0000032743837,0.00002258239,0.000008358905,0.0000721892,0.9970912,0.000043704524,0.000027497488,0.0024248199],"study_design_scores_gemma":[0.000010628001,0.00029108647,0.002212834,0.000009097671,0.000021450896,0.000488,0.000021869057,0.002154565,0.9912442,0.000036740832,0.0035049322,0.0000044895132],"about_ca_topic_score_codex":0.000743271,"about_ca_topic_score_gemma":0.00078419613,"teacher_disagreement_score":0.000743271,"about_ca_system_score_codex":0.00032990324,"about_ca_system_score_gemma":0.00023008163,"threshold_uncertainty_score":0.0023936033},"labels":[],"label_agreement":null}]}