{"meta":{"query_hash":"8c662c211cab","filters":{"venue":"Bioorganic & Medicinal Chemistry Letters"},"cohort_total":890,"direct_labels_cover":0,"predictions_cover":890,"exported":890,"export_cap":100000,"truncated":false,"label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"permalink":"https://metacan.xera.ac/q/8c662c211cab","api":"https://metacan.xera.ac/api/v1/cohort?venue=Bioorganic+%26+Medicinal+Chemistry+Letters"},"results":[{"id":"W1164264743","doi":"10.1016/j.bmcl.2015.08.027","title":"Tris(3-hydroxypropyl)phosphine (THPP): A mild, air-stable reagent for the rapid, reductive cleavage of small-molecule disulfides","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Reactions","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Reagent; Phosphine; Tris; Aqueous solution; Molecule; Combinatorial chemistry; TCEP; Cleavage (geology); Reducing agent; Bond cleavage; Small molecule; Organic chemistry; Polymer chemistry; Catalysis","score_opus":0.030611976675164628,"score_gpt":0.23758040738020292,"score_spread":0.2069684307050383,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1164264743","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.80804724,0.008641486,0.16993286,0.0009850893,0.0003009325,0.0002616143,0.0012462545,0.0012833059,0.009301355],"genre_scores_gemma":[0.95507187,0.003933289,0.032818,0.00016998088,0.00009006668,0.0000909994,0.00088870124,0.0001287304,0.0068084267],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998123,0.000040794625,0.000017170665,0.000039394785,0.000054920773,0.000035403424],"domain_scores_gemma":[0.9999119,0.000018822107,0.000025219815,0.000012017624,0.000010633032,0.000021406431],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004899797,0.0005737033,0.00016861754,0.0003054782,0.0002479843,0.00024808387,0.00052051456,0.00030286395,0.0012429116],"category_scores_gemma":[0.00024351363,0.00027281864,0.00019323564,0.00017316364,0.00032626433,0.0005518574,0.000411164,0.0008515242,0.0006379268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019009245,0.000025405918,0.00008444034,0.00013644568,0.00000969287,0.00015546396,0.00004504301,0.00020664431,0.9903555,0.00077385566,0.0004199283,0.007597555],"study_design_scores_gemma":[0.00001788413,0.00016701245,0.00017816792,0.0000028801267,0.000008159132,0.00026182894,0.000008350534,0.00038703193,0.9958496,0.00009049464,0.0030235518,0.000005001773],"about_ca_topic_score_codex":0.00027355313,"about_ca_topic_score_gemma":0.00038137025,"teacher_disagreement_score":0.0012429116,"about_ca_system_score_codex":0.0002539895,"about_ca_system_score_gemma":0.0003895099,"threshold_uncertainty_score":0.0041579604},"labels":[],"label_agreement":null},{"id":"W1422080213","doi":"10.1016/j.bmcl.2015.08.075","title":"In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Universidad Autónoma del Estado de México; Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Iridoid; Enzyme; Chemistry; Cyclooxygenase; In vitro; Traditional medicine; Biochemistry; Pharmacology; Stereochemistry; Biology; Medicine; Glycoside","score_opus":0.01084783682668955,"score_gpt":0.22646170962457626,"score_spread":0.2156138727978867,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1422080213","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9931116,0.0034847863,0.00034588727,0.00005123843,0.000028906481,0.000016388345,0.0005376895,0.00001485718,0.002408759],"genre_scores_gemma":[0.98905855,0.0019880552,0.0007689762,0.00007199156,0.000019631327,0.000015559144,0.0018538622,0.0000108699605,0.0062125777],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999598,0.000004580863,0.0000031142156,0.000009329858,0.000010992388,0.000012160945],"domain_scores_gemma":[0.9998851,0.000029874898,0.000018295314,0.000006474334,0.000020198873,0.000040194896],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010686962,0.00040784656,0.00025888634,0.0003320533,0.00024702505,0.00022498902,0.00017164026,0.00016823837,0.0017118988],"category_scores_gemma":[0.00015421155,0.00014044583,0.00025104696,0.00023396489,0.00018724868,0.00017195921,0.00016032202,0.0005347792,0.00024026023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00066970603,0.000072085,0.0006322601,0.00017288813,0.000017342489,0.00010327108,0.00005882638,0.00011520095,0.9948709,0.00007814618,0.00005935219,0.003149976],"study_design_scores_gemma":[0.00016735554,0.003678923,0.06446287,0.00008949973,0.00030202878,0.0005494069,0.00034810987,0.00077664625,0.92158484,0.00014069211,0.00786464,0.000035121873],"about_ca_topic_score_codex":0.002481821,"about_ca_topic_score_gemma":0.0035191935,"teacher_disagreement_score":0.002481821,"about_ca_system_score_codex":0.00015849454,"about_ca_system_score_gemma":0.00024266743,"threshold_uncertainty_score":0.005726874},"labels":[],"label_agreement":null},{"id":"W15603965","doi":"10.1016/j.bmcl.2004.10.075","title":"Conflicting Canadian views on the value of community treatment orders: Implications for Australia and New Zealand","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Healthcare Decision-Making and Restraints","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"","keywords":"Viewpoints; Legislation; Psychological intervention; Imprisonment; Medicine; Value (mathematics); Legislature; Political science; Psychology; Criminology; Psychiatry; Law","score_opus":0.16434861884026258,"score_gpt":0.4305038951863684,"score_spread":0.2661552763461058,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W15603965","genre_codex":"commentary","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.15173298,0.010346138,0.00062995526,0.72149146,0.00091680104,0.00006903177,0.00070102175,0.000016797756,0.11409577],"genre_scores_gemma":[0.9161441,0.00988903,0.0017162594,0.060774826,0.00040530245,0.000034620225,0.00012656719,0.000033826796,0.010875562],"study_design_codex":"design_other","study_design_gemma":"qualitative","domain_scores_codex":[0.9907087,0.0023196503,0.00057766493,0.00056571077,0.0044573387,0.001370908],"domain_scores_gemma":[0.9544597,0.015385375,0.0044631623,0.0008736277,0.014379407,0.010438713],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01263049,0.00024545653,0.00054358103,0.0014620285,0.0058257785,0.0058192722,0.0018254346,0.0025736364,0.014083078],"category_scores_gemma":[0.066724725,0.00035117252,0.0005861153,0.0029267306,0.005499457,0.0024401974,0.0024086093,0.00542927,0.0003877708],"study_design_candidate":"qualitative","study_design_consensus":null,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015762718,0.00024569224,0.15719278,0.0011061736,0.0005478077,0.0025318705,0.04486441,0.002521145,0.0012615923,0.22273098,0.20955564,0.35586566],"study_design_scores_gemma":[0.000527224,0.00037763105,0.4114247,0.0045238025,0.000682981,0.0014613079,0.10307288,0.0035555852,0.00095714896,0.07444375,0.3981018,0.00087116915],"about_ca_topic_score_codex":0.95525587,"about_ca_topic_score_gemma":0.9805008,"teacher_disagreement_score":0.0618534,"about_ca_system_score_codex":0.0618534,"about_ca_system_score_gemma":0.121258266,"threshold_uncertainty_score":0.44877994},"labels":[],"label_agreement":null},{"id":"W17027268","doi":"10.57709/4073456","title":"Investigation Of The Rescue Of The Rubella Virus P150 Replicase Protein Q Domain By The Capsid Protein","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Virology and Viral Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institut Périmètre de physique théorique","keywords":"Capsid; Biology; RNA-dependent RNA polymerase; RNA; Phosphoprotein; Viral replication; Cell biology; Translation (biology); Protein domain; Virology; Virus; Molecular biology; Gene; Phosphorylation; Genetics; Messenger RNA","score_opus":0.010724152410937165,"score_gpt":0.2127176841835332,"score_spread":0.20199353177259605,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W17027268","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9983255,0.00030112593,0.00097186794,0.000022359976,0.0000036277158,0.00001029258,0.00006805838,0.000012742663,0.000284436],"genre_scores_gemma":[0.9958508,0.00033420773,0.002072375,0.000026619187,0.000002855554,0.000015537262,0.00033416788,0.00001592059,0.00134756],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992955,0.000012702301,0.0000061035357,0.000014463715,0.000022374894,0.000014850581],"domain_scores_gemma":[0.99992204,0.00002004537,0.000022757571,0.000011460066,0.000010928954,0.000012721639],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013111316,0.00021864884,0.00019202124,0.00007164084,0.000095018135,0.00016096981,0.00017888258,0.00024374336,0.00039080685],"category_scores_gemma":[0.00012385278,0.000082159575,0.00022372589,0.00005108943,0.00013759217,0.00015651871,0.00013603024,0.00036863497,0.00023540772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000021337679,0.0000070769056,0.00006439262,0.000014805176,0.0000011962647,0.000019053345,0.0000049229848,0.000025134737,0.9996294,0.000017738917,0.0000034568916,0.0001914428],"study_design_scores_gemma":[0.000007643221,0.00021303199,0.002653371,0.0000033594058,0.000007319453,0.00022954364,0.000021429809,0.0006436851,0.9954699,0.000018041097,0.00072946417,0.0000031849167],"about_ca_topic_score_codex":0.0006382817,"about_ca_topic_score_gemma":0.000423538,"teacher_disagreement_score":0.0006382817,"about_ca_system_score_codex":0.0002051647,"about_ca_system_score_gemma":0.0001512388,"threshold_uncertainty_score":0.0014885664},"labels":[],"label_agreement":null},{"id":"W1963976670","doi":"10.1016/j.bmcl.2008.09.004","title":"Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside–CoA bisubstrates as mechanistic probes for aminoglycoside N-6′-acetyltransferase","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University","keywords":"Aminoglycoside; Chemistry; Sulfone; Sulfonamide; Sulfoxide; Aminocyclitol; Stereochemistry; Chemical synthesis; Acetyltransferase; Tetrahedral carbonyl addition compound; Biochemistry; Antibiotics; In vitro; Organic chemistry; Acetylation","score_opus":0.039279468220463805,"score_gpt":0.2537460795991811,"score_spread":0.2144666113787173,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1963976670","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9420713,0.003761823,0.03987808,0.00050143624,0.00015481963,0.00025688988,0.0005634193,0.00041329436,0.012398761],"genre_scores_gemma":[0.97963333,0.0021780797,0.015089572,0.00008950567,0.000016833454,0.000067306915,0.00039688183,0.000046944984,0.0024814305],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998307,0.00003839061,0.000017870449,0.000028738932,0.00004524305,0.000038992017],"domain_scores_gemma":[0.99985135,0.000028525146,0.0000387151,0.0000259143,0.000023307472,0.000032069573],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004338864,0.0005436593,0.0002469523,0.00021864801,0.00029863673,0.00030840246,0.00047422506,0.00044245084,0.0008989636],"category_scores_gemma":[0.00028565136,0.0002736439,0.00025899473,0.00023599986,0.00035071635,0.00053142227,0.0002775902,0.00069068035,0.00034126887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019648238,0.00008370641,0.00014448185,0.000070551,0.000011467826,0.00019298751,0.00009956245,0.0005158537,0.98770523,0.0027209218,0.00015713509,0.008101626],"study_design_scores_gemma":[0.000017106466,0.0001854342,0.00014453258,0.0000025290917,0.0000074960603,0.0000751914,0.000010203619,0.0003843761,0.9965796,0.00014416971,0.0024430708,0.000006299813],"about_ca_topic_score_codex":0.00064147054,"about_ca_topic_score_gemma":0.0014260237,"teacher_disagreement_score":0.0008989636,"about_ca_system_score_codex":0.0005911117,"about_ca_system_score_gemma":0.0006083168,"threshold_uncertainty_score":0.004288852},"labels":[],"label_agreement":null},{"id":"W1963997070","doi":"10.1016/s0960-894x(00)00452-2","title":"Synthesis and antiviral activities of N-9-oxypurine 1,3-Dioxolane and 1,3-oxathiolane nucleosides","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Dioxolane; Chemistry; Sodium hydride; Purine; Stereochemistry; Hydride; Sugar; Combinatorial chemistry; Organic chemistry; Enzyme","score_opus":0.005507895142253967,"score_gpt":0.20398037243298744,"score_spread":0.19847247729073347,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1963997070","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9703719,0.009291666,0.0039395685,0.00019272488,0.000085050146,0.000073204064,0.00032739897,0.00006780879,0.015650725],"genre_scores_gemma":[0.98555,0.0039587854,0.003868342,0.00009126501,0.00004199758,0.000052017054,0.00034085897,0.000014006344,0.0060828864],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993527,0.000017285793,0.0000060059588,0.000009657837,0.000012154675,0.000019612471],"domain_scores_gemma":[0.9999317,0.0000151710365,0.000014631407,0.000007718743,0.00000802011,0.000022796674],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017113955,0.0002218479,0.00018277692,0.00021680437,0.00018195358,0.00024438632,0.00026222458,0.00024285282,0.0019402346],"category_scores_gemma":[0.00012652861,0.00013206388,0.0001284453,0.00011586674,0.0001857574,0.00022911424,0.00019719968,0.00026637298,0.00036970503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048031492,0.000089180234,0.00018007569,0.00019621421,0.000008173152,0.00043517625,0.000119313474,0.0005834764,0.9821989,0.0018705991,0.00017653427,0.013661979],"study_design_scores_gemma":[0.000062625084,0.0013945748,0.0008161991,0.000020283667,0.000015869718,0.00038159674,0.000031585452,0.0003616367,0.9853833,0.00023079877,0.011291872,0.000009771028],"about_ca_topic_score_codex":0.00023077104,"about_ca_topic_score_gemma":0.00042334665,"teacher_disagreement_score":0.0019402346,"about_ca_system_score_codex":0.00023489921,"about_ca_system_score_gemma":0.00021325263,"threshold_uncertainty_score":0.0064907074},"labels":[],"label_agreement":null},{"id":"W1964072554","doi":"10.1016/j.bmcl.2003.09.011","title":"Synthesis of 17β-estradiol platinum(II) complexes: biological evaluation on breast cancer cell lines","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"College of the North Atlantic; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Steroid; Estrone; Hydroxymethyl; Chemical synthesis; MCF-7; Stereochemistry; Pyridine; Estrogen; In vitro; Estrogen receptor; Biological activity; Ligand (biochemistry); Molecule; Platinum; Side chain; Cancer cell lines; Cell culture; Human breast; Breast cancer; Cancer cell; Biochemistry; Cancer; Medicinal chemistry; Internal medicine; Organic chemistry; Receptor; Hormone","score_opus":0.05841581325533945,"score_gpt":0.2771090536348045,"score_spread":0.21869324037946503,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964072554","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96844774,0.005187297,0.017459841,0.00022174793,0.00016604859,0.0004499443,0.0012003366,0.00030962756,0.006557467],"genre_scores_gemma":[0.9774228,0.0031951072,0.009437556,0.00008176436,0.00002031105,0.00022174748,0.0012189995,0.00006674781,0.008334967],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985635,0.000025292766,0.00002414088,0.000035553254,0.000036727935,0.000021902657],"domain_scores_gemma":[0.9998915,0.000024520945,0.000019471821,0.00001922708,0.000028028086,0.00001726943],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024979704,0.00026653276,0.00036589423,0.00021145004,0.00021724595,0.0002158463,0.00032109994,0.00023823397,0.0015970606],"category_scores_gemma":[0.00026872614,0.00023792162,0.00019489655,0.00023957787,0.00011273124,0.0001604595,0.00019548094,0.0002458861,0.0005079347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029083426,0.00004614336,0.00017360596,0.00012150189,0.000013699592,0.00009736062,0.00005522168,0.00022793624,0.9947102,0.00012935043,0.0001552707,0.0039788117],"study_design_scores_gemma":[0.000026648928,0.00018304879,0.0002559299,0.0000029326475,0.000016135931,0.00011865646,0.0000100024345,0.0001503543,0.9964206,0.000014324602,0.002799485,0.0000018721462],"about_ca_topic_score_codex":0.00058847945,"about_ca_topic_score_gemma":0.00083681283,"teacher_disagreement_score":0.0015970606,"about_ca_system_score_codex":0.00020897014,"about_ca_system_score_gemma":0.0001656978,"threshold_uncertainty_score":0.0053426623},"labels":[],"label_agreement":null},{"id":"W1964191731","doi":"10.1016/j.bmcl.2007.09.014","title":"ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Consiglio Nazionale delle Ricerche","keywords":"Chemistry; Vorinostat; Alkoxy group; Moiety; Ether; Enantiomer; Stereochemistry; Carbon chain; Biological activity; Hydroxamic acid; Histone deacetylase inhibitor; Structure–activity relationship; Histone deacetylase; In vitro; Alkyl; Organic chemistry; Biochemistry; Histone","score_opus":0.00809606463605626,"score_gpt":0.265959513113545,"score_spread":0.2578634484774887,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964191731","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9872012,0.005395407,0.0017090349,0.00006474635,0.000046748915,0.000046026376,0.00022096833,0.000027870177,0.005287963],"genre_scores_gemma":[0.99356866,0.0035980565,0.0012185762,0.000036771573,0.00002388711,0.000013592138,0.00018915166,0.000013522578,0.0013378495],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991906,0.00002398158,0.0000069120188,0.000011971884,0.000013641297,0.000024465115],"domain_scores_gemma":[0.9998568,0.00006551757,0.000027676928,0.000013456318,0.000016222024,0.000020365653],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024059559,0.00019993987,0.00022635925,0.00021121187,0.00009980718,0.00018282032,0.00029765608,0.00014734393,0.0019210944],"category_scores_gemma":[0.000304073,0.00013546227,0.00017423871,0.00022471955,0.00022070124,0.00037243633,0.00013491826,0.0004433089,0.00032713395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0032487256,0.0003262548,0.00065905467,0.00018021472,0.00006241932,0.00025091015,0.00009886759,0.002608472,0.9677732,0.0023103654,0.00023747294,0.02224401],"study_design_scores_gemma":[0.00036470132,0.0051016957,0.0017734293,0.000017590746,0.000111232184,0.00023923402,0.00004825372,0.003732126,0.98200005,0.0003588921,0.0062297056,0.00002317335],"about_ca_topic_score_codex":0.0004988848,"about_ca_topic_score_gemma":0.0005630304,"teacher_disagreement_score":0.0019210944,"about_ca_system_score_codex":0.00018975415,"about_ca_system_score_gemma":0.00013220211,"threshold_uncertainty_score":0.006426692},"labels":[],"label_agreement":null},{"id":"W1964256693","doi":"10.1016/j.bmcl.2012.04.128","title":"N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Cannabinoid; Cannabinoid receptor; Pyran; Carboxamide; Receptor; Pharmacology; Stereochemistry; Analgesic; Cannabinoid Receptor Agonists; Chemical synthesis; Agonist; Biochemistry; In vitro; Biology","score_opus":0.009700713539053578,"score_gpt":0.25082179306730706,"score_spread":0.24112107952825348,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964256693","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9421934,0.026639154,0.009199817,0.0005244903,0.00021793268,0.00024855987,0.0006853487,0.00053874805,0.019752579],"genre_scores_gemma":[0.9773917,0.0089476565,0.0036041916,0.00014919625,0.000051010757,0.00008807524,0.00042122827,0.000029934417,0.009316931],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989974,0.00001926595,0.00000468034,0.000015904,0.000024664494,0.000035717858],"domain_scores_gemma":[0.9999664,0.0000053184312,0.000009033196,0.000003793719,0.000005764668,0.000009762957],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016581775,0.00027778032,0.00034443656,0.00021545171,0.00022327858,0.00028264162,0.0005807146,0.00028319348,0.002223372],"category_scores_gemma":[0.00014842012,0.00014123779,0.00015659485,0.00018951962,0.00018973787,0.0002720135,0.00018434021,0.0004670368,0.0006822587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012778814,0.00033333703,0.00037830774,0.00034414593,0.0000197753,0.0005823536,0.00014307212,0.0007747421,0.9366629,0.0025580344,0.00180689,0.055118483],"study_design_scores_gemma":[0.0012438344,0.0069518997,0.008971729,0.00008279909,0.00012436399,0.0039238306,0.00011615302,0.00635693,0.90912056,0.00046431267,0.0625553,0.000088259374],"about_ca_topic_score_codex":0.0015820557,"about_ca_topic_score_gemma":0.0051002586,"teacher_disagreement_score":0.002223372,"about_ca_system_score_codex":0.00036793243,"about_ca_system_score_gemma":0.00028334014,"threshold_uncertainty_score":0.0074379444},"labels":[],"label_agreement":null},{"id":"W1964456736","doi":"10.1016/j.bmcl.2013.02.021","title":"Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Reverse transcriptase; Potency; Stereochemistry; Chemical synthesis; Reverse-transcriptase inhibitor; Nucleotide; Amine gas treating; Drug discovery; Enzyme inhibitor; Structure–activity relationship; Combinatorial chemistry; Enzyme; Biochemistry; In vitro; RNA; Organic chemistry","score_opus":0.009566750940539827,"score_gpt":0.20632578782272287,"score_spread":0.19675903688218305,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964456736","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87268937,0.07365591,0.025648179,0.0015071385,0.00047123572,0.00061273924,0.0010414962,0.0004708196,0.02390309],"genre_scores_gemma":[0.925584,0.044742823,0.014184721,0.0009300394,0.00012975823,0.00021353869,0.0011269941,0.00004504865,0.013042976],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999089,0.000015868542,0.0000050174453,0.000013619529,0.00002894023,0.000027653066],"domain_scores_gemma":[0.99993885,0.000010491901,0.0000124105345,0.000003775158,0.000012278634,0.000022169539],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021101942,0.00042167518,0.0004508084,0.00027906641,0.0002052561,0.00033423209,0.00047533592,0.0003321464,0.0016636145],"category_scores_gemma":[0.0001978268,0.00020707794,0.00023019288,0.00019543846,0.0001909921,0.00029913426,0.00027319268,0.00070627267,0.00049816846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007721284,0.0004787433,0.00067881565,0.00067390763,0.0000572001,0.0008079395,0.00017321778,0.002024199,0.89717877,0.003850384,0.0026512332,0.090653576],"study_design_scores_gemma":[0.0013139334,0.010585053,0.008599365,0.00026942207,0.00025427126,0.004705417,0.00011761013,0.009949328,0.8180889,0.0016951474,0.14430071,0.00012095204],"about_ca_topic_score_codex":0.00042003454,"about_ca_topic_score_gemma":0.0024263924,"teacher_disagreement_score":0.0016636145,"about_ca_system_score_codex":0.0003589898,"about_ca_system_score_gemma":0.00030886647,"threshold_uncertainty_score":0.005565405},"labels":[],"label_agreement":null},{"id":"W1964534766","doi":"10.1016/s0960-894x(03)00083-0","title":"Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Kinetic energy; Catalysis; Glutamic acid; Stereochemistry; Enzyme; Biochemistry; Amino acid","score_opus":0.01177334181158646,"score_gpt":0.22673543501258872,"score_spread":0.21496209320100226,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964534766","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98501104,0.002296541,0.009361142,0.00008617101,0.000045962955,0.00005870392,0.0003530335,0.0001024175,0.0026851343],"genre_scores_gemma":[0.9903785,0.0010423237,0.0058310437,0.000016355876,0.000008327244,0.000025739528,0.0003954494,0.00003812852,0.0022641348],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997782,0.000049344093,0.000026672558,0.00003698272,0.000059357706,0.000049378603],"domain_scores_gemma":[0.9997687,0.00004827377,0.000054917593,0.000028932114,0.000047212478,0.00005193244],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003281901,0.0003937182,0.000490899,0.0002160322,0.00019532799,0.00031900738,0.0005176932,0.0003597164,0.00066181883],"category_scores_gemma":[0.00040813707,0.00021134017,0.00027531036,0.000317533,0.0002522264,0.00048773832,0.00019849963,0.0005798186,0.00039711694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000449616,0.000070880276,0.00020906293,0.00009442141,0.000021525942,0.00020748863,0.00009227716,0.0007708233,0.9929113,0.0005571931,0.000075982985,0.0045393757],"study_design_scores_gemma":[0.00001384134,0.00021420568,0.0003159626,0.0000025970944,0.000009240549,0.00013503741,0.0000117818745,0.00055449747,0.997656,0.000054213007,0.0010237218,0.000008839233],"about_ca_topic_score_codex":0.0012961384,"about_ca_topic_score_gemma":0.0009271199,"teacher_disagreement_score":0.0012961384,"about_ca_system_score_codex":0.0006334194,"about_ca_system_score_gemma":0.00033868582,"threshold_uncertainty_score":0.004595816},"labels":[],"label_agreement":null},{"id":"W1964628138","doi":"10.1016/j.bmcl.2009.08.035","title":"A fluorescent substrate for carbon–phosphorus lyase: Towards the pathway for organophosphonate metabolism in bacteria","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pesticide and Herbicide Environmental Studies","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Lyase; Bacteria; Enzyme; Metabolic pathway; Biochemistry; Metabolism; Bond cleavage; Escherichia coli; Phosphorus; Substrate (aquarium); Stereochemistry; Organic chemistry; Catalysis; Biology; Gene","score_opus":0.011480860795692204,"score_gpt":0.20996621706045804,"score_spread":0.19848535626476582,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964628138","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82036644,0.004712855,0.1624903,0.0018649154,0.00012284645,0.00019661123,0.0007626346,0.00096614205,0.008517243],"genre_scores_gemma":[0.9031115,0.002856718,0.0818704,0.00020611164,0.00003237219,0.000099866884,0.0016369625,0.00016756693,0.010018569],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99975294,0.00008442118,0.000012939162,0.000046111745,0.00005796342,0.00004560696],"domain_scores_gemma":[0.9997775,0.00006674551,0.000027335152,0.000024195166,0.000042719534,0.00006156748],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043829015,0.0007104882,0.00024908618,0.00030624162,0.00031782044,0.00039358102,0.00064935186,0.0010177938,0.0011493296],"category_scores_gemma":[0.00032746376,0.00035393357,0.0002178965,0.00038643347,0.0003797113,0.0006204196,0.00045935716,0.000995357,0.0007834499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012971659,0.000030964384,0.00007277689,0.00008333392,0.0000048462366,0.0000821655,0.000026495323,0.00015734059,0.99618644,0.00045767918,0.00017958392,0.0025887066],"study_design_scores_gemma":[0.0000071936934,0.000053956766,0.00007627847,0.0000040300274,0.0000039999163,0.00008567676,0.0000061984533,0.00048272047,0.99800915,0.000039403247,0.0012282548,0.0000031794398],"about_ca_topic_score_codex":0.0011649554,"about_ca_topic_score_gemma":0.0013429277,"teacher_disagreement_score":0.0011649554,"about_ca_system_score_codex":0.0005780689,"about_ca_system_score_gemma":0.0004974007,"threshold_uncertainty_score":0.0041942596},"labels":[],"label_agreement":null},{"id":"W1964662850","doi":"10.1016/s0960-894x(01)00579-0","title":"Cryptoregiochemical analysis of an unusual bacterial desaturation","year":2001,"lang":"it","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Bacillus subtilis; Bacillales; Kinetic isotope effect; Deuterium; Bacillaceae; Bond cleavage; Stereochemistry; Delta; Cleavage (geology); Chemical synthesis; Biochemistry; Organic chemistry; Bacteria; In vitro; Catalysis","score_opus":0.009807734386101524,"score_gpt":0.244298876694401,"score_spread":0.23449114230829948,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964662850","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9925453,0.0009112846,0.003432471,0.00020299581,0.000043052045,0.000025918816,0.001020929,0.000052149848,0.0017658822],"genre_scores_gemma":[0.9953399,0.00044162685,0.0013961477,0.000053642034,0.000012014489,0.000009867471,0.0012176667,0.000011128872,0.0015180823],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990726,0.000011433086,0.0000036341912,0.000019277011,0.000018863315,0.000039648425],"domain_scores_gemma":[0.9998969,0.000015072101,0.00001781437,0.000010705163,0.000027467779,0.000032137286],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010501027,0.00042235226,0.00014542081,0.00034804587,0.00020363618,0.00024124245,0.0002250313,0.0002839911,0.0013622573],"category_scores_gemma":[0.00016820453,0.000089319095,0.00015125035,0.0003340626,0.00020850482,0.0002445679,0.00020802685,0.0004332801,0.00030881612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003960961,0.00001888604,0.00051531557,0.000016724749,0.0000063781276,0.00018080483,0.00001460103,0.000050733863,0.997031,0.00016905773,0.000030703843,0.001569654],"study_design_scores_gemma":[0.00000559199,0.00012502333,0.0034441315,0.0000021821577,0.000010004981,0.00016912642,0.000037411693,0.0003230746,0.9949621,0.000094351606,0.00082332577,0.000003736614],"about_ca_topic_score_codex":0.001772849,"about_ca_topic_score_gemma":0.0017423392,"teacher_disagreement_score":0.001772849,"about_ca_system_score_codex":0.00033370513,"about_ca_system_score_gemma":0.00026646134,"threshold_uncertainty_score":0.004557252},"labels":[],"label_agreement":null},{"id":"W1964889885","doi":"10.1016/j.bmcl.2009.07.108","title":"Direct labelling of peptides with 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG)","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Labelling; Peptide; Combinatorial chemistry; Biochemistry","score_opus":0.01243894699134126,"score_gpt":0.2587366552220114,"score_spread":0.24629770823067013,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964889885","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9310366,0.014821556,0.043395206,0.00029564978,0.00034663794,0.00021669386,0.00075539376,0.000195404,0.008937041],"genre_scores_gemma":[0.9083877,0.008243315,0.073407955,0.00026328114,0.00010867601,0.0002721442,0.0015524001,0.00017199904,0.0075924364],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978226,0.00003775101,0.000007843941,0.000073870615,0.000024142726,0.00007402152],"domain_scores_gemma":[0.99985397,0.000057343223,0.000023272283,0.000018672541,0.000015469395,0.000031208267],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036123983,0.00067804824,0.00045443722,0.00027378224,0.00032970074,0.0007217677,0.00048454988,0.00088612945,0.0014504527],"category_scores_gemma":[0.00029267583,0.00036989732,0.0003370529,0.00023337848,0.0003709373,0.000667554,0.00037839665,0.000728235,0.0007095315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003676316,0.000020171745,0.00017015958,0.00011515868,0.000013334437,0.00019587696,0.000039782597,0.000088787085,0.9949527,0.00024962678,0.00009351849,0.0036932314],"study_design_scores_gemma":[0.000057270696,0.00035870288,0.00094399194,0.000014194037,0.000036494712,0.0007902372,0.000028521274,0.0005076209,0.9890349,0.00008305909,0.008134173,0.000010781122],"about_ca_topic_score_codex":0.0009256424,"about_ca_topic_score_gemma":0.0015070009,"teacher_disagreement_score":0.0014504527,"about_ca_system_score_codex":0.00035716602,"about_ca_system_score_gemma":0.00034457303,"threshold_uncertainty_score":0.0048522353},"labels":[],"label_agreement":null},{"id":"W1965858496","doi":"10.1016/j.bmcl.2008.04.064","title":"Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Bioavailability; Quinoline; Pharmacokinetics; Small molecule; Orally active; Potency; Pharmacology; Lead compound; Stereochemistry; Oral administration; Active compound; Chemical synthesis; In vitro; Biochemistry; Organic chemistry","score_opus":0.008807688080489687,"score_gpt":0.20044589180712544,"score_spread":0.19163820372663576,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1965858496","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94033825,0.020989625,0.019071598,0.001967358,0.00035925867,0.0002241226,0.000604947,0.00028151702,0.01616335],"genre_scores_gemma":[0.97756726,0.008225133,0.0057068043,0.0003300658,0.00009910751,0.00008633106,0.0005587942,0.000020652458,0.0074058888],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999044,0.000015445217,0.000003991934,0.00001681661,0.000027843127,0.00003152802],"domain_scores_gemma":[0.9999558,0.0000069329894,0.000009572079,0.0000029775392,0.000008898348,0.000015895552],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021831012,0.00036112344,0.00030965608,0.0002187437,0.00013530464,0.00028808138,0.0003714688,0.00040473527,0.00094836287],"category_scores_gemma":[0.00015955917,0.00019930986,0.00014354456,0.000089278044,0.00015311937,0.00018837939,0.00019601568,0.0005649697,0.00039956698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037784132,0.000098083125,0.00021561923,0.00010813279,0.000019547377,0.00036802152,0.000028935197,0.00055309996,0.97615814,0.0010367327,0.00067193893,0.020363852],"study_design_scores_gemma":[0.00048705252,0.0017654027,0.0018941206,0.000020491874,0.00006970616,0.0015705599,0.000019894123,0.0031318874,0.9629815,0.00022284349,0.027818132,0.000018434464],"about_ca_topic_score_codex":0.0006838584,"about_ca_topic_score_gemma":0.0016351847,"teacher_disagreement_score":0.00094836287,"about_ca_system_score_codex":0.0004310885,"about_ca_system_score_gemma":0.00028396104,"threshold_uncertainty_score":0.003172636},"labels":[],"label_agreement":null},{"id":"W1966193246","doi":"10.1016/j.bmcl.2013.08.020","title":"Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Peptidomimetic; Amide; Stereochemistry; Azide; Peptide; Biological activity; Peptide synthesis; Enkephalin; Hydrogen bond; Triazole; δ-opioid receptor; Solid-phase synthesis; Combinatorial chemistry; Cycloaddition; Carboxamide; Alkyne; Opioid; Receptor; Catalysis; In vitro; Organic chemistry; Biochemistry; Molecule","score_opus":0.005106642376764243,"score_gpt":0.21564848781162754,"score_spread":0.2105418454348633,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966193246","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9972283,0.00050226244,0.0011301568,0.000056952336,0.000034877237,0.000039596125,0.00017018206,0.000042668795,0.00079505844],"genre_scores_gemma":[0.9969971,0.00045599657,0.0016098091,0.000037134912,0.000012139573,0.000017519103,0.00014296637,0.000028302551,0.0006989471],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998036,0.00005031159,0.000033429995,0.000026896078,0.00003745153,0.000048404952],"domain_scores_gemma":[0.99979967,0.000033664564,0.00007730399,0.000029093297,0.00002622109,0.000033964014],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025815231,0.0003175309,0.00035726838,0.00020008365,0.00016987597,0.0002648957,0.0005429819,0.00034080195,0.0011163141],"category_scores_gemma":[0.0004478263,0.00020657881,0.00026102253,0.00033772626,0.0002587072,0.00022331435,0.00017081837,0.000509507,0.0004453727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007639343,0.00008171188,0.00029766787,0.000052141022,0.000021186595,0.00027711716,0.000047305868,0.0008045718,0.99313194,0.00026497204,0.000063160776,0.0041942443],"study_design_scores_gemma":[0.00014327191,0.0011084481,0.0016572083,0.000011846679,0.00007015067,0.0005231506,0.000044565946,0.001435126,0.9928645,0.00006092896,0.0020602688,0.000020610005],"about_ca_topic_score_codex":0.0010136439,"about_ca_topic_score_gemma":0.002108017,"teacher_disagreement_score":0.0011163141,"about_ca_system_score_codex":0.00032923993,"about_ca_system_score_gemma":0.00047809488,"threshold_uncertainty_score":0.0037344098},"labels":[],"label_agreement":null},{"id":"W1966874851","doi":"10.1016/j.bmcl.2012.04.058","title":"Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Canada Research Chairs; McGill University Health Centre","keywords":"Chemistry; Identification (biology); Stereochemistry; Structure–activity relationship; Small molecule; Computational biology; Biochemistry; In vitro","score_opus":0.012400545076829899,"score_gpt":0.2152710237325195,"score_spread":0.2028704786556896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966874851","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.80328107,0.042320162,0.12479499,0.004137575,0.0012494959,0.0033871941,0.0023066427,0.0012228618,0.017300084],"genre_scores_gemma":[0.9319336,0.020685822,0.034294464,0.0011613556,0.000107916225,0.0009112315,0.0025303229,0.000058035384,0.008317258],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981827,0.000033345663,0.000011971808,0.0000350666,0.000052090174,0.00004930877],"domain_scores_gemma":[0.9998901,0.000019443365,0.000030306383,0.0000069332214,0.000027460128,0.0000258476],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00053739647,0.0009206828,0.00087732996,0.00052799,0.00032143624,0.0008324339,0.001009199,0.0005288752,0.0019145],"category_scores_gemma":[0.00033532394,0.0003910407,0.0007836833,0.00023288812,0.0003566715,0.00036551143,0.000415532,0.001343138,0.0005262759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018937861,0.0012772596,0.0012173232,0.00075746386,0.00031197417,0.000964941,0.00012607903,0.014392821,0.8875474,0.008709518,0.003725322,0.07907604],"study_design_scores_gemma":[0.0040938673,0.012917274,0.0019920808,0.0001280545,0.0006544277,0.001949008,0.000117443975,0.032977182,0.8653685,0.0027659861,0.07691224,0.0001238758],"about_ca_topic_score_codex":0.000526379,"about_ca_topic_score_gemma":0.0014860852,"teacher_disagreement_score":0.0019145,"about_ca_system_score_codex":0.0007859475,"about_ca_system_score_gemma":0.0005875713,"threshold_uncertainty_score":0.0064046383},"labels":[],"label_agreement":null},{"id":"W1966912675","doi":"10.1016/j.bmcl.2010.10.036","title":"4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Piperazine; Allosteric regulation; Chemistry; Metabotropic glutamate receptor 5; Piperidine; Allosteric modulator; Metabotropic glutamate receptor; Pharmacology; Aryl; Stereochemistry; Combinatorial chemistry; Structure–activity relationship; In vitro; Biochemistry; Receptor; Glutamate receptor; Organic chemistry; Biology","score_opus":0.018221154104748217,"score_gpt":0.2818427706359916,"score_spread":0.2636216165312434,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966912675","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95467794,0.018239774,0.005663428,0.00066638,0.00023850937,0.00015319536,0.00034503685,0.0003255235,0.01969019],"genre_scores_gemma":[0.97897357,0.008880869,0.0033664443,0.00027599165,0.00008372947,0.000057898353,0.00026776546,0.000019469348,0.008074317],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999542,0.0000112085,0.000003012021,0.000005806293,0.000008431285,0.000017341963],"domain_scores_gemma":[0.9999808,0.0000029317466,0.0000055758856,0.0000016726524,0.000002390559,0.0000065504414],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018852617,0.0003601141,0.00028176207,0.00015705632,0.00012950542,0.00015568978,0.0003590252,0.00022861434,0.0029710326],"category_scores_gemma":[0.00009521577,0.0001423637,0.00013895205,0.00012060915,0.00014634027,0.00025586758,0.00021582902,0.00041519408,0.0004633611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016708082,0.00020975394,0.00021182874,0.0005020371,0.000026182775,0.00072085013,0.00013137213,0.001426303,0.9320426,0.002586619,0.0016738034,0.05879767],"study_design_scores_gemma":[0.0014490514,0.014430148,0.0067043733,0.00010871691,0.00021892245,0.0023007218,0.00012779317,0.00811486,0.89113957,0.0010220857,0.07429469,0.00008909694],"about_ca_topic_score_codex":0.00037572757,"about_ca_topic_score_gemma":0.0012973314,"teacher_disagreement_score":0.0029710326,"about_ca_system_score_codex":0.00018583162,"about_ca_system_score_gemma":0.00011145736,"threshold_uncertainty_score":0.0099390745},"labels":[],"label_agreement":null},{"id":"W1967273981","doi":"10.1016/j.bmcl.2013.02.042","title":"Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Potency; Reverse transcriptase; Chemistry; Human immunodeficiency virus (HIV); Nucleotidyltransferase; Nucleotide; In vitro; Enzyme; Stereochemistry; Virology; Biochemistry; RNA; Biology","score_opus":0.008815738321974504,"score_gpt":0.20745604351950322,"score_spread":0.19864030519752873,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1967273981","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90319115,0.05287382,0.016280014,0.0011421635,0.00029391932,0.00067566993,0.0023825422,0.0003975401,0.022763256],"genre_scores_gemma":[0.9463824,0.02394402,0.014402085,0.000648453,0.000118377335,0.00026482024,0.002356817,0.0000358704,0.011847042],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988234,0.0000199376,0.0000063542825,0.000021667236,0.00003708731,0.000032692813],"domain_scores_gemma":[0.9999294,0.000010893271,0.000018629977,0.000005624374,0.000014913878,0.000020606347],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018076248,0.00044247654,0.00036332675,0.0004351846,0.00019307449,0.00045765782,0.00037655368,0.0003322161,0.0018247485],"category_scores_gemma":[0.00023036634,0.00018483214,0.0001924494,0.0002492558,0.00016693093,0.0002869148,0.00023599625,0.00051457563,0.0005151336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006870866,0.00034795786,0.0013635313,0.00047212548,0.000035287376,0.0006225119,0.00014650809,0.001529338,0.9069956,0.002480375,0.002216285,0.08310342],"study_design_scores_gemma":[0.000658688,0.0049967202,0.013849197,0.00012803686,0.00014690773,0.003153698,0.00009743606,0.0070854714,0.86614347,0.00072513334,0.102935106,0.00008014581],"about_ca_topic_score_codex":0.00062598917,"about_ca_topic_score_gemma":0.0023851309,"teacher_disagreement_score":0.0018247485,"about_ca_system_score_codex":0.00044745358,"about_ca_system_score_gemma":0.00043208105,"threshold_uncertainty_score":0.00610435},"labels":[],"label_agreement":null},{"id":"W1967603104","doi":"10.1016/j.bmcl.2014.12.063","title":"Biofilm inhibition of linezolid-like Schiff bases: Synthesis, biological activity, molecular docking and in silico ADME prediction","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Atlantic Canada Opportunities Agency; University of the Punjab","keywords":"ADME; Chemistry; Linezolid; Biofilm; Quorum sensing; IC50; Minimum inhibitory concentration; Docking (animal); Antibacterial activity; Combinatorial chemistry; In silico; Pseudomonas aeruginosa; Antibacterial agent; Ciprofloxacin; Stereochemistry; In vitro; Biochemistry; Bacteria; Antibiotics; Staphylococcus aureus; Biology; Vancomycin","score_opus":0.008216722290198607,"score_gpt":0.21203500633555525,"score_spread":0.20381828404535665,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1967603104","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9631655,0.004986687,0.02579989,0.00038812048,0.000060128204,0.00012317227,0.0010716703,0.00034223986,0.0040624766],"genre_scores_gemma":[0.9777078,0.0020802685,0.01793883,0.000056539844,0.000006431183,0.000050890158,0.0006361003,0.000028576864,0.0014945387],"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998833,0.000034088414,0.0000055624996,0.000023620509,0.00003068521,0.000022700311],"domain_scores_gemma":[0.99987733,0.000039733655,0.000028177854,0.000009023972,0.000028067703,0.000017809487],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044651856,0.0007788464,0.00074506167,0.00026329808,0.00022231246,0.00046633856,0.0006126551,0.00042873024,0.0013148949],"category_scores_gemma":[0.0005348302,0.00030270577,0.0006822402,0.00024161651,0.00013316149,0.00025353752,0.00025593833,0.0007508318,0.0003058215],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024683333,0.0009190307,0.0035569635,0.0014022596,0.000447408,0.0007526337,0.00013102389,0.5331367,0.38112772,0.004570188,0.003069517,0.068418235],"study_design_scores_gemma":[0.00045931936,0.003671019,0.0012180128,0.00006428293,0.00034162047,0.00025900983,0.00006350536,0.68339556,0.30474094,0.0005661453,0.0051244837,0.00009614855],"about_ca_topic_score_codex":0.0028885328,"about_ca_topic_score_gemma":0.0045589716,"teacher_disagreement_score":0.0028885328,"about_ca_system_score_codex":0.000715088,"about_ca_system_score_gemma":0.0005001325,"threshold_uncertainty_score":0.0057435036},"labels":[],"label_agreement":null},{"id":"W1967764146","doi":"10.1016/j.bmcl.2005.01.054","title":"3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Multiple drug resistance; Toxicity; Aryl; Stereochemistry; In vitro; Chemical synthesis; Pharmacology; Combinatorial chemistry; Biochemistry; Organic chemistry; Antibiotics; Alkyl","score_opus":0.006594787971122128,"score_gpt":0.20079130829935965,"score_spread":0.19419652032823753,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1967764146","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95828354,0.0112259975,0.0043939403,0.0002906446,0.00012038334,0.00008251517,0.0005198163,0.00016237506,0.024920754],"genre_scores_gemma":[0.98571044,0.005020903,0.0017653558,0.00009772544,0.000042357406,0.00009013318,0.000357184,0.00001551942,0.006900395],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992836,0.000019474617,0.000004641465,0.000009940318,0.000014926298,0.000022730992],"domain_scores_gemma":[0.99996305,0.000009555768,0.000009897225,0.0000048391094,0.000004482018,0.000008080923],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011663917,0.00024159878,0.0002496587,0.00025391055,0.00019854867,0.00014996118,0.00035895727,0.00022276124,0.0018889909],"category_scores_gemma":[0.00012291707,0.00011857396,0.00012510348,0.0001582902,0.00015645634,0.00021979907,0.00018445733,0.00028219412,0.0005148692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005110859,0.00014314456,0.00022615229,0.00017832697,0.000013371156,0.00043008884,0.000113870614,0.00070615025,0.98036045,0.0031301551,0.00050335354,0.01368397],"study_design_scores_gemma":[0.0001374606,0.0022265061,0.004899456,0.000025658339,0.000032607495,0.001476601,0.00006942898,0.0013541332,0.96749026,0.0005206821,0.02174589,0.000021251923],"about_ca_topic_score_codex":0.00053782307,"about_ca_topic_score_gemma":0.0012047791,"teacher_disagreement_score":0.0018889909,"about_ca_system_score_codex":0.00023029758,"about_ca_system_score_gemma":0.00018628278,"threshold_uncertainty_score":0.0063192844},"labels":[],"label_agreement":null},{"id":"W1967959358","doi":"10.1016/j.bmcl.2014.11.047","title":"Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; National Institute of Mental Health","keywords":"Pharmacophore; Chemistry; Neurotensin; Agonist; G protein-coupled receptor; Receptor; Chemical synthesis; Stereochemistry; Pharmacology; Partial agonist; Structure–activity relationship; Neurotensin receptor; Biochemistry; In vitro; Neuropeptide; Medicine","score_opus":0.021838537124017787,"score_gpt":0.2515110958124164,"score_spread":0.2296725586883986,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1967959358","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9894427,0.0020676784,0.0041582305,0.00018807288,0.000050657858,0.0000720176,0.00054999423,0.00008232312,0.0033883369],"genre_scores_gemma":[0.98923475,0.0009395801,0.004437913,0.00016415142,0.000029485456,0.000053977674,0.0010630534,0.000015340973,0.004061712],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994636,0.000007819183,0.0000029882412,0.000012194228,0.000013178894,0.000017444436],"domain_scores_gemma":[0.9999467,0.000008296859,0.000013517262,0.0000033128981,0.000009555921,0.000018723007],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007888067,0.00028820772,0.00025149208,0.0001838333,0.000117015494,0.00014804836,0.00030275367,0.00027808134,0.00142768],"category_scores_gemma":[0.00012547635,0.000105177125,0.00014770715,0.00007795357,0.00013849871,0.00015072915,0.00015757699,0.00020366335,0.00052846153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021338213,0.000016847212,0.00015343283,0.000025152498,0.0000021043286,0.00016408796,0.000010826212,0.000050310926,0.99739707,0.00005271504,0.000049993963,0.001864051],"study_design_scores_gemma":[0.00019065714,0.0016251823,0.010634656,0.000010964019,0.000025292642,0.0026774881,0.000046971214,0.0015333085,0.9755347,0.00010893652,0.0075932587,0.00001877325],"about_ca_topic_score_codex":0.000666844,"about_ca_topic_score_gemma":0.0009793334,"teacher_disagreement_score":0.00142768,"about_ca_system_score_codex":0.00023776354,"about_ca_system_score_gemma":0.00019813413,"threshold_uncertainty_score":0.0047760606},"labels":[],"label_agreement":null},{"id":"W1968698908","doi":"10.1016/j.bmcl.2006.11.077","title":"Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: Identification of SKS-927","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Quinoline; Aniline; Amine gas treating; Stereochemistry; Kinase; Proto-oncogene tyrosine-protein kinase Src; Inhibitory postsynaptic potential; Structure–activity relationship; Aromatic amine; Aniline Compounds; Biochemistry; In vitro; Organic chemistry; Internal medicine","score_opus":0.007450620211774933,"score_gpt":0.23002168004746237,"score_spread":0.22257105983568745,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1968698908","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98668414,0.0042701727,0.0040514306,0.00024395825,0.00004001327,0.000107303706,0.00036323196,0.00009114776,0.004148536],"genre_scores_gemma":[0.99182373,0.00235097,0.0018237096,0.00007004173,0.00001483978,0.000058277834,0.0007768907,0.000015261601,0.0030662648],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989605,0.0000221576,0.000007774577,0.00001079211,0.000026072004,0.00003716121],"domain_scores_gemma":[0.9999378,0.000018407414,0.000014223687,0.0000075416465,0.000011626251,0.0000104184055],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027248773,0.00031481832,0.00034052006,0.00022392007,0.00015585196,0.00020178244,0.0003430741,0.00027268368,0.0014263598],"category_scores_gemma":[0.00014875633,0.000150123,0.00031279767,0.00012330954,0.00018608183,0.00017411266,0.00015478536,0.0004890048,0.00061773084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005016674,0.00009915343,0.00028622866,0.00005824368,0.000011697953,0.00023353886,0.000023665514,0.00022024203,0.99308187,0.00031399724,0.0001268002,0.0050428016],"study_design_scores_gemma":[0.00013045342,0.0010275597,0.0032092952,0.000007738245,0.000023947274,0.00066147384,0.000023427052,0.001087113,0.9911163,0.000070937196,0.002631589,0.000010247334],"about_ca_topic_score_codex":0.0006462384,"about_ca_topic_score_gemma":0.001009487,"teacher_disagreement_score":0.0014263598,"about_ca_system_score_codex":0.0002391276,"about_ca_system_score_gemma":0.00030611057,"threshold_uncertainty_score":0.00477165},"labels":[],"label_agreement":null},{"id":"W1968917502","doi":"10.1016/j.bmcl.2008.08.088","title":"Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences; Brock University","funders":"","keywords":"Chemistry; Phosphonate; Chemical synthesis; Stereochemistry; Combinatorial chemistry; In vitro; Biochemistry","score_opus":0.016208640514857396,"score_gpt":0.17568182916021602,"score_spread":0.15947318864535862,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1968917502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9884505,0.0016914578,0.0026349074,0.00013359135,0.00006234614,0.00006697381,0.00027460122,0.00007002074,0.0066156243],"genre_scores_gemma":[0.9944772,0.00092308584,0.001602996,0.000071700364,0.000020173336,0.000035679863,0.0002601886,0.000014207419,0.002594842],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999198,0.000017775932,0.0000064762007,0.000013519462,0.000011679574,0.00003079054],"domain_scores_gemma":[0.99993074,0.00001369575,0.000015533384,0.000009415428,0.000008871232,0.000021833774],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016827928,0.00025156763,0.00018766086,0.00013032291,0.0001397028,0.00022644042,0.00031452882,0.00024133401,0.0024636304],"category_scores_gemma":[0.00020720692,0.00011294321,0.00017659522,0.00015721185,0.00020719861,0.00019519095,0.00021676818,0.0004946749,0.00039901925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00071220496,0.00006103168,0.00007290652,0.00012891435,0.000009559452,0.00022370626,0.000055512402,0.0006160494,0.9917624,0.0004631152,0.00016048011,0.00573402],"study_design_scores_gemma":[0.00011678416,0.0011334962,0.00044506355,0.0000056100885,0.000021800213,0.00027993112,0.0000193995,0.00045206517,0.99358374,0.000054285338,0.0038795834,0.00000823586],"about_ca_topic_score_codex":0.00053970155,"about_ca_topic_score_gemma":0.00040610417,"teacher_disagreement_score":0.0024636304,"about_ca_system_score_codex":0.000216087,"about_ca_system_score_gemma":0.00020902794,"threshold_uncertainty_score":0.008241713},"labels":[],"label_agreement":null},{"id":"W1969190154","doi":"10.1016/j.bmcl.2012.01.031","title":"3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NeurAxon (Canada)","funders":"","keywords":"Chemistry; Enos; Nitric oxide synthase; Indole test; Amidine; Gene isoform; Stereochemistry; Amine gas treating; Selectivity; Nitric oxide; Endothelial NOS; Carboxamide; Enzyme inhibitor; Structure–activity relationship; Biochemistry; In vitro; Enzyme; Organic chemistry","score_opus":0.01322582948354404,"score_gpt":0.263362765454281,"score_spread":0.25013693597073694,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1969190154","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96529347,0.014035696,0.005352328,0.00021677383,0.00024253264,0.0000753427,0.00052629464,0.0002028737,0.014054615],"genre_scores_gemma":[0.9893845,0.0041085584,0.0016336484,0.00008379731,0.00002413174,0.000027711407,0.00029842506,0.000014352296,0.0044248533],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999428,0.000013128982,0.0000037679863,0.0000072367516,0.000010915576,0.000022059578],"domain_scores_gemma":[0.9999764,0.00000407048,0.000004830846,0.0000025250765,0.000003780358,0.000008316172],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014719352,0.00022871069,0.00017549255,0.00015109034,0.0001385106,0.00012959189,0.00031721592,0.00020703075,0.0013574383],"category_scores_gemma":[0.00007010168,0.00007621395,0.00014508024,0.00013087857,0.00010952467,0.00013205041,0.00011171422,0.0002900035,0.00026690122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080055435,0.0001530285,0.00021810886,0.00014743522,0.000017774664,0.00032847733,0.00006568569,0.00087282324,0.9808183,0.0014361714,0.0006985367,0.014443116],"study_design_scores_gemma":[0.00017348745,0.003063724,0.0028302625,0.000025053065,0.000065895336,0.0004631254,0.000039360442,0.002539604,0.97386646,0.00019620325,0.016713247,0.000023620532],"about_ca_topic_score_codex":0.00088524295,"about_ca_topic_score_gemma":0.0030826926,"teacher_disagreement_score":0.0013574383,"about_ca_system_score_codex":0.00022859036,"about_ca_system_score_gemma":0.00017095704,"threshold_uncertainty_score":0.004541099},"labels":[],"label_agreement":null},{"id":"W1969269185","doi":"10.1016/j.bmcl.2005.04.013","title":"Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Estrogen receptor; Selectivity; Ligand (biochemistry); Stereochemistry; Chemical synthesis; Potency; Estrogen; Molecular model; Structure–activity relationship; Receptor; Combinatorial chemistry; Biochemistry; In vitro; Internal medicine","score_opus":0.007156200114273742,"score_gpt":0.2132046490312964,"score_spread":0.20604844891702268,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1969269185","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8745587,0.034959406,0.05095554,0.0015794152,0.00055633625,0.0005700613,0.0018017647,0.0005205024,0.034498356],"genre_scores_gemma":[0.91618645,0.027549747,0.026912102,0.00074597914,0.00011314825,0.00040574395,0.0012985155,0.00008235103,0.026705824],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999268,0.00001597923,0.0000074643153,0.00001438724,0.000013670081,0.000021646636],"domain_scores_gemma":[0.9999542,0.000007731664,0.000011956445,0.0000031699892,0.00000776296,0.000015255237],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022625804,0.0003758565,0.0002698813,0.00024625563,0.00016931999,0.00026505865,0.00044317008,0.00023822261,0.003494449],"category_scores_gemma":[0.00017451306,0.00019474256,0.00019659798,0.000177384,0.00015947172,0.00041250032,0.00032854135,0.00043073852,0.0011315262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00087761343,0.00041214155,0.0006579901,0.001262283,0.000046599365,0.00093292096,0.00041811317,0.0067309435,0.87717724,0.015226388,0.003273173,0.0929846],"study_design_scores_gemma":[0.0005685991,0.0037415957,0.0027282166,0.00014715188,0.00006953204,0.0013875343,0.00019108834,0.006157507,0.84497565,0.002601446,0.13731734,0.000114343915],"about_ca_topic_score_codex":0.00020381993,"about_ca_topic_score_gemma":0.0007681868,"teacher_disagreement_score":0.003494449,"about_ca_system_score_codex":0.00027257425,"about_ca_system_score_gemma":0.00030084432,"threshold_uncertainty_score":0.01169008},"labels":[],"label_agreement":null},{"id":"W1969694437","doi":"10.1016/j.bmcl.2010.04.016","title":"Tricyclic imidazole antagonists of the Neuropeptide S Receptor","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Antagonism; Tricyclic; Antagonist; G protein-coupled receptor; Pharmacology; Receptor; In vivo; Stereochemistry; Biochemistry; Biology","score_opus":0.010326168780141285,"score_gpt":0.2158271920662603,"score_spread":0.20550102328611902,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1969694437","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97816616,0.0064611835,0.0024127178,0.00032507544,0.0001675103,0.0000427292,0.0002402538,0.00018578036,0.011998607],"genre_scores_gemma":[0.98940253,0.003941295,0.0009372249,0.00015946952,0.000054941484,0.00002033473,0.0002501886,0.000010873584,0.005223063],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999335,0.000011690331,0.0000051047705,0.0000060859543,0.000011500368,0.00003217944],"domain_scores_gemma":[0.9999702,0.0000057922603,0.00000815025,0.0000032922264,0.0000035358316,0.000009091915],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011072103,0.0002062871,0.00034599804,0.0001422493,0.0001268698,0.00020318407,0.00048427473,0.00016590396,0.003124648],"category_scores_gemma":[0.00015906275,0.00009383847,0.00011706136,0.00012956731,0.00014740015,0.00014407428,0.000110776054,0.00037804857,0.0004958154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.004102017,0.00026359613,0.0005426916,0.0003179373,0.00008279941,0.0007566513,0.00009274032,0.0015747409,0.922038,0.0038238645,0.0030626848,0.06334231],"study_design_scores_gemma":[0.0032968286,0.014689404,0.009298223,0.00007330259,0.00022235837,0.0045216265,0.00018509888,0.013525403,0.91906905,0.0016801803,0.0333461,0.00009248005],"about_ca_topic_score_codex":0.00066149095,"about_ca_topic_score_gemma":0.0021860828,"teacher_disagreement_score":0.003124648,"about_ca_system_score_codex":0.00033908643,"about_ca_system_score_gemma":0.0001523491,"threshold_uncertainty_score":0.010452986},"labels":[],"label_agreement":null},{"id":"W1969754337","doi":"10.1016/j.bmcl.2007.12.013","title":"Targeting ACE and ECE with dual acting inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Reaction Mechanisms","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Enzyme inhibitor; Pharmacology; ACE inhibitor; Stereochemistry; Enzyme; Biochemistry; Angiotensin-converting enzyme; Endocrinology","score_opus":0.006546239030506034,"score_gpt":0.21259754400265085,"score_spread":0.20605130497214483,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1969754337","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8313963,0.043747924,0.085994355,0.002424497,0.0007865584,0.00028125365,0.00050153857,0.00063879637,0.034228787],"genre_scores_gemma":[0.9683382,0.008343872,0.008213943,0.00033681706,0.00014389142,0.00008755065,0.00024174017,0.00003066565,0.014263236],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983597,0.00003112638,0.00000926135,0.000027016311,0.000042137293,0.000054320015],"domain_scores_gemma":[0.99993,0.000019395027,0.000016402866,0.000007676901,0.000009300219,0.000017203554],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003815921,0.0004780425,0.00046196196,0.00023056805,0.00012666611,0.0006327538,0.0003668796,0.00043764448,0.001884294],"category_scores_gemma":[0.00021206343,0.000205466,0.00025544566,0.00013644673,0.00020500417,0.000528187,0.00034091764,0.00096762186,0.00065232645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011118081,0.00023314722,0.0004508622,0.00024502832,0.000071114235,0.0005176938,0.000040915435,0.0015219314,0.9349646,0.0066385744,0.001612553,0.052591894],"study_design_scores_gemma":[0.0002238373,0.0007609818,0.00053608586,0.00001054272,0.00007649666,0.001391608,0.000016992637,0.0049489234,0.95912105,0.0008077008,0.03208972,0.000016006994],"about_ca_topic_score_codex":0.00014286087,"about_ca_topic_score_gemma":0.00034222248,"teacher_disagreement_score":0.001884294,"about_ca_system_score_codex":0.000336292,"about_ca_system_score_gemma":0.00015578943,"threshold_uncertainty_score":0.006303549},"labels":[],"label_agreement":null},{"id":"W1969782664","doi":"10.1016/j.bmcl.2008.01.124","title":"Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols—A proof-of-concept study","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Austrian Science Fund","keywords":"Glycoside hydrolase; Iminosugar; Chemistry; Hydrolase; Enzyme; Biochemistry; Combinatorial chemistry","score_opus":0.016680690021780575,"score_gpt":0.25024551297684366,"score_spread":0.2335648229550631,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1969782664","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9676204,0.0017782354,0.028493488,0.00015617842,0.000059599017,0.00020551047,0.0002434992,0.00016425605,0.0012787639],"genre_scores_gemma":[0.9736251,0.0018520444,0.021723386,0.000057323858,0.000016607588,0.0000815027,0.00033932264,0.000031896587,0.0022727717],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998099,0.0000333821,0.000011181304,0.00004233961,0.00006036698,0.00004282138],"domain_scores_gemma":[0.9998851,0.00003334194,0.000024495452,0.000014929253,0.000025816282,0.000016247626],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054578023,0.00069328194,0.00045549864,0.00019340191,0.00019996484,0.0004717296,0.00053748663,0.0004355951,0.00047489256],"category_scores_gemma":[0.00026231958,0.00023732147,0.00031622368,0.00028460205,0.0003227542,0.00043028238,0.0001744944,0.0007619086,0.00026250997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007134029,0.000030105772,0.00002217129,0.000026014104,0.0000044604053,0.000028021335,0.000012353405,0.00006327021,0.99893695,0.000050317383,0.000014982757,0.00073999976],"study_design_scores_gemma":[0.0000053002946,0.00010053105,0.00008003951,5.4977613e-7,0.0000050176245,0.00002922104,0.0000052859737,0.00020730082,0.99935454,0.000006569968,0.00020355762,0.0000021488408],"about_ca_topic_score_codex":0.0005776211,"about_ca_topic_score_gemma":0.0006583127,"teacher_disagreement_score":0.00069328194,"about_ca_system_score_codex":0.00044909556,"about_ca_system_score_gemma":0.00020836611,"threshold_uncertainty_score":0.003258407},"labels":[],"label_agreement":null},{"id":"W1969836953","doi":"10.1016/j.bmcl.2014.12.028","title":"Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Chemistry; Pharmacology; Metabolite; NS5B; Potency; Stereochemistry; Polymerase; In vivo; Biochemistry; In vitro; Hepacivirus; Enzyme; Genotype; Medicine; Biology; Genetics","score_opus":0.017252620296147412,"score_gpt":0.27751132931329464,"score_spread":0.2602587090171472,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1969836953","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98870087,0.004518898,0.000872054,0.00028430147,0.00014789269,0.0001679,0.0008925733,0.00015234492,0.004263028],"genre_scores_gemma":[0.99194545,0.0016232536,0.00047596346,0.00017851983,0.000030842122,0.000051718067,0.0009902543,0.00002088708,0.004683152],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998734,0.000029066157,0.0000092948785,0.000022766537,0.000018603634,0.00004690192],"domain_scores_gemma":[0.99989474,0.000023953156,0.0000205135,0.000018938028,0.000014254388,0.000027533706],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018706417,0.00026678675,0.0005148148,0.00023968685,0.00029810565,0.0002250163,0.0003784165,0.00040689606,0.0066757984],"category_scores_gemma":[0.00040108836,0.000118502074,0.0003861282,0.00019602483,0.00015174235,0.00023020605,0.00015110777,0.0005957533,0.00077116315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.026249234,0.0032100615,0.0045400644,0.00039203267,0.00040483827,0.00088521716,0.00017308949,0.002346514,0.7571622,0.00047261408,0.0051285117,0.19903551],"study_design_scores_gemma":[0.0030997922,0.08350182,0.06511604,0.00009456339,0.0009833989,0.0027951205,0.0001827704,0.0041164327,0.81055486,0.00051457144,0.02894033,0.0001004519],"about_ca_topic_score_codex":0.0012602336,"about_ca_topic_score_gemma":0.0025752834,"teacher_disagreement_score":0.0066757984,"about_ca_system_score_codex":0.00025500375,"about_ca_system_score_gemma":0.00025902706,"threshold_uncertainty_score":0.022332788},"labels":[],"label_agreement":null},{"id":"W1970010625","doi":"10.1016/j.bmcl.2010.07.030","title":"Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; CYP3A4; Renin inhibitor; Moiety; Stereochemistry; Renin–angiotensin system; Amide; Drug; Pharmacology; Biochemistry; Combinatorial chemistry; Cytochrome P450; Enzyme; Internal medicine","score_opus":0.12045615350016277,"score_gpt":0.3734272187967631,"score_spread":0.25297106529660035,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970010625","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98959154,0.002086451,0.0032677904,0.00050853105,0.0000526717,0.000044736356,0.00006647275,0.000053407108,0.004328452],"genre_scores_gemma":[0.9971775,0.0008826135,0.00063823024,0.00011485345,0.00005003002,0.0000059353647,0.00003745204,0.000010201117,0.001083133],"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998287,0.000039882474,0.000016772607,0.000035125475,0.000048296286,0.000031158528],"domain_scores_gemma":[0.9996704,0.00013513467,0.00007969564,0.00003951546,0.000024519102,0.000050663137],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025166597,0.00021497648,0.00028583605,0.00022186336,0.0002638889,0.00030408142,0.00029524267,0.0006118343,0.0005888784],"category_scores_gemma":[0.0008873102,0.00008419123,0.00032160513,0.00019479066,0.00037379208,0.00024459796,0.00011057375,0.00082446844,0.00016507268],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0047148815,0.0018784147,0.052638628,0.00032596564,0.00023624214,0.42204764,0.0010388361,0.002476461,0.3691475,0.0031845598,0.0017352741,0.14057562],"study_design_scores_gemma":[0.000263922,0.02076122,0.051989663,0.000024758996,0.0004737733,0.5994128,0.00034876133,0.007358081,0.2936615,0.0010862717,0.024554344,0.00006495292],"about_ca_topic_score_codex":0.0005596083,"about_ca_topic_score_gemma":0.0009483994,"teacher_disagreement_score":0.0006118343,"about_ca_system_score_codex":0.0002743388,"about_ca_system_score_gemma":0.00017629137,"threshold_uncertainty_score":0.001990497},"labels":[],"label_agreement":null},{"id":"W1970501423","doi":"10.1016/s0960-894x(01)00789-2","title":"Synthesis of an α-Aminophosphonate Nucleoside as an Inhibitor of S-Adenosyl-l-Homocysteine Hydrolase","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Hydrolase; Epimer; Plasma homocysteine; Stereochemistry; Nucleoside; Homocysteine; Enzyme inhibitor; Enzyme; Biochemistry","score_opus":0.014205386565249705,"score_gpt":0.24936141954259755,"score_spread":0.23515603297734786,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970501423","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90810275,0.011275032,0.044391885,0.000709422,0.0005586562,0.00042863446,0.0011445916,0.0007140757,0.032674924],"genre_scores_gemma":[0.97483665,0.003564197,0.014282421,0.00010002408,0.000042174343,0.00006745769,0.00070579315,0.00004440311,0.00635682],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998679,0.000027668844,0.000016122494,0.000028240971,0.000024678888,0.00003536814],"domain_scores_gemma":[0.9998921,0.000023780201,0.00001803896,0.000011768394,0.000018449278,0.00003582668],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023064588,0.00053959637,0.00037571572,0.00026318914,0.0003156451,0.00043308188,0.0005397103,0.0006418469,0.0015882615],"category_scores_gemma":[0.00024110267,0.0002473135,0.00029140702,0.00021624776,0.00018394516,0.0002584947,0.00023989285,0.0006023593,0.00060926226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003717743,0.00009325584,0.00009104016,0.00017336331,0.000027953734,0.00049314206,0.000044348573,0.0011622092,0.98620194,0.0013825624,0.00023785363,0.009720596],"study_design_scores_gemma":[0.000040802413,0.00039639548,0.00015690182,0.0000064999335,0.00003102048,0.0002490782,0.000007445483,0.0010879523,0.9913264,0.00010233592,0.006585682,0.000009545476],"about_ca_topic_score_codex":0.001165233,"about_ca_topic_score_gemma":0.0010105353,"teacher_disagreement_score":0.0015882615,"about_ca_system_score_codex":0.00043570698,"about_ca_system_score_gemma":0.00063231314,"threshold_uncertainty_score":0.0053132176},"labels":[],"label_agreement":null},{"id":"W1970558662","doi":"10.1016/j.bmcl.2010.06.022","title":"Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Prodrug; Nitric oxide; Moiety; Stereochemistry; Deamidation; Celecoxib; Enzyme; Biochemistry; Organic chemistry","score_opus":0.022565250613846163,"score_gpt":0.2836653085655373,"score_spread":0.2611000579516911,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970558662","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930385,0.0019581346,0.0027775846,0.000047099256,0.000031080723,0.00009612124,0.00012370093,0.000033932443,0.0018938339],"genre_scores_gemma":[0.9937802,0.0011832308,0.002882767,0.000038451006,0.000013447784,0.00004054761,0.0002210916,0.0000063172142,0.0018338615],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994874,0.000012082744,0.0000043083874,0.0000076931465,0.000012098842,0.000015119153],"domain_scores_gemma":[0.9999583,0.000008880619,0.000010816018,0.0000045960574,0.000005307813,0.000012016622],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196355,0.00021818941,0.00020514925,0.00015328269,0.00012600223,0.00010797386,0.000160896,0.00018358842,0.00047454637],"category_scores_gemma":[0.00014656245,0.00010502039,0.00013435428,0.00009453435,0.00011584067,0.0001528285,0.00007383117,0.0002189883,0.00012851378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00061705406,0.00012941868,0.000101044294,0.00006779201,0.000006433479,0.00017820919,0.000027604592,0.00026409718,0.992546,0.00023479972,0.000057785688,0.0057698023],"study_design_scores_gemma":[0.00023573657,0.0039694295,0.0010531949,0.000007637354,0.00003296379,0.00031529908,0.000012794651,0.00061715464,0.9913119,0.000039882536,0.00239772,0.000006377349],"about_ca_topic_score_codex":0.00034225936,"about_ca_topic_score_gemma":0.0006410512,"teacher_disagreement_score":0.00047454637,"about_ca_system_score_codex":0.00014910895,"about_ca_system_score_gemma":0.00015533819,"threshold_uncertainty_score":0.0015875101},"labels":[],"label_agreement":null},{"id":"W1970642599","doi":"10.1016/j.bmcl.2012.01.025","title":"Neomycin–phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences Centre; Manitoba Health; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Manitoba Health Research Council","keywords":"Chemistry; Amphiphile; Cationic polymerization; Antimicrobial; Conjugate; Antibacterial activity; Hemolysis; Combinatorial chemistry; Neomycin; Azide; Stereochemistry; Biochemistry; Bacteria; Organic chemistry; Antibiotics; Polymer; Copolymer","score_opus":0.007411162845659755,"score_gpt":0.20003059366800383,"score_spread":0.19261943082234406,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970642599","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9943386,0.00057341496,0.0036171486,0.000084274914,0.00001858231,0.00002970932,0.00008291133,0.000047394475,0.0012080002],"genre_scores_gemma":[0.99498606,0.0002895691,0.0024312483,0.000075667755,0.000010908003,0.000036078432,0.00011517737,0.000015689873,0.0020394826],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998971,0.000022276994,0.000009999365,0.000019521241,0.000024443752,0.00002657599],"domain_scores_gemma":[0.9998282,0.00002817354,0.000060121496,0.000020886024,0.000023295777,0.000039334594],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015147014,0.00036708877,0.00014592113,0.00013235612,0.00011339591,0.0001835107,0.00013040134,0.00039407567,0.00074357534],"category_scores_gemma":[0.00023144553,0.00014079674,0.00011589171,0.00010957544,0.00019790076,0.0002586039,0.0002517651,0.00028889635,0.00031614833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012475933,0.000012280209,0.00007960327,0.00002348168,0.0000021489545,0.000029822631,0.0000068546337,0.000050285034,0.9983347,0.00007067136,0.000024329918,0.0012410814],"study_design_scores_gemma":[0.000015519652,0.00019011494,0.00092210295,0.0000024466524,0.000008114993,0.00020364324,0.000003829353,0.0002147935,0.9970222,0.000020254745,0.0013940532,0.0000028281477],"about_ca_topic_score_codex":0.00014790276,"about_ca_topic_score_gemma":0.00019881218,"teacher_disagreement_score":0.00074357534,"about_ca_system_score_codex":0.00020594455,"about_ca_system_score_gemma":0.00016233455,"threshold_uncertainty_score":0.0024874806},"labels":[],"label_agreement":null},{"id":"W1970710929","doi":"10.1016/j.bmcl.2013.04.060","title":"2-Fluoropyridine prosthetic compounds for the 18F labeling of bombesin analogues","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University; Université de Sherbrooke; BC Cancer Agency; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; TRIUMF","keywords":"Chemistry; Bombesin; Lipophilicity; Peptide; Azide; Cycloaddition; Combinatorial chemistry; Dipeptide; Click chemistry; Stereochemistry; Yield (engineering); Alkyne; Nucleophile; Conjugated system; Receptor; Organic chemistry; Biochemistry; Catalysis","score_opus":0.014091305253201947,"score_gpt":0.22816208950082312,"score_spread":0.21407078424762116,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970710929","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9383602,0.010753627,0.034194537,0.00040068166,0.00019033939,0.0002872507,0.0011412242,0.000509618,0.0141624855],"genre_scores_gemma":[0.96758187,0.003690201,0.021754691,0.00015039774,0.000039642422,0.00017993044,0.0010325611,0.00008730008,0.005483329],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978274,0.000058041765,0.000012172505,0.000051111983,0.000027180107,0.00006874715],"domain_scores_gemma":[0.9998878,0.000030279043,0.00002268611,0.000021548123,0.000011240178,0.00002652356],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046497985,0.00046525162,0.0003969799,0.00034212496,0.00024041811,0.00036019596,0.00058268005,0.0005364384,0.0025335057],"category_scores_gemma":[0.0003617559,0.00026810606,0.00021900248,0.00023065203,0.0002568886,0.0004767094,0.0002912523,0.00056574086,0.0006884431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006965186,0.00006381305,0.00014459182,0.00017074768,0.000015893265,0.0002992146,0.00010539672,0.0006028771,0.98543847,0.001381305,0.00055252993,0.010528758],"study_design_scores_gemma":[0.00007720174,0.0005364886,0.0005051258,0.000013931482,0.000020416275,0.00043757973,0.000015781077,0.0007345525,0.9838929,0.0000728388,0.013674949,0.000018201712],"about_ca_topic_score_codex":0.00094520784,"about_ca_topic_score_gemma":0.0014808401,"teacher_disagreement_score":0.0025335057,"about_ca_system_score_codex":0.0006450277,"about_ca_system_score_gemma":0.00025050325,"threshold_uncertainty_score":0.008475363},"labels":[],"label_agreement":null},{"id":"W1970733335","doi":"10.1016/j.bmcl.2015.01.044","title":"Combined molecular dynamics, STD-NMR, and CORCEMA protocol yields structural model for a UDP-galactopyranose mutase–inhibitor complex","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Western Canada Research Grid","keywords":"Chemistry; Mutase; Stereochemistry; Nuclear magnetic resonance spectroscopy; Molecular model; Molecular dynamics; Affinities; Enzyme; Biochemistry; Computational chemistry","score_opus":0.02898186275128382,"score_gpt":0.26236420026856744,"score_spread":0.23338233751728363,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970733335","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85046154,0.0011201093,0.11913635,0.0013388296,0.00021219737,0.00030742754,0.006622137,0.0029072645,0.017894158],"genre_scores_gemma":[0.9437701,0.0013263667,0.043944307,0.00014123779,0.000013988717,0.0003417639,0.0046685818,0.00032647685,0.005467203],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99991107,0.000009686824,0.000004603456,0.000026065485,0.000027085132,0.000021446587],"domain_scores_gemma":[0.9999368,0.000017052073,0.000010662267,0.000014640653,0.000010565984,0.00001029904],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016345254,0.00066037127,0.0005304046,0.00014638997,0.0005022549,0.0003111339,0.0011084345,0.00044143887,0.0035276483],"category_scores_gemma":[0.00030305545,0.00026960534,0.0002348114,0.0002605275,0.00026110242,0.0004311814,0.00020637525,0.0014402734,0.00073228625],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005585662,0.00016190979,0.00050852064,0.00025384178,0.000039796014,0.0006023021,0.00016028987,0.02700917,0.9432613,0.009428861,0.0038368956,0.014178527],"study_design_scores_gemma":[0.000089957946,0.00012667208,0.00044662497,0.000010004787,0.000030663912,0.00015625304,0.000038058526,0.080416635,0.9074067,0.0012828454,0.009940643,0.000054940494],"about_ca_topic_score_codex":0.0038963992,"about_ca_topic_score_gemma":0.004296578,"teacher_disagreement_score":0.0038963992,"about_ca_system_score_codex":0.0009227207,"about_ca_system_score_gemma":0.0008588863,"threshold_uncertainty_score":0.011801124},"labels":[],"label_agreement":null},{"id":"W1970926044","doi":"10.1016/j.bmcl.2010.08.120","title":"Antiviral activity of 2,3′-anhydro and related pyrimidine nucleosides against hepatitis B virus","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pyrimidine; Nucleoside; Hepatitis B virus; Nucleoside analogue; Pyrimidine analogue; Virus; Stereochemistry; Hepadnaviridae; Virology; Biology","score_opus":0.008524934576629721,"score_gpt":0.23337846352122749,"score_spread":0.22485352894459776,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970926044","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99476457,0.0028478743,0.00024360957,0.00002428748,0.00001571789,0.000011204148,0.00007491337,0.000011156615,0.0020066171],"genre_scores_gemma":[0.99748224,0.00096122106,0.0004748303,0.00003006107,0.000013966051,0.0000072774574,0.0001501008,0.00000350327,0.0008768455],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992764,0.000035730845,0.000005192968,0.0000070925184,0.000009454595,0.000014839621],"domain_scores_gemma":[0.9999176,0.000035756053,0.000011702706,0.000006416726,0.0000069044386,0.000021549506],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016950155,0.00014213676,0.00018676333,0.00022926876,0.00015168304,0.00014136202,0.00014709882,0.00019180951,0.0015852993],"category_scores_gemma":[0.00020747221,0.00009566244,0.00012528518,0.00012685105,0.00015230407,0.00014608988,0.00009130261,0.0002312843,0.00015822893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017322265,0.00011169593,0.00042057113,0.00013208286,0.000017527456,0.00013204696,0.000102152306,0.0007632107,0.9880229,0.00036287858,0.00010223027,0.008100449],"study_design_scores_gemma":[0.000155847,0.009445691,0.0045098686,0.000025802465,0.0000435708,0.00047765236,0.00006271049,0.0012728033,0.97994506,0.00011838351,0.003927411,0.000015261949],"about_ca_topic_score_codex":0.00063619844,"about_ca_topic_score_gemma":0.0006855008,"teacher_disagreement_score":0.0015852993,"about_ca_system_score_codex":0.00011671027,"about_ca_system_score_gemma":0.00011954408,"threshold_uncertainty_score":0.005303383},"labels":[],"label_agreement":null},{"id":"W1970926049","doi":"10.1016/j.bmcl.2009.04.108","title":"Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sulfur-Based Synthesis Techniques","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; 5-HT6 receptor; Identification (biology); Dementia; Schizophrenia (object-oriented programming); Pharmacology; Neuroscience; Disease; Stereochemistry; Psychology; Receptor; Internal medicine; Serotonin; Biochemistry; Psychiatry; Medicine; 5-HT receptor","score_opus":0.011076842229510771,"score_gpt":0.23749535329978538,"score_spread":0.2264185110702746,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970926049","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97334576,0.009175043,0.009074362,0.0003515624,0.00007708996,0.00020756845,0.0006667951,0.00027597655,0.006825918],"genre_scores_gemma":[0.9808029,0.004621685,0.0067324587,0.00018429659,0.000034009223,0.00010552836,0.001394322,0.000018382818,0.006106442],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993074,0.000012709102,0.0000053305444,0.000009353033,0.000020666836,0.00002118015],"domain_scores_gemma":[0.9999484,0.000007235978,0.000013762807,0.0000049699906,0.000009928749,0.000015777434],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019457737,0.00033822522,0.00029528915,0.00020191217,0.0001648803,0.00021447078,0.0005046259,0.0002333796,0.0016592123],"category_scores_gemma":[0.000146675,0.00012885725,0.00014138075,0.00017149026,0.00015732492,0.00018296036,0.00021967087,0.00054548716,0.00047617962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040008375,0.00016503959,0.00064339273,0.000160589,0.000020282558,0.0002915953,0.00008360298,0.0008387191,0.96754014,0.0009305575,0.00076964893,0.028156307],"study_design_scores_gemma":[0.000301267,0.004724414,0.005545692,0.00003511775,0.00009089049,0.0018267131,0.00006358809,0.0037839978,0.9517036,0.00023696334,0.031655595,0.000032163345],"about_ca_topic_score_codex":0.0005491127,"about_ca_topic_score_gemma":0.0027269037,"teacher_disagreement_score":0.0016592123,"about_ca_system_score_codex":0.00035269305,"about_ca_system_score_gemma":0.0002382033,"threshold_uncertainty_score":0.005550623},"labels":[],"label_agreement":null},{"id":"W1970939791","doi":"10.1016/j.bmcl.2011.05.013","title":"Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Lipophilicity; In vivo; Renin inhibitor; In vitro; Renin–angiotensin system; Pharmacology; Amide; 2-Pyridone; Stereochemistry; Ex vivo; Combinatorial chemistry; Biochemistry; Endocrinology","score_opus":0.07702256091935054,"score_gpt":0.23956728240243164,"score_spread":0.16254472148308108,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970939791","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92094964,0.03127271,0.036414403,0.0005603734,0.00025872054,0.00051810645,0.0006197168,0.0004029322,0.009003294],"genre_scores_gemma":[0.9413545,0.018889021,0.033977855,0.00034371708,0.00008633477,0.000171813,0.00051283813,0.0000364414,0.004627421],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999168,0.000019168503,0.000008787613,0.00001595416,0.000020758258,0.000018491904],"domain_scores_gemma":[0.999926,0.000013031388,0.00002228431,0.0000054529905,0.000012884802,0.000020418911],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003417872,0.0004287885,0.00037808908,0.0001692059,0.00016242062,0.00021777913,0.0003872749,0.00017270143,0.0013063162],"category_scores_gemma":[0.00020293781,0.00018318414,0.00022190607,0.00013224434,0.00016747124,0.0003392767,0.0001803271,0.00057860825,0.00029621006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014560777,0.0006228443,0.00060127425,0.00078172673,0.000054923163,0.00065248634,0.0002196761,0.004433823,0.90145284,0.0028196336,0.0010700821,0.085834704],"study_design_scores_gemma":[0.002580431,0.022163408,0.005908136,0.00018303275,0.0003373169,0.003118715,0.0001338846,0.018964434,0.87673146,0.00091956335,0.06882821,0.00013143923],"about_ca_topic_score_codex":0.00032986296,"about_ca_topic_score_gemma":0.0015926068,"teacher_disagreement_score":0.0013063162,"about_ca_system_score_codex":0.00019795907,"about_ca_system_score_gemma":0.0002829687,"threshold_uncertainty_score":0.0043700933},"labels":[],"label_agreement":null},{"id":"W1971357574","doi":"10.1016/s0960-894x(02)00987-3","title":"A facile synthesis of C2-symmetric 17β-estradiol dimers","year":2003,"lang":"it","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Saint-François d'Assise; Université du Québec à Trois-Rivières","funders":"","keywords":"Chemistry; Chemical synthesis; Combinatorial chemistry; Stereochemistry; In vitro; Biochemistry","score_opus":0.06561764248673992,"score_gpt":0.34003376668094026,"score_spread":0.27441612419420036,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971357574","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8948866,0.004004348,0.040279713,0.0009156858,0.00060594693,0.00029539183,0.001399316,0.0003726381,0.057240434],"genre_scores_gemma":[0.9667019,0.0018519644,0.011211959,0.00020814649,0.000040300583,0.00010682895,0.00048777033,0.000056357858,0.019334763],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998996,0.000015745927,0.000007152323,0.000024033268,0.000024304787,0.000029171335],"domain_scores_gemma":[0.9999633,0.000005508384,0.000005597792,0.000008043036,0.0000062173935,0.000011322451],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014611453,0.0002928578,0.00021660229,0.000108463515,0.0003195894,0.00016707537,0.00036739142,0.00025829216,0.0044724247],"category_scores_gemma":[0.00010199721,0.0001950637,0.00012700791,0.0001329472,0.00010338891,0.00023228672,0.0003287071,0.00050981453,0.0014800824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020387457,0.00013922012,0.00011796384,0.00023264739,0.000014586991,0.0003529195,0.00014290297,0.0011109598,0.96915686,0.0045564314,0.0018710501,0.022100547],"study_design_scores_gemma":[0.000045975547,0.0003267446,0.00020506734,0.000007808024,0.0000066826337,0.00025851864,0.00002973598,0.0008897276,0.97698057,0.00050770195,0.020725261,0.000016140613],"about_ca_topic_score_codex":0.00019780152,"about_ca_topic_score_gemma":0.0005204307,"teacher_disagreement_score":0.0044724247,"about_ca_system_score_codex":0.00014425602,"about_ca_system_score_gemma":0.00024863775,"threshold_uncertainty_score":0.014961779},"labels":[],"label_agreement":null},{"id":"W1971537665","doi":"10.1016/j.bmcl.2008.06.013","title":"Synthesis and cytotoxic activity of benzopyran-based platinum(II) complexes","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"College of the North Atlantic; Memorial University of Newfoundland; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Enantiomer; Stereochemistry; In vitro; Combinatorial chemistry; Benzopyran; Chemical synthesis; Platinum; Biological activity; Molecule; Molecular model; Docking (animal); Cytotoxicity; Quantitative structure–activity relationship; Organic chemistry; Biochemistry; Catalysis","score_opus":0.038511566844107524,"score_gpt":0.23759642232537106,"score_spread":0.19908485548126353,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971537665","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9806732,0.004982209,0.0049636653,0.00024276193,0.000087501794,0.00011805485,0.00046701395,0.00015275451,0.008312818],"genre_scores_gemma":[0.9926783,0.0014942314,0.0017606398,0.00003353829,0.000012612688,0.000030412019,0.00026334487,0.000019941152,0.0037069342],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999869,0.000027019008,0.000016887114,0.000020965106,0.0000417026,0.000024361174],"domain_scores_gemma":[0.9999243,0.000013364362,0.000020661852,0.000011642139,0.000016515694,0.000013508518],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016144571,0.00018217006,0.00023982265,0.00020459585,0.00019680636,0.00029143284,0.00045096272,0.00021043555,0.0014318029],"category_scores_gemma":[0.00029991072,0.00015897465,0.00010611249,0.00025914342,0.00013112805,0.00018402585,0.00020322962,0.0002622308,0.00030814676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003435514,0.00005863707,0.0001462042,0.00018609887,0.000017525364,0.00009341981,0.00005333327,0.00071895623,0.99154925,0.00059362786,0.00027577803,0.0059637087],"study_design_scores_gemma":[0.000027201868,0.0002353404,0.00036808164,0.0000042722063,0.000014024814,0.0000701877,0.0000057163365,0.00048701314,0.99611026,0.0000283235,0.0026451668,0.0000044527283],"about_ca_topic_score_codex":0.00070585846,"about_ca_topic_score_gemma":0.0010807913,"teacher_disagreement_score":0.0014318029,"about_ca_system_score_codex":0.0003984126,"about_ca_system_score_gemma":0.0001871034,"threshold_uncertainty_score":0.0047898293},"labels":[],"label_agreement":null},{"id":"W1971562588","doi":"10.1016/j.bmcl.2009.03.010","title":"Discovery of potent and selective DP1 receptor antagonists in the azaindole series","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Receptor; Pharmacology; Stereochemistry; Biochemistry; Biology","score_opus":0.004785617523555949,"score_gpt":0.2083990507083683,"score_spread":0.20361343318481237,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971562588","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9184206,0.027321778,0.028817121,0.0013460009,0.00035903096,0.00049086276,0.0012847428,0.0004657672,0.021494173],"genre_scores_gemma":[0.952819,0.02038288,0.012214274,0.0007651651,0.0001761191,0.00018553693,0.0012512801,0.00004792673,0.012157653],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989533,0.000019362862,0.0000064160076,0.000017361792,0.000026625841,0.000034880253],"domain_scores_gemma":[0.9999441,0.000010511056,0.00001199503,0.000003639573,0.000008288888,0.000021378824],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002789201,0.00043220015,0.0006426197,0.00030868984,0.00020192063,0.00037947408,0.00051671045,0.0002877882,0.0023497383],"category_scores_gemma":[0.00021637544,0.00021281226,0.00019111013,0.00018101739,0.00023068064,0.00037363335,0.00035170288,0.0007691387,0.00072226825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005872075,0.0001894957,0.00055253017,0.0003464744,0.000073216055,0.00055879966,0.00015926032,0.0017007577,0.9355632,0.0057516056,0.002434315,0.052083217],"study_design_scores_gemma":[0.0009248155,0.0077174925,0.0053664003,0.00008714507,0.00026228215,0.0026611248,0.00008698216,0.006160981,0.8914142,0.0022576791,0.08296295,0.00009803647],"about_ca_topic_score_codex":0.0004009366,"about_ca_topic_score_gemma":0.0016419565,"teacher_disagreement_score":0.0023497383,"about_ca_system_score_codex":0.00040220885,"about_ca_system_score_gemma":0.00021514625,"threshold_uncertainty_score":0.007860661},"labels":[],"label_agreement":null},{"id":"W1971586535","doi":"10.1016/j.bmcl.2008.10.116","title":"2,6,9-Trisubstituted purine derivatives as protein A mimetics for the treatment of autoimmune diseases","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Chemistry; Purine; Purine metabolism; Purine analogue; Antibody; Biochemistry; Stereochemistry; Enzyme; Immunology; Medicine","score_opus":0.03219205191669177,"score_gpt":0.29380919813282225,"score_spread":0.26161714621613047,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971586535","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9656583,0.02361653,0.003061883,0.00028573629,0.00018377001,0.0000725195,0.00025815377,0.00019943518,0.006663708],"genre_scores_gemma":[0.98680556,0.008123369,0.0022818365,0.00013261529,0.00006647571,0.0000442627,0.00017330836,0.000019130624,0.00235344],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993443,0.000025840613,0.000005439834,0.000008252652,0.0000116521205,0.000014344687],"domain_scores_gemma":[0.99996066,0.0000092889895,0.000009994375,0.0000035459686,0.0000035516882,0.000012863027],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019325464,0.00021851044,0.00022529623,0.0002461204,0.00014991328,0.00017121217,0.0003035893,0.00033063718,0.0011686973],"category_scores_gemma":[0.000110268185,0.00012724914,0.00011882875,0.00018063652,0.00014038946,0.00019297143,0.00012564313,0.0003672321,0.00028616682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014345986,0.00019407211,0.00025193454,0.00020712349,0.000028345234,0.0005975525,0.00007339501,0.0013612591,0.9586657,0.0015051271,0.00066629285,0.035014592],"study_design_scores_gemma":[0.0005207229,0.0051341774,0.0032889114,0.000037207876,0.00009659939,0.0016789386,0.00003529853,0.003489348,0.95929235,0.00042785282,0.025953246,0.000045225337],"about_ca_topic_score_codex":0.00021219511,"about_ca_topic_score_gemma":0.00050362473,"teacher_disagreement_score":0.0011686973,"about_ca_system_score_codex":0.00018563842,"about_ca_system_score_gemma":0.00012795973,"threshold_uncertainty_score":0.003909707},"labels":[],"label_agreement":null},{"id":"W1971784984","doi":"10.1016/j.bmcl.2013.04.043","title":"Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: In vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Reverse transcriptase; Potency; Bioavailability; In vivo; Pharmacology; Pharmacokinetics; Enzyme inhibitor; Enzyme; CYP3A4; Efflux; Reverse-transcriptase inhibitor; Biochemistry; In vitro; Cytochrome P450; Biology; RNA","score_opus":0.007814370448937416,"score_gpt":0.1949019201887962,"score_spread":0.1870875497398588,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971784984","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9779515,0.011776601,0.005675269,0.00027624465,0.0000578995,0.00027817904,0.0009450387,0.00011853882,0.0029207317],"genre_scores_gemma":[0.9754995,0.012440724,0.0059101465,0.00016384001,0.000032561096,0.00014358657,0.0020568925,0.000035554473,0.0037171387],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988866,0.000022014796,0.000008405011,0.000018294404,0.000029339782,0.000033232634],"domain_scores_gemma":[0.9999292,0.000013119491,0.000017149792,0.0000058003034,0.000012851892,0.000021824704],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024024579,0.0005666812,0.00060456473,0.00035385112,0.00017577574,0.00040503536,0.00038608164,0.00027969744,0.0013682356],"category_scores_gemma":[0.00019170238,0.0002666901,0.00025245303,0.00027426347,0.00019342071,0.00026324132,0.00017843729,0.00076939195,0.00035322082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008557092,0.0006551369,0.0004204704,0.00021015994,0.000043907676,0.0002351705,0.000058416717,0.0025082703,0.97771966,0.00033852734,0.0004280156,0.016526537],"study_design_scores_gemma":[0.0009171191,0.0104087265,0.0040855287,0.000052471976,0.00023914149,0.0010453293,0.00005398892,0.0037731053,0.96715117,0.00013046598,0.01209956,0.000043319593],"about_ca_topic_score_codex":0.00073907233,"about_ca_topic_score_gemma":0.0034098742,"teacher_disagreement_score":0.0013682356,"about_ca_system_score_codex":0.00035009917,"about_ca_system_score_gemma":0.00035473754,"threshold_uncertainty_score":0.00457716},"labels":[],"label_agreement":null},{"id":"W1971942652","doi":"10.1016/s0960-894x(01)00150-0","title":"The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Respiratory viral infections research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Virus; In vitro; Structure–activity relationship; In vivo; Chemical synthesis; Mononegavirales; Respiratory system; Pneumovirinae; Stereochemistry; Ex vivo; Enzyme inhibitor; Combinatorial chemistry; Biochemistry; Virology; Paramyxoviridae; Viral disease; Biology","score_opus":0.01625147853194079,"score_gpt":0.287337501360238,"score_spread":0.2710860228282972,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971942652","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9463141,0.028574675,0.008438423,0.0019268118,0.00039771263,0.00018306413,0.00070119457,0.00025280178,0.013211242],"genre_scores_gemma":[0.9685875,0.01715902,0.0032763185,0.0004610092,0.00010874718,0.000044551336,0.0008384279,0.000031857748,0.009492528],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999198,0.000010051028,0.0000043176938,0.000011344212,0.000018323208,0.000036136338],"domain_scores_gemma":[0.99995697,0.000008592944,0.000007049904,0.0000036457825,0.00000873171,0.00001511602],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029684557,0.00036960866,0.0003462835,0.00039762264,0.00018989043,0.00047516465,0.00043556583,0.0005054664,0.00081076],"category_scores_gemma":[0.00021483385,0.0002469584,0.0002655719,0.00020103464,0.00026199492,0.00027500262,0.00021183789,0.00081517606,0.00049888314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007755734,0.00018768001,0.0006900567,0.00023420925,0.0000364153,0.0007414964,0.000081328675,0.001449926,0.91935915,0.0021918959,0.0019241255,0.07232816],"study_design_scores_gemma":[0.00037823836,0.002022266,0.0041041886,0.00003196104,0.000091020665,0.0017682239,0.000038969374,0.00319799,0.9529975,0.00048205705,0.03485201,0.000035590063],"about_ca_topic_score_codex":0.0009173803,"about_ca_topic_score_gemma":0.001359942,"teacher_disagreement_score":0.0009173803,"about_ca_system_score_codex":0.00045706207,"about_ca_system_score_gemma":0.0003250479,"threshold_uncertainty_score":0.0033162236},"labels":[],"label_agreement":null},{"id":"W1971971142","doi":"10.1016/j.bmcl.2011.04.059","title":"From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Indole test; NS5B; Benzimidazole; ADME; Allosteric regulation; Stereochemistry; Carboxamide; Potency; In vivo; Drug discovery; Biochemistry; In vitro; Enzyme; Biology","score_opus":0.01833424958890368,"score_gpt":0.22989273351582445,"score_spread":0.21155848392692078,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1971971142","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9097062,0.03715133,0.013192504,0.0013425058,0.00037009822,0.00043311474,0.0011044109,0.0007567073,0.035943184],"genre_scores_gemma":[0.9759961,0.013041556,0.0030068194,0.00026298864,0.00004739119,0.000061297236,0.0007747659,0.000027790531,0.006781451],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999621,0.00000534653,0.0000028298807,0.0000054186257,0.000007955693,0.00001629935],"domain_scores_gemma":[0.99997866,0.00000519508,0.000004436588,0.0000026216817,0.000003020445,0.000006131104],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012655638,0.0003470646,0.00019614448,0.0002118385,0.00015193333,0.00027788707,0.0003461391,0.0002087081,0.0024573058],"category_scores_gemma":[0.000146722,0.00020689164,0.00023590717,0.00017782277,0.00021626303,0.0002430386,0.00020946287,0.00044038834,0.000597355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010595531,0.00025743383,0.00041117004,0.0005028559,0.000023029139,0.00071801676,0.00022224335,0.0037578484,0.9075818,0.0031306953,0.003285874,0.079049535],"study_design_scores_gemma":[0.00089142524,0.0058211363,0.0058645597,0.00010787589,0.00010281423,0.0015879981,0.00009036917,0.006136111,0.89551926,0.0015656635,0.082241505,0.000071366776],"about_ca_topic_score_codex":0.0016182616,"about_ca_topic_score_gemma":0.004714685,"teacher_disagreement_score":0.0024573058,"about_ca_system_score_codex":0.00045430035,"about_ca_system_score_gemma":0.0002561727,"threshold_uncertainty_score":0.008220434},"labels":[],"label_agreement":null},{"id":"W1972336916","doi":"10.1016/j.bmcl.2008.01.009","title":"Novel highly potent μ-opioid receptor antagonist based on endomorphin-2 structure","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Pharmacology; Opioid receptor; Antagonist; Opioid; Receptor; In vivo; Stereochemistry; Biochemistry; Biology","score_opus":0.022171861007339685,"score_gpt":0.2153477348423023,"score_spread":0.1931758738349626,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972336916","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.958333,0.006580457,0.01962607,0.0006285568,0.00034043685,0.0002539386,0.00069815974,0.0003920075,0.013147378],"genre_scores_gemma":[0.9747185,0.0032675143,0.010024137,0.0005073284,0.00007328735,0.000085882115,0.0007994126,0.000028715236,0.010495257],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996626,0.000004242285,0.0000016951227,0.000008075864,0.000006379664,0.0000133557105],"domain_scores_gemma":[0.9999883,0.000001192694,0.0000023623027,0.0000010187234,0.0000019203478,0.00000523679],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000066447945,0.00036173884,0.00041872024,0.00013472993,0.00019092891,0.00022045623,0.00043748826,0.00024176191,0.0014367555],"category_scores_gemma":[0.000044520388,0.00014366601,0.00014240116,0.00008645495,0.00010166501,0.00021043053,0.00018799663,0.0004675495,0.00046271668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026460935,0.00009013223,0.00009812794,0.0000893246,0.000014967483,0.00037830012,0.000025594174,0.00022135247,0.98960704,0.0005287977,0.0004884368,0.008193281],"study_design_scores_gemma":[0.0004221077,0.003858215,0.0029640417,0.000018590974,0.00009007295,0.002540697,0.000038174654,0.0034280887,0.9558345,0.00039188267,0.030361338,0.000052244297],"about_ca_topic_score_codex":0.0002898357,"about_ca_topic_score_gemma":0.00067736884,"teacher_disagreement_score":0.0014367555,"about_ca_system_score_codex":0.00014784749,"about_ca_system_score_gemma":0.00017768431,"threshold_uncertainty_score":0.004806459},"labels":[],"label_agreement":null},{"id":"W1972966873","doi":"10.1016/s0960-894x(01)00419-x","title":"The discovery of anthranilic acid-Based MMP inhibitors. Part 2: SAR of the 5-position and P11 groups","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Anthranilic acid; Matrix metalloproteinase; Enzyme inhibitor; Hydroxamic acid; Chemical synthesis; Pharmacology; Stereochemistry; Enzyme; Biochemistry; In vitro","score_opus":0.005083510434417063,"score_gpt":0.19679892062876722,"score_spread":0.19171541019435015,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1972966873","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7891136,0.15115096,0.03234276,0.0030281343,0.0006364043,0.00040353852,0.0010042752,0.0004458663,0.02187447],"genre_scores_gemma":[0.87325454,0.09844608,0.011187243,0.00065430714,0.00031940488,0.00010581121,0.0009805036,0.000027793081,0.015024305],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999436,0.0000113086535,0.000003976565,0.0000071176482,0.000018712972,0.000015300067],"domain_scores_gemma":[0.999946,0.000014732555,0.000011521622,0.000004129482,0.0000069690823,0.000016661375],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026077477,0.00044446404,0.00027718427,0.0002415656,0.00013584876,0.00037640997,0.00026901145,0.00027990152,0.0014621761],"category_scores_gemma":[0.00022500621,0.00022701199,0.0002879556,0.0001620523,0.0002627148,0.0004098854,0.0001701574,0.0007269862,0.00064014125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010482057,0.00037081563,0.00037168126,0.0007230602,0.00004381813,0.0007212506,0.00012357284,0.0040605403,0.87970173,0.0047604563,0.0029412338,0.10513369],"study_design_scores_gemma":[0.0005801982,0.0034369526,0.0035406733,0.00008642912,0.000095469535,0.0015039941,0.000037816106,0.003867947,0.9025576,0.001686176,0.08255946,0.000047244397],"about_ca_topic_score_codex":0.0002978335,"about_ca_topic_score_gemma":0.000488806,"teacher_disagreement_score":0.0014621761,"about_ca_system_score_codex":0.0003358153,"about_ca_system_score_gemma":0.00021220601,"threshold_uncertainty_score":0.0048913956},"labels":[],"label_agreement":null},{"id":"W1973175883","doi":"10.1016/j.bmcl.2010.01.053","title":"Design, synthesis and biological evaluation of estradiol–chlorambucil hybrids as anticancer agents","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Chlorambucil; Chemistry; Estrone; In vitro; Steroid; Anticancer drug; Biological activity; Hybrid; Stereochemistry; Drug; Pharmacology; Hormone; Cancer research; Biochemistry; Chemotherapy; Internal medicine; Biology","score_opus":0.022037680254210056,"score_gpt":0.26946997667136474,"score_spread":0.2474322964171547,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973175883","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.989638,0.0023556754,0.0049207234,0.00012449933,0.000028649814,0.00011773767,0.00022916433,0.00007962123,0.0025059453],"genre_scores_gemma":[0.993725,0.0007347613,0.0038459124,0.000042122723,0.000006735999,0.00005703152,0.00020812695,0.000015568727,0.0013648206],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990106,0.000022652855,0.000009536021,0.000018718707,0.00002402134,0.000023893896],"domain_scores_gemma":[0.9999213,0.000019099742,0.000020101023,0.000009308355,0.000015359403,0.0000147418195],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002129448,0.00022018775,0.00021073932,0.00025766864,0.0002078488,0.00033761794,0.0002921102,0.0002854793,0.0009505914],"category_scores_gemma":[0.00023016302,0.00016654746,0.00018796565,0.0001548865,0.00016456867,0.00017689723,0.000170464,0.00028834242,0.00023092116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000266576,0.000065052045,0.00012421672,0.00005638533,0.000015859485,0.00006936599,0.000036848287,0.00071357744,0.9939016,0.00030403986,0.000058773825,0.004387704],"study_design_scores_gemma":[0.000036944697,0.00040874325,0.00034161046,0.0000029637738,0.000020573805,0.000070604765,0.000010445834,0.0004026959,0.99623317,0.00002250558,0.0024445516,0.0000052285113],"about_ca_topic_score_codex":0.00038945608,"about_ca_topic_score_gemma":0.0005282278,"teacher_disagreement_score":0.0009505914,"about_ca_system_score_codex":0.0003350076,"about_ca_system_score_gemma":0.0001344881,"threshold_uncertainty_score":0.0031800866},"labels":[],"label_agreement":null},{"id":"W1973762930","doi":"10.1016/j.bmcl.2006.09.083","title":"Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph","funders":"National Heart, Lung, and Blood Institute","keywords":"Chemistry; Pulmonary surfactant; Surface tension; Stereochemistry; Chemical synthesis; Bubble; Combinatorial chemistry; Biophysics; In vitro; Biochemistry; Thermodynamics","score_opus":0.009141442176025538,"score_gpt":0.23400044662683595,"score_spread":0.22485900445081042,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973762930","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99074215,0.0013754625,0.006097722,0.00014843722,0.000023611492,0.000019607236,0.00017038449,0.000043875865,0.0013787161],"genre_scores_gemma":[0.99292725,0.0010265394,0.0031570976,0.000046025212,0.0000075145845,0.000014909347,0.000260023,0.00002263664,0.002538055],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999455,0.000009447039,0.0000058747573,0.000008722148,0.00001230704,0.00001814516],"domain_scores_gemma":[0.99993944,0.00001539906,0.000014790473,0.0000087224025,0.000010920715,0.000010639939],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015235403,0.00022147065,0.00010776002,0.00013491735,0.00008375888,0.00024668474,0.00017431431,0.00024434717,0.00091368775],"category_scores_gemma":[0.0001962689,0.000090011075,0.00014448316,0.0001489701,0.00013420549,0.00025889868,0.0001925913,0.00031798866,0.00026235386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000097122575,0.000012213419,0.00006016433,0.000027452821,0.0000022380593,0.00003273278,0.00001627457,0.00012558508,0.99744713,0.00022364315,0.000022351765,0.0019330621],"study_design_scores_gemma":[0.0000033147162,0.000034396162,0.00007878167,9.4725345e-7,0.0000028409108,0.000016564574,0.0000038870517,0.00016244907,0.9992101,0.000018457791,0.0004673004,8.320676e-7],"about_ca_topic_score_codex":0.0003199354,"about_ca_topic_score_gemma":0.0005361072,"teacher_disagreement_score":0.00091368775,"about_ca_system_score_codex":0.00028989042,"about_ca_system_score_gemma":0.00018610203,"threshold_uncertainty_score":0.0030565858},"labels":[],"label_agreement":null},{"id":"W1973885230","doi":"10.1016/j.bmcl.2010.06.130","title":"Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":68,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Lycorine; Amaryllidaceae Alkaloids; Chemistry; Amaryllidaceae; Pharmacophore; Acetylcholinesterase; Alkaloid; Stereochemistry; Silylation; Enzyme; Biochemistry; Biology; Botany","score_opus":0.014611067358741294,"score_gpt":0.250160197396493,"score_spread":0.23554913003775169,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973885230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9917514,0.005297583,0.0004281518,0.0000646591,0.000018468521,0.00004085344,0.00022699244,0.000022809558,0.0021492473],"genre_scores_gemma":[0.9949215,0.0029460953,0.00043856454,0.00004553314,0.00001946638,0.000017956238,0.00038477953,0.0000064376986,0.0012197107],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986196,0.00004338389,0.000016918266,0.000016629563,0.000030866464,0.000030178715],"domain_scores_gemma":[0.99976915,0.00007650231,0.000044217486,0.000019453217,0.000051431216,0.000039219118],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025602742,0.0002898086,0.000391075,0.00038751046,0.00016744855,0.00018486845,0.00036553634,0.00025796608,0.0014193252],"category_scores_gemma":[0.00035537916,0.00016496539,0.000343167,0.00028012658,0.00020433051,0.00020696248,0.0001937938,0.0004351935,0.00027083475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015468921,0.0003146437,0.0008080395,0.00020256403,0.000051392053,0.00015670247,0.00009623723,0.00061822037,0.986809,0.00015727528,0.00010926594,0.009129659],"study_design_scores_gemma":[0.0005350622,0.01783281,0.019872729,0.000047044832,0.0002513823,0.0005259376,0.00009252812,0.0025506779,0.95289844,0.00009721189,0.0052642566,0.000031968782],"about_ca_topic_score_codex":0.0013331922,"about_ca_topic_score_gemma":0.0023236598,"teacher_disagreement_score":0.0014193252,"about_ca_system_score_codex":0.0001592564,"about_ca_system_score_gemma":0.00013993037,"threshold_uncertainty_score":0.0047481656},"labels":[],"label_agreement":null},{"id":"W1974047811","doi":"10.1016/j.bmcl.2013.01.057","title":"Synthesis and growth inhibition activity of fluorinated derivatives of tamoxifen","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Saint-François d'Assise; PROTEO; Université Laval","funders":"","keywords":"Tamoxifen; Chemistry; Growth inhibition; In vitro; Isomerization; Stereochemistry; Cell culture; Cell growth; Pharmacology; Biochemistry; Internal medicine; Cancer; Catalysis; Breast cancer","score_opus":0.004289818339558488,"score_gpt":0.1936892857991535,"score_spread":0.18939946745959502,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974047811","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98345965,0.004095197,0.004603864,0.00021818378,0.00006904781,0.000041291798,0.00074012706,0.00008433599,0.0066882414],"genre_scores_gemma":[0.9930211,0.0015269784,0.001314767,0.000039999642,0.000014167552,0.000011713724,0.00047996026,0.000012900811,0.0035784328],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993575,0.000008963839,0.000006649382,0.000010089374,0.000011936288,0.000026590682],"domain_scores_gemma":[0.99995005,0.000008457294,0.000015457977,0.000006973977,0.0000079682395,0.000011087256],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011261618,0.0002353002,0.00013396742,0.00017612369,0.0001356872,0.00011999096,0.00034023874,0.00021895341,0.0018527418],"category_scores_gemma":[0.0001183424,0.000087658846,0.00017252137,0.00016070358,0.00011866864,0.00015108228,0.0001129836,0.00025433893,0.00029761466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00051384,0.000054943233,0.00015550356,0.000080093414,0.00001108061,0.00033790842,0.000052790343,0.00047062314,0.99237305,0.0005818244,0.0001704124,0.00519779],"study_design_scores_gemma":[0.00003073814,0.0006460524,0.00073134166,0.0000058808064,0.000015909372,0.00017737519,0.000012534382,0.00026496107,0.9928455,0.000045185636,0.0052176462,0.0000068902064],"about_ca_topic_score_codex":0.000892077,"about_ca_topic_score_gemma":0.0012016412,"teacher_disagreement_score":0.0018527418,"about_ca_system_score_codex":0.00022947455,"about_ca_system_score_gemma":0.00018270129,"threshold_uncertainty_score":0.0061980486},"labels":[],"label_agreement":null},{"id":"W1974194495","doi":"10.1016/j.bmcl.2014.10.084","title":"One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Inversago Pharma (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke","keywords":"Chemistry; Polyunsaturated fatty acid; Lipase; Fatty acid; Organic chemistry; Biochemistry; Chemical synthesis; Enzyme; In vitro","score_opus":0.009680180306125353,"score_gpt":0.19739360028962633,"score_spread":0.18771341998350097,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974194495","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9215762,0.007445399,0.03670162,0.0004083107,0.00032719446,0.00026046816,0.001239736,0.00032705517,0.03171399],"genre_scores_gemma":[0.976239,0.004173196,0.011891725,0.00015501866,0.000040262632,0.000112213835,0.00038918908,0.00003756786,0.00696187],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999151,0.000011333951,0.000008285156,0.0000144517035,0.000013802794,0.00003695052],"domain_scores_gemma":[0.9999337,0.000010386161,0.00001775148,0.0000059558815,0.000010657538,0.000021599026],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021169009,0.0006683612,0.00027968572,0.00023702296,0.00019605136,0.00019017163,0.00036311848,0.0004016089,0.0020866692],"category_scores_gemma":[0.00012488596,0.000153758,0.0003351734,0.0002887033,0.0001543388,0.00042495248,0.00038933504,0.00048377962,0.0008067218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003857595,0.00016506345,0.00021873009,0.00043498073,0.0000410783,0.0009541973,0.00015063408,0.001152259,0.96599644,0.0020219004,0.00057787466,0.027901027],"study_design_scores_gemma":[0.00007135734,0.0011147289,0.0007122972,0.000024570996,0.000048430178,0.0005441173,0.000040494655,0.00085997814,0.98291034,0.0004812635,0.01316101,0.000031392665],"about_ca_topic_score_codex":0.0002290354,"about_ca_topic_score_gemma":0.000534475,"teacher_disagreement_score":0.0020866692,"about_ca_system_score_codex":0.00019739478,"about_ca_system_score_gemma":0.00030022283,"threshold_uncertainty_score":0.006980598},"labels":[],"label_agreement":null},{"id":"W1974218564","doi":"10.1016/j.bmcl.2009.10.040","title":"N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Liver physiology and pathology","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; In vitro; Receptor tyrosine kinase; Tyrosine kinase; In vivo; Stereochemistry; IC50; Kinase; Enzyme; Carboxamide; Pharmacokinetics; Molecular model; Pharmacology; Receptor; Biochemistry; Biology","score_opus":0.015033068129425103,"score_gpt":0.23482040664490492,"score_spread":0.21978733851547982,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974218564","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.88897574,0.046533335,0.028019788,0.001204265,0.0007231912,0.00044978602,0.0014830411,0.0014811725,0.031129738],"genre_scores_gemma":[0.97204053,0.011434941,0.006654433,0.00033882822,0.00010577108,0.0002304002,0.00056535203,0.000036937545,0.008592817],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988925,0.000019769323,0.000005801809,0.00002071511,0.000020525069,0.000043926342],"domain_scores_gemma":[0.9999528,0.0000056738922,0.000014091785,0.0000029347862,0.000007110597,0.000017400913],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028915258,0.0006121382,0.0004436877,0.00034133685,0.00020524493,0.00023511093,0.00084637577,0.00032266037,0.0019989633],"category_scores_gemma":[0.00013766396,0.0001685407,0.00018939009,0.00021763655,0.00022606117,0.0003042598,0.0002969534,0.00058072206,0.0006478748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015403581,0.0005113783,0.00047107405,0.00075019593,0.000054816355,0.0008913022,0.00025768531,0.0024238585,0.9047522,0.0047912854,0.005140517,0.07841539],"study_design_scores_gemma":[0.0029403553,0.01201761,0.010163409,0.00014984881,0.00025577462,0.005137305,0.0001727762,0.011078328,0.8279544,0.00089429127,0.12906589,0.00016999814],"about_ca_topic_score_codex":0.000726696,"about_ca_topic_score_gemma":0.0021522534,"teacher_disagreement_score":0.0019989633,"about_ca_system_score_codex":0.00051119213,"about_ca_system_score_gemma":0.00029370727,"threshold_uncertainty_score":0.0066871643},"labels":[],"label_agreement":null},{"id":"W1974281114","doi":"10.1016/j.bmcl.2013.05.042","title":"Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Depsipeptide; Nonribosomal peptide; Polyketide; Streptomyces; Biosynthesis; Chemistry; Stereochemistry; Streptomycetaceae; Polyketide synthase; Peptide; Actinomycetales; Combinatorial chemistry; Biochemistry; Gene; Biology; Bacteria; Genetics","score_opus":0.009067988051577032,"score_gpt":0.20817626224491598,"score_spread":0.19910827419333896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974281114","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98945427,0.0034537746,0.0017801506,0.00007365406,0.000043459626,0.000059244034,0.0016529129,0.000048828548,0.0034336688],"genre_scores_gemma":[0.9904214,0.001640951,0.0034541728,0.000041241645,0.000017150005,0.000022559107,0.0027469243,0.000015351818,0.0016402173],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991786,0.000012857239,0.000016091026,0.000015405763,0.000015934866,0.0000217497],"domain_scores_gemma":[0.9999193,0.000009522454,0.000021616312,0.000008251756,0.0000093066765,0.00003204045],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009371784,0.0005583123,0.00026323632,0.000337914,0.00012188915,0.00041108145,0.00019396498,0.00018483179,0.0007579546],"category_scores_gemma":[0.0001219995,0.00013184948,0.00023250919,0.00026911046,0.00014980297,0.00020806295,0.00020914276,0.00035619014,0.0004557758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00050634524,0.000047907397,0.0007014492,0.0001375935,0.000014943547,0.0006741709,0.000072576964,0.00082769146,0.98582864,0.00028276895,0.00009827158,0.010807606],"study_design_scores_gemma":[0.00006140929,0.002156324,0.011385364,0.00004052687,0.00010279347,0.00077235885,0.00019029438,0.0010273069,0.97529465,0.00017390169,0.008766378,0.000028714105],"about_ca_topic_score_codex":0.0008815553,"about_ca_topic_score_gemma":0.0013857669,"teacher_disagreement_score":0.0008815553,"about_ca_system_score_codex":0.00022402451,"about_ca_system_score_gemma":0.0003679261,"threshold_uncertainty_score":0.0025356412},"labels":[],"label_agreement":null},{"id":"W1974311863","doi":"10.1016/j.bmcl.2006.10.055","title":"In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Metabolite; In vitro; Diastereomer; Antagonist; Glucuronide; Microsome; Chemical synthesis; Stereochemistry; Ketone; Microsoma; Biochemistry; Pharmacology; Receptor; Organic chemistry","score_opus":0.003784073637131375,"score_gpt":0.2008327492221131,"score_spread":0.19704867558498174,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974311863","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98398626,0.0029400794,0.006189966,0.00013300082,0.00007500685,0.00009454089,0.0012097217,0.00010066464,0.0052707647],"genre_scores_gemma":[0.99137104,0.0013743221,0.0031418868,0.000031109186,0.000014686757,0.000034353092,0.0006611954,0.000027336508,0.003344167],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998223,0.000043987326,0.000020723879,0.000020418098,0.000037420705,0.00005514238],"domain_scores_gemma":[0.9999137,0.000015883,0.00002171454,0.000015716414,0.000013723012,0.000019279378],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020269898,0.0004272191,0.00033329654,0.00023105108,0.0002152355,0.000224696,0.0002790111,0.00024107553,0.0020850105],"category_scores_gemma":[0.0002608643,0.00017680447,0.00040936077,0.00031285195,0.00014971786,0.00026219682,0.00023016873,0.00038228754,0.0008859514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006608652,0.0001984265,0.00020753572,0.00012543506,0.00002702431,0.00026241827,0.00006225976,0.0011029999,0.98881674,0.00045408064,0.00018064938,0.007901673],"study_design_scores_gemma":[0.000021963628,0.000455072,0.00023437123,0.0000026069908,0.0000142574,0.00007127728,0.000010068733,0.000207968,0.99715185,0.000034583998,0.0017910267,0.0000048668503],"about_ca_topic_score_codex":0.00082820543,"about_ca_topic_score_gemma":0.0015676492,"teacher_disagreement_score":0.0020850105,"about_ca_system_score_codex":0.0002910752,"about_ca_system_score_gemma":0.00039041493,"threshold_uncertainty_score":0.006974995},"labels":[],"label_agreement":null},{"id":"W1974626772","doi":"10.1016/j.bmcl.2004.05.049","title":"Lysine sulfonamides as novel HIV-protease inhibitors: Nε-disubstituted ureas","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Micropharma (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Sulfonamide; Lysine; Enzyme inhibitor; Protease; Human immunodeficiency virus (HIV); Protease inhibitor (pharmacology); Chemical synthesis; Enzyme; Biochemistry; Stereochemistry; Combinatorial chemistry; In vitro; Pharmacology; Virology; Amino acid; Antiretroviral therapy; Viral load","score_opus":0.009638792407571444,"score_gpt":0.2314912214735235,"score_spread":0.22185242906595204,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974626772","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95376474,0.022320293,0.008131052,0.0003836958,0.0003228498,0.00013251133,0.00018441168,0.00024976302,0.014510554],"genre_scores_gemma":[0.9826462,0.009579741,0.004046905,0.00019248085,0.000068959656,0.00005295147,0.000115551025,0.00001796741,0.003279219],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999044,0.000026773949,0.000008019922,0.0000117230375,0.000019754432,0.000029373447],"domain_scores_gemma":[0.9999454,0.000010499538,0.000012083142,0.00000487224,0.00000955661,0.000017600596],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033492967,0.0003500426,0.0003210629,0.00017048887,0.00015356722,0.00022307217,0.00048576106,0.00029194733,0.0009294062],"category_scores_gemma":[0.00020526313,0.00014580805,0.00016922686,0.0001255016,0.00021752244,0.00039635936,0.00022730004,0.00040793055,0.00028481134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012815743,0.0002995434,0.000418102,0.00043807397,0.000035947727,0.0008117453,0.00023458885,0.0024703566,0.91762847,0.0074984836,0.0012272042,0.06765585],"study_design_scores_gemma":[0.00036908363,0.006776689,0.0014384788,0.000054901364,0.00008989953,0.0011411081,0.00006761134,0.0045487103,0.95561683,0.00066514045,0.029187651,0.00004398082],"about_ca_topic_score_codex":0.00053979777,"about_ca_topic_score_gemma":0.001363861,"teacher_disagreement_score":0.0009294062,"about_ca_system_score_codex":0.0003854987,"about_ca_system_score_gemma":0.00024246715,"threshold_uncertainty_score":0.0031092167},"labels":[],"label_agreement":null},{"id":"W1974914594","doi":"10.1016/j.bmcl.2011.05.131","title":"Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n= 3′ or 4′) against Plasmodium falciparum in in vitro models","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Metropolitan University; Acadia University","funders":"Acadia University","keywords":"Plasmodium falciparum; Oxazole; Chemistry; In vitro; Cytotoxicity; Quinoline; Chemical synthesis; Potency; Stereochemistry; Biological activity; Combinatorial chemistry; Biochemistry; Malaria; Organic chemistry; Biology; Immunology","score_opus":0.049898082080549154,"score_gpt":0.25564936546713257,"score_spread":0.2057512833865834,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974914594","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9770049,0.0074110227,0.005508878,0.000167351,0.0000890673,0.00017777404,0.0015339821,0.00017705886,0.007929921],"genre_scores_gemma":[0.9870761,0.0029789917,0.0038761504,0.00006313491,0.00002352529,0.000081962986,0.0013292487,0.000015629237,0.004555159],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999256,0.000018581306,0.000008771213,0.000010849032,0.000013132463,0.000023036413],"domain_scores_gemma":[0.99993265,0.000014222393,0.000018502376,0.000007531991,0.000011680036,0.000015465757],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015919475,0.00035533225,0.00024570426,0.00018611713,0.00015163489,0.000095748226,0.0003450742,0.00017500728,0.0016622285],"category_scores_gemma":[0.00011289357,0.00016348247,0.00020618073,0.00012167837,0.0001190917,0.00014206847,0.000108444685,0.00021651742,0.000433517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00052962446,0.00008207987,0.00012110367,0.00020384887,0.000010404063,0.000120401215,0.00002852485,0.00044826185,0.9918624,0.00015520063,0.00020460847,0.006233595],"study_design_scores_gemma":[0.000088716646,0.0013482743,0.0017629509,0.000010001174,0.000022313987,0.0001536227,0.000011332555,0.00039553412,0.99206454,0.00002596003,0.004107922,0.000008802956],"about_ca_topic_score_codex":0.0011348024,"about_ca_topic_score_gemma":0.002048314,"teacher_disagreement_score":0.0016622285,"about_ca_system_score_codex":0.00020597795,"about_ca_system_score_gemma":0.00023867389,"threshold_uncertainty_score":0.005560696},"labels":[],"label_agreement":null},{"id":"W1974926123","doi":"10.1016/j.bmcl.2015.04.008","title":"Discovery of novel small-molecule antagonists for GluK2","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Glutamate receptor; Receptor; NMDA receptor; Kainate receptor; Neurotransmitter receptor; Docking (animal); Neurotransmitter; Ionotropic effect; Binding site; Small molecule; Pharmacology; Stereochemistry; Neuroscience; Biophysics; Biochemistry; AMPA receptor; Biology","score_opus":0.02898435876292921,"score_gpt":0.25142506348220894,"score_spread":0.22244070471927974,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974926123","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9257069,0.025714751,0.027472787,0.0024425413,0.00061422994,0.0006334207,0.0013995535,0.00077040587,0.015245342],"genre_scores_gemma":[0.953141,0.016980097,0.013064743,0.0010486564,0.00011621375,0.00024720703,0.001514711,0.000054959393,0.013832428],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999151,0.000010234568,0.0000067819287,0.000014852745,0.000022042059,0.00003089794],"domain_scores_gemma":[0.9999515,0.000008429308,0.000010606543,0.000003848574,0.000007634625,0.000018057328],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028132883,0.0006202222,0.0005854364,0.00027694576,0.00021872077,0.00072386075,0.00055479654,0.00047799095,0.0021606681],"category_scores_gemma":[0.00022733037,0.00031973812,0.00033043677,0.00015643785,0.00021261026,0.0003577856,0.0002748548,0.0011266866,0.0007842215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012433426,0.0002811446,0.00048209968,0.00024769787,0.000110546214,0.00051919156,0.000053669057,0.00095840043,0.9460013,0.0032434284,0.0025518814,0.04430725],"study_design_scores_gemma":[0.002106574,0.004495278,0.0029741386,0.00006333566,0.0002924224,0.0025074475,0.000080240956,0.006924107,0.91279066,0.0013335764,0.0663566,0.000075641525],"about_ca_topic_score_codex":0.00030121452,"about_ca_topic_score_gemma":0.001153904,"teacher_disagreement_score":0.0021606681,"about_ca_system_score_codex":0.0005407154,"about_ca_system_score_gemma":0.00031819547,"threshold_uncertainty_score":0.007228136},"labels":[],"label_agreement":null},{"id":"W1975090633","doi":"10.1016/j.bmcl.2010.02.060","title":"Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"University of Guelph","keywords":"Chemistry; DNA gyrase; Escherichia coli; Quercetin; In vitro; Stereochemistry; Antibacterial agent; Microbiology; Combinatorial chemistry; Antibiotics; Biochemistry; Biology; Gene","score_opus":0.1576320448530112,"score_gpt":0.3900674770453906,"score_spread":0.2324354321923794,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975090633","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9852651,0.0033082722,0.007935028,0.00017056319,0.00004101668,0.00030670268,0.00036437807,0.00006900873,0.0025399595],"genre_scores_gemma":[0.98511606,0.0028379443,0.009447589,0.00009174429,0.000013682738,0.00007442196,0.00054886274,0.000013452583,0.0018561883],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999417,0.0000116227275,0.000005952465,0.000010210273,0.000015600657,0.000014865156],"domain_scores_gemma":[0.9999529,0.0000047186445,0.000011726155,0.000006158177,0.000012058092,0.000012483225],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019234282,0.0002956886,0.0002339631,0.00026497425,0.0001601541,0.00025395027,0.00033818732,0.0002118185,0.00087572506],"category_scores_gemma":[0.0001293149,0.00012665102,0.0002519846,0.00018167586,0.0001571928,0.00021675063,0.00015619906,0.00031324054,0.00021674525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002091404,0.00017328975,0.0002112768,0.00007650691,0.000017557832,0.000090044145,0.00003085377,0.0012517354,0.9872399,0.00038642637,0.00009384798,0.010219476],"study_design_scores_gemma":[0.00016253791,0.0034041964,0.0019482195,0.000014908042,0.00008657139,0.00024556866,0.000027905278,0.0017554547,0.9834714,0.00012075982,0.00874378,0.000018758048],"about_ca_topic_score_codex":0.00087117386,"about_ca_topic_score_gemma":0.0017933693,"teacher_disagreement_score":0.00087572506,"about_ca_system_score_codex":0.00031774107,"about_ca_system_score_gemma":0.00025868427,"threshold_uncertainty_score":0.0029295683},"labels":[],"label_agreement":null},{"id":"W1975102154","doi":"10.1016/j.bmcl.2014.12.042","title":"Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Pharmacophore; NS5A; Chemistry; Combinatorial chemistry; Ledipasvir; Daclatasvir; Amide; Stereochemistry; Biochemistry; Hepacivirus","score_opus":0.03855950885867923,"score_gpt":0.3025955488224487,"score_spread":0.26403603996376945,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975102154","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9645256,0.0077101532,0.01026591,0.00018071456,0.00011364193,0.0005926273,0.0011125386,0.0001914005,0.015307498],"genre_scores_gemma":[0.9851474,0.0039157327,0.0062571927,0.00012405291,0.000020597941,0.0001280253,0.0007480777,0.00002658608,0.0036323825],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991703,0.000015310856,0.000006697313,0.000015558418,0.000020825066,0.000024590774],"domain_scores_gemma":[0.9999567,0.0000044059807,0.0000103217035,0.0000054231873,0.000008839607,0.000014296796],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021325445,0.0003971616,0.00030333584,0.00022319151,0.00019407766,0.00022171024,0.0003560506,0.00020524571,0.0017996596],"category_scores_gemma":[0.00012011024,0.0001500244,0.0002475251,0.0001455776,0.00013465979,0.0002177698,0.00019617012,0.00035628254,0.0004639633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00081314135,0.00044531707,0.00021662243,0.0002704926,0.00006864883,0.00022573705,0.000055801094,0.003934884,0.9625893,0.0012336108,0.0007357752,0.029410653],"study_design_scores_gemma":[0.0003562892,0.0054892274,0.0009287228,0.000033493743,0.00009238337,0.00030218487,0.000028809216,0.0032618372,0.97519284,0.00019964042,0.014088181,0.000026387628],"about_ca_topic_score_codex":0.00044211012,"about_ca_topic_score_gemma":0.0013412801,"teacher_disagreement_score":0.0017996596,"about_ca_system_score_codex":0.00026606128,"about_ca_system_score_gemma":0.00024282017,"threshold_uncertainty_score":0.0060204864},"labels":[],"label_agreement":null},{"id":"W1975223905","doi":"10.1016/j.bmcl.2008.04.009","title":"Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Liver physiology and pathology","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; In vitro; Kinase; Tyrosine kinase; In vivo; Potency; Pyridine; Structure–activity relationship; VEGF receptors; Receptor tyrosine kinase; Stereochemistry; Lead compound; Chemical synthesis; Pharmacology; Biochemistry; Cancer research; Signal transduction; Medicinal chemistry; Biology","score_opus":0.017513556384658215,"score_gpt":0.21760633371804253,"score_spread":0.20009277733338432,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975223905","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9134455,0.037170563,0.023157788,0.0010159395,0.00042634652,0.00066527637,0.0016122652,0.0006643159,0.021842187],"genre_scores_gemma":[0.9652905,0.014124692,0.0076435795,0.00033684485,0.00007027366,0.00017010047,0.0012145414,0.000021635873,0.01112791],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991477,0.000011140028,0.000005354339,0.00001401046,0.000024030307,0.000030672887],"domain_scores_gemma":[0.99994636,0.000008142536,0.000012196833,0.0000045475035,0.000008401095,0.000020420146],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024667036,0.0004066018,0.00034426406,0.0003151823,0.00023621485,0.00031687613,0.0005198219,0.00031974117,0.002351041],"category_scores_gemma":[0.00021263154,0.00018713587,0.00019315275,0.0002109655,0.00017812365,0.00024893045,0.00030174223,0.0006748529,0.00041398132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00060569914,0.0003826231,0.0005369422,0.0006248987,0.00007828539,0.0006853993,0.00020309868,0.0029854872,0.92629397,0.0024892646,0.002792911,0.062321376],"study_design_scores_gemma":[0.001055093,0.006869882,0.008581876,0.00011730994,0.00020330033,0.0027698076,0.000106452135,0.009682383,0.89044935,0.0007436825,0.07933134,0.00008948938],"about_ca_topic_score_codex":0.0011915728,"about_ca_topic_score_gemma":0.0058658924,"teacher_disagreement_score":0.002351041,"about_ca_system_score_codex":0.00044613157,"about_ca_system_score_gemma":0.00029422462,"threshold_uncertainty_score":0.007865012},"labels":[],"label_agreement":null},{"id":"W1975625028","doi":"10.1016/s0960-894x(03)00542-0","title":"Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Lipophilicity; Ether; Steric effects; Antibacterial activity; Glycopeptide; Stereochemistry; Chemical synthesis; Organic chemistry; Combinatorial chemistry; Antibiotics; In vitro; Bacteria; Biochemistry","score_opus":0.020877102377138548,"score_gpt":0.23974967578929068,"score_spread":0.21887257341215213,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975625028","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99290246,0.0020526603,0.0019614717,0.000043297416,0.000027368138,0.000074471325,0.0002503372,0.000018911633,0.0026690045],"genre_scores_gemma":[0.99240994,0.0020204517,0.0027928888,0.000036136928,0.0000119435435,0.000024009538,0.00037531633,0.000013399128,0.0023159457],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998976,0.000023434572,0.000009478921,0.000011305534,0.000030558323,0.00002756973],"domain_scores_gemma":[0.99993396,0.0000074226427,0.000016094202,0.000008637079,0.000012764508,0.000021088954],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612108,0.00024138579,0.00022290145,0.0001479139,0.00011486446,0.00015287267,0.00019234797,0.00021177065,0.00086489914],"category_scores_gemma":[0.00014186339,0.00008483425,0.00015703145,0.00015283332,0.00012665766,0.00018584651,0.0001793355,0.0002683045,0.00017885308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00045117654,0.00006613817,0.00016265793,0.000052751326,0.000012441829,0.00017958463,0.000021903834,0.00054937333,0.9928376,0.00019757758,0.000040651645,0.0054281917],"study_design_scores_gemma":[0.000042778825,0.001022031,0.0009440976,0.0000041086373,0.000019930214,0.00014892625,0.0000108275235,0.000281597,0.99456465,0.000030794454,0.0029254702,0.000004731196],"about_ca_topic_score_codex":0.0004892537,"about_ca_topic_score_gemma":0.00070590526,"teacher_disagreement_score":0.00086489914,"about_ca_system_score_codex":0.00018634957,"about_ca_system_score_gemma":0.00017584817,"threshold_uncertainty_score":0.0028933287},"labels":[],"label_agreement":null},{"id":"W1975635277","doi":"10.1016/j.bmcl.2006.12.017","title":"Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; IκB kinase; Stereochemistry; Chemical synthesis; IC50; Biological activity; Tricyclic; Structure–activity relationship; In vitro; Biochemistry; Signal transduction; NF-κB","score_opus":0.015821871551194425,"score_gpt":0.24153736283477092,"score_spread":0.22571549128357649,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975635277","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95692116,0.02003503,0.010902139,0.0004233364,0.00026171134,0.00032374414,0.0010443265,0.00019669266,0.009891922],"genre_scores_gemma":[0.983931,0.0065642167,0.005061559,0.000086476895,0.000045006967,0.00007606818,0.00066060165,0.000016388292,0.0035586522],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998869,0.000024872157,0.000013654824,0.000012005307,0.000031487747,0.000031045605],"domain_scores_gemma":[0.9999207,0.000010882864,0.000020256888,0.000007227874,0.000017345417,0.00002347596],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023594362,0.00035317068,0.00033261537,0.0002610265,0.0001750223,0.00017984443,0.000498707,0.0002340818,0.0016994657],"category_scores_gemma":[0.00019285224,0.00015015807,0.00020836251,0.00018159064,0.00017335494,0.00020535318,0.00015908974,0.00033724928,0.00040429106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004682292,0.00015205353,0.0001290122,0.00021296697,0.000019243678,0.0002977322,0.000038698567,0.00092197384,0.98851275,0.00047564923,0.00024544538,0.008526417],"study_design_scores_gemma":[0.00034799054,0.00360037,0.001389421,0.000021669926,0.00007241193,0.00045390156,0.000027275917,0.0013120051,0.98136824,0.00012778913,0.011259254,0.000019631121],"about_ca_topic_score_codex":0.00065238733,"about_ca_topic_score_gemma":0.0013319211,"teacher_disagreement_score":0.0016994657,"about_ca_system_score_codex":0.00028303667,"about_ca_system_score_gemma":0.00025733598,"threshold_uncertainty_score":0.0056853294},"labels":[],"label_agreement":null},{"id":"W1975763156","doi":"10.1016/j.bmcl.2013.07.036","title":"N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Agonist; Partial agonist; Opioid; Antagonist; μ-opioid receptor; Pharmacology; Opioid peptide; Stereochemistry; Receptor; Biochemistry; Medicine","score_opus":0.02005718375744591,"score_gpt":0.23669253429478473,"score_spread":0.21663535053733882,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975763156","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9977258,0.0001419541,0.00096350035,0.000044606837,0.000018475297,0.000008429167,0.00014518289,0.00001214789,0.0009398382],"genre_scores_gemma":[0.9980167,0.00009891569,0.00080573146,0.000043495416,0.0000062341182,0.000008981411,0.00030272503,0.0000159076,0.00070138753],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998989,0.000014274948,0.000008255823,0.000022725902,0.00001882542,0.000037079935],"domain_scores_gemma":[0.9998062,0.000041902935,0.00004868949,0.000027546343,0.000013856787,0.000061728926],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112997615,0.00022209933,0.00015569318,0.000056417713,0.00011881414,0.00018362062,0.00020109369,0.00031269717,0.00166648],"category_scores_gemma":[0.00021160008,0.000099518074,0.00018476254,0.000073570496,0.00023746675,0.00019710607,0.00018663959,0.00058014784,0.00045170746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025587363,0.000016043366,0.00011938115,0.0000111835325,0.0000034230893,0.00014428693,0.000006594642,0.00004782549,0.9985606,0.00007436412,0.000020579258,0.0007398031],"study_design_scores_gemma":[0.000025319643,0.000172257,0.0043979688,0.0000035903765,0.0000066885937,0.0005677443,0.000015916474,0.00049135607,0.99359,0.000050300896,0.0006729367,0.0000059379795],"about_ca_topic_score_codex":0.00032149875,"about_ca_topic_score_gemma":0.00034355719,"teacher_disagreement_score":0.00166648,"about_ca_system_score_codex":0.0001356537,"about_ca_system_score_gemma":0.00014297274,"threshold_uncertainty_score":0.0055749416},"labels":[],"label_agreement":null},{"id":"W1975958715","doi":"10.1016/j.bmcl.2010.02.031","title":"2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: Optimization of human microsomal stability","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Morpholine; Tetrahydropyran; In vivo; Stereochemistry; Microsome; Metabolic stability; Combinatorial chemistry; In vitro; Biochemistry; Medicinal chemistry; Organic chemistry; Ring (chemistry)","score_opus":0.005748385617925967,"score_gpt":0.2289764467744912,"score_spread":0.22322806115656524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975958715","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9718721,0.00988851,0.008750727,0.00021524509,0.00008933328,0.000086185224,0.00048979814,0.00025937526,0.008348692],"genre_scores_gemma":[0.9870864,0.00444541,0.0032388223,0.00006205037,0.000027608574,0.00007216389,0.0004232719,0.000025756142,0.004618393],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998869,0.000031655516,0.0000069782536,0.000014402563,0.000023066712,0.000036872912],"domain_scores_gemma":[0.99997044,0.0000050973413,0.000008331873,0.0000028900208,0.0000044061344,0.000008877746],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018761147,0.00026552708,0.0002372375,0.00016005473,0.0001372232,0.0001484831,0.00021682524,0.00015505096,0.0017357896],"category_scores_gemma":[0.00011498862,0.00013041428,0.00010993253,0.00022283771,0.00010406835,0.00013919365,0.00018866482,0.0002838739,0.00070938334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005672059,0.00008739519,0.00015234305,0.00011250772,0.000012797845,0.00012904438,0.00005797065,0.0006241503,0.9846022,0.0006561463,0.00038645812,0.012611816],"study_design_scores_gemma":[0.00013852425,0.0014959613,0.0016083906,0.0000096461745,0.00002973371,0.00036805944,0.000024515753,0.00090405863,0.98496336,0.00009122182,0.010352484,0.000013937425],"about_ca_topic_score_codex":0.0004921223,"about_ca_topic_score_gemma":0.0013689531,"teacher_disagreement_score":0.0017357896,"about_ca_system_score_codex":0.0002283453,"about_ca_system_score_gemma":0.00022914898,"threshold_uncertainty_score":0.005806744},"labels":[],"label_agreement":null},{"id":"W1976211868","doi":"10.1016/j.bmcl.2010.07.070","title":"Synthesis of MRI contrast agents derived from DOTAM-Gly-l-Phe-OH incorporating a disulfide bridge: Conjugation to a cell penetrating peptide and preparation of a dimeric agent","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Conjugate; Peptide; Disulfide bond; Combinatorial chemistry; Iodine; Cyclic peptide; Stereochemistry; Organic chemistry; Biochemistry","score_opus":0.01234880193545597,"score_gpt":0.24135050076933817,"score_spread":0.22900169883388222,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1976211868","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9436526,0.0030044676,0.048139054,0.0002679439,0.000116557305,0.00040188825,0.00052108243,0.00024458606,0.0036518644],"genre_scores_gemma":[0.9375128,0.0016489369,0.053186145,0.00020860572,0.000037143807,0.00023305319,0.0009574984,0.000112303416,0.006103613],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999112,0.000014474405,0.000012376742,0.00002200419,0.000017971752,0.000021894628],"domain_scores_gemma":[0.9998858,0.00001644164,0.00002919946,0.000015915386,0.000019480643,0.000033220465],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026872818,0.00041152805,0.00042297394,0.00016899822,0.00021055418,0.00023888402,0.00029320954,0.0003699749,0.0007567014],"category_scores_gemma":[0.00023984253,0.0003105889,0.00022749668,0.00018929622,0.00017122949,0.0002929385,0.00026455094,0.0005729574,0.00054536056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00004882285,0.000024238265,0.000027962744,0.00003962666,0.0000045933875,0.000050072875,0.00001843519,0.000086107335,0.9980439,0.00016845512,0.00004446643,0.0014432324],"study_design_scores_gemma":[0.00001175881,0.00007336294,0.0000882078,0.0000015695989,0.000006844673,0.000070612965,0.0000028503387,0.00023368564,0.99777514,0.000018223796,0.0017151115,0.0000025819886],"about_ca_topic_score_codex":0.00018045043,"about_ca_topic_score_gemma":0.00030023284,"teacher_disagreement_score":0.0007567014,"about_ca_system_score_codex":0.00022686289,"about_ca_system_score_gemma":0.00021718134,"threshold_uncertainty_score":0.0025314689},"labels":[],"label_agreement":null},{"id":"W1976436265","doi":"10.1016/j.bmcl.2014.12.089","title":"Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone health and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Chemistry; Farnesyl pyrophosphate; Active site; Stereochemistry; Binding site; Pyrophosphate; Allosteric enzyme; Enzyme; ATP synthase; Cofactor; Biochemistry","score_opus":0.025642684131822795,"score_gpt":0.29250973730158997,"score_spread":0.26686705316976717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1976436265","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99448967,0.0005782377,0.0032644006,0.0001952866,0.000012663064,0.000012776142,0.000088169756,0.000036138656,0.0013226378],"genre_scores_gemma":[0.9980178,0.0001761116,0.0011359289,0.00005291608,0.0000034541501,0.0000048088805,0.000059018133,0.0000061987557,0.0005437612],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985814,0.00003093029,0.0000039228457,0.000024030254,0.00004930716,0.00003357176],"domain_scores_gemma":[0.9998859,0.000062075436,0.000016735474,0.000007671184,0.000008742029,0.000018987485],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022276441,0.00020435196,0.00037056496,0.00010199692,0.00022718521,0.0004104815,0.00035373375,0.0004173351,0.0024250965],"category_scores_gemma":[0.00037675514,0.00021199005,0.0001677084,0.00009869795,0.00040031195,0.00030593987,0.00019027176,0.0006985921,0.00034243477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00069997134,0.00008110812,0.001163124,0.00007894356,0.000013893125,0.00010728851,0.000053156105,0.002569088,0.98957574,0.0013154927,0.00011403824,0.0042280597],"study_design_scores_gemma":[0.00011363244,0.00055974,0.005336452,0.00001759357,0.000028500237,0.0003461196,0.00018676167,0.024452306,0.9653837,0.00097009685,0.0025742135,0.000030819425],"about_ca_topic_score_codex":0.0014806088,"about_ca_topic_score_gemma":0.0022278978,"teacher_disagreement_score":0.0024250965,"about_ca_system_score_codex":0.0003860325,"about_ca_system_score_gemma":0.00034255933,"threshold_uncertainty_score":0.008112788},"labels":[],"label_agreement":null},{"id":"W1977293014","doi":"10.1016/s0960-894x(02)00025-2","title":"Potent nonsteroidal progesterone receptor agonists: Synthesis and SAR study of 6-aryl benzoxazines","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Ovariectomized rat; Aryl; Agonist; Chemical synthesis; In vivo; Progesterone receptor; Receptor; Pharmacology; Mifepristone; Stereochemistry; Endocrinology; Internal medicine; In vitro; Hormone; Biochemistry; Estrogen receptor; Organic chemistry; Medicine; Alkyl; Pregnancy","score_opus":0.008087172827368603,"score_gpt":0.2004361406382155,"score_spread":0.1923489678108469,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977293014","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9273868,0.03815207,0.02046639,0.0010181752,0.0001793734,0.00037241806,0.0011687037,0.00019352006,0.011062348],"genre_scores_gemma":[0.9489552,0.032590557,0.0072105755,0.00026656824,0.00006431387,0.00012415624,0.0009315839,0.000023131055,0.0098338965],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999242,0.000015245935,0.000005775105,0.000008657479,0.000019366931,0.000026881113],"domain_scores_gemma":[0.99994886,0.000008093518,0.000013682799,0.000005262908,0.0000091541715,0.00001490231],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021599821,0.00030190567,0.0003350312,0.00016475254,0.00014306439,0.00014230642,0.00031621463,0.00016482512,0.0017562605],"category_scores_gemma":[0.00016583642,0.00015797219,0.00017328272,0.00015987396,0.00018311359,0.0002272747,0.00025111518,0.00044028737,0.0005900568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00075661927,0.0002162713,0.00046471812,0.0005225848,0.00003752165,0.00053973426,0.00019337502,0.002524254,0.95979714,0.002460906,0.0009381308,0.031548712],"study_design_scores_gemma":[0.00061022077,0.0074327174,0.0072405557,0.000083615,0.00011097806,0.0013925609,0.00013482575,0.00303486,0.9210713,0.0007258783,0.05810287,0.00005952244],"about_ca_topic_score_codex":0.0009203429,"about_ca_topic_score_gemma":0.00256995,"teacher_disagreement_score":0.0017562605,"about_ca_system_score_codex":0.00024879424,"about_ca_system_score_gemma":0.00025322783,"threshold_uncertainty_score":0.00587523},"labels":[],"label_agreement":null},{"id":"W1977445418","doi":"10.1016/j.bmcl.2008.01.076","title":"Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Phosphate; Fructose; Biochemistry; Mannitol; Stereochemistry","score_opus":0.013327115387600787,"score_gpt":0.2503371934110139,"score_spread":0.23701007802341312,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977445418","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9307491,0.010866781,0.048425406,0.00039475673,0.00030448922,0.0008282608,0.0009896156,0.0004067861,0.0070347902],"genre_scores_gemma":[0.95295644,0.004800105,0.035504594,0.00012278727,0.000082324856,0.00035231974,0.0017209833,0.000107038766,0.004353438],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996414,0.00007931922,0.000029940828,0.000058501053,0.00009922886,0.00009162417],"domain_scores_gemma":[0.9996861,0.00009573446,0.000030383275,0.000029508306,0.00008250906,0.00007581803],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006700749,0.00095626066,0.00076480274,0.0003828103,0.00034128316,0.0005189439,0.0008240659,0.0007033364,0.0013628685],"category_scores_gemma":[0.0007037578,0.0003880526,0.00030655068,0.00040198464,0.0002690135,0.00058100745,0.00032978374,0.000939379,0.00051647384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011232782,0.00033388223,0.00010130977,0.00013171026,0.000024055425,0.00008795535,0.000048046637,0.00082357315,0.9877928,0.0007402219,0.00018850672,0.008604743],"study_design_scores_gemma":[0.000054356726,0.00049265055,0.000093663286,0.000002831209,0.00001786627,0.000077271216,0.000007800292,0.0008008669,0.9965293,0.000029581352,0.0018865902,0.0000072083412],"about_ca_topic_score_codex":0.001737796,"about_ca_topic_score_gemma":0.00285912,"teacher_disagreement_score":0.001737796,"about_ca_system_score_codex":0.00060971105,"about_ca_system_score_gemma":0.0010234314,"threshold_uncertainty_score":0.004559219},"labels":[],"label_agreement":null},{"id":"W1977583482","doi":"10.1016/j.bmcl.2014.03.032","title":"An evaluation of selective deprotection conditions for the synthesis of RNA on a light labile solid support","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Vetenskapsrådet","keywords":"Chemistry; Methylamine; Amine gas treating; Cleavage (geology); Linker; Protecting group; Oligonucleotide; Guanine; Combinatorial chemistry; Selectivity; Nucleic acid; Cleave; Ammonia; Aqueous solution; Cytosine; RNA; Stereochemistry; Organic chemistry; Nucleotide; DNA; Biochemistry; Enzyme; Catalysis","score_opus":0.009853139417929976,"score_gpt":0.26928182984393756,"score_spread":0.2594286904260076,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977583482","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9869518,0.0027196931,0.008275416,0.000082281906,0.00003413241,0.000084743675,0.00024443085,0.00009001436,0.0015173852],"genre_scores_gemma":[0.9848364,0.002280144,0.010937898,0.000058399826,0.000038597056,0.00006719408,0.0004896802,0.000059638503,0.0012320025],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997218,0.000062252686,0.000020453073,0.000059229173,0.00007985609,0.000056356537],"domain_scores_gemma":[0.99951375,0.00021564327,0.00012213358,0.000041565672,0.000062745356,0.000044123637],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00047564504,0.00047540228,0.00030166947,0.00022131443,0.00020821796,0.0003248695,0.00039379083,0.00042366562,0.0014999163],"category_scores_gemma":[0.0007541519,0.00019053699,0.00017929293,0.00018193328,0.00024060869,0.00036072073,0.00021253142,0.00040100078,0.00052035257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027113338,0.000034658926,0.00006992741,0.0001128773,0.000006428093,0.000052051695,0.000025119763,0.00013328054,0.9959831,0.00006149494,0.00003429786,0.0032156627],"study_design_scores_gemma":[0.000015601963,0.000342842,0.00029121843,0.0000043993973,0.000010474373,0.0000545763,0.000010860405,0.0004064818,0.9981122,0.000011813235,0.0007334435,0.000006073676],"about_ca_topic_score_codex":0.0002992147,"about_ca_topic_score_gemma":0.00071689097,"teacher_disagreement_score":0.0014999163,"about_ca_system_score_codex":0.00016402818,"about_ca_system_score_gemma":0.00030704998,"threshold_uncertainty_score":0.0050177574},"labels":[],"label_agreement":null},{"id":"W1977780776","doi":"10.1016/j.bmcl.2011.03.081","title":"The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Glucuronidation; Pharmacokinetics; Antagonist; Potency; Pharmacology; Stereochemistry; Combinatorial chemistry; Receptor; Biochemistry; Microsome; In vitro","score_opus":0.011249401290517973,"score_gpt":0.23092867750686646,"score_spread":0.2196792762163485,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977780776","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9844758,0.00409284,0.004899051,0.00020370794,0.00008893674,0.00016514449,0.00032941086,0.000106946194,0.005638181],"genre_scores_gemma":[0.9852761,0.0032272495,0.0050865933,0.00013855792,0.00003795716,0.00009888294,0.0008238406,0.000038296075,0.0052726804],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998938,0.000033381555,0.000008418804,0.00001212768,0.000019932791,0.000032354328],"domain_scores_gemma":[0.9999137,0.00001667764,0.000016141386,0.000013862941,0.000018674884,0.000020897334],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024535146,0.00038245085,0.00044581507,0.00020243014,0.00021341514,0.00032418265,0.0005104958,0.0003803248,0.0021801621],"category_scores_gemma":[0.0003327689,0.00024943223,0.0002195044,0.00018977458,0.00023318808,0.00031232776,0.00024059559,0.0007229559,0.0006275791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000979446,0.0001570673,0.00022532995,0.00007999401,0.000026748834,0.00021198698,0.000080217535,0.0005603156,0.9808946,0.001136716,0.0002481605,0.015399409],"study_design_scores_gemma":[0.00019699041,0.0036898367,0.0016891652,0.000016214353,0.00007522351,0.0006022,0.000035738984,0.0020525993,0.9824854,0.00018874342,0.008938492,0.00002933756],"about_ca_topic_score_codex":0.00095560943,"about_ca_topic_score_gemma":0.0022602773,"teacher_disagreement_score":0.0021801621,"about_ca_system_score_codex":0.00039319004,"about_ca_system_score_gemma":0.00045067503,"threshold_uncertainty_score":0.0072933435},"labels":[],"label_agreement":null},{"id":"W1977978639","doi":"10.1016/s0960-894x(00)00084-6","title":"The synthesis and vasopressin (AVP) antagonist activity of a novel series of n-aroyl-2,4,5,6-tetrahydropyrazolo [3,4-d]thieno[3,2-b]azepines","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Electrolyte and hormonal disorders","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Azepine; Moiety; Vasopressin; Stereochemistry; Benzamide; Antagonist; Vasopressin Antagonists; Chemical synthesis; Vasopressin receptor; Arginine; Receptor; Internal medicine; In vitro; Biochemistry; Amino acid","score_opus":0.009460369270694107,"score_gpt":0.22623770592381734,"score_spread":0.21677733665312324,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1977978639","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95531416,0.018672502,0.010087385,0.00037744862,0.00019911288,0.00017025117,0.0010232191,0.00017987457,0.0139761],"genre_scores_gemma":[0.9727561,0.012572494,0.00594644,0.00017110539,0.000088259294,0.000066967375,0.0007742454,0.000019020286,0.0076053184],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996066,0.000006113647,0.0000048690767,0.000009857422,0.0000082797515,0.000010269372],"domain_scores_gemma":[0.9999628,0.0000051469906,0.000011171843,0.000003924035,0.0000051879033,0.00001169933],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007686904,0.00023575428,0.00020268506,0.00015123823,0.00014671555,0.00019104674,0.00025628656,0.00014532365,0.0015592959],"category_scores_gemma":[0.000088990586,0.000101280864,0.000107392676,0.00012421765,0.00015726312,0.00026848,0.0001640803,0.00034576573,0.0004315015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026013108,0.00008568516,0.00011480187,0.00019450653,0.000009039964,0.0002114369,0.00006809594,0.0005880342,0.98015726,0.00068182923,0.00034366924,0.017285522],"study_design_scores_gemma":[0.00019059131,0.003574535,0.0029876728,0.000030320327,0.000044700246,0.0010626671,0.00004215136,0.0018972438,0.9639973,0.00026793382,0.025878541,0.000026247764],"about_ca_topic_score_codex":0.00033885924,"about_ca_topic_score_gemma":0.0008854466,"teacher_disagreement_score":0.0015592959,"about_ca_system_score_codex":0.00016007989,"about_ca_system_score_gemma":0.00017723117,"threshold_uncertainty_score":0.00521636},"labels":[],"label_agreement":null},{"id":"W1978272271","doi":"10.1016/j.bmcl.2010.04.011","title":"Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"University at Albany","keywords":"Semisynthesis; Chemistry; Angiogenesis; Matrigel; Chorioallantoic membrane; Amino acid; Chemical synthesis; Biochemistry; In vitro; Internal medicine","score_opus":0.010156345294550383,"score_gpt":0.2331181957592812,"score_spread":0.2229618504647308,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1978272271","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9513135,0.02552041,0.00957863,0.00035553574,0.00017823641,0.00015789892,0.001147539,0.00009637377,0.011651812],"genre_scores_gemma":[0.9810848,0.008535032,0.0040019723,0.00014841411,0.00004617833,0.000058610956,0.00073500525,0.00002026518,0.00536967],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999597,0.00000787712,0.0000050000403,0.0000061783608,0.000010100582,0.000011115017],"domain_scores_gemma":[0.9999324,0.000011171632,0.000019898689,0.000009963753,0.000009986804,0.00001657337],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013803,0.00024545394,0.00017560387,0.00015187047,0.0001093238,0.00023121922,0.00021435875,0.00020249904,0.001965431],"category_scores_gemma":[0.00012980834,0.00009032569,0.00022279967,0.00013155185,0.0001331587,0.0002564569,0.0001842455,0.00049303274,0.00046544682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040081062,0.00007339101,0.00009565686,0.00013070679,0.000010031557,0.00016756202,0.000028271477,0.00021755886,0.9861602,0.00058064127,0.00016439708,0.011970829],"study_design_scores_gemma":[0.00009969355,0.0012324902,0.0013034652,0.000018666487,0.00003723841,0.00054106355,0.00003733527,0.00024051536,0.98395383,0.00031620482,0.012207524,0.000011950494],"about_ca_topic_score_codex":0.00021651434,"about_ca_topic_score_gemma":0.00035017641,"teacher_disagreement_score":0.001965431,"about_ca_system_score_codex":0.000170431,"about_ca_system_score_gemma":0.00022674917,"threshold_uncertainty_score":0.006575048},"labels":[],"label_agreement":null},{"id":"W1978599264","doi":"10.1016/j.bmcl.2007.01.116","title":"A new platinum complex of triazine demonstrates G1 arrest with novel biological profile in human breast cancer cell line, MDA-MB-468","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières; College of the North Atlantic; Memorial University of Newfoundland","funders":"","keywords":"Chemistry; Apoptosis; Superoxide dismutase; SOD1; Cisplatin; Cell culture; Cancer cell; Cancer; Biochemistry; Cancer research; Biology; Enzyme; Genetics","score_opus":0.024195532916714824,"score_gpt":0.2533227068259588,"score_spread":0.22912717390924398,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1978599264","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9895706,0.0031895796,0.0033064594,0.00016178969,0.00003730511,0.000059594528,0.00029902137,0.00020089555,0.0031746868],"genre_scores_gemma":[0.99426705,0.0008477268,0.0015433197,0.000049357743,0.000008893569,0.000016398155,0.00036480726,0.000019688783,0.0028828168],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994445,0.000007544344,0.0000040886666,0.000017410031,0.000014698403,0.000011907058],"domain_scores_gemma":[0.9999572,0.0000071781415,0.000010893136,0.0000067449123,0.0000056554954,0.00001238748],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007602632,0.00020255582,0.0003006645,0.00016420064,0.00014006654,0.00018815303,0.00033709354,0.0002807996,0.0012239733],"category_scores_gemma":[0.00011744464,0.00012283624,0.000106059786,0.00020504149,0.00012844004,0.00018219923,0.00012781548,0.00030197247,0.00025940346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001568032,0.000025429654,0.00009522666,0.000047684513,0.000008593486,0.000073026036,0.000021981017,0.000057314537,0.99749315,0.00008637416,0.00012341251,0.0018109628],"study_design_scores_gemma":[0.000044046417,0.00064946426,0.0011970719,0.0000032680912,0.000024676743,0.0005737714,0.000010535854,0.00042417,0.9947566,0.00002254065,0.0022900638,0.0000039502825],"about_ca_topic_score_codex":0.0006231765,"about_ca_topic_score_gemma":0.0009830513,"teacher_disagreement_score":0.0012239733,"about_ca_system_score_codex":0.00022518949,"about_ca_system_score_gemma":0.00012421292,"threshold_uncertainty_score":0.0040946007},"labels":[],"label_agreement":null},{"id":"W1978750894","doi":"10.1016/s0960-894x(00)00493-5","title":"Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":70,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Chemistry; Tyrosine kinase; Angiogenesis; Receptor tyrosine kinase; Tyrosine-protein kinase CSK; Kinase; Cancer research; Signal transduction; Tyrosine-kinase inhibitor; Platelet-derived growth factor receptor; Tyrosine; Protein-Tyrosine Kinases; Structure–activity relationship; Biochemistry; Cell biology; Receptor; In vitro; Internal medicine; Cancer; Growth factor; Biology; Medicine","score_opus":0.009813187631309573,"score_gpt":0.23432703643947053,"score_spread":0.22451384880816097,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1978750894","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96218824,0.021699958,0.009332119,0.0002601324,0.00009343919,0.00024694976,0.0005068439,0.00011774199,0.0055545955],"genre_scores_gemma":[0.98271114,0.008287554,0.004709524,0.00008955351,0.00003930988,0.000075518416,0.00071423315,0.000017743883,0.0033553804],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998294,0.000042249765,0.0000145348295,0.000021495369,0.00004195489,0.000050279363],"domain_scores_gemma":[0.999866,0.000029506942,0.000030166637,0.000013134098,0.0000303147,0.000030933068],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040078623,0.00038334663,0.0002895744,0.00033532135,0.00016542501,0.00021235236,0.00035846946,0.0002902624,0.0007695239],"category_scores_gemma":[0.0003464699,0.00021994143,0.00021245342,0.00019236337,0.00014048789,0.00024970036,0.00014305294,0.00039403187,0.00022900091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005043349,0.0001668387,0.00029419886,0.00011171332,0.00002742432,0.000109730456,0.00004584487,0.00092139986,0.98413557,0.000294783,0.00022953388,0.013158554],"study_design_scores_gemma":[0.00017604735,0.0022109975,0.0030429745,0.000012102793,0.0000509552,0.0003778576,0.000013281966,0.0013155175,0.98510575,0.000051895127,0.0076270653,0.000015626432],"about_ca_topic_score_codex":0.0008689972,"about_ca_topic_score_gemma":0.0026796027,"teacher_disagreement_score":0.0008689972,"about_ca_system_score_codex":0.0003429598,"about_ca_system_score_gemma":0.00020729544,"threshold_uncertainty_score":0.0025743246},"labels":[],"label_agreement":null},{"id":"W1979129343","doi":"10.1016/j.bmcl.2007.06.097","title":"Cyanine dye conjugates as probes for live cell imaging","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Camille and Henry Dreyfus Foundation; Arnold and Mabel Beckman Foundation; Alfred P. Sloan Foundation; National Science Foundation","keywords":"Cyanine; Chemistry; Fluorescence; Conjugate; Live cell imaging; Combinatorial chemistry; Absorption (acoustics); Chemical synthesis; Peptide; Photochemistry; Cell; Biochemistry; Optics; In vitro","score_opus":0.004991926715855919,"score_gpt":0.2339613329717584,"score_spread":0.22896940625590248,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979129343","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.61041373,0.0342809,0.32629448,0.0015480492,0.0006162899,0.0003447818,0.0006731926,0.0026116916,0.023216946],"genre_scores_gemma":[0.84736836,0.015162484,0.11345746,0.0005749448,0.00013574872,0.0006278106,0.000775608,0.00058277295,0.021314656],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99957985,0.00013819478,0.000019089031,0.00007469333,0.00011177745,0.000076459386],"domain_scores_gemma":[0.99965465,0.00015954334,0.00004800403,0.00004564851,0.000045611003,0.000046490906],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009533342,0.0007423472,0.0005405647,0.00063676416,0.0006386072,0.00083405053,0.0012371518,0.0012797748,0.0022713155],"category_scores_gemma":[0.00050981966,0.00071303116,0.00022165613,0.0005167353,0.00057268766,0.001139401,0.00070225744,0.0013704762,0.0008893378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001219714,0.000014646168,0.000046812704,0.00011366025,0.000006588614,0.0000948437,0.00004385442,0.00022732798,0.9917966,0.0022558516,0.00039679237,0.004880969],"study_design_scores_gemma":[0.000012424366,0.00004814235,0.0001360085,0.0000068669115,0.00000725754,0.0001412806,0.000009670553,0.0013298596,0.99284816,0.0002033816,0.005250365,0.0000066104476],"about_ca_topic_score_codex":0.0007438375,"about_ca_topic_score_gemma":0.0018014412,"teacher_disagreement_score":0.0022713155,"about_ca_system_score_codex":0.0013638331,"about_ca_system_score_gemma":0.00037996113,"threshold_uncertainty_score":0.009895325},"labels":[],"label_agreement":null},{"id":"W1979300135","doi":"10.1016/j.bmcl.2011.12.097","title":"Structurally diverse disaccharide analogs of antifreeze glycoproteins and their ability to inhibit ice recrystallization","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Disaccharide; Chemistry; Galactosamine; Recrystallization (geology); Monosaccharide; Glycoprotein; Stereochemistry; Antifreeze protein; Antifreeze; Biochemistry; Organic chemistry; Galactose","score_opus":0.019406726449653508,"score_gpt":0.19709937482014228,"score_spread":0.17769264837048876,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979300135","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9976896,0.0008348872,0.00040429085,0.000035607518,0.000012642412,0.000016591279,0.00012660057,0.000013791379,0.00086595205],"genre_scores_gemma":[0.99728274,0.00064593257,0.00054546265,0.000031111565,0.0000039419338,0.00000943448,0.00036337104,0.000008930903,0.0011090321],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999443,0.000009508663,0.000004087972,0.000006290275,0.000013016202,0.00002281086],"domain_scores_gemma":[0.9999391,0.000015727339,0.0000130425,0.000008125775,0.000008088231,0.000016016347],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012600631,0.00020977066,0.00016499055,0.000100903184,0.00008819218,0.0001721963,0.0002469252,0.000194098,0.0009178656],"category_scores_gemma":[0.00014786905,0.000104656094,0.00014399532,0.00013362244,0.00018752206,0.00015732477,0.000094009,0.0004859945,0.000119631775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046598137,0.000070640745,0.00015771983,0.000028514372,0.000009641491,0.000047827427,0.000029913,0.00038675152,0.9967399,0.00015392381,0.00007114748,0.0018379914],"study_design_scores_gemma":[0.00004375813,0.0006918532,0.0015234502,0.0000027083724,0.000012607534,0.00009741441,0.000019967649,0.00032995752,0.99563956,0.000025169864,0.0016088217,0.000004616755],"about_ca_topic_score_codex":0.0015153858,"about_ca_topic_score_gemma":0.001846612,"teacher_disagreement_score":0.0015153858,"about_ca_system_score_codex":0.00018642741,"about_ca_system_score_gemma":0.0001514648,"threshold_uncertainty_score":0.0030705333},"labels":[],"label_agreement":null},{"id":"W1979470279","doi":"10.1016/s0960-894x(00)00668-5","title":"Design and synthesis of tricyclic derivatives as high density lipoprotein cholesterol enhancers","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and pharmacological studies","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Pharmacophore; Regioselectivity; Tricyclic; Thio-; Aryl; Benzofuran; Stereochemistry; Combinatorial chemistry; Organic chemistry; Alkyl","score_opus":0.01664851948032327,"score_gpt":0.23767160921966374,"score_spread":0.22102308973934046,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979470279","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92930883,0.01791134,0.020952823,0.0005710881,0.00036089798,0.00055513094,0.0011642467,0.0003595294,0.02881602],"genre_scores_gemma":[0.96485114,0.009744617,0.014629909,0.00021709893,0.00004352459,0.00015271116,0.0006027995,0.000040813935,0.009717394],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998994,0.000020324533,0.000010601076,0.000015833924,0.00001767971,0.000036243317],"domain_scores_gemma":[0.99992955,0.000009191322,0.000017348364,0.000009253493,0.000013802782,0.000020750864],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020730059,0.00026950074,0.00033043802,0.00029806216,0.00019784435,0.00031257857,0.000612177,0.0002950488,0.0022403852],"category_scores_gemma":[0.00019970303,0.00018000517,0.00026133878,0.00027092177,0.0001900656,0.00020089169,0.00023004609,0.00041862464,0.00069687795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012085689,0.00028011415,0.0002699819,0.0008067164,0.000059366965,0.00094148854,0.00023049736,0.0032665178,0.92490333,0.0055395947,0.0015057045,0.06098809],"study_design_scores_gemma":[0.0003109217,0.0033065185,0.00068774674,0.000061356266,0.00009846834,0.00065406563,0.00006093914,0.0023842263,0.9554317,0.00042271154,0.036533043,0.0000482647],"about_ca_topic_score_codex":0.00065804773,"about_ca_topic_score_gemma":0.0012121288,"teacher_disagreement_score":0.0022403852,"about_ca_system_score_codex":0.0003408036,"about_ca_system_score_gemma":0.0002704428,"threshold_uncertainty_score":0.007494867},"labels":[],"label_agreement":null},{"id":"W1979600759","doi":"10.1016/j.bmcl.2008.12.095","title":"Discovery of μ-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada); University of Toronto","funders":"","keywords":"Chemistry; Stereochemistry; Ligand (biochemistry); Ring (chemistry); Catalysis; Combinatorial chemistry; Agonist; Partial agonist; Antagonist; Opioid; Amide; Receptor; Organic chemistry; Biochemistry","score_opus":0.009845157743178264,"score_gpt":0.2147570863371993,"score_spread":0.20491192859402105,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979600759","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9583455,0.003854697,0.024305312,0.00034975255,0.00016722734,0.00032985752,0.0004961161,0.00054371887,0.011607801],"genre_scores_gemma":[0.9787451,0.0018480511,0.013867324,0.00014091426,0.00003624269,0.000101896316,0.00034623625,0.00003989807,0.0048744087],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998692,0.000023514587,0.0000097037655,0.000026715694,0.000029432142,0.000041389405],"domain_scores_gemma":[0.99989426,0.000021714948,0.0000382676,0.0000090303565,0.0000132149435,0.000023438202],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023871369,0.00041228055,0.00036796823,0.00021843109,0.00019690358,0.00040112488,0.0005890973,0.0004327284,0.0014427444],"category_scores_gemma":[0.00027339775,0.00023160536,0.0002715217,0.00017500145,0.00020898151,0.0003338964,0.0003308604,0.000580371,0.0006253356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028255058,0.00009540909,0.00019276787,0.00018547979,0.000021095033,0.0004503058,0.00008904375,0.0009207823,0.982359,0.0020836003,0.0003804938,0.012939454],"study_design_scores_gemma":[0.000058862912,0.0006715096,0.0003225014,0.000010652991,0.000024886527,0.00044941195,0.000024068826,0.0017063431,0.9903867,0.00016781618,0.0061536506,0.000023531638],"about_ca_topic_score_codex":0.00027493632,"about_ca_topic_score_gemma":0.000783758,"teacher_disagreement_score":0.0014427444,"about_ca_system_score_codex":0.00037272458,"about_ca_system_score_gemma":0.00020752265,"threshold_uncertainty_score":0.0048264265},"labels":[],"label_agreement":null},{"id":"W1979854812","doi":"10.1016/j.bmcl.2014.10.004","title":"A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the xC− transporter","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency; TRIUMF","funders":"BC Cancer Agency; TRIUMF","keywords":"Chemistry; Oxidative stress; Transporter; Neurodegeneration; Pet imaging; Imaging agent; Biochemistry; Biomarker; Cystine; Positron emission tomography; In vivo; Cysteine; Neuroscience; Pathology; Enzyme; Biology","score_opus":0.007771178940506545,"score_gpt":0.23220988137968945,"score_spread":0.2244387024391829,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979854812","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.4506689,0.004877811,0.4999482,0.0020881386,0.00051812426,0.0015584866,0.0024280304,0.0015032052,0.03640908],"genre_scores_gemma":[0.72110087,0.0030635532,0.2448975,0.00050749053,0.00007502782,0.0010547916,0.0017430887,0.00023681938,0.02732085],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997912,0.00004754592,0.000012897656,0.00005748395,0.000041515483,0.00004940336],"domain_scores_gemma":[0.999877,0.000034061428,0.000021371068,0.000027832117,0.000019992234,0.000019736868],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004920198,0.0008492323,0.00037322947,0.00030763805,0.0006283389,0.00043381072,0.0010099327,0.0012301193,0.004743045],"category_scores_gemma":[0.00030720924,0.0004922178,0.000363653,0.00022431926,0.00034221562,0.0005030684,0.00048128993,0.0015067777,0.0014615045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016359374,0.000039314236,0.00004995945,0.00010332714,0.000009774009,0.00022423737,0.00003805009,0.00017955128,0.9927556,0.0021600975,0.00047394194,0.0038025968],"study_design_scores_gemma":[0.000049476577,0.00020455672,0.00026726208,0.000013051046,0.000013303113,0.0005948681,0.000014973048,0.0007424595,0.9858747,0.00039625168,0.011806864,0.000022124952],"about_ca_topic_score_codex":0.0017235047,"about_ca_topic_score_gemma":0.002706336,"teacher_disagreement_score":0.004743045,"about_ca_system_score_codex":0.0004819161,"about_ca_system_score_gemma":0.000772755,"threshold_uncertainty_score":0.015867054},"labels":[],"label_agreement":null},{"id":"W1979865260","doi":"10.1016/j.bmcl.2008.08.060","title":"Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: A new class of selective norepinephrine reuptake inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Norepinephrine; Reuptake; Reuptake inhibitor; Norepinephrine transporter; Dopamine; Serotonin; Pharmacology; Neurotransmitter; Serotonin Uptake Inhibitors; Chemical synthesis; Biochemistry; In vitro; Internal medicine; Receptor; Medicine","score_opus":0.009718612047648194,"score_gpt":0.20984442009844276,"score_spread":0.20012580805079455,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979865260","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8931211,0.033700537,0.025697464,0.0014925294,0.00051610573,0.0006874902,0.0031044066,0.00056776643,0.041112453],"genre_scores_gemma":[0.9383597,0.020462992,0.016265273,0.00044110933,0.00017658286,0.00038566577,0.0020144552,0.00008471876,0.021809628],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998895,0.000017425567,0.00001256712,0.00001956978,0.000024258226,0.000036665282],"domain_scores_gemma":[0.99994123,0.0000078615,0.000014396219,0.0000057903476,0.000010468968,0.00002017425],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016809357,0.0005093429,0.00033619793,0.000348248,0.00022926067,0.00034047427,0.0006171371,0.0003117322,0.0025474764],"category_scores_gemma":[0.00013386474,0.0002635148,0.0002442598,0.00020665329,0.00015141295,0.00041689049,0.00026050565,0.0005433927,0.0011054804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008357943,0.0004787734,0.000223352,0.0006156857,0.000034832603,0.0007573699,0.00012348391,0.001865716,0.93891126,0.0035057054,0.0018035896,0.050844464],"study_design_scores_gemma":[0.0004888079,0.004220296,0.0024851689,0.00006502091,0.00009472576,0.0013728313,0.000043179516,0.0023254228,0.93682295,0.0004893895,0.051518317,0.00007388445],"about_ca_topic_score_codex":0.00041194865,"about_ca_topic_score_gemma":0.0012010003,"teacher_disagreement_score":0.0025474764,"about_ca_system_score_codex":0.00027794033,"about_ca_system_score_gemma":0.00043970294,"threshold_uncertainty_score":0.008522153},"labels":[],"label_agreement":null},{"id":"W1979943751","doi":"10.1016/j.bmcl.2014.09.024","title":"Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: A search for novel nitric oxide donor anti-inflammatory agents","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Reactions of Organic Compounds","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Trifluoromethyl; Chemistry; Nitric oxide; Pyrazole; Medicinal chemistry; Piperazine; Organic chemistry","score_opus":0.023007190888954036,"score_gpt":0.2441513559294197,"score_spread":0.22114416504046566,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979943751","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9260868,0.016747879,0.03303611,0.00090783817,0.0003756527,0.00038747778,0.0012759408,0.00050780847,0.02067448],"genre_scores_gemma":[0.97262436,0.0063619427,0.013075426,0.00017751993,0.000056449757,0.00015693817,0.0005342601,0.000023395485,0.0069896635],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990964,0.000012762202,0.000007683689,0.0000130111575,0.000017684477,0.0000392555],"domain_scores_gemma":[0.99995065,0.000004779955,0.000016084221,0.000004043929,0.0000085828,0.00001585934],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019274102,0.00036325905,0.00026896116,0.0002575203,0.00021485578,0.0001545432,0.00063821016,0.00036509524,0.0020547993],"category_scores_gemma":[0.00014027451,0.00017228122,0.00023129488,0.00022363801,0.00015887887,0.00026121424,0.00020210263,0.00034101275,0.0006230322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000281888,0.00021180097,0.00024224674,0.0004867607,0.000024545909,0.0006942468,0.00019073643,0.0011522555,0.9693369,0.002816822,0.0010186502,0.02354325],"study_design_scores_gemma":[0.0003847956,0.0038788111,0.004285598,0.00007542109,0.00009506772,0.0015596972,0.000104757055,0.0038045244,0.9411487,0.00059730856,0.04400557,0.000059710354],"about_ca_topic_score_codex":0.00078729447,"about_ca_topic_score_gemma":0.002362724,"teacher_disagreement_score":0.0020547993,"about_ca_system_score_codex":0.00034256408,"about_ca_system_score_gemma":0.0004736369,"threshold_uncertainty_score":0.006874025},"labels":[],"label_agreement":null},{"id":"W1979949978","doi":"10.1016/s0960-894x(00)00266-3","title":"Template-directed interference footprinting for RNA based on inosine-specific cleavage","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Medical Research Council","keywords":"Inosine; Ribozyme; Footprinting; Chemistry; RNA; Mammalian CPEB3 ribozyme; DNA footprinting; VS ribozyme; Oligonucleotide; Cleavage (geology); Intron; Tetrahymena; Biochemistry; Stereochemistry; Nucleotide; Adenosine; DNA; Gene; Base sequence; Biology; Gene expression; Promoter","score_opus":0.014581490041393329,"score_gpt":0.22571822171234235,"score_spread":0.211136731670949,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1979949978","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.72801787,0.0022873057,0.2570078,0.00046898526,0.00038924636,0.0007175153,0.0012481633,0.0017009098,0.008162188],"genre_scores_gemma":[0.8649446,0.0011211807,0.12794012,0.00026984658,0.000057630907,0.00028580253,0.0018734316,0.00024534902,0.0032621236],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9991605,0.00021596893,0.000054959244,0.00022309882,0.00021251218,0.00013301653],"domain_scores_gemma":[0.9993031,0.00029502754,0.0001020296,0.00013332751,0.00007827873,0.000088240326],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010651682,0.0011166049,0.0006880797,0.0005183672,0.00042652062,0.00051660085,0.00080041954,0.0009459863,0.0021466233],"category_scores_gemma":[0.0006759549,0.00067296915,0.0009935915,0.00032182844,0.0006020416,0.00033832924,0.0003819582,0.0014200385,0.0008429359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012305721,0.000022341075,0.000032392163,0.000049180446,0.0000075730213,0.000035039848,0.00002078356,0.00009721045,0.99824584,0.00020505322,0.00004829291,0.0011132343],"study_design_scores_gemma":[0.000010247977,0.000050674324,0.00009475159,0.0000021356161,0.00000601405,0.000046305024,0.0000033885442,0.00046504635,0.99883133,0.000037979673,0.00044756415,0.000004473467],"about_ca_topic_score_codex":0.00042445632,"about_ca_topic_score_gemma":0.00095701584,"teacher_disagreement_score":0.0021466233,"about_ca_system_score_codex":0.000551112,"about_ca_system_score_gemma":0.0003740762,"threshold_uncertainty_score":0.007181227},"labels":[],"label_agreement":null},{"id":"W1980037975","doi":"10.1016/j.bmcl.2013.09.100","title":"3′,4′-Bis-difluoromethoxycinnamoylanthranilate (FT061): An orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital","funders":"National Health and Medical Research Council; Medical Research Council","keywords":"Diabetic nephropathy; Chemistry; Albuminuria; Nephropathy; Tranilast; Pharmacology; Kidney; Diabetes mellitus; Potency; Bioavailability; Oral administration; Fibrosis; Endocrinology; Internal medicine; Medicine; Biochemistry; In vitro","score_opus":0.02144582235033241,"score_gpt":0.25947557730057047,"score_spread":0.23802975495023806,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1980037975","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98632705,0.00401441,0.0038785315,0.00050151994,0.00019534433,0.0000675845,0.00051820365,0.0005161811,0.003981201],"genre_scores_gemma":[0.9915529,0.0024112132,0.0027991391,0.00013331365,0.00007695988,0.000047955855,0.00061207276,0.000022169073,0.0023442737],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991596,0.000012195706,0.000005529856,0.000012697018,0.000016778838,0.000036858128],"domain_scores_gemma":[0.9999244,0.000009776533,0.000021169071,0.0000062531094,0.000008768258,0.000029514298],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019835851,0.00055395585,0.0004282827,0.0004357323,0.000258912,0.00015679117,0.0003732809,0.0005654411,0.001373989],"category_scores_gemma":[0.000120672994,0.00017260695,0.00032531237,0.00021967043,0.00024787724,0.0002966973,0.00009083756,0.0007158482,0.00045453184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012618698,0.00020175576,0.00008551484,0.00007417544,0.000008591304,0.00012856605,0.000010248659,0.00007288985,0.9915489,0.00014033375,0.00020469523,0.006262381],"study_design_scores_gemma":[0.00024808536,0.0019927006,0.0022043916,0.0000063519415,0.00003482956,0.00042127198,0.000010145215,0.00045990196,0.99260336,0.00003781802,0.001972566,0.000008566371],"about_ca_topic_score_codex":0.0011021617,"about_ca_topic_score_gemma":0.0011588141,"teacher_disagreement_score":0.001373989,"about_ca_system_score_codex":0.00023131604,"about_ca_system_score_gemma":0.00033996458,"threshold_uncertainty_score":0.004596412},"labels":[],"label_agreement":null},{"id":"W1980221804","doi":"10.1016/j.bmcl.2010.04.108","title":"Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"University of Waterloo","keywords":"Chemistry; Cholinesterase; Enzyme inhibitor; Stereochemistry; Chemical synthesis; Combinatorial chemistry; Enzyme; Pharmacology; Biochemistry; In vitro","score_opus":0.033649388478155025,"score_gpt":0.29870320953667323,"score_spread":0.2650538210585182,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1980221804","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95199895,0.024199966,0.013339946,0.00029114413,0.00020211363,0.00059014687,0.0010101635,0.00023405984,0.008133536],"genre_scores_gemma":[0.9699772,0.009995718,0.014374505,0.000113843256,0.000034567656,0.00017116597,0.0008675763,0.00003482821,0.004430563],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999764,0.00006757706,0.000031263844,0.000035871937,0.00005065141,0.000050653296],"domain_scores_gemma":[0.9998673,0.000020308358,0.00003472746,0.000014803179,0.000033091572,0.000029749728],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004910701,0.00044755856,0.0005114117,0.00038204071,0.00026386828,0.00043220236,0.0007276301,0.00055992545,0.0016005582],"category_scores_gemma":[0.00040663453,0.00029143062,0.00032932346,0.0002905883,0.00019477226,0.00032957282,0.00023496505,0.00052571815,0.00042113787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007657247,0.0002653977,0.00024084328,0.0005534896,0.000051081355,0.00038064952,0.00013716999,0.0038046895,0.96169204,0.0015857682,0.00039395006,0.03012915],"study_design_scores_gemma":[0.00030784184,0.005743296,0.0009383808,0.000040592033,0.00009797511,0.0004821805,0.000045094024,0.0030147524,0.97086126,0.00016034661,0.018266892,0.000041392716],"about_ca_topic_score_codex":0.0010919549,"about_ca_topic_score_gemma":0.0027531555,"teacher_disagreement_score":0.0016005582,"about_ca_system_score_codex":0.00056562165,"about_ca_system_score_gemma":0.00053178024,"threshold_uncertainty_score":0.0053544044},"labels":[],"label_agreement":null},{"id":"W1981167445","doi":"10.1016/s0960-894x(00)00523-0","title":"Parallel synthesis of isatin-based serine protease inhibitors","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Isatin; Chemistry; Proteases; Serine; Reagent; Serine protease; Serine Proteinase Inhibitors; Combinatorial chemistry; Catalysis; Chemical synthesis; Stoichiometry; Protease; Biochemistry; Organic chemistry; Enzyme; In vitro","score_opus":0.004870046580270776,"score_gpt":0.20038060465256916,"score_spread":0.1955105580722984,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1981167445","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8330858,0.016672803,0.1129533,0.0008177038,0.0007372045,0.0007448495,0.0014993123,0.0009139513,0.032575104],"genre_scores_gemma":[0.9106331,0.010213234,0.06380267,0.00023912694,0.00008877609,0.00029808056,0.0015415046,0.00013363856,0.013049945],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997906,0.000027507114,0.000020027717,0.000036533565,0.00006302449,0.00006233706],"domain_scores_gemma":[0.9999242,0.00000877253,0.000019958543,0.000010650385,0.000018143404,0.000018359111],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000288335,0.00065633934,0.00054805307,0.00033007812,0.00022707519,0.00041751252,0.00042590205,0.00033883535,0.0013388558],"category_scores_gemma":[0.00022142104,0.00026268826,0.00035322944,0.00042523837,0.00016997026,0.0004369494,0.00034951788,0.000977288,0.0006494896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003614058,0.00016222174,0.00009821639,0.00029401746,0.00006524951,0.00028334718,0.00010874105,0.0026763896,0.96298736,0.002898133,0.000962389,0.029102571],"study_design_scores_gemma":[0.00009401471,0.00051426276,0.00024294588,0.00001133351,0.000042879594,0.00021303933,0.000014187669,0.0021423518,0.9807968,0.00041556623,0.015498085,0.000014550323],"about_ca_topic_score_codex":0.00038878707,"about_ca_topic_score_gemma":0.00096184725,"teacher_disagreement_score":0.0013388558,"about_ca_system_score_codex":0.0006468453,"about_ca_system_score_gemma":0.00047019738,"threshold_uncertainty_score":0.00469321},"labels":[],"label_agreement":null},{"id":"W1981201938","doi":"10.1016/j.bmcl.2004.09.013","title":"Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; Hamilton Health Sciences","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Anticonvulsant; Convulsant; Inhibitory postsynaptic potential; Pharmacology; Valproic Acid; Epilepsy; Stereochemistry; Neuroscience; Biochemistry; Psychology; Receptor","score_opus":0.025933369153179498,"score_gpt":0.2155746594020847,"score_spread":0.1896412902489052,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1981201938","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99742436,0.0013689911,0.0001467225,0.000042907963,0.000010299316,0.000010732998,0.00025196464,0.000009683279,0.00073429703],"genre_scores_gemma":[0.9985638,0.0005830923,0.000120206714,0.000021251322,0.000007914561,0.0000072565654,0.0002751375,0.00000267219,0.00041872682],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988854,0.000027838572,0.000019656341,0.000012327717,0.000027791117,0.000023834447],"domain_scores_gemma":[0.9995809,0.0001550338,0.000115426345,0.000027547334,0.00005486033,0.0000662281],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026204612,0.00021670309,0.00035205143,0.00034877413,0.00010069825,0.0002445975,0.00012510527,0.0001790604,0.0011931714],"category_scores_gemma":[0.00065004785,0.000112784684,0.00024887727,0.00030795144,0.0002051782,0.0002033083,0.00008843868,0.0003804383,0.000176505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.010227848,0.00041614068,0.017885212,0.00015283038,0.00032749842,0.00036319203,0.00005804257,0.00092048524,0.9493095,0.00028360123,0.0002690003,0.019786632],"study_design_scores_gemma":[0.00048572486,0.015342924,0.1459712,0.000016806616,0.0005548866,0.0012772637,0.00010254381,0.0025507482,0.8304094,0.00022115544,0.00304564,0.000021698723],"about_ca_topic_score_codex":0.0007411742,"about_ca_topic_score_gemma":0.0013978573,"teacher_disagreement_score":0.0011931714,"about_ca_system_score_codex":0.00019013502,"about_ca_system_score_gemma":0.0001909932,"threshold_uncertainty_score":0.0039915442},"labels":[],"label_agreement":null},{"id":"W1981383014","doi":"10.1016/j.bmcl.2013.09.072","title":"Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Androsterone; Hydroxysteroid dehydrogenase; Stereochemistry; Dehydrogenase; Cyclohexanone; Active site; Enzyme; Steroid; Biochemistry; Hormone; Catalysis","score_opus":0.0121461281507453,"score_gpt":0.22785669764030703,"score_spread":0.21571056948956172,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1981383014","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85270566,0.04304623,0.033569448,0.0015592362,0.0013591951,0.00082653115,0.0037242281,0.0011377834,0.06207166],"genre_scores_gemma":[0.9703254,0.0121749295,0.005050942,0.00028022024,0.000078234465,0.00011061094,0.00095339096,0.000043850334,0.010982509],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999083,0.00001617312,0.000008668321,0.000010836726,0.000014278391,0.000041592157],"domain_scores_gemma":[0.99993443,0.000007913092,0.000011631425,0.0000063406783,0.0000124495755,0.000027254058],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018469473,0.000438478,0.00039768484,0.00044982458,0.00021264899,0.00027572302,0.0005555686,0.00028154644,0.0034878033],"category_scores_gemma":[0.0001486103,0.00019728564,0.00042099057,0.00032896321,0.00019865944,0.00023270347,0.00029201803,0.00042367872,0.001558211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011148775,0.00048105008,0.0008051219,0.0010993792,0.000113455346,0.0027681636,0.0005087423,0.0045805196,0.9142027,0.006519171,0.0034918443,0.06431489],"study_design_scores_gemma":[0.00056603807,0.004839766,0.005251888,0.00012509947,0.00018267584,0.0019710308,0.0001782807,0.0029007872,0.87498766,0.0013040241,0.10756084,0.00013191583],"about_ca_topic_score_codex":0.00086196203,"about_ca_topic_score_gemma":0.0017711011,"teacher_disagreement_score":0.0034878033,"about_ca_system_score_codex":0.0003040452,"about_ca_system_score_gemma":0.00045119255,"threshold_uncertainty_score":0.011667848},"labels":[],"label_agreement":null},{"id":"W1981585437","doi":"10.1016/j.bmcl.2006.01.122","title":"Anti-Plasmodium activity of imidazole–dioxolane compounds","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Plasmodium falciparum; Chemistry; Chinese hamster ovary cell; Heme; Dioxolane; Mechanism of action; Chloroquine; Biochemistry; In vitro; Inhibitory postsynaptic potential; Hemozoin; Receptor; Biology; Enzyme; Malaria","score_opus":0.008643519587933733,"score_gpt":0.23350249765000297,"score_spread":0.22485897806206923,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1981585437","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9827031,0.006831593,0.0010576352,0.00019034593,0.000077788034,0.000036733567,0.00025285827,0.000093486495,0.008756419],"genre_scores_gemma":[0.99037606,0.003111729,0.0009961835,0.000097623284,0.00004290334,0.000015318064,0.00033805068,0.0000070702163,0.0050151073],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999621,0.0000076159868,0.0000030421572,0.0000049922146,0.000005971059,0.000016209906],"domain_scores_gemma":[0.9999678,0.0000064976707,0.0000071662753,0.000002727071,0.0000054036295,0.0000104920455],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010048693,0.00020576126,0.00019141944,0.00018094509,0.0001355774,0.00015102595,0.0002571346,0.00013676404,0.0035844524],"category_scores_gemma":[0.00008609674,0.00007597783,0.00007926349,0.000112142625,0.000101404956,0.00011739549,0.00008647647,0.0002667247,0.0003286698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001198958,0.0001886904,0.00021538313,0.0002262299,0.000014489783,0.00018270493,0.000046887035,0.0003064316,0.98047525,0.0004618207,0.0005239266,0.016159214],"study_design_scores_gemma":[0.0001766335,0.0033825324,0.0022713677,0.000020185138,0.0000364964,0.000364824,0.000027881351,0.000671069,0.9840724,0.000076452445,0.008889106,0.000010971759],"about_ca_topic_score_codex":0.0004102904,"about_ca_topic_score_gemma":0.00065404736,"teacher_disagreement_score":0.0035844524,"about_ca_system_score_codex":0.00014516755,"about_ca_system_score_gemma":0.00010370162,"threshold_uncertainty_score":0.011991143},"labels":[],"label_agreement":null},{"id":"W1981668790","doi":"10.1016/j.bmcl.2010.10.018","title":"Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacophore; Antagonist; Receptor; Stereochemistry; Prostaglandin D2; Selectivity; Ligand binding assay; Prostanoid; Pharmacology; Biochemistry; Biology","score_opus":0.003378273421614663,"score_gpt":0.22279411752572126,"score_spread":0.21941584410410658,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1981668790","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9604083,0.010505645,0.016426187,0.0005607027,0.00016895309,0.00035043986,0.0007740775,0.00047394048,0.010331738],"genre_scores_gemma":[0.9783609,0.0050027044,0.008495027,0.00038290292,0.000117796706,0.00019356675,0.0010822626,0.00004213354,0.006322763],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983263,0.000031497206,0.000008963101,0.000021330663,0.000038845043,0.00006667431],"domain_scores_gemma":[0.9999341,0.000016921811,0.0000134371085,0.0000063682437,0.000008889088,0.000020255458],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027922186,0.0004515443,0.00071280054,0.00020076896,0.00020609346,0.0002211069,0.00078841805,0.00040345077,0.0016739721],"category_scores_gemma":[0.00026835233,0.0003081265,0.00014854938,0.0002241341,0.00023882593,0.00025822248,0.00023762055,0.0010044556,0.000583895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047172102,0.000121202924,0.00011876246,0.000078209945,0.0000142518265,0.00014793129,0.000043241096,0.00026589367,0.98779863,0.00048183318,0.00070938043,0.00974897],"study_design_scores_gemma":[0.001508211,0.006551395,0.00824876,0.000028063145,0.00014802454,0.0032774336,0.0000472768,0.0053750547,0.94880295,0.0003380598,0.025610678,0.00006411],"about_ca_topic_score_codex":0.0009969476,"about_ca_topic_score_gemma":0.003928147,"teacher_disagreement_score":0.0016739721,"about_ca_system_score_codex":0.00036406386,"about_ca_system_score_gemma":0.00030132453,"threshold_uncertainty_score":0.0055999756},"labels":[],"label_agreement":null},{"id":"W1982027099","doi":"10.1016/s0960-894x(03)00045-3","title":"Novel ether derivatives of mannopeptimycin glycopeptide antibiotic","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Ether; Glycopeptide; Antibacterial activity; Chemical synthesis; Glycopeptide antibiotic; Antibacterial agent; Cleavage (geology); Stereochemistry; Organic chemistry; Vancomycin; Antibiotics; Bacteria; Staphylococcus aureus; In vitro; Biochemistry","score_opus":0.015139139688660888,"score_gpt":0.217294016350286,"score_spread":0.20215487666162513,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982027099","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96296394,0.006658037,0.008782773,0.00030317865,0.00019611215,0.00013244478,0.00049553125,0.00009640342,0.020371629],"genre_scores_gemma":[0.98128784,0.0036213724,0.004326726,0.00012422752,0.000045689158,0.000042123585,0.00030181656,0.000020680016,0.010229592],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996173,0.0000069512703,0.000002539883,0.000004806622,0.000008437734,0.00001556284],"domain_scores_gemma":[0.9999783,0.0000023098905,0.000005094626,0.0000021601256,0.000002598891,0.000009427287],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006209791,0.00028967328,0.00020050057,0.00013778819,0.000117967895,0.00015661053,0.00020558554,0.00020812129,0.0021826655],"category_scores_gemma":[0.000055969405,0.000083919185,0.00012816513,0.00012323701,0.00011326765,0.0002482952,0.00023542205,0.00040130137,0.00038973533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00053476746,0.00010019133,0.00013435548,0.00011521861,0.000016331065,0.0006905232,0.000039748593,0.00056818203,0.9820364,0.0017959386,0.000317861,0.013650421],"study_design_scores_gemma":[0.00011628286,0.0014944242,0.0016730373,0.000012884903,0.000039873663,0.0007590184,0.000024807729,0.0011994278,0.971125,0.00037166002,0.023164347,0.000019369409],"about_ca_topic_score_codex":0.00026869666,"about_ca_topic_score_gemma":0.00036860176,"teacher_disagreement_score":0.0021826655,"about_ca_system_score_codex":0.00015273702,"about_ca_system_score_gemma":0.000111048816,"threshold_uncertainty_score":0.007301748},"labels":[],"label_agreement":null},{"id":"W1982236958","doi":"10.1016/j.bmcl.2014.04.003","title":"Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ligue Contre le Cancer; Institute of Cancer Research; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Chemistry; Docking (animal); Biological activity; Virtual screening; Apoptosis; ATPase; Programmed cell death; Cell growth; Biochemistry; Cell; Cell culture; Enzyme; Stereochemistry; In vitro; Drug discovery; Biology","score_opus":0.038996130181835814,"score_gpt":0.2849201967853545,"score_spread":0.2459240666035187,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982236958","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9128899,0.013093201,0.060197756,0.0010160356,0.00014875174,0.00104652,0.0007958763,0.0007290561,0.010082816],"genre_scores_gemma":[0.9666148,0.0058787675,0.021744004,0.00015156336,0.000011184042,0.00018993615,0.00063751434,0.00003140638,0.004740904],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987996,0.00002142881,0.000007919509,0.00001969804,0.00004127325,0.00002980747],"domain_scores_gemma":[0.99992716,0.000013101911,0.000018783092,0.000005524757,0.000016339587,0.000019029763],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035478067,0.0006693141,0.00067547837,0.00040132186,0.00036399427,0.000567979,0.0008996286,0.0003964085,0.0013727661],"category_scores_gemma":[0.00032276066,0.00029785166,0.00039241323,0.00036199548,0.0002386129,0.0003433771,0.0003075357,0.0008087958,0.00034693445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013993297,0.0012847715,0.0007673942,0.00079606957,0.00024640045,0.00078529393,0.00012400537,0.06881064,0.8555422,0.0046468857,0.0017195061,0.06387759],"study_design_scores_gemma":[0.0010779661,0.0045417175,0.0011899703,0.000068139765,0.00033885086,0.0009879172,0.000074800424,0.059827473,0.9121197,0.0007777891,0.01888921,0.00010643173],"about_ca_topic_score_codex":0.0016397584,"about_ca_topic_score_gemma":0.0029824006,"teacher_disagreement_score":0.0016397584,"about_ca_system_score_codex":0.00075503025,"about_ca_system_score_gemma":0.00057797524,"threshold_uncertainty_score":0.0054781437},"labels":[],"label_agreement":null},{"id":"W1982767183","doi":"10.1016/j.bmcl.2009.12.073","title":"Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Moiety; Phenylacetic acid; Stereochemistry; Arachidonate 5-lipoxygenase; Structural isomer; Chemical synthesis; Structure–activity relationship; Propanoic acid; Anti-inflammatory; Enzyme inhibitor; Enzyme; Virtual screening; In vitro; Biochemistry; Arachidonic acid; Pharmacology","score_opus":0.009930063360059803,"score_gpt":0.2545042664144384,"score_spread":0.2445742030543786,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982767183","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.983257,0.0050576692,0.0049889204,0.0001561113,0.00009572517,0.00014621577,0.00042005515,0.00016559602,0.0057127606],"genre_scores_gemma":[0.9910391,0.0035175295,0.0027537642,0.00007628538,0.000042346914,0.00005730685,0.0002739307,0.00001624741,0.0022235678],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987626,0.000024259663,0.000008716189,0.000015832034,0.000022498187,0.000052381885],"domain_scores_gemma":[0.99993014,0.000009341376,0.000022822785,0.000007437239,0.0000084247795,0.0000218503],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002504734,0.0004393095,0.0003444676,0.0003110218,0.0001881505,0.0001885082,0.00041880787,0.00035484563,0.0012305991],"category_scores_gemma":[0.00017702596,0.0002119852,0.0002675851,0.0002615983,0.00020099765,0.00021212794,0.00017799342,0.0004119533,0.00051058654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022688378,0.00023518967,0.00019725053,0.00014313926,0.000025871248,0.00042155708,0.000039354134,0.00067906483,0.98210484,0.0006320601,0.00032415066,0.012928681],"study_design_scores_gemma":[0.0005383873,0.005155286,0.0015805291,0.00001251332,0.00009321116,0.0008878771,0.000028216875,0.0010280762,0.9843805,0.000057780497,0.006212081,0.00002557737],"about_ca_topic_score_codex":0.00059425505,"about_ca_topic_score_gemma":0.00087365275,"teacher_disagreement_score":0.0012305991,"about_ca_system_score_codex":0.00019406823,"about_ca_system_score_gemma":0.0002657292,"threshold_uncertainty_score":0.0041167736},"labels":[],"label_agreement":null},{"id":"W1982960820","doi":"10.1016/j.bmcl.2007.02.047","title":"Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Efflux; Chemistry; Fluconazole; Pharmacokinetics; Candida albicans; Pharmacology; Candida glabrata; Quinazolinone; Biochemistry; Stereochemistry; Antifungal; Microbiology","score_opus":0.014802806550244484,"score_gpt":0.2469694852158753,"score_spread":0.23216667866563082,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982960820","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9835645,0.0074773915,0.0056265737,0.00021656675,0.00003408206,0.00013853057,0.0005424208,0.00014800152,0.0022518756],"genre_scores_gemma":[0.98992705,0.0029861904,0.0046366267,0.000056877412,0.000015480498,0.00005113329,0.0005316319,0.00003189274,0.0017631904],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998708,0.00003597355,0.000014445551,0.000021050308,0.000034032186,0.000023677003],"domain_scores_gemma":[0.9999281,0.000016957638,0.000022318089,0.000008633521,0.000013317059,0.00001069614],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027930865,0.00037449668,0.00042240016,0.00021999785,0.00012305699,0.00027952442,0.00030342722,0.00020857084,0.0013392741],"category_scores_gemma":[0.00039868066,0.00017035367,0.00023452548,0.00021726437,0.00013411518,0.00022714339,0.00013109103,0.00042356708,0.00022271599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017845104,0.00036098796,0.0007282052,0.00015069054,0.0000573456,0.00027068995,0.00006535765,0.003569661,0.9408066,0.0003643027,0.00065777637,0.051183958],"study_design_scores_gemma":[0.00064851885,0.0070134155,0.0058390563,0.000018582175,0.00016931102,0.0017519398,0.000029614144,0.005058573,0.96920276,0.0001242486,0.010098422,0.000045521145],"about_ca_topic_score_codex":0.00094506063,"about_ca_topic_score_gemma":0.0021770152,"teacher_disagreement_score":0.0013392741,"about_ca_system_score_codex":0.00028264566,"about_ca_system_score_gemma":0.00021095727,"threshold_uncertainty_score":0.004480362},"labels":[],"label_agreement":null},{"id":"W1983085893","doi":"10.1016/j.bmcl.2008.12.053","title":"Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Nitrile; Chemistry; Ketone; Cathepsin; Chemical synthesis; Biochemistry; Pharmacokinetics; Enzyme; Pharmacology; Organic chemistry; In vitro","score_opus":0.012118705823834433,"score_gpt":0.24992453168234416,"score_spread":0.23780582585850973,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1983085893","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97100216,0.006374938,0.011280084,0.00038429958,0.000107070075,0.00020071887,0.00027084068,0.00012484843,0.010254954],"genre_scores_gemma":[0.98837924,0.0043543256,0.004161967,0.0000918402,0.000020106696,0.00006330912,0.000182866,0.000018335873,0.0027278857],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998876,0.00002405623,0.000008148148,0.000016540465,0.000021129325,0.000042561893],"domain_scores_gemma":[0.99993205,0.000018961688,0.000016061082,0.000008634444,0.000008603341,0.000015685257],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004707499,0.000460395,0.0002518429,0.00022151713,0.00018899306,0.00026775047,0.00039415905,0.0003748812,0.0017162103],"category_scores_gemma":[0.00023659307,0.00017188839,0.0002646319,0.00015311353,0.00030850508,0.0006864896,0.00029606067,0.00051911036,0.0003350357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002497813,0.00052252226,0.00055285747,0.00067918573,0.0000830595,0.0011670361,0.00038441553,0.004955053,0.93998474,0.008341656,0.0011998783,0.039631862],"study_design_scores_gemma":[0.00059876643,0.007260492,0.0014414872,0.000059082624,0.000082371065,0.0010546931,0.000121697776,0.0035589936,0.96548,0.0010105842,0.019268967,0.00006286919],"about_ca_topic_score_codex":0.00051514636,"about_ca_topic_score_gemma":0.0009160514,"teacher_disagreement_score":0.0017162103,"about_ca_system_score_codex":0.0003057416,"about_ca_system_score_gemma":0.00029390614,"threshold_uncertainty_score":0.0057412386},"labels":[],"label_agreement":null},{"id":"W1983290738","doi":"10.1016/s0960-894x(00)00538-2","title":"Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx™)","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Rofecoxib; Chemistry; Glucuronidation; Cyclooxygenase; Prostaglandin-Endoperoxide Synthase; Enzyme inhibitor; Pharmacology; In vitro; Metabolite; COX-2 inhibitor; Biochemistry; Enzyme; Microsome; Medicine","score_opus":0.00594845695606713,"score_gpt":0.20130332352367006,"score_spread":0.19535486656760293,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1983290738","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9636345,0.00851355,0.017690048,0.00024791417,0.000108263135,0.0002758207,0.003522862,0.000166106,0.0058409595],"genre_scores_gemma":[0.9770562,0.004541614,0.010174072,0.00010818201,0.000043739212,0.00007203294,0.0036525135,0.00004483949,0.0043068],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999163,0.000012690654,0.0000075300145,0.000014742674,0.000020603013,0.000028106917],"domain_scores_gemma":[0.9999236,0.0000075632192,0.000022470089,0.000008838833,0.000015372625,0.000022074308],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012842486,0.0004976853,0.00025755272,0.00041857857,0.00022251732,0.0002096337,0.0002211725,0.00023866796,0.0017333035],"category_scores_gemma":[0.00014388413,0.00020783434,0.0003478588,0.000321227,0.00012573661,0.0003540841,0.0001891196,0.00041387774,0.0006232398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007213703,0.00018436556,0.00031351857,0.00011623167,0.000021708918,0.00029560234,0.00003827175,0.00034965822,0.9810941,0.00017301562,0.00015704562,0.016534952],"study_design_scores_gemma":[0.00007228411,0.001322261,0.0027135771,0.000009779875,0.000037001377,0.00045894398,0.000019224974,0.00033921088,0.98956746,0.000055756773,0.005391394,0.000013008912],"about_ca_topic_score_codex":0.0006954525,"about_ca_topic_score_gemma":0.0009301256,"teacher_disagreement_score":0.0017333035,"about_ca_system_score_codex":0.0001739152,"about_ca_system_score_gemma":0.0003671271,"threshold_uncertainty_score":0.005798459},"labels":[],"label_agreement":null},{"id":"W1983314501","doi":"10.1016/j.bmcl.2011.04.088","title":"Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":156,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Oxindole; Chemistry; Potency; Combinatorial chemistry; Stereochemistry; Drug discovery; High-throughput screening; Pharmacology; In vitro; Biochemistry; Catalysis","score_opus":0.025811350270177866,"score_gpt":0.22762341991313442,"score_spread":0.20181206964295656,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1983314501","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.894192,0.048662525,0.017046863,0.006577449,0.0007882783,0.00043870616,0.0011966915,0.0005160882,0.030581454],"genre_scores_gemma":[0.9520591,0.028847588,0.005671114,0.0021518716,0.00016106718,0.00009004358,0.0012288622,0.00003580689,0.009754537],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990857,0.00001796473,0.0000051453762,0.00001281116,0.000023442743,0.00003202471],"domain_scores_gemma":[0.99996424,0.0000065382123,0.0000058054316,0.0000023200755,0.000007835528,0.00001320074],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026949227,0.00028870607,0.0003624496,0.00026643238,0.00015259538,0.0005793601,0.0003862585,0.00048765022,0.0013913468],"category_scores_gemma":[0.00015553353,0.00014394437,0.00031545796,0.00011913349,0.00022797046,0.00030507715,0.0002535322,0.00076739956,0.000609374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015950435,0.0006057593,0.0013402228,0.00051621185,0.00013826031,0.0022693684,0.00015330431,0.0015291548,0.7913393,0.011528106,0.0076613943,0.1813238],"study_design_scores_gemma":[0.0041825417,0.01589319,0.0072342213,0.00024035618,0.0005033167,0.0103478,0.0002686458,0.010228162,0.8002478,0.0042435224,0.14649287,0.000117563955],"about_ca_topic_score_codex":0.00029020788,"about_ca_topic_score_gemma":0.0010028965,"teacher_disagreement_score":0.0013913468,"about_ca_system_score_codex":0.00032690418,"about_ca_system_score_gemma":0.0004096467,"threshold_uncertainty_score":0.0046545267},"labels":[],"label_agreement":null},{"id":"W1983462537","doi":"10.1016/j.bmcl.2014.04.045","title":"Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"OmegaChem (Canada); AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Pyridine; Ligand efficiency; Stereochemistry; Combinatorial chemistry; Scaffold; Ligand (biochemistry); Chemical synthesis; Series (stratigraphy); In vitro; Medicinal chemistry; Receptor; Biochemistry","score_opus":0.011080088716465425,"score_gpt":0.21271508030871228,"score_spread":0.20163499159224685,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1983462537","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8842991,0.037021976,0.04936412,0.0021059902,0.0007495113,0.00067928305,0.00088720385,0.00056678144,0.024326075],"genre_scores_gemma":[0.95311046,0.013839703,0.019452007,0.00084797986,0.00014406051,0.00024011698,0.00073218066,0.000041452204,0.011592042],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986076,0.000028941182,0.000007367234,0.000026356574,0.000037908034,0.000038610495],"domain_scores_gemma":[0.9999268,0.0000105932195,0.000015550486,0.000005784645,0.000017971757,0.000023319237],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003110126,0.00036881567,0.00035092267,0.00026401447,0.00020564336,0.00032386632,0.00072284706,0.0003813648,0.0017951834],"category_scores_gemma":[0.00028454047,0.00016383952,0.00027869418,0.00014377551,0.00022227835,0.00026999915,0.00031876264,0.00072560256,0.0005377439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002665694,0.00018166428,0.0002456418,0.0001882573,0.000026391102,0.00041491943,0.000101199184,0.00069080695,0.9659922,0.0026706678,0.0010708625,0.028150853],"study_design_scores_gemma":[0.0005023825,0.0060626413,0.003780899,0.00008170535,0.00014667744,0.002699041,0.000093218034,0.006637558,0.89272475,0.001056658,0.08614436,0.000070003494],"about_ca_topic_score_codex":0.00051917817,"about_ca_topic_score_gemma":0.0018634027,"teacher_disagreement_score":0.0017951834,"about_ca_system_score_codex":0.0003989185,"about_ca_system_score_gemma":0.00032329344,"threshold_uncertainty_score":0.006005466},"labels":[],"label_agreement":null},{"id":"W1983520570","doi":"10.1016/j.bmcl.2009.08.086","title":"First generation 5-vinyl-3-pyridinecarbonitrile PKCθ inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Protein kinase C; Selectivity; Enzyme inhibitor; Enzyme; Stereochemistry; Biochemistry; Combinatorial chemistry","score_opus":0.00982171233828072,"score_gpt":0.21785544133187304,"score_spread":0.20803372899359232,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1983520570","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6386846,0.15751001,0.06312437,0.00420979,0.0042215656,0.0011020518,0.0030508384,0.0025631804,0.1255336],"genre_scores_gemma":[0.8801409,0.052998513,0.00977759,0.0009132752,0.00035216342,0.00047014374,0.001608239,0.00009994324,0.053639304],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998254,0.000018642826,0.0000105577565,0.000027515838,0.000037083817,0.00008082527],"domain_scores_gemma":[0.99992883,0.000011412472,0.000018182913,0.000010604866,0.000009804924,0.000021160404],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003425303,0.00087387505,0.00044663137,0.00041509158,0.00025697262,0.0005176821,0.0007483039,0.00060985924,0.00585795],"category_scores_gemma":[0.00024547245,0.00028055153,0.00030179514,0.00025773523,0.00025025068,0.00047656882,0.00044490193,0.0013867842,0.002231266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002087265,0.0009391193,0.00058529724,0.0015073183,0.00013693351,0.0014814702,0.00025927043,0.0051735393,0.653637,0.019721882,0.017958399,0.29651263],"study_design_scores_gemma":[0.0012267929,0.004383995,0.0021154084,0.00014265145,0.00012702683,0.0025158764,0.00006333241,0.003229525,0.7515735,0.0020834475,0.23244826,0.00009005086],"about_ca_topic_score_codex":0.00081445556,"about_ca_topic_score_gemma":0.0016478758,"teacher_disagreement_score":0.00585795,"about_ca_system_score_codex":0.00091179495,"about_ca_system_score_gemma":0.00048659154,"threshold_uncertainty_score":0.019596756},"labels":[],"label_agreement":null},{"id":"W1984008590","doi":"10.1016/j.bmcl.2011.07.054","title":"Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Research Nova Scotia; Nova Scotia Health Research Foundation","keywords":"Trypanosoma brucei; Chemistry; GTP'; Biochemistry; Purine metabolism; ATP synthase; Purine; Antiprotozoal; Guanosine; Enzyme; In vitro","score_opus":0.0354617920191378,"score_gpt":0.2546273904941807,"score_spread":0.2191655984750429,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984008590","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99244153,0.0017038304,0.0014893883,0.00026058228,0.00006517397,0.000034307213,0.00025833675,0.000030759355,0.0037160234],"genre_scores_gemma":[0.99720544,0.0006386774,0.00042168092,0.000036409885,0.000012220536,0.000015776392,0.0003527342,0.00000637897,0.0013107547],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989057,0.000025098518,0.000007082394,0.000011817276,0.000025981264,0.000039431325],"domain_scores_gemma":[0.9999411,0.00002472701,0.000008866249,0.0000071284453,0.0000053554045,0.000012842868],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017074021,0.00026598267,0.00013575812,0.000108557884,0.00016011913,0.00018661628,0.00017892796,0.00034758347,0.0025812234],"category_scores_gemma":[0.00022800721,0.00008046463,0.00019164004,0.0001056656,0.00023458296,0.00012387581,0.0001672912,0.00045294254,0.00029238185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00062306726,0.000060032613,0.00011817184,0.00006917775,0.0000072640955,0.00014563967,0.000028780349,0.00016114509,0.9961266,0.00044523558,0.00014542538,0.0020695012],"study_design_scores_gemma":[0.00008223215,0.00075962796,0.0013746069,0.00000823749,0.000010137272,0.0003558219,0.000019762594,0.00090322364,0.9943539,0.00012513546,0.0020021894,0.000005122603],"about_ca_topic_score_codex":0.00087412365,"about_ca_topic_score_gemma":0.000955188,"teacher_disagreement_score":0.0025812234,"about_ca_system_score_codex":0.00020185421,"about_ca_system_score_gemma":0.00024087036,"threshold_uncertainty_score":0.0086349845},"labels":[],"label_agreement":null},{"id":"W1984109058","doi":"10.1016/s0960-894x(00)00346-2","title":"4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Therapure Biopharma (Canada)","funders":"","keywords":"Chemistry; Glutamic acid; Agonist; Pharmacology; Receptor; Glutamate receptor; AMPA receptor; Biochemistry; Stereochemistry; Amino acid; Medicine","score_opus":0.04208958669357008,"score_gpt":0.3492225250164096,"score_spread":0.3071329383228395,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984109058","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.979246,0.008489401,0.0022707952,0.0002691767,0.00011352757,0.000044488745,0.00029600263,0.000115998,0.009154568],"genre_scores_gemma":[0.9888332,0.0040625497,0.0018203153,0.00021150357,0.00003639698,0.000029635581,0.00033898535,0.0000145259855,0.0046528596],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999897,0.000026848616,0.0000125458755,0.000011661745,0.00001824128,0.00003368727],"domain_scores_gemma":[0.99995565,0.00000988702,0.0000144415435,0.00000547636,0.0000047490043,0.000009819879],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020321799,0.00040003902,0.0003121917,0.00012166423,0.00010070353,0.00017439295,0.00027363244,0.0002236762,0.0018753355],"category_scores_gemma":[0.00016237247,0.0001256163,0.00011274985,0.00009968249,0.00012690815,0.00022233983,0.00024110655,0.00046777347,0.000690303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0020152053,0.00007840724,0.00027961668,0.00013609622,0.00003194546,0.0003615842,0.00003777915,0.0003417555,0.9765704,0.00066179014,0.0004860504,0.018999478],"study_design_scores_gemma":[0.00065772946,0.0037371777,0.0027534533,0.000025532214,0.00008109116,0.0017228035,0.00008474211,0.0006799957,0.9735768,0.00032071318,0.016339332,0.000020685435],"about_ca_topic_score_codex":0.00021960218,"about_ca_topic_score_gemma":0.00086083135,"teacher_disagreement_score":0.0018753355,"about_ca_system_score_codex":0.00019749982,"about_ca_system_score_gemma":0.00017048464,"threshold_uncertainty_score":0.0062736273},"labels":[],"label_agreement":null},{"id":"W1984234311","doi":"10.1016/j.bmcl.2008.12.074","title":"Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Tetrazole; Chemistry; Moiety; Mutant; Reverse transcriptase; Stereochemistry; Aryl; Wild type; Ring (chemistry); Biochemistry; Organic chemistry; Polymerase chain reaction; Gene","score_opus":0.022501324469527358,"score_gpt":0.20184612592217296,"score_spread":0.1793448014526456,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984234311","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9961021,0.0010414746,0.0013848101,0.00010466711,0.000018240824,0.000016261412,0.00007603171,0.000029441599,0.0012269797],"genre_scores_gemma":[0.9976708,0.00034622368,0.00082775415,0.000026488888,0.0000037760722,0.000010166297,0.00010772402,0.0000100847,0.0009968613],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99971944,0.00009638672,0.00001496829,0.000032528085,0.00007473326,0.00006188165],"domain_scores_gemma":[0.99977094,0.000114892624,0.000031428717,0.000018741903,0.000042187585,0.000021733733],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034554215,0.00029248727,0.00032096557,0.00013205306,0.0002712213,0.0003492817,0.0005327206,0.0004710991,0.0013373463],"category_scores_gemma":[0.0005138492,0.00027561607,0.00023417064,0.00016807338,0.00028434792,0.00022205147,0.00011044518,0.00039899888,0.00041486073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003951704,0.000033223365,0.00022441358,0.000043234435,0.000013648605,0.00009814811,0.00004651587,0.0003254454,0.99736434,0.00023511164,0.00005185342,0.0011688649],"study_design_scores_gemma":[0.000031273103,0.0002789868,0.0012303753,0.0000054859024,0.000016743723,0.0002083348,0.000037134112,0.0029720368,0.99440247,0.00004814792,0.0007605193,0.000008524596],"about_ca_topic_score_codex":0.0025746601,"about_ca_topic_score_gemma":0.001706144,"teacher_disagreement_score":0.0025746601,"about_ca_system_score_codex":0.00042402276,"about_ca_system_score_gemma":0.0002761018,"threshold_uncertainty_score":0.0051193833},"labels":[],"label_agreement":null},{"id":"W1984739913","doi":"10.1016/j.bmcl.2005.05.116","title":"Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Valine; Caspase; Stereochemistry; Enzyme; Potency; Aspartic acid; Structure–activity relationship; Chemical synthesis; Caspase 3; Apoptosis; Biochemistry; Programmed cell death; Amino acid; In vitro","score_opus":0.005541250638181455,"score_gpt":0.23329440836861437,"score_spread":0.22775315773043292,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984739913","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99759406,0.0005371066,0.0005329004,0.0000645537,0.000012387976,0.000014650979,0.000098616714,0.00002565823,0.0011201092],"genre_scores_gemma":[0.99916506,0.00024316399,0.00018884735,0.000026530357,0.0000054949764,0.000005877101,0.00004051678,0.000005644175,0.0003188339],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986005,0.000051208295,0.000013779872,0.000014890445,0.000020152691,0.000039855513],"domain_scores_gemma":[0.9997917,0.000109925895,0.00003115446,0.000011990583,0.000017979271,0.00003725438],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004087626,0.00026481794,0.00024531755,0.00013487233,0.00017183137,0.00021750334,0.00029019822,0.00025122392,0.0034374455],"category_scores_gemma":[0.0004005068,0.00013525304,0.0001574076,0.00015457696,0.0003368393,0.00043543274,0.00022041379,0.00050050206,0.00033599674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0064714784,0.00011614766,0.0005314565,0.00010939632,0.000027661383,0.00030177337,0.00006688672,0.0014559423,0.9798942,0.0006843063,0.00019477449,0.010145787],"study_design_scores_gemma":[0.00027407298,0.002024269,0.0012568666,0.000008587294,0.000038208887,0.00021686274,0.000027993408,0.0014514122,0.9938014,0.00010185111,0.000784381,0.000014085209],"about_ca_topic_score_codex":0.0005639008,"about_ca_topic_score_gemma":0.00044069742,"teacher_disagreement_score":0.0034374455,"about_ca_system_score_codex":0.00019258488,"about_ca_system_score_gemma":0.00019414372,"threshold_uncertainty_score":0.0114994645},"labels":[],"label_agreement":null},{"id":"W1985442980","doi":"10.1016/j.bmcl.2004.06.035","title":"Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Benzofuran; Acrylamide; Stereochemistry; Potency; Enantiomer; Chemical synthesis; In vitro; Organic chemistry; Biochemistry","score_opus":0.008789118257350226,"score_gpt":0.21946899717479568,"score_spread":0.21067987891744544,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1985442980","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98609054,0.0018788644,0.007354753,0.00017852912,0.00008331365,0.00017290603,0.001189397,0.00015300872,0.0028986165],"genre_scores_gemma":[0.9817571,0.0014347684,0.009221314,0.00010954212,0.000059574286,0.00021375286,0.0022945153,0.000084875865,0.0048244684],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976367,0.000040140414,0.00003812441,0.00005433536,0.000046730383,0.00005700078],"domain_scores_gemma":[0.99969923,0.000066514214,0.00007236359,0.000043191485,0.000048693426,0.00007002577],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004696223,0.0005099708,0.00042512972,0.00025391928,0.00026326167,0.00029189387,0.00045007694,0.00033165497,0.002166858],"category_scores_gemma":[0.000422928,0.00030709535,0.00030818876,0.0002638899,0.0002599997,0.00041993885,0.00020790947,0.00054804474,0.00063101185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003221699,0.000055682714,0.000040185627,0.00006242291,0.000010067995,0.00006839757,0.00002951204,0.00022013449,0.9973224,0.00023637986,0.00007013271,0.0015624544],"study_design_scores_gemma":[0.0001070602,0.00044830723,0.00058620557,0.000005703599,0.000013403427,0.00009047698,0.000009607634,0.00038890127,0.99658525,0.000030756742,0.0017236271,0.000010653155],"about_ca_topic_score_codex":0.00078889634,"about_ca_topic_score_gemma":0.0009021741,"teacher_disagreement_score":0.002166858,"about_ca_system_score_codex":0.00034614388,"about_ca_system_score_gemma":0.00040638325,"threshold_uncertainty_score":0.0072488785},"labels":[],"label_agreement":null},{"id":"W1985561271","doi":"10.1016/j.bmcl.2007.02.011","title":"Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NeurAxon (Canada)","funders":"","keywords":"Nitric oxide synthase; Chemistry; Gene isoform; Nitric oxide; Enzyme; ATP synthase; Neuronal Nitric Oxide Synthase; Enzyme inhibitor; Inhibitory postsynaptic potential; Pharmacology; Biochemistry; Structure–activity relationship; In vitro; Stereochemistry; Neuroscience; Organic chemistry; Gene; Biology","score_opus":0.009468908703543147,"score_gpt":0.24453977453845369,"score_spread":0.23507086583491055,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1985561271","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9430238,0.028925177,0.011139943,0.00059153076,0.0004300023,0.00021632887,0.00049273245,0.00042689533,0.014753517],"genre_scores_gemma":[0.97850317,0.010923737,0.003288329,0.00020012734,0.00008519139,0.00008185926,0.0004151762,0.000022567143,0.006479882],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999292,0.000014319763,0.000004105546,0.000010410628,0.000014360722,0.000027713955],"domain_scores_gemma":[0.99996936,0.0000057058064,0.0000068919476,0.000002608778,0.000005530557,0.000009892408],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016829291,0.0003903779,0.0003751946,0.0002648424,0.00025062868,0.00022245495,0.0005427721,0.00033287803,0.0017545051],"category_scores_gemma":[0.00010488417,0.00015014934,0.00015573596,0.00026701475,0.00018505627,0.00018731582,0.00020458356,0.00043073035,0.00034090906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00079382176,0.00015333985,0.00032120864,0.00041544525,0.000035359397,0.0005281073,0.00011622583,0.00085329835,0.9605094,0.0021738317,0.0015829755,0.032516968],"study_design_scores_gemma":[0.0009024777,0.0051672566,0.0054005575,0.000053077965,0.00014934657,0.001990483,0.00007034216,0.0044345176,0.9347334,0.0005527566,0.046494935,0.000050878367],"about_ca_topic_score_codex":0.0010705251,"about_ca_topic_score_gemma":0.003749075,"teacher_disagreement_score":0.0017545051,"about_ca_system_score_codex":0.00041439375,"about_ca_system_score_gemma":0.00021401503,"threshold_uncertainty_score":0.0058693886},"labels":[],"label_agreement":null},{"id":"W1985585660","doi":"10.1016/j.bmcl.2013.10.061","title":"Inhibition of serine and proline racemases by substrate-product analogues","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Francis Xavier University; Dalhousie University","funders":"","keywords":"Proline; Chemistry; Serine; Stereochemistry; Substrate (aquarium); Product inhibition; Amino acid; Biochemistry; Bicyclic molecule; Enzyme; Substrate analog; Glycine; Non-competitive inhibition; Active site; Biology","score_opus":0.004697289926062869,"score_gpt":0.1957569727581229,"score_spread":0.19105968283206004,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1985585660","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99069667,0.0022706254,0.002907461,0.00010923362,0.000064962536,0.00007344244,0.00030826763,0.000102264086,0.0034670534],"genre_scores_gemma":[0.995609,0.0010327847,0.0014656388,0.000027412343,0.000016573646,0.000027677686,0.0003826431,0.000017939947,0.0014203527],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996828,0.00009040048,0.00004536787,0.000048788243,0.000047106245,0.00008561002],"domain_scores_gemma":[0.99975604,0.000096806456,0.000047716676,0.000031967953,0.000024782676,0.000042727454],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040489368,0.0006194486,0.000461528,0.0002581361,0.00017859286,0.00029596078,0.0004831375,0.0004456466,0.0022179624],"category_scores_gemma":[0.00040484607,0.00024799805,0.00035868754,0.0002525101,0.00023921793,0.00030043643,0.00023052804,0.000624525,0.00055732334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002456611,0.00014597447,0.00023579213,0.00013218254,0.00003262985,0.0003576984,0.00006840231,0.00068184483,0.99049836,0.00052598014,0.00016650645,0.004698064],"study_design_scores_gemma":[0.00005128756,0.0007713811,0.00029242184,0.0000029817427,0.000009316458,0.00015791232,0.000008876687,0.00038906807,0.99748635,0.000026318396,0.0007989263,0.0000051442325],"about_ca_topic_score_codex":0.00055208546,"about_ca_topic_score_gemma":0.00065469317,"teacher_disagreement_score":0.0022179624,"about_ca_system_score_codex":0.0002951664,"about_ca_system_score_gemma":0.00026509404,"threshold_uncertainty_score":0.007419765},"labels":[],"label_agreement":null},{"id":"W1985848981","doi":"10.1016/j.bmcl.2008.12.107","title":"Identification of a series of benzoxazoles as potent 5-HT6 ligands","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sulfur-Based Synthesis Techniques","field":"Chemistry","cited_by":59,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Identification (biology); Series (stratigraphy); Stereochemistry; Combinatorial chemistry","score_opus":0.006950984595697045,"score_gpt":0.22580735833379198,"score_spread":0.21885637373809494,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1985848981","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94981956,0.027540853,0.009376791,0.00084438856,0.00014784253,0.00036682782,0.001522163,0.00024144448,0.010140092],"genre_scores_gemma":[0.9671729,0.014880446,0.0065341657,0.0002866964,0.000058566962,0.0001447626,0.0019399412,0.000024219727,0.008958297],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998958,0.000025001658,0.000007684102,0.00001444123,0.000028489576,0.000028559325],"domain_scores_gemma":[0.999926,0.000013886216,0.000019640065,0.000007522142,0.000014873346,0.000018085737],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024149881,0.00039667555,0.00042253145,0.00028876305,0.0002429758,0.0003471108,0.0005601787,0.00033799149,0.0027117634],"category_scores_gemma":[0.0002707857,0.00019918408,0.00023576125,0.00025126294,0.00021505232,0.00024969442,0.00027883344,0.0007057593,0.00078762847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006403425,0.00019896771,0.00088569825,0.0002879563,0.000046001394,0.0003636793,0.00009217532,0.0010614775,0.9623132,0.0010537143,0.0009449371,0.032111954],"study_design_scores_gemma":[0.0005408251,0.006601605,0.007727463,0.00008105806,0.00015367601,0.001903462,0.000095043244,0.002794264,0.9452946,0.00039833735,0.03436042,0.000049233546],"about_ca_topic_score_codex":0.0006474751,"about_ca_topic_score_gemma":0.0030204928,"teacher_disagreement_score":0.0027117634,"about_ca_system_score_codex":0.00046477313,"about_ca_system_score_gemma":0.0002385492,"threshold_uncertainty_score":0.009071767},"labels":[],"label_agreement":null},{"id":"W1986042567","doi":"10.1016/j.bmcl.2009.03.132","title":"Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Methyltransferase; Stereochemistry; Substituent; Enzyme; Enzyme inhibitor; Alkylation; Biochemistry; Carboxylic acid; Methylation; Selectivity; DNA; Catalysis","score_opus":0.006268148701448749,"score_gpt":0.2338984643577967,"score_spread":0.22763031565634795,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986042567","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96651155,0.011996496,0.010011257,0.0002669359,0.00019187327,0.00013416915,0.00059498515,0.00027760805,0.010015296],"genre_scores_gemma":[0.98933345,0.0039883996,0.0030506877,0.00007407326,0.000023586039,0.00005244482,0.00031672494,0.000023318034,0.0031374076],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999014,0.000030729807,0.000008366937,0.000015582855,0.000019540807,0.000024394],"domain_scores_gemma":[0.9999404,0.000014367692,0.000014213268,0.000007831703,0.000008872198,0.000014441832],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017393958,0.0003441,0.0004522227,0.00018573596,0.00018958903,0.00031028286,0.0005200895,0.00035795037,0.0022021583],"category_scores_gemma":[0.00021788196,0.00017232508,0.00015041344,0.00024404729,0.00018597239,0.00027988604,0.00036595875,0.0005436751,0.0004843052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016541294,0.00016514024,0.00017660433,0.00038205768,0.00009004003,0.00035914435,0.00011045842,0.0046843844,0.965519,0.0024555179,0.00097004813,0.023433566],"study_design_scores_gemma":[0.00031944516,0.001811024,0.00040300918,0.000022178225,0.00007826556,0.00026182338,0.000042854997,0.00313848,0.97901046,0.00036816247,0.014509764,0.000034465316],"about_ca_topic_score_codex":0.0009688613,"about_ca_topic_score_gemma":0.0024260343,"teacher_disagreement_score":0.0022021583,"about_ca_system_score_codex":0.00038335007,"about_ca_system_score_gemma":0.00023937035,"threshold_uncertainty_score":0.0073669553},"labels":[],"label_agreement":null},{"id":"W1986296520","doi":"10.1016/j.bmcl.2009.07.026","title":"Synthesis of chiral fluorine-tagged reference standards for the 19F NMR-based stereochemical analysis of sulfoxides at trace analytical levels","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Molecular spectroscopy and chirality","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Canada; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Fluorine; Absolute configuration; Fluorine-19 NMR; Sulfoxide; Stereochemistry; Organic chemistry; Nuclear magnetic resonance spectroscopy","score_opus":0.02210495586424492,"score_gpt":0.28929107837750406,"score_spread":0.26718612251325913,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986296520","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.28894833,0.003945988,0.68179405,0.00060079485,0.0006493713,0.0023138034,0.006200645,0.0029543096,0.012592745],"genre_scores_gemma":[0.2729619,0.0048765703,0.6947728,0.00056560105,0.00013795242,0.0025231123,0.012166772,0.0006417681,0.011353443],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9979121,0.00041868706,0.00021674475,0.0003887741,0.00084880774,0.00021491369],"domain_scores_gemma":[0.99707615,0.0004314771,0.00041696738,0.0006470996,0.0012158147,0.00021253819],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0034655458,0.0013735265,0.0009894134,0.0024729313,0.0011509522,0.0009748789,0.0021058666,0.0014198789,0.0034093133],"category_scores_gemma":[0.004496275,0.0009624716,0.0005735994,0.0018122224,0.0010601574,0.00089377176,0.0006499676,0.0017272349,0.0026216889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002711966,0.00017888626,0.0002638825,0.00015946414,0.000027245682,0.00012650939,0.00015240892,0.00073198153,0.9727103,0.0023728712,0.00084876287,0.022156369],"study_design_scores_gemma":[0.000032732813,0.00021265072,0.00021111038,0.000020686894,0.000020948479,0.00012752395,0.000025516809,0.00109917,0.9923814,0.00038311293,0.00546559,0.0000195527],"about_ca_topic_score_codex":0.0013662428,"about_ca_topic_score_gemma":0.005361874,"teacher_disagreement_score":0.0034655458,"about_ca_system_score_codex":0.0014824083,"about_ca_system_score_gemma":0.0027240848,"threshold_uncertainty_score":0.018327773},"labels":[],"label_agreement":null},{"id":"W1986974478","doi":"10.1016/j.bmcl.2009.02.043","title":"Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure–activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Benzimidazole; Stereochemistry; Structure–activity relationship; Chemical synthesis; Receptor; Biological activity; Gonadotropin-releasing hormone; Gonadotropin-releasing hormone receptor; Hormone receptor; In vitro; Hormone; Small molecule; Molecule; Combinatorial chemistry; Endocrinology; Internal medicine; Biochemistry; Luteinizing hormone; Organic chemistry","score_opus":0.02293649914731572,"score_gpt":0.227075694028195,"score_spread":0.20413919488087928,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986974478","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9826124,0.005710156,0.0061402433,0.00020444466,0.000105620966,0.00014735459,0.00027542748,0.00017196358,0.0046324525],"genre_scores_gemma":[0.9896828,0.0031468985,0.0033414199,0.000105521096,0.00003197537,0.00006858986,0.0003533036,0.00001144325,0.00325802],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992716,0.000014217595,0.000004336163,0.0000131708375,0.0000183285,0.000022811533],"domain_scores_gemma":[0.99995744,0.000010535703,0.000012387731,0.0000035680132,0.0000035016926,0.000012647499],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632029,0.00024788716,0.00031013292,0.00013330733,0.0001013027,0.00016226938,0.00048160428,0.00024079319,0.0015329228],"category_scores_gemma":[0.00012990739,0.000167793,0.00017806794,0.000105145045,0.00014935712,0.00014163631,0.00012877975,0.000391026,0.0004302455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002995704,0.000099193116,0.000079321944,0.000066113666,0.000011458665,0.0000939396,0.000023137583,0.00064021966,0.99411327,0.0002810612,0.00014260806,0.0041501154],"study_design_scores_gemma":[0.00043357495,0.007207137,0.003445868,0.000012391657,0.0000698152,0.00054853247,0.000027949272,0.0040977243,0.9762572,0.0001224941,0.007743039,0.000034252036],"about_ca_topic_score_codex":0.0005712501,"about_ca_topic_score_gemma":0.0024468831,"teacher_disagreement_score":0.0015329228,"about_ca_system_score_codex":0.00021875226,"about_ca_system_score_gemma":0.00015278786,"threshold_uncertainty_score":0.0051280856},"labels":[],"label_agreement":null},{"id":"W1987213192","doi":"10.1016/j.bmcl.2009.01.075","title":"Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Benzimidazole; Chemistry; In vitro; Antibiotics; Mechanism of action; Antibacterial agent; Pharmacology; Drug; Antibacterial activity; Stereochemistry; Combinatorial chemistry; Chemical synthesis; Bacteria; Biochemistry; Organic chemistry; Medicine; Biology","score_opus":0.01578551715751678,"score_gpt":0.2370311161224778,"score_spread":0.22124559896496102,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1987213192","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97532463,0.014641403,0.0032680621,0.0002100676,0.00011662823,0.0001196621,0.0006769641,0.000079822144,0.005562677],"genre_scores_gemma":[0.9876052,0.0046472168,0.0036112517,0.00007847021,0.000041883082,0.0000426335,0.0010919924,0.000013926792,0.0028673501],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985814,0.000034699402,0.000016892438,0.000017811726,0.000037362675,0.000035042693],"domain_scores_gemma":[0.9999082,0.00001683394,0.000017389919,0.000011300674,0.000020714793,0.000025490177],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024488848,0.00025870942,0.00027088355,0.00022613598,0.00016976781,0.00016772599,0.0003387798,0.0002314835,0.0015308186],"category_scores_gemma":[0.00023579228,0.0001381484,0.00016849073,0.0002092379,0.00012623252,0.0001420812,0.00012652295,0.0003075369,0.0003809179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046551676,0.00010232036,0.00010490827,0.00010762196,0.00000948397,0.00012202798,0.00002740935,0.00031442018,0.9918196,0.00014335597,0.00020554484,0.006577758],"study_design_scores_gemma":[0.000085971,0.0019986616,0.0016506659,0.000012003989,0.000032089956,0.0003595003,0.000011873748,0.0005555275,0.98967886,0.00003086099,0.005573743,0.0000102835],"about_ca_topic_score_codex":0.0011970703,"about_ca_topic_score_gemma":0.0025643897,"teacher_disagreement_score":0.0015308186,"about_ca_system_score_codex":0.00023091873,"about_ca_system_score_gemma":0.00024969515,"threshold_uncertainty_score":0.005121112},"labels":[],"label_agreement":null},{"id":"W1987328650","doi":"10.1016/j.bmcl.2011.07.091","title":"Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Substituent; Steric effects; Pyrimidine; Amine gas treating; Stereochemistry; IC50; Butyrylcholinesterase; Potency; Cholinesterase; Ring (chemistry); Aché; Acetylcholinesterase; Enzyme; In vitro; Pharmacology; Biochemistry; Organic chemistry","score_opus":0.06770903664879738,"score_gpt":0.2826802974933259,"score_spread":0.21497126084452853,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1987328650","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94485736,0.021507045,0.020371258,0.00029317144,0.00022647275,0.00038034684,0.0005432007,0.00044672965,0.011374367],"genre_scores_gemma":[0.9751902,0.007141447,0.010068975,0.00010603603,0.000046671496,0.00019387831,0.0005214751,0.000035935296,0.006695378],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999,0.000022040507,0.00000773882,0.000020780944,0.00002089625,0.000028587701],"domain_scores_gemma":[0.9999429,0.000007925197,0.0000147069895,0.0000053606313,0.00001301071,0.000016169513],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031216728,0.0005242177,0.00043671054,0.00021091424,0.00017369463,0.0001998177,0.00065109506,0.0003903258,0.001480363],"category_scores_gemma":[0.00016935957,0.00024128132,0.00021049194,0.00011602838,0.00013464823,0.00033763755,0.00020647542,0.0004065725,0.00062701054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00063600956,0.0001681032,0.00011070698,0.00021600303,0.000022904229,0.00021764007,0.00005473289,0.00055664656,0.9782025,0.0005146809,0.00029927367,0.019000867],"study_design_scores_gemma":[0.00028572325,0.0028328232,0.0009452627,0.000015622774,0.000056891357,0.0006379961,0.000015726368,0.0019526618,0.98134995,0.000067618435,0.011818973,0.000020833297],"about_ca_topic_score_codex":0.00056775357,"about_ca_topic_score_gemma":0.0012401248,"teacher_disagreement_score":0.001480363,"about_ca_system_score_codex":0.00032632565,"about_ca_system_score_gemma":0.00024368014,"threshold_uncertainty_score":0.0049523115},"labels":[],"label_agreement":null},{"id":"W1988386715","doi":"10.1016/j.bmcl.2010.12.113","title":"Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y14","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Bioavailability; Pharmacokinetics; In vivo; Zwitterion; Drug; In vitro; Pharmacology; Drug discovery; Receptor; Biochemistry","score_opus":0.007914632339213554,"score_gpt":0.21803911892402297,"score_spread":0.21012448658480942,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1988386715","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7265917,0.01270615,0.19843334,0.0035936937,0.0015667289,0.0017876214,0.0020572376,0.001474022,0.051789597],"genre_scores_gemma":[0.933418,0.0057718065,0.040124472,0.00085870625,0.00012691345,0.000293798,0.0007485706,0.00011143786,0.01854633],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991393,0.000014567393,0.000008192526,0.000019857638,0.000018497127,0.000024970726],"domain_scores_gemma":[0.9999547,0.0000084258945,0.000008006889,0.000007463555,0.0000085511265,0.000012858167],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020975446,0.0005293276,0.00034030425,0.00029638462,0.00022868802,0.00047430667,0.00039452824,0.00049372524,0.0023909416],"category_scores_gemma":[0.00020154881,0.00020332866,0.00020874731,0.00016766424,0.00024429942,0.0004705265,0.00039212848,0.0008748178,0.001206489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003721621,0.00029356813,0.00016951705,0.0002633556,0.000047363363,0.000517855,0.0000734938,0.0009913926,0.93615335,0.009149602,0.0018018075,0.050166577],"study_design_scores_gemma":[0.00015147614,0.0017577524,0.00049657736,0.000017117178,0.000040485942,0.00094759295,0.000020922382,0.002191396,0.95321137,0.0010617671,0.040069826,0.000033763583],"about_ca_topic_score_codex":0.00029664524,"about_ca_topic_score_gemma":0.00077994744,"teacher_disagreement_score":0.0023909416,"about_ca_system_score_codex":0.00018754548,"about_ca_system_score_gemma":0.00038810552,"threshold_uncertainty_score":0.007998526},"labels":[],"label_agreement":null},{"id":"W1988564810","doi":"10.1016/j.bmcl.2012.01.005","title":"First enantioselective syntheses of the dopamine D1 and D2 receptor modulators, (+)- and (−)-govadine","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Chemistry; Enantioselective synthesis; Dopamine; Dopamine receptor D2; Homovanillic acid; Dopamine receptor; Schizophrenia (object-oriented programming); Antipsychotic; Yield (engineering); Receptor; Combinatorial chemistry; Biochemistry; Neuroscience; Psychology; Catalysis; Psychiatry","score_opus":0.04583225456850538,"score_gpt":0.32604674774759945,"score_spread":0.2802144931790941,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1988564810","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7495782,0.03136969,0.06031526,0.0017842659,0.0017194944,0.0010829646,0.004658943,0.0010376916,0.14845352],"genre_scores_gemma":[0.941607,0.014953772,0.021180503,0.0005899831,0.00020450992,0.0002310571,0.0012822117,0.00017278151,0.01977822],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997719,0.000040596253,0.000025105304,0.000032799933,0.000046185898,0.00008334244],"domain_scores_gemma":[0.99989915,0.000015572035,0.000020107998,0.000019897287,0.000017009965,0.00002822594],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003505034,0.0007956659,0.0005496717,0.0004249794,0.00048171074,0.00040391873,0.0010132703,0.0005774452,0.0034043675],"category_scores_gemma":[0.0004121238,0.0003568104,0.00052087783,0.00035326983,0.0003556608,0.00063838693,0.0007618785,0.0009177091,0.0014125945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00078909536,0.00049040216,0.0006249468,0.0021870006,0.00025048023,0.0027958588,0.0013321332,0.0033089493,0.8724858,0.022063805,0.008906247,0.08476526],"study_design_scores_gemma":[0.00028678137,0.0017048449,0.0020136882,0.00010698897,0.00013733045,0.0023605048,0.00027050573,0.0019000854,0.88263863,0.0029677753,0.10548993,0.00012293246],"about_ca_topic_score_codex":0.0013905884,"about_ca_topic_score_gemma":0.0033816309,"teacher_disagreement_score":0.0034043675,"about_ca_system_score_codex":0.0005084058,"about_ca_system_score_gemma":0.0008102873,"threshold_uncertainty_score":0.011388779},"labels":[],"label_agreement":null},{"id":"W1988816078","doi":"10.1016/s0960-894x(99)00648-4","title":"Synthesis and estrogenic activities of novel 7-thiosubstituted estratriene derivatives","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Thioether; Estrogen receptor; Estrogen; Luciferase; Chemical synthesis; Stereochemistry; Steroid; Side chain; In vitro; Biochemistry; Organic chemistry; Hormone; Endocrinology; Internal medicine; Transfection; Cancer","score_opus":0.005863846927797042,"score_gpt":0.20873446839608137,"score_spread":0.20287062146828433,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1988816078","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9764653,0.0068149692,0.0042749564,0.0003779485,0.00012886415,0.000056955727,0.00047739115,0.00009851753,0.01130521],"genre_scores_gemma":[0.9843535,0.00540909,0.0021389131,0.0001153093,0.000040628514,0.000035423334,0.0004858223,0.000016943464,0.0074044093],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993336,0.000011815099,0.000008322622,0.00000945546,0.000012863362,0.000024130584],"domain_scores_gemma":[0.99992764,0.000012345801,0.000017644146,0.000009816008,0.000011321497,0.000021270931],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017291284,0.00035667553,0.00022826451,0.0002497106,0.00023531994,0.00019691316,0.00042665258,0.00028950346,0.0036058414],"category_scores_gemma":[0.00014133021,0.00015308842,0.0002505625,0.00026240613,0.00022748759,0.00030757178,0.00023653601,0.00043693566,0.0007048425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043441978,0.0001205588,0.00017906098,0.00023130198,0.000026549433,0.0008158004,0.00012857956,0.00096694083,0.9842202,0.0016868582,0.00028379954,0.010905945],"study_design_scores_gemma":[0.000057429526,0.00141287,0.0011515442,0.00001721296,0.00003994366,0.0005139255,0.00005722309,0.0005594461,0.98731506,0.0002594294,0.0085924985,0.00002342454],"about_ca_topic_score_codex":0.00039097306,"about_ca_topic_score_gemma":0.00095181033,"teacher_disagreement_score":0.0036058414,"about_ca_system_score_codex":0.00023715498,"about_ca_system_score_gemma":0.000287269,"threshold_uncertainty_score":0.012062728},"labels":[],"label_agreement":null},{"id":"W1989016634","doi":"10.1016/j.bmcl.2010.01.008","title":"Structure–activity relationships of diphenylpiperazine N-type calcium channel inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Canada Research Chairs","keywords":"Chemistry; N-type calcium channel; Calcium channel; Calcium channel blocker; Neuropathic pain; Calcium; Pharmacology; Structure–activity relationship; Selectivity; T-type calcium channel; Voltage-dependent calcium channel; Stereochemistry; In vitro; Biochemistry; Organic chemistry","score_opus":0.020845157996385717,"score_gpt":0.25604561282367183,"score_spread":0.2352004548272861,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989016634","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97587425,0.016265033,0.0018761582,0.00027180562,0.00006359904,0.000074228126,0.000872594,0.0000913585,0.004610934],"genre_scores_gemma":[0.98718333,0.007932467,0.0010055478,0.00011198952,0.000027484655,0.000036823385,0.0011806639,0.000009635846,0.0025120517],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990225,0.000019726263,0.000008988156,0.000017005264,0.000020938869,0.000031051743],"domain_scores_gemma":[0.99988854,0.000041895397,0.00002661048,0.000005973069,0.000011630714,0.000025368274],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025572808,0.00028085048,0.00035637186,0.00028496832,0.00011937891,0.00027264727,0.0004181835,0.00023871369,0.0021278712],"category_scores_gemma":[0.0003482055,0.00019527657,0.00020410387,0.0002185686,0.00013484302,0.0002942336,0.00013288231,0.0005491325,0.00026977426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.005673384,0.0010813086,0.0013195869,0.00047312,0.00021789761,0.00037106764,0.000084365405,0.007909367,0.9235892,0.0013013965,0.00184852,0.05613081],"study_design_scores_gemma":[0.0031696316,0.0283868,0.019296994,0.00007477242,0.0008058358,0.0020751457,0.000067731875,0.02334076,0.90059894,0.00068130787,0.0214116,0.00009059085],"about_ca_topic_score_codex":0.0009657044,"about_ca_topic_score_gemma":0.0022492441,"teacher_disagreement_score":0.0021278712,"about_ca_system_score_codex":0.0003450385,"about_ca_system_score_gemma":0.00021100375,"threshold_uncertainty_score":0.0071184635},"labels":[],"label_agreement":null},{"id":"W1989148461","doi":"10.1016/j.bmcl.2012.08.018","title":"Potent and orally efficacious benzothiazole amides as TRPV1 antagonists","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Benzothiazole; Chemistry; Pharmacophore; TRPV1; Pharmacology; Metabolic stability; Stereochemistry; Combinatorial chemistry; Biochemistry; Receptor; In vitro; Transient receptor potential channel","score_opus":0.015938536745302035,"score_gpt":0.24147692404479992,"score_spread":0.22553838729949788,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989148461","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93037325,0.037173875,0.010417772,0.0010016495,0.0004320944,0.00027609427,0.0009120984,0.00035570687,0.019057384],"genre_scores_gemma":[0.9698232,0.017348731,0.0024217013,0.0002326968,0.00014472607,0.00008308273,0.0005286776,0.000031414907,0.009385699],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999206,0.000014093494,0.0000042045494,0.00000835368,0.000016258,0.000036568363],"domain_scores_gemma":[0.9999696,0.000005900666,0.0000075250173,0.0000026584166,0.000004019601,0.0000102412],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020908973,0.000363795,0.00037330916,0.0001835548,0.00017835735,0.00024406196,0.0003843771,0.00027308695,0.0033812562],"category_scores_gemma":[0.00014542289,0.0002057073,0.00014900604,0.00015542189,0.00021419693,0.00035070145,0.00025541568,0.0008766576,0.0006446412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013736719,0.00028720175,0.00013164815,0.00030383334,0.00002041595,0.00029262033,0.00010103751,0.0007021866,0.96338177,0.0013643454,0.0019703982,0.030070934],"study_design_scores_gemma":[0.0018661,0.014548809,0.005944606,0.000078345234,0.00017952037,0.0016406784,0.00012949148,0.003166569,0.91539514,0.00093808287,0.056037802,0.00007491798],"about_ca_topic_score_codex":0.0005140476,"about_ca_topic_score_gemma":0.002004675,"teacher_disagreement_score":0.0033812562,"about_ca_system_score_codex":0.00021381129,"about_ca_system_score_gemma":0.00022987551,"threshold_uncertainty_score":0.011311412},"labels":[],"label_agreement":null},{"id":"W1989156468","doi":"10.1016/j.bmcl.2008.02.051","title":"Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine–bombesin conjugate","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Bombesin; Conjugate; Chemistry; Peptide; Photodynamic therapy; Stereochemistry; Receptor; Biochemistry; Neuropeptide; Organic chemistry","score_opus":0.015444658903214194,"score_gpt":0.2652639147770715,"score_spread":0.2498192558738573,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989156468","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9890455,0.0016254222,0.0071251886,0.00015411446,0.000024570027,0.00008294726,0.000067619636,0.00007382606,0.0018008479],"genre_scores_gemma":[0.99224937,0.0009961528,0.0044410257,0.00003940512,0.0000065828954,0.000049525876,0.00008440165,0.000018290862,0.0021151353],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998882,0.000022970877,0.0000069319653,0.000025809322,0.000027817305,0.000028308634],"domain_scores_gemma":[0.99995184,0.000014823828,0.000010753169,0.0000072588596,0.0000060653574,0.000009225397],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033462007,0.000320185,0.0002805387,0.00016208582,0.00013297814,0.0002744034,0.00027813992,0.00031323725,0.0008012723],"category_scores_gemma":[0.00017212702,0.0002670229,0.00021283742,0.00016162237,0.00021660436,0.00030956045,0.00036085982,0.00041047783,0.00021750294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000678867,0.000020711755,0.00006928746,0.00004298047,0.0000057583243,0.000035960125,0.000022780652,0.00022027428,0.9977701,0.00014459985,0.000033393702,0.001566344],"study_design_scores_gemma":[0.00001876015,0.00017285043,0.00053897256,0.000001836913,0.0000144190935,0.00013513223,0.0000060847874,0.0009953867,0.99690175,0.0000151647555,0.001196328,0.0000033618644],"about_ca_topic_score_codex":0.0005682067,"about_ca_topic_score_gemma":0.00064463937,"teacher_disagreement_score":0.0008012723,"about_ca_system_score_codex":0.0004130912,"about_ca_system_score_gemma":0.00024317605,"threshold_uncertainty_score":0.0029972196},"labels":[],"label_agreement":null},{"id":"W1989236715","doi":"10.1016/j.bmcl.2013.09.064","title":"Dual isotope labeling: Conjugation of 32P-oligonucleotides with 18F-aryltrifluoroborate via copper(I) catalyzed cycloaddition","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Oligonucleotide; Bioconjugation; Cycloaddition; Conjugate; Conjugated system; Combinatorial chemistry; Azide; Oligonucleotide synthesis; Copper; Click chemistry; Polyacrylamide gel electrophoresis; Catalysis; Organic chemistry; Enzyme; Biochemistry; DNA; Polymer","score_opus":0.007299551121879654,"score_gpt":0.19922352141854405,"score_spread":0.1919239702966644,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989236715","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8691583,0.004119703,0.11159199,0.0005438132,0.00029580417,0.0002910212,0.00062460435,0.001322744,0.012051862],"genre_scores_gemma":[0.9402337,0.0018065642,0.04781049,0.00010788572,0.000067342364,0.00022930198,0.00043558233,0.00010554185,0.009203575],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99954295,0.00007480577,0.00002766932,0.00015166186,0.00008182387,0.00012111908],"domain_scores_gemma":[0.9998412,0.000034033354,0.000042609503,0.000026156666,0.000023164243,0.000032931533],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005798902,0.0007272526,0.00050458766,0.0003888089,0.00035238737,0.00052068377,0.0007419452,0.0007598049,0.0015369289],"category_scores_gemma":[0.00037956217,0.00053171895,0.00030716183,0.00028571236,0.00042111738,0.00045969442,0.00047113103,0.00072927604,0.0008402042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000107042266,0.000017724313,0.00004724771,0.000042662974,0.0000042131305,0.00009299399,0.000030447341,0.00007494008,0.99606675,0.00034180723,0.00011442831,0.0030598477],"study_design_scores_gemma":[0.000010328865,0.0000851303,0.000095305135,0.0000015460892,0.0000059458557,0.00012352857,0.0000036054907,0.00027207137,0.99761283,0.00002487084,0.0017589759,0.000005839133],"about_ca_topic_score_codex":0.00076053507,"about_ca_topic_score_gemma":0.0012712113,"teacher_disagreement_score":0.0015369289,"about_ca_system_score_codex":0.00068335125,"about_ca_system_score_gemma":0.00035880282,"threshold_uncertainty_score":0.0051415563},"labels":[],"label_agreement":null},{"id":"W1989559524","doi":"10.1016/j.bmcl.2010.02.099","title":"Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Gonadotropin-releasing hormone; Biological activity; Chemical synthesis; Receptor; Hormone; Gonadotropin; Gonadotropin-releasing hormone receptor; Peptide hormone; Endocrinology; Pharmacology; Internal medicine; In vitro; Luteinizing hormone; Biochemistry; Biology","score_opus":0.019425695485536517,"score_gpt":0.2526340097141212,"score_spread":0.23320831422858468,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989559524","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97625625,0.006751847,0.0065520206,0.00029325733,0.00009836165,0.00024803978,0.00049850415,0.00010472859,0.00919691],"genre_scores_gemma":[0.9855639,0.005177336,0.0034483343,0.00015886611,0.000042418284,0.00006467233,0.00049646065,0.000015641215,0.0050324085],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994314,0.000013584375,0.000005217412,0.000007514936,0.000010304401,0.000020284775],"domain_scores_gemma":[0.99995196,0.0000079475285,0.00001389357,0.0000057594584,0.0000072017674,0.000013287639],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016876198,0.00027210894,0.00021827246,0.0001265075,0.00013935183,0.00012354468,0.00028784224,0.00018046316,0.0028138729],"category_scores_gemma":[0.0001473459,0.00012649206,0.00016159957,0.000116549105,0.00012456246,0.00018673697,0.00013269998,0.00032438946,0.00039282086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00067998207,0.00017956663,0.00013330484,0.00022770488,0.000020845564,0.00035363674,0.000059473772,0.00089774246,0.98170877,0.00063175935,0.0003221484,0.014785118],"study_design_scores_gemma":[0.0004981032,0.010696954,0.0031498722,0.000033151617,0.00008604584,0.0010531163,0.000060208127,0.002280884,0.9653476,0.00019958235,0.016561417,0.000033086522],"about_ca_topic_score_codex":0.000355553,"about_ca_topic_score_gemma":0.0008314803,"teacher_disagreement_score":0.0028138729,"about_ca_system_score_codex":0.00013646182,"about_ca_system_score_gemma":0.00018628917,"threshold_uncertainty_score":0.009413362},"labels":[],"label_agreement":null},{"id":"W1989616545","doi":"10.1016/j.bmcl.2012.02.004","title":"Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS)","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NeurAxon (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Azepine; Chemistry; hERG; Nitric oxide synthase; Nitric oxide; In vivo; Pharmacology; In vitro; Stereochemistry; Biochemistry; Potassium channel; Biophysics","score_opus":0.014312999969449505,"score_gpt":0.25177879508249795,"score_spread":0.23746579511304844,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989616545","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95223427,0.01672544,0.011762749,0.00041460752,0.00039258032,0.0002102241,0.00158251,0.00035773916,0.016319837],"genre_scores_gemma":[0.9767288,0.007275299,0.0058162054,0.00026950293,0.00006520616,0.00010470766,0.0010690677,0.000023391507,0.008647842],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999424,0.000009359245,0.000003772875,0.0000126524,0.000012280189,0.000019443658],"domain_scores_gemma":[0.99997187,0.00000435303,0.0000078095145,0.0000024065635,0.000004157923,0.000009328582],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010132791,0.00027613342,0.00030125387,0.00014289627,0.00012606953,0.00018684313,0.00048276552,0.00017380233,0.0016861638],"category_scores_gemma":[0.00008883518,0.00010348153,0.000115207804,0.00011763124,0.00016438628,0.00020994875,0.00014282436,0.00042892055,0.0005298768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029451537,0.00013206244,0.00015197787,0.00014187052,0.00001215871,0.00013856322,0.00004464337,0.00033776046,0.98553735,0.0008714081,0.00060138135,0.011736393],"study_design_scores_gemma":[0.00037520114,0.002855703,0.0045251516,0.000021505064,0.00005711357,0.0010909665,0.000044482214,0.0022268794,0.96771204,0.00036424835,0.020699153,0.000027662709],"about_ca_topic_score_codex":0.00038007507,"about_ca_topic_score_gemma":0.0016867957,"teacher_disagreement_score":0.0016861638,"about_ca_system_score_codex":0.00028033764,"about_ca_system_score_gemma":0.00017614149,"threshold_uncertainty_score":0.005640745},"labels":[],"label_agreement":null},{"id":"W1989769800","doi":"10.1016/j.bmcl.2009.08.014","title":"Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Hydrazine (antidepressant); CXC chemokine receptors; Chemotaxis; Ene reaction; Chemokine receptor; Stereochemistry; Chemical synthesis; Receptor; Chemokine; In vitro; Biochemistry","score_opus":0.024135228896730067,"score_gpt":0.2740413730877557,"score_spread":0.24990614419102566,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1989769800","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95181704,0.01983559,0.014532386,0.0005369282,0.00028866928,0.00089207053,0.0011761673,0.00024620487,0.010674915],"genre_scores_gemma":[0.9668245,0.01180119,0.01063977,0.00025345062,0.000053613534,0.00029063443,0.0009805368,0.000028051685,0.009128275],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999006,0.000017605078,0.000008424001,0.000013825318,0.00002328831,0.000036214613],"domain_scores_gemma":[0.99995553,0.000004835788,0.000011511078,0.0000040145756,0.0000091600305,0.000014881858],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223078,0.00046832784,0.00043180046,0.0002353812,0.00016986365,0.0003270803,0.000460968,0.00023563742,0.0020172612],"category_scores_gemma":[0.00013811179,0.00023219439,0.0001900279,0.00017628801,0.00018556144,0.00020017907,0.00021127229,0.00040605018,0.0004856678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000701192,0.0002464489,0.00027314082,0.0003555041,0.000029758625,0.0003013652,0.000082392035,0.0020531241,0.9688465,0.0009384266,0.00067037134,0.02550176],"study_design_scores_gemma":[0.00094848993,0.0051252516,0.0025067818,0.000043287244,0.00011640613,0.0007301296,0.000057669142,0.002862115,0.9595878,0.00019498933,0.027777852,0.000049182498],"about_ca_topic_score_codex":0.0008193345,"about_ca_topic_score_gemma":0.0032754226,"teacher_disagreement_score":0.0020172612,"about_ca_system_score_codex":0.000369538,"about_ca_system_score_gemma":0.00036696703,"threshold_uncertainty_score":0.0067483783},"labels":[],"label_agreement":null},{"id":"W1990416739","doi":"10.1016/s0960-894x(03)00120-3","title":"Synthesis and biological activities of phthalocyanine–estradiol conjugates","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Porphyrin and Phthalocyanine Chemistry","field":"Materials Science","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Conjugate; Affinities; Binding affinities; In vitro; Stereochemistry; Phthalocyanine; Estrogen receptor; Chemical synthesis; Photosensitizer; Receptor; Combinatorial chemistry; Biochemistry; Organic chemistry; Cancer","score_opus":0.01629832351613526,"score_gpt":0.21853750248823448,"score_spread":0.20223917897209923,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1990416739","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9936733,0.0022994543,0.0017897865,0.0000910676,0.000029219536,0.000029363398,0.00020823664,0.000033690547,0.0018458909],"genre_scores_gemma":[0.9934762,0.0012532511,0.0013012085,0.000036273897,0.000015457405,0.00003080696,0.00045479898,0.000016291404,0.0034157091],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985206,0.00003427963,0.000014306932,0.000025864912,0.00003589207,0.000037616897],"domain_scores_gemma":[0.99985087,0.000072070136,0.000022339853,0.000018954073,0.000013134813,0.000022680468],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034571812,0.00027600944,0.00022100616,0.00017019098,0.00013871863,0.00022336184,0.0001810742,0.00025485668,0.0015376719],"category_scores_gemma":[0.00030687088,0.0001783218,0.000163322,0.00023491039,0.0002129523,0.00021516452,0.00015846055,0.00034280782,0.00024673576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006278374,0.000086409025,0.00031290008,0.00006337163,0.000011150812,0.00012903078,0.000042169584,0.00046830054,0.99335337,0.00032435215,0.000096370306,0.0044847736],"study_design_scores_gemma":[0.000022745153,0.00023332497,0.0005103798,0.0000014235325,0.0000083181685,0.000074897725,0.0000037960574,0.00016829505,0.9977641,0.000020548945,0.00119003,0.0000021421295],"about_ca_topic_score_codex":0.00025745403,"about_ca_topic_score_gemma":0.00026828554,"teacher_disagreement_score":0.0015376719,"about_ca_system_score_codex":0.00026228107,"about_ca_system_score_gemma":0.00017604731,"threshold_uncertainty_score":0.0051440597},"labels":[],"label_agreement":null},{"id":"W1990763534","doi":"10.1016/j.bmcl.2007.06.033","title":"A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières; College of the North Atlantic; Memorial University of Newfoundland","funders":"","keywords":"Cytotoxicity; Apoptosis; Cytotoxic T cell; Chemistry; Breast cancer; Cell cycle; Cell culture; Cell cycle checkpoint; Cancer research; Programmed cell death; Cancer cell; Cancer; Pharmacology; In vitro; Biochemistry; Internal medicine; Biology; Medicine","score_opus":0.00927604106208214,"score_gpt":0.2313051947236266,"score_spread":0.22202915366154446,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1990763534","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9424682,0.023373986,0.013260198,0.00043939738,0.00026134992,0.00068643043,0.0013298233,0.00046801832,0.017712524],"genre_scores_gemma":[0.9529923,0.016767722,0.012785384,0.00050578796,0.00009358207,0.0003682452,0.0018963584,0.00007582244,0.014514817],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992764,0.000010475706,0.000007119829,0.000013617057,0.000018614866,0.000022559247],"domain_scores_gemma":[0.9999454,0.0000071957884,0.000010022206,0.000007493033,0.000009944802,0.000020042111],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012440163,0.00036966908,0.0004178151,0.0003241511,0.00026431947,0.00025641045,0.0004395948,0.00025303377,0.001492241],"category_scores_gemma":[0.000099306206,0.00013824183,0.0001433253,0.00024516348,0.00017204187,0.00019651046,0.00023449441,0.00047032378,0.0003892282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006517076,0.0003941887,0.00039888592,0.00032551526,0.000032147887,0.0003949752,0.000105338615,0.0012215964,0.93576634,0.0012893213,0.0015650927,0.057854988],"study_design_scores_gemma":[0.00035022857,0.0038630937,0.0029171482,0.000031063035,0.00006260954,0.0015273994,0.00003157891,0.0012233537,0.94605434,0.00024326718,0.043672793,0.000023187282],"about_ca_topic_score_codex":0.000548474,"about_ca_topic_score_gemma":0.0019870289,"teacher_disagreement_score":0.001492241,"about_ca_system_score_codex":0.00028497184,"about_ca_system_score_gemma":0.0002901083,"threshold_uncertainty_score":0.004992008},"labels":[],"label_agreement":null},{"id":"W1991572741","doi":"10.1016/j.bmcl.2009.09.120","title":"Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"National Medical Research Council; National Health and Medical Research Council","keywords":"Tranilast; Chemistry; Albuminuria; Diabetic nephropathy; Pharmacology; Potency; Kidney; Diabetes mellitus; Fibrosis; Nephropathy; Toxicity; Endocrinology; Medicine; Internal medicine; Biochemistry; In vitro","score_opus":0.012406875938793397,"score_gpt":0.2661521732175066,"score_spread":0.2537452972787132,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1991572741","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99234605,0.0026079153,0.001931113,0.000083650804,0.000030128049,0.000078985686,0.00028074277,0.000060458282,0.002581004],"genre_scores_gemma":[0.99472827,0.0015094329,0.001906344,0.00002440994,0.000009882637,0.000019012075,0.000288341,0.0000137023235,0.0015006587],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999866,0.000027735392,0.000011684326,0.000021010717,0.0000364136,0.00003707224],"domain_scores_gemma":[0.9998995,0.00001807998,0.000020479936,0.000009481688,0.000028603861,0.000023841643],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020187558,0.00037390628,0.00024687225,0.00038703697,0.00020600465,0.00023360779,0.0002699091,0.00020449523,0.0015674303],"category_scores_gemma":[0.0002261597,0.00013039786,0.00025593076,0.00035093926,0.00016720877,0.00022174111,0.000115636816,0.0002898169,0.00019867082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00084544066,0.00016405668,0.00014837409,0.00010894409,0.000012660698,0.000088785906,0.000021483955,0.0006044475,0.99323964,0.000086033404,0.000047249494,0.004632841],"study_design_scores_gemma":[0.000030211679,0.00071128487,0.00059140794,0.0000037217087,0.000021322698,0.00003961408,0.000008613005,0.00036667357,0.99726284,0.000010547964,0.0009491398,0.000004673503],"about_ca_topic_score_codex":0.0017514286,"about_ca_topic_score_gemma":0.0028137967,"teacher_disagreement_score":0.0017514286,"about_ca_system_score_codex":0.00026642327,"about_ca_system_score_gemma":0.00030648054,"threshold_uncertainty_score":0.00524354},"labels":[],"label_agreement":null},{"id":"W1991804469","doi":"10.1016/j.bmcl.2012.05.077","title":"Development and evaluation of multifunctional agents for potential treatment of Alzheimer’s disease: Application to a pyrimidine-2,4-diamine template","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"University of Waterloo","keywords":"Chemistry; Pyrimidine; Diamine; IC50; Viability assay; Substituent; Small molecule; Stereochemistry; Cholinesterase; Biochemistry; Combinatorial chemistry; Pharmacology; In vitro; Organic chemistry; Medicine","score_opus":0.08019085515242827,"score_gpt":0.34107903779369647,"score_spread":0.26088818264126823,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1991804469","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97455037,0.008259718,0.01201421,0.00013309221,0.00005984501,0.00038254666,0.00026291332,0.000115468094,0.0042219036],"genre_scores_gemma":[0.9852191,0.002962137,0.009448788,0.0000434989,0.000016338898,0.00010379879,0.0002618121,0.00001366887,0.0019307319],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990547,0.00002062221,0.000008189239,0.00002272475,0.000019058536,0.000023839399],"domain_scores_gemma":[0.99992704,0.000015521835,0.000015739422,0.000009056387,0.0000119147,0.000020680382],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041388147,0.00026770247,0.0002997166,0.00018435516,0.00015505022,0.00025555308,0.00031099364,0.00040674486,0.0011189556],"category_scores_gemma":[0.00024832622,0.00016158985,0.00023269726,0.00011069549,0.00013828745,0.00019913662,0.00014732945,0.00027982335,0.0002579479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036802155,0.00013106466,0.000109816,0.0001590126,0.000012049115,0.00013603884,0.000052449246,0.0006459408,0.98796207,0.0002745959,0.000081651444,0.010067332],"study_design_scores_gemma":[0.00011379248,0.0030921458,0.00047600263,0.000009202509,0.00003732761,0.00023253792,0.000011303669,0.0013580649,0.98999083,0.00003958484,0.004630641,0.000008530424],"about_ca_topic_score_codex":0.0004787671,"about_ca_topic_score_gemma":0.0008344122,"teacher_disagreement_score":0.0011189556,"about_ca_system_score_codex":0.00029266076,"about_ca_system_score_gemma":0.00020731679,"threshold_uncertainty_score":0.003743291},"labels":[],"label_agreement":null},{"id":"W1992376164","doi":"10.1016/j.bmcl.2009.09.118","title":"Solid phase synthesis of acylglycine human metabolites","year":2009,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Solid-phase synthesis; Chemical synthesis; Combinatorial chemistry; Carboxylic acid; Glycine; Organic chemistry; Amino acid; Biochemistry; In vitro; Peptide","score_opus":0.010929971830290925,"score_gpt":0.30619430894245236,"score_spread":0.29526433711216143,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992376164","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.78004414,0.0058245356,0.16427828,0.0013148858,0.00068090326,0.001362028,0.011308652,0.0016412303,0.033545334],"genre_scores_gemma":[0.9421838,0.0032619147,0.037506197,0.0001976538,0.00004749761,0.00029596375,0.00438414,0.00011904071,0.012003777],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998441,0.000037875056,0.000013883581,0.000024161265,0.000035759425,0.000044307],"domain_scores_gemma":[0.9999064,0.000022494403,0.000014849499,0.000019291689,0.000014686523,0.000022209408],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019208276,0.00053521426,0.00028368557,0.0002528505,0.00022211796,0.00018209658,0.00030343156,0.00031453,0.002802896],"category_scores_gemma":[0.00017989655,0.00015921859,0.00027334795,0.00035545288,0.00015239415,0.00022335972,0.00029424485,0.00052635185,0.0018912741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007004807,0.00017034812,0.00019894661,0.00016103154,0.000039722025,0.0007070386,0.00008261666,0.001206166,0.9757488,0.0018033017,0.0011588832,0.018022759],"study_design_scores_gemma":[0.000049036036,0.0005488098,0.00023308604,0.000005814015,0.0000151600625,0.00018767915,0.000014489082,0.0004953669,0.98801374,0.00027629227,0.010151666,0.000008908452],"about_ca_topic_score_codex":0.00034099745,"about_ca_topic_score_gemma":0.00069115544,"teacher_disagreement_score":0.002802896,"about_ca_system_score_codex":0.0002507336,"about_ca_system_score_gemma":0.00047780355,"threshold_uncertainty_score":0.009376645},"labels":[],"label_agreement":null},{"id":"W1992625499","doi":"10.1016/j.bmcl.2009.04.126","title":"Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCθ inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Protein kinase C; IC50; Stereochemistry; Alkoxy group; Chemical synthesis; Enzyme; Pharmacology; In vitro; Biochemistry; Organic chemistry","score_opus":0.005604799123212336,"score_gpt":0.2198966893091637,"score_spread":0.21429189018595138,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992625499","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9471383,0.01607052,0.013498577,0.0005842574,0.0003163969,0.0005232961,0.0011009371,0.00048193536,0.020285744],"genre_scores_gemma":[0.9759335,0.0109852785,0.006687343,0.00014133356,0.000053651842,0.00015568221,0.0007527424,0.000057944904,0.0052325004],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996172,0.000073901545,0.00004173745,0.00005003615,0.000093204144,0.00012394357],"domain_scores_gemma":[0.99986315,0.000024370163,0.000040154708,0.00001723541,0.000027523201,0.000027483988],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005445422,0.0008995005,0.0005843009,0.00059536874,0.00031732753,0.00037265744,0.00076138024,0.00045990702,0.0038495811],"category_scores_gemma":[0.0003954798,0.00031602025,0.00041054844,0.00055638386,0.0002677469,0.00040374603,0.00038349937,0.00077638286,0.0011676764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002244507,0.0012541014,0.0005547029,0.0010910223,0.00012706226,0.0014280048,0.0001914067,0.014906564,0.90109766,0.0028296644,0.0018833028,0.07239195],"study_design_scores_gemma":[0.000652995,0.0045202062,0.0018383956,0.00008399644,0.00013951061,0.0007682192,0.00008883553,0.0041403626,0.96592796,0.0003016586,0.021471037,0.00006682929],"about_ca_topic_score_codex":0.0012473548,"about_ca_topic_score_gemma":0.0033886316,"teacher_disagreement_score":0.0038495811,"about_ca_system_score_codex":0.0005796551,"about_ca_system_score_gemma":0.0006664073,"threshold_uncertainty_score":0.01287818},"labels":[],"label_agreement":null},{"id":"W1992649197","doi":"10.1016/j.bmcl.2014.12.044","title":"Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"NS5A; Chemistry; Linker; Genotype; Potency; Stereochemistry; Combinatorial chemistry; Hepacivirus; In vitro; Biochemistry; Gene","score_opus":0.010520720966161929,"score_gpt":0.229339428054131,"score_spread":0.21881870708796905,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992649197","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9534818,0.024108443,0.0074756676,0.00069393433,0.00011596098,0.0005221717,0.0017515107,0.00019332665,0.0116571495],"genre_scores_gemma":[0.97209215,0.014114446,0.004259061,0.0002650375,0.000037309306,0.00012418292,0.0016161132,0.00001850979,0.007473242],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999341,0.00001032852,0.000003893052,0.000007898484,0.000019470088,0.000024269744],"domain_scores_gemma":[0.9999641,0.0000047139074,0.000009178245,0.0000037942493,0.0000074670293,0.000010668518],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931732,0.00039661222,0.00034988162,0.00032687737,0.00016063327,0.00027282542,0.00036328138,0.00024797462,0.002788031],"category_scores_gemma":[0.00020699129,0.00016190602,0.00028784855,0.00020914616,0.00016226273,0.00018200962,0.00018852923,0.00034694816,0.00048187497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015889849,0.0005074339,0.0012874485,0.0005034077,0.00008042165,0.00047346595,0.00015899875,0.0024231907,0.89273036,0.0015859993,0.003864514,0.094795726],"study_design_scores_gemma":[0.002338721,0.00955043,0.027382862,0.00014560229,0.00034031257,0.0027596473,0.00009198245,0.008912092,0.8883226,0.0005968202,0.059454132,0.000104767525],"about_ca_topic_score_codex":0.0022071684,"about_ca_topic_score_gemma":0.0073497253,"teacher_disagreement_score":0.002788031,"about_ca_system_score_codex":0.00045438632,"about_ca_system_score_gemma":0.00043347944,"threshold_uncertainty_score":0.009326935},"labels":[],"label_agreement":null},{"id":"W1992735974","doi":"10.1016/j.bmcl.2009.05.009","title":"Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Tumor necrosis factor alpha; Enzyme inhibitor; Tumor necrosis factor α; Kinase; Pharmacology; Cancer research; Enzyme; Biochemistry; Immunology; Biology","score_opus":0.006869828767458327,"score_gpt":0.2335110980094203,"score_spread":0.22664126924196198,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992735974","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98479396,0.006461017,0.005260362,0.00013110382,0.00011651121,0.000092090464,0.00046101675,0.00020171999,0.0024823935],"genre_scores_gemma":[0.9926029,0.002213125,0.001630959,0.000051435374,0.000031991392,0.000060798342,0.0006210172,0.000010433798,0.002777423],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999064,0.000020713707,0.0000056603235,0.000012690044,0.000021691245,0.000032830198],"domain_scores_gemma":[0.99996424,0.000008861197,0.000007644324,0.000005128942,0.000003746146,0.000010409603],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119403,0.0003527134,0.00023141043,0.00013509966,0.00009335071,0.00024787063,0.00015927083,0.00015807361,0.0010001212],"category_scores_gemma":[0.00013603491,0.00011603424,0.00015899572,0.00016081533,0.000081708204,0.00012023549,0.0001267577,0.0004687941,0.00028419803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018676731,0.0002654734,0.00027965952,0.00006269018,0.00002958483,0.00015515067,0.000024111365,0.0002322121,0.9874477,0.000106556035,0.00062878645,0.008900518],"study_design_scores_gemma":[0.0003012977,0.002458473,0.0027782386,0.000005464705,0.000054673197,0.0005720039,0.000011434109,0.0013570781,0.9891404,0.000027820908,0.0032882788,0.0000048932125],"about_ca_topic_score_codex":0.00040172818,"about_ca_topic_score_gemma":0.0009038088,"teacher_disagreement_score":0.0010001212,"about_ca_system_score_codex":0.00014661711,"about_ca_system_score_gemma":0.00019025235,"threshold_uncertainty_score":0.0033457875},"labels":[],"label_agreement":null},{"id":"W1992737764","doi":"10.1016/j.bmcl.2007.05.022","title":"Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Piperidine; Chemistry; Selectivity; Sulfone; Enzyme; Potency; In vitro; Chemical synthesis; Stereochemistry; Enzyme inhibitor; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.01107824804862521,"score_gpt":0.262837433067292,"score_spread":0.2517591850186668,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992737764","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.952,0.009734189,0.026112137,0.00042977137,0.00024353046,0.00053384353,0.00081670383,0.0003623735,0.009767545],"genre_scores_gemma":[0.98145837,0.0039378847,0.009978861,0.0001542652,0.00004249351,0.00016503368,0.0006313396,0.000024538465,0.0036073562],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999176,0.000016211257,0.000009996099,0.000013720395,0.000014990445,0.00002744494],"domain_scores_gemma":[0.99994266,0.000008528017,0.000018040868,0.000005814959,0.000009186324,0.000015808657],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022895331,0.00038996967,0.00041121413,0.00017553287,0.0001459597,0.00024347626,0.0004334565,0.00030894217,0.001813552],"category_scores_gemma":[0.00018840776,0.00022371819,0.00016963172,0.0001499915,0.00013845632,0.00025353752,0.00018499576,0.0005075606,0.000478341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00055780535,0.00014313683,0.00012124729,0.00024940044,0.000016620901,0.0004334391,0.00007474454,0.0017750573,0.97124106,0.0009690699,0.00041686947,0.024001464],"study_design_scores_gemma":[0.00039928476,0.0029122147,0.0007576273,0.000027288334,0.000057383062,0.00072634243,0.000026798096,0.0028081194,0.9754229,0.00018085654,0.01665745,0.00002366302],"about_ca_topic_score_codex":0.00021249961,"about_ca_topic_score_gemma":0.0005796515,"teacher_disagreement_score":0.001813552,"about_ca_system_score_codex":0.00022680839,"about_ca_system_score_gemma":0.00016150252,"threshold_uncertainty_score":0.006066978},"labels":[],"label_agreement":null},{"id":"W1992852834","doi":"10.1016/j.bmcl.2008.12.080","title":"Deconstructing estradiol: Removal of B-ring generates compounds which are potent and subtype-selective estrogen receptor agonists","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Chemistry; Estrogen receptor; Ring (chemistry); Estrogen; Steroid; Chemical synthesis; Stereochemistry; Carcinogen; Receptor; Structure–activity relationship; Hormone; Pharmacology; Internal medicine; Endocrinology; Biochemistry; Cancer; Breast cancer; In vitro; Organic chemistry; Biology; Medicine","score_opus":0.007867496243762862,"score_gpt":0.20403630675709356,"score_spread":0.19616881051333068,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992852834","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97004235,0.0041975616,0.011911235,0.0005950417,0.00017902328,0.00007239586,0.0005639004,0.00017989836,0.012258502],"genre_scores_gemma":[0.98424983,0.004129726,0.00364935,0.00035968827,0.000036650188,0.000027660817,0.00037031935,0.00004953873,0.0071271956],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995553,0.0000055354567,0.0000037576167,0.0000069063667,0.000009318186,0.000018921413],"domain_scores_gemma":[0.9999547,0.000008051179,0.00001224194,0.00000848768,0.000005015637,0.000011483218],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011036138,0.0002469391,0.00018882572,0.00014901259,0.00011903233,0.00023261187,0.00025967023,0.0002736113,0.0016908048],"category_scores_gemma":[0.00014850449,0.00015531908,0.00017641278,0.00012608817,0.00022871027,0.00030771227,0.0002394128,0.00049771584,0.000678753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046150168,0.000103367725,0.0003008059,0.000088022454,0.000018736935,0.00043926778,0.000057104353,0.00071041874,0.9754664,0.003154342,0.00048327935,0.018716725],"study_design_scores_gemma":[0.00007930496,0.000722895,0.0007552963,0.000010577796,0.000022102355,0.00046628586,0.000038086513,0.00043778674,0.97999763,0.0006595691,0.01679485,0.000015640455],"about_ca_topic_score_codex":0.00034823557,"about_ca_topic_score_gemma":0.0005008741,"teacher_disagreement_score":0.0016908048,"about_ca_system_score_codex":0.00010312808,"about_ca_system_score_gemma":0.00019887058,"threshold_uncertainty_score":0.005656302},"labels":[],"label_agreement":null},{"id":"W1992900731","doi":"10.1016/j.bmcl.2005.08.037","title":"Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): A radiolabelled glycogen synthase kinase-3β specific inhibitor for PET studies","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"University of Toronto","keywords":"Chemistry; Desmethyl; Biodistribution; GSK-3; Glycogen synthase; In vivo; Nitro; Lipophilicity; Ex vivo; Radiosynthesis; Urea; Stereochemistry; Kinase; Enzyme; Biochemistry; In vitro; Metabolite; Organic chemistry","score_opus":0.02757977608018368,"score_gpt":0.2784243444237818,"score_spread":0.2508445683435981,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992900731","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91452533,0.011327254,0.059167996,0.0004587507,0.00021030939,0.00084694737,0.0032654146,0.0007108781,0.00948717],"genre_scores_gemma":[0.91627264,0.007082762,0.05012001,0.00020670249,0.000075818716,0.0007462258,0.006488391,0.00030170352,0.01870576],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998287,0.00004061889,0.000012803981,0.000044430042,0.000026047857,0.000047416976],"domain_scores_gemma":[0.99978775,0.00005872892,0.000045251763,0.000030680054,0.0000306883,0.000046930203],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006579589,0.0008383939,0.00053152186,0.00030772632,0.00030925215,0.0003828457,0.0007778995,0.0007405141,0.0023250068],"category_scores_gemma":[0.00030193964,0.0005767112,0.0003136538,0.00030267256,0.00027835747,0.00043142398,0.00016786357,0.0007292799,0.0011382484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004100928,0.00006843417,0.000033851793,0.000076118034,0.000010875152,0.00008756421,0.000022627752,0.00027297548,0.99712175,0.00014373237,0.000120696255,0.0016312613],"study_design_scores_gemma":[0.00009225924,0.0007084776,0.0002653256,0.0000045999664,0.000047958176,0.00030660012,0.0000087385,0.000657934,0.9943045,0.00002497592,0.0035706784,0.000007897249],"about_ca_topic_score_codex":0.0012027238,"about_ca_topic_score_gemma":0.0016436137,"teacher_disagreement_score":0.0023250068,"about_ca_system_score_codex":0.00051256025,"about_ca_system_score_gemma":0.00035782842,"threshold_uncertainty_score":0.0077778697},"labels":[],"label_agreement":null},{"id":"W1993224162","doi":"10.1016/j.bmcl.2006.07.077","title":"Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Phosphodiester bond; Chemistry; Hydrolysis; Zinc; Polymer; Catalysis; Metalation; DNA; Phosphate; Stereochemistry; Polymer chemistry; Combinatorial chemistry; Organic chemistry; Biochemistry; RNA","score_opus":0.0035618122093533343,"score_gpt":0.19000429532209162,"score_spread":0.18644248311273828,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993224162","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9953237,0.00035298555,0.0023872051,0.000045665158,0.00003356887,0.000011168733,0.000038617494,0.00006628798,0.0017407107],"genre_scores_gemma":[0.9975069,0.0001716721,0.0009829451,0.000015566427,0.0000049087807,0.0000067174215,0.000027776581,0.0000090043295,0.0012745378],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999379,0.000006488757,0.000004317817,0.000016371114,0.000011967932,0.000023026854],"domain_scores_gemma":[0.99992585,0.000014391481,0.000023017334,0.000011030944,0.0000072767193,0.00001847663],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009942711,0.00028654357,0.00016872771,0.00012509394,0.00014044435,0.00019182617,0.00032983467,0.00025103812,0.0012731168],"category_scores_gemma":[0.00013713753,0.00014384229,0.00015135335,0.00012280859,0.00016911652,0.00021964363,0.00021137626,0.0002717268,0.00020972567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022084665,0.000019445506,0.0000846266,0.000045682937,0.0000049945957,0.00008214675,0.000026116306,0.00015234109,0.99638474,0.00039988806,0.000031462918,0.0025478208],"study_design_scores_gemma":[0.000012741854,0.000115084025,0.00022386068,0.0000013757357,0.000005877359,0.000037199687,0.000003908036,0.00033263306,0.99873155,0.000022215914,0.0005106224,0.0000030031756],"about_ca_topic_score_codex":0.00028520208,"about_ca_topic_score_gemma":0.00037198287,"teacher_disagreement_score":0.0012731168,"about_ca_system_score_codex":0.00017208535,"about_ca_system_score_gemma":0.000119543845,"threshold_uncertainty_score":0.00425905},"labels":[],"label_agreement":null},{"id":"W1993240362","doi":"10.1016/j.bmcl.2009.02.076","title":"Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Cytotoxicity; Stereochemistry; Chemical synthesis; In vitro; Biochemistry","score_opus":0.01079973757100211,"score_gpt":0.22256221725635178,"score_spread":0.21176247968534967,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993240362","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99678963,0.0006723399,0.0009937468,0.000030161682,0.0000055904025,0.000012885095,0.00016523575,0.000010407794,0.0013199403],"genre_scores_gemma":[0.9974727,0.00043619942,0.0007056457,0.0000133888925,0.0000033924136,0.000008422715,0.00024593406,0.000003693023,0.0011104769],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99997187,0.0000075456733,0.0000025660866,0.0000045904953,0.000006181896,0.0000071615495],"domain_scores_gemma":[0.99994755,0.000011275314,0.000011756998,0.0000084729645,0.000005874601,0.000015015962],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000080232705,0.00017912616,0.0000705603,0.000118179,0.00007106527,0.00010173882,0.00008836921,0.000101187914,0.000494768],"category_scores_gemma":[0.000085733795,0.000051441777,0.00010391276,0.00010935759,0.00011277318,0.00012339657,0.00007284565,0.0001709342,0.0001063537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024302298,0.000018872892,0.00018473867,0.000017753468,0.0000038813114,0.0001060875,0.00001859327,0.00026974536,0.9969271,0.00017546791,0.000022764272,0.00201195],"study_design_scores_gemma":[0.000016337368,0.00030779172,0.0016468174,0.0000022006598,0.000008499553,0.00012849526,0.000012750168,0.00025082353,0.9963134,0.00006515214,0.0012445498,0.0000030098622],"about_ca_topic_score_codex":0.00033190232,"about_ca_topic_score_gemma":0.00052078353,"teacher_disagreement_score":0.000494768,"about_ca_system_score_codex":0.00012215956,"about_ca_system_score_gemma":0.00012122232,"threshold_uncertainty_score":0.001655221},"labels":[],"label_agreement":null},{"id":"W1993340740","doi":"10.1016/j.bmcl.2007.07.079","title":"Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University; Acadia University; Université Sainte-Anne","funders":"National Cancer Institute; National Institutes of Natural Sciences","keywords":"Chemistry; Curcumin; In vitro; Stereochemistry; Cell culture; Biological activity; Chemical synthesis; Bioassay; Cancer cell lines; Cancer cell; Biochemistry; Cancer; Internal medicine","score_opus":0.01708982225445463,"score_gpt":0.2574302280560839,"score_spread":0.24034040580162927,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993340740","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9703931,0.009443861,0.008420538,0.00048563536,0.00017881906,0.00036591035,0.0005846294,0.00021079401,0.009916654],"genre_scores_gemma":[0.9815361,0.004079214,0.008569355,0.00013440184,0.000026781236,0.000154531,0.0005313141,0.000031151572,0.00493713],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994457,0.000009340808,0.000005631581,0.000012869519,0.000008699593,0.000018894862],"domain_scores_gemma":[0.9999299,0.0000119426395,0.000019234696,0.000011030441,0.00001079542,0.00001708262],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012401491,0.00028891367,0.00024098843,0.00019338973,0.00018324738,0.00019523785,0.0003947771,0.00022419693,0.0024935543],"category_scores_gemma":[0.00019393688,0.00016010112,0.00022514441,0.00013734757,0.0001995968,0.00020516098,0.00015829864,0.0004470122,0.00045603848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00070547615,0.00017587312,0.00014733186,0.00042100903,0.000022549426,0.0002579255,0.000067388944,0.0011638553,0.97243077,0.0009938633,0.0005318879,0.023081932],"study_design_scores_gemma":[0.0002067503,0.0017171402,0.00062657875,0.00002558047,0.00005084849,0.00036983754,0.000024298663,0.0010291694,0.979681,0.00014942708,0.016094813,0.00002456943],"about_ca_topic_score_codex":0.0007797606,"about_ca_topic_score_gemma":0.0018342816,"teacher_disagreement_score":0.0024935543,"about_ca_system_score_codex":0.0004296395,"about_ca_system_score_gemma":0.00036242022,"threshold_uncertainty_score":0.008341789},"labels":[],"label_agreement":null},{"id":"W1993467374","doi":"10.1016/j.bmcl.2009.12.023","title":"Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Partial agonist; Chemistry; Reuptake inhibitor; Norepinephrine transporter; Agonist; Norepinephrine; Reuptake; Pharmacology; Dopamine; Serotonin transporter; Transporter; Serotonin Agonist; Antidepressant; Serotonin; Receptor; Endocrinology; 5-HT receptor; Biochemistry; Medicine","score_opus":0.054054512507234205,"score_gpt":0.31070405707199644,"score_spread":0.25664954456476224,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993467374","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97891253,0.0065146782,0.0074545094,0.0002807801,0.00007792566,0.00031924053,0.0005877463,0.00008087893,0.0057715992],"genre_scores_gemma":[0.98684245,0.004658833,0.0047943364,0.00011071309,0.000025383728,0.00010735777,0.00043206158,0.000015516835,0.0030132532],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999074,0.000019798399,0.000010849869,0.000014396898,0.000015119234,0.0000324154],"domain_scores_gemma":[0.99994385,0.000008868566,0.000015003053,0.000006391304,0.000008877578,0.00001705164],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022607733,0.00033539618,0.00036337247,0.00024515527,0.0001914441,0.00020788885,0.0005200568,0.00028239298,0.0017732523],"category_scores_gemma":[0.0001791236,0.00024173631,0.00021963484,0.00018644074,0.0001598095,0.000259223,0.00019780135,0.00040522616,0.00038728927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016067532,0.00043911656,0.00036317296,0.0004129757,0.000047470945,0.0007716653,0.00014624535,0.0018001581,0.9564353,0.0015954014,0.0004556435,0.035926245],"study_design_scores_gemma":[0.000905806,0.012819726,0.0034855173,0.00005091664,0.00020530073,0.0011875796,0.00007122589,0.0033337316,0.962241,0.0002943042,0.015360932,0.000043995475],"about_ca_topic_score_codex":0.000626498,"about_ca_topic_score_gemma":0.0016116987,"teacher_disagreement_score":0.0017732523,"about_ca_system_score_codex":0.00022822472,"about_ca_system_score_gemma":0.00025946953,"threshold_uncertainty_score":0.0059320927},"labels":[],"label_agreement":null},{"id":"W1993658423","doi":"10.1016/j.bmcl.2007.04.052","title":"Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Small molecule; Potency; Molecule; Pyrimidine; Stereochemistry; Combinatorial chemistry; Diamine; Drug discovery; Renin inhibitor; Renin–angiotensin system; IC50; High-throughput screening; In vitro; Biochemistry; Organic chemistry","score_opus":0.022162153811076914,"score_gpt":0.23809396893611615,"score_spread":0.21593181512503923,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993658423","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92423356,0.030220173,0.030178513,0.0009289003,0.0003913764,0.00047320296,0.0009388541,0.0005355292,0.012100024],"genre_scores_gemma":[0.97398776,0.007464575,0.0119255185,0.00018923046,0.00008443625,0.000095154224,0.000807563,0.000029547626,0.005416342],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99975556,0.00007415146,0.00001398239,0.0000335179,0.000077091856,0.000045760655],"domain_scores_gemma":[0.9998634,0.000039232244,0.000023968836,0.000013375738,0.000024568311,0.000035455985],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00055793085,0.00039924413,0.00058324455,0.00039687642,0.0001534649,0.0006538031,0.00062251434,0.00047115638,0.0016128216],"category_scores_gemma":[0.0005256342,0.00028271304,0.00029228683,0.00016368463,0.00022554018,0.00026625642,0.00024964323,0.00075285975,0.00067088514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00083323126,0.00022977869,0.00048515765,0.00018880883,0.000042797237,0.00048813285,0.00006557016,0.0011165631,0.9646605,0.0011651554,0.00051978417,0.030204494],"study_design_scores_gemma":[0.00050497823,0.003595337,0.0023423377,0.000026614023,0.00009408748,0.0015692274,0.000033593104,0.004449646,0.96900463,0.00023879818,0.018112743,0.000027965832],"about_ca_topic_score_codex":0.00035770988,"about_ca_topic_score_gemma":0.0011099873,"teacher_disagreement_score":0.0016128216,"about_ca_system_score_codex":0.0005066468,"about_ca_system_score_gemma":0.00023040565,"threshold_uncertainty_score":0.0053954124},"labels":[],"label_agreement":null},{"id":"W1993857407","doi":"10.1016/j.bmcl.2007.02.031","title":"Synthesis and biological evaluation of novel analogues of dictyostatin","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institutes of Health; National Cancer Institute; Public Health Agency of Canada","keywords":"Chemistry; In vitro; Microtubule; Cell culture; Chemical synthesis; Cytotoxicity; Stereochemistry; Biological activity; Cancer cell lines; Combinatorial chemistry; Cell growth; Cancer cell; Biochemistry; Cancer; Cell biology","score_opus":0.06544543634468435,"score_gpt":0.34055084448830103,"score_spread":0.27510540814361667,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1993857407","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99017346,0.0040535205,0.0017303779,0.00013111212,0.00008576643,0.000157279,0.0006083064,0.000028094264,0.003032027],"genre_scores_gemma":[0.9915065,0.0024539935,0.0021412051,0.00007562588,0.000016664451,0.000049666152,0.0007421957,0.000008409137,0.0030057956],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999948,0.000007901051,0.0000058165983,0.000009419688,0.000011468367,0.000017410957],"domain_scores_gemma":[0.9999292,0.000011746886,0.00001605324,0.000006339871,0.000010577961,0.00002600247],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014881563,0.00021802721,0.00020142662,0.00010592153,0.00012049086,0.00017006218,0.00021865092,0.00021151981,0.001666449],"category_scores_gemma":[0.00013722255,0.0000993529,0.00015846311,0.00008300661,0.00016152623,0.00017497675,0.00014510113,0.00043269127,0.00026803758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010068737,0.00012995482,0.00014010868,0.00012294912,0.000012585019,0.00018250104,0.000025412062,0.0005908001,0.99303824,0.00019762485,0.00011860459,0.0044344603],"study_design_scores_gemma":[0.00038335557,0.0043037077,0.0012157499,0.000011109181,0.000036869355,0.00047797407,0.000029846922,0.0005039941,0.984306,0.00004725413,0.008674737,0.000009432278],"about_ca_topic_score_codex":0.00044413938,"about_ca_topic_score_gemma":0.00079785817,"teacher_disagreement_score":0.001666449,"about_ca_system_score_codex":0.00031164958,"about_ca_system_score_gemma":0.00019531178,"threshold_uncertainty_score":0.005574882},"labels":[],"label_agreement":null},{"id":"W1994040267","doi":"10.1016/j.bmcl.2009.12.101","title":"N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Allosteric regulation; ADME; NS5B; Hepatitis C virus; Drug discovery; Stereochemistry; Subgenomic mRNA; Enzyme; Biochemistry; Virology; In vitro; Virus; Hepacivirus; Genotype","score_opus":0.017549723585472965,"score_gpt":0.28900185914461807,"score_spread":0.2714521355591451,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994040267","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9754386,0.0063516432,0.008061306,0.00023920553,0.000078044824,0.00027537928,0.00035255155,0.00023376265,0.008969465],"genre_scores_gemma":[0.9858344,0.003319546,0.006803294,0.00012326536,0.000023731067,0.000075888376,0.0005004326,0.00003555043,0.0032838227],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978024,0.000046158584,0.000015731079,0.000033959142,0.00006787895,0.00005597],"domain_scores_gemma":[0.99988484,0.000024476134,0.000025439529,0.000012414647,0.000025784928,0.000027093647],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045185085,0.000510424,0.00044588928,0.00021229424,0.00024329178,0.00029406731,0.0006116078,0.00025431687,0.0020129],"category_scores_gemma":[0.00039674726,0.00022278015,0.0002747345,0.00019226655,0.00021187203,0.0002200954,0.00025348412,0.0005809369,0.00042714298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0026002137,0.0014086508,0.00093528494,0.0004891097,0.00007404773,0.0004967588,0.00016667493,0.012131904,0.8927367,0.0019571043,0.0017533902,0.085250184],"study_design_scores_gemma":[0.001277135,0.011985503,0.0030371917,0.00005474235,0.00015628606,0.0009546613,0.000076424665,0.019143546,0.9401418,0.00029622833,0.022785872,0.000090782145],"about_ca_topic_score_codex":0.0020983845,"about_ca_topic_score_gemma":0.0069239964,"teacher_disagreement_score":0.0020983845,"about_ca_system_score_codex":0.0005751517,"about_ca_system_score_gemma":0.0003614651,"threshold_uncertainty_score":0.0067338347},"labels":[],"label_agreement":null},{"id":"W1994232808","doi":"10.1016/j.bmcl.2013.02.110","title":"Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; NS5B; Polymerase; Virology; Nucleotidyltransferase; Nucleoside; Hepatitis C virus; Stereochemistry; Enzyme; Virus; Hepacivirus; Biochemistry; RNA; Gene; Biology","score_opus":0.014341510563070049,"score_gpt":0.25725311446013854,"score_spread":0.2429116038970685,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994232808","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9020019,0.031663787,0.030342733,0.00096017955,0.00070092984,0.001062978,0.0022962603,0.0012506094,0.02972062],"genre_scores_gemma":[0.9560955,0.011789196,0.01532351,0.00080421136,0.00006919122,0.00024444243,0.0018965302,0.000057527854,0.013719919],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990165,0.000012943258,0.0000061815263,0.000020155298,0.000025519172,0.000033534692],"domain_scores_gemma":[0.9999536,0.000005384077,0.000008498541,0.0000042657207,0.0000073370943,0.00002085938],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019653988,0.0006196189,0.00053837907,0.0003343592,0.000267069,0.0004713952,0.00049831095,0.0003273317,0.0028074954],"category_scores_gemma":[0.00020614319,0.0002531921,0.00027405174,0.00020402098,0.0001538102,0.00030239625,0.0004121631,0.0006879377,0.0006069691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012494691,0.00064072065,0.0010594571,0.00066268217,0.0001460045,0.0012936366,0.00018062431,0.0056577306,0.8365134,0.0032164012,0.0060079144,0.14337204],"study_design_scores_gemma":[0.0019859376,0.010755928,0.0062908293,0.00020064625,0.00032045264,0.0049735997,0.00012812049,0.01845105,0.8185259,0.001602624,0.13659708,0.00016783562],"about_ca_topic_score_codex":0.0006400354,"about_ca_topic_score_gemma":0.0030106667,"teacher_disagreement_score":0.0028074954,"about_ca_system_score_codex":0.00043145547,"about_ca_system_score_gemma":0.00035889843,"threshold_uncertainty_score":0.009392023},"labels":[],"label_agreement":null},{"id":"W1994622813","doi":"10.1016/j.bmcl.2011.01.138","title":"Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Pyrimidine; Combinatorial chemistry; Structure–activity relationship; Stereochemistry; In vitro; Biochemistry","score_opus":0.049022063335244226,"score_gpt":0.2705475632669111,"score_spread":0.22152549993166687,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994622813","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94685405,0.024102582,0.009265215,0.000764482,0.00030514982,0.00044314054,0.0011086536,0.00049604475,0.016660744],"genre_scores_gemma":[0.96861947,0.01223329,0.009157778,0.00021303132,0.000053240517,0.00015425353,0.0014714006,0.000046993056,0.008050402],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998609,0.000046281635,0.000009388411,0.000020173398,0.000033007807,0.000030169127],"domain_scores_gemma":[0.99994254,0.000010918843,0.000010709451,0.000006732706,0.000009275862,0.000019724088],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035200763,0.00041203306,0.000657638,0.00038311808,0.00025822816,0.0005320023,0.00068628654,0.0003600142,0.003225233],"category_scores_gemma":[0.00026287942,0.00028894728,0.00038720918,0.00020838696,0.00019280793,0.00028423572,0.00027912657,0.0007205558,0.0008060583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017239614,0.0005607005,0.0006038708,0.0005252168,0.00010781112,0.00046556903,0.00015649249,0.005653278,0.8948843,0.002986394,0.0019851655,0.09034726],"study_design_scores_gemma":[0.0027158642,0.015592337,0.00466629,0.00013299996,0.0003648527,0.002866121,0.00012639938,0.019629277,0.8572299,0.0009472715,0.09561026,0.00011843553],"about_ca_topic_score_codex":0.0007084554,"about_ca_topic_score_gemma":0.002786034,"teacher_disagreement_score":0.003225233,"about_ca_system_score_codex":0.00053021254,"about_ca_system_score_gemma":0.00035002106,"threshold_uncertainty_score":0.010789514},"labels":[],"label_agreement":null},{"id":"W1994741655","doi":"10.1016/j.bmcl.2014.11.048","title":"Radiosynthesis and ex vivo evaluation of [18F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science","keywords":"Chemistry; Radiosynthesis; Ex vivo; Biodistribution; In vivo; Positron emission tomography; Specific activity; Radiochemistry; Monoamine oxidase B; Monoamine oxidase A; Pet imaging; Stereochemistry; In vitro; Monoamine oxidase; Nuclear medicine; Biochemistry; Enzyme","score_opus":0.01846728072944001,"score_gpt":0.25995617892183454,"score_spread":0.24148889819239452,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994741655","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.966008,0.009593591,0.018632315,0.00028419748,0.00006779119,0.0001694619,0.0005107279,0.00021376665,0.004520141],"genre_scores_gemma":[0.98361105,0.00312379,0.008437802,0.000082426224,0.00003754374,0.00018652307,0.00069302984,0.00009876847,0.0037290584],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998318,0.000072719944,0.000006464038,0.000033809596,0.000015007653,0.000040163137],"domain_scores_gemma":[0.9998272,0.000074033676,0.000034803317,0.000025137026,0.000015681682,0.000023106266],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000722511,0.000746414,0.00035821478,0.00037106374,0.000275075,0.00045030506,0.0007498029,0.00080249645,0.0014239353],"category_scores_gemma":[0.00043376794,0.0006509592,0.0003168372,0.00029221884,0.00036166125,0.0005201991,0.00016965695,0.00078133855,0.0004296993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017743489,0.00019886049,0.00014187057,0.0000969518,0.000036228696,0.00014994066,0.00007836674,0.00053924206,0.9931479,0.00025638507,0.00014936664,0.0034305318],"study_design_scores_gemma":[0.00027184322,0.004126026,0.0018231199,0.000014919472,0.00020673506,0.0013739615,0.000060393395,0.0028861342,0.986159,0.00008172191,0.0029717684,0.0000242792],"about_ca_topic_score_codex":0.001999693,"about_ca_topic_score_gemma":0.0016283356,"teacher_disagreement_score":0.001999693,"about_ca_system_score_codex":0.00034703285,"about_ca_system_score_gemma":0.00043081306,"threshold_uncertainty_score":0.004763484},"labels":[],"label_agreement":null},{"id":"W1995107778","doi":"10.1016/j.bmcl.2008.04.012","title":"Potent triazolyl-proline-based inhibitors of HCV NS3 protease","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Tripeptide; Moiety; Triazole; Sulfonamide; Quinoline; Protease; NS3; Aryl; Combinatorial chemistry; Stereochemistry; Isostere; Sitagliptin; Peptidomimetic; Enzyme; Biochemistry; Peptide; Organic chemistry","score_opus":0.028543788771773538,"score_gpt":0.26451147256165786,"score_spread":0.2359676837898843,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1995107778","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95906776,0.014235337,0.01093423,0.00050083257,0.00025403322,0.00022365565,0.0010702851,0.0004910077,0.013222844],"genre_scores_gemma":[0.98316264,0.00600676,0.0032332346,0.00022859778,0.000040608935,0.000079407735,0.0008835257,0.000021394897,0.006343898],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998983,0.000017282828,0.000007856052,0.000010983152,0.000022163398,0.000043331012],"domain_scores_gemma":[0.9999436,0.000009925559,0.0000124025955,0.0000046739883,0.000008855708,0.000020596071],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023595305,0.00046286822,0.0003006814,0.0002671217,0.00015687358,0.00028163317,0.00040553187,0.00024404032,0.0016976601],"category_scores_gemma":[0.00013833558,0.00017187512,0.00018875425,0.00020137515,0.0001679883,0.0001886756,0.00021953706,0.0006217426,0.0005990812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010540402,0.00018978034,0.00018699905,0.00021423174,0.000033010914,0.0003475231,0.000061020655,0.0013947433,0.97457564,0.00066964125,0.001199466,0.020073907],"study_design_scores_gemma":[0.00078644144,0.003018786,0.0022521473,0.00002293461,0.000071705355,0.0012376845,0.000032872525,0.0033472758,0.9756349,0.00019997505,0.013363226,0.00003204196],"about_ca_topic_score_codex":0.00084923144,"about_ca_topic_score_gemma":0.002162004,"teacher_disagreement_score":0.0016976601,"about_ca_system_score_codex":0.0003455133,"about_ca_system_score_gemma":0.00021089593,"threshold_uncertainty_score":0.0056792498},"labels":[],"label_agreement":null},{"id":"W1996113346","doi":"10.1016/s0960-894x(00)00320-6","title":"6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Chemistry; 5-HT6 receptor; Pharmacology; Stereochemistry; Chemical synthesis; Receptor; In vitro; 5-HT receptor; Biochemistry; Serotonin","score_opus":0.012194870462298484,"score_gpt":0.23031561544152312,"score_spread":0.21812074497922465,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1996113346","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9448581,0.028029116,0.005661165,0.00049845345,0.00029235895,0.00015891262,0.00060803123,0.0003529279,0.01954087],"genre_scores_gemma":[0.9750888,0.011170536,0.004074469,0.00027640013,0.00011033701,0.00012711901,0.0007035138,0.000028274262,0.008420489],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998934,0.000019269044,0.000008180171,0.000010729176,0.000029524219,0.000038829956],"domain_scores_gemma":[0.9999597,0.000005101415,0.000011579854,0.000003425317,0.0000057595357,0.000014455271],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791263,0.00034230878,0.0004002059,0.0002470154,0.00014559188,0.00017997068,0.00052103697,0.0003322237,0.0019162355],"category_scores_gemma":[0.0001124875,0.00017201726,0.00016441653,0.0001696322,0.00015758013,0.00019710399,0.00017384342,0.0005924081,0.00069571927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000957481,0.00017650223,0.00018890291,0.0002869078,0.000027125585,0.0003820461,0.000084800726,0.0007504232,0.96546435,0.0014826418,0.0011259483,0.029072817],"study_design_scores_gemma":[0.0009094574,0.0076963957,0.0067294273,0.000049617647,0.00013145631,0.001857437,0.00007797439,0.0034136905,0.93706197,0.00033125706,0.04167923,0.00006212803],"about_ca_topic_score_codex":0.00050976255,"about_ca_topic_score_gemma":0.0025071274,"teacher_disagreement_score":0.0019162355,"about_ca_system_score_codex":0.00022630682,"about_ca_system_score_gemma":0.00021058247,"threshold_uncertainty_score":0.00641042},"labels":[],"label_agreement":null},{"id":"W1996218736","doi":"10.1016/j.bmcl.2010.01.047","title":"Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Absolute configuration; Diffraction; X-ray crystallography; Tubulin; Crystallography; X-ray; Stereochemistry; Optics; Microtubule; Physics","score_opus":0.008433103372112775,"score_gpt":0.24101274160230896,"score_spread":0.23257963823019617,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1996218736","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9671541,0.005591642,0.004340701,0.00030873457,0.0000617826,0.000044372828,0.0027555814,0.00011739226,0.01962561],"genre_scores_gemma":[0.9886071,0.0022253513,0.0020655915,0.00007943559,0.000010115671,0.00002272029,0.0017817485,0.000021909442,0.0051860074],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992394,0.000013045973,0.000005491368,0.000013668086,0.000019184094,0.000024704172],"domain_scores_gemma":[0.9999405,0.000008823832,0.000018498182,0.0000055012506,0.0000124764765,0.0000141939945],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008961736,0.00030093867,0.00019345152,0.0002554369,0.00035553862,0.00026362058,0.0005038252,0.00027005607,0.0054343967],"category_scores_gemma":[0.0001724306,0.00021562044,0.00013097559,0.00037437657,0.0002850243,0.00028160872,0.00013465658,0.0004629492,0.00073131104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022215273,0.00010952868,0.00079788564,0.00026599423,0.0000386502,0.000815581,0.00018823413,0.0050203307,0.96940863,0.0046223025,0.0019420887,0.014569167],"study_design_scores_gemma":[0.00012163551,0.0006979321,0.0033431211,0.000016529191,0.000049953884,0.00039620342,0.00011081718,0.002334713,0.9774679,0.0004740315,0.01494891,0.000038226233],"about_ca_topic_score_codex":0.0017529832,"about_ca_topic_score_gemma":0.002523549,"teacher_disagreement_score":0.0054343967,"about_ca_system_score_codex":0.00048727408,"about_ca_system_score_gemma":0.00042127538,"threshold_uncertainty_score":0.018179834},"labels":[],"label_agreement":null},{"id":"W1996470416","doi":"10.1016/j.bmcl.2013.09.102","title":"Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Potency; Anthranilic acid; NS5B; IC50; Replicon; Enzyme; Enzyme inhibitor; Stereochemistry; Biochemistry; Pharmacology; In vitro; Hepacivirus; Genotype","score_opus":0.008264789003227522,"score_gpt":0.22737335939679326,"score_spread":0.21910857039356574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1996470416","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96512866,0.006853021,0.014039885,0.0003125475,0.00019445921,0.00020730517,0.0016183892,0.000616931,0.011028848],"genre_scores_gemma":[0.9788182,0.0032020756,0.007916746,0.00011887514,0.000029394856,0.00007754401,0.0013192524,0.000045531855,0.008472301],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998319,0.000038936552,0.000012492909,0.000028518418,0.00004666156,0.000041512736],"domain_scores_gemma":[0.9999155,0.000026430385,0.000013570326,0.000010986378,0.000013635149,0.000019970517],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031335402,0.00056913163,0.00051538926,0.00024340871,0.00022884614,0.00028662416,0.00033967252,0.00031704083,0.002900251],"category_scores_gemma":[0.0002147325,0.00021128115,0.00022790614,0.00024177277,0.00020341921,0.00020832795,0.00020589547,0.000633528,0.0006185256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004358479,0.00012160375,0.00009238245,0.0001265257,0.0000129425725,0.000072747665,0.00004794014,0.0008544249,0.99027175,0.00017982653,0.00064236583,0.0071416297],"study_design_scores_gemma":[0.00009819751,0.0013991949,0.0006146582,0.000009816807,0.000024724986,0.00018376792,0.000014204607,0.0020216745,0.9917613,0.000055304256,0.0037966731,0.00002042154],"about_ca_topic_score_codex":0.0013626933,"about_ca_topic_score_gemma":0.0038552117,"teacher_disagreement_score":0.002900251,"about_ca_system_score_codex":0.00029419322,"about_ca_system_score_gemma":0.00026799666,"threshold_uncertainty_score":0.009702265},"labels":[],"label_agreement":null},{"id":"W1996548885","doi":"10.1016/j.bmcl.2014.09.014","title":"5-(4-((4-[18F]fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: A selective dual inhibitor for potential PET imaging of Trk/CSF-1R","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Alberta; McGill University","funders":"","keywords":"Chemistry; Pyrimidine; Diamine; Trk receptor; Dual (grammatical number); Stereochemistry; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor","score_opus":0.010272828473729217,"score_gpt":0.27355349985173727,"score_spread":0.26328067137800804,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1996548885","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90920174,0.027123343,0.039201617,0.0011625871,0.00040110998,0.00028438424,0.0014588598,0.0014486351,0.019717649],"genre_scores_gemma":[0.9751314,0.003267508,0.01602819,0.00015959813,0.00009140185,0.00011707133,0.00075919944,0.00006500757,0.0043806667],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999746,0.00006188187,0.000009869339,0.00005875723,0.00003197757,0.000091543436],"domain_scores_gemma":[0.9999187,0.000020489922,0.000021128693,0.0000075194985,0.00000750464,0.000024723935],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003923104,0.00065018074,0.00060582074,0.000358823,0.0003012553,0.00042061534,0.0011753791,0.00088501227,0.001548514],"category_scores_gemma":[0.00022024676,0.00037181002,0.00022124228,0.00025617663,0.0002713618,0.00042322624,0.0002731622,0.0008018165,0.0009849205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010429779,0.00010418878,0.00022757376,0.00020038261,0.000027261141,0.00027668808,0.00004909805,0.00048279174,0.98273265,0.0005919165,0.0009518218,0.013312661],"study_design_scores_gemma":[0.00029194163,0.0012795634,0.0015820055,0.000011369748,0.00006385498,0.0020867463,0.000016230344,0.0026762672,0.978093,0.00007664607,0.01379611,0.000026102816],"about_ca_topic_score_codex":0.0022567948,"about_ca_topic_score_gemma":0.0031245083,"teacher_disagreement_score":0.0022567948,"about_ca_system_score_codex":0.0009816797,"about_ca_system_score_gemma":0.0003961841,"threshold_uncertainty_score":0.0071225762},"labels":[],"label_agreement":null},{"id":"W1997032474","doi":"10.1016/j.bmcl.2012.01.130","title":"N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: Synthesis and biological evaluation","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Research Nova Scotia","keywords":"Chemistry; Substituent; Indole test; Stereochemistry; IC50; Active site; Enzyme; In vitro; Biochemistry","score_opus":0.017459112827444098,"score_gpt":0.2577277596563511,"score_spread":0.24026864682890697,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1997032474","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9559812,0.024318289,0.0060042157,0.00026342217,0.00020924899,0.00023325007,0.0006612928,0.00016928313,0.0121598765],"genre_scores_gemma":[0.97849816,0.011625243,0.0035283724,0.00011568998,0.00006112094,0.00006518693,0.00045670042,0.000013458896,0.005635995],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992955,0.000015002494,0.0000036227111,0.000007335826,0.000016969392,0.000027558046],"domain_scores_gemma":[0.9999591,0.0000058953397,0.000007749012,0.00000432289,0.000007831282,0.0000151105605],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002681738,0.00031272342,0.00022950585,0.00024613237,0.00019592355,0.00012686859,0.00035386728,0.0002449263,0.0016529316],"category_scores_gemma":[0.00011406342,0.00012751028,0.0002357653,0.00017657719,0.00015281948,0.00020390566,0.00013990249,0.00038027915,0.00035099714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021720782,0.0005359388,0.0003537565,0.0004033713,0.000033649598,0.0005011585,0.000111152665,0.0013718103,0.9552672,0.0012856374,0.0010986163,0.03686567],"study_design_scores_gemma":[0.00043230833,0.010586687,0.0035834222,0.0000412599,0.00011839398,0.00082180765,0.000055218745,0.0021880048,0.9631406,0.00019899927,0.018796274,0.000037084097],"about_ca_topic_score_codex":0.0010462162,"about_ca_topic_score_gemma":0.003373028,"teacher_disagreement_score":0.0016529316,"about_ca_system_score_codex":0.00021150507,"about_ca_system_score_gemma":0.00029521342,"threshold_uncertainty_score":0.0055295825},"labels":[],"label_agreement":null},{"id":"W1997258440","doi":"10.1016/j.bmcl.2011.06.091","title":"New substrate analogue furin inhibitors derived from 4-amidinobenzylamide","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Public Health Agency of Canada","keywords":"Furin; Chemistry; Stereochemistry; Peptidomimetic; Proprotein convertase; Amino acid; Chemical synthesis; Enzyme; Structure–activity relationship; Enzyme inhibitor; Biochemistry; In vitro; Peptide","score_opus":0.013984845416561947,"score_gpt":0.19113908031118998,"score_spread":0.17715423489462803,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1997258440","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9240927,0.016715992,0.03675322,0.00066284434,0.0003208676,0.00028676522,0.0008027369,0.00065013225,0.019714693],"genre_scores_gemma":[0.9780386,0.005545358,0.00897847,0.00024134188,0.000051275147,0.00012540165,0.0009244948,0.000046292233,0.006048775],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988556,0.000024828376,0.000007964163,0.000023621104,0.000022549284,0.000035513014],"domain_scores_gemma":[0.9999486,0.00000851764,0.00001691523,0.000004144374,0.0000072919042,0.000014464323],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018686111,0.00054765126,0.00045604957,0.00019656161,0.00015426993,0.00038272218,0.00046831355,0.00035464624,0.0010771161],"category_scores_gemma":[0.0001406451,0.00018227081,0.00015175856,0.00016703761,0.00019717994,0.0003506784,0.00022451997,0.0007144909,0.00046722867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046922706,0.00006104046,0.000119322714,0.000117027186,0.000013823584,0.00030441428,0.0000361777,0.0007620143,0.9841024,0.001719406,0.00047474366,0.011820433],"study_design_scores_gemma":[0.00018882488,0.0011510047,0.0007576246,0.000018912559,0.000032541877,0.00070323586,0.000014540532,0.0023045167,0.97461516,0.00026354837,0.019927485,0.000022617674],"about_ca_topic_score_codex":0.00047703966,"about_ca_topic_score_gemma":0.0006595665,"teacher_disagreement_score":0.0010771161,"about_ca_system_score_codex":0.0004933143,"about_ca_system_score_gemma":0.00019112162,"threshold_uncertainty_score":0.0036033392},"labels":[],"label_agreement":null},{"id":"W1997688092","doi":"10.1016/j.bmcl.2011.09.121","title":"PET imaging using 64Cu-labeled sulfophthalocyanines: Synthesis and biodistribution","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke","keywords":"Biodistribution; Chemistry; Pet imaging; Photodynamic therapy; Amphiphile; Positron emission tomography; Radiochemistry; Nuclear medicine; In vitro; Biochemistry; Organic chemistry","score_opus":0.015699331879290464,"score_gpt":0.18830818976309813,"score_spread":0.17260885788380767,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1997688092","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9537102,0.0031768347,0.038968094,0.00029625266,0.000028185808,0.00008800765,0.00022695944,0.00025216187,0.0032533063],"genre_scores_gemma":[0.9718979,0.001408663,0.02190689,0.00007929698,0.000012992231,0.00006259956,0.0003321523,0.00006737123,0.004232093],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999107,0.000026724296,0.000005146055,0.000022985792,0.0000132758705,0.000021236276],"domain_scores_gemma":[0.999895,0.00003652282,0.000021531023,0.000015409378,0.000016021753,0.000015586798],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039814343,0.0003130656,0.00027037732,0.00022392905,0.00019735035,0.0003632585,0.00026109646,0.0004627597,0.00041821002],"category_scores_gemma":[0.00031122204,0.00025968757,0.0001702728,0.00019349727,0.000302743,0.00041044416,0.00020978446,0.00032688424,0.00022918744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013120826,0.000023038914,0.0001564784,0.000043362863,0.000004826019,0.000064641914,0.000034892815,0.00034988992,0.99485576,0.00039493633,0.00007998487,0.0038609614],"study_design_scores_gemma":[0.000008387312,0.00011454834,0.00027816204,0.0000019607464,0.00000768274,0.000118829135,0.000008433028,0.001396098,0.9969632,0.00004813482,0.0010505529,0.0000039315937],"about_ca_topic_score_codex":0.0006000146,"about_ca_topic_score_gemma":0.00073143264,"teacher_disagreement_score":0.0006000146,"about_ca_system_score_codex":0.00041242878,"about_ca_system_score_gemma":0.00027472407,"threshold_uncertainty_score":0.0029924512},"labels":[],"label_agreement":null},{"id":"W1997780054","doi":"10.1016/s0960-894x(99)00652-6","title":"Novel Dmt-Tic dipeptide analogues as selective delta-opioid receptor antagonists","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Dipeptide; Stereochemistry; δ-opioid receptor; Affinities; Opioid receptor; Selectivity; Receptor; Opioid; Binding affinities; μ-opioid receptor; Chemical synthesis; Structure–activity relationship; Peptide; Biochemistry; In vitro","score_opus":0.015925716958936964,"score_gpt":0.23898186918444858,"score_spread":0.22305615222551162,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1997780054","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9457979,0.013133249,0.010549064,0.00050522224,0.00044310768,0.0004319732,0.0011455985,0.00022334156,0.027770495],"genre_scores_gemma":[0.979537,0.0075819064,0.004353908,0.00030641208,0.00007118884,0.00013547121,0.00076602295,0.000020109861,0.0072279507],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999474,0.000007911,0.00000427923,0.000008350549,0.000010389355,0.000021630738],"domain_scores_gemma":[0.9999739,0.0000030850774,0.0000052215296,0.0000021594487,0.0000036665701,0.000011963468],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011116006,0.00029543362,0.00030189357,0.00017652383,0.00015295623,0.00024575417,0.00044152347,0.00023986472,0.0033449603],"category_scores_gemma":[0.00011101187,0.00012924068,0.0001358564,0.0001672684,0.00012083719,0.00022502744,0.00021412486,0.0005401683,0.000691711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011761124,0.00023815127,0.00020453612,0.0004611559,0.000039234998,0.0006802102,0.000075483396,0.0012403028,0.9452809,0.0022460418,0.0014265877,0.046931226],"study_design_scores_gemma":[0.0010090077,0.0077347117,0.0022905949,0.000075564436,0.00013640815,0.0024964702,0.000064909065,0.0041802004,0.9265611,0.00050024915,0.054896086,0.000054737266],"about_ca_topic_score_codex":0.00035594657,"about_ca_topic_score_gemma":0.00094871846,"teacher_disagreement_score":0.0033449603,"about_ca_system_score_codex":0.00026708553,"about_ca_system_score_gemma":0.00014327353,"threshold_uncertainty_score":0.011189997},"labels":[],"label_agreement":null},{"id":"W1998660158","doi":"10.1016/j.bmcl.2005.09.049","title":"Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Celiac Association","keywords":"Tetrapeptide; Chemistry; Tripeptide; Dipeptide; Aldehyde; NS3; Dengue virus; Stereochemistry; Protease; Serine protease; Peptide; Enzyme inhibitor; Biochemistry; Enzyme; Dengue fever; Virology","score_opus":0.009731485689946457,"score_gpt":0.23823072176763677,"score_spread":0.22849923607769032,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1998660158","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9821147,0.011139646,0.0023877665,0.00012916952,0.000049040973,0.00009967646,0.00036444506,0.00004023734,0.0036753367],"genre_scores_gemma":[0.98651487,0.008400703,0.0014466316,0.0001303177,0.000025658679,0.0000341024,0.00058220106,0.000007924793,0.0028576148],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995744,0.000007782117,0.0000028161155,0.0000052412247,0.000009480049,0.000017181612],"domain_scores_gemma":[0.99997854,0.0000051761044,0.0000044061567,0.0000015893357,0.000003935805,0.000006374992],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016032277,0.00029520976,0.0002935578,0.00014155867,0.000077937664,0.000107439584,0.00020825626,0.00014052352,0.0012901059],"category_scores_gemma":[0.0000802158,0.00009817352,0.00023140605,0.000112392714,0.00008605061,0.00021718486,0.00010736523,0.00030570984,0.00020334049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013746979,0.0003054919,0.0002728558,0.0002479987,0.000042437445,0.0002503221,0.000055842316,0.003156721,0.97551006,0.00027563886,0.0003435262,0.018164366],"study_design_scores_gemma":[0.00064092246,0.011086167,0.004706564,0.000024648263,0.00010481322,0.0008245594,0.00004008905,0.0031594308,0.9698948,0.00012065838,0.009371317,0.00002591678],"about_ca_topic_score_codex":0.0005267097,"about_ca_topic_score_gemma":0.00083516067,"teacher_disagreement_score":0.0012901059,"about_ca_system_score_codex":0.000161848,"about_ca_system_score_gemma":0.00007992771,"threshold_uncertainty_score":0.004315853},"labels":[],"label_agreement":null},{"id":"W1999146464","doi":"10.1016/j.bmcl.2012.05.129","title":"Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Genome British Columbia","keywords":"DMT1; Chemistry; Potency; In vivo; Tricyclic; In vitro; Pharmacology; Transporter; Biochemistry; Stereochemistry","score_opus":0.009387893524567295,"score_gpt":0.23067188428894972,"score_spread":0.22128399076438243,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999146464","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9478664,0.022422614,0.013639807,0.0009035055,0.0002712588,0.00032518923,0.00095075736,0.00048432517,0.013136184],"genre_scores_gemma":[0.97843105,0.010133174,0.0050229006,0.00018145217,0.00004110124,0.00007448565,0.00074521464,0.00003548796,0.0053351424],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999343,0.000013859646,0.000004050706,0.000009833895,0.000016179973,0.000021703747],"domain_scores_gemma":[0.99994504,0.000010825244,0.000011116613,0.000005465397,0.000012302693,0.000015340473],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023044804,0.000383353,0.00035749798,0.00032516665,0.00018162961,0.0003180429,0.00040149328,0.00028367774,0.0017345613],"category_scores_gemma":[0.00022759498,0.00020227654,0.00022333373,0.00022691286,0.00014996405,0.00019993643,0.00027740267,0.00062972016,0.00037821507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00091462437,0.00019575952,0.0004745912,0.00029506392,0.000057520872,0.0003955862,0.00007875634,0.0021889054,0.9495899,0.0016516763,0.0015230058,0.042634603],"study_design_scores_gemma":[0.00039551707,0.0023508184,0.0016912887,0.00003628695,0.00009521059,0.00065499067,0.000033204342,0.0033209126,0.96255785,0.00036654502,0.02847495,0.000022437998],"about_ca_topic_score_codex":0.00064213044,"about_ca_topic_score_gemma":0.0023706767,"teacher_disagreement_score":0.0017345613,"about_ca_system_score_codex":0.00043245047,"about_ca_system_score_gemma":0.00021870575,"threshold_uncertainty_score":0.005802691},"labels":[],"label_agreement":null},{"id":"W1999219498","doi":"10.1016/j.bmcl.2008.01.061","title":"Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Free Radicals and Antioxidants","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Biotechnology Research Institute; National Research Council Canada","funders":"","keywords":"TBARS; Chemistry; Antioxidant; Lipid peroxidation; Thiobarbituric acid; Phenol; Alkoxy group; Phenols; Chemical synthesis; Inhibitory postsynaptic potential; Structure–activity relationship; Stereochemistry; Biochemistry; In vitro; Organic chemistry; Internal medicine","score_opus":0.011007329914602586,"score_gpt":0.19895110332893007,"score_spread":0.18794377341432747,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999219498","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98145604,0.00658015,0.004397571,0.00020329974,0.000112954105,0.00008455097,0.00037063414,0.00009851327,0.0066962834],"genre_scores_gemma":[0.9914038,0.0029079579,0.0020271537,0.000068811634,0.000031740936,0.000035553556,0.0004364519,0.0000138314435,0.0030747186],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989855,0.000017359396,0.0000112669895,0.000014634161,0.000017204013,0.000041007574],"domain_scores_gemma":[0.9998592,0.000022518454,0.00003234923,0.0000155558,0.0000315238,0.00003893219],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002640097,0.00052567176,0.00026324132,0.0004003469,0.00018758,0.00020358666,0.00043672055,0.0002701083,0.002285383],"category_scores_gemma":[0.0002245694,0.00013267327,0.0002776392,0.00024487262,0.0002376081,0.000339036,0.00020021516,0.00047793132,0.00035132217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047268101,0.00014232728,0.00017122996,0.00020983037,0.000018681316,0.00020993604,0.00009954891,0.00047027098,0.988303,0.001045234,0.00015469943,0.008702604],"study_design_scores_gemma":[0.00004808721,0.0007179522,0.0012123564,0.000012368901,0.000022270031,0.00010591114,0.000018734761,0.00023663421,0.9944311,0.00009862293,0.0030848957,0.000010950926],"about_ca_topic_score_codex":0.00077703234,"about_ca_topic_score_gemma":0.0010488994,"teacher_disagreement_score":0.002285383,"about_ca_system_score_codex":0.0002907734,"about_ca_system_score_gemma":0.00034878575,"threshold_uncertainty_score":0.0076453686},"labels":[],"label_agreement":null},{"id":"W1999286385","doi":"10.1016/j.bmcl.2009.03.113","title":"SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Moiety; Enzyme; Methyltransferase; DNMT1; Stereochemistry; Enzyme inhibitor; Biochemistry; DNA methyltransferase; Alkylation; Methylation; DNA","score_opus":0.011191607426975891,"score_gpt":0.2606035091084085,"score_spread":0.24941190168143262,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999286385","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9295542,0.024332983,0.010057367,0.0019348136,0.000683641,0.00010741172,0.00084157236,0.0003865201,0.032101408],"genre_scores_gemma":[0.9850647,0.0054589133,0.0019079435,0.00037952728,0.00012702415,0.000029073442,0.00050377974,0.000016046144,0.0065130126],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999095,0.000023847204,0.000007496803,0.00001237297,0.00001937603,0.000027306505],"domain_scores_gemma":[0.99991286,0.000026583986,0.000018440796,0.0000105441695,0.000015025139,0.00001651185],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021328739,0.00033906524,0.0003479182,0.00017450754,0.00021231713,0.00027910844,0.00033041407,0.0005083711,0.0033412694],"category_scores_gemma":[0.00022095874,0.00014528415,0.00026772494,0.00012442489,0.00020523377,0.00024448466,0.00017114247,0.0007409355,0.0009971173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024933238,0.0001660309,0.00041017536,0.00025509263,0.000045853467,0.00075068517,0.00004969734,0.0012919388,0.9744272,0.00085894443,0.0011074439,0.018143607],"study_design_scores_gemma":[0.00029079782,0.003168551,0.0013481614,0.000020653135,0.00011253975,0.0010447457,0.000049957882,0.002273451,0.9786431,0.0002702888,0.012762024,0.000015561358],"about_ca_topic_score_codex":0.00059087033,"about_ca_topic_score_gemma":0.00068049366,"teacher_disagreement_score":0.0033412694,"about_ca_system_score_codex":0.00018620942,"about_ca_system_score_gemma":0.00029377,"threshold_uncertainty_score":0.011177599},"labels":[],"label_agreement":null},{"id":"W1999390115","doi":"10.1016/j.bmcl.2012.12.089","title":"Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2′-quinazolines","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":52,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute for Liberal Studies","keywords":"Chemistry; Quinazoline; Stereochemistry; Sulfonyl; Ring (chemistry); Docking (animal); Indoline; Molecule; In vitro; Benzene; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.008521542327614528,"score_gpt":0.21570208252414455,"score_spread":0.20718054019653,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999390115","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85206926,0.020182725,0.09207219,0.00091920444,0.00041759355,0.001021164,0.0013536536,0.0010722709,0.03089196],"genre_scores_gemma":[0.97770226,0.0044284672,0.01270599,0.00017170764,0.00004096872,0.00021550214,0.0003409162,0.000028601104,0.004365529],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991393,0.000017655082,0.0000073709994,0.000016699434,0.000014817923,0.000029479921],"domain_scores_gemma":[0.9999542,0.000007380441,0.000013770122,0.0000048969487,0.000006987008,0.000012686464],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003057874,0.00037669644,0.00030529537,0.0002526924,0.00014635242,0.00016419985,0.00071180606,0.00031525682,0.0017163531],"category_scores_gemma":[0.00017714212,0.00017032832,0.00025011855,0.00019217876,0.00019348621,0.00021297425,0.00028566443,0.00041571487,0.00070290995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040784318,0.00032139156,0.00035992448,0.00056517514,0.000038170376,0.00090038637,0.00026657703,0.0040753856,0.93421316,0.006784276,0.0017405999,0.050327156],"study_design_scores_gemma":[0.0004950606,0.004821282,0.002830076,0.00007934306,0.00009209013,0.0015102867,0.00006968772,0.008694217,0.9357034,0.0010522446,0.044561677,0.00009061676],"about_ca_topic_score_codex":0.00030548548,"about_ca_topic_score_gemma":0.0007785967,"teacher_disagreement_score":0.0017163531,"about_ca_system_score_codex":0.0003006605,"about_ca_system_score_gemma":0.0003253412,"threshold_uncertainty_score":0.005741775},"labels":[],"label_agreement":null},{"id":"W1999534865","doi":"10.1016/j.bmcl.2004.12.076","title":"Electronic structure calculations on the thiazole-containing antibiotic thiostrepton: molecular mechanics, semi-empirical and ab initio analyses","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Thiostrepton; Chemistry; Ab initio; Molecular mechanics; Antibiotics; Computational chemistry; Thiazole; Peptide; Stereochemistry; Molecular dynamics; Biochemistry; Organic chemistry; Ribosome","score_opus":0.020120018850575752,"score_gpt":0.2790261294027774,"score_spread":0.25890611055220164,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999534865","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9716693,0.0006000922,0.008800231,0.0006913526,0.000056949488,0.000052007617,0.0005200962,0.00028073252,0.017329121],"genre_scores_gemma":[0.9914942,0.00025287337,0.0057310397,0.00011114059,0.000022321012,0.0001018643,0.0004010979,0.00007647028,0.0018090032],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9998323,0.000049289803,0.0000064137066,0.000008999596,0.00007106917,0.000031954358],"domain_scores_gemma":[0.9991924,0.00042823696,0.00006332732,0.00007464358,0.00018702578,0.00005438937],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045049484,0.0004969915,0.0011169253,0.0009394971,0.0012828887,0.00069214153,0.0013205243,0.0012676495,0.0039804378],"category_scores_gemma":[0.001252783,0.00036319013,0.0004654912,0.0014252505,0.0006123745,0.00047872486,0.00037227818,0.0006522114,0.00033265757],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002571702,0.00013194578,0.0019308341,0.00024537178,0.000052022362,0.00037300575,0.00008867245,0.9646681,0.0031898287,0.018146627,0.0025436564,0.008372775],"study_design_scores_gemma":[0.0000995491,0.00006580992,0.0009824773,0.000012738858,0.000013598142,0.000025055573,0.00004680484,0.9952093,0.00090082973,0.002319445,0.00031483232,0.000009661626],"about_ca_topic_score_codex":0.009141449,"about_ca_topic_score_gemma":0.012104547,"teacher_disagreement_score":0.009141449,"about_ca_system_score_codex":0.001041704,"about_ca_system_score_gemma":0.0012916323,"threshold_uncertainty_score":0.018176496},"labels":[],"label_agreement":null},{"id":"W1999562007","doi":"10.1016/j.bmcl.2010.07.076","title":"The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Drug discovery; Phosphodiesterase; Chemical synthesis; Enzyme inhibitor; Structure–activity relationship; Pharmacology; Enzyme; Biochemistry; Stereochemistry; In vitro","score_opus":0.00287464642112334,"score_gpt":0.19014449572006412,"score_spread":0.18726984929894078,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999562007","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.78003204,0.08775366,0.08662565,0.0028193474,0.0011297718,0.0008764051,0.0042179087,0.0009209662,0.035624247],"genre_scores_gemma":[0.9098122,0.04515282,0.02570024,0.0010952926,0.00012812004,0.00027200542,0.002678756,0.000065717424,0.015094733],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999237,0.00000886864,0.0000061585615,0.00001330626,0.000015913545,0.000031898333],"domain_scores_gemma":[0.9999627,0.0000055655464,0.000007757558,0.0000042505635,0.0000072183957,0.000012421511],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029790562,0.0004980132,0.0004782934,0.00031227982,0.00018450058,0.00041499364,0.00049951265,0.00030550882,0.0017180134],"category_scores_gemma":[0.00020512872,0.0002894822,0.00028759782,0.00022585952,0.00018105053,0.00029091426,0.00043360278,0.00078343763,0.00059064594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008626977,0.00036118706,0.00064194034,0.0007463229,0.00013900998,0.000791182,0.00016070418,0.005868731,0.7967842,0.009598456,0.0064864666,0.17755906],"study_design_scores_gemma":[0.0012432836,0.0033661514,0.0024515796,0.00011243004,0.00026780923,0.0017406581,0.00009044327,0.007391341,0.8374102,0.0030008676,0.14283858,0.00008652175],"about_ca_topic_score_codex":0.00064197875,"about_ca_topic_score_gemma":0.0019175437,"teacher_disagreement_score":0.0017180134,"about_ca_system_score_codex":0.00051379926,"about_ca_system_score_gemma":0.0003386663,"threshold_uncertainty_score":0.0057473183},"labels":[],"label_agreement":null},{"id":"W2000208080","doi":"10.1016/s0960-894x(02)00131-2","title":"Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ferrocene Chemistry and Applications","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Chemistry; Potency; Bicyclic molecule; Selectivity; Discovery and development of direct thrombin inhibitors; Lactam; Moiety; Thrombin; In vivo; Stereochemistry; Structure–activity relationship; Chemical synthesis; Pharmacology; In vitro; Combinatorial chemistry; Biochemistry; Immunology","score_opus":0.01286485036189901,"score_gpt":0.2031869981751875,"score_spread":0.1903221478132885,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2000208080","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8262899,0.08681295,0.028605597,0.0031309526,0.00087366154,0.000501566,0.0015574923,0.0012165124,0.051011316],"genre_scores_gemma":[0.95000106,0.018535571,0.008759413,0.0010691971,0.00017294707,0.0001437219,0.0010159488,0.000056023706,0.020246161],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998933,0.000015126362,0.000005070738,0.000014231738,0.00002590123,0.000046277575],"domain_scores_gemma":[0.9999652,0.000005205172,0.0000060593215,0.000003436244,0.000005740134,0.000014339807],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022455827,0.0003761463,0.0004839623,0.0002761653,0.00019716396,0.0003281948,0.00061421545,0.00032266992,0.0021546143],"category_scores_gemma":[0.00017263163,0.00015635359,0.000117508825,0.00018343984,0.00020443478,0.00025338697,0.00033838517,0.0006790807,0.0007188976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018109208,0.0003017483,0.00031068941,0.00045952408,0.000040213523,0.000658385,0.00017043813,0.0009345855,0.8635714,0.0029500115,0.007994349,0.12079764],"study_design_scores_gemma":[0.0013820648,0.0047606174,0.0023983496,0.000079771875,0.00011131116,0.0034676613,0.00007174921,0.0029748243,0.8483531,0.0009009521,0.1354289,0.0000706555],"about_ca_topic_score_codex":0.0005963234,"about_ca_topic_score_gemma":0.002143036,"teacher_disagreement_score":0.0021546143,"about_ca_system_score_codex":0.00048415287,"about_ca_system_score_gemma":0.00015591663,"threshold_uncertainty_score":0.00720793},"labels":[],"label_agreement":null},{"id":"W2001303638","doi":"10.1016/j.bmcl.2010.04.038","title":"Synthesis of neurotensin(8–13)–phosphopeptide heterodimers via click chemistry","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Phosphopeptide; Click chemistry; Neurotensin; Chemical synthesis; Stereochemistry; Combinatorial chemistry; Peptide; Biochemistry; In vitro; Neuropeptide; Receptor","score_opus":0.0036742603220406484,"score_gpt":0.1959554418642831,"score_spread":0.19228118154224244,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2001303638","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97275037,0.0010574275,0.0155421095,0.00019304312,0.0001392853,0.00021140401,0.0006333749,0.00021265405,0.009260376],"genre_scores_gemma":[0.9801995,0.0009419579,0.009891754,0.00012827637,0.000027992268,0.00015643088,0.0008819977,0.0000461137,0.0077259326],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999782,0.00003429835,0.000026037675,0.00004603079,0.00004501074,0.00006664334],"domain_scores_gemma":[0.999881,0.000017684022,0.000028478833,0.000012332046,0.0000120867435,0.000048455768],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041351453,0.00043141184,0.00032357834,0.00017717406,0.0002674336,0.00030927162,0.00031737745,0.0003283682,0.0033449794],"category_scores_gemma":[0.00020306904,0.0002773225,0.00026898016,0.00026531957,0.00013728708,0.0003686766,0.0003929819,0.00059221446,0.0010761239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023482624,0.000099446384,0.00018240663,0.00007939438,0.000022737911,0.00027507957,0.00006655371,0.00030874717,0.9933171,0.0009013075,0.0003415164,0.004170775],"study_design_scores_gemma":[0.00007226274,0.00035987727,0.00079136726,0.0000055198834,0.000023922077,0.0003777781,0.000027053084,0.0008693654,0.9896458,0.00009701616,0.0077150236,0.00001487286],"about_ca_topic_score_codex":0.00025848506,"about_ca_topic_score_gemma":0.00057594466,"teacher_disagreement_score":0.0033449794,"about_ca_system_score_codex":0.00031001173,"about_ca_system_score_gemma":0.00027896694,"threshold_uncertainty_score":0.011190057},"labels":[],"label_agreement":null},{"id":"W2001329222","doi":"10.1016/s0960-894x(00)00461-3","title":"Design and synthesis of a novel water soluble benzotetrazepinone","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Cancer Institute","keywords":"Chemistry; Ring (chemistry); Solubility; Chemical synthesis; Stereochemistry; Combinatorial chemistry; Biochemistry; Organic chemistry; In vitro","score_opus":0.01277678418087558,"score_gpt":0.2153928049865091,"score_spread":0.2026160208056335,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2001329222","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.831614,0.006490874,0.1312652,0.0010026301,0.00040657126,0.0012587262,0.0011924976,0.0010164267,0.025753085],"genre_scores_gemma":[0.91930485,0.0057913726,0.04270369,0.00031417375,0.00008641308,0.0003617772,0.0010832072,0.00009124168,0.030263226],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991,0.000012347514,0.0000072306507,0.000022601378,0.000018689816,0.000029044693],"domain_scores_gemma":[0.9999496,0.0000047063013,0.000014907253,0.0000041365756,0.000008150952,0.000018521527],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014753021,0.0003908283,0.00031768865,0.00017537345,0.00022315216,0.00027565207,0.00046930293,0.0002914409,0.0032656451],"category_scores_gemma":[0.0001148568,0.00019275371,0.00018908444,0.00019736013,0.00017949667,0.0004233501,0.00030048715,0.0004930405,0.0013738772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001535007,0.00011360901,0.00008326514,0.00027731952,0.000017075392,0.00026080714,0.000074845026,0.0013099703,0.97929823,0.0016791677,0.0004887022,0.016243504],"study_design_scores_gemma":[0.00014816591,0.0022947926,0.00046667963,0.000018456338,0.000037599937,0.0003301213,0.000033826025,0.002149545,0.9611936,0.00023148341,0.03306214,0.000033557953],"about_ca_topic_score_codex":0.0004915438,"about_ca_topic_score_gemma":0.000986754,"teacher_disagreement_score":0.0032656451,"about_ca_system_score_codex":0.0003450755,"about_ca_system_score_gemma":0.00043831667,"threshold_uncertainty_score":0.010924697},"labels":[],"label_agreement":null},{"id":"W2001432246","doi":"10.1016/s0960-894x(03)00670-x","title":"Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"NS5B; Chemistry; Polymerase; Hepatitis C virus; Enzyme; Nucleotidyltransferase; Virology; Stereochemistry; Structure–activity relationship; Biochemistry; In vitro; Hepacivirus; Virus; Biology; Gene","score_opus":0.03529683505108982,"score_gpt":0.2856685009022049,"score_spread":0.2503716658511151,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2001432246","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9559398,0.019353148,0.0066752527,0.0013315704,0.00020003474,0.00059747085,0.0010566,0.00014205773,0.0147040775],"genre_scores_gemma":[0.9626192,0.017237375,0.004564445,0.0006829211,0.0000922948,0.00018774581,0.0022335248,0.000025445954,0.0123570375],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991524,0.000021545344,0.000005265768,0.0000078626,0.00001597146,0.00003416948],"domain_scores_gemma":[0.99992216,0.000025351545,0.0000127409085,0.000004377913,0.00001413883,0.000021217773],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035166065,0.00048425532,0.0005426247,0.00016541428,0.00025999377,0.00033819006,0.00025407303,0.0002496342,0.0048146304],"category_scores_gemma":[0.00023877632,0.00017835836,0.0003818144,0.0001362469,0.00019174331,0.00032739635,0.00016373816,0.00060732674,0.0006708366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0042309463,0.001321039,0.0009376543,0.0008620244,0.00009851177,0.00081027974,0.00033709197,0.007497576,0.9366307,0.0020883004,0.0032128445,0.04197295],"study_design_scores_gemma":[0.005396406,0.035528675,0.0062527456,0.00015752595,0.00042910437,0.0029179615,0.00035124147,0.012946684,0.8787615,0.0013476409,0.05581528,0.00009528108],"about_ca_topic_score_codex":0.0013331369,"about_ca_topic_score_gemma":0.0035747562,"teacher_disagreement_score":0.0048146304,"about_ca_system_score_codex":0.00035022484,"about_ca_system_score_gemma":0.00039998544,"threshold_uncertainty_score":0.016106546},"labels":[],"label_agreement":null},{"id":"W2001476650","doi":"10.1016/j.bmcl.2006.10.014","title":"Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Sphingosine; Receptor; Sphingosine-1-phosphate; Sphingosine kinase; Biochemistry; Enantiomer; Phosphorylation; Kinase; Stereochemistry","score_opus":0.004517545076678728,"score_gpt":0.20719550486730004,"score_spread":0.2026779597906213,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2001476650","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9811024,0.005688957,0.005581416,0.00021263005,0.00008819379,0.000066933826,0.000365702,0.00007696399,0.006816775],"genre_scores_gemma":[0.9915036,0.0025171968,0.0024340407,0.00008632094,0.000023907995,0.00004856609,0.00025576467,0.000018979417,0.0031116183],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999125,0.00002161163,0.0000041252338,0.000015378848,0.000016519436,0.000029782921],"domain_scores_gemma":[0.99994767,0.00001647323,0.000013185435,0.0000066371767,0.00000406594,0.000011930875],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015911751,0.00028776733,0.00030530876,0.00016627216,0.00017641968,0.0002866526,0.00041953032,0.00033906478,0.0029167898],"category_scores_gemma":[0.00016038424,0.00014270523,0.00012359854,0.00020376398,0.0002268828,0.00040384656,0.00026659505,0.00058063376,0.00044196396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011313591,0.00007847607,0.0001102836,0.00013250501,0.000022073344,0.00030552497,0.00008614301,0.0024806573,0.98306113,0.0030021465,0.00038974886,0.009200048],"study_design_scores_gemma":[0.00019921904,0.0011880369,0.00053667853,0.000013604298,0.000035853456,0.00023404979,0.000035219557,0.0018251857,0.98477364,0.00049655227,0.010637384,0.000024665631],"about_ca_topic_score_codex":0.000460119,"about_ca_topic_score_gemma":0.0008560071,"teacher_disagreement_score":0.0029167898,"about_ca_system_score_codex":0.00036882795,"about_ca_system_score_gemma":0.00013153403,"threshold_uncertainty_score":0.009757638},"labels":[],"label_agreement":null},{"id":"W2001885206","doi":"10.1016/j.bmcl.2009.07.094","title":"2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Monsanto (Canada)","funders":"","keywords":"Chemistry; Stereochemistry; Enzyme; Amide; Enzyme inhibitor; Biochemistry; Combinatorial chemistry","score_opus":0.0028339863206067084,"score_gpt":0.19390508477996898,"score_spread":0.19107109845936227,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2001885206","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9586325,0.01865644,0.0062534204,0.00038958172,0.00020501789,0.00009445508,0.000791675,0.0003578366,0.01461905],"genre_scores_gemma":[0.98065543,0.008016836,0.0028800445,0.00010091518,0.0000485673,0.00003447503,0.00041504257,0.000025298474,0.0078235],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991024,0.000023784987,0.0000049687155,0.000010507041,0.000020725225,0.000029744564],"domain_scores_gemma":[0.99996495,0.000008528988,0.000005132537,0.0000039414085,0.0000047657036,0.000012649621],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018356075,0.00022189043,0.00030462607,0.00023657683,0.00014197665,0.0002539355,0.0002897006,0.00024958875,0.0015106839],"category_scores_gemma":[0.00012986368,0.00014387714,0.00010218597,0.00015954685,0.0001733675,0.00019795455,0.000118492586,0.00042326617,0.00047786342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011500824,0.00018994532,0.00020445297,0.0001370316,0.000018376286,0.00029302377,0.000059024074,0.0012318362,0.9794404,0.0012516322,0.0007147729,0.01530955],"study_design_scores_gemma":[0.00021333092,0.0013078795,0.0015043117,0.00000969355,0.000024132549,0.00035028884,0.00002099996,0.0019523836,0.98526704,0.00017682905,0.009162811,0.000010383725],"about_ca_topic_score_codex":0.00088032143,"about_ca_topic_score_gemma":0.0022384631,"teacher_disagreement_score":0.0015106839,"about_ca_system_score_codex":0.000353983,"about_ca_system_score_gemma":0.00019904207,"threshold_uncertainty_score":0.005053699},"labels":[],"label_agreement":null},{"id":"W2003344662","doi":"10.1016/j.bmcl.2010.10.107","title":"Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Pyridazine; Chemistry; Pharmacology; Distribution (mathematics); Pharmacokinetics; Tissue distribution; In vivo; Biochemistry; Stereochemistry; Internal medicine; Medicine; Biology","score_opus":0.010945645817903365,"score_gpt":0.2559257378438283,"score_spread":0.24498009202592497,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2003344662","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.991568,0.0037600852,0.0017601784,0.00025247366,0.00007158334,0.000096568634,0.0005701983,0.00012301568,0.0017977428],"genre_scores_gemma":[0.9950671,0.0019068443,0.000751976,0.000040292696,0.000026827365,0.00005101242,0.00065562903,0.000016042315,0.0014843544],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998159,0.000052150193,0.000012706285,0.000025207366,0.000036788882,0.000057219662],"domain_scores_gemma":[0.9998559,0.000037005426,0.000034618737,0.000019063844,0.000013803687,0.00003960112],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042374397,0.0004145666,0.0005804039,0.00034511896,0.00016705753,0.00036880965,0.00047615875,0.00038729978,0.0012033564],"category_scores_gemma":[0.00028243795,0.00021198316,0.00021601903,0.00026452544,0.00038657588,0.00037680057,0.00013304409,0.0011533552,0.00027811687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.009929816,0.001871066,0.00047983872,0.00016387913,0.00008399683,0.00013340203,0.00006726927,0.0025500928,0.9618216,0.00063655997,0.0008590061,0.021403372],"study_design_scores_gemma":[0.0019775317,0.03058748,0.0024833803,0.000011136798,0.00022265442,0.0002526976,0.000042918844,0.0027697887,0.95773727,0.0001500706,0.0037464127,0.000018661054],"about_ca_topic_score_codex":0.0013822938,"about_ca_topic_score_gemma":0.0025253068,"teacher_disagreement_score":0.0013822938,"about_ca_system_score_codex":0.00049847935,"about_ca_system_score_gemma":0.00036917374,"threshold_uncertainty_score":0.004025638},"labels":[],"label_agreement":null},{"id":"W2003855355","doi":"10.1016/j.bmcl.2011.06.006","title":"Evaluation of FKBP and DHFR based destabilizing domains in Saccharomyces cerevisiae","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"FKBP; Saccharomyces cerevisiae; Chemistry; Yeast; Mutant; In vivo; In vitro; Cell biology; Directed evolution; Biochemistry; Biology; Genetics; Gene","score_opus":0.04110595737420808,"score_gpt":0.2577830116315878,"score_spread":0.2166770542573797,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2003855355","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99600416,0.0009027933,0.0020795637,0.000058023088,0.000018277651,0.000026930951,0.00041791645,0.0000602006,0.00043213143],"genre_scores_gemma":[0.9954848,0.0005277994,0.002524959,0.000022962204,0.0000028142024,0.00001344944,0.0006461389,0.000021736778,0.00075519324],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998273,0.00004107048,0.00003272801,0.00002443298,0.000053051925,0.00002137749],"domain_scores_gemma":[0.9998493,0.000041214407,0.000033633565,0.00001696879,0.00003103254,0.000027826783],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031202656,0.00041789084,0.00031576367,0.00018067184,0.00023575428,0.0003650267,0.00033316124,0.00027870853,0.0008037818],"category_scores_gemma":[0.00028967272,0.00013396972,0.0002688781,0.00022207329,0.00017717811,0.00017684106,0.00017794795,0.00037517937,0.000246601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034265287,0.00006646704,0.0003190293,0.000057309808,0.0000190817,0.00010324584,0.000025202791,0.0012789731,0.99536884,0.00016536428,0.00004256219,0.002211263],"study_design_scores_gemma":[0.00001821189,0.00026574533,0.0005626381,0.0000041807007,0.00002858683,0.000104051294,0.000032409527,0.0013365663,0.99607396,0.00001535389,0.0015515689,0.0000067228343],"about_ca_topic_score_codex":0.0036013967,"about_ca_topic_score_gemma":0.0033551925,"teacher_disagreement_score":0.0036013967,"about_ca_system_score_codex":0.00056261255,"about_ca_system_score_gemma":0.0003017169,"threshold_uncertainty_score":0.007160902},"labels":[],"label_agreement":null},{"id":"W2004000887","doi":"10.1016/j.bmcl.2012.03.014","title":"Design and synthesis of potent, isoxazole-containing renin inhibitors","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Isoxazole; Chemical synthesis; Enzyme inhibitor; Renin–angiotensin system; Stereochemistry; Pharmacology; Combinatorial chemistry; In vitro; Biochemistry; Internal medicine","score_opus":0.020483177265968832,"score_gpt":0.23809009537938064,"score_spread":0.21760691811341182,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004000887","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7924154,0.041354053,0.12919217,0.0017385603,0.00094350916,0.0015424095,0.0019499698,0.000698075,0.030165894],"genre_scores_gemma":[0.92061085,0.022323975,0.04072786,0.000506066,0.00015473978,0.00035118146,0.0014652739,0.00006432104,0.01379576],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983907,0.000034150522,0.000020366166,0.000024940133,0.000039117152,0.000042287542],"domain_scores_gemma":[0.99991834,0.000011912039,0.000020708363,0.000009781677,0.00001710394,0.000022142545],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004508168,0.0005886366,0.0004844885,0.00032314242,0.00022665535,0.0005544085,0.0008895722,0.00036552447,0.0019322792],"category_scores_gemma":[0.00034752104,0.0003376334,0.0003310974,0.00025811442,0.0002601227,0.000590164,0.00034770925,0.0008749511,0.00085183827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000746961,0.0007031928,0.00036488695,0.00088365993,0.00010168599,0.0009205638,0.00028779104,0.0071263253,0.90257365,0.010301438,0.002660885,0.07332896],"study_design_scores_gemma":[0.0009881982,0.004995181,0.00091007445,0.00008438992,0.00015814045,0.0009782758,0.00008865961,0.0052208006,0.930799,0.0015812998,0.05412601,0.00007000368],"about_ca_topic_score_codex":0.0002627271,"about_ca_topic_score_gemma":0.0008982187,"teacher_disagreement_score":0.0019322792,"about_ca_system_score_codex":0.00039500053,"about_ca_system_score_gemma":0.0004203732,"threshold_uncertainty_score":0.0064641833},"labels":[],"label_agreement":null},{"id":"W2004458502","doi":"10.1016/s0960-894x(00)00217-1","title":"Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Phenazine; Internal ribosome entry site; Chemistry; In vitro; Reporter gene; Cytotoxicity; Virology; Gene; Molecular biology; Stereochemistry; Gene expression; Biochemistry; Biology; Messenger RNA; Translation (biology)","score_opus":0.006697027815310762,"score_gpt":0.23601071616722147,"score_spread":0.2293136883519107,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004458502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99532324,0.0011152657,0.0007505459,0.00012736252,0.0000332245,0.000039091432,0.00013907946,0.000051724954,0.0024205537],"genre_scores_gemma":[0.9968039,0.00065182016,0.0009857498,0.000065445776,0.000017407468,0.00003174557,0.00027525256,0.0000042746224,0.001164459],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994767,0.000014851471,0.00000329224,0.0000060504613,0.00000635351,0.000021805135],"domain_scores_gemma":[0.99996495,0.000009010451,0.000008687649,0.0000048541315,0.0000022298498,0.000010215185],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014518153,0.00021209131,0.00018709074,0.00009863209,0.0001349229,0.00012361657,0.00014811488,0.00020032839,0.001593828],"category_scores_gemma":[0.00011243162,0.0000999143,0.00018904045,0.000084420346,0.00016957561,0.00016376705,0.00013856239,0.00036544105,0.00025057278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0023236498,0.000141229,0.00020557262,0.000099362456,0.000018180992,0.00014935188,0.00003083338,0.00055387884,0.98958206,0.00043765537,0.0003251017,0.0061331433],"study_design_scores_gemma":[0.00063184905,0.0031119036,0.003769106,0.000010369623,0.00002638629,0.00050452614,0.000023320998,0.0022312,0.9862307,0.00012296671,0.0033277313,0.000010097063],"about_ca_topic_score_codex":0.0002229172,"about_ca_topic_score_gemma":0.0003844606,"teacher_disagreement_score":0.001593828,"about_ca_system_score_codex":0.00014197841,"about_ca_system_score_gemma":0.00010502118,"threshold_uncertainty_score":0.005331874},"labels":[],"label_agreement":null},{"id":"W2004577260","doi":"10.1016/j.bmcl.2014.07.080","title":"Identification of cytidine 2′,3′-cyclic monophosphate and uridine 2′,3′-cyclic monophosphate in Pseudomonas fluorescens pfo-1 culture","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"","keywords":"Pseudomonas fluorescens; Chemistry; Cytidine; Uridine; Extracellular; Intracellular; Biochemistry; Nucleotide salvage; Stereochemistry; RNA; Enzyme; Nucleotide; Bacteria; Biology","score_opus":0.0030675544727654003,"score_gpt":0.2007550932363098,"score_spread":0.1976875387635444,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004577260","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9810699,0.0018277024,0.00980173,0.0003188953,0.00012189785,0.00020792494,0.0027377924,0.00022557341,0.0036885235],"genre_scores_gemma":[0.97305274,0.0013025099,0.012850708,0.00017695331,0.00007921098,0.0002576827,0.004643135,0.00006725511,0.007569726],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995808,0.00003443341,0.000035885994,0.00011192391,0.00015273184,0.00008424251],"domain_scores_gemma":[0.9995214,0.00014976999,0.0000619693,0.00005790536,0.00013611272,0.00007289619],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020942473,0.0004333402,0.00072003645,0.0005335789,0.00029235595,0.0005311521,0.00045666922,0.0005399653,0.00080604135],"category_scores_gemma":[0.0006163832,0.00021730665,0.00034961905,0.00065794896,0.00021006048,0.00035319204,0.00032047788,0.00071747985,0.00060342235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000035731086,0.000016779404,0.00019352995,0.000020418673,0.0000012262541,0.000046219888,0.0000147454575,0.00001425566,0.99866307,0.000019673767,0.000012615441,0.000961791],"study_design_scores_gemma":[0.000005983481,0.00027760465,0.008479523,0.000007876195,0.000019694664,0.0002522661,0.000069378,0.00047344863,0.98928934,0.000040549807,0.0010751026,0.000009190964],"about_ca_topic_score_codex":0.0041824724,"about_ca_topic_score_gemma":0.0032355895,"teacher_disagreement_score":0.0041824724,"about_ca_system_score_codex":0.0004619864,"about_ca_system_score_gemma":0.00062139455,"threshold_uncertainty_score":0.008316219},"labels":[],"label_agreement":null},{"id":"W2004584037","doi":"10.1016/j.bmcl.2009.09.099","title":"A new approach to the synthesis of polyunsaturated deuterated isoprostanes: Total synthesis of d4-5-epi-8,12-iso-iPF3α-VI and d4-8,12-iso-iPF3α-VI","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Chemistry; Isoprostanes; Eicosapentaenoic acid; Synthon; Docosahexaenoic acid; Polyunsaturated fatty acid; Population; Oxidative stress; Biochemistry; Fatty acid; Stereochemistry; Lipid peroxidation","score_opus":0.010205967266017588,"score_gpt":0.2251996729582651,"score_spread":0.21499370569224752,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004584037","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.46144363,0.007655655,0.50601834,0.0009948842,0.001335892,0.0007787721,0.002397763,0.00069630786,0.018678823],"genre_scores_gemma":[0.8224402,0.009526815,0.14699064,0.00046914836,0.0001670446,0.0005370071,0.0029867417,0.000199669,0.016682675],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986315,0.000018532224,0.000015883714,0.00003946598,0.000025956579,0.00003700167],"domain_scores_gemma":[0.9998441,0.000021715969,0.000018484847,0.000031835436,0.000037598664,0.00004638854],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043194517,0.0007761103,0.0005011719,0.000558939,0.00042398216,0.0003661926,0.00061562966,0.0004646411,0.001994144],"category_scores_gemma":[0.00022832354,0.00023245288,0.00053454837,0.0003939365,0.0003697327,0.0005193724,0.00051856664,0.0011339632,0.00091401476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044362602,0.00010085775,0.00016222717,0.000271215,0.00005274325,0.00023642372,0.00012389234,0.00046865677,0.97411865,0.002655214,0.0002600822,0.021106431],"study_design_scores_gemma":[0.00007552667,0.00062800664,0.00027580385,0.000012990329,0.000057938963,0.00028521332,0.000027212116,0.0005277162,0.98338103,0.000827753,0.013871372,0.00002948061],"about_ca_topic_score_codex":0.00066236884,"about_ca_topic_score_gemma":0.0009425989,"teacher_disagreement_score":0.001994144,"about_ca_system_score_codex":0.00044253835,"about_ca_system_score_gemma":0.00086847576,"threshold_uncertainty_score":0.0066710114},"labels":[],"label_agreement":null},{"id":"W2004693026","doi":"10.1016/s0960-894x(03)00017-9","title":"Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McMaster University","keywords":"Acetamide; Chemistry; Discovery and development of direct thrombin inhibitors; Thrombin; Selectivity; Chemical synthesis; In vitro; Pharmacokinetics; Stereochemistry; Oral administration; Combinatorial chemistry; Pharmacology; Biochemistry; Organic chemistry; Catalysis; Platelet","score_opus":0.008007262920243013,"score_gpt":0.21668884324051882,"score_spread":0.2086815803202758,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004693026","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.940427,0.011561487,0.027813068,0.0010398171,0.00023928728,0.00023658904,0.00065950514,0.0008066101,0.01721676],"genre_scores_gemma":[0.9851618,0.004411733,0.0062301727,0.0003709827,0.000122698,0.000092955845,0.00032225036,0.000050520615,0.0032368444],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998467,0.000042283144,0.000010781836,0.00002674155,0.000030068972,0.000043471526],"domain_scores_gemma":[0.9999194,0.000026286625,0.000017416205,0.0000062569134,0.000007902204,0.0000228012],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034618677,0.0005383198,0.00041486725,0.00028321482,0.00019003569,0.00042722563,0.0006529696,0.00048677062,0.0020321559],"category_scores_gemma":[0.00028525374,0.00022695807,0.00019990097,0.0001868481,0.00027581057,0.00062605995,0.0003936347,0.0007884469,0.00080970844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00087027985,0.00006874049,0.000086971726,0.00015842194,0.000017531022,0.0002445968,0.00005340226,0.0006696282,0.97282404,0.002700919,0.0007993406,0.021506228],"study_design_scores_gemma":[0.00032027962,0.001861106,0.0007262122,0.000013450317,0.000041861927,0.00071182416,0.0000209548,0.0020095096,0.9833077,0.0007001043,0.010255866,0.000031216103],"about_ca_topic_score_codex":0.00022822493,"about_ca_topic_score_gemma":0.000289307,"teacher_disagreement_score":0.0020321559,"about_ca_system_score_codex":0.00022225673,"about_ca_system_score_gemma":0.00012134272,"threshold_uncertainty_score":0.0067982674},"labels":[],"label_agreement":null},{"id":"W2004855633","doi":"10.1016/s0960-894x(01)00126-3","title":"Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) are powerful β-glucosidase inhibitors","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Division of Chemistry; Austrian Science Fund","keywords":"Chemistry; Stereochemistry; Coumarin; Iminosugar; Glycoside hydrolase; Glycoside; D-mannitol; Glucosidases; Enzyme inhibitor; Carboxamide; Enzyme; Mannitol; Biochemistry; Organic chemistry","score_opus":0.014933842628832631,"score_gpt":0.21880661067182458,"score_spread":0.20387276804299195,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004855633","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90858686,0.037704065,0.030361544,0.0012021922,0.00041112656,0.00029539363,0.0014165164,0.00061650516,0.019405749],"genre_scores_gemma":[0.9711671,0.012870522,0.0074910675,0.00021725542,0.000085555395,0.00010714608,0.0007579561,0.000025083415,0.0072784084],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993813,0.000011397981,0.0000036678275,0.000011088774,0.000013531888,0.000022133228],"domain_scores_gemma":[0.99996483,0.000004897197,0.000011034414,0.0000026075302,0.0000029069768,0.0000137139],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014926001,0.0005060958,0.00032584375,0.00018388203,0.00014187057,0.00033912036,0.00032944247,0.00027509965,0.0017179055],"category_scores_gemma":[0.00008351921,0.0001618912,0.00014430733,0.00015052994,0.00028512132,0.00034495594,0.00025365673,0.0006758354,0.0005530511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00059492,0.00008744791,0.000119221004,0.00018908628,0.000012353314,0.00038506964,0.000040539275,0.00082012056,0.9764215,0.002278493,0.00063928985,0.018411955],"study_design_scores_gemma":[0.00013950228,0.00097430433,0.00060992443,0.000008865771,0.000025616848,0.00061148417,0.000018835217,0.0010418023,0.9755853,0.00017947725,0.020789871,0.0000150560345],"about_ca_topic_score_codex":0.00031912935,"about_ca_topic_score_gemma":0.00045741838,"teacher_disagreement_score":0.0017179055,"about_ca_system_score_codex":0.00041838127,"about_ca_system_score_gemma":0.00015126592,"threshold_uncertainty_score":0.0057469606},"labels":[],"label_agreement":null},{"id":"W2004882432","doi":"10.1016/j.bmcl.2013.03.043","title":"Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-Arylproline analogs","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Protease; Moiety; NS3; Enzyme; Chemical synthesis; Stereochemistry; Combinatorial chemistry; Structure–activity relationship; Enzyme inhibitor; Protease inhibitor (pharmacology); Biochemistry; Computational biology; In vitro; Virology; Virus; Biology","score_opus":0.017214695586522954,"score_gpt":0.2482157043413038,"score_spread":0.23100100875478086,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2004882432","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9553431,0.012844583,0.0142181525,0.00035684655,0.00020099782,0.0006009867,0.001694444,0.0003381656,0.014402663],"genre_scores_gemma":[0.9733965,0.007043168,0.012374307,0.00019867171,0.000038575727,0.00015337467,0.0011874952,0.000037898866,0.005570037],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988997,0.000017946022,0.000012024995,0.000019970312,0.000030180885,0.000029869405],"domain_scores_gemma":[0.999948,0.000005134393,0.000016473708,0.0000047805534,0.000010038935,0.000015573198],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715107,0.0005002589,0.00036587485,0.00024301103,0.00017286767,0.00025212325,0.00040941755,0.00022524125,0.0017168451],"category_scores_gemma":[0.00013341632,0.00016721642,0.00020876482,0.0002171163,0.00011887545,0.00021863528,0.00019078242,0.00043598787,0.00042930685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080310507,0.00040393983,0.0003504632,0.000391077,0.000054282897,0.0004734101,0.00007741356,0.004950968,0.9484503,0.00066582067,0.0009707817,0.042408418],"study_design_scores_gemma":[0.00045454677,0.0047418396,0.0017429411,0.00003064297,0.000101017176,0.0008108236,0.00003917808,0.003315764,0.9591674,0.00012903301,0.029427363,0.00003958769],"about_ca_topic_score_codex":0.0006087393,"about_ca_topic_score_gemma":0.002190905,"teacher_disagreement_score":0.0017168451,"about_ca_system_score_codex":0.00031157592,"about_ca_system_score_gemma":0.0003273208,"threshold_uncertainty_score":0.005743444},"labels":[],"label_agreement":null},{"id":"W2005015636","doi":"10.1016/j.bmcl.2008.12.097","title":"Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Histone Acetyltransferases; Acetylation; Quinoline; Histone; Histone acetyltransferase; Enzyme; Biochemistry; In vitro; Western blot; Histone H3; Acetyltransferases; Molecular biology","score_opus":0.010983231273324135,"score_gpt":0.2608450851638985,"score_spread":0.24986185389057436,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2005015636","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9612618,0.016340472,0.011478198,0.00043095424,0.00016729292,0.0004474671,0.001032118,0.00047157507,0.008370109],"genre_scores_gemma":[0.98313636,0.004875432,0.0045198305,0.00016672815,0.00004077573,0.00011854611,0.0016718232,0.000038982835,0.00543153],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986684,0.00002561623,0.000012116902,0.000018764591,0.000037180474,0.000039365612],"domain_scores_gemma":[0.99988663,0.000022864928,0.000024248813,0.000009639736,0.000033123026,0.000023524732],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003284659,0.00043156385,0.0005687036,0.00051450863,0.00018421459,0.00032203223,0.0006813094,0.0003399121,0.0019975852],"category_scores_gemma":[0.0002362092,0.00024187836,0.00041072696,0.00022159696,0.00016812803,0.00020357095,0.00018449198,0.0005710149,0.0005311602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008506125,0.00030180337,0.00049904524,0.0001359853,0.000055286047,0.00024659833,0.000041136816,0.0010228667,0.9811644,0.0005243714,0.0004902227,0.014667729],"study_design_scores_gemma":[0.00071975746,0.0039941217,0.0033342498,0.000028324732,0.0001758841,0.0009630877,0.000042527474,0.0034511592,0.9721715,0.0001985008,0.014888973,0.00003194165],"about_ca_topic_score_codex":0.0012556739,"about_ca_topic_score_gemma":0.0028223607,"teacher_disagreement_score":0.0019975852,"about_ca_system_score_codex":0.0005091046,"about_ca_system_score_gemma":0.00027795252,"threshold_uncertainty_score":0.0066825747},"labels":[],"label_agreement":null},{"id":"W2006499174","doi":"10.1016/j.bmcl.2009.12.068","title":"[Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency; Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"DOTA; Neuropeptide Y receptor; Chemistry; Receptor; Pet imaging; Positron emission tomography; Chelation; Neuropeptide; Stereochemistry; Nuclear medicine; Biochemistry; Medicine","score_opus":0.01421292859705492,"score_gpt":0.2253311827973419,"score_spread":0.211118254200287,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2006499174","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9655484,0.004986806,0.019871976,0.0004139006,0.00019229965,0.00018508236,0.0005214982,0.0003257495,0.007954223],"genre_scores_gemma":[0.98740155,0.0013347346,0.0078109507,0.00025777624,0.000015992347,0.000054658965,0.00042501578,0.000028757497,0.002670568],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991417,0.000012516537,0.000004852163,0.000021068416,0.000013954339,0.00003334644],"domain_scores_gemma":[0.99996424,0.0000044346925,0.000008624056,0.0000025396498,0.000003933685,0.00001627492],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014239695,0.00032375514,0.00038866716,0.00012610861,0.00013046018,0.00029938962,0.0004908319,0.00043967756,0.0010422699],"category_scores_gemma":[0.000101413076,0.00015664204,0.00012277663,0.00010501938,0.00021593791,0.00028486835,0.00022788398,0.00044486034,0.00040027135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040248552,0.00005517844,0.00007134801,0.0001249882,0.000013002114,0.0001630449,0.00002572892,0.0006134459,0.9878372,0.0006167743,0.00036893855,0.009707953],"study_design_scores_gemma":[0.00016299397,0.00095044944,0.00054364884,0.00000880214,0.000025236539,0.00059391,0.000015101594,0.0020331072,0.9890085,0.00013657716,0.00650357,0.000018222394],"about_ca_topic_score_codex":0.00064919906,"about_ca_topic_score_gemma":0.00070036796,"teacher_disagreement_score":0.0010422699,"about_ca_system_score_codex":0.00044447763,"about_ca_system_score_gemma":0.00021709148,"threshold_uncertainty_score":0.0034867525},"labels":[],"label_agreement":null},{"id":"W2006937326","doi":"10.1016/s0960-894x(02)00307-4","title":"Inhibition of feline immunodeficiency virus (FIV) replication by DNA binding polyamides","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Center for Research Resources; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Feline immunodeficiency virus; Chemistry; Replication (statistics); Minor groove; Virology; DNA; Virus; Viral replication; Lentivirus; Molecular biology; Biochemistry; Viral disease; Biology","score_opus":0.014950631087932488,"score_gpt":0.23459609000781104,"score_spread":0.21964545891987855,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2006937326","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98796403,0.0040035844,0.0031100265,0.000100290585,0.00007329723,0.0000535892,0.00012226141,0.00009598605,0.004476965],"genre_scores_gemma":[0.9946327,0.0013753971,0.0016070461,0.000057398098,0.000021638494,0.00004340171,0.00015230021,0.000008193989,0.0021019964],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991894,0.000014374949,0.000004848402,0.00001201545,0.000013764238,0.000036013345],"domain_scores_gemma":[0.99993515,0.000025686137,0.0000135664,0.0000055940695,0.0000060607576,0.000013847172],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014132453,0.00036707128,0.00015758465,0.00017150825,0.00013590358,0.00019986324,0.00024323887,0.00026993456,0.0011012612],"category_scores_gemma":[0.0001672314,0.00011007687,0.00021996387,0.00007319877,0.0001538972,0.00015780826,0.00017401855,0.000404748,0.00019887742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026050757,0.000050735867,0.000055261775,0.000052050753,0.0000052389373,0.000055534332,0.000011455786,0.0002484683,0.99411184,0.00020499605,0.000063480715,0.0048804567],"study_design_scores_gemma":[0.000031575357,0.0005779898,0.00043785706,0.000005379661,0.0000064447117,0.00007277373,0.0000050479866,0.0004886114,0.99684626,0.000029166496,0.0014952819,0.0000036211939],"about_ca_topic_score_codex":0.00070335815,"about_ca_topic_score_gemma":0.0007389164,"teacher_disagreement_score":0.0011012612,"about_ca_system_score_codex":0.00029498833,"about_ca_system_score_gemma":0.0001236306,"threshold_uncertainty_score":0.003684044},"labels":[],"label_agreement":null},{"id":"W2007092166","doi":"10.1016/j.bmcl.2013.09.042","title":"Synthesis and immunological activity of an oligosaccharide-conjugate as a vaccine candidate against Group A Streptococcus","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Glycoconjugate; Immunogenicity; Conjugate; Hapten; Toxoid; Conjugate vaccine; Stereochemistry; Amine gas treating; Biochemistry; Antigen; Streptococcus pneumoniae; Immunization; Immunology; Organic chemistry","score_opus":0.00848097686337957,"score_gpt":0.24137034136521807,"score_spread":0.2328893645018385,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2007092166","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9939167,0.000791396,0.0027182791,0.00007984554,0.000032639076,0.0000601216,0.0001016315,0.000018587574,0.0022808164],"genre_scores_gemma":[0.99576974,0.0003178162,0.001578207,0.000028968045,0.000007862988,0.000015005524,0.0001708511,0.000006704412,0.0021050498],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999459,0.000013444881,0.0000035856142,0.0000070862384,0.000010665719,0.000019353558],"domain_scores_gemma":[0.99995124,0.0000075530484,0.000008118229,0.000004896112,0.000010115351,0.000018117904],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014953381,0.00028115936,0.00016542706,0.00020248146,0.00015151405,0.00022964703,0.00020941134,0.00024903988,0.0010708485],"category_scores_gemma":[0.00015721575,0.00010292668,0.00017789348,0.00016567741,0.00012411631,0.00017613024,0.00018643968,0.00027814205,0.00027816033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00045352313,0.00013452068,0.00024994815,0.00005951715,0.000013520073,0.00021490913,0.000041487816,0.0011400542,0.9910596,0.00042497544,0.00009479798,0.0061131804],"study_design_scores_gemma":[0.00006774039,0.0016635394,0.00069063867,0.000004870349,0.000025720963,0.0001233053,0.000014201241,0.0012735636,0.9938239,0.000060451846,0.002245611,0.0000065063114],"about_ca_topic_score_codex":0.00051555724,"about_ca_topic_score_gemma":0.00046996886,"teacher_disagreement_score":0.0010708485,"about_ca_system_score_codex":0.00018541553,"about_ca_system_score_gemma":0.00030579788,"threshold_uncertainty_score":0.0035823584},"labels":[],"label_agreement":null},{"id":"W2007103825","doi":"10.1016/j.bmcl.2008.01.122","title":"Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Inhibitory postsynaptic potential; Thrombin; Stereochemistry; Core (optical fiber); Discovery and development of direct thrombin inhibitors; Structure–activity relationship; Combinatorial chemistry; In vitro; Biochemistry; Neuroscience; Internal medicine","score_opus":0.045395601486678615,"score_gpt":0.2562850127899416,"score_spread":0.21088941130326297,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2007103825","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9799818,0.0022810202,0.011191224,0.000111623216,0.000042047068,0.00017308106,0.00027487564,0.00012097788,0.0058233677],"genre_scores_gemma":[0.9861168,0.0010391943,0.010081217,0.00006926257,0.000010293116,0.00009059502,0.00023702138,0.000022346156,0.0023332387],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999305,0.000017134318,0.000006156148,0.000013837102,0.000010988763,0.000021316357],"domain_scores_gemma":[0.9999511,0.000008320421,0.000013547301,0.00000609889,0.0000070598403,0.000013811494],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016165504,0.00030748587,0.00016137736,0.00013209815,0.00015551854,0.00032110175,0.00037179654,0.00025329762,0.0010367996],"category_scores_gemma":[0.00016898903,0.00017342802,0.00016916073,0.00014213202,0.00012343518,0.00027558082,0.00022809766,0.0003968106,0.00036070024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010066909,0.0001626626,0.00024896977,0.00026811214,0.000014360558,0.00040366143,0.00009173204,0.0028187125,0.9626952,0.0026771356,0.00044175817,0.029171066],"study_design_scores_gemma":[0.00010943878,0.0013805198,0.00051901635,0.000010943131,0.000016128603,0.0003507365,0.000014738757,0.003466429,0.9888292,0.00030844333,0.0049776104,0.000016821085],"about_ca_topic_score_codex":0.00027335837,"about_ca_topic_score_gemma":0.00035458573,"teacher_disagreement_score":0.0010367996,"about_ca_system_score_codex":0.0002376636,"about_ca_system_score_gemma":0.0002338253,"threshold_uncertainty_score":0.0034683943},"labels":[],"label_agreement":null},{"id":"W2007949090","doi":"10.1016/j.bmcl.2013.02.005","title":"Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Thiourea; Chemistry; Chemical biology; Small molecule; Chaperone (clinical); MreB; Mechanism of action; Biochemistry; Bacteria; Biophysics; In vitro; Escherichia coli; Biology; Genetics; Organic chemistry; Gene","score_opus":0.01315485173893235,"score_gpt":0.22945630869038472,"score_spread":0.21630145695145236,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2007949090","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9929357,0.0024031631,0.0026500334,0.00008948491,0.000020022597,0.000032083408,0.00023112394,0.00007404812,0.0015643184],"genre_scores_gemma":[0.99321884,0.0007320012,0.0024469215,0.000050494647,0.0000075493786,0.000029699024,0.00044120176,0.000024673467,0.0030486006],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998735,0.000017845223,0.00000860671,0.000020388652,0.000040706454,0.000038904276],"domain_scores_gemma":[0.9998857,0.000023598861,0.00003218459,0.000014021601,0.00002807629,0.00001637435],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023937147,0.00031373365,0.0003644033,0.00016379985,0.00024291952,0.00020975685,0.00027849575,0.000352314,0.0011100337],"category_scores_gemma":[0.00022675391,0.00012745243,0.00024807654,0.00017849055,0.00020041395,0.00018299717,0.00011548123,0.00045593744,0.00027362435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012360439,0.000032771397,0.00007559164,0.000035790115,0.000009053224,0.00006012248,0.000028545091,0.0000789666,0.9982868,0.000113464695,0.000041001214,0.0011142482],"study_design_scores_gemma":[0.0000069196126,0.00018353168,0.0007568687,0.0000018944646,0.0000044440535,0.000077255834,0.0000124598055,0.00030218944,0.99778664,0.000014210179,0.0008505451,0.0000030725132],"about_ca_topic_score_codex":0.0020703794,"about_ca_topic_score_gemma":0.0020561784,"teacher_disagreement_score":0.0020703794,"about_ca_system_score_codex":0.00044908872,"about_ca_system_score_gemma":0.00026967656,"threshold_uncertainty_score":0.0041166544},"labels":[],"label_agreement":null},{"id":"W2008268931","doi":"10.1016/j.bmcl.2013.01.063","title":"Ester hydrolysis by a histidine-containing cavitein","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Chemistry; Hydrolysis; Histidine; Catalysis; Ester hydrolysis; Organic chemistry; Stereochemistry; Enzyme; Combinatorial chemistry","score_opus":0.0034722184358896117,"score_gpt":0.1844596591523971,"score_spread":0.1809874407165075,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2008268931","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9966671,0.00012747601,0.0022222544,0.000033945536,0.000009417189,0.000007677288,0.00005433568,0.000030663934,0.00084721367],"genre_scores_gemma":[0.9976986,0.00006840353,0.00072017807,0.000009101364,0.0000026103464,0.0000025932159,0.00013257778,0.000010286341,0.001355654],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999057,0.00001740869,0.000005490074,0.000021519716,0.000016220403,0.000033693865],"domain_scores_gemma":[0.99992836,0.000022000979,0.000017433476,0.000008427634,0.000007702974,0.00001603337],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018336081,0.00019173471,0.00016478961,0.00008625493,0.00009629147,0.00021954438,0.00020570299,0.0002483049,0.00081279984],"category_scores_gemma":[0.00018861536,0.000062194275,0.00013217021,0.0001105437,0.0001306286,0.00022894786,0.0001567281,0.00024183777,0.0002900613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043442484,0.000030346737,0.0001898068,0.000018893064,0.0000053426706,0.00011565283,0.000020860845,0.0002525134,0.99672,0.00016476694,0.000037840022,0.0020095562],"study_design_scores_gemma":[0.000009964619,0.00012003789,0.00029938083,0.0000011072675,0.0000025999173,0.00007065775,0.000005839201,0.0006581609,0.9983041,0.000018284933,0.0005068841,0.000002895354],"about_ca_topic_score_codex":0.00047887664,"about_ca_topic_score_gemma":0.00037556406,"teacher_disagreement_score":0.00081279984,"about_ca_system_score_codex":0.00027474973,"about_ca_system_score_gemma":0.00014316087,"threshold_uncertainty_score":0.0027191043},"labels":[],"label_agreement":null},{"id":"W2008510322","doi":"10.1016/j.bmcl.2013.12.035","title":"Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Potency; In vivo; In vitro; Pharmacology; Moiety; Stereochemistry; Biochemistry","score_opus":0.004424556329747651,"score_gpt":0.1807453371217449,"score_spread":0.17632078079199726,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2008510322","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96784425,0.013773107,0.010598268,0.00067881687,0.00010608056,0.00024271524,0.0008086358,0.00031689715,0.005631275],"genre_scores_gemma":[0.9889964,0.004029205,0.003753631,0.00015641873,0.000021753393,0.000054904474,0.0004933755,0.000015644908,0.0024785474],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991477,0.000019036932,0.000006764479,0.000015891714,0.000018039884,0.000025525835],"domain_scores_gemma":[0.99990785,0.000015170371,0.000029227129,0.000009187879,0.000021516767,0.00001698327],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027771253,0.00039574623,0.00037335776,0.0002530099,0.0001500805,0.00042024057,0.00031017815,0.00023645259,0.0013845277],"category_scores_gemma":[0.00023744798,0.00015902681,0.00019768049,0.00016837558,0.00015591545,0.00017971842,0.00018394919,0.0005461406,0.00028161894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018564686,0.00026452835,0.0015257385,0.000346252,0.00006223184,0.00062398333,0.0000718035,0.0015812145,0.92996365,0.0016923832,0.0015919528,0.06041981],"study_design_scores_gemma":[0.0007408696,0.0039912737,0.0043545812,0.000034679597,0.00017017654,0.002074783,0.000032161963,0.00357068,0.9639923,0.00032499133,0.020684,0.000029562605],"about_ca_topic_score_codex":0.00043447228,"about_ca_topic_score_gemma":0.0013070655,"teacher_disagreement_score":0.0013845277,"about_ca_system_score_codex":0.00040558347,"about_ca_system_score_gemma":0.00033582508,"threshold_uncertainty_score":0.004631698},"labels":[],"label_agreement":null},{"id":"W2009032145","doi":"10.1016/j.bmcl.2014.12.078","title":"Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Lipophilicity; In vivo; Toxicity; Pharmacology; Chemistry; In vitro; Biochemistry; Biology","score_opus":0.04453094156856944,"score_gpt":0.31743083403052524,"score_spread":0.2728998924619558,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2009032145","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.980885,0.0024101362,0.012077632,0.00020286045,0.000040013114,0.00006719353,0.0002951923,0.00025016975,0.003771873],"genre_scores_gemma":[0.99661106,0.00022392972,0.0024946062,0.000033721517,0.000002811417,0.000039870345,0.00012691147,0.00002162553,0.00044540942],"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989367,0.00003164625,0.000008852851,0.000020510015,0.000019685483,0.000025655741],"domain_scores_gemma":[0.999747,0.0001431428,0.00003746477,0.000013650804,0.000037340924,0.000021509099],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005364661,0.00071470405,0.000637652,0.00038085852,0.0002279696,0.0005834433,0.0005532657,0.0005888638,0.0021186916],"category_scores_gemma":[0.000959102,0.00024725692,0.000496888,0.00025961528,0.00019514517,0.0003457888,0.00035078873,0.00058889354,0.00024056603],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002481902,0.0005536768,0.0027885542,0.00025268897,0.0002613853,0.00022096683,0.000073411466,0.9053133,0.051748835,0.00044082597,0.00071883126,0.03514553],"study_design_scores_gemma":[0.00038918856,0.0030640676,0.0033652473,0.000041051695,0.00036191376,0.00011771187,0.000105180676,0.941397,0.049094163,0.00033417268,0.0016662796,0.00006401463],"about_ca_topic_score_codex":0.0022495151,"about_ca_topic_score_gemma":0.0032631317,"teacher_disagreement_score":0.0022495151,"about_ca_system_score_codex":0.00042412124,"about_ca_system_score_gemma":0.0005224683,"threshold_uncertainty_score":0.0070877075},"labels":[],"label_agreement":null},{"id":"W2009503877","doi":"10.1016/j.bmcl.2006.09.066","title":"Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: A semi-empirical investigation","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Trace Elements in Health","field":"Nursing","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Chemistry; Pyrophosphate; Phosphate; Inositol; Inositol phosphate; Enzyme; Serine; Polyphosphate; Biochemistry; Receptor","score_opus":0.011947242255676704,"score_gpt":0.24441920062518985,"score_spread":0.23247195836951315,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2009503877","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9162348,0.0007080771,0.046778515,0.0009395234,0.000021533075,0.00016886884,0.00029100385,0.000066509725,0.034791175],"genre_scores_gemma":[0.9917985,0.00049326255,0.006181912,0.000028899416,0.0000053343806,0.00004731666,0.00011562402,0.000010310459,0.0013188379],"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9994168,0.0002512775,0.00004714143,0.00010800397,0.00012181246,0.000055006065],"domain_scores_gemma":[0.98490673,0.012830887,0.0005539611,0.0008856098,0.0007462826,0.00007657238],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0027608147,0.00040502456,0.000576298,0.0006551485,0.00073860976,0.0010681801,0.0017728743,0.00045964713,0.008877197],"category_scores_gemma":[0.013713398,0.00033963093,0.0005466291,0.00072391005,0.0026079426,0.003598797,0.0013021978,0.0007370709,0.0004867029],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014730324,0.00080255856,0.017700111,0.0022658438,0.00019132256,0.0015792182,0.004199592,0.048028667,0.00858182,0.853553,0.001531006,0.06009393],"study_design_scores_gemma":[0.0003342977,0.0009892222,0.01594194,0.00036848616,0.0002545751,0.0015049991,0.007825175,0.35073566,0.025761237,0.5873505,0.0088274805,0.0001065485],"about_ca_topic_score_codex":0.0021464732,"about_ca_topic_score_gemma":0.0011665745,"teacher_disagreement_score":0.008877197,"about_ca_system_score_codex":0.00086757506,"about_ca_system_score_gemma":0.001022507,"threshold_uncertainty_score":0.02969718},"labels":[],"label_agreement":null},{"id":"W2009699519","doi":"10.1016/j.bmcl.2007.05.056","title":"Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Fastidious organism; Chemistry; Gram; Stereochemistry; Antibacterial activity; Aryl; Chemical synthesis; Pyrazole; Structure–activity relationship; Gram-positive bacteria; Antibacterial agent; Gram-negative bacteria; Combinatorial chemistry; Alkyl; In vitro; Bacteria; Antimicrobial; Organic chemistry; Biochemistry; Antibiotics; Escherichia coli","score_opus":0.013812636924347423,"score_gpt":0.23651908575325586,"score_spread":0.22270644882890844,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2009699519","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97698236,0.009428231,0.006192604,0.0002682496,0.000112013586,0.00014865266,0.00068843167,0.00015282973,0.0060266317],"genre_scores_gemma":[0.9791986,0.009660849,0.0052353214,0.00015061996,0.00003692706,0.00011728907,0.0012088384,0.000017018738,0.004374567],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999622,0.0000063290795,0.0000040937953,0.0000042283814,0.0000064267865,0.000016758746],"domain_scores_gemma":[0.99995863,0.000007121354,0.00001406492,0.0000047101703,0.0000048401544,0.000010621478],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013717258,0.00040436987,0.00027100497,0.00010498404,0.00013604165,0.00021057382,0.0004018471,0.0002113013,0.0019009201],"category_scores_gemma":[0.00013527121,0.00013856014,0.00016213839,0.00015572614,0.00019603773,0.00020328892,0.00020820147,0.0002922191,0.00046756933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011367534,0.0001830319,0.00028592875,0.00048794452,0.00001657075,0.0005564496,0.00013241556,0.003604679,0.9576812,0.0014291522,0.0011666715,0.033319253],"study_design_scores_gemma":[0.0013910722,0.011297673,0.007972935,0.00009270207,0.00013149485,0.0023911188,0.00012336926,0.004261333,0.9220005,0.00077139045,0.049477622,0.000088803135],"about_ca_topic_score_codex":0.00046771797,"about_ca_topic_score_gemma":0.0011355495,"teacher_disagreement_score":0.0019009201,"about_ca_system_score_codex":0.00023788781,"about_ca_system_score_gemma":0.000343644,"threshold_uncertainty_score":0.00635916},"labels":[],"label_agreement":null},{"id":"W2009792376","doi":"10.1016/j.bmcl.2007.09.062","title":"Synthesis, antibacterial activity, and quantitative structure–activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" altimg=\"si2.gif\" overflow=\"scroll\"><mml:mrow><mml:mn>2</mml:mn><mml:mi>H</mml:mi></mml:mrow></mml:math>)-benzofuranone derivatives","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":78,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University","funders":"","keywords":"Chemistry; Bacillus subtilis; Staphylococcus epidermidis; Klebsiella pneumoniae; Gram-positive bacteria; Antibacterial activity; Bacteria; Nitroimidazole; Gram; Quantitative structure–activity relationship; Stereochemistry; Antibacterial agent; Structure–activity relationship; Staphylococcus aureus; Escherichia coli; Organic chemistry; Biochemistry; Antibiotics; In vitro; Biology","score_opus":0.027125454132509802,"score_gpt":0.24653603432764248,"score_spread":0.21941058019513268,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2009792376","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97718686,0.009401426,0.0061105983,0.00023937091,0.00004468075,0.00016033326,0.0018691939,0.00010918472,0.0048782625],"genre_scores_gemma":[0.983639,0.003952655,0.0049297367,0.000083452236,0.000022963839,0.000113665534,0.0015017458,0.000018129356,0.0057386965],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999062,0.00002470041,0.000010542168,0.000018232406,0.000020359143,0.000020056868],"domain_scores_gemma":[0.99989486,0.000024775105,0.000031745007,0.000012700855,0.000016634582,0.000019234241],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023963634,0.00023097356,0.00017772701,0.00024809217,0.00009618446,0.00016260984,0.00020300767,0.00015822485,0.0026962443],"category_scores_gemma":[0.0002491026,0.0001773539,0.00020592217,0.0001669795,0.00017015335,0.00022544363,0.000105089915,0.00025579613,0.00042399365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005218622,0.00015066745,0.00027979666,0.00011933767,0.000016217875,0.000039385446,0.000038125916,0.0009686459,0.98694116,0.0003710118,0.00026453251,0.010289159],"study_design_scores_gemma":[0.00012714273,0.0027831413,0.0044001923,0.0000145545855,0.000037000224,0.00015172447,0.00001662262,0.0015711864,0.9864093,0.00008289241,0.004391623,0.000014547675],"about_ca_topic_score_codex":0.0010563054,"about_ca_topic_score_gemma":0.0025306286,"teacher_disagreement_score":0.0026962443,"about_ca_system_score_codex":0.00033909257,"about_ca_system_score_gemma":0.00025251467,"threshold_uncertainty_score":0.009019852},"labels":[],"label_agreement":null},{"id":"W2010029383","doi":"10.1016/j.bmcl.2010.06.155","title":"Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Substituent; Chemistry; Ring (chemistry); Positron emission tomography; Stereochemistry; Nuclear medicine; Organic chemistry","score_opus":0.010061320029808413,"score_gpt":0.24838602293698023,"score_spread":0.2383247029071718,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010029383","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9622448,0.0029915802,0.028480312,0.00016602296,0.000057434525,0.0001681159,0.00040010488,0.00027227672,0.0052194092],"genre_scores_gemma":[0.9815735,0.0015751282,0.013389502,0.00013845056,0.000029576664,0.00013042458,0.0008995829,0.00009203088,0.002171691],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981314,0.000042125157,0.000018326162,0.00003106867,0.000033044114,0.00006228124],"domain_scores_gemma":[0.9997774,0.000055294196,0.00006704835,0.000028102473,0.000035214867,0.000036923277],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00048739184,0.0004174355,0.00028269712,0.00040006684,0.00022897689,0.000340181,0.00030477915,0.00067319017,0.0015145217],"category_scores_gemma":[0.00044446532,0.0003530027,0.00031757177,0.00042356184,0.00019336578,0.0004314256,0.00031868333,0.00051831634,0.0007702282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019643946,0.000017434844,0.00009114051,0.000022462358,0.0000070562546,0.00007201664,0.000013193297,0.000096093965,0.99795085,0.00015353868,0.000029037643,0.0013508319],"study_design_scores_gemma":[0.00005176153,0.00044999903,0.0008560187,0.000007683143,0.00002950915,0.00034339997,0.000009836379,0.00056789804,0.9952932,0.00008707268,0.002295655,0.000007975707],"about_ca_topic_score_codex":0.00036438296,"about_ca_topic_score_gemma":0.0008337132,"teacher_disagreement_score":0.0015145217,"about_ca_system_score_codex":0.00030168844,"about_ca_system_score_gemma":0.00019078515,"threshold_uncertainty_score":0.0050665736},"labels":[],"label_agreement":null},{"id":"W2010090914","doi":"10.1016/j.bmcl.2005.06.060","title":"Inhibition of mandelate racemase by the substrate–intermediate–product analogue 1,1-diphenyl-1-hydroxymethylphosphonate","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Phosphonate; Substrate (aquarium); Stereochemistry; Carboxylate; Enzyme; Substrate analog; Non-competitive inhibition; Product inhibition; Chemical synthesis; Active site; Organic chemistry; Biochemistry; In vitro","score_opus":0.005043770218694882,"score_gpt":0.20815542351648783,"score_spread":0.20311165329779296,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010090914","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9911308,0.0024905808,0.0017466872,0.00013067138,0.00006411792,0.000047761947,0.00022664499,0.00011768767,0.004044908],"genre_scores_gemma":[0.9958275,0.00067584444,0.0010613222,0.000029300703,0.000012360982,0.000022362981,0.0003531585,0.000014906749,0.0020032318],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997372,0.000059251553,0.000023075296,0.00004852954,0.00004600845,0.00008594002],"domain_scores_gemma":[0.9998431,0.000058965932,0.00002819713,0.000019759327,0.000018927083,0.000030970557],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328095,0.00048560253,0.0004821557,0.00020682694,0.00021476341,0.00034781417,0.00037032535,0.0004996005,0.0019244846],"category_scores_gemma":[0.0003248924,0.00024432456,0.0003495554,0.0001690435,0.00026211832,0.00028771162,0.0002601321,0.00060918095,0.0005228748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008745179,0.000053363765,0.00010221653,0.000050994513,0.000009851724,0.00007204256,0.000023338307,0.00017282608,0.9965275,0.00021867816,0.000059460373,0.0018351916],"study_design_scores_gemma":[0.000018900555,0.00031242787,0.00031759104,0.0000016085262,0.000004083612,0.00005028649,0.000005001619,0.0003442168,0.9983255,0.000015963002,0.0006017813,0.0000027014175],"about_ca_topic_score_codex":0.0012138133,"about_ca_topic_score_gemma":0.0016265273,"teacher_disagreement_score":0.0019244846,"about_ca_system_score_codex":0.00047517373,"about_ca_system_score_gemma":0.00040909296,"threshold_uncertainty_score":0.006438017},"labels":[],"label_agreement":null},{"id":"W2010474651","doi":"10.1016/j.bmcl.2005.08.085","title":"Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide–protein interactions","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Bivalent (engine); Chemistry; Linker; Moiety; Stereochemistry; Thrombin; Peptide; Enzyme; Plasma protein binding; Small molecule; Combinatorial chemistry; Biochemistry; Binding site","score_opus":0.007282433071458312,"score_gpt":0.23394350875848324,"score_spread":0.22666107568702493,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010474651","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93686795,0.0013626206,0.050606716,0.00028697585,0.00018500691,0.00009639494,0.00020432145,0.0009259115,0.009463997],"genre_scores_gemma":[0.9692058,0.0010344534,0.015325586,0.00016819131,0.00002340584,0.000064161395,0.0002780993,0.00021909644,0.0136811165],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997949,0.000031460146,0.000018725128,0.000053159496,0.00005547877,0.00004641755],"domain_scores_gemma":[0.99985504,0.000033324697,0.000046489808,0.000021315847,0.000014326514,0.000029515486],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029724344,0.0005504413,0.00030511993,0.00018358088,0.00017449458,0.00092711195,0.0005488487,0.00041407507,0.0018343471],"category_scores_gemma":[0.0002886901,0.00032467284,0.00017121708,0.00021114682,0.00037153062,0.0004409458,0.00048187358,0.0009735076,0.0010077519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000119843986,0.000054802418,0.000092958035,0.000033563716,0.000009320627,0.000087943365,0.000029577084,0.00076608517,0.9915767,0.0019716525,0.00015247217,0.005105043],"study_design_scores_gemma":[0.000017349736,0.00009351428,0.00006734759,0.0000025240959,0.000008940235,0.000074126736,0.000008559444,0.0014240172,0.9932081,0.0001186294,0.0049699033,0.0000068615504],"about_ca_topic_score_codex":0.00030459586,"about_ca_topic_score_gemma":0.0003690506,"teacher_disagreement_score":0.0018343471,"about_ca_system_score_codex":0.00035884298,"about_ca_system_score_gemma":0.00018818658,"threshold_uncertainty_score":0.006136477},"labels":[],"label_agreement":null},{"id":"W2010654750","doi":"10.1016/j.bmcl.2007.12.047","title":"The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":473,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Cathepsin K; Chemistry; Enzyme inhibitor; Cathepsin; Intracellular; Pharmacology; Cathepsin L; Biochemistry; Enzyme; In vitro; Biology","score_opus":0.014609025596029317,"score_gpt":0.2536845308897437,"score_spread":0.23907550529371438,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010654750","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93451965,0.03655789,0.008181935,0.0042420793,0.00066354213,0.0002060655,0.00096468424,0.0003132884,0.0143508315],"genre_scores_gemma":[0.9728749,0.015057506,0.003065426,0.00085579953,0.00011378722,0.000046622,0.0007788882,0.000019954316,0.0071871043],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992037,0.0000097985785,0.0000043837917,0.000011256323,0.000021808948,0.000032334614],"domain_scores_gemma":[0.9999447,0.0000051126913,0.000007770952,0.0000034240309,0.000014426518,0.00002454979],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021328028,0.00036483048,0.00032504392,0.0002822802,0.0001311733,0.0006807278,0.00028103046,0.00049672887,0.00065812457],"category_scores_gemma":[0.00021990557,0.00018002439,0.00021682275,0.0001779062,0.00025866748,0.00034886942,0.00026709572,0.00088852254,0.00032884406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016071039,0.00042385806,0.0016019418,0.0004073842,0.00007803626,0.001224462,0.00010144251,0.0011246382,0.8555827,0.005180359,0.006547526,0.12612048],"study_design_scores_gemma":[0.0010262345,0.0027215467,0.0048189117,0.000045266588,0.00018531337,0.0042300434,0.000082639235,0.004578795,0.88929445,0.0012004855,0.09176645,0.000049847604],"about_ca_topic_score_codex":0.000606904,"about_ca_topic_score_gemma":0.001448036,"teacher_disagreement_score":0.0006807278,"about_ca_system_score_codex":0.0005869284,"about_ca_system_score_gemma":0.0005729915,"threshold_uncertainty_score":0.004258454},"labels":[],"label_agreement":null},{"id":"W2010713047","doi":"10.1016/j.bmcl.2007.10.033","title":"Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Phenanthrene; IC50; Oral administration; Analgesic; Indole test; Orally active; Imidazole; Stereochemistry; Carboxylic acid; In vitro; Biochemistry; Organic chemistry","score_opus":0.004358412619657795,"score_gpt":0.22048880195069037,"score_spread":0.21613038933103257,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010713047","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96861625,0.018879972,0.0047001513,0.00035849685,0.00015735961,0.00010251974,0.0004454363,0.0002714298,0.0064684576],"genre_scores_gemma":[0.9835666,0.008933885,0.0021065685,0.00009440517,0.000040171966,0.000040765575,0.00046882802,0.000018993347,0.0047297874],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999324,0.000012829328,0.000004493608,0.000009714564,0.00001671523,0.000023822131],"domain_scores_gemma":[0.9999696,0.000005371619,0.000007938019,0.0000037769375,0.000003207026,0.000010043452],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018102118,0.0003374794,0.00037590862,0.0001861182,0.00012448612,0.00020609896,0.00036486264,0.00023668807,0.0012864321],"category_scores_gemma":[0.00011706515,0.0001487325,0.0001141669,0.00019904246,0.00016796091,0.00023515352,0.00018181189,0.00056848186,0.00031220034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017233768,0.00022876376,0.000240546,0.0002041024,0.000024057821,0.00035842034,0.00005584161,0.0015587314,0.9607817,0.00091145275,0.00077554316,0.03313746],"study_design_scores_gemma":[0.00075715303,0.0051238965,0.0033022598,0.000023862853,0.00008640974,0.0014107503,0.00003603451,0.0025221126,0.96908164,0.0002786129,0.017350359,0.00002693373],"about_ca_topic_score_codex":0.000262532,"about_ca_topic_score_gemma":0.0009834559,"teacher_disagreement_score":0.0012864321,"about_ca_system_score_codex":0.00023313741,"about_ca_system_score_gemma":0.00015565593,"threshold_uncertainty_score":0.004303515},"labels":[],"label_agreement":null},{"id":"W2010980589","doi":"10.1016/j.bmcl.2010.02.010","title":"Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Limiting; Drug; Potency; Pharmacology; Combinatorial chemistry; Enzyme; Anti-inflammatory; Stereochemistry; In vitro; Biochemistry; Medicine","score_opus":0.008844010666857412,"score_gpt":0.22544991241026047,"score_spread":0.21660590174340305,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010980589","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8876671,0.009639583,0.076698944,0.0006379352,0.00032439624,0.00052185217,0.0013257719,0.00057104195,0.022613296],"genre_scores_gemma":[0.9476425,0.0035951368,0.040529102,0.00024608913,0.000023987768,0.00015250906,0.0006665408,0.000045156074,0.0070990426],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999243,0.000008330424,0.0000073825995,0.000014202349,0.000015266234,0.000030553627],"domain_scores_gemma":[0.99995553,0.00000651998,0.000012579534,0.0000040281793,0.0000061525575,0.000015102381],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013584565,0.0004997484,0.00039780635,0.00024579445,0.00022010884,0.0003099919,0.00035135384,0.00035422557,0.002198869],"category_scores_gemma":[0.00009813505,0.00024052474,0.0003599392,0.0002113549,0.00017601659,0.00031361255,0.0002882058,0.00045771652,0.0007254142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042674856,0.00011401159,0.00011848966,0.00039304513,0.000029378863,0.00019729369,0.000039768027,0.002365174,0.97336733,0.001977953,0.0004108628,0.020559907],"study_design_scores_gemma":[0.0001196918,0.00063794607,0.00025985276,0.000015313171,0.000032776574,0.000133785,0.000018448925,0.0023165452,0.988274,0.0002818293,0.00788581,0.000024086065],"about_ca_topic_score_codex":0.00076140417,"about_ca_topic_score_gemma":0.0018401992,"teacher_disagreement_score":0.002198869,"about_ca_system_score_codex":0.0004016719,"about_ca_system_score_gemma":0.0004316237,"threshold_uncertainty_score":0.007355988},"labels":[],"label_agreement":null},{"id":"W2011083782","doi":"10.1016/j.bmcl.2015.04.059","title":"Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Genome British Columbia","keywords":"Bioavailability; Prodrug; Neuraminidase inhibitor; Zanamivir; Chemistry; Pharmacokinetics; Neuraminidase; Pharmacology; Oral administration; Oseltamivir; Biochemistry; Medicine; Infectious disease (medical specialty); Enzyme; Coronavirus disease 2019 (COVID-19); Internal medicine","score_opus":0.14418110074738147,"score_gpt":0.38236486130753716,"score_spread":0.2381837605601557,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2011083782","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9830321,0.003564493,0.00923418,0.0001521223,0.000100241276,0.00018593462,0.0012438581,0.00012737984,0.0023598142],"genre_scores_gemma":[0.9827639,0.0026208642,0.0090225795,0.00008022184,0.00003158578,0.00013800945,0.001224263,0.000025185118,0.0040934295],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99965894,0.00008164939,0.000027378086,0.00006423376,0.00011686292,0.000050904808],"domain_scores_gemma":[0.99969196,0.000098206554,0.000055946217,0.000032464955,0.000085308195,0.000036228197],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006710265,0.00055620045,0.00056966353,0.00025915503,0.0001697764,0.00049426674,0.00024627347,0.00046403875,0.001141278],"category_scores_gemma":[0.000823722,0.00024636247,0.00028447618,0.00028761372,0.00023353075,0.00038901003,0.00021540467,0.00082217436,0.00035956607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0027724677,0.00020665355,0.0013785651,0.00012041334,0.00005159844,0.00009812191,0.000069286514,0.000802728,0.9816031,0.00011045007,0.00029756746,0.012489034],"study_design_scores_gemma":[0.00013379799,0.00654551,0.0035511905,0.000012482118,0.000089535475,0.00035605684,0.000061138424,0.002494472,0.9851864,0.000064849475,0.001479928,0.000024706158],"about_ca_topic_score_codex":0.0012196754,"about_ca_topic_score_gemma":0.0014409045,"teacher_disagreement_score":0.0012196754,"about_ca_system_score_codex":0.00035483175,"about_ca_system_score_gemma":0.0004743372,"threshold_uncertainty_score":0.0038179755},"labels":[],"label_agreement":null},{"id":"W2011384588","doi":"10.1016/j.bmcl.2010.01.014","title":"Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Pharmacophore; Prodrug; Stereochemistry; Celecoxib; Chemical synthesis; In vitro; Biochemistry","score_opus":0.03171185026912064,"score_gpt":0.2998739986268409,"score_spread":0.26816214835772023,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2011384588","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993936,0.002548581,0.00089235493,0.00005712877,0.000049953593,0.00007702958,0.00017072426,0.000027640903,0.0022405505],"genre_scores_gemma":[0.99367684,0.0021009739,0.001474687,0.00006135622,0.000025584253,0.000052140036,0.00038771838,0.000005015662,0.002215736],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999946,0.000011276059,0.000004902544,0.000006700829,0.0000119264305,0.000019258243],"domain_scores_gemma":[0.9999355,0.000013844483,0.000014886998,0.0000070277347,0.0000057472375,0.000022980072],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018936428,0.00021950545,0.00026208136,0.00011094372,0.00013148501,0.00011976143,0.00019772197,0.00019066276,0.0011109281],"category_scores_gemma":[0.00017764619,0.000112702226,0.00012944086,0.00012293409,0.00014581655,0.00017398635,0.00007671892,0.00031719232,0.00019910965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002528065,0.00037881843,0.00018199539,0.0001389042,0.000015089437,0.00023682477,0.000034617104,0.00041262872,0.9852998,0.00023265228,0.00011980139,0.010420917],"study_design_scores_gemma":[0.0014530799,0.015181304,0.0033534672,0.000022881572,0.000096594085,0.0007107602,0.000041575197,0.0011224601,0.9725992,0.00008269035,0.0053183706,0.00001757462],"about_ca_topic_score_codex":0.0003088971,"about_ca_topic_score_gemma":0.00085790356,"teacher_disagreement_score":0.0011109281,"about_ca_system_score_codex":0.00011122877,"about_ca_system_score_gemma":0.00020046461,"threshold_uncertainty_score":0.0037164688},"labels":[],"label_agreement":null},{"id":"W2011681488","doi":"10.1016/j.bmcl.2009.05.029","title":"Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":102,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; Wellcome Trust","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Chemistry; Tyrosine kinase; Receptor tyrosine kinase; Ephrin; EPH receptor A2; Kinase; Receptor Protein-Tyrosine Kinases; Biochemistry; Cell biology; Signal transduction; Biology","score_opus":0.013515889161748873,"score_gpt":0.24185229653723297,"score_spread":0.2283364073754841,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2011681488","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95883644,0.0118642645,0.013241193,0.0009276677,0.00011856997,0.00022869371,0.0011543311,0.00018685134,0.013441954],"genre_scores_gemma":[0.9781345,0.008122656,0.0073133856,0.00017101334,0.000020416255,0.000042703778,0.0011032635,0.000025733554,0.0050663273],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999275,0.000010875945,0.0000043622204,0.000009129825,0.000028060174,0.000020071648],"domain_scores_gemma":[0.9999713,0.0000051181646,0.000008086965,0.0000027896488,0.000005986903,0.000006773125],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566891,0.0003832125,0.00037574777,0.00026726103,0.00022077975,0.00043259087,0.00041923567,0.00018709252,0.0015220983],"category_scores_gemma":[0.00018531743,0.00019890623,0.00026726257,0.00017500778,0.0001494349,0.00025654692,0.00018277849,0.0005064037,0.00028629944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014473049,0.0005671856,0.000916254,0.00035460797,0.00011759443,0.0011413802,0.00011021193,0.02723773,0.8917426,0.012512915,0.0023845257,0.061467703],"study_design_scores_gemma":[0.00038475756,0.0015127282,0.0014227738,0.00003547092,0.00013914591,0.0009972041,0.000069125774,0.023499614,0.9391348,0.0013184708,0.03145009,0.00003575932],"about_ca_topic_score_codex":0.0010498737,"about_ca_topic_score_gemma":0.0021318204,"teacher_disagreement_score":0.0015220983,"about_ca_system_score_codex":0.000587166,"about_ca_system_score_gemma":0.00042062716,"threshold_uncertainty_score":0.0050919056},"labels":[],"label_agreement":null},{"id":"W2012221507","doi":"10.1016/s0960-894x(11)01095-x","title":"Reprint of “Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” [Bioorg. Med. Chem. Lett. 21 (2011) 2591–2596]","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Cytotoxicity; Stereochemistry; Moiety; Steric effects; Carbohydrate; Furan; In vitro; Biochemistry; Organic chemistry","score_opus":0.019900178744270212,"score_gpt":0.20386201799104842,"score_spread":0.1839618392467782,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012221507","genre_codex":"editorial","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.033113234,0.057764493,0.007887848,0.06642296,0.6621872,0.000286939,0.020957926,0.0019323054,0.1494471],"genre_scores_gemma":[0.18700282,0.046603583,0.007559296,0.03732908,0.074709594,0.00028612962,0.029371364,0.0006482902,0.6164899],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99970347,0.000038761613,0.00003838939,0.000036922484,0.00013461101,0.000047737474],"domain_scores_gemma":[0.99936527,0.0002696063,0.00008635762,0.000070767805,0.00012835884,0.00007963956],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030391102,0.000990641,0.0007672778,0.00070865365,0.0005431186,0.00069990294,0.00092236476,0.0012283331,0.06031737],"category_scores_gemma":[0.0014077867,0.0003985735,0.00073378364,0.0005849908,0.00050523784,0.0005771905,0.00027044874,0.0021827538,0.0169661],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019586256,0.00028354843,0.00033204482,0.0014902683,0.00014965804,0.0014435045,0.00007787025,0.0006645306,0.11202926,0.004392545,0.81963325,0.057544854],"study_design_scores_gemma":[0.00019678267,0.00066940987,0.0049034473,0.00007864287,0.00006308932,0.0008813437,0.000039044822,0.00047840129,0.06867315,0.0013804145,0.92259234,0.000043911965],"about_ca_topic_score_codex":0.0014449442,"about_ca_topic_score_gemma":0.0029418028,"teacher_disagreement_score":0.06031737,"about_ca_system_score_codex":0.0004304551,"about_ca_system_score_gemma":0.00039924067,"threshold_uncertainty_score":0.20178169},"labels":[],"label_agreement":null},{"id":"W2012221511","doi":"10.1016/j.bmcl.2010.10.015","title":"Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); McGill University; TransCanada (Canada)","funders":"","keywords":"Chagas disease; Chemistry; Proteases; Trypanosoma cruzi; In vitro; Potency; Biochemistry; Cysteine; Pharmacology; Virology; Enzyme; Biology","score_opus":0.014276313219913692,"score_gpt":0.2743072240897824,"score_spread":0.26003091086986874,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012221511","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93324107,0.034243327,0.014866727,0.0007617185,0.00019083994,0.00057811453,0.0011361105,0.00030005188,0.014682129],"genre_scores_gemma":[0.9697897,0.015687782,0.006249033,0.0002680232,0.000077611054,0.0001152981,0.0012302253,0.000030402725,0.006551938],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999938,0.000009080322,0.0000037689958,0.000009172686,0.000017838054,0.000022081824],"domain_scores_gemma":[0.9999608,0.00000768326,0.000008556441,0.0000039156607,0.000007134189,0.000011943327],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000226175,0.00035963173,0.00043767804,0.00026882274,0.00021859589,0.0003803921,0.0003569247,0.00028142784,0.0023466004],"category_scores_gemma":[0.00015264559,0.00020639454,0.0002143892,0.00015350383,0.00022075596,0.00022251137,0.00021216596,0.0008300664,0.0004196853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006287557,0.00033908137,0.00035674605,0.00029189995,0.00003581596,0.00032878248,0.00005641814,0.0012281112,0.9451173,0.0016623705,0.0010690931,0.048885614],"study_design_scores_gemma":[0.00038697402,0.0027819874,0.0021471255,0.00003534241,0.00010507834,0.0008255638,0.000030263862,0.0020533237,0.9703926,0.00035849144,0.02085727,0.000026154845],"about_ca_topic_score_codex":0.00043326043,"about_ca_topic_score_gemma":0.0017225106,"teacher_disagreement_score":0.0023466004,"about_ca_system_score_codex":0.00028273513,"about_ca_system_score_gemma":0.000307697,"threshold_uncertainty_score":0.00785017},"labels":[],"label_agreement":null},{"id":"W2012250634","doi":"10.1016/s0960-894x(02)00104-x","title":"Stereoselective synthesis of a C-glycoside analogue of N-Fmoc-serine β-N-acetylglucosaminide by ramberg–bäcklund rearrangement","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; Canadian Bee Research Fund","keywords":"Chemistry; Stereoselectivity; Stereochemistry; Glycoside; Serine; Thio-; Derivative (finance); Sulfone; Chemical synthesis; Organic chemistry; Biochemistry; Enzyme; In vitro","score_opus":0.01047474883268163,"score_gpt":0.1888470397209446,"score_spread":0.17837229088826298,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012250634","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9755358,0.001360394,0.010410543,0.00022979866,0.00020670691,0.00014410293,0.0006499224,0.00016910858,0.0112937065],"genre_scores_gemma":[0.9899019,0.00075286214,0.0056829904,0.000061573635,0.000018229064,0.000027330483,0.00040471347,0.000025627523,0.003124928],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998554,0.000016856988,0.000010732585,0.000033902863,0.000024102002,0.000059020833],"domain_scores_gemma":[0.99993706,0.000005547753,0.0000158219,0.000008792192,0.000007898637,0.000024926383],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017122997,0.0004933658,0.0003587455,0.00019331674,0.00021626076,0.0002661676,0.0005147527,0.00032538152,0.0014139129],"category_scores_gemma":[0.00012668,0.00014009232,0.00025087947,0.00025249348,0.00018846345,0.00026442812,0.00023277603,0.000536589,0.00058756175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002838836,0.00006880973,0.0000995807,0.00006526415,0.000015140596,0.0006199872,0.000057523557,0.00048173117,0.9912497,0.00086354115,0.000162033,0.006032869],"study_design_scores_gemma":[0.000072699855,0.0006029924,0.00067178084,0.000004059883,0.000019684103,0.00045497666,0.000025599611,0.0004935862,0.99265516,0.00014326371,0.0048387414,0.00001751562],"about_ca_topic_score_codex":0.0011026957,"about_ca_topic_score_gemma":0.0010430645,"teacher_disagreement_score":0.0014139129,"about_ca_system_score_codex":0.00041495464,"about_ca_system_score_gemma":0.00048819653,"threshold_uncertainty_score":0.004729986},"labels":[],"label_agreement":null},{"id":"W2012288058","doi":"10.1016/j.bmcl.2008.05.034","title":"1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: A novel series of highly potent revertants of P-glycoprotein associated multidrug resistance","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; P-glycoprotein; Multiple drug resistance; Stereochemistry; Verapamil; Potency; Amine gas treating; Chemical synthesis; Structure–activity relationship; Tertiary amine; Transfection; Aryl; In vitro; Gene; Biochemistry; Antibiotics; Alkyl; Organic chemistry","score_opus":0.01698357699484557,"score_gpt":0.21099580163901255,"score_spread":0.19401222464416698,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012288058","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94982475,0.013887855,0.010755556,0.0004892349,0.00042527483,0.0002720228,0.00091618154,0.0009742736,0.022454765],"genre_scores_gemma":[0.9799917,0.007417568,0.00477464,0.00021499458,0.00011711235,0.00016484488,0.0006158529,0.000075190954,0.006628305],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999043,0.000017094535,0.0000072234134,0.00001692592,0.000019100418,0.000035373],"domain_scores_gemma":[0.99993336,0.00001157063,0.000020787407,0.000007978166,0.0000070447036,0.000019347428],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018515035,0.0005126193,0.000444136,0.00029420387,0.0001833991,0.00018950517,0.00069275225,0.000267813,0.0021963948],"category_scores_gemma":[0.00019726063,0.0001816982,0.00017544371,0.00019235235,0.00024107206,0.00022874516,0.00028439943,0.0008459614,0.00068825996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009940213,0.0004208331,0.0002823787,0.00041657034,0.00003342935,0.00075219595,0.00021693757,0.0014945848,0.93561125,0.0024394365,0.0019922988,0.055346042],"study_design_scores_gemma":[0.0011745918,0.010980086,0.0072511095,0.00006216102,0.00010556234,0.0030944615,0.000105692285,0.003123719,0.91838807,0.00059627113,0.055049606,0.000068645866],"about_ca_topic_score_codex":0.00032771393,"about_ca_topic_score_gemma":0.00077802484,"teacher_disagreement_score":0.0021963948,"about_ca_system_score_codex":0.00025291656,"about_ca_system_score_gemma":0.00018484853,"threshold_uncertainty_score":0.007347703},"labels":[],"label_agreement":null},{"id":"W2012337530","doi":"10.1016/j.bmcl.2003.10.064","title":"Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Drug discovery; Ketone; Combinatorial chemistry; Chemical synthesis; Computational biology; Biochemistry; In vitro; Organic chemistry; Biology","score_opus":0.007376302815855656,"score_gpt":0.2301500669849219,"score_spread":0.22277376416906625,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012337530","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9549645,0.021068355,0.013742612,0.0007250012,0.00029796522,0.00043898958,0.0006719542,0.0002289602,0.00786161],"genre_scores_gemma":[0.9778431,0.009045721,0.008209532,0.0003018346,0.000042771582,0.00008678174,0.00063947943,0.000015365087,0.003815365],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991834,0.000012157924,0.000008814781,0.000011100828,0.00002098118,0.000028628907],"domain_scores_gemma":[0.9999361,0.000010884495,0.000013607605,0.000005038128,0.000011921934,0.000022422848],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030634587,0.0004071782,0.00036002655,0.00026627647,0.00014643632,0.00041770106,0.0004311619,0.0003555757,0.001200193],"category_scores_gemma":[0.00017501898,0.00021669999,0.00021875539,0.00016873093,0.00018038385,0.00031939204,0.00023456506,0.00075304956,0.0003362744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013018859,0.00030951935,0.00031998748,0.00026810306,0.000052174735,0.0005934932,0.00005856096,0.0009817947,0.9514263,0.001161048,0.0007910342,0.04273605],"study_design_scores_gemma":[0.0011970721,0.0036409975,0.0012776303,0.000026040449,0.00009926362,0.0015923636,0.000033986897,0.0019622848,0.9720632,0.00036998608,0.01771291,0.000024287603],"about_ca_topic_score_codex":0.00021110817,"about_ca_topic_score_gemma":0.00063068996,"teacher_disagreement_score":0.001200193,"about_ca_system_score_codex":0.00037922055,"about_ca_system_score_gemma":0.00017975732,"threshold_uncertainty_score":0.004015088},"labels":[],"label_agreement":null},{"id":"W2012357880","doi":"10.1016/j.bmcl.2010.01.083","title":"SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Thiazole; Potency; Pharmacology; Dosing; Metabolic syndrome; Type 2 diabetes; Oral administration; Diabetes mellitus; Internal medicine; Endocrinology; Type 2 Diabetes Mellitus; Stearoyl-CoA Desaturase; Biochemistry; Stereochemistry; In vitro; Medicine","score_opus":0.0035622550739903966,"score_gpt":0.20733176674788725,"score_spread":0.20376951167389687,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012357880","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9763051,0.009481376,0.0035836243,0.00047597117,0.00008370313,0.00025013462,0.0013901476,0.00012279124,0.008307075],"genre_scores_gemma":[0.98271215,0.0075367875,0.0030523844,0.00010866037,0.000021944881,0.00007416428,0.0018216802,0.000014253249,0.0046579405],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999926,0.000014731053,0.000007648946,0.000007836716,0.000020461795,0.000023302566],"domain_scores_gemma":[0.99994695,0.00000915555,0.000011347139,0.0000044670915,0.000011893423,0.000016214282],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020208125,0.00033481218,0.00034808138,0.00024739723,0.00021880274,0.00023467265,0.00036209574,0.00023788803,0.0020687457],"category_scores_gemma":[0.00018556532,0.00014985283,0.00018193449,0.0002979025,0.00014838883,0.00015627564,0.0001379462,0.00048405136,0.0004029968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028818687,0.0006097257,0.0009236951,0.00048169884,0.00006363219,0.0009888302,0.00017622088,0.011315828,0.94277495,0.0012459668,0.0021968859,0.036340784],"study_design_scores_gemma":[0.0016459909,0.012795467,0.0072787493,0.00010565041,0.00025913314,0.0017171954,0.00017706433,0.009918286,0.91635793,0.00035799068,0.049306262,0.000080230086],"about_ca_topic_score_codex":0.0020906446,"about_ca_topic_score_gemma":0.00883685,"teacher_disagreement_score":0.0020906446,"about_ca_system_score_codex":0.0003806019,"about_ca_system_score_gemma":0.00031849014,"threshold_uncertainty_score":0.0069206953},"labels":[],"label_agreement":null},{"id":"W2012370038","doi":"10.1016/j.bmcl.2011.07.090","title":"Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Carbonic anhydrase; Structural isomer; Stereochemistry; Gene isoform; Cytosol; Enzyme; Enzyme inhibitor; Transmembrane protein; Chemical synthesis; Biochemistry; In vitro; Receptor","score_opus":0.008149221378740686,"score_gpt":0.18893032678089355,"score_spread":0.18078110540215286,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012370038","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98270226,0.0025109402,0.005382956,0.00019155019,0.000096089025,0.000052431267,0.0002932721,0.00024619585,0.008524367],"genre_scores_gemma":[0.99024487,0.0018777623,0.0013781352,0.00008691446,0.000021489192,0.000029055696,0.00033132007,0.000036600606,0.0059939045],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986815,0.00002024804,0.00000771439,0.000019779089,0.00003391682,0.000050045943],"domain_scores_gemma":[0.999928,0.000017288567,0.000021324275,0.000009413679,0.000009170844,0.000014813836],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018083797,0.0004168329,0.00022191752,0.00012269856,0.00011125667,0.0001777716,0.0002832583,0.00020545386,0.0016787866],"category_scores_gemma":[0.00015155668,0.00013706536,0.0001884322,0.00013554482,0.00024423163,0.000125409,0.0001157988,0.0004543304,0.0005693693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001302019,0.00001858828,0.00008146009,0.000023389086,0.0000063498956,0.000048063655,0.000013332648,0.00009768771,0.99763525,0.00024271506,0.00011869691,0.001584249],"study_design_scores_gemma":[0.00002493222,0.00034299435,0.0009557242,0.0000024215394,0.000008679859,0.00020640632,0.000012342828,0.00024522553,0.99631566,0.000034045046,0.0018482251,0.0000034141042],"about_ca_topic_score_codex":0.0012471017,"about_ca_topic_score_gemma":0.0034007954,"teacher_disagreement_score":0.0016787866,"about_ca_system_score_codex":0.00031499215,"about_ca_system_score_gemma":0.00035691433,"threshold_uncertainty_score":0.0056161284},"labels":[],"label_agreement":null},{"id":"W2012597729","doi":"10.1016/s0960-894x(03)00619-x","title":"Synthesis and Structure–activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Ryerson University","keywords":"Chemistry; Aryl; Stereochemistry; Chemical synthesis; Stereoselectivity; Molecule; Structure–activity relationship; High-performance liquid chromatography; In vitro; Biochemistry; Organic chemistry","score_opus":0.010128833572744533,"score_gpt":0.22990487145967917,"score_spread":0.21977603788693464,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012597729","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9699827,0.014541568,0.0055927923,0.00025667748,0.00015093248,0.00031727253,0.00074834086,0.00019356931,0.008216303],"genre_scores_gemma":[0.98578334,0.005827536,0.0030055086,0.00009859655,0.000049779715,0.00010217145,0.0006890025,0.000024274766,0.004419761],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988174,0.0000376319,0.000012868159,0.000012092299,0.000018925792,0.000036657235],"domain_scores_gemma":[0.99991345,0.000019598188,0.000024418665,0.000009697432,0.000011953883,0.000020840369],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026066118,0.00034250677,0.0004258271,0.00032490882,0.00018326748,0.00024483644,0.000493733,0.0002688089,0.0021943978],"category_scores_gemma":[0.00026128322,0.00025307699,0.00028158966,0.00021235173,0.00015297606,0.0001676446,0.00016659939,0.00046346668,0.00061348215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011067605,0.00025509868,0.00031365646,0.00016253097,0.000049470487,0.00031104818,0.000079265825,0.0014659712,0.9771424,0.0006917135,0.00035902497,0.018063158],"study_design_scores_gemma":[0.00056581915,0.006843935,0.0028433139,0.000021736552,0.00012946573,0.0005703711,0.000042592535,0.0019460417,0.97477084,0.000101303965,0.012136818,0.000027872728],"about_ca_topic_score_codex":0.00075134897,"about_ca_topic_score_gemma":0.0018592143,"teacher_disagreement_score":0.0021943978,"about_ca_system_score_codex":0.00023464848,"about_ca_system_score_gemma":0.00026699592,"threshold_uncertainty_score":0.0073410273},"labels":[],"label_agreement":null},{"id":"W2012692649","doi":"10.1016/j.bmcl.2008.09.109","title":"Total synthesis and biological evaluation of potent analogues of dictyostatin: Modification of the C2–C6 dienoate region","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institutes of Health; National Cancer Institute; Public Health Agency of Canada; Engineering and Physical Sciences Research Council; AstraZeneca","keywords":"Chemistry; Stereochemistry; In vitro; Cell culture; Chemical synthesis; Apoptosis; Aldehyde; Structure–activity relationship; Biological activity; Microtubule; Cell growth; Cancer cell lines; Biochemistry; Cancer cell; Cancer; Cell biology","score_opus":0.08127503413771431,"score_gpt":0.27616693677943716,"score_spread":0.19489190264172285,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012692649","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98509604,0.0039011172,0.005402783,0.000083866566,0.00006160811,0.00018260583,0.0007949977,0.000055054563,0.004421898],"genre_scores_gemma":[0.98969346,0.0025013294,0.003476447,0.00005088891,0.000015572934,0.00005900954,0.0006697433,0.000016419928,0.0035171297],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991286,0.000013091806,0.0000083622635,0.000014807481,0.000024738436,0.000026110636],"domain_scores_gemma":[0.9999331,0.000008752311,0.00001601625,0.000009011075,0.000012327303,0.00002083903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777021,0.0003707319,0.00030370566,0.00013607513,0.0001309907,0.00017491252,0.00026832928,0.00017869218,0.0016196173],"category_scores_gemma":[0.000096292024,0.00011154773,0.00019897224,0.00013385211,0.00015719266,0.00014961412,0.00021888119,0.00042851715,0.0003367757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025416055,0.00004130253,0.00005217411,0.000054558142,0.000009586595,0.00004670581,0.000010999002,0.00036355396,0.9959253,0.000099890996,0.00004784853,0.0030939446],"study_design_scores_gemma":[0.00007313976,0.0012598195,0.00042761353,0.0000038851626,0.000027061895,0.00013902248,0.000006672792,0.00018720904,0.9948555,0.000019595915,0.0029963558,0.000004112458],"about_ca_topic_score_codex":0.00038483302,"about_ca_topic_score_gemma":0.0009428132,"teacher_disagreement_score":0.0016196173,"about_ca_system_score_codex":0.00023016719,"about_ca_system_score_gemma":0.00022303221,"threshold_uncertainty_score":0.005418122},"labels":[],"label_agreement":null},{"id":"W2012812562","doi":"10.1016/j.bmcl.2009.12.086","title":"Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Substituent; In vivo; PI3K/AKT/mTOR pathway; Morpholine; Selectivity; Potency; Stereochemistry; Pharmacology; Structure–activity relationship; In vitro; Combinatorial chemistry; Biochemistry; Medicinal chemistry; Signal transduction","score_opus":0.003483004923445589,"score_gpt":0.19865586799781385,"score_spread":0.19517286307436826,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2012812562","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.958156,0.017755654,0.009388854,0.00046383127,0.00025350845,0.00037940402,0.0011118411,0.00034498182,0.012145944],"genre_scores_gemma":[0.98381376,0.006577207,0.005487881,0.00013946532,0.000038539296,0.00006580341,0.00054510165,0.000020209956,0.0033120236],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982506,0.000043161508,0.00001584725,0.000025906404,0.000042615884,0.00004735913],"domain_scores_gemma":[0.9999447,0.00000844287,0.0000150939095,0.0000051457046,0.000008943578,0.000017608207],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000334675,0.0005305166,0.00043409577,0.0002861196,0.00022661277,0.00033697978,0.0004422528,0.00028468127,0.0018151376],"category_scores_gemma":[0.00021468027,0.00022366871,0.0001639697,0.00029283098,0.00022574177,0.0002724968,0.00026108924,0.0004551855,0.00040797348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024871887,0.00046088512,0.00059120095,0.00058218016,0.00005069637,0.0009552767,0.00016061935,0.0058149653,0.91108704,0.0043760873,0.002160153,0.07127378],"study_design_scores_gemma":[0.0014848527,0.0065363715,0.0028656875,0.000047019566,0.00016228009,0.0016266258,0.000048152648,0.006354953,0.9433778,0.00041693874,0.037002012,0.00007726237],"about_ca_topic_score_codex":0.0011233798,"about_ca_topic_score_gemma":0.0040230034,"teacher_disagreement_score":0.0018151376,"about_ca_system_score_codex":0.00041793167,"about_ca_system_score_gemma":0.00041402376,"threshold_uncertainty_score":0.006072223},"labels":[],"label_agreement":null},{"id":"W2013198300","doi":"10.1016/j.bmcl.2010.10.024","title":"Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Benzothiophene; Chemistry; Pharmacophore; Stereochemistry; Pharmacology; Organic chemistry","score_opus":0.004549685919277363,"score_gpt":0.22113462136270903,"score_spread":0.21658493544343166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013198300","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9608297,0.011888061,0.013966408,0.00076100347,0.00012933566,0.00022575459,0.00063976634,0.00033816136,0.011221977],"genre_scores_gemma":[0.9826668,0.0068244906,0.003954248,0.00018385645,0.000022875274,0.000044789616,0.00048474528,0.000014993246,0.005803091],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995196,0.000005724041,0.0000028045326,0.0000069512157,0.0000111549425,0.000021257942],"domain_scores_gemma":[0.9999776,0.000002096217,0.0000045663846,0.0000022554166,0.0000037099703,0.0000097851125],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011020574,0.00032951063,0.00031415658,0.00018578397,0.00013743705,0.0002156671,0.00032442503,0.00020550968,0.0011701153],"category_scores_gemma":[0.00007761822,0.0001813375,0.00018337497,0.00013612119,0.00013866984,0.00016748003,0.00024606456,0.00054537953,0.00048526033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004052616,0.00022639436,0.00037248246,0.00019972413,0.00002247413,0.00034158933,0.00003893475,0.00067139236,0.97697884,0.00069386896,0.00080829667,0.019240633],"study_design_scores_gemma":[0.00025170704,0.0023571013,0.0038318702,0.000020528641,0.00008042541,0.0009771967,0.00003078906,0.002492581,0.97483635,0.00014988304,0.014949078,0.0000224722],"about_ca_topic_score_codex":0.00055498537,"about_ca_topic_score_gemma":0.0015568496,"teacher_disagreement_score":0.0011701153,"about_ca_system_score_codex":0.00021841109,"about_ca_system_score_gemma":0.0002838831,"threshold_uncertainty_score":0.0039144754},"labels":[],"label_agreement":null},{"id":"W2013244707","doi":"10.1016/j.bmcl.2013.02.064","title":"Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Canadian Blood Services; University Health Network","funders":"Canadian Blood Services","keywords":"Phagocytosis; Chemistry; Pyrazole; Opsonin; Biochemistry; Platelet; Moiety; In vitro; Pharmacology; Stereochemistry; Cell biology; Immunology; Biology","score_opus":0.008364899601237576,"score_gpt":0.21823263164847947,"score_spread":0.2098677320472419,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013244707","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99679023,0.0011890482,0.0004287654,0.000086670865,0.00003277377,0.000020750027,0.00009011862,0.00003094335,0.0013306272],"genre_scores_gemma":[0.9960317,0.0009207381,0.0003356548,0.000042591717,0.000018245068,0.000009876975,0.00027642513,0.0000055785913,0.002359128],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998363,0.000037796064,0.000011565049,0.000012976846,0.000034482076,0.00006686399],"domain_scores_gemma":[0.9998863,0.000037932037,0.000022823851,0.000016332813,0.00001658679,0.000020142037],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013649344,0.00025204587,0.00022553201,0.00015537803,0.00018273528,0.0001852692,0.00032625315,0.00039447803,0.0025888768],"category_scores_gemma":[0.00025899126,0.0001336974,0.00023307119,0.00017226988,0.00019119143,0.00014898586,0.00014364396,0.0005345497,0.00039189588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011370485,0.00020411017,0.0002652231,0.00006722615,0.000018439318,0.00017426781,0.000056247547,0.00017807256,0.99366343,0.00012859241,0.00028057792,0.0038266631],"study_design_scores_gemma":[0.00012748479,0.0036298567,0.0054432745,0.000009160051,0.00002623649,0.0003828989,0.000043117536,0.0010434777,0.9876653,0.000040088442,0.00158072,0.000008255568],"about_ca_topic_score_codex":0.0019090289,"about_ca_topic_score_gemma":0.0026339316,"teacher_disagreement_score":0.0025888768,"about_ca_system_score_codex":0.00024303418,"about_ca_system_score_gemma":0.00025959595,"threshold_uncertainty_score":0.0086606145},"labels":[],"label_agreement":null},{"id":"W2013263858","doi":"10.1016/j.bmcl.2012.10.131","title":"Hybrid fluorescent conjugates of COX-2 inhibitors: Search for a COX-2 isozyme imaging cancer biomarker","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Conjugate; Fluorophore; Fluorescence; Celecoxib; Arachidonate 5-lipoxygenase; Cyclooxygenase; Biochemistry; Enzyme","score_opus":0.015493270194655117,"score_gpt":0.27631753446354995,"score_spread":0.2608242642688948,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013263858","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94323725,0.011153601,0.03774633,0.0008415182,0.00010076082,0.00012453698,0.0002555255,0.00020083835,0.0063396157],"genre_scores_gemma":[0.9611061,0.0038586662,0.026313253,0.00032755802,0.000050616596,0.00012793261,0.0004020832,0.000038805312,0.0077749533],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998455,0.000047639554,0.000003643715,0.00002932576,0.000027658776,0.000046164547],"domain_scores_gemma":[0.99985886,0.00005040644,0.000023670827,0.000012506442,0.0000225064,0.000031993935],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005641451,0.0004103352,0.0003244065,0.0003660968,0.00021785869,0.00065314013,0.0005690383,0.0008174232,0.0016432522],"category_scores_gemma":[0.00039885798,0.00034414395,0.00027751984,0.00023431516,0.0002383864,0.0006434832,0.00043213667,0.0007883128,0.00046548274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004867972,0.0001377735,0.00029602146,0.00010891175,0.000036108773,0.00015914945,0.00005207355,0.0008308381,0.98661566,0.0011773619,0.00036816814,0.009731089],"study_design_scores_gemma":[0.00008501838,0.0008132023,0.00076077424,0.000015948253,0.00006940229,0.0004433513,0.00003389679,0.0040907543,0.9864395,0.000171532,0.007059159,0.000017494762],"about_ca_topic_score_codex":0.000545161,"about_ca_topic_score_gemma":0.0008343669,"teacher_disagreement_score":0.0016432522,"about_ca_system_score_codex":0.00081689726,"about_ca_system_score_gemma":0.00022857031,"threshold_uncertainty_score":0.0059270263},"labels":[],"label_agreement":null},{"id":"W2013478725","doi":"10.1016/j.bmcl.2009.02.018","title":"Approaches to the simultaneous inactivation of metallo- and serine-β-lactamases","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Helse Nord RHF; National Institute of Allergy and Infectious Diseases; Welch Foundation","keywords":"Chemistry; Serine; Isostere; Stereochemistry; Amide; Dipeptide; Enzyme; Hydrolysis; Active site; Enzyme kinetics; Peptide bond; Hydrogen bond; Molecule; Amino acid; Biochemistry; Organic chemistry","score_opus":0.023016497786819252,"score_gpt":0.21735215567157506,"score_spread":0.19433565788475582,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013478725","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7632948,0.021769566,0.20288858,0.0011596989,0.00048444007,0.00035289675,0.00022877702,0.00061936193,0.009201816],"genre_scores_gemma":[0.95230585,0.008136612,0.034402754,0.0002471007,0.00007835365,0.00016276506,0.0001525398,0.00006222496,0.004451851],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9994186,0.00007274565,0.000058650217,0.00013019692,0.00020708767,0.00011275601],"domain_scores_gemma":[0.99985504,0.000030953386,0.000046941957,0.000030079378,0.000017452792,0.000019588224],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00057393295,0.0007819273,0.00058268424,0.0004017226,0.00027807735,0.00067174534,0.0007157234,0.0007966427,0.00078821444],"category_scores_gemma":[0.00034443673,0.00046363485,0.00057671283,0.0002731221,0.0005543222,0.00064492755,0.0011827395,0.0015697485,0.0003163639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010948621,0.000047900776,0.000064174164,0.00012775502,0.000020870199,0.00008532895,0.000043346987,0.00019591204,0.98799056,0.0014413213,0.00009094036,0.009782361],"study_design_scores_gemma":[0.000028567405,0.0002603463,0.00016153036,0.00000687689,0.000025485453,0.0003322271,0.000013197919,0.0006002084,0.9943364,0.0003147542,0.0039124647,0.00000797406],"about_ca_topic_score_codex":0.00016655825,"about_ca_topic_score_gemma":0.00038937293,"teacher_disagreement_score":0.0007966427,"about_ca_system_score_codex":0.00038426553,"about_ca_system_score_gemma":0.00031272403,"threshold_uncertainty_score":0.003035307},"labels":[],"label_agreement":null},{"id":"W2014193867","doi":"10.1016/j.bmcl.2013.01.072","title":"Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Lipopolysaccharide; Peripheral blood mononuclear cell; Pharmacokinetics; Structure–activity relationship; IC50; Inflammation; In vitro; Stereochemistry; Biochemistry; Internal medicine","score_opus":0.014105418560413484,"score_gpt":0.23433945350255292,"score_spread":0.22023403494213944,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2014193867","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9906866,0.006427391,0.00075991347,0.000112579815,0.000040955398,0.000036264268,0.00026077,0.00003676817,0.0016387714],"genre_scores_gemma":[0.9937172,0.0034824482,0.00072751864,0.00005567994,0.000017447072,0.000021064563,0.00030983976,0.000004804877,0.00166405],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992394,0.00002341803,0.000006162969,0.000009135262,0.0000123897735,0.000024959716],"domain_scores_gemma":[0.99992704,0.000015243697,0.000017624392,0.000004695163,0.000012723183,0.000022660575],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018313926,0.00022102217,0.00024610234,0.00025384885,0.00011223303,0.00015019301,0.00023506318,0.00020165973,0.0021267515],"category_scores_gemma":[0.00013806175,0.00013472607,0.00023607526,0.00021021315,0.00011585215,0.00018184379,0.0000929097,0.00033533416,0.00035593385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0020295372,0.00033973993,0.0003329439,0.00012944387,0.000028276823,0.00010651795,0.000024974446,0.0005321171,0.9900712,0.00012591729,0.00013223707,0.006146981],"study_design_scores_gemma":[0.00041771785,0.014825288,0.007267992,0.000025659236,0.000137935,0.00025773558,0.00002947288,0.001782731,0.97102743,0.000056090157,0.0041520856,0.000019697312],"about_ca_topic_score_codex":0.00048478507,"about_ca_topic_score_gemma":0.0009802562,"teacher_disagreement_score":0.0021267515,"about_ca_system_score_codex":0.0001243957,"about_ca_system_score_gemma":0.00012429633,"threshold_uncertainty_score":0.0071147084},"labels":[],"label_agreement":null},{"id":"W2014415435","doi":"10.1016/j.bmcl.2011.12.104","title":"Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ontario Institute of Technology","funders":"","keywords":"Gene silencing; Small interfering RNA; Chemistry; RNA interference; Luciferase; Cell biology; Molecular biology; RNA; Gene; Biochemistry; Transfection; Biology","score_opus":0.01984897973847071,"score_gpt":0.20995571341616442,"score_spread":0.1901067336776937,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2014415435","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98374313,0.0015487951,0.01032732,0.00009459408,0.000033440363,0.00005006368,0.00036683373,0.00015155354,0.0036841652],"genre_scores_gemma":[0.9929039,0.00061997626,0.0031052267,0.000022993603,0.0000038355543,0.00002951072,0.00041595654,0.000021088752,0.0028775085],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990714,0.00001530955,0.000011303022,0.00001834044,0.000026330814,0.000021500382],"domain_scores_gemma":[0.9999294,0.000020974692,0.000017302034,0.000011298898,0.000011537968,0.000009484648],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021434874,0.0002621953,0.00016748418,0.00012860414,0.00013362359,0.0002688894,0.00021929145,0.00027550047,0.00077109766],"category_scores_gemma":[0.00013027272,0.00011896912,0.00018825961,0.00012802955,0.00015657842,0.00013653953,0.00014710611,0.00031228518,0.00032666896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000014017321,0.0000033461872,0.00001928562,0.000008276839,9.090594e-7,0.000015332042,0.000006066158,0.000023846245,0.99948514,0.0000698143,0.000013313457,0.00034052544],"study_design_scores_gemma":[0.0000030898511,0.000028228918,0.00016875842,4.677799e-7,0.0000026534665,0.000017868393,0.0000023500206,0.00018234712,0.9991153,0.000006055465,0.00047195057,9.876896e-7],"about_ca_topic_score_codex":0.0008133464,"about_ca_topic_score_gemma":0.0018795334,"teacher_disagreement_score":0.0008133464,"about_ca_system_score_codex":0.00030449918,"about_ca_system_score_gemma":0.000212636,"threshold_uncertainty_score":0.0025796294},"labels":[],"label_agreement":null},{"id":"W2014591035","doi":"10.1016/s0960-894x(00)00265-1","title":"Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Chemistry; Human cytomegalovirus; Bioavailability; Orally active; Pharmacology; Oral administration; Cytomegalovirus; Metabolism; In vitro; Biochemistry; Virus; Herpesviridae; Virology; Viral disease","score_opus":0.03543805358384865,"score_gpt":0.3083459152312769,"score_spread":0.27290786164742825,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2014591035","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95897174,0.017593084,0.014248866,0.00037257126,0.00012940013,0.0007400495,0.00092091784,0.00022040647,0.0068029487],"genre_scores_gemma":[0.98125494,0.0072549284,0.0058660405,0.00014813861,0.000025965723,0.00017860171,0.0010689585,0.000025488962,0.0041769873],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998585,0.00003293267,0.00000961674,0.000022858332,0.00003083229,0.000045135188],"domain_scores_gemma":[0.9999298,0.000013054263,0.0000137206935,0.0000071792865,0.000016204931,0.000020080635],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004440975,0.00041706185,0.00047414054,0.0002798943,0.00019748438,0.00037984378,0.0007975263,0.0003110977,0.0017618438],"category_scores_gemma":[0.00022054832,0.00019855172,0.00023885054,0.00016573242,0.00022803285,0.00026018271,0.00022812419,0.0005714973,0.00038258266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017992742,0.0010130218,0.00056328654,0.0003994816,0.000057447825,0.0004263222,0.00015533798,0.0045462074,0.9498938,0.001965302,0.0007735564,0.038406964],"study_design_scores_gemma":[0.0020499069,0.018333131,0.0022419966,0.0000625874,0.00018614218,0.0008933811,0.0001138825,0.004839303,0.9428462,0.00041770661,0.027963987,0.00005188455],"about_ca_topic_score_codex":0.000986556,"about_ca_topic_score_gemma":0.0025397565,"teacher_disagreement_score":0.0017618438,"about_ca_system_score_codex":0.00046184813,"about_ca_system_score_gemma":0.00037493336,"threshold_uncertainty_score":0.0058940053},"labels":[],"label_agreement":null},{"id":"W2015007117","doi":"10.1016/j.bmcl.2010.09.111","title":"Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic acid","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Neuraminic acid; Chemistry; Neuraminidase; Azide; Stereochemistry; Enzyme; Triazole; Cycloaddition; Sialic acid; 1,2,3-Triazole; Alkyne; Chemical synthesis; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry; Catalysis","score_opus":0.00927681013860204,"score_gpt":0.2262927283911052,"score_spread":0.21701591825250316,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2015007117","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99570024,0.0012945528,0.0008963767,0.000060094193,0.000046092257,0.00002758004,0.00020387754,0.0000403281,0.0017309027],"genre_scores_gemma":[0.99710196,0.0005478083,0.00064524106,0.000024704914,0.000007825516,0.000015037943,0.00034915848,0.000007473087,0.0013007034],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998617,0.000024004503,0.000012211944,0.00001613176,0.000026824633,0.00005914934],"domain_scores_gemma":[0.99994373,0.000014665964,0.000012129372,0.0000086196205,0.0000076157744,0.000013139015],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016683165,0.00026699796,0.00023321879,0.00011018272,0.00015051443,0.00016028472,0.00031766167,0.0002730091,0.00083874393],"category_scores_gemma":[0.00013595063,0.00012658039,0.00027543114,0.00016207811,0.0001804771,0.0001058871,0.00013296634,0.0004771299,0.00035239843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004147265,0.0000389884,0.00007341948,0.00002024243,0.0000066609437,0.00008138444,0.0000140624325,0.00011268388,0.99814796,0.000059002927,0.000051849835,0.000979121],"study_design_scores_gemma":[0.000036824535,0.0003797719,0.0007847638,0.0000014446483,0.0000072626412,0.00012673419,0.0000065814734,0.00052591966,0.9974043,0.000009785655,0.0007135488,0.0000030565768],"about_ca_topic_score_codex":0.0028677557,"about_ca_topic_score_gemma":0.0036599385,"teacher_disagreement_score":0.0028677557,"about_ca_system_score_codex":0.00050790276,"about_ca_system_score_gemma":0.00026149233,"threshold_uncertainty_score":0.005702138},"labels":[],"label_agreement":null},{"id":"W2015037490","doi":"10.1016/j.bmcl.2012.10.034","title":"Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Montréal; Boehringer Ingelheim (Canada)","funders":"World Health Organization","keywords":"Capsid; Chemistry; Benzimidazole; Potency; Stereochemistry; Structure–activity relationship; Furan; Human immunodeficiency virus (HIV); Pharmacology; Virology; Biochemistry; In vitro; Organic chemistry; Biology","score_opus":0.007416334076399914,"score_gpt":0.21298971604479036,"score_spread":0.20557338196839045,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2015037490","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99601305,0.00077097147,0.0015018334,0.00004405859,0.00001857546,0.000032450876,0.00009394352,0.000049972317,0.0014751315],"genre_scores_gemma":[0.9974673,0.0003306323,0.0014022548,0.000018278353,0.0000043613422,0.0000138464175,0.0000791003,0.0000068772606,0.00067724823],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999125,0.000012446216,0.0000071872673,0.000015026294,0.000019706158,0.000033240714],"domain_scores_gemma":[0.9999391,0.000007912035,0.000021934069,0.000008977573,0.000006457886,0.000015641212],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018390571,0.00031965188,0.0002425379,0.0001008699,0.00011828611,0.00024134852,0.0003446325,0.00024256726,0.0007115049],"category_scores_gemma":[0.00013564502,0.0001379537,0.0001705936,0.00009783166,0.00015953377,0.00016660208,0.00015886464,0.00029612644,0.00023823192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020303446,0.000050189516,0.0000942397,0.000026222431,0.000004097597,0.00005604275,0.000015506717,0.00040660644,0.9965533,0.00010440858,0.000034800127,0.0024516385],"study_design_scores_gemma":[0.00004607058,0.0005087944,0.0005071207,0.00000295948,0.000008409566,0.00011035508,0.000005131931,0.0007428109,0.9971445,0.00001630181,0.00090156845,0.0000058087885],"about_ca_topic_score_codex":0.0006437546,"about_ca_topic_score_gemma":0.0012505364,"teacher_disagreement_score":0.0007115049,"about_ca_system_score_codex":0.00024725738,"about_ca_system_score_gemma":0.00025879082,"threshold_uncertainty_score":0.0023801923},"labels":[],"label_agreement":null},{"id":"W2015240236","doi":"10.1016/j.bmcl.2007.10.088","title":"Development of dimeric modulators for anti-apoptotic Bcl-2 proteins","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"National Cancer Institute","keywords":"Chemistry; Subfamily; Apoptosis; Cytochrome c; Monomer; Small molecule; Bcl-2 family; Cell biology; Structure–activity relationship; Biochemistry; In vitro; Stereochemistry; Programmed cell death; Biology; Gene; Polymer","score_opus":0.009240567191999132,"score_gpt":0.23431025726989424,"score_spread":0.2250696900778951,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2015240236","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9288819,0.017263742,0.045633636,0.0011158109,0.00054026116,0.0005489428,0.00037954794,0.00069827295,0.0049378076],"genre_scores_gemma":[0.9707517,0.0054531298,0.018330932,0.00041938407,0.000082419305,0.00024355354,0.0006610279,0.000069040856,0.003988834],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998173,0.000055904908,0.000014712633,0.000034470406,0.000045212553,0.000032455777],"domain_scores_gemma":[0.99988115,0.000019994337,0.00002395379,0.000013649525,0.000020293715,0.00004101903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00048708203,0.00052543357,0.0005716003,0.00029394426,0.00024915198,0.00044833013,0.00071133,0.00044083165,0.0017574129],"category_scores_gemma":[0.0003134861,0.00034099142,0.00024918548,0.00018275043,0.00018302334,0.0004538294,0.0003178077,0.0015062009,0.00051870605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043903064,0.00028157697,0.00009934169,0.00008387033,0.000026181799,0.00006470659,0.000037835205,0.00040427677,0.98754835,0.00094010925,0.0004200397,0.009654797],"study_design_scores_gemma":[0.00040039024,0.0013474983,0.00033980387,0.000014594371,0.000053263924,0.00035194715,0.000031002986,0.003373985,0.98309636,0.0002640715,0.0107144425,0.000012755393],"about_ca_topic_score_codex":0.00011842978,"about_ca_topic_score_gemma":0.00025996202,"teacher_disagreement_score":0.0017574129,"about_ca_system_score_codex":0.0003658675,"about_ca_system_score_gemma":0.00016348466,"threshold_uncertainty_score":0.005879104},"labels":[],"label_agreement":null},{"id":"W2015450697","doi":"10.1016/j.bmcl.2011.09.076","title":"The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Centre for Disease Control; University of Victoria","funders":"Canadian Institutes of Health Research; University of Victoria","keywords":"Guanidine; Chemistry; Neuraminidase inhibitor; Neuraminidase; Zanamivir; Potency; Pharmacology; Virology; In vitro; Stereochemistry; Biochemistry; Enzyme; Biology; Medicine","score_opus":0.07936172272707726,"score_gpt":0.3181710828285524,"score_spread":0.23880936010147513,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2015450697","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.991931,0.0027710695,0.0016914356,0.00010536365,0.00007085069,0.000021252208,0.00010007122,0.00004485901,0.0032641368],"genre_scores_gemma":[0.9958092,0.00089550583,0.0011875846,0.000052758052,0.000017848459,0.0000057384254,0.0002099262,0.0000087908375,0.0018127492],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999305,0.000012639742,0.0000042108186,0.000008046087,0.000018282033,0.000026341198],"domain_scores_gemma":[0.99995124,0.000010484489,0.0000072111434,0.000008597272,0.0000071657673,0.000015397494],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020435877,0.00020543995,0.00025945096,0.00009599342,0.0001108124,0.00020558672,0.00032859083,0.0002447671,0.00078164606],"category_scores_gemma":[0.00014306589,0.000123998,0.00010981058,0.00008178328,0.00015259524,0.00023700942,0.00012728956,0.0005360574,0.00028357902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003578794,0.00004279742,0.00010837329,0.000025826015,0.00001139325,0.00009902277,0.000010254341,0.00017021487,0.9941737,0.00025379605,0.00008729492,0.004659367],"study_design_scores_gemma":[0.000048394137,0.0011897761,0.0012566834,0.0000027068281,0.000019904754,0.00048341666,0.00000754225,0.0010003009,0.99273723,0.000051417715,0.0031960686,0.0000066216962],"about_ca_topic_score_codex":0.0003178274,"about_ca_topic_score_gemma":0.00053044024,"teacher_disagreement_score":0.00078164606,"about_ca_system_score_codex":0.0001326734,"about_ca_system_score_gemma":0.00014190114,"threshold_uncertainty_score":0.0026149154},"labels":[],"label_agreement":null},{"id":"W2016146972","doi":"10.1016/j.bmcl.2009.01.040","title":"Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters","year":2009,"lang":"nl","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Syracuse University","keywords":"Polyketide synthase; Chemistry; Thioesterase; Polyketide; Peptide; Thioester; Enzyme; Cyclic peptide; Stereochemistry; ATP synthase; Biochemistry; Biosynthesis","score_opus":0.009475743370051623,"score_gpt":0.22405714039185085,"score_spread":0.21458139702179924,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016146972","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94300747,0.010101677,0.038621467,0.00038902706,0.00028805347,0.00015031248,0.00050633535,0.0006083553,0.006327252],"genre_scores_gemma":[0.9808647,0.003098983,0.009009752,0.00008706551,0.000041092924,0.00004141447,0.00069148914,0.000045603996,0.00611986],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997004,0.000052091786,0.000029046416,0.000058163816,0.00009376145,0.000066423265],"domain_scores_gemma":[0.99969876,0.00008467082,0.000057224413,0.000034649096,0.000050263974,0.00007449519],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00057913736,0.0007076377,0.000347948,0.0002868634,0.00013156176,0.0006402203,0.00020254539,0.00036625421,0.0015128736],"category_scores_gemma":[0.00063242344,0.0002881385,0.0002911765,0.0002088827,0.00023153493,0.0008525383,0.00056183233,0.0007767747,0.0012725494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025171155,0.000024155104,0.00015059898,0.0000560183,0.0000071479267,0.00015399841,0.0000265363,0.00016688589,0.99135065,0.00031142758,0.00011993625,0.007380903],"study_design_scores_gemma":[0.000016400309,0.00010733407,0.0005039946,0.000005280936,0.0000082392435,0.00028994324,0.000015579937,0.0005068715,0.9963523,0.00016415732,0.0020238375,0.000006041818],"about_ca_topic_score_codex":0.0001339263,"about_ca_topic_score_gemma":0.00023797741,"teacher_disagreement_score":0.0015128736,"about_ca_system_score_codex":0.00028662718,"about_ca_system_score_gemma":0.00026507204,"threshold_uncertainty_score":0.00506109},"labels":[],"label_agreement":null},{"id":"W2016340718","doi":"10.1016/j.bmcl.2006.09.088","title":"Estrogen receptor β ligands: Design and synthesis of new 2-phenyl-isoindole-1,3-diones","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Isoindole; Stereochemistry; Estrogen receptor; Combinatorial chemistry; Chemical synthesis; In vitro; Biochemistry; Internal medicine","score_opus":0.005218275304215568,"score_gpt":0.19520877409448675,"score_spread":0.1899904987902712,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016340718","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8048724,0.04529621,0.099065825,0.0018002194,0.0006343166,0.0006494584,0.0018366597,0.000971333,0.044873584],"genre_scores_gemma":[0.915639,0.023579046,0.035500396,0.00081899174,0.00008319394,0.00046303764,0.0011434406,0.000108135835,0.022664752],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999237,0.00001781937,0.000006482641,0.000012809545,0.000013930645,0.000025296955],"domain_scores_gemma":[0.99994016,0.000007894106,0.0000122659285,0.0000041688763,0.00001321855,0.000022274131],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022976485,0.00038601444,0.00026153645,0.0002622233,0.00015483436,0.00030587282,0.0006651436,0.00027343316,0.0024959773],"category_scores_gemma":[0.00016175512,0.00021530344,0.00018284978,0.00020357754,0.00014692779,0.00028171774,0.00026104916,0.0005246976,0.0010646513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004924988,0.0002757096,0.00031195217,0.00065678806,0.000024211995,0.0005719999,0.00023523638,0.0031235868,0.93353903,0.006235733,0.002150648,0.052382495],"study_design_scores_gemma":[0.00034180205,0.0019150624,0.0012691024,0.00009205743,0.000058183894,0.00068873604,0.000119465316,0.004012094,0.9158328,0.0009819755,0.074621715,0.00006697883],"about_ca_topic_score_codex":0.0005266846,"about_ca_topic_score_gemma":0.001724098,"teacher_disagreement_score":0.0024959773,"about_ca_system_score_codex":0.00036562522,"about_ca_system_score_gemma":0.0003510008,"threshold_uncertainty_score":0.0083498955},"labels":[],"label_agreement":null},{"id":"W2016340819","doi":"10.1016/j.bmcl.2014.06.064","title":"Identification of arylsulfonamides as ExoU inhibitors","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Research Foundation of Korea; University of Toronto","keywords":"Cytotoxicity; Chemistry; Virulence factor; Pseudomonas aeruginosa; Virulence; Yeast; Identification (biology); Structure–activity relationship; Sulfonamide; Computational biology; Biochemistry; Stereochemistry; In vitro; Bacteria; Gene; Biology; Genetics","score_opus":0.00436541448757318,"score_gpt":0.207189589653156,"score_spread":0.20282417516558282,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016340819","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9495547,0.019914117,0.014935642,0.0007337193,0.00017294132,0.0003073073,0.0013695145,0.00040446417,0.012607646],"genre_scores_gemma":[0.97405267,0.009871273,0.006217857,0.00023159935,0.000039425224,0.00012607471,0.0015228898,0.000028674665,0.007909459],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998561,0.000026047004,0.000012689478,0.000020764859,0.00004393406,0.000040466697],"domain_scores_gemma":[0.99988186,0.00002477795,0.00002477724,0.000011325515,0.000031516545,0.000025780795],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035962794,0.0005657662,0.00048409472,0.00039107833,0.00018372729,0.0004767744,0.0003807694,0.0003857176,0.0017534004],"category_scores_gemma":[0.00033230887,0.00021350164,0.00025613044,0.0002626632,0.00021365643,0.00033880578,0.00036328085,0.0005364479,0.0005013358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00071443507,0.00026075068,0.00092610036,0.00020129219,0.000038982398,0.00043782257,0.00008102777,0.001230055,0.9542701,0.0014156139,0.0010071811,0.03941659],"study_design_scores_gemma":[0.00020546107,0.0018520883,0.0030668122,0.00003678097,0.000065917586,0.0007428328,0.000062684914,0.002819887,0.9669634,0.00027582652,0.023883231,0.000025081103],"about_ca_topic_score_codex":0.00075659476,"about_ca_topic_score_gemma":0.0017384829,"teacher_disagreement_score":0.0017534004,"about_ca_system_score_codex":0.00051939447,"about_ca_system_score_gemma":0.00033144353,"threshold_uncertainty_score":0.005865693},"labels":[],"label_agreement":null},{"id":"W2016749144","doi":"10.1016/j.bmcl.2012.07.006","title":"Evaluation of siRNAs that contain internal variable-length spacer linkages","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ontario Institute of Technology","funders":"","keywords":"Phosphodiester bond; Sense strand; Sense (electronics); Duplex (building); Small interfering RNA; Chemistry; Gene silencing; RNA interference; RNA; Stereochemistry; Argonaute; Cleavage (geology); Cell biology; DNA; Biology; Biochemistry; Gene","score_opus":0.02899326367498954,"score_gpt":0.27000287953158075,"score_spread":0.2410096158565912,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016749144","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99188954,0.00074985245,0.0048093298,0.00006015774,0.000037953283,0.000115922696,0.00023184683,0.000067162546,0.0020382956],"genre_scores_gemma":[0.9915592,0.00050333334,0.0053054215,0.000048434627,0.0000071489812,0.00006690388,0.00044980948,0.000030778585,0.0020290278],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996997,0.000084305415,0.00003418418,0.00004991754,0.00007586464,0.000055986362],"domain_scores_gemma":[0.9996314,0.00014508556,0.00006954944,0.000030056706,0.000083913204,0.000039989995],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00055427855,0.00040984552,0.0002630963,0.00019198864,0.0002436978,0.00032708686,0.00022102155,0.00043248408,0.0012309338],"category_scores_gemma":[0.0004958407,0.00013279618,0.0002904977,0.0001441753,0.00022609328,0.00019968038,0.00012609128,0.00028918817,0.00025634008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016017885,0.0000398927,0.000069659756,0.00003409595,0.0000061427836,0.000038650698,0.000010294195,0.00020119153,0.9983784,0.0000944757,0.00002312369,0.0009438115],"study_design_scores_gemma":[0.000013385729,0.00034490068,0.00017471032,0.0000010841629,0.000010915845,0.000040655726,0.0000046302175,0.0003952419,0.99863225,0.000009048906,0.00037072998,0.0000024292265],"about_ca_topic_score_codex":0.0007242388,"about_ca_topic_score_gemma":0.0013119114,"teacher_disagreement_score":0.0012309338,"about_ca_system_score_codex":0.00040033317,"about_ca_system_score_gemma":0.00034995552,"threshold_uncertainty_score":0.0041178465},"labels":[],"label_agreement":null},{"id":"W2016754340","doi":"10.1016/j.bmcl.2012.01.124","title":"Discovery of P2X3 selective antagonists for the treatment of chronic pain","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Purinergic receptor; Analgesic; In vivo; Chronic pain; Chemistry; Pharmacology; Antagonist; Receptor; Neuroscience; Medicine; Psychology; Biochemistry","score_opus":0.010131040869797188,"score_gpt":0.24402787930756228,"score_spread":0.2338968384377651,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016754340","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7546416,0.15805723,0.04502491,0.0066023343,0.0011087725,0.0009133292,0.0015432,0.0006485535,0.031460065],"genre_scores_gemma":[0.87692285,0.09020523,0.016009849,0.002221958,0.00044620296,0.0003780476,0.0010097935,0.000070108326,0.012735948],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999075,0.000018844908,0.000006066338,0.000012140505,0.000022657496,0.00003279819],"domain_scores_gemma":[0.99994886,0.000012424148,0.000012668237,0.0000032109472,0.00001050921,0.000012398096],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035490753,0.00049678644,0.0005821988,0.00035993473,0.00023536102,0.0006475405,0.0004445619,0.0005910331,0.0029008246],"category_scores_gemma":[0.0002228031,0.00022932405,0.0003777697,0.00027008617,0.0002480614,0.00037370174,0.00027104735,0.001157256,0.00080556603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001616694,0.00041248745,0.0007329624,0.0007439286,0.00013629095,0.0012403534,0.0001634068,0.0010051952,0.7839075,0.007901588,0.005242634,0.19689699],"study_design_scores_gemma":[0.0045137033,0.013882898,0.01056509,0.00036811063,0.0005355861,0.008749613,0.00022149412,0.008761136,0.740912,0.005921701,0.20542419,0.0001444642],"about_ca_topic_score_codex":0.00038210955,"about_ca_topic_score_gemma":0.0011253613,"teacher_disagreement_score":0.0029008246,"about_ca_system_score_codex":0.00036308434,"about_ca_system_score_gemma":0.000349947,"threshold_uncertainty_score":0.009704292},"labels":[],"label_agreement":null},{"id":"W2017266070","doi":"10.1016/s0960-894x(01)00539-x","title":"The synthesis and properties of new 2-pyrrolylthiones as chelating agents for transition metals and technetium","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Porphyrin and Phthalocyanine Chemistry","field":"Materials Science","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Université de Montréal; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Chelation; Transition metal; Technetium; Chemical synthesis; Combinatorial chemistry; Nuclear chemistry; Organic chemistry; In vitro; Biochemistry; Catalysis","score_opus":0.025221893164379457,"score_gpt":0.23546898872775227,"score_spread":0.21024709556337282,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2017266070","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97731143,0.01154031,0.006707645,0.0001873497,0.00007175231,0.00006329523,0.00028355702,0.00018056358,0.0036540304],"genre_scores_gemma":[0.98179984,0.0039297673,0.0077871783,0.00009079201,0.000035169807,0.000060576862,0.00035011352,0.00005530745,0.005891329],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990857,0.000024757446,0.000009282574,0.000014779935,0.000019525689,0.000023099068],"domain_scores_gemma":[0.9998499,0.000051083887,0.00004072056,0.00002005515,0.00001532876,0.000022800765],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003112054,0.00028279363,0.00021173025,0.00015832779,0.00014470721,0.00034778353,0.00036199755,0.0003176302,0.0011254862],"category_scores_gemma":[0.00033809352,0.00022090923,0.00009955082,0.00016959824,0.0003219521,0.00037906517,0.00016319544,0.00029727546,0.00035326259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038780994,0.000025157899,0.000103241066,0.00016656409,0.0000051103575,0.00010962581,0.000078639474,0.0003902391,0.99126947,0.0005910559,0.00016864856,0.006704501],"study_design_scores_gemma":[0.00003262847,0.0002499145,0.000495823,0.000004647463,0.000009100843,0.00013885649,0.000004846059,0.00071267993,0.9940308,0.000041585896,0.0042705983,0.000008553741],"about_ca_topic_score_codex":0.00046526516,"about_ca_topic_score_gemma":0.00054945407,"teacher_disagreement_score":0.0011254862,"about_ca_system_score_codex":0.0002864548,"about_ca_system_score_gemma":0.00018916973,"threshold_uncertainty_score":0.0037651062},"labels":[],"label_agreement":null},{"id":"W2017496419","doi":"10.1016/j.bmcl.2010.04.015","title":"Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute; National Institute of Mental Health; National Institutes of Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"PKM2; Chemistry; Pyruvate kinase; Biochemistry; Kinase; Cancer cell; Gene isoform; Structure–activity relationship; Enzyme; In vitro; Glycolysis; Cancer; Biology; Gene","score_opus":0.008538137157250611,"score_gpt":0.2289553283962367,"score_spread":0.2204171912389861,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2017496419","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99369484,0.0027349365,0.0011985645,0.000108108296,0.00003257405,0.000108583285,0.0002169063,0.000032733307,0.0018728098],"genre_scores_gemma":[0.995291,0.0018731375,0.0010762162,0.000038596972,0.000010447537,0.000032975946,0.00022403142,0.000005919822,0.0014477889],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986756,0.000047086294,0.000008775347,0.000018148987,0.000021681839,0.000036697817],"domain_scores_gemma":[0.9999064,0.00002870213,0.000015699281,0.000009450644,0.000017676513,0.000022092081],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034539856,0.00021783894,0.0002665986,0.00019588882,0.00018616363,0.0003128168,0.00024873044,0.0002731966,0.0009596312],"category_scores_gemma":[0.00021150569,0.00012307928,0.00014788416,0.00019826036,0.00019647692,0.00016491787,0.00012830735,0.000331545,0.00016751181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022626151,0.00027414915,0.00044151788,0.000131334,0.000019724454,0.00020992958,0.00009812392,0.0011728932,0.987002,0.00039016712,0.00016882703,0.007828749],"study_design_scores_gemma":[0.00055221724,0.009372768,0.0025890963,0.0000106804355,0.00006375138,0.000315901,0.000051108855,0.00198804,0.9804581,0.000086244836,0.0044938773,0.000018249997],"about_ca_topic_score_codex":0.0011912747,"about_ca_topic_score_gemma":0.0024626122,"teacher_disagreement_score":0.0011912747,"about_ca_system_score_codex":0.0002993702,"about_ca_system_score_gemma":0.0003135734,"threshold_uncertainty_score":0.0032103062},"labels":[],"label_agreement":null},{"id":"W2018182922","doi":"10.1016/j.bmcl.2011.01.032","title":"5-Oxo-15-HETE: Total synthesis and bioactivity","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Organic Chemistry Cycloaddition Reactions","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Chemistry; Total synthesis; Chemical synthesis; Stereochemistry; In vitro; Biochemistry","score_opus":0.014522265286449296,"score_gpt":0.19320514046191897,"score_spread":0.17868287517546969,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2018182922","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8694401,0.030900862,0.07906155,0.0004894572,0.0004759544,0.0005045914,0.0039632185,0.00048666136,0.014677656],"genre_scores_gemma":[0.950385,0.012359859,0.016890116,0.00018393231,0.00008057261,0.0001622352,0.0022913418,0.000077027944,0.01756999],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998258,0.000034319713,0.000022668653,0.00003407846,0.000032839107,0.000050271272],"domain_scores_gemma":[0.9999243,0.000012174751,0.0000083515115,0.000017096963,0.000016259331,0.000021908303],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00047209935,0.0006013383,0.0005047173,0.0003960321,0.0002712389,0.0003180414,0.00039163986,0.0003424919,0.0016968602],"category_scores_gemma":[0.00015127615,0.000249534,0.0003664229,0.00028760443,0.00030946927,0.00046582276,0.00044015853,0.00044701176,0.0010838065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011935988,0.00013062544,0.00024955743,0.00020948431,0.000059742208,0.00041270387,0.000069439644,0.00087273057,0.97217685,0.0010732333,0.0002772999,0.02327482],"study_design_scores_gemma":[0.000029250483,0.00049444573,0.00031594833,0.000005508381,0.00003766809,0.00024763664,0.000014271516,0.00015924907,0.99154717,0.0001211205,0.0070182923,0.000009484113],"about_ca_topic_score_codex":0.0006420583,"about_ca_topic_score_gemma":0.0010819043,"teacher_disagreement_score":0.0016968602,"about_ca_system_score_codex":0.00029339662,"about_ca_system_score_gemma":0.0005120602,"threshold_uncertainty_score":0.0056765676},"labels":[],"label_agreement":null},{"id":"W2018371308","doi":"10.1016/j.bmcl.2009.09.069","title":"Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Acadia University; Université Sainte-Anne","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Nova Scotia Health Research Foundation","keywords":"Chemistry; Potency; Conjugate; Cytotoxicity; Pharmacology; Selectivity; In vitro; Topoisomerase; Stereochemistry; Chemical synthesis; Biochemistry; Combinatorial chemistry","score_opus":0.026192558326852224,"score_gpt":0.2722280305617613,"score_spread":0.2460354722349091,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2018371308","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98171496,0.001816448,0.012641385,0.00007311351,0.00003053515,0.0002152831,0.00015063594,0.00013512063,0.0032224988],"genre_scores_gemma":[0.9874979,0.0010458546,0.008756663,0.000025505258,0.000011987717,0.000088773435,0.00017789593,0.000019272218,0.0023761946],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980634,0.000050159237,0.00001834872,0.000029974453,0.00005754889,0.000037635382],"domain_scores_gemma":[0.99986064,0.000017081664,0.000052749223,0.000012193403,0.000028783075,0.00002857494],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042913953,0.00037404263,0.0003368796,0.00018964453,0.00014486625,0.00029669644,0.00034329624,0.00032778704,0.0007774919],"category_scores_gemma":[0.00029459878,0.00021395567,0.00020730631,0.00013778938,0.00015520611,0.00024136507,0.00017821862,0.0002958282,0.00035964267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001592372,0.00006955146,0.00009430355,0.000042872132,0.0000063738207,0.00006136385,0.000024514484,0.0005500591,0.99457765,0.00023324197,0.00003772971,0.0041431603],"study_design_scores_gemma":[0.000023437471,0.0005630865,0.00023186661,0.0000015156913,0.000011253124,0.000051969648,0.000003935418,0.00074941455,0.997326,0.000012511481,0.0010213804,0.0000036141264],"about_ca_topic_score_codex":0.00030782522,"about_ca_topic_score_gemma":0.00058147975,"teacher_disagreement_score":0.0007774919,"about_ca_system_score_codex":0.00031434745,"about_ca_system_score_gemma":0.00022226817,"threshold_uncertainty_score":0.002600968},"labels":[],"label_agreement":null},{"id":"W2018657170","doi":"10.1016/j.bmcl.2013.05.085","title":"Erratum to “Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA” [Bioorg. Med. Chem. Lett. 23 (2013) 2426–2431]","year":2013,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chemistry; Thiourea; Chaperone (clinical); Organic chemistry; Medicine; Nursing","score_opus":0.01857882628369912,"score_gpt":0.27271321155359146,"score_spread":0.25413438526989235,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2018657170","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0009962647,0.0060743717,0.0017593397,0.048069518,0.9287605,0.00006991022,0.0015464083,0.00046345926,0.01226024],"genre_scores_gemma":[0.021863027,0.03730268,0.011842667,0.108021624,0.15887046,0.00028502446,0.009497981,0.0012505034,0.6510661],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9981139,0.00016580119,0.00035902584,0.00020042056,0.00096350524,0.00019737393],"domain_scores_gemma":[0.9960645,0.00093478773,0.0004320115,0.00027427883,0.0019638676,0.00033067813],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016058504,0.0026874652,0.0019892666,0.00326242,0.0032536588,0.0018724691,0.00331533,0.0061107506,0.027627682],"category_scores_gemma":[0.008868974,0.0014663781,0.0016994479,0.0017867193,0.001572257,0.002110232,0.0012173924,0.005193333,0.023694037],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019063771,0.000045542783,0.000116950105,0.00024886001,0.000028373921,0.00095868175,0.000021011996,0.0001438397,0.0014202672,0.00094360183,0.98439723,0.011484992],"study_design_scores_gemma":[0.000063459775,0.0000885312,0.0012102574,0.00015221961,0.000084749234,0.00091715297,0.000046263038,0.0003121354,0.006239959,0.0008172293,0.9900059,0.00006211317],"about_ca_topic_score_codex":0.010146644,"about_ca_topic_score_gemma":0.018096717,"teacher_disagreement_score":0.027627682,"about_ca_system_score_codex":0.0035642919,"about_ca_system_score_gemma":0.003672134,"threshold_uncertainty_score":0.0924238},"labels":[],"label_agreement":null},{"id":"W2018982399","doi":"10.1016/j.bmcl.2009.05.060","title":"Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Royal Victoria Hospital; McGill University","funders":"","keywords":"Chemistry; Moiety; Epidermal growth factor receptor; Epidermal growth factor; Carbamate; Stereochemistry; Receptor; Combinatorial chemistry; Biochemistry; Cancer research; Biology","score_opus":0.035798154736195346,"score_gpt":0.27355459205442656,"score_spread":0.2377564373182312,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2018982399","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9525943,0.0031533672,0.034471795,0.00024446155,0.00014368647,0.0005675003,0.0006650423,0.0004599076,0.007700065],"genre_scores_gemma":[0.96001256,0.0019141925,0.029821863,0.00010496278,0.000026170796,0.00028841037,0.00054306566,0.00006902785,0.007219738],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999362,0.000007378253,0.000007439342,0.000014576502,0.000019488278,0.000014950264],"domain_scores_gemma":[0.9999521,0.000005724085,0.000016878517,0.0000052598743,0.000007987969,0.000012069448],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017505919,0.00030133975,0.00027626273,0.00021482936,0.00015031737,0.00029959748,0.0003222598,0.0003057416,0.0016808705],"category_scores_gemma":[0.00014446373,0.00021371305,0.00022014094,0.00021537613,0.00014006774,0.00027739207,0.00017730605,0.00037718817,0.0005140839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018670826,0.00008602634,0.00010085717,0.00012644715,0.000014387018,0.00010115096,0.000052166964,0.0011822814,0.9872155,0.001219476,0.0002490884,0.009465809],"study_design_scores_gemma":[0.00012986617,0.00067766604,0.00023090202,0.0000044886,0.000016712454,0.000097468714,0.000012688511,0.0029189463,0.98787385,0.00011921645,0.007904693,0.0000134397005],"about_ca_topic_score_codex":0.0001678778,"about_ca_topic_score_gemma":0.0006277011,"teacher_disagreement_score":0.0016808705,"about_ca_system_score_codex":0.00026788708,"about_ca_system_score_gemma":0.00023074112,"threshold_uncertainty_score":0.005623102},"labels":[],"label_agreement":null},{"id":"W2019122388","doi":"10.1016/j.bmcl.2004.05.021","title":"Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Tetrapeptide; Chemistry; Glutamine; Moiety; Pyrrolidine; Stereochemistry; Side chain; Enzyme inhibitor; Ring (chemistry); Structure–activity relationship; Biochemistry; Enzyme; In vitro; Amino acid; Peptide; Organic chemistry","score_opus":0.01732900079354145,"score_gpt":0.2741574883814529,"score_spread":0.25682848758791144,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2019122388","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99494815,0.00057377934,0.0023682262,0.00014279084,0.00009777102,0.00009948901,0.0002351111,0.000114813054,0.001419957],"genre_scores_gemma":[0.9971052,0.00026136098,0.0018054722,0.00007689189,0.000014502306,0.000023150675,0.00015528353,0.000030342542,0.000527739],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976665,0.0000541224,0.00003995225,0.00003421915,0.000054482935,0.000050625076],"domain_scores_gemma":[0.99976474,0.000035750316,0.00008640079,0.000025096555,0.00003388712,0.000054154356],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029755762,0.0005057799,0.00047566768,0.00018773171,0.00027179858,0.00041335946,0.00069527887,0.0005342224,0.0017777127],"category_scores_gemma":[0.00036867696,0.00026926264,0.00039498718,0.00025238423,0.00034555237,0.00024676917,0.00028278204,0.0008488492,0.00054871116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017988994,0.00024109497,0.00032920355,0.00012055432,0.00007225658,0.00072100264,0.000052589596,0.0028852017,0.98703927,0.00066550204,0.00019476113,0.0058797356],"study_design_scores_gemma":[0.0005946536,0.0018573197,0.0011809138,0.00002746382,0.000087337794,0.0007511027,0.00003704804,0.0025097453,0.9891858,0.00020092358,0.0035218385,0.00004580109],"about_ca_topic_score_codex":0.0010524688,"about_ca_topic_score_gemma":0.0013803456,"teacher_disagreement_score":0.0017777127,"about_ca_system_score_codex":0.00046728103,"about_ca_system_score_gemma":0.00040462727,"threshold_uncertainty_score":0.0059470534},"labels":[],"label_agreement":null},{"id":"W2019153783","doi":"10.1016/j.bmcl.2014.10.090","title":"Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Combretastatin; Antimitotic Agent; Chemistry; Colchicine; Cytotoxicity; Tubulin; Stereochemistry; Apoptosis; Combinatorial chemistry; Cell culture; Pharmacology; In vitro; Microtubule; Biochemistry; Cell biology","score_opus":0.011914219504689152,"score_gpt":0.2156706449003204,"score_spread":0.20375642539563124,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2019153783","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9902478,0.0033200376,0.0009358704,0.00014503513,0.00006400743,0.000053325584,0.00043053177,0.000073423784,0.004729971],"genre_scores_gemma":[0.9933154,0.0025468974,0.0012333974,0.000087575034,0.000020321637,0.000019972207,0.00065517303,0.000014208941,0.0021070146],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991024,0.000023702405,0.00000893092,0.0000087873295,0.000023135923,0.000025153575],"domain_scores_gemma":[0.9999583,0.00000376683,0.000010882432,0.0000040014424,0.0000074990558,0.000015635815],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008802515,0.00028226917,0.00028027402,0.00024389818,0.00014555066,0.00022957215,0.0002604838,0.00018329963,0.0015746946],"category_scores_gemma":[0.0001126831,0.000104218205,0.000118749915,0.00019847145,0.00013655437,0.00015651603,0.00014836252,0.00039290983,0.00041381957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008337605,0.00006759555,0.00012242343,0.00006887047,0.000019808478,0.00008675675,0.000015949667,0.00035195026,0.9940805,0.00020848017,0.00018505301,0.0039589023],"study_design_scores_gemma":[0.00042509014,0.0032171535,0.0022591779,0.000011021267,0.00009635256,0.0003873322,0.00004394307,0.0019391652,0.97830814,0.00010126795,0.013187524,0.000023808208],"about_ca_topic_score_codex":0.0020891053,"about_ca_topic_score_gemma":0.0044443756,"teacher_disagreement_score":0.0020891053,"about_ca_system_score_codex":0.0003654806,"about_ca_system_score_gemma":0.00027392295,"threshold_uncertainty_score":0.0052678585},"labels":[],"label_agreement":null},{"id":"W2019169184","doi":"10.1016/j.bmcl.2011.10.040","title":"Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Nicotinic agonist; In vitro; Transporter; Moiety; Biochemistry; Receptor; Stereochemistry; Gene; Medicine","score_opus":0.01943642644165525,"score_gpt":0.22963061233913043,"score_spread":0.21019418589747518,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2019169184","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96481985,0.020613976,0.0023190787,0.0007956586,0.00014679901,0.00022378989,0.0009680339,0.00021110107,0.009901651],"genre_scores_gemma":[0.98330486,0.010787646,0.0015224587,0.0002573254,0.00003306735,0.000059245263,0.0006151372,0.000012503127,0.0034078457],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994135,0.000016707521,0.000004488264,0.0000070419187,0.000009902873,0.0000204545],"domain_scores_gemma":[0.9999293,0.000012040111,0.000012404335,0.0000069859943,0.000010278397,0.000029053343],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034526424,0.00043669142,0.00031233134,0.00028933323,0.0001789976,0.0004171537,0.00035779123,0.00038989182,0.0020935116],"category_scores_gemma":[0.00020005961,0.00014451567,0.00019963126,0.00019337573,0.00017860087,0.0002221004,0.000150128,0.0009082075,0.00038858232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.015856415,0.003490047,0.0013842905,0.00062642054,0.00016808553,0.0005754051,0.00014378518,0.002632542,0.8280341,0.00251105,0.003285389,0.14129253],"study_design_scores_gemma":[0.006579245,0.040153407,0.006536685,0.00013450475,0.0005085464,0.0011061786,0.00012544279,0.0037387793,0.9133045,0.00081291917,0.026939103,0.00006065785],"about_ca_topic_score_codex":0.0011437944,"about_ca_topic_score_gemma":0.0031494473,"teacher_disagreement_score":0.0020935116,"about_ca_system_score_codex":0.00037144867,"about_ca_system_score_gemma":0.00040940446,"threshold_uncertainty_score":0.0070035458},"labels":[],"label_agreement":null},{"id":"W2019455904","doi":"10.1016/j.bmcl.2006.07.064","title":"Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Antibacterial activity; Antibacterial agent; Chemical synthesis; Stereochemistry; Combinatorial chemistry; Structure–activity relationship; Antibiotics; Biochemistry; In vitro; Bacteria","score_opus":0.02925869809743604,"score_gpt":0.2801712545091539,"score_spread":0.2509125564117179,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2019455904","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9918468,0.0044177584,0.00090502907,0.000056682173,0.000025523988,0.000068585505,0.00019052163,0.000020548452,0.002468459],"genre_scores_gemma":[0.99239165,0.0029001087,0.0014708553,0.000036792622,0.000016995698,0.000032156164,0.0003579872,0.0000069305297,0.0027864575],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999229,0.000015417203,0.0000076152664,0.000009887817,0.000016615737,0.000027583628],"domain_scores_gemma":[0.99993765,0.00001589705,0.00001605197,0.0000047978597,0.000011139125,0.000014428316],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015200433,0.00018937168,0.00024344769,0.00021114643,0.00015943126,0.00020851912,0.00021190211,0.00012763048,0.0017346555],"category_scores_gemma":[0.00015366405,0.00012825463,0.00011707464,0.00015671673,0.00017699052,0.00014129624,0.00010126455,0.00020418406,0.00021945585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010095033,0.00029306818,0.00036093462,0.00016053896,0.00001337847,0.00017232748,0.00006510499,0.0007869198,0.98632425,0.000303195,0.00011523535,0.0103954235],"study_design_scores_gemma":[0.00042726315,0.0055091945,0.004334898,0.000015217235,0.000048398615,0.00029253642,0.000037862243,0.00094177225,0.982756,0.000069486545,0.0055532195,0.000014101667],"about_ca_topic_score_codex":0.0012379781,"about_ca_topic_score_gemma":0.0023908608,"teacher_disagreement_score":0.0017346555,"about_ca_system_score_codex":0.00029323358,"about_ca_system_score_gemma":0.00027046216,"threshold_uncertainty_score":0.005802989},"labels":[],"label_agreement":null},{"id":"W2019806050","doi":"10.1016/s0960-894x(00)00554-0","title":"Corrigendum to “Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines” [Bioorg. Med. Chem. Lett. 10 (2000) 439]†","year":2000,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Stereochemistry; Epidermoid carcinoma; Cell culture; In vitro; Colon carcinoma; Combinatorial chemistry; Basal cell; Colorectal cancer; Biochemistry; Cancer; Internal medicine","score_opus":0.009664880534797042,"score_gpt":0.22855187778985542,"score_spread":0.21888699725505836,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2019806050","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00048691634,0.008926822,0.0021309645,0.024726542,0.9488313,0.0001216642,0.0018449412,0.00051273225,0.012418136],"genre_scores_gemma":[0.020238904,0.050484136,0.011603376,0.05334883,0.14032668,0.0005791886,0.010410537,0.0015984254,0.7114098],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99784446,0.00018171687,0.00025357914,0.00037735325,0.0008985182,0.00044426246],"domain_scores_gemma":[0.9957294,0.00073488173,0.0003813767,0.0002798617,0.0023045011,0.00056998915],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0020949736,0.004221463,0.0039728545,0.0028056405,0.003715568,0.0020429096,0.0050749714,0.005046618,0.14542966],"category_scores_gemma":[0.00926249,0.0018990455,0.0028147306,0.0029236944,0.0015040904,0.0024959014,0.0019435495,0.0058439295,0.075228795],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015797494,0.00004152873,0.00007313718,0.0006709435,0.00004464659,0.00058472087,0.000029460442,0.00020401076,0.0021175097,0.0014470194,0.9836374,0.010991752],"study_design_scores_gemma":[0.000103521226,0.00012256094,0.0012869247,0.00016654702,0.000096599746,0.00063559687,0.00004896296,0.00046280914,0.009479704,0.0014062695,0.9860898,0.00010053237],"about_ca_topic_score_codex":0.0096987905,"about_ca_topic_score_gemma":0.012834999,"teacher_disagreement_score":0.14542966,"about_ca_system_score_codex":0.004093334,"about_ca_system_score_gemma":0.0025316856,"threshold_uncertainty_score":0.4865107},"labels":[],"label_agreement":null},{"id":"W2020051213","doi":"10.1016/j.bmcl.2007.11.024","title":"Spermicidal bacteriocins: Lacticin 3147 and subtilosin A","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"University of Alberta","keywords":"Bacteriocin; Antimicrobial; Pony; Spermicide; Chemistry; Traditional medicine; Biology; Microbiology; Medicine; Population; Family planning; Research methodology; Environmental health","score_opus":0.00733129164374127,"score_gpt":0.20933728139633417,"score_spread":0.2020059897525929,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020051213","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99359375,0.0015228563,0.0022415237,0.00018558983,0.000042357475,0.000034054796,0.000112049674,0.000049420367,0.0022183943],"genre_scores_gemma":[0.99391335,0.0007491422,0.0016163179,0.00009998646,0.000014411065,0.000022584649,0.00029443842,0.0000073365263,0.003282298],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993265,0.00001609352,0.0000038514872,0.000007408687,0.000018062105,0.000021951193],"domain_scores_gemma":[0.99993014,0.000007742116,0.000014506188,0.0000023004714,0.000013540739,0.000031706673],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017147865,0.0002871789,0.00012730242,0.00015726208,0.00013441566,0.0002712394,0.000169258,0.00026767823,0.0009117615],"category_scores_gemma":[0.00017124123,0.000072482355,0.00011298652,0.00013408295,0.00016810079,0.00022380099,0.00027581502,0.00026324284,0.00023209589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005822334,0.000060000606,0.00048202742,0.000040773357,0.0000044265707,0.00012930897,0.000018041446,0.00018960676,0.98933357,0.0003476497,0.00018480643,0.00862749],"study_design_scores_gemma":[0.00009547015,0.0016462652,0.0035764847,0.000010552953,0.000013363563,0.00037407211,0.00006699194,0.0009721421,0.98699886,0.00017712888,0.0060602347,0.000008428293],"about_ca_topic_score_codex":0.00031837448,"about_ca_topic_score_gemma":0.00026300026,"teacher_disagreement_score":0.0009117615,"about_ca_system_score_codex":0.0002124927,"about_ca_system_score_gemma":0.00021493096,"threshold_uncertainty_score":0.003050208},"labels":[],"label_agreement":null},{"id":"W2020079633","doi":"10.1016/j.bmcl.2009.05.112","title":"Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McMaster University","keywords":"Smoothened; Chemistry; Aryl; Amide; Hedgehog signaling pathway; Stereochemistry; Hedgehog; Pharmacology; Biochemistry; Signal transduction; Organic chemistry; Alkyl","score_opus":0.01055881176121015,"score_gpt":0.24178458752772622,"score_spread":0.23122577576651607,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020079633","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97566813,0.0050118826,0.0076728063,0.00035460718,0.000115175,0.00024728425,0.00041029233,0.00017631431,0.010343547],"genre_scores_gemma":[0.9858269,0.003066742,0.0061213123,0.00012670114,0.000039997954,0.00009050441,0.00041849696,0.000020927579,0.0042884233],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999076,0.000019809093,0.0000061408673,0.000011623495,0.000024068966,0.000030707793],"domain_scores_gemma":[0.9999429,0.000009148235,0.000015821723,0.0000051662637,0.00001019677,0.00001672392],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031040714,0.00031949254,0.00030862863,0.00019229166,0.00013440053,0.00024164117,0.00040418177,0.00024870815,0.0012196213],"category_scores_gemma":[0.0002084583,0.00021181263,0.0001946529,0.00009883168,0.00015585183,0.00020195279,0.00017618097,0.00047510467,0.00037552198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040937238,0.00010258655,0.00017273906,0.00007657285,0.000016881877,0.00022546122,0.00004193854,0.00066870725,0.988696,0.00056729827,0.00026075583,0.0087617235],"study_design_scores_gemma":[0.00042989498,0.0031270785,0.0022508223,0.000017028917,0.00006517257,0.00055446103,0.000029661847,0.0027917887,0.98014945,0.00014082418,0.01041949,0.000024272427],"about_ca_topic_score_codex":0.0003755576,"about_ca_topic_score_gemma":0.0012488805,"teacher_disagreement_score":0.0012196213,"about_ca_system_score_codex":0.0002693415,"about_ca_system_score_gemma":0.00021152626,"threshold_uncertainty_score":0.004080057},"labels":[],"label_agreement":null},{"id":"W2020116108","doi":"10.1016/j.bmcl.2010.02.040","title":"Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: Dual Inhibitors of cyclooxygenases and 5-lipoxygenase","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Moiety; Stereochemistry; Acetic acid; Substituent; Structural isomer; Docking (animal); Selectivity; Chemical synthesis; Sulfonamide; Enzyme; Enzyme inhibitor; Isozyme; Catalysis; Biochemistry; In vitro","score_opus":0.020665682935918986,"score_gpt":0.2517015743652525,"score_spread":0.2310358914293335,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020116108","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9682427,0.009489905,0.013309857,0.0002655793,0.00013725011,0.0003580271,0.00093078706,0.00018883828,0.0070770886],"genre_scores_gemma":[0.9844105,0.004666694,0.006503292,0.00009398444,0.00004849956,0.00012206948,0.0005320342,0.0000279598,0.0035950467],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978703,0.000047359365,0.000025282643,0.000032503864,0.000040380364,0.000067400324],"domain_scores_gemma":[0.99987507,0.000018585719,0.00003247332,0.000017115126,0.000023817245,0.000032924923],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040677682,0.00048767275,0.00040493615,0.00041097938,0.00020528838,0.00020918365,0.00055092527,0.00039864285,0.0016358793],"category_scores_gemma":[0.00026921672,0.00026576666,0.00035370726,0.00022770457,0.0001928984,0.0002776196,0.00022949882,0.00042565688,0.00062746607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00088859984,0.00018364761,0.00011194882,0.00009436003,0.000019768717,0.00025101294,0.000034974735,0.0005275759,0.9887434,0.00033043837,0.00017279464,0.008641344],"study_design_scores_gemma":[0.0002093363,0.0024118428,0.000562951,0.000008466524,0.00005121652,0.0003278565,0.00001729401,0.00034198363,0.99181455,0.00004290489,0.0041976958,0.000013809885],"about_ca_topic_score_codex":0.0004912847,"about_ca_topic_score_gemma":0.000843881,"teacher_disagreement_score":0.0016358793,"about_ca_system_score_codex":0.00021348718,"about_ca_system_score_gemma":0.00031388324,"threshold_uncertainty_score":0.005472541},"labels":[],"label_agreement":null},{"id":"W2020584459","doi":"10.1016/j.bmcl.2010.06.148","title":"Assessing the ability of a short fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallization","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Recrystallization (geology); Antifreeze; Antifreeze protein; Anomer; Fluorine; Carbohydrate; Glycopeptide; Stereochemistry; Organic chemistry; Biochemistry","score_opus":0.01372616355078433,"score_gpt":0.2489505627853893,"score_spread":0.23522439923460498,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020584459","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9965497,0.0005339609,0.0015623744,0.000042549582,0.000018458131,0.00002787831,0.0001757372,0.000028962742,0.0010603886],"genre_scores_gemma":[0.99414474,0.00040249247,0.0016182368,0.000030507908,0.0000055568194,0.000014296327,0.0006242617,0.00002537636,0.0031345892],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998148,0.000022588021,0.000011696683,0.000033440825,0.000045439676,0.00007210135],"domain_scores_gemma":[0.99971694,0.0000964455,0.000048912432,0.000040018673,0.000053913755,0.000043804703],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002737193,0.00032456394,0.00022141237,0.00009835099,0.000111759815,0.00016256813,0.00030144118,0.0003462787,0.0014201812],"category_scores_gemma":[0.00038323295,0.00014473494,0.00021436019,0.000115377436,0.00025779518,0.0002118809,0.00010818834,0.0004948018,0.00024779383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025132773,0.000040868093,0.00009866052,0.000020061829,0.0000065782237,0.000014292027,0.000012844909,0.000079534635,0.99892753,0.000027051137,0.000022113813,0.00049915485],"study_design_scores_gemma":[0.000008722355,0.00033373781,0.0009570037,0.0000010313436,0.0000040155082,0.000026993617,0.0000046007044,0.0001624256,0.9981895,0.000004168744,0.0003060699,0.000001797457],"about_ca_topic_score_codex":0.003021781,"about_ca_topic_score_gemma":0.0029971544,"teacher_disagreement_score":0.003021781,"about_ca_system_score_codex":0.0002080941,"about_ca_system_score_gemma":0.0002783734,"threshold_uncertainty_score":0.0060083866},"labels":[],"label_agreement":null},{"id":"W2020805901","doi":"10.1016/j.bmcl.2008.12.048","title":"SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103)","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Benzamide; Chemistry; HDAC1; Histone deacetylase; Histone deacetylase inhibitor; In vivo; Small molecule; Acetylation; Pharmacokinetics; In vitro; Lead compound; Recombinant DNA; Cancer research; Histone; Biochemistry; Stereochemistry; Pharmacology","score_opus":0.04702229651429136,"score_gpt":0.2891897136069961,"score_spread":0.24216741709270473,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020805901","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98638886,0.0057959543,0.0018374984,0.00017342395,0.00008117697,0.00022705348,0.0010386679,0.00009005838,0.004367271],"genre_scores_gemma":[0.98970664,0.0037719004,0.0019295211,0.00009312304,0.000021571816,0.00008841787,0.0020496352,0.000014231094,0.0023249255],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999305,0.000014530618,0.000005661383,0.000011953836,0.000014614627,0.000022762431],"domain_scores_gemma":[0.9999074,0.0000150569,0.000017330898,0.0000110963565,0.00001437843,0.00003476345],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022777819,0.00031084273,0.00033047708,0.00016519125,0.00016659875,0.000271617,0.000480078,0.00025246097,0.001985475],"category_scores_gemma":[0.00022144172,0.0001428625,0.00026910278,0.00020038245,0.00021522587,0.0001695431,0.00010739564,0.0006172671,0.00048093378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028007461,0.0010692752,0.00056879566,0.00022734875,0.000050632665,0.00024376332,0.000059550544,0.0029391332,0.975546,0.00042032657,0.0006409649,0.015433485],"study_design_scores_gemma":[0.0025777393,0.028869107,0.006530406,0.00003705025,0.00027562634,0.0011821277,0.000067026405,0.0036438568,0.93994737,0.00014180697,0.016693106,0.000034717767],"about_ca_topic_score_codex":0.0022217468,"about_ca_topic_score_gemma":0.0031826713,"teacher_disagreement_score":0.0022217468,"about_ca_system_score_codex":0.00036394244,"about_ca_system_score_gemma":0.00043499714,"threshold_uncertainty_score":0.0066420436},"labels":[],"label_agreement":null},{"id":"W2021098106","doi":"10.1016/j.bmcl.2007.03.075","title":"Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and pharmacological studies","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; AstraZeneca","keywords":"Chemistry; Chemical synthesis; Stereochemistry; Thrombin; Organic synthesis; Structure–activity relationship; Discovery and development of direct thrombin inhibitors; Enzyme inhibitor; Combinatorial chemistry; In vitro; Biochemistry; Catalysis; Internal medicine","score_opus":0.007718052727960182,"score_gpt":0.23025700216204875,"score_spread":0.22253894943408856,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2021098106","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9791135,0.0018877701,0.011540395,0.0001935013,0.000079188,0.00008417928,0.00038029935,0.00021546215,0.0065056677],"genre_scores_gemma":[0.992423,0.0006827112,0.0044653853,0.000040090315,0.000013301612,0.00002611903,0.00023112886,0.00003042343,0.002087909],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999089,0.000019511885,0.0000072008665,0.000018476107,0.000018126022,0.000027775308],"domain_scores_gemma":[0.99994993,0.000011075461,0.000016032738,0.0000054296243,0.000005461136,0.000012118082],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013753878,0.00033952633,0.0002341903,0.00019515205,0.00018852996,0.0003418488,0.00033681197,0.00032715764,0.0013197126],"category_scores_gemma":[0.00011164915,0.00015670284,0.00022904197,0.00019059768,0.00016056343,0.00025096128,0.00023550467,0.00041272887,0.0003442483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001631568,0.000050460494,0.000067341796,0.000060880033,0.000017898032,0.0002094092,0.000039883635,0.0010381016,0.9935661,0.0008056223,0.000076072974,0.0039049713],"study_design_scores_gemma":[0.000052252,0.00041607607,0.00038146455,0.0000045922357,0.000024921104,0.0002191971,0.000022966937,0.0009291609,0.991514,0.00013149524,0.0062886695,0.000015223653],"about_ca_topic_score_codex":0.00032026408,"about_ca_topic_score_gemma":0.0006257115,"teacher_disagreement_score":0.0013197126,"about_ca_system_score_codex":0.00028319916,"about_ca_system_score_gemma":0.00013285203,"threshold_uncertainty_score":0.0044148564},"labels":[],"label_agreement":null},{"id":"W2021893648","doi":"10.1016/j.bmcl.2004.07.045","title":"N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Nuvo Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Antagonist; Dopamine; Stereochemistry; IC50; Pharmacology; Structure–activity relationship; Dopamine antagonist; In vitro; Internal medicine; Biochemistry; Receptor","score_opus":0.01823149731504961,"score_gpt":0.2682928688331827,"score_spread":0.2500613715181331,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2021893648","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9583133,0.019771572,0.0058284826,0.00035685196,0.00019929389,0.000102479156,0.00044830434,0.00025087182,0.014728873],"genre_scores_gemma":[0.9775219,0.011811748,0.0030134062,0.00016946466,0.00007844651,0.000073260206,0.00043869833,0.0000367288,0.006856427],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983823,0.00005699481,0.000009376548,0.000016649623,0.000032331096,0.00004638323],"domain_scores_gemma":[0.9999423,0.000017152095,0.000012586411,0.000005313669,0.0000068728714,0.0000156754],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028752463,0.0003263197,0.00039001412,0.00018005873,0.00015997996,0.00020469888,0.00040242999,0.00022107046,0.002113004],"category_scores_gemma":[0.00023700805,0.00021927117,0.0001283809,0.00015266014,0.00020406183,0.00015880133,0.00017831346,0.00046359567,0.0005681763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0023714618,0.00022629519,0.00036535866,0.00024088766,0.000038183596,0.000287255,0.00008713797,0.0005144733,0.96428305,0.0013185295,0.0010594713,0.029207947],"study_design_scores_gemma":[0.0010370708,0.006478019,0.004321841,0.00004273077,0.00012413484,0.0012456569,0.000054678356,0.0019476525,0.95405155,0.00026446662,0.030399902,0.00003227574],"about_ca_topic_score_codex":0.00095178495,"about_ca_topic_score_gemma":0.0045330236,"teacher_disagreement_score":0.002113004,"about_ca_system_score_codex":0.00028759317,"about_ca_system_score_gemma":0.0002413653,"threshold_uncertainty_score":0.0070687532},"labels":[],"label_agreement":null},{"id":"W2022388285","doi":"10.1016/j.bmcl.2008.03.005","title":"Synthesis of 17β-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland; College of the North Atlantic; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; MCF-7; Stereochemistry; PEG ratio; Estrone; Chemical synthesis; Ligand (biochemistry); Platinum; Pyridine; Molecule; Combinatorial chemistry; Cancer; Breast cancer; In vitro; Biochemistry; Organic chemistry; Human breast; Internal medicine; Receptor","score_opus":0.03236335677840349,"score_gpt":0.2353923644285082,"score_spread":0.2030290076501047,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022388285","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.982832,0.002136149,0.008523357,0.000100644414,0.00006144834,0.00014847169,0.00056518434,0.00016580742,0.0054668826],"genre_scores_gemma":[0.9875717,0.0010177749,0.0059039695,0.000043961776,0.000009861714,0.00009447409,0.00050655194,0.000025327281,0.00482641],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994135,0.0000071037784,0.000007437507,0.000015605756,0.000013510333,0.000015063287],"domain_scores_gemma":[0.9999521,0.0000102726735,0.00001009618,0.000008388238,0.00000790556,0.000011268237],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010002393,0.00021034367,0.00026641056,0.00014243416,0.0001428087,0.00021628304,0.00022242843,0.0001950261,0.0018781],"category_scores_gemma":[0.000106693675,0.00015606359,0.00015283083,0.00020127343,0.0000866966,0.00013627393,0.00014033391,0.0002081683,0.00041274104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013603136,0.000024277711,0.00011259256,0.0000619381,0.000011997315,0.00010027406,0.00003218011,0.00022787788,0.9948407,0.00022014133,0.00007241374,0.0041596843],"study_design_scores_gemma":[0.000027116503,0.0001745454,0.0004528756,0.0000027530382,0.000017283422,0.00012080945,0.000008604644,0.00022570563,0.9957989,0.000020233541,0.0031485618,0.0000025905722],"about_ca_topic_score_codex":0.00026156488,"about_ca_topic_score_gemma":0.000391638,"teacher_disagreement_score":0.0018781,"about_ca_system_score_codex":0.00013702485,"about_ca_system_score_gemma":0.000096610434,"threshold_uncertainty_score":0.0062829256},"labels":[],"label_agreement":null},{"id":"W2022486716","doi":"10.1016/j.bmcl.2007.01.023","title":"N-Phenyl-N′-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N′-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"","keywords":"Chemistry; Combretastatin; Pharmacophore; Moiety; Stereochemistry; Tubulin; Urea; Colchicine; Cell growth; Chemical synthesis; Microtubule; In vitro; Biochemistry","score_opus":0.02170582358301954,"score_gpt":0.26190269641672603,"score_spread":0.2401968728337065,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022486716","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9924446,0.0020552005,0.0020693757,0.00016551983,0.000035399116,0.000038931008,0.00006791962,0.000044356762,0.003078708],"genre_scores_gemma":[0.99498725,0.00097619137,0.0022376098,0.0001130058,0.000016735557,0.000025604755,0.00009029133,0.000007749051,0.0015456222],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999192,0.000029219713,0.0000042481984,0.000009618359,0.000014467551,0.00002329432],"domain_scores_gemma":[0.9999429,0.00001258924,0.000017674864,0.0000062682648,0.000004934966,0.0000157482],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015489373,0.00014073486,0.00028358013,0.00007360482,0.00009890238,0.00012646806,0.00031798895,0.00026991678,0.0010431062],"category_scores_gemma":[0.00019762303,0.00013525652,0.00011801481,0.00005814287,0.00020826043,0.00025155564,0.00015747154,0.00033594755,0.0003192815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007119135,0.000040695773,0.00013420088,0.000045925637,0.0000068299028,0.00016809526,0.000018673561,0.00034950313,0.99241126,0.00035961586,0.00010157032,0.0056516174],"study_design_scores_gemma":[0.0002468508,0.0018242319,0.0016252109,0.000008596561,0.000021995258,0.00082987704,0.000030533836,0.0016643992,0.9874472,0.000111034984,0.00617753,0.000012420366],"about_ca_topic_score_codex":0.0005283112,"about_ca_topic_score_gemma":0.00091487117,"teacher_disagreement_score":0.0010431062,"about_ca_system_score_codex":0.00020801474,"about_ca_system_score_gemma":0.0001544694,"threshold_uncertainty_score":0.003489554},"labels":[],"label_agreement":null},{"id":"W2022509086","doi":"10.1016/j.bmcl.2008.12.108","title":"Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoylclusters","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Moncton","funders":"","keywords":"Chemistry; Arachidonate 5-lipoxygenase; Lipoxygenase; Caffeic acid; Trimer; Inhibitory postsynaptic potential; Stereochemistry; Tetramer; Biochemistry; Enzyme; Antioxidant; Organic chemistry; Dimer; Arachidonic acid","score_opus":0.010952519814038558,"score_gpt":0.22460429926989883,"score_spread":0.21365177945586028,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022509086","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9858058,0.002273126,0.0069660717,0.0002728373,0.0000844537,0.00008980648,0.00048555408,0.000251222,0.0037710122],"genre_scores_gemma":[0.99209434,0.00088458793,0.0029408645,0.00005365955,0.000013315482,0.000032286447,0.00046946344,0.00002701784,0.003484427],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992454,0.00000716654,0.0000040393875,0.000017549142,0.000014709328,0.000032037868],"domain_scores_gemma":[0.9999362,0.000005034853,0.000009665558,0.000008872212,0.000013591512,0.000026593865],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012562612,0.0003223993,0.00022710203,0.000199605,0.00029649882,0.00023651075,0.0005389341,0.00020674453,0.0015126445],"category_scores_gemma":[0.0001529148,0.00010408502,0.00017963123,0.00023135134,0.00020474709,0.0001887046,0.0002592462,0.00031512912,0.0002573821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028221722,0.000039815117,0.00017945953,0.00012763593,0.000024259496,0.00012613653,0.00011970234,0.00078581925,0.991223,0.0012185513,0.00043911207,0.00543444],"study_design_scores_gemma":[0.000025270823,0.00022820286,0.00070080586,0.0000037020106,0.000019995594,0.00004832112,0.000022152111,0.0005539373,0.9913736,0.000078318255,0.0069330703,0.000012688538],"about_ca_topic_score_codex":0.0036321834,"about_ca_topic_score_gemma":0.006497987,"teacher_disagreement_score":0.0036321834,"about_ca_system_score_codex":0.0007965075,"about_ca_system_score_gemma":0.0004136054,"threshold_uncertainty_score":0.007222116},"labels":[],"label_agreement":null},{"id":"W2022558488","doi":"10.1016/j.bmcl.2006.11.044","title":"A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":147,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Nitrile; Chemistry; Reactivity (psychology); Electrophile; Cysteine; Cathepsin; Proteases; Nitrile hydratase; Combinatorial chemistry; Covalent bond; Stereochemistry; Organic chemistry; Enzyme","score_opus":0.015360790829246298,"score_gpt":0.291482591644595,"score_spread":0.2761218008153487,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022558488","genre_codex":"methods","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":"methods","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.09821165,0.0011523729,0.89158374,0.000106070394,0.00010219074,0.0005620909,0.0021956866,0.0018384185,0.004247844],"genre_scores_gemma":[0.3883826,0.0014044935,0.5999205,0.00014961544,0.000046490724,0.0014525498,0.0019393186,0.0001796867,0.006524768],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99901175,0.00018098079,0.000045097393,0.00027588962,0.00043771445,0.000048507878],"domain_scores_gemma":[0.99881613,0.00044872536,0.0001768524,0.00019891257,0.0002989647,0.000060515536],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013622838,0.0008534709,0.00087002746,0.0014028804,0.0005579702,0.0006423879,0.00083068875,0.0009831983,0.0019434958],"category_scores_gemma":[0.0027170714,0.0003987143,0.0006350109,0.00087546895,0.00035832782,0.0006350321,0.00066808163,0.001172226,0.0009444044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034111686,0.0001505132,0.0058431174,0.00046363537,0.00021066249,0.00015229844,0.00008806669,0.0046218126,0.8554453,0.0019860894,0.001351509,0.12934579],"study_design_scores_gemma":[0.000060686787,0.00075862283,0.011519366,0.000036191937,0.00018619295,0.0010167598,0.00007198931,0.06964236,0.90652394,0.0029553117,0.007122669,0.000105911226],"about_ca_topic_score_codex":0.0007102577,"about_ca_topic_score_gemma":0.0018891601,"teacher_disagreement_score":0.0019434958,"about_ca_system_score_codex":0.00032073527,"about_ca_system_score_gemma":0.00068884203,"threshold_uncertainty_score":0.0072045326},"labels":[],"label_agreement":null},{"id":"W2023018609","doi":"10.1016/j.bmcl.2009.11.111","title":"Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacokinetics; Bioavailability; Potency; Pyridazine; Pharmacology; Enzyme inhibitor; Metabolic stability; Enzyme; Biological activity; Metabolism; Oral administration; Biochemistry; In vitro; Stereochemistry","score_opus":0.009642906465497834,"score_gpt":0.2149618262707206,"score_spread":0.20531891980522277,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2023018609","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96981466,0.010379963,0.009628374,0.0003273953,0.000114455295,0.00034906477,0.0017962216,0.00025524662,0.0073345937],"genre_scores_gemma":[0.9797723,0.0042203865,0.0076122116,0.000100306606,0.0000470159,0.00012044462,0.0017201146,0.0000275196,0.0063796197],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999548,0.0000070188553,0.000005418736,0.000009391585,0.000009664632,0.000013713345],"domain_scores_gemma":[0.9999728,0.000003911334,0.0000054215734,0.0000037594345,0.0000042753327,0.00000988586],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112250375,0.0002668259,0.00027639364,0.00018613257,0.0001701957,0.00020725947,0.00030031355,0.00021869638,0.0017519214],"category_scores_gemma":[0.00009680206,0.00013611393,0.00013933363,0.0001466483,0.00010845555,0.00017322754,0.00012710689,0.00043101824,0.0006505167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011189834,0.00028897115,0.00014992972,0.00017310471,0.000018398516,0.0002703137,0.000030972427,0.00054658216,0.96580607,0.0003462712,0.00048878096,0.030761555],"study_design_scores_gemma":[0.0003273491,0.0021270034,0.00079493475,0.000009380045,0.000044288703,0.000610692,0.000011362809,0.00064571854,0.9816027,0.0000840492,0.013731907,0.000010684372],"about_ca_topic_score_codex":0.00053634285,"about_ca_topic_score_gemma":0.00061531353,"teacher_disagreement_score":0.0017519214,"about_ca_system_score_codex":0.00017202021,"about_ca_system_score_gemma":0.0003439629,"threshold_uncertainty_score":0.0058608055},"labels":[],"label_agreement":null},{"id":"W2023950240","doi":"10.1016/j.bmcl.2006.12.116","title":"Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure–activity relationships","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Steric effects; Stereochemistry; Structure–activity relationship; Structural isomer; Carboxamide; Combinatorial chemistry; In vitro; Biochemistry","score_opus":0.05274759060355945,"score_gpt":0.2928116053385774,"score_spread":0.24006401473501798,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2023950240","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95703983,0.017542133,0.008547277,0.00035621875,0.0001263007,0.00016664664,0.00043871225,0.0002865272,0.01549632],"genre_scores_gemma":[0.98416305,0.007608786,0.003978701,0.00013547127,0.000047525376,0.00006390611,0.00025535762,0.000018658353,0.003728588],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999405,0.0000144362575,0.0000034519378,0.000008629858,0.0000111859,0.000021712929],"domain_scores_gemma":[0.9999417,0.000014501458,0.000015801981,0.0000043084433,0.0000073062633,0.000016325153],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028792734,0.000354156,0.00030016786,0.00017289734,0.00012017325,0.00024339292,0.0002918889,0.00022177388,0.0017881647],"category_scores_gemma":[0.00015577709,0.00015225224,0.00012968671,0.00014591808,0.00016291993,0.00027178848,0.00016033057,0.00042719694,0.00044388798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012202534,0.000356571,0.0003842511,0.00030163897,0.00002292118,0.00043022507,0.00008352441,0.001546771,0.9525934,0.0018686148,0.0006551631,0.040536564],"study_design_scores_gemma":[0.00093906693,0.008847574,0.0062810685,0.000044718458,0.00013569127,0.0011811225,0.00005753568,0.0061226296,0.9509836,0.0005449169,0.02482064,0.000041566705],"about_ca_topic_score_codex":0.00023916729,"about_ca_topic_score_gemma":0.0007014828,"teacher_disagreement_score":0.0017881647,"about_ca_system_score_codex":0.00020685811,"about_ca_system_score_gemma":0.00015707969,"threshold_uncertainty_score":0.0059820414},"labels":[],"label_agreement":null},{"id":"W2024078229","doi":"10.1016/j.bmcl.2012.11.106","title":"The interaction of imidazole-, imidazolium-, and tetrazolium-containing compounds with DNA","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University; University of Toronto","funders":"","keywords":"Chemistry; Bivalent (engine); Imidazole; DNA; Stereochemistry; Base pair; Biochemistry; Organic chemistry","score_opus":0.006538120098743357,"score_gpt":0.2169913886757309,"score_spread":0.21045326857698754,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024078229","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9842258,0.0069129793,0.0042222,0.00023465558,0.000121119665,0.00005458172,0.0001592946,0.000065949105,0.004003423],"genre_scores_gemma":[0.9895976,0.001833782,0.0031336204,0.00012152711,0.000028525257,0.00004440296,0.0002813203,0.000015646987,0.004943478],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996531,0.0001037015,0.000017200644,0.000061736784,0.00006779224,0.00009647467],"domain_scores_gemma":[0.999694,0.00017789137,0.00003961208,0.000019879113,0.00002570964,0.00004296686],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005425794,0.00036851256,0.00037694443,0.00028541315,0.00036058988,0.00049682736,0.00080056133,0.0007568921,0.0017890994],"category_scores_gemma":[0.0007094716,0.00022669294,0.0003182628,0.00025728077,0.00035788998,0.0004173663,0.00020973526,0.00052186305,0.000555937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00041366584,0.000045653745,0.00020154889,0.00012473883,0.0000292412,0.000092814436,0.000069537076,0.00050653605,0.9947325,0.0006006835,0.00012402829,0.003059054],"study_design_scores_gemma":[0.000019051407,0.00027411338,0.000301175,0.0000055121,0.000009997061,0.00006716848,0.000014874866,0.0005685628,0.9970095,0.00004256556,0.0016796086,0.000007844336],"about_ca_topic_score_codex":0.0007738903,"about_ca_topic_score_gemma":0.00088505144,"teacher_disagreement_score":0.0017890994,"about_ca_system_score_codex":0.0007473767,"about_ca_system_score_gemma":0.00029694915,"threshold_uncertainty_score":0.005985141},"labels":[],"label_agreement":null},{"id":"W2024389323","doi":"10.1016/j.bmcl.2005.11.076","title":"Triaminotriazine DNA helicase inhibitors with antibacterial activity","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Cytotoxicity; Helicase; Antibacterial activity; DNA; Antibacterial agent; Pseudomonas aeruginosa; dnaB helicase; Mode of action; Mechanism of action; Antibiotics; Biochemistry; In vitro; Bacteria; RNA; Genetics; Biology; Gene","score_opus":0.005183815270924777,"score_gpt":0.2071175070123641,"score_spread":0.20193369174143933,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024389323","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9417445,0.022829818,0.0066569555,0.00085709966,0.0003977744,0.000321091,0.0010502717,0.00094494474,0.02519758],"genre_scores_gemma":[0.9643873,0.012982038,0.0034131345,0.00044431433,0.00012792196,0.00021213958,0.0018269019,0.000057542977,0.016548743],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998597,0.000020151107,0.000015145427,0.000022153497,0.00003846583,0.000044319393],"domain_scores_gemma":[0.999879,0.00001904693,0.00003063531,0.000016154592,0.000017316464,0.000037878654],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023574146,0.0006386876,0.0005164108,0.000382621,0.00022844263,0.00030603205,0.00049290305,0.00045723727,0.004681107],"category_scores_gemma":[0.00020001632,0.0002704165,0.00025287873,0.000313716,0.00017208683,0.00022945684,0.00025357163,0.0009353315,0.001267536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008115881,0.0001876853,0.0001711086,0.00018313418,0.00004620855,0.0003246866,0.000040036415,0.00053439883,0.9746557,0.0006610821,0.001467541,0.020916821],"study_design_scores_gemma":[0.00060191256,0.0033137854,0.0017145847,0.000027841552,0.00012193252,0.0017689979,0.000019090196,0.0012021437,0.9673082,0.00012937878,0.023765592,0.000026509799],"about_ca_topic_score_codex":0.00075570546,"about_ca_topic_score_gemma":0.0014265915,"teacher_disagreement_score":0.004681107,"about_ca_system_score_codex":0.000303004,"about_ca_system_score_gemma":0.0002546296,"threshold_uncertainty_score":0.015659869},"labels":[],"label_agreement":null},{"id":"W2024724746","doi":"10.1016/j.bmcl.2004.09.015","title":"Biological evaluation of novel estrogen-platinum(II) hybrid molecules on uterine and ovarian cancers—molecular modeling studies","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"College of the North Atlantic; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Estrogen receptor; Cytotoxicity; Molecular model; Estrogen; Biological activity; In vitro; Moiety; Molecule; Ovarian cancer; Estrogen receptor alpha; Stereochemistry; Ligand (biochemistry); Cancer research; Combinatorial chemistry; Biochemistry; Receptor; Cancer; Breast cancer; Internal medicine; Endocrinology; Biology; Organic chemistry","score_opus":0.12848426422914597,"score_gpt":0.3286760942432069,"score_spread":0.2001918300140609,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024724746","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9965886,0.0010947799,0.0013065123,0.00006617855,0.000007252295,0.000016065127,0.00008265964,0.000021861264,0.00081613427],"genre_scores_gemma":[0.9976889,0.00076924585,0.00087141874,0.000014869027,0.0000030800772,0.000013180126,0.000086584194,0.000005083946,0.0005476482],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99994755,0.00001668422,0.0000024824433,0.000008595683,0.000012083514,0.000012663703],"domain_scores_gemma":[0.99995804,0.000019823,0.0000064560004,0.0000033560625,0.000005489288,0.000006842477],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018325665,0.00019018378,0.0002836477,0.00011780086,0.00011630453,0.00022857488,0.00028479015,0.00020986368,0.0008506354],"category_scores_gemma":[0.00018787874,0.00012556049,0.00021901877,0.00013544998,0.000099809746,0.00015432526,0.00009758746,0.00021097095,0.00013249704],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011740498,0.00032339236,0.0015177793,0.00020696153,0.00007606562,0.0002348093,0.00007007661,0.028818728,0.9551083,0.00067173725,0.00021620857,0.0115819],"study_design_scores_gemma":[0.000111895504,0.0018026,0.0016526522,0.0000072240587,0.00011560853,0.0001967693,0.000047973157,0.04019466,0.95390934,0.0000733011,0.0018788566,0.000009117777],"about_ca_topic_score_codex":0.0016227361,"about_ca_topic_score_gemma":0.0013255532,"teacher_disagreement_score":0.0016227361,"about_ca_system_score_codex":0.0002348141,"about_ca_system_score_gemma":0.00010223744,"threshold_uncertainty_score":0.0032265782},"labels":[],"label_agreement":null},{"id":"W2024812969","doi":"10.1016/s0960-894x(00)00517-5","title":"Androsterone 3β-substituted derivatives as inhibitors of type 3 17β-hydroxysteroid dehydrogenase","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Medical Research Council Canada","keywords":"Androsterone; Chemistry; Androstenedione; Dihydrotestosterone; Hydroxysteroid dehydrogenase; Steroid; Dehydrogenase; Testosterone (patch); Androgen; Enzyme; Stereochemistry; Aromatase; Endocrinology; Biochemistry; Internal medicine; Hormone; Biology","score_opus":0.005904387822957843,"score_gpt":0.21755401706054575,"score_spread":0.2116496292375879,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2024812969","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9526132,0.028365588,0.0026337993,0.00032155382,0.00036082795,0.00010659911,0.00088283216,0.00042783818,0.014287874],"genre_scores_gemma":[0.97937757,0.012347729,0.0009777833,0.000103509185,0.00006247074,0.000026342997,0.0006149439,0.000038393075,0.0064513525],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987805,0.000028486516,0.000010232706,0.000011419655,0.000024871179,0.00004692093],"domain_scores_gemma":[0.99992776,0.000014999136,0.000014063292,0.00000946739,0.00000940491,0.000024318315],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017580608,0.00037258177,0.00045432503,0.00037677883,0.00021572532,0.00040541086,0.00042078295,0.00026272406,0.003206169],"category_scores_gemma":[0.00016192225,0.00023649113,0.00028436148,0.00032820323,0.00020520577,0.00021430053,0.00016577824,0.0005853443,0.0009809802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00402695,0.0003351765,0.0006365742,0.00029590027,0.000092189715,0.001024681,0.00016943611,0.0029087625,0.9513929,0.001985144,0.0013623316,0.03576994],"study_design_scores_gemma":[0.00065905275,0.0037821445,0.002579746,0.000031602987,0.0001368993,0.0011500433,0.00006024043,0.001770483,0.9581535,0.00021277356,0.031417828,0.000045640085],"about_ca_topic_score_codex":0.001033333,"about_ca_topic_score_gemma":0.0023351149,"teacher_disagreement_score":0.003206169,"about_ca_system_score_codex":0.00025897103,"about_ca_system_score_gemma":0.00019038192,"threshold_uncertainty_score":0.010725677},"labels":[],"label_agreement":null},{"id":"W2025902121","doi":"10.1016/j.bmcl.2011.02.067","title":"The discovery and synthesis of potent zwitterionic inhibitors of renin","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; hERG; Carboxylic acid; Drug discovery; CYP3A4; Renin inhibitor; Aryl; Renin–angiotensin system; Chemical synthesis; Combinatorial chemistry; Stereochemistry; In vitro; Enzyme; Biochemistry; Organic chemistry; Cytochrome P450","score_opus":0.008114779498595107,"score_gpt":0.1864860764926026,"score_spread":0.1783712969940075,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2025902121","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86109114,0.035874944,0.059306037,0.0025820464,0.0006613484,0.00066070544,0.001329949,0.00054217636,0.037951596],"genre_scores_gemma":[0.9283746,0.03238969,0.01436002,0.0006714532,0.00022619312,0.00016715618,0.001022234,0.00007718162,0.022711465],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991345,0.000013690694,0.000007797346,0.000012927954,0.00002503512,0.00002714941],"domain_scores_gemma":[0.99994004,0.000009471425,0.000017597178,0.0000050409644,0.000008845313,0.00001896381],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035879476,0.00060756266,0.00023126863,0.00030117948,0.0001484194,0.00038003866,0.000529561,0.00029867233,0.00255949],"category_scores_gemma":[0.00025414137,0.00022710745,0.00024016792,0.00020519698,0.00025632346,0.00058578973,0.00048308706,0.00074871833,0.0008568027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004307891,0.00017127895,0.00021891917,0.00035971572,0.000043435353,0.0008578334,0.00015376482,0.0021699045,0.92950994,0.008981062,0.0023663244,0.05473693],"study_design_scores_gemma":[0.00032541534,0.0021675245,0.000790073,0.000030275729,0.000058671732,0.0009894088,0.000053436608,0.0024327964,0.92703766,0.001563349,0.06449597,0.00005534316],"about_ca_topic_score_codex":0.00035243525,"about_ca_topic_score_gemma":0.00086183345,"teacher_disagreement_score":0.00255949,"about_ca_system_score_codex":0.0002823381,"about_ca_system_score_gemma":0.00027275362,"threshold_uncertainty_score":0.008562326},"labels":[],"label_agreement":null},{"id":"W2026071977","doi":"10.1016/j.bmcl.2009.08.085","title":"Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Pharmacokinetics; Phenanthrene; Oral administration; Orally active; Analgesic; Hyperalgesia; In vitro; Stereochemistry; Biochemistry; Nociception; Receptor; Medicine; Organic chemistry","score_opus":0.006813593581799883,"score_gpt":0.23654522395602182,"score_spread":0.22973163037422192,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026071977","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97486997,0.010406046,0.007992814,0.00035808925,0.000109166074,0.00021079328,0.0005424966,0.00016656145,0.005344111],"genre_scores_gemma":[0.98660094,0.0045326906,0.0045319735,0.00010514877,0.00003562431,0.000062768406,0.00047160938,0.000013746163,0.0036455318],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999337,0.000012247603,0.000004584091,0.000009922337,0.000015900248,0.000023735016],"domain_scores_gemma":[0.9999565,0.000008207843,0.000010875597,0.000004718846,0.0000066996345,0.0000130539765],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426672,0.0003093828,0.00028244418,0.00019662366,0.00011338585,0.00025276854,0.0003732446,0.00025164918,0.0012209475],"category_scores_gemma":[0.00017584799,0.00015274633,0.00013730959,0.00014710949,0.00014096426,0.00021693463,0.00018279295,0.00046364343,0.00030661907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006564315,0.000195843,0.0002882766,0.00014638016,0.000021184289,0.00035776186,0.000058082198,0.0010702914,0.9729593,0.0008947912,0.00046792423,0.02288353],"study_design_scores_gemma":[0.0004175687,0.003125975,0.0022887194,0.000019089784,0.00006191741,0.0008912244,0.000027238246,0.0025591236,0.9771236,0.00022681002,0.013240775,0.000017793094],"about_ca_topic_score_codex":0.00022114888,"about_ca_topic_score_gemma":0.0008706329,"teacher_disagreement_score":0.0012209475,"about_ca_system_score_codex":0.00028614825,"about_ca_system_score_gemma":0.00017557708,"threshold_uncertainty_score":0.004084468},"labels":[],"label_agreement":null},{"id":"W2026176076","doi":"10.1016/j.bmcl.2011.06.103","title":"Phosphopeptides with improved cellular uptake properties as ligands for the polo-box domain of polo-like kinase 1","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Bundesministerium für Bildung und Forschung; Alberta Cancer Foundation","keywords":"Phosphopeptide; PLK1; Polo-like kinase; Chemistry; Peptide; Kinase; Biochemistry; Cell; Cell cycle","score_opus":0.010866289501928798,"score_gpt":0.19203989873969127,"score_spread":0.18117360923776246,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026176076","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9913449,0.003159821,0.0032890064,0.000113132446,0.000042617852,0.00002876752,0.00012016317,0.00007850862,0.0018230587],"genre_scores_gemma":[0.9945365,0.0011868668,0.0020706945,0.0001254072,0.000014471004,0.000022517102,0.00020205935,0.000036076235,0.0018054356],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998889,0.000025292022,0.000006831943,0.000020793004,0.000019513262,0.00003868991],"domain_scores_gemma":[0.99988186,0.000040412167,0.000026779473,0.0000070993533,0.000014255889,0.000029442563],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023874556,0.00040147838,0.00031222476,0.00014764011,0.00014469851,0.00041734183,0.00033423078,0.00048095032,0.0011806751],"category_scores_gemma":[0.0003035583,0.00023470934,0.00015399363,0.00016106745,0.00018486194,0.00047210092,0.00031707654,0.00048537718,0.00039674365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003470632,0.000026276186,0.00005615506,0.00006936684,0.000007782455,0.000072426155,0.000030001707,0.0004835076,0.99589515,0.00026778408,0.00007479074,0.0026696709],"study_design_scores_gemma":[0.000057744695,0.00033129123,0.00036412576,0.0000053975377,0.000016459291,0.00018331478,0.000015259915,0.0011210928,0.9957467,0.000057421847,0.002089092,0.000012057124],"about_ca_topic_score_codex":0.0003441474,"about_ca_topic_score_gemma":0.00040265196,"teacher_disagreement_score":0.0011806751,"about_ca_system_score_codex":0.0003561287,"about_ca_system_score_gemma":0.00011552341,"threshold_uncertainty_score":0.0039497614},"labels":[],"label_agreement":null},{"id":"W2026564608","doi":"10.1016/j.bmcl.2011.05.005","title":"Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside β-triphosphates","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of General Medical Sciences; National Institute on Drug Abuse","keywords":"Chemistry; Reverse transcriptase; Nucleoside; Nucleoside Reverse Transcriptase Inhibitor; Reverse-transcriptase inhibitor; Drug; Human immunodeficiency virus (HIV); Virology; Nucleotidyltransferase; Lentivirus; Stereochemistry; Pharmacology; Viral disease; Biochemistry; RNA; Gene","score_opus":0.01667636170259626,"score_gpt":0.2131609807127487,"score_spread":0.19648461901015243,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026564608","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97613657,0.008599046,0.0034657125,0.00024205638,0.00014655918,0.00009480095,0.0003727147,0.00018131382,0.010761403],"genre_scores_gemma":[0.9899595,0.0040427567,0.0016975711,0.00010926096,0.00004029077,0.00005724191,0.0003466139,0.00003094508,0.0037159072],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999892,0.000028207009,0.000013472958,0.000014237692,0.000023426886,0.000028631292],"domain_scores_gemma":[0.9999324,0.000028634335,0.0000125222205,0.000009264583,0.0000062050945,0.000010960631],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019319807,0.00038823634,0.00025121888,0.0002751513,0.00015655917,0.00035495323,0.00030208245,0.00030417944,0.0016496149],"category_scores_gemma":[0.00023629166,0.00023633604,0.000256907,0.00013511795,0.00011488669,0.00023864793,0.00023520464,0.0006498199,0.00054844056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006976238,0.000139235,0.00016799736,0.00014426945,0.000024665425,0.00022331275,0.000052709376,0.0009368835,0.9721265,0.00071634963,0.00037001245,0.024400465],"study_design_scores_gemma":[0.00009011652,0.00081081776,0.00054934435,0.0000134532065,0.000022089605,0.00036265943,0.000011681706,0.0017338727,0.9922429,0.00012326633,0.004032177,0.000007518635],"about_ca_topic_score_codex":0.00045166156,"about_ca_topic_score_gemma":0.00066375645,"teacher_disagreement_score":0.0016496149,"about_ca_system_score_codex":0.0002064392,"about_ca_system_score_gemma":0.00014758944,"threshold_uncertainty_score":0.005518496},"labels":[],"label_agreement":null},{"id":"W2026869349","doi":"10.1016/j.bmcl.2007.07.095","title":"Discovery of potent HIV-1 protease inhibitors incorporating sulfoximine functionality","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ryerson University; University of Minnesota","keywords":"Protease; Chemistry; Moiety; Potency; HIV-1 protease; Stereochemistry; Structure–activity relationship; Enzyme inhibitor; Protease inhibitor (pharmacology); Enzyme; Human immunodeficiency virus (HIV); Biochemistry; In vitro; Virology; Antiretroviral therapy; Viral load; Biology","score_opus":0.011571441025566566,"score_gpt":0.2325556936341822,"score_spread":0.22098425260861562,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026869349","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96899474,0.006856603,0.013573699,0.0003201623,0.000117874726,0.00022896858,0.000393079,0.00020758926,0.0093072895],"genre_scores_gemma":[0.9799027,0.00458596,0.0085638035,0.00014677833,0.00003114663,0.00005813276,0.0004280834,0.000020074056,0.006263361],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999471,0.0000090646745,0.0000035337605,0.0000072406347,0.0000140986385,0.000018995926],"domain_scores_gemma":[0.9999647,0.0000070822234,0.0000092197815,0.000002494711,0.0000052617415,0.000011246876],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021631314,0.00043575122,0.000287154,0.00013537497,0.00011280383,0.00028667419,0.0002743741,0.00022153296,0.0011333411],"category_scores_gemma":[0.00011080575,0.00018398988,0.00016372473,0.00010178812,0.00015317851,0.00021411445,0.00019223246,0.00039188968,0.00032488312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043784123,0.00018998624,0.0003211246,0.00019294496,0.000028476106,0.0003177562,0.00006193484,0.0015877662,0.96926177,0.002026891,0.0007404294,0.024833135],"study_design_scores_gemma":[0.00018238778,0.0017296774,0.0007558834,0.000013680689,0.000032850803,0.0003763923,0.000018670435,0.0023075545,0.98105454,0.00022514928,0.013290006,0.000013207164],"about_ca_topic_score_codex":0.00023349156,"about_ca_topic_score_gemma":0.0007201456,"teacher_disagreement_score":0.0011333411,"about_ca_system_score_codex":0.00022241572,"about_ca_system_score_gemma":0.00018319584,"threshold_uncertainty_score":0.0037914515},"labels":[],"label_agreement":null},{"id":"W2026883608","doi":"10.1016/j.bmcl.2014.09.030","title":"Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Stereochemistry; Amine gas treating; Nucleoside; Cytotoxicity; Potency; Chemical synthesis; Tertiary amine; In vitro; Combinatorial chemistry; Aromatic amine; Structure–activity relationship; Biochemistry; Organic chemistry","score_opus":0.008775690583677987,"score_gpt":0.23579168762609543,"score_spread":0.22701599704241743,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026883608","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94359034,0.030120209,0.0035660865,0.0003431191,0.00012354314,0.00011599076,0.00043095014,0.000197054,0.021512747],"genre_scores_gemma":[0.9819058,0.009848532,0.0027828699,0.000091499845,0.00003598668,0.000037224214,0.0002687853,0.000010807066,0.00501849],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996245,0.000008365884,0.0000024325338,0.000004642119,0.000009003231,0.000013084716],"domain_scores_gemma":[0.99997485,0.0000033107615,0.00000653428,0.0000021006344,0.0000034416491,0.000009738241],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009337671,0.0001950583,0.00017599142,0.00020179879,0.00013180623,0.00015195941,0.00023629301,0.00018038884,0.0022694687],"category_scores_gemma":[0.00007900609,0.0000935069,0.000114681134,0.0001478661,0.00012994988,0.00014781127,0.00014166076,0.00029130813,0.00032608086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011102305,0.00009075031,0.00031191274,0.0002731934,0.000015743863,0.00056007336,0.00007213805,0.0012887517,0.96365464,0.0018950986,0.00056354416,0.030163798],"study_design_scores_gemma":[0.0004529921,0.0054105497,0.0062283208,0.000066224835,0.00011009472,0.0022896405,0.0000671325,0.004553169,0.93057543,0.0005206136,0.049682725,0.00004327944],"about_ca_topic_score_codex":0.0007588508,"about_ca_topic_score_gemma":0.0014893465,"teacher_disagreement_score":0.0022694687,"about_ca_system_score_codex":0.00020028597,"about_ca_system_score_gemma":0.00017090389,"threshold_uncertainty_score":0.0075921416},"labels":[],"label_agreement":null},{"id":"W2027051063","doi":"10.1016/j.bmcl.2009.12.083","title":"The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Bioavailability; Stereochemistry; Epimer; In vivo; Enzyme inhibitor; Pharmacology; Chemical synthesis; Oral administration; Racemization; Cathepsin K; Prodrug; Cathepsin; In vitro; Biochemistry; Enzyme","score_opus":0.005893539419192658,"score_gpt":0.22137483367219904,"score_spread":0.21548129425300638,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2027051063","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9211125,0.04959108,0.010209923,0.0035508473,0.00066514226,0.00020639898,0.0010533818,0.000525852,0.013084994],"genre_scores_gemma":[0.9518511,0.028201854,0.006013658,0.0005826764,0.00016504613,0.000048149763,0.0009188286,0.000032141288,0.012186382],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991906,0.000012666024,0.0000050585427,0.000009549626,0.000025420199,0.000028339924],"domain_scores_gemma":[0.999956,0.000005733324,0.000008658218,0.0000030238639,0.000009412013,0.000017161346],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018780207,0.00037368358,0.00041142173,0.00039065376,0.00018104985,0.00059190945,0.00036579344,0.0004406605,0.0010196626],"category_scores_gemma":[0.00019431225,0.0002057583,0.0002227056,0.00021331322,0.0003127765,0.00030677931,0.00021568993,0.0008217993,0.00049815513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028207751,0.0006221023,0.0010594358,0.00080439827,0.0001374841,0.0019164446,0.000107528904,0.0031129657,0.7823694,0.0072767967,0.010962301,0.18881035],"study_design_scores_gemma":[0.001287102,0.005597953,0.0033803408,0.000047260713,0.00030369146,0.004830512,0.00006128392,0.0052451747,0.86755663,0.0010471412,0.11057435,0.00006863931],"about_ca_topic_score_codex":0.000776165,"about_ca_topic_score_gemma":0.0018701544,"teacher_disagreement_score":0.0010196626,"about_ca_system_score_codex":0.0005954959,"about_ca_system_score_gemma":0.0006657394,"threshold_uncertainty_score":0.0043206215},"labels":[],"label_agreement":null},{"id":"W2027419950","doi":"10.1016/j.bmcl.2011.08.053","title":"Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Stereochemistry; Celecoxib; Pharmacophore; Hydrogen bond; Trifluoromethyl; Cyclooxygenase; Active site; Ibuprofen; Phenyl group; Enzyme; Molecule; Organic chemistry; Biochemistry; Pharmacology","score_opus":0.01616642712972543,"score_gpt":0.2254999813710448,"score_spread":0.20933355424131936,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2027419950","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9711076,0.017301284,0.0018367664,0.00034550412,0.00021827404,0.00014687736,0.00059552933,0.000056996196,0.008391181],"genre_scores_gemma":[0.9837034,0.010828618,0.0014710355,0.00015969212,0.000094623465,0.000049102273,0.0005795014,0.000012288371,0.003101797],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987364,0.00003594409,0.000011478806,0.000010246097,0.000027243306,0.000041393534],"domain_scores_gemma":[0.9999174,0.000013894521,0.000017543895,0.000010668224,0.000011132473,0.000029383467],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025372495,0.00029255528,0.00032548423,0.0003768117,0.00019867593,0.0002577146,0.00027799068,0.0002849401,0.0028869787],"category_scores_gemma":[0.00026998966,0.00016175928,0.00019269252,0.00039917105,0.0001840815,0.00030620335,0.00018796223,0.0007042335,0.00033504496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.014137063,0.0015809688,0.0012228559,0.0004673326,0.00012154525,0.0012320931,0.00021365612,0.002816161,0.88119054,0.0027100982,0.0017339145,0.092573814],"study_design_scores_gemma":[0.004351335,0.04645625,0.009095673,0.00009596071,0.00047292295,0.0022846924,0.0003185252,0.003719288,0.8845208,0.00065476855,0.047948264,0.00008156984],"about_ca_topic_score_codex":0.0007915323,"about_ca_topic_score_gemma":0.0013642808,"teacher_disagreement_score":0.0028869787,"about_ca_system_score_codex":0.00016475127,"about_ca_system_score_gemma":0.00023469054,"threshold_uncertainty_score":0.009657919},"labels":[],"label_agreement":null},{"id":"W2027736455","doi":"10.1016/j.bmcl.2014.06.066","title":"Synthesis and receptor binding in trans-CD ring-fused A-CD estrogens: Comparison with the cis-fused isomers","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Canadian Cancer Society","keywords":"Chemistry; Selectivity; Stereochemistry; Binding affinities; Ring (chemistry); Ligand (biochemistry); Estrogen receptor; Affinities; Binding selectivity; Chemical synthesis; Potency; Cis–trans isomerism; Receptor; In vitro; Biochemistry; Internal medicine","score_opus":0.0058856814835059655,"score_gpt":0.20719567692469668,"score_spread":0.20130999544119071,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2027736455","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98893446,0.0017315666,0.003317004,0.00009715339,0.000036654168,0.000027036964,0.00040208868,0.000046091318,0.0054079704],"genre_scores_gemma":[0.99087673,0.0010094894,0.0026866063,0.000047990292,0.000008084841,0.000010846442,0.0003158202,0.000014215671,0.005030177],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992955,0.0000132390105,0.000005671899,0.000018824774,0.000010025097,0.000022640543],"domain_scores_gemma":[0.99993944,0.000015302949,0.000010464767,0.000010569135,0.000010615664,0.000013558141],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382848,0.00016793385,0.00016874107,0.0001259448,0.00013817856,0.00023492273,0.00021415834,0.00016120927,0.002140467],"category_scores_gemma":[0.00015330767,0.0001115571,0.00015017053,0.00018947101,0.00014070266,0.00016902706,0.00012378242,0.00028364878,0.0005332596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00058544334,0.00006325876,0.00018333462,0.00009765376,0.0000135612245,0.0001115074,0.000053781972,0.00062883104,0.9919653,0.0009896713,0.00015739558,0.005150281],"study_design_scores_gemma":[0.000018965942,0.00029818402,0.0002501914,0.0000030609128,0.000011741167,0.00011878295,0.0000334647,0.00038302614,0.9937768,0.000053133048,0.0050470573,0.0000056515],"about_ca_topic_score_codex":0.0008831174,"about_ca_topic_score_gemma":0.0011183381,"teacher_disagreement_score":0.002140467,"about_ca_system_score_codex":0.00023832166,"about_ca_system_score_gemma":0.00021717096,"threshold_uncertainty_score":0.0071605444},"labels":[],"label_agreement":null},{"id":"W2028124235","doi":"10.1016/j.bmcl.2009.11.062","title":"Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood–brain penetration","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Liver X receptor; Chemistry; Quinoline; Carboxamide; Selectivity; ABCA1; Cytotoxicity; Pharmacology; Biochemistry; Nuclear receptor; In vitro; Gene; Transporter; Biology; Transcription factor","score_opus":0.008890331816144719,"score_gpt":0.23290291032273652,"score_spread":0.22401257850659181,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2028124235","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9811018,0.009369951,0.0036599713,0.0002243666,0.00009633281,0.000089923684,0.0002194919,0.00016165915,0.0050764554],"genre_scores_gemma":[0.9889226,0.004635196,0.0022132017,0.00012174769,0.000037749753,0.000038622304,0.00022528201,0.000018448976,0.0037872195],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999286,0.000023456181,0.000004768267,0.000010334257,0.000011743855,0.000021011412],"domain_scores_gemma":[0.99995005,0.000008617908,0.000014932715,0.0000059959175,0.000008501754,0.000011983198],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022602367,0.00024128132,0.00023067667,0.00013432559,0.00013042634,0.00018972899,0.00031142918,0.00016886435,0.0015163753],"category_scores_gemma":[0.00011633926,0.000110274384,0.00012360679,0.00011866626,0.00017789112,0.00021016426,0.00013566481,0.000275986,0.00032789083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001339646,0.00011139443,0.00027053402,0.00020769266,0.0000142747995,0.00030889828,0.000077958095,0.00067477184,0.97594494,0.0011088384,0.0007722976,0.019168662],"study_design_scores_gemma":[0.00051324524,0.0077196173,0.0034948154,0.000032797845,0.000083610896,0.0012040158,0.0000645814,0.0024449662,0.9574134,0.0002701756,0.026713494,0.000045230434],"about_ca_topic_score_codex":0.0004967755,"about_ca_topic_score_gemma":0.001406053,"teacher_disagreement_score":0.0015163753,"about_ca_system_score_codex":0.00016528799,"about_ca_system_score_gemma":0.00012220535,"threshold_uncertainty_score":0.0050727725},"labels":[],"label_agreement":null},{"id":"W2028413641","doi":"10.1016/j.bmcl.2008.01.004","title":"Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; In vivo; In vitro; Pharmacology; Ovalbumin; IC50; Biological activity; Bronchoconstriction; Pharmacokinetics; Phosphodiesterase; Enzyme inhibitor; Biochemistry; Enzyme; Internal medicine; Immunology; Immune system","score_opus":0.04561154346299345,"score_gpt":0.24923441148438907,"score_spread":0.20362286802139562,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2028413641","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9441833,0.016585942,0.028127382,0.00087821786,0.00017874678,0.0007486151,0.0010702487,0.00032143306,0.0079060905],"genre_scores_gemma":[0.961155,0.008810583,0.021653762,0.00027763704,0.000049562528,0.0002348056,0.0012779101,0.00004559465,0.0064951377],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998203,0.000041811913,0.000017154713,0.00002820789,0.00004981518,0.000042786676],"domain_scores_gemma":[0.99993575,0.000006696091,0.000014265661,0.0000061591522,0.00001852106,0.000018651426],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00051533274,0.00039011973,0.0004097223,0.00025665993,0.00022229106,0.00031927053,0.0007010301,0.00040389659,0.0010724595],"category_scores_gemma":[0.00022564708,0.00020805799,0.00026295485,0.00014590597,0.00016398661,0.0002669748,0.0002098777,0.00051451573,0.00039142318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00058671186,0.00038370944,0.00019401287,0.0001821677,0.00003158414,0.0001764026,0.00006264219,0.0015410339,0.9756197,0.0010968468,0.00045116062,0.019674044],"study_design_scores_gemma":[0.0008609485,0.0047190236,0.0014255635,0.00003086326,0.00013450968,0.0007903748,0.000042252716,0.003784586,0.9630841,0.00027297513,0.024810243,0.000044471413],"about_ca_topic_score_codex":0.00091563247,"about_ca_topic_score_gemma":0.0019650646,"teacher_disagreement_score":0.0010724595,"about_ca_system_score_codex":0.0005047221,"about_ca_system_score_gemma":0.00038485794,"threshold_uncertainty_score":0.0036619902},"labels":[],"label_agreement":null},{"id":"W2029227125","doi":"10.1016/j.bmcl.2010.04.101","title":"C2-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Government of Canada","keywords":"Chemistry; Subtilisin; Moiety; Azobenzene; Protease; Isozyme; Amino acid; In vitro; Peptide; Stereochemistry; Biochemistry; Kexin; Enzyme; Cholesterol; Organic chemistry; Molecule","score_opus":0.0067948927893124395,"score_gpt":0.19897929493978944,"score_spread":0.192184402150477,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2029227125","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9926644,0.0024582362,0.0014300433,0.0000779316,0.000052063173,0.000032715616,0.00010443867,0.00003704804,0.0031431396],"genre_scores_gemma":[0.9959461,0.00094253046,0.00081621425,0.000036929334,0.000015708549,0.000016915965,0.00011538519,0.0000076280403,0.0021026728],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982566,0.0000406877,0.000012088609,0.000022879805,0.000044136563,0.00005469445],"domain_scores_gemma":[0.9999318,0.000019660793,0.000019332829,0.000006123717,0.0000085024185,0.000014629721],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019669604,0.00028578183,0.000248948,0.00018151187,0.00015467351,0.0001767192,0.0002028906,0.00030487683,0.0012973696],"category_scores_gemma":[0.00016018449,0.00013082805,0.0001470409,0.00015736184,0.00016210377,0.00015119612,0.000119562195,0.00034595004,0.00025291802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031359968,0.000030420917,0.00004067804,0.000028689492,0.000005088696,0.00004506738,0.000010761371,0.000109097025,0.99800986,0.00012955445,0.0000437781,0.0012333739],"study_design_scores_gemma":[0.000027590084,0.00047310223,0.0004260538,0.0000014331912,0.0000056123417,0.0000704852,0.0000038053786,0.00022504706,0.9981311,0.000014399515,0.0006187635,0.000002595862],"about_ca_topic_score_codex":0.0005325678,"about_ca_topic_score_gemma":0.0008778843,"teacher_disagreement_score":0.0012973696,"about_ca_system_score_codex":0.00024369455,"about_ca_system_score_gemma":0.00016793962,"threshold_uncertainty_score":0.004340172},"labels":[],"label_agreement":null},{"id":"W2029861563","doi":"10.1016/j.bmcl.2008.03.077","title":"Synthesis and PKCθ inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Reactivity of Heterocycles","field":"Chemistry","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Pyridine; Chemistry; Inhibitory postsynaptic potential; Stereochemistry; Bicyclic molecule; Medicinal chemistry; Internal medicine; Medicine","score_opus":0.014490603849491891,"score_gpt":0.19582239867366727,"score_spread":0.18133179482417539,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2029861563","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9703179,0.00977043,0.005875982,0.0002044615,0.00010850432,0.00023851711,0.0007157008,0.00016751235,0.012600937],"genre_scores_gemma":[0.9809467,0.0077501046,0.004250769,0.00009464526,0.000050475635,0.000170277,0.00089184014,0.000019030269,0.005826031],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991393,0.000015477184,0.000008939331,0.000014031495,0.000018783989,0.00002882862],"domain_scores_gemma":[0.9999242,0.000010876469,0.000020750871,0.000010097496,0.000010553534,0.000023431125],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017797443,0.00038190105,0.00025914639,0.00035739425,0.000265068,0.00018301253,0.0004029434,0.00028035181,0.00233363],"category_scores_gemma":[0.00015010023,0.00015190855,0.00020213214,0.00021016305,0.00017614619,0.00019322828,0.00019802817,0.0004044356,0.0004571026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004767853,0.00020159733,0.00022733111,0.0002851531,0.00002225926,0.0004955814,0.000079864825,0.0015047502,0.97759926,0.0011811922,0.00044040126,0.017485823],"study_design_scores_gemma":[0.00016375715,0.003807134,0.0028047534,0.00003667091,0.000056578814,0.0008039635,0.000041256248,0.0012048113,0.9798514,0.0001540614,0.011044356,0.000031279837],"about_ca_topic_score_codex":0.0007798381,"about_ca_topic_score_gemma":0.0016472114,"teacher_disagreement_score":0.00233363,"about_ca_system_score_codex":0.0002468266,"about_ca_system_score_gemma":0.00041167988,"threshold_uncertainty_score":0.007806778},"labels":[],"label_agreement":null},{"id":"W2029996857","doi":"10.1016/j.bmcl.2009.04.059","title":"Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: Synthesis, biological evaluation and nitric oxide release studies","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Prodrug; Chemistry; Ibuprofen; Nitric oxide; Aspirin; Pharmacology; In vivo; Moiety; Cyclooxygenase; Anti-inflammatory; Stereochemistry; Enzyme; Biochemistry; Organic chemistry; Medicine","score_opus":0.025906656310314927,"score_gpt":0.28545005240609517,"score_spread":0.25954339609578025,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2029996857","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9901805,0.0019966373,0.0033150238,0.0000503408,0.000038968417,0.00007413138,0.00014220856,0.00002400541,0.0041781743],"genre_scores_gemma":[0.9904693,0.001212485,0.0033198353,0.000031086405,0.000009988616,0.000038894894,0.00022938942,0.000010927913,0.0046780803],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993527,0.000016283657,0.0000052991686,0.000008877111,0.000015838405,0.000018490182],"domain_scores_gemma":[0.9999467,0.000013634379,0.000011710885,0.0000065137883,0.000006836829,0.000014676782],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001911661,0.00022561589,0.00015726582,0.00018334543,0.00009612642,0.00008395216,0.0002456888,0.00017575211,0.00073089503],"category_scores_gemma":[0.00015076781,0.00011840042,0.000121942045,0.0000769145,0.00013220753,0.00017043717,0.00010306566,0.00019939539,0.0002015123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000627281,0.00011351667,0.00015203861,0.000072201976,0.0000053991475,0.00023913992,0.000060662143,0.00035628208,0.9901376,0.0005774938,0.00007087701,0.0075874566],"study_design_scores_gemma":[0.00007699487,0.0017814316,0.0008217969,0.0000064202636,0.000016216669,0.00022037607,0.000018273973,0.0004515183,0.9944798,0.00006152914,0.002060874,0.000004760132],"about_ca_topic_score_codex":0.00042143988,"about_ca_topic_score_gemma":0.00094098283,"teacher_disagreement_score":0.00073089503,"about_ca_system_score_codex":0.00016694526,"about_ca_system_score_gemma":0.00016020633,"threshold_uncertainty_score":0.0024451017},"labels":[],"label_agreement":null},{"id":"W2030301626","doi":"10.1016/j.bmcl.2007.06.006","title":"Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Valproic Acid; Histone deacetylase; Trichostatin A; Histone deacetylase inhibitor; Chemistry; Histone deacetylase 5; Histone deacetylase 2; Histone; HDAC10; Acetylation; HDAC11; Chaperone (clinical); Pharmacology; Biochemistry; Cell biology; Cancer research; Epilepsy; Biology; Medicine; Gene; Neuroscience","score_opus":0.008279626108252516,"score_gpt":0.2666140904892953,"score_spread":0.2583344643810428,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030301626","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.985993,0.005411216,0.0032188513,0.00041368764,0.00018042546,0.0000623743,0.0011114446,0.00055461866,0.0030543702],"genre_scores_gemma":[0.9947391,0.0009572667,0.0014799624,0.00007258936,0.000034431327,0.000029529929,0.0009791207,0.0000729787,0.0016351863],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973077,0.000038547456,0.00003181189,0.000049882972,0.000058937603,0.000089972964],"domain_scores_gemma":[0.99975187,0.000041395007,0.000075376454,0.00004675475,0.000026930284,0.000057707657],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016224124,0.00080812786,0.0008334415,0.00033224394,0.00020051013,0.00044970238,0.00033444114,0.0002961702,0.0014961938],"category_scores_gemma":[0.000283133,0.00022554232,0.00043346517,0.0002406674,0.0003321619,0.00024061465,0.0003217815,0.0007032017,0.0006777608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005574591,0.000030979292,0.00008765676,0.000037002406,0.000010824635,0.00010644986,0.0000080902,0.00006475584,0.9973212,0.0000695253,0.000084601095,0.0016214454],"study_design_scores_gemma":[0.00002734844,0.00015386924,0.0012144851,0.0000032253038,0.000007713437,0.00014309879,0.000008281389,0.00023767684,0.9973725,0.000037102156,0.0007912134,0.0000034807294],"about_ca_topic_score_codex":0.00062307145,"about_ca_topic_score_gemma":0.00078626885,"teacher_disagreement_score":0.0014961938,"about_ca_system_score_codex":0.00054409524,"about_ca_system_score_gemma":0.00028204697,"threshold_uncertainty_score":0.0050053},"labels":[],"label_agreement":null},{"id":"W2030329862","doi":"10.1016/j.bmcl.2003.12.025","title":"Kringle 5 peptide–albumin conjugates with anti-migratory activity","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"ConjuChem (Canada)","funders":"","keywords":"Chemistry; Umbilical vein; Conjugate; Peptide; In vitro; Albumin; Bovine serum albumin; Conjugated system; Human serum albumin; Biochemistry; Biological activity; Human umbilical vein endothelial cell; Serum albumin; Organic chemistry","score_opus":0.005019872306314296,"score_gpt":0.1942180873245565,"score_spread":0.18919821501824222,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030329862","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.991401,0.0017043466,0.0041653523,0.00010215269,0.00003956094,0.00002986125,0.00009523476,0.00013116427,0.0023313202],"genre_scores_gemma":[0.99435896,0.00048089438,0.002228738,0.00006778099,0.000014082523,0.000016814596,0.00021274474,0.000021514772,0.0025984438],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997726,0.00003920837,0.000017121029,0.000039006376,0.000039277,0.00009263797],"domain_scores_gemma":[0.9998468,0.000046597954,0.00003860303,0.000016866363,0.00001847133,0.000032655073],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028455566,0.0004413922,0.00031079297,0.00019831237,0.0001428166,0.00031393685,0.000346627,0.0004217598,0.001999952],"category_scores_gemma":[0.00020616481,0.00017843745,0.00025367536,0.00012484012,0.00018338895,0.0002399688,0.00021248966,0.0004996181,0.0006300981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003159014,0.00003451132,0.00006855395,0.00003773782,0.0000094952575,0.00007032008,0.000014055381,0.00015262203,0.99726117,0.00013577721,0.000059975486,0.001839914],"study_design_scores_gemma":[0.000038604783,0.00043683208,0.00044527647,0.000002418332,0.00001478471,0.00014219857,0.0000042075303,0.0003838329,0.9975567,0.000014218561,0.00095764146,0.000003251712],"about_ca_topic_score_codex":0.0003209922,"about_ca_topic_score_gemma":0.0003240689,"teacher_disagreement_score":0.001999952,"about_ca_system_score_codex":0.00031880153,"about_ca_system_score_gemma":0.00014109793,"threshold_uncertainty_score":0.006690502},"labels":[],"label_agreement":null},{"id":"W2030451774","doi":"10.1016/j.bmcl.2012.09.009","title":"Gene-silencing properties of siRNAs that contain internal amide-bond linkages","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Tech University","funders":"","keywords":"Small interfering RNA; Chemistry; Gene silencing; RNA interference; RNA silencing; Trans-acting siRNA; RNA; Amide; Cell biology; Stereochemistry; Gene; Biochemistry; Biology","score_opus":0.021010952305948963,"score_gpt":0.2243285042573508,"score_spread":0.20331755195140183,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030451774","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99437016,0.00051721884,0.0019169779,0.000052860774,0.000021006283,0.000014450146,0.00017884004,0.000043199703,0.0028852501],"genre_scores_gemma":[0.99734974,0.00019074736,0.00073775585,0.000038526276,0.0000061944174,0.000012866677,0.00029556014,0.000016602104,0.001352092],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992037,0.000017695633,0.000008301817,0.000013624336,0.00002234115,0.0000177151],"domain_scores_gemma":[0.99979347,0.00008878888,0.0000387617,0.000018719531,0.000029764158,0.00003052584],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023204897,0.0002137365,0.0001358002,0.00013882226,0.00011962105,0.00019966134,0.00013094948,0.00022407,0.0013518867],"category_scores_gemma":[0.00028780603,0.000104825085,0.00021612635,0.00007260625,0.00019312109,0.00012364428,0.00009364744,0.00027843256,0.00031346758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000050863327,0.000004850749,0.00003618809,0.0000073692404,0.0000018444356,0.000012333273,0.0000046877626,0.00002800832,0.99950755,0.000048705315,0.000009798148,0.0002879354],"study_design_scores_gemma":[0.0000045886363,0.00007000155,0.00043492508,6.09766e-7,0.0000038817034,0.000033185428,0.0000023005416,0.00018316139,0.9990694,0.000010725733,0.00018554431,0.0000016267778],"about_ca_topic_score_codex":0.00030810531,"about_ca_topic_score_gemma":0.00044331542,"teacher_disagreement_score":0.0013518867,"about_ca_system_score_codex":0.00016010371,"about_ca_system_score_gemma":0.0001184561,"threshold_uncertainty_score":0.004522562},"labels":[],"label_agreement":null},{"id":"W2030491250","doi":"10.1016/j.bmcl.2004.11.057","title":"Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"European Commission","keywords":"Malonate; Isozyme; Oxalate; Chemistry; Carbonic anhydrase; Carbonic Anhydrase I; Malate dehydrogenase; Cytosol; Biochemistry; Formate; Stereochemistry; Enzyme; Inorganic chemistry; Catalysis","score_opus":0.00436310202040927,"score_gpt":0.19758362365616353,"score_spread":0.19322052163575426,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030491250","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82684916,0.1076281,0.018674154,0.0017334226,0.0007243934,0.00029629018,0.0011737283,0.00040550047,0.042515237],"genre_scores_gemma":[0.96476793,0.01851422,0.0026535024,0.00024700124,0.00009766206,0.000068510206,0.00063479075,0.00002695578,0.012989392],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998945,0.000016777327,0.0000056389845,0.000017014218,0.000036113343,0.000030000261],"domain_scores_gemma":[0.99995327,0.000015781561,0.000009055572,0.0000031267416,0.0000066196153,0.000012128887],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015268315,0.00035106274,0.00021925948,0.00013850941,0.00015602075,0.00016649332,0.00029558432,0.00024553377,0.0010144975],"category_scores_gemma":[0.0001829497,0.00012286623,0.00017677312,0.000091382826,0.000121663055,0.00013558878,0.000111072324,0.000374749,0.0003519719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011374558,0.00007863965,0.00029301803,0.00022153712,0.00002972062,0.00017766679,0.000023611497,0.0005088873,0.97857726,0.001985613,0.0010819302,0.0158846],"study_design_scores_gemma":[0.000084687104,0.0003986671,0.0008522692,0.000008624601,0.000026136599,0.00025172278,0.0000047558447,0.00078189594,0.98626477,0.0001594714,0.011161426,0.000005694237],"about_ca_topic_score_codex":0.0013006495,"about_ca_topic_score_gemma":0.0024631545,"teacher_disagreement_score":0.0013006495,"about_ca_system_score_codex":0.00031790166,"about_ca_system_score_gemma":0.00017944002,"threshold_uncertainty_score":0.0033938289},"labels":[],"label_agreement":null},{"id":"W2030609112","doi":"10.1016/j.bmcl.2011.04.082","title":"Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Linker; NS5B; Carboxamide; Stereochemistry; Indole test; ADME; Biochemistry; In vitro; Genotype; Hepacivirus","score_opus":0.026912227957280488,"score_gpt":0.24796662233523842,"score_spread":0.22105439437795793,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030609112","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99359643,0.0016117812,0.0017222558,0.000060749313,0.000022606575,0.00004914218,0.00037268194,0.00010259129,0.0024616465],"genre_scores_gemma":[0.9952101,0.00095482444,0.0013578889,0.00003795055,0.0000072444736,0.000024329196,0.00044427012,0.00001265026,0.0019507632],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993813,0.000009686681,0.000004479176,0.000008584101,0.000012641117,0.00002644528],"domain_scores_gemma":[0.99996674,0.000008396372,0.000007344941,0.000004469268,0.0000045725888,0.000008497129],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015659575,0.0002934352,0.00028992913,0.00013641616,0.0001231542,0.00018117003,0.00026722995,0.000157935,0.0012708294],"category_scores_gemma":[0.00011467972,0.00014160255,0.00018922926,0.00011362788,0.000117981726,0.00013587688,0.000090044894,0.0003073534,0.00023885554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005209666,0.00012878128,0.00015443999,0.000068080575,0.000012501166,0.00008001925,0.00005006388,0.001706667,0.99059033,0.0001857647,0.00029733195,0.0062049646],"study_design_scores_gemma":[0.0001855385,0.0029709812,0.0015464809,0.0000069461616,0.000038451053,0.00016131077,0.000023555125,0.0030415258,0.9897947,0.000050061222,0.0021637748,0.000016811306],"about_ca_topic_score_codex":0.0022258507,"about_ca_topic_score_gemma":0.004789143,"teacher_disagreement_score":0.0022258507,"about_ca_system_score_codex":0.00028853162,"about_ca_system_score_gemma":0.00020931374,"threshold_uncertainty_score":0.0044258237},"labels":[],"label_agreement":null},{"id":"W2030770366","doi":"10.1016/j.bmcl.2008.12.117","title":"Corrigendum to “Deconstructing estradiol: Removal of B-ring generates compounds which are potent and subtype-selective estrogen receptor agonists” [Bioorg. Med. Chem. Lett. 19 (2009) 1250–1253]","year":2009,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University; University of Ottawa","funders":"","keywords":"Chemistry; Estrogen receptor; Ring (chemistry); Estrogen; Stereochemistry; Internal medicine; Organic chemistry; Cancer; Medicine; Breast cancer","score_opus":0.010993799360725226,"score_gpt":0.2219079538865607,"score_spread":0.21091415452583548,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030770366","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00015734434,0.003789965,0.00041822242,0.035822306,0.9478837,0.000052573538,0.0009674965,0.00034534396,0.010563051],"genre_scores_gemma":[0.009596329,0.02606339,0.0033285527,0.10237934,0.19643195,0.00023263451,0.003984947,0.00071185577,0.65727097],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99722666,0.00022915119,0.00042500065,0.00039991387,0.0013472897,0.0003720632],"domain_scores_gemma":[0.9930802,0.0013264101,0.00045086266,0.00046365496,0.0042262287,0.00045268468],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0019839457,0.0031990635,0.0031922616,0.0032943306,0.0035055685,0.002725904,0.004461701,0.0070404788,0.08957453],"category_scores_gemma":[0.015303041,0.0015785776,0.0026016764,0.0026151799,0.0021045634,0.0023063251,0.0019503032,0.0065031233,0.06510776],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00004275694,0.000015840707,0.000042503536,0.00020908148,0.000015002414,0.00031231198,0.0000120249715,0.000066084576,0.0002110719,0.000563382,0.99203205,0.006477917],"study_design_scores_gemma":[0.00004375921,0.000050361454,0.001124977,0.0001671472,0.000054234955,0.00038517293,0.00003397042,0.00019178844,0.001244729,0.00088398234,0.99576867,0.000051368952],"about_ca_topic_score_codex":0.022507956,"about_ca_topic_score_gemma":0.035202917,"teacher_disagreement_score":0.08957453,"about_ca_system_score_codex":0.0052366923,"about_ca_system_score_gemma":0.0037352215,"threshold_uncertainty_score":0.29965663},"labels":[],"label_agreement":null},{"id":"W2030787636","doi":"10.1016/j.bmcl.2014.06.013","title":"Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Diastereomer; Geminal; Stereochemistry; Antimicrobial; Antibacterial activity; Stereoisomerism; Combinatorial chemistry; Chemical synthesis; Yeast; Staphylococcus aureus; Bacteria; Biochemistry; In vitro; Organic chemistry; Catalysis","score_opus":0.028499134212692335,"score_gpt":0.25478870849464286,"score_spread":0.2262895742819505,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030787636","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9966287,0.0001255784,0.0010889921,0.00008742089,0.000031790067,0.000014275846,0.00020226285,0.00004842582,0.001772482],"genre_scores_gemma":[0.9986106,0.00010805537,0.00042403012,0.00003806156,0.0000047701774,0.000005061153,0.00009807096,0.000014729433,0.00069650845],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991167,0.00001535896,0.000007828088,0.000015662381,0.00001408074,0.00003540694],"domain_scores_gemma":[0.999874,0.000024033065,0.000031555097,0.000024291836,0.000019531533,0.000026552347],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010993662,0.00023330374,0.00014480687,0.00012073665,0.00011786783,0.00015946792,0.00027095512,0.00024769225,0.0040752785],"category_scores_gemma":[0.00023325636,0.00010751081,0.00015817508,0.00014863482,0.00025173917,0.00025785787,0.00014781606,0.000431613,0.00061153754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000636366,0.000026477172,0.00022480433,0.000022098087,0.000006924909,0.00007632093,0.000017936223,0.00019460017,0.99616206,0.00045319743,0.000047235695,0.0021319995],"study_design_scores_gemma":[0.000039852075,0.00032354472,0.001381104,0.0000030643876,0.000017675633,0.00007177561,0.000019035391,0.00041428374,0.9965714,0.00010422057,0.001046038,0.00000792849],"about_ca_topic_score_codex":0.0008051236,"about_ca_topic_score_gemma":0.0011499976,"teacher_disagreement_score":0.0040752785,"about_ca_system_score_codex":0.00027416882,"about_ca_system_score_gemma":0.0002809477,"threshold_uncertainty_score":0.013633192},"labels":[],"label_agreement":null},{"id":"W2031470038","doi":"10.1016/j.bmcl.2007.12.027","title":"On the mechanism of demethylation of 5-methylcytosine in DNA","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Demethylation; Demethylase; DNA demethylation; DNA methylation; Chemistry; DNA; Methyltransferase; Methylation; Recombinant DNA; 5-Methylcytosine; Sf9; Biochemistry; Molecular biology; Gene; Gene expression; Histone; Biology","score_opus":0.009018820507876371,"score_gpt":0.23452986274479862,"score_spread":0.22551104223692225,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2031470038","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5518007,0.1985444,0.17286703,0.013743588,0.0048413267,0.00028633143,0.0008234423,0.000449118,0.05664411],"genre_scores_gemma":[0.9102338,0.05830425,0.011780259,0.001065004,0.0007336389,0.00012008771,0.0003852178,0.00004624322,0.017331451],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998073,0.000033921187,0.000011441868,0.00005985536,0.000035262332,0.000052241037],"domain_scores_gemma":[0.9998505,0.00007138994,0.000015886391,0.000019909778,0.000025603062,0.000016702657],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00091322867,0.0005188922,0.00054972933,0.00055528915,0.00082445424,0.0005279314,0.0014357386,0.0011103479,0.0031181655],"category_scores_gemma":[0.0004809771,0.00034683855,0.0005873061,0.00026682465,0.0009575051,0.0020064483,0.0008234406,0.0012701185,0.0009450178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016353256,0.00014129098,0.0018151675,0.0019858505,0.00023686035,0.0029008384,0.00062872184,0.00795178,0.70727986,0.18249851,0.003978297,0.088947445],"study_design_scores_gemma":[0.000082377184,0.0007166702,0.0019501257,0.0001411284,0.0001744677,0.0012024336,0.00025330103,0.010234936,0.89815146,0.03931832,0.047668066,0.000106637555],"about_ca_topic_score_codex":0.0014127472,"about_ca_topic_score_gemma":0.0014324295,"teacher_disagreement_score":0.0031181655,"about_ca_system_score_codex":0.00087835075,"about_ca_system_score_gemma":0.0005421423,"threshold_uncertainty_score":0.01043129},"labels":[],"label_agreement":null},{"id":"W2031498189","doi":"10.1016/j.bmcl.2010.11.084","title":"Azaindoles as potent CRTH2 receptor antagonists","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Stereochemistry; Pharmacokinetics; Antagonist; Structural isomer; Chemical synthesis; Structure–activity relationship; Receptor; Combinatorial chemistry; In vitro; Biochemistry","score_opus":0.003594928298812503,"score_gpt":0.21358436707803544,"score_spread":0.20998943877922294,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2031498189","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.89942706,0.055039965,0.0108193355,0.0014586871,0.00073580275,0.00030575946,0.001591509,0.000747215,0.029874653],"genre_scores_gemma":[0.96427333,0.019730072,0.003003152,0.00060052215,0.00017167289,0.00010670904,0.00084672257,0.000040693136,0.011227243],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999014,0.00002482446,0.0000056872195,0.000014316771,0.000019409663,0.00003425877],"domain_scores_gemma":[0.99996614,0.000008450688,0.000006137749,0.00000362766,0.0000038004318,0.000011910314],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024546587,0.00038371823,0.000514566,0.00026355576,0.0001993853,0.0003635698,0.00039047058,0.00029471904,0.003130492],"category_scores_gemma":[0.00012853132,0.00018169491,0.00014908591,0.0001823054,0.00020999317,0.0003045279,0.00028618702,0.0008239587,0.00080646045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015107777,0.00014491873,0.00029449203,0.0003027838,0.000059632017,0.0003781114,0.00010730457,0.0013451945,0.94711596,0.00434441,0.0030987056,0.04129766],"study_design_scores_gemma":[0.0017287264,0.00849077,0.0058555477,0.000058839145,0.00019706324,0.0019292154,0.00009640011,0.004225252,0.87933177,0.001504613,0.096471235,0.00011048777],"about_ca_topic_score_codex":0.00046630236,"about_ca_topic_score_gemma":0.0017084326,"teacher_disagreement_score":0.003130492,"about_ca_system_score_codex":0.00034724004,"about_ca_system_score_gemma":0.00012016558,"threshold_uncertainty_score":0.010472536},"labels":[],"label_agreement":null},{"id":"W2031793626","doi":"10.1016/j.bmcl.2008.08.032","title":"Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; SH2 domain; Moiety; Catechol; Stereochemistry; Virtual screening; Biochemistry; Combinatorial chemistry; Enzyme; Drug discovery; Protein tyrosine phosphatase","score_opus":0.01073310267643952,"score_gpt":0.23213962451116774,"score_spread":0.22140652183472823,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2031793626","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9796045,0.0025966018,0.0079801455,0.0003055991,0.000061829196,0.00024231084,0.0007527623,0.0002805424,0.008175749],"genre_scores_gemma":[0.9925101,0.0011072797,0.0038381603,0.000067120855,0.000008833111,0.000037270056,0.00055044837,0.000014689013,0.0018661144],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9999156,0.000018295872,0.000003794391,0.000015295684,0.00002337477,0.000023667882],"domain_scores_gemma":[0.9999548,0.000011520339,0.000008338961,0.0000039883985,0.000005788825,0.00001552656],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018511116,0.00044177272,0.0006219338,0.00034148054,0.00028810525,0.00061517744,0.00042813254,0.00027557428,0.0014566684],"category_scores_gemma":[0.00017033271,0.00017100578,0.00040522288,0.0002607984,0.00018192704,0.00017432279,0.0003077551,0.00042842462,0.00024952975],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0023450225,0.0013097452,0.002916473,0.0003886723,0.000271541,0.0010584071,0.000084708765,0.033482954,0.88914007,0.0024621817,0.00170189,0.064838335],"study_design_scores_gemma":[0.0017112062,0.006003062,0.0041901874,0.000038989627,0.0006193826,0.0013056415,0.00008142543,0.0962831,0.87131274,0.0006569427,0.017713996,0.0000832554],"about_ca_topic_score_codex":0.0010799072,"about_ca_topic_score_gemma":0.0020516035,"teacher_disagreement_score":0.0014566684,"about_ca_system_score_codex":0.00043280039,"about_ca_system_score_gemma":0.00035399414,"threshold_uncertainty_score":0.004873097},"labels":[],"label_agreement":null},{"id":"W2031929606","doi":"10.1016/j.bmcl.2009.11.017","title":"Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Dalhousie University; Universities Space Research Association","keywords":"Chemistry; Purine; Purine metabolism; Xanthine; Biochemistry; ATP synthase; Uric acid; Escherichia coli; Purine analogue; Enzyme; Stereochemistry","score_opus":0.005531447069174287,"score_gpt":0.2259990644870686,"score_spread":0.2204676174178943,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2031929606","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99449134,0.0015717047,0.0020243004,0.00017063192,0.000045306748,0.00003263628,0.00025210646,0.00006842401,0.0013435417],"genre_scores_gemma":[0.9964562,0.0006723933,0.0012400014,0.000037215348,0.000011515756,0.000023716844,0.0003943752,0.000015306292,0.0011492333],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997365,0.000069402966,0.000040116895,0.00002642001,0.00006579217,0.00006176114],"domain_scores_gemma":[0.9998234,0.00007178197,0.000029400719,0.000024283729,0.000018638966,0.000032558466],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002936902,0.00048275533,0.00034405227,0.00023047352,0.00015065429,0.00034319054,0.0003366842,0.00036903706,0.000792028],"category_scores_gemma":[0.00035871746,0.00022059248,0.000272647,0.00026931733,0.0002548103,0.0002435749,0.0002870538,0.00054182514,0.0002588466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080551184,0.00010584851,0.00030349265,0.00007406624,0.00001946476,0.00015201175,0.000028161965,0.00045099726,0.9942942,0.00030408485,0.00009836281,0.0033637688],"study_design_scores_gemma":[0.000022327844,0.00016758553,0.00056047225,0.0000039770007,0.000005489188,0.00006768588,0.0000074225445,0.0010046763,0.9976252,0.000028814,0.00050257426,0.0000037643688],"about_ca_topic_score_codex":0.0013789494,"about_ca_topic_score_gemma":0.0009784213,"teacher_disagreement_score":0.0013789494,"about_ca_system_score_codex":0.00036129545,"about_ca_system_score_gemma":0.0002673469,"threshold_uncertainty_score":0.0027418733},"labels":[],"label_agreement":null},{"id":"W2032275574","doi":"10.1016/j.bmcl.2009.07.107","title":"From natural products to achiral drug prototypes: Potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Thrombin; Discovery and development of direct thrombin inhibitors; Serine protease; Enzyme; Enzyme inhibitor; Selectivity; Stereochemistry; Serine; Inhibitory postsynaptic potential; Protease; Trypsin; Serine Proteinase Inhibitors; Biochemistry; Catalysis","score_opus":0.007473434962767482,"score_gpt":0.21958989465934128,"score_spread":0.2121164596965738,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2032275574","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.80344623,0.03145064,0.08721668,0.0025843314,0.0008202754,0.00067849335,0.0015951028,0.0013128249,0.07089537],"genre_scores_gemma":[0.9409228,0.014059332,0.029977076,0.0006026021,0.00009142855,0.00015796607,0.0007802275,0.00010762739,0.01330093],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990284,0.00002481898,0.000007327925,0.000018253028,0.000027794322,0.000019041881],"domain_scores_gemma":[0.999908,0.000022529304,0.000014129625,0.00001358343,0.0000152027715,0.000026423053],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025768904,0.00038387795,0.00020486522,0.00019007575,0.00016049638,0.0007731863,0.00044839273,0.00031468866,0.0028436128],"category_scores_gemma":[0.0004026723,0.00024253142,0.000193129,0.0001537932,0.00042850696,0.000732568,0.0005507533,0.00084688363,0.0012577946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007361855,0.00024341154,0.0003185658,0.0006809821,0.000032346783,0.0013519492,0.0002612294,0.0030916291,0.85976493,0.025339907,0.003142348,0.10503651],"study_design_scores_gemma":[0.000167694,0.0033171226,0.0005635447,0.00008293107,0.000041819996,0.0017596988,0.00010960283,0.002805669,0.9013948,0.0094410945,0.08027087,0.00004507246],"about_ca_topic_score_codex":0.00013502302,"about_ca_topic_score_gemma":0.0002768351,"teacher_disagreement_score":0.0028436128,"about_ca_system_score_codex":0.00032708657,"about_ca_system_score_gemma":0.00022952814,"threshold_uncertainty_score":0.009512842},"labels":[],"label_agreement":null},{"id":"W2032279197","doi":"10.1016/j.bmcl.2008.04.055","title":"Stereospecific deuteration of α-furanosyl azomycin nucleosides: A model reaction for tritium radiolabeling","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Ministry of Health and Medical Education","keywords":"Chemistry; Stereospecificity; Ribose; Moiety; Yield (engineering); Stereochemistry; Tritium; Arabinose; Deuterium; Chemical synthesis; Organic chemistry; In vitro; Biochemistry; Xylose; Catalysis","score_opus":0.059064100732867886,"score_gpt":0.25086866325248425,"score_spread":0.19180456251961636,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2032279197","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96816564,0.001488638,0.018837841,0.00020835672,0.00006352667,0.00010955487,0.0003790398,0.0001249434,0.010622566],"genre_scores_gemma":[0.9919155,0.0007594986,0.004611832,0.000032634336,0.000007975955,0.000026089298,0.000207603,0.000030865434,0.0024080018],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985695,0.000043653396,0.0000074172945,0.000031643307,0.000018407576,0.000042018513],"domain_scores_gemma":[0.99987125,0.000044370787,0.000024460725,0.000028881104,0.000012504809,0.00001853135],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000418752,0.00033794687,0.00031496,0.00021074175,0.0002768581,0.00030376852,0.00040564244,0.00042790014,0.0012249933],"category_scores_gemma":[0.0002748595,0.0001392457,0.00015446247,0.00021270312,0.0003618149,0.00036587086,0.00021947888,0.00046718217,0.0002856704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00045150227,0.000040490777,0.0002455664,0.000113692266,0.00001418619,0.0003079276,0.00015816402,0.0013889037,0.9884504,0.003617808,0.00023560887,0.004975677],"study_design_scores_gemma":[0.000026908794,0.00015497307,0.00017452496,0.0000039811935,0.000010322571,0.00012800253,0.000014412473,0.0005932445,0.9966949,0.00013205533,0.0020601687,0.0000065421677],"about_ca_topic_score_codex":0.0013965147,"about_ca_topic_score_gemma":0.0017000441,"teacher_disagreement_score":0.0013965147,"about_ca_system_score_codex":0.0008260671,"about_ca_system_score_gemma":0.00040807427,"threshold_uncertainty_score":0.005993545},"labels":[],"label_agreement":null},{"id":"W2032394645","doi":"10.1016/j.bmcl.2012.11.042","title":"Unprecedented spirocyclization of 3-methyleneindoline-2-thiones during hydrolysis of the phytoalexin cyclobrassinin","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Phytoalexin; Chemistry; Alternaria brassicicola; Indole test; Hydrolysis; Cycloaddition; Stereochemistry; Biochemistry; Arabidopsis; Catalysis; Gene","score_opus":0.013844179466624595,"score_gpt":0.22846140291965114,"score_spread":0.21461722345302656,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2032394645","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98636127,0.00080400443,0.0041996473,0.0001318269,0.000066669854,0.00006733035,0.00014366311,0.00013839366,0.008087273],"genre_scores_gemma":[0.9973354,0.0002771356,0.0006602433,0.000036863377,0.000007893713,0.000014900574,0.0000877168,0.000015260593,0.0015645818],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998723,0.000020914811,0.0000069921416,0.000018515999,0.000019719373,0.00006156756],"domain_scores_gemma":[0.9999448,0.000010393629,0.000016340593,0.000011252692,0.0000054450124,0.000011771304],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017909643,0.000291705,0.00015757623,0.00013681778,0.00015951111,0.00023388883,0.00026640878,0.00028846724,0.0015891569],"category_scores_gemma":[0.00017745387,0.00011340597,0.00023287727,0.000105076986,0.00020604474,0.00026577123,0.00024470946,0.0003903874,0.00051408046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00041513503,0.00011333023,0.00040585734,0.00010128973,0.000016036225,0.0006525786,0.00025070857,0.0007746625,0.9849872,0.0020161194,0.00030532232,0.009961777],"study_design_scores_gemma":[0.000059326354,0.0009876087,0.0023455676,0.000014650886,0.000013719005,0.0005840734,0.00008233005,0.0012964212,0.9883434,0.00024668803,0.0060038934,0.00002237475],"about_ca_topic_score_codex":0.0003743903,"about_ca_topic_score_gemma":0.0009741005,"teacher_disagreement_score":0.0015891569,"about_ca_system_score_codex":0.00019390562,"about_ca_system_score_gemma":0.0002872416,"threshold_uncertainty_score":0.0053162575},"labels":[],"label_agreement":null},{"id":"W2032686566","doi":"10.1016/j.bmcl.2012.03.057","title":"Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Plant Toxicity and Pharmacological Properties","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Farnesoid X receptor; Chemistry; Agonist; Chenodeoxycholic acid; Ligand (biochemistry); Endogeny; Potency; Nuclear receptor; Partial agonist; Natural product; Receptor; Stereochemistry; Pharmacology; Biochemistry; In vitro; Bile acid","score_opus":0.021955920453160412,"score_gpt":0.24991871588516604,"score_spread":0.22796279543200562,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2032686566","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96550256,0.021177495,0.004734381,0.0002616705,0.000052915813,0.000067526846,0.00040826577,0.000103506754,0.0076915664],"genre_scores_gemma":[0.98729044,0.0054650633,0.0018326953,0.00015586133,0.00001763376,0.000026691318,0.00039644362,0.000006745752,0.004808439],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999877,0.0000022701133,7.425049e-7,0.0000025260254,0.000002452437,0.0000042581114],"domain_scores_gemma":[0.9999869,0.0000023928044,0.0000043233317,0.0000010950962,0.000001381177,0.0000038703233],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000038855294,0.00018114207,0.00014243144,0.00014104802,0.00009966842,0.0001286559,0.00013420997,0.00015671868,0.0011522049],"category_scores_gemma":[0.00003944044,0.000057887213,0.0000941554,0.00006687175,0.00011204311,0.0001422036,0.00012327438,0.00023459615,0.00022961485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020797188,0.00001718157,0.00018817834,0.00009660077,0.0000056309104,0.00011420181,0.000011957607,0.00003100109,0.9894671,0.00015120655,0.00007626075,0.009632782],"study_design_scores_gemma":[0.00015113858,0.002203694,0.024096914,0.000050986728,0.0000924133,0.0017195456,0.0000610393,0.00050994195,0.931543,0.00021157732,0.039335173,0.000024552915],"about_ca_topic_score_codex":0.000518645,"about_ca_topic_score_gemma":0.0012856206,"teacher_disagreement_score":0.0011522049,"about_ca_system_score_codex":0.000108580454,"about_ca_system_score_gemma":0.000080439626,"threshold_uncertainty_score":0.0038545728},"labels":[],"label_agreement":null},{"id":"W2033320661","doi":"10.1016/j.bmcl.2014.08.017","title":"The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Nav1.7","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Sodium channel; Selectivity; Pharmacology; Sodium channel blocker; Drug discovery; Structure–activity relationship; In vitro; Sodium; Biochemistry; Medicine","score_opus":0.004933786468808732,"score_gpt":0.1947297934795727,"score_spread":0.18979600701076396,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2033320661","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9144223,0.04254177,0.018479822,0.0017319327,0.00049762096,0.000319014,0.0012496165,0.00057307584,0.02018495],"genre_scores_gemma":[0.95751274,0.022331407,0.006864918,0.00061404007,0.00010995852,0.00009013614,0.0010991895,0.000040467068,0.011337231],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998715,0.000021244943,0.0000072163257,0.000016943519,0.000040297713,0.000042741398],"domain_scores_gemma":[0.99992526,0.000011239323,0.000017260349,0.0000050461426,0.000019684885,0.000021523238],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039284368,0.00048848,0.00039941122,0.00027676256,0.00015610391,0.00044082833,0.00045208028,0.00032382493,0.0014800895],"category_scores_gemma":[0.00028574615,0.00017944342,0.00029050047,0.00016893924,0.00031126267,0.00034638995,0.00039083738,0.0006451599,0.00058945146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006124995,0.0003258563,0.00072446465,0.0004455506,0.000091580696,0.00049974455,0.00015330839,0.0027373517,0.8962799,0.008237139,0.00401828,0.085874245],"study_design_scores_gemma":[0.0005895833,0.003987896,0.0035628602,0.000062660365,0.00014439475,0.0012932007,0.00007444254,0.0075030453,0.901556,0.0012656796,0.079888225,0.000071928494],"about_ca_topic_score_codex":0.00072758814,"about_ca_topic_score_gemma":0.0023860275,"teacher_disagreement_score":0.0014800895,"about_ca_system_score_codex":0.00049201207,"about_ca_system_score_gemma":0.0004373617,"threshold_uncertainty_score":0.0049514174},"labels":[],"label_agreement":null},{"id":"W2033422748","doi":"10.1016/j.bmcl.2013.07.031","title":"Chemical variation from the neoantimycin depsipeptide assembly line","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Depsipeptide; Nonribosomal peptide; Chemistry; Polyketide; Natural product; Stereochemistry; Absolute configuration; Polyketide synthase; Biosynthesis; Cyclic peptide; Combinatorial chemistry; Chemical synthesis; Peptide; Computational biology; Biochemistry; Enzyme; In vitro; Biology","score_opus":0.009834739197854783,"score_gpt":0.20997051323841043,"score_spread":0.20013577404055566,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2033422748","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98034084,0.00023701055,0.009826124,0.00018801361,0.00006480113,0.000051478844,0.00055174256,0.0002653562,0.008474587],"genre_scores_gemma":[0.9909184,0.00018176304,0.005774474,0.000106932086,0.0000101483565,0.000032929594,0.00046034952,0.00011160781,0.0024032844],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999014,0.000019998824,0.000009218847,0.000022083019,0.00002797362,0.000019267121],"domain_scores_gemma":[0.99984336,0.000034540477,0.00004075479,0.00003402905,0.000021634016,0.000025643982],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120133605,0.0002718574,0.00011835336,0.00015834198,0.00020124523,0.0003009088,0.00028856215,0.00023659848,0.0018741194],"category_scores_gemma":[0.00023340808,0.00017982865,0.00013057678,0.00016937198,0.00017684561,0.0001736663,0.00020101623,0.0007245496,0.00061095384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000078752106,0.000012268839,0.00005517901,0.000013302327,0.0000026364003,0.00006485588,0.000012070176,0.00032336157,0.9977709,0.00037934814,0.0000739723,0.0012134794],"study_design_scores_gemma":[0.000011749906,0.00012561808,0.00026268617,0.0000017418286,0.0000048935976,0.000063027175,0.0000071837103,0.0010273765,0.9963192,0.00007095323,0.0021009604,0.0000047340086],"about_ca_topic_score_codex":0.0003763843,"about_ca_topic_score_gemma":0.0005779243,"teacher_disagreement_score":0.0018741194,"about_ca_system_score_codex":0.00033661726,"about_ca_system_score_gemma":0.00015760961,"threshold_uncertainty_score":0.006269574},"labels":[],"label_agreement":null},{"id":"W2033686481","doi":"10.1016/j.bmcl.2005.12.010","title":"Aryl O- and S-galactosides and lactosides as specific inhibitors of human galectins-1 and -3: Role of electrostatic potential at O-3","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Wilfrid Laurier University; Université Laval; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Galactosides; Galectin; Monosaccharide; Aryl; Stereochemistry; Thio-; Combinatorial chemistry; Glycoside; Biochemistry; Organic chemistry; Alkyl","score_opus":0.002395144523448765,"score_gpt":0.18171397202629075,"score_spread":0.17931882750284198,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2033686481","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99079823,0.0027834617,0.0020802699,0.00006968529,0.000029788413,0.000030835225,0.00009847841,0.0000517473,0.004057633],"genre_scores_gemma":[0.99583614,0.0013036018,0.0009451923,0.000049153048,0.000007376393,0.00001638842,0.000088044704,0.000011230485,0.0017428505],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999926,0.000023429022,0.0000039949723,0.0000073412725,0.000014072242,0.000025092944],"domain_scores_gemma":[0.9999589,0.000013042049,0.000008277793,0.0000041944136,0.0000043414393,0.000011335161],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154277,0.000248892,0.00017941347,0.00011598237,0.00010365921,0.00019404027,0.0002223994,0.00016826212,0.0011088412],"category_scores_gemma":[0.00014473729,0.00011443294,0.00016822007,0.00015767092,0.00014836069,0.0001490086,0.00020437318,0.00030717673,0.00016306197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010154572,0.00008499376,0.00021968868,0.000053752072,0.000016898184,0.00009316631,0.00003967896,0.0007815687,0.98943967,0.0006510135,0.00016887335,0.007435251],"study_design_scores_gemma":[0.0000929015,0.0009100594,0.0010100523,0.000006257622,0.000021880858,0.00016048236,0.00001759503,0.0018365637,0.9931819,0.00009311447,0.002661503,0.000007627492],"about_ca_topic_score_codex":0.00077875773,"about_ca_topic_score_gemma":0.0014811378,"teacher_disagreement_score":0.0011088412,"about_ca_system_score_codex":0.00022198012,"about_ca_system_score_gemma":0.00017952728,"threshold_uncertainty_score":0.003709495},"labels":[],"label_agreement":null},{"id":"W2033891675","doi":"10.1016/j.bmcl.2010.01.157","title":"Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Chemistry; Pharmacophore; CYP3A4; Stereochemistry; Cytochrome P450; Aldol reaction; Chemical synthesis; Enzyme; Biochemistry; Combinatorial chemistry; In vitro","score_opus":0.0038839839638420692,"score_gpt":0.21084669814956705,"score_spread":0.20696271418572498,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2033891675","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9921038,0.001996967,0.0014500354,0.00012886788,0.000044162844,0.00005178279,0.00041599316,0.00009247246,0.003716029],"genre_scores_gemma":[0.99536186,0.0011454171,0.0010645555,0.000048569676,0.00001747593,0.000019263054,0.00045876173,0.000013484226,0.0018706663],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990463,0.000022385264,0.000009936358,0.000012963211,0.000024390914,0.000025728916],"domain_scores_gemma":[0.9999473,0.00001052171,0.000013734732,0.0000095093255,0.000007971554,0.000010992984],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103904444,0.00025949624,0.00023233147,0.00010185404,0.00010969587,0.0001235084,0.00015087107,0.0001367025,0.0009113003],"category_scores_gemma":[0.00013532747,0.00012194518,0.00013582144,0.00013013986,0.00010488447,0.00010820897,0.00010497503,0.00041064122,0.0003004811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046020758,0.000063377556,0.0001833212,0.000034905876,0.000012577181,0.00008593452,0.000017438257,0.0002573026,0.99395895,0.000103547536,0.00018103069,0.004641436],"study_design_scores_gemma":[0.000121142846,0.0019247017,0.0021149672,0.0000026619155,0.000020640695,0.0006670979,0.000011834047,0.0006929706,0.99141145,0.000031642983,0.0029964265,0.0000044270773],"about_ca_topic_score_codex":0.00046449166,"about_ca_topic_score_gemma":0.001648903,"teacher_disagreement_score":0.0009113003,"about_ca_system_score_codex":0.00018506862,"about_ca_system_score_gemma":0.00016190896,"threshold_uncertainty_score":0.0030485988},"labels":[],"label_agreement":null},{"id":"W2034024979","doi":"10.1016/s0960-894x(03)00311-1","title":"Inhibition of mandelate racemase by α-fluorobenzylphosphonates","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo; Dalhousie University","funders":"","keywords":"Chemistry; Mandelic acid; Stereochemistry; Enantiomer; Enzyme; Substrate (aquarium); Alpha (finance); Stereoisomerism; Biochemistry; Catalysis; Organic chemistry","score_opus":0.003457697713450199,"score_gpt":0.19479048878799926,"score_spread":0.19133279107454906,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034024979","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98429227,0.004887364,0.0030159103,0.00019979807,0.00007922794,0.000062017214,0.00027897145,0.00020581191,0.0069785514],"genre_scores_gemma":[0.9947218,0.0014983407,0.00096477167,0.000041820094,0.000013820927,0.000024413854,0.00022962106,0.000013373581,0.0024920234],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983716,0.000035339403,0.000012952475,0.000022690067,0.000027275639,0.00006446863],"domain_scores_gemma":[0.99992085,0.000027968617,0.0000173912,0.000008863517,0.000009536683,0.000015396587],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971884,0.00042173066,0.0002782402,0.00022092651,0.0002126932,0.00022031796,0.00029236876,0.0002950488,0.0019097341],"category_scores_gemma":[0.00021703746,0.00016948508,0.00024638692,0.00014771729,0.00018194108,0.0001816982,0.0002171337,0.000408672,0.00043524892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007107182,0.000041151186,0.00009554798,0.00005826383,0.000011425005,0.00009211159,0.000020766685,0.00019550335,0.99478877,0.00032830136,0.00010037608,0.003557162],"study_design_scores_gemma":[0.00001960567,0.00018335148,0.00024726815,0.0000019343051,0.000004670391,0.00006316402,0.000004688031,0.00020885248,0.9979607,0.00001962155,0.0012840956,0.0000020812554],"about_ca_topic_score_codex":0.0017400939,"about_ca_topic_score_gemma":0.0018478552,"teacher_disagreement_score":0.0019097341,"about_ca_system_score_codex":0.0003979679,"about_ca_system_score_gemma":0.00024445623,"threshold_uncertainty_score":0.0063886642},"labels":[],"label_agreement":null},{"id":"W2034218987","doi":"10.1016/j.bmcl.2007.06.023","title":"The identification of potent, selective, and bioavailable cathepsin S inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Cathepsin; Moiety; Bioavailability; Substituent; Biochemistry; Structure–activity relationship; Sulfonyl; Chemical synthesis; Stereochemistry; Enzyme; In vivo; Enzyme inhibitor; Cathepsin D; Prodrug; In vitro; Pharmacology","score_opus":0.00402523032373261,"score_gpt":0.20938295778961338,"score_spread":0.20535772746588077,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034218987","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8763776,0.07113701,0.036182802,0.0015979345,0.0003444569,0.00032058186,0.0012808817,0.00038045814,0.012378314],"genre_scores_gemma":[0.94773614,0.026734244,0.01110148,0.0004380567,0.00011793504,0.00014189613,0.001592303,0.000032403324,0.012105538],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987006,0.000017448794,0.000010771985,0.00002384558,0.000043745193,0.000034183056],"domain_scores_gemma":[0.99992144,0.000016677819,0.000016606842,0.000007986217,0.00001397655,0.000023386525],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035509554,0.0005483075,0.0004758502,0.0003045221,0.00014045615,0.0006989627,0.00033728627,0.00042791077,0.0012507525],"category_scores_gemma":[0.00027696186,0.00021478163,0.0002246099,0.00018428364,0.00026439285,0.0004415624,0.000322171,0.0009887777,0.0004750186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00081525237,0.00032362476,0.0005258532,0.0003114472,0.000035134814,0.00032901188,0.00006018972,0.001080786,0.9409042,0.0035480321,0.0016739239,0.050392598],"study_design_scores_gemma":[0.0003267118,0.0016786277,0.0012491853,0.000023406661,0.00007146615,0.001412925,0.000030465626,0.0016926907,0.96132475,0.0006464947,0.03152107,0.00002219173],"about_ca_topic_score_codex":0.00020212964,"about_ca_topic_score_gemma":0.00065157027,"teacher_disagreement_score":0.0012507525,"about_ca_system_score_codex":0.0004595895,"about_ca_system_score_gemma":0.00035936967,"threshold_uncertainty_score":0.004184127},"labels":[],"label_agreement":null},{"id":"W2034297428","doi":"10.1016/j.bmcl.2014.05.067","title":"Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Cancer Research UK; Cancer Research Institute","keywords":"Chemistry; Phenocopy; Apoptosis; Gene knockdown; Phenotype; Phosphatase; Oncogene; Cell culture; Cell; Drug discovery; Cancer research; Cell biology; Biochemistry; Gene; Cell cycle; Enzyme; Biology; Genetics","score_opus":0.007333115352925546,"score_gpt":0.2174247817595602,"score_spread":0.21009166640663465,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034297428","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9889642,0.0010684907,0.0062749833,0.000211666,0.000059217396,0.000055392004,0.0010052361,0.00035124586,0.0020095618],"genre_scores_gemma":[0.992564,0.00056671497,0.0031960136,0.00006990815,0.000008015884,0.0000637378,0.00091113924,0.00006007964,0.0025603978],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997249,0.00003379431,0.00003506393,0.000053007047,0.000096813885,0.000056416775],"domain_scores_gemma":[0.9998104,0.00006262115,0.00003931462,0.00003315457,0.00002093884,0.00003354075],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018439646,0.00036005743,0.0003878063,0.0003205876,0.0002017732,0.00029323692,0.00035235545,0.0003745354,0.001121498],"category_scores_gemma":[0.00019495138,0.00022374337,0.0002506583,0.00026891503,0.0002663458,0.00016120452,0.0001900975,0.0007161553,0.00037111432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005816325,0.000023138258,0.0001073113,0.000015004578,0.0000053443814,0.00006012825,0.000012164422,0.000055424232,0.9989159,0.00006915269,0.000079137855,0.00059911114],"study_design_scores_gemma":[0.000013880536,0.000080866026,0.00081877527,0.0000010412915,0.0000073507663,0.00019447932,0.000008389917,0.0004612701,0.9976267,0.000016011863,0.0007695387,0.0000015759421],"about_ca_topic_score_codex":0.0014483153,"about_ca_topic_score_gemma":0.002689777,"teacher_disagreement_score":0.0014483153,"about_ca_system_score_codex":0.00043507759,"about_ca_system_score_gemma":0.00024582612,"threshold_uncertainty_score":0.0037517548},"labels":[],"label_agreement":null},{"id":"W2034350901","doi":"10.1016/j.bmcl.2006.06.090","title":"Exploring alternative Zn-binding groups in the design of HDAC inhibitors: Squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Consiglio Nazionale delle Ricerche","keywords":"Squaric acid; Chemistry; Oxazoline; Stereochemistry; Hydroxamic acid; Hydroxymethyl; Enzyme inhibitor; Cytotoxicity; Chemical synthesis; Structure–activity relationship; Cell culture; Biochemistry; In vitro; Organic chemistry","score_opus":0.037498026638675734,"score_gpt":0.25060796025748855,"score_spread":0.2131099336188128,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034350901","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9584976,0.00809382,0.025532577,0.00049930025,0.00013233119,0.0003351172,0.0002958053,0.00032687656,0.006286528],"genre_scores_gemma":[0.97991097,0.0035622432,0.014218621,0.0001429334,0.000022625014,0.00009517823,0.00025652774,0.00002329093,0.0017675583],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998901,0.00002709389,0.000013357687,0.00002362973,0.000022282575,0.000023491653],"domain_scores_gemma":[0.99991095,0.000013731535,0.000021656535,0.000007851163,0.000021361118,0.000024394838],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375479,0.00041431218,0.00048512878,0.0002258085,0.0002288719,0.00036258504,0.0009673841,0.00036914667,0.0011852628],"category_scores_gemma":[0.000266262,0.00021112004,0.00025320056,0.00020772856,0.00032049682,0.00042258058,0.00030166458,0.0004771697,0.0003523056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018534866,0.00018980408,0.0003861353,0.00031481413,0.00003745367,0.00031893083,0.000086996726,0.003181967,0.9669002,0.0022286142,0.00026957566,0.024231924],"study_design_scores_gemma":[0.0008944669,0.003276483,0.00061097107,0.000033508204,0.00011018038,0.00039460763,0.000054921096,0.004241736,0.975132,0.000449507,0.014767034,0.000034605317],"about_ca_topic_score_codex":0.0012790845,"about_ca_topic_score_gemma":0.0028885633,"teacher_disagreement_score":0.0012790845,"about_ca_system_score_codex":0.00041937915,"about_ca_system_score_gemma":0.0003850378,"threshold_uncertainty_score":0.0039651394},"labels":[],"label_agreement":null},{"id":"W2034736243","doi":"10.1016/j.bmcl.2009.11.122","title":"Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H3 receptor antagonists","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Histamine H3 receptor; Benzimidazole; Indole test; Potency; Amine gas treating; Stereochemistry; Histamine; Antagonist; Biogenic amine; Chemical synthesis; Pharmacology; Structure–activity relationship; Receptor; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry; Neurotransmitter","score_opus":0.006143600006962321,"score_gpt":0.20621293044258068,"score_spread":0.20006933043561836,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034736243","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.870709,0.08476083,0.0124729,0.0012431912,0.0009491384,0.0002326931,0.0005572204,0.00063996523,0.02843505],"genre_scores_gemma":[0.9525068,0.030911451,0.0044094566,0.0005185845,0.00023142654,0.000119120225,0.00046510602,0.000057063557,0.010781014],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984777,0.000031858457,0.000008075615,0.000017355931,0.000032185795,0.000062656036],"domain_scores_gemma":[0.999948,0.000009112033,0.000012559121,0.0000043984614,0.000010399791,0.00001561685],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031656,0.00035444953,0.0004716098,0.00028211903,0.00024365344,0.000320605,0.0008041717,0.0003943765,0.0018725609],"category_scores_gemma":[0.00020536121,0.00023354987,0.00020728655,0.00022046402,0.00022409542,0.0003787296,0.0001930953,0.00068092707,0.000661762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016526033,0.00028021928,0.00020740766,0.0004160377,0.000028357364,0.0003658436,0.00012306745,0.0008379908,0.9366321,0.0031902571,0.0024533204,0.053812813],"study_design_scores_gemma":[0.0012413786,0.007958112,0.007237263,0.00010179794,0.00019020481,0.001586833,0.00007935262,0.005808575,0.8832239,0.00093791203,0.091518536,0.00011607276],"about_ca_topic_score_codex":0.0009673988,"about_ca_topic_score_gemma":0.002354412,"teacher_disagreement_score":0.0018725609,"about_ca_system_score_codex":0.00043502948,"about_ca_system_score_gemma":0.00022614072,"threshold_uncertainty_score":0.0062643886},"labels":[],"label_agreement":null},{"id":"W2034745446","doi":"10.1016/j.bmcl.2004.06.077","title":"A novel cyclic enkephalin analogue with potent opioid antagonist activity","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Propanoic acid; Stereochemistry; Antagonist; Agonist; Enkephalin; Opioid peptide; Opioid; Cyclic peptide; Chemical synthesis; Opioid receptor; Opioid antagonist; Peptide; Receptor; Biochemistry; In vitro; (+)-Naloxone","score_opus":0.020448131745488273,"score_gpt":0.23080483453452263,"score_spread":0.21035670278903437,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034745446","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9651901,0.006633274,0.0078666685,0.000642998,0.00032776326,0.00024360213,0.0009306535,0.00019918969,0.01796559],"genre_scores_gemma":[0.9850735,0.0028241808,0.004365619,0.0002879332,0.00005934045,0.000054762266,0.0006540526,0.000021016029,0.0066596307],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999387,0.0000071811587,0.000004976193,0.000013431508,0.000010650102,0.000025016134],"domain_scores_gemma":[0.9999627,0.000004231183,0.000006446334,0.0000032327084,0.0000052188975,0.000018221144],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009187423,0.00027169572,0.0003456321,0.00014953424,0.00019135227,0.00022055756,0.00060412724,0.0003920188,0.0019105942],"category_scores_gemma":[0.00009917958,0.000112935246,0.0001327158,0.00013612743,0.00016863072,0.0002746078,0.00020679086,0.00045477913,0.00048478163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009873065,0.00021894787,0.00015162908,0.00029526645,0.000023413735,0.001301659,0.00007452914,0.0009307587,0.9651249,0.0012492203,0.00091329304,0.028729018],"study_design_scores_gemma":[0.00063621224,0.008680082,0.0030951719,0.000042170635,0.00010881651,0.003693326,0.00005445926,0.0024083601,0.9385475,0.00046212735,0.04219055,0.000081261525],"about_ca_topic_score_codex":0.0004919734,"about_ca_topic_score_gemma":0.0006943392,"teacher_disagreement_score":0.0019105942,"about_ca_system_score_codex":0.00019621705,"about_ca_system_score_gemma":0.00020842016,"threshold_uncertainty_score":0.006391585},"labels":[],"label_agreement":null},{"id":"W2034945606","doi":"10.1016/j.bmcl.2010.09.134","title":"N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Centre National de la Recherche Scientifique","keywords":"Chemistry; Neuroprotection; Oxidative stress; Peroxisome proliferator-activated receptor; Peroxisome; Pharmacology; Receptor; Stereochemistry; Biochemistry","score_opus":0.006616803368440186,"score_gpt":0.19843816001064382,"score_spread":0.19182135664220362,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034945606","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92941946,0.025696315,0.019877413,0.000849577,0.00046811838,0.00010368342,0.0006534104,0.0006200201,0.022311946],"genre_scores_gemma":[0.9830815,0.005320555,0.004441314,0.00023816142,0.000064928645,0.000059755836,0.0002509457,0.000020143058,0.00652268],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994636,0.00001579449,0.0000042533,0.000009802263,0.000011270709,0.000012466262],"domain_scores_gemma":[0.9999584,0.000005820776,0.000011994733,0.000004050108,0.000007832069,0.000011822744],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015778147,0.00020787596,0.0002064337,0.00012808976,0.00012297746,0.000084611915,0.0003224153,0.0002587405,0.0023621202],"category_scores_gemma":[0.000097418895,0.00008325577,0.000099005345,0.00009078032,0.00012973655,0.00020525864,0.0001152412,0.00026931838,0.0008283952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00059253647,0.00007405029,0.00013361697,0.00019307861,0.000010794498,0.00017006611,0.00002570103,0.00021662087,0.9821004,0.00091888045,0.00058088737,0.014983384],"study_design_scores_gemma":[0.00019629592,0.0018498227,0.0022408122,0.000025669842,0.00003974564,0.0009898636,0.00003834002,0.0009451444,0.96813446,0.0002745574,0.0252461,0.000019269512],"about_ca_topic_score_codex":0.00031886296,"about_ca_topic_score_gemma":0.00060313224,"teacher_disagreement_score":0.0023621202,"about_ca_system_score_codex":0.00013254619,"about_ca_system_score_gemma":0.00010988464,"threshold_uncertainty_score":0.007902145},"labels":[],"label_agreement":null},{"id":"W2034946866","doi":"10.1016/j.bmcl.2008.10.026","title":"Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Reboxetine; Atomoxetine; Reuptake inhibitor; Norepinephrine; Selectivity; Norepinephrine transporter; Reuptake; Potency; Chemical synthesis; Stereochemistry; Pharmacology; Dopamine; Serotonin; Biochemistry; In vitro; Internal medicine; Receptor; Attention deficit hyperactivity disorder","score_opus":0.018927830497467865,"score_gpt":0.2521734727483981,"score_spread":0.2332456422509302,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2034946866","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9212579,0.035252135,0.014591268,0.00074914336,0.00039273777,0.00052575173,0.002211663,0.00042199678,0.02459743],"genre_scores_gemma":[0.958995,0.016957093,0.007607276,0.00028952342,0.00009663227,0.00020901035,0.0019249567,0.00004599206,0.013874631],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999254,0.000010825352,0.0000075159064,0.000011928437,0.000014702511,0.000029674211],"domain_scores_gemma":[0.9999546,0.0000074097393,0.000012692423,0.000004121259,0.00000768736,0.000013573962],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013475626,0.0004599013,0.0003989833,0.0002623911,0.00020093001,0.0002985633,0.0006375554,0.00029164826,0.0026983914],"category_scores_gemma":[0.00011967558,0.0002463122,0.00022478083,0.00017085666,0.0001576795,0.00029602766,0.00020722943,0.00045513123,0.0008914095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006789582,0.00028127612,0.00021990077,0.0005640304,0.00003998192,0.00068052637,0.00012932034,0.0011024075,0.9549273,0.0021453397,0.0011468151,0.03808414],"study_design_scores_gemma":[0.0006439744,0.004677494,0.0034542326,0.000076337485,0.00016791596,0.0015480559,0.00006263077,0.0025238264,0.94181204,0.00041264112,0.04454538,0.00007528878],"about_ca_topic_score_codex":0.00056040037,"about_ca_topic_score_gemma":0.0022220532,"teacher_disagreement_score":0.0026983914,"about_ca_system_score_codex":0.00032357496,"about_ca_system_score_gemma":0.00036379395,"threshold_uncertainty_score":0.009027004},"labels":[],"label_agreement":null},{"id":"W2035008017","doi":"10.1016/j.bmcl.2013.05.069","title":"Phosphinic acid-based inhibitors of tubulin polyglutamylases","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Tubulin; Chemistry; Microtubule; Enzyme; Biochemistry; Function (biology); Stereochemistry; Cell biology; Biology","score_opus":0.007351663025557828,"score_gpt":0.2077396171863896,"score_spread":0.20038795416083177,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035008017","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9412918,0.023483485,0.007967845,0.00065804843,0.00033445697,0.00017469369,0.00081588264,0.00072866696,0.024545139],"genre_scores_gemma":[0.97986174,0.011747674,0.0013577881,0.00016934008,0.000036735066,0.000042713273,0.00046736412,0.000021742566,0.006294881],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999207,0.000011840893,0.0000087084245,0.000011246178,0.00001857792,0.000028867744],"domain_scores_gemma":[0.9999721,0.0000055066416,0.000007071693,0.0000030144427,0.000004552506,0.000007862605],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016064536,0.0004445215,0.00028813796,0.00029549134,0.00020282676,0.0003379506,0.0003672615,0.0002647662,0.0015204048],"category_scores_gemma":[0.00012914103,0.00017227579,0.00019507634,0.00022862632,0.00013181755,0.00027470442,0.00022204935,0.0005779598,0.0004183456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015627274,0.0003868809,0.0002652244,0.00035210894,0.000090545465,0.0006227825,0.00006520569,0.002389669,0.9402006,0.002644788,0.0019985843,0.049420822],"study_design_scores_gemma":[0.00053616153,0.00213846,0.0014001124,0.00002182776,0.00008954025,0.0006059244,0.000025596308,0.0027201641,0.9713732,0.0003984479,0.02066377,0.000026872583],"about_ca_topic_score_codex":0.0007787848,"about_ca_topic_score_gemma":0.0020262366,"teacher_disagreement_score":0.0015204048,"about_ca_system_score_codex":0.0003844876,"about_ca_system_score_gemma":0.0001974166,"threshold_uncertainty_score":0.005086243},"labels":[],"label_agreement":null},{"id":"W2035176763","doi":"10.1016/j.bmcl.2009.03.105","title":"Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Bronchoconstriction; In vivo; Pharmacology; Lipophilicity; Stereochemistry; Ovalbumin; Pharmacokinetics; Alkyl; Chemical synthesis; Enzyme inhibitor; Structure–activity relationship; In vitro; Biochemistry; Asthma; Organic chemistry; Immunology; Antigen","score_opus":0.005360390474512403,"score_gpt":0.21465343917153226,"score_spread":0.20929304869701987,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035176763","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9453771,0.018552661,0.012352939,0.00060874916,0.00048393116,0.00017351798,0.00068772025,0.0006194605,0.021143924],"genre_scores_gemma":[0.9785382,0.006951551,0.0043479297,0.0002927611,0.00007187102,0.00007166761,0.0005435604,0.000052329684,0.009130046],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986565,0.00003208683,0.000010376505,0.000017356342,0.000028495537,0.000046059187],"domain_scores_gemma":[0.99995136,0.00001018192,0.000010608726,0.0000060239186,0.0000082247725,0.000013591535],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037743492,0.0003634544,0.00050587783,0.00021436099,0.00016771958,0.00023822488,0.00082833203,0.0003776687,0.0024503397],"category_scores_gemma":[0.00016401005,0.00019325684,0.00018573827,0.00020349196,0.00022937938,0.0003276349,0.0003940473,0.00075554603,0.00071858976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014176439,0.00034667994,0.00026461543,0.00042903912,0.00004830374,0.0004937956,0.0001862056,0.0030314345,0.9461223,0.0041227667,0.0021752324,0.04136209],"study_design_scores_gemma":[0.0016415967,0.010661027,0.0038600457,0.0001063394,0.0001661059,0.001326909,0.00012121454,0.0064602583,0.89147663,0.0012482079,0.082809106,0.00012259357],"about_ca_topic_score_codex":0.0007322713,"about_ca_topic_score_gemma":0.0020518426,"teacher_disagreement_score":0.0024503397,"about_ca_system_score_codex":0.00035352554,"about_ca_system_score_gemma":0.00022939667,"threshold_uncertainty_score":0.008197248},"labels":[],"label_agreement":null},{"id":"W2035207400","doi":"10.1016/s0960-894x(01)00589-3","title":"Novel 5-Vinyl Pyrimidine Nucleosides with Potent anti-Hepatitis B Virus Activity","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Hydroxymethyl; Pyrimidine; Stereochemistry; Chemical synthesis; Hepatitis B virus; In vitro; Nucleoside; Cell culture; Virus; Biochemistry; Virology","score_opus":0.023725855345641155,"score_gpt":0.265024788617677,"score_spread":0.24129893327203583,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035207400","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9594296,0.016517645,0.008010258,0.00030864467,0.00028898608,0.00020748394,0.00066783855,0.00027161403,0.014297891],"genre_scores_gemma":[0.98124814,0.0055242092,0.0068314592,0.00022582643,0.00006233481,0.00009236697,0.0006951686,0.000026891654,0.005293582],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999014,0.000021790782,0.000010711074,0.000016981525,0.000019661733,0.000029397153],"domain_scores_gemma":[0.99992967,0.000011010238,0.000016314156,0.0000076177303,0.000008403784,0.000026869577],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019413205,0.00043320656,0.0004446444,0.00031789043,0.00023975952,0.00039074093,0.00045160844,0.0004586079,0.0019787345],"category_scores_gemma":[0.00017428224,0.00021560605,0.00020363423,0.00022560295,0.00019201884,0.00023654684,0.00027829324,0.0004497774,0.0005315826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009786652,0.0002308299,0.00038217154,0.00035338115,0.00005186424,0.000752478,0.00010997108,0.0015973172,0.9471797,0.0016338675,0.0007321403,0.045997612],"study_design_scores_gemma":[0.0005098399,0.006857836,0.0031468328,0.00005218261,0.00011096898,0.0026101272,0.000047620906,0.0023710923,0.94245553,0.00042286562,0.041368008,0.00004708824],"about_ca_topic_score_codex":0.00050533446,"about_ca_topic_score_gemma":0.0012408881,"teacher_disagreement_score":0.0019787345,"about_ca_system_score_codex":0.00028985285,"about_ca_system_score_gemma":0.00024919832,"threshold_uncertainty_score":0.006619513},"labels":[],"label_agreement":null},{"id":"W2035995875","doi":"10.1016/j.bmcl.2011.10.039","title":"Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Chemistry; Aldol reaction; Aromatase; Pharmacophore; Stereochemistry; Cytochrome P450; Aldehyde; Selectivity; CYP3A4; Chemical synthesis; Adduct; Structure–activity relationship; Combinatorial chemistry; Enzyme; In vitro; Biochemistry; Organic chemistry","score_opus":0.023692338217478393,"score_gpt":0.23663283118258363,"score_spread":0.21294049296510523,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035995875","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93627745,0.018220508,0.029678859,0.0012548475,0.00032350566,0.00054671534,0.0017619396,0.0009971149,0.0109391],"genre_scores_gemma":[0.9692387,0.008638086,0.009503608,0.00041428325,0.000078025616,0.00014257363,0.0019129801,0.000035921556,0.010035719],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990165,0.000011367345,0.000005605567,0.000019249585,0.000027436074,0.000034729048],"domain_scores_gemma":[0.9999436,0.0000056465483,0.000012899451,0.0000045195306,0.000011807966,0.000021562688],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025403698,0.0004933879,0.00039541966,0.00028914874,0.00017289651,0.00043640987,0.00048361666,0.00047711036,0.0015799017],"category_scores_gemma":[0.00017724282,0.00017056952,0.00027968222,0.0002594668,0.00021263742,0.00027236177,0.0002687748,0.0006874986,0.00053752196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035263016,0.00025491486,0.00059998856,0.000171383,0.00004444135,0.0006546237,0.00009390529,0.0007028572,0.9612571,0.0015041886,0.0023190985,0.032044932],"study_design_scores_gemma":[0.00051096827,0.0036895669,0.0048535434,0.000022634014,0.00015401129,0.003348059,0.000051793224,0.0028957906,0.92739576,0.00032624436,0.056705307,0.000046305944],"about_ca_topic_score_codex":0.0009177257,"about_ca_topic_score_gemma":0.0041164397,"teacher_disagreement_score":0.0015799017,"about_ca_system_score_codex":0.00046295606,"about_ca_system_score_gemma":0.0003170874,"threshold_uncertainty_score":0.0052853227},"labels":[],"label_agreement":null},{"id":"W2036009746","doi":"10.1016/j.bmcl.2011.06.106","title":"Synthesis and in vitro evaluation of derivatives of the β1-adrenergic receptor antagonist HX-CH 44","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Antagonist; In vitro; Quinazolinone; Isopropyl; Receptor; Adrenergic receptor; Stereochemistry; Adrenergic; Receptor antagonist; Adrenergic antagonist; Chemical synthesis; Medicinal chemistry; Biochemistry","score_opus":0.02200311012076418,"score_gpt":0.23176206868836302,"score_spread":0.20975895856759885,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036009746","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97322285,0.006575374,0.008166186,0.00021778923,0.000082705825,0.00028532787,0.0013339694,0.00014544047,0.009970249],"genre_scores_gemma":[0.9776748,0.005403992,0.0060634175,0.00010188064,0.000032895456,0.00009421286,0.0019153106,0.00003804276,0.008675424],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998921,0.000025538136,0.000009660469,0.0000138077285,0.000024975972,0.000033863784],"domain_scores_gemma":[0.999943,0.000010532748,0.000010992717,0.0000067432343,0.0000100541765,0.000018740016],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016348512,0.00030679948,0.00031419194,0.00017433494,0.00020608855,0.00018348217,0.00032992178,0.0002238123,0.0029808942],"category_scores_gemma":[0.00014922103,0.00018232419,0.00024458164,0.00019184446,0.0001116748,0.0001863869,0.0001772888,0.00042822846,0.0008538609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002983388,0.00017237141,0.00008252649,0.000097979726,0.000017114153,0.0001675442,0.000040071838,0.000656743,0.9925608,0.0002482011,0.00017467492,0.0054836003],"study_design_scores_gemma":[0.00008142008,0.0021195142,0.00067683787,0.0000074132026,0.00004586734,0.0002106592,0.000021371097,0.00044354532,0.99029166,0.00004539661,0.006044946,0.000011297706],"about_ca_topic_score_codex":0.0009310969,"about_ca_topic_score_gemma":0.0013720035,"teacher_disagreement_score":0.0029808942,"about_ca_system_score_codex":0.00018988663,"about_ca_system_score_gemma":0.00032492555,"threshold_uncertainty_score":0.009972036},"labels":[],"label_agreement":null},{"id":"W2036032002","doi":"10.1016/j.bmcl.2011.06.110","title":"Synthesis and preliminary evaluation of a modified estradiol-core bearing a fused γ-lactone as non-estrogenic inhibitor of 17β-hydroxysteroid dehydrogenase type 1","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Wilfrid Laurier University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Hydroxysteroid dehydrogenase; Steroid; Benzamide; Stereochemistry; Lactone; Dehydrogenase; Enzyme inhibitor; Enzyme; Potency; Estrogen; 11β-hydroxysteroid dehydrogenase type 1; IC50; Biochemistry; Pharmacology; Endocrinology; In vitro; Hormone","score_opus":0.024986936920973223,"score_gpt":0.24455672375261164,"score_spread":0.2195697868316384,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036032002","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98779684,0.0024087008,0.006227808,0.00006549004,0.000041821233,0.00012191334,0.00032563315,0.00007351204,0.0029383483],"genre_scores_gemma":[0.99046963,0.001202572,0.0048026447,0.000044646764,0.000008866034,0.00002932444,0.0004152527,0.000012735326,0.003014446],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995995,0.0000047610097,0.0000030962408,0.000009172537,0.000009833829,0.000013201704],"domain_scores_gemma":[0.99996793,0.000003353421,0.000007693228,0.0000045120437,0.000006279832,0.000010140728],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100310775,0.00023271989,0.00022016697,0.00008626579,0.00010122612,0.00013297674,0.0002826799,0.00017602985,0.00069395953],"category_scores_gemma":[0.00008036985,0.00008670024,0.00016129969,0.00009800983,0.00009771381,0.00014162362,0.0001440946,0.00021548787,0.00025276808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023782034,0.000073579,0.00010394031,0.000080252,0.000010939077,0.00012972456,0.000023280523,0.0006083174,0.9931316,0.00022365838,0.000088726134,0.0052882014],"study_design_scores_gemma":[0.000027604001,0.00089206337,0.00057935127,0.0000028133884,0.000017130662,0.00013908395,0.0000070204933,0.0006656608,0.99395615,0.000027900027,0.0036784003,0.0000068004542],"about_ca_topic_score_codex":0.0005027357,"about_ca_topic_score_gemma":0.00088521134,"teacher_disagreement_score":0.00069395953,"about_ca_system_score_codex":0.00016983468,"about_ca_system_score_gemma":0.00019466293,"threshold_uncertainty_score":0.0023214817},"labels":[],"label_agreement":null},{"id":"W2036246935","doi":"10.1016/s0960-894x(01)00776-4","title":"4-Anilino-3-cyanobenzo[g]quinolines as Kinase Inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Kinase; Bicyclic molecule; Proto-oncogene tyrosine-protein kinase Src; Enzyme inhibitor; Protein kinase A; Stereochemistry; Biochemistry; Enzyme","score_opus":0.019465900608455624,"score_gpt":0.21036498144783006,"score_spread":0.19089908083937443,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036246935","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.80997324,0.11342147,0.015509815,0.0010766651,0.0006913339,0.00035263758,0.00088654895,0.0010834023,0.057004873],"genre_scores_gemma":[0.9654339,0.020890625,0.0029699318,0.00019727086,0.000087264256,0.00007436795,0.0003359068,0.000039829265,0.009970926],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987566,0.00003297453,0.0000059351355,0.00001712046,0.00002160076,0.00004673361],"domain_scores_gemma":[0.9999516,0.000009960372,0.000009310688,0.0000041524017,0.000008834986,0.000016145832],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025707457,0.00033587965,0.00036311813,0.00037402392,0.00021939415,0.000346248,0.0006350792,0.00034378585,0.0021773828],"category_scores_gemma":[0.00013462192,0.0001618991,0.00015482448,0.0002375184,0.00020589706,0.0003277361,0.0002813425,0.00048921176,0.00067175843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014421246,0.0002567486,0.0004120502,0.00058860984,0.00003988798,0.0005372526,0.00013880803,0.0025771551,0.93557316,0.0073635303,0.0024500445,0.048620652],"study_design_scores_gemma":[0.0008515516,0.0052558775,0.006431961,0.00012312779,0.00011743883,0.0018362958,0.00012523541,0.0059562065,0.8389264,0.0015851068,0.13870235,0.000088489025],"about_ca_topic_score_codex":0.0011883355,"about_ca_topic_score_gemma":0.002775403,"teacher_disagreement_score":0.0021773828,"about_ca_system_score_codex":0.00048149182,"about_ca_system_score_gemma":0.00019599829,"threshold_uncertainty_score":0.007284105},"labels":[],"label_agreement":null},{"id":"W2036773204","doi":"10.1016/j.bmcl.2013.12.069","title":"Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Ticlopidine; Chemistry; Thienopyridine; Isoquinoline; Stereochemistry; Pharmacology; Clopidogrel; Biochemistry; Medicine","score_opus":0.012576792709501577,"score_gpt":0.225812822641107,"score_spread":0.21323602993160543,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036773204","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9692723,0.0043281903,0.015607718,0.0003694313,0.00012853941,0.00035315333,0.0006239043,0.00027204034,0.009044757],"genre_scores_gemma":[0.99047273,0.0016043192,0.0056188446,0.0001601863,0.000011304416,0.000060041344,0.0004159825,0.00001857888,0.0016378989],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999409,0.000011335876,0.000005461597,0.000012811671,0.00001068012,0.000018798079],"domain_scores_gemma":[0.9999181,0.000011185842,0.00002846528,0.0000071590753,0.000012219925,0.000022794973],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013335196,0.00038291307,0.00026054564,0.00015410307,0.00015402478,0.00036303987,0.0004362801,0.00033817024,0.0014784569],"category_scores_gemma":[0.00021770524,0.00014590974,0.00016196918,0.00015736767,0.00018592503,0.00029153677,0.0001434537,0.0005170733,0.00037216925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015869075,0.00021915536,0.00031786266,0.00020653995,0.000038453403,0.00038372248,0.00005593572,0.0025235936,0.9749087,0.0014805287,0.0006164297,0.017662095],"study_design_scores_gemma":[0.0008763968,0.0039221174,0.0011654994,0.000028027862,0.00013240795,0.0009527756,0.0000608621,0.0069201435,0.9677461,0.0003905763,0.017769428,0.00003560824],"about_ca_topic_score_codex":0.00062905916,"about_ca_topic_score_gemma":0.0013760003,"teacher_disagreement_score":0.0014784569,"about_ca_system_score_codex":0.00034996952,"about_ca_system_score_gemma":0.00028047693,"threshold_uncertainty_score":0.004945934},"labels":[],"label_agreement":null},{"id":"W2036890299","doi":"10.1016/j.bmcl.2007.03.014","title":"6-Hydroxy to 6‴-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3′)-IIIa kinase","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Paromomycin; Ring (chemistry); Aminoglycoside; Stereochemistry; Kinase; Molecular model; Antibiotics; Biochemistry; Organic chemistry","score_opus":0.013927090857830008,"score_gpt":0.253063461526736,"score_spread":0.23913637066890597,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036890299","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98566586,0.0025256947,0.005747029,0.00020767715,0.00008699182,0.000048601672,0.00022554367,0.00017581834,0.00531675],"genre_scores_gemma":[0.9906742,0.0010737866,0.004206024,0.00010997579,0.000021792375,0.000036713504,0.00016672828,0.000035995537,0.0036746925],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998834,0.000032890555,0.000006801527,0.000024412877,0.000023497212,0.000028944709],"domain_scores_gemma":[0.99989164,0.000027071463,0.000028565251,0.00001579468,0.000010892495,0.000026080867],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019736335,0.00024129375,0.00023911803,0.00012821842,0.00015549942,0.000257442,0.0002459032,0.0003358233,0.0015262236],"category_scores_gemma":[0.00019602878,0.00017503113,0.00016421896,0.000107975815,0.00022609998,0.0002851689,0.00020846329,0.00059143995,0.0005322455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016572344,0.000016233023,0.000057841204,0.000028841265,0.0000040204927,0.00006904804,0.000027977781,0.0001573661,0.9970847,0.00024308018,0.00005489514,0.002090262],"study_design_scores_gemma":[0.000014289003,0.00019920719,0.0004245164,0.000002918638,0.0000061251326,0.00011354857,0.000009658092,0.00031175473,0.99664766,0.000045232886,0.0022201445,0.0000049359905],"about_ca_topic_score_codex":0.00030200672,"about_ca_topic_score_gemma":0.00048821745,"teacher_disagreement_score":0.0015262236,"about_ca_system_score_codex":0.00035301666,"about_ca_system_score_gemma":0.00013290423,"threshold_uncertainty_score":0.0051057935},"labels":[],"label_agreement":null},{"id":"W2037434478","doi":"10.1016/j.bmcl.2008.10.009","title":"Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Stereochemistry; Celecoxib; Arachidonate 5-lipoxygenase; Enzyme inhibitor; Moiety; Lipoxygenase; Cyclooxygenase; Enzyme; Chemical synthesis; Hydroxamic acid; Biochemistry; Arachidonic acid; In vitro","score_opus":0.024150664318877583,"score_gpt":0.24903146986469196,"score_spread":0.22488080554581438,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2037434478","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9596946,0.0080211405,0.0144272065,0.00049532455,0.0002906709,0.00081851677,0.0017514919,0.00026893025,0.01423209],"genre_scores_gemma":[0.98536915,0.0035152612,0.006534963,0.0001369237,0.0000511872,0.00013739095,0.0009970845,0.000018197235,0.0032398237],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999397,0.000007893017,0.000005778891,0.0000093801655,0.0000128971005,0.00002444519],"domain_scores_gemma":[0.99994886,0.000005058519,0.0000139170115,0.000005069724,0.000006536466,0.00002054188],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012478145,0.00039901887,0.00046829903,0.00022445702,0.00020676128,0.00020981947,0.00037475346,0.0002796113,0.0028408167],"category_scores_gemma":[0.0001484848,0.00020656797,0.00023561923,0.00024396935,0.00014711931,0.0002764822,0.0001761284,0.00044569932,0.0004967023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017798806,0.00055781775,0.0002959779,0.00040600824,0.00004941671,0.00096623256,0.0000819731,0.0025294889,0.9549562,0.001836261,0.00073978247,0.03580112],"study_design_scores_gemma":[0.0018642843,0.0065703564,0.0028323298,0.000037185415,0.00018951825,0.0013606129,0.000053426316,0.0038420279,0.95665663,0.000436445,0.02610452,0.00005267362],"about_ca_topic_score_codex":0.00040990024,"about_ca_topic_score_gemma":0.0007828373,"teacher_disagreement_score":0.0028408167,"about_ca_system_score_codex":0.00022108202,"about_ca_system_score_gemma":0.0003676626,"threshold_uncertainty_score":0.009503484},"labels":[],"label_agreement":null},{"id":"W2037510626","doi":"10.1016/j.bmcl.2013.04.082","title":"Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University; Mount Saint Vincent University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; U.S. Public Health Service; Dalhousie Medical Research Foundation","keywords":"Phenothiazine; Chemistry; Neurotransmitter receptor; Neurotransmitter; Pharmacology; Cholinesterase; Cholinergic; Receptor; Dopaminergic; Dopamine; Neuroscience; Biochemistry; Medicine; Biology","score_opus":0.007970212199005797,"score_gpt":0.20902427436664256,"score_spread":0.20105406216763677,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2037510626","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9739526,0.0072509544,0.008803691,0.00044808284,0.00007683846,0.00009440014,0.0006017114,0.0003156057,0.008456061],"genre_scores_gemma":[0.9903537,0.0031531441,0.002211018,0.00011993854,0.000022796883,0.000030780706,0.00051524915,0.000026891385,0.0035664868],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997763,0.000054546217,0.000015683443,0.00003956445,0.000050982013,0.00006286307],"domain_scores_gemma":[0.9998704,0.000051508927,0.000020017878,0.000010752293,0.00002872314,0.000018607801],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003783696,0.0004582196,0.00033289866,0.00020110693,0.00017125478,0.00031704962,0.00042582853,0.000308108,0.0020967317],"category_scores_gemma":[0.0003789629,0.00027973557,0.00013912677,0.00019288699,0.00017357226,0.00027507002,0.00022510128,0.0003912991,0.00056050904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003393897,0.000013844023,0.00020342691,0.000060244467,0.000010615522,0.000053257612,0.000021606544,0.00019111886,0.99497104,0.0003173654,0.00020009495,0.0036181153],"study_design_scores_gemma":[0.00003257728,0.0002169398,0.00054841035,0.0000036641022,0.000017364247,0.00023697552,0.000008302063,0.00066535943,0.9964174,0.000035169192,0.0018139946,0.000003880389],"about_ca_topic_score_codex":0.0013550713,"about_ca_topic_score_gemma":0.0021972863,"teacher_disagreement_score":0.0020967317,"about_ca_system_score_codex":0.0005058113,"about_ca_system_score_gemma":0.00035014423,"threshold_uncertainty_score":0.0070142746},"labels":[],"label_agreement":null},{"id":"W2038074857","doi":"10.1016/j.bmcl.2015.03.006","title":"Synthesis and biological evaluation of nonionic substrate mimics of UDP-Galp as candidate inhibitors of UDP galactopyranose mutase (UGM)","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Council of Scientific and Industrial Research, India; Canadian Bureau for International Education","keywords":"Chemistry; Mutase; Moiety; Stereochemistry; Uridine diphosphate; Pyrimidine; Enzyme; Biochemistry; Substrate (aquarium); Pyrophosphate","score_opus":0.037296825565265125,"score_gpt":0.25704289098099486,"score_spread":0.21974606541572975,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2038074857","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98192775,0.004001571,0.00814974,0.00013183296,0.000052467596,0.00027458594,0.00059683085,0.000109140885,0.0047560274],"genre_scores_gemma":[0.9896416,0.0018952974,0.0050986,0.000042770003,0.000012173046,0.00007394674,0.00060972077,0.000014814038,0.0026111875],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998908,0.000032800333,0.000009513107,0.000016132784,0.000029183599,0.000021520073],"domain_scores_gemma":[0.9999306,0.000010328052,0.00001550779,0.000010891381,0.000013148118,0.000019517409],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002391762,0.0003691002,0.000270547,0.00019034234,0.00014449982,0.00031571792,0.00037571497,0.00032586523,0.0009084157],"category_scores_gemma":[0.00027254436,0.00014834882,0.00022378284,0.00021734249,0.0001341098,0.00019759267,0.00019034924,0.0003486227,0.00031081252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004409411,0.00018037451,0.00017977378,0.00011495213,0.000016825383,0.00027295935,0.000031017913,0.001768548,0.9889159,0.0004723548,0.00015213687,0.007454174],"study_design_scores_gemma":[0.00003623863,0.0010565134,0.00027408605,0.0000039622896,0.00001785364,0.00017016295,0.0000086574,0.001219166,0.9942629,0.000033279906,0.002911996,0.0000050951094],"about_ca_topic_score_codex":0.000413067,"about_ca_topic_score_gemma":0.0004003005,"teacher_disagreement_score":0.0009084157,"about_ca_system_score_codex":0.000312415,"about_ca_system_score_gemma":0.00022772978,"threshold_uncertainty_score":0.0030389428},"labels":[],"label_agreement":null},{"id":"W2038290499","doi":"10.1016/j.bmcl.2005.01.030","title":"Synthesis and fluorescence studies of thiazole orange tethered onto oligonucleotide: development of a self-contained DNA biosensor on a fiber optic surface","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oligonucleotide; Chemistry; DNA; Covalent bond; Biosensor; Fluorescence; Ethylene glycol; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.013630342205536232,"score_gpt":0.25937052416116496,"score_spread":0.24574018195562872,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2038290499","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99230886,0.0003233104,0.006610075,0.000038991,0.000008799717,0.000015013486,0.00006853662,0.00004005693,0.0005865069],"genre_scores_gemma":[0.98946303,0.00033750496,0.007822292,0.000016930813,0.0000056658137,0.000014258344,0.00011824579,0.000013025277,0.002209195],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999248,0.000008635946,0.00000454515,0.000022594148,0.000025715992,0.00001374349],"domain_scores_gemma":[0.99989057,0.000033628025,0.000025833713,0.000009811217,0.000021876875,0.000018201265],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015740459,0.00015035752,0.00014465189,0.00008389165,0.00012258407,0.000101648926,0.00023902071,0.00029858976,0.0006193323],"category_scores_gemma":[0.00022355125,0.00016273564,0.00012703189,0.00010404721,0.00015690723,0.00016722089,0.00009331503,0.00020484804,0.00018021779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000012271176,0.0000040076534,0.000028963537,0.000008791074,7.448521e-7,0.000015278601,0.0000124147,0.000021972208,0.99967456,0.000019203066,0.0000035250234,0.00019824212],"study_design_scores_gemma":[0.0000025150903,0.00007218062,0.0007637297,6.9851393e-7,0.0000033456831,0.00005359903,0.0000066882944,0.00039851686,0.99843913,0.000006314295,0.0002514251,0.000001950035],"about_ca_topic_score_codex":0.0014918908,"about_ca_topic_score_gemma":0.001629647,"teacher_disagreement_score":0.0014918908,"about_ca_system_score_codex":0.00020410154,"about_ca_system_score_gemma":0.00016972443,"threshold_uncertainty_score":0.0029664636},"labels":[],"label_agreement":null},{"id":"W2038296305","doi":"10.1016/j.bmcl.2013.12.036","title":"Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Amide; Moiety; Stereochemistry; Potency; Combinatorial chemistry; In vitro; Chemical synthesis; Drug discovery; Biochemistry","score_opus":0.025239966659840418,"score_gpt":0.2824585877782823,"score_spread":0.2572186211184419,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2038296305","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97597575,0.009457501,0.00767014,0.00028958815,0.00011121505,0.00038692812,0.00072619604,0.00010818715,0.00527454],"genre_scores_gemma":[0.9855036,0.0063457238,0.0050695008,0.00013193545,0.000027375916,0.00008481565,0.0007147202,0.00002091176,0.0021014418],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998565,0.000030095774,0.000015876065,0.000022710637,0.00002988681,0.000044890243],"domain_scores_gemma":[0.999858,0.00002544637,0.000032952637,0.000015955076,0.000036030768,0.000031676886],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00052552426,0.0004919303,0.0004287296,0.00035711378,0.00023008403,0.00028223448,0.00042266198,0.0002970542,0.0017602235],"category_scores_gemma":[0.00035262632,0.0001828557,0.00031161393,0.00029847902,0.00029187746,0.0002852793,0.00029065393,0.00059879065,0.00033601918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022051511,0.0004550359,0.00074410724,0.00036091087,0.00007318481,0.0006576497,0.00017035108,0.0021171954,0.96275276,0.0011984232,0.00043243004,0.028832704],"study_design_scores_gemma":[0.0009128006,0.0077358787,0.0020064318,0.000049867576,0.00021846438,0.00062604056,0.000089298606,0.0013506932,0.9748731,0.00024742252,0.01185606,0.000033885783],"about_ca_topic_score_codex":0.0005991683,"about_ca_topic_score_gemma":0.0014078934,"teacher_disagreement_score":0.0017602235,"about_ca_system_score_codex":0.0003612476,"about_ca_system_score_gemma":0.0005124256,"threshold_uncertainty_score":0.0058885217},"labels":[],"label_agreement":null},{"id":"W2038595841","doi":"10.1016/j.bmcl.2015.02.032","title":"Tandem DNAzymes for mRNA cleavage: Choice of enzyme, metal ions and the antisense effect","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Deoxyribozyme; Chemistry; Tandem; Cleavage (geology); Enzyme; Messenger RNA; Metal ions in aqueous solution; Stereochemistry; Ion; Biophysics; Biochemistry; DNA; Gene; Organic chemistry","score_opus":0.012992334554483757,"score_gpt":0.27306012402243823,"score_spread":0.2600677894679545,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2038595841","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9349763,0.0032537957,0.058384515,0.00035115329,0.00010063042,0.00009109053,0.00016536684,0.0002986342,0.002378464],"genre_scores_gemma":[0.96206033,0.0012109816,0.033224173,0.00012387072,0.000028442673,0.00006999998,0.00016226554,0.00007545005,0.003044621],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999584,0.00006575554,0.000043876636,0.00014781686,0.000100371806,0.00005818983],"domain_scores_gemma":[0.9995757,0.00016868874,0.00009172795,0.000043766067,0.000061952924,0.000058108544],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007045134,0.0004644361,0.00049193844,0.00016851097,0.00015500838,0.00055560836,0.00039559556,0.0007064477,0.0008539651],"category_scores_gemma":[0.0009049325,0.0003446177,0.0003115652,0.0002119288,0.00035363325,0.0004931812,0.00032052494,0.00082300726,0.00051036273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000073565345,0.000009905802,0.00004399189,0.000017478218,0.0000028197896,0.000017218079,0.000008752408,0.000060801107,0.99831957,0.00017164375,0.000014205801,0.00125997],"study_design_scores_gemma":[0.0000074567783,0.000089416295,0.000072004266,0.0000014468078,0.0000064235423,0.00008185948,0.0000035418734,0.00034150938,0.99896383,0.000044480432,0.00038412478,0.000003870323],"about_ca_topic_score_codex":0.00023039641,"about_ca_topic_score_gemma":0.0005796338,"teacher_disagreement_score":0.0008539651,"about_ca_system_score_codex":0.00036127653,"about_ca_system_score_gemma":0.0002734037,"threshold_uncertainty_score":0.0037258863},"labels":[],"label_agreement":null},{"id":"W2038828342","doi":"10.1016/j.bmcl.2007.01.021","title":"Design and synthesis of β-methoxyacrylate analogues via click chemistry and biological evaluations","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Plant Biotechnology Institute","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; Natural Sciences and Engineering Research Council of Canada","keywords":"Click chemistry; Chemistry; Antifungal; Triazole; Alkyne; Combinatorial chemistry; Azide; Biological activity; Chemical synthesis; Stereochemistry; Organic chemistry; In vitro; Biochemistry; Catalysis; Microbiology","score_opus":0.03027408890982039,"score_gpt":0.28542944388036934,"score_spread":0.255155354970549,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2038828342","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9757421,0.0017095131,0.016106285,0.00015999959,0.00011642095,0.00035496565,0.00038232,0.00014858124,0.005279761],"genre_scores_gemma":[0.9848483,0.0012758885,0.008933786,0.0000775543,0.00002441085,0.00013374825,0.0003803259,0.00002651239,0.004299571],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987817,0.000024889263,0.000014877983,0.000020210373,0.000030294925,0.000031486506],"domain_scores_gemma":[0.9998287,0.000036278925,0.00004658067,0.0000201831,0.000030862408,0.000037367703],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004105367,0.00033426168,0.00025518617,0.00017034555,0.00013672074,0.0002124907,0.00030841067,0.00029226675,0.0022478846],"category_scores_gemma":[0.0003810552,0.00016711297,0.00029904587,0.00014036818,0.00016838312,0.00036157249,0.00016057001,0.0005019662,0.0004463281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039444026,0.0001557253,0.0001593682,0.00009448469,0.0000096641925,0.00018033174,0.000032328127,0.0011254891,0.9905804,0.00068364665,0.00012108043,0.006463076],"study_design_scores_gemma":[0.00006605402,0.0012293659,0.00035965184,0.000004801178,0.000016705993,0.00018712065,0.00000881157,0.0010984547,0.993782,0.000059729777,0.0031794193,0.000007900072],"about_ca_topic_score_codex":0.00027121668,"about_ca_topic_score_gemma":0.00032785392,"teacher_disagreement_score":0.0022478846,"about_ca_system_score_codex":0.00016792904,"about_ca_system_score_gemma":0.00019485474,"threshold_uncertainty_score":0.007519901},"labels":[],"label_agreement":null},{"id":"W2039335822","doi":"10.1016/j.bmcl.2008.05.028","title":"Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"University of Toronto","keywords":"Chemistry; Cell cycle progression; Aryl; Chromosomal translocation; Cell cycle; Stereochemistry; Cell; Cell biology; Biochemistry; Organic chemistry; Gene","score_opus":0.007356388165082904,"score_gpt":0.24464654850571507,"score_spread":0.23729016034063216,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2039335822","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9926001,0.0022031823,0.0012909173,0.000075856005,0.000047348396,0.000024936866,0.00013765477,0.000070430724,0.0035496757],"genre_scores_gemma":[0.9953271,0.001348549,0.00065849134,0.000054399366,0.000011311552,0.000017244027,0.0001412022,0.000011548014,0.0024300937],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999093,0.000013669945,0.000008779547,0.000010784916,0.00001527767,0.000042174917],"domain_scores_gemma":[0.9999205,0.0000250152,0.000018439143,0.000012499939,0.0000098728315,0.000013657367],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014245372,0.00023069054,0.00017135493,0.00018150358,0.00015234735,0.00011289488,0.00021104036,0.00020719269,0.0019817378],"category_scores_gemma":[0.0001452606,0.000120451456,0.0001571528,0.00018364882,0.00019373118,0.00016296032,0.00014690959,0.00035162276,0.0002241311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038685434,0.00002859429,0.000097464224,0.000048701702,0.000006247518,0.00009408346,0.000021972395,0.000099464654,0.99739766,0.0002270918,0.00007656769,0.0015152519],"study_design_scores_gemma":[0.00001971633,0.0004107424,0.0010791229,0.000003912254,0.000010599961,0.00007629817,0.000011631559,0.00013869279,0.996995,0.00002021527,0.0012306799,0.000003474849],"about_ca_topic_score_codex":0.0011246107,"about_ca_topic_score_gemma":0.002402852,"teacher_disagreement_score":0.0019817378,"about_ca_system_score_codex":0.00021396914,"about_ca_system_score_gemma":0.00028895665,"threshold_uncertainty_score":0.006629586},"labels":[],"label_agreement":null},{"id":"W2039373513","doi":"10.1016/j.bmcl.2014.04.005","title":"A chiral benzoylthiourea–pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China","keywords":"Pyrrolidine; Chemistry; Enantioselective synthesis; Catalysis; Michael reaction; Organic chemistry; Ketone; Enone","score_opus":0.008438392186086045,"score_gpt":0.21397764278173423,"score_spread":0.20553925059564818,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2039373513","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.939299,0.004667605,0.027679097,0.00084767945,0.00059821707,0.00020970276,0.0004210442,0.0008661858,0.025411433],"genre_scores_gemma":[0.9905466,0.0013558338,0.0034559916,0.000064748485,0.00007013911,0.000026483567,0.00019744883,0.000057639092,0.004225106],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997547,0.00003681576,0.000024704443,0.000034700246,0.00007273674,0.00007634727],"domain_scores_gemma":[0.9999155,0.0000126884415,0.00001556537,0.000010551207,0.000014637046,0.00003103812],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038318933,0.0005258507,0.00041289,0.00049273483,0.00033816491,0.00047724432,0.0007662964,0.0005328582,0.001708963],"category_scores_gemma":[0.00031766683,0.0002931237,0.0002016107,0.0003586108,0.00029976663,0.00037955635,0.00043983306,0.0007537208,0.0012789889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047439,0.00024304408,0.00036280314,0.0003490565,0.000037732592,0.0008183353,0.00013799073,0.0010129628,0.9587729,0.00283073,0.0019497207,0.033010364],"study_design_scores_gemma":[0.00013066095,0.00057347986,0.0010041088,0.00001837418,0.000048637936,0.0005071395,0.000021707425,0.004766991,0.982165,0.00024269895,0.010485225,0.000036068614],"about_ca_topic_score_codex":0.0016228558,"about_ca_topic_score_gemma":0.0027167846,"teacher_disagreement_score":0.001708963,"about_ca_system_score_codex":0.0008895429,"about_ca_system_score_gemma":0.00060386275,"threshold_uncertainty_score":0.00645411},"labels":[],"label_agreement":null},{"id":"W2039456642","doi":"10.1016/s0960-894x(01)00549-2","title":"Synthesis of N-propargylphenelzine and analogues as neuroprotective agents","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroprotection; Chemistry; Monoamine oxidase; Stereochemistry; Chemical synthesis; Pharmacology; Biochemistry; In vitro; Enzyme","score_opus":0.01433609821259553,"score_gpt":0.23890611804250758,"score_spread":0.22457001982991204,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2039456642","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9619479,0.0079349,0.012275774,0.00040995202,0.000210602,0.0003244817,0.00092424906,0.0002342408,0.015737899],"genre_scores_gemma":[0.9830178,0.0036665716,0.0055027483,0.000089124536,0.00002675639,0.000102297236,0.00052335614,0.000013793135,0.0070575634],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999428,0.000009705071,0.0000052337755,0.000008924918,0.0000117624595,0.00002157139],"domain_scores_gemma":[0.99996233,0.0000053790022,0.0000085043885,0.0000052182336,0.000005719833,0.000012890999],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014957944,0.00025649433,0.0003264918,0.0002071123,0.0001332673,0.00020022086,0.00045275048,0.00027770962,0.0019687666],"category_scores_gemma":[0.00013174115,0.00013667135,0.00016586947,0.0001980327,0.00016831458,0.00030041923,0.00017862282,0.00041353228,0.00046024623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010625098,0.00020277002,0.00012982158,0.00037997199,0.00004252597,0.00068744284,0.00009204895,0.0014154428,0.964262,0.0035038544,0.0008699254,0.02735171],"study_design_scores_gemma":[0.00021478061,0.0016334794,0.00087113667,0.000014696513,0.000046306923,0.000429637,0.000019563262,0.0009870194,0.97857946,0.00035264838,0.016827708,0.000023614075],"about_ca_topic_score_codex":0.0005455116,"about_ca_topic_score_gemma":0.00084796036,"teacher_disagreement_score":0.0019687666,"about_ca_system_score_codex":0.00024091813,"about_ca_system_score_gemma":0.00026446898,"threshold_uncertainty_score":0.006586194},"labels":[],"label_agreement":null},{"id":"W2039558908","doi":"10.1016/j.bmcl.2011.05.017","title":"A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: Synthesis, biological evaluation and nitric oxide release studies","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Prodrug; Chemistry; Nitric oxide; Moiety; Stereochemistry; In vivo; Biochemistry; Organic chemistry","score_opus":0.060770067757296334,"score_gpt":0.27610682514803836,"score_spread":0.21533675739074204,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2039558908","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.986174,0.0015913761,0.007812967,0.00010679608,0.000069165995,0.00012513381,0.00018726324,0.00006855206,0.0038647458],"genre_scores_gemma":[0.990458,0.00049967645,0.005339533,0.000046167035,0.000010123935,0.000052123272,0.00017081047,0.0000067236374,0.0034169166],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994504,0.00000925678,0.000004180028,0.000014195873,0.000013167694,0.000014186347],"domain_scores_gemma":[0.99996054,0.0000073961296,0.000010074855,0.0000048755255,0.000004778808,0.000012337827],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018392954,0.00019687993,0.00020258228,0.00011482076,0.00009032302,0.00007613297,0.0002813243,0.00022485114,0.00046699893],"category_scores_gemma":[0.00009131688,0.000087550405,0.00011059263,0.000059856866,0.00010338526,0.00012066483,0.00008631466,0.00021174237,0.00018454564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013849633,0.000054598444,0.000051263596,0.00003065743,0.0000028467568,0.00011203151,0.000013855321,0.00015770464,0.99634355,0.00015806752,0.00004105827,0.0028958465],"study_design_scores_gemma":[0.00007029983,0.0015704035,0.0005550133,0.0000032540988,0.000012391344,0.00028399055,0.000006021513,0.00047105414,0.9951853,0.000028455268,0.0018090935,0.000004803013],"about_ca_topic_score_codex":0.00029203197,"about_ca_topic_score_gemma":0.00059775537,"teacher_disagreement_score":0.00046699893,"about_ca_system_score_codex":0.00016643395,"about_ca_system_score_gemma":0.00017087914,"threshold_uncertainty_score":0.0015622973},"labels":[],"label_agreement":null},{"id":"W2039721727","doi":"10.1016/j.bmcl.2011.09.126","title":"[18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Synthon; Cycloaddition; Chemistry; Azide; Alkyne; Combinatorial chemistry; Peptide; Radiosynthesis; Catalysis; Yield (engineering); Conjugate; Organic chemistry; Biochemistry","score_opus":0.05027344260843162,"score_gpt":0.25053244027872096,"score_spread":0.20025899767028935,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2039721727","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90108407,0.007198096,0.07033585,0.00092849246,0.00037037817,0.0002328255,0.00083699555,0.0009024551,0.018110843],"genre_scores_gemma":[0.96126866,0.0021681131,0.027615104,0.00013304362,0.000083679886,0.00007616453,0.0006326585,0.00008632028,0.007936295],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982005,0.00003449234,0.000010289053,0.000046107274,0.00003286144,0.000056272595],"domain_scores_gemma":[0.9999299,0.00001787263,0.000014092711,0.0000087010585,0.0000086383125,0.000020851445],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037380363,0.00068011606,0.00033530698,0.00033105732,0.00023901684,0.00046699654,0.0005207545,0.0005143792,0.0014945221],"category_scores_gemma":[0.00017885462,0.0002996992,0.00016361097,0.00019413614,0.00030350508,0.00038967704,0.00037059092,0.00058750605,0.0006920904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001840315,0.000026859328,0.00008468868,0.00006408166,0.0000057847997,0.00021927204,0.000026421287,0.00018218363,0.9938784,0.00083182845,0.00031964623,0.00417682],"study_design_scores_gemma":[0.0000319033,0.000113544294,0.00025511143,0.0000021222415,0.000009660823,0.0003934784,0.000005072388,0.00053659704,0.9934842,0.00007102927,0.005087899,0.000009374813],"about_ca_topic_score_codex":0.0012505619,"about_ca_topic_score_gemma":0.0021537123,"teacher_disagreement_score":0.0014945221,"about_ca_system_score_codex":0.00062919344,"about_ca_system_score_gemma":0.00034900047,"threshold_uncertainty_score":0.004999697},"labels":[],"label_agreement":null},{"id":"W2039939646","doi":"10.1016/j.bmcl.2011.11.069","title":"Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Trace Elements in Health","field":"Nursing","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Genome British Columbia","keywords":"Chemistry; DMT1; Transporter; Divalent metal; Metal; Divalent; Biological activity; Stereochemistry; Chemical synthesis; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry","score_opus":0.07084361079907275,"score_gpt":0.28875253519103,"score_spread":0.21790892439195725,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2039939646","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9859948,0.0072475555,0.0029700429,0.00016216942,0.000068762136,0.0001512022,0.00047540717,0.00010437455,0.0028256911],"genre_scores_gemma":[0.99158984,0.0032623762,0.0026527825,0.000058741338,0.000013631452,0.000037267222,0.00043230286,0.000011414819,0.0019416948],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999155,0.000019462077,0.000007371482,0.000013564399,0.000018546507,0.000025557178],"domain_scores_gemma":[0.99992764,0.000014394952,0.000015888465,0.0000085264255,0.000016902219,0.000016607957],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018778292,0.00021875455,0.00025390572,0.00018246836,0.0002371023,0.000175596,0.00046082964,0.0003368839,0.0013758445],"category_scores_gemma":[0.00024228064,0.00014759465,0.0002017253,0.00024453548,0.00014484982,0.00019563234,0.00011899509,0.0003733275,0.0002693533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005659591,0.00015485444,0.00016162207,0.00015746788,0.000019049845,0.00023840676,0.000059573733,0.00048325534,0.990529,0.0002633354,0.00020845832,0.0071589523],"study_design_scores_gemma":[0.00018994644,0.0031681377,0.001399596,0.000013626347,0.00005777894,0.00044814477,0.00003332464,0.0009404857,0.98746616,0.000052300875,0.006217037,0.000013364484],"about_ca_topic_score_codex":0.0010634972,"about_ca_topic_score_gemma":0.0021454939,"teacher_disagreement_score":0.0013758445,"about_ca_system_score_codex":0.000251069,"about_ca_system_score_gemma":0.00022899131,"threshold_uncertainty_score":0.0046026707},"labels":[],"label_agreement":null},{"id":"W2040149023","doi":"10.1016/s0960-894x(01)00746-6","title":"Studies toward the discovery of the next generation of antidepressants. Part 2: Incorporating a 5-HT1A antagonist component into a class of serotonin reuptake inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Reuptake inhibitor; Serotonin; Pharmacology; Antagonist; Serotonin Uptake Inhibitors; Serotonin reuptake inhibitor; Fluoxetine; Biochemistry; Medicine; Receptor","score_opus":0.12793188557903082,"score_gpt":0.2887453929941638,"score_spread":0.16081350741513298,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040149023","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7109752,0.20857175,0.034100696,0.013147286,0.00087768055,0.0011362222,0.00066209934,0.00019619834,0.030332824],"genre_scores_gemma":[0.6900082,0.24418344,0.037973616,0.0077154157,0.0006266908,0.00047358187,0.00079159293,0.00005199615,0.018175365],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986494,0.000042777574,0.000008081101,0.000018427572,0.000030192277,0.00003552143],"domain_scores_gemma":[0.9998863,0.000038056573,0.000017247567,0.000011156838,0.000021942222,0.000025288698],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054434064,0.0004078699,0.0004189518,0.00023036236,0.00022334844,0.0006003364,0.0005972608,0.0006598762,0.0047995974],"category_scores_gemma":[0.00040440593,0.00016131875,0.0005012361,0.00015951217,0.00037256413,0.0007600587,0.00023793204,0.0007766829,0.00092982466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018670288,0.0012121651,0.0013396266,0.0015476869,0.00018394378,0.0006675912,0.0002807438,0.0020173588,0.755751,0.015723178,0.0056024967,0.21380712],"study_design_scores_gemma":[0.0020674814,0.026728531,0.021761926,0.0006021874,0.0007674054,0.0039121886,0.00040030025,0.005720167,0.6111572,0.012021474,0.3147385,0.00012260646],"about_ca_topic_score_codex":0.00089424965,"about_ca_topic_score_gemma":0.0016999074,"teacher_disagreement_score":0.0047995974,"about_ca_system_score_codex":0.000516907,"about_ca_system_score_gemma":0.00047550836,"threshold_uncertainty_score":0.0160563},"labels":[],"label_agreement":null},{"id":"W2040334851","doi":"10.1016/j.bmcl.2012.04.111","title":"The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Amine oxidase; Amine gas treating; Diamine oxidase; Amine oxidase (copper-containing); Semicarbazide; Selectivity; Enzyme; Stereochemistry; Diamine; Biochemistry; Structure–activity relationship; Enzyme inhibitor; Combinatorial chemistry; In vitro; Organic chemistry; Catalysis","score_opus":0.005147129034319806,"score_gpt":0.18961625983582855,"score_spread":0.18446913080150876,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040334851","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95512134,0.019409884,0.017945683,0.0004738731,0.00016760932,0.00013781711,0.00029436755,0.00025909825,0.0061903656],"genre_scores_gemma":[0.98309547,0.007624658,0.0050673503,0.00013904063,0.000039919552,0.00006697168,0.0004694652,0.00001820084,0.0034789215],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999163,0.000009463924,0.0000042605693,0.000012564521,0.000023595916,0.000033746415],"domain_scores_gemma":[0.99993837,0.00001098312,0.000016929309,0.0000054209004,0.000013299174,0.000014901514],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021275526,0.000377138,0.00026220808,0.00017075372,0.00012900589,0.00025564275,0.00038920314,0.00030609305,0.00065515726],"category_scores_gemma":[0.00017312466,0.00015038633,0.00021832157,0.00009538635,0.00017669561,0.00020394415,0.00017335625,0.00064286595,0.00027110448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019073297,0.00013705918,0.0002459773,0.00008020519,0.000015831822,0.00013494008,0.00003642036,0.00044159088,0.9702664,0.00076772936,0.00034641815,0.02733659],"study_design_scores_gemma":[0.00013097397,0.0010845013,0.0015664573,0.000008299207,0.0000397917,0.000623184,0.000013092209,0.0018369067,0.98313314,0.00012783948,0.011423504,0.000012215413],"about_ca_topic_score_codex":0.0004685788,"about_ca_topic_score_gemma":0.001330602,"teacher_disagreement_score":0.00065515726,"about_ca_system_score_codex":0.00031170336,"about_ca_system_score_gemma":0.00024854293,"threshold_uncertainty_score":0.002261579},"labels":[],"label_agreement":null},{"id":"W2040504611","doi":"10.1016/j.bmcl.2011.10.070","title":"Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Linker; Chemistry; Pharmacokinetics; Stearoyl-CoA Desaturase; Pharmacology; Pharmacodynamics; Drug discovery; In vivo; Biochemistry; Gene; Biology; Genetics","score_opus":0.012124239653205604,"score_gpt":0.21414230754467659,"score_spread":0.20201806789147098,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040504611","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9188864,0.016398128,0.03455072,0.0010516698,0.00032155,0.00047598418,0.0016910925,0.0006487336,0.02597577],"genre_scores_gemma":[0.9655199,0.0121041415,0.010597877,0.00039154186,0.000046754805,0.00013255957,0.0010127533,0.00003732573,0.010157171],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995005,0.0000062334298,0.0000033922684,0.000009413456,0.000008996648,0.000021974176],"domain_scores_gemma":[0.99995553,0.000006831832,0.000011833291,0.0000029227,0.0000068051904,0.000016078302],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020082697,0.00044695806,0.00021580287,0.00024660124,0.00012348604,0.00023747582,0.00037713783,0.0002256757,0.0018909745],"category_scores_gemma":[0.00014353266,0.00015644544,0.00017044222,0.0001618937,0.00014711762,0.00028656816,0.00027700886,0.0004420775,0.0005129143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00079802284,0.0003739915,0.00056167925,0.00046561492,0.000054273878,0.0007317069,0.00015531608,0.0051046023,0.92096645,0.008317722,0.002892641,0.059578046],"study_design_scores_gemma":[0.0005131462,0.0048241136,0.0020956623,0.00007736164,0.00012782641,0.0007685341,0.000076003,0.0040884693,0.9032375,0.0012892882,0.08283669,0.00006538123],"about_ca_topic_score_codex":0.00042803906,"about_ca_topic_score_gemma":0.0017989717,"teacher_disagreement_score":0.0018909745,"about_ca_system_score_codex":0.0003904758,"about_ca_system_score_gemma":0.0002716605,"threshold_uncertainty_score":0.00632596},"labels":[],"label_agreement":null},{"id":"W2040974763","doi":"10.1016/j.bmcl.2011.03.085","title":"New indole amide derivatives as potent CRTH2 receptor antagonists","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Indole test; Amide; Receptor; Chemical synthesis; Bioavailability; Carboxamide; Stereochemistry; Selectivity; Pharmacology; Combinatorial chemistry; In vitro; Biochemistry","score_opus":0.017250214240793302,"score_gpt":0.23917216639484012,"score_spread":0.2219219521540468,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040974763","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9034122,0.042978868,0.0097088255,0.0010112767,0.00075124006,0.00043820968,0.0019599728,0.0005814001,0.039157946],"genre_scores_gemma":[0.9664297,0.014204166,0.0036199416,0.0005176863,0.00017970591,0.00013310768,0.0011502188,0.000045820303,0.013719533],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992955,0.000015645359,0.000003833007,0.000008879831,0.000013233595,0.000028900477],"domain_scores_gemma":[0.99996746,0.0000055608193,0.0000056575927,0.000002998124,0.000003630118,0.00001475454],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025268423,0.00038485482,0.0004183506,0.00021335206,0.00019745613,0.00027560027,0.00041017035,0.00028382652,0.004306336],"category_scores_gemma":[0.000113627335,0.00017799987,0.00022190184,0.00015577383,0.00016422711,0.00024907742,0.00024439703,0.00075585564,0.0008484449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0025419476,0.00044592426,0.00040067578,0.0005124775,0.0000682389,0.0008757332,0.00020605008,0.0019941237,0.9300347,0.0026892803,0.004222953,0.05600795],"study_design_scores_gemma":[0.0036959734,0.02401439,0.010606652,0.00014787434,0.00032074403,0.0026769445,0.00017637498,0.0054306183,0.7980267,0.0011240866,0.15362929,0.00015040541],"about_ca_topic_score_codex":0.0004519189,"about_ca_topic_score_gemma":0.0017036799,"teacher_disagreement_score":0.004306336,"about_ca_system_score_codex":0.00024739062,"about_ca_system_score_gemma":0.00015887342,"threshold_uncertainty_score":0.014406145},"labels":[],"label_agreement":null},{"id":"W2042197305","doi":"10.1016/j.bmcl.2010.01.139","title":"Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Peptidomimetic; Stereochemistry; Peptide bond; Hydrogen bond; Carboxylic acid; Amide; Selectivity; Carboxamide; Lactam; Combinatorial chemistry; Molecular model; Peptide; Molecule; Biochemistry; Organic chemistry","score_opus":0.006751061924976459,"score_gpt":0.20552127176887047,"score_spread":0.198770209843894,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042197305","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91118014,0.005946566,0.0678769,0.00061525154,0.00025579298,0.0009285592,0.0012494856,0.00041350728,0.011533767],"genre_scores_gemma":[0.9483989,0.004178538,0.039874416,0.00022209618,0.000045814963,0.00029478376,0.001201498,0.00006252805,0.00572148],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998994,0.000014889612,0.000010200886,0.000019505282,0.00003096332,0.000024986588],"domain_scores_gemma":[0.9999453,0.0000075100015,0.000016420396,0.0000063656917,0.000009909894,0.000014451313],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022159844,0.00049010536,0.00033718257,0.00019585053,0.0002429656,0.0005451483,0.00069935014,0.00040609782,0.0015815136],"category_scores_gemma":[0.00021973245,0.0002981315,0.0003961169,0.00018029237,0.00019161575,0.00031648064,0.0002386086,0.0008520891,0.00059421797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034298553,0.00014666155,0.00010303549,0.00013193907,0.000034265875,0.00033062417,0.000037931542,0.0036563128,0.9822233,0.0014625132,0.0003006792,0.011229724],"study_design_scores_gemma":[0.00017921776,0.00066464324,0.0002721244,0.000008244259,0.00004047261,0.00033946786,0.000013566301,0.0034919067,0.98594,0.0002062402,0.008831294,0.000012922532],"about_ca_topic_score_codex":0.0004297874,"about_ca_topic_score_gemma":0.0007647444,"teacher_disagreement_score":0.0015815136,"about_ca_system_score_codex":0.0005123656,"about_ca_system_score_gemma":0.00036394692,"threshold_uncertainty_score":0.005290687},"labels":[],"label_agreement":null},{"id":"W2042434678","doi":"10.1016/j.bmcl.2010.09.141","title":"Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Thrombin; Proteases; Coagulation cascade; Selectivity; Chemical synthesis; Stereochemistry; Coagulation; Serine; Combinatorial chemistry; Biochemistry; Enzyme; In vitro","score_opus":0.010943180412842254,"score_gpt":0.2308461768873875,"score_spread":0.21990299647454525,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042434678","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93614584,0.009504391,0.037883867,0.0003585112,0.00021676839,0.00040775357,0.0006198752,0.00033013066,0.014532962],"genre_scores_gemma":[0.9824822,0.002903875,0.010359241,0.00010403337,0.00002027559,0.00009898761,0.00022231892,0.000020556052,0.0037885264],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999523,0.000006737756,0.0000037641685,0.000009884941,0.000009011593,0.00001816677],"domain_scores_gemma":[0.9999635,0.0000045946967,0.000012935396,0.0000030163435,0.00000507678,0.000010728547],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011559504,0.0002685709,0.00017492338,0.00015906016,0.00014239043,0.00019606092,0.00027586948,0.00020030527,0.0011967329],"category_scores_gemma":[0.00011875434,0.00010729164,0.00019038627,0.00012211321,0.00011004958,0.00016051979,0.0001672641,0.0002782919,0.00029644338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043481978,0.000111708454,0.00021207072,0.00028595427,0.000024584439,0.00050162635,0.000115413946,0.002511975,0.96833044,0.0021744908,0.00052198383,0.024774825],"study_design_scores_gemma":[0.00017622171,0.002506054,0.0013398745,0.00003042773,0.00004725322,0.0003706796,0.000048599773,0.0041138106,0.96869344,0.00040343325,0.022241227,0.000029121027],"about_ca_topic_score_codex":0.00042794095,"about_ca_topic_score_gemma":0.0013001598,"teacher_disagreement_score":0.0011967329,"about_ca_system_score_codex":0.00027249864,"about_ca_system_score_gemma":0.00021871743,"threshold_uncertainty_score":0.004003525},"labels":[],"label_agreement":null},{"id":"W2042469334","doi":"10.1016/j.bmcl.2013.06.007","title":"N- versus O-alkylation: Utilizing NMR methods to establish reliable primary structure determinations for drug discovery","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Alkylation; Chemistry; Heteronuclear single quantum coherence spectroscopy; Regioselectivity; Drug discovery; Combinatorial chemistry; Stereochemistry; Chemical shift; Nuclear magnetic resonance spectroscopy; Organic chemistry; Catalysis; Biochemistry","score_opus":0.010570916553703659,"score_gpt":0.27304616735063647,"score_spread":0.2624752507969328,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042469334","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.73733383,0.007243368,0.23868996,0.0009746771,0.00039144207,0.000250651,0.0010978783,0.0007493369,0.013268969],"genre_scores_gemma":[0.8666909,0.0068307198,0.121037014,0.00051539345,0.00021442804,0.00012018496,0.0010221051,0.00015401708,0.0034153191],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99953973,0.00014532219,0.000027221537,0.000117300384,0.000097780816,0.0000727279],"domain_scores_gemma":[0.9988372,0.0003347062,0.00026628745,0.00022213762,0.000254822,0.0000849215],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013232689,0.00062878133,0.00028848046,0.0003346641,0.00030803983,0.00057729497,0.00042716254,0.0005131378,0.00093223655],"category_scores_gemma":[0.0023132842,0.00025208553,0.00021255187,0.00035015823,0.0007743192,0.0011643093,0.00039965764,0.0009231393,0.0005149365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046696392,0.000028989996,0.00034724537,0.00006915285,0.00001265611,0.00006061935,0.000037630685,0.00038042778,0.98243034,0.0008442808,0.00012789803,0.015193889],"study_design_scores_gemma":[0.000027316635,0.00040275056,0.0009874892,0.000014741082,0.00003784771,0.00013728168,0.000026535416,0.0031771383,0.98996276,0.0008220665,0.004386218,0.000017894503],"about_ca_topic_score_codex":0.000938239,"about_ca_topic_score_gemma":0.002960386,"teacher_disagreement_score":0.0013232689,"about_ca_system_score_codex":0.00035235647,"about_ca_system_score_gemma":0.0008570048,"threshold_uncertainty_score":0.0069981813},"labels":[],"label_agreement":null},{"id":"W2042734230","doi":"10.1016/j.bmcl.2013.03.114","title":"Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Celator Pharmaceuticals (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Zalicus","keywords":"Chemistry; Piperazine; Combinatorial chemistry; Calcium channel; Selectivity; Yield (engineering); Alcohol; Chemical synthesis; Stereochemistry; Enantioselective synthesis; Catalysis; Calcium; Organic chemistry; In vitro; Biochemistry","score_opus":0.005770202472248564,"score_gpt":0.20594040020340174,"score_spread":0.20017019773115316,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042734230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93251944,0.0044925506,0.046380274,0.00043636104,0.0001487898,0.0002076437,0.00085648586,0.0005469105,0.014411626],"genre_scores_gemma":[0.97949845,0.0024008288,0.012935933,0.000107460655,0.00003219426,0.00005978138,0.00037618724,0.000033614364,0.004555544],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999168,0.000011981087,0.0000072889047,0.000014833673,0.000017646178,0.000031475593],"domain_scores_gemma":[0.99994826,0.0000074007025,0.000019605339,0.0000065535082,0.000006305147,0.000011861361],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021923793,0.00043363482,0.00024348436,0.00015803397,0.00013102342,0.00021050176,0.00038972442,0.0002617874,0.0021971306],"category_scores_gemma":[0.00014812137,0.00014866628,0.00016785845,0.00020245096,0.00016453698,0.00040522846,0.00035079793,0.0005513035,0.0007092989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028192234,0.00009157839,0.000110482535,0.0002303484,0.000010962436,0.00028820502,0.000057299003,0.0016720656,0.975513,0.0022796816,0.0004241975,0.019040313],"study_design_scores_gemma":[0.00010108265,0.0010964123,0.00072674704,0.00001566718,0.000025748372,0.00036854448,0.000021533237,0.0024467171,0.9845524,0.0003614148,0.010261897,0.00002194944],"about_ca_topic_score_codex":0.00016968866,"about_ca_topic_score_gemma":0.00051472423,"teacher_disagreement_score":0.0021971306,"about_ca_system_score_codex":0.00021571646,"about_ca_system_score_gemma":0.00022440503,"threshold_uncertainty_score":0.007350087},"labels":[],"label_agreement":null},{"id":"W2042824575","doi":"10.1016/s0960-894x(01)00135-4","title":"In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Etoricoxib; Chemistry; In vitro; Pharmacology; CYP3A4; Metabolite; Biochemistry; Metabolism; Cytochrome P450; Biology","score_opus":0.019236830133506046,"score_gpt":0.25047714640229185,"score_spread":0.2312403162687858,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042824575","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8951234,0.021112207,0.06451504,0.0031910928,0.00048726055,0.00045826574,0.002537714,0.00021306233,0.012361864],"genre_scores_gemma":[0.9294808,0.012820308,0.04991343,0.0006120168,0.00015791,0.0002299383,0.0026000543,0.00006354462,0.004121956],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99927014,0.00042448097,0.00009676771,0.000055506363,0.00009621751,0.000056879588],"domain_scores_gemma":[0.99954623,0.00019144622,0.00007322801,0.000060616745,0.00008409864,0.00004428932],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012992041,0.00056461064,0.00057355105,0.00032103658,0.00040822872,0.001046122,0.00051602017,0.0007994442,0.0015459572],"category_scores_gemma":[0.0015529882,0.00036280564,0.0005628285,0.00036391936,0.00027908426,0.0007845628,0.00040107995,0.0009790055,0.00048652384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00192027,0.00045551706,0.0025595166,0.00024359704,0.000049120572,0.0006517117,0.00007569601,0.002327204,0.9632158,0.0008758184,0.00050033705,0.027125373],"study_design_scores_gemma":[0.00010485302,0.0050417003,0.0028060484,0.000029854591,0.00020647206,0.0018566792,0.000097440694,0.002207687,0.975468,0.00061482686,0.011533585,0.000032770844],"about_ca_topic_score_codex":0.0011379806,"about_ca_topic_score_gemma":0.0054983487,"teacher_disagreement_score":0.0015459572,"about_ca_system_score_codex":0.0003496157,"about_ca_system_score_gemma":0.00076063577,"threshold_uncertainty_score":0.0068709254},"labels":[],"label_agreement":null},{"id":"W2042940085","doi":"10.1016/s0960-894x(00)00478-9","title":"Synthesis of Glutaminyl Adenylate Analogues that are inhibitors of glutaminyl-tRNA synthetase","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Adenylate kinase; Glutamine; Glutamine synthetase; Enzyme; Biochemistry; Transfer RNA; Phosphate; Stereochemistry; Enzyme inhibitor; RNA; Amino acid; Gene","score_opus":0.008682394768930655,"score_gpt":0.20529444226702745,"score_spread":0.1966120474980968,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042940085","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95523065,0.00835489,0.013897554,0.00038202442,0.00044115394,0.00036760813,0.0010441318,0.00047776263,0.019804373],"genre_scores_gemma":[0.98647124,0.0024272068,0.00551725,0.00009463621,0.000046932928,0.00007249086,0.00076929264,0.00007111372,0.004529852],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977475,0.000049252343,0.000027758422,0.00004485208,0.000040730934,0.000062570325],"domain_scores_gemma":[0.9997429,0.00006525868,0.00006332065,0.000033564014,0.000031682575,0.00006329596],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039101462,0.0006400211,0.0006492281,0.00037021295,0.00028224522,0.0006199863,0.00061749277,0.0005846379,0.0022853655],"category_scores_gemma":[0.00044577985,0.00037310657,0.00041534504,0.00025020036,0.0002630737,0.00041871445,0.00031195366,0.000871415,0.000703679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00085668016,0.00015316452,0.00013658327,0.00018439945,0.000042643987,0.00038239133,0.00006220916,0.0020323712,0.98425585,0.0019864906,0.00036312867,0.009544215],"study_design_scores_gemma":[0.00013270322,0.0006438822,0.0002237942,0.000009584301,0.00002990917,0.0002263152,0.000009030896,0.00088201265,0.99164057,0.00011669345,0.0060709864,0.000014451134],"about_ca_topic_score_codex":0.00042653608,"about_ca_topic_score_gemma":0.0005603333,"teacher_disagreement_score":0.0022853655,"about_ca_system_score_codex":0.00042105943,"about_ca_system_score_gemma":0.00029539387,"threshold_uncertainty_score":0.007645309},"labels":[],"label_agreement":null},{"id":"W2043014859","doi":"10.1016/s0960-894x(01)00172-x","title":"Probing the transducin nucleotide binding site with GDP analogues","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Transducin; Chemistry; Heterotrimeric G protein; Nucleotide; Stereochemistry; Affinities; Moiety; Biochemistry; Binding site; G protein; Signal transduction","score_opus":0.0072087280276219344,"score_gpt":0.20155174662712544,"score_spread":0.1943430185995035,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2043014859","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9895768,0.0005193592,0.0045058425,0.00028826363,0.00004432359,0.00003984399,0.00016462685,0.000041172927,0.0048197727],"genre_scores_gemma":[0.99319345,0.0005309925,0.0030343898,0.00011215482,0.00001159153,0.000035589044,0.00034996745,0.00003217389,0.0026996646],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997633,0.0000683232,0.000010290912,0.000037245576,0.000049509614,0.00007136227],"domain_scores_gemma":[0.9994522,0.0003439877,0.00004157401,0.0000629551,0.00003341528,0.00006599387],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003790469,0.00030624573,0.0003421388,0.00020884286,0.00037648657,0.00050804514,0.00063351233,0.0008690266,0.002821483],"category_scores_gemma":[0.0008366777,0.00026537044,0.00015838578,0.0002510776,0.00048435113,0.00038120087,0.0003925994,0.0018169095,0.00038266127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00083595345,0.00013572657,0.00029311707,0.0000863221,0.000012373817,0.00050296023,0.00014516008,0.001529071,0.9898447,0.0028379203,0.00019118148,0.0035856701],"study_design_scores_gemma":[0.00008998181,0.0002690948,0.0006454572,0.000008988245,0.000012543468,0.0002184202,0.00007385295,0.0025000873,0.9929107,0.0003722406,0.0028828182,0.00001574818],"about_ca_topic_score_codex":0.0016126658,"about_ca_topic_score_gemma":0.0017349123,"teacher_disagreement_score":0.002821483,"about_ca_system_score_codex":0.00082805863,"about_ca_system_score_gemma":0.00041463735,"threshold_uncertainty_score":0.009438753},"labels":[],"label_agreement":null},{"id":"W2043430944","doi":"10.1016/j.bmcl.2008.01.105","title":"Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Substituent; Arachidonate 5-lipoxygenase; Chemical synthesis; Stereochemistry; Potency; Aryl; Enzyme inhibitor; Lipoxygenase; Enzyme; In vitro; Biochemistry; Alkyl; Organic chemistry","score_opus":0.01113066260957208,"score_gpt":0.2126574527520113,"score_spread":0.20152679014243924,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2043430944","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9600712,0.018701768,0.0070320996,0.0002845139,0.00029053385,0.00012481853,0.00045369664,0.00030790025,0.012733403],"genre_scores_gemma":[0.98298615,0.005857727,0.004403955,0.00024157284,0.000050159586,0.0000869717,0.0004198515,0.000030412824,0.0059233154],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999211,0.000016171782,0.0000064724554,0.000012856998,0.00001885455,0.000024571416],"domain_scores_gemma":[0.99997723,0.0000035914832,0.0000063719626,0.0000025315455,0.0000033680737,0.0000069447187],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013240092,0.00028315838,0.00030230748,0.00021474251,0.00012815463,0.00020413422,0.0003509173,0.00024889698,0.0015802205],"category_scores_gemma":[0.00008821842,0.00013259638,0.00009495853,0.00017411298,0.00012844347,0.0002194567,0.00018075523,0.00038128372,0.00044263978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080363936,0.000106186926,0.00008995446,0.00017625302,0.000011654996,0.0001495265,0.000044598266,0.0006750031,0.9792966,0.00091950514,0.0005506397,0.017176373],"study_design_scores_gemma":[0.0002886333,0.0019365362,0.001473688,0.00002445961,0.000036620306,0.00054397597,0.000032949083,0.0023168796,0.9754573,0.00022989305,0.017623605,0.000035447512],"about_ca_topic_score_codex":0.00026679234,"about_ca_topic_score_gemma":0.00089642365,"teacher_disagreement_score":0.0015802205,"about_ca_system_score_codex":0.00020391401,"about_ca_system_score_gemma":0.00012239357,"threshold_uncertainty_score":0.005286336},"labels":[],"label_agreement":null},{"id":"W2044021473","doi":"10.1016/j.bmcl.2014.05.054","title":"ApoE secretion modulating bromotyrosine derivative from the Australian marine sponge Callyspongia sp.","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development","funders":"Queensland Government; Australian Research Council; Griffith University; Alzheimer's Drug Discovery Foundation","keywords":"Sponge; Chemistry; Stereochemistry; Natural product; Secretion; Derivative (finance); Fractionation; Biochemistry; Organic chemistry; Biology","score_opus":0.00758388946144497,"score_gpt":0.2137846283489763,"score_spread":0.20620073888753132,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044021473","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9965603,0.0012192057,0.0006413675,0.000057918223,0.0000082796105,0.000032248434,0.00046323647,0.000028425588,0.0009890063],"genre_scores_gemma":[0.99272436,0.0016807831,0.0017062342,0.00007040449,0.0000071789354,0.000029863093,0.0013325196,0.0000097621505,0.0024388265],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999969,0.000003987143,0.0000024011097,0.0000066853577,0.000011622968,0.0000062575577],"domain_scores_gemma":[0.99995685,0.000009187549,0.000009076354,0.0000039092506,0.000007877578,0.000013169245],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006082853,0.0003424297,0.00019643609,0.00025008467,0.000116551004,0.00013601416,0.00008901172,0.00014253266,0.0006874884],"category_scores_gemma":[0.00009059249,0.000094986695,0.00018825028,0.0002198802,0.00013704694,0.00008512152,0.00017917996,0.00023656285,0.0001609006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011987496,0.000015207594,0.00026669767,0.00006044155,0.000005909119,0.0001122285,0.000014112961,0.000050233306,0.9973429,0.00000790876,0.000018920327,0.0019856093],"study_design_scores_gemma":[0.000047741098,0.0016257504,0.021544598,0.000016892945,0.000075420234,0.00071857247,0.00008309434,0.000257328,0.97215545,0.00002782765,0.003436584,0.0000106835805],"about_ca_topic_score_codex":0.0016059185,"about_ca_topic_score_gemma":0.004193479,"teacher_disagreement_score":0.0016059185,"about_ca_system_score_codex":0.00012636138,"about_ca_system_score_gemma":0.00021495865,"threshold_uncertainty_score":0.00319314},"labels":[],"label_agreement":null},{"id":"W2044044821","doi":"10.1016/j.bmcl.2012.04.013","title":"Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Wound Healing and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Potency; Kinase; Pyrazole; Pharmacology; Stereochemistry; Biochemistry; In vitro; Biology","score_opus":0.013647086239613571,"score_gpt":0.2558910673637249,"score_spread":0.24224398112411133,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044044821","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9309972,0.03076193,0.015594181,0.00094656623,0.000334257,0.00049471646,0.0010391303,0.0004233726,0.01940862],"genre_scores_gemma":[0.96863806,0.014074807,0.008441221,0.0003344327,0.00005337173,0.00015660383,0.000993748,0.000019243676,0.0072885626],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999039,0.000017007824,0.0000063262123,0.000014190295,0.000027944201,0.000030653668],"domain_scores_gemma":[0.9999505,0.000008384427,0.00001107154,0.0000046851465,0.000008704069,0.000016608845],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027725936,0.00045280723,0.00031151946,0.00030122657,0.00025017696,0.00040344094,0.0005470873,0.00036640142,0.0028027121],"category_scores_gemma":[0.00023847146,0.00020426973,0.0002683856,0.00021401669,0.00022568622,0.00033005644,0.00033596437,0.0006129929,0.0005504799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011295837,0.0006997556,0.0011094017,0.0008536968,0.00008913974,0.0013519133,0.00023995034,0.004477629,0.86167973,0.0053710127,0.0029942223,0.120003976],"study_design_scores_gemma":[0.0008141937,0.00749554,0.0055895876,0.0001462415,0.00018921516,0.002154511,0.000121436555,0.009894156,0.9062279,0.00094695773,0.066341065,0.000079177626],"about_ca_topic_score_codex":0.0007932524,"about_ca_topic_score_gemma":0.0027477017,"teacher_disagreement_score":0.0028027121,"about_ca_system_score_codex":0.0004307977,"about_ca_system_score_gemma":0.0003627173,"threshold_uncertainty_score":0.009375989},"labels":[],"label_agreement":null},{"id":"W2044125881","doi":"10.1016/s0960-894x(00)00614-4","title":"Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":78,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Pharmacophore; Chemistry; Stereochemistry; Combinatorial chemistry; Cytotoxic T cell; Cytotoxicity; In vitro; Biochemistry","score_opus":0.03024555144642733,"score_gpt":0.2661995936185067,"score_spread":0.23595404217207938,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044125881","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97066385,0.0036890018,0.009639416,0.00080236857,0.00008474405,0.00046085133,0.0003377126,0.00011524674,0.014206753],"genre_scores_gemma":[0.98197687,0.004624667,0.0069834776,0.00036569,0.00003780669,0.00007156736,0.00037752648,0.000042814536,0.0055195326],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998379,0.000043700922,0.000010368501,0.000024122091,0.000036542366,0.000047295875],"domain_scores_gemma":[0.9998596,0.00004173475,0.000022982666,0.000019632,0.000034142722,0.000022002843],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004705552,0.0003436571,0.00039336624,0.00019229752,0.0002814383,0.00037057305,0.0005193969,0.0003504067,0.0021041157],"category_scores_gemma":[0.00052994245,0.00016775956,0.00024305389,0.00019568253,0.0004535857,0.00040585457,0.0003005367,0.000851956,0.00047532163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016339017,0.0005753389,0.0006470646,0.00033061375,0.00004426428,0.00060852995,0.00021416986,0.0066504283,0.949605,0.0066283178,0.0007451963,0.0323172],"study_design_scores_gemma":[0.00051006995,0.005430135,0.0017345661,0.00003323483,0.00010120968,0.0012918869,0.00009802546,0.004610362,0.9576879,0.0007263913,0.027743127,0.00003289334],"about_ca_topic_score_codex":0.0016323957,"about_ca_topic_score_gemma":0.0016952697,"teacher_disagreement_score":0.0021041157,"about_ca_system_score_codex":0.00040969087,"about_ca_system_score_gemma":0.00059052603,"threshold_uncertainty_score":0.007038951},"labels":[],"label_agreement":null},{"id":"W2044699816","doi":"10.1016/j.bmcl.2009.02.075","title":"Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Sulfamide; HDAC1; Chemistry; Lysine; HDAC6; Histone deacetylase; Enzyme; Biochemistry; Metabolic stability; Potency; HDAC8; Hydroxamic acid; Pharmacology; Stereochemistry; Histone; Amino acid; In vitro; Organic chemistry","score_opus":0.013482165707554136,"score_gpt":0.2914858391354335,"score_spread":0.2780036734278794,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044699816","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95593894,0.0112473685,0.01390504,0.00030858375,0.00018751496,0.00042741158,0.00091164006,0.00019797427,0.016875606],"genre_scores_gemma":[0.9800091,0.008191999,0.006078503,0.00009489102,0.000042115942,0.00008469938,0.00061190303,0.000024913423,0.0048618405],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998735,0.000026550993,0.000014073987,0.000015561602,0.00003085187,0.000039395618],"domain_scores_gemma":[0.9999136,0.000011875029,0.0000165732,0.000009736372,0.000024441055,0.000023818502],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042103455,0.00047633034,0.00033116306,0.0003374305,0.0002251208,0.00021358412,0.00039302444,0.00028433572,0.0018092257],"category_scores_gemma":[0.00021844149,0.00015541434,0.0002914142,0.00025163888,0.00019359472,0.00030132165,0.00020980567,0.00033191213,0.0004021048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009150721,0.0005039714,0.0003966022,0.000455819,0.00006724556,0.0005381253,0.00015899188,0.0032724116,0.95680285,0.0018215252,0.0007706404,0.0342967],"study_design_scores_gemma":[0.00023365044,0.0048418622,0.0010234612,0.000026753036,0.00007740215,0.0002841041,0.000042048316,0.0011170639,0.9771131,0.00016178073,0.015059461,0.00001924475],"about_ca_topic_score_codex":0.0006746125,"about_ca_topic_score_gemma":0.0012996813,"teacher_disagreement_score":0.0018092257,"about_ca_system_score_codex":0.00031181335,"about_ca_system_score_gemma":0.00033493605,"threshold_uncertainty_score":0.006052494},"labels":[],"label_agreement":null},{"id":"W2044747561","doi":"10.1016/j.bmcl.2004.08.018","title":"HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Biotechnology Research Institute","funders":"Ministry of Education, India; Ministry of Earth Sciences","keywords":"NS5B; Chemistry; Polymerase; Stereochemistry; Sulfonamide; RNA polymerase; Hepatitis C virus; Two-dimensional nuclear magnetic resonance spectroscopy; Virology; Enzyme; Biochemistry; RNA; Virus; Hepacivirus; Biology; Gene","score_opus":0.01250955427620164,"score_gpt":0.2572231690931813,"score_spread":0.24471361481697967,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044747561","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.992274,0.000451169,0.0029295287,0.00015824192,0.000054767686,0.000024083503,0.00011287167,0.00006295557,0.003932392],"genre_scores_gemma":[0.9938306,0.00030296895,0.0014375799,0.000057603906,0.0000070112637,0.000014604328,0.00020060042,0.000024200084,0.0041249027],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999168,0.000012814919,0.000003421063,0.00001809478,0.00002018715,0.000028643528],"domain_scores_gemma":[0.99996364,0.000008912959,0.00000954275,0.0000052973583,0.0000032861633,0.000009263311],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016124277,0.0003045352,0.00025969397,0.00006227974,0.00017575681,0.00030982055,0.00043075846,0.00022539355,0.0015519763],"category_scores_gemma":[0.00015016395,0.00014384325,0.00013286699,0.00006464175,0.00020713382,0.0001826487,0.00018820542,0.0006228809,0.00020812567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008638034,0.00016519647,0.0002806712,0.00009807525,0.000042580195,0.00033824684,0.00011501972,0.004595406,0.9870799,0.0017716379,0.0005239914,0.0041253455],"study_design_scores_gemma":[0.00017579367,0.0004440242,0.0010215463,0.000012077945,0.000024219546,0.0001322425,0.000045139368,0.02290292,0.969674,0.00021651755,0.0053113094,0.000040090315],"about_ca_topic_score_codex":0.0027377426,"about_ca_topic_score_gemma":0.0040287357,"teacher_disagreement_score":0.0027377426,"about_ca_system_score_codex":0.0006677964,"about_ca_system_score_gemma":0.0003557873,"threshold_uncertainty_score":0.0054436326},"labels":[],"label_agreement":null},{"id":"W2044837518","doi":"10.1016/j.bmcl.2009.09.008","title":"Scaffold-based design and synthesis of potent N-type calcium channel blockers","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Calgary","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Flunarizine; Chemistry; Calcium channel; hERG; N-type calcium channel; Pharmacology; Potassium channel; Calcium; Voltage-dependent calcium channel; Analgesic; L-type calcium channel; T-type calcium channel; Channel blocker; Ion channel; Receptor; Biophysics; Biochemistry","score_opus":0.015969251229904422,"score_gpt":0.22853525939868377,"score_spread":0.21256600816877935,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044837518","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8695508,0.009258385,0.09242914,0.00067406654,0.00030853527,0.000796107,0.001020387,0.00088758045,0.02507503],"genre_scores_gemma":[0.9577776,0.0055946214,0.030837812,0.00016048276,0.0000450727,0.00016355516,0.00073105114,0.00005595891,0.004633884],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999057,0.00001787194,0.000009171331,0.000018181103,0.000019052288,0.00002993752],"domain_scores_gemma":[0.99993694,0.000010784352,0.000017009244,0.000006942068,0.000011721284,0.000016552327],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002518436,0.00047879238,0.00036941207,0.0002845475,0.0002585112,0.00043712207,0.0005708835,0.0003148276,0.0014952944],"category_scores_gemma":[0.00025979083,0.00018477664,0.00028002163,0.00022605213,0.00018916631,0.0003522255,0.00034550313,0.00044624452,0.0006151763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004922548,0.00030534063,0.000231202,0.00046047976,0.000045231915,0.0006373702,0.000152733,0.0065611643,0.94631547,0.0058008684,0.0011751555,0.037822645],"study_design_scores_gemma":[0.00040833905,0.0030611209,0.0005436341,0.00005885403,0.000094253286,0.0005318982,0.000074150834,0.007189245,0.9544886,0.0012387636,0.032266304,0.000044874752],"about_ca_topic_score_codex":0.0003628648,"about_ca_topic_score_gemma":0.0013899633,"teacher_disagreement_score":0.0014952944,"about_ca_system_score_codex":0.00031234027,"about_ca_system_score_gemma":0.0004459067,"threshold_uncertainty_score":0.00500226},"labels":[],"label_agreement":null},{"id":"W2044839967","doi":"10.1016/j.bmcl.2010.09.051","title":"Sequential cytotoxicity: A theory examined using a series of 3,5-bis(benzylidene)-1-diethylphosphono-4-oxopiperidines and related phosphonic acids","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Organophosphorus compounds synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Cytotoxicity; Chemistry; Cytotoxic T cell; Stereochemistry; Cell culture; Apoptosis; Toxicity; DNA fragmentation; Aryl; Fragmentation (computing); Chemical synthesis; In vitro; Biochemistry; Programmed cell death; Organic chemistry","score_opus":0.009383538204078551,"score_gpt":0.21055535898072755,"score_spread":0.201171820776649,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044839967","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98131716,0.0034037768,0.0078090676,0.00014064534,0.00009752397,0.0001908822,0.00041071558,0.00010461378,0.006525579],"genre_scores_gemma":[0.9912936,0.0024191868,0.0025380184,0.00004678521,0.00001891195,0.00008238278,0.00031554236,0.000014071226,0.003271443],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984336,0.00003214654,0.000015112285,0.00003374556,0.00004030142,0.000035303176],"domain_scores_gemma":[0.9997843,0.00007506971,0.000038273534,0.000039716815,0.000042967673,0.000019665204],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027175221,0.00041297288,0.0003755648,0.00020293762,0.00018983449,0.00032152914,0.00040920725,0.00026959094,0.0019645465],"category_scores_gemma":[0.00035843818,0.00012964875,0.00024321755,0.0002597497,0.00020817963,0.0003975368,0.00020396242,0.00043453294,0.0004494281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007681919,0.00023885559,0.0006132602,0.00022178027,0.00002384085,0.00012701152,0.000048742128,0.001235019,0.98342174,0.00041368662,0.00020627292,0.012681667],"study_design_scores_gemma":[0.00003436999,0.002965936,0.0007908148,0.000008341909,0.000026533246,0.00015700629,0.000021420086,0.0009800801,0.9930276,0.00008064468,0.0019028344,0.000004427837],"about_ca_topic_score_codex":0.0007640368,"about_ca_topic_score_gemma":0.0016151937,"teacher_disagreement_score":0.0019645465,"about_ca_system_score_codex":0.0003754851,"about_ca_system_score_gemma":0.00033898104,"threshold_uncertainty_score":0.0065720677},"labels":[],"label_agreement":null},{"id":"W2044878319","doi":"10.1016/j.bmcl.2009.02.052","title":"Simple and convenient radiolabeling of proteins using a prelabeling-approach with thiol-DOTA","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Chemistry; DOTA; Thiol; Simple (philosophy); Combinatorial chemistry; Chelation; Biochemistry; Organic chemistry","score_opus":0.01979797997512315,"score_gpt":0.27153298912170515,"score_spread":0.251735009146582,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044878319","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.55223715,0.008138714,0.42483053,0.0012351994,0.0005080733,0.0005714247,0.0010228719,0.0031094798,0.008346483],"genre_scores_gemma":[0.7682518,0.004139039,0.20777136,0.00039638014,0.00009958436,0.00031386735,0.0016628127,0.0004673819,0.016897835],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99971,0.000040112507,0.000023736224,0.000082914594,0.00008343263,0.000059732527],"domain_scores_gemma":[0.9998447,0.00003746257,0.000023436503,0.000040246476,0.000022432881,0.000031731368],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004216595,0.0007224552,0.00055379537,0.00029739027,0.0005059871,0.00043917366,0.00067620043,0.00060475664,0.0017079553],"category_scores_gemma":[0.0002344537,0.0005224205,0.00044322122,0.0002293864,0.0003776379,0.0005331417,0.00068261154,0.0012178255,0.0013899191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000053942917,0.000014055515,0.000033232885,0.00006738667,0.0000066612924,0.000047807505,0.000019575082,0.00004530396,0.99708337,0.00028608556,0.00011910488,0.0022234358],"study_design_scores_gemma":[0.0000075706607,0.000060000475,0.00018833026,0.0000023019734,0.000010007883,0.00023318332,0.000006943519,0.00032449997,0.99518895,0.000087401146,0.0038840526,0.0000068551813],"about_ca_topic_score_codex":0.0005056365,"about_ca_topic_score_gemma":0.0012846384,"teacher_disagreement_score":0.0017079553,"about_ca_system_score_codex":0.00047672354,"about_ca_system_score_gemma":0.00038499004,"threshold_uncertainty_score":0.0057136416},"labels":[],"label_agreement":null},{"id":"W2044910404","doi":"10.1016/s0960-894x(00)00636-3","title":"Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and pharmacological studies","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Bicyclic molecule; Chemistry; Thrombin; Cyclohexylamine; In vivo; Lactam; Discovery and development of direct thrombin inhibitors; Selectivity; Stereochemistry; Chemical synthesis; In vitro; Pharmacology; Biochemistry; Organic chemistry; Platelet; Immunology","score_opus":0.011773360847938424,"score_gpt":0.22109234401005576,"score_spread":0.20931898316211733,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2044910404","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.81123424,0.13091794,0.014298617,0.0015716804,0.00061690103,0.000508962,0.0014122244,0.000634111,0.038805276],"genre_scores_gemma":[0.904862,0.061280444,0.0037704646,0.00092874106,0.00030428587,0.00024453786,0.0018409165,0.000046231864,0.026722394],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998915,0.000019431418,0.0000065478453,0.000010955292,0.000024105608,0.000047411995],"domain_scores_gemma":[0.99996865,0.0000072051434,0.000005446046,0.0000036512604,0.0000039551287,0.000011027039],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020684075,0.00042914282,0.00043493282,0.00055959786,0.0001805766,0.00027216968,0.00053580885,0.00028639965,0.0038252247],"category_scores_gemma":[0.00017471885,0.0001917362,0.00028775007,0.00026079168,0.00024228782,0.00027381955,0.00028462973,0.0005533451,0.0010219748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037541327,0.000790149,0.0002869442,0.00068782235,0.0000667261,0.00042028056,0.00015243924,0.0018560173,0.83647335,0.0032792222,0.00562489,0.14660808],"study_design_scores_gemma":[0.002716089,0.02517235,0.008589919,0.00011484581,0.00030028645,0.0029546833,0.00006847974,0.0025455956,0.8560965,0.001761741,0.09958759,0.00009199379],"about_ca_topic_score_codex":0.00057142595,"about_ca_topic_score_gemma":0.0009769696,"teacher_disagreement_score":0.0038252247,"about_ca_system_score_codex":0.00032552335,"about_ca_system_score_gemma":0.00020788232,"threshold_uncertainty_score":0.01279664},"labels":[],"label_agreement":null},{"id":"W2045048406","doi":"10.1016/s0960-894x(01)00623-0","title":"Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Shionogi; Gen Foundation","keywords":"Chemistry; Carbohydrate; Diamine; Xylose; Platinum; Glycoside; Mannose; Aldose; Galactose; Sugar; Chelation; Stereochemistry; Arabinose; In vivo; Carbohydrate chemistry; D-Glucose; Biochemistry; Organic chemistry; Catalysis","score_opus":0.025859640704885535,"score_gpt":0.2500433064423169,"score_spread":0.2241836657374314,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2045048406","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.995404,0.00063781615,0.0013984411,0.00007493679,0.000026479058,0.000019976618,0.00011569196,0.00008106719,0.0022416716],"genre_scores_gemma":[0.99802554,0.00021204559,0.0007730028,0.000020189593,0.000004247738,0.000008248949,0.000093110604,0.000013583276,0.0008500173],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999362,0.000010477725,0.0000045621823,0.0000118261805,0.000015701426,0.000021157775],"domain_scores_gemma":[0.99995196,0.000011617904,0.000010685557,0.000009190607,0.000004417981,0.000012061001],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010751851,0.00019315866,0.00016840722,0.00009508349,0.00008689889,0.00030518684,0.0002160625,0.00019823542,0.0006577502],"category_scores_gemma":[0.00012216829,0.00012676907,0.000068562316,0.000108698136,0.00014373289,0.00013451849,0.0001233153,0.00035446964,0.0001447537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001336236,0.0000201272,0.000068986,0.000016585276,0.000002697315,0.00002705669,0.000009905892,0.000086266555,0.99795747,0.00014820493,0.00006626908,0.001462818],"study_design_scores_gemma":[0.000015551974,0.00011291166,0.00027643936,6.7235777e-7,0.0000048804613,0.000060801638,0.0000027976303,0.00029710724,0.9984597,0.000014257568,0.00075308944,0.0000018085024],"about_ca_topic_score_codex":0.00034302584,"about_ca_topic_score_gemma":0.0004752421,"teacher_disagreement_score":0.0006577502,"about_ca_system_score_codex":0.0002645976,"about_ca_system_score_gemma":0.00014090714,"threshold_uncertainty_score":0.002200365},"labels":[],"label_agreement":null},{"id":"W2045521299","doi":"10.1016/j.bmcl.2009.11.057","title":"Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"PI3K/AKT/mTOR pathway; Chemistry; Kinase; Protein kinase B; Phosphorylation; Dual (grammatical number); Cell growth; Cell biology; Biochemistry; Signal transduction; Biology","score_opus":0.009296777605049836,"score_gpt":0.24140116953338817,"score_spread":0.23210439192833832,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2045521299","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.77015156,0.11432595,0.022550153,0.0022927944,0.0017348885,0.0007083332,0.0018351692,0.0012367773,0.08516422],"genre_scores_gemma":[0.9515781,0.02345925,0.0090290345,0.00043526295,0.00016851853,0.00015286461,0.0006186868,0.000045850764,0.01451242],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989474,0.000019928704,0.000008740231,0.00001881999,0.0000202949,0.000037574726],"domain_scores_gemma":[0.9999707,0.0000041368285,0.000006720008,0.0000034451489,0.0000046059436,0.0000104530245],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026712703,0.00059173146,0.00051174813,0.00044493526,0.0003595868,0.00059472787,0.00062061095,0.00041173992,0.0024338008],"category_scores_gemma":[0.00013693943,0.00026220432,0.00020854021,0.00039241774,0.00021048711,0.0004356266,0.00031919935,0.0006796427,0.00069628505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0025205873,0.00066291215,0.0007700502,0.001219834,0.00008339562,0.0015470743,0.00030798247,0.0053361137,0.71938586,0.020442436,0.010678834,0.237045],"study_design_scores_gemma":[0.0020417476,0.008874273,0.0041049058,0.00014323326,0.00030470063,0.003354708,0.00010871846,0.01156206,0.71983016,0.0025900798,0.2469512,0.00013412793],"about_ca_topic_score_codex":0.0010258089,"about_ca_topic_score_gemma":0.0035214436,"teacher_disagreement_score":0.0024338008,"about_ca_system_score_codex":0.0009771084,"about_ca_system_score_gemma":0.00033387062,"threshold_uncertainty_score":0.008141875},"labels":[],"label_agreement":null},{"id":"W2045972594","doi":"10.1016/j.bmcl.2014.05.090","title":"Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Christie (Canada)","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Science Foundation","keywords":"Chemistry; Alkyl; Stereochemistry; Double bond; Base (topology); Receptor; Chemical synthesis; Side chain; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry","score_opus":0.009484103499594195,"score_gpt":0.2191721614488321,"score_spread":0.2096880579492379,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2045972594","genre_codex":"empirical","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9362411,0.0072693173,0.033364575,0.00041122927,0.0001901689,0.00033728452,0.00069803844,0.00029027034,0.021197902],"genre_scores_gemma":[0.9826063,0.00419818,0.0074715847,0.00011641426,0.00003049652,0.00007423101,0.0003078404,0.000047036512,0.005148053],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983764,0.000036314283,0.000018124783,0.000030655174,0.000029621338,0.00004756609],"domain_scores_gemma":[0.9999138,0.000018135379,0.000019858053,0.000015191873,0.000014447717,0.0000184775],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005304519,0.00039415815,0.00022865052,0.00034260098,0.00024867686,0.00027125288,0.0004549495,0.00047055428,0.0024827467],"category_scores_gemma":[0.00042417904,0.00024433367,0.0003229244,0.00025159807,0.0003035236,0.000545613,0.00043293717,0.00080488273,0.0008141889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080858363,0.00021906025,0.00023021578,0.00027820378,0.00005217602,0.00056463445,0.0002002793,0.0010297473,0.969396,0.003397058,0.00037364147,0.023450267],"study_design_scores_gemma":[0.00006853032,0.0008711809,0.00026696958,0.000015368681,0.000025766552,0.00028419224,0.00002567212,0.000427524,0.9900918,0.0002002907,0.0077045495,0.000018079136],"about_ca_topic_score_codex":0.00030975707,"about_ca_topic_score_gemma":0.0007159536,"teacher_disagreement_score":0.0024827467,"about_ca_system_score_codex":0.00023001671,"about_ca_system_score_gemma":0.00026964827,"threshold_uncertainty_score":0.008305609},"labels":[],"label_agreement":null},{"id":"W2046960502","doi":"10.1016/s0960-894x(03)00553-5","title":"Synthesis of pyrimidinopyridine–triazene conjugates targeted to abl tyrosine kinase","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"","keywords":"Triazene; Chemistry; Moiety; ABL; Tyrosine kinase; Conjugate; Conjugated system; Stereochemistry; Tyrosine; Biochemistry; Tyrosine-kinase inhibitor; Organic chemistry; Receptor; Internal medicine","score_opus":0.012175608539639275,"score_gpt":0.23722173036004804,"score_spread":0.22504612182040876,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2046960502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9257178,0.004116341,0.04104199,0.0004965674,0.00028091052,0.0004775096,0.00068623415,0.0006010478,0.026581515],"genre_scores_gemma":[0.9813044,0.0014738041,0.009349269,0.000089705565,0.00002227019,0.00012831592,0.00032280653,0.000054472777,0.0072550587],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998803,0.000021469972,0.000011895875,0.000024222403,0.000023966566,0.000038102466],"domain_scores_gemma":[0.99992085,0.000014427164,0.000026687228,0.000010920595,0.000010731302,0.000016351689],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021321786,0.00039727197,0.0003401019,0.00022488204,0.00024130274,0.00026938462,0.00035984226,0.00040419336,0.0027687438],"category_scores_gemma":[0.00017582702,0.00027858658,0.00021191868,0.0002692303,0.00014974356,0.00035808043,0.00026959556,0.0005468219,0.0006549228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032943746,0.0001095444,0.000113321,0.00019960394,0.000022201873,0.00038613394,0.00015395011,0.0012656798,0.9815454,0.0021243768,0.0004390397,0.013311372],"study_design_scores_gemma":[0.00006723813,0.00047052297,0.00023001723,0.0000061313535,0.000017106418,0.00021593038,0.000010149764,0.0007582089,0.9913395,0.000098612305,0.0067783357,0.0000082226115],"about_ca_topic_score_codex":0.00024009032,"about_ca_topic_score_gemma":0.00045900085,"teacher_disagreement_score":0.0027687438,"about_ca_system_score_codex":0.00040742144,"about_ca_system_score_gemma":0.0002780148,"threshold_uncertainty_score":0.009262383},"labels":[],"label_agreement":null},{"id":"W2047045426","doi":"10.1016/j.bmcl.2009.09.068","title":"Delta agonist hydroxy bioisosteres: The discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Agonist; Benzamide; Piperidine; Amide; Stereochemistry; Metabolic stability; Carboxamide; Selectivity; Delta; δ-opioid receptor; In vitro; Receptor; Biochemistry","score_opus":0.01684009198512015,"score_gpt":0.22786032778432808,"score_spread":0.21102023579920792,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2047045426","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9646521,0.0075004646,0.018577367,0.00036064684,0.00012221192,0.00015811897,0.0006687616,0.00020491894,0.0077553634],"genre_scores_gemma":[0.9812227,0.004900707,0.007664277,0.00014538057,0.000047667338,0.00007934218,0.0006517668,0.00003710248,0.005250999],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999099,0.000013415554,0.000010678709,0.00001804403,0.000016666812,0.000031232994],"domain_scores_gemma":[0.9998926,0.00001614933,0.000024003732,0.0000128026495,0.000024165089,0.000030279649],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030853774,0.00043871338,0.00030246977,0.00021556782,0.00014026956,0.00032034592,0.00050338503,0.00026385317,0.0018053752],"category_scores_gemma":[0.00027686628,0.00020865916,0.00020431298,0.00012512556,0.00020882653,0.00032292318,0.0002956483,0.0004940748,0.00065726764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005372248,0.00012476808,0.00033114853,0.00015471128,0.000021409664,0.00039335253,0.00009056734,0.0006857541,0.9696667,0.0013554425,0.0003126709,0.02632626],"study_design_scores_gemma":[0.000228283,0.0032933627,0.001252833,0.000026064954,0.000080744656,0.00083505514,0.000055012162,0.001174493,0.9785194,0.0002505831,0.014256203,0.000027966124],"about_ca_topic_score_codex":0.0005863201,"about_ca_topic_score_gemma":0.0012296331,"teacher_disagreement_score":0.0018053752,"about_ca_system_score_codex":0.00034898566,"about_ca_system_score_gemma":0.0003449543,"threshold_uncertainty_score":0.00603956},"labels":[],"label_agreement":null},{"id":"W2047351554","doi":"10.1016/s0960-894x(03)00512-2","title":"Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microwave-Assisted Synthesis and Applications","field":"Chemistry","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Glycopeptide; Benzoxazole; Antibiotics; Glycopeptide antibiotic; Stereochemistry; Antibacterial agent; Chemical synthesis; Combinatorial chemistry; Vancomycin; In vitro; Organic chemistry; Biochemistry; Bacteria; Staphylococcus aureus","score_opus":0.017456849787718963,"score_gpt":0.22868514436300943,"score_spread":0.21122829457529047,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2047351554","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9852881,0.008281032,0.0031840869,0.000143644,0.000057766025,0.000062085,0.0003223089,0.000041947358,0.0026189724],"genre_scores_gemma":[0.9905939,0.0040397337,0.002306536,0.000040319206,0.00002434686,0.00002798981,0.0003665648,0.000011801632,0.00258869],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991345,0.000017856235,0.000008341519,0.00001145469,0.00002176554,0.000027050193],"domain_scores_gemma":[0.99993634,0.000007398236,0.0000223724,0.000005284559,0.0000088037905,0.00001975947],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011647056,0.0002995789,0.00038094164,0.00012946715,0.00013688563,0.00024830867,0.00032041097,0.00021017528,0.0008542695],"category_scores_gemma":[0.00012558217,0.00013729114,0.00017249095,0.00015816391,0.00016827238,0.00019310118,0.00013777662,0.0003610706,0.00025068436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027185772,0.00004372907,0.00011844992,0.0000762546,0.000013040474,0.00012896731,0.000020603386,0.00037222318,0.9952878,0.00020183898,0.000066304616,0.0033989123],"study_design_scores_gemma":[0.0001001804,0.00089579774,0.0017860604,0.000006879329,0.000025619573,0.00024448338,0.000010594877,0.00053675787,0.992132,0.00003325676,0.0042181425,0.000010153955],"about_ca_topic_score_codex":0.00059039576,"about_ca_topic_score_gemma":0.0010219481,"teacher_disagreement_score":0.0008542695,"about_ca_system_score_codex":0.00032044185,"about_ca_system_score_gemma":0.00016471514,"threshold_uncertainty_score":0.002857864},"labels":[],"label_agreement":null},{"id":"W2048036402","doi":"10.1016/j.bmcl.2010.04.143","title":"Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Neuropeptide; Neuropeptide Y receptor; Receptor; Stereochemistry; Chemical synthesis; Pharmacology; Biochemistry; In vitro","score_opus":0.04221458858001452,"score_gpt":0.290597862141865,"score_spread":0.24838327356185047,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2048036402","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9485768,0.018336717,0.016155595,0.0006346237,0.0003306103,0.0011255132,0.0018258278,0.00039530132,0.012618937],"genre_scores_gemma":[0.94622326,0.021786181,0.0143128,0.00063870026,0.0001186032,0.0005116553,0.0027389275,0.000056562913,0.013613358],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989736,0.000015713458,0.000010481615,0.000018701581,0.000020823543,0.000036890327],"domain_scores_gemma":[0.9999498,0.0000053524336,0.000009688955,0.000004055299,0.000009828554,0.00002131917],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023530718,0.000538828,0.00066066085,0.00038261418,0.000294578,0.00037441636,0.00060666574,0.00031041156,0.0024812366],"category_scores_gemma":[0.0001855434,0.000217,0.00033595445,0.00022290974,0.00019876877,0.0003147091,0.0002606383,0.0005509933,0.0006822636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009649759,0.00053838553,0.00026440882,0.0003445569,0.00008684446,0.00045608755,0.00011041178,0.0014750155,0.9516667,0.0010740118,0.0015870036,0.04143148],"study_design_scores_gemma":[0.0022563771,0.02856692,0.003929096,0.00011713893,0.00042959786,0.0025852632,0.00014498243,0.0047961934,0.88199955,0.0006270503,0.074434854,0.000113036884],"about_ca_topic_score_codex":0.00083025586,"about_ca_topic_score_gemma":0.002362383,"teacher_disagreement_score":0.0024812366,"about_ca_system_score_codex":0.00028203864,"about_ca_system_score_gemma":0.0004797527,"threshold_uncertainty_score":0.008300543},"labels":[],"label_agreement":null},{"id":"W2048231889","doi":"10.1016/s0960-894x(03)00194-x","title":"New scaffolds in the development of Mu opioid-receptor ligands","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Pyrrolidine; Dipeptide; Stereochemistry; Tetrahydroisoquinoline; Ring (chemistry); Alkylation; Affinities; Carboxamide; Hydrogen bond; Combinatorial chemistry; Molecule; Peptide; Biochemistry; Organic chemistry","score_opus":0.023147858196218805,"score_gpt":0.24082447196574533,"score_spread":0.21767661376952652,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2048231889","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7738065,0.074083604,0.10309739,0.0021797423,0.00059544336,0.00037446016,0.0012407941,0.0009892152,0.04363289],"genre_scores_gemma":[0.9083868,0.035622057,0.04227255,0.00046291942,0.00013670092,0.0002652312,0.0007410222,0.00008650907,0.012026218],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998872,0.000024450157,0.000008684597,0.000018097751,0.000024920222,0.000036638772],"domain_scores_gemma":[0.99990726,0.000024702651,0.000022995995,0.000006492099,0.000013656704,0.000024859812],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003906964,0.00044601638,0.00037254533,0.00041689293,0.00022844701,0.000659912,0.00050890684,0.00045038684,0.0024780403],"category_scores_gemma":[0.00025540692,0.00025398756,0.00023178806,0.00035643575,0.00025383188,0.0009067727,0.00042819415,0.00058814447,0.00090511184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013788891,0.00044113788,0.0005276401,0.0011884109,0.00005459596,0.0012413595,0.00045499305,0.0076121315,0.7760511,0.036474686,0.0026722844,0.17190275],"study_design_scores_gemma":[0.0004429522,0.0038680127,0.0013845051,0.00020866592,0.00012859936,0.0010870064,0.00025351482,0.008487044,0.8562678,0.009468863,0.11831396,0.00008907546],"about_ca_topic_score_codex":0.0002663933,"about_ca_topic_score_gemma":0.0005928526,"teacher_disagreement_score":0.0024780403,"about_ca_system_score_codex":0.00040698046,"about_ca_system_score_gemma":0.00031618963,"threshold_uncertainty_score":0.008289874},"labels":[],"label_agreement":null},{"id":"W2048360841","doi":"10.1016/j.bmcl.2010.04.065","title":"Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Benzoic acid; Antagonist; Indole test; Potency; In vivo; Stereochemistry; Derivative (finance); Chemical synthesis; Trifluoromethyl; NK1 receptor antagonist; Pharmacology; Pharmacokinetics; In vitro; Biochemistry; Receptor; Organic chemistry; Medicine; Neuropeptide","score_opus":0.004648992860490745,"score_gpt":0.21611761223195347,"score_spread":0.21146861937146272,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2048360841","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93812364,0.020322006,0.016392462,0.0017616147,0.0003487926,0.00053201837,0.0014925294,0.00037065166,0.020656256],"genre_scores_gemma":[0.97171855,0.009355152,0.006915888,0.00044857216,0.00014600331,0.00016150062,0.0010893934,0.000023104205,0.010141841],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999212,0.000014536636,0.000004003221,0.000010510284,0.000019137993,0.000030482084],"domain_scores_gemma":[0.9999684,0.0000042364236,0.000008385736,0.0000025253478,0.0000062779673,0.000010154592],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016528579,0.0004054545,0.0003737782,0.00027675016,0.00017038372,0.00021323004,0.0004031186,0.00039224423,0.0019372755],"category_scores_gemma":[0.00015294178,0.00017756507,0.00022380547,0.00011955125,0.00016747748,0.00018248403,0.00018777809,0.0005266344,0.0008753551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046924665,0.00015010244,0.00018224702,0.00020614124,0.000022004464,0.00047850967,0.000034337023,0.00049905817,0.9767298,0.00070612633,0.0006615861,0.019860838],"study_design_scores_gemma":[0.00062124204,0.003958052,0.003203289,0.000031221705,0.00009659869,0.0016337886,0.00002369439,0.0017587584,0.96262866,0.00021682309,0.025802372,0.000025363563],"about_ca_topic_score_codex":0.0006495991,"about_ca_topic_score_gemma":0.0015358273,"teacher_disagreement_score":0.0019372755,"about_ca_system_score_codex":0.00030202945,"about_ca_system_score_gemma":0.00038173108,"threshold_uncertainty_score":0.006480813},"labels":[],"label_agreement":null},{"id":"W2048788422","doi":"10.1016/s0960-894x(02)00151-8","title":"Synthesis of a molecular mimic of the Glc1Man9 oligoside as potential inhibitor of calnexin binding to ΔF508 CFTR protein","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Calnexin; Endoplasmic reticulum; Cystic fibrosis; ΔF508; Cystic fibrosis transmembrane conductance regulator; Glycoprotein; Binding protein; Biochemistry; Cell biology; Calreticulin; Gene; Biology","score_opus":0.008099040295895957,"score_gpt":0.23571080026789906,"score_spread":0.2276117599720031,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2048788422","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9870006,0.0006939129,0.008037702,0.00018176895,0.00007885686,0.00019849413,0.00041363848,0.000094216346,0.0033007872],"genre_scores_gemma":[0.98304623,0.00059165177,0.011585787,0.00008156611,0.0000142234085,0.000088581066,0.00076867564,0.000022750324,0.0038005763],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993336,0.000012971028,0.0000068740487,0.000012491591,0.000012407473,0.000021844704],"domain_scores_gemma":[0.99992776,0.000007992988,0.000018893734,0.000007193253,0.000009805662,0.000028294826],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012909228,0.0003565185,0.00025792723,0.000113108974,0.00016702917,0.00018389923,0.0003419275,0.00034947792,0.0015373592],"category_scores_gemma":[0.0001405057,0.00014083796,0.00026791033,0.00013941442,0.00011430808,0.00016376206,0.00016725356,0.00049384736,0.00046577948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001684799,0.000042506923,0.000057779594,0.000047415284,0.000009296189,0.00019373286,0.000019334664,0.0005825921,0.99683505,0.00034710695,0.000055614335,0.0016410572],"study_design_scores_gemma":[0.000032587788,0.00047131107,0.00027596994,0.000003791852,0.000014378234,0.00014250493,0.000008658504,0.0010394427,0.99560237,0.000039104707,0.002363102,0.0000066863463],"about_ca_topic_score_codex":0.0007556893,"about_ca_topic_score_gemma":0.0006912496,"teacher_disagreement_score":0.0015373592,"about_ca_system_score_codex":0.00031301606,"about_ca_system_score_gemma":0.0003710551,"threshold_uncertainty_score":0.005142987},"labels":[],"label_agreement":null},{"id":"W2049116850","doi":"10.1016/j.bmcl.2007.05.024","title":"Primary amides as selective inhibitors of cathepsin K","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Carboxamide; Primary (astronomy); Stereochemistry; Chemical synthesis; Enzyme inhibitor; Biochemistry; In vitro","score_opus":0.004101317911104719,"score_gpt":0.21837245713873663,"score_spread":0.2142711392276319,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049116850","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9398088,0.02425059,0.008094324,0.0007340708,0.00066277746,0.00033747117,0.0009913979,0.0005222088,0.024598366],"genre_scores_gemma":[0.9752637,0.012900345,0.0022454143,0.0002625814,0.00009750923,0.000089814464,0.0005580402,0.00003903497,0.008543359],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986446,0.0000263208,0.0000102964095,0.000017150516,0.000028176415,0.000053625965],"domain_scores_gemma":[0.99992144,0.00001809894,0.0000146467955,0.000007912936,0.000010751047,0.000027094198],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036723336,0.00057939684,0.0004411219,0.00031036837,0.00017227842,0.00032085177,0.00043175844,0.00038671502,0.0029492783],"category_scores_gemma":[0.00021322517,0.00032785925,0.0002798057,0.00018740943,0.00024910163,0.00036131887,0.00028798718,0.00082682,0.0007562808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002436417,0.00030385904,0.00024812695,0.0004153134,0.00006101705,0.00071404665,0.00013678847,0.001589677,0.9626798,0.0017776503,0.0019577346,0.027679646],"study_design_scores_gemma":[0.0012620778,0.0061755124,0.0017792786,0.00004142288,0.00009965208,0.0014767369,0.0000527635,0.0018262416,0.96318454,0.0005332173,0.023522686,0.000045863067],"about_ca_topic_score_codex":0.00044810944,"about_ca_topic_score_gemma":0.0010797004,"teacher_disagreement_score":0.0029492783,"about_ca_system_score_codex":0.0003192115,"about_ca_system_score_gemma":0.0002367718,"threshold_uncertainty_score":0.009866297},"labels":[],"label_agreement":null},{"id":"W2049210618","doi":"10.1016/j.bmcl.2005.03.108","title":"A micromethod for the stereochemical analysis of fatty acid desaturase-mediated sulfoxidation reactions","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Molecular spectroscopy and chirality","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Canada; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Reagent; Fatty acid; Analyte; Organic chemistry; Stereochemistry; Chromatography; Biochemistry","score_opus":0.01414249710017801,"score_gpt":0.26991230491635515,"score_spread":0.25576980781617714,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049210618","genre_codex":"methods","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":"methods","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.13339803,0.0017857954,0.8543927,0.00018793975,0.00026689598,0.0006586389,0.0023467895,0.0023039675,0.0046592853],"genre_scores_gemma":[0.31182486,0.0023555502,0.6724372,0.00020176834,0.000059792677,0.0016964539,0.0021338165,0.00018943413,0.009101158],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999286,0.000116528354,0.000059890142,0.00018900246,0.00026140333,0.00008719367],"domain_scores_gemma":[0.9994537,0.00012343476,0.000059792896,0.00015206455,0.00015261852,0.000058335205],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009927636,0.00058867695,0.00044827713,0.00097278634,0.0006267596,0.00036279546,0.0007365591,0.00062252383,0.0019192594],"category_scores_gemma":[0.00066067977,0.00038543495,0.00033708676,0.00055327703,0.00038588533,0.00037883286,0.00056511164,0.0010206559,0.0010441566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007029607,0.00005136828,0.00044139798,0.00006830777,0.0000112570915,0.000029781864,0.000022981423,0.00013497505,0.97341835,0.0012215263,0.0002593594,0.024270399],"study_design_scores_gemma":[0.000013941725,0.00021116495,0.00073282403,0.000006721639,0.000013787739,0.00015425321,0.000016066826,0.0017187608,0.99230754,0.00037265793,0.00443894,0.000013287654],"about_ca_topic_score_codex":0.0008767687,"about_ca_topic_score_gemma":0.002069937,"teacher_disagreement_score":0.0019192594,"about_ca_system_score_codex":0.00045898228,"about_ca_system_score_gemma":0.0013759892,"threshold_uncertainty_score":0.0064206123},"labels":[],"label_agreement":null},{"id":"W2049300936","doi":"10.1016/j.bmcl.2004.10.040","title":"2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Ryerson University; University of Minnesota; Eli Lilly and Company","keywords":"Chemistry; Steric effects; Methylene; Stereochemistry; Metabotropic glutamate receptor; Ligand (biochemistry); Ethylene; Amino acid; Metabotropic receptor; Receptor; Glutamate receptor; Medicinal chemistry; Organic chemistry; Biochemistry; Catalysis","score_opus":0.02005490888989953,"score_gpt":0.25810578088391267,"score_spread":0.23805087199401315,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049300936","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99198407,0.0011908149,0.0016146858,0.00012170812,0.00012234083,0.000040646926,0.00016714005,0.00004550933,0.0047129523],"genre_scores_gemma":[0.9940599,0.0007534915,0.0018606733,0.000120172306,0.000021875738,0.0000345765,0.00025253813,0.000014615083,0.0028820664],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987066,0.0000410926,0.000009915705,0.000017559882,0.000020580825,0.000040210918],"domain_scores_gemma":[0.99990153,0.000017744713,0.00002474646,0.0000140217435,0.000009476608,0.00003230568],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018671525,0.00021601345,0.0003095011,0.00012267762,0.00015599068,0.00019013936,0.00055264274,0.00044504038,0.0026520276],"category_scores_gemma":[0.00023027541,0.00012952716,0.00015519191,0.00016551653,0.00020820207,0.00032255304,0.0002002056,0.00051842304,0.0004507618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019528627,0.00009328491,0.000102427926,0.00008718093,0.0000131927145,0.0002654881,0.00004653127,0.0006038342,0.9919036,0.0011366011,0.00011516644,0.0036796667],"study_design_scores_gemma":[0.0004987425,0.0033259713,0.0014416523,0.000015871423,0.000030070938,0.0005200087,0.000047763962,0.00192376,0.9844483,0.00023126426,0.0074916906,0.000024967776],"about_ca_topic_score_codex":0.00044422937,"about_ca_topic_score_gemma":0.0006493856,"teacher_disagreement_score":0.0026520276,"about_ca_system_score_codex":0.00026033507,"about_ca_system_score_gemma":0.00022470801,"threshold_uncertainty_score":0.008871913},"labels":[],"label_agreement":null},{"id":"W2049382754","doi":"10.1016/j.bmcl.2010.09.129","title":"Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Microsome; Enzyme; Prostaglandin; High-throughput screening; ATP synthase; Enzyme inhibitor; Potency; Pharmacology; Prostaglandin E; Biochemistry; Prostaglandin E2; In vitro; Internal medicine","score_opus":0.004231931028297222,"score_gpt":0.2215163245732647,"score_spread":0.21728439354496748,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049382754","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9515989,0.027124701,0.0049072243,0.0006336826,0.00035300656,0.00013328905,0.0006609623,0.00047387564,0.014114367],"genre_scores_gemma":[0.9803538,0.01029032,0.0014556064,0.00011837699,0.000060899936,0.00004519682,0.00067687436,0.00002228546,0.0069766506],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998543,0.000031517662,0.000011446642,0.000012706725,0.000035707857,0.00005427881],"domain_scores_gemma":[0.99994695,0.000011558623,0.000010796974,0.0000050929407,0.000010084283,0.00001539502],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024541907,0.00033819166,0.00037360165,0.00039710352,0.000247506,0.0003054086,0.00043668764,0.00029462014,0.002165318],"category_scores_gemma":[0.00020635438,0.00015779695,0.0001682326,0.00037766725,0.00013267605,0.00023722893,0.00024563423,0.0006682685,0.0004937803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002076574,0.0003144965,0.0004303136,0.00025446582,0.000042716507,0.0002989395,0.00009941153,0.00064254575,0.9648263,0.0016364515,0.0016056178,0.027772151],"study_design_scores_gemma":[0.00072402554,0.0041942447,0.005177505,0.00003468968,0.00014210552,0.0007770928,0.00007298221,0.0031244543,0.9574952,0.00029770736,0.027919972,0.000040036248],"about_ca_topic_score_codex":0.0017145323,"about_ca_topic_score_gemma":0.0050924905,"teacher_disagreement_score":0.002165318,"about_ca_system_score_codex":0.0003606277,"about_ca_system_score_gemma":0.0002797257,"threshold_uncertainty_score":0.007243693},"labels":[],"label_agreement":null},{"id":"W2049403290","doi":"10.1016/s0960-894x(00)00021-4","title":"Design and synthesis of mimics of S-adenosyl-l-homocysteine as potential inhibitors of erythromycin methyltransferases","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Methyltransferase; Erythromycin; Stereochemistry; Homocysteine; Enzyme inhibitor; Enzyme; Biochemistry; Pharmacology; Combinatorial chemistry; Antibiotics; Methylation","score_opus":0.0059245827218163735,"score_gpt":0.22042024815306518,"score_spread":0.21449566543124882,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049403290","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94948727,0.0059234975,0.033441085,0.0003812802,0.0001962011,0.000533825,0.0005712036,0.00046559583,0.008999981],"genre_scores_gemma":[0.9784919,0.002210388,0.015046219,0.00007075308,0.000024011784,0.00014060104,0.00038409498,0.000032691296,0.0035993026],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998068,0.000054348075,0.00002252608,0.000030045989,0.000046484947,0.000039771305],"domain_scores_gemma":[0.99984825,0.000027742093,0.000039433042,0.00001912025,0.000022964616,0.000042448053],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003476882,0.00039183142,0.00047191783,0.0001996587,0.00022210611,0.00044634982,0.00062900456,0.0005510151,0.0011773243],"category_scores_gemma":[0.00050377933,0.00030760167,0.0003248667,0.00017266982,0.00021314266,0.0002867141,0.0002876798,0.00050567416,0.0005045593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005774046,0.00011866988,0.00022188622,0.0002229589,0.000046131347,0.00044435836,0.00012551105,0.00497406,0.97796714,0.0033444935,0.00033564804,0.0116217],"study_design_scores_gemma":[0.0000701302,0.00067860435,0.00019920093,0.000009422531,0.000033316115,0.00020413694,0.000017498323,0.0029868744,0.987528,0.00012889192,0.008129468,0.000014421758],"about_ca_topic_score_codex":0.000468044,"about_ca_topic_score_gemma":0.0007917352,"teacher_disagreement_score":0.0011773243,"about_ca_system_score_codex":0.0006470199,"about_ca_system_score_gemma":0.000346178,"threshold_uncertainty_score":0.0046945214},"labels":[],"label_agreement":null},{"id":"W2049525497","doi":"10.1016/s0960-894x(03)00128-8","title":"Novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; In vivo; Aryl; Pharmacology; In vitro; Moiety; Stereochemistry; Glucocorticoid receptor; Steroid; Potency; Receptor; Biochemistry; Alkyl; Hormone; Organic chemistry","score_opus":0.004586937308625703,"score_gpt":0.2111190905352614,"score_spread":0.2065321532266357,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049525497","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9499094,0.023793679,0.008967348,0.0006856666,0.00030807365,0.00015681353,0.0006080802,0.00036287348,0.015208111],"genre_scores_gemma":[0.96703666,0.014803929,0.0035687096,0.0003029233,0.000120195706,0.00008952978,0.000592293,0.00003238382,0.013453286],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999312,0.00001681525,0.000004491233,0.000008998134,0.000015417141,0.00002300528],"domain_scores_gemma":[0.99996376,0.000005226015,0.0000106980715,0.0000037782052,0.00000501907,0.000011484428],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016786357,0.00040351364,0.00029515233,0.00023345952,0.00015197026,0.00021084546,0.00032779112,0.00025822668,0.002413565],"category_scores_gemma":[0.000112222435,0.00018006835,0.00017505336,0.00018896873,0.00025068675,0.00019573049,0.00021308454,0.0004078403,0.0006603896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000658748,0.00014202099,0.00031866593,0.00025287815,0.000020054576,0.00058423093,0.00015284597,0.0008136302,0.9740068,0.0017808523,0.00088892994,0.020380396],"study_design_scores_gemma":[0.00077938766,0.0075719645,0.0072183525,0.0000559387,0.00012240319,0.00283956,0.00016917125,0.0028283722,0.9250994,0.0007272708,0.05253616,0.00005207208],"about_ca_topic_score_codex":0.00039853627,"about_ca_topic_score_gemma":0.0021455563,"teacher_disagreement_score":0.002413565,"about_ca_system_score_codex":0.00020223796,"about_ca_system_score_gemma":0.00018954926,"threshold_uncertainty_score":0.008074224},"labels":[],"label_agreement":null},{"id":"W2049539663","doi":"10.1016/j.bmcl.2011.09.089","title":"Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Phosphoramidate; Prodrug; Nucleoside; Chemistry; Cytotoxicity; Stereochemistry; Nucleoside analogue; In vitro; Chemical synthesis; Biochemistry","score_opus":0.024048436268340346,"score_gpt":0.24334430083744724,"score_spread":0.21929586456910688,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049539663","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98122644,0.0047042686,0.0053626527,0.00010828595,0.00005767616,0.00007827286,0.0004209672,0.00011707777,0.007924369],"genre_scores_gemma":[0.9900535,0.0016987219,0.0036965383,0.00004446012,0.0000160007,0.00004820337,0.0004742101,0.000021242591,0.0039471425],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999057,0.000027768225,0.000011454568,0.000016059463,0.000020030997,0.000018960336],"domain_scores_gemma":[0.99993217,0.000020158795,0.000013100439,0.000012091143,0.000008570806,0.000013916687],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021676198,0.0002793768,0.00023188333,0.00021010535,0.00015542575,0.0002218022,0.00028534213,0.00027510646,0.0014677494],"category_scores_gemma":[0.00021082113,0.00022795613,0.00018640928,0.00013287028,0.00014504165,0.00021931884,0.00014085502,0.0002762448,0.00040621395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00057040696,0.000067493915,0.00015075985,0.0001128716,0.000012765127,0.00019479453,0.000066652,0.0010736407,0.98326033,0.00092611887,0.00014272853,0.01342136],"study_design_scores_gemma":[0.000051726252,0.0008644729,0.0004580634,0.000006089848,0.000018374427,0.00019543806,0.00000767771,0.0006244583,0.99465466,0.00008118001,0.003031622,0.000006269962],"about_ca_topic_score_codex":0.00042657752,"about_ca_topic_score_gemma":0.00048649858,"teacher_disagreement_score":0.0014677494,"about_ca_system_score_codex":0.00018091197,"about_ca_system_score_gemma":0.0002335746,"threshold_uncertainty_score":0.004910052},"labels":[],"label_agreement":null},{"id":"W2049633933","doi":"10.1016/j.bmcl.2008.09.009","title":"Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Stereochemistry; Identification (biology); Structure–activity relationship; Series (stratigraphy); Combinatorial chemistry; In vitro; Biochemistry","score_opus":0.007868477577463357,"score_gpt":0.20041239276442888,"score_spread":0.1925439151869655,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049633933","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9893985,0.005381798,0.0018972621,0.000111227564,0.00002862344,0.00013447515,0.0004371644,0.00006807263,0.0025429258],"genre_scores_gemma":[0.9893142,0.0047187787,0.0032901273,0.00006151378,0.000015863707,0.00005311571,0.00080110406,0.00002026226,0.0017250627],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988484,0.00001955247,0.000011559987,0.00002080014,0.0000339821,0.000029302928],"domain_scores_gemma":[0.9999249,0.00001049774,0.000018612347,0.0000055709334,0.000015605829,0.000024847071],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024221529,0.00049151946,0.00050847896,0.00038022603,0.00017735727,0.0002992509,0.00042190193,0.00022320046,0.0014182945],"category_scores_gemma":[0.00018172435,0.00018943797,0.00032065914,0.00031172595,0.00017459542,0.00021792475,0.00016389156,0.00046999662,0.0003157483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000853861,0.00086796103,0.00050302525,0.00014742804,0.0000572213,0.00016234028,0.000037156784,0.0027176773,0.9754498,0.0002744172,0.00026400387,0.018665092],"study_design_scores_gemma":[0.0007891918,0.011041338,0.005556576,0.000026515145,0.0002738323,0.0006921192,0.000045327364,0.0047148825,0.96939105,0.00008345545,0.007351081,0.000034702694],"about_ca_topic_score_codex":0.0013131866,"about_ca_topic_score_gemma":0.0040130005,"teacher_disagreement_score":0.0014182945,"about_ca_system_score_codex":0.00034622225,"about_ca_system_score_gemma":0.00042789572,"threshold_uncertainty_score":0.004744649},"labels":[],"label_agreement":null},{"id":"W2049715176","doi":"10.1016/s0960-894x(02)00349-9","title":"Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Moiety; Catechol; Covalent bond; Reactive intermediate; Covalent binding; Metabolic stability; Stereochemistry; Combinatorial chemistry; Phosphodiesterase; Enzyme; Biochemistry; Organic chemistry; In vitro; Catalysis","score_opus":0.016212134412287443,"score_gpt":0.22162427743579163,"score_spread":0.2054121430235042,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049715176","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98999643,0.0011208465,0.0074150832,0.00011541866,0.000033468838,0.00004329822,0.00011196067,0.00010153676,0.0010619058],"genre_scores_gemma":[0.99710613,0.000272169,0.0019298855,0.000029798688,0.000006710849,0.000010337068,0.00008800276,0.000015549078,0.00054151384],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998553,0.00002960322,0.000013463421,0.00002636782,0.000029211995,0.000046001467],"domain_scores_gemma":[0.99980253,0.000035511694,0.000072731964,0.000028237804,0.000027121298,0.00003385965],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003109311,0.00036383886,0.000287312,0.00014551957,0.00016964095,0.0003360914,0.00046521396,0.00045034883,0.00085189345],"category_scores_gemma":[0.00033166163,0.0001906184,0.00030399536,0.00011891423,0.00017841687,0.0003610713,0.00022911862,0.00055448996,0.00020572435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004686821,0.00008912151,0.00019773658,0.000039549614,0.000023871986,0.00006912873,0.000015885284,0.000475411,0.9937826,0.00032851464,0.00006220883,0.00444734],"study_design_scores_gemma":[0.000025952675,0.00037080262,0.00020717627,0.0000015814709,0.0000172488,0.000063563355,0.000002844824,0.00059770676,0.998178,0.000021892307,0.0005089772,0.000004321376],"about_ca_topic_score_codex":0.00046318205,"about_ca_topic_score_gemma":0.00075716956,"teacher_disagreement_score":0.00085189345,"about_ca_system_score_codex":0.00025382923,"about_ca_system_score_gemma":0.00020896616,"threshold_uncertainty_score":0.0028498769},"labels":[],"label_agreement":null},{"id":"W2049877902","doi":"10.1016/j.bmcl.2014.07.034","title":"Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Bromobenzene; Intramolecular force; Heck reaction; Stereochemistry; Chemical synthesis; Ring (chemistry); Combinatorial chemistry; Organic chemistry; Palladium; In vitro; Catalysis","score_opus":0.022756321818900922,"score_gpt":0.24240766662843302,"score_spread":0.2196513448095321,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049877902","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9929804,0.002471127,0.0021845847,0.000046811176,0.000028258832,0.00004810236,0.00031492749,0.000028089291,0.001897581],"genre_scores_gemma":[0.99401456,0.0011812925,0.0027539192,0.000021533078,0.000006056643,0.00002210711,0.0004088297,0.000008220328,0.0015835126],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999324,0.000013628893,0.000008272682,0.0000135841765,0.00002135003,0.000010865113],"domain_scores_gemma":[0.9999248,0.000009248924,0.000015345515,0.000008088555,0.000018627119,0.00002384882],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015397866,0.00020412411,0.00015732732,0.0001044802,0.00009543866,0.0001514726,0.00022147635,0.00021039101,0.00063039036],"category_scores_gemma":[0.0001271372,0.00007901204,0.0001163903,0.0000868481,0.00014357016,0.00014006026,0.00012778964,0.0002950775,0.00018052047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014682922,0.000031738,0.00005264205,0.00003699545,0.0000046367722,0.00005165819,0.000009760692,0.00013694607,0.9982451,0.00006518665,0.000015481339,0.0012030898],"study_design_scores_gemma":[0.000020988045,0.0006754895,0.0005297025,0.0000025302595,0.00001560775,0.00012846722,0.000011449907,0.00027062724,0.9962955,0.000019894176,0.0020259498,0.0000038126136],"about_ca_topic_score_codex":0.00062262674,"about_ca_topic_score_gemma":0.0010951515,"teacher_disagreement_score":0.00063039036,"about_ca_system_score_codex":0.0001785045,"about_ca_system_score_gemma":0.00021701076,"threshold_uncertainty_score":0.0021088123},"labels":[],"label_agreement":null},{"id":"W2049901704","doi":"10.1016/j.bmcl.2010.05.084","title":"Synthesis and biological evaluation of novel biotin–iminoalditol conjugates","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Biotin; Conjugate; Chemical synthesis; Combinatorial chemistry; Biochemistry; Stereochemistry; In vitro","score_opus":0.022465527848918716,"score_gpt":0.2589732622285222,"score_spread":0.23650773437960346,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049901704","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98674935,0.0025469293,0.0076927594,0.00015639128,0.000042633987,0.00014936585,0.00024209492,0.00009028111,0.0023302198],"genre_scores_gemma":[0.99002296,0.0011420501,0.005405279,0.00003943484,0.000013218204,0.000057411566,0.00036566693,0.000020672913,0.0029332887],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981314,0.000055647648,0.000018173041,0.000028004462,0.000039300252,0.000045789442],"domain_scores_gemma":[0.99984014,0.000043962027,0.000028561983,0.000020951507,0.000030107514,0.00003612075],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046856073,0.00050130783,0.00032302077,0.00022926265,0.00023518693,0.0003150447,0.00038127392,0.0004945957,0.0011024331],"category_scores_gemma":[0.0003738341,0.00018954709,0.00019128717,0.00023161352,0.00026152522,0.00032056557,0.0002242506,0.00042188668,0.0003149498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022718786,0.000077313736,0.0000574152,0.000060040948,0.000008633006,0.000101985344,0.000038028,0.00029115772,0.9972887,0.00016619597,0.00003669512,0.001646694],"study_design_scores_gemma":[0.000015425641,0.00030243577,0.00011252686,0.0000012017382,0.000009526784,0.00006279193,0.0000070969295,0.00024355897,0.9983829,0.000014282275,0.00084563164,0.0000026106027],"about_ca_topic_score_codex":0.0007152992,"about_ca_topic_score_gemma":0.00081376155,"teacher_disagreement_score":0.0011024331,"about_ca_system_score_codex":0.00063959084,"about_ca_system_score_gemma":0.00020423254,"threshold_uncertainty_score":0.004640579},"labels":[],"label_agreement":null},{"id":"W2050395172","doi":"10.1016/j.bmcl.2009.07.007","title":"Benzo[c][2,7]naphthyridines as inhibitors of PDK-1","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Stereochemistry; Crystal structure; Potency; Crystallography; In vitro; Biochemistry","score_opus":0.05960049505898765,"score_gpt":0.3892484320361612,"score_spread":0.32964793697717354,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2050395172","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94443005,0.031068271,0.002467277,0.0005875633,0.0002966464,0.00013893239,0.0007837835,0.00035305697,0.019874413],"genre_scores_gemma":[0.9724167,0.016989315,0.0014444691,0.00014309022,0.00006838517,0.000065554355,0.00072558696,0.000033063923,0.008113888],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998914,0.00002647743,0.000008275926,0.000014146542,0.000025044359,0.000034656565],"domain_scores_gemma":[0.9999584,0.000009960459,0.000010764782,0.0000050187036,0.0000058190617,0.000010089891],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001734138,0.00024325488,0.00029883327,0.0003080322,0.00019962821,0.0002840626,0.00038152133,0.00021049775,0.0023358804],"category_scores_gemma":[0.00015916652,0.00018133508,0.0001597906,0.00026635217,0.00014461546,0.000292936,0.00021021214,0.0006581838,0.0006525192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015929368,0.00030115384,0.00046081573,0.000330081,0.00004887555,0.00022538503,0.00009930849,0.0011442667,0.9574628,0.0013850199,0.001892355,0.035057038],"study_design_scores_gemma":[0.00075452885,0.0053854757,0.011790728,0.000066826804,0.00012555828,0.0009338867,0.00007623437,0.0036002516,0.9375899,0.0003901495,0.039240204,0.000046383433],"about_ca_topic_score_codex":0.0007164447,"about_ca_topic_score_gemma":0.0037972883,"teacher_disagreement_score":0.0023358804,"about_ca_system_score_codex":0.00038398994,"about_ca_system_score_gemma":0.00017661003,"threshold_uncertainty_score":0.007814288},"labels":[],"label_agreement":null},{"id":"W2050531903","doi":"10.1016/j.bmcl.2008.10.109","title":"Synthesis of 3,6-bicyclolides: A novel class of macrolide antibiotics","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ryerson University","keywords":"Chemistry; Bicyclic molecule; Erythromycin; Antibiotics; In vivo; Oxime; Broad spectrum; Macrolide Antibiotics; Ketolide; Antibacterial agent; Chemical synthesis; In vitro; Stereochemistry; Bacteria; Microbiology; Combinatorial chemistry; Biochemistry; Biology","score_opus":0.017714680652669255,"score_gpt":0.2418264447791338,"score_spread":0.22411176412646452,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2050531903","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8521495,0.026672127,0.046711817,0.0019140267,0.001069193,0.0007667487,0.0020519102,0.0009025115,0.067762166],"genre_scores_gemma":[0.94759226,0.012884554,0.023540169,0.00040663243,0.00010959748,0.00020634364,0.00096149533,0.000080983846,0.014218085],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998903,0.00001737187,0.000011235962,0.00001972791,0.000022010447,0.00003930974],"domain_scores_gemma":[0.99995077,0.0000042244073,0.000008277182,0.000005296462,0.000007649253,0.000023897066],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014605561,0.00044232004,0.0004246892,0.0002980059,0.00026049523,0.00033194255,0.00041948954,0.00036601964,0.002234439],"category_scores_gemma":[0.0001289074,0.0001749147,0.00017012269,0.00021983932,0.0001879117,0.0003108564,0.00032772456,0.00048464438,0.0011298647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006562474,0.00026332174,0.00024174711,0.0005378904,0.000027982736,0.0008966635,0.00018466105,0.0027788125,0.9219096,0.0070986813,0.0026497995,0.06275463],"study_design_scores_gemma":[0.00024228152,0.0018597399,0.0010305693,0.000075735006,0.000045546585,0.001208705,0.000057522273,0.002102679,0.8927205,0.0010314212,0.09955965,0.00006559659],"about_ca_topic_score_codex":0.00048555763,"about_ca_topic_score_gemma":0.00097278575,"teacher_disagreement_score":0.002234439,"about_ca_system_score_codex":0.00035686107,"about_ca_system_score_gemma":0.00049239653,"threshold_uncertainty_score":0.0074748993},"labels":[],"label_agreement":null},{"id":"W2051578254","doi":"10.1016/j.bmcl.2008.03.067","title":"N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Chemistry; Stereochemistry; Pyranose; Steric effects; Anomer; Thiazole; Substrate (aquarium); Thiazoline","score_opus":0.020625442374414906,"score_gpt":0.18118508781507484,"score_spread":0.16055964544065993,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2051578254","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99623376,0.0015486872,0.00042677313,0.000045519166,0.000025186688,0.000011364478,0.00012919864,0.000029336372,0.0015503535],"genre_scores_gemma":[0.99683326,0.00090064225,0.0003945997,0.000027230284,0.000009654688,0.0000076195897,0.00017500871,0.00000767845,0.0016444084],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999118,0.000030432768,0.000007591283,0.00001005603,0.000014041892,0.000026017346],"domain_scores_gemma":[0.999887,0.00002750814,0.00002256345,0.000010832103,0.000017653225,0.000034534474],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018725135,0.00024933426,0.00021239021,0.00018672593,0.000115702554,0.00016869987,0.0003298667,0.00016362361,0.0013361113],"category_scores_gemma":[0.00027462194,0.00012248394,0.00013487208,0.00014061574,0.00020494591,0.00014213906,0.00015375712,0.00035428163,0.00022979596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024688276,0.00008394577,0.00045740616,0.00012838296,0.000024771503,0.00021522441,0.00010616225,0.00092759385,0.98925996,0.00027657245,0.00024056042,0.00581053],"study_design_scores_gemma":[0.00017963117,0.0033470555,0.0024289673,0.000012050536,0.000035180325,0.00030839682,0.000048640468,0.001820292,0.989061,0.000039484767,0.0027002597,0.000019148874],"about_ca_topic_score_codex":0.0013017284,"about_ca_topic_score_gemma":0.0012400281,"teacher_disagreement_score":0.0013361113,"about_ca_system_score_codex":0.00023308805,"about_ca_system_score_gemma":0.00016070787,"threshold_uncertainty_score":0.0044696927},"labels":[],"label_agreement":null},{"id":"W2051654691","doi":"10.1016/j.bmcl.2007.09.078","title":"Preparation of carbohydrate–oligonucleotide conjugates using the squarate spacer","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"","keywords":"Oligonucleotide; Chemistry; Conjugate; Endocytosis; Covalent bond; Reagent; Glycan; Carbohydrate; Biochemistry; Combinatorial chemistry; Deoxyribonucleotide; Stereochemistry; Receptor; Organic chemistry; DNA; Glycoprotein","score_opus":0.015510788699042637,"score_gpt":0.2698800956637719,"score_spread":0.25436930696472926,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2051654691","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9677357,0.0012250484,0.024197318,0.00020925007,0.00014364207,0.00020879657,0.00028912027,0.00019089703,0.005800245],"genre_scores_gemma":[0.97007126,0.00092782464,0.021621373,0.00013807937,0.000029782666,0.00014529088,0.00067552587,0.00006235286,0.006328331],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985087,0.00003300675,0.000016741145,0.000029412182,0.000026557354,0.00004337927],"domain_scores_gemma":[0.99987185,0.000033737477,0.000023169856,0.000018170418,0.000018204933,0.00003491924],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039012308,0.0005093837,0.0003575302,0.00018738049,0.00024526563,0.0002884106,0.0002614265,0.00041131428,0.0020209297],"category_scores_gemma":[0.00031861648,0.00026483534,0.0003023674,0.00023605996,0.00017938115,0.00028952694,0.0004285831,0.0005405144,0.00086855143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011824162,0.00002132802,0.00008142531,0.000052001193,0.000008327357,0.00006904206,0.000023207207,0.00012478494,0.9969516,0.00032680423,0.000051208608,0.0021720603],"study_design_scores_gemma":[0.000022669004,0.00022760432,0.00019131345,0.000003117531,0.000008701897,0.00006835942,0.0000049127425,0.00022172545,0.997077,0.00005021575,0.0021192115,0.000005173257],"about_ca_topic_score_codex":0.00027567547,"about_ca_topic_score_gemma":0.00072907313,"teacher_disagreement_score":0.0020209297,"about_ca_system_score_codex":0.00030204415,"about_ca_system_score_gemma":0.00030794204,"threshold_uncertainty_score":0.006760657},"labels":[],"label_agreement":null},{"id":"W2051786044","doi":"10.1016/j.bmcl.2011.07.074","title":"Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":58,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"AstraZeneca","keywords":"Chemistry; Drug; Pharmacology; Drug candidate; Toxicology; Biochemical engineering; Medicine; Engineering","score_opus":0.01802356494508827,"score_gpt":0.2739586395411226,"score_spread":0.2559350745960343,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2051786044","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.44096416,0.0015694506,0.5403213,0.0010961422,0.00010728971,0.00039091642,0.0009376847,0.0023683095,0.012244728],"genre_scores_gemma":[0.8782538,0.0010627625,0.115271606,0.00030023314,0.0000441882,0.00026554495,0.0008274893,0.00029278078,0.0036816606],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995135,0.00018247758,0.000026224436,0.000061424085,0.00016828909,0.00004817229],"domain_scores_gemma":[0.9989213,0.00044711083,0.00015663942,0.00019242206,0.0002436464,0.000039034014],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671129,0.00071920117,0.00074379536,0.0005146614,0.00030953888,0.00093259825,0.0007892539,0.00032083556,0.0034290093],"category_scores_gemma":[0.003055743,0.00022802329,0.0004910427,0.00039797626,0.00036966242,0.0008507764,0.0009240708,0.0008136565,0.00070782076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014513115,0.0008970969,0.004501636,0.0005997675,0.00016440332,0.00017583904,0.000105659135,0.12021979,0.66789633,0.01823104,0.0029271357,0.18282999],"study_design_scores_gemma":[0.00010753748,0.0010516181,0.0014811612,0.000023910792,0.00011739453,0.00013547848,0.000048038364,0.21934697,0.75923747,0.0151875205,0.0032326446,0.000030320423],"about_ca_topic_score_codex":0.00046048933,"about_ca_topic_score_gemma":0.0011031842,"teacher_disagreement_score":0.0034290093,"about_ca_system_score_codex":0.0004511528,"about_ca_system_score_gemma":0.0008005961,"threshold_uncertainty_score":0.011471152},"labels":[],"label_agreement":null},{"id":"W2051792303","doi":"10.1016/j.bmcl.2013.12.114","title":"Inhibition of glutamate racemase by substrate–product analogues","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Substrate (aquarium); Glutamate receptor; Stereochemistry; Product inhibition; Fusobacterium nucleatum; Enzyme; Non-competitive inhibition; Enantiomer; Enzyme inhibitor; Biochemistry; Bacteria; Receptor","score_opus":0.004536086327644614,"score_gpt":0.20049012436768684,"score_spread":0.19595403804004224,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2051792303","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9864607,0.0022538728,0.004581799,0.0001998199,0.00011107015,0.00012798415,0.00034223334,0.00014527643,0.005777271],"genre_scores_gemma":[0.99584275,0.0006496533,0.0016195467,0.00003315974,0.0000138690275,0.000026557002,0.00033162796,0.000017324865,0.0014654706],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99965584,0.00008607615,0.000047545564,0.000060119728,0.000052788888,0.00009766905],"domain_scores_gemma":[0.99982136,0.00005734847,0.000035337296,0.000029163904,0.00002419205,0.000032671804],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045460227,0.00062558515,0.00046016,0.00023687567,0.00018214174,0.00031960433,0.00059155526,0.0005266894,0.0021206208],"category_scores_gemma":[0.00043122703,0.00024357888,0.00036181384,0.00024426263,0.00023601472,0.00039299374,0.0003098436,0.0006476519,0.00056550204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0026788071,0.00021788769,0.00028506343,0.00015945459,0.000050730578,0.00047903624,0.000082768776,0.00090500416,0.9873268,0.0009571182,0.00030621223,0.006551063],"study_design_scores_gemma":[0.00006769698,0.0008706889,0.00028854352,0.0000034067443,0.000010103317,0.00015621165,0.000009336202,0.00055063376,0.996792,0.00004187988,0.0012031955,0.000006332777],"about_ca_topic_score_codex":0.0007170013,"about_ca_topic_score_gemma":0.00080204697,"teacher_disagreement_score":0.0021206208,"about_ca_system_score_codex":0.00039229935,"about_ca_system_score_gemma":0.00033682035,"threshold_uncertainty_score":0.007094145},"labels":[],"label_agreement":null},{"id":"W2051798718","doi":"10.1016/j.bmcl.2008.06.054","title":"Synthesis and biological evaluation of a focused library of beauveriolides","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institut national de la recherche scientifique","keywords":"Chemistry; Stereochemistry; Chemical synthesis; Solubility; Combinatorial chemistry; In vitro; Biochemistry; Organic chemistry","score_opus":0.02705580429470753,"score_gpt":0.22099899839779988,"score_spread":0.19394319410309235,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2051798718","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9796149,0.0048948727,0.0063779773,0.00016001253,0.000044150565,0.00026023696,0.0012196741,0.00016716684,0.007261019],"genre_scores_gemma":[0.9750489,0.007155747,0.007313333,0.00019656576,0.000022957522,0.00009710241,0.0029258912,0.00006018799,0.007179305],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998729,0.0000237988,0.000010233717,0.000022994767,0.00003437377,0.000035654484],"domain_scores_gemma":[0.99988115,0.000023624154,0.000016400125,0.000020397249,0.000024171033,0.000034202054],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025735216,0.000564151,0.00048185384,0.0005199949,0.00025142854,0.00034060044,0.00039800967,0.0003053958,0.0021682067],"category_scores_gemma":[0.00021790646,0.00016129707,0.00030816175,0.000469131,0.000189376,0.0003261415,0.000309654,0.00040547675,0.0005234792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005101768,0.0002923864,0.00031859515,0.00018456292,0.000037673264,0.0004613228,0.00006899065,0.0024679166,0.9754812,0.0004165602,0.00027851775,0.01948211],"study_design_scores_gemma":[0.00014374375,0.0025083835,0.0013122719,0.000021623493,0.00006826204,0.00056783104,0.000043087402,0.000608807,0.9844313,0.00013140333,0.01014526,0.000017920438],"about_ca_topic_score_codex":0.0004993096,"about_ca_topic_score_gemma":0.0010265484,"teacher_disagreement_score":0.0021682067,"about_ca_system_score_codex":0.00036960567,"about_ca_system_score_gemma":0.00030200847,"threshold_uncertainty_score":0.0072534084},"labels":[],"label_agreement":null},{"id":"W2052146571","doi":"10.1016/j.bmcl.2013.03.074","title":"Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Moiety; Diazepine; Stereochemistry; Capsid; Structure–activity relationship; Human immunodeficiency virus (HIV); Series (stratigraphy); Enzyme inhibitor; Enzyme; In vitro; Ring (chemistry); Biochemistry; Organic chemistry; Virology","score_opus":0.00965030125485551,"score_gpt":0.20088903390944504,"score_spread":0.19123873265458954,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052146571","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98072356,0.0072370893,0.0034718586,0.00019146298,0.000055921566,0.00027204564,0.00094225473,0.00011383981,0.006991997],"genre_scores_gemma":[0.9849229,0.0042780503,0.004555503,0.00015318986,0.000014290941,0.00006943146,0.0012298538,0.000019075032,0.004757593],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999229,0.000014915729,0.000005827457,0.0000142997205,0.000021868571,0.000020289568],"domain_scores_gemma":[0.9999548,0.000006031274,0.000010217469,0.0000029358505,0.000010092107,0.000015871452],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711495,0.00041202776,0.00035079106,0.00028060717,0.00014484995,0.00029955065,0.00035144095,0.00018356479,0.0016770327],"category_scores_gemma":[0.00011777188,0.0001407825,0.00016264735,0.00022365528,0.00012489929,0.00014025552,0.00014650573,0.0003532023,0.00038023834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00069961156,0.00061806984,0.00053032377,0.0002127046,0.000028464336,0.00024144507,0.00005162515,0.0031472165,0.97360164,0.00042393722,0.00047202056,0.019973043],"study_design_scores_gemma":[0.00085653894,0.0069162617,0.007946108,0.00005315965,0.00014431232,0.00071461615,0.00005311217,0.0061320304,0.95131177,0.00013728772,0.02569064,0.000044116357],"about_ca_topic_score_codex":0.0014042298,"about_ca_topic_score_gemma":0.008343662,"teacher_disagreement_score":0.0016770327,"about_ca_system_score_codex":0.00039716804,"about_ca_system_score_gemma":0.00050108065,"threshold_uncertainty_score":0.0056102276},"labels":[],"label_agreement":null},{"id":"W2052320115","doi":"10.1016/j.bmcl.2012.01.083","title":"Microfluidic technology: An economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET)","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Yield (engineering); Chemical synthesis; Microfluidics; Tyrosine; High-performance liquid chromatography; Chromatography; Combinatorial chemistry; Radiochemistry; In vitro; Nanotechnology; Biochemistry","score_opus":0.018898710287120788,"score_gpt":0.2655431780866356,"score_spread":0.2466444677995148,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052320115","genre_codex":"empirical","genre_gemma":"methods","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"methods","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5722335,0.02811584,0.38055345,0.0026497238,0.0012374849,0.0003139951,0.0015795253,0.0021841333,0.011132389],"genre_scores_gemma":[0.8471448,0.0071696504,0.13623191,0.0004550326,0.00016964112,0.00022538574,0.0005661862,0.00007563465,0.007961741],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984014,0.00001858468,0.000011393908,0.000052854644,0.000039630493,0.00003739002],"domain_scores_gemma":[0.99993527,0.000022989296,0.000020381902,0.0000049226974,0.000006630907,0.000009801957],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032159165,0.00041519266,0.00026450527,0.0002411222,0.000216446,0.00035567523,0.00046582366,0.00056244584,0.0008444291],"category_scores_gemma":[0.00027301614,0.0002623911,0.00021813596,0.00012880615,0.0002621431,0.00051298446,0.00035757097,0.00042942946,0.00039899888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000058052476,0.00001887971,0.00011473987,0.00009594988,0.0000075809603,0.00007825572,0.000022053155,0.00013437317,0.9855473,0.0010913382,0.00059292803,0.012238493],"study_design_scores_gemma":[0.0000150244305,0.00008150406,0.00052047655,0.0000059881727,0.000008861228,0.00040176517,0.0000061959176,0.0010735778,0.9885959,0.00014732772,0.009130713,0.000012686867],"about_ca_topic_score_codex":0.000604991,"about_ca_topic_score_gemma":0.0010037548,"teacher_disagreement_score":0.0008444291,"about_ca_system_score_codex":0.0005536291,"about_ca_system_score_gemma":0.00042468475,"threshold_uncertainty_score":0.0040168166},"labels":[],"label_agreement":null},{"id":"W2052496863","doi":"10.1016/s0960-894x(99)00669-1","title":"Exploring the chiral space within the active site of α-thrombin with a constrained mimic of d-Phe-Pro-Arg — design, synthesis, inhibitory activity, and X-ray structure of an enzyme–inhibitor complex","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"AstraZeneca","keywords":"Chemistry; Thrombin; Active site; Stereochemistry; Enzyme inhibitor; Enzyme; Binding site; Selectivity; Discovery and development of direct thrombin inhibitors; Inhibitory postsynaptic potential; Amino acid; Trypsin; Biochemistry; Catalysis","score_opus":0.02089953334071355,"score_gpt":0.2151614584560828,"score_spread":0.19426192511536927,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052496863","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9834078,0.00086835877,0.013046212,0.00014739203,0.000015631069,0.00006383052,0.00009787585,0.000079952,0.0022729824],"genre_scores_gemma":[0.99010193,0.0005568688,0.008277712,0.00004299192,0.0000041659005,0.00001977699,0.00010206487,0.00001602208,0.00087843393],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990773,0.00001825411,0.0000068361974,0.000020220687,0.000029568686,0.000017449218],"domain_scores_gemma":[0.99990034,0.000024593715,0.000024090677,0.000010415195,0.000008420191,0.0000321412],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002171979,0.00030036023,0.00034928773,0.00012748549,0.00020805621,0.0006844762,0.00057029235,0.00023784928,0.00083729415],"category_scores_gemma":[0.00025886018,0.0002630888,0.00018133438,0.00016977654,0.00027642658,0.00020682596,0.00023333155,0.00051286886,0.00020421811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006700194,0.00013844419,0.00060777226,0.000083180305,0.000026330319,0.0004621188,0.00007113174,0.017179584,0.9698592,0.0020777408,0.0002037124,0.008620722],"study_design_scores_gemma":[0.00017667313,0.0006881043,0.00044312407,0.00000850614,0.00004477676,0.00043292207,0.00003696851,0.02054118,0.97372425,0.00017667953,0.003703604,0.000023231207],"about_ca_topic_score_codex":0.001416817,"about_ca_topic_score_gemma":0.0015437574,"teacher_disagreement_score":0.001416817,"about_ca_system_score_codex":0.000519338,"about_ca_system_score_gemma":0.00038298042,"threshold_uncertainty_score":0.0037680864},"labels":[],"label_agreement":null},{"id":"W2052966458","doi":"10.1016/j.bmcl.2010.07.132","title":"Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: A search for novel cyclooxygenase and lipoxygenase inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Pharmacophore; Stereochemistry; Linker; Methylene; Ring (chemistry); Cyclooxygenase; Indole test; Arachidonate 5-lipoxygenase; Chemical synthesis; Structure–activity relationship; In vivo; Enzyme; Medicinal chemistry; In vitro; Arachidonic acid; Biochemistry; Organic chemistry","score_opus":0.033253068944856294,"score_gpt":0.2818667162966988,"score_spread":0.2486136473518425,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2052966458","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98606735,0.00688336,0.0032315392,0.00015441485,0.00006763742,0.0002529576,0.00069618126,0.000046801506,0.0025998694],"genre_scores_gemma":[0.9885797,0.004869178,0.0037023225,0.000052364943,0.00003696758,0.00009243848,0.0008583462,0.000009266527,0.0017992944],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999262,0.000020055817,0.000009570883,0.000009101682,0.0000134117945,0.0000215918],"domain_scores_gemma":[0.9999348,0.000012296373,0.000016171665,0.000008548242,0.000010092058,0.000017996463],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019403343,0.00030903114,0.00036067067,0.00029456592,0.00022460238,0.00016759617,0.00037873286,0.00026211858,0.0015793316],"category_scores_gemma":[0.0002174223,0.00015818713,0.00026247746,0.00022936889,0.00018433583,0.00023626126,0.00011225048,0.0002730065,0.0002855596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018981493,0.00043135352,0.00030038983,0.0002625597,0.000030911982,0.0006153204,0.000069981776,0.0013723547,0.98066795,0.00035930017,0.0002094976,0.01378228],"study_design_scores_gemma":[0.00064733654,0.00870707,0.0020470486,0.000022067457,0.00014753614,0.00076811144,0.000050188504,0.0009022321,0.97831875,0.000075655866,0.008293224,0.000020691901],"about_ca_topic_score_codex":0.00053001195,"about_ca_topic_score_gemma":0.0010434864,"teacher_disagreement_score":0.0015793316,"about_ca_system_score_codex":0.00019075879,"about_ca_system_score_gemma":0.00030172756,"threshold_uncertainty_score":0.0052834153},"labels":[],"label_agreement":null},{"id":"W2053314320","doi":"10.1016/j.bmcl.2014.12.045","title":"Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Potency; NS5A; Benzimidazole; Chemistry; Pharmacology; Genotype; Replicon; Drug discovery; Stereochemistry; In vitro; Hepacivirus; Biochemistry; Medicine","score_opus":0.006819221958059597,"score_gpt":0.24850626424273387,"score_spread":0.24168704228467427,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2053314320","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9949732,0.0020766992,0.0002869322,0.00007919252,0.000054237647,0.000021458001,0.00018041236,0.000074879,0.002252974],"genre_scores_gemma":[0.99697137,0.0010236936,0.00067807065,0.00004135005,0.000017046945,0.00001094294,0.00019072958,0.00002167374,0.001045178],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997925,0.000054330867,0.000019492001,0.000026278529,0.000031844666,0.00007553496],"domain_scores_gemma":[0.99979764,0.00007158298,0.000032082353,0.000016216114,0.000023541892,0.000058860096],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031238224,0.00032434988,0.0005187001,0.00022989394,0.00027423233,0.00043094615,0.0006349171,0.00040193845,0.0031662951],"category_scores_gemma":[0.0006275776,0.0002197685,0.00021942385,0.00028632153,0.00027146892,0.0004443031,0.000216669,0.00058657496,0.00046092583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.026123285,0.0011598371,0.0010913924,0.00035736556,0.00012334791,0.0005350643,0.00019190506,0.004460486,0.92474836,0.0010225448,0.0017831015,0.038403347],"study_design_scores_gemma":[0.0018513696,0.017406119,0.005078142,0.000046534748,0.00025579004,0.00061524386,0.00010593597,0.007938162,0.9604652,0.00017739719,0.0059696496,0.000090317815],"about_ca_topic_score_codex":0.003898204,"about_ca_topic_score_gemma":0.009321238,"teacher_disagreement_score":0.003898204,"about_ca_system_score_codex":0.00040881423,"about_ca_system_score_gemma":0.00049198326,"threshold_uncertainty_score":0.010592282},"labels":[],"label_agreement":null},{"id":"W2053452104","doi":"10.1016/j.bmcl.2012.01.063","title":"Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Stereochemistry; Phenylalanine; Antagonist; Opioid receptor; Opioid antagonist; Antagonism; Receptor; Opioid; (+)-Naloxone; Amino acid; Biochemistry","score_opus":0.019231741185221175,"score_gpt":0.2422838511701989,"score_spread":0.22305210998497774,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2053452104","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9714793,0.00566124,0.010892124,0.000361201,0.0001282843,0.0002655467,0.0011314017,0.00018906809,0.009891728],"genre_scores_gemma":[0.984994,0.003765358,0.0061029904,0.00031828755,0.000032047737,0.00019717608,0.0008312792,0.000025015517,0.0037338384],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991286,0.000012426342,0.000007252861,0.000015878339,0.000021773001,0.00002978748],"domain_scores_gemma":[0.99993217,0.000014370752,0.000012412701,0.0000061113155,0.0000073800247,0.000027546032],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497557,0.00035225655,0.00033892144,0.00017101932,0.00014864432,0.000288169,0.0005615874,0.0003895593,0.002309694],"category_scores_gemma":[0.00021266317,0.00022022618,0.00017747401,0.0001793437,0.00018564037,0.0003398512,0.00031109326,0.0008343593,0.0005920607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00055511174,0.0001393122,0.00011189449,0.00018166736,0.000020760257,0.0005474649,0.000048032052,0.0007643389,0.9819775,0.00059645856,0.00049558055,0.014561866],"study_design_scores_gemma":[0.0006495404,0.0036076172,0.0021013604,0.000035946185,0.00006958567,0.0027734546,0.00005337476,0.0019164212,0.9762171,0.0003165242,0.012202066,0.000057007972],"about_ca_topic_score_codex":0.00019653427,"about_ca_topic_score_gemma":0.0004643456,"teacher_disagreement_score":0.002309694,"about_ca_system_score_codex":0.00025127878,"about_ca_system_score_gemma":0.00014329702,"threshold_uncertainty_score":0.0077266693},"labels":[],"label_agreement":null},{"id":"W2053941861","doi":"10.1016/j.bmcl.2010.07.044","title":"A stable analog of isochorismate for the study of MenD and other isochorismate-utilizing enzymes","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Enzyme; Stereochemistry; Substrate (aquarium); Substituent; Michaelis–Menten kinetics; Enzyme assay; Biochemistry","score_opus":0.014804423464520407,"score_gpt":0.27480119547610327,"score_spread":0.25999677201158283,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2053941861","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93916506,0.005974431,0.044942036,0.0004282179,0.0002634616,0.00031432338,0.0008720105,0.00017710088,0.007863479],"genre_scores_gemma":[0.97765666,0.0022712245,0.014541382,0.00010949933,0.000037521153,0.00010474558,0.0009460859,0.000040653893,0.0042922203],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999884,0.00002753152,0.000008657495,0.00002255869,0.00003514464,0.000021982345],"domain_scores_gemma":[0.9998976,0.000019051444,0.000015163446,0.000024217165,0.00001507158,0.000028960636],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003410766,0.00028009986,0.0002779149,0.00029132282,0.00025384713,0.00033158576,0.0006050406,0.00046583786,0.0013556335],"category_scores_gemma":[0.00024533205,0.00014729056,0.00024184308,0.00036714584,0.0002787545,0.00045101106,0.00033617567,0.00074204133,0.00031477748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032856816,0.000081876045,0.0001364167,0.00008074802,0.00001044053,0.00016327066,0.00003778121,0.0004218396,0.99065137,0.002948165,0.00009479102,0.005044796],"study_design_scores_gemma":[0.000077410885,0.000742581,0.00044479183,0.000008011852,0.00001660137,0.00028608224,0.000017560596,0.000567613,0.98583245,0.0005079779,0.01148529,0.000013691905],"about_ca_topic_score_codex":0.00053760473,"about_ca_topic_score_gemma":0.0008010265,"teacher_disagreement_score":0.0013556335,"about_ca_system_score_codex":0.00052673154,"about_ca_system_score_gemma":0.000323816,"threshold_uncertainty_score":0.004535079},"labels":[],"label_agreement":null},{"id":"W2054049414","doi":"10.1016/j.bmcl.2005.10.004","title":"Synthesis and biological activities of nucleoside–estradiol conjugates","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Cytotoxicity; Conjugate; Nucleoside; Chemical synthesis; Stereochemistry; Estrogen receptor; In vitro; Cell culture; Binding affinities; Receptor; Biochemistry; Internal medicine","score_opus":0.030119726935584738,"score_gpt":0.23442379621721512,"score_spread":0.2043040692816304,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054049414","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98975754,0.0033053008,0.0021605364,0.000079942525,0.000031120995,0.000038393842,0.00024577905,0.00003814679,0.004343143],"genre_scores_gemma":[0.9935534,0.0009825818,0.0013652709,0.00002916323,0.000011051983,0.00002370644,0.00036070953,0.000016564525,0.0036575345],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999877,0.000038654114,0.000012667544,0.000021675718,0.000023702927,0.00002635876],"domain_scores_gemma":[0.99988604,0.00004960426,0.000017486971,0.000013061562,0.000012993591,0.000020786842],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002383603,0.0002443765,0.00022671284,0.00017852901,0.00016038165,0.0002537796,0.00021159241,0.00023900044,0.001880099],"category_scores_gemma":[0.00025353368,0.00015380772,0.00012941445,0.00019947525,0.0001609414,0.00016291355,0.00014155274,0.00027072942,0.00030922063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010039204,0.00005491365,0.00028887345,0.00006384521,0.000015855783,0.00013892431,0.00006200725,0.00046490013,0.99088657,0.00049819524,0.00011171753,0.006410267],"study_design_scores_gemma":[0.000026150834,0.00033863747,0.00035522203,0.0000024702426,0.000014842079,0.000096027696,0.0000064115025,0.00017603526,0.9969298,0.000027671409,0.0020238196,0.0000028916165],"about_ca_topic_score_codex":0.0004315223,"about_ca_topic_score_gemma":0.0004543088,"teacher_disagreement_score":0.001880099,"about_ca_system_score_codex":0.00023888561,"about_ca_system_score_gemma":0.00018193103,"threshold_uncertainty_score":0.0062896013},"labels":[],"label_agreement":null},{"id":"W2054103986","doi":"10.1016/j.bmcl.2012.10.126","title":"From a cytotoxic agent to the discovery of a novel antimalarial agent","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Plasmodium falciparum; Antimalarial Agent; Glutathione; IC50; Cytotoxicity; Stereochemistry; Cytotoxic T cell; Drug; Pharmacology; In vitro; Combinatorial chemistry; Drug discovery; Biochemistry; Malaria; Enzyme; Biology; Immunology","score_opus":0.022607290875517893,"score_gpt":0.27044436856673154,"score_spread":0.24783707769121366,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054103986","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.15327795,0.57625467,0.06451182,0.070593335,0.007655133,0.00036324703,0.0009217163,0.00086603663,0.12555604],"genre_scores_gemma":[0.5244471,0.3765471,0.02464652,0.015650773,0.0025864271,0.00017564988,0.0005350921,0.00014794715,0.055263396],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998288,0.00002944746,0.00001545852,0.000030059662,0.000064305306,0.000031777075],"domain_scores_gemma":[0.99977106,0.000059090926,0.000020662628,0.00002963106,0.00006640059,0.000053261138],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043282495,0.00044687325,0.0005574519,0.0007764639,0.0004967348,0.0018747795,0.00064328575,0.000976789,0.0033058678],"category_scores_gemma":[0.00055021344,0.0003723453,0.0003218223,0.0003677792,0.0015113947,0.0027607752,0.0012694256,0.0026167475,0.0016970242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009238345,0.00045532442,0.0008337689,0.003783153,0.00008885769,0.0022006957,0.00079452107,0.0022786858,0.40755728,0.17160174,0.022147749,0.38733447],"study_design_scores_gemma":[0.0001681189,0.0015933831,0.0008138255,0.00059440755,0.0000935347,0.002407695,0.00038445456,0.0022388925,0.20166302,0.08510862,0.704849,0.000084993844],"about_ca_topic_score_codex":0.00039014744,"about_ca_topic_score_gemma":0.0007027391,"teacher_disagreement_score":0.0033058678,"about_ca_system_score_codex":0.00083623297,"about_ca_system_score_gemma":0.00069760083,"threshold_uncertainty_score":0.011059284},"labels":[],"label_agreement":null},{"id":"W2054216998","doi":"10.1016/j.bmcl.2007.05.067","title":"Optimization of novel combi-molecules: Identification of balanced and mixed bcr-abl/DNA targeting properties","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Leukemia and Lymphoma Society","keywords":"Chemistry; Chronic myelogenous leukemia; ABL; DNA; Tyrosine kinase; Imatinib mesylate; DNA damage; Molecule; Imatinib; Cancer research; In vitro; Molecular biology; Biochemistry; Leukemia; Signal transduction; Genetics; Biology","score_opus":0.013409854932493168,"score_gpt":0.23149767822597928,"score_spread":0.2180878232934861,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054216998","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97968686,0.0015590887,0.014387194,0.00016934217,0.000040242474,0.0002097672,0.00041820676,0.00016941,0.0033598908],"genre_scores_gemma":[0.9756178,0.000602151,0.020622863,0.00008969555,0.0000144021815,0.00016324736,0.00038451664,0.00004627936,0.0024590134],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998609,0.00002328299,0.000013339487,0.00002960011,0.000054007305,0.000018827612],"domain_scores_gemma":[0.9998622,0.000034155088,0.00004232939,0.000010626189,0.000029844543,0.000020885896],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029858205,0.00033719043,0.00030585268,0.00024285026,0.00012738159,0.00047591783,0.00023946713,0.000352443,0.0018058547],"category_scores_gemma":[0.00044873529,0.00018918,0.00012709356,0.00022247214,0.00013042497,0.0003797589,0.00019381303,0.00032484223,0.00046359436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00041701447,0.00017727846,0.00030423974,0.000077373916,0.000014819863,0.000030012097,0.00001820838,0.0014364768,0.98148537,0.00046429576,0.00020763838,0.015367235],"study_design_scores_gemma":[0.00013212682,0.0005240622,0.00050338,0.0000039414163,0.000022679986,0.000070959395,0.000008775624,0.0068567884,0.98834896,0.00005178155,0.003468347,0.000008224422],"about_ca_topic_score_codex":0.00016801426,"about_ca_topic_score_gemma":0.00050584454,"teacher_disagreement_score":0.0018058547,"about_ca_system_score_codex":0.0003296932,"about_ca_system_score_gemma":0.00019344618,"threshold_uncertainty_score":0.006041169},"labels":[],"label_agreement":null},{"id":"W2054627859","doi":"10.1016/s0960-894x(00)00660-0","title":"Stereospecific synthesis of (2S)-2-methyl-3-(2′,6′-dimethyl-4′-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Medical Research Council","keywords":"Chemistry; Stereospecificity; Stereochemistry; Opioid peptide; Enkephalin; Antagonist; Opioid; Opioid receptor; Opioid antagonist; Peptide; Amino acid; Alkylation; Tyrosine; Receptor; (+)-Naloxone; Biochemistry; Catalysis","score_opus":0.02335509280715567,"score_gpt":0.2446555958423085,"score_spread":0.22130050303515283,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054627859","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92650545,0.002740994,0.048355952,0.00036500714,0.00029867195,0.00036778714,0.002194108,0.0004438137,0.018728206],"genre_scores_gemma":[0.9776038,0.0012633335,0.012954763,0.000079304235,0.000037439273,0.000119662946,0.0009518269,0.00006208819,0.0069279154],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998031,0.000021830905,0.000014655346,0.000039192895,0.000032833694,0.00008841272],"domain_scores_gemma":[0.9998578,0.00001558919,0.00002810192,0.000023264207,0.000025268886,0.000049933915],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028172717,0.00061001355,0.00036525942,0.00037743725,0.0003235441,0.00029544233,0.00070702826,0.00053244573,0.001948087],"category_scores_gemma":[0.00020634652,0.00023696465,0.00032713552,0.0004245253,0.00022602649,0.0004208945,0.00043863727,0.00056156947,0.00089008553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018711793,0.00005796682,0.00007388644,0.00007565491,0.000012697592,0.0003176797,0.00005641633,0.0005204804,0.99249834,0.0009577509,0.00014070289,0.0051012724],"study_design_scores_gemma":[0.000020770047,0.00024691533,0.0003827477,0.0000031072623,0.000010256249,0.00013532204,0.000013215623,0.00036578925,0.9954034,0.00009392946,0.0033130166,0.000011514467],"about_ca_topic_score_codex":0.0014386092,"about_ca_topic_score_gemma":0.0013435956,"teacher_disagreement_score":0.001948087,"about_ca_system_score_codex":0.00045608415,"about_ca_system_score_gemma":0.000813365,"threshold_uncertainty_score":0.006516993},"labels":[],"label_agreement":null},{"id":"W2054703352","doi":"10.1016/j.bmcl.2007.05.031","title":"Synthesis and structure–activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-β inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Stereochemistry; Structure–activity relationship; Bicyclic molecule; Chemical synthesis; In vitro; Biochemistry","score_opus":0.013702446804471814,"score_gpt":0.23080476872444453,"score_spread":0.21710232191997272,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054703352","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95014644,0.0245605,0.008377242,0.00045309926,0.00014311224,0.00040270668,0.0012567464,0.00023460925,0.01442547],"genre_scores_gemma":[0.98043424,0.009761866,0.0035606972,0.00009727876,0.0000424665,0.000095018135,0.00062179833,0.000016764869,0.005370051],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999305,0.000015133952,0.0000071034506,0.000010487673,0.0000121067,0.000024580202],"domain_scores_gemma":[0.9999534,0.000008154809,0.000014279851,0.000004785437,0.000005795445,0.000013487799],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022939294,0.00031727337,0.00032515143,0.0003254591,0.00019181208,0.00026133403,0.00038366814,0.00021637297,0.0020847793],"category_scores_gemma":[0.00015483215,0.00020611272,0.00019609886,0.00024224809,0.00016896581,0.00021396793,0.00017229024,0.00038049344,0.00045861097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013376973,0.0003672234,0.00042153272,0.0005087893,0.000039773204,0.00057875994,0.00019088772,0.003928218,0.95850843,0.0018991962,0.0009964509,0.031223094],"study_design_scores_gemma":[0.00096724246,0.009485745,0.006669073,0.000062926,0.00014201814,0.0010588538,0.00007558937,0.004764063,0.9503747,0.0004612565,0.02588839,0.00005009746],"about_ca_topic_score_codex":0.00089209055,"about_ca_topic_score_gemma":0.0019423558,"teacher_disagreement_score":0.0020847793,"about_ca_system_score_codex":0.00031761295,"about_ca_system_score_gemma":0.00030104973,"threshold_uncertainty_score":0.0069743395},"labels":[],"label_agreement":null},{"id":"W2055100907","doi":"10.1016/j.bmcl.2004.09.010","title":"Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Chemistry; Lead compound; Antagonist; Chemical synthesis; Pharmacology; Carboxamide; IC50; Chemical library; Stereochemistry; Structure–activity relationship; Biological activity; HEK 293 cells; Capsaicin; Receptor; In vitro; Biochemistry; Small molecule","score_opus":0.02511497816724321,"score_gpt":0.2696292538216431,"score_spread":0.2445142756543999,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2055100907","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9455298,0.017304335,0.02185054,0.0007319532,0.00021986465,0.0007844994,0.0013774172,0.00032799598,0.011873632],"genre_scores_gemma":[0.9724698,0.010576237,0.00957666,0.00020987401,0.000056290704,0.00018349497,0.0010908279,0.00003632024,0.0058004027],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998969,0.000017197932,0.000011577945,0.000015707203,0.000023516,0.000035213336],"domain_scores_gemma":[0.99994886,0.000008903567,0.000012965107,0.0000048594766,0.000008824478,0.000015512347],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330172,0.0003488927,0.0004733724,0.00028790015,0.00022514055,0.0002896208,0.00047765233,0.00034600793,0.0016278095],"category_scores_gemma":[0.00022440012,0.00027664436,0.00022806655,0.00020798184,0.00017474999,0.00036336176,0.00023271056,0.0006111824,0.00041046474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000847573,0.00024385344,0.00021146226,0.00039528153,0.000048773294,0.00053794746,0.0001111564,0.0025678473,0.9571724,0.0016404743,0.0006308117,0.035592467],"study_design_scores_gemma":[0.00073321664,0.0062668948,0.0022827587,0.000044845237,0.00014041396,0.0009113405,0.000043313674,0.0028217128,0.961839,0.0004204526,0.02445321,0.000042723324],"about_ca_topic_score_codex":0.00060967816,"about_ca_topic_score_gemma":0.0010773732,"teacher_disagreement_score":0.0016278095,"about_ca_system_score_codex":0.00030539083,"about_ca_system_score_gemma":0.0003091935,"threshold_uncertainty_score":0.00544554},"labels":[],"label_agreement":null},{"id":"W2055148246","doi":"10.1016/s0960-894x(00)00322-x","title":"5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Chemistry; Ethylamine; Stereochemistry; Indole test; Chemical synthesis; Agonist; Structure–activity relationship; Side chain; Receptor; Pharmacology; In vitro; Biochemistry; Organic chemistry","score_opus":0.007428467506783858,"score_gpt":0.23504351171855384,"score_spread":0.22761504421176998,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2055148246","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97823125,0.014077449,0.0013033209,0.00014683,0.0000848729,0.000081979386,0.0003838658,0.00005867984,0.0056317183],"genre_scores_gemma":[0.9865927,0.007830285,0.0009816071,0.00014106513,0.000044123484,0.000029907877,0.00050930964,0.0000117191985,0.003859251],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999021,0.000032747943,0.000008050947,0.000009890234,0.000017161274,0.000029923827],"domain_scores_gemma":[0.99994683,0.000017623295,0.000009891676,0.0000051587613,0.0000053420094,0.0000151838],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022240108,0.00020763825,0.00028912697,0.00023351381,0.0001558872,0.00016772757,0.00032857267,0.00024415553,0.0023421072],"category_scores_gemma":[0.00017245165,0.00017723201,0.00015733812,0.000167682,0.00014135298,0.00022390088,0.0001920119,0.00047751307,0.00048904505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002439798,0.00026248003,0.00043635818,0.00028102341,0.000058233487,0.00046509417,0.00013444987,0.0005010035,0.9706588,0.0007443061,0.00058219326,0.023436338],"study_design_scores_gemma":[0.001336971,0.024640393,0.014156131,0.00006260334,0.00033102013,0.0027010313,0.00014565156,0.001904664,0.92760485,0.0002709549,0.02679551,0.000050179533],"about_ca_topic_score_codex":0.00077055895,"about_ca_topic_score_gemma":0.0037062336,"teacher_disagreement_score":0.0023421072,"about_ca_system_score_codex":0.00017219712,"about_ca_system_score_gemma":0.000115017465,"threshold_uncertainty_score":0.00783515},"labels":[],"label_agreement":null},{"id":"W2055283078","doi":"10.1016/s0960-894x(01)00130-5","title":"Design and synthesis of a new Sialyl Lewis X Mimetic: How selective are the selectin receptors?","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Massachusetts General Hospital","keywords":"Chemistry; Enantiomer; Molecular model; Sialyl-Lewis X; Receptor; Stereochemistry; Selectin; Chemical synthesis; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry; Adhesion","score_opus":0.024011623561055902,"score_gpt":0.25647610863514364,"score_spread":0.23246448507408773,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2055283078","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91459394,0.00436891,0.07177362,0.0011208621,0.00021259711,0.00038483698,0.00036350428,0.0002945317,0.0068872236],"genre_scores_gemma":[0.9240969,0.004311739,0.05992903,0.0004962116,0.000055181332,0.00022904223,0.0005050411,0.000045531222,0.010331356],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999429,0.000011554486,0.0000057339216,0.000011112561,0.000012421846,0.000016321826],"domain_scores_gemma":[0.99996686,0.000004348987,0.000008819354,0.0000032578964,0.0000045153574,0.000012157981],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021667521,0.00025528934,0.0002760268,0.00013998001,0.00019950511,0.00032671195,0.0003138692,0.0003477961,0.00095366716],"category_scores_gemma":[0.00014527903,0.00016315919,0.00016537265,0.0001354598,0.00014412073,0.00038975058,0.00019312714,0.0004996236,0.00044950863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020723896,0.00011171656,0.00016427819,0.00013966714,0.000018009465,0.00032753134,0.00008840997,0.0009448991,0.97292644,0.0035212366,0.00053221104,0.021018388],"study_design_scores_gemma":[0.00006683982,0.0005225638,0.00019863324,0.000007077371,0.000024745626,0.00038815686,0.0000262213,0.0017081012,0.9837947,0.0004001332,0.01285054,0.000012228868],"about_ca_topic_score_codex":0.00016224787,"about_ca_topic_score_gemma":0.00026367814,"teacher_disagreement_score":0.00095366716,"about_ca_system_score_codex":0.00026604632,"about_ca_system_score_gemma":0.00027668788,"threshold_uncertainty_score":0.0031903386},"labels":[],"label_agreement":null},{"id":"W2055520535","doi":"10.1016/j.bmcl.2011.10.073","title":"Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Plant-Derived Bioactive Compounds","field":"Chemistry","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Agriculture and Agri-Food Canada","keywords":"Chemistry; Acarbose; Gallic acid; Stereochemistry; Aceraceae; Maple; Antioxidant; Biochemistry; Botany; Enzyme; Biology","score_opus":0.029387365872494273,"score_gpt":0.2053386229766197,"score_spread":0.17595125710412543,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2055520535","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9509192,0.019710582,0.015664525,0.00024774158,0.00009746324,0.00022000284,0.0012141203,0.0007348445,0.011191503],"genre_scores_gemma":[0.98112434,0.005222161,0.0052186833,0.00019929942,0.00003401268,0.000055810826,0.0015339197,0.000038427086,0.0065733795],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999747,0.0000035523344,0.0000016861322,0.0000064820133,0.0000072226,0.000006337373],"domain_scores_gemma":[0.9999682,0.0000041086196,0.000008126786,0.0000025883205,0.000003529881,0.000013460756],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000563108,0.0003820651,0.00027217486,0.00028590174,0.00009527436,0.00029476878,0.00021249676,0.00017898803,0.0010226804],"category_scores_gemma":[0.00006400206,0.00009796833,0.0001534327,0.00013721142,0.00011458931,0.00030484484,0.00015994349,0.00044836776,0.0004068895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025292308,0.0000606616,0.00012481604,0.00020357099,0.000017690543,0.00021448237,0.000028232012,0.0002645376,0.9779283,0.00021389185,0.0002761738,0.020414656],"study_design_scores_gemma":[0.00013650968,0.0012504507,0.004383398,0.00002023968,0.00006692698,0.0008452226,0.000039951577,0.00088085304,0.97318417,0.00019149802,0.018979425,0.000021287482],"about_ca_topic_score_codex":0.00014095135,"about_ca_topic_score_gemma":0.00029409816,"teacher_disagreement_score":0.0010226804,"about_ca_system_score_codex":0.00012217808,"about_ca_system_score_gemma":0.00007186856,"threshold_uncertainty_score":0.0034211874},"labels":[],"label_agreement":null},{"id":"W2055760422","doi":"10.1016/j.bmcl.2010.07.027","title":"Introduction of guanidinium-modified deoxyuridine into the substrate binding regions of DNAzyme 10–23 to enhance target affinity: Implications for DNAzyme design","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Deoxyribozyme; Chemistry; Oligonucleotide; Combinatorial chemistry; RNA; Phosphoramidite; Deoxyuridine; DNA; Duplex (building); Nucleic acid; Stereochemistry; Biochemistry","score_opus":0.014662193257976708,"score_gpt":0.285317785349768,"score_spread":0.2706555920917913,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2055760422","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9635456,0.0014228136,0.031901352,0.000394671,0.00014416988,0.00011985227,0.00013537955,0.00031856477,0.0020175353],"genre_scores_gemma":[0.9600618,0.00064098265,0.036295805,0.00026746956,0.000018158082,0.00006637005,0.00023202902,0.00009349124,0.0023238468],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977285,0.000049211732,0.000021955411,0.000059962193,0.000051883948,0.00004423009],"domain_scores_gemma":[0.99956256,0.0001390679,0.00009697186,0.000064773245,0.000052779837,0.00008381753],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00058865955,0.0003545663,0.00038056818,0.000103116865,0.00019159273,0.00050710025,0.00060830166,0.00077531784,0.0010582776],"category_scores_gemma":[0.00084414595,0.00034672266,0.00029770035,0.00011110495,0.0003814808,0.00033357917,0.0002113549,0.0011118847,0.0004530829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000073350064,0.000025817733,0.000055251752,0.000035899586,0.0000040226128,0.000049807048,0.000021389451,0.000107689884,0.9982948,0.00011140732,0.000018829593,0.0012017942],"study_design_scores_gemma":[0.0000109488055,0.00014482094,0.00014157804,0.0000022849745,0.00000589904,0.00009410638,0.0000043898776,0.0002818689,0.99846494,0.00001690836,0.0008281342,0.0000040423324],"about_ca_topic_score_codex":0.0005971729,"about_ca_topic_score_gemma":0.0013392658,"teacher_disagreement_score":0.0010582776,"about_ca_system_score_codex":0.00043357344,"about_ca_system_score_gemma":0.00041680312,"threshold_uncertainty_score":0.0035402775},"labels":[],"label_agreement":null},{"id":"W2055779054","doi":"10.1016/j.bmcl.2011.01.006","title":"Trisubstituted ureas as potent and selective mPGES-1 inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; IC50; Enzyme; Prostanoid; Reductive amination; Combinatorial chemistry; Amination; ATP synthase; Biochemistry; Enzyme inhibitor; Chemical synthesis; Stereochemistry; In vitro; Receptor","score_opus":0.011471227718450099,"score_gpt":0.2156171236581565,"score_spread":0.2041458959397064,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2055779054","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9556216,0.021802332,0.007067739,0.00034672805,0.00033061428,0.00021190048,0.00074122305,0.00043217101,0.01344569],"genre_scores_gemma":[0.98305964,0.007866258,0.0034567544,0.0001670989,0.0000621463,0.000098080265,0.0004484016,0.000027650723,0.0048139906],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999207,0.000016222566,0.000006135293,0.0000100069565,0.000018581748,0.000028347402],"domain_scores_gemma":[0.99996245,0.000005621224,0.000008569423,0.0000039060333,0.000006428934,0.000012992725],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385035,0.00034459916,0.00029996588,0.00022282836,0.000138858,0.00017061879,0.0003957834,0.00021196356,0.0018039545],"category_scores_gemma":[0.00014051776,0.00017311015,0.00013849621,0.0001786213,0.00014134462,0.00030478818,0.0002667247,0.0005660165,0.0003894934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008411263,0.00021418987,0.00018953401,0.00028559018,0.0000340273,0.0003272308,0.000087910645,0.0016570904,0.952739,0.0020732584,0.0015714989,0.03997956],"study_design_scores_gemma":[0.00032866478,0.004523483,0.0013781997,0.000034638437,0.00006692734,0.0005548078,0.000029819277,0.0025795363,0.96942127,0.00027845468,0.0207647,0.00003946677],"about_ca_topic_score_codex":0.00052696257,"about_ca_topic_score_gemma":0.0020708917,"teacher_disagreement_score":0.0018039545,"about_ca_system_score_codex":0.00028793776,"about_ca_system_score_gemma":0.00021039402,"threshold_uncertainty_score":0.006034851},"labels":[],"label_agreement":null},{"id":"W2056193241","doi":"10.1016/j.bmcl.2011.06.068","title":"Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Dihydroxylation; Amaryllidaceae Alkaloids; Regioselectivity; Stereochemistry; Aziridine; Chemical synthesis; Intramolecular force; Cleavage (geology); Sulfoxide; Enantioselective synthesis; Catalysis; Alkaloid; Organic chemistry; Biochemistry; Ring (chemistry)","score_opus":0.03536769618345167,"score_gpt":0.22245608928868865,"score_spread":0.18708839310523698,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056193241","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9753019,0.004127542,0.0054820636,0.00021040576,0.00010824647,0.0004919877,0.00199739,0.00009255166,0.012187983],"genre_scores_gemma":[0.98704475,0.0023886173,0.005086564,0.0001123515,0.000029135244,0.000069825925,0.001504962,0.00001738098,0.0037464113],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985766,0.00002612501,0.000013216249,0.000026714926,0.000033909313,0.00004236603],"domain_scores_gemma":[0.9998441,0.000020849795,0.000026766282,0.00002091087,0.000042450913,0.000044944212],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022193042,0.000192163,0.0002255075,0.00019870662,0.00021033364,0.00016358367,0.00030264343,0.00030878963,0.0017208299],"category_scores_gemma":[0.00038124286,0.00008285304,0.00021595311,0.00028160872,0.00015863395,0.00024475637,0.00019918219,0.000482899,0.00059591315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010306679,0.00017420003,0.00041465016,0.00031663867,0.000031056956,0.0007336208,0.00013409769,0.0017995905,0.9787771,0.0007506493,0.00056308554,0.015274763],"study_design_scores_gemma":[0.00015762843,0.0059393398,0.0036068214,0.000021345244,0.00005749947,0.0012893121,0.00008477134,0.0014728043,0.9637418,0.00027859595,0.023317896,0.00003229466],"about_ca_topic_score_codex":0.0010696407,"about_ca_topic_score_gemma":0.001099299,"teacher_disagreement_score":0.0017208299,"about_ca_system_score_codex":0.00025702262,"about_ca_system_score_gemma":0.00034172708,"threshold_uncertainty_score":0.005756676},"labels":[],"label_agreement":null},{"id":"W2056377087","doi":"10.1016/j.bmcl.2010.08.020","title":"Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: The effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring α-glucosidase inhibitor","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo; Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Active site; Moiety; Stereochemistry; Sulfonium; Ether; Maltase; Glycosyl; Nucleophile; Enzyme; Organic chemistry; Catalysis; Salt (chemistry)","score_opus":0.007643123777622384,"score_gpt":0.24284888513848008,"score_spread":0.2352057613608577,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056377087","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99854916,0.0003753198,0.0006972229,0.000044765835,0.000006068754,0.0000074551826,0.000072871844,0.000011147446,0.00023600775],"genre_scores_gemma":[0.9982027,0.00037338986,0.0009209054,0.000022144515,0.00000470041,0.0000058085398,0.00013903718,0.000010048056,0.00032127986],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999899,0.000024552088,0.000008637593,0.000016836291,0.000027966138,0.000023033428],"domain_scores_gemma":[0.9999075,0.00004295424,0.0000186763,0.000008521798,0.000008058941,0.00001419599],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020709333,0.0002619135,0.00024205784,0.00006872033,0.000090224705,0.0002301854,0.00030611758,0.00032096222,0.00096193986],"category_scores_gemma":[0.00023878882,0.0001751143,0.00014720827,0.00008663784,0.00028724762,0.0002712495,0.00010609155,0.00050149515,0.0002219831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00059710216,0.00003120034,0.000121702404,0.000021852775,0.0000048904685,0.00003269075,0.000010017617,0.00026898875,0.99781895,0.0000673039,0.00001436154,0.0010109257],"study_design_scores_gemma":[0.000037078134,0.00036200054,0.00045571907,0.0000012626267,0.000010724439,0.00012206525,0.000008231947,0.00074408256,0.99778146,0.000025616004,0.00044788534,0.0000039278916],"about_ca_topic_score_codex":0.0005255939,"about_ca_topic_score_gemma":0.00070463796,"teacher_disagreement_score":0.00096193986,"about_ca_system_score_codex":0.000218717,"about_ca_system_score_gemma":0.00018231185,"threshold_uncertainty_score":0.0032179952},"labels":[],"label_agreement":null},{"id":"W2056465831","doi":"10.1016/s0960-894x(01)00601-1","title":"The discovery of anthranilic acid-based mmp inhibitors. Part 3: incorporation of basic amines","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Anthranilic acid; Piperazine; In vivo; Matrix metalloproteinase; Chemical synthesis; In vitro; Enzyme inhibitor; Stereochemistry; Pharmacology; Biochemistry; Combinatorial chemistry; Organic chemistry","score_opus":0.008043333788321302,"score_gpt":0.2121543083177723,"score_spread":0.20411097452945098,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056465831","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7351539,0.17990246,0.05978827,0.0018105714,0.00093320786,0.00037383765,0.0005371485,0.00062145607,0.020879157],"genre_scores_gemma":[0.8665834,0.095476404,0.01825401,0.0004870256,0.0003080829,0.0001220123,0.00032395133,0.00005289109,0.01839231],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999254,0.000013522543,0.0000058014098,0.000013859271,0.00002370602,0.00001766987],"domain_scores_gemma":[0.9999449,0.000014373184,0.000013268337,0.000005999513,0.000008492715,0.000012995756],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028631827,0.00048129246,0.0002886744,0.00024413434,0.000109412875,0.0003493365,0.0003118969,0.00036810365,0.0011873336],"category_scores_gemma":[0.00019935849,0.0002381597,0.00028822533,0.00014410245,0.00029829185,0.0004709694,0.00020275058,0.00051177666,0.0005061494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026921605,0.00011457644,0.00013146718,0.00038430843,0.000019950678,0.0001845563,0.000046904242,0.0006426617,0.9520734,0.002561712,0.0006579977,0.042913232],"study_design_scores_gemma":[0.0000702848,0.00061135,0.0007545742,0.000019632527,0.000026829366,0.00040799208,0.0000073231104,0.0007823354,0.9763218,0.000416192,0.02056976,0.00001180567],"about_ca_topic_score_codex":0.00020210362,"about_ca_topic_score_gemma":0.0002353967,"teacher_disagreement_score":0.0011873336,"about_ca_system_score_codex":0.00026960252,"about_ca_system_score_gemma":0.00013849832,"threshold_uncertainty_score":0.003971994},"labels":[],"label_agreement":null},{"id":"W2056472275","doi":"10.1016/j.bmcl.2008.05.073","title":"Novel benzimidazole derivatives as selective CB2 agonists","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Benzimidazole; Agonist; Affinities; Selectivity; Moiety; Partial agonist; Binding affinities; Stereochemistry; Receptor; Chemical synthesis; Cannabinoid receptor type 2; Pharmacology; Combinatorial chemistry; Cannabinoid receptor; Biochemistry; In vitro; Organic chemistry","score_opus":0.018519400568622092,"score_gpt":0.2695736697128926,"score_spread":0.2510542691442705,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056472275","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.88384634,0.042477235,0.0073576663,0.0016507782,0.000649118,0.00034916544,0.0015500516,0.0007600423,0.06135955],"genre_scores_gemma":[0.96595484,0.013583784,0.0025672026,0.00035348604,0.00010508313,0.00009017556,0.00087829883,0.000038392067,0.016428638],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998976,0.000015161985,0.0000064201595,0.000012768596,0.000019226887,0.000048814414],"domain_scores_gemma":[0.99996686,0.0000063003113,0.0000065371323,0.0000037410325,0.00000544222,0.000011048124],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017837588,0.0004445238,0.00041283018,0.0003242327,0.00038300303,0.00035962212,0.00083663303,0.00036818086,0.007141646],"category_scores_gemma":[0.0001509023,0.00019851346,0.00019445588,0.0003150222,0.00025155922,0.00031622732,0.00030163352,0.0008305704,0.001185923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018624917,0.0004216194,0.000369476,0.000777996,0.000047856785,0.0009908543,0.00028328167,0.0013749173,0.9103381,0.0051217647,0.0057663033,0.072645284],"study_design_scores_gemma":[0.0011474462,0.0061915754,0.005300223,0.000114422095,0.00020072378,0.002224113,0.00015330712,0.0039010844,0.86105853,0.00084064406,0.11875257,0.00011532941],"about_ca_topic_score_codex":0.0025466355,"about_ca_topic_score_gemma":0.008557113,"teacher_disagreement_score":0.007141646,"about_ca_system_score_codex":0.0007317833,"about_ca_system_score_gemma":0.00028948608,"threshold_uncertainty_score":0.02389121},"labels":[],"label_agreement":null},{"id":"W2056498469","doi":"10.1016/j.bmcl.2013.01.001","title":"Corrigendum to “Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 1924–1927]","year":2013,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Stereochemistry; Combinatorial chemistry","score_opus":0.013798697267725677,"score_gpt":0.21031837048127158,"score_spread":0.1965196732135459,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056498469","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00026149393,0.0062514404,0.0013690604,0.022550931,0.9550627,0.00009989021,0.0020561225,0.00048800034,0.011860327],"genre_scores_gemma":[0.012043587,0.03270651,0.0069466354,0.051486038,0.14019008,0.00039991405,0.010109623,0.0010802964,0.7450372],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9971986,0.00022445417,0.00032228197,0.00043395712,0.0013458431,0.00047499643],"domain_scores_gemma":[0.9948768,0.0008057947,0.00036134885,0.00035038096,0.003122572,0.00048308782],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0019131973,0.00347992,0.003442076,0.0029569773,0.0034777434,0.0024626614,0.005770376,0.005902529,0.15875779],"category_scores_gemma":[0.011290624,0.0017161341,0.003052405,0.0033836982,0.0014977134,0.002509763,0.0022808698,0.0053764195,0.079786494],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006393256,0.00002533099,0.000034325523,0.00036838857,0.000022074451,0.0003191587,0.000015609752,0.00014194776,0.0008060297,0.00070470775,0.9886691,0.008829446],"study_design_scores_gemma":[0.000060861876,0.000065635075,0.00088480616,0.00014078525,0.0000653767,0.0003220508,0.00003236551,0.00032026155,0.0041181166,0.00087949936,0.99305093,0.00005943954],"about_ca_topic_score_codex":0.01954144,"about_ca_topic_score_gemma":0.03200064,"teacher_disagreement_score":0.15875779,"about_ca_system_score_codex":0.0054193973,"about_ca_system_score_gemma":0.004097053,"threshold_uncertainty_score":0.5310977},"labels":[],"label_agreement":null},{"id":"W2056897790","doi":"10.1016/j.bmcl.2008.01.103","title":"Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Prostanoid; Pharmacokinetics; Pharmacology; Receptor; Quinoline; Potency; Structure–activity relationship; Antagonist; Agonist; Stereochemistry; In vitro; Biochemistry","score_opus":0.013148975568750306,"score_gpt":0.22568914569780746,"score_spread":0.21254017012905715,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056897790","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9955056,0.002781623,0.00080862537,0.00008421634,0.000015237361,0.000020768355,0.00018353344,0.000022038836,0.00057836354],"genre_scores_gemma":[0.997227,0.0013636007,0.0003526275,0.000032656062,0.000021286114,0.000013675727,0.0002546882,0.000006348254,0.00072803366],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998747,0.000059432547,0.000008153468,0.000013366859,0.000017949551,0.000026419202],"domain_scores_gemma":[0.9996811,0.00013735903,0.00009316096,0.000018170522,0.00002829713,0.00004195027],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041795438,0.00021882172,0.00032862564,0.00020561865,0.00009844078,0.00024468917,0.00022584035,0.00016612605,0.0016040662],"category_scores_gemma":[0.0008115736,0.00019458684,0.00021912696,0.00015549616,0.00020599662,0.00025922965,0.00010353433,0.00047245657,0.00023557722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.018367995,0.000672965,0.0033625797,0.0001704834,0.00018111916,0.0003280539,0.00022090887,0.004741826,0.93412936,0.0009025622,0.0009309888,0.035991203],"study_design_scores_gemma":[0.0033746883,0.06769589,0.05726322,0.000035099336,0.0010626196,0.0019785836,0.00027279102,0.03445537,0.8186074,0.0005801565,0.014548453,0.00012573368],"about_ca_topic_score_codex":0.0009684076,"about_ca_topic_score_gemma":0.0014207392,"teacher_disagreement_score":0.0016040662,"about_ca_system_score_codex":0.0002802636,"about_ca_system_score_gemma":0.00019449205,"threshold_uncertainty_score":0.005366206},"labels":[],"label_agreement":null},{"id":"W2056987772","doi":"10.1016/j.bmcl.2014.09.037","title":"Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Aminoglycoside; Chemistry; Bacteria; ANT; Gentamicin; Enzyme; Antibiotics; Microbiology; Biochemistry; Stereochemistry; Biology; Genetics","score_opus":0.003995082417266565,"score_gpt":0.208675049122543,"score_spread":0.20467996670527644,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056987772","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99483514,0.00067669485,0.0019949614,0.00009777586,0.000034106906,0.000024128607,0.00032947471,0.00013074378,0.0018769833],"genre_scores_gemma":[0.9962106,0.00033804914,0.0012757295,0.00002729187,0.000005701623,0.000013098541,0.00030370778,0.0000197437,0.0018060746],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999058,0.00001653058,0.000016179372,0.000012203144,0.00002210779,0.000027137296],"domain_scores_gemma":[0.9998658,0.000029964089,0.000039244347,0.000025435234,0.000010637236,0.000029036124],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008891679,0.00026006912,0.00015557269,0.00011572221,0.00006423085,0.0002236988,0.0002799709,0.00022714536,0.0009832934],"category_scores_gemma":[0.00016455016,0.00013993199,0.00015999505,0.00009098068,0.0001939796,0.0001337401,0.0001470154,0.0004617194,0.00046772978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017210256,0.000021471016,0.00006845303,0.000015100813,0.0000024006129,0.000067757224,0.000008218708,0.00009102241,0.99854624,0.00009316086,0.000026371874,0.000887687],"study_design_scores_gemma":[0.000010305052,0.00010398865,0.0004162913,0.0000014929533,0.0000028259603,0.00008155898,0.0000068593768,0.00028232287,0.99837494,0.000018182829,0.00069943257,0.0000017498426],"about_ca_topic_score_codex":0.0004459422,"about_ca_topic_score_gemma":0.00037551465,"teacher_disagreement_score":0.0009832934,"about_ca_system_score_codex":0.00014823343,"about_ca_system_score_gemma":0.00016505174,"threshold_uncertainty_score":0.0032894611},"labels":[],"label_agreement":null},{"id":"W2057495992","doi":"10.1016/j.bmcl.2014.05.013","title":"Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"OmegaChem (Canada); AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Trifluoromethyl; Aryl; Stereochemistry; Carboxamide; Chemical synthesis; Series (stratigraphy); Organic chemistry; In vitro; Biochemistry; Alkyl","score_opus":0.012733475053165837,"score_gpt":0.22782069990991868,"score_spread":0.21508722485675286,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2057495992","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91236466,0.031229142,0.03243678,0.0011196282,0.00046760368,0.00053325965,0.00094291585,0.0005496686,0.02035645],"genre_scores_gemma":[0.9557259,0.018884169,0.014608798,0.00057243335,0.0001421883,0.0003134466,0.00091066834,0.000050926363,0.008791368],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998692,0.000025165067,0.000008089911,0.000022821918,0.000025527206,0.000049203754],"domain_scores_gemma":[0.9999101,0.000013382422,0.00002738784,0.0000066508605,0.000021281048,0.000021112277],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034112835,0.00051290944,0.00037769967,0.0002935978,0.00021791748,0.00031353335,0.0005842396,0.0003981867,0.0021146517],"category_scores_gemma":[0.0003212258,0.00018939372,0.00034761347,0.0001472831,0.00018330348,0.00030976886,0.0002862124,0.0006649053,0.00075007696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038533582,0.00024328973,0.00027755692,0.0002855502,0.00004218438,0.00033823738,0.00008650935,0.0009962224,0.95923686,0.001744005,0.0014935508,0.0348706],"study_design_scores_gemma":[0.00046761104,0.0062367646,0.003385025,0.00013036472,0.00018128057,0.0015710761,0.00007374631,0.004358433,0.92239106,0.00060519425,0.060532577,0.00006679684],"about_ca_topic_score_codex":0.0004930797,"about_ca_topic_score_gemma":0.001656015,"teacher_disagreement_score":0.0021146517,"about_ca_system_score_codex":0.0003088718,"about_ca_system_score_gemma":0.00023534284,"threshold_uncertainty_score":0.007074237},"labels":[],"label_agreement":null},{"id":"W2057546898","doi":"10.1016/j.bmcl.2009.07.129","title":"Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI)","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Monsanto (Canada)","funders":"","keywords":"Escherichia coli; Staphylococcus aureus; Chemistry; Stereochemistry; Enzyme; Microbiology; Reductase; Bacteria; Biochemistry; Biology; Gene","score_opus":0.006172181857836854,"score_gpt":0.21700654862715119,"score_spread":0.21083436676931433,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2057546898","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9831073,0.009662157,0.0017840376,0.00015505611,0.00010517007,0.00004954814,0.00020935442,0.00015023425,0.0047771605],"genre_scores_gemma":[0.98964256,0.00490393,0.0016195228,0.00008489387,0.000024205923,0.000025423682,0.00024319174,0.000011940934,0.0034444362],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991775,0.000019811105,0.0000069867397,0.000010884576,0.000019444014,0.000025110907],"domain_scores_gemma":[0.9999527,0.000010295021,0.00001169959,0.000004508676,0.0000057908883,0.000014995489],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015985186,0.00022892056,0.00024771018,0.00011462768,0.00007712353,0.00011542332,0.00026540307,0.00017987598,0.0013938998],"category_scores_gemma":[0.00013037313,0.00012250064,0.00010532396,0.00009269413,0.00010675015,0.00013655177,0.00012490025,0.0003482427,0.00034637807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00073175994,0.00012449911,0.00014587105,0.00013255047,0.000011900442,0.00018211843,0.000036368256,0.0005313844,0.9859744,0.00026707634,0.00023100156,0.011631013],"study_design_scores_gemma":[0.00041393752,0.0056340345,0.005373568,0.00003699659,0.00004983865,0.00085645483,0.000043541153,0.0029279024,0.9756698,0.0001398925,0.008832111,0.00002187621],"about_ca_topic_score_codex":0.0004007589,"about_ca_topic_score_gemma":0.0012700574,"teacher_disagreement_score":0.0013938998,"about_ca_system_score_codex":0.00015171834,"about_ca_system_score_gemma":0.00013278441,"threshold_uncertainty_score":0.00466311},"labels":[],"label_agreement":null},{"id":"W2058278593","doi":"10.1016/j.bmcl.2004.11.077","title":"Identification of a UDP-Gal: GlcNAc-R galactosyltransferase activity in Escherichia coli VW187","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University; Kingston General Hospital; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Arthritis Society","keywords":"Galactosyltransferase; Chemistry; Escherichia coli; Substrate (aquarium); Moiety; Glycosyltransferase; Enzyme; Biochemistry; Lipid A; Pyrophosphate; Stereochemistry; Covalent bond; Bacteria; Organic chemistry; Biology","score_opus":0.0095064117781274,"score_gpt":0.2171726834189672,"score_spread":0.2076662716408398,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2058278593","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9955936,0.00025157628,0.0020319442,0.000085653475,0.000018234936,0.000019297955,0.0010469718,0.000043385797,0.00090925966],"genre_scores_gemma":[0.99180436,0.00022680355,0.0018032647,0.000040571835,0.0000073706697,0.000018157603,0.0034401687,0.000029521618,0.002629747],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988997,0.000015576496,0.000011237297,0.00002035196,0.000031361255,0.00003153075],"domain_scores_gemma":[0.9998841,0.000037711678,0.000018508274,0.000019186442,0.000017815044,0.0000227335],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007392008,0.00039065265,0.00032666617,0.0003469303,0.00012763521,0.00049714453,0.00029078923,0.00024172042,0.0008836477],"category_scores_gemma":[0.0002452378,0.00015595113,0.0002951456,0.00037338943,0.0001771065,0.00017703524,0.00025542715,0.00038174947,0.0006349301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018660218,0.00005833821,0.0013689648,0.000035026318,0.000009993129,0.00032291692,0.000047435235,0.00012331663,0.9956494,0.00017749805,0.000081341685,0.0019392095],"study_design_scores_gemma":[0.000010326298,0.00019253089,0.010274325,0.0000063051916,0.000026317974,0.0006862253,0.00020658171,0.0004682025,0.98640347,0.000060302395,0.001658739,0.0000067132373],"about_ca_topic_score_codex":0.0021115316,"about_ca_topic_score_gemma":0.00097231223,"teacher_disagreement_score":0.0021115316,"about_ca_system_score_codex":0.00022895288,"about_ca_system_score_gemma":0.00022861519,"threshold_uncertainty_score":0.004198551},"labels":[],"label_agreement":null},{"id":"W2058381701","doi":"10.1016/j.bmcl.2010.02.036","title":"Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Renin inhibitor; Chemistry; Bioavailability; In vivo; In vitro; Renin–angiotensin system; Pharmacology; Covalent bond; Enzyme inhibitor; Combinatorial chemistry; Biochemistry; Internal medicine; Organic chemistry; Medicine; Biology","score_opus":0.026545221393908615,"score_gpt":0.23026022024298692,"score_spread":0.20371499884907832,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2058381701","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96813256,0.008606934,0.012685831,0.00041526527,0.00017800192,0.0004975049,0.0005096892,0.00015577096,0.008818549],"genre_scores_gemma":[0.97446704,0.006990728,0.01358066,0.00021922075,0.00004989574,0.00014952337,0.00054645125,0.000026598655,0.0039698533],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989843,0.000019785008,0.000011215658,0.000014282145,0.000030814943,0.000025365116],"domain_scores_gemma":[0.9999325,0.000009809075,0.000016683936,0.000004503995,0.000015888027,0.000020647427],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028848898,0.0004286871,0.00038957802,0.00031588922,0.00019025199,0.0003169248,0.0006084626,0.00024100381,0.0014769926],"category_scores_gemma":[0.00019786076,0.00022770197,0.00025705225,0.0002630108,0.00017936747,0.00028208678,0.00019922492,0.0005930555,0.00035759684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011165411,0.00067551737,0.00043268007,0.00035830846,0.00006476354,0.00067302305,0.000114910305,0.005082692,0.9552083,0.0020689429,0.0005228185,0.033681568],"study_design_scores_gemma":[0.0013634118,0.010741767,0.0026498293,0.00007254133,0.00024488958,0.0011444851,0.00008673686,0.0087129045,0.9464226,0.00052072,0.027968124,0.00007184267],"about_ca_topic_score_codex":0.000570686,"about_ca_topic_score_gemma":0.0023144237,"teacher_disagreement_score":0.0014769926,"about_ca_system_score_codex":0.0002802687,"about_ca_system_score_gemma":0.00048591904,"threshold_uncertainty_score":0.0049410462},"labels":[],"label_agreement":null},{"id":"W2058408394","doi":"10.1016/j.bmcl.2010.10.106","title":"A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Agonism; Antagonism; Pharmacology; Pharmacokinetics; Stereochemistry; Structure–activity relationship; Chemical synthesis; Receptor; Analgesic; In vivo; In vitro; Biochemistry; Medicine","score_opus":0.005792075459748085,"score_gpt":0.20642578174300635,"score_spread":0.20063370628325827,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2058408394","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.88812256,0.017257174,0.055191945,0.0013534231,0.0005439828,0.0005819954,0.0024483898,0.0010432021,0.033457316],"genre_scores_gemma":[0.9281453,0.011857478,0.027544947,0.0010680882,0.00012748419,0.00049410725,0.0018298097,0.00008331653,0.028849548],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989915,0.00001914343,0.000008864643,0.000017591896,0.00001831401,0.000036881174],"domain_scores_gemma":[0.99995744,0.000007369858,0.00000879831,0.0000059893323,0.000007248116,0.0000130974095],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021142383,0.00057086884,0.0003757444,0.00025786573,0.0002202432,0.00029545953,0.0006515929,0.00034010786,0.0043594483],"category_scores_gemma":[0.00018584562,0.00018990709,0.0001990937,0.00021508102,0.00019501348,0.00039957959,0.00044995942,0.0006888752,0.0011893021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089258637,0.0003459971,0.000283841,0.0004941709,0.000058078353,0.0006613192,0.0001132797,0.0014637074,0.9158295,0.003341579,0.003473995,0.0730419],"study_design_scores_gemma":[0.00033333883,0.003908456,0.0011406211,0.000034970857,0.00009335545,0.0014384129,0.000048631468,0.0022692638,0.935189,0.00066650636,0.054818768,0.000058680223],"about_ca_topic_score_codex":0.00027949963,"about_ca_topic_score_gemma":0.0007001587,"teacher_disagreement_score":0.0043594483,"about_ca_system_score_codex":0.00025507744,"about_ca_system_score_gemma":0.00024961063,"threshold_uncertainty_score":0.014583826},"labels":[],"label_agreement":null},{"id":"W2058514583","doi":"10.1016/j.bmcl.2012.12.016","title":"Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Chemistry; Cytotoxicity; Glutathione; Mitochondrion; Reactive oxygen species; Intracellular; Curcumin; Biochemistry; Thiol; Oxidative stress; In vitro; Enzyme","score_opus":0.013599054461986601,"score_gpt":0.21844388564037054,"score_spread":0.20484483117838392,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2058514583","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99636924,0.0016428384,0.0006899307,0.00009714344,0.000021639344,0.000009527965,0.00014664054,0.000042332234,0.0009807787],"genre_scores_gemma":[0.9979347,0.00082676066,0.0003675289,0.0000143850575,0.0000052890205,0.0000051329966,0.00014665749,0.0000030881608,0.00069655996],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995744,0.0000101084115,0.0000051417132,0.00000603701,0.000009108513,0.000012208722],"domain_scores_gemma":[0.9999275,0.000013248748,0.000020722955,0.000010149743,0.000012313065,0.000016071644],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008143238,0.00021712853,0.00016868974,0.00011949963,0.000130088,0.00011213204,0.00016438174,0.00018437258,0.0012097637],"category_scores_gemma":[0.00011049194,0.00010509431,0.00014538725,0.00009960571,0.000119435375,0.00012238866,0.00008633714,0.0004229169,0.00022611959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00062937493,0.00004119993,0.00032327173,0.000091831374,0.000006144848,0.00015817226,0.000027364938,0.0001808825,0.99601644,0.00008139596,0.000082413884,0.0023614012],"study_design_scores_gemma":[0.000035920057,0.0010495363,0.0061009936,0.000009619818,0.000028227985,0.00032449723,0.000030302814,0.00090236135,0.9902047,0.000038793165,0.0012698446,0.0000053737763],"about_ca_topic_score_codex":0.00084099517,"about_ca_topic_score_gemma":0.0010152304,"teacher_disagreement_score":0.0012097637,"about_ca_system_score_codex":0.00012471733,"about_ca_system_score_gemma":0.00015267571,"threshold_uncertainty_score":0.004047096},"labels":[],"label_agreement":null},{"id":"W2058986667","doi":"10.1016/j.bmcl.2013.04.077","title":"Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Respiratory viral infections research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Boehringer Ingelheim (Canada)","funders":"KU Leuven","keywords":"Rhinovirus; Chemistry; Chemical synthesis; Biological activity; Combinatorial chemistry; In vitro; Pharmacology; Virus; Virology; Biochemistry","score_opus":0.12649007700582754,"score_gpt":0.35936774329532795,"score_spread":0.2328776662895004,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2058986667","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9857519,0.004952726,0.005539621,0.00016431758,0.000060208164,0.00023516784,0.00027568577,0.000068732275,0.002951803],"genre_scores_gemma":[0.98811674,0.0031960616,0.0060511646,0.000060964292,0.000017158056,0.00007007791,0.0003010335,0.000010379354,0.0021763125],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999095,0.00001904702,0.000009508749,0.000012554602,0.000022837163,0.000026441321],"domain_scores_gemma":[0.9999405,0.000009272871,0.000015936943,0.0000058507867,0.000014751511,0.000013601683],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023743667,0.00027027578,0.00022074774,0.00021249757,0.00021622736,0.0002881654,0.0003655475,0.00033670748,0.0010113607],"category_scores_gemma":[0.00021672065,0.00014783663,0.00025965687,0.00017695509,0.00016238284,0.00018102619,0.0001345965,0.0003155461,0.00024225176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034312572,0.0001490337,0.00018107356,0.00015849402,0.000014510778,0.00023476723,0.000048322094,0.0011654001,0.98763406,0.00035048873,0.00012457091,0.009596255],"study_design_scores_gemma":[0.00021442209,0.0031372355,0.00096434343,0.000018318773,0.000048954902,0.0003553218,0.000035079975,0.0017594763,0.98689085,0.000068670946,0.006492226,0.000015048077],"about_ca_topic_score_codex":0.0007811937,"about_ca_topic_score_gemma":0.0018576788,"teacher_disagreement_score":0.0010113607,"about_ca_system_score_codex":0.00035437572,"about_ca_system_score_gemma":0.00034506744,"threshold_uncertainty_score":0.003383398},"labels":[],"label_agreement":null},{"id":"W2059355068","doi":"10.1016/j.bmcl.2007.03.016","title":"Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Indole test; Moiety; Linker; Conjugate; Estrogen receptor; Furan; Estrogen; Stereochemistry; Chemical synthesis; Ligand binding assay; Selective estrogen receptor modulator; Click chemistry; Combinatorial chemistry; In vitro; Receptor; Biochemistry; Organic chemistry","score_opus":0.004615967025262715,"score_gpt":0.20499878926298654,"score_spread":0.20038282223772383,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2059355068","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99591196,0.0006534212,0.002270317,0.000038547896,0.0000041372205,0.00001779231,0.00015221334,0.000011692064,0.00093989464],"genre_scores_gemma":[0.99385333,0.0004511121,0.002239345,0.000025544643,0.000003201867,0.000016376345,0.0004448626,0.000007641433,0.0029585643],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999589,0.000009778269,0.0000024140256,0.0000072514727,0.000009361641,0.000012236412],"domain_scores_gemma":[0.99994326,0.000016112534,0.000011511507,0.000008280238,0.00001152647,0.00000924905],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013111517,0.000120590754,0.00009835137,0.00010736339,0.00012048075,0.00008817015,0.000146358,0.0001256629,0.0010631623],"category_scores_gemma":[0.00015963953,0.00008856173,0.00010257286,0.00012718873,0.000071537615,0.00012162397,0.000057348152,0.00012244738,0.00019258195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018738321,0.0000295911,0.00025497974,0.00001670383,0.000006137072,0.000054877983,0.00003166078,0.00026170138,0.9956748,0.00017251474,0.000051291274,0.0032582514],"study_design_scores_gemma":[0.000016049558,0.00026749674,0.0017898108,0.0000015445511,0.000009240266,0.00010236313,0.000010992852,0.0004077337,0.99537224,0.000033068896,0.0019842058,0.000005194473],"about_ca_topic_score_codex":0.0009922486,"about_ca_topic_score_gemma":0.0014604847,"teacher_disagreement_score":0.0010631623,"about_ca_system_score_codex":0.00022896947,"about_ca_system_score_gemma":0.00014563423,"threshold_uncertainty_score":0.0035566688},"labels":[],"label_agreement":null},{"id":"W2059446431","doi":"10.1016/j.bmcl.2005.08.102","title":"Carbonic anhydrase inhibitors: Inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Isozyme; Carbonic anhydrase; Chemistry; Gene isoform; Cytosol; Enzyme; Stereochemistry; Enzyme inhibitor; Biochemistry; Sulfonamide; Gene","score_opus":0.00448855836320237,"score_gpt":0.18846192748266719,"score_spread":0.18397336911946482,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2059446431","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.933418,0.03390681,0.013218281,0.0007017518,0.00024036168,0.00029909448,0.0016807329,0.0006191757,0.015915768],"genre_scores_gemma":[0.9473719,0.02859162,0.0075088637,0.00042783874,0.00006983669,0.00017238357,0.0028190268,0.00003859747,0.01299999],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999899,0.000011536484,0.000008359101,0.00002394266,0.000030363268,0.000026750296],"domain_scores_gemma":[0.9999548,0.000008086561,0.000009270174,0.0000042350575,0.0000077226405,0.000015830847],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017745132,0.0007822049,0.0004670092,0.00047194006,0.00020439501,0.00021298094,0.0004453188,0.0002994744,0.0012573297],"category_scores_gemma":[0.00015289133,0.00022863374,0.00027903426,0.00035270618,0.00014517475,0.00021187385,0.000194333,0.0004900313,0.0004886341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000598251,0.00023554468,0.000434065,0.00021678294,0.00004755518,0.00032659672,0.000062261286,0.0016793013,0.94977903,0.00089428975,0.0017783619,0.04394802],"study_design_scores_gemma":[0.00034441976,0.0038050355,0.0036478227,0.00006862244,0.00015520611,0.0018176825,0.00003852587,0.0031142752,0.9462288,0.0002517546,0.04048484,0.00004299577],"about_ca_topic_score_codex":0.0009863973,"about_ca_topic_score_gemma":0.0031453378,"teacher_disagreement_score":0.0012573297,"about_ca_system_score_codex":0.0004916431,"about_ca_system_score_gemma":0.00031854148,"threshold_uncertainty_score":0.0042061806},"labels":[],"label_agreement":null},{"id":"W2059577406","doi":"10.1016/j.bmcl.2009.01.057","title":"Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"National Institutes of Health","keywords":"Chemistry; Moiety; Stereochemistry; Pyridazine; Tetrahydrofuran; Docking (animal); Structure–activity relationship; In vitro; Biochemistry","score_opus":0.008005259569593809,"score_gpt":0.22187760116760147,"score_spread":0.21387234159800766,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2059577406","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95679396,0.020438906,0.009856187,0.0006909931,0.00020663178,0.00033579956,0.0009142428,0.00024417677,0.010519023],"genre_scores_gemma":[0.96757007,0.016124174,0.010610939,0.00016367318,0.000041495296,0.00010054939,0.00073915464,0.000044241962,0.004605656],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982625,0.000041341667,0.00001843505,0.000027332499,0.000040029918,0.000046603083],"domain_scores_gemma":[0.9999125,0.00001580179,0.00002373596,0.000006613868,0.00001866126,0.00002266738],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041687343,0.0005070594,0.00065078086,0.00044272188,0.00025119062,0.00038964135,0.0006149342,0.00030547736,0.00320687],"category_scores_gemma":[0.00030609974,0.00024255847,0.00036403385,0.00049397163,0.00027832057,0.00034369642,0.00031368193,0.0005085192,0.0004721048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0030258417,0.0009131497,0.0009888768,0.0011882489,0.0001641571,0.0010911734,0.0002454762,0.018193476,0.9028604,0.0053286185,0.0016372458,0.06436332],"study_design_scores_gemma":[0.0020275353,0.016317261,0.0038218992,0.00018032285,0.0006160953,0.001502535,0.00024111207,0.016111849,0.905388,0.0010499207,0.052629005,0.00011445044],"about_ca_topic_score_codex":0.0013761818,"about_ca_topic_score_gemma":0.0042959256,"teacher_disagreement_score":0.00320687,"about_ca_system_score_codex":0.00048601284,"about_ca_system_score_gemma":0.00051913585,"threshold_uncertainty_score":0.010728061},"labels":[],"label_agreement":null},{"id":"W2059645874","doi":"10.1016/j.bmcl.2008.07.117","title":"Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; DNA gyrase; Side chain; Antibacterial activity; Topoisomerase; Topoisomerase IV; Antibacterial agent; Stereochemistry; Structure–activity relationship; Gram; Biochemistry; Antibiotics; DNA; Bacteria; In vitro; Escherichia coli; Organic chemistry; Gene; Genetics; Biology","score_opus":0.011016352030187132,"score_gpt":0.21171471377908316,"score_spread":0.20069836174889602,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2059645874","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.985187,0.0028607727,0.00415916,0.00013386674,0.000072047296,0.000069418886,0.00029024068,0.00014033128,0.0070872763],"genre_scores_gemma":[0.99448293,0.00089396775,0.002113785,0.000051901814,0.000012129672,0.000022811386,0.0002707061,0.000018211276,0.0021334314],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999045,0.00002127608,0.0000095987925,0.0000132655105,0.000016870601,0.00003433541],"domain_scores_gemma":[0.99992895,0.000012331744,0.000017290497,0.000008639227,0.000014460589,0.000018361561],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019116682,0.00031529408,0.00023487052,0.0001865316,0.00012843955,0.00014687807,0.00038490785,0.00028994377,0.0013863827],"category_scores_gemma":[0.0001589348,0.00009951912,0.00019387125,0.00010270579,0.00016448695,0.0001757129,0.00015263,0.00029489023,0.00044761784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006166781,0.00007445537,0.00022428558,0.00021310014,0.000016499318,0.00050700264,0.00009426027,0.0012172834,0.9845222,0.0013339487,0.0003188577,0.010861424],"study_design_scores_gemma":[0.000083197716,0.0012481271,0.00079069077,0.000016984663,0.000019113935,0.00032751678,0.000017858418,0.00097360194,0.9920859,0.00014039464,0.004277007,0.000019592642],"about_ca_topic_score_codex":0.0004830836,"about_ca_topic_score_gemma":0.00059885625,"teacher_disagreement_score":0.0013863827,"about_ca_system_score_codex":0.00023958815,"about_ca_system_score_gemma":0.00025222255,"threshold_uncertainty_score":0.004637897},"labels":[],"label_agreement":null},{"id":"W2060100865","doi":"10.1016/j.bmcl.2015.03.083","title":"The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; National Institute of Mental Health","keywords":"Neurotensin; Chemistry; Neurotensin receptor; Agonist; G protein-coupled receptor; Receptor; Antagonist; Linker; Calcium; Pharmacology; In vitro; Stereochemistry; Biochemistry; Neuropeptide; Medicine","score_opus":0.03744823921031787,"score_gpt":0.24996472331388128,"score_spread":0.2125164841035634,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2060100865","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98045635,0.0029393048,0.007359799,0.00039408557,0.0001770021,0.000028935057,0.00014205153,0.000060518665,0.008442124],"genre_scores_gemma":[0.99326986,0.0011181298,0.0017340773,0.0002055096,0.000053025986,0.000016812335,0.00016119836,0.000014786547,0.0034265271],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999366,0.000009860597,0.0000030408787,0.000013990457,0.000012446301,0.000024044151],"domain_scores_gemma":[0.99993217,0.00001985395,0.000016445696,0.0000040001814,0.0000065129607,0.000020922966],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046813,0.00022387182,0.0001355783,0.00005930212,0.00022685922,0.00021166223,0.00032887762,0.00029520525,0.00446845],"category_scores_gemma":[0.00019393725,0.00009343327,0.00010783711,0.00006050773,0.00018957382,0.0005462301,0.00024115873,0.0003531821,0.00081504555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00090231985,0.000031477553,0.0002645828,0.00009362574,0.000007468578,0.00045039598,0.00004897726,0.00037454013,0.9896437,0.0022600868,0.00022127201,0.0057017356],"study_design_scores_gemma":[0.00020651659,0.0010253782,0.0055744466,0.00004070557,0.000043507873,0.0013034102,0.0001409065,0.0024950162,0.97208124,0.0015702199,0.015488243,0.000030468986],"about_ca_topic_score_codex":0.00018738334,"about_ca_topic_score_gemma":0.00027563996,"teacher_disagreement_score":0.00446845,"about_ca_system_score_codex":0.00014893203,"about_ca_system_score_gemma":0.00018490477,"threshold_uncertainty_score":0.014948428},"labels":[],"label_agreement":null},{"id":"W2060190169","doi":"10.1016/j.bmcl.2009.11.052","title":"Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Stereochemistry; Ring (chemistry); Amine gas treating; Amyloid precursor protein secretase; Combinatorial chemistry; Structure–activity relationship; Enzyme inhibitor; Drug discovery; Enzyme; In vitro; Biochemistry; Amyloid precursor protein; Organic chemistry; Alzheimer's disease","score_opus":0.010056649801821645,"score_gpt":0.25947445869986213,"score_spread":0.2494178088980405,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2060190169","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97584844,0.0075794123,0.009412678,0.00027613787,0.00007015886,0.00027213068,0.00076862477,0.00012154708,0.005650815],"genre_scores_gemma":[0.9815702,0.005614678,0.008842099,0.000083352286,0.000020330583,0.000062259416,0.0007665262,0.000029873307,0.0030107277],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998479,0.00004231353,0.000014537455,0.000022898957,0.000042614014,0.000029688552],"domain_scores_gemma":[0.9999218,0.00001753949,0.000016441383,0.0000067757874,0.000018589211,0.00001880853],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000361951,0.0004712047,0.0005435774,0.0002999287,0.00021294723,0.00036112964,0.0005030008,0.00023196734,0.0015673678],"category_scores_gemma":[0.00034195345,0.00021340029,0.0002561886,0.000305459,0.00015170156,0.00022033896,0.00025377722,0.00047802855,0.00035869592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009926794,0.00055203866,0.0009688063,0.00034712587,0.00008523544,0.0006810715,0.00012961277,0.01117678,0.95278555,0.0019110331,0.00076070946,0.02960946],"study_design_scores_gemma":[0.0002956442,0.003205425,0.0015879064,0.0000304469,0.00013157408,0.00057667505,0.0000815844,0.008326626,0.9678601,0.0002592087,0.017619291,0.000025576783],"about_ca_topic_score_codex":0.0011061777,"about_ca_topic_score_gemma":0.0037236346,"teacher_disagreement_score":0.0015673678,"about_ca_system_score_codex":0.00047323978,"about_ca_system_score_gemma":0.00030321383,"threshold_uncertainty_score":0.005243361},"labels":[],"label_agreement":null},{"id":"W2060652239","doi":"10.1016/j.bmcl.2013.04.051","title":"A convenient synthesis of GDP-d-rhamnose: The donor substrate for d-rhamnosyltransferase WbpZ from Pseudomonas aeruginosa PAO1","year":2013,"lang":"en","type":"letter","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Rhamnose; Pseudomonas aeruginosa; Chemistry; Pseudomonadaceae; Pseudomonadales; Bacteria; Nucleotide sugar; Antigen; Substrate (aquarium); Biosynthesis; Biochemistry; Strain (injury); Enzyme; Polysaccharide; Microbiology; Stereochemistry; Biology","score_opus":0.014184227942371962,"score_gpt":0.20315190363985147,"score_spread":0.18896767569747952,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2060652239","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8271975,0.010532212,0.12612021,0.0077014756,0.0013862324,0.0007787563,0.0038166847,0.0011259039,0.021340964],"genre_scores_gemma":[0.9137329,0.009618387,0.062592275,0.0006284106,0.0002113003,0.0003252794,0.0026981402,0.00017629967,0.010017057],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976474,0.00004508639,0.000020569776,0.000037901642,0.00007169376,0.000059899583],"domain_scores_gemma":[0.9998696,0.000028394003,0.000020531206,0.000027618484,0.000022340078,0.00003159163],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028987273,0.0006984171,0.000510754,0.0001919901,0.00031633978,0.00035478474,0.0004995876,0.0008611128,0.0009780462],"category_scores_gemma":[0.00035741605,0.00025918346,0.00025921408,0.00037370156,0.0002959571,0.0003595232,0.00045468615,0.0013301763,0.0013960738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010032792,0.000049269267,0.00014161112,0.00022591939,0.000010998326,0.0011809714,0.00007801477,0.00037366553,0.98385924,0.001326294,0.0011658478,0.01148791],"study_design_scores_gemma":[0.00006213094,0.00025284896,0.00053778826,0.000011032808,0.000023185505,0.0009618543,0.000045963636,0.0009262376,0.97226936,0.00063452264,0.024244715,0.000030308025],"about_ca_topic_score_codex":0.0010741528,"about_ca_topic_score_gemma":0.0017351238,"teacher_disagreement_score":0.0010741528,"about_ca_system_score_codex":0.00067116367,"about_ca_system_score_gemma":0.0007328874,"threshold_uncertainty_score":0.00486964},"labels":[],"label_agreement":null},{"id":"W2060654442","doi":"10.1016/j.bmcl.2006.12.110","title":"Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Amination; Palladium; Apoptosis; Caspase; Catalysis; Solid-phase synthesis; Combinatorial chemistry; Protease; Chemical synthesis; Programmed cell death; Stereochemistry; Enzyme; Biochemistry; In vitro; Peptide","score_opus":0.010884420106332,"score_gpt":0.284543689546226,"score_spread":0.273659269439894,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2060654442","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9272111,0.0058759293,0.039537616,0.00044308772,0.0003166134,0.00031780257,0.0010954735,0.0005785681,0.02462381],"genre_scores_gemma":[0.98553467,0.0019676206,0.008725803,0.00004210147,0.000023715776,0.000048223792,0.00031126672,0.000030748884,0.0033158557],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998728,0.000027519556,0.0000107822925,0.000020167368,0.000032729753,0.00003596028],"domain_scores_gemma":[0.9999453,0.000011920054,0.000016353431,0.000009121493,0.00000602833,0.000011232904],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016745893,0.00042299915,0.00028353362,0.00018788608,0.00015367211,0.00026494067,0.00054798805,0.00021817237,0.002476334],"category_scores_gemma":[0.00013888752,0.000221279,0.00021550883,0.00018295652,0.00021002903,0.00027613237,0.00029317712,0.0006399165,0.00066214567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005468631,0.00015036858,0.00006893882,0.00032033565,0.000024289235,0.00046478465,0.00009015959,0.0021189386,0.9813913,0.002067703,0.00052823965,0.01222808],"study_design_scores_gemma":[0.00015479191,0.001044712,0.00021491243,0.000008458645,0.000017735552,0.0002544517,0.000014301086,0.0014025421,0.9883753,0.00020595499,0.008294586,0.000012191524],"about_ca_topic_score_codex":0.00022801613,"about_ca_topic_score_gemma":0.0006347011,"teacher_disagreement_score":0.002476334,"about_ca_system_score_codex":0.00024908595,"about_ca_system_score_gemma":0.00022666418,"threshold_uncertainty_score":0.008284152},"labels":[],"label_agreement":null},{"id":"W2060759328","doi":"10.1016/s0960-894x(01)00735-1","title":"5-Bromo (or chloro)-6-azido-5,6-dihydro-2′-deoxyuridine and -thymidine derivatives with potent antiviral activity","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; National Institute for Health and Care Research","keywords":"Chemistry; Thymidine; Deoxyuridine; Stereochemistry; Chemical synthesis; In vitro; Biochemistry; DNA","score_opus":0.015924413564988058,"score_gpt":0.19966130123925652,"score_spread":0.18373688767426846,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2060759328","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9579198,0.024198992,0.0058546015,0.00017619072,0.0001789602,0.00012120097,0.0006311841,0.0001461578,0.0107729435],"genre_scores_gemma":[0.98423314,0.0054608635,0.0049537043,0.00011312603,0.000061032264,0.000072160015,0.0007435512,0.00002018605,0.0043422896],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980265,0.000046381312,0.000016150696,0.000027140604,0.00005047923,0.00005706784],"domain_scores_gemma":[0.99984205,0.000032858028,0.000028188497,0.000020929061,0.00001994857,0.00005605952],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034250124,0.00030976353,0.00057788705,0.00030114473,0.00019924124,0.00026580165,0.00048606843,0.00034136046,0.0017532654],"category_scores_gemma":[0.00026313768,0.00021459904,0.000266974,0.00027337403,0.000264289,0.00019665179,0.00023750933,0.00045934666,0.000501745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005247726,0.000082096696,0.00023068412,0.00012971295,0.000015913241,0.00015492659,0.000043513537,0.00027621258,0.9896806,0.00046196507,0.00012720976,0.008272375],"study_design_scores_gemma":[0.00016716273,0.0027332217,0.0031306911,0.000016684999,0.000055763514,0.00090013247,0.000025716456,0.0005643908,0.9810315,0.00008955678,0.011268741,0.00001638227],"about_ca_topic_score_codex":0.00038993492,"about_ca_topic_score_gemma":0.0009171452,"teacher_disagreement_score":0.0017532654,"about_ca_system_score_codex":0.00023886215,"about_ca_system_score_gemma":0.00024488498,"threshold_uncertainty_score":0.005865276},"labels":[],"label_agreement":null},{"id":"W2061010495","doi":"10.1016/j.bmcl.2011.06.034","title":"Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph","funders":"Ministry of Science and Technology; Ministerio de Ciencia e Innovación; National Natural Science Foundation of China; Canadian Cancer Society; Comunidad de Madrid","keywords":"Chemistry; Microtubule; Taxane; Cytotoxicity; Paclitaxel; P-glycoprotein; Affinities; Drug; Binding site; In vitro; Plasma protein binding; Stereochemistry; Biochemistry; Structure–activity relationship; Multiple drug resistance; Pharmacology; Cell biology; Cancer","score_opus":0.01337976189394388,"score_gpt":0.23701707771642486,"score_spread":0.22363731582248098,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061010495","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99795437,0.00033998865,0.00023866411,0.00009204541,0.000054315187,0.000015749893,0.00020429332,0.00003192748,0.0010687123],"genre_scores_gemma":[0.9981407,0.00022371246,0.0003099968,0.000059551465,0.000015031602,0.000008525063,0.00024118161,0.00003895712,0.00096241076],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99956554,0.00012668702,0.000064750835,0.000053367068,0.00008215247,0.000107598506],"domain_scores_gemma":[0.9994599,0.00022682945,0.00008097979,0.00004702546,0.00008345225,0.000101784455],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003305404,0.0004003929,0.0004642029,0.00026526494,0.00038903306,0.00039291204,0.0006268979,0.0007965811,0.006351188],"category_scores_gemma":[0.00065609737,0.00024389352,0.0003935371,0.00027145364,0.00054221676,0.00035189185,0.0002612344,0.0008472363,0.0010296789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.005682783,0.0004800648,0.0005428319,0.000056611945,0.00010053228,0.00048120154,0.000050464918,0.0014152003,0.98610395,0.000534161,0.0003263452,0.00422595],"study_design_scores_gemma":[0.00026474058,0.0019922797,0.0018606836,0.000013076876,0.00010547911,0.0004564994,0.000052802992,0.00336696,0.9896938,0.00011213446,0.002048697,0.000032834432],"about_ca_topic_score_codex":0.0049565504,"about_ca_topic_score_gemma":0.003535658,"teacher_disagreement_score":0.006351188,"about_ca_system_score_codex":0.00050521595,"about_ca_system_score_gemma":0.000539071,"threshold_uncertainty_score":0.02124691},"labels":[],"label_agreement":null},{"id":"W2061188620","doi":"10.1016/j.bmcl.2010.09.084","title":"Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Achaogen","keywords":"Aminoglycoside; Chemistry; Antibiotics; Amphiphile; Bacteria; Stereochemistry; Biophysics; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.009154533246312145,"score_gpt":0.21595949459028124,"score_spread":0.20680496134396908,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061188620","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98855525,0.0008223386,0.008263458,0.00021327878,0.00003300834,0.000093401024,0.00016049841,0.00014673345,0.0017120346],"genre_scores_gemma":[0.9774918,0.00075971585,0.019356582,0.000059013535,0.000011435726,0.00009352907,0.00030850837,0.00006074178,0.0018587267],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987245,0.000025261688,0.00001486719,0.000021463826,0.000043862852,0.000022039458],"domain_scores_gemma":[0.99990284,0.000025711775,0.000021007043,0.000012005349,0.000016755705,0.000021646076],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020584032,0.00023776536,0.0003547399,0.00012172746,0.00029678896,0.0006069584,0.0003985294,0.00033926443,0.00088564324],"category_scores_gemma":[0.00035931863,0.00032040273,0.00019460928,0.00013573807,0.00018022241,0.00024700127,0.00019919794,0.00071179995,0.00041078022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014108555,0.00012513298,0.0001691274,0.0000730367,0.000010071776,0.00004122345,0.000033094926,0.0035175164,0.9907817,0.00071160286,0.00022157801,0.004174761],"study_design_scores_gemma":[0.000056268273,0.00011206002,0.00017988186,0.0000033807712,0.000009595533,0.000047662583,0.000016491489,0.007964705,0.98959154,0.00004326743,0.001969254,0.000005966975],"about_ca_topic_score_codex":0.00070031796,"about_ca_topic_score_gemma":0.0014016145,"teacher_disagreement_score":0.00088564324,"about_ca_system_score_codex":0.000657686,"about_ca_system_score_gemma":0.00043910914,"threshold_uncertainty_score":0.0047718883},"labels":[],"label_agreement":null},{"id":"W2061270204","doi":"10.1016/j.bmcl.2010.09.094","title":"2-Aryl benzimidazoles: Human SCD1-specific stearoyl coenzyme-A desaturase inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Benzimidazole; Aryl; Enzyme; Selectivity; Coenzyme A; Gene isoform; Biochemistry; Structure–activity relationship; Chemical synthesis; Stearoyl-CoA Desaturase; In vitro; Pharmacology; Gene expression; Gene; Reductase; Organic chemistry","score_opus":0.007762727452450942,"score_gpt":0.22734651781302362,"score_spread":0.21958379036057268,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061270204","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8977457,0.062441725,0.012410044,0.002253003,0.0008958848,0.00043154214,0.0023317358,0.0009052868,0.020585153],"genre_scores_gemma":[0.96842456,0.015633611,0.0037738653,0.00038639014,0.00009912509,0.00015114613,0.0019166621,0.000024593302,0.00959004],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988604,0.000026618536,0.0000059506015,0.000016631517,0.000025274803,0.000039514114],"domain_scores_gemma":[0.99995744,0.000008013971,0.000008034181,0.0000044884987,0.000010013738,0.0000120570885],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278779,0.00035286695,0.00030322827,0.0002444695,0.00019844098,0.00024500667,0.00029240164,0.000287033,0.0020242292],"category_scores_gemma":[0.00017236895,0.00010304079,0.00015445097,0.00027424045,0.00013477026,0.00012229418,0.0001677407,0.0005807486,0.00071615155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.004362812,0.00052699907,0.0014811098,0.00031695893,0.000072432566,0.00060997804,0.00010491573,0.0013872109,0.8980144,0.002288646,0.0074915574,0.08334291],"study_design_scores_gemma":[0.0018931668,0.004632437,0.007669812,0.000052099338,0.00017202483,0.002319811,0.00006534783,0.0032714433,0.83448476,0.00035403194,0.14504467,0.00004044265],"about_ca_topic_score_codex":0.0025968268,"about_ca_topic_score_gemma":0.008864076,"teacher_disagreement_score":0.0025968268,"about_ca_system_score_codex":0.00075273245,"about_ca_system_score_gemma":0.00038808165,"threshold_uncertainty_score":0.0067717433},"labels":[],"label_agreement":null},{"id":"W2061312813","doi":"10.1016/j.bmcl.2010.03.109","title":"Clinical status of duplex RNA","year":2010,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"RNA; Duplex (building); In vivo; Computational biology; Chemistry; Gene; Genetics; Biology; Biochemistry; DNA","score_opus":0.014864721901972019,"score_gpt":0.28660506959699983,"score_spread":0.2717403476950278,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061312813","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.047378853,0.7918739,0.010330783,0.036345113,0.006596006,0.00021303858,0.0008782191,0.000511933,0.1058722],"genre_scores_gemma":[0.5374137,0.31922692,0.011467131,0.046833023,0.011951287,0.00057161815,0.0031983468,0.0002503836,0.06908759],"study_design_codex":"design_other","study_design_gemma":"observational","domain_scores_codex":[0.99950504,0.0001619404,0.00006531998,0.00010899343,0.00010128213,0.00005748855],"domain_scores_gemma":[0.9989141,0.0005821298,0.00010733167,0.00008042727,0.00017886198,0.00013722105],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015676229,0.0003869894,0.0004641429,0.00066353293,0.00034387945,0.0015495672,0.0005204818,0.0012845742,0.0062481593],"category_scores_gemma":[0.0025455046,0.00015084445,0.00023215098,0.0005139009,0.000900696,0.0011045481,0.00041716362,0.0012252604,0.002861682],"study_design_candidate":"observational","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024991147,0.0002599175,0.0024418214,0.0013699975,0.00005597685,0.0020940574,0.00011434074,0.0002755285,0.029089944,0.017173212,0.034126274,0.9104998],"study_design_scores_gemma":[0.0006319606,0.0042448104,0.0058204643,0.0009955975,0.00018326059,0.014354533,0.000078858044,0.0009617124,0.035394527,0.010841906,0.9264321,0.000060308106],"about_ca_topic_score_codex":0.00031410807,"about_ca_topic_score_gemma":0.0003668537,"teacher_disagreement_score":0.0062481593,"about_ca_system_score_codex":0.0010719738,"about_ca_system_score_gemma":0.0012930495,"threshold_uncertainty_score":0.020902157},"labels":[],"label_agreement":null},{"id":"W2061480585","doi":"10.1016/j.bmcl.2010.10.039","title":"Synthesis of d- and l-tyrosine-chlorambucil analogs active against breast cancer cell lines","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chlorambucil; Chemistry; Moiety; Tyrosine; Stereochemistry; Biological activity; In vitro; Cell culture; Breast cancer; Cancer research; Cancer; Cancer cell lines; Cancer cell; Chemotherapy; Biochemistry; Internal medicine; Biology; Medicine","score_opus":0.004271944624688346,"score_gpt":0.21135809988090049,"score_spread":0.20708615525621213,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061480585","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9720777,0.0054617943,0.008579913,0.0002751438,0.0001255373,0.00049112615,0.0017539389,0.0002529448,0.010981942],"genre_scores_gemma":[0.9899698,0.0021793833,0.004503876,0.00010595885,0.000017788185,0.00014097315,0.0010108441,0.000019442376,0.0020519437],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999361,0.000011489775,0.000007674833,0.000010235018,0.0000109526045,0.000023514838],"domain_scores_gemma":[0.9999348,0.0000110318415,0.000013068305,0.000009647484,0.000009632784,0.000021755544],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114494294,0.00031094204,0.0003259513,0.0002061424,0.00017976282,0.00017081674,0.00035729137,0.00022556211,0.001793914],"category_scores_gemma":[0.00012368802,0.00016308576,0.00018776466,0.0002307079,0.00010739861,0.00014145114,0.00016809997,0.00036953168,0.00037852948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042446525,0.00008745918,0.00010743708,0.00014901445,0.000013085732,0.00019678127,0.000033824028,0.000697726,0.9878889,0.00032699734,0.00029334222,0.009781147],"study_design_scores_gemma":[0.00021562437,0.0011271349,0.0009247447,0.000010727261,0.00003357681,0.0003335317,0.000016830802,0.00058546773,0.9877571,0.000057866007,0.008926892,0.00001052065],"about_ca_topic_score_codex":0.00074885215,"about_ca_topic_score_gemma":0.0011660091,"teacher_disagreement_score":0.001793914,"about_ca_system_score_codex":0.00025819862,"about_ca_system_score_gemma":0.00027205367,"threshold_uncertainty_score":0.006001234},"labels":[],"label_agreement":null},{"id":"W2061612860","doi":"10.1016/j.bmcl.2013.05.046","title":"Discovery of novel P2 substituted 4-biaryl proline inhibitors of hepatitis C virus NS3 serine protease","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Enzyme; Serine; NS3; Serine protease; Hepatitis C virus; Stereochemistry; Thiazole; Catalytic triad; Structure–activity relationship; Moiety; Serine Proteinase Inhibitors; Protease; Biochemistry; Combinatorial chemistry; Virus; In vitro; Virology; Biology","score_opus":0.01758841830503546,"score_gpt":0.2595481528196002,"score_spread":0.24195973451456473,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061612860","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9640069,0.0090126125,0.013188517,0.00044323763,0.00019281633,0.0003791552,0.0007753055,0.00033429902,0.011667164],"genre_scores_gemma":[0.98431164,0.0041829944,0.0055489684,0.0002166172,0.000034407632,0.000087357985,0.00067051017,0.000021613958,0.004925865],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993396,0.000011330188,0.0000052507075,0.00001024146,0.00001536339,0.000023794784],"domain_scores_gemma":[0.9999691,0.0000031625902,0.000008877632,0.0000026687947,0.0000059011977,0.00001028067],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017466504,0.0004762568,0.00029749548,0.0002074111,0.00016971082,0.0002784047,0.00041964152,0.0003039904,0.001316882],"category_scores_gemma":[0.00010773156,0.00017671987,0.00024455623,0.00016032996,0.00011383046,0.00023231507,0.00020495607,0.0005247394,0.00038747353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080860406,0.0002249193,0.0002881075,0.0002259394,0.000056864003,0.0007586901,0.000053319945,0.000947288,0.9680056,0.000905724,0.00083036267,0.026894465],"study_design_scores_gemma":[0.0008047212,0.00433727,0.002338269,0.000029010063,0.00012721638,0.0016253225,0.000039463655,0.00486956,0.96542203,0.00025312934,0.020118013,0.000036024157],"about_ca_topic_score_codex":0.00048245295,"about_ca_topic_score_gemma":0.001225756,"teacher_disagreement_score":0.001316882,"about_ca_system_score_codex":0.0002592791,"about_ca_system_score_gemma":0.00018243547,"threshold_uncertainty_score":0.0044053793},"labels":[],"label_agreement":null},{"id":"W2061998059","doi":"10.1016/j.bmcl.2009.05.020","title":"Synthesis and activity of quinolinylmethyl P1′ α-sulfone piperidine hydroxamate inhibitors of TACE","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Piperidine; Sulfone; Chemistry; Enzyme; Stereochemistry; Enzyme inhibitor; Chemical synthesis; Organic chemistry; In vitro; Biochemistry","score_opus":0.006178394194108985,"score_gpt":0.21309322198977954,"score_spread":0.20691482779567055,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2061998059","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9646711,0.0074751223,0.014812563,0.0003561007,0.00014582093,0.00031880487,0.00084904965,0.00036613017,0.011005247],"genre_scores_gemma":[0.9878414,0.003134293,0.00340395,0.00008778069,0.000033192704,0.00007651608,0.0006798628,0.000022683562,0.004720295],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998963,0.0000172611,0.000012385768,0.000014517459,0.000021786993,0.000037714042],"domain_scores_gemma":[0.99992704,0.000011543333,0.000018574141,0.000009761764,0.000012433656,0.000020677759],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024759874,0.0004007631,0.00032682158,0.00024188618,0.000167469,0.00020189521,0.0004201843,0.00019773327,0.0019777648],"category_scores_gemma":[0.00015729836,0.00019066877,0.0001828578,0.00016124787,0.00013877885,0.00024340802,0.0001621942,0.0004993168,0.00045622693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003811552,0.00013411226,0.000110420035,0.00012493676,0.00002023109,0.00024298375,0.00004537,0.00056411,0.9852014,0.00056523277,0.0004095765,0.012200549],"study_design_scores_gemma":[0.00016365046,0.0016182127,0.0010380123,0.000010792941,0.000041276657,0.00039240468,0.000015127047,0.0011626267,0.98783666,0.00005940439,0.00764826,0.0000135454],"about_ca_topic_score_codex":0.00047170062,"about_ca_topic_score_gemma":0.0009315494,"teacher_disagreement_score":0.0019777648,"about_ca_system_score_codex":0.00022254807,"about_ca_system_score_gemma":0.00018413433,"threshold_uncertainty_score":0.0066162944},"labels":[],"label_agreement":null},{"id":"W2062039886","doi":"10.1016/j.bmcl.2008.03.015","title":"Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Receptor; Antagonist; Prostaglandin D2; Pharmacology; Potency; In vitro; Biochemistry; Biology","score_opus":0.00907403690753117,"score_gpt":0.2261593831376646,"score_spread":0.21708534623013342,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062039886","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9420601,0.008778578,0.03212736,0.00072977965,0.00021725553,0.00036139155,0.000695943,0.0005509383,0.014478661],"genre_scores_gemma":[0.9729006,0.0031995862,0.016603367,0.00025888698,0.000059975937,0.0001440552,0.0009142514,0.000030483037,0.0058886814],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993587,0.00001272668,0.0000040744003,0.000011079363,0.000015363346,0.0000208773],"domain_scores_gemma":[0.99995387,0.000007813561,0.000010598882,0.000004440965,0.000008643003,0.000014614844],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013354182,0.0003079497,0.00043725502,0.00026051584,0.00019930206,0.0003759058,0.00053986796,0.00039349683,0.0018263289],"category_scores_gemma":[0.00013487825,0.00017895407,0.00027304425,0.00014078895,0.00014237252,0.00020949684,0.00020541252,0.00059051334,0.0006866113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004577005,0.00012992429,0.00013376899,0.00009579898,0.000015410604,0.0004506827,0.00004014195,0.0006186097,0.98097,0.000912083,0.00047001534,0.015705923],"study_design_scores_gemma":[0.0003896704,0.004783913,0.0018135345,0.000027555378,0.00009035146,0.0015648904,0.000050181614,0.005180122,0.9639812,0.00040679704,0.021663975,0.000047808437],"about_ca_topic_score_codex":0.0003516043,"about_ca_topic_score_gemma":0.0008878561,"teacher_disagreement_score":0.0018263289,"about_ca_system_score_codex":0.00027503434,"about_ca_system_score_gemma":0.00027053023,"threshold_uncertainty_score":0.006109655},"labels":[],"label_agreement":null},{"id":"W2062343060","doi":"10.1016/j.bmcl.2008.09.008","title":"Eicosapentaenoic-acid-derived isoprostanes: Synthesis and discovery of two major isoprostanes","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Christie (Canada)","funders":"National Heart, Lung, and Blood Institute","keywords":"Isoprostanes; Chemistry; Eicosapentaenoic acid; Isoprostane; Biochemistry; Oxidative stress; Fatty acid; Polyunsaturated fatty acid; Lipid peroxidation","score_opus":0.015309003310605257,"score_gpt":0.23996405232373635,"score_spread":0.2246550490131311,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062343060","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.740788,0.06628213,0.17260098,0.0046146326,0.0016681361,0.0008041543,0.0017867669,0.00030307483,0.01115216],"genre_scores_gemma":[0.82136357,0.03073053,0.12084499,0.0015591563,0.00043321936,0.0004329055,0.002681486,0.000068717396,0.021885496],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982435,0.000025187634,0.00001607593,0.000042645617,0.000046873505,0.000044866283],"domain_scores_gemma":[0.99978775,0.000019801317,0.000027659606,0.000024251503,0.00006576556,0.00007471613],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00049196143,0.00058276084,0.00039244466,0.0005827331,0.00028953134,0.0004723546,0.0003569249,0.00072998944,0.0012954823],"category_scores_gemma":[0.0003488842,0.0002241029,0.00046868893,0.00037052805,0.00030466702,0.0007342663,0.0005345853,0.0012058865,0.0006710265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00086972205,0.00023654723,0.0004334192,0.00022362718,0.000025311452,0.00032154532,0.00006942429,0.00018539786,0.9600355,0.0025921324,0.00035672614,0.03465066],"study_design_scores_gemma":[0.00014523066,0.0006723844,0.0012108084,0.000021908321,0.000033520228,0.00056413386,0.000039206123,0.0003357857,0.98125654,0.0009257148,0.014778082,0.000016540424],"about_ca_topic_score_codex":0.00026133878,"about_ca_topic_score_gemma":0.00046131705,"teacher_disagreement_score":0.0012954823,"about_ca_system_score_codex":0.0004473562,"about_ca_system_score_gemma":0.00088253827,"threshold_uncertainty_score":0.004333794},"labels":[],"label_agreement":null},{"id":"W2062441195","doi":"10.1016/j.bmcl.2012.03.071","title":"Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Seventh Framework Programme; Canadian Thoracic Society","keywords":"Chemistry; Flavones; Carbonic anhydrase; Stereochemistry; Enzyme; Carbonic Anhydrase I; Coumarin; Active site; Sulfonamide; Thio-; Enzyme inhibitor; Mechanism of action; Structure–activity relationship; Hydrolysis; Biochemistry; Organic chemistry; In vitro","score_opus":0.008946023556571932,"score_gpt":0.22358809134803823,"score_spread":0.2146420677914663,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062441195","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9758246,0.012695819,0.004798413,0.0004626655,0.000137966,0.00010001407,0.0002526123,0.00007646657,0.0056514423],"genre_scores_gemma":[0.9901147,0.0029751235,0.0021220113,0.00017866476,0.000031420597,0.000028183917,0.00020029265,0.0000075246717,0.0043421667],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993086,0.000014591277,0.0000040005007,0.000012914389,0.000015594807,0.000021951992],"domain_scores_gemma":[0.9999192,0.000028157032,0.000016067876,0.000012738417,0.000010670747,0.000013058743],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017332437,0.00025304174,0.00022984373,0.0001898307,0.00012828018,0.00028267124,0.00027587684,0.00041900954,0.0015134455],"category_scores_gemma":[0.00013452901,0.00010244931,0.00035138885,0.00009192698,0.00026269627,0.00033100712,0.0000942376,0.00048525084,0.00024581412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002455556,0.00004228289,0.00017789268,0.000057025336,0.000021656888,0.000058709797,0.000015402635,0.00015637248,0.99453026,0.0011806886,0.00006208192,0.0034521085],"study_design_scores_gemma":[0.00018475944,0.0016273676,0.007391263,0.000009991906,0.000048198897,0.00035748302,0.000028145152,0.00070397585,0.982474,0.0004479136,0.006710111,0.000016650913],"about_ca_topic_score_codex":0.00085022213,"about_ca_topic_score_gemma":0.001859248,"teacher_disagreement_score":0.0015134455,"about_ca_system_score_codex":0.00028013112,"about_ca_system_score_gemma":0.00021346948,"threshold_uncertainty_score":0.0050629973},"labels":[],"label_agreement":null},{"id":"W2062583481","doi":"10.1016/j.bmcl.2010.07.133","title":"Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone health and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; University of Oxford","keywords":"Farnesyl pyrophosphate; Chemistry; Pyrophosphate; Bisphosphonate; Farnesyl diphosphate synthase; Isopentenyl pyrophosphate; Enzyme; Stereochemistry; ATP synthase; Substrate specificity; Biochemistry; Substrate (aquarium)","score_opus":0.010464767827819195,"score_gpt":0.25104603768931916,"score_spread":0.24058126986149997,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062583481","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9243843,0.03538305,0.01392286,0.0010254639,0.0006862322,0.00039468362,0.001125964,0.0006365993,0.022440925],"genre_scores_gemma":[0.96257377,0.0191327,0.004347232,0.00037286847,0.000090114634,0.0001402632,0.0016155641,0.000033522785,0.011694109],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999194,0.00001282499,0.0000074877807,0.000012570673,0.000018322553,0.00002929405],"domain_scores_gemma":[0.9999671,0.000008609306,0.0000069160365,0.0000030858596,0.0000041633707,0.000010128292],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020615969,0.0005940908,0.00041809963,0.00029518668,0.00016481396,0.00043875416,0.0004483064,0.00033403264,0.0023733217],"category_scores_gemma":[0.00014491363,0.00020750586,0.00026247246,0.00018786118,0.00017038193,0.0001821447,0.00020912521,0.00078951713,0.0005805477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002706729,0.0007998814,0.0005033097,0.00037253677,0.00013299673,0.0006903311,0.0000871912,0.0026031788,0.90868634,0.004776508,0.0023580666,0.07628293],"study_design_scores_gemma":[0.0022802092,0.005227531,0.002603486,0.00006805153,0.00022808877,0.0025334908,0.00006785251,0.0065170815,0.92123,0.001214837,0.057968218,0.000061206985],"about_ca_topic_score_codex":0.0008658131,"about_ca_topic_score_gemma":0.002082631,"teacher_disagreement_score":0.0023733217,"about_ca_system_score_codex":0.00048119063,"about_ca_system_score_gemma":0.00034852154,"threshold_uncertainty_score":0.0079395175},"labels":[],"label_agreement":null},{"id":"W2062627259","doi":"10.1016/j.bmcl.2011.05.014","title":"Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Renin–angiotensin system; Renin inhibitor; Series (stratigraphy); Combinatorial chemistry; Stereochemistry; Enzyme inhibitor; Enzyme; Biochemistry; Internal medicine","score_opus":0.07261663942099733,"score_gpt":0.24459700858783248,"score_spread":0.17198036916683515,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062627259","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9478844,0.020108044,0.022729676,0.0004399776,0.00017201064,0.00043292282,0.00048786917,0.00030110197,0.007444131],"genre_scores_gemma":[0.95452607,0.014542711,0.025102433,0.000307047,0.000075565404,0.0001312129,0.00049823965,0.000038124002,0.0047786096],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992514,0.0000155527,0.000008309801,0.000014676716,0.000017356846,0.000018878518],"domain_scores_gemma":[0.99992657,0.000010848877,0.00002468523,0.0000050397334,0.000010930086,0.000021898828],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029906497,0.0004426822,0.00035417205,0.00017847405,0.00014224631,0.00019494692,0.0004024384,0.00017084867,0.0020533078],"category_scores_gemma":[0.00018261196,0.00017817528,0.00021067105,0.0001430105,0.00014613585,0.00034775253,0.00018867292,0.0006061523,0.00033932007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009515411,0.00046097543,0.00039017684,0.00061129575,0.000041436226,0.0004017378,0.00010968942,0.0030377689,0.9352523,0.0013574106,0.00054947846,0.05683615],"study_design_scores_gemma":[0.0011745114,0.014063055,0.0035066174,0.00011612958,0.00023106954,0.0014119982,0.0000718673,0.008572848,0.93302876,0.00038198612,0.037366703,0.00007440894],"about_ca_topic_score_codex":0.00032673622,"about_ca_topic_score_gemma":0.0014497718,"teacher_disagreement_score":0.0020533078,"about_ca_system_score_codex":0.00020252742,"about_ca_system_score_gemma":0.00023675419,"threshold_uncertainty_score":0.006869018},"labels":[],"label_agreement":null},{"id":"W2062727936","doi":"10.1016/j.bmcl.2006.01.095","title":"Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Fluorescence; Glycoside hydrolase; Alkylation; Stereochemistry; Combinatorial chemistry; Biochemistry; Enzyme","score_opus":0.006814560627763337,"score_gpt":0.18911801292483107,"score_spread":0.18230345229706774,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062727936","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9163571,0.0040714717,0.058194585,0.00085941574,0.00037883938,0.00016831011,0.0010072695,0.0014631902,0.017499711],"genre_scores_gemma":[0.9754701,0.0017861254,0.015039151,0.00011988009,0.00005691179,0.00010445183,0.0009964374,0.00009228177,0.0063345875],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997094,0.000049244005,0.000015727444,0.000059957132,0.00005133553,0.00011422428],"domain_scores_gemma":[0.99977344,0.00006387842,0.000042498752,0.00004040358,0.000025523954,0.000054235097],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004352626,0.00087126397,0.00041721572,0.00038502214,0.00024196069,0.00048982096,0.00068142754,0.0005313172,0.0018060034],"category_scores_gemma":[0.00034729598,0.00029507358,0.00024123694,0.00030867866,0.00041459818,0.00043261956,0.00030367787,0.0011697175,0.0006413296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027035322,0.00004844693,0.00009345608,0.000075801865,0.000008031772,0.00012727067,0.00004275933,0.00043215964,0.992784,0.0020480212,0.00029864075,0.0037711593],"study_design_scores_gemma":[0.000010135227,0.00007355593,0.00006677338,0.0000014071885,0.0000042819956,0.000036306337,0.0000050290328,0.0003481535,0.997912,0.000040222923,0.0014998578,0.0000023010498],"about_ca_topic_score_codex":0.00053351483,"about_ca_topic_score_gemma":0.0007119088,"teacher_disagreement_score":0.0018060034,"about_ca_system_score_codex":0.0010113625,"about_ca_system_score_gemma":0.0002935698,"threshold_uncertainty_score":0.007337928},"labels":[],"label_agreement":null},{"id":"W2062815640","doi":"10.1016/j.bmcl.2007.05.043","title":"Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Tripeptide; Peptidomimetic; Motilin; Stereochemistry; Chemical synthesis; Amino acid; Dipeptide; Oligopeptide; Combinatorial chemistry; Peptide; In vitro; Biochemistry","score_opus":0.007801313205575552,"score_gpt":0.2362906921839767,"score_spread":0.22848937897840113,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062815640","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96739274,0.006896528,0.015337101,0.00026563634,0.00024003505,0.0001725039,0.00037333474,0.0003589914,0.008963205],"genre_scores_gemma":[0.98374486,0.0037457824,0.0058333157,0.00024920295,0.000090228816,0.00011036136,0.00038870712,0.000057260288,0.0057803304],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990904,0.000019074387,0.0000070735,0.000016115886,0.000020429217,0.000028367353],"domain_scores_gemma":[0.9999387,0.000012289048,0.000015598023,0.0000050944386,0.000007366853,0.00002086866],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017412842,0.0004568029,0.00045765,0.00015791347,0.00017814351,0.00036604196,0.0003997367,0.00028700754,0.0015497982],"category_scores_gemma":[0.00016505837,0.00020468638,0.00013533482,0.000105531966,0.00019724427,0.00024535522,0.0002785093,0.0005365379,0.0006304423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00050988025,0.000045205874,0.00008340117,0.00006593789,0.000014705636,0.00020268005,0.000031127525,0.00057300046,0.9899614,0.0010686993,0.00025606307,0.0071879104],"study_design_scores_gemma":[0.00019605736,0.0024221814,0.0007513378,0.000012601845,0.000046187954,0.0007633185,0.000022305743,0.0019224794,0.9750131,0.00029285933,0.018528476,0.000029135766],"about_ca_topic_score_codex":0.00025855406,"about_ca_topic_score_gemma":0.00076285924,"teacher_disagreement_score":0.0015497982,"about_ca_system_score_codex":0.000234674,"about_ca_system_score_gemma":0.00014797103,"threshold_uncertainty_score":0.0051846504},"labels":[],"label_agreement":null},{"id":"W2062946333","doi":"10.1016/s0960-894x(01)00554-6","title":"Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Moiety; Chemistry; Aryl; Antagonist; Thio-; Stereochemistry; Potency; Chemical synthesis; Receptor; In vitro; Biochemistry; Organic chemistry; Alkyl","score_opus":0.005086343750077261,"score_gpt":0.2063965479467382,"score_spread":0.20131020419666093,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2062946333","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93087655,0.027436512,0.011704982,0.0011249896,0.0005133594,0.00028549813,0.0014426972,0.00035113556,0.026264315],"genre_scores_gemma":[0.9709801,0.013826894,0.0033038135,0.00016606954,0.00012154589,0.00012266214,0.0007965715,0.000025423229,0.01065691],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987674,0.000023458499,0.000014820198,0.00001016517,0.000023770403,0.00005111932],"domain_scores_gemma":[0.99991024,0.000014816314,0.000019185698,0.000009337423,0.000019502551,0.000026865466],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019745351,0.00036511006,0.00031749034,0.00035945847,0.0002913934,0.00020749892,0.00046832606,0.00024049883,0.0034247087],"category_scores_gemma":[0.00023220724,0.00018488379,0.0002605968,0.00036300908,0.00024030697,0.00021050037,0.0002697056,0.00041012265,0.0008551641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000753822,0.00015163403,0.00040756012,0.00050668075,0.000028350358,0.0008883201,0.00019059476,0.00086324057,0.97352433,0.0017244208,0.00087633467,0.020084817],"study_design_scores_gemma":[0.00025073605,0.0023172516,0.0043416866,0.000045078956,0.000079470316,0.0004882858,0.00008611453,0.00087519403,0.9660121,0.0002539589,0.025212476,0.000037673177],"about_ca_topic_score_codex":0.0015662459,"about_ca_topic_score_gemma":0.0024485816,"teacher_disagreement_score":0.0034247087,"about_ca_system_score_codex":0.00034143662,"about_ca_system_score_gemma":0.00054931524,"threshold_uncertainty_score":0.011456788},"labels":[],"label_agreement":null},{"id":"W2063472596","doi":"10.1016/j.bmcl.2005.01.062","title":"iPF2α-III-17,18,19,20-d4: Total synthesis and metabolism","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Chemistry; Chemical synthesis; Total synthesis; Metabolism; Stereochemistry; In vitro; Biochemistry","score_opus":0.01623009003626236,"score_gpt":0.2641730819518581,"score_spread":0.24794299191559577,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063472596","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5757881,0.21459526,0.097257175,0.0028401262,0.0007375046,0.0004556754,0.008119456,0.0011468627,0.09905983],"genre_scores_gemma":[0.9042089,0.033940528,0.020028265,0.00020486358,0.00008446401,0.00015180935,0.002229325,0.00011914198,0.039032698],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998777,0.0000217981,0.000007173219,0.000033398883,0.000012112655,0.00004782463],"domain_scores_gemma":[0.999946,0.000005431934,0.000007959405,0.00001112182,0.000013812056,0.000015684547],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032682906,0.0006362885,0.00041980337,0.0007157138,0.0005023851,0.0007573972,0.0006340309,0.00041825426,0.004092979],"category_scores_gemma":[0.00016635018,0.00024336483,0.0002389936,0.00087609276,0.00042073158,0.00057478534,0.00038839233,0.00038651322,0.0010788959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.004879517,0.00025525736,0.0019272341,0.0015829707,0.00021194622,0.0012727664,0.0003594406,0.007108191,0.6329004,0.042901628,0.005531213,0.30106947],"study_design_scores_gemma":[0.00006192368,0.0004385788,0.0009471115,0.000024112749,0.000052221305,0.000620797,0.00007159002,0.00072809163,0.89474565,0.003167893,0.09910953,0.0000324466],"about_ca_topic_score_codex":0.007671502,"about_ca_topic_score_gemma":0.0046573975,"teacher_disagreement_score":0.007671502,"about_ca_system_score_codex":0.0028921925,"about_ca_system_score_gemma":0.0014328661,"threshold_uncertainty_score":0.02098447},"labels":[],"label_agreement":null},{"id":"W2063541180","doi":"10.1016/j.bmcl.2007.07.050","title":"Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre","funders":"","keywords":"Chemistry; Thiazole; Hydroxamic acid; Histone deacetylase; HeLa; Histone deacetylase inhibitor; Sulfonamide; Stereochemistry; Piperazine; Cervical carcinoma; Ring (chemistry); Enzyme; Biochemistry; Histone; In vitro; Cancer; DNA; Cervical cancer; Organic chemistry","score_opus":0.009888275007316191,"score_gpt":0.26341793382902495,"score_spread":0.25352965882170875,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063541180","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91523474,0.020788437,0.04409779,0.0006390997,0.00038878273,0.00064631144,0.0010042553,0.0004583978,0.016742155],"genre_scores_gemma":[0.96807,0.008921692,0.01562209,0.00011950737,0.000050520634,0.00016626202,0.00059062045,0.000024805011,0.006434523],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999188,0.00001272138,0.000008280163,0.000013003661,0.000015460797,0.000031773816],"domain_scores_gemma":[0.99995184,0.0000054636257,0.000012546539,0.0000043647738,0.000009772708,0.000016070286],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024418088,0.00036713394,0.00036126634,0.0002386384,0.00022406809,0.0003119635,0.0005543499,0.00030389015,0.0016836366],"category_scores_gemma":[0.00017001062,0.00022039402,0.00022997329,0.00022337952,0.00017945883,0.00020621257,0.00018982707,0.00043378613,0.00047769104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006300493,0.00017240581,0.0002984675,0.0005081492,0.00004381683,0.0005485822,0.00016685667,0.0037420362,0.95844984,0.0033676738,0.0008745029,0.031197699],"study_design_scores_gemma":[0.00044843345,0.0022077626,0.0012516973,0.000039106664,0.00009813298,0.00054819905,0.00005231952,0.00452824,0.9492175,0.00035010936,0.04121786,0.000040652358],"about_ca_topic_score_codex":0.00096040184,"about_ca_topic_score_gemma":0.002335517,"teacher_disagreement_score":0.0016836366,"about_ca_system_score_codex":0.00049879495,"about_ca_system_score_gemma":0.00034379782,"threshold_uncertainty_score":0.0056322813},"labels":[],"label_agreement":null},{"id":"W2063593425","doi":"10.1016/j.bmcl.2009.12.076","title":"3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: A lead tumor-specific cytotoxin which induces apoptosis and autophagy","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; Morpholine; Apoptosis; Toxicity; DNA fragmentation; Autophagy; Cytotoxic T cell; Lead compound; Programmed cell death; Stereochemistry; Cytotoxicity; Caspase; In vitro; Cell culture; Fragmentation (computing); Biochemistry; Biology; Medicinal chemistry","score_opus":0.01579368637421112,"score_gpt":0.21912508065167113,"score_spread":0.20333139427746,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063593425","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96000576,0.0064200605,0.012443826,0.0005039307,0.00020908742,0.00011022653,0.0009080949,0.0007935799,0.018605443],"genre_scores_gemma":[0.9929103,0.001349376,0.002452281,0.000052265736,0.000025423478,0.000046864825,0.00032126385,0.00001845802,0.0028237351],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990773,0.000015376736,0.0000067361325,0.000017188706,0.000019177234,0.00003370251],"domain_scores_gemma":[0.9999474,0.000009594793,0.000018289511,0.000005820724,0.0000054659004,0.000013399409],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012475111,0.00029844005,0.00028179432,0.00019374595,0.00016750797,0.00015283389,0.00026689208,0.00025818383,0.0013102669],"category_scores_gemma":[0.000083831124,0.000112467766,0.00011473868,0.00014084198,0.00014690399,0.00021911487,0.00019407968,0.00037413897,0.0005772015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040160312,0.0000606104,0.00010622798,0.0001447914,0.000007934773,0.0001990121,0.000032122873,0.00027513976,0.99009717,0.0007677822,0.00037802738,0.0075295204],"study_design_scores_gemma":[0.00011546818,0.00096043386,0.0015943174,0.000008530764,0.000016486109,0.0005041019,0.000015963727,0.00075823546,0.98994243,0.000081977334,0.005993405,0.000008657001],"about_ca_topic_score_codex":0.0003772468,"about_ca_topic_score_gemma":0.0006977172,"teacher_disagreement_score":0.0013102669,"about_ca_system_score_codex":0.00026751368,"about_ca_system_score_gemma":0.000269765,"threshold_uncertainty_score":0.004383266},"labels":[],"label_agreement":null},{"id":"W2063702342","doi":"10.1016/j.bmcl.2010.10.131","title":"Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Diazepine; Chemistry; Stereochemistry; Capsid; Bicyclic molecule; Imidazole; Ring (chemistry); Pyrazole; Substituent; Biochemistry; Organic chemistry","score_opus":0.006118364677811453,"score_gpt":0.21560819250069554,"score_spread":0.20948982782288408,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063702342","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9357216,0.01893969,0.019354312,0.0010071548,0.00028290393,0.000578447,0.0012364014,0.00052090304,0.022358645],"genre_scores_gemma":[0.97196406,0.008767155,0.008269063,0.00044860764,0.00003768887,0.000096398806,0.0009170458,0.00002824468,0.009471762],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993026,0.000014565465,0.000004096414,0.000011706493,0.000017378003,0.000021981852],"domain_scores_gemma":[0.99994195,0.0000113907445,0.0000098239025,0.000004006833,0.000012102405,0.000020766403],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019273955,0.00031794223,0.00029412366,0.0003468301,0.0001563047,0.00039235843,0.0004164798,0.00024421254,0.0012829265],"category_scores_gemma":[0.00020197878,0.00017390227,0.00014164833,0.0001404232,0.00019691915,0.00014951742,0.00018136985,0.0005446865,0.00041298094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00033208888,0.00035251345,0.00053159153,0.00022977678,0.000030225185,0.00040673927,0.000120688994,0.0017583187,0.95787704,0.002740903,0.0014527757,0.034167327],"study_design_scores_gemma":[0.0006298193,0.0028829798,0.0055897105,0.00006581827,0.00007938011,0.0011661785,0.000052500833,0.007718591,0.9315938,0.0006166599,0.04955916,0.00004536511],"about_ca_topic_score_codex":0.0011478493,"about_ca_topic_score_gemma":0.005133137,"teacher_disagreement_score":0.0012829265,"about_ca_system_score_codex":0.0005802637,"about_ca_system_score_gemma":0.0003251893,"threshold_uncertainty_score":0.0042918324},"labels":[],"label_agreement":null},{"id":"W2063901699","doi":"10.1016/j.bmcl.2008.09.075","title":"The identification of neurotensin NTS1 receptor partial agonists through a ligand-based virtual screening approach","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Neurotensin; Virtual screening; Ligand (biochemistry); Agonist; Partial agonist; Identification (biology); Receptor; Pharmacology; Computational biology; Combinatorial chemistry; Stereochemistry; Biochemistry; Drug discovery; Neuropeptide","score_opus":0.03960897490759661,"score_gpt":0.24390143139572115,"score_spread":0.20429245648812455,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063901699","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87173915,0.0018656127,0.11092134,0.000506462,0.00004920241,0.00062736124,0.0012793359,0.0020616592,0.010950017],"genre_scores_gemma":[0.9469023,0.00050834345,0.050085284,0.0001371323,0.0000098039045,0.00018758194,0.00081495795,0.00002572414,0.0013288949],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9997111,0.00013403571,0.000014298192,0.000030021516,0.00007794656,0.000032602937],"domain_scores_gemma":[0.9998299,0.000100288846,0.000015311316,0.000011329668,0.00002516127,0.000018060213],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046946248,0.0007540193,0.0012523648,0.0009069355,0.00041652785,0.00088053365,0.00069717714,0.0004223112,0.0015605517],"category_scores_gemma":[0.00073944684,0.00026509073,0.00070295174,0.0005963239,0.00022292738,0.00033255573,0.0005128351,0.00033033377,0.00022202058],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022091246,0.0012932812,0.0053652762,0.0005745033,0.000914356,0.0009041486,0.00010927144,0.577763,0.12678425,0.004452388,0.0029380268,0.27669245],"study_design_scores_gemma":[0.0002606013,0.00086949894,0.0014418077,0.00001211983,0.00034787934,0.00033431148,0.000058595906,0.9619169,0.031308882,0.0013182182,0.0020926276,0.000038561066],"about_ca_topic_score_codex":0.0019694339,"about_ca_topic_score_gemma":0.0031081825,"teacher_disagreement_score":0.0019694339,"about_ca_system_score_codex":0.00040358846,"about_ca_system_score_gemma":0.0007187346,"threshold_uncertainty_score":0.0052205324},"labels":[],"label_agreement":null},{"id":"W2063908349","doi":"10.1016/s0960-894x(01)00056-7","title":"Structure–activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Prostanoid; Receptor; Chemical synthesis; Biochemistry; Stereochemistry; In vitro","score_opus":0.05295649835825523,"score_gpt":0.2740932272046116,"score_spread":0.22113672884635638,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063908349","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9954359,0.0020191974,0.0010766024,0.0000740335,0.000024484212,0.000030188241,0.00014029915,0.000025916132,0.0011733372],"genre_scores_gemma":[0.9964964,0.0010045086,0.0010157183,0.000032021275,0.000015775388,0.000016224869,0.00025682835,0.000008413314,0.0011542125],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998888,0.000028680255,0.0000075252847,0.00001234896,0.000034870645,0.000027802893],"domain_scores_gemma":[0.99987257,0.00006628579,0.000019604564,0.000013514107,0.000014788609,0.000013244659],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024882864,0.00023431939,0.00033618737,0.0001768645,0.00015667087,0.00025128285,0.0003093902,0.00025701575,0.0020262827],"category_scores_gemma":[0.0002945415,0.00011058355,0.00036451587,0.00022685294,0.00018851557,0.00014314859,0.00011224373,0.00043102214,0.00035436812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014538034,0.000312815,0.00021643282,0.00006208602,0.000031062867,0.00009577458,0.000023561286,0.00061672286,0.99029154,0.00020569099,0.000117097625,0.0065734107],"study_design_scores_gemma":[0.00017004681,0.0033296093,0.0014684115,0.0000044040667,0.00006265716,0.00019825465,0.000009864346,0.0024136382,0.9906342,0.00007077203,0.00162916,0.000008910741],"about_ca_topic_score_codex":0.00048020773,"about_ca_topic_score_gemma":0.00072408497,"teacher_disagreement_score":0.0020262827,"about_ca_system_score_codex":0.0001837744,"about_ca_system_score_gemma":0.0001784623,"threshold_uncertainty_score":0.006778598},"labels":[],"label_agreement":null},{"id":"W2063965714","doi":"10.1016/j.bmcl.2010.02.077","title":"First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Université du Québec à Montréal","keywords":"Chemistry; Testosterone (patch); Prostate cancer; Prostate; Differential (mechanical device); Chemical synthesis; Cancer; Stereochemistry; Cancer research; Endocrinology; Internal medicine; In vitro; Biochemistry","score_opus":0.005252201469023336,"score_gpt":0.2093838026901364,"score_spread":0.20413160122111307,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063965714","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94379705,0.007812011,0.027242238,0.00044555648,0.00024147377,0.00029723797,0.0028268553,0.0004646417,0.0168729],"genre_scores_gemma":[0.97310185,0.0027652055,0.0105570275,0.00009815638,0.00002561715,0.00006183027,0.0016592806,0.00008393845,0.011647119],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988127,0.000024989995,0.000008068219,0.000022001432,0.000021043063,0.000042561212],"domain_scores_gemma":[0.9999329,0.000011384092,0.000008831847,0.000013968528,0.000010793259,0.00002205002],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014068696,0.00047663832,0.0003977396,0.00020572847,0.00032333136,0.0003352239,0.00036094102,0.00023296119,0.0019832596],"category_scores_gemma":[0.00013254241,0.00017481016,0.00037688573,0.00031400958,0.00014344126,0.00015350647,0.00032053777,0.00054971385,0.0006343165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017715206,0.000026930707,0.00006994079,0.00005102013,0.000009402174,0.00010163368,0.00006003042,0.00017016819,0.99323493,0.00036379002,0.00024999894,0.005485038],"study_design_scores_gemma":[0.0000115607345,0.00016956376,0.00031077603,0.0000020546447,0.000011473504,0.00008231487,0.00002243609,0.00013622233,0.99559045,0.00004768069,0.003610603,0.00000481817],"about_ca_topic_score_codex":0.0010817111,"about_ca_topic_score_gemma":0.0017278674,"teacher_disagreement_score":0.0019832596,"about_ca_system_score_codex":0.00028397838,"about_ca_system_score_gemma":0.0003456782,"threshold_uncertainty_score":0.0066346526},"labels":[],"label_agreement":null},{"id":"W2064514724","doi":"10.1016/j.bmcl.2007.09.019","title":"New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Indole test; Stereochemistry; Moiety; Affinities; Selectivity; Agonist; Receptor; Chemical synthesis; Carboxamide; Binding affinities; Cannabinoid receptor type 2; Cannabinoid receptor; In vitro; Biochemistry","score_opus":0.008925312784583741,"score_gpt":0.277770133559887,"score_spread":0.26884482077530325,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2064514724","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.885726,0.040026307,0.017322978,0.001075391,0.0006285803,0.0003287862,0.0015805897,0.0013167185,0.051994618],"genre_scores_gemma":[0.964809,0.011317709,0.005590876,0.00041547406,0.000112490656,0.00011260797,0.0007653874,0.00007522111,0.016801294],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999918,0.000014817361,0.000004071842,0.000012025813,0.000015846666,0.000035258636],"domain_scores_gemma":[0.99996865,0.0000040821574,0.000005971115,0.0000035476817,0.0000054945785,0.000012329999],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015718592,0.0003205619,0.00041462074,0.00031789287,0.00027461696,0.0003811075,0.00060605345,0.00033630856,0.0043499856],"category_scores_gemma":[0.00009728067,0.00019387346,0.00020945328,0.00023366371,0.00020222562,0.00026870205,0.00021320912,0.0005565523,0.0008732965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006177223,0.00019829448,0.0001638999,0.00038455494,0.000023536253,0.00040570123,0.0001441344,0.0007213735,0.9620562,0.001987445,0.0021617524,0.031135382],"study_design_scores_gemma":[0.0005623366,0.0045592184,0.0062610568,0.00008851206,0.00013774331,0.0012091699,0.00012932657,0.00584761,0.90386856,0.0008037796,0.07642107,0.00011166758],"about_ca_topic_score_codex":0.001095477,"about_ca_topic_score_gemma":0.0046420423,"teacher_disagreement_score":0.0043499856,"about_ca_system_score_codex":0.00039591565,"about_ca_system_score_gemma":0.00021023519,"threshold_uncertainty_score":0.014552116},"labels":[],"label_agreement":null},{"id":"W2064593501","doi":"10.1016/j.bmcl.2006.08.056","title":"Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Valeant Pharmaceuticals International","keywords":"Chemistry; Allosteric regulation; NS5B; Scaffold; Stereochemistry; Potency; Structure–activity relationship; Combinatorial chemistry; Enzyme; Computational biology; Pharmacology; In vitro; Biochemistry; Hepacivirus; Biomedical engineering","score_opus":0.019293718688950138,"score_gpt":0.2618477527100557,"score_spread":0.2425540340211056,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2064593501","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9741933,0.0025872302,0.01356563,0.00043773957,0.00008157678,0.00030252154,0.0005713252,0.00029548912,0.007965184],"genre_scores_gemma":[0.991052,0.0009599312,0.0052011134,0.000058640147,0.000008100845,0.000054205917,0.00032930975,0.000011418445,0.0023253253],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999459,0.000009800024,0.0000042280785,0.000009322122,0.0000125722045,0.000018360051],"domain_scores_gemma":[0.99996555,0.000005591914,0.000008542832,0.0000035103271,0.000005515583,0.000011303564],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522576,0.0002774611,0.00035569284,0.00022562018,0.00028533343,0.0004553567,0.0005065649,0.00025450657,0.0023906776],"category_scores_gemma":[0.00012708471,0.00015886282,0.00023283885,0.00016633242,0.00021054572,0.00017163095,0.00022733405,0.0003734113,0.0004090179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013789444,0.0002057581,0.00051760155,0.00030663423,0.000037685248,0.0006617788,0.00016201,0.014378293,0.9576074,0.0035853963,0.0005831756,0.020575317],"study_design_scores_gemma":[0.0012057574,0.0045410367,0.0020021896,0.000054067157,0.00014721218,0.0005950369,0.00013634429,0.02359506,0.9443278,0.0007332353,0.02259475,0.00006744314],"about_ca_topic_score_codex":0.0014876724,"about_ca_topic_score_gemma":0.0030179578,"teacher_disagreement_score":0.0023906776,"about_ca_system_score_codex":0.0005556883,"about_ca_system_score_gemma":0.0005333412,"threshold_uncertainty_score":0.007997632},"labels":[],"label_agreement":null},{"id":"W2064968621","doi":"10.1016/j.bmcl.2010.07.127","title":"Identification of a new biaryl scaffold generating potent renin inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Renin inhibitor; Scaffold; Bioavailability; Combinatorial chemistry; Renin–angiotensin system; Molecular model; Chemical synthesis; Structure–activity relationship; Ring (chemistry); Drug discovery; Stereochemistry; Pharmacology; In vitro; Biochemistry; Organic chemistry","score_opus":0.006813896079529412,"score_gpt":0.21866471488664807,"score_spread":0.21185081880711865,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2064968621","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85540915,0.009987549,0.09911652,0.0018454635,0.00036797227,0.0005942831,0.0015818843,0.001324512,0.029772636],"genre_scores_gemma":[0.9561257,0.0052016475,0.024075363,0.0004176212,0.00006080646,0.00015249451,0.0013055076,0.00007464556,0.012586283],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998994,0.000013414697,0.00000827956,0.000019864965,0.000025452251,0.000033643366],"domain_scores_gemma":[0.9999465,0.0000055974524,0.000010999708,0.0000063000866,0.00001137756,0.000019334255],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025753723,0.00050943514,0.00037180484,0.00038920683,0.00023029189,0.00046685047,0.00054267125,0.00043743552,0.001598792],"category_scores_gemma":[0.00014866586,0.00018683012,0.00023086698,0.00024979038,0.00016383093,0.00047866875,0.0004892246,0.0006598208,0.00091005256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035752708,0.00028212115,0.00026234012,0.00020230202,0.00003021629,0.00053297175,0.00011099179,0.0009008594,0.95468,0.0054947645,0.0013173785,0.03582846],"study_design_scores_gemma":[0.0003452586,0.0030070327,0.0012694972,0.0000311929,0.000109134315,0.0010505974,0.00006060601,0.004040848,0.9449736,0.0014730042,0.04357659,0.000062693274],"about_ca_topic_score_codex":0.00040846947,"about_ca_topic_score_gemma":0.0009953794,"teacher_disagreement_score":0.001598792,"about_ca_system_score_codex":0.0003082931,"about_ca_system_score_gemma":0.00029344304,"threshold_uncertainty_score":0.005348563},"labels":[],"label_agreement":null},{"id":"W2065152761","doi":"10.1016/j.bmcl.2005.05.095","title":"Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Potency; Indole test; Plasminogen activator inhibitor-1; Carboxylic acid; Activator (genetics); Stereochemistry; Plasminogen activator; Biochemistry; Chemical synthesis; Enzyme inhibitor; Structure–activity relationship; In vitro; Receptor","score_opus":0.00617800579953241,"score_gpt":0.20800489441663653,"score_spread":0.20182688861710413,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2065152761","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9100095,0.030438367,0.025510274,0.0011378827,0.00058620464,0.0007799535,0.0017662825,0.0004998719,0.029271573],"genre_scores_gemma":[0.9665395,0.014325043,0.007457012,0.0002994549,0.00012059571,0.00012699032,0.0013113612,0.00002988659,0.009790029],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999913,0.000016158825,0.00000553368,0.000007643904,0.00001825995,0.00003953191],"domain_scores_gemma":[0.9999459,0.000008536703,0.000010203833,0.0000039500933,0.000009496507,0.00002178984],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028437856,0.0004367722,0.00032270837,0.0002490171,0.00019123538,0.00030794556,0.0005724388,0.00033750595,0.0014500901],"category_scores_gemma":[0.00018444184,0.00018479883,0.0002870598,0.0002210348,0.00013881829,0.0002406596,0.00020086065,0.0005659833,0.00075668195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014558946,0.0006637725,0.00044570616,0.0007073879,0.000056002395,0.0016179451,0.00039504666,0.010670742,0.92292213,0.004288488,0.0031746328,0.0536022],"study_design_scores_gemma":[0.0008649962,0.007825971,0.0041836104,0.00011907106,0.000108039436,0.0010536173,0.00013315184,0.011009228,0.89547104,0.0010010371,0.07814035,0.0000899112],"about_ca_topic_score_codex":0.0010316864,"about_ca_topic_score_gemma":0.0019503097,"teacher_disagreement_score":0.0014500901,"about_ca_system_score_codex":0.0003492386,"about_ca_system_score_gemma":0.0004401705,"threshold_uncertainty_score":0.004851043},"labels":[],"label_agreement":null},{"id":"W2065196756","doi":"10.1016/j.bmcl.2004.04.064","title":"Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Chemistry; Linker; Bifunctional; Estrogen receptor; Estrogen; DNA; Aniline; Combinatorial chemistry; Cancer cell; Chemical synthesis; Covalent bond; Biochemistry; Cancer; Breast cancer; Stereochemistry; In vitro; Organic chemistry; Genetics; Biology","score_opus":0.021462430596143393,"score_gpt":0.27996453175829594,"score_spread":0.25850210116215255,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2065196756","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9597551,0.0123076,0.021480868,0.00019138846,0.000114343224,0.0004326697,0.000505563,0.00011402666,0.00509853],"genre_scores_gemma":[0.96031195,0.013925735,0.018294265,0.00014899367,0.000032242828,0.00022015489,0.000694771,0.000038173945,0.006333729],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998772,0.00003150327,0.000016311029,0.000020887128,0.000028995226,0.000025100002],"domain_scores_gemma":[0.99991024,0.000013934842,0.000022920747,0.000011258035,0.00002526221,0.000016420887],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040037915,0.0003347292,0.00027503067,0.00035806454,0.00018334402,0.00025921038,0.00040266596,0.00028418502,0.0013481408],"category_scores_gemma":[0.00023711767,0.00021563731,0.00025894484,0.00019743881,0.00016736092,0.00023355767,0.00021220541,0.00024809546,0.00035622052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006143243,0.00028738222,0.0005131357,0.00034754333,0.00004169502,0.00034381408,0.000081743645,0.0028091935,0.96483976,0.0016204618,0.00016207345,0.02833891],"study_design_scores_gemma":[0.00006909904,0.001178128,0.00037933595,0.000010941296,0.000034530927,0.00010900288,0.000013766613,0.00033763962,0.99036294,0.00007859214,0.007420227,0.000005859639],"about_ca_topic_score_codex":0.00025208938,"about_ca_topic_score_gemma":0.000648043,"teacher_disagreement_score":0.0013481408,"about_ca_system_score_codex":0.0002320417,"about_ca_system_score_gemma":0.00027466644,"threshold_uncertainty_score":0.0045099854},"labels":[],"label_agreement":null},{"id":"W2065203307","doi":"10.1016/j.bmcl.2014.09.008","title":"Synthesis and evaluation of anti-inflammatory activity of derivatives of the marine natural products fuscol and eunicol","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"St. Francis Xavier University; University of Calgary; Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"St. Francis Xavier University","keywords":"Chemistry; Terpene; Cyclohexane; Anti-inflammatory; Total synthesis; Natural product; Stereochemistry; Combinatorial chemistry; Organic chemistry; Pharmacology; Biology","score_opus":0.007768954568977539,"score_gpt":0.22331698197583078,"score_spread":0.21554802740685325,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2065203307","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99284804,0.00241476,0.0014606625,0.000048921698,0.000025873765,0.00005161527,0.00041786386,0.000024327788,0.0027079384],"genre_scores_gemma":[0.9964904,0.0011431199,0.0010536368,0.000021015807,0.000007372038,0.00001612454,0.00032028463,0.0000053469853,0.00094255235],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999517,0.000009860851,0.0000056843714,0.000005783664,0.000009512851,0.000017353035],"domain_scores_gemma":[0.9999534,0.0000061674664,0.000011102763,0.0000053952044,0.000008375253,0.000015635113],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010158633,0.00029631992,0.00016025706,0.00034356175,0.00015070716,0.00013091516,0.00016638445,0.00018478633,0.0012322218],"category_scores_gemma":[0.00013444155,0.0000737428,0.00025908017,0.0003171627,0.00011985156,0.00021263013,0.00013953811,0.00019855569,0.00015419994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010077977,0.00015079277,0.00041782108,0.00015876936,0.000022179933,0.00038964007,0.0000551145,0.0005772687,0.98589015,0.00040719053,0.0000795522,0.010843658],"study_design_scores_gemma":[0.00007335642,0.0021511733,0.0024687818,0.000016316306,0.000056376914,0.00020626657,0.00004080899,0.0003957994,0.98940814,0.000066447436,0.005106374,0.000010157154],"about_ca_topic_score_codex":0.0006092858,"about_ca_topic_score_gemma":0.0006914726,"teacher_disagreement_score":0.0012322218,"about_ca_system_score_codex":0.0001342348,"about_ca_system_score_gemma":0.00019562825,"threshold_uncertainty_score":0.004122257},"labels":[],"label_agreement":null},{"id":"W2065346882","doi":"10.1016/j.bmcl.2011.08.073","title":"Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Triazole; Pharmacology; Liver toxicity; Dosing; Toxicity; Adverse effect; Medicine","score_opus":0.017894789345667846,"score_gpt":0.2089165260078166,"score_spread":0.19102173666214875,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2065346882","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9722396,0.0026755652,0.015471958,0.00025566018,0.00010173077,0.00011534348,0.00054999726,0.00043285312,0.008157247],"genre_scores_gemma":[0.9929569,0.0007646768,0.0018114559,0.000041150608,0.000007660401,0.000019925645,0.0002528796,0.000015759551,0.0041295756],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993706,0.0000071824415,0.0000031305428,0.000013066801,0.00001413629,0.000025449666],"domain_scores_gemma":[0.9999783,0.000003268178,0.00000555265,0.000003154462,0.0000034096388,0.0000061638916],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012235144,0.00025134874,0.00019301136,0.00012804077,0.000095843694,0.00019253843,0.00016563699,0.00023035951,0.00173992],"category_scores_gemma":[0.00008687643,0.000091544,0.00020639315,0.00012960784,0.000113837836,0.00015375228,0.00015503573,0.00035444464,0.0003714136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030608213,0.00005905131,0.00012733728,0.000050350263,0.0000149342395,0.00013740332,0.0000202656,0.00039443542,0.9908342,0.0005225346,0.00037461967,0.0071590003],"study_design_scores_gemma":[0.000029287614,0.00047093502,0.0004313709,0.000002414816,0.000012431623,0.00012195157,0.000010367365,0.00060742727,0.9956038,0.000043158565,0.0026626666,0.0000040703508],"about_ca_topic_score_codex":0.00066698325,"about_ca_topic_score_gemma":0.0016284892,"teacher_disagreement_score":0.00173992,"about_ca_system_score_codex":0.0002666423,"about_ca_system_score_gemma":0.00013717258,"threshold_uncertainty_score":0.005820632},"labels":[],"label_agreement":null},{"id":"W2065685500","doi":"10.1016/j.bmcl.2009.08.032","title":"Structure–activity studies on seco-pancratistatin analogs: Potent inhibitors of human cytochrome P450 3A4","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Chemistry; CYP3A4; Stereochemistry; Cytochrome P450; Structure–activity relationship; Chemical synthesis; Derivative (finance); Biochemistry; In vitro; Combinatorial chemistry; Enzyme","score_opus":0.01653172149962169,"score_gpt":0.2687195763330307,"score_spread":0.252187854833409,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2065685500","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99142516,0.004410321,0.00067736994,0.00014058159,0.000047807716,0.00010615278,0.0007054474,0.000041262894,0.0024458233],"genre_scores_gemma":[0.99435365,0.002835505,0.0005682443,0.00005231835,0.00003243057,0.000026061427,0.0007277403,0.000008771293,0.0013952805],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985135,0.000052599687,0.000013559079,0.000018827199,0.000028062479,0.000035577188],"domain_scores_gemma":[0.99982977,0.000043273987,0.000040773597,0.000015133596,0.00002364151,0.00004738434],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025800322,0.00034019674,0.0004254577,0.00023012725,0.00017139396,0.00016184723,0.0003045947,0.00024950382,0.0018137178],"category_scores_gemma":[0.0002947994,0.00018858264,0.0003137977,0.00029133313,0.00019698676,0.00021890605,0.000114230934,0.00054825447,0.00035418675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.008536992,0.0014577352,0.0012473968,0.00026147443,0.00014305991,0.0004911425,0.000112565955,0.0034007977,0.96327966,0.00029703372,0.0007944855,0.019977693],"study_design_scores_gemma":[0.003370249,0.068339676,0.018276492,0.000024842317,0.00041478992,0.0022640638,0.00009437433,0.0045410604,0.89195526,0.00016223869,0.010512486,0.000044527525],"about_ca_topic_score_codex":0.0011054681,"about_ca_topic_score_gemma":0.0025079658,"teacher_disagreement_score":0.0018137178,"about_ca_system_score_codex":0.00023863431,"about_ca_system_score_gemma":0.00022905615,"threshold_uncertainty_score":0.006067455},"labels":[],"label_agreement":null},{"id":"W2065937077","doi":"10.1016/s0960-894x(00)00545-x","title":"Synthesis of a statistically exhaustive fluorescent peptide substrate library for profiling protease specificity","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AXYS Technologies (Canada)","funders":"","keywords":"Chemistry; Proteases; Protease; Peptide library; Peptide; Serine protease; Cysteine; Serine; Profiling (computer programming); High-throughput screening; Combinatorial chemistry; Substrate specificity; Chemical synthesis; Fluorescence; Biochemistry; Chromatography; In vitro; Enzyme; Peptide sequence; Gene","score_opus":0.008115518287748648,"score_gpt":0.21628733695675895,"score_spread":0.2081718186690103,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2065937077","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7498948,0.0012251335,0.23932534,0.00019487456,0.00002142624,0.0004520003,0.0048655635,0.0015453295,0.0024754726],"genre_scores_gemma":[0.7911974,0.0015671048,0.19292758,0.00025148658,0.00003103998,0.0007129568,0.010304534,0.00020561629,0.0028021876],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9995276,0.00007481889,0.000036362864,0.00010496707,0.00017621863,0.00008009353],"domain_scores_gemma":[0.9993242,0.00024272541,0.000108368884,0.00009399103,0.00014545779,0.00008520398],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006361955,0.00057605555,0.00083042006,0.000840798,0.00042385326,0.0005644296,0.00040564802,0.00034745128,0.0017263063],"category_scores_gemma":[0.0013841835,0.0003518959,0.00046377763,0.0010020207,0.00026800664,0.00035622614,0.00044058292,0.0005707581,0.0007272949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030665484,0.00008712516,0.00078976195,0.00007587359,0.000030872223,0.00011276254,0.000020617374,0.0023281865,0.97434235,0.00029306006,0.00019922067,0.0214136],"study_design_scores_gemma":[0.000044304208,0.0006274969,0.0026191275,0.000007415219,0.00006519095,0.00052766316,0.00001837447,0.009362767,0.9840088,0.0003000085,0.0023941507,0.000024757926],"about_ca_topic_score_codex":0.0008340906,"about_ca_topic_score_gemma":0.002311005,"teacher_disagreement_score":0.0017263063,"about_ca_system_score_codex":0.00047449706,"about_ca_system_score_gemma":0.0012916151,"threshold_uncertainty_score":0.0057750344},"labels":[],"label_agreement":null},{"id":"W2066288117","doi":"10.1016/j.bmcl.2013.03.073","title":"Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: Addressing configurational instability through scaffold modification","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Diazepine; Capsid; Scaffold; Stereochemistry; Series (stratigraphy); Human immunodeficiency virus (HIV); Combinatorial chemistry; Virology; Organic chemistry; Biochemistry; Ring (chemistry)","score_opus":0.02493696215396006,"score_gpt":0.25137057921075967,"score_spread":0.2264336170567996,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066288117","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9794719,0.004272534,0.007453475,0.00015627661,0.00007442337,0.0002742264,0.00071344984,0.00023016303,0.0073535736],"genre_scores_gemma":[0.98821497,0.0022394771,0.006027333,0.00007942634,0.000011061206,0.00005835713,0.0005738369,0.000023770592,0.0027716914],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998822,0.000020072766,0.000010924641,0.000025333855,0.000030799867,0.00003066277],"domain_scores_gemma":[0.9999293,0.000009547174,0.00002334662,0.000006223506,0.000014096574,0.000017515818],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019734979,0.00056899444,0.00038288315,0.00029300246,0.00017269123,0.00033051614,0.00046827382,0.0002332608,0.0012826285],"category_scores_gemma":[0.00016981766,0.0001664092,0.00017520048,0.00023679029,0.00016670825,0.00021049596,0.0001986532,0.0004029513,0.00043670143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039750696,0.00030088171,0.00033191056,0.00017169902,0.000019698206,0.0002728556,0.00006261766,0.003117815,0.9796524,0.00066883705,0.00030603784,0.01469763],"study_design_scores_gemma":[0.00017863189,0.002710108,0.001523128,0.000023165467,0.000058589994,0.00035216444,0.00002754212,0.002931842,0.9816613,0.00010254016,0.010401517,0.000029509265],"about_ca_topic_score_codex":0.00085333065,"about_ca_topic_score_gemma":0.004723908,"teacher_disagreement_score":0.0012826285,"about_ca_system_score_codex":0.000435424,"about_ca_system_score_gemma":0.0004988641,"threshold_uncertainty_score":0.004290819},"labels":[],"label_agreement":null},{"id":"W2066313579","doi":"10.1016/j.bmcl.2006.09.079","title":"Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Stereochemistry; Enantiomer; Deprotonation; Protonation; Chemical synthesis; In vitro; Biochemistry; Organic chemistry","score_opus":0.002972504797149778,"score_gpt":0.1797084143894373,"score_spread":0.17673590959228752,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066313579","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96860135,0.007965452,0.008038782,0.00033690158,0.00015333324,0.0002915548,0.00037931313,0.0005260554,0.013707195],"genre_scores_gemma":[0.99290586,0.0012954741,0.0019077347,0.000042395495,0.000021159462,0.00004409986,0.00033965876,0.000016078537,0.0034275425],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998555,0.000026893398,0.00000915632,0.000021984612,0.000030774914,0.00005566997],"domain_scores_gemma":[0.99994004,0.000011030027,0.000014890571,0.0000082598945,0.000009726375,0.000015979624],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026767974,0.0004698963,0.00040910175,0.00025620518,0.00020823284,0.0003473544,0.0005227859,0.00036675893,0.0015283892],"category_scores_gemma":[0.00017886485,0.00014502478,0.00024248194,0.00011131588,0.00020764854,0.00029042902,0.00021337363,0.0004842318,0.00037536182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014881088,0.00020865192,0.00024595243,0.00014245634,0.000032014108,0.0002701583,0.000058972815,0.00068918895,0.9778416,0.0019954003,0.0007762103,0.016251191],"study_design_scores_gemma":[0.00010800398,0.000952211,0.0004699694,0.0000045396496,0.000019557487,0.0002747978,0.0000078756675,0.00095779763,0.98944116,0.00007849638,0.0076762233,0.0000093444205],"about_ca_topic_score_codex":0.00096913084,"about_ca_topic_score_gemma":0.0016961463,"teacher_disagreement_score":0.0015283892,"about_ca_system_score_codex":0.00057771604,"about_ca_system_score_gemma":0.00018918922,"threshold_uncertainty_score":0.005112946},"labels":[],"label_agreement":null},{"id":"W2066496540","doi":"10.1016/j.bmcl.2008.06.030","title":"A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Sulfonyl; Stereochemistry; Chemical synthesis; Sulfonamide; Combinatorial chemistry; In vitro; Organic chemistry; Biochemistry","score_opus":0.014845420442948891,"score_gpt":0.20036281196436984,"score_spread":0.18551739152142094,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066496540","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9247488,0.011540026,0.033036426,0.0006078422,0.00021321746,0.00041368106,0.0015540101,0.0005895258,0.027296487],"genre_scores_gemma":[0.97537994,0.005400166,0.010146679,0.00016798172,0.000050779934,0.00011508071,0.00084446184,0.00003438676,0.007860441],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988437,0.000025407733,0.000009763805,0.000015745418,0.000025629386,0.000039075003],"domain_scores_gemma":[0.99995315,0.000007256758,0.0000120586,0.000005597116,0.000008613144,0.000013424556],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378277,0.00045879046,0.00031643177,0.00024159784,0.00020486717,0.00020013403,0.00060498755,0.0003192693,0.0018801965],"category_scores_gemma":[0.00013980462,0.00015480086,0.00017594795,0.00019374577,0.0001601715,0.0002477213,0.00027963452,0.00058147113,0.00072196446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028721904,0.00017435141,0.00026763638,0.0003062824,0.00003156282,0.00057334703,0.00014954353,0.0015077983,0.9603621,0.0030691396,0.0011551372,0.03211588],"study_design_scores_gemma":[0.00009404527,0.0016181315,0.001435655,0.000022412181,0.000047421436,0.0009307091,0.000037197486,0.0018350605,0.9749737,0.00031338053,0.018665122,0.000027223634],"about_ca_topic_score_codex":0.00053032604,"about_ca_topic_score_gemma":0.001835445,"teacher_disagreement_score":0.0018801965,"about_ca_system_score_codex":0.00033148145,"about_ca_system_score_gemma":0.0002787306,"threshold_uncertainty_score":0.0062898993},"labels":[],"label_agreement":null},{"id":"W2066531636","doi":"10.1016/j.bmcl.2015.03.029","title":"Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4: Design, synthesis and biological evaluations","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Genomics; Health Sciences Centre; Ottawa Hospital","funders":"","keywords":"Kexin; Proprotein Convertases; Chemistry; Furin; Subtilisin; Biochemistry; Proprotein convertase; Enzyme; Serine; In vitro; Cell growth; LDL receptor; Lipoprotein","score_opus":0.027502464067392946,"score_gpt":0.2514611524386064,"score_spread":0.22395868837121344,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066531636","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99036705,0.005015117,0.0015357553,0.000074400414,0.000046742065,0.00007531727,0.00017390697,0.000041466854,0.0026703377],"genre_scores_gemma":[0.9908139,0.0034604587,0.0014314103,0.000035753073,0.000011589304,0.00003259828,0.00021972207,0.00000816974,0.0039864425],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993587,0.000012707034,0.000006474292,0.000009293828,0.000015311976,0.00002044499],"domain_scores_gemma":[0.9999541,0.0000073821716,0.00001048964,0.000004214261,0.0000069827306,0.000016828164],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019448703,0.00028405798,0.00017929634,0.0001939622,0.00008758916,0.00022479327,0.0002673357,0.00017407697,0.0010982205],"category_scores_gemma":[0.00011539031,0.000116900505,0.0001239746,0.00013528438,0.00014083044,0.0002120438,0.00012146147,0.00030128343,0.00024245559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019892622,0.00032074843,0.00039377026,0.00012644156,0.000025418469,0.00026374662,0.0000518122,0.001947407,0.9682399,0.00075396267,0.00021747012,0.025670007],"study_design_scores_gemma":[0.00059792976,0.004307431,0.0023532996,0.000008713959,0.0000601927,0.0003450468,0.000029337954,0.0017379802,0.9825576,0.00009751025,0.007888863,0.00001608331],"about_ca_topic_score_codex":0.0005034858,"about_ca_topic_score_gemma":0.00084246893,"teacher_disagreement_score":0.0010982205,"about_ca_system_score_codex":0.00022340914,"about_ca_system_score_gemma":0.00017448193,"threshold_uncertainty_score":0.003673911},"labels":[],"label_agreement":null},{"id":"W2066593112","doi":"10.1016/s0960-894x(02)00768-0","title":"Synthesis of [Difluoro-(3-alkenylphenyl)-methyl]-phosphonic acids on non-crosslinked polystyrene and Their evaluation as inhibitors of PTP1B","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Moiety; Polystyrene; Chemical synthesis; Cleavage (geology); Enzyme inhibitor; Stereochemistry; Polymer; Enzyme; Organic chemistry; In vitro; Biochemistry","score_opus":0.00930590476917684,"score_gpt":0.2252722393426692,"score_spread":0.21596633457349237,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066593112","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96626073,0.0036419807,0.019283816,0.0001541861,0.00016943656,0.00019684061,0.0006942343,0.0002848751,0.009313859],"genre_scores_gemma":[0.96911937,0.0030508416,0.017776664,0.00012240035,0.000052678086,0.00014855893,0.0007763823,0.00007778007,0.008875426],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99979013,0.000031171174,0.00001859109,0.000035642963,0.000058278976,0.00006622466],"domain_scores_gemma":[0.99982303,0.000034835444,0.00004426476,0.000021714188,0.00002415723,0.000052055064],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002757898,0.0005737,0.00029401435,0.00037761757,0.00029257566,0.00022110458,0.0004259822,0.0005091934,0.0022200635],"category_scores_gemma":[0.0002755259,0.0003154243,0.00035950317,0.00037253345,0.00015953468,0.00030298613,0.00028092222,0.00046422478,0.0009744444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017114225,0.00005984613,0.000049125098,0.00008934523,0.000011903202,0.000127269,0.000032770527,0.00061696,0.99412954,0.0003348236,0.000082353676,0.004294981],"study_design_scores_gemma":[0.000021533462,0.0002642393,0.00041747032,0.0000053197296,0.000013016215,0.000048741287,0.000006550671,0.00053800194,0.996752,0.00004172695,0.0018840295,0.0000073794326],"about_ca_topic_score_codex":0.0006162082,"about_ca_topic_score_gemma":0.00095224666,"teacher_disagreement_score":0.0022200635,"about_ca_system_score_codex":0.00027683488,"about_ca_system_score_gemma":0.00039983675,"threshold_uncertainty_score":0.007426858},"labels":[],"label_agreement":null},{"id":"W2066639712","doi":"10.1016/j.bmcl.2014.11.046","title":"Investigating the binding interactions of the anti-Alzheimer’s drug donepezil with CYP3A4 and P-glycoprotein","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Donepezil; Chemistry; Pharmacology; CYP3A4; Ketoconazole; P-glycoprotein; IC50; In vivo; Stereochemistry; Biochemistry; In vitro; Enzyme; Cytochrome P450; Internal medicine; Medicine; Biology","score_opus":0.01030511197426283,"score_gpt":0.21501320569448135,"score_spread":0.2047080937202185,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066639712","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9950051,0.0016826487,0.0011320355,0.00016579911,0.0000178638,0.00002285922,0.00011427408,0.000018120383,0.0018413861],"genre_scores_gemma":[0.99636674,0.0009346315,0.0007416113,0.000056155135,0.000010254991,0.000008279409,0.00018309215,0.000006161941,0.0016931196],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997279,0.00008683681,0.0000070680585,0.000041441574,0.000067843685,0.000068922054],"domain_scores_gemma":[0.99987614,0.000054932454,0.00001979104,0.000009612792,0.00002768702,0.000011858118],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026184059,0.00026090708,0.00032591895,0.00016016357,0.00037499433,0.0003082637,0.00031664452,0.00040668744,0.0019279822],"category_scores_gemma":[0.0005916909,0.0002096319,0.00052069296,0.00024476968,0.00016491378,0.0003158564,0.00013962477,0.00044407524,0.0004398299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017189506,0.000279481,0.008161664,0.00027337053,0.0002732647,0.00062025856,0.00014946348,0.002028151,0.97272146,0.00063966884,0.0007052053,0.012428985],"study_design_scores_gemma":[0.00009979328,0.0017674246,0.032034185,0.000011478836,0.0003078182,0.0017509848,0.00022600908,0.019020552,0.93890464,0.0003220393,0.0055187345,0.00003638551],"about_ca_topic_score_codex":0.0066729253,"about_ca_topic_score_gemma":0.00594669,"teacher_disagreement_score":0.0066729253,"about_ca_system_score_codex":0.0005644167,"about_ca_system_score_gemma":0.00032825017,"threshold_uncertainty_score":0.013268173},"labels":[],"label_agreement":null},{"id":"W2066749464","doi":"10.1016/j.bmcl.2009.10.031","title":"Synthesis and PKCθ inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Sulfonamide; Chemistry; Protein kinase C; IC50; Selectivity; Stereochemistry; Inhibitory postsynaptic potential; Enzyme inhibitor; Chemical synthesis; Combinatorial chemistry; Enzyme; In vitro; Biochemistry; Internal medicine","score_opus":0.007060881588123434,"score_gpt":0.20876561891774323,"score_spread":0.2017047373296198,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066749464","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9839744,0.004467731,0.004676965,0.00014378587,0.0000740637,0.00007842248,0.00026627062,0.0001304646,0.006187941],"genre_scores_gemma":[0.9918283,0.00275678,0.0024112654,0.000047768626,0.000025191222,0.00005046128,0.00031246853,0.0000127134035,0.0025550218],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988186,0.000020044392,0.00001259277,0.000017375734,0.000029037283,0.000039012277],"domain_scores_gemma":[0.9998994,0.000016549024,0.00003436678,0.000014464521,0.000011410079,0.000023775114],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000262515,0.00039502667,0.00021668947,0.0002746413,0.00019570977,0.00019013701,0.0004315869,0.00027120917,0.0019054001],"category_scores_gemma":[0.00020935765,0.00014793294,0.00022535854,0.00018667964,0.00019335028,0.00022988426,0.00019541236,0.00045619108,0.00037815812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004145214,0.00014355125,0.00020398448,0.00015703386,0.000015710959,0.00028027332,0.000046785244,0.0013035381,0.98659,0.000969724,0.00020181015,0.009672953],"study_design_scores_gemma":[0.00006623545,0.0013104206,0.0010830087,0.000011799905,0.000022131871,0.0003138955,0.000019649831,0.0009504585,0.9925291,0.00007559256,0.0036034437,0.000014184524],"about_ca_topic_score_codex":0.00058353425,"about_ca_topic_score_gemma":0.00093504007,"teacher_disagreement_score":0.0019054001,"about_ca_system_score_codex":0.000299471,"about_ca_system_score_gemma":0.00041176213,"threshold_uncertainty_score":0.00637424},"labels":[],"label_agreement":null},{"id":"W2066781884","doi":"10.1016/j.bmcl.2008.07.104","title":"Corrigendum to “Novel benzimidazole derivatives as selective CB2 agonists” [Bioorg. Med. Chem. Lett. 18 (2008) 3695–3700]","year":2008,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Diet and metabolism studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Benzimidazole; Organic chemistry","score_opus":0.027752846897255313,"score_gpt":0.26792619393869366,"score_spread":0.24017334704143833,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066781884","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00023133692,0.007495667,0.00041680297,0.032920975,0.94773775,0.00009705836,0.0009039965,0.0003429517,0.009853408],"genre_scores_gemma":[0.012356303,0.037526302,0.0032244564,0.08014734,0.28910983,0.00033763386,0.0038885802,0.00048870774,0.57292086],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9974299,0.00027036804,0.0003654108,0.00039215945,0.0010358131,0.0005064549],"domain_scores_gemma":[0.99405354,0.0012383044,0.00047850856,0.00039903066,0.0030524114,0.0007781722],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001999792,0.0039256625,0.0038320995,0.0034774938,0.0033029811,0.0025494024,0.005486997,0.008491909,0.115595035],"category_scores_gemma":[0.010762725,0.00169996,0.0034440723,0.0027713506,0.001904498,0.0024635063,0.0017941789,0.0054178373,0.06542903],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014108955,0.000031686934,0.00005944934,0.00043659948,0.00003484476,0.000708729,0.000012788611,0.000081663755,0.00051384367,0.0005547403,0.9880884,0.009336048],"study_design_scores_gemma":[0.00012580972,0.00012906284,0.0016372816,0.00019639275,0.000110395,0.0007981159,0.00003843554,0.0002213374,0.0021655103,0.00081136153,0.993694,0.000072272764],"about_ca_topic_score_codex":0.012570239,"about_ca_topic_score_gemma":0.01980099,"teacher_disagreement_score":0.115595035,"about_ca_system_score_codex":0.0048812972,"about_ca_system_score_gemma":0.0030720558,"threshold_uncertainty_score":0.38670397},"labels":[],"label_agreement":null},{"id":"W2066864308","doi":"10.1016/j.bmcl.2011.03.084","title":"Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Antagonist; Nucleotide; Pharmacology; In vivo; Pyrimidine; P2Y receptor; Bioavailability; Receptor; Receptor antagonist; Competitive antagonist; Stereochemistry; Biochemistry; Agonist; Biology; Biotechnology","score_opus":0.012213458899416838,"score_gpt":0.20728868632832165,"score_spread":0.19507522742890482,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066864308","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8658482,0.02954803,0.054857403,0.0014202636,0.0005294898,0.0014923654,0.0028104167,0.00049181696,0.04300201],"genre_scores_gemma":[0.9170326,0.02612464,0.027625473,0.0006857957,0.00014935299,0.000533203,0.0030576657,0.00007760703,0.024713747],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998766,0.000024190873,0.00001302585,0.000014260085,0.000029719831,0.000042255466],"domain_scores_gemma":[0.9999521,0.0000075995135,0.000009846307,0.00000537566,0.0000090564945,0.000015945596],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026396642,0.0004463394,0.0004869774,0.0002472364,0.00028859242,0.00036979897,0.0006498756,0.00042371024,0.003491735],"category_scores_gemma":[0.00023852717,0.00027840497,0.0003063222,0.00022105128,0.00014817661,0.00036600014,0.00035353532,0.0005949992,0.0013025705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089222053,0.00051055884,0.00026753612,0.00087715196,0.00007492049,0.0010435499,0.00022789193,0.006422655,0.89236283,0.009136987,0.0040146844,0.08416905],"study_design_scores_gemma":[0.0008248769,0.008218236,0.0023096867,0.00012334315,0.00012585316,0.0017048001,0.00009750912,0.007071855,0.8671642,0.0021319713,0.11012864,0.00009901397],"about_ca_topic_score_codex":0.0004420202,"about_ca_topic_score_gemma":0.0014315391,"teacher_disagreement_score":0.003491735,"about_ca_system_score_codex":0.00034739333,"about_ca_system_score_gemma":0.0005306094,"threshold_uncertainty_score":0.01168102},"labels":[],"label_agreement":null},{"id":"W2067507638","doi":"10.1016/j.bmcl.2011.12.002","title":"Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Stearoyl-CoA Desaturase; Pharmacology; Pharmacokinetics; Drug discovery; Biochemistry; Biology; Gene; Gene expression","score_opus":0.009644974009055677,"score_gpt":0.19470421693885476,"score_spread":0.18505924292979908,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2067507638","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8662809,0.04331275,0.052551992,0.0015615681,0.00085433386,0.0007075048,0.0020087813,0.0013188303,0.03140328],"genre_scores_gemma":[0.951311,0.021700602,0.014893009,0.00048348834,0.00010519833,0.00019589861,0.0010064029,0.00006774531,0.010236577],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999292,0.000010269156,0.000005988056,0.000014858224,0.000017018345,0.000022645543],"domain_scores_gemma":[0.99994504,0.0000071388276,0.0000133260255,0.0000036802844,0.000011323422,0.00001940409],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021429805,0.0005433047,0.00035102188,0.00028292442,0.00012926607,0.0003140883,0.00042118347,0.0002868847,0.0017308005],"category_scores_gemma":[0.0001675185,0.00022904153,0.000206188,0.00014026863,0.00014837088,0.00026925572,0.0002579651,0.0006233767,0.0006162751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008965386,0.00031884498,0.00029832238,0.00041982424,0.000048664973,0.00052836334,0.00009942756,0.0027208282,0.9372337,0.0038196228,0.0026173724,0.05099839],"study_design_scores_gemma":[0.0005882901,0.0037549809,0.0016178736,0.000050194147,0.00011637492,0.0008658015,0.00002786599,0.0049875425,0.9295959,0.0006175325,0.057726286,0.000051361047],"about_ca_topic_score_codex":0.00037788783,"about_ca_topic_score_gemma":0.0013140868,"teacher_disagreement_score":0.0017308005,"about_ca_system_score_codex":0.00037624888,"about_ca_system_score_gemma":0.00019679435,"threshold_uncertainty_score":0.0057901144},"labels":[],"label_agreement":null},{"id":"W2067671430","doi":"10.1016/j.bmcl.2012.01.044","title":"3,4-Diarylpiperidines as potent renin inhibitors","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); GLS Industries (Canada)","funders":"","keywords":"Chemistry; Renin–angiotensin system; Enzyme inhibitor; Pharmacology; Stereochemistry; Enzyme; Biochemistry; Internal medicine","score_opus":0.013248684921520492,"score_gpt":0.24965748363257953,"score_spread":0.23640879871105905,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2067671430","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87537634,0.05818385,0.013386226,0.00089651335,0.0010111746,0.00027875407,0.0012871437,0.0005414554,0.049038474],"genre_scores_gemma":[0.9567803,0.022380525,0.0043253065,0.0003829952,0.00028791805,0.000134052,0.00068870565,0.000054403452,0.014965817],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998772,0.000032205167,0.000008338743,0.000016528482,0.000023344557,0.00004232131],"domain_scores_gemma":[0.9999218,0.000024718729,0.000012559942,0.000007815203,0.00000877087,0.00002435382],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042405556,0.0003296165,0.00034666367,0.0002771803,0.00016674434,0.00029066947,0.00057162263,0.00028096375,0.003084189],"category_scores_gemma":[0.00026668527,0.00017781497,0.00015044342,0.00020757076,0.00020530443,0.00039133828,0.00025947273,0.0009092933,0.0007509682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003072088,0.00082173315,0.0003947305,0.00088688335,0.00005131098,0.00058061455,0.00030635085,0.0039841835,0.8775016,0.009990193,0.0046589617,0.09775138],"study_design_scores_gemma":[0.0015479848,0.019098455,0.0046931584,0.0001089578,0.0001597564,0.0011026966,0.00011554083,0.006430084,0.8541496,0.001667824,0.11081591,0.00011004112],"about_ca_topic_score_codex":0.00043991167,"about_ca_topic_score_gemma":0.0013537066,"teacher_disagreement_score":0.003084189,"about_ca_system_score_codex":0.00029972632,"about_ca_system_score_gemma":0.00020272892,"threshold_uncertainty_score":0.010317624},"labels":[],"label_agreement":null},{"id":"W2067820849","doi":"10.1016/j.bmcl.2012.06.052","title":"Non-canonical regioisomerizations and a ‘Diels–Alderase’ are likely essential in the biosynthesis of Spiculoic acid A","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"University of Ottawa; Syracuse University","keywords":"Polyketide; Chemistry; Biosynthesis; Polyene; Stereochemistry; Regioselectivity; Aldehyde; Non canonical; Natural product; Metabolite; Polyketide synthase; Chemical synthesis; Enzyme; Biochemistry; Catalysis; Biology","score_opus":0.010084469457634674,"score_gpt":0.22823854185869027,"score_spread":0.2181540724010556,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2067820849","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93424296,0.0028819889,0.041718688,0.0011641462,0.00039903563,0.000102018916,0.000712971,0.0008081216,0.017969938],"genre_scores_gemma":[0.98748267,0.00071400363,0.0075210375,0.0001940131,0.000037155143,0.000028443588,0.00066832406,0.000070996655,0.0032833503],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99972886,0.00005371235,0.000019305233,0.00007045638,0.000042087395,0.000085558226],"domain_scores_gemma":[0.99965596,0.000047110236,0.00006909439,0.00009926277,0.000063188716,0.00006540746],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005716946,0.0007320086,0.00025154077,0.0002358559,0.00037226806,0.0005839106,0.00036855924,0.00050250697,0.0037086585],"category_scores_gemma":[0.0006423374,0.00029320535,0.00041781116,0.00022757414,0.0004922201,0.001134263,0.0004675798,0.0008091539,0.0021074293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080858613,0.00011760567,0.0027827707,0.0002210383,0.000063990636,0.001482693,0.00017280932,0.0009542682,0.94435054,0.018797148,0.0011860807,0.029062502],"study_design_scores_gemma":[0.00002115263,0.00047622639,0.002835924,0.000012382554,0.00001897457,0.0010142248,0.000096642536,0.00066984317,0.9762763,0.0039653243,0.014577926,0.00003509737],"about_ca_topic_score_codex":0.000209506,"about_ca_topic_score_gemma":0.00033898832,"teacher_disagreement_score":0.0037086585,"about_ca_system_score_codex":0.00031965796,"about_ca_system_score_gemma":0.0006454724,"threshold_uncertainty_score":0.012406707},"labels":[],"label_agreement":null},{"id":"W2068154536","doi":"10.1016/j.bmcl.2011.06.095","title":"Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Bioavailability; Chemistry; Efflux; Permeability (electromagnetism); Intestinal permeability; In vivo; In vitro; Pharmacology; Oral administration; Stereochemistry; Biochemistry; Internal medicine","score_opus":0.02577879880649549,"score_gpt":0.2433645533638126,"score_spread":0.2175857545573171,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2068154536","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99744654,0.0010588776,0.0005723574,0.00009811848,0.00001792359,0.000016351738,0.00016205366,0.000041536787,0.00058631593],"genre_scores_gemma":[0.9957377,0.0014060447,0.0011487809,0.00007178495,0.000029661063,0.000019804105,0.00022697258,0.000027617874,0.0013315591],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998203,0.00004992923,0.000014097107,0.00003376738,0.000028421891,0.000053634027],"domain_scores_gemma":[0.999603,0.000104008075,0.00013781224,0.000034613346,0.000024666513,0.00009584095],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040059886,0.00035298534,0.0005065596,0.00026900426,0.00014354236,0.0004287762,0.00027927084,0.0003303848,0.0015265536],"category_scores_gemma":[0.00045609847,0.00027312784,0.00024893993,0.00013806595,0.0004487624,0.0008001663,0.00012971071,0.0010866305,0.00021401199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.011076708,0.00056193076,0.00052370614,0.00011958197,0.000040754177,0.00011300197,0.00006947589,0.00039357584,0.9750294,0.00028689505,0.00011293539,0.01167192],"study_design_scores_gemma":[0.00040794822,0.016496446,0.004173356,0.00001427651,0.00015522054,0.00022882273,0.000061976316,0.0017471216,0.9750292,0.00014279921,0.0015141779,0.000028626922],"about_ca_topic_score_codex":0.0004990063,"about_ca_topic_score_gemma":0.00077165785,"teacher_disagreement_score":0.0015265536,"about_ca_system_score_codex":0.00028919533,"about_ca_system_score_gemma":0.000260827,"threshold_uncertainty_score":0.0051068664},"labels":[],"label_agreement":null},{"id":"W2068645642","doi":"10.1016/s0960-894x(01)00238-4","title":"MEK (MAPKK) inhibitors. Part 2: structure–activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Linker; Kinase; Structure–activity relationship; Stereochemistry; Methylene; Aniline; Enzyme inhibitor; Protein kinase A; Enzyme; Biochemistry; In vitro; Medicinal chemistry; Organic chemistry","score_opus":0.016883754146990112,"score_gpt":0.2186558177986337,"score_spread":0.20177206365164357,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2068645642","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86312175,0.10633854,0.0077102934,0.0006660362,0.00032899977,0.00041317384,0.0024282786,0.00041066066,0.018582217],"genre_scores_gemma":[0.9454603,0.035881758,0.0036778199,0.00036177196,0.00010546162,0.00021944988,0.0025004917,0.000034218887,0.011758713],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999329,0.000014160707,0.000006367932,0.000008781253,0.000015973264,0.000021854195],"domain_scores_gemma":[0.99994886,0.000014490088,0.000009794709,0.0000041033095,0.000009438884,0.000013325975],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023027057,0.0004984055,0.00030493407,0.00034195947,0.00012113727,0.00016009256,0.00037628133,0.00018753223,0.0022065674],"category_scores_gemma":[0.00017693163,0.00019262143,0.00032998028,0.00018492575,0.00011033855,0.00019140428,0.0001287002,0.00048591627,0.00073824776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001607206,0.00066979113,0.00038857202,0.0005057896,0.00009407815,0.00016802445,0.00006179784,0.0021693993,0.94539744,0.0007781767,0.002262674,0.045897033],"study_design_scores_gemma":[0.0016878579,0.009297324,0.009152206,0.00006527861,0.00031148116,0.0014848483,0.00003799086,0.0025392321,0.9253301,0.0004313931,0.04959954,0.0000627925],"about_ca_topic_score_codex":0.00066297915,"about_ca_topic_score_gemma":0.0016919377,"teacher_disagreement_score":0.0022065674,"about_ca_system_score_codex":0.00032826833,"about_ca_system_score_gemma":0.00017353438,"threshold_uncertainty_score":0.0073816776},"labels":[],"label_agreement":null},{"id":"W2068864616","doi":"10.1016/j.bmcl.2012.04.022","title":"BC-spiro-estradiols. Synthesis and estrogen receptor binding affinity of four new estradiol isomers","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Chemistry; Estrogen; Estrogen receptor; Ring (chemistry); Stereochemistry; Selectivity; Ligand (biochemistry); Chemical synthesis; Receptor; Estrogen receptor beta; In vitro; Biochemistry; Internal medicine; Organic chemistry","score_opus":0.012017471258071245,"score_gpt":0.21646667424145172,"score_spread":0.20444920298338048,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2068864616","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9600975,0.007264896,0.009901368,0.00053617306,0.00020429949,0.000089256515,0.0009487504,0.00017443641,0.020783294],"genre_scores_gemma":[0.98508745,0.0027571484,0.0030411528,0.00018755242,0.000028228067,0.00003851173,0.00064638816,0.000021219026,0.008192238],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989986,0.00002115731,0.0000076075135,0.000014815666,0.000015398098,0.000041202067],"domain_scores_gemma":[0.99991834,0.0000200349,0.000010473932,0.000010469677,0.0000162847,0.000024278044],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019580983,0.0002392316,0.00018904623,0.00019217783,0.00015905107,0.00015564183,0.00045333826,0.00017669004,0.0034820242],"category_scores_gemma":[0.0002815502,0.00013423698,0.00012937348,0.00029565056,0.0001835009,0.00020424869,0.00022947146,0.00032699958,0.00095062086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016475936,0.00026109256,0.00096509774,0.00035147066,0.000029287712,0.00050569995,0.00020537646,0.0016775972,0.93928915,0.006220358,0.0015414521,0.047305856],"study_design_scores_gemma":[0.00011345824,0.0011942604,0.002244015,0.000019513536,0.000030941177,0.00041721345,0.00006884596,0.0011216347,0.9761871,0.00045811228,0.018111428,0.00003339138],"about_ca_topic_score_codex":0.0013372558,"about_ca_topic_score_gemma":0.0015088143,"teacher_disagreement_score":0.0034820242,"about_ca_system_score_codex":0.0003415724,"about_ca_system_score_gemma":0.00030617742,"threshold_uncertainty_score":0.011648476},"labels":[],"label_agreement":null},{"id":"W2068898199","doi":"10.1016/j.bmcl.2009.07.114","title":"Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Dipeptide; Moiety; Stereochemistry; Cathepsin; Chemical synthesis; Enzyme inhibitor; Cathepsin S; Combinatorial chemistry; Enzyme; Biochemistry; In vitro; Amino acid","score_opus":0.008416405383871626,"score_gpt":0.2259829509545353,"score_spread":0.21756654557066368,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2068898199","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94217604,0.008476272,0.035626516,0.00047012887,0.00023555286,0.0007792584,0.0006972148,0.00034720844,0.011191854],"genre_scores_gemma":[0.96931475,0.0050328663,0.018489877,0.00017900541,0.00003915503,0.0002476589,0.0006097306,0.000034402285,0.006052609],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999874,0.000020258647,0.000013067622,0.000019955714,0.000032850403,0.0000397516],"domain_scores_gemma":[0.999926,0.000009402983,0.000023773206,0.000008631987,0.000012246293,0.000019966841],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038170436,0.0004507255,0.00041320975,0.0002162016,0.00019967105,0.00035656334,0.00069908664,0.00047742494,0.0011478383],"category_scores_gemma":[0.00022804266,0.00032660482,0.00032137957,0.00012513725,0.00024572347,0.00035245437,0.00030737743,0.00061808014,0.00042310802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005386102,0.00019667769,0.0001314065,0.0003407952,0.00003388569,0.00045393477,0.000075364325,0.0026008976,0.96941715,0.0025819151,0.0005720512,0.02305736],"study_design_scores_gemma":[0.00024312254,0.00136647,0.00035820468,0.000016173219,0.00003319979,0.00047906736,0.00001629329,0.002326502,0.98554325,0.00021550909,0.009378047,0.00002416746],"about_ca_topic_score_codex":0.00034975304,"about_ca_topic_score_gemma":0.000780192,"teacher_disagreement_score":0.0011478383,"about_ca_system_score_codex":0.00040038527,"about_ca_system_score_gemma":0.00039577394,"threshold_uncertainty_score":0.00383991},"labels":[],"label_agreement":null},{"id":"W2068964035","doi":"10.1016/j.bmcl.2011.06.056","title":"Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"STAT3; STAT protein; Chemistry; Phosphopeptide; Phosphorylation; SH2 domain; Transcription factor; Cell biology; Molecular biology; Cancer research; Biochemistry; Biology; Proto-oncogene tyrosine-protein kinase Src; Gene","score_opus":0.02064112364897632,"score_gpt":0.2349572577010054,"score_spread":0.21431613405202907,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2068964035","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9748274,0.0021288407,0.017068107,0.00057351886,0.00010526974,0.00009127747,0.0011545649,0.00017922807,0.0038718542],"genre_scores_gemma":[0.9791628,0.00078404235,0.009028749,0.00028836087,0.000028269647,0.0000657637,0.0023944664,0.000034801324,0.008212784],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999149,0.000010943445,0.0000042720776,0.000015629666,0.000028223692,0.000025938223],"domain_scores_gemma":[0.9999207,0.000020249896,0.0000102245485,0.0000054324078,0.000009730398,0.000033506243],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014747339,0.00028370993,0.00022832112,0.0001463213,0.00021732281,0.00036686892,0.00032472023,0.0004054764,0.0023672115],"category_scores_gemma":[0.0001664019,0.00011121233,0.000260649,0.00011121615,0.0001824487,0.00020206314,0.00025475296,0.00065714243,0.0007674397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015796674,0.000028632781,0.00009936175,0.000026742775,0.000004149785,0.00008447291,0.000010803957,0.0000895106,0.9973773,0.00030670906,0.00017733667,0.001637002],"study_design_scores_gemma":[0.00004901363,0.00022066181,0.0014871629,0.0000049358273,0.000010613779,0.00057220197,0.000021705406,0.0018466089,0.9890854,0.00011354115,0.006578199,0.000009909267],"about_ca_topic_score_codex":0.0007317272,"about_ca_topic_score_gemma":0.0013053872,"teacher_disagreement_score":0.0023672115,"about_ca_system_score_codex":0.00066868734,"about_ca_system_score_gemma":0.0004307905,"threshold_uncertainty_score":0.007919073},"labels":[],"label_agreement":null},{"id":"W2069388207","doi":"10.1016/j.bmcl.2011.02.024","title":"Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Enterobacter cloacae; Chemistry; Enzyme; Linker; Ceftazidime; Lactam; Enterobacteriaceae; Stereochemistry; Microbiology; Bacteria; Biochemistry; Escherichia coli; Biology; Pseudomonas aeruginosa; Gene","score_opus":0.012962028369642652,"score_gpt":0.2187256589766611,"score_spread":0.20576363060701844,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2069388207","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9049836,0.044846106,0.02401891,0.0019617265,0.00049839856,0.00057947525,0.0015418346,0.00048691026,0.02108307],"genre_scores_gemma":[0.94602126,0.02969645,0.010009858,0.0004693027,0.00010915813,0.0001955675,0.0013677606,0.000041302555,0.012089298],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999325,0.000012290741,0.0000055170103,0.000008789813,0.000013759255,0.000027158732],"domain_scores_gemma":[0.9999608,0.0000048388397,0.00000816906,0.000002953656,0.000006145846,0.000017053553],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021014361,0.00038558824,0.00036296478,0.00018656184,0.0002118799,0.00042638282,0.00046121993,0.0003351408,0.0023287924],"category_scores_gemma":[0.00013720947,0.00021840152,0.00023973943,0.00017225985,0.00018387607,0.00038162427,0.00026151948,0.00065054925,0.0007081584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011083068,0.0004255863,0.0003404122,0.00065856875,0.00005430398,0.00068721623,0.00018585415,0.004559128,0.9326176,0.004730458,0.0022922596,0.05234035],"study_design_scores_gemma":[0.0014825336,0.009497145,0.0030180928,0.00018009494,0.0001385767,0.0013921153,0.00011221513,0.0067051146,0.8716668,0.0013992474,0.10430129,0.0001067813],"about_ca_topic_score_codex":0.00044682983,"about_ca_topic_score_gemma":0.0013050347,"teacher_disagreement_score":0.0023287924,"about_ca_system_score_codex":0.00035481586,"about_ca_system_score_gemma":0.00032845617,"threshold_uncertainty_score":0.0077905655},"labels":[],"label_agreement":null},{"id":"W2069580713","doi":"10.1016/j.bmcl.2006.02.043","title":"Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Bronchoconstriction; In vivo; Enzyme inhibitor; Enzyme; Ovalbumin; Pharmacokinetics; Pharmacology; Chemical synthesis; Stereochemistry; Structure–activity relationship; Ex vivo; In vitro; Biochemistry; Asthma; Internal medicine; Antigen; Immunology","score_opus":0.004068459440994843,"score_gpt":0.19627733384119925,"score_spread":0.1922088744002044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2069580713","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9272385,0.02786108,0.012198389,0.0007953377,0.00065506075,0.0001851777,0.00077072036,0.0007153202,0.029580439],"genre_scores_gemma":[0.97468424,0.009836804,0.004403161,0.00034489538,0.00007875712,0.00007117393,0.00059397426,0.000049897586,0.009937048],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998858,0.000028933902,0.0000072760117,0.000015781776,0.000023983686,0.000038263737],"domain_scores_gemma":[0.99995816,0.000008749092,0.000008317599,0.000005082619,0.0000062935846,0.000013365987],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039014127,0.00036676278,0.00052810647,0.00023013954,0.00018143712,0.00022260241,0.0008770725,0.0004103733,0.0025415039],"category_scores_gemma":[0.00015915559,0.0001736779,0.0002178832,0.00018044372,0.00023798083,0.00031938805,0.0003616292,0.00066879095,0.0006363119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002015069,0.0004295211,0.0003100426,0.000554929,0.00006234449,0.00071465265,0.00020374436,0.004131279,0.9280874,0.0056182174,0.0033148825,0.054557905],"study_design_scores_gemma":[0.0030029325,0.015941607,0.0050795837,0.00018596732,0.00023962422,0.002079892,0.00017210716,0.010582314,0.8452453,0.0022337434,0.11505068,0.00018630443],"about_ca_topic_score_codex":0.00079121254,"about_ca_topic_score_gemma":0.0021284544,"teacher_disagreement_score":0.0025415039,"about_ca_system_score_codex":0.00036030964,"about_ca_system_score_gemma":0.00019331544,"threshold_uncertainty_score":0.008502185},"labels":[],"label_agreement":null},{"id":"W2069681635","doi":"10.1016/j.bmcl.2013.08.070","title":"Synthesis of the non-peptidic snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT)2, its lower and higher thio homologs and their ability to modulate potassium ion channels","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"Chemistry; Thio-; Dimer; Linker; Monomer; Stereochemistry; Potassium channel; Potassium; Ring (chemistry); Ion channel; Amine gas treating; Indole test; Biophysics; Biochemistry; Organic chemistry; Receptor","score_opus":0.005866593887551093,"score_gpt":0.20129077464245235,"score_spread":0.19542418075490126,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2069681635","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98375124,0.001123411,0.012068054,0.00007264033,0.000037053345,0.000057744168,0.00039888927,0.00008753862,0.0024034018],"genre_scores_gemma":[0.9923866,0.00042972216,0.0039121574,0.000023721566,0.0000049950763,0.000018599962,0.0005712854,0.000019203679,0.0026338212],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994457,0.000008392152,0.000005824261,0.000011755662,0.000013972101,0.000015505151],"domain_scores_gemma":[0.9999311,0.0000069841553,0.000019483681,0.000010868145,0.0000105836525,0.00002104658],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000106792206,0.00021730644,0.0001618619,0.000107013315,0.00011096519,0.00013356665,0.00019194087,0.00020120837,0.0008803785],"category_scores_gemma":[0.000109529574,0.00008975685,0.00019539373,0.00013328345,0.00009718062,0.00014182781,0.00015082907,0.00033899368,0.00036519134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000058284968,0.000010236919,0.000051225757,0.000017973754,0.0000032485593,0.00004263658,0.000009978203,0.000076075296,0.9987226,0.00007286462,0.0000131511215,0.00092164514],"study_design_scores_gemma":[0.000012561192,0.00027357513,0.0006938488,0.0000017896276,0.000009483964,0.00012885878,0.0000075237567,0.00023164452,0.9971359,0.00002398513,0.0014773255,0.0000033882359],"about_ca_topic_score_codex":0.00036131093,"about_ca_topic_score_gemma":0.00044063563,"teacher_disagreement_score":0.0008803785,"about_ca_system_score_codex":0.00013150118,"about_ca_system_score_gemma":0.00020401552,"threshold_uncertainty_score":0.0029451847},"labels":[],"label_agreement":null},{"id":"W2070144900","doi":"10.1016/j.bmcl.2009.07.014","title":"Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; In vivo; Gap junction; Bioavailability; Oral administration; Pharmacology; Antiarrhythmic agent; Atrial fibrillation; Ventricular tachycardia; In vitro; Chemical synthesis; Internal medicine; Heart disease; Medicine; Biochemistry","score_opus":0.012918550418955817,"score_gpt":0.24720296163183497,"score_spread":0.23428441121287916,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2070144900","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90439165,0.043264095,0.031882115,0.0024919747,0.0007849232,0.0004182386,0.0008262059,0.0005841677,0.015356777],"genre_scores_gemma":[0.9542586,0.019620648,0.017233128,0.0008976204,0.000255693,0.00017593578,0.0006886631,0.000039265567,0.0068304455],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992025,0.000012882074,0.0000065592835,0.0000169566,0.000021040913,0.00002223489],"domain_scores_gemma":[0.9999286,0.000015886177,0.000012543806,0.000007794668,0.000011546279,0.000023694456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033466538,0.00033775717,0.00042534134,0.0002988546,0.0001913678,0.00042136214,0.0003940505,0.00038675888,0.0014834624],"category_scores_gemma":[0.00026882454,0.00015288782,0.00021360548,0.00013079886,0.00018570818,0.0003674142,0.0003087549,0.00077023485,0.0003568645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006062812,0.00028899533,0.00042987306,0.00028632526,0.000046942336,0.0006236649,0.000111455556,0.0009440637,0.8994653,0.0058036274,0.0019633372,0.089430176],"study_design_scores_gemma":[0.0007785995,0.005040667,0.003307417,0.00007664726,0.00016076368,0.0016952433,0.00007580712,0.0031484424,0.8937009,0.0024450726,0.08952185,0.00004863927],"about_ca_topic_score_codex":0.00010794205,"about_ca_topic_score_gemma":0.00033033628,"teacher_disagreement_score":0.0014834624,"about_ca_system_score_codex":0.00019324155,"about_ca_system_score_gemma":0.00013220626,"threshold_uncertainty_score":0.0049626827},"labels":[],"label_agreement":null},{"id":"W2070356768","doi":"10.1016/j.bmcl.2012.04.054","title":"Structure–activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Calgary; University of British Columbia; Celator Pharmaceuticals (Canada)","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Canada Research Chairs","keywords":"Chemistry; Pharmacology; hERG; Calcium channel; N-type calcium channel; L-type calcium channel; Potassium channel; Calcium channel blocker; Potency; Selectivity; T-type calcium channel; Calcium; Voltage-dependent calcium channel; Neuropathic pain; In vitro; Biochemistry; Internal medicine; Medicine","score_opus":0.04389644688567382,"score_gpt":0.2842731726817191,"score_spread":0.24037672579604527,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2070356768","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9860318,0.0062314896,0.0023102283,0.00016011283,0.000025810092,0.000103547114,0.0005658851,0.0000846223,0.0044864924],"genre_scores_gemma":[0.9904578,0.004710182,0.0016964126,0.00008833583,0.000015578094,0.000044666544,0.0007609144,0.000007360115,0.0022188223],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999244,0.000014260059,0.0000069191387,0.000011983989,0.000018551607,0.000023764602],"domain_scores_gemma":[0.9999207,0.000022136517,0.000024107921,0.000005057277,0.000010780146,0.00001730157],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021095303,0.00022154521,0.00024077507,0.00020971606,0.00009768168,0.00015340053,0.00023741968,0.00016071522,0.0025859675],"category_scores_gemma":[0.00024383028,0.000101016296,0.0001384608,0.00019492276,0.00010372259,0.00021523715,0.000102371865,0.00036451654,0.00043010214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009234347,0.0005823696,0.000787377,0.00021518844,0.000045242217,0.00019789541,0.00003907651,0.00301227,0.97498953,0.0003189482,0.00037960836,0.018509097],"study_design_scores_gemma":[0.00068495504,0.017126122,0.016360253,0.000036157384,0.00020634428,0.0012126324,0.000052604064,0.011227377,0.94076806,0.00031863668,0.01196181,0.00004499739],"about_ca_topic_score_codex":0.0006050694,"about_ca_topic_score_gemma":0.00204255,"teacher_disagreement_score":0.0025859675,"about_ca_system_score_codex":0.00021162328,"about_ca_system_score_gemma":0.0001717914,"threshold_uncertainty_score":0.008650959},"labels":[],"label_agreement":null},{"id":"W2071192915","doi":"10.1016/s0960-894x(01)00064-6","title":"Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; U.S. Public Health Service; University of Alberta","keywords":"Chemistry; Intracellular; Cytoplasm; In vitro; Confocal; Confocal microscopy; Fluorescence microscope; DNA; Fluorescence; Biochemistry; Biophysics; Cell biology; Stereochemistry; Molecular biology; Biology","score_opus":0.008625050237618042,"score_gpt":0.21775479001640602,"score_spread":0.209129739778788,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2071192915","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8838785,0.0022755514,0.105450325,0.00041703368,0.00012196683,0.00029284146,0.00032505664,0.00031631233,0.0069224206],"genre_scores_gemma":[0.9314607,0.0014192184,0.059794724,0.000119209144,0.000026589847,0.00014116408,0.0004183352,0.00007333617,0.0065467656],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987555,0.000021110136,0.000011164606,0.000035183275,0.000027814485,0.000029186076],"domain_scores_gemma":[0.9998275,0.000028929293,0.0000564519,0.00001941032,0.00002465018,0.000042972762],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002547945,0.00037130882,0.00020953619,0.0001555856,0.00020329784,0.0004140891,0.0003610971,0.0003424124,0.00071460084],"category_scores_gemma":[0.00026808868,0.00020717608,0.00023983225,0.00012622915,0.00031063863,0.00029807468,0.00025355132,0.0005512176,0.00042689568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005447403,0.000018320532,0.00003470442,0.00004890272,0.0000020528132,0.000047923117,0.000021350226,0.00046580916,0.9958514,0.0006967504,0.000032513537,0.0027258],"study_design_scores_gemma":[0.0000149560365,0.00016902322,0.00011235678,0.000003260211,0.000006347925,0.000079634905,0.0000073471742,0.0006368153,0.9957119,0.000047597452,0.0032062493,0.0000045316197],"about_ca_topic_score_codex":0.00064500346,"about_ca_topic_score_gemma":0.00076779013,"teacher_disagreement_score":0.00071460084,"about_ca_system_score_codex":0.0005992431,"about_ca_system_score_gemma":0.00037151572,"threshold_uncertainty_score":0.004347861},"labels":[],"label_agreement":null},{"id":"W2072586810","doi":"10.1016/s0960-894x(02)00439-0","title":"Oligonucleotides comprised of alternating 2′-Deoxy-2′-fluoro-β-d-arabinonucleosides and d-2′-deoxyribonucleosides (2′F-ANA/DNA ‘Altimers’) induce efficient RNA cleavage mediated by RNase H","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"RNase H; Oligonucleotide; RNase P; Chemistry; RNA; DNA; Molecular biology; Ribonuclease; Ribonuclease III; Nucleotide; RNase MRP; Nucleic acid; Biochemistry; Biology; Gene; RNA interference","score_opus":0.007530681494696286,"score_gpt":0.1974949652260143,"score_spread":0.18996428373131802,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2072586810","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9609535,0.0012641725,0.032477286,0.00008974443,0.00015695518,0.00017818103,0.00022128447,0.0006204478,0.0040384363],"genre_scores_gemma":[0.9704882,0.00063775363,0.023624595,0.00014239654,0.000054440272,0.00014461498,0.0004304585,0.00008666408,0.004390806],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996025,0.00009778275,0.00002935716,0.00012002917,0.00006888174,0.00008150443],"domain_scores_gemma":[0.99957544,0.00015601274,0.00011144592,0.000041401086,0.000036554975,0.000079130245],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00059032516,0.00085782586,0.0004307371,0.00027983292,0.00021919384,0.0003508678,0.00021384942,0.00065397384,0.0016402558],"category_scores_gemma":[0.00042989108,0.00048245915,0.00035321663,0.00014997677,0.0002962764,0.00028394186,0.0002380732,0.00053614145,0.0009921158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000057221285,0.00000802935,0.00002117436,0.000016273063,0.0000029945859,0.000018453007,0.000008942783,0.000032512948,0.9992962,0.000053598396,0.000011464717,0.00047324965],"study_design_scores_gemma":[0.000015204924,0.00021235552,0.0002515275,0.0000024652938,0.000006758982,0.000088637156,0.000004635392,0.00016501965,0.9985839,0.000023947161,0.00064239814,0.0000031162513],"about_ca_topic_score_codex":0.00015754664,"about_ca_topic_score_gemma":0.00037427398,"teacher_disagreement_score":0.0016402558,"about_ca_system_score_codex":0.00023464179,"about_ca_system_score_gemma":0.00019920612,"threshold_uncertainty_score":0.0054872036},"labels":[],"label_agreement":null},{"id":"W2073242886","doi":"10.1016/j.bmcl.2012.01.131","title":"N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Canada","funders":"Health Canada","keywords":"Chemistry; Bovine serum albumin; Hapten; Metabolite; Demethylation; Conjugated system; Serum albumin; Stereochemistry; Chromatography; Organic chemistry; Biochemistry; Antibody; Immunology","score_opus":0.047231008861636295,"score_gpt":0.3671906896273117,"score_spread":0.31995968076567544,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073242886","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9692606,0.0011393781,0.025346765,0.0001511843,0.00004053183,0.000080513135,0.00011976098,0.000116936964,0.0037443123],"genre_scores_gemma":[0.9929374,0.00031315972,0.003969494,0.000023956638,0.000005112321,0.000029029086,0.000097414624,0.000011312365,0.0026132162],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987257,0.00003257908,0.000009934419,0.000026504871,0.000017692222,0.000040828767],"domain_scores_gemma":[0.99994457,0.000009890993,0.000016758304,0.0000120756895,0.000008168242,0.000008387704],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025863963,0.0002776564,0.00016597594,0.00015890494,0.0001862357,0.000110478046,0.00030334192,0.00029526802,0.00075697433],"category_scores_gemma":[0.00019236226,0.00009756382,0.00021921599,0.00014046727,0.00022001944,0.00028691153,0.00026373423,0.0003141093,0.0002608193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023529088,0.000019958015,0.00013343433,0.00006008102,0.000008575162,0.00012098725,0.00005671072,0.00021776937,0.994773,0.0007196372,0.00007109307,0.0035835325],"study_design_scores_gemma":[0.000009908381,0.00014766521,0.00036119102,0.0000021564706,0.000004237606,0.000101847945,0.0000058625656,0.00024201843,0.99766386,0.000048287176,0.0014090663,0.0000039101483],"about_ca_topic_score_codex":0.0012020173,"about_ca_topic_score_gemma":0.0012752819,"teacher_disagreement_score":0.0012020173,"about_ca_system_score_codex":0.00038469984,"about_ca_system_score_gemma":0.00038303554,"threshold_uncertainty_score":0.002791226},"labels":[],"label_agreement":null},{"id":"W2073248040","doi":"10.1016/j.bmcl.2010.11.118","title":"The identification of substituted benzothiophene derivatives as PGE2 subtype 4 receptor antagonists: From acid to non-acid","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Benzothiophene; Chemistry; Antagonist; Stereochemistry; Pharmacology; Chemical synthesis; Receptor; Biochemistry; In vitro; Organic chemistry; Thiophene","score_opus":0.004908775098882982,"score_gpt":0.23492777343076357,"score_spread":0.23001899833188058,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073248040","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93061805,0.036267485,0.015948828,0.00097080594,0.00025285117,0.00030020406,0.00076204113,0.00022418791,0.014655539],"genre_scores_gemma":[0.9562012,0.024128834,0.0061432044,0.00031862638,0.00007996096,0.000082829836,0.00045628566,0.00003354277,0.012555525],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993634,0.00001585544,0.0000036788313,0.0000066683165,0.000015804744,0.00002155854],"domain_scores_gemma":[0.99994624,0.00000862752,0.0000130616145,0.000007190862,0.000012016615,0.00001282098],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017574808,0.00031900706,0.00026647255,0.00023241078,0.00017451738,0.00027911778,0.00032415544,0.0002681058,0.0029749563],"category_scores_gemma":[0.00017891891,0.00022176605,0.000201693,0.00025758785,0.00025029437,0.00032647065,0.0002497918,0.00049163983,0.00071298156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011083661,0.00012553761,0.00036415213,0.0002713936,0.000024417968,0.00040506423,0.00009943845,0.000677725,0.96231484,0.002574729,0.0007187954,0.031315517],"study_design_scores_gemma":[0.00023269567,0.003937262,0.003045322,0.000041421667,0.00008412887,0.0008287174,0.00006376049,0.0016972318,0.95277256,0.0005994465,0.03666123,0.00003616471],"about_ca_topic_score_codex":0.0006487815,"about_ca_topic_score_gemma":0.0015424319,"teacher_disagreement_score":0.0029749563,"about_ca_system_score_codex":0.00023826872,"about_ca_system_score_gemma":0.00029136284,"threshold_uncertainty_score":0.009952247},"labels":[],"label_agreement":null},{"id":"W2073353599","doi":"10.1016/j.bmcl.2009.10.078","title":"Multivalent binding oligomers inhibit HIV Tat–TAR interaction critical for viral replication","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; RNA; In vitro; tar (computing); HIV Long Terminal Repeat; Small molecule; Viral replication; Cell biology; Biochemistry; Computational biology; Combinatorial chemistry; Virology; Virus; Biology; Gene expression","score_opus":0.02012121343237762,"score_gpt":0.30823431737866286,"score_spread":0.28811310394628525,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073353599","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9934395,0.001168032,0.0020606676,0.00010088268,0.00008192628,0.000050449926,0.00014110144,0.00014780901,0.0028095096],"genre_scores_gemma":[0.9957436,0.00036542813,0.000955714,0.000084199615,0.000017321274,0.000026180294,0.00018324482,0.000027325264,0.0025969192],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997807,0.000043156797,0.000013719432,0.0000346852,0.000042500196,0.00008520657],"domain_scores_gemma":[0.99987686,0.000033364948,0.00001878408,0.00002003082,0.00001241655,0.000038459486],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017751717,0.00038691965,0.00030387714,0.0002560545,0.00037267996,0.00059410295,0.0002953964,0.0004321692,0.0036736117],"category_scores_gemma":[0.00024001044,0.00027777447,0.00022363418,0.00016778307,0.00026103697,0.00022631373,0.00036024064,0.0009822751,0.000870311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048597655,0.0002247675,0.00015125996,0.000036993122,0.000020330146,0.000031991043,0.00002913609,0.00025142587,0.9957064,0.00039434084,0.000256707,0.0024107778],"study_design_scores_gemma":[0.00007573589,0.0004749084,0.00075609196,0.0000062314652,0.000026962054,0.00013277112,0.000027436732,0.0012213021,0.99435496,0.00013049398,0.0027853947,0.000007824167],"about_ca_topic_score_codex":0.0007230134,"about_ca_topic_score_gemma":0.0012287508,"teacher_disagreement_score":0.0036736117,"about_ca_system_score_codex":0.00050766725,"about_ca_system_score_gemma":0.00026016735,"threshold_uncertainty_score":0.0122894645},"labels":[],"label_agreement":null},{"id":"W2073651377","doi":"10.1016/j.bmcl.2010.08.144","title":"Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Seaweed-derived Bioactive Compounds","field":"Agricultural and Biological Sciences","cited_by":58,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Program for New Century Excellent Talents in University","keywords":"Chemistry; Laurencia; Stereochemistry; Protein tyrosine phosphatase; Tyrosine; Two-dimensional nuclear magnetic resonance spectroscopy; Ether; Biochemistry; Algae; Botany; Organic chemistry; Biology","score_opus":0.008129010514089145,"score_gpt":0.1885767722901312,"score_spread":0.18044776177604205,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073651377","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9961572,0.0017153304,0.0007671121,0.000038980095,0.000021714402,0.0000089189025,0.00016153579,0.000035338446,0.0010938199],"genre_scores_gemma":[0.9969586,0.0006220624,0.00057204335,0.000037787948,0.0000067254814,0.000003889939,0.00028472,0.0000109114335,0.0015031416],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999373,0.000009654301,0.000004956101,0.000009110189,0.000016931097,0.000022050033],"domain_scores_gemma":[0.9999263,0.00001754422,0.00001892209,0.0000087482795,0.0000091187985,0.000019356632],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008328213,0.00033830164,0.0002210873,0.00013951217,0.0001315422,0.00020850403,0.00012650642,0.0002290828,0.0008266199],"category_scores_gemma":[0.000121363075,0.00012838775,0.0002100861,0.00010921607,0.00013520622,0.00013270213,0.00020525392,0.0002560594,0.00025436608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028592543,0.000010291122,0.00015021514,0.000019465377,0.000006054542,0.000048006197,0.000010251147,0.000046170455,0.99871635,0.000011458054,0.000014150765,0.0006815983],"study_design_scores_gemma":[0.000017144168,0.00036741697,0.0025910472,0.000003196161,0.000013281319,0.0001331737,0.000025552676,0.00015790356,0.9960032,0.000013133648,0.0006716599,0.0000032249545],"about_ca_topic_score_codex":0.001014269,"about_ca_topic_score_gemma":0.0015766638,"teacher_disagreement_score":0.001014269,"about_ca_system_score_codex":0.00014477524,"about_ca_system_score_gemma":0.00016744042,"threshold_uncertainty_score":0.0027653575},"labels":[],"label_agreement":null},{"id":"W2073860179","doi":"10.1016/j.bmcl.2010.01.098","title":"Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan; Acadia University","funders":"Vlaamse regering; Canadian Institutes of Health Research; Dalhousie University; Department of Biotechnology, Ministry of Science and Technology, India; Nova Scotia Health Research Foundation","keywords":"Pharmacophore; Chemistry; Stereochemistry; Moiety; Aryl; Cytotoxicity; Molecular model; Cytotoxic T cell; Electrophile; Chemical synthesis; Molecule; Quantitative structure–activity relationship; Structure–activity relationship; L1210 cells; In vitro; Biochemistry; Organic chemistry","score_opus":0.01417363940039979,"score_gpt":0.23660857517875192,"score_spread":0.22243493577835213,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073860179","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9835385,0.001923028,0.0047580176,0.0001554852,0.00008476755,0.00006578851,0.000294521,0.00012856734,0.009051344],"genre_scores_gemma":[0.99256104,0.001153244,0.002015083,0.00004792735,0.000021355494,0.000031998894,0.00025231708,0.000021530792,0.0038955247],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999908,0.000019090236,0.0000072582575,0.000012581683,0.000020902775,0.00003219912],"domain_scores_gemma":[0.9999118,0.000017823913,0.000025870257,0.000013290946,0.000008941801,0.000022283697],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013498131,0.00031184842,0.00029174422,0.00014166224,0.00012602049,0.00014687612,0.00036785754,0.00023268505,0.0022810684],"category_scores_gemma":[0.00015590414,0.00009446784,0.0001300906,0.00014653898,0.00015900983,0.00019827778,0.00020959892,0.0003803103,0.00047165813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004223165,0.000041720232,0.000084146755,0.00007808338,0.0000058642618,0.00018846228,0.000029722163,0.00026332593,0.9943264,0.00066231104,0.000095598705,0.0038020993],"study_design_scores_gemma":[0.00008315437,0.00096791587,0.0009943013,0.0000072325156,0.00002413049,0.0002779815,0.000012116886,0.0006463375,0.99215174,0.00009913287,0.004726567,0.000009432187],"about_ca_topic_score_codex":0.00036325608,"about_ca_topic_score_gemma":0.0006438681,"teacher_disagreement_score":0.0022810684,"about_ca_system_score_codex":0.00017797969,"about_ca_system_score_gemma":0.00015983585,"threshold_uncertainty_score":0.0076309443},"labels":[],"label_agreement":null},{"id":"W2073987498","doi":"10.1016/s0960-894x(01)00290-6","title":"Conversion of cyclic nonaketides to lovastatin and compactin by a lovc deficient mutant of Aspergillus terreus","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aspergillus terreus; Lovastatin; Chemistry; Mutant; Biosynthesis; Biochemistry; Enzyme; Gene; Cholesterol","score_opus":0.004935975415643201,"score_gpt":0.2161179683529224,"score_spread":0.2111819929372792,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073987498","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9977093,0.00025156137,0.0011234038,0.00008459957,0.00003743629,0.000013769205,0.00024147381,0.000070991344,0.00046746858],"genre_scores_gemma":[0.99700576,0.000075684235,0.00087710685,0.000022789505,0.000007560174,0.000008633398,0.0004296131,0.000045166922,0.0015277552],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99971074,0.00003959371,0.000051096653,0.000048112048,0.00009623084,0.00005420987],"domain_scores_gemma":[0.9995695,0.00009268816,0.00013842221,0.00008635343,0.00003291216,0.00008012562],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017296973,0.0005384383,0.00044370355,0.00035291017,0.0002068731,0.0005523607,0.00059805973,0.0004883352,0.0010126281],"category_scores_gemma":[0.00028802725,0.00024105966,0.0004289886,0.00025661418,0.00031698524,0.0002580817,0.00046912426,0.00064388197,0.00049381016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015545197,0.00003939354,0.0001552878,0.000014344888,0.000008995398,0.00022555768,0.000021381793,0.00013258563,0.9985286,0.00012400403,0.000019684518,0.00057458825],"study_design_scores_gemma":[0.000020706524,0.00016928169,0.0020597759,0.0000046189593,0.000015614998,0.00058591214,0.00008181869,0.0012975638,0.9948285,0.00008198787,0.0008382749,0.00001584593],"about_ca_topic_score_codex":0.003324731,"about_ca_topic_score_gemma":0.0015524855,"teacher_disagreement_score":0.003324731,"about_ca_system_score_codex":0.00040620237,"about_ca_system_score_gemma":0.00031204143,"threshold_uncertainty_score":0.006610751},"labels":[],"label_agreement":null},{"id":"W2074993066","doi":"10.1016/j.bmcl.2009.04.086","title":"Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Lycorine; Chemistry; Amaryllidaceae Alkaloids; CYP3A4; Amaryllidaceae; Inhibitory postsynaptic potential; Stereochemistry; Alkaloid; Biological activity; Cytochrome P450; Biochemistry; Enzyme; In vitro","score_opus":0.0068173650958167145,"score_gpt":0.21123512891640114,"score_spread":0.20441776382058444,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2074993066","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9891533,0.0043230588,0.0013881845,0.00011959842,0.00004385219,0.000034184934,0.0002840908,0.00007248576,0.0045812186],"genre_scores_gemma":[0.9939599,0.0018830184,0.001255433,0.000059647333,0.000022678732,0.000015956908,0.00035989756,0.000013785261,0.0024297684],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999262,0.000018604582,0.000006580098,0.000011971925,0.000017603195,0.000018958575],"domain_scores_gemma":[0.9999474,0.000011065699,0.00000997634,0.0000065249224,0.000012662409,0.000012357919],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009893144,0.0002298102,0.0002492677,0.0002486771,0.00018388993,0.00015263671,0.00018943578,0.00017208025,0.0015585723],"category_scores_gemma":[0.00014738426,0.000117014366,0.00014774968,0.00014431751,0.00009497918,0.000108329135,0.00015914315,0.00034913624,0.00032230405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031987,0.000030933086,0.00015559915,0.000051811872,0.000009455127,0.000057144745,0.000013808522,0.00005713788,0.9942139,0.000076286604,0.00008027558,0.0049337503],"study_design_scores_gemma":[0.00007583441,0.00093596074,0.0030461547,0.00000791648,0.00002967272,0.0002530228,0.000014404318,0.00038691278,0.9920449,0.000037881113,0.0031620055,0.00000534628],"about_ca_topic_score_codex":0.0007372346,"about_ca_topic_score_gemma":0.0015387096,"teacher_disagreement_score":0.0015585723,"about_ca_system_score_codex":0.00013787691,"about_ca_system_score_gemma":0.00013685093,"threshold_uncertainty_score":0.0052139163},"labels":[],"label_agreement":null},{"id":"W2075107394","doi":"10.1016/j.bmcl.2012.05.073","title":"Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Chemistry; Betulinic acid; Betulin; Moiety; Cytotoxicity; Stereochemistry; Triterpene; Diterpene; In vitro; Chemical synthesis; Cytotoxic T cell; Terpene; Cell culture; Structure–activity relationship; Biological activity; Biochemistry","score_opus":0.010014885972838582,"score_gpt":0.2233544858973242,"score_spread":0.21333959992448562,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2075107394","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.985314,0.0036341005,0.0042806426,0.00011954267,0.000039905688,0.000055406726,0.00062468555,0.0000797936,0.0058518937],"genre_scores_gemma":[0.9922261,0.0020494298,0.0016654908,0.000026351036,0.00000849263,0.000022628768,0.00053272606,0.000016274163,0.0034525061],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999936,0.000013567187,0.000010108657,0.000008563265,0.000012908657,0.000018923174],"domain_scores_gemma":[0.9999306,0.000015150517,0.000013296421,0.000015782813,0.000009277441,0.000015835749],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414966,0.0003130208,0.00016545592,0.00028626423,0.00012870657,0.00020472523,0.00020400445,0.00019543231,0.0016116688],"category_scores_gemma":[0.00012061432,0.00008605291,0.00022724955,0.00020182766,0.00012610524,0.00025787164,0.00023860949,0.0002474517,0.00052409706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00041105255,0.00004247338,0.00014678443,0.000062918065,0.000008589514,0.00033797155,0.000031634594,0.0005514231,0.991021,0.00035854898,0.00006385222,0.0069637042],"study_design_scores_gemma":[0.000011238603,0.00016635013,0.00021641963,0.000002797888,0.000007089734,0.00008704489,0.000007617919,0.000108451204,0.99801105,0.00003891185,0.0013405667,0.0000025141414],"about_ca_topic_score_codex":0.00029198045,"about_ca_topic_score_gemma":0.000382062,"teacher_disagreement_score":0.0016116688,"about_ca_system_score_codex":0.00014704105,"about_ca_system_score_gemma":0.00019934596,"threshold_uncertainty_score":0.0053915977},"labels":[],"label_agreement":null},{"id":"W2075151899","doi":"10.1016/j.bmcl.2009.06.077","title":"Synthesis and structure–activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Antimicrobial; Selectivity; Indole test; Antibacterial activity; In vitro; Ether; Chemical synthesis; Stereochemistry; Structure–activity relationship; Antibacterial agent; Staphylococcus aureus; Combinatorial chemistry; Diphenyl ether; Antibiotics; Bacteria; Organic chemistry; Biochemistry","score_opus":0.02017982199546528,"score_gpt":0.2384293358233705,"score_spread":0.21824951382790522,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2075151899","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96855766,0.01584329,0.004488114,0.00034889905,0.00013334758,0.00022064804,0.00092960324,0.00006208754,0.009416382],"genre_scores_gemma":[0.98328626,0.0068961885,0.0046589063,0.00016016176,0.00004704626,0.000061490464,0.0005897084,0.000011461071,0.0042888434],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999237,0.000014269382,0.000010682422,0.000011199353,0.000015544982,0.000024575582],"domain_scores_gemma":[0.9999249,0.000013132553,0.000018222838,0.000009293806,0.00001415838,0.000020200698],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026928014,0.00030132223,0.00029946756,0.00025765464,0.000117371754,0.00021961454,0.0003312695,0.00022269604,0.0019886522],"category_scores_gemma":[0.0001767883,0.00017348194,0.00019321796,0.00019191872,0.00013300541,0.00026940362,0.00017769971,0.00037343818,0.00039075728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00094144116,0.00025239808,0.00025079263,0.00029126878,0.000034343568,0.00027870433,0.00006607339,0.0018919966,0.9673716,0.0011250358,0.00056303525,0.02693331],"study_design_scores_gemma":[0.00034799994,0.0046887007,0.0023478316,0.000023765675,0.0000792852,0.0005999762,0.00002609019,0.0022598696,0.97019887,0.00022272504,0.01917509,0.000029758387],"about_ca_topic_score_codex":0.00035247137,"about_ca_topic_score_gemma":0.0008877995,"teacher_disagreement_score":0.0019886522,"about_ca_system_score_codex":0.00026842038,"about_ca_system_score_gemma":0.00019843644,"threshold_uncertainty_score":0.006652713},"labels":[],"label_agreement":null},{"id":"W2075447609","doi":"10.1016/s0960-894x(00)00141-4","title":"Pyrrolo[3,2,1- ij ]quinoline derivatives, a 5-HT 2c receptor agonist with selectivity over the 5-HT 2a receptor: potential therapeutic applications for epilepsy and obesity","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Chemistry; Selectivity; Agonist; Receptor; Epilepsy; Quinoline; 5-HT receptor; Pharmacology; Stereochemistry; Biochemistry; Serotonin; Organic chemistry; Neuroscience; Medicine","score_opus":0.006386308425873393,"score_gpt":0.21169641040987985,"score_spread":0.20531010198400645,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2075447609","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8909964,0.06811059,0.015275099,0.0019019516,0.00036561582,0.00011245012,0.00038099912,0.00030604185,0.02255081],"genre_scores_gemma":[0.97663194,0.013911005,0.0026195846,0.0003787701,0.00010707181,0.000026034311,0.000120489276,0.00001239587,0.0061926823],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99997044,0.000006993721,0.0000012741493,0.0000058671158,0.000005650465,0.000009786134],"domain_scores_gemma":[0.99997115,0.0000066139028,0.000011065539,0.0000024216695,0.0000035198202,0.0000051230472],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008813148,0.00015195984,0.00013799054,0.000105616935,0.00014002541,0.00015002755,0.00021998254,0.00022652507,0.0023310957],"category_scores_gemma":[0.00007555055,0.000088163,0.00009022832,0.00007788024,0.00015624941,0.00019307247,0.0000959828,0.00029823498,0.00034679225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00062400365,0.0001110062,0.00032565236,0.00037305368,0.000015974521,0.000806256,0.00006620655,0.0006685649,0.95557284,0.0041111135,0.0011139003,0.03621148],"study_design_scores_gemma":[0.0006037109,0.006512776,0.015689773,0.00007409528,0.00011492882,0.004979554,0.000106107145,0.004902692,0.8915636,0.002164944,0.07320842,0.00007945164],"about_ca_topic_score_codex":0.00043751748,"about_ca_topic_score_gemma":0.0010472818,"teacher_disagreement_score":0.0023310957,"about_ca_system_score_codex":0.00011694934,"about_ca_system_score_gemma":0.00010572274,"threshold_uncertainty_score":0.007798314},"labels":[],"label_agreement":null},{"id":"W2075497492","doi":"10.1016/j.bmcl.2014.07.083","title":"Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Chemistry; Bioisostere; Natural product; Triazole; Aromatase; Cytochrome P450; 1,2,3-Triazole; Aryl; Stereochemistry; Potency; Structure–activity relationship; Biochemistry; Enzyme; Chemical synthesis; Combinatorial chemistry; In vitro; Organic chemistry","score_opus":0.006986887618705998,"score_gpt":0.2212685490553013,"score_spread":0.2142816614365953,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2075497492","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91142637,0.033288952,0.022966327,0.0013747951,0.00052104954,0.00077432743,0.0018284812,0.0012913219,0.02652836],"genre_scores_gemma":[0.95977783,0.012712788,0.0083773555,0.00044672325,0.00007367746,0.00014600763,0.0017024598,0.00003940219,0.016723678],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987376,0.000009550113,0.0000055642613,0.000022954013,0.000035856858,0.000052210245],"domain_scores_gemma":[0.9999393,0.000005777043,0.000010968036,0.00000614405,0.000015347438,0.000022359862],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022957215,0.00051014096,0.00033966266,0.0004207663,0.00023710592,0.0005092252,0.0006798378,0.00053350284,0.002578394],"category_scores_gemma":[0.00019004186,0.00018122222,0.00032600784,0.00037409845,0.00026192798,0.00028711674,0.00028659793,0.00074514444,0.00061631715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044222758,0.00024867404,0.000566803,0.0002451014,0.00005033623,0.0006220902,0.000082387705,0.00062385923,0.94660443,0.0018626059,0.0024518955,0.04619954],"study_design_scores_gemma":[0.00044643038,0.0030277972,0.0045653516,0.0000290944,0.00015713848,0.0018809813,0.00004160187,0.0026522684,0.91975147,0.00027813736,0.06712726,0.00004244894],"about_ca_topic_score_codex":0.002968398,"about_ca_topic_score_gemma":0.012167035,"teacher_disagreement_score":0.002968398,"about_ca_system_score_codex":0.0007290905,"about_ca_system_score_gemma":0.00048654055,"threshold_uncertainty_score":0.008625627},"labels":[],"label_agreement":null},{"id":"W2075525534","doi":"10.1016/s0960-894x(00)00580-1","title":"Synthesis and Structure–Activity Relationships of 3-Cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) Inhibitors","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Kinase; Enzyme inhibitor; Alkoxy group; Mitogen-activated protein kinase; Structure–activity relationship; IC50; Inhibitory postsynaptic potential; Stereochemistry; Mitogen-activated protein kinase kinase; Enzyme; Protein kinase A; Biochemistry; In vitro; Organic chemistry; Endocrinology; Biology","score_opus":0.008896503226833899,"score_gpt":0.20487395553096968,"score_spread":0.19597745230413577,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2075525534","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9454013,0.025358183,0.0151073085,0.0004469911,0.00017716907,0.0004920861,0.0009760009,0.0002811743,0.011759908],"genre_scores_gemma":[0.98488945,0.006989844,0.004191703,0.00009236467,0.00002903533,0.00008734801,0.0004916193,0.000021604961,0.0032071606],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989367,0.000028070197,0.000009184831,0.000015334826,0.000020095255,0.000033654247],"domain_scores_gemma":[0.9999039,0.0000202389,0.000020087911,0.000008946489,0.000020776746,0.000026059928],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034991794,0.0003702911,0.0003146965,0.00035650947,0.0001960796,0.0002319271,0.0006800499,0.00030372565,0.0018760291],"category_scores_gemma":[0.0002280159,0.00023244688,0.00026598418,0.00020434141,0.00016969998,0.00025687684,0.00020199957,0.00042900065,0.00056848646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00086583674,0.00041766776,0.00029652083,0.00033912444,0.00004009006,0.0003832689,0.00011278847,0.0026474409,0.97448653,0.0012705402,0.00061180553,0.018528415],"study_design_scores_gemma":[0.00057210587,0.004796275,0.0034661707,0.00004289657,0.000100757774,0.00065912626,0.000054727112,0.003846329,0.9684683,0.0003379322,0.017605975,0.000049492442],"about_ca_topic_score_codex":0.00095307577,"about_ca_topic_score_gemma":0.0020480684,"teacher_disagreement_score":0.0018760291,"about_ca_system_score_codex":0.0002923961,"about_ca_system_score_gemma":0.00023443559,"threshold_uncertainty_score":0.006275952},"labels":[],"label_agreement":null},{"id":"W2075935155","doi":"10.1016/j.bmcl.2009.10.136","title":"Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Benzimidazole; NS5B; Linker; Stereochemistry; Allosteric regulation; AutoDock; Combinatorial chemistry; Drug discovery; Lipophilicity; Polymerase; Enzyme; Biochemistry; Organic chemistry","score_opus":0.019853275390358065,"score_gpt":0.2821290865019598,"score_spread":0.2622758111116017,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2075935155","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.915651,0.0032282253,0.06980179,0.00028490208,0.00007724861,0.0005574741,0.0005054267,0.00076420465,0.009129661],"genre_scores_gemma":[0.9492877,0.0012821201,0.046641838,0.00009916355,0.000010504062,0.0000916085,0.00027244881,0.000040200423,0.0022743652],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988604,0.000017701524,0.0000074994728,0.000025614645,0.000036616828,0.000026486101],"domain_scores_gemma":[0.9999454,0.00001109609,0.000015616686,0.0000079610245,0.0000071530803,0.000012719061],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030439266,0.00031702485,0.00038369538,0.00015650022,0.00018129342,0.00039706242,0.00042273288,0.00023324479,0.0014328443],"category_scores_gemma":[0.0002787088,0.00021791685,0.00019666698,0.00016679506,0.00013197464,0.0002753282,0.00032363913,0.0004623968,0.0003223535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00059440656,0.00021110804,0.00042038257,0.00024436796,0.000024111145,0.00023974822,0.00008330908,0.008012196,0.9153119,0.0020201798,0.00052793196,0.072310306],"study_design_scores_gemma":[0.00024621366,0.0011811096,0.00040341183,0.000013795715,0.00003590314,0.00028429457,0.000024525225,0.014752863,0.9760325,0.00031282307,0.0066927783,0.000019661855],"about_ca_topic_score_codex":0.0005813573,"about_ca_topic_score_gemma":0.0023200645,"teacher_disagreement_score":0.0014328443,"about_ca_system_score_codex":0.0004634256,"about_ca_system_score_gemma":0.00041926044,"threshold_uncertainty_score":0.0047932863},"labels":[],"label_agreement":null},{"id":"W2076031937","doi":"10.1016/s0960-894x(00)00466-2","title":"NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Tetrapeptide; NS3; Two-dimensional nuclear magnetic resonance spectroscopy; Protease inhibitor (pharmacology); Protease; Stereochemistry; Hepatitis C virus; Serine protease; Amino acid; Biochemistry; Enzyme; Peptide; Virus; Virology","score_opus":0.016052064841315546,"score_gpt":0.2693932170107473,"score_spread":0.25334115216943176,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076031937","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.973424,0.0024666053,0.0192316,0.00034186736,0.00005808955,0.000104816274,0.000172134,0.00018066484,0.004020186],"genre_scores_gemma":[0.97642857,0.0016345073,0.019073427,0.00017244644,0.000027071752,0.00007299579,0.00019546426,0.000028198236,0.0023673836],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984837,0.000044473265,0.000004637616,0.000018869077,0.00004867237,0.00003493674],"domain_scores_gemma":[0.9998759,0.00003493274,0.000025903471,0.000016281245,0.000019793546,0.000027192546],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006897604,0.00032966112,0.00026467885,0.0002963513,0.00027819164,0.00027157372,0.00042669632,0.00049061765,0.00089976523],"category_scores_gemma":[0.00037267586,0.00020341125,0.00021425186,0.00030428648,0.0004461933,0.00041258178,0.0002918914,0.0007234052,0.0001329382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036770813,0.000079586105,0.000202408,0.000050859675,0.000015827896,0.000059371458,0.000031447013,0.0007127939,0.99223703,0.00039183148,0.000099211196,0.0057518813],"study_design_scores_gemma":[0.0001271394,0.0009237331,0.0015653424,0.000007504469,0.000039957496,0.0001700909,0.000020332836,0.0064203152,0.9887672,0.00017810863,0.0017617939,0.0000183807],"about_ca_topic_score_codex":0.0007288842,"about_ca_topic_score_gemma":0.0012951333,"teacher_disagreement_score":0.00089976523,"about_ca_system_score_codex":0.0003232198,"about_ca_system_score_gemma":0.0002855057,"threshold_uncertainty_score":0.0036478639},"labels":[],"label_agreement":null},{"id":"W2076333965","doi":"10.1016/j.bmcl.2010.12.090","title":"6″-Azido-6″-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Glycosyltransferase; Cycloaddition; Glycoconjugate; Azide; Glycosyl; Glycosylation; Stereochemistry; Substrate (aquarium); Nucleotide sugar; Click chemistry; Combinatorial chemistry; Enzyme; Biochemistry; Catalysis; Organic chemistry","score_opus":0.005347342086203782,"score_gpt":0.24293654410368543,"score_spread":0.23758920201748165,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076333965","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9388856,0.0053132568,0.038891327,0.000544715,0.0003878619,0.00014552438,0.0007990373,0.00054504914,0.014487613],"genre_scores_gemma":[0.95735306,0.0032349278,0.024628283,0.000083572784,0.000031005293,0.000053739208,0.0015702202,0.00005565157,0.0129895145],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99973196,0.00007834377,0.0000178322,0.00005179417,0.000059104055,0.00006089125],"domain_scores_gemma":[0.9999075,0.0000118115495,0.0000088465595,0.000012733532,0.00001904264,0.00004004039],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031947638,0.00060261454,0.00039302802,0.00022520903,0.00022018314,0.0006480733,0.00040081659,0.00049692823,0.0007703104],"category_scores_gemma":[0.00016318081,0.00020166684,0.00025384958,0.00045103108,0.00020653883,0.00039953119,0.00030955777,0.0007832809,0.0011727314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028061602,0.000042692616,0.00029926884,0.00006468785,0.0000116501615,0.00026001595,0.000033673325,0.0003392111,0.99295145,0.00088608795,0.00019065654,0.0046400707],"study_design_scores_gemma":[0.000011668061,0.00014022875,0.00040980396,0.0000049375917,0.000011314758,0.00023103546,0.000019263196,0.0007494781,0.993317,0.00007926514,0.005019776,0.000006066325],"about_ca_topic_score_codex":0.0012303126,"about_ca_topic_score_gemma":0.0010383406,"teacher_disagreement_score":0.0012303126,"about_ca_system_score_codex":0.00064801035,"about_ca_system_score_gemma":0.0004785656,"threshold_uncertainty_score":0.0047016144},"labels":[],"label_agreement":null},{"id":"W2076353778","doi":"10.1016/j.bmcl.2011.09.012","title":"A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Galactitol; Chemistry; Fluorescence; Mutant; Biochemistry; Stereochemistry; Galactose","score_opus":0.021904001103317867,"score_gpt":0.2390279318560831,"score_spread":0.21712393075276523,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076353778","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8721694,0.0051673455,0.09771349,0.0012849305,0.00025102726,0.00025479952,0.0012229059,0.0009582953,0.020977879],"genre_scores_gemma":[0.93139094,0.0032863857,0.052948963,0.0003534586,0.00006927068,0.00021329061,0.0020307875,0.00010190981,0.009605073],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999848,0.000034412114,0.000007930425,0.00003461371,0.000027963539,0.000046905654],"domain_scores_gemma":[0.99984825,0.000052819196,0.000023499051,0.00001984861,0.000017773558,0.000037834314],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027348456,0.00060197245,0.00032754245,0.000492985,0.00038341584,0.00034607822,0.0006043668,0.0006757756,0.0018055694],"category_scores_gemma":[0.00021555589,0.00027464653,0.00024738826,0.00039762058,0.0004109931,0.00036487848,0.000362083,0.0009177134,0.0009641489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009027209,0.000016775804,0.00006405115,0.000059284772,0.00000381869,0.00009992143,0.000030789433,0.000080453305,0.9963618,0.0009592559,0.00014579316,0.0020878173],"study_design_scores_gemma":[0.000016621876,0.00009576228,0.00052469026,0.000006868403,0.000011194138,0.00053440774,0.00001889794,0.00059261994,0.99271727,0.00011018577,0.0053655338,0.0000058850624],"about_ca_topic_score_codex":0.00065970706,"about_ca_topic_score_gemma":0.0005653118,"teacher_disagreement_score":0.0018055694,"about_ca_system_score_codex":0.0007538361,"about_ca_system_score_gemma":0.00040822092,"threshold_uncertainty_score":0.006040275},"labels":[],"label_agreement":null},{"id":"W2076929684","doi":"10.1016/j.bmcl.2014.05.095","title":"Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal","keywords":"Chemistry; Apoptosis; Caspase; Cancer cell; Caspase 8; Caspase 3; Chemical synthesis; Stereochemistry; Cancer; In vitro; Cell biology; Cancer research; Programmed cell death; Biochemistry; Internal medicine","score_opus":0.008187057392439486,"score_gpt":0.21137830758196435,"score_spread":0.20319125018952486,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076929684","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.898291,0.014566911,0.071542494,0.00068953633,0.00033355504,0.0009406308,0.0011186913,0.0004914083,0.012025723],"genre_scores_gemma":[0.9629645,0.00666073,0.024534868,0.00018040434,0.000050745137,0.0002578496,0.00064436556,0.000037508365,0.004669038],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998958,0.000016196267,0.00001394626,0.000019841926,0.00002376909,0.000030436837],"domain_scores_gemma":[0.99994004,0.000010179708,0.00001652752,0.0000055208097,0.0000116576975,0.00001604287],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019957779,0.00038110022,0.0004221174,0.00021878876,0.00018937838,0.00036487536,0.00044979563,0.00033205774,0.0014351924],"category_scores_gemma":[0.00015169563,0.00021395771,0.00026783216,0.00024190695,0.00014267232,0.00033735653,0.00023879431,0.00076758565,0.0005543737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006109447,0.00012583272,0.00014039999,0.0003091787,0.000028662593,0.00051164185,0.000073570045,0.002057762,0.9749918,0.0017541274,0.00035012022,0.019046027],"study_design_scores_gemma":[0.00020099596,0.0009327514,0.0002027034,0.000012303737,0.000033488814,0.00039316408,0.000016976617,0.0015435134,0.9866238,0.00025818485,0.009768805,0.000013377391],"about_ca_topic_score_codex":0.00019505978,"about_ca_topic_score_gemma":0.00038423456,"teacher_disagreement_score":0.0014351924,"about_ca_system_score_codex":0.00035753427,"about_ca_system_score_gemma":0.00028869451,"threshold_uncertainty_score":0.0048012137},"labels":[],"label_agreement":null},{"id":"W2077475587","doi":"10.1016/j.bmcl.2012.01.093","title":"Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Cyclooxygenase; Potency; Sodium azide; Stereochemistry; IC50; Meloxicam; Sulfonamide; Azide; Sulfone; Pharmacology; Enzyme inhibitor; In vitro; Enzyme; Biochemistry; Organic chemistry","score_opus":0.011046683884132857,"score_gpt":0.2385045740385707,"score_spread":0.22745789015443785,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2077475587","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.76396567,0.1556438,0.032871313,0.0024191444,0.003104999,0.00046906,0.0018298785,0.0012957728,0.038400352],"genre_scores_gemma":[0.9373402,0.038787764,0.009571445,0.0006119299,0.00021732828,0.00021123928,0.0008957059,0.000055486642,0.012308906],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986386,0.000029241957,0.000011243415,0.00001752433,0.000024957597,0.000053211756],"domain_scores_gemma":[0.9999485,0.0000071065056,0.000014354646,0.000006409438,0.000009184336,0.000014525294],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003086095,0.0006661323,0.0005937911,0.00039139873,0.00034385882,0.00040775185,0.00089625036,0.0005718082,0.002995649],"category_scores_gemma":[0.00017653308,0.00032677548,0.00041422294,0.00029963662,0.00028684534,0.0005473408,0.00034158412,0.00094551546,0.0010568656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018683072,0.00045651244,0.0003612103,0.0011242346,0.000099049044,0.0011106776,0.00022490193,0.0020560974,0.9222849,0.0060139457,0.005185062,0.059215203],"study_design_scores_gemma":[0.0014419814,0.009425974,0.0040542623,0.00020404345,0.00034137137,0.0022883439,0.00014625503,0.0050240685,0.8658568,0.001402744,0.10966935,0.00014477805],"about_ca_topic_score_codex":0.00042732788,"about_ca_topic_score_gemma":0.001624547,"teacher_disagreement_score":0.002995649,"about_ca_system_score_codex":0.0004642352,"about_ca_system_score_gemma":0.0002960923,"threshold_uncertainty_score":0.0100213885},"labels":[],"label_agreement":null},{"id":"W2077509246","doi":"10.1016/s0960-894x(03)00728-5","title":"Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cytisine; Chemistry; Nicotinic agonist; Acetylcholine receptor; Steric effects; Stereochemistry; Receptor; Conformational isomerism; Nicotinic acetylcholine receptor; Binding site; Nicotine; Acetylcholine; Biochemistry; Pharmacology; Molecule; Neuroscience","score_opus":0.01982314838355568,"score_gpt":0.2773895054634994,"score_spread":0.2575663570799437,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2077509246","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9975198,0.0002267599,0.00095808884,0.00006508991,0.000010737742,0.000012146516,0.000043011343,0.000028678278,0.0011356403],"genre_scores_gemma":[0.99895334,0.00011253641,0.00043330353,0.000032689455,0.0000033148378,0.000007960532,0.000087833134,0.000015110816,0.00035394894],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998267,0.00003905904,0.000016255388,0.000024375924,0.00004128503,0.000052365158],"domain_scores_gemma":[0.99968565,0.000138591,0.000045984536,0.00004810928,0.000023864157,0.00005785912],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020145372,0.00023101212,0.00033618064,0.000091655456,0.00027036184,0.00049063377,0.00043809402,0.00035631497,0.0026428227],"category_scores_gemma":[0.0008488258,0.00025859624,0.00020698042,0.000083628234,0.00029747534,0.00036315914,0.00032067043,0.0006845983,0.00038391928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008703987,0.000057264115,0.0003458158,0.00005984859,0.000020621057,0.00028369116,0.000085845975,0.0024994577,0.99216425,0.0014650912,0.000099986944,0.0020478184],"study_design_scores_gemma":[0.0000938104,0.00065504486,0.0021674715,0.000012537826,0.000043273714,0.0005594422,0.00018218845,0.008169369,0.9852704,0.0010304222,0.0017655666,0.000050508457],"about_ca_topic_score_codex":0.00060471107,"about_ca_topic_score_gemma":0.0008758769,"teacher_disagreement_score":0.0026428227,"about_ca_system_score_codex":0.00030235387,"about_ca_system_score_gemma":0.00020032514,"threshold_uncertainty_score":0.008841097},"labels":[],"label_agreement":null},{"id":"W2077715783","doi":"10.1016/j.bmcl.2008.12.045","title":"Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre; Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; HDAC6; Moiety; Gene isoform; Selectivity; Histone deacetylase; Stereochemistry; Piperazine; Small molecule; Biochemistry; Histone; Gene; Organic chemistry; Catalysis","score_opus":0.015080435497990458,"score_gpt":0.24789012986160378,"score_spread":0.23280969436361332,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2077715783","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82800984,0.019555787,0.06502649,0.0018816032,0.0015311061,0.0006006686,0.0027391857,0.0019619858,0.07869329],"genre_scores_gemma":[0.95462275,0.008086347,0.016014159,0.00056067423,0.0001536912,0.00013834443,0.0010481474,0.00010499166,0.01927071],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999008,0.000011793912,0.000005885446,0.000016690106,0.00002324414,0.000041653446],"domain_scores_gemma":[0.99995565,0.000005078372,0.000009456708,0.0000048406246,0.0000069084094,0.000018052877],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024470573,0.00052486744,0.00045727493,0.00025888905,0.0002160489,0.00034028545,0.0006254998,0.00028016182,0.0041103647],"category_scores_gemma":[0.000114949486,0.00018003452,0.00021044296,0.00026347133,0.00018154822,0.00030011148,0.0003043375,0.0007661526,0.0010996667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008748532,0.00023609391,0.0003381931,0.00027739795,0.000049308488,0.000340372,0.00005036538,0.0014469555,0.92999583,0.0060638045,0.0034142453,0.056912586],"study_design_scores_gemma":[0.00034051307,0.0010450251,0.0005584496,0.000011051704,0.000046140998,0.0004837253,0.000019688476,0.0025908747,0.96333176,0.0005067914,0.031039478,0.000026618876],"about_ca_topic_score_codex":0.00054514356,"about_ca_topic_score_gemma":0.0019680236,"teacher_disagreement_score":0.0041103647,"about_ca_system_score_codex":0.00049962936,"about_ca_system_score_gemma":0.00026286012,"threshold_uncertainty_score":0.013750553},"labels":[],"label_agreement":null},{"id":"W2078058404","doi":"10.1016/j.bmcl.2004.06.066","title":"Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"ConjuChem (Canada)","funders":"","keywords":"Bioconjugation; Chemistry; Human serum albumin; Amide; Albumin; Bovine serum albumin; Lysine; In vitro; Biological activity; Alanine; Combinatorial chemistry; Biochemistry; Stereochemistry; Amino acid","score_opus":0.0068068961429652184,"score_gpt":0.24074351385411802,"score_spread":0.2339366177111528,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078058404","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99067897,0.00059059035,0.007476324,0.00012694135,0.00003362774,0.000039833627,0.000121914156,0.000059366255,0.0008724037],"genre_scores_gemma":[0.9903831,0.000247104,0.0057631284,0.00008015609,0.000008442817,0.000023309585,0.00038948245,0.000028895653,0.0030763561],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998472,0.000026599993,0.00001139451,0.00003139031,0.000034470584,0.000048914284],"domain_scores_gemma":[0.99989605,0.000015406778,0.000020551886,0.000011198243,0.000021512942,0.000035409157],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025894388,0.00033525456,0.00030163696,0.0002043161,0.00018324301,0.0003442844,0.0002730661,0.00040365118,0.0007233535],"category_scores_gemma":[0.00023333023,0.00013462269,0.00027868248,0.00016009898,0.00021997016,0.0001489799,0.00025285556,0.0004582085,0.00030780467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011911426,0.000017234594,0.000049919483,0.000011121135,0.0000033149831,0.000043717253,0.000009225981,0.000068819936,0.9985989,0.000055370667,0.000019501938,0.0010036461],"study_design_scores_gemma":[0.000013133718,0.0001586947,0.0005740218,0.0000016707015,0.000008864888,0.00008959533,0.000005473956,0.00054054905,0.9977825,0.000015147787,0.0008073393,0.000003045957],"about_ca_topic_score_codex":0.00085788313,"about_ca_topic_score_gemma":0.0007990325,"teacher_disagreement_score":0.00085788313,"about_ca_system_score_codex":0.00049957004,"about_ca_system_score_gemma":0.0002132213,"threshold_uncertainty_score":0.0036246777},"labels":[],"label_agreement":null},{"id":"W2078414097","doi":"10.1016/s0960-894x(00)00295-x","title":"Phenyl sulfur mustard derivatives of distamycin A","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre","funders":"","keywords":"Nitrogen mustard; Chemistry; Sulfoxide; Sulfur mustard; Sulfone; Sulfur; Melphalan; Stereochemistry; Chemical synthesis; Dimethyl sulfoxide; Organic chemistry; Biochemistry; Toxicity; In vitro; Chemotherapy","score_opus":0.0158096316303245,"score_gpt":0.22903125762139184,"score_spread":0.21322162599106734,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078414097","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99125504,0.0016804343,0.0013482936,0.00014887525,0.00007977324,0.000057232537,0.00027218685,0.000075638796,0.0050826357],"genre_scores_gemma":[0.9953715,0.00086129515,0.00082224206,0.00004099928,0.000013113832,0.000017128523,0.00023085631,0.000009869845,0.0026328387],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998566,0.00003949426,0.000012894602,0.000015757101,0.000030372752,0.00004486439],"domain_scores_gemma":[0.99984884,0.000036135527,0.000023692068,0.000016831513,0.00002026351,0.000054218137],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016525206,0.00031980642,0.00028906853,0.00031503508,0.00022333565,0.00013067295,0.00027051216,0.00030206487,0.0026593148],"category_scores_gemma":[0.00023439604,0.00010896724,0.0001721377,0.00020975646,0.0002352024,0.00019085628,0.00020541897,0.00041380516,0.0003231822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009338253,0.00010170007,0.00015560265,0.00009052304,0.000012265808,0.0003266607,0.000055602235,0.00060086045,0.99125504,0.0006769406,0.00021545947,0.0055753887],"study_design_scores_gemma":[0.00012106954,0.0037470115,0.0011110364,0.0000070469714,0.000017487859,0.000326503,0.000030116222,0.00045474552,0.9903194,0.00008471634,0.0037723556,0.0000086208665],"about_ca_topic_score_codex":0.0012579862,"about_ca_topic_score_gemma":0.0013666331,"teacher_disagreement_score":0.0026593148,"about_ca_system_score_codex":0.00026905324,"about_ca_system_score_gemma":0.00033217014,"threshold_uncertainty_score":0.008896291},"labels":[],"label_agreement":null},{"id":"W2079065151","doi":"10.1016/j.bmcl.2013.12.033","title":"Design and synthesis of potential dual NK1/NK3 receptor antagonists","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Institut de Recherches Servier; Natural Sciences and Engineering Research Council of Canada; Université de Montréal; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Tachykinin receptor; Peptidomimetic; Receptor; Pharmacology; Stereochemistry; Combinatorial chemistry; Biochemistry; Substance P; Medicine; Peptide","score_opus":0.0060252784238391715,"score_gpt":0.19461269920724664,"score_spread":0.18858742078340746,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2079065151","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.832578,0.020720175,0.10642031,0.0016765055,0.00057852163,0.0011131362,0.0023505087,0.0007487411,0.033814095],"genre_scores_gemma":[0.92024666,0.014761511,0.046160214,0.0005588744,0.00007130686,0.0004919504,0.0013551597,0.000082707775,0.016271565],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999162,0.000011855077,0.0000086227365,0.000014209184,0.000015293155,0.000033944496],"domain_scores_gemma":[0.9999629,0.0000038916573,0.000008728191,0.00000393886,0.000006705021,0.000013908782],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021190174,0.00040424053,0.00040982114,0.00022138831,0.0002610957,0.0004005977,0.0005213055,0.0003240881,0.003121802],"category_scores_gemma":[0.00015507046,0.00025877825,0.00026612318,0.00020679401,0.0001895939,0.00037625516,0.00044695742,0.0006935764,0.0012859801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007382648,0.00024034295,0.0002594574,0.0005812038,0.000061448765,0.00068032544,0.00016289191,0.003725166,0.9232828,0.011037092,0.0027494936,0.056481514],"study_design_scores_gemma":[0.0006986263,0.0028702025,0.0008350516,0.000081906575,0.00013214242,0.0014028396,0.00008860614,0.0077439765,0.8667825,0.0027057102,0.116580576,0.00007790784],"about_ca_topic_score_codex":0.00040132357,"about_ca_topic_score_gemma":0.0011120479,"teacher_disagreement_score":0.003121802,"about_ca_system_score_codex":0.00043692708,"about_ca_system_score_gemma":0.0004432098,"threshold_uncertainty_score":0.010443449},"labels":[],"label_agreement":null},{"id":"W2079171931","doi":"10.1016/s0960-894x(00)00079-2","title":"Structural comparison between type I and type II antagonists: possible implications in the drug design of AT1 antagonists","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"State Scholarships Foundation; Bristol-Myers Squibb","keywords":"Chemistry; Stereochemistry; Antagonist; Angiotensin II receptor type 1; Agonist; Angiotensin II; Receptor; Biochemistry","score_opus":0.03503183592821673,"score_gpt":0.30695921186277725,"score_spread":0.2719273759345605,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2079171931","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94088215,0.0105392635,0.028906513,0.0016744386,0.00033289153,0.00007359146,0.0010800292,0.000288913,0.0162222],"genre_scores_gemma":[0.98429227,0.003227088,0.0090371715,0.00081440876,0.00010354411,0.000034821765,0.0009935155,0.000047107555,0.0014501822],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999889,0.0000406268,0.000008988115,0.00002071775,0.000023573433,0.000017060886],"domain_scores_gemma":[0.9997743,0.0000790621,0.00005546747,0.000020312185,0.000031775828,0.000039059745],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021921119,0.00031361106,0.0006685456,0.00019716189,0.0003185433,0.0006465005,0.0005301072,0.00045518638,0.005101038],"category_scores_gemma":[0.00054356264,0.00015577738,0.00042162032,0.00023313051,0.00016417685,0.000509281,0.00018386364,0.00066391524,0.0007989161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0049001207,0.00035334882,0.009886657,0.0007823164,0.00035831713,0.001131974,0.00023363618,0.02536277,0.85536367,0.028092127,0.004462751,0.069072224],"study_design_scores_gemma":[0.0020500165,0.009635983,0.068988845,0.0003189076,0.0022913741,0.0072308136,0.0013304036,0.22089665,0.54182595,0.067159705,0.07797704,0.0002943142],"about_ca_topic_score_codex":0.00040839295,"about_ca_topic_score_gemma":0.000915377,"teacher_disagreement_score":0.005101038,"about_ca_system_score_codex":0.00023578305,"about_ca_system_score_gemma":0.00033932782,"threshold_uncertainty_score":0.017064631},"labels":[],"label_agreement":null},{"id":"W2079338190","doi":"10.1016/j.bmcl.2010.02.003","title":"Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: Improved drug-like properties through C-2 SAR in three sub-series","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; NS5B; Stereochemistry; ADME; Allosteric regulation; Benzimidazole; Polymerase; Biochemistry; Enzyme; In vitro; Genotype; Hepacivirus","score_opus":0.016169060146238794,"score_gpt":0.24730725134448628,"score_spread":0.2311381911982475,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2079338190","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9786059,0.0051449654,0.0027094085,0.00024400144,0.000121891,0.00014560074,0.00058126275,0.0002825081,0.012164349],"genre_scores_gemma":[0.98928624,0.0031727576,0.0018172023,0.00028005362,0.00003183564,0.000046169665,0.0007675748,0.000028685283,0.004569413],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999211,0.000007583835,0.0000059072377,0.000010928443,0.000015319227,0.00003900845],"domain_scores_gemma":[0.99995923,0.000004970561,0.00000790812,0.0000060142474,0.00000603766,0.000015867767],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219639,0.00041521087,0.00045468766,0.00019866058,0.00024061765,0.0002793012,0.00047114654,0.00019223208,0.0028191616],"category_scores_gemma":[0.00014624278,0.0001293704,0.0002681835,0.00017926285,0.00018869613,0.00027105564,0.00025476387,0.0006099313,0.0005733425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003512181,0.00071881287,0.0012947636,0.00039692924,0.0000841846,0.00060008303,0.00015351617,0.0047259643,0.9151053,0.001704771,0.0029514076,0.068752065],"study_design_scores_gemma":[0.0010183793,0.012263557,0.008655284,0.00006626452,0.00032873233,0.0020013428,0.000108184024,0.009967207,0.9407246,0.00053008617,0.02423691,0.00009947882],"about_ca_topic_score_codex":0.001369904,"about_ca_topic_score_gemma":0.0035836415,"teacher_disagreement_score":0.0028191616,"about_ca_system_score_codex":0.00034975837,"about_ca_system_score_gemma":0.000317888,"threshold_uncertainty_score":0.0094310045},"labels":[],"label_agreement":null},{"id":"W2079392960","doi":"10.1016/j.bmcl.2008.12.075","title":"N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Trifluoromethyl; Pyrazole; Thiazole; Benzofuran; Stereochemistry; Pyridine; Chemical synthesis; Carboxamide; Isoindoline; Enzyme inhibitor; Lipophilicity; Enzyme; Biochemistry; Medicinal chemistry; In vitro; Organic chemistry","score_opus":0.010821960931158017,"score_gpt":0.23894239122866717,"score_spread":0.22812043029750917,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2079392960","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9654339,0.011801991,0.0069049853,0.00028306834,0.00022540212,0.0001245575,0.00033592907,0.00038036157,0.014509742],"genre_scores_gemma":[0.9915379,0.003315392,0.002019727,0.00007944725,0.0000406374,0.00006334111,0.00025363397,0.00001770518,0.002672211],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998387,0.000030647636,0.000007980531,0.000022646649,0.00003124871,0.000068775196],"domain_scores_gemma":[0.9999417,0.000011814679,0.000017466893,0.0000073433207,0.000007582545,0.000013988834],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028826683,0.00029504768,0.00035185143,0.0002482928,0.00019382745,0.00016283325,0.000643723,0.000317192,0.0015351534],"category_scores_gemma":[0.00018722762,0.00013925525,0.00020442287,0.00019784927,0.00018041927,0.00022159315,0.00019165466,0.00044505842,0.00043853023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013083705,0.00025176967,0.00044539807,0.00023686675,0.000034993333,0.0004408501,0.00010331435,0.0010797796,0.9614193,0.001846562,0.0013587573,0.03147409],"study_design_scores_gemma":[0.0006609238,0.004021481,0.005101255,0.000027952903,0.00008427557,0.001380722,0.000045377623,0.0029579478,0.9652242,0.00017261019,0.02028423,0.00003897567],"about_ca_topic_score_codex":0.0010525716,"about_ca_topic_score_gemma":0.0022867848,"teacher_disagreement_score":0.0015351534,"about_ca_system_score_codex":0.00037187152,"about_ca_system_score_gemma":0.00023029497,"threshold_uncertainty_score":0.005135596},"labels":[],"label_agreement":null},{"id":"W2080049264","doi":"10.1016/j.bmcl.2008.10.010","title":"Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5′-hydroxybutitaxel","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of New Brunswick","funders":"National Cancer Institute","keywords":"Chemistry; Paclitaxel; Tubulin; Stereochemistry; Cancer cell lines; Cell growth; Chemical synthesis; In vitro; Kinetic resolution; Cell culture; Biological activity; Cancer cell; Cancer; Microtubule; Biochemistry; Catalysis; Enantioselective synthesis; Cell biology","score_opus":0.0195359295680108,"score_gpt":0.27404566351961523,"score_spread":0.2545097339516044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080049264","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99092454,0.00385468,0.00072593946,0.00010856223,0.000058419337,0.000024868194,0.0006778032,0.00005655202,0.0035686088],"genre_scores_gemma":[0.9926928,0.0018865899,0.00049096416,0.00003494203,0.000016114704,0.000020212445,0.0015682962,0.000017710663,0.0032724165],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999145,0.000012342708,0.000008507015,0.000012194549,0.00001708643,0.000035404784],"domain_scores_gemma":[0.99994075,0.0000115539315,0.000010013515,0.000009688092,0.0000069513294,0.00002103655],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012852311,0.0002799581,0.00019988517,0.00021996576,0.00017010533,0.00018212055,0.00031194952,0.00019203735,0.0012632675],"category_scores_gemma":[0.00009264331,0.00021674029,0.00019302111,0.00017259724,0.00014594397,0.00017187299,0.00008226377,0.00040197698,0.0003921898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00050675956,0.00006017982,0.00015061485,0.0000361667,0.0000062070267,0.000063204345,0.000020792157,0.00014503053,0.9971294,0.00013054545,0.000090303314,0.0016608102],"study_design_scores_gemma":[0.00004065923,0.0006383371,0.0017596553,0.0000043884042,0.000016098784,0.00006519044,0.00001536567,0.0003167008,0.9953011,0.00001683708,0.0018224246,0.0000031286575],"about_ca_topic_score_codex":0.0023903705,"about_ca_topic_score_gemma":0.0029599413,"teacher_disagreement_score":0.0023903705,"about_ca_system_score_codex":0.00026596288,"about_ca_system_score_gemma":0.00034857832,"threshold_uncertainty_score":0.004752934},"labels":[],"label_agreement":null},{"id":"W2080051749","doi":"10.1016/j.bmcl.2007.07.075","title":"(1 ,2 )-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Benzonitrile; Trifluoromethyl; Potency; Antagonist; Androgen receptor; Stereochemistry; Chemical synthesis; Hamster; Pharmacokinetics; Pharmacology; Receptor; Endocrinology; Internal medicine; Biochemistry; In vitro; Alkyl; Medicinal chemistry; Organic chemistry","score_opus":0.0065122006009318755,"score_gpt":0.2332716295702423,"score_spread":0.22675942896931042,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080051749","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93420905,0.017946808,0.01435658,0.0010072871,0.00048184596,0.00023661906,0.0007800566,0.0006960685,0.030285688],"genre_scores_gemma":[0.9884084,0.0030621707,0.0023155394,0.000147424,0.000083564126,0.00006141276,0.00031193031,0.000023220595,0.0055864695],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998361,0.0000309361,0.0000064525293,0.000023422539,0.000028771143,0.000074348354],"domain_scores_gemma":[0.9999379,0.000010878589,0.000019563897,0.0000063793855,0.000009090875,0.000016235708],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001858031,0.00033225058,0.0003064639,0.0002242675,0.00025796337,0.00011391103,0.0003741058,0.00033204758,0.002001495],"category_scores_gemma":[0.00015362039,0.0001166564,0.0001562497,0.00012672169,0.00018871234,0.00019718596,0.00016308857,0.00030039917,0.00061378477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009122371,0.00005232134,0.00013063064,0.0001257449,0.000007099274,0.00025729602,0.000024438097,0.0001410155,0.98952895,0.00041879786,0.0003815854,0.008019996],"study_design_scores_gemma":[0.00022843046,0.002354033,0.0043734307,0.000015271346,0.000021910186,0.0013441991,0.000042097072,0.0007030888,0.98010916,0.00008146252,0.010707333,0.000019554342],"about_ca_topic_score_codex":0.0020340097,"about_ca_topic_score_gemma":0.003076253,"teacher_disagreement_score":0.0020340097,"about_ca_system_score_codex":0.000314369,"about_ca_system_score_gemma":0.00042479226,"threshold_uncertainty_score":0.006695688},"labels":[],"label_agreement":null},{"id":"W2080334313","doi":"10.1016/s0960-894x(02)00631-5","title":"Neuroprotection against ischemic brain injury conferred by a novel nitrate ester","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"","keywords":"Neuroprotection; Ischemia; Chemistry; Nitrate; Ischemic injury; Middle cerebral artery; Pharmacology; Selectivity; Cerebral ischaemia; Internal medicine; Biochemistry; Medicine; Organic chemistry","score_opus":0.015646847438380785,"score_gpt":0.2251828442680644,"score_spread":0.2095359968296836,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080334313","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9899719,0.0018269871,0.0038648688,0.00025616642,0.00010565918,0.00005258041,0.00020166032,0.00008536401,0.0036348847],"genre_scores_gemma":[0.98882395,0.001948552,0.004003536,0.00020932661,0.00004369272,0.00004395795,0.00035417013,0.000027308797,0.0045454972],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999565,0.0000071762815,0.0000047275757,0.00000987749,0.0000060683014,0.000015611799],"domain_scores_gemma":[0.9999521,0.000009002966,0.000010436076,0.000006489245,0.000006874846,0.000014996896],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002428181,0.00038427397,0.0003554098,0.00012891857,0.0002291787,0.00017597078,0.0004621582,0.00047887664,0.0015676722],"category_scores_gemma":[0.00012705951,0.00012789288,0.00020226112,0.00007854612,0.0001835471,0.0003889687,0.00020845154,0.00036485223,0.00033568757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001506623,0.00008647787,0.00013467307,0.000085196596,0.00001448695,0.00035769242,0.000035789206,0.000118284894,0.9915268,0.00056248077,0.00015662731,0.0054149614],"study_design_scores_gemma":[0.00034979585,0.0029408708,0.0013775161,0.000018852648,0.00006141096,0.00083850144,0.000022077626,0.0006073606,0.988634,0.00023660247,0.004895215,0.000017758628],"about_ca_topic_score_codex":0.0005474206,"about_ca_topic_score_gemma":0.0009412132,"teacher_disagreement_score":0.0015676722,"about_ca_system_score_codex":0.00017950778,"about_ca_system_score_gemma":0.00025677303,"threshold_uncertainty_score":0.0052443743},"labels":[],"label_agreement":null},{"id":"W2080349460","doi":"10.1016/j.bmcl.2014.12.046","title":"Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"Bristol-Myers Squibb","keywords":"Linker; Chemistry; NS5A; Biphenyl; Drug discovery; Combinatorial chemistry; Stereochemistry; Potency; Biochemistry; Genotype; Hepacivirus; In vitro; Organic chemistry","score_opus":0.011348756774534766,"score_gpt":0.23102002600933397,"score_spread":0.2196712692347992,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080349460","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9523664,0.016533554,0.015131222,0.00052607927,0.00010216862,0.0004898793,0.0013560144,0.00024423978,0.013250483],"genre_scores_gemma":[0.9779588,0.009357854,0.0059044156,0.00017449218,0.00001720667,0.0001231559,0.0008214169,0.000014445869,0.005628141],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999145,0.000011889081,0.0000047872045,0.000011281901,0.000022426748,0.000035175657],"domain_scores_gemma":[0.9999696,0.0000044550375,0.000009634267,0.00000285238,0.0000056278354,0.000007772777],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019525032,0.00042758152,0.00026839427,0.00021237928,0.00013689256,0.00021728966,0.00036623116,0.00025794713,0.0018440499],"category_scores_gemma":[0.0001685211,0.00015888222,0.00022974075,0.00017928985,0.00014513324,0.00019469076,0.00020558045,0.00031463586,0.00040760462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006754603,0.00023582998,0.0004664707,0.0002973694,0.00004239367,0.0002632392,0.00008619021,0.002086616,0.95733994,0.0016892395,0.0013529048,0.035464343],"study_design_scores_gemma":[0.00049254275,0.0028460866,0.004139941,0.000048549307,0.000097047276,0.0006030865,0.000033737408,0.0044836435,0.9628271,0.00020770283,0.02418298,0.000037542304],"about_ca_topic_score_codex":0.0019842337,"about_ca_topic_score_gemma":0.0063444925,"teacher_disagreement_score":0.0019842337,"about_ca_system_score_codex":0.000678675,"about_ca_system_score_gemma":0.00038472645,"threshold_uncertainty_score":0.0061689615},"labels":[],"label_agreement":null},{"id":"W2080677728","doi":"10.1016/j.bmcl.2007.11.013","title":"Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Liver X receptor; Chemistry; Selectivity; Quinoline; Ligand (biochemistry); Carboxylic acid; Agonist; Receptor; Stereochemistry; Biochemistry; Nuclear receptor; Organic chemistry; Gene; Transcription factor","score_opus":0.01779704800949333,"score_gpt":0.24936721002933146,"score_spread":0.23157016201983813,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080677728","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9269353,0.041054543,0.01208813,0.0008255673,0.0003244059,0.00018435379,0.00034923796,0.00037429944,0.017864067],"genre_scores_gemma":[0.9812943,0.009527233,0.0031049738,0.00032406693,0.00007196671,0.00004027046,0.00016475041,0.000022600758,0.0054499293],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999174,0.000030613533,0.0000050405424,0.000010774262,0.000015236123,0.000020915753],"domain_scores_gemma":[0.9999504,0.0000099397885,0.000011580453,0.000005982817,0.000011205283,0.000010902063],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028352227,0.000248303,0.0003333137,0.00016481381,0.00018050653,0.0002475612,0.00040837916,0.0002836434,0.002468515],"category_scores_gemma":[0.00015842852,0.00014138615,0.00014209314,0.00015215093,0.0001934615,0.00029736222,0.00022966649,0.00035490887,0.00047322578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019947423,0.000114564646,0.00031242802,0.0003513959,0.000022691276,0.0005183987,0.00013206522,0.000998981,0.95799536,0.0036418834,0.0011902442,0.032727234],"study_design_scores_gemma":[0.0007186379,0.0065739206,0.0023724406,0.000056663983,0.0001101872,0.001937738,0.0001050179,0.0028661396,0.92566603,0.000830615,0.05870096,0.00006167722],"about_ca_topic_score_codex":0.00031818758,"about_ca_topic_score_gemma":0.0005880996,"teacher_disagreement_score":0.002468515,"about_ca_system_score_codex":0.00012705175,"about_ca_system_score_gemma":0.00009490593,"threshold_uncertainty_score":0.008258045},"labels":[],"label_agreement":null},{"id":"W2080719869","doi":"10.1016/s0960-894x(02)01022-3","title":"Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Tetrapeptide; Chemistry; Cyclic peptide; Receptor; Stereochemistry; Integrin; Amino acid; Peptide; Oligopeptide; Solid-phase synthesis; Alpha (finance); BETA (programming language); Chemical synthesis; Cleavage (geology); Biochemistry; In vitro","score_opus":0.014374505487995529,"score_gpt":0.3210019394073219,"score_spread":0.3066274339193264,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080719869","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96841383,0.0039551235,0.016699433,0.00015891428,0.000116450705,0.00016395157,0.00054401543,0.00015477005,0.009793404],"genre_scores_gemma":[0.9827927,0.001461394,0.012359109,0.00003992382,0.000015551726,0.0000611845,0.00032014088,0.00002435883,0.0029256607],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999269,0.000010759055,0.000005951089,0.000009308221,0.00002289749,0.000024203906],"domain_scores_gemma":[0.9999541,0.000012243999,0.000011288395,0.0000049092087,0.0000063740704,0.000011145706],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009598162,0.00024010749,0.00023792005,0.00014155233,0.0001487349,0.00022817576,0.00024157182,0.00018817312,0.0014221653],"category_scores_gemma":[0.00011082582,0.00013829561,0.00016088311,0.00021067384,0.00012468011,0.00016528972,0.00014074385,0.0003177038,0.00040997544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001804647,0.00007315546,0.000056391615,0.000101042184,0.00000771818,0.0001497761,0.000028499904,0.0017923116,0.98774546,0.0010438615,0.00018723386,0.00863403],"study_design_scores_gemma":[0.000044365064,0.0002960438,0.00016625458,0.000005599908,0.000007830779,0.00007251137,0.000008044159,0.0017670891,0.9938372,0.00014703935,0.003641882,0.0000062222953],"about_ca_topic_score_codex":0.0003713332,"about_ca_topic_score_gemma":0.00088142435,"teacher_disagreement_score":0.0014221653,"about_ca_system_score_codex":0.00025985474,"about_ca_system_score_gemma":0.00030327452,"threshold_uncertainty_score":0.0047576427},"labels":[],"label_agreement":null},{"id":"W2081016768","doi":"10.1016/j.bmcl.2008.12.089","title":"Syntheses and potential anti-prostate cancer activities of ionone-based chalcones","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"LNCaP; Chemistry; Chalcone; Transactivation; Prostate cancer; Androgen receptor; Ionone; Antagonist; In vitro; Pharmacology; Prostate; Androgen Receptor Antagonists; Cancer research; Stereochemistry; Receptor; Biochemistry; Cancer; Internal medicine; Biology; Transcription factor","score_opus":0.026772861939219635,"score_gpt":0.2387827053106248,"score_spread":0.21200984337140516,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081016768","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9278558,0.015377726,0.017763285,0.0006413332,0.00036561652,0.0006468059,0.0019982376,0.0004376395,0.034913626],"genre_scores_gemma":[0.9798117,0.0069406563,0.004337029,0.00016310123,0.00006803533,0.00010663562,0.0009253784,0.000035666988,0.00761181],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988925,0.000022717406,0.000016014144,0.000013561689,0.00002255812,0.000035944548],"domain_scores_gemma":[0.9998996,0.000016417705,0.0000187473,0.000012900519,0.000019807423,0.00003251028],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025646598,0.00055812823,0.00033421232,0.0008984721,0.0004150035,0.00031847347,0.0005883872,0.00026790623,0.004756913],"category_scores_gemma":[0.0002449191,0.00013511808,0.00036760568,0.00066419283,0.00033682593,0.0003674897,0.00034209524,0.00047043926,0.0010070561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016432925,0.0005848085,0.0005792751,0.0014400805,0.00006558386,0.0022706238,0.00047047276,0.004705493,0.9191864,0.0051921792,0.0018112067,0.062050607],"study_design_scores_gemma":[0.00020421365,0.0026453333,0.0015989272,0.00006981575,0.00007752902,0.000643661,0.0001224724,0.0008885504,0.972316,0.00059837406,0.020780966,0.000054137654],"about_ca_topic_score_codex":0.00080834544,"about_ca_topic_score_gemma":0.0014315622,"teacher_disagreement_score":0.004756913,"about_ca_system_score_codex":0.0004894622,"about_ca_system_score_gemma":0.0005651871,"threshold_uncertainty_score":0.015913486},"labels":[],"label_agreement":null},{"id":"W2081658993","doi":"10.1016/j.bmcl.2010.09.087","title":"Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Cognitive impairment; Cognition; Pharmacology; Neuroscience; Psychology","score_opus":0.00703732679574486,"score_gpt":0.2385464185508802,"score_spread":0.23150909175513534,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081658993","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95663565,0.019660778,0.006767659,0.0028117388,0.00040793463,0.0004890857,0.0013671248,0.0004718232,0.011388178],"genre_scores_gemma":[0.97964627,0.0090806605,0.0044314475,0.0010384101,0.00013167024,0.000119305885,0.0011162746,0.000023290235,0.0044126916],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999194,0.000011636332,0.000008243169,0.00001279689,0.000014868355,0.00003306522],"domain_scores_gemma":[0.99995244,0.0000061232363,0.000008669366,0.0000038112828,0.000008631755,0.000020401892],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026984166,0.0006160637,0.00086477585,0.00039989394,0.00021117482,0.00051162764,0.0006462674,0.0006420378,0.001303803],"category_scores_gemma":[0.00018712001,0.00031786558,0.00066851755,0.00018033468,0.00024814042,0.00030168385,0.00024458353,0.0010860256,0.000553121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.004745891,0.0012837194,0.0016900781,0.0006168262,0.00026215852,0.0030192262,0.00009696239,0.0010152389,0.8513583,0.0026310552,0.004569989,0.1287106],"study_design_scores_gemma":[0.019292261,0.03807296,0.038040023,0.0002224418,0.0017940447,0.016740754,0.00015152441,0.010532303,0.79904824,0.0014355335,0.074463606,0.00020631032],"about_ca_topic_score_codex":0.0011528542,"about_ca_topic_score_gemma":0.003331768,"teacher_disagreement_score":0.001303803,"about_ca_system_score_codex":0.00048786873,"about_ca_system_score_gemma":0.00056321913,"threshold_uncertainty_score":0.0043616295},"labels":[],"label_agreement":null},{"id":"W2081873746","doi":"10.1016/j.bmcl.2009.11.050","title":"Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Morpholine; Pyran; Stereochemistry; Aryl; PI3K/AKT/mTOR pathway; Potency; Selectivity; Combinatorial chemistry; Biochemistry; In vitro; Medicinal chemistry; Signal transduction; Organic chemistry","score_opus":0.0053945665785296885,"score_gpt":0.22277441761772265,"score_spread":0.21737985103919297,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081873746","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98108494,0.00408837,0.0075191506,0.00039022267,0.00014382567,0.00016191651,0.00045539672,0.00023164025,0.005924465],"genre_scores_gemma":[0.9918426,0.0013862359,0.0045590196,0.000085013664,0.000020038031,0.00004005763,0.00023956748,0.000015799847,0.0018116498],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999031,0.00002422695,0.000008474933,0.00001666659,0.000022403083,0.000025114803],"domain_scores_gemma":[0.99994004,0.00000970312,0.00001535884,0.000007987371,0.0000095887945,0.000017357765],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029496892,0.00018788375,0.00024917646,0.00018668141,0.00013217135,0.00021827515,0.0004968151,0.00035191164,0.0009332538],"category_scores_gemma":[0.00020460054,0.00015952678,0.00017828592,0.0001334251,0.00021488837,0.0002720057,0.00019531512,0.00031961984,0.00026396514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038670126,0.00017943892,0.0004049747,0.00012155522,0.000018931221,0.00048442715,0.000103404986,0.0014839234,0.9716475,0.0029172918,0.000568536,0.02168332],"study_design_scores_gemma":[0.0002487601,0.0023061559,0.0022142937,0.000011382613,0.00004205978,0.0011412222,0.000035558813,0.003813902,0.9738096,0.00027446175,0.016072102,0.00003056936],"about_ca_topic_score_codex":0.0007204775,"about_ca_topic_score_gemma":0.0014826038,"teacher_disagreement_score":0.0009332538,"about_ca_system_score_codex":0.00035509892,"about_ca_system_score_gemma":0.0003210473,"threshold_uncertainty_score":0.0031220913},"labels":[],"label_agreement":null},{"id":"W2081894758","doi":"10.1016/s0960-894x(00)00568-0","title":"Substituted 1,6-naphthyridines as human cytomegalovirus inhibitors: conformational requirements","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Chemistry; Human cytomegalovirus; Intramolecular force; Hydrogen bond; Stereochemistry; Cytomegalovirus; Combinatorial chemistry; Chemical synthesis; Enzyme inhibitor; Structure–activity relationship; In vitro; Biochemistry; Molecule; Virology; Herpesviridae; Virus; Organic chemistry; Viral disease","score_opus":0.008891678838311046,"score_gpt":0.24580990242773085,"score_spread":0.2369182235894198,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081894758","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9812386,0.0078000613,0.00474208,0.00020212795,0.00005055585,0.000060171024,0.00016095523,0.00014136787,0.0056039905],"genre_scores_gemma":[0.98917645,0.0048677563,0.0031120533,0.00010853082,0.000019323767,0.000059713333,0.00023912865,0.00004427913,0.0023727329],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999879,0.000040563293,0.000010334947,0.000016253449,0.00002720892,0.000026585469],"domain_scores_gemma":[0.99991274,0.000039228602,0.000018155033,0.000010789934,0.000009589429,0.000009576351],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029901793,0.00030616924,0.00031684927,0.00009741852,0.00014811996,0.00024314522,0.0006293488,0.0002960189,0.0015938788],"category_scores_gemma":[0.0002793888,0.00019327509,0.00011298156,0.000109307024,0.0002099994,0.000518222,0.00022535703,0.00051405106,0.00046414734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000678313,0.0000693622,0.00010247785,0.00015460463,0.000010898047,0.00018943638,0.00009290146,0.002066027,0.9839039,0.002185531,0.00025561076,0.01029098],"study_design_scores_gemma":[0.00011737898,0.0010122615,0.0004943725,0.000017673017,0.000021277268,0.0004496158,0.000027667078,0.002896485,0.9872706,0.00040376605,0.0072672246,0.000021719161],"about_ca_topic_score_codex":0.0003472172,"about_ca_topic_score_gemma":0.0008160885,"teacher_disagreement_score":0.0015938788,"about_ca_system_score_codex":0.0003332019,"about_ca_system_score_gemma":0.00015295096,"threshold_uncertainty_score":0.0053321123},"labels":[],"label_agreement":null},{"id":"W2081973447","doi":"10.1016/j.bmcl.2011.10.013","title":"Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of spirocyclic piperidines","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"hERG; Chemistry; Renin inhibitor; Renin–angiotensin system; CYP3A4; Potency; Series (stratigraphy); Stereochemistry; Drug discovery; Pharmacology; Combinatorial chemistry; In vitro; Enzyme; Biochemistry; Internal medicine; Cytochrome P450","score_opus":0.07421226829586887,"score_gpt":0.24123828654313645,"score_spread":0.1670260182472676,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2081973447","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9194158,0.032515675,0.035981547,0.0007830318,0.0002573261,0.00048246255,0.00062181207,0.00040867395,0.009533664],"genre_scores_gemma":[0.9465518,0.01810906,0.028313013,0.0005537502,0.00008234589,0.00015210734,0.00054229476,0.00003369653,0.0056618205],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991643,0.000018417453,0.000007923801,0.000015304862,0.000018763358,0.000023203771],"domain_scores_gemma":[0.99994576,0.000008692679,0.000015696336,0.0000042794436,0.000007991911,0.000017550134],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037012927,0.00034588,0.00035702047,0.00016802899,0.00013697808,0.00019384407,0.00039711013,0.00017899947,0.0017043818],"category_scores_gemma":[0.00019239308,0.0001558218,0.00022759367,0.00014633987,0.00015573358,0.00031445656,0.00018715532,0.000531441,0.00033551786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012521064,0.0005866579,0.0008511805,0.00064960524,0.00005815895,0.0006396151,0.00018522896,0.0045353887,0.8880708,0.003933194,0.0010378915,0.09820012],"study_design_scores_gemma":[0.0023552878,0.02426958,0.008660692,0.00022349971,0.00032988936,0.003016944,0.00015040736,0.01711414,0.8714497,0.0012592025,0.07102778,0.000142819],"about_ca_topic_score_codex":0.0002862394,"about_ca_topic_score_gemma":0.0014400416,"teacher_disagreement_score":0.0017043818,"about_ca_system_score_codex":0.0002092102,"about_ca_system_score_gemma":0.00030875017,"threshold_uncertainty_score":0.0057017803},"labels":[],"label_agreement":null},{"id":"W2082448040","doi":"10.1016/j.bmcl.2006.01.084","title":"Ketopiperazine-based renin inhibitors: Optimization of the “C” ring","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Steric effects; Renin–angiotensin system; Stereochemistry; Enzyme inhibitor; Ring (chemistry); Enzyme; Renin inhibitor; Inhibitory postsynaptic potential; CYP3A4; Side chain; Reduction (mathematics); Biological activity; Pharmacology; In vitro; Biochemistry; Internal medicine; Polymer; Organic chemistry; Blood pressure","score_opus":0.004173212106342079,"score_gpt":0.18687605310137348,"score_spread":0.1827028409950314,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2082448040","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9339295,0.009623293,0.032472406,0.0009955682,0.0002466633,0.0004676782,0.0009399289,0.00069530896,0.020629713],"genre_scores_gemma":[0.9769835,0.005391477,0.013073133,0.00031174175,0.000063189866,0.00009032,0.00046595355,0.00005192773,0.003568655],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983394,0.00003863388,0.000015282772,0.000032590993,0.000036728547,0.00004289582],"domain_scores_gemma":[0.99990284,0.000018629535,0.00002864676,0.000012803782,0.0000126440455,0.000024518955],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046676665,0.00060295063,0.00043972867,0.00020914913,0.00020388271,0.00034026548,0.0007275025,0.00028769052,0.00213742],"category_scores_gemma":[0.0002859808,0.00020187403,0.0002208467,0.00023389708,0.00030259666,0.0005209101,0.0002763383,0.0008259475,0.00066108414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0062678135,0.0008865893,0.0006488972,0.00091264315,0.00010674565,0.0017163885,0.00016244543,0.019944143,0.8589887,0.009930801,0.0039962167,0.09643869],"study_design_scores_gemma":[0.0020041335,0.0060152286,0.0015262676,0.00006125242,0.00017309307,0.0015504514,0.000059592057,0.013627893,0.9433931,0.001383093,0.030078245,0.0001276464],"about_ca_topic_score_codex":0.00081931584,"about_ca_topic_score_gemma":0.0016888091,"teacher_disagreement_score":0.00213742,"about_ca_system_score_codex":0.00041255186,"about_ca_system_score_gemma":0.00047101852,"threshold_uncertainty_score":0.0071504116},"labels":[],"label_agreement":null},{"id":"W2082448169","doi":"10.1016/s0960-894x(00)00022-6","title":"Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Epidermoid carcinoma; Stereochemistry; Chemical synthesis; In vitro; Cell culture; Lactam; Combinatorial chemistry; Basal cell; Biochemistry; Cancer research; Internal medicine","score_opus":0.014532511356990891,"score_gpt":0.25104958867768623,"score_spread":0.23651707732069535,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2082448169","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9668191,0.002166178,0.02314877,0.00028107353,0.00011199542,0.0003090317,0.0009973336,0.0001444102,0.006021966],"genre_scores_gemma":[0.9674334,0.002605284,0.022882978,0.00020394938,0.000021217666,0.00016596628,0.0010614773,0.000043274747,0.0055824975],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992037,0.000014154185,0.0000051535303,0.0000109794355,0.00001621498,0.000033202483],"domain_scores_gemma":[0.99994993,0.0000062699833,0.000012608313,0.000005931779,0.000007962641,0.000017187449],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181268,0.0004534681,0.00019785794,0.00018301672,0.00014953739,0.00025120235,0.00037044467,0.0003592827,0.0010936477],"category_scores_gemma":[0.0001241582,0.00022815466,0.00028338877,0.00024118174,0.00015033859,0.00022265507,0.00019048796,0.00053203985,0.00035793096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025913992,0.00008700355,0.000079952326,0.00008079832,0.000017468064,0.00019719402,0.000048575366,0.001951348,0.9906476,0.001149494,0.00023084678,0.0052505676],"study_design_scores_gemma":[0.000062795836,0.000511929,0.0003571445,0.0000056177496,0.000019839687,0.0001016911,0.000016875501,0.0010577379,0.99199593,0.0001236472,0.005735179,0.000011629386],"about_ca_topic_score_codex":0.00043565343,"about_ca_topic_score_gemma":0.0009295882,"teacher_disagreement_score":0.0010936477,"about_ca_system_score_codex":0.00029116595,"about_ca_system_score_gemma":0.00024746775,"threshold_uncertainty_score":0.0036586523},"labels":[],"label_agreement":null},{"id":"W2083424248","doi":"10.1016/s0960-894x(00)00618-1","title":"Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; McGill University; Welch Foundation","keywords":"Peptidomimetic; Chemistry; Stereochemistry; Receptor; Depsipeptide; Biochemistry; Peptide","score_opus":0.026909833748509675,"score_gpt":0.2576389204700402,"score_spread":0.23072908672153056,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083424248","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97696054,0.008924365,0.00641766,0.00041255314,0.00023887037,0.00011277994,0.00022858781,0.00014733426,0.0065573566],"genre_scores_gemma":[0.9893758,0.003057608,0.0031093617,0.00022799245,0.000028054717,0.00003441623,0.00020095527,0.000020644982,0.0039451504],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998908,0.000025384039,0.0000073526526,0.000017462575,0.000026554466,0.000032332795],"domain_scores_gemma":[0.99994516,0.0000074132035,0.000011577433,0.000003197374,0.000006445404,0.0000261644],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016193799,0.00029903388,0.0003201014,0.00012119746,0.00014002154,0.00040478716,0.00032428835,0.00038333546,0.0017680344],"category_scores_gemma":[0.00018665187,0.00020262324,0.00012004875,0.00010195491,0.00013832832,0.00031203995,0.00025290332,0.0007093939,0.0006264962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010736432,0.000101008256,0.00010716393,0.000117781325,0.000017463375,0.00019258811,0.000056630462,0.0017385343,0.9834395,0.0007575255,0.000498278,0.011899912],"study_design_scores_gemma":[0.00085665635,0.0032789488,0.0008997172,0.000027689279,0.00007648639,0.0011013154,0.00013208305,0.0093700085,0.9665063,0.0005176402,0.017184297,0.000048893202],"about_ca_topic_score_codex":0.00024398237,"about_ca_topic_score_gemma":0.0003724546,"teacher_disagreement_score":0.0017680344,"about_ca_system_score_codex":0.0002734676,"about_ca_system_score_gemma":0.00012167049,"threshold_uncertainty_score":0.0059146285},"labels":[],"label_agreement":null},{"id":"W2083610909","doi":"10.1016/j.bmcl.2014.09.074","title":"Cytotoxic 1,5-diaryl-3-oxo-1,5-pentadienes: An assessment and comparison of membrane permeability using Caco-2 and MDCK monolayers","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Multicomponent Synthesis of Heterocycles","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Caco-2; Permeability (electromagnetism); Cytotoxic T cell; Membrane; Efflux; In vivo; Monolayer; Cytotoxicity; Membrane permeability; Conjugated system; In vitro; Biophysics; Chromatography; Stereochemistry; Biochemistry; Organic chemistry","score_opus":0.030311977846948664,"score_gpt":0.31778502148031396,"score_spread":0.2874730436333653,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083610909","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9937581,0.0021781772,0.001577703,0.000054203756,0.000026308993,0.000036860434,0.00027869167,0.000030342462,0.0020597791],"genre_scores_gemma":[0.99195766,0.00296599,0.0017732773,0.00004295022,0.000010942581,0.000039111546,0.00054097583,0.000010637842,0.0026583907],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997998,0.000052344574,0.000019190275,0.000023151973,0.00006129619,0.000044337623],"domain_scores_gemma":[0.9998696,0.0000566915,0.000017680093,0.000017222952,0.000018518298,0.000020383282],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002956528,0.00022508968,0.00028017195,0.00023122234,0.00013936352,0.0002704116,0.00023190763,0.00031603474,0.00094885],"category_scores_gemma":[0.00019317247,0.0001681152,0.00015285882,0.000287114,0.0001767384,0.00032459552,0.0001507421,0.0004020883,0.00020160552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002615077,0.00007033103,0.00009906477,0.000057505964,0.0000060081147,0.000034651028,0.000029462122,0.00022513614,0.99767905,0.00008387097,0.000035173514,0.0014182276],"study_design_scores_gemma":[0.000014853397,0.00089910126,0.001335943,0.0000038466073,0.000010334798,0.000094613635,0.000025726267,0.0005779838,0.99648714,0.00002327069,0.00052308897,0.0000041099734],"about_ca_topic_score_codex":0.00054879015,"about_ca_topic_score_gemma":0.0010469566,"teacher_disagreement_score":0.00094885,"about_ca_system_score_codex":0.00024106335,"about_ca_system_score_gemma":0.00017121495,"threshold_uncertainty_score":0.0031741858},"labels":[],"label_agreement":null},{"id":"W2083916084","doi":"10.1016/j.bmcl.2009.09.110","title":"1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Arginine; Moiety; Activator (genetics); Biochemistry; Stereochemistry; Enzyme; Enzyme inhibitor; Methyltransferase; Amino acid; Methylation; Gene","score_opus":0.0061630900687209104,"score_gpt":0.24531164511021455,"score_spread":0.23914855504149365,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083916084","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93531865,0.042312637,0.0062021855,0.00074697705,0.0006406931,0.00017791151,0.0006257757,0.00067418243,0.013301026],"genre_scores_gemma":[0.9843726,0.008419499,0.0026098848,0.00013918821,0.00006618938,0.00005249105,0.00036157874,0.00003490427,0.003943687],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985135,0.000046563335,0.00000862337,0.000024794352,0.000026255451,0.000042444542],"domain_scores_gemma":[0.9999156,0.000025308984,0.000018577966,0.0000075597695,0.000010327935,0.000022525632],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031161422,0.00043659692,0.00039630174,0.00032133912,0.00022175506,0.00031611003,0.00048619212,0.00044280099,0.001714884],"category_scores_gemma":[0.00021948054,0.00020355463,0.00021741731,0.00019361741,0.00018028481,0.00030220716,0.00025189813,0.0008016247,0.00040950364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0031977715,0.00027688558,0.00044235092,0.00032764184,0.0000519602,0.0003173655,0.00006688053,0.0017060613,0.9594771,0.0012629599,0.0016077267,0.03126525],"study_design_scores_gemma":[0.00031158995,0.0026462122,0.0009978556,0.000015196324,0.000050568735,0.0004742402,0.000025294461,0.0022208386,0.9795447,0.00016439693,0.013528844,0.000020385645],"about_ca_topic_score_codex":0.00060854235,"about_ca_topic_score_gemma":0.0017266177,"teacher_disagreement_score":0.001714884,"about_ca_system_score_codex":0.00044165464,"about_ca_system_score_gemma":0.00020084438,"threshold_uncertainty_score":0.0057368875},"labels":[],"label_agreement":null},{"id":"W2083974470","doi":"10.1016/s0960-894x(00)00400-5","title":"Synthesis and 5-Hydroxytryptamine (5-HT) activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Stereochemistry; Chemical synthesis; In vitro; Biochemistry","score_opus":0.013645253678096821,"score_gpt":0.22657921138747988,"score_spread":0.21293395770938306,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083974470","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98080355,0.008041609,0.004317459,0.00017569422,0.00010917116,0.0001625625,0.0007957261,0.00008529376,0.0055088173],"genre_scores_gemma":[0.9889586,0.0032697143,0.0030036506,0.000054999167,0.00005184784,0.00006700158,0.0009362007,0.000011381533,0.0036465777],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990416,0.00002306432,0.000013311851,0.000014141165,0.00002123385,0.0000240921],"domain_scores_gemma":[0.9999039,0.000021121246,0.000020621255,0.000012439013,0.000014949582,0.00002694353],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016902867,0.0002443609,0.00023883504,0.0002485633,0.0001787571,0.00016583373,0.00034875367,0.00024298715,0.0020669617],"category_scores_gemma":[0.00020450029,0.00019317247,0.00024673765,0.00013485896,0.00019055662,0.00028541533,0.00014789443,0.0003016666,0.0005262789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005510749,0.00009313448,0.00010157014,0.00015732557,0.000017856853,0.00025731054,0.00005082512,0.00070805126,0.9915005,0.0006083272,0.00013552952,0.0058185435],"study_design_scores_gemma":[0.00016778463,0.003325729,0.0017476933,0.000013118592,0.00003073489,0.00047803338,0.000026658505,0.000982049,0.98898494,0.00012844731,0.0040940335,0.000020695657],"about_ca_topic_score_codex":0.0003886344,"about_ca_topic_score_gemma":0.00059234345,"teacher_disagreement_score":0.0020669617,"about_ca_system_score_codex":0.00014595983,"about_ca_system_score_gemma":0.00019036267,"threshold_uncertainty_score":0.0069146752},"labels":[],"label_agreement":null},{"id":"W2084582736","doi":"10.1016/j.bmcl.2009.12.063","title":"Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":68,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Liminal BioSciences (Canada)","funders":"","keywords":"Antimicrobial; Chemistry; Bacteria; Triazine; Biological activity; Structure–activity relationship; Stereochemistry; Combinatorial chemistry; Ring (chemistry); Antibacterial agent; Antibiotics; Organic chemistry; In vitro; Biochemistry","score_opus":0.009375374647024658,"score_gpt":0.21189999396021542,"score_spread":0.20252461931319077,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084582736","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9811983,0.0054603647,0.0058539812,0.00019009145,0.00007871947,0.00008844381,0.0007134577,0.00016697621,0.006249754],"genre_scores_gemma":[0.98763347,0.0033746646,0.004331011,0.000077849014,0.000027379043,0.00005045097,0.00077149365,0.000020683132,0.0037128765],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998665,0.000026934682,0.000015000462,0.000016389034,0.000022847946,0.000052234467],"domain_scores_gemma":[0.999931,0.000008397867,0.000021455668,0.000008302308,0.000011115608,0.000019740286],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019826643,0.00030020563,0.00025347277,0.00028825446,0.00020977367,0.00014522168,0.00042714417,0.00021534205,0.0019248832],"category_scores_gemma":[0.00013285367,0.00014406795,0.00021180256,0.0002602383,0.00016885599,0.00019454249,0.00016168557,0.0003225567,0.0005129466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003365514,0.000086595006,0.00013706241,0.00012617753,0.000012007487,0.00020174806,0.000057195757,0.0006054065,0.99203134,0.0005476471,0.00018868076,0.0056695943],"study_design_scores_gemma":[0.000041910298,0.0011781204,0.001220447,0.000010541951,0.000020076703,0.00026660456,0.000018227944,0.0006207657,0.99276125,0.000043288783,0.0038067203,0.000012115211],"about_ca_topic_score_codex":0.00069175905,"about_ca_topic_score_gemma":0.0013093387,"teacher_disagreement_score":0.0019248832,"about_ca_system_score_codex":0.00029304603,"about_ca_system_score_gemma":0.000350467,"threshold_uncertainty_score":0.006439328},"labels":[],"label_agreement":null},{"id":"W2084719381","doi":"10.1016/j.bmcl.2008.06.085","title":"Efficient parallel synthesis of macrocyclic peptidomimetics","year":2008,"lang":"fr","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Peptidomimetic; Chemistry; Chemical synthesis; Solid-phase synthesis; Combinatorial chemistry; Stereochemistry; In vitro; Biochemistry; Peptide","score_opus":0.00874054554600597,"score_gpt":0.20956591886741927,"score_spread":0.2008253733214133,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084719381","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7989808,0.0051085604,0.14813922,0.0004639984,0.0005378514,0.000617201,0.0020695312,0.0021732252,0.041909624],"genre_scores_gemma":[0.8772597,0.0025827207,0.109264575,0.00014140499,0.00008612645,0.00031157333,0.0011083562,0.00021060223,0.009034837],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997812,0.000024435676,0.00001810441,0.00005106917,0.00007071965,0.000054471002],"domain_scores_gemma":[0.99989545,0.000019791176,0.000020766509,0.000020568385,0.000014614074,0.000028749428],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023231839,0.0005878104,0.00075948454,0.00031108526,0.00032168638,0.0006426635,0.0004665224,0.0002985596,0.0034396644],"category_scores_gemma":[0.00025569394,0.0003079309,0.0002575213,0.00043401984,0.0002193841,0.00066838023,0.0007331116,0.00067905156,0.0012303179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00086314045,0.00017590028,0.00023332224,0.00036910476,0.000051909716,0.0004265199,0.00009238,0.0085015865,0.8923738,0.008802428,0.0014861452,0.086623795],"study_design_scores_gemma":[0.00027479287,0.0010693497,0.0004494895,0.000016324351,0.000046847705,0.0003961393,0.000030603696,0.018279616,0.95276856,0.0033205526,0.023314318,0.000033495206],"about_ca_topic_score_codex":0.00031075563,"about_ca_topic_score_gemma":0.0008610717,"teacher_disagreement_score":0.0034396644,"about_ca_system_score_codex":0.0004907498,"about_ca_system_score_gemma":0.000630977,"threshold_uncertainty_score":0.011506796},"labels":[],"label_agreement":null},{"id":"W2084839458","doi":"10.1016/j.bmcl.2010.03.073","title":"Identification of a novel series of potent RON receptor tyrosine kinase inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Liver physiology and pathology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Trifluoromethyl; Tyrosine kinase; Stereochemistry; Structure–activity relationship; Enzyme; Enzyme inhibitor; Receptor tyrosine kinase; In vitro; Chemical synthesis; Kinase; Receptor; Biochemistry","score_opus":0.00984107970137353,"score_gpt":0.23057858647181198,"score_spread":0.22073750677043846,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2084839458","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9003907,0.035937104,0.026223166,0.0015157324,0.00052454916,0.0011198698,0.00249153,0.0009399722,0.030857358],"genre_scores_gemma":[0.93328464,0.021480717,0.015902493,0.0008710404,0.00011522492,0.00039888968,0.0037951733,0.000061014314,0.024090754],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989545,0.0000119712595,0.000007933615,0.000019180508,0.000030246314,0.000035145713],"domain_scores_gemma":[0.99994874,0.000004776633,0.000010347918,0.0000047530175,0.0000111564605,0.000020108131],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266516,0.00068136683,0.0005363495,0.0003967951,0.00023259856,0.00046437545,0.0004703393,0.00027918562,0.0026766644],"category_scores_gemma":[0.0001548896,0.00021978335,0.00028526734,0.00022088314,0.00019102416,0.00038869333,0.0003221575,0.00078757363,0.000743123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008954076,0.0010088457,0.0009926406,0.0004434197,0.00011169508,0.00063399633,0.00013133087,0.0028868504,0.8579378,0.003539955,0.006033249,0.12538476],"study_design_scores_gemma":[0.0012006578,0.009599757,0.006057807,0.000087674984,0.00027038678,0.0033588398,0.00007599732,0.006347486,0.83717537,0.0009219671,0.13482058,0.00008344491],"about_ca_topic_score_codex":0.0005317374,"about_ca_topic_score_gemma":0.002741509,"teacher_disagreement_score":0.0026766644,"about_ca_system_score_codex":0.0005814978,"about_ca_system_score_gemma":0.00043733837,"threshold_uncertainty_score":0.008954346},"labels":[],"label_agreement":null},{"id":"W2085097639","doi":"10.1016/j.bmcl.2014.11.071","title":"A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS)","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Prodrug; Chemistry; Bioavailability; Pharmacology; In vivo; Drug delivery; Bioconversion; Microsome; Oral administration; Drug; Solubility; In vitro; Chromatography; Biochemistry; Organic chemistry","score_opus":0.03742078827238764,"score_gpt":0.2904736658791129,"score_spread":0.25305287760672524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2085097639","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91146016,0.00399077,0.07393063,0.00054692867,0.0002119014,0.00045673118,0.0003440247,0.00049055135,0.0085684275],"genre_scores_gemma":[0.9659135,0.0015661897,0.02484476,0.0001600442,0.000017086917,0.000099397206,0.00016677377,0.000024096578,0.007208225],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994946,0.00000630162,0.000004469591,0.000014086067,0.000010767181,0.000015013929],"domain_scores_gemma":[0.9999784,0.000003345209,0.0000068198538,0.0000022261677,0.0000035243975,0.000005619475],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011672962,0.00034159565,0.00019540808,0.00014495288,0.00014502436,0.00021771895,0.00023308586,0.00030559095,0.0009954467],"category_scores_gemma":[0.00008983075,0.00016663133,0.0001882135,0.00006808584,0.0001266823,0.00025785813,0.00022433785,0.00042014505,0.0004051331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010428889,0.00005208637,0.000049834718,0.000080314676,0.0000061240985,0.00014589744,0.00002353058,0.00031662785,0.98442113,0.00065497507,0.00019861513,0.013946456],"study_design_scores_gemma":[0.000046389763,0.00067646307,0.00022768087,0.000005684804,0.0000130716135,0.00035799097,0.000010553661,0.0020803749,0.9917053,0.00006581442,0.004801359,0.000009272291],"about_ca_topic_score_codex":0.0004812142,"about_ca_topic_score_gemma":0.000765641,"teacher_disagreement_score":0.0009954467,"about_ca_system_score_codex":0.0002567434,"about_ca_system_score_gemma":0.00020368511,"threshold_uncertainty_score":0.0033301115},"labels":[],"label_agreement":null},{"id":"W2085268458","doi":"10.1016/j.bmcl.2014.01.024","title":"4′-Substituted pyrimidine nucleosides lacking 5′-hydroxyl function as potential anti-HCV agents","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Ribavirin; Hepatitis C virus; Pyrimidine; Chemistry; Replicon; Toxicity; EC50; Hepatitis C; Cirrhosis; Carboxamide; Liver cancer; In vitro; Pharmacology; Virology; Cancer; Virus; Stereochemistry; Biochemistry; Medicine; Internal medicine; Gene","score_opus":0.015358095245177424,"score_gpt":0.2677676959425239,"score_spread":0.25240960069734647,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2085268458","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96364534,0.021298923,0.003534021,0.00020788806,0.00018573718,0.000074853335,0.000271193,0.00012103358,0.010660916],"genre_scores_gemma":[0.9885111,0.005846836,0.002789009,0.00009379244,0.00003515124,0.00002803918,0.00021894397,0.000010881248,0.0024662812],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992967,0.000026891339,0.000006009008,0.000008419314,0.000011379388,0.000017761246],"domain_scores_gemma":[0.99994934,0.000010031771,0.000011629647,0.000006281794,0.000009122296,0.000013451288],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021356781,0.00028709212,0.000286596,0.00018303607,0.0001590171,0.00027610917,0.00031188558,0.00038094327,0.0015702926],"category_scores_gemma":[0.00014454006,0.00014619913,0.00019172794,0.0001322533,0.00016398488,0.00025886783,0.00018345017,0.00037207082,0.00039021755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016604934,0.00016685057,0.00053977006,0.00034995185,0.000026951671,0.0004991881,0.00006862891,0.001988302,0.95091826,0.0029088187,0.00044224667,0.040430594],"study_design_scores_gemma":[0.000257822,0.0050761076,0.0023874731,0.00005665964,0.00012022813,0.0010339153,0.00004528826,0.0029724143,0.95843637,0.00061902,0.028952641,0.000042033127],"about_ca_topic_score_codex":0.00036128718,"about_ca_topic_score_gemma":0.0005646459,"teacher_disagreement_score":0.0015702926,"about_ca_system_score_codex":0.00020641834,"about_ca_system_score_gemma":0.0001782334,"threshold_uncertainty_score":0.005253136},"labels":[],"label_agreement":null},{"id":"W2086145069","doi":"10.1016/j.bmcl.2006.08.025","title":"Comparison between two classes of selective EP3 antagonists and their biological activities","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Stereochemistry; Cinnamates; Organic chemistry","score_opus":0.015834019244833304,"score_gpt":0.27295267831369713,"score_spread":0.25711865906886383,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2086145069","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96403074,0.023731066,0.0044646626,0.00029594774,0.00017707949,0.00026657188,0.00092766335,0.00011834258,0.0059878235],"genre_scores_gemma":[0.9746211,0.012217365,0.0048194947,0.00056868687,0.00020289689,0.00032132157,0.0027059873,0.000036427817,0.0045068273],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998079,0.000040053856,0.000025089312,0.000024044612,0.000045965695,0.00005690271],"domain_scores_gemma":[0.9997851,0.00008026774,0.000025744053,0.000019820724,0.00004079192,0.000048252426],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032817354,0.0003333735,0.00070889137,0.0004342973,0.00021377031,0.00036945875,0.00034680645,0.0003750653,0.0043974775],"category_scores_gemma":[0.00054545805,0.00015065155,0.00042768035,0.00027928335,0.00017233987,0.00033898963,0.00017778242,0.00061262,0.0007527801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0063840384,0.0004496864,0.0006012559,0.00033283446,0.00015374055,0.00019993041,0.000054056138,0.00031455237,0.9394872,0.0006398646,0.0007809398,0.050601877],"study_design_scores_gemma":[0.002780203,0.028477365,0.011870155,0.00006868854,0.00090190035,0.002955052,0.000106245956,0.0017569975,0.918888,0.00046181917,0.03168336,0.000050147228],"about_ca_topic_score_codex":0.00032599043,"about_ca_topic_score_gemma":0.0004448962,"teacher_disagreement_score":0.0043974775,"about_ca_system_score_codex":0.0002434707,"about_ca_system_score_gemma":0.00028497184,"threshold_uncertainty_score":0.014711022},"labels":[],"label_agreement":null},{"id":"W2086426412","doi":"10.1016/j.bmcl.2005.01.014","title":"Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Free Radicals and Antioxidants","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Chemistry; Ergothioneine; Intracellular; Alkyl; Ab initio; Thiol; Stereochemistry; Computational chemistry; Biochemistry; Organic chemistry","score_opus":0.024322725351542077,"score_gpt":0.2250894437391547,"score_spread":0.20076671838761262,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2086426412","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97338265,0.0009948338,0.009167728,0.00028652715,0.00006859818,0.000027691809,0.00016641918,0.00013805294,0.015767511],"genre_scores_gemma":[0.99446493,0.0004259467,0.0029902547,0.000055511002,0.00002570765,0.00002532278,0.00013664256,0.000033584012,0.0018421644],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991965,0.000015084609,0.0000017274141,0.000009915623,0.000027159005,0.000026532674],"domain_scores_gemma":[0.99979764,0.00011620084,0.000015604066,0.00002459281,0.000032134405,0.000013775923],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023215056,0.0004165592,0.00055650115,0.00025855014,0.0005981127,0.00039305197,0.0007604644,0.0006669289,0.0050296327],"category_scores_gemma":[0.00041832967,0.00023573743,0.0003426892,0.00027329323,0.00049637153,0.00048339152,0.00039817815,0.0007837841,0.00042453138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018096452,0.00050340814,0.0037190677,0.002981901,0.00022211653,0.0011595346,0.0011882508,0.27769518,0.55078155,0.1305807,0.0037107489,0.025647895],"study_design_scores_gemma":[0.00028780315,0.00042953208,0.0037597192,0.000077819685,0.000088783076,0.00013407301,0.00054266857,0.85861343,0.11890041,0.014539235,0.002574484,0.000052006453],"about_ca_topic_score_codex":0.0017442552,"about_ca_topic_score_gemma":0.0020931181,"teacher_disagreement_score":0.0050296327,"about_ca_system_score_codex":0.0004414711,"about_ca_system_score_gemma":0.0002997849,"threshold_uncertainty_score":0.016825736},"labels":[],"label_agreement":null},{"id":"W2086480028","doi":"10.1016/j.bmcl.2006.10.061","title":"Synthesis and evaluation of peptidic maleimides as transglutaminase inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Blood properties and coagulation","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Tissue transglutaminase; Chemistry; Maleimide; Steric effects; Enzyme; Peptide; Substrate (aquarium); Enzyme inhibitor; In vitro; Biochemistry; Electrophile; Structure–activity relationship; Stereochemistry; Combinatorial chemistry; Organic chemistry; Catalysis","score_opus":0.01476558687234745,"score_gpt":0.23502371040007614,"score_spread":0.2202581235277287,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2086480028","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9602763,0.009282093,0.015148029,0.00024109679,0.00012143369,0.00036785228,0.00055871886,0.00016975513,0.013834718],"genre_scores_gemma":[0.98141724,0.005941502,0.0063507375,0.0000755088,0.000027774135,0.00008085414,0.0005530689,0.000027566433,0.005525781],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985373,0.000032518306,0.0000143948355,0.000021558159,0.00004471434,0.000032994314],"domain_scores_gemma":[0.99990904,0.000012374308,0.00002008495,0.0000101382075,0.000022314813,0.00002594584],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034012264,0.00046050843,0.00028763348,0.00024544014,0.00019715268,0.00024873117,0.00037795556,0.00031811083,0.001234428],"category_scores_gemma":[0.00023043223,0.00016358477,0.0002065589,0.00018662092,0.00017566918,0.00028305312,0.00018253588,0.00042650188,0.00034014822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047888648,0.00018227393,0.00015367268,0.0001637929,0.000019285326,0.00021901989,0.000053882228,0.0012744828,0.9800401,0.00079463783,0.00021485188,0.016405083],"study_design_scores_gemma":[0.000057897003,0.0011052841,0.000430411,0.000007079405,0.000020717753,0.00018247843,0.000010167682,0.000668974,0.9926473,0.000038294413,0.004823674,0.000007733851],"about_ca_topic_score_codex":0.00062004547,"about_ca_topic_score_gemma":0.0010337032,"teacher_disagreement_score":0.001234428,"about_ca_system_score_codex":0.00044331438,"about_ca_system_score_gemma":0.0003100333,"threshold_uncertainty_score":0.004129648},"labels":[],"label_agreement":null},{"id":"W2086555274","doi":"10.1016/j.bmcl.2010.03.116","title":"Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":54,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences Centre; Manitoba Health; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Aminoglycoside; Kanamycin; Peptide; Neomycin; Antibacterial activity; Amphiphile; Combinatorial chemistry; Conjugate; Triazole; Antibacterial agent; Stereochemistry; Biochemistry; Antibiotics; Bacteria; Organic chemistry","score_opus":0.025225476314122402,"score_gpt":0.286655162709797,"score_spread":0.2614296863956746,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2086555274","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99747366,0.0008128073,0.00086157833,0.000024325862,0.000012131126,0.000054418095,0.00004852316,0.000019835566,0.0006926311],"genre_scores_gemma":[0.99682873,0.0006895926,0.0014480738,0.00001559567,0.000007867591,0.000037364036,0.00008564139,0.000008456645,0.00087866554],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999694,0.000106780586,0.00002372507,0.00003474986,0.0000823982,0.00005842512],"domain_scores_gemma":[0.9998336,0.000046504596,0.00003700213,0.00001086147,0.000037179772,0.000034935558],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004134572,0.00032658863,0.00032864502,0.0002341336,0.00018860385,0.00026581532,0.00017602615,0.00036153075,0.0009818939],"category_scores_gemma":[0.00034583776,0.0001768655,0.00019343547,0.00025439108,0.00017995198,0.000247289,0.00017018238,0.00025824143,0.00018943379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030094836,0.000074312346,0.00006325751,0.000034925553,0.000004901355,0.000039912717,0.000018445644,0.00011954915,0.99806136,0.00003335863,0.000015254293,0.0012338351],"study_design_scores_gemma":[0.000032266296,0.001612375,0.0005868636,0.0000025680185,0.000018031627,0.000062374296,0.000009389973,0.0005808188,0.9966426,0.0000048756556,0.00044444544,0.0000033638412],"about_ca_topic_score_codex":0.0005326332,"about_ca_topic_score_gemma":0.00073872774,"teacher_disagreement_score":0.0009818939,"about_ca_system_score_codex":0.00022759518,"about_ca_system_score_gemma":0.00020771369,"threshold_uncertainty_score":0.0032847524},"labels":[],"label_agreement":null},{"id":"W2086610719","doi":"10.1016/j.bmcl.2011.08.037","title":"Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Bicyclic molecule; Chemistry; Pharmacology; Thiazole; Pharmacokinetics; Stereochemistry; Medicine","score_opus":0.019040029158063014,"score_gpt":0.2178598391050592,"score_spread":0.1988198099469962,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2086610719","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5614174,0.32384428,0.023749597,0.007514095,0.0015580669,0.00033076384,0.0015113584,0.0012441899,0.07883027],"genre_scores_gemma":[0.7925424,0.16010159,0.005643302,0.0024054975,0.0004311296,0.00013826638,0.0010280309,0.00008169473,0.037628133],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999349,0.000006807809,0.000003152987,0.0000096680615,0.000014807357,0.000030726707],"domain_scores_gemma":[0.99996746,0.000003760727,0.0000057528,0.0000036945637,0.0000071544864,0.000012237439],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021005765,0.0003791286,0.00042598814,0.00033307707,0.00014562854,0.00047237173,0.0002742535,0.000298604,0.0024675357],"category_scores_gemma":[0.00011657302,0.00016275766,0.00019451672,0.00027391905,0.00021290848,0.0002913431,0.00033851553,0.0008269169,0.0009537643],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.005118923,0.0005454051,0.001046383,0.00097510475,0.00016429489,0.00071860536,0.00017219206,0.0024594895,0.43442774,0.013885955,0.02172116,0.5187648],"study_design_scores_gemma":[0.0031627882,0.013984882,0.008352629,0.00037666236,0.0005520081,0.002678152,0.000166226,0.0045501883,0.492898,0.006274959,0.46685424,0.00014931044],"about_ca_topic_score_codex":0.0007374296,"about_ca_topic_score_gemma":0.0030972254,"teacher_disagreement_score":0.0024675357,"about_ca_system_score_codex":0.0004818311,"about_ca_system_score_gemma":0.00022223554,"threshold_uncertainty_score":0.008254766},"labels":[],"label_agreement":null},{"id":"W2086637419","doi":"10.1016/s0960-894x(00)00278-x","title":"Synthesis and PTP1B Inhibition of Novel 4-Aryl-1-Oxa-9-Thiacyclopenta[b]fluorenes","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Aryl; IC50; Potency; Stereochemistry; Substrate (aquarium); Phosphatase; Protein tyrosine phosphatase; Enzyme; Biochemistry; In vitro; Organic chemistry","score_opus":0.0073721731612712465,"score_gpt":0.21219364374112126,"score_spread":0.20482147057985,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2086637419","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95180136,0.011138089,0.013424827,0.0005269106,0.0002775427,0.00034959055,0.0014171196,0.00030065497,0.020763952],"genre_scores_gemma":[0.9852841,0.0042252406,0.003915425,0.00009517912,0.000038554368,0.0001111077,0.00048478504,0.00002055282,0.0058251065],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998795,0.00001752253,0.000010841064,0.000023197916,0.000016634898,0.00005224037],"domain_scores_gemma":[0.9999318,0.000013087086,0.000018714802,0.000008906404,0.00000801268,0.000019442896],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020152787,0.00040449286,0.00034105012,0.000286917,0.00029275924,0.0002220769,0.0005209824,0.0003970662,0.0030714248],"category_scores_gemma":[0.00017989655,0.00023585791,0.00027554802,0.00020122834,0.00018671737,0.00034228788,0.00026516657,0.0006302143,0.00052128563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00055897597,0.00022477203,0.0001335491,0.00034515746,0.000029042743,0.00051605323,0.00017014271,0.0014483373,0.97548443,0.0024712288,0.0007412859,0.01787705],"study_design_scores_gemma":[0.00021236828,0.00208429,0.0013799792,0.00002814881,0.00005159771,0.00052969245,0.000036466998,0.001260262,0.9770633,0.00023807537,0.017084675,0.00003121577],"about_ca_topic_score_codex":0.0007701941,"about_ca_topic_score_gemma":0.0017405679,"teacher_disagreement_score":0.0030714248,"about_ca_system_score_codex":0.00037686183,"about_ca_system_score_gemma":0.00030525055,"threshold_uncertainty_score":0.010274947},"labels":[],"label_agreement":null},{"id":"W2086663706","doi":"10.1016/j.bmcl.2010.12.014","title":"Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Quinoline; Naphthalene; Stereochemistry; Pharmacology; Carboxamide; Organic chemistry","score_opus":0.0030598577306767617,"score_gpt":0.20767047550047776,"score_spread":0.204610617769801,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2086663706","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97281104,0.020323968,0.0015117947,0.00021105178,0.00012120909,0.00007559414,0.0002006189,0.00008770712,0.00465706],"genre_scores_gemma":[0.9770568,0.014969359,0.0015219172,0.00014788458,0.00009690316,0.000051361323,0.00036352046,0.000015029488,0.00577729],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998981,0.000028338922,0.00000767233,0.000008387826,0.000021770084,0.000035702848],"domain_scores_gemma":[0.9999511,0.0000118583075,0.000012777844,0.0000043451546,0.000005640412,0.000014348484],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030268208,0.00030032187,0.0003737429,0.00027114866,0.00016641586,0.00021182616,0.00040026865,0.00022919335,0.0016539296],"category_scores_gemma":[0.00018493546,0.00022434963,0.00021390857,0.00014873646,0.00022796525,0.00027078492,0.00020412702,0.0005185456,0.00026737674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037623062,0.00032638264,0.00041206589,0.00027704766,0.000066242006,0.0005026709,0.00011916751,0.00070414896,0.95685893,0.0014008202,0.0010088589,0.034561355],"study_design_scores_gemma":[0.0024319442,0.01851837,0.010747857,0.000049211023,0.00041533867,0.0022164294,0.00013840378,0.0035257705,0.9203569,0.00051506946,0.041003954,0.00008071011],"about_ca_topic_score_codex":0.0006765807,"about_ca_topic_score_gemma":0.0026274344,"teacher_disagreement_score":0.0016539296,"about_ca_system_score_codex":0.00018579673,"about_ca_system_score_gemma":0.00017537981,"threshold_uncertainty_score":0.00553298},"labels":[],"label_agreement":null},{"id":"W2087010053","doi":"10.1016/s0960-894x(00)00607-7","title":"Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Chemistry; Human cytomegalovirus; Moiety; Amide; Stereochemistry; Carboxylic acid; Hydrogen bond; Combinatorial chemistry; Chemical synthesis; In vitro; Biochemistry; Molecule; Organic chemistry","score_opus":0.029276321231558062,"score_gpt":0.28055407297691076,"score_spread":0.2512777517453527,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2087010053","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.89074105,0.02281982,0.06547412,0.0005019503,0.00032326972,0.00096672686,0.00090131507,0.0007781879,0.017493628],"genre_scores_gemma":[0.94313407,0.012884525,0.034112327,0.00025676406,0.000074661904,0.00039517457,0.0011738157,0.0000721878,0.00789638],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992394,0.000013294645,0.000006489917,0.000015389996,0.000017058994,0.000023907343],"domain_scores_gemma":[0.99994826,0.000008223556,0.000016405136,0.000004817525,0.0000071906984,0.000015056324],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022034126,0.00057128276,0.00048035398,0.00019786549,0.00018460986,0.00034075908,0.00072385045,0.00032564937,0.0013671442],"category_scores_gemma":[0.0001684925,0.00028155907,0.00027568755,0.00014219031,0.00018665509,0.0003509645,0.000271421,0.0006332724,0.00056884857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034090175,0.00019977837,0.00016045266,0.00040036364,0.00004339837,0.00030020848,0.00010521699,0.0038819476,0.96052206,0.0025263121,0.00067877467,0.030840637],"study_design_scores_gemma":[0.00024013498,0.0020234077,0.00058169925,0.000030214198,0.0000678805,0.00038611965,0.000022885375,0.004351847,0.97379297,0.0003396159,0.018131252,0.00003191027],"about_ca_topic_score_codex":0.00026927318,"about_ca_topic_score_gemma":0.00073365256,"teacher_disagreement_score":0.0013671442,"about_ca_system_score_codex":0.00031312916,"about_ca_system_score_gemma":0.00021275078,"threshold_uncertainty_score":0.0045735836},"labels":[],"label_agreement":null},{"id":"W2087502914","doi":"10.1016/s0960-894x(00)00319-x","title":"Parallel solid-phase synthesis of vitronectin receptor (αvβ3) inhibitors","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Vitronectin; Solid-phase synthesis; Receptor; Stereochemistry; Surface modification; Chemical synthesis; Combinatorial chemistry; Biochemistry; In vitro; Integrin; Peptide","score_opus":0.0056320825220520735,"score_gpt":0.24953382836982724,"score_spread":0.24390174584777516,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2087502914","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7610708,0.007851174,0.1749636,0.0006310953,0.0007618233,0.0014494292,0.0047733216,0.0019109015,0.046587996],"genre_scores_gemma":[0.8878145,0.0049186284,0.087625474,0.000190563,0.000083084815,0.0007156255,0.0028222096,0.00030825596,0.015521711],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997738,0.000028624714,0.000017371272,0.000037582653,0.000095655516,0.000046926198],"domain_scores_gemma":[0.9999255,0.00001640057,0.00001709387,0.000015150845,0.000013171708,0.000012721186],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019821803,0.00051698484,0.0004612889,0.00026710538,0.00024887754,0.00040727522,0.00046436177,0.00026953002,0.002925814],"category_scores_gemma":[0.00020942972,0.00032007118,0.00032254503,0.0004099618,0.00015938097,0.00034066895,0.00033724736,0.00061841455,0.001696701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005223792,0.00020916262,0.000055223725,0.0002237075,0.00003864624,0.00014569008,0.000051706298,0.0044649197,0.9688297,0.0026937865,0.0011804278,0.02158462],"study_design_scores_gemma":[0.00012973508,0.00034267138,0.000092994145,0.0000071719774,0.00001861116,0.00007887013,0.000009704185,0.0035588734,0.9844854,0.0005140801,0.010750183,0.000011734542],"about_ca_topic_score_codex":0.0004948694,"about_ca_topic_score_gemma":0.0013725851,"teacher_disagreement_score":0.002925814,"about_ca_system_score_codex":0.00043841716,"about_ca_system_score_gemma":0.0005933769,"threshold_uncertainty_score":0.009787798},"labels":[],"label_agreement":null},{"id":"W2088289146","doi":"10.1016/j.bmcl.2007.08.010","title":"Thiophene substituted acylguanidines as BACE1 inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Thiophene; Potency; Combinatorial chemistry; Pyrrole; Yield (engineering); Stereochemistry; Förster resonance energy transfer; In vitro; Biochemistry; Organic chemistry; Fluorescence","score_opus":0.015383671369159897,"score_gpt":0.28741154404790165,"score_spread":0.27202787267874173,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088289146","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93120897,0.044479676,0.007071162,0.0009768389,0.000502342,0.0001783914,0.00027926156,0.00041262558,0.014890677],"genre_scores_gemma":[0.96888787,0.020714892,0.0033078745,0.00032814703,0.00009059009,0.000070790484,0.00030326797,0.000036804442,0.006259778],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989927,0.00003264109,0.0000069126268,0.000011695039,0.00002058526,0.000028837077],"domain_scores_gemma":[0.9999474,0.000010652704,0.000010105129,0.0000076041033,0.000010878807,0.000013308544],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027895736,0.00052754604,0.00046230468,0.0003293941,0.00021998883,0.00027693703,0.0004894459,0.00052649865,0.001929146],"category_scores_gemma":[0.00019535034,0.00022934002,0.00023363519,0.00025043162,0.0002683792,0.00042496802,0.00038750458,0.0008660412,0.0005135412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016344099,0.00017311047,0.00027656034,0.00035210032,0.000063596315,0.0008983642,0.00014137424,0.0009669323,0.93648046,0.0027909747,0.0015825306,0.054639604],"study_design_scores_gemma":[0.0005114417,0.004786538,0.0017858868,0.00004965075,0.00012298094,0.0016621643,0.00007907306,0.002050257,0.95452684,0.0007303626,0.03365449,0.00004035211],"about_ca_topic_score_codex":0.0004923884,"about_ca_topic_score_gemma":0.0010506785,"teacher_disagreement_score":0.001929146,"about_ca_system_score_codex":0.00023261187,"about_ca_system_score_gemma":0.00015012443,"threshold_uncertainty_score":0.0064535737},"labels":[],"label_agreement":null},{"id":"W2088490479","doi":"10.1016/s0960-894x(02)00637-6","title":"A multidetachable sulfamate linker successfully used in a solid-Phase strategy to generate libraries of sulfamate and phenol derivatives","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Linker; Phenol; Phenols; Steroid; Enzyme; Side chain; Combinatorial chemistry; Organic chemistry; Stereochemistry; Biochemistry; Polymer; Hormone","score_opus":0.01723387539880022,"score_gpt":0.27056758299542927,"score_spread":0.25333370759662904,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088490479","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94294506,0.0010630888,0.051484767,0.00015874553,0.000055396933,0.00017486472,0.00055294164,0.000458429,0.0031066418],"genre_scores_gemma":[0.9626266,0.0010236708,0.031058563,0.00009254892,0.000014877087,0.000090762325,0.00081795617,0.000081050595,0.004194077],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998202,0.000034006393,0.000013246845,0.000037401467,0.00004869124,0.000046444715],"domain_scores_gemma":[0.999853,0.000027464164,0.00004129777,0.00002297572,0.000022197633,0.000033132466],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029123452,0.00068571646,0.00036402137,0.00031002235,0.00015991529,0.0002902829,0.00039373263,0.00036661472,0.00076322537],"category_scores_gemma":[0.00023667,0.000270233,0.00026216457,0.00037381862,0.00023696512,0.0003522945,0.00040253298,0.0004934201,0.00043995617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012703142,0.000039521517,0.00009223251,0.000042166153,0.000007430315,0.00016082292,0.000028229972,0.00043772458,0.9926609,0.00035523638,0.00006727955,0.0059813485],"study_design_scores_gemma":[0.000019940433,0.00036292954,0.00021990287,0.0000031929255,0.000015080882,0.0002120379,0.00000691162,0.0006359858,0.9966911,0.00006050086,0.0017655266,0.0000069133534],"about_ca_topic_score_codex":0.00040175114,"about_ca_topic_score_gemma":0.000861629,"teacher_disagreement_score":0.00076322537,"about_ca_system_score_codex":0.00029148313,"about_ca_system_score_gemma":0.0003900515,"threshold_uncertainty_score":0.0025532842},"labels":[],"label_agreement":null},{"id":"W2088556991","doi":"10.1016/j.bmcl.2011.08.069","title":"Selectivity of 3′-O-methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo; Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Sucrase; Maltase; Enzyme; Hydrolysis; Selectivity; Biochemistry; Hydrolase; Stereochemistry; Catalysis","score_opus":0.01952629565757957,"score_gpt":0.2536547060130927,"score_spread":0.23412841035551313,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088556991","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98393595,0.0025828346,0.0049887174,0.00017185119,0.00006730097,0.000047068545,0.0002749872,0.00010314017,0.007828119],"genre_scores_gemma":[0.9942847,0.0010323864,0.0014514562,0.000107497435,0.000016615115,0.000020851116,0.0002570732,0.000018310891,0.002811105],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990785,0.000021526126,0.0000044250933,0.000019322504,0.000014027557,0.00003283939],"domain_scores_gemma":[0.9999471,0.000020916814,0.000008755788,0.0000056872896,0.000007591551,0.000009972665],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018673038,0.00024836764,0.00015431922,0.00009023461,0.00010792363,0.00018044509,0.00032670042,0.000339366,0.002373745],"category_scores_gemma":[0.00015617331,0.00014543744,0.00017927172,0.00007977846,0.0001318002,0.0002567177,0.00012481977,0.00036978946,0.00072281953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00033233807,0.000019759822,0.00005987796,0.000022151826,0.0000031071193,0.0000417625,0.000008893226,0.00008812771,0.9967416,0.00018664464,0.0000556574,0.0024401543],"study_design_scores_gemma":[0.000034311564,0.00042154634,0.0005447274,0.0000030365056,0.0000069094704,0.00021359089,0.000007377728,0.0005139442,0.9964096,0.00004772884,0.0017929521,0.000004194316],"about_ca_topic_score_codex":0.0005381831,"about_ca_topic_score_gemma":0.0005976696,"teacher_disagreement_score":0.002373745,"about_ca_system_score_codex":0.00016620226,"about_ca_system_score_gemma":0.00017218562,"threshold_uncertainty_score":0.007941008},"labels":[],"label_agreement":null},{"id":"W2088558054","doi":"10.1016/j.bmcl.2007.03.058","title":"Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: Impacts of glutathione trapping and glucuronide conjugation on covalent binding","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Glutathione; Covalent bond; Glucuronide; In vitro; Indole test; In vivo; Biochemistry; Microsome; Stereochemistry; Metabolism; Enzyme","score_opus":0.010822835176224385,"score_gpt":0.249542578887837,"score_spread":0.23871974371161264,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088558054","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900427,0.0009542826,0.0057250215,0.0001635723,0.000036461734,0.00004297086,0.00008457362,0.00006863463,0.0028817474],"genre_scores_gemma":[0.99674904,0.00037890274,0.0012917065,0.000051835716,0.000006100751,0.000016045125,0.00008311898,0.000011422262,0.0014119766],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998573,0.000051635485,0.0000075340527,0.000020559715,0.0000178473,0.000045109613],"domain_scores_gemma":[0.9999329,0.00001689267,0.000022405802,0.000011470053,0.000008496501,0.000007843903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025228967,0.0002706502,0.00016512527,0.00008376576,0.00017396978,0.00017024876,0.00029004054,0.00026613614,0.0013706171],"category_scores_gemma":[0.00022844502,0.00012387983,0.00019564353,0.00009447027,0.00016071077,0.00022360517,0.00019306714,0.00025595078,0.00025031797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007694072,0.000074645264,0.00032163752,0.00007142073,0.000029528896,0.00011862097,0.000065156935,0.0003826934,0.9893043,0.0011063784,0.0001975308,0.00755867],"study_design_scores_gemma":[0.000021618025,0.00035800814,0.0003305918,0.0000026547182,0.00001392757,0.00007430456,0.000010871491,0.00043533416,0.9972481,0.00004554991,0.0014546977,0.000004291047],"about_ca_topic_score_codex":0.00039002398,"about_ca_topic_score_gemma":0.0010521068,"teacher_disagreement_score":0.0013706171,"about_ca_system_score_codex":0.0002184765,"about_ca_system_score_gemma":0.00017008327,"threshold_uncertainty_score":0.004585147},"labels":[],"label_agreement":null},{"id":"W2088596854","doi":"10.1016/j.bmcl.2008.07.118","title":"Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ryerson University","keywords":"Chemistry; Linker; Antibacterial activity; Combinatorial chemistry; Stereochemistry; Broad spectrum; Oxime; Zero (linguistics); Organic chemistry; Bacteria","score_opus":0.033056657176360256,"score_gpt":0.22684473991227352,"score_spread":0.19378808273591328,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2088596854","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98770183,0.0024565635,0.0069116787,0.00010680294,0.0000315571,0.00010224871,0.00014463864,0.000049579998,0.0024951024],"genre_scores_gemma":[0.9830925,0.0021862115,0.011274982,0.00009628279,0.00001536947,0.00009682488,0.00041087202,0.000017259592,0.0028097574],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990046,0.000017829305,0.000013517088,0.000014916688,0.000026103764,0.000027203794],"domain_scores_gemma":[0.99990344,0.000014472803,0.000027873655,0.000008184616,0.000018329845,0.000027635228],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002813232,0.00028345443,0.0002967768,0.00017977018,0.0001276995,0.00021856253,0.00034242825,0.0002475664,0.0009595915],"category_scores_gemma":[0.0002263107,0.00012730643,0.00013592443,0.00013275958,0.00017317272,0.00023333088,0.00021037937,0.00038578143,0.0002468579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026818857,0.00013138441,0.00021124874,0.00011362568,0.00000715057,0.00010363739,0.00004576572,0.0010198827,0.9865422,0.0005449593,0.000094779134,0.010917203],"study_design_scores_gemma":[0.00006215147,0.0010326036,0.0005846472,0.000009497228,0.000020578384,0.00013217269,0.00001506483,0.0010854729,0.9939302,0.000048945414,0.0030698187,0.00000879793],"about_ca_topic_score_codex":0.0002314175,"about_ca_topic_score_gemma":0.00059342274,"teacher_disagreement_score":0.0009595915,"about_ca_system_score_codex":0.00026136194,"about_ca_system_score_gemma":0.00023467354,"threshold_uncertainty_score":0.003210187},"labels":[],"label_agreement":null},{"id":"W2089441702","doi":"10.1016/j.bmcl.2013.05.045","title":"Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: Discovery of potent succinamide inhibitors","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Directorate for Biological Sciences","keywords":"Chemistry; Protease; Serine protease; Stereochemistry; Cleavage (geology); NS3; Peptide; Serine; Residue (chemistry); Amino acid residue; Proteases; Enzyme inhibitor; Enzyme; Combinatorial chemistry; Peptide sequence; Biochemistry","score_opus":0.011612228490636874,"score_gpt":0.2503413772867504,"score_spread":0.2387291487961135,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2089441702","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.987227,0.002902724,0.0043908036,0.0001681504,0.00006707986,0.00011850744,0.00031502658,0.000076551965,0.0047342014],"genre_scores_gemma":[0.993676,0.002120434,0.002173564,0.00007603077,0.000011361448,0.000021650609,0.0002936394,0.000012037308,0.0016152633],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999502,0.000009485785,0.0000045958973,0.0000072705006,0.000011369046,0.000017139868],"domain_scores_gemma":[0.9999423,0.000008492012,0.000016174718,0.000005619669,0.0000105278405,0.000016860575],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001804315,0.00029121398,0.00021460415,0.00010379381,0.00008470056,0.00020947984,0.00025134682,0.0001640085,0.0011311624],"category_scores_gemma":[0.00015901377,0.00011576623,0.00014743359,0.000101356905,0.00012800685,0.0001992331,0.00015972221,0.00036775833,0.00024341846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00093288557,0.0002321528,0.00049470126,0.00013190607,0.00003775152,0.0004312416,0.000044925284,0.0031919717,0.9665654,0.0007681791,0.0005002984,0.026668685],"study_design_scores_gemma":[0.0005333086,0.004103025,0.0016741019,0.000025905614,0.000063420564,0.00088461733,0.000037898044,0.005115295,0.97702104,0.00020580723,0.010312913,0.000022532251],"about_ca_topic_score_codex":0.0004520178,"about_ca_topic_score_gemma":0.00085196045,"teacher_disagreement_score":0.0011311624,"about_ca_system_score_codex":0.00022593555,"about_ca_system_score_gemma":0.00017280571,"threshold_uncertainty_score":0.0037841797},"labels":[],"label_agreement":null},{"id":"W2089664375","doi":"10.1016/j.bmcl.2009.03.087","title":"The chemoenzymatic synthesis of usnic acid","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Lichen and fungal ecology","field":"Agricultural and Biological Sciences","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Usnic acid; Chemistry; Dibenzofuran; Polyketide; Metabolite; Lichen; Stereochemistry; Organic chemistry; Biochemistry; Enzyme; Biosynthesis; Botany; Biology","score_opus":0.006232744117806219,"score_gpt":0.1808215329171356,"score_spread":0.17458878879932938,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2089664375","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87843525,0.008022703,0.0402295,0.0010511712,0.00069996057,0.00032496042,0.0011407537,0.00047645933,0.06961922],"genre_scores_gemma":[0.98015827,0.003247491,0.007342494,0.0001229851,0.000065702734,0.00005954554,0.0004435119,0.00003697531,0.008523122],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998086,0.00003397248,0.000019018164,0.000026300562,0.000023798497,0.00008824001],"domain_scores_gemma":[0.99992025,0.000009779038,0.000013430888,0.00001707913,0.000017621398,0.000021752945],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026640345,0.0005547254,0.00025637378,0.0004933919,0.00038132246,0.00029181095,0.00039353565,0.00044392797,0.0023800386],"category_scores_gemma":[0.00029234562,0.0001584255,0.00028811544,0.00052822276,0.00027704187,0.00077605486,0.00075846404,0.0006845069,0.0010587288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004935821,0.0004648967,0.00079478225,0.00096524705,0.000060491555,0.0011602932,0.0006703047,0.0037466935,0.83575624,0.021009754,0.0034064022,0.13147132],"study_design_scores_gemma":[0.000032672295,0.00045650237,0.0005490473,0.000022748849,0.000022657354,0.00026106235,0.000058157853,0.00095940096,0.96804374,0.0007434393,0.028826624,0.000023928194],"about_ca_topic_score_codex":0.0011122338,"about_ca_topic_score_gemma":0.0012324696,"teacher_disagreement_score":0.0023800386,"about_ca_system_score_codex":0.0006184009,"about_ca_system_score_gemma":0.0007722368,"threshold_uncertainty_score":0.007962048},"labels":[],"label_agreement":null},{"id":"W2089795538","doi":"10.1016/j.bmcl.2007.03.021","title":"Erratum to “Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron” [Bioorg. Med. Chem. Lett. 17 (2007) 105–108]","year":2007,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Stereochemistry; Plot (graphics); Mathematics","score_opus":0.006544471625563616,"score_gpt":0.23311074414314886,"score_spread":0.22656627251758524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2089795538","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0004545925,0.007714942,0.00092763256,0.033414677,0.94633025,0.00006925334,0.00062321173,0.000243092,0.010222393],"genre_scores_gemma":[0.017626155,0.053933438,0.009479696,0.1420195,0.26208782,0.00032258086,0.006080902,0.0008446957,0.50760525],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99850607,0.00016056396,0.00029747002,0.00016426021,0.00068251794,0.00018912603],"domain_scores_gemma":[0.99699175,0.0007695408,0.00037162204,0.00018989458,0.0013479734,0.00032918688],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015921292,0.0032782804,0.002747489,0.0030488016,0.0026994492,0.0021141667,0.0039304327,0.0069614216,0.027884865],"category_scores_gemma":[0.0074372343,0.0017242925,0.0017363888,0.001565399,0.0014811031,0.0025172492,0.000990936,0.0057266178,0.025916904],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018839048,0.000038988364,0.000065554086,0.0002956261,0.00002633078,0.0007026951,0.000016285661,0.0001162776,0.00087014225,0.00089848,0.98308843,0.01369287],"study_design_scores_gemma":[0.00007981111,0.0000969863,0.0005358233,0.00014722423,0.00007285487,0.00077837583,0.000032923715,0.00022819439,0.0031196931,0.00057525013,0.9942871,0.000045820907],"about_ca_topic_score_codex":0.0048916736,"about_ca_topic_score_gemma":0.009937277,"teacher_disagreement_score":0.027884865,"about_ca_system_score_codex":0.002569686,"about_ca_system_score_gemma":0.0029887708,"threshold_uncertainty_score":0.09328419},"labels":[],"label_agreement":null},{"id":"W2089801141","doi":"10.1016/j.bmcl.2012.10.111","title":"Investigating the binding interactions of galantamine with β-amyloid peptide","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Peptide; Galantamine; Amyloid (mycology); Stereochemistry; Biochemistry; Pharmacology; Donepezil; Internal medicine; Dementia; Disease","score_opus":0.026039030052297265,"score_gpt":0.28525817021356104,"score_spread":0.2592191401612638,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2089801141","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9975579,0.0005197501,0.00065331557,0.00005768138,0.000010032126,0.000009063219,0.000024629384,0.000009123038,0.001158547],"genre_scores_gemma":[0.9975552,0.00031442774,0.0007086023,0.00005802871,0.0000039849033,0.000006653249,0.000063815394,0.00000405325,0.0012853218],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978834,0.000058899415,0.000005887664,0.00003246617,0.0000526035,0.00006195098],"domain_scores_gemma":[0.9998871,0.00005609333,0.000015281732,0.000007983307,0.000016224496,0.000017355109],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024262741,0.0002814839,0.00023571987,0.000121682795,0.000441834,0.00023246887,0.00051823084,0.0005319917,0.0018597762],"category_scores_gemma":[0.00035413489,0.00017657905,0.00033693627,0.00013989942,0.00018970872,0.00035274535,0.00022977537,0.0004971246,0.0003225152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005112206,0.000099263016,0.0006406693,0.0001078592,0.000033885914,0.00023294344,0.000106713174,0.0005494501,0.9953311,0.00020154675,0.000100729405,0.0020845004],"study_design_scores_gemma":[0.000030925337,0.00070163846,0.0036271822,0.000011583428,0.00004193662,0.00054282986,0.00015770186,0.007570866,0.9854953,0.00012605805,0.0016735101,0.000020477471],"about_ca_topic_score_codex":0.0014012228,"about_ca_topic_score_gemma":0.0011720201,"teacher_disagreement_score":0.0018597762,"about_ca_system_score_codex":0.0002783617,"about_ca_system_score_gemma":0.0001644661,"threshold_uncertainty_score":0.0062215924},"labels":[],"label_agreement":null},{"id":"W2090101313","doi":"10.1016/j.bmcl.2009.09.004","title":"Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; U.S. Public Health Service","keywords":"Huntingtin; Chemistry; Nucleic acid; Peptide nucleic acid; DNA; Mutant; Guanine; Peptide; Biochemistry; Fluorescence; RNA; Nucleobase; Molecular biology; Gene; Nucleotide; Biology","score_opus":0.005576552044817098,"score_gpt":0.21440706269505103,"score_spread":0.20883051065023392,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2090101313","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99579155,0.00079057796,0.0019043003,0.00006749714,0.000017428372,0.000007741601,0.000096460004,0.000054963042,0.001269379],"genre_scores_gemma":[0.9975037,0.00033101824,0.00086221175,0.000018755713,0.0000043652713,0.000009634517,0.00012680788,0.000017914039,0.0011255768],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998995,0.000016500926,0.000008349369,0.00002404395,0.00002399504,0.000027611144],"domain_scores_gemma":[0.9998709,0.000052908264,0.000027331658,0.000017934253,0.000009651212,0.00002127512],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013411812,0.00024041836,0.0001632513,0.00012723483,0.00015718171,0.00030032647,0.00022747349,0.0002870839,0.0005049091],"category_scores_gemma":[0.00010757286,0.00016791432,0.00015747861,0.00011831905,0.0002518513,0.00015656321,0.00013071607,0.00041385525,0.00017863169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005849169,0.000012404609,0.00002699123,0.000009206735,0.000001905824,0.000031318228,0.000010143715,0.000052126037,0.99936897,0.00013870548,0.000011822573,0.00027793093],"study_design_scores_gemma":[0.00001205483,0.00011221051,0.00050329714,0.0000011162294,0.000006737904,0.00006475439,0.000008016077,0.0004946219,0.9984553,0.000023295313,0.000317096,0.0000015029451],"about_ca_topic_score_codex":0.00095932,"about_ca_topic_score_gemma":0.0017616132,"teacher_disagreement_score":0.00095932,"about_ca_system_score_codex":0.00035940635,"about_ca_system_score_gemma":0.00020484863,"threshold_uncertainty_score":0.0026076436},"labels":[],"label_agreement":null},{"id":"W2090240368","doi":"10.1016/j.bmcl.2011.12.124","title":"γ-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Analgesic; Cannabinoid; Agonist; Tolerability; Cannabinoid receptor; Pharmacology; Solubility; Oral administration; Cannabinoid receptor type 2; Pharmacokinetics; Medicine; Receptor; Biochemistry; Organic chemistry; Adverse effect","score_opus":0.012605067894901708,"score_gpt":0.24711386031847796,"score_spread":0.23450879242357625,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2090240368","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.88376004,0.05834143,0.018392585,0.0013755629,0.00029888944,0.00034075472,0.0013175452,0.000676084,0.03549697],"genre_scores_gemma":[0.9541411,0.022251355,0.008027985,0.00052157085,0.00006646142,0.00011564345,0.00088052405,0.000054010183,0.013941424],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999354,0.000008159703,0.000005104503,0.000017885293,0.000016713078,0.0000166939],"domain_scores_gemma":[0.9999597,0.000005616402,0.000009003189,0.0000047658928,0.000008743058,0.00001209113],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012539454,0.00040690188,0.0002514077,0.0002591301,0.00020693288,0.00033833776,0.0005954746,0.00034968555,0.0012808692],"category_scores_gemma":[0.00013866217,0.00012915641,0.00015623793,0.00022380867,0.00021630697,0.0003286363,0.00031121608,0.0005731032,0.0008189307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005938091,0.0001124008,0.0001747073,0.00033678958,0.0000127384465,0.00058833545,0.00009553443,0.0004330262,0.94292045,0.0025154904,0.0013287507,0.050888013],"study_design_scores_gemma":[0.00024185804,0.0014821198,0.0013899041,0.00005506811,0.00006429788,0.00361452,0.0000766484,0.0015045153,0.89489293,0.0004930695,0.09612234,0.00006279638],"about_ca_topic_score_codex":0.0010858616,"about_ca_topic_score_gemma":0.0018563062,"teacher_disagreement_score":0.0012808692,"about_ca_system_score_codex":0.00031489728,"about_ca_system_score_gemma":0.00029411833,"threshold_uncertainty_score":0.004284978},"labels":[],"label_agreement":null},{"id":"W2091172878","doi":"10.1016/j.bmcl.2008.12.047","title":"Estradiol dimers as a new class of steroid sulfatase reversible inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Prostate Cancer Foundation","keywords":"Chemistry; Steroid; Steroid sulfatase; Stereochemistry; Potency; Docking (animal); Chemical synthesis; Enzyme inhibitor; In vitro; Biochemistry; Hormone","score_opus":0.007165187532448964,"score_gpt":0.20840983578589783,"score_spread":0.20124464825344887,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2091172878","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.78064054,0.09402491,0.03551117,0.0026703284,0.0016327993,0.00051067764,0.0013781876,0.0012093949,0.082421914],"genre_scores_gemma":[0.885743,0.043865543,0.0083332835,0.0010941998,0.00031438508,0.00028145278,0.0012041754,0.00009214644,0.05907189],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999131,0.000021550784,0.000005366558,0.000018725521,0.000019256287,0.000021896216],"domain_scores_gemma":[0.99996567,0.0000053861095,0.00000646745,0.000004816598,0.000004514926,0.000013131887],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020612491,0.00044841433,0.00037212277,0.0002624617,0.00027859854,0.00035169066,0.00043381838,0.00033341607,0.0032639585],"category_scores_gemma":[0.000117522824,0.000210002,0.00016132307,0.00017701129,0.0001913366,0.00033374873,0.00039491637,0.000607644,0.0011495327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014128592,0.00048448655,0.00049924746,0.000634318,0.000071677656,0.0010114346,0.00026988276,0.0029220856,0.8266155,0.019174708,0.011579033,0.13532476],"study_design_scores_gemma":[0.00052105216,0.0033060543,0.0010637606,0.000053773387,0.000077565084,0.0013604118,0.00007840205,0.0031620234,0.6774103,0.0017928601,0.3111047,0.00006912777],"about_ca_topic_score_codex":0.00018973913,"about_ca_topic_score_gemma":0.00056525116,"teacher_disagreement_score":0.0032639585,"about_ca_system_score_codex":0.00021057302,"about_ca_system_score_gemma":0.00018635187,"threshold_uncertainty_score":0.010918975},"labels":[],"label_agreement":null},{"id":"W2091605564","doi":"10.1016/j.bmcl.2009.09.072","title":"N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: The development of diaryl amino piperidines as potent δ opioid receptor agonists with in vivo anti-nociceptive activity in rodent models","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Agonist; Opioid; Benzamide; Piperidine; Pharmacology; Analgesic; In vivo; δ-opioid receptor; Receptor; Stereochemistry; Opioid receptor; κ-opioid receptor; Functional selectivity; Biochemistry; Medicine","score_opus":0.022036138334176406,"score_gpt":0.24317786154403143,"score_spread":0.22114172320985503,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2091605564","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9492031,0.013516314,0.02307952,0.00041576877,0.00018559357,0.00023622447,0.0006138974,0.0002531449,0.012496513],"genre_scores_gemma":[0.97488177,0.0074776746,0.011202299,0.00017031822,0.00004589726,0.000112971175,0.0003600383,0.00001863947,0.005730312],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999273,0.000011722691,0.000007021005,0.000012428288,0.000016874445,0.000024637176],"domain_scores_gemma":[0.99994767,0.000006937649,0.000018833483,0.0000047231892,0.0000062256627,0.000015674346],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022577298,0.00026628663,0.00020339614,0.00013052787,0.00009457095,0.00011036748,0.0003505166,0.00021344182,0.0019645717],"category_scores_gemma":[0.00015758675,0.00018772777,0.00010513952,0.00010527175,0.00012097924,0.00025217782,0.00014007202,0.0003743416,0.00056800013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004353801,0.0001116185,0.000094754054,0.00019896138,0.000005798691,0.00016676627,0.000027208169,0.00028621135,0.9841493,0.00056165626,0.0002306439,0.013731746],"study_design_scores_gemma":[0.00027854674,0.0036720743,0.0019495359,0.000029742298,0.000033802095,0.0008343921,0.000019777566,0.0015343226,0.98073214,0.00010968499,0.010786232,0.000019784187],"about_ca_topic_score_codex":0.00023731151,"about_ca_topic_score_gemma":0.0008315096,"teacher_disagreement_score":0.0019645717,"about_ca_system_score_codex":0.00018249115,"about_ca_system_score_gemma":0.0001745618,"threshold_uncertainty_score":0.0065721273},"labels":[],"label_agreement":null},{"id":"W2091945867","doi":"10.1016/j.bmcl.2013.03.084","title":"A cyclodextrin-capped histone deacetylase inhibitor","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Oxford Nanopore Technologies","keywords":"Chemistry; Vorinostat; Hydroxamic acid; HDAC8; Histone deacetylase; Histone deacetylase inhibitor; Linker; Stereochemistry; HDAC1; Cyclodextrin; Biochemistry; Histone","score_opus":0.0071796158270524225,"score_gpt":0.24823782594463478,"score_spread":0.24105821011758236,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2091945867","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95599943,0.0064361,0.014490142,0.00059426436,0.000694313,0.0001675164,0.0007844413,0.0008386095,0.019995233],"genre_scores_gemma":[0.9853576,0.0019424926,0.0030464837,0.00024248102,0.000026319873,0.00003197486,0.00052165485,0.000022674913,0.008808246],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994254,0.0000047493177,0.000003328624,0.00001698598,0.000012609289,0.000019714344],"domain_scores_gemma":[0.99997616,0.0000033620754,0.0000041512844,0.000003338738,0.000003254275,0.000009735393],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007844245,0.00024710468,0.00021417222,0.00012012125,0.00013316721,0.00022371118,0.0002739099,0.00026076558,0.0015396872],"category_scores_gemma":[0.00007115953,0.0001236233,0.00012079043,0.0001118161,0.0001024037,0.00014648827,0.00012154559,0.00040803262,0.0005196225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048204677,0.000092614246,0.00010139744,0.000065893604,0.000019724148,0.00013016163,0.000008866053,0.00073030044,0.98740375,0.00047973514,0.0008495095,0.0096359635],"study_design_scores_gemma":[0.000053341595,0.00028497825,0.00043763308,0.000003277659,0.000016722859,0.00013441585,0.0000037070606,0.0012579131,0.98988885,0.000044599143,0.007865714,0.000008898205],"about_ca_topic_score_codex":0.0005482111,"about_ca_topic_score_gemma":0.00073470274,"teacher_disagreement_score":0.0015396872,"about_ca_system_score_codex":0.0003215009,"about_ca_system_score_gemma":0.00020622005,"threshold_uncertainty_score":0.0051507354},"labels":[],"label_agreement":null},{"id":"W2092256340","doi":"10.1016/j.bmcl.2013.05.092","title":"Selective inhibition of human acetylcholinesterase by xanthine derivatives: In vitro inhibition and molecular modeling investigations","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Butyrylcholinesterase; Acetylcholinesterase; Donepezil; Caffeine; IC50; Xanthine; Pharmacology; Cholinesterase; Biochemistry; Pentoxifylline; Aché; Enzyme; Stereochemistry; In vitro; Biology; Dementia","score_opus":0.013983221391553412,"score_gpt":0.2514857665258925,"score_spread":0.23750254513433908,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092256340","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9912236,0.0038426556,0.0035149043,0.000082352686,0.000016073216,0.00001857262,0.00015417836,0.000044318753,0.0011034377],"genre_scores_gemma":[0.9926132,0.0041625,0.0017900292,0.000014570921,0.000006577257,0.00002087897,0.0002326896,0.000008866617,0.0011506713],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991274,0.000023380948,0.0000071158947,0.000015434156,0.000022953243,0.000018303186],"domain_scores_gemma":[0.999944,0.00002142638,0.000017149721,0.0000051511997,0.00000702058,0.0000052366977],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025969325,0.00056674605,0.00029742118,0.00011603602,0.00017408958,0.00022545869,0.00054156233,0.00025953187,0.00068347435],"category_scores_gemma":[0.00018051393,0.00020243783,0.00036324034,0.00015689257,0.0001293788,0.00033653964,0.00014061668,0.00043234866,0.00019940222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006674008,0.00031837964,0.00039499995,0.0002398857,0.00007492154,0.00035767944,0.000117674834,0.015146885,0.97518677,0.0006869947,0.0002092378,0.0065992707],"study_design_scores_gemma":[0.00004714644,0.0012772101,0.00050042366,0.000007891738,0.00006710856,0.0001965779,0.000025532605,0.024145985,0.9723938,0.00005621206,0.0012698992,0.000012165664],"about_ca_topic_score_codex":0.0011699995,"about_ca_topic_score_gemma":0.0009571932,"teacher_disagreement_score":0.0011699995,"about_ca_system_score_codex":0.00028292928,"about_ca_system_score_gemma":0.00011737533,"threshold_uncertainty_score":0.0023263097},"labels":[],"label_agreement":null},{"id":"W2092264166","doi":"10.1016/j.bmcl.2013.09.030","title":"Investigation of aryl halides as ketone bioisosteres: Refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Bioisostere; Chemistry; Ketone; Pharmacophore; Aryl; Aromatase; Stereochemistry; Cytochrome P450; Halide; Chemical synthesis; Combinatorial chemistry; Alkyl; Enzyme; Organic chemistry; In vitro; Biochemistry","score_opus":0.007499034202034637,"score_gpt":0.2127214589456701,"score_spread":0.20522242474363547,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092264166","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97206086,0.010684942,0.0068766456,0.00029684324,0.000077201854,0.0002816482,0.0009426766,0.00018525714,0.008593964],"genre_scores_gemma":[0.97766227,0.010925712,0.0043038307,0.0001351761,0.000035036122,0.00007621522,0.0011527912,0.00004684079,0.0056621986],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998554,0.00003303039,0.000013027312,0.000021805243,0.000041148283,0.000035640052],"domain_scores_gemma":[0.9998714,0.000025074112,0.000020649295,0.000018641496,0.00003219549,0.000032083066],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004208736,0.0004920158,0.0004134304,0.00031808473,0.00020311959,0.00030777272,0.00057645456,0.0002276679,0.001826674],"category_scores_gemma":[0.00032996424,0.00021664525,0.00029323107,0.00026223532,0.00024243153,0.00030193906,0.00029371146,0.00055597204,0.0005190997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0020500878,0.0007781233,0.0013132803,0.00036473936,0.00011292431,0.00058631564,0.00017642288,0.0045344355,0.948046,0.0016388396,0.0009682995,0.03943048],"study_design_scores_gemma":[0.0005518674,0.005449355,0.0016594332,0.000018668934,0.00019515445,0.0009072899,0.000076866396,0.0023562799,0.97066826,0.0002067761,0.017885933,0.000024109773],"about_ca_topic_score_codex":0.0017655821,"about_ca_topic_score_gemma":0.0033718306,"teacher_disagreement_score":0.001826674,"about_ca_system_score_codex":0.0003355177,"about_ca_system_score_gemma":0.00037438067,"threshold_uncertainty_score":0.006110847},"labels":[],"label_agreement":null},{"id":"W2092419797","doi":"10.1016/j.bmcl.2004.01.064","title":"Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Autophosphorylation; Insulin receptor; Chemistry; Insulin; Receptor; IRS2; Insulin receptor substrate; Stereochemistry; Biochemistry; Insulin resistance; Endocrinology; Biology; Kinase","score_opus":0.05265521156986144,"score_gpt":0.2386129154874279,"score_spread":0.18595770391756647,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092419797","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.52516985,0.00050501735,0.4641129,0.00043421064,0.00009002027,0.0002601165,0.00027963825,0.0017396823,0.007408581],"genre_scores_gemma":[0.75354517,0.0002839823,0.2432145,0.00009612863,0.000010952974,0.00015178017,0.00029324315,0.00014826377,0.0022559166],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.999936,0.000014719909,0.0000038950984,0.00001538807,0.000016182405,0.000013743133],"domain_scores_gemma":[0.9998858,0.000036429497,0.000021425665,0.000011774337,0.00002842142,0.000016122784],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022494314,0.00038810362,0.0005242532,0.00023387947,0.00027543455,0.0006528019,0.0005575654,0.00046190163,0.0012916108],"category_scores_gemma":[0.00039090056,0.0003874135,0.0004132462,0.00016555787,0.00022049449,0.00020868938,0.00031394162,0.00047680872,0.00027852552],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032456056,0.00022332223,0.001187293,0.00021283538,0.000055356362,0.00034313207,0.00013538526,0.6818529,0.23573448,0.013132497,0.0013941163,0.06540417],"study_design_scores_gemma":[0.000091947215,0.0002281387,0.00013664199,0.0000053521435,0.000028458668,0.00006760432,0.000046891157,0.9385664,0.05615337,0.0012312848,0.0034279635,0.000016041653],"about_ca_topic_score_codex":0.0016120265,"about_ca_topic_score_gemma":0.002967128,"teacher_disagreement_score":0.0016120265,"about_ca_system_score_codex":0.0006345853,"about_ca_system_score_gemma":0.00077865156,"threshold_uncertainty_score":0.0046042204},"labels":[],"label_agreement":null},{"id":"W2092861486","doi":"10.1016/j.bmcl.2007.12.057","title":"4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; HDAC1; Acetylation; In vivo; In vitro; Downregulation and upregulation; Chemical synthesis; Histone; Stereochemistry; Biochemistry; Cancer research; Pharmacology; Gene","score_opus":0.010120822950027393,"score_gpt":0.27926724353405774,"score_spread":0.2691464205840303,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092861486","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8919924,0.03724089,0.023879427,0.00075623713,0.0005607472,0.00025482132,0.00060435536,0.00060723646,0.04410391],"genre_scores_gemma":[0.96991426,0.012010509,0.006690139,0.0002656332,0.00013524185,0.00013477048,0.00043137808,0.000032068117,0.0103858905],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998884,0.00002605997,0.000006191368,0.000016288983,0.000025328649,0.000037801638],"domain_scores_gemma":[0.9999559,0.0000062723293,0.000013994691,0.000004558797,0.000006594831,0.000012742967],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020351872,0.0003111962,0.0003402804,0.00019960004,0.00017911948,0.00022445511,0.0006108269,0.00031719657,0.0024574695],"category_scores_gemma":[0.00012139513,0.0001556837,0.00018004964,0.00017441972,0.00017644542,0.0002719326,0.00020695024,0.0004745635,0.0006639014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008091296,0.00024675942,0.00023236965,0.0002780448,0.00002590258,0.0004300184,0.00007087624,0.001462246,0.9569514,0.004100972,0.0011344688,0.03425782],"study_design_scores_gemma":[0.00041225174,0.004303483,0.0025476415,0.000038527713,0.0000717708,0.0010683701,0.000045397388,0.003796286,0.93853855,0.0005111767,0.048621174,0.000045389508],"about_ca_topic_score_codex":0.0006067349,"about_ca_topic_score_gemma":0.0015277141,"teacher_disagreement_score":0.0024574695,"about_ca_system_score_codex":0.0002848583,"about_ca_system_score_gemma":0.00023213639,"threshold_uncertainty_score":0.00822103},"labels":[],"label_agreement":null},{"id":"W2093248826","doi":"10.1016/j.bmcl.2007.12.009","title":"Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; Stereochemistry; Chemical synthesis; Combinatorial chemistry; In vitro; Histone; Biochemistry","score_opus":0.013417573025702054,"score_gpt":0.27394968836885186,"score_spread":0.2605321153431498,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093248826","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92097515,0.011434071,0.041503333,0.00063299946,0.00042195196,0.0009105643,0.0009891678,0.0005221384,0.022610655],"genre_scores_gemma":[0.9613839,0.006596353,0.021018898,0.00015968092,0.00008321804,0.00034578485,0.0008519593,0.00004941676,0.009510907],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998567,0.000029845034,0.000013272191,0.00002325227,0.000031176223,0.000045758257],"domain_scores_gemma":[0.99992037,0.000007908642,0.000023797207,0.000007004932,0.000016540991,0.000024336094],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030072758,0.00038251793,0.00044990773,0.00022744246,0.00016853557,0.00032801557,0.0007626466,0.00032168394,0.0020107795],"category_scores_gemma":[0.00020847043,0.0002726179,0.0002566492,0.0001946891,0.00019539223,0.00023881273,0.0001986532,0.00045874735,0.0007078599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044551154,0.0001951927,0.00012242602,0.00025498893,0.000026395383,0.0002509548,0.000082329534,0.0019869083,0.9771553,0.002297582,0.0004581326,0.016724108],"study_design_scores_gemma":[0.0004184788,0.0025951436,0.0008545414,0.00002402593,0.000061973,0.00040259337,0.000025928426,0.003054281,0.96944827,0.00017249529,0.02291043,0.000031815132],"about_ca_topic_score_codex":0.00065489,"about_ca_topic_score_gemma":0.0014496931,"teacher_disagreement_score":0.0020107795,"about_ca_system_score_codex":0.00037924876,"about_ca_system_score_gemma":0.00041090595,"threshold_uncertainty_score":0.006726742},"labels":[],"label_agreement":null},{"id":"W2093417691","doi":"10.1016/j.bmcl.2009.05.061","title":"Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Benzimidazole; Chemistry; Linker; Antimicrobial; In vitro; Combinatorial chemistry; Antibacterial activity; Staphylococcus aureus; Antibacterial agent; Stereochemistry; Antibiotics; Chemical synthesis; Bacteria; Biochemistry; Organic chemistry","score_opus":0.007304072665159386,"score_gpt":0.22276488125206828,"score_spread":0.2154608085869089,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093417691","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9832782,0.002015347,0.009565373,0.00015357186,0.00007605578,0.00019281378,0.0003121923,0.00013699835,0.0042694625],"genre_scores_gemma":[0.98828644,0.0008618379,0.00893269,0.00010428015,0.000016897815,0.00006448958,0.00030800543,0.000022041386,0.0014033306],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998216,0.000032098425,0.000019602332,0.00003377953,0.00004428763,0.000048625272],"domain_scores_gemma":[0.9998361,0.000022075952,0.000061582294,0.0000127684925,0.000034275712,0.000033146567],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031468357,0.0004899524,0.00032533283,0.0002115083,0.00019739986,0.00020491093,0.00045811108,0.00033929356,0.0018166553],"category_scores_gemma":[0.00033034477,0.00018699924,0.00020367306,0.00022403307,0.00015552656,0.00029412564,0.00025171012,0.0003866603,0.00050387345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008685717,0.00015937138,0.00026739185,0.00025379076,0.000030886215,0.00030278583,0.000050890612,0.0036698196,0.98054874,0.00085292786,0.00027040762,0.012724506],"study_design_scores_gemma":[0.00023732388,0.0016964615,0.0008555417,0.000029777373,0.00006176839,0.00031408446,0.00002843044,0.0027280655,0.98712873,0.00011281697,0.0067805513,0.00002640825],"about_ca_topic_score_codex":0.00070077094,"about_ca_topic_score_gemma":0.0017392185,"teacher_disagreement_score":0.0018166553,"about_ca_system_score_codex":0.0004305965,"about_ca_system_score_gemma":0.0005031231,"threshold_uncertainty_score":0.006077349},"labels":[],"label_agreement":null},{"id":"W2093609582","doi":"10.1016/j.bmcl.2004.01.101","title":"Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Photoaffinity labeling; Enzyme; Stereochemistry; Chemical synthesis; Enzyme inhibitor; Combinatorial chemistry; Biochemistry; Binding site; In vitro","score_opus":0.014122732523476046,"score_gpt":0.23529512038480696,"score_spread":0.22117238786133092,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093609582","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.79368865,0.011463391,0.17157029,0.0029884342,0.0005679246,0.00052824034,0.0015634259,0.0010313874,0.016598292],"genre_scores_gemma":[0.9116548,0.0036237582,0.06408821,0.0011664417,0.0001401193,0.00022343433,0.0018261945,0.000103624385,0.017173328],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981385,0.000029139888,0.000006208916,0.000051703806,0.000041377203,0.000057796497],"domain_scores_gemma":[0.99987864,0.000028797047,0.000018655111,0.000010769294,0.0000135033415,0.00004954541],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025506577,0.00050928904,0.00054989045,0.00024660453,0.0004795241,0.00040931377,0.0006519526,0.0010307599,0.002425732],"category_scores_gemma":[0.00023735472,0.00041811517,0.00028856902,0.00023496416,0.00023072836,0.00032367156,0.00043331558,0.0015155222,0.0013088894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007349726,0.000037929534,0.00004527892,0.00008501766,0.000008326864,0.00012904842,0.000025668884,0.00018031446,0.99480695,0.00036839896,0.0002876494,0.0039518694],"study_design_scores_gemma":[0.00003760873,0.00023083885,0.00038298615,0.000006387673,0.000012695689,0.00037087032,0.0000124519365,0.0007141789,0.99058527,0.00012490955,0.007507389,0.000014414321],"about_ca_topic_score_codex":0.000744842,"about_ca_topic_score_gemma":0.001780515,"teacher_disagreement_score":0.002425732,"about_ca_system_score_codex":0.0006551042,"about_ca_system_score_gemma":0.00051308377,"threshold_uncertainty_score":0.008114874},"labels":[],"label_agreement":null},{"id":"W2093715655","doi":"10.1016/j.bmcl.2013.02.040","title":"A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: Synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chronotropic; Chemistry; Nitric oxide; Inotrope; Nitroxyl; Pharmacology; Heart rate; Blood pressure; Internal medicine; Organic chemistry; Medicine","score_opus":0.008691974881164504,"score_gpt":0.22438989373115228,"score_spread":0.2156979188499878,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093715655","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9846911,0.004474875,0.0030632967,0.00013796843,0.00013522751,0.00011189765,0.00029780893,0.00005456109,0.0070332633],"genre_scores_gemma":[0.99086374,0.0023863409,0.002843939,0.00010880327,0.000041145246,0.000050283812,0.00034485894,0.000012089726,0.0033488737],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999436,0.000011919909,0.000004331473,0.000010896593,0.000011178278,0.00001809418],"domain_scores_gemma":[0.99993694,0.000009494267,0.0000107146925,0.0000052392184,0.000008275228,0.000029414687],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010923835,0.00015150914,0.00021968552,0.00019804253,0.00012644684,0.00009699296,0.00026599964,0.00020419847,0.0010670018],"category_scores_gemma":[0.00010438908,0.00008418135,0.000080230944,0.00011198747,0.00013975077,0.00011405886,0.000092763185,0.00030377688,0.00027260985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003910709,0.000061493876,0.00006699817,0.000051956566,0.000004143482,0.000115315976,0.000014440096,0.00011833116,0.99568766,0.00017120595,0.000047857877,0.0032695378],"study_design_scores_gemma":[0.00025975856,0.0059849005,0.0024467108,0.00001725271,0.00002861275,0.00076515117,0.000030853636,0.00059299864,0.98178536,0.00010118304,0.007970307,0.000016963426],"about_ca_topic_score_codex":0.00046793162,"about_ca_topic_score_gemma":0.0008651126,"teacher_disagreement_score":0.0010670018,"about_ca_system_score_codex":0.0001445879,"about_ca_system_score_gemma":0.00021941254,"threshold_uncertainty_score":0.0035694838},"labels":[],"label_agreement":null},{"id":"W2093766523","doi":"10.1016/j.bmcl.2005.07.036","title":"Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cyclooxygenase; Potency; IC50; Arachidonate 5-lipoxygenase; Lipoxygenase; Stereochemistry; Enzyme inhibitor; Enzyme; Pharmacology; Biochemistry; In vitro; Arachidonic acid","score_opus":0.018687874327401505,"score_gpt":0.2581715643292316,"score_spread":0.2394836900018301,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093766523","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9541621,0.019332645,0.011836839,0.00048887415,0.00031349502,0.00041803857,0.0012242753,0.00016687156,0.01205681],"genre_scores_gemma":[0.9745715,0.010300974,0.0066503426,0.00014518425,0.00006164473,0.00021799997,0.00074687676,0.00002596626,0.0072794524],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998846,0.000020185114,0.0000128355805,0.000016696476,0.00002244998,0.0000432269],"domain_scores_gemma":[0.9999292,0.00001288697,0.000012605815,0.0000060615594,0.000011011851,0.000028306986],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027611235,0.0004994617,0.00040520378,0.0003863007,0.00021858048,0.00031753938,0.00042162955,0.00035353363,0.0022380648],"category_scores_gemma":[0.00018448212,0.00028950183,0.00023215785,0.00020025771,0.00019467497,0.00034616582,0.00029817387,0.0006930811,0.00058824423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010354058,0.0002790887,0.00013412129,0.00034793024,0.000026176249,0.00046607968,0.00007303761,0.0010872298,0.9816606,0.0014079792,0.0003818465,0.013100513],"study_design_scores_gemma":[0.0004324787,0.0037595783,0.001099413,0.00003301359,0.000075969685,0.00045008,0.000034055935,0.0015001021,0.9792331,0.00021402369,0.013142381,0.000025826464],"about_ca_topic_score_codex":0.00039023336,"about_ca_topic_score_gemma":0.00082306727,"teacher_disagreement_score":0.0022380648,"about_ca_system_score_codex":0.0002455216,"about_ca_system_score_gemma":0.00035550876,"threshold_uncertainty_score":0.0074870586},"labels":[],"label_agreement":null},{"id":"W2094555441","doi":"10.1016/j.bmcl.2008.11.055","title":"New analogues of agmatine with higher affinity to imidazoline receptors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Agmatine; Imidazoline receptor; Chemistry; Receptor; Pharmacology; Stereochemistry; Biochemistry; Enzyme","score_opus":0.010447402626664881,"score_gpt":0.21747116844412168,"score_spread":0.2070237658174568,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2094555441","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9716386,0.007839386,0.0059808637,0.00040452593,0.00023582786,0.00014384392,0.0004186374,0.00030129895,0.013036966],"genre_scores_gemma":[0.9891362,0.0017996576,0.0037385803,0.00024374748,0.00005648513,0.00004854397,0.00032356026,0.000033382083,0.004619935],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998957,0.000025992997,0.000009097932,0.000020024838,0.000014685133,0.000034594304],"domain_scores_gemma":[0.9998678,0.000032456923,0.000032731583,0.000016286036,0.000017227669,0.00003340161],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003515,0.00031515225,0.000518039,0.00018715872,0.00018601601,0.00046832714,0.0007873774,0.00048043206,0.0029734573],"category_scores_gemma":[0.00025911673,0.0001449779,0.000190845,0.00016629815,0.00021815655,0.0004310548,0.00020189426,0.0008187173,0.00063904276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013551315,0.00012371833,0.0001420971,0.00022403843,0.000022854338,0.0003208664,0.000115958464,0.00042847043,0.9812199,0.0025373616,0.0005006259,0.013009064],"study_design_scores_gemma":[0.00079882785,0.00576416,0.0023142013,0.000028331426,0.00011213047,0.0017011685,0.00006824889,0.0023666332,0.9500015,0.00051225297,0.036271963,0.000060691054],"about_ca_topic_score_codex":0.00039124317,"about_ca_topic_score_gemma":0.00070381816,"teacher_disagreement_score":0.0029734573,"about_ca_system_score_codex":0.0004961653,"about_ca_system_score_gemma":0.00012089724,"threshold_uncertainty_score":0.00994724},"labels":[],"label_agreement":null},{"id":"W2094758813","doi":"10.1016/s0960-894x(03)00790-x","title":"Synthesis and in vitro analysis of atrial natriuretic peptide–albumin conjugates","year":2003,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"ConjuChem (Canada)","funders":"","keywords":"Chemistry; Atrial natriuretic peptide; Conjugate; In vitro; Peptide; Albumin; NPR1; Receptor; Cysteine; Peptide hormone; NPR2; Conjugated system; Serum albumin; Bovine serum albumin; Biochemistry; Internal medicine; Natriuretic peptide; Enzyme","score_opus":0.009573257605917151,"score_gpt":0.23403082364882108,"score_spread":0.22445756604290393,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2094758813","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9660475,0.0023986537,0.028204054,0.00015107336,0.0000628242,0.0001561984,0.00044001138,0.00008892637,0.0024506254],"genre_scores_gemma":[0.9827874,0.001091001,0.009745971,0.00007988494,0.000024739391,0.00009171081,0.00091545796,0.0000336699,0.005230289],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997702,0.00007264574,0.000019408708,0.000034286957,0.00005252259,0.00005085855],"domain_scores_gemma":[0.9998361,0.000059712096,0.000036951937,0.000017350863,0.000026259431,0.000023633454],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003776669,0.00045340805,0.00030502712,0.00018498642,0.0002228987,0.00021628097,0.00023638766,0.00032630915,0.0011249636],"category_scores_gemma":[0.00029223305,0.00021055536,0.00026418822,0.00021131741,0.00014992844,0.00022003897,0.00015484351,0.00040550498,0.00035919758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021612155,0.00006216464,0.000056084962,0.000035382833,0.000008052819,0.00008984679,0.000024260913,0.00024870504,0.99758554,0.00010194869,0.00003677339,0.0015351226],"study_design_scores_gemma":[0.000014773173,0.00026326498,0.00023223394,0.0000012891455,0.000007822364,0.00008473634,0.000004562953,0.00033887412,0.9983032,0.000018739498,0.00072811765,0.0000024280669],"about_ca_topic_score_codex":0.00037035975,"about_ca_topic_score_gemma":0.0005078386,"teacher_disagreement_score":0.0011249636,"about_ca_system_score_codex":0.00031392873,"about_ca_system_score_gemma":0.00015515611,"threshold_uncertainty_score":0.0037634373},"labels":[],"label_agreement":null},{"id":"W2095003522","doi":"10.1016/j.bmcl.2004.12.015","title":"Synthesis of half-mustard combi-molecules with fluorescence properties: correlation with EGFR status","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Royal Victoria Hospital; McGill University","funders":"National Cancer Institute","keywords":"Chemistry; Fluorescence; Flow cytometry; Tyrosine kinase; DNA; Cell culture; Biophysics; Biochemistry; Molecular biology; Signal transduction; Genetics; Biology","score_opus":0.007645262843477032,"score_gpt":0.18902605904125616,"score_spread":0.18138079619777914,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2095003522","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9821524,0.0011700741,0.012462022,0.00016461778,0.000042561904,0.00019989298,0.00044228305,0.00017029958,0.0031958818],"genre_scores_gemma":[0.9844328,0.0003596793,0.0112081235,0.00006700289,0.000010616603,0.00010100986,0.0003294395,0.000034132874,0.003457289],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999149,0.000013580661,0.000008564897,0.00002192231,0.00001855497,0.000022473709],"domain_scores_gemma":[0.99986947,0.00003127537,0.000032642576,0.00002131831,0.000022063052,0.000023156126],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370928,0.00016510763,0.00030239567,0.00021839091,0.00015423141,0.00022645446,0.00026123988,0.00031008266,0.0018539167],"category_scores_gemma":[0.0003114755,0.00015288607,0.00012157805,0.00018231566,0.000117837815,0.00027124071,0.00016224556,0.0002744319,0.00042538752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021425358,0.00005039456,0.00025445595,0.000044741988,0.00001008093,0.000076182536,0.000052592797,0.00027121592,0.98980296,0.000669911,0.00015899623,0.008394189],"study_design_scores_gemma":[0.000039366314,0.00026706897,0.0007421414,0.0000018540392,0.000011337541,0.000105236344,0.0000064562532,0.0010167584,0.9951984,0.00007751114,0.0025265384,0.000007251557],"about_ca_topic_score_codex":0.000219109,"about_ca_topic_score_gemma":0.00050031533,"teacher_disagreement_score":0.0018539167,"about_ca_system_score_codex":0.00022389916,"about_ca_system_score_gemma":0.00017246629,"threshold_uncertainty_score":0.0062019825},"labels":[],"label_agreement":null},{"id":"W2095049107","doi":"10.1016/j.bmcl.2013.01.068","title":"Design, synthesis and structure–activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency","funders":"National Institute of Biomedical Imaging and Bioengineering","keywords":"Pharmacophore; Chemistry; Binding affinities; Rhenium; Chelation; Affinities; Combinatorial chemistry; Stereochemistry; Fibril; Organic chemistry; Biochemistry","score_opus":0.0308008028821271,"score_gpt":0.27409054359363616,"score_spread":0.24328974071150905,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2095049107","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98185396,0.006052849,0.007946875,0.00018594199,0.00004141775,0.00019076091,0.00021749521,0.00010085301,0.0034098763],"genre_scores_gemma":[0.98806787,0.0039122524,0.0045949966,0.000066638495,0.00001589742,0.000054890133,0.00021672605,0.000012251394,0.0030585434],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993396,0.000017689834,0.000005945135,0.000009507949,0.000013236255,0.000019636045],"domain_scores_gemma":[0.99995255,0.000008589056,0.0000152426755,0.000004565173,0.000010221238,0.000008756205],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021040424,0.00023169811,0.0002163183,0.00017126084,0.0001253448,0.00022010569,0.00033748648,0.0001692351,0.0009152282],"category_scores_gemma":[0.00016288467,0.00015467455,0.00016483173,0.00016448113,0.000116602474,0.00012374925,0.0001250658,0.0002992438,0.000299471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038615675,0.00016058408,0.00024376383,0.00014412013,0.000017479539,0.00015948643,0.000063339816,0.0015758891,0.9862177,0.00054999813,0.00017384521,0.010307564],"study_design_scores_gemma":[0.00017164608,0.0018901617,0.0014669861,0.000011821361,0.000046865545,0.00022049609,0.000021189751,0.0026337132,0.9865807,0.00006991581,0.006874462,0.000012167891],"about_ca_topic_score_codex":0.00071848015,"about_ca_topic_score_gemma":0.0019605006,"teacher_disagreement_score":0.0009152282,"about_ca_system_score_codex":0.00026283856,"about_ca_system_score_gemma":0.00018673555,"threshold_uncertainty_score":0.0030617714},"labels":[],"label_agreement":null},{"id":"W2095076784","doi":"10.1016/j.bmcl.2011.02.021","title":"C20-trifluoro-5-oxo-ETE: A metabolically stable 5-oxo-ETE derivative","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Reactions of Organic Compounds","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Chemistry; Derivative (finance); Stereochemistry; Combinatorial chemistry; Chemical synthesis; In vitro; Biochemistry","score_opus":0.023405797713066813,"score_gpt":0.20764444737602727,"score_spread":0.18423864966296047,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2095076784","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91284955,0.0072129257,0.03330929,0.0014830021,0.0005932418,0.00029059773,0.0032022032,0.0008902048,0.040168993],"genre_scores_gemma":[0.9793258,0.0016718269,0.005760662,0.00019879677,0.00003765288,0.00006235002,0.0008273827,0.000055540513,0.012059918],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998179,0.000028059962,0.000011470396,0.00003824228,0.000025435618,0.000079002144],"domain_scores_gemma":[0.99991906,0.000011723143,0.00001638455,0.000012756311,0.000011721991,0.000028466231],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032646596,0.0004938156,0.00028647148,0.00026545595,0.00023974743,0.00022161873,0.00051838893,0.00063778635,0.0043427325],"category_scores_gemma":[0.00019616375,0.00014692485,0.00023142148,0.00018372886,0.00028796715,0.00049853895,0.00033627744,0.000481534,0.0015024099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015696444,0.00019791507,0.00022353858,0.00023747429,0.00002254013,0.0010508619,0.00010746068,0.0011076917,0.9727625,0.0030576636,0.0013207273,0.018341886],"study_design_scores_gemma":[0.00011301961,0.0014140183,0.0007161035,0.000013284181,0.000018864464,0.0009633484,0.00003186047,0.0005296319,0.97619116,0.00018928919,0.019793293,0.000026117958],"about_ca_topic_score_codex":0.00080236455,"about_ca_topic_score_gemma":0.0006265945,"teacher_disagreement_score":0.0043427325,"about_ca_system_score_codex":0.0004067489,"about_ca_system_score_gemma":0.00029472355,"threshold_uncertainty_score":0.014527917},"labels":[],"label_agreement":null},{"id":"W2095103987","doi":"10.1016/j.bmcl.2006.07.074","title":"Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Benzimidazole; Chemistry; Replicon; Allosteric regulation; Hepatitis C virus; RNA polymerase; Polymerase; Indole test; Stereochemistry; Virology; Enzyme; Biochemistry; Virus; RNA; Biology; Hepacivirus","score_opus":0.008459677690689796,"score_gpt":0.24628398946627866,"score_spread":0.23782431177558888,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2095103987","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900919,0.002058537,0.0032492431,0.0001315661,0.00004026082,0.000035639936,0.00025401908,0.00021234291,0.0039263945],"genre_scores_gemma":[0.995833,0.0007215172,0.001334212,0.000028656088,0.000007958373,0.000012652916,0.0002696483,0.000017488272,0.0017749524],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994326,0.000009616279,0.00000424485,0.000008495244,0.0000102869935,0.000024112098],"domain_scores_gemma":[0.9999566,0.000011570457,0.000008536111,0.000007634532,0.0000062808995,0.000009290831],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015914315,0.00025936886,0.00020216279,0.0001454767,0.00013796121,0.00023675757,0.0002716499,0.00018229359,0.0013828422],"category_scores_gemma":[0.00012735598,0.000103573446,0.0001773336,0.0001263079,0.00013663825,0.00017884796,0.00013532978,0.00037165833,0.00030910157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031588267,0.00007848429,0.0001094812,0.00005436723,0.0000039356755,0.000072722265,0.0000392753,0.00042777864,0.9929582,0.00029374228,0.00014170933,0.0055044675],"study_design_scores_gemma":[0.00004457391,0.0006058111,0.0009634386,0.0000045579304,0.0000149418565,0.00007677701,0.000009712712,0.0010461268,0.9951095,0.00003030822,0.0020874417,0.0000068059494],"about_ca_topic_score_codex":0.0015049994,"about_ca_topic_score_gemma":0.0035118973,"teacher_disagreement_score":0.0015049994,"about_ca_system_score_codex":0.0003724683,"about_ca_system_score_gemma":0.00020597952,"threshold_uncertainty_score":0.0046260357},"labels":[],"label_agreement":null},{"id":"W2096210836","doi":"10.1016/j.bmcl.2005.07.072","title":"Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Cytotoxic T cell; Cell culture; Cytotoxicity; Combinatorial chemistry; Cell growth; Cancer cell; Cell cycle checkpoint; Cell cycle; In vitro; Stereochemistry; Cell; Biochemistry; Cancer","score_opus":0.04654943090218015,"score_gpt":0.2779115750975344,"score_spread":0.23136214419535422,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2096210836","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9771263,0.004510623,0.011241533,0.00014670863,0.00010837349,0.00041389058,0.00066934136,0.00023541991,0.0055477936],"genre_scores_gemma":[0.982635,0.0030023323,0.008426479,0.00004805578,0.00003319406,0.0002117041,0.0010401041,0.00004814449,0.004554977],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998555,0.000030514635,0.000017408882,0.000025906773,0.00003561369,0.00003504688],"domain_scores_gemma":[0.9998802,0.000019206613,0.0000194032,0.000024050272,0.000029130319,0.000028044133],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024470923,0.00038140916,0.0004942448,0.00034817116,0.00026770914,0.00021986761,0.00037733957,0.00030758497,0.0013650735],"category_scores_gemma":[0.00018878773,0.00016113411,0.00020233191,0.00034657592,0.00020109964,0.00017102683,0.00019493038,0.00033731182,0.00040746882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020181669,0.000080231366,0.000049848386,0.00005917379,0.0000075658486,0.000063536725,0.000030919236,0.00027110334,0.99420553,0.00018408505,0.00008353051,0.004762663],"study_design_scores_gemma":[0.00006009589,0.00069727044,0.0003178063,0.000001983969,0.00002194989,0.00008995807,0.0000072953967,0.00021420872,0.99651104,0.000024473798,0.0020500731,0.000003828024],"about_ca_topic_score_codex":0.0007104056,"about_ca_topic_score_gemma":0.001735484,"teacher_disagreement_score":0.0013650735,"about_ca_system_score_codex":0.0003669453,"about_ca_system_score_gemma":0.00040745715,"threshold_uncertainty_score":0.00456661},"labels":[],"label_agreement":null},{"id":"W2096679957","doi":"10.1016/j.bmcl.2003.11.076","title":"Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Protein tyrosine phosphatase; Structure–activity relationship; Stereochemistry; Selectivity; Benzotriazole; Enzyme inhibitor; Molecular model; Lead compound; Crystal structure; Chemical synthesis; In vitro; Enzyme; Biochemistry; Organic chemistry","score_opus":0.004832755718077259,"score_gpt":0.19265388471840658,"score_spread":0.18782112900032932,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2096679957","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9290785,0.016512295,0.035601143,0.0010120984,0.00033002565,0.0009900684,0.0014352055,0.0005591113,0.014481501],"genre_scores_gemma":[0.9637034,0.008367491,0.018625567,0.00041579938,0.00004774632,0.00027396096,0.0016444221,0.0000398878,0.0068816594],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998996,0.000013929049,0.000007851305,0.000017368126,0.00003081192,0.000030488896],"domain_scores_gemma":[0.9999503,0.000005047404,0.000013465343,0.0000030485921,0.0000089242885,0.000019231456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761593,0.00053007127,0.0005657341,0.00029659833,0.00023932243,0.00051990314,0.0006745128,0.00032507398,0.0016443634],"category_scores_gemma":[0.00020290122,0.00031903383,0.00024450076,0.0001872119,0.00017925703,0.00024695558,0.00027092308,0.0008313452,0.00048115966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009108382,0.00056716026,0.00045566174,0.00034065152,0.000086079934,0.0005345508,0.000074361684,0.013607621,0.9354055,0.003451843,0.0017339982,0.04283176],"study_design_scores_gemma":[0.0015071617,0.0048913183,0.0017233416,0.000060947674,0.00023185197,0.0016926301,0.00004800647,0.019953448,0.9285138,0.00090475025,0.04041264,0.0000600591],"about_ca_topic_score_codex":0.00062421616,"about_ca_topic_score_gemma":0.0019884866,"teacher_disagreement_score":0.0016443634,"about_ca_system_score_codex":0.0006163136,"about_ca_system_score_gemma":0.00039740378,"threshold_uncertainty_score":0.0055009723},"labels":[],"label_agreement":null},{"id":"W2098159853","doi":"10.1016/j.bmcl.2009.07.015","title":"Thiazole analog as stearoyl-CoA desaturase 1 inhibitor","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Thiazole; Chemistry; Amide; Chemical synthesis; Stereochemistry; Biochemistry; Pharmacology; In vitro; Biology","score_opus":0.0047240232044394835,"score_gpt":0.22502148971182206,"score_spread":0.22029746650738258,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2098159853","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95436794,0.025485242,0.002669678,0.0008752469,0.00035612125,0.00011332164,0.0009856139,0.0003750728,0.014771765],"genre_scores_gemma":[0.98223853,0.0070052356,0.0009016251,0.0001675757,0.000043458513,0.000029270977,0.00078143494,0.00000984913,0.00882301],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999609,0.0000051588045,0.000002272721,0.0000069320727,0.000006631229,0.00001802541],"domain_scores_gemma":[0.9999827,0.0000023557448,0.0000027902847,0.0000019325323,0.0000028799866,0.0000073707756],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000054034732,0.00019367246,0.00031364214,0.00020560395,0.00023274538,0.00014333379,0.000340151,0.0002861679,0.0029961246],"category_scores_gemma":[0.000058189464,0.000079553894,0.00013197312,0.00023676817,0.00011205519,0.00012045193,0.00010174348,0.0004188342,0.0005077646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003909231,0.00029558968,0.0005170537,0.0003546433,0.000050258743,0.0014615615,0.00006679284,0.0007798173,0.9471783,0.001204365,0.0053263986,0.03885595],"study_design_scores_gemma":[0.0013107575,0.0064577204,0.006092133,0.00003545798,0.00018174415,0.0035616336,0.00006119471,0.0026139952,0.9209276,0.000220266,0.058492646,0.000044857425],"about_ca_topic_score_codex":0.0020263456,"about_ca_topic_score_gemma":0.0047299494,"teacher_disagreement_score":0.0029961246,"about_ca_system_score_codex":0.0003239611,"about_ca_system_score_gemma":0.00021920096,"threshold_uncertainty_score":0.010022998},"labels":[],"label_agreement":null},{"id":"W2098556835","doi":"10.1016/j.bmcl.2007.03.028","title":"β-Substituted cyclohexanecarboxamide cathepsin K inhibitors: Modification of the 1,2-disubstituted aromatic core","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Thiazole; Potency; Linker; Stereochemistry; Pyridine; Pyrazole; Benzothiazole; Medicinal chemistry; In vitro; Biochemistry","score_opus":0.028133519305925902,"score_gpt":0.28646137357835133,"score_spread":0.25832785427242544,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2098556835","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98439354,0.0020316818,0.0040485137,0.00019000356,0.00012957536,0.00006464854,0.00019621408,0.00013070751,0.008815164],"genre_scores_gemma":[0.9946878,0.0011166559,0.0012886339,0.00008728809,0.000024620995,0.000021947288,0.00010679472,0.000014259054,0.0026519233],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992704,0.00001323596,0.0000054032594,0.000012472026,0.000012035996,0.00002986698],"domain_scores_gemma":[0.9999565,0.0000060131706,0.00001417358,0.000005771812,0.000004224681,0.000013396643],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010144895,0.0003269051,0.00019925208,0.00010754136,0.00013329895,0.00016580637,0.00030359882,0.00020139226,0.002037563],"category_scores_gemma":[0.00010531211,0.00010836107,0.00015014074,0.00010569199,0.00014912117,0.00021110738,0.00012834063,0.00032300322,0.00042831764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006843442,0.00008039166,0.00013637196,0.000091348666,0.000014396025,0.00037034423,0.000039974013,0.0006544163,0.9883867,0.00089698605,0.00023738419,0.008407404],"study_design_scores_gemma":[0.00012515915,0.0014331023,0.0015454922,0.000011993474,0.000031883443,0.0006487474,0.000019358564,0.0009688577,0.9882124,0.00008918367,0.0068935687,0.000020235098],"about_ca_topic_score_codex":0.0008804095,"about_ca_topic_score_gemma":0.0015276747,"teacher_disagreement_score":0.002037563,"about_ca_system_score_codex":0.00025134248,"about_ca_system_score_gemma":0.0002444397,"threshold_uncertainty_score":0.0068163276},"labels":[],"label_agreement":null},{"id":"W2098848709","doi":"10.1016/j.bmcl.2007.12.010","title":"Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Cleavage (geology); Guanidine; Small molecule; Amyloid precursor protein; Amyloid precursor protein secretase; Stereochemistry; Amyloid (mycology); Biochemistry; Alzheimer's disease; Disease","score_opus":0.013421247185462282,"score_gpt":0.2671871869297971,"score_spread":0.2537659397443348,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2098848709","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900656,0.002557388,0.0038429243,0.00017402259,0.00005598689,0.000111620495,0.00013001077,0.00008818328,0.0029742767],"genre_scores_gemma":[0.9928329,0.0017004864,0.004282377,0.00010080694,0.000020329653,0.000032653148,0.00011758256,0.00002059035,0.00089232996],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982256,0.000050211547,0.000018204071,0.000028764745,0.000033778244,0.00004656346],"domain_scores_gemma":[0.9998554,0.00003765877,0.00004404247,0.0000126258055,0.000014685395,0.000035511806],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038910907,0.0006023705,0.0005497335,0.0001871637,0.0002111281,0.00031767925,0.0005322782,0.000401027,0.0015294002],"category_scores_gemma":[0.00038568638,0.00024786094,0.0002950111,0.00021301162,0.00021661964,0.000372807,0.00026143622,0.0007206045,0.00032940664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003029674,0.00037308404,0.0003753667,0.00017272145,0.00005896548,0.00066646474,0.000092568385,0.0045851315,0.96872455,0.0009244188,0.0002644268,0.02073268],"study_design_scores_gemma":[0.0014319748,0.0073109427,0.0025080154,0.000048685444,0.00019381651,0.0012391955,0.000072775445,0.009964092,0.96989036,0.0003725593,0.006901895,0.00006573817],"about_ca_topic_score_codex":0.00076051435,"about_ca_topic_score_gemma":0.001774713,"teacher_disagreement_score":0.0015294002,"about_ca_system_score_codex":0.0003196802,"about_ca_system_score_gemma":0.00028443115,"threshold_uncertainty_score":0.0051163435},"labels":[],"label_agreement":null},{"id":"W2100268373","doi":"10.1016/s0960-894x(03)00394-9","title":"Constrained phytoestrogens and analogues as ERβ selective ligands","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Phytoestrogens; Estrogen receptor; Apigenin; Luciferase; Metallothionein; Selectivity; Binding selectivity; Structure–activity relationship; Estrogen receptor beta; Potency; Biochemistry; Receptor; Estrogen; In vitro; Internal medicine; Endocrinology; Gene; Transfection; Flavonoid; Biology","score_opus":0.0034205721529087674,"score_gpt":0.20714517621489656,"score_spread":0.20372460406198778,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2100268373","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91993827,0.026860343,0.022597458,0.0006396753,0.00028399174,0.00018051993,0.0014710155,0.00034821208,0.02768045],"genre_scores_gemma":[0.9611011,0.012639327,0.0061782836,0.00034752564,0.000035628324,0.00009921875,0.0008456777,0.000047134992,0.018706098],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994326,0.000014125543,0.0000035074181,0.000012019238,0.000011224894,0.00001596376],"domain_scores_gemma":[0.99996936,0.000008354955,0.000005462367,0.0000054259717,0.0000047064937,0.000006679255],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345888,0.00020559004,0.0002369066,0.00014147231,0.00013677278,0.0003824053,0.00035519796,0.00025706354,0.0044834656],"category_scores_gemma":[0.00012459834,0.00017889675,0.0001013456,0.00023394659,0.00018682137,0.0002872334,0.00030713135,0.0003513123,0.00095713616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001806413,0.0001741294,0.00025251444,0.00049474783,0.000045229757,0.00038140654,0.00014861926,0.0066532153,0.92892593,0.011765427,0.0024553852,0.046896968],"study_design_scores_gemma":[0.00022606661,0.0015071956,0.00068783714,0.000043108386,0.00005452935,0.00034177987,0.00009844373,0.002417034,0.89943516,0.001700789,0.093446516,0.00004158499],"about_ca_topic_score_codex":0.00048655327,"about_ca_topic_score_gemma":0.0013394215,"teacher_disagreement_score":0.0044834656,"about_ca_system_score_codex":0.00026663876,"about_ca_system_score_gemma":0.000114797986,"threshold_uncertainty_score":0.014998674},"labels":[],"label_agreement":null},{"id":"W2101449587","doi":"10.1016/j.bmcl.2005.05.027","title":"Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Max-Planck-Gesellschaft","keywords":"Chemistry; Microsome; ATP synthase; Potency; Enzyme; Prostaglandin; Enzyme inhibitor; Thromboxane-A synthase; Biochemistry; Prostaglandin H2; Stereochemistry; Indole test; In vitro; Selectivity; Prostaglandin E2; Cyclooxygenase; Arachidonic acid; Internal medicine","score_opus":0.007296075274614038,"score_gpt":0.2132772759817257,"score_spread":0.20598120070711165,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2101449587","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9822525,0.00542658,0.00587729,0.0003382847,0.00022764139,0.00012600754,0.00056373415,0.0001996786,0.0049884743],"genre_scores_gemma":[0.9905026,0.003369859,0.002164198,0.000076992386,0.000035448073,0.000067169836,0.00060546666,0.000014228502,0.0031641365],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999161,0.000013371149,0.0000088687,0.000009748334,0.000018990086,0.000033004715],"domain_scores_gemma":[0.9999602,0.000006903554,0.000011941349,0.00000433643,0.0000050527233,0.000011589438],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013444129,0.00034564693,0.00024470224,0.00018750614,0.00011580951,0.00017358336,0.00020095702,0.00017340369,0.0015213259],"category_scores_gemma":[0.00013428397,0.0001398901,0.00026080263,0.00012275872,0.00014749519,0.00015501237,0.00017878268,0.0007088002,0.00045855212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001912147,0.0002778325,0.00028875296,0.00022122236,0.000049164628,0.00016897915,0.000031067266,0.00067758205,0.98142886,0.0007413814,0.00054093805,0.013662059],"study_design_scores_gemma":[0.00035423366,0.002138925,0.0018316512,0.000013568394,0.00006680285,0.00042732857,0.000017106971,0.0011669229,0.98547727,0.00013052959,0.008364589,0.000011139205],"about_ca_topic_score_codex":0.0003057314,"about_ca_topic_score_gemma":0.0005318837,"teacher_disagreement_score":0.0015213259,"about_ca_system_score_codex":0.00017872368,"about_ca_system_score_gemma":0.00027061405,"threshold_uncertainty_score":0.0050893426},"labels":[],"label_agreement":null},{"id":"W2102530798","doi":"10.1016/j.bmcl.2007.05.094","title":"Cytostatic activity of novel 4′-aminochalcone-based imides","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Acadia University","funders":"","keywords":"Chemistry; Quantitative structure–activity relationship; In vivo; In vitro; Pyrrole; Toxicity; Pharmacology; Stereochemistry; Cytotoxicity; IC50; Cytotoxic T cell; Combinatorial chemistry; Biochemistry; Organic chemistry; Biology","score_opus":0.027963589872383954,"score_gpt":0.24930175457516413,"score_spread":0.22133816470278017,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102530798","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9886264,0.0039645894,0.0012554105,0.00009471037,0.000046384834,0.00004672042,0.0002698809,0.000073974385,0.0056218007],"genre_scores_gemma":[0.99516344,0.0015356439,0.00078118296,0.000039324143,0.000017564736,0.000031914587,0.00029577437,0.000007295014,0.0021277985],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999423,0.000012721132,0.000006569332,0.0000080696045,0.000010997448,0.000019427514],"domain_scores_gemma":[0.99995077,0.000010080637,0.000010358463,0.00000469643,0.000008489914,0.000015591442],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012248733,0.00032516787,0.00024019381,0.00022566387,0.00014292012,0.00017845702,0.0003561879,0.00022020939,0.0016210998],"category_scores_gemma":[0.00011842831,0.00008184359,0.000116177725,0.00015441667,0.00013126215,0.00019608988,0.00014004277,0.00031146038,0.0003270881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00077128765,0.00008500856,0.0001756361,0.00013506075,0.00001353215,0.00019894853,0.000040105104,0.0005828507,0.9896309,0.000397419,0.00018481929,0.0077844085],"study_design_scores_gemma":[0.00006648872,0.0008479195,0.0006020221,0.000006742433,0.000019853203,0.00020433984,0.000011055496,0.0006026706,0.99461824,0.00003369841,0.0029804104,0.0000066640846],"about_ca_topic_score_codex":0.00045430745,"about_ca_topic_score_gemma":0.00068849354,"teacher_disagreement_score":0.0016210998,"about_ca_system_score_codex":0.00028712387,"about_ca_system_score_gemma":0.00017128795,"threshold_uncertainty_score":0.0054231286},"labels":[],"label_agreement":null},{"id":"W2102774552","doi":"10.1016/s0960-894x(02)00537-1","title":"Isomeric acetoxy analogues of rofecoxib: A novel class of highly potent and selective cyclooxygenase-2 inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Rofecoxib; Chemistry; Moiety; Cyclooxygenase; Substituent; Stereochemistry; Isozyme; Enzyme inhibitor; Chemical synthesis; Structure–activity relationship; Pharmacology; Enzyme; In vitro; Biochemistry","score_opus":0.009844208613744087,"score_gpt":0.2029564815966787,"score_spread":0.19311227298293462,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102774552","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96535456,0.0145186195,0.0053480337,0.0007072231,0.00027556514,0.00016517889,0.00069173553,0.00019435155,0.012744551],"genre_scores_gemma":[0.9787295,0.008632658,0.0037083246,0.00030575244,0.00014880438,0.00005975269,0.0008890113,0.000020157157,0.007506243],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992263,0.000012803914,0.0000058422797,0.000009478056,0.00001770104,0.000031635638],"domain_scores_gemma":[0.99996233,0.0000034852446,0.000010499725,0.00000445989,0.0000049862397,0.000014267836],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610713,0.00036995148,0.00035922963,0.00018771256,0.00014247328,0.00021793951,0.00034293934,0.00022902252,0.0026601371],"category_scores_gemma":[0.00011111745,0.00012335104,0.00012457125,0.00016457449,0.00015115576,0.0002671553,0.00017769905,0.00059731514,0.0005913433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0027776898,0.00036116413,0.00046687128,0.00018323681,0.000035822573,0.00091062346,0.000078745994,0.0010572997,0.92878604,0.002271498,0.0019895271,0.06108131],"study_design_scores_gemma":[0.0018797816,0.012274989,0.0066525145,0.000042101256,0.000170915,0.004976961,0.00011339761,0.0025344065,0.8829581,0.00056850194,0.087762855,0.00006544712],"about_ca_topic_score_codex":0.00043967864,"about_ca_topic_score_gemma":0.0010528304,"teacher_disagreement_score":0.0026601371,"about_ca_system_score_codex":0.0001695596,"about_ca_system_score_gemma":0.00017985386,"threshold_uncertainty_score":0.008899033},"labels":[],"label_agreement":null},{"id":"W2102910526","doi":"10.1016/j.bmcl.2004.07.070","title":"Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Quinazolinone; Efflux; Chemistry; Fluconazole; Candida albicans; Drug discovery; Pharmacology; Combinatorial chemistry; Antifungal; Biochemistry; Microbiology; Medicine; Biology","score_opus":0.013468604905204355,"score_gpt":0.26686510935465263,"score_spread":0.2533965044494483,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102910526","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9432247,0.03527076,0.01084924,0.0010313452,0.00018751355,0.00063088356,0.0019082357,0.00039313544,0.0065041385],"genre_scores_gemma":[0.972635,0.014424095,0.0069015273,0.0003074103,0.000069430775,0.00014517474,0.001640287,0.000026783013,0.0038502421],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992454,0.000014620145,0.0000070761807,0.00001470198,0.000020675814,0.000018478508],"domain_scores_gemma":[0.9999447,0.000009738244,0.000013421678,0.0000066797907,0.00001116641,0.000014193756],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018496542,0.00045258584,0.00037367735,0.00026908377,0.00015142163,0.00021807877,0.00047367183,0.00033342018,0.0015501782],"category_scores_gemma":[0.00025345368,0.00022357088,0.00024366318,0.00018343794,0.00021013299,0.00025771483,0.00018380384,0.0004500015,0.00034286236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006960308,0.00027729856,0.00038852703,0.00038109947,0.00004533026,0.00035357915,0.000060801474,0.0009887984,0.9530024,0.0003512427,0.0011699753,0.04228486],"study_design_scores_gemma":[0.001259854,0.007885329,0.009711481,0.000063966014,0.000208222,0.002830209,0.000033495584,0.0020010658,0.9538093,0.00021408456,0.021918017,0.00006499155],"about_ca_topic_score_codex":0.0005524455,"about_ca_topic_score_gemma":0.0013586275,"teacher_disagreement_score":0.0015501782,"about_ca_system_score_codex":0.0002319145,"about_ca_system_score_gemma":0.00022275359,"threshold_uncertainty_score":0.0051858425},"labels":[],"label_agreement":null},{"id":"W2102922603","doi":"10.1016/j.bmcl.2007.04.069","title":"Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Biodistribution; Chemistry; Diazepine; Ligand (biochemistry); Chemical synthesis; Stereochemistry; Receptor; In vitro; Organic chemistry; Biochemistry; Ring (chemistry)","score_opus":0.02815642246672834,"score_gpt":0.29917471438705934,"score_spread":0.271018291920331,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102922603","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9321012,0.002722318,0.04246211,0.000401211,0.00015438463,0.0002755715,0.0018783842,0.0006800462,0.019324759],"genre_scores_gemma":[0.97240305,0.0015424838,0.011540381,0.000060378214,0.00002041465,0.00006096666,0.0009049743,0.00009571646,0.013371663],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999294,0.000009319169,0.0000051612697,0.00001677993,0.000012757708,0.000026639575],"domain_scores_gemma":[0.9999207,0.000012577045,0.000017707034,0.0000134522625,0.000011629691,0.000023833078],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015345686,0.0003172637,0.00022711893,0.00026227182,0.00016144586,0.00026496945,0.00045296372,0.00027630353,0.0014562925],"category_scores_gemma":[0.00015791993,0.00018560162,0.0001364898,0.0001616976,0.0001771629,0.00018680713,0.0001477053,0.0003838141,0.0008802082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021733485,0.000033443524,0.000059022183,0.000028065078,0.0000054511083,0.00008084389,0.00002273896,0.00020155875,0.9966642,0.00023967466,0.00006638656,0.0023811972],"study_design_scores_gemma":[0.000036998514,0.00024932314,0.00058271,0.000002548628,0.000021108313,0.00013673941,0.000011025334,0.00056966936,0.99465936,0.000038832648,0.0036868367,0.000004769749],"about_ca_topic_score_codex":0.0023239872,"about_ca_topic_score_gemma":0.0023430241,"teacher_disagreement_score":0.0023239872,"about_ca_system_score_codex":0.0003824559,"about_ca_system_score_gemma":0.0004394622,"threshold_uncertainty_score":0.0048717856},"labels":[],"label_agreement":null},{"id":"W2103152475","doi":"10.1016/s0960-894x(03)00668-1","title":"Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Spermidine; Putrescine; Chemistry; Polyamine; Spermine; Ether; Stereochemistry; Biochemistry; Organic chemistry; Enzyme","score_opus":0.003837530066591345,"score_gpt":0.19450154829746397,"score_spread":0.19066401823087262,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2103152475","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99761474,0.0004859417,0.0006222005,0.000026297068,0.000016367976,0.000012595169,0.00008229225,0.000022400895,0.0011170437],"genre_scores_gemma":[0.9970687,0.00032478909,0.00073966116,0.000021426717,0.0000053842546,0.000007750627,0.000212984,0.000026815498,0.0015925006],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988294,0.000031984513,0.000011551679,0.000022103237,0.00002011774,0.00003126231],"domain_scores_gemma":[0.99981695,0.00004653186,0.000034714816,0.000016439846,0.0000238068,0.000061620245],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016609786,0.00035438652,0.00030787836,0.00008482908,0.00012980573,0.00033374617,0.00034955086,0.0002740371,0.0019382344],"category_scores_gemma":[0.0002410406,0.00017881692,0.00015330431,0.00016934631,0.00020570004,0.00028070432,0.00017367145,0.00057035376,0.00034705782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00078022236,0.00003556229,0.00006990864,0.00003124791,0.000012153351,0.000048055612,0.000025049321,0.00014784113,0.99788123,0.00012166265,0.000025326863,0.00082170236],"study_design_scores_gemma":[0.000018485476,0.00019685431,0.00020420922,0.0000021474093,0.000007683908,0.000024766185,0.000008516706,0.000514941,0.9986945,0.000009800051,0.0003152823,0.0000028400325],"about_ca_topic_score_codex":0.0012395934,"about_ca_topic_score_gemma":0.0011285304,"teacher_disagreement_score":0.0019382344,"about_ca_system_score_codex":0.0002659076,"about_ca_system_score_gemma":0.00023215033,"threshold_uncertainty_score":0.0064840317},"labels":[],"label_agreement":null},{"id":"W2103304897","doi":"10.1016/j.bmcl.2007.10.069","title":"Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tetrapyrrole; Chemistry; Pheophorbide A; In vitro; MTT assay; Hematoporphyrin; Cytotoxicity; Semisynthesis; Cell culture; Porphyrin; Biochemistry; Biological activity; Stereochemistry; Combinatorial chemistry; Photodynamic therapy; Organic chemistry; Enzyme","score_opus":0.031873207483956494,"score_gpt":0.3636143414946665,"score_spread":0.33174113401071,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2103304897","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99370205,0.0017931528,0.0030185352,0.000036997637,0.000018666617,0.000055461118,0.00015031848,0.00003471707,0.0011900871],"genre_scores_gemma":[0.9941857,0.0010644338,0.002930338,0.000017030112,0.00000835433,0.000030040603,0.00029524157,0.000010728871,0.0014582332],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991524,0.000022650047,0.000011919571,0.000012439463,0.000018808643,0.000018887733],"domain_scores_gemma":[0.9999113,0.000030966938,0.000018646402,0.000013792016,0.000012593394,0.000012644901],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025442042,0.00026044232,0.00019171316,0.00018468715,0.00011948219,0.00011657368,0.00019179213,0.00020073852,0.0009518621],"category_scores_gemma":[0.00022219676,0.00013946735,0.00020826778,0.00016823628,0.00012637753,0.00020226979,0.000088011126,0.00022645576,0.00019043419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002673305,0.00008155421,0.00005070369,0.00003443374,0.0000047584876,0.000049320708,0.000012821356,0.0002048754,0.9976332,0.00003975985,0.00001407416,0.0016071742],"study_design_scores_gemma":[0.000016548815,0.000622345,0.00038787565,0.0000016527341,0.000010484655,0.000050479342,0.000003490373,0.00018649778,0.99831945,0.0000064163755,0.0003932141,0.0000015083042],"about_ca_topic_score_codex":0.00036559836,"about_ca_topic_score_gemma":0.00045924375,"teacher_disagreement_score":0.0009518621,"about_ca_system_score_codex":0.000119231576,"about_ca_system_score_gemma":0.0000977455,"threshold_uncertainty_score":0.003184259},"labels":[],"label_agreement":null},{"id":"W2103513032","doi":"10.1016/j.bmcl.2015.11.008","title":"Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"University of Calgary; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Carvedilol; Ryanodine receptor 2; Chemistry; Ryanodine receptor; Calcium; Pharmacology; Calcium channel; Hydroxylation; HEK 293 cells; Heart failure; Biochemistry; Internal medicine; Receptor; Enzyme; Biology; Medicine","score_opus":0.01743716834939601,"score_gpt":0.255939658917967,"score_spread":0.23850249056857098,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2103513032","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9964257,0.0009765911,0.0013055035,0.00012251009,0.00003646753,0.000029246312,0.00017934153,0.00006453495,0.00086010783],"genre_scores_gemma":[0.9974221,0.00055978773,0.0008545069,0.000040595925,0.000022861444,0.000020078453,0.00028775664,0.000011994447,0.00078032835],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998982,0.000022055103,0.000010456294,0.000011360456,0.00001503382,0.00004286357],"domain_scores_gemma":[0.9998216,0.00005530154,0.000030272906,0.000029122974,0.000020456831,0.000043167864],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018722816,0.00034636966,0.0003491389,0.00023784563,0.00018208096,0.00023625177,0.00039764674,0.00032690386,0.0016714098],"category_scores_gemma":[0.0002962637,0.00017786687,0.00032401484,0.00011026533,0.00026247895,0.00033355405,0.0001999656,0.0007425574,0.00027340165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0049039023,0.00016346872,0.00022160407,0.00006887152,0.000024097979,0.00022512882,0.000062467036,0.00012701983,0.98873466,0.00028053028,0.00009105939,0.005097183],"study_design_scores_gemma":[0.00018500217,0.0011282805,0.0008120765,0.0000040125283,0.000030020039,0.00016891338,0.000024632516,0.0005794607,0.9962243,0.000063123676,0.000772661,0.0000074546415],"about_ca_topic_score_codex":0.00041795996,"about_ca_topic_score_gemma":0.00053868425,"teacher_disagreement_score":0.0016714098,"about_ca_system_score_codex":0.00017187087,"about_ca_system_score_gemma":0.00031382043,"threshold_uncertainty_score":0.0055913925},"labels":[],"label_agreement":null},{"id":"W2103999294","doi":"10.1016/j.bmcl.2004.12.082","title":"Novel jadomycins: incorporation of non-natural and natural amino acids","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Amino acid; Electrospray ionization; Mass spectrometry; Streptomyces; Stereochemistry; Biochemistry; Chromatography; Bacteria","score_opus":0.007864671344428859,"score_gpt":0.21997198324932454,"score_spread":0.21210731190489568,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2103999294","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9816466,0.003886173,0.010096673,0.0001436667,0.0001541858,0.000070084825,0.0005245688,0.000171896,0.003306102],"genre_scores_gemma":[0.9836712,0.0013299204,0.011568022,0.000070221664,0.000012503826,0.000032540425,0.00044222156,0.000039314902,0.0028340558],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999299,0.000011927296,0.000008765196,0.000015628573,0.0000113365395,0.00002235059],"domain_scores_gemma":[0.99987733,0.000014958624,0.000020912443,0.000016923725,0.000011815474,0.000058099373],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013602531,0.00028109775,0.0002923813,0.00014123441,0.0001707415,0.00063891587,0.0003084966,0.00035441475,0.00065783825],"category_scores_gemma":[0.00015612804,0.00012680715,0.00016382984,0.00015531968,0.00021561242,0.0004753631,0.00030472977,0.0005805843,0.00036678114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039890595,0.00003786548,0.00015849929,0.00006150332,0.0000053088356,0.00010181443,0.000015399117,0.00010487469,0.99487793,0.00047160411,0.000050577353,0.0037156476],"study_design_scores_gemma":[0.00002243223,0.0001563993,0.00031874707,0.0000039606302,0.000008208019,0.0001763165,0.000010943162,0.00024704545,0.99482226,0.000066254586,0.004161875,0.0000055547757],"about_ca_topic_score_codex":0.00016501588,"about_ca_topic_score_gemma":0.00036831424,"teacher_disagreement_score":0.00065783825,"about_ca_system_score_codex":0.00026369674,"about_ca_system_score_gemma":0.00021374159,"threshold_uncertainty_score":0.002200663},"labels":[],"label_agreement":null},{"id":"W2104577976","doi":"10.1016/s0960-894x(03)00388-3","title":"Structure–activity study of novel tricyclic benzazepine arginine vasopressin antagonists","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Electrolyte and hormonal disorders","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Tricyclic; Benzazepine; Chemistry; Vasopressin; Arginine; Pharmacology; Vasopressin receptor; Receptor; Stereochemistry; Biochemistry; Endocrinology; Amino acid; Biology","score_opus":0.016537277191502248,"score_gpt":0.26442117574778073,"score_spread":0.2478838985562785,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2104577976","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97717685,0.013771886,0.0015005468,0.0002578577,0.000097852324,0.00013592564,0.00058734306,0.000060216174,0.0064114644],"genre_scores_gemma":[0.986472,0.007732814,0.0014129027,0.000123439,0.000061591985,0.00003665507,0.0007399128,0.000010216868,0.003410466],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998727,0.000026574453,0.000009745783,0.000015070242,0.000033626846,0.000042223517],"domain_scores_gemma":[0.99990416,0.000018901543,0.000028553708,0.0000065995673,0.00001595411,0.000025725934],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016711759,0.00025757556,0.0004373509,0.00024224877,0.00018395972,0.00019706287,0.0004602811,0.00018112254,0.0026707707],"category_scores_gemma":[0.00024210931,0.00014078613,0.00022561653,0.00021194779,0.00018547972,0.00014324894,0.00013915054,0.00041816296,0.00039900382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.004936984,0.0008788217,0.0009555089,0.0006992236,0.00018280426,0.00075594906,0.0001539745,0.0044686915,0.9414465,0.0009714334,0.0014028212,0.043147393],"study_design_scores_gemma":[0.0044542183,0.059867337,0.01542224,0.0001151504,0.00069196726,0.0042559556,0.0001566108,0.013237333,0.86688465,0.00042734176,0.034354083,0.00013314145],"about_ca_topic_score_codex":0.0012439182,"about_ca_topic_score_gemma":0.0033596472,"teacher_disagreement_score":0.0026707707,"about_ca_system_score_codex":0.00029416857,"about_ca_system_score_gemma":0.00019882432,"threshold_uncertainty_score":0.008934617},"labels":[],"label_agreement":null},{"id":"W2105602596","doi":"10.1016/j.bmcl.2011.04.073","title":"New light labile linker for solid phase synthesis of 2′-O-acetalester oligonucleotides and applications to siRNA prodrug development","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Linker; Oligonucleotide; Prodrug; Chemistry; Solid-phase synthesis; Nucleic acid; Oligonucleotide synthesis; Combinatorial chemistry; Chemical synthesis; Biochemistry; Stereochemistry; In vitro; DNA; Peptide","score_opus":0.016082125813336193,"score_gpt":0.28558692796852647,"score_spread":0.2695048021551903,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2105602596","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.79805,0.003041227,0.18653323,0.00049946667,0.00016815469,0.00031396296,0.0007316291,0.0013205179,0.0093419105],"genre_scores_gemma":[0.8774166,0.0018485741,0.10531717,0.00039037754,0.00005896625,0.00033059425,0.0011371338,0.00017628918,0.013324283],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983287,0.00002855761,0.0000147254395,0.000042798314,0.000042760334,0.00003818061],"domain_scores_gemma":[0.99977726,0.000045699675,0.00009291614,0.000025957122,0.000025907659,0.000032260163],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030773456,0.0005655211,0.00020853424,0.0002117674,0.00020864145,0.00018655277,0.00042802544,0.0004934086,0.0024503283],"category_scores_gemma":[0.00023285439,0.00030136187,0.00028053255,0.00018932835,0.00022910573,0.0005316987,0.000307134,0.00075429206,0.0011035537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006127001,0.00002385653,0.000039291343,0.00005255196,0.0000030294443,0.0000822183,0.000023189454,0.00014270302,0.99581945,0.00040656107,0.000089823065,0.0032560066],"study_design_scores_gemma":[0.0000138596,0.00016645665,0.00017705148,0.0000044524486,0.000005310736,0.00015044057,0.0000060966445,0.000376036,0.9952075,0.00005102877,0.0038333274,0.000008337864],"about_ca_topic_score_codex":0.00025074245,"about_ca_topic_score_gemma":0.0007305194,"teacher_disagreement_score":0.0024503283,"about_ca_system_score_codex":0.00026430108,"about_ca_system_score_gemma":0.00036344316,"threshold_uncertainty_score":0.008197129},"labels":[],"label_agreement":null},{"id":"W2105946373","doi":"10.1016/j.bmcl.2006.04.011","title":"Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Chemistry; Sulfonamide; Protease; Lysine; Protease inhibitor (pharmacology); Enzyme inhibitor; Potency; Human immunodeficiency virus (HIV); Amino acid; Stereochemistry; Biochemistry; In vitro; Enzyme; Virology","score_opus":0.007701417357923256,"score_gpt":0.21794682161367196,"score_spread":0.2102454042557487,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2105946373","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95797634,0.020918133,0.005932415,0.00032087587,0.00022844128,0.00010717861,0.0001712386,0.00019625263,0.01414919],"genre_scores_gemma":[0.9832114,0.009508113,0.0025329532,0.00015384183,0.000055360244,0.000034796398,0.00012479075,0.0000125624265,0.004366368],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999212,0.000022459817,0.00000603427,0.000009455182,0.000016150761,0.000024746241],"domain_scores_gemma":[0.9999553,0.000008836813,0.000009418956,0.0000035061225,0.000007029677,0.000015960557],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025615317,0.00037758372,0.00025692192,0.00016574125,0.00013903872,0.00026918692,0.0002986649,0.00025836262,0.0009340392],"category_scores_gemma":[0.00015354408,0.00012911936,0.00014431104,0.00011253288,0.0001963902,0.00027859668,0.00018841421,0.00031980488,0.00038093605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018545387,0.0001992969,0.000595789,0.00028384483,0.000031585027,0.00078444864,0.00012136032,0.0018064468,0.92894065,0.0037160332,0.00084673485,0.060819324],"study_design_scores_gemma":[0.00047463868,0.00591007,0.0024527884,0.0000371298,0.00009259106,0.0014553815,0.00006481391,0.003923752,0.9476042,0.000546374,0.037408948,0.000029366041],"about_ca_topic_score_codex":0.00041701415,"about_ca_topic_score_gemma":0.00093450834,"teacher_disagreement_score":0.0009340392,"about_ca_system_score_codex":0.00031176457,"about_ca_system_score_gemma":0.00019108718,"threshold_uncertainty_score":0.0031246543},"labels":[],"label_agreement":null},{"id":"W2106066891","doi":"10.1016/j.bmcl.2007.10.050","title":"N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada); Nicolet Chartrand Knoll (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; Acetylation; HDAC1; In vivo; In vitro; Recombinant DNA; Histone; Biochemistry; IC50; Cancer research; Stereochemistry; Gene; Biology","score_opus":0.010200838211317795,"score_gpt":0.28799909576569765,"score_spread":0.27779825755437987,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2106066891","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8745932,0.043242805,0.03091106,0.0008946519,0.00078217173,0.00026239682,0.0005863847,0.00093888905,0.04778847],"genre_scores_gemma":[0.9627092,0.017149892,0.0066332533,0.0003032508,0.00015671887,0.00014944952,0.00041254834,0.000056311987,0.012429228],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988747,0.000021518092,0.00000615279,0.00001631244,0.000024694906,0.000043780932],"domain_scores_gemma":[0.9999577,0.0000069709386,0.0000126242085,0.0000039093243,0.000007085241,0.000011737893],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023958199,0.00039328134,0.00038026823,0.0002552981,0.00017486967,0.00022465509,0.0005487114,0.00029754004,0.0022136213],"category_scores_gemma":[0.00011941134,0.00017984718,0.00020169896,0.0001707635,0.00015325988,0.00028048144,0.00023441168,0.00048561385,0.0008201727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00056822324,0.00019718624,0.0002132423,0.00027973746,0.000032304444,0.000268529,0.0000700137,0.0010648519,0.96137947,0.0033129381,0.0012959184,0.031317644],"study_design_scores_gemma":[0.00041540852,0.0027792032,0.0028906239,0.000046739657,0.000098281154,0.00063035503,0.000040595452,0.0035737036,0.94346505,0.0004892375,0.045528915,0.00004192393],"about_ca_topic_score_codex":0.00065962656,"about_ca_topic_score_gemma":0.0019100623,"teacher_disagreement_score":0.0022136213,"about_ca_system_score_codex":0.00032593732,"about_ca_system_score_gemma":0.00019196705,"threshold_uncertainty_score":0.0074053407},"labels":[],"label_agreement":null},{"id":"W2106187115","doi":"10.1016/s0960-894x(00)00133-5","title":"5-Thienyltryptamine derivatives as serotonin 5-HT 1B/1D receptor agonists: potential treatments for migraine","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xerox (Canada)","funders":"","keywords":"Tetrahydrofuran; Triethylamine; Reflux; Chemistry; Reagent; Tryptamine; Toluene; Medicinal chemistry; Stereochemistry; Internal medicine; Organic chemistry; Medicine; Biochemistry","score_opus":0.00973917434797173,"score_gpt":0.2612966723584764,"score_spread":0.2515574980105047,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2106187115","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.52520716,0.45455036,0.0009823765,0.0018711785,0.00036042585,0.00010396899,0.00040751125,0.000033908556,0.016483009],"genre_scores_gemma":[0.734566,0.25342003,0.0012370751,0.0009263594,0.00045591206,0.00005039049,0.0003615758,0.000005722209,0.008976988],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995756,0.000017956978,0.0000038070482,0.0000045892875,0.0000073632973,0.000008704187],"domain_scores_gemma":[0.99994564,0.000022231045,0.000011978872,0.0000034335333,0.0000051036063,0.000011698168],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002900129,0.00013559678,0.00024847634,0.00022780513,0.00014049686,0.00023869597,0.00020229121,0.00033468293,0.0038175646],"category_scores_gemma":[0.00023339162,0.00008237893,0.00012734844,0.00026050291,0.00018219749,0.00026841526,0.0001175133,0.0003599648,0.00045577012],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.017820911,0.0012782175,0.007129226,0.0037964834,0.00019291112,0.0031869172,0.0006026642,0.00080941565,0.33058143,0.0072057615,0.006342834,0.6210533],"study_design_scores_gemma":[0.009292128,0.090338774,0.14927703,0.0011871365,0.001920013,0.01590699,0.001434034,0.0022654403,0.20683567,0.005358834,0.51602685,0.0001571304],"about_ca_topic_score_codex":0.00072201574,"about_ca_topic_score_gemma":0.003140345,"teacher_disagreement_score":0.0038175646,"about_ca_system_score_codex":0.00015729072,"about_ca_system_score_gemma":0.00015003426,"threshold_uncertainty_score":0.01277101},"labels":[],"label_agreement":null},{"id":"W2106679464","doi":"10.1016/j.bmcl.2006.01.085","title":"Substituted coumarins as potent 5-lipoxygenase inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Coumarin; Lipoxygenase; Arachidonate 5-lipoxygenase; Enzyme; Leukotriene; Enzyme inhibitor; Structure–activity relationship; Chemical synthesis; Biosynthesis; Pharmacology; Biochemistry; Stereochemistry; In vitro; Asthma; Arachidonic acid; Organic chemistry; Immunology","score_opus":0.005103645432798604,"score_gpt":0.21548094191472472,"score_spread":0.21037729648192613,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2106679464","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94229954,0.030727874,0.008015929,0.00075325347,0.0004540144,0.0001258772,0.00081740716,0.00045743785,0.01634861],"genre_scores_gemma":[0.98398596,0.009131444,0.0014523539,0.00014524764,0.00006410934,0.000024910441,0.00035344224,0.000021328804,0.0048211287],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999336,0.000015226958,0.000004202043,0.000008596727,0.000011243685,0.000027186594],"domain_scores_gemma":[0.99996567,0.000007935293,0.0000074339296,0.000005121143,0.0000037145073,0.000010157267],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015464182,0.00035762344,0.0002654724,0.0003051487,0.0002094445,0.00023415704,0.00036248137,0.0002979968,0.003266991],"category_scores_gemma":[0.00011760096,0.00016627612,0.00015059511,0.0002955139,0.00021882591,0.00028667582,0.00027776626,0.0006492225,0.00055541587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0025558437,0.00033864204,0.00040654393,0.0005367035,0.00006438013,0.0009900866,0.00018355135,0.0053443653,0.91777754,0.008243577,0.0026957886,0.060862996],"study_design_scores_gemma":[0.0006583975,0.0053561144,0.003082062,0.00006007892,0.00012442294,0.0009376404,0.000071923845,0.0042512924,0.9278889,0.0011757987,0.05633728,0.00005610834],"about_ca_topic_score_codex":0.0004338438,"about_ca_topic_score_gemma":0.0010778736,"teacher_disagreement_score":0.003266991,"about_ca_system_score_codex":0.00021409914,"about_ca_system_score_gemma":0.00012118718,"threshold_uncertainty_score":0.010929167},"labels":[],"label_agreement":null},{"id":"W2108232940","doi":"10.1016/j.bmcl.2005.02.056","title":"A general carbometalation, three component coupling strategy for the synthesis of α,β-unsaturated γ-sultines including thio-rofecoxib, a selective COX-2 inhibitor","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Organic and Inorganic Chemical Reactions","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alphora Research (Canada); University of Ottawa","funders":"","keywords":"Chemistry; Rofecoxib; Thio-; Enzyme inhibitor; Chemical synthesis; COX-2 inhibitor; Stereochemistry; Combinatorial chemistry; Enzyme; Organic chemistry; Biochemistry; Cyclooxygenase; In vitro","score_opus":0.025350880662698062,"score_gpt":0.25819265377710543,"score_spread":0.23284177311440737,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2108232940","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86953664,0.005872706,0.092283286,0.0007677219,0.00047075155,0.00055140845,0.0011313041,0.0008766978,0.028509438],"genre_scores_gemma":[0.97170424,0.0027358006,0.016872229,0.00018044304,0.00003567884,0.00012833113,0.0004775245,0.00004197781,0.007823802],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991846,0.000010453775,0.00000766122,0.000018751962,0.000016570562,0.00002815771],"domain_scores_gemma":[0.9999721,0.0000023888153,0.0000072764246,0.000004623457,0.000004997466,0.000008653834],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014682123,0.00067385583,0.00025065785,0.00027696,0.00026963462,0.00015980568,0.00039936745,0.0003230608,0.0014464587],"category_scores_gemma":[0.00007266506,0.00021044376,0.00029019822,0.00025851463,0.00016956365,0.00032032668,0.00024088872,0.0005036485,0.00059159525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023943903,0.00012561266,0.00016921482,0.00024153685,0.00003241654,0.00063015084,0.00011936763,0.0006471587,0.9733348,0.002135516,0.0007379026,0.021586832],"study_design_scores_gemma":[0.00008496126,0.0010486324,0.0010297057,0.000012032018,0.0000635319,0.00090748334,0.000038694532,0.000987218,0.97977656,0.0003791593,0.015640402,0.00003166498],"about_ca_topic_score_codex":0.0010617989,"about_ca_topic_score_gemma":0.00260965,"teacher_disagreement_score":0.0014464587,"about_ca_system_score_codex":0.00033563926,"about_ca_system_score_gemma":0.0006138734,"threshold_uncertainty_score":0.004838884},"labels":[],"label_agreement":null},{"id":"W2108885056","doi":"10.1016/j.bmcl.2004.04.005","title":"Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Benzimidazole; Potency; Chemical synthesis; Stereochemistry; Pharmacology; Receptor; Structure–activity relationship; In vitro; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.010801183147248377,"score_gpt":0.22425027718755647,"score_spread":0.2134490940403081,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2108885056","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8213194,0.1587037,0.0045128944,0.001628395,0.0006220561,0.00025773872,0.00046829437,0.00038402385,0.01210349],"genre_scores_gemma":[0.9291862,0.06026353,0.0028367396,0.0005415665,0.00030020706,0.00007305001,0.00061006594,0.00002443329,0.0061642714],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988115,0.00001933856,0.000008419299,0.0000112198295,0.000030033725,0.00004977281],"domain_scores_gemma":[0.9999622,0.0000069946773,0.000008194477,0.0000022038714,0.000006463864,0.000013921381],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023886056,0.00033265437,0.0005281095,0.00030811972,0.0002048119,0.000349342,0.00048466702,0.00034975406,0.0019639193],"category_scores_gemma":[0.00017438146,0.00016942466,0.00020613396,0.00026653276,0.00022104368,0.00023337225,0.00020605985,0.0009891066,0.00046825796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003258674,0.0005806963,0.0009959382,0.00076298695,0.000071818344,0.0012377257,0.00016309491,0.0007531805,0.7676469,0.0022622321,0.0037214162,0.2185453],"study_design_scores_gemma":[0.012155607,0.029960211,0.038903147,0.00031324156,0.000958286,0.010671536,0.00029111825,0.0077355723,0.6557459,0.0015692698,0.24148996,0.00020615221],"about_ca_topic_score_codex":0.0013172288,"about_ca_topic_score_gemma":0.0054259524,"teacher_disagreement_score":0.0019639193,"about_ca_system_score_codex":0.00038083238,"about_ca_system_score_gemma":0.00027597893,"threshold_uncertainty_score":0.006569922},"labels":[],"label_agreement":null},{"id":"W2109201085","doi":"10.1016/j.bmcl.2011.11.114","title":"Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Antimycobacterial; Chemistry; Pyrimidine; Nucleoside; Mycobacterium tuberculosis; Mycobacterium bovis; Alkyl; Stereochemistry; Tuberculosis; Organic chemistry; Medicine","score_opus":0.05187140831263822,"score_gpt":0.2835093076139923,"score_spread":0.23163789930135406,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2109201085","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99150145,0.0044802865,0.0003291256,0.00006462216,0.00003642572,0.000024708796,0.00029200097,0.000028091541,0.0032432643],"genre_scores_gemma":[0.9962115,0.0017190342,0.000579174,0.00006488693,0.000016754455,0.00001642969,0.0005167286,0.000006258838,0.00086923415],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980944,0.00007123739,0.000020724206,0.000020935007,0.000030359332,0.000047322144],"domain_scores_gemma":[0.999833,0.000055635486,0.000028511378,0.000018002766,0.000024895355,0.000039961225],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002712984,0.00021977228,0.00041474486,0.00020158265,0.00015275509,0.0001968529,0.00026242816,0.00028663917,0.002216418],"category_scores_gemma":[0.00035791486,0.00014331425,0.00018171692,0.00022176585,0.00014569882,0.0001363059,0.00017560787,0.00048495422,0.00035320432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0020791767,0.00017121878,0.0012327929,0.00021174416,0.00003607622,0.00034674586,0.00010022712,0.0013223162,0.9774734,0.0002914897,0.00026391825,0.016470928],"study_design_scores_gemma":[0.0004199677,0.010459751,0.010456595,0.00007907487,0.00013028305,0.0013978932,0.000096003794,0.0016369177,0.96474284,0.00013207686,0.01041876,0.000029768966],"about_ca_topic_score_codex":0.0010149626,"about_ca_topic_score_gemma":0.0023381594,"teacher_disagreement_score":0.002216418,"about_ca_system_score_codex":0.00019480941,"about_ca_system_score_gemma":0.0002829897,"threshold_uncertainty_score":0.0074146986},"labels":[],"label_agreement":null},{"id":"W2109537387","doi":"10.1016/j.bmcl.2003.08.083","title":"(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Histone deacetylase; Acetylation; Histone; Amino acid; In vitro; Histone deacetylase inhibitor; Recombinant DNA; Stereochemistry; Biochemistry; Gene","score_opus":0.010171625611111198,"score_gpt":0.26493804011923106,"score_spread":0.2547664145081199,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2109537387","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9303614,0.019368026,0.014175529,0.00047222318,0.00047689307,0.00017527185,0.0004394738,0.00024000175,0.03429122],"genre_scores_gemma":[0.97634363,0.010708147,0.0045921705,0.00020266784,0.00010744368,0.00008322882,0.0002395497,0.00002940166,0.0076937866],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993825,0.000013600213,0.0000048597917,0.000008134709,0.000012256048,0.000022880875],"domain_scores_gemma":[0.9999416,0.000010820211,0.000014747434,0.000005013845,0.000007717076,0.000020059493],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021126441,0.00037656375,0.0002247442,0.00020457926,0.00011987568,0.00017067706,0.0003226336,0.00029308628,0.0021060389],"category_scores_gemma":[0.0001217472,0.00016632084,0.00017345183,0.0001592532,0.0001623172,0.0003828364,0.00023114472,0.0004930374,0.0007220013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007497879,0.00017644138,0.00019053134,0.0003322073,0.000025452,0.00063998986,0.00012612199,0.0020149017,0.96666247,0.00347305,0.00053897913,0.02506997],"study_design_scores_gemma":[0.00035343764,0.005543309,0.0025046174,0.000072195435,0.000072607094,0.00079336076,0.00007725109,0.0030645994,0.9494675,0.0008590489,0.037153535,0.00003853832],"about_ca_topic_score_codex":0.00022745287,"about_ca_topic_score_gemma":0.00044516538,"teacher_disagreement_score":0.0021060389,"about_ca_system_score_codex":0.00016889737,"about_ca_system_score_gemma":0.00014260785,"threshold_uncertainty_score":0.007045388},"labels":[],"label_agreement":null},{"id":"W2110263699","doi":"10.1016/j.bmcl.2005.12.020","title":"Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Sulfonamide; Chemistry; Potency; In vitro; Pharmacology; Ether; Stereochemistry; Enzyme; Arthritis; Biochemistry; Organic chemistry; Internal medicine; Medicine","score_opus":0.00513546104195048,"score_gpt":0.19988024598194415,"score_spread":0.19474478493999367,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2110263699","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6437176,0.25205037,0.04005888,0.0027184184,0.0022529,0.0007133513,0.001490285,0.001419345,0.055578884],"genre_scores_gemma":[0.8312197,0.123227574,0.0066928538,0.001457947,0.0010406623,0.00045258112,0.0017460153,0.00009418448,0.0340686],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999248,0.000012592926,0.000008226029,0.000007930913,0.000020642463,0.000025804213],"domain_scores_gemma":[0.99996305,0.0000075431894,0.000010634954,0.000004522037,0.000006291383,0.000007943009],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028433165,0.0006322384,0.00039805254,0.000498219,0.00014264265,0.00021990326,0.00045537273,0.00037233302,0.001764668],"category_scores_gemma":[0.00015707115,0.0002145301,0.0003060986,0.00022821731,0.00021780844,0.00037601602,0.000206967,0.00047516014,0.00085940614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014330795,0.00042364153,0.00029110975,0.0006121398,0.00007256875,0.00067565404,0.0000982627,0.002578183,0.7809258,0.0036181577,0.009052545,0.20021875],"study_design_scores_gemma":[0.0007642624,0.0078080874,0.0048169745,0.00011670521,0.0002093009,0.003104667,0.000042714462,0.0029522674,0.7912215,0.0012593019,0.18764327,0.00006090097],"about_ca_topic_score_codex":0.0004867173,"about_ca_topic_score_gemma":0.0007433978,"teacher_disagreement_score":0.001764668,"about_ca_system_score_codex":0.00031366938,"about_ca_system_score_gemma":0.00018014322,"threshold_uncertainty_score":0.005903363},"labels":[],"label_agreement":null},{"id":"W2112138262","doi":"10.1016/s0960-894x(03)00514-6","title":"Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Sulfonamide; In vivo; Stereochemistry; Potency; In vitro; Enzyme; Selectivity; Structure–activity relationship; Matrix metalloproteinase; Hydroxamic acid; Chemical synthesis; Arthritis; Enzyme inhibitor; Pharmacology; Biochemistry; Internal medicine","score_opus":0.01164426207536908,"score_gpt":0.24079747351080039,"score_spread":0.2291532114354313,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2112138262","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8921819,0.06547112,0.01282828,0.0007919126,0.00039556526,0.00024387625,0.00180112,0.00037556305,0.025910651],"genre_scores_gemma":[0.95302606,0.032942016,0.0033674403,0.0004621932,0.00013825695,0.00012515872,0.0019857546,0.000015021976,0.007938173],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999571,0.000010654616,0.0000049427185,0.000003553302,0.000010960838,0.000012850769],"domain_scores_gemma":[0.99996877,0.00000810706,0.000008822928,0.000003336116,0.0000041486333,0.000006826985],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379812,0.00040108626,0.00023577722,0.00015496596,0.00007823105,0.00010963344,0.00024688095,0.00012094186,0.0015062555],"category_scores_gemma":[0.00013548913,0.00009149749,0.00013800409,0.00013101942,0.00013061664,0.00016688542,0.0001112171,0.0003043503,0.00047996064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011121547,0.00016947047,0.0002880171,0.00051282306,0.00004295338,0.0004402488,0.000099081735,0.0022590226,0.9156916,0.0017106332,0.0027899807,0.07488405],"study_design_scores_gemma":[0.00061307056,0.00962911,0.006628747,0.0001363461,0.00021566515,0.0027200629,0.000095265925,0.0025205866,0.83317,0.0009876017,0.14323944,0.000044089502],"about_ca_topic_score_codex":0.00039182336,"about_ca_topic_score_gemma":0.0009286914,"teacher_disagreement_score":0.0015062555,"about_ca_system_score_codex":0.00017090619,"about_ca_system_score_gemma":0.00011483039,"threshold_uncertainty_score":0.0050389767},"labels":[],"label_agreement":null},{"id":"W2112330923","doi":"10.1016/j.bmcl.2004.04.058","title":"Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Moiety; Enzyme inhibitor; Chemical synthesis; Stereochemistry; Potency; Structure–activity relationship; Plasminogen activator inhibitor-1; Plasminogen activator; Combinatorial chemistry; Biochemistry; Enzyme; In vitro; Internal medicine","score_opus":0.00789015035881669,"score_gpt":0.20839088958486424,"score_spread":0.20050073922604755,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2112330923","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8794547,0.038063798,0.04678303,0.0013558485,0.0011533783,0.0007995327,0.0018298919,0.0006199593,0.029939923],"genre_scores_gemma":[0.9488595,0.017190622,0.01891437,0.0003162451,0.00007054875,0.0002247751,0.0009985269,0.000042072825,0.013383295],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998766,0.000017726696,0.000012816812,0.000020082805,0.000019609732,0.000052958192],"domain_scores_gemma":[0.9999223,0.000009507909,0.000017118808,0.0000057808247,0.000014163285,0.000031029715],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030505474,0.00051392,0.00039300064,0.00029769124,0.0002188979,0.00055287586,0.0007137838,0.00028405502,0.0025238143],"category_scores_gemma":[0.00021140628,0.0002768982,0.00020106742,0.0003333719,0.00026285183,0.00029691405,0.00030214986,0.00060835504,0.0008274769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013061204,0.0004225323,0.00063951185,0.0011978,0.000052205865,0.0014115284,0.00043286209,0.007239652,0.9107011,0.011802708,0.0030130043,0.06178098],"study_design_scores_gemma":[0.0008043428,0.0031243844,0.0012644993,0.00007629915,0.00009629142,0.0006965928,0.00009360625,0.004656893,0.91001517,0.0010061767,0.07809263,0.00007297692],"about_ca_topic_score_codex":0.0008911186,"about_ca_topic_score_gemma":0.0018878155,"teacher_disagreement_score":0.0025238143,"about_ca_system_score_codex":0.000698246,"about_ca_system_score_gemma":0.0006589461,"threshold_uncertainty_score":0.008442998},"labels":[],"label_agreement":null},{"id":"W2112354998","doi":"10.1016/s0960-894x(00)00465-0","title":"Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Serine protease; Protease; Tetrapeptide; Peptide; Stereochemistry; Serine; Proteases; Biochemistry; NS3; Enzyme inhibitor; Enzyme","score_opus":0.010609007565208243,"score_gpt":0.23679020753283553,"score_spread":0.22618119996762728,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2112354998","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8618095,0.042974535,0.06310407,0.001397416,0.0005256858,0.0007774654,0.00087914144,0.0005462556,0.0279859],"genre_scores_gemma":[0.93048006,0.027832413,0.020144628,0.00085147296,0.00016703337,0.00022965753,0.0010467664,0.000094410134,0.01915352],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986696,0.000022430644,0.000009626006,0.00002241965,0.00003720655,0.000041365398],"domain_scores_gemma":[0.9999306,0.0000151790955,0.000012007584,0.0000056685744,0.00001296419,0.000023437759],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034096054,0.0005589086,0.0003493848,0.00024395772,0.00014595733,0.00042619283,0.00037302368,0.0003906478,0.0019155171],"category_scores_gemma":[0.00019578163,0.00026507408,0.00020240946,0.0001638386,0.0002456368,0.00043894723,0.00034128316,0.00090825604,0.00094363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004874539,0.00016841499,0.00009998824,0.0002900524,0.000020003714,0.00019767128,0.00008852741,0.0015040685,0.9672608,0.0014322941,0.001342249,0.027108576],"study_design_scores_gemma":[0.000283482,0.0013865896,0.00051193114,0.000023974002,0.00004604771,0.00057495537,0.00002585147,0.002162352,0.9694179,0.00040737985,0.025135428,0.000024072011],"about_ca_topic_score_codex":0.0003288908,"about_ca_topic_score_gemma":0.0007258699,"teacher_disagreement_score":0.0019155171,"about_ca_system_score_codex":0.0003350076,"about_ca_system_score_gemma":0.00022093685,"threshold_uncertainty_score":0.0064080358},"labels":[],"label_agreement":null},{"id":"W2112849289","doi":"10.1016/j.bmcl.2004.06.076","title":"Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Stereocenter; Antibiotics; Antibacterial agent; Antibacterial activity; Stereochemistry; Beta-lactam; Microbiology; Bacteria; Organic chemistry; Biochemistry; Enantioselective synthesis; Biology","score_opus":0.014731036730667741,"score_gpt":0.25339249234123956,"score_spread":0.2386614556105718,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2112849289","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93012226,0.028236281,0.020977253,0.0008039375,0.0002478318,0.00019712423,0.0007718896,0.0002973335,0.018346045],"genre_scores_gemma":[0.964887,0.016166583,0.011983139,0.00025854088,0.000056377132,0.00005602831,0.0006386785,0.000028914186,0.00592478],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994063,0.000013099788,0.0000042102392,0.0000092834725,0.000019479705,0.000013420791],"domain_scores_gemma":[0.9999474,0.000008142498,0.000010692226,0.0000064571877,0.0000136791,0.000013490214],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002556413,0.0002458683,0.00023353453,0.000278285,0.00011004129,0.0002247247,0.00043278307,0.00025661883,0.0010824316],"category_scores_gemma":[0.00018959807,0.00011740667,0.00017266374,0.00015607191,0.00021182497,0.00030359157,0.00017756745,0.00036661976,0.00033989412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004262048,0.00012958348,0.00063683174,0.00027487896,0.000013965243,0.00046495287,0.000060774877,0.000772656,0.9299724,0.004886243,0.00063088717,0.061730683],"study_design_scores_gemma":[0.00016506908,0.0014737134,0.0017648801,0.00004061869,0.00005104145,0.0008113688,0.000031767642,0.0012732429,0.9671697,0.000778663,0.026424251,0.000015559846],"about_ca_topic_score_codex":0.0004405256,"about_ca_topic_score_gemma":0.000938605,"teacher_disagreement_score":0.0010824316,"about_ca_system_score_codex":0.0003609529,"about_ca_system_score_gemma":0.00024455064,"threshold_uncertainty_score":0.0036210418},"labels":[],"label_agreement":null},{"id":"W2116247393","doi":"10.1016/j.bmcl.2014.09.010","title":"Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis of Indole Derivatives","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre for Drug Research and Development; University of British Columbia","funders":"Fondation pour la Recherche Médicale; Auckland Medical Research Foundation","keywords":"Staphylococcus aureus; Chemistry; Gene isoform; Pyruvate kinase; Methicillin-resistant Staphylococcus aureus; Kinase; Biochemistry; Enzyme; Bacteria; Gene; Glycolysis; Biology","score_opus":0.016017562747723688,"score_gpt":0.2392510923679979,"score_spread":0.2232335296202742,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2116247393","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9554876,0.0067370636,0.025123201,0.00075215567,0.00016384147,0.00020921454,0.0005295628,0.0002604949,0.010736791],"genre_scores_gemma":[0.97757065,0.002486508,0.011781734,0.00022777758,0.000025636953,0.000085220585,0.00042976238,0.000025903533,0.00736676],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999405,0.000011057879,0.0000031404124,0.000012120545,0.00001540573,0.000017781946],"domain_scores_gemma":[0.9999584,0.000007144869,0.0000115242265,0.0000037733312,0.0000065783715,0.00001257608],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013846162,0.00026077675,0.00014337343,0.00014082533,0.00010798662,0.00018936428,0.00018365373,0.000305149,0.00089798594],"category_scores_gemma":[0.00010063326,0.00014124949,0.0001333423,0.00006449348,0.00013205809,0.00012121746,0.0001239356,0.0003821755,0.00026834416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007654234,0.000027130518,0.00005458566,0.000031245298,0.000002873242,0.00007579039,0.000010900631,0.00012350886,0.99611026,0.00028532924,0.000093735485,0.0031080802],"study_design_scores_gemma":[0.00003410066,0.0003539078,0.00061974593,0.0000044167737,0.0000070166093,0.0003038947,0.000006257818,0.0004902147,0.99343276,0.00004198014,0.0047022905,0.0000035054736],"about_ca_topic_score_codex":0.00032300755,"about_ca_topic_score_gemma":0.0009785678,"teacher_disagreement_score":0.00089798594,"about_ca_system_score_codex":0.00025409705,"about_ca_system_score_gemma":0.00024502768,"threshold_uncertainty_score":0.0030040145},"labels":[],"label_agreement":null},{"id":"W2116428224","doi":"10.1016/j.bmcl.2005.12.071","title":"Identification of a potent and selective non-basic cathepsin K inhibitor","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Isostere; Cathepsin; Enzyme inhibitor; Pharmacokinetics; Pharmacology; Cathepsin D; Stereochemistry; Biochemistry; In vitro; Enzyme; Biology","score_opus":0.006104866527583561,"score_gpt":0.237253668909904,"score_spread":0.23114880238232044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2116428224","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9536473,0.014302355,0.02034904,0.000832577,0.00021225086,0.00045613345,0.0013675432,0.0004011988,0.008431708],"genre_scores_gemma":[0.97511715,0.005713838,0.0073934663,0.00030115483,0.000058466383,0.000118300355,0.002623955,0.00003125662,0.008642276],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987423,0.000013228587,0.000011809918,0.00002257711,0.000035535955,0.00004263424],"domain_scores_gemma":[0.9999293,0.000011624934,0.000011591545,0.000007882119,0.000015310794,0.000024304116],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021949396,0.0005240753,0.00050649565,0.00025642585,0.00020547991,0.00049509143,0.00046047114,0.00039368178,0.0014435318],"category_scores_gemma":[0.00017895612,0.00022840952,0.00028778487,0.0001752663,0.00017867581,0.00027785235,0.00028407451,0.00074684416,0.0008338494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000525744,0.00022665338,0.00033676924,0.00010459782,0.000026234757,0.0002523678,0.000028398312,0.00027769807,0.984018,0.0003242195,0.0007182506,0.013161017],"study_design_scores_gemma":[0.00025476297,0.0015092624,0.0018494118,0.000009021181,0.00006301173,0.0016990054,0.00001785683,0.0010410795,0.9805489,0.00009105468,0.012902544,0.000014028823],"about_ca_topic_score_codex":0.0005097946,"about_ca_topic_score_gemma":0.0011558671,"teacher_disagreement_score":0.0014435318,"about_ca_system_score_codex":0.00048702632,"about_ca_system_score_gemma":0.0005085968,"threshold_uncertainty_score":0.0048291087},"labels":[],"label_agreement":null},{"id":"W2116788622","doi":"10.1016/j.bmcl.2003.08.055","title":"2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Anxiolytic; Trifluoromethyl; Receptor; Stereochemistry; Chemical synthesis; Antagonist; Pharmacology; In vitro; Biochemistry; Organic chemistry","score_opus":0.05269348782834631,"score_gpt":0.3096372956092988,"score_spread":0.2569438077809525,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2116788622","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95019346,0.0264375,0.013392713,0.000409841,0.00019580494,0.00034446048,0.0008463538,0.00036900485,0.007810831],"genre_scores_gemma":[0.9700431,0.01623063,0.006223771,0.00019224168,0.000082695755,0.00014446348,0.000703425,0.000040020837,0.0063396427],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998913,0.000031406787,0.0000056846243,0.000013048297,0.00001759013,0.00004088022],"domain_scores_gemma":[0.99992,0.000022142243,0.000016771051,0.000009622919,0.000013870092,0.00001758421],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025915552,0.00038356008,0.0005030888,0.00025004463,0.0003563914,0.00020528093,0.0006211545,0.0003563501,0.0021299294],"category_scores_gemma":[0.0002355615,0.00024373336,0.00023380856,0.00032654658,0.0002301685,0.00032639812,0.00022448334,0.00055835774,0.0005793102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012500096,0.0002221486,0.00027844208,0.00030074167,0.000031333395,0.00033916594,0.00014207642,0.00096175395,0.97230023,0.0009845735,0.0007886984,0.022400688],"study_design_scores_gemma":[0.00071092264,0.010930415,0.006928477,0.00005534396,0.00017684327,0.0014189262,0.000118542885,0.0033967576,0.943302,0.0003354971,0.032540992,0.00008525891],"about_ca_topic_score_codex":0.0023045638,"about_ca_topic_score_gemma":0.0055197054,"teacher_disagreement_score":0.0023045638,"about_ca_system_score_codex":0.00031811022,"about_ca_system_score_gemma":0.0002935004,"threshold_uncertainty_score":0.0071253777},"labels":[],"label_agreement":null},{"id":"W2116861142","doi":"10.1016/j.bmcl.2004.06.025","title":"Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Varicella zoster virus; Chemistry; Virus; Virology; Herpesviridae; Thiourea; Viral disease; Biology; Organic chemistry","score_opus":0.011694185982569926,"score_gpt":0.23729362432905535,"score_spread":0.2255994383464854,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2116861142","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.22621009,0.7249602,0.008157641,0.0018457556,0.002271545,0.00045959587,0.0006844433,0.00051529414,0.034895465],"genre_scores_gemma":[0.40230992,0.54165226,0.0038942818,0.0022284081,0.0019018803,0.0003448098,0.0016682224,0.000073076924,0.04592718],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999336,0.00001079856,0.0000047744707,0.0000059899667,0.00001838902,0.000026434669],"domain_scores_gemma":[0.9999598,0.000009544025,0.000009739794,0.0000022225859,0.000008378198,0.000010344085],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024414505,0.000694985,0.00042137582,0.0008860248,0.00021946256,0.00026253329,0.0004402387,0.00039439116,0.002383704],"category_scores_gemma":[0.00013433698,0.0002246298,0.000510078,0.0003592363,0.00013370592,0.0002530415,0.00016702361,0.0005793424,0.00085292704],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002321056,0.0015695574,0.0007130906,0.0019461905,0.00024489648,0.00090485293,0.00020881735,0.002885454,0.32131964,0.002792033,0.02857253,0.63652194],"study_design_scores_gemma":[0.002465159,0.01756909,0.019453665,0.0004382803,0.00088153733,0.0052820765,0.00009635751,0.00425899,0.47645968,0.0017222767,0.47125825,0.000114780174],"about_ca_topic_score_codex":0.0012359658,"about_ca_topic_score_gemma":0.002381614,"teacher_disagreement_score":0.002383704,"about_ca_system_score_codex":0.00034125763,"about_ca_system_score_gemma":0.00020744176,"threshold_uncertainty_score":0.007974327},"labels":[],"label_agreement":null},{"id":"W2118407518","doi":"10.1016/j.bmcl.2008.09.018","title":"Synthesis and evaluation of novel 4-amino-4,6-androstadiene-3,17-dione: An analog of formestane","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Aromatase; In vitro; Cell culture; Cancer; Breast cancer; Cancer cell lines; Chemical synthesis; Stereochemistry; Cancer research; Pharmacology; Biochemistry; Cancer cell; Internal medicine; Biology; Medicine; Genetics","score_opus":0.1496066646559138,"score_gpt":0.40126308749235623,"score_spread":0.2516564228364424,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2118407518","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9647534,0.008876047,0.010503779,0.00043845747,0.0003002208,0.0004584925,0.0014318472,0.00015060102,0.013087307],"genre_scores_gemma":[0.9748526,0.004235109,0.0075320383,0.00014118564,0.000036758684,0.000073933494,0.000966152,0.000016699594,0.012145553],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991703,0.000014314346,0.000009746541,0.000018085453,0.000018715204,0.000022061051],"domain_scores_gemma":[0.9999243,0.0000057998486,0.000013078416,0.000008351679,0.000014038133,0.000034364],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015456884,0.0003405915,0.00023144156,0.00029826284,0.00021201652,0.00022650218,0.00033636,0.00024520647,0.0026855601],"category_scores_gemma":[0.000108683635,0.00012684318,0.00021853816,0.00018891359,0.00018914863,0.00023577968,0.00020172223,0.0003478979,0.0005861111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006177884,0.00030622538,0.00031024398,0.00018602546,0.000026780039,0.0006164022,0.00006576373,0.0010030707,0.97800326,0.0006548708,0.0002773913,0.017932171],"study_design_scores_gemma":[0.00020085025,0.0038302755,0.0015192198,0.000013695354,0.00006528841,0.0009685396,0.00004954193,0.00067479035,0.9685883,0.0001278951,0.023942536,0.000019170391],"about_ca_topic_score_codex":0.0007538573,"about_ca_topic_score_gemma":0.00186727,"teacher_disagreement_score":0.0026855601,"about_ca_system_score_codex":0.00028834955,"about_ca_system_score_gemma":0.00048865064,"threshold_uncertainty_score":0.008984029},"labels":[],"label_agreement":null},{"id":"W2118477747","doi":"10.1016/s0960-894x(03)00154-9","title":"3-Amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Reactions of Organic Compounds","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McMaster University","keywords":"Acetamide; Chemistry; Substituent; Discovery and development of direct thrombin inhibitors; Stereochemistry; Bicyclic molecule; Sulfonyl; Hydrogen bond; Thrombin; Carboxamide; Molecule; Organic chemistry; Platelet","score_opus":0.00713737525057037,"score_gpt":0.19663673919127528,"score_spread":0.1894993639407049,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2118477747","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92328465,0.03944369,0.007711819,0.0008006937,0.0003336701,0.00017907402,0.0003191554,0.00026979973,0.027657464],"genre_scores_gemma":[0.97286236,0.015411467,0.0029794578,0.00024021276,0.00012961497,0.00009402651,0.00029627202,0.000014033732,0.007972549],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998945,0.000028544311,0.000008184473,0.0000102140175,0.000024786936,0.000033747383],"domain_scores_gemma":[0.99995327,0.000013315972,0.0000144772785,0.000004387684,0.000005140638,0.000009507932],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448033,0.00031071654,0.00025703388,0.00023788055,0.00021597226,0.00019692762,0.0003074454,0.00030266997,0.0015519431],"category_scores_gemma":[0.00017258718,0.0001455207,0.00014458156,0.00018266455,0.00020179494,0.00019473794,0.0002389111,0.00042400358,0.0003047841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021877303,0.00039864317,0.0007796715,0.0005355001,0.00005149022,0.002321516,0.00019768512,0.0049566072,0.9112742,0.008296221,0.0023347277,0.06666595],"study_design_scores_gemma":[0.0009343504,0.009066176,0.005929998,0.00006723013,0.00010112959,0.005218082,0.00009545874,0.0047326493,0.8872856,0.0013096962,0.08520967,0.00004988977],"about_ca_topic_score_codex":0.0008205274,"about_ca_topic_score_gemma":0.0016517603,"teacher_disagreement_score":0.0015519431,"about_ca_system_score_codex":0.00039346586,"about_ca_system_score_gemma":0.00021589939,"threshold_uncertainty_score":0.005191803},"labels":[],"label_agreement":null},{"id":"W2119499868","doi":"10.1016/j.bmcl.2003.10.023","title":"Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Benzimidazole; NS5B; Chemistry; Hepatitis C virus; Polymerase; Drug discovery; Combinatorial chemistry; Nucleoside; High-throughput screening; RNA polymerase; Enzyme; Virology; Biochemistry; Virus; Hepacivirus; RNA; Biology; Organic chemistry","score_opus":0.009352868706358144,"score_gpt":0.2421191275471439,"score_spread":0.23276625884078575,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119499868","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92658186,0.050984006,0.007428888,0.0007498733,0.00015073305,0.00022756298,0.0006771373,0.00016117438,0.013038708],"genre_scores_gemma":[0.963015,0.024810055,0.0044358354,0.00027311125,0.00005459434,0.00005846018,0.0013935881,0.000022808825,0.0059363893],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998863,0.000027044895,0.000007255387,0.000010007708,0.000032858574,0.000036462156],"domain_scores_gemma":[0.9999242,0.000020022942,0.00001343504,0.000006780289,0.000015763802,0.00001984565],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025999104,0.00036970607,0.00030132625,0.00019876366,0.00018322415,0.000290909,0.00036996912,0.00023621079,0.001640761],"category_scores_gemma":[0.00027626823,0.00013998162,0.00021891814,0.00016486018,0.00016473462,0.00018059638,0.00018229707,0.0006322767,0.00037849497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014292973,0.00044159847,0.0009497296,0.0005396188,0.00003966503,0.0006224642,0.00018933053,0.002120435,0.93102545,0.001717472,0.0014921556,0.05943296],"study_design_scores_gemma":[0.0008138022,0.009145252,0.009301091,0.0001305504,0.00012829996,0.0016684543,0.00011098947,0.005456957,0.9292182,0.0004587637,0.043503836,0.00006381253],"about_ca_topic_score_codex":0.0027007358,"about_ca_topic_score_gemma":0.010448818,"teacher_disagreement_score":0.0027007358,"about_ca_system_score_codex":0.00055470614,"about_ca_system_score_gemma":0.00032034406,"threshold_uncertainty_score":0.005488932},"labels":[],"label_agreement":null},{"id":"W2119764915","doi":"10.1016/s0960-894x(02)00577-2","title":"Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Proto-oncogene tyrosine-protein kinase Src; Kinase; Stereochemistry; Ring (chemistry); Enzyme inhibitor; Chemical synthesis; Structure–activity relationship; Enzyme; Biochemistry; In vitro; Organic chemistry","score_opus":0.011373044553238754,"score_gpt":0.21611638907531106,"score_spread":0.2047433445220723,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119764915","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94014275,0.019841176,0.012979642,0.00057059445,0.00033168454,0.00018596387,0.00046967427,0.00057746354,0.024901034],"genre_scores_gemma":[0.9827728,0.0077122157,0.0024048765,0.00012522664,0.000047100195,0.00007050087,0.0002610171,0.00003480802,0.0065713725],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998598,0.00003340752,0.0000075692524,0.000018469877,0.000032313856,0.000048398397],"domain_scores_gemma":[0.9999379,0.000014481337,0.000015478528,0.0000071626723,0.000011390774,0.000013506176],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003174858,0.0003882554,0.00036678708,0.00028112077,0.00020015138,0.00024444645,0.00075739936,0.00037003492,0.0023984872],"category_scores_gemma":[0.00014442681,0.00015351026,0.0001991932,0.00019162359,0.0002164099,0.00035575745,0.0002627812,0.0004946412,0.000693172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089658075,0.00017929116,0.00021166883,0.0003721201,0.000030335792,0.00061739737,0.00011761017,0.0029898537,0.9629046,0.0054759705,0.0014040894,0.02480051],"study_design_scores_gemma":[0.00054065645,0.0037867916,0.0030411596,0.000058846173,0.00007667833,0.0015511186,0.000085687825,0.0058893366,0.94560045,0.00095458265,0.03834032,0.00007441847],"about_ca_topic_score_codex":0.0005376824,"about_ca_topic_score_gemma":0.0010471222,"teacher_disagreement_score":0.0023984872,"about_ca_system_score_codex":0.00038697076,"about_ca_system_score_gemma":0.00019255256,"threshold_uncertainty_score":0.008023739},"labels":[],"label_agreement":null},{"id":"W2119905559","doi":"10.1016/j.bmcl.2011.12.139","title":"Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Centre for Addiction and Mental Health","funders":"Ontario Ministry of Research and Innovation","keywords":"Chemistry; Radiosynthesis; Aryl; Moiety; Urea; Yield (engineering); Medicinal chemistry; Nuclear chemistry; Stereochemistry; Positron emission tomography; Organic chemistry; Nuclear medicine","score_opus":0.019861805807064658,"score_gpt":0.2891356532674828,"score_spread":0.26927384746041816,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119905559","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8807864,0.007919818,0.097773075,0.0004957034,0.00019050254,0.0005508977,0.0007260689,0.00061110524,0.010946463],"genre_scores_gemma":[0.93496555,0.0043840846,0.051253017,0.00017660986,0.00009692671,0.00029624466,0.001012591,0.00015208554,0.0076630055],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996929,0.00009365851,0.000019177229,0.000058404392,0.000056725934,0.000079187404],"domain_scores_gemma":[0.9997733,0.00004820692,0.000057694477,0.00004067335,0.000049515253,0.0000306055],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008949234,0.0007168432,0.00044339043,0.00043552945,0.0003365932,0.00028924053,0.001103672,0.0009444076,0.001501118],"category_scores_gemma":[0.00060136605,0.00039881238,0.00035861798,0.00035605687,0.00039057314,0.00045771693,0.00041126765,0.0010482316,0.001031035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002784599,0.00006150569,0.00009047393,0.00015749046,0.000014173641,0.00020220535,0.00012942229,0.0005218151,0.99212986,0.0007441611,0.00021527626,0.0054552257],"study_design_scores_gemma":[0.00003676582,0.00038147182,0.00026196943,0.000009704037,0.000017053742,0.00024120617,0.000013295104,0.0007118712,0.9951788,0.0000841176,0.003048825,0.000014875615],"about_ca_topic_score_codex":0.0012808278,"about_ca_topic_score_gemma":0.0023197434,"teacher_disagreement_score":0.001501118,"about_ca_system_score_codex":0.00050446263,"about_ca_system_score_gemma":0.00045288083,"threshold_uncertainty_score":0.005021751},"labels":[],"label_agreement":null},{"id":"W2119943615","doi":"10.1016/j.bmcl.2005.08.047","title":"Novel and expanded jadomycins incorporating non-proteogenic amino acids","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Dalhousie University","keywords":"Chemistry; Oxazolone; Metabolite; Stereochemistry; Electrospray ionization; Amino acid; Secondary metabolite; Mass spectrometry; Ring (chemistry); Biochemistry; Organic chemistry; Chromatography","score_opus":0.011132960380474326,"score_gpt":0.22384639493766428,"score_spread":0.21271343455718997,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2119943615","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98559046,0.0022912645,0.008564635,0.0001039695,0.00012361175,0.000062862186,0.00037927364,0.00017999955,0.002703959],"genre_scores_gemma":[0.9852822,0.00078545697,0.010902084,0.000073492214,0.00001788569,0.00003702511,0.00032274897,0.00003417999,0.002544967],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994147,0.000010599399,0.0000060327234,0.000011894786,0.000010903056,0.000019137522],"domain_scores_gemma":[0.9998895,0.000015204041,0.000018314615,0.000015398806,0.000011055829,0.000050499842],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012936362,0.0003070825,0.00026488965,0.00013295519,0.00014030354,0.000406551,0.00027657158,0.0002877846,0.0007653597],"category_scores_gemma":[0.00013268036,0.000119695665,0.00017085698,0.00015558337,0.00018963097,0.00040717854,0.0003467205,0.00065557135,0.0003271801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028006634,0.000033876673,0.00009830128,0.00005087678,0.0000067381598,0.00011328703,0.000021414646,0.00025857697,0.99409217,0.00044564687,0.00007522487,0.0045238496],"study_design_scores_gemma":[0.000043019616,0.0003662862,0.00063539075,0.000006825471,0.000016236307,0.0002208621,0.000017599252,0.0006589902,0.9889348,0.00013594986,0.008952849,0.000011172979],"about_ca_topic_score_codex":0.0001436437,"about_ca_topic_score_gemma":0.0002494686,"teacher_disagreement_score":0.0007653597,"about_ca_system_score_codex":0.00021343936,"about_ca_system_score_gemma":0.00014136349,"threshold_uncertainty_score":0.0025603771},"labels":[],"label_agreement":null},{"id":"W2120198923","doi":"10.1016/j.bmcl.2004.09.088","title":"Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Aminoglycoside; Binding site; Ribosomal RNA; Ribosome; Escherichia coli; A-site; RNA; Ribosomal protein; Biochemistry; Stereochemistry; Antibiotics; Gene","score_opus":0.010061429326719567,"score_gpt":0.22233009939041998,"score_spread":0.2122686700637004,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2120198923","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9811566,0.0013901632,0.010602277,0.0002952222,0.00009549755,0.00006507412,0.00031896148,0.00008287869,0.0059933723],"genre_scores_gemma":[0.9837768,0.00057784974,0.009987382,0.00029031874,0.000047183934,0.000046910598,0.0006376517,0.000020997051,0.004614955],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991477,0.000011389447,0.000002450951,0.000021278489,0.000017288849,0.000032806496],"domain_scores_gemma":[0.999864,0.000041725303,0.000018409919,0.000014207507,0.00001499253,0.00004673106],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010176269,0.0003227822,0.00028694078,0.00029874552,0.00030998985,0.00043403904,0.0005775985,0.000738101,0.0018398997],"category_scores_gemma":[0.00023786491,0.0001419776,0.00034799977,0.00021815137,0.00023061775,0.00019902839,0.00028680952,0.00057446747,0.0006148876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011075676,0.000038830585,0.0002795272,0.000030717205,0.000007306482,0.000359233,0.000019059455,0.00010414642,0.9957683,0.0005803671,0.00007610466,0.0026257285],"study_design_scores_gemma":[0.000036429017,0.00048825832,0.0075790905,0.000010637523,0.0000272924,0.000999148,0.00007992833,0.0029139672,0.9791158,0.0005522386,0.008178609,0.00001864193],"about_ca_topic_score_codex":0.0010215265,"about_ca_topic_score_gemma":0.00080213405,"teacher_disagreement_score":0.0018398997,"about_ca_system_score_codex":0.0004041864,"about_ca_system_score_gemma":0.000257851,"threshold_uncertainty_score":0.0061550736},"labels":[],"label_agreement":null},{"id":"W2121136691","doi":"10.1016/j.bmcl.2013.03.044","title":"Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1","year":2013,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Program for New Century Excellent Talents in University; National Natural Science Foundation of China","keywords":"Chaetomium globosum; Chemistry; Ginkgo biloba; Cytotoxic T cell; Cytotoxicity; Stereochemistry; Fungus; Two-dimensional nuclear magnetic resonance spectroscopy; IC50; Biochemistry; In vitro; Botany; Biology","score_opus":0.00916609497632609,"score_gpt":0.20591089598544,"score_spread":0.1967448010091139,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2121136691","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99177015,0.0015472395,0.0012538683,0.00008222265,0.00002145346,0.000032106007,0.0010839612,0.000067582805,0.0041414513],"genre_scores_gemma":[0.9913707,0.0009840699,0.0008116974,0.000028491573,0.000009536539,0.00001729661,0.002180179,0.000026272059,0.0045717256],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999571,0.0000068994386,0.000003974427,0.0000073839255,0.000012491769,0.000012176171],"domain_scores_gemma":[0.999933,0.000021952372,0.000011124517,0.00001074538,0.0000087348,0.000014523144],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000058357175,0.00028453584,0.00020722291,0.00027790375,0.00020174781,0.00027710554,0.00023410145,0.0002292482,0.0014987128],"category_scores_gemma":[0.00011667666,0.00009595608,0.00014650573,0.00028018962,0.00013926535,0.00017641278,0.00022856225,0.00046271805,0.0005011556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012249127,0.000009199364,0.00010270578,0.00004269101,0.0000032206628,0.00012013846,0.000023262377,0.00015832057,0.9973013,0.000063587824,0.000043194115,0.002009972],"study_design_scores_gemma":[0.000023616427,0.0003019039,0.0039039825,0.000008947898,0.000019365467,0.00039418036,0.000044734887,0.0003886075,0.99121386,0.000097149416,0.003594323,0.000009420109],"about_ca_topic_score_codex":0.0010291052,"about_ca_topic_score_gemma":0.0012731828,"teacher_disagreement_score":0.0014987128,"about_ca_system_score_codex":0.00019249381,"about_ca_system_score_gemma":0.00018143037,"threshold_uncertainty_score":0.0050136447},"labels":[],"label_agreement":null},{"id":"W2123164140","doi":"10.1016/s0960-894x(00)00093-7","title":"Synthesis and pharmacology of new enantiopure Δ3-4-arylkainoids","year":2000,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Enantiopure drug; Affinities; Stereochemistry; Antagonist; Chemical synthesis; Binding affinities; Receptor; In vitro; Biochemistry; Enantioselective synthesis","score_opus":0.026815499078593114,"score_gpt":0.2977158260625578,"score_spread":0.2709003269839647,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2123164140","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9485606,0.0059236763,0.016150521,0.0005533598,0.00031395338,0.00019651798,0.00097252615,0.00037676326,0.026952034],"genre_scores_gemma":[0.9726051,0.0054864786,0.008274757,0.00022764796,0.000053972683,0.00006181999,0.0005725924,0.000042146195,0.012675498],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999167,0.00001051236,0.000010014963,0.000011492181,0.000016069323,0.00003521329],"domain_scores_gemma":[0.9999521,0.0000044645294,0.0000106871585,0.00000849728,0.000008365215,0.000015856793],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017743559,0.00034298087,0.0003084574,0.00029211715,0.00028476003,0.0003177859,0.0006128393,0.00020462881,0.0026486018],"category_scores_gemma":[0.00018284735,0.00016921235,0.00025540133,0.00020637503,0.0002141322,0.00031699098,0.00032716015,0.0005192549,0.0010051625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000715597,0.00018821374,0.00041173972,0.00042048644,0.00006293282,0.0012653427,0.00030004737,0.0018692967,0.9381759,0.007966319,0.0010778602,0.04754627],"study_design_scores_gemma":[0.00019624371,0.0017511916,0.0025966265,0.000048032965,0.00012155962,0.0014181697,0.00016023911,0.002024194,0.9542291,0.0016298098,0.035765897,0.000058846003],"about_ca_topic_score_codex":0.0012755127,"about_ca_topic_score_gemma":0.002902578,"teacher_disagreement_score":0.0026486018,"about_ca_system_score_codex":0.00039808344,"about_ca_system_score_gemma":0.00039243198,"threshold_uncertainty_score":0.008860409},"labels":[],"label_agreement":null},{"id":"W2123391682","doi":"10.1016/j.bmcl.2013.08.025","title":"Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health; Cancer Research UK; Wellcome Trust","keywords":"Bloom syndrome; Helicase; Chemistry; DNA; RecQ helicase; DNA damage; DNA repair; Gene; Biochemistry; Genetics; Biology; RNA","score_opus":0.010975032959181247,"score_gpt":0.23765034144072483,"score_spread":0.22667530848154357,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2123391682","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9677454,0.0097922,0.009593986,0.0005049293,0.00014982157,0.00048117785,0.0016974725,0.0002448964,0.009790076],"genre_scores_gemma":[0.9794222,0.0070639006,0.0050681224,0.00012439236,0.00003722057,0.00012687167,0.0017204243,0.000020555583,0.0064163525],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999931,0.00001487962,0.0000068852123,0.000009295777,0.000014527603,0.000023414756],"domain_scores_gemma":[0.999933,0.000013366007,0.000013524595,0.000007081229,0.000011713381,0.000021359938],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002815416,0.00033898026,0.00031562944,0.00021133716,0.00017282994,0.0002151758,0.0004145581,0.00023656577,0.0022687519],"category_scores_gemma":[0.00016535277,0.00019316822,0.00018169526,0.00019726362,0.0001641878,0.00021264088,0.00017048366,0.00048038468,0.0006044515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008661355,0.0003448867,0.00023605562,0.00031449346,0.000027400185,0.00042500428,0.00013639641,0.0033262603,0.98034245,0.000878616,0.0008823047,0.012220109],"study_design_scores_gemma":[0.0009089577,0.008352934,0.003025287,0.000030565825,0.00009983143,0.0008513149,0.00007059752,0.0050947787,0.95803094,0.00023776747,0.023253584,0.000043481676],"about_ca_topic_score_codex":0.0011422993,"about_ca_topic_score_gemma":0.003093557,"teacher_disagreement_score":0.0022687519,"about_ca_system_score_codex":0.00037832616,"about_ca_system_score_gemma":0.00033884714,"threshold_uncertainty_score":0.0075897574},"labels":[],"label_agreement":null},{"id":"W2125945623","doi":"10.1016/j.bmcl.2013.05.037","title":"Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Quinazolinone; NS5B; Allosteric regulation; Stereochemistry; Linker; Replicon; ADME; Biochemistry; In vitro; Enzyme","score_opus":0.018032526931393233,"score_gpt":0.23810969845216703,"score_spread":0.2200771715207738,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2125945623","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9664981,0.0062972903,0.016020462,0.00071854953,0.00010626023,0.0006845224,0.0010102672,0.00047795,0.008186584],"genre_scores_gemma":[0.986139,0.0023802281,0.0076914066,0.00021626522,0.000015234213,0.00011907817,0.0006306234,0.000024784422,0.002783354],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999193,0.000013195149,0.000005232465,0.0000132600535,0.000018791183,0.000030182517],"domain_scores_gemma":[0.9999485,0.000007824988,0.000013498105,0.000004213285,0.000009520908,0.000016474909],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023436072,0.00056220626,0.0005469801,0.0002901108,0.00027125987,0.0005531334,0.00063806475,0.00025942846,0.0030777007],"category_scores_gemma":[0.00020582462,0.0002789204,0.00028749558,0.00016879257,0.00021659938,0.00023257414,0.000313119,0.0005835087,0.0005070785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017771203,0.0005495895,0.0010369242,0.00039337974,0.000070008675,0.00072847476,0.00015607922,0.024361646,0.9226054,0.0028156969,0.001707248,0.043798406],"study_design_scores_gemma":[0.005395674,0.015376132,0.0066611106,0.00015556972,0.00039492562,0.0019945158,0.00025468544,0.075596996,0.85438323,0.0018313031,0.03772666,0.00022916432],"about_ca_topic_score_codex":0.0015629557,"about_ca_topic_score_gemma":0.00684322,"teacher_disagreement_score":0.0030777007,"about_ca_system_score_codex":0.0007143312,"about_ca_system_score_gemma":0.00062803266,"threshold_uncertainty_score":0.010295987},"labels":[],"label_agreement":null},{"id":"W2126146482","doi":"10.1016/j.bmcl.2009.10.083","title":"Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Structural isomer; Moiety; Stereochemistry; Salicylic acid; Diflunisal; Aspirin; Chemical synthesis; Biochemistry; In vitro; Pharmacology","score_opus":0.019919432623908336,"score_gpt":0.25913261171767044,"score_spread":0.2392131790937621,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2126146482","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98791283,0.004535745,0.0038598953,0.00007095677,0.000040231327,0.00012315014,0.00041704843,0.0000854197,0.0029546043],"genre_scores_gemma":[0.9922003,0.002261045,0.0029340137,0.000034469682,0.000016296945,0.000050246683,0.00045332772,0.000016329614,0.002034007],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998246,0.000037986927,0.00001899648,0.000023596407,0.000045715267,0.000049121994],"domain_scores_gemma":[0.9998846,0.00001324204,0.000033503944,0.000014884379,0.000020960073,0.000032811204],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002900173,0.00038755997,0.00037588517,0.0002793435,0.00016807466,0.00017935157,0.00035060066,0.00028411322,0.0011588443],"category_scores_gemma":[0.00022338376,0.00019069514,0.00029266352,0.00022205446,0.00020229603,0.0001982273,0.00016940592,0.00025102735,0.00043323982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043034513,0.00007830074,0.000084243664,0.000040882314,0.000009534981,0.00007100207,0.000022197482,0.00027932183,0.9953832,0.00014648774,0.000041526793,0.0034129668],"study_design_scores_gemma":[0.000083168794,0.0018073115,0.00096519646,0.000004083227,0.00003081401,0.00018287428,0.000015246712,0.0003809874,0.9942714,0.000022299946,0.0022279902,0.00000869703],"about_ca_topic_score_codex":0.0011257972,"about_ca_topic_score_gemma":0.0016578346,"teacher_disagreement_score":0.0011588443,"about_ca_system_score_codex":0.00026723096,"about_ca_system_score_gemma":0.00036754084,"threshold_uncertainty_score":0.003876686},"labels":[],"label_agreement":null},{"id":"W2126664383","doi":"10.1016/s0960-894x(02)01045-4","title":"Pyridazinones as selective cyclooxygenase-2 inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Cyclooxygenase; Pharmacology; Enzyme inhibitor; Enzyme; Biochemistry","score_opus":0.005133143473262556,"score_gpt":0.22052743949336237,"score_spread":0.21539429602009982,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2126664383","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8582279,0.10441679,0.010566172,0.001219851,0.0007835367,0.00026523913,0.0011048075,0.0007849536,0.022630647],"genre_scores_gemma":[0.9526844,0.03320077,0.0025534753,0.00024176844,0.00009706907,0.00008203477,0.0006395171,0.000023079927,0.010477863],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991405,0.000014070423,0.000005608321,0.000011100082,0.000022343032,0.000032931046],"domain_scores_gemma":[0.99996686,0.0000060123493,0.000007846512,0.000003676194,0.0000043528003,0.000011230383],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019000599,0.00034433661,0.00044092015,0.00028959097,0.00017886383,0.0003809277,0.00045510998,0.00027733337,0.0017655477],"category_scores_gemma":[0.00012276656,0.00024635918,0.00013167522,0.00023460978,0.00019277116,0.0003442173,0.00030845654,0.00072634075,0.0005014837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0033530546,0.00025783095,0.0007366871,0.00085173565,0.00007261964,0.0007798339,0.0001501026,0.0027426458,0.87159204,0.0052851564,0.0042490456,0.10992929],"study_design_scores_gemma":[0.0021158434,0.0059422744,0.0058970633,0.00008287772,0.00024550964,0.002065484,0.00008408015,0.005801216,0.88289976,0.0010091803,0.093784764,0.000071945076],"about_ca_topic_score_codex":0.0009460134,"about_ca_topic_score_gemma":0.0028592043,"teacher_disagreement_score":0.0017655477,"about_ca_system_score_codex":0.00039365288,"about_ca_system_score_gemma":0.0002136275,"threshold_uncertainty_score":0.0059063435},"labels":[],"label_agreement":null},{"id":"W2126819751","doi":"10.1016/j.bmcl.2004.09.014","title":"Determination of the enantiomeric purity of the phytoalexins spirobrassinins by 1H NMR using chiral solvation","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Molecular spectroscopy and chirality","field":"Chemistry","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Enantiomer; Solvation; Enantiomeric excess; Proton NMR; Ethanol; Organic chemistry; High-performance liquid chromatography; Chromatography; Stereochemistry; Enantioselective synthesis; Molecule; Catalysis","score_opus":0.009148911731347673,"score_gpt":0.22977141207271293,"score_spread":0.22062250034136527,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2126819751","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.953696,0.0012342065,0.034456227,0.00037118452,0.00006208836,0.000065868015,0.00097220123,0.0003337984,0.008808455],"genre_scores_gemma":[0.9827307,0.0010354328,0.012729218,0.00016640508,0.000021153832,0.000027545577,0.0009026169,0.00009857303,0.002288359],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999542,0.000113644535,0.000024280065,0.00007110079,0.00013334451,0.00011564562],"domain_scores_gemma":[0.99956745,0.00012332866,0.00006674542,0.00007593393,0.00010907583,0.0000575785],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00061608956,0.0004375056,0.00026773516,0.0003528866,0.0004375959,0.00045822706,0.00035223304,0.0003452616,0.0016462494],"category_scores_gemma":[0.0007753991,0.0002527071,0.00018653482,0.00036780338,0.00046896245,0.00032412793,0.00024157848,0.00071306614,0.00064724684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009263398,0.000015038839,0.00013908553,0.000013126418,0.0000059826702,0.000026896596,0.000021512085,0.000080893464,0.9974638,0.00017760966,0.000049681657,0.0019137444],"study_design_scores_gemma":[0.000007713272,0.00003929563,0.0003608287,0.0000019664835,0.0000045647525,0.000037617825,0.000011743973,0.00036170584,0.99868447,0.000039455605,0.00044676897,0.0000039003944],"about_ca_topic_score_codex":0.00095727755,"about_ca_topic_score_gemma":0.0018145285,"teacher_disagreement_score":0.0016462494,"about_ca_system_score_codex":0.00035589823,"about_ca_system_score_gemma":0.00035780386,"threshold_uncertainty_score":0.0055072308},"labels":[],"label_agreement":null},{"id":"W2128232386","doi":"10.1016/s0960-894x(03)00314-7","title":"Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Phosphodiesterase; Bronchoconstriction; Structure–activity relationship; In vitro; Pharmacology; Enzyme inhibitor; Pharmacokinetics; Chemical synthesis; In vivo; Biological activity; Enzyme; Stereochemistry; Biochemistry; Internal medicine","score_opus":0.005854056008029573,"score_gpt":0.2116811482564522,"score_spread":0.20582709224842263,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2128232386","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93686545,0.033510998,0.00751459,0.00060449616,0.0005101161,0.0001897629,0.0008537181,0.0005707611,0.01938001],"genre_scores_gemma":[0.9741813,0.013503997,0.0029492907,0.00020386993,0.00008900304,0.000078838486,0.0006477484,0.000031783715,0.00831417],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998982,0.000017840983,0.0000064555156,0.000012966639,0.00002560421,0.000038878607],"domain_scores_gemma":[0.99996483,0.0000072137927,0.000007496581,0.000004682806,0.0000043334326,0.000011440464],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023087909,0.0005466518,0.00047147245,0.00030384844,0.00017636384,0.00023051004,0.0006573682,0.00033251708,0.002565384],"category_scores_gemma":[0.00013826859,0.0002204144,0.00019684556,0.00026805903,0.00019409152,0.0002667458,0.00028152496,0.0006844521,0.0005852456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014134898,0.00029409002,0.00022148412,0.00031665107,0.000043759293,0.0004718094,0.00007421414,0.002713961,0.9521202,0.0015558741,0.0014333097,0.039341252],"study_design_scores_gemma":[0.0006405152,0.003953796,0.0023288308,0.000031592575,0.00008339919,0.0007267422,0.000035861263,0.0029292936,0.96866727,0.00027369204,0.020288272,0.000040854906],"about_ca_topic_score_codex":0.00089276995,"about_ca_topic_score_gemma":0.002750626,"teacher_disagreement_score":0.002565384,"about_ca_system_score_codex":0.00038952494,"about_ca_system_score_gemma":0.0002420807,"threshold_uncertainty_score":0.008582056},"labels":[],"label_agreement":null},{"id":"W2128730739","doi":"10.1016/j.bmcl.2010.12.070","title":"Difluoroethylamines as an amide isostere in inhibitors of cathepsin K","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Isostere; Cathepsin; Cathepsin K; Amide; Selectivity; Stereochemistry; Potency; Bioavailability; Cathepsin S; Cathepsin L; Biochemistry; Pharmacology; Enzyme; In vitro","score_opus":0.003989454053911978,"score_gpt":0.23014670010773758,"score_spread":0.2261572460538256,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2128730739","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9610651,0.017510692,0.0058113476,0.0005338107,0.00028474108,0.00020387853,0.0004905647,0.00020399834,0.013895834],"genre_scores_gemma":[0.9843061,0.007857014,0.0019598694,0.00015572147,0.00006399408,0.00005111077,0.0002723765,0.000022747741,0.0053110793],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998466,0.00004208031,0.000015204621,0.000020126068,0.00002271964,0.00005320292],"domain_scores_gemma":[0.99993014,0.000019094483,0.000015878628,0.000008921913,0.0000102013555,0.00001568961],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004984791,0.00043917153,0.00037489674,0.00031772075,0.00020908713,0.00028954432,0.0005386321,0.00046840866,0.0017305549],"category_scores_gemma":[0.00021432135,0.00025087755,0.000302907,0.00017525259,0.0002122307,0.0004762525,0.00024698596,0.0005719575,0.0005270085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037929069,0.0003712153,0.00039320186,0.00036042064,0.000089652756,0.000871318,0.00019673888,0.0027441815,0.9493127,0.002615429,0.0014489657,0.03780332],"study_design_scores_gemma":[0.0010383703,0.0081604635,0.0017034177,0.000053347674,0.00015290247,0.0012287607,0.00006743386,0.00212879,0.9585401,0.000366444,0.026501723,0.000058265323],"about_ca_topic_score_codex":0.0008598406,"about_ca_topic_score_gemma":0.0016191516,"teacher_disagreement_score":0.0017305549,"about_ca_system_score_codex":0.00033381968,"about_ca_system_score_gemma":0.00018962573,"threshold_uncertainty_score":0.00578928},"labels":[],"label_agreement":null},{"id":"W2129082893","doi":"10.1016/j.bmcl.2005.04.003","title":"Biaryl isoxazolinone antibacterial agents","year":2005,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Catalytic Cross-Coupling Reactions","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Antibacterial activity; Antibiotics; Bacteria; Antibacterial agent; Combinatorial chemistry; Stereochemistry; Biochemistry; Biology","score_opus":0.015331137256685745,"score_gpt":0.25948349978418334,"score_spread":0.24415236252749759,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2129082893","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.74726313,0.08341692,0.05497198,0.0016410446,0.0012734176,0.0003691349,0.0009639626,0.0012910101,0.10880937],"genre_scores_gemma":[0.9397477,0.020353803,0.0068051326,0.00037393355,0.00014150816,0.00014026789,0.00048924814,0.000042004587,0.03190641],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998765,0.000026727508,0.000010007353,0.000018687942,0.000033069,0.000035099158],"domain_scores_gemma":[0.99995613,0.0000054085976,0.000012332325,0.0000061772193,0.000010367009,0.000009604874],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021895154,0.000466518,0.000255922,0.00037033574,0.0001718987,0.00023601831,0.0003051359,0.00030312856,0.0027664143],"category_scores_gemma":[0.00014151615,0.00013542584,0.00014124492,0.00021564162,0.00010842226,0.00032214244,0.00026931323,0.0004971218,0.0010475522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028093474,0.00009526691,0.00012153256,0.00022946595,0.000016532533,0.00020540907,0.000035351164,0.00019269125,0.95835173,0.0024714996,0.0011083763,0.03689114],"study_design_scores_gemma":[0.0001291465,0.001537354,0.0016014028,0.000044777815,0.00005453507,0.0007161534,0.000024049647,0.00085455313,0.94432205,0.00044567083,0.05025165,0.000018731493],"about_ca_topic_score_codex":0.00031770562,"about_ca_topic_score_gemma":0.00080113753,"teacher_disagreement_score":0.0027664143,"about_ca_system_score_codex":0.00023097754,"about_ca_system_score_gemma":0.00014017517,"threshold_uncertainty_score":0.009254515},"labels":[],"label_agreement":null},{"id":"W2129991197","doi":"10.1016/j.bmcl.2005.11.015","title":"Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Estrogen receptor; Sulfonamide; Transcription factor; Estrogen; GPER; Estrogen receptor beta; Receptor; Nuclear receptor; Inflammation; Stereochemistry; Pharmacology; Biochemistry; Internal medicine; Endocrinology; Gene; Biology","score_opus":0.00354245337310238,"score_gpt":0.20679951077384634,"score_spread":0.20325705740074396,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2129991197","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9481434,0.011496394,0.011751858,0.0006773506,0.0003243387,0.000112144706,0.00050573354,0.00045388774,0.026534839],"genre_scores_gemma":[0.97849065,0.0072582765,0.0032331187,0.00020676629,0.000054062268,0.00006350155,0.00029549486,0.000033280165,0.010364856],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999871,0.00003694054,0.000007850483,0.000013162867,0.000024172035,0.000046851565],"domain_scores_gemma":[0.9999418,0.00001363482,0.000013464395,0.000006651154,0.0000088332135,0.000015601001],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030301992,0.00037291046,0.00024467378,0.00021290746,0.00019545056,0.0002226281,0.0005730835,0.00029106328,0.0031867113],"category_scores_gemma":[0.00017907287,0.00015587977,0.00013540221,0.00022570902,0.0002745353,0.00036705012,0.00036417754,0.00039114506,0.00065115374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016354412,0.00018944149,0.00046628856,0.00040327365,0.000029574512,0.0007859728,0.00028602764,0.0036598723,0.9277427,0.015324067,0.0027136824,0.046763636],"study_design_scores_gemma":[0.0002360957,0.0031414824,0.0011664128,0.000032663065,0.00004229262,0.0007226505,0.00013154495,0.004029381,0.93523425,0.0013913322,0.053827927,0.00004392983],"about_ca_topic_score_codex":0.0007661906,"about_ca_topic_score_gemma":0.0015985895,"teacher_disagreement_score":0.0031867113,"about_ca_system_score_codex":0.0004468799,"about_ca_system_score_gemma":0.0003441566,"threshold_uncertainty_score":0.010660589},"labels":[],"label_agreement":null},{"id":"W2130099785","doi":"10.1016/s0960-894x(02)00612-1","title":"Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; AstraZeneca","keywords":"Chemistry; Thrombin; Factor VIIa; Serine protease; Docking (animal); Molecular model; Active site; Stereochemistry; Discovery and development of direct thrombin inhibitors; Serine; Protease; Combinatorial chemistry; Biochemistry; Pharmacology; Enzyme; Tissue factor; Coagulation; Platelet; Immunology","score_opus":0.019374099015869898,"score_gpt":0.21033608878333143,"score_spread":0.19096198976746154,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2130099785","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9561875,0.0158739,0.01852881,0.0006646059,0.000113808725,0.00018474055,0.0004019507,0.00018764369,0.007857127],"genre_scores_gemma":[0.9793392,0.0084424345,0.0075700083,0.00014807984,0.000031772353,0.00006608155,0.00034975883,0.000029154478,0.004023692],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999392,0.000014128677,0.0000054055413,0.0000107204105,0.000012247927,0.00001834019],"domain_scores_gemma":[0.99994636,0.000006992699,0.000017649087,0.0000046703476,0.000008083655,0.000016271822],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017862147,0.00041224502,0.00022108456,0.00020010312,0.00014987813,0.00028665914,0.00045963592,0.00022630357,0.0008653063],"category_scores_gemma":[0.000137316,0.00015093453,0.00016980585,0.00012579562,0.00020549694,0.00024295934,0.00016703538,0.00053285796,0.00043949945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038226723,0.00011558353,0.0001303254,0.00016101496,0.00001061128,0.00024054186,0.00006413173,0.0014377402,0.9823276,0.0018181769,0.00023611463,0.013075852],"study_design_scores_gemma":[0.00015846764,0.0012010226,0.00048226558,0.000015628833,0.000029493029,0.0004959016,0.000030175857,0.0012724147,0.9824723,0.0003988381,0.013427585,0.000015863026],"about_ca_topic_score_codex":0.00029884977,"about_ca_topic_score_gemma":0.00058280805,"teacher_disagreement_score":0.0008653063,"about_ca_system_score_codex":0.00037183907,"about_ca_system_score_gemma":0.00022660865,"threshold_uncertainty_score":0.0028947592},"labels":[],"label_agreement":null},{"id":"W2130304486","doi":"10.1016/j.bmcl.2006.03.100","title":"Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Trifluoromethyl; Chemistry; Thiazole; In vitro; Enzyme; Inhibitory postsynaptic potential; Stereochemistry; Enzyme inhibitor; Chemical synthesis; Biochemistry; Organic chemistry; Internal medicine","score_opus":0.003245683631449921,"score_gpt":0.20029367787834185,"score_spread":0.19704799424689193,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2130304486","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9211352,0.02644426,0.01665686,0.000793624,0.00061192864,0.00023591422,0.00078934943,0.0008824602,0.032450404],"genre_scores_gemma":[0.9818596,0.007097602,0.003781649,0.0002229783,0.00008054618,0.000057545752,0.00044772957,0.00004406963,0.0064082667],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998635,0.000027171393,0.000008585851,0.000017632654,0.000024110404,0.00005905774],"domain_scores_gemma":[0.9999453,0.0000066598095,0.000014307529,0.000007485611,0.00001091375,0.000015329902],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000267592,0.0004278577,0.00038355752,0.00038228845,0.00019869753,0.0002353978,0.00069123943,0.00047304019,0.002005594],"category_scores_gemma":[0.00016070495,0.00013600262,0.00025003342,0.00024896226,0.00015874032,0.0003292977,0.00023613243,0.00049212115,0.0006038253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0023789743,0.00036431104,0.00042758486,0.00033986956,0.00007584608,0.000848671,0.00012817488,0.0025606425,0.9012935,0.0051492346,0.003718922,0.08271428],"study_design_scores_gemma":[0.000704887,0.006218444,0.0020635158,0.000053090418,0.00014895116,0.0015725853,0.00006370085,0.004434659,0.9300048,0.0005659207,0.054094307,0.000075115655],"about_ca_topic_score_codex":0.0012318252,"about_ca_topic_score_gemma":0.0022184795,"teacher_disagreement_score":0.002005594,"about_ca_system_score_codex":0.00039649673,"about_ca_system_score_gemma":0.00018101602,"threshold_uncertainty_score":0.006709397},"labels":[],"label_agreement":null},{"id":"W2130579948","doi":"10.1016/j.bmcl.2010.11.015","title":"Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Antagonist; Chemistry; Pharmacology; Pharmacokinetics; Stereochemistry; Receptor; Biochemistry; Medicine","score_opus":0.00914967195800938,"score_gpt":0.24332913342863416,"score_spread":0.23417946147062477,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2130579948","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.89239484,0.06308371,0.018216679,0.0041843695,0.0009918404,0.00054638024,0.0023629381,0.0007085137,0.017510723],"genre_scores_gemma":[0.95966554,0.0239036,0.007036251,0.0010065684,0.00030326634,0.00013178584,0.0012439071,0.000036960304,0.0066722506],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987733,0.000024211107,0.0000092769915,0.000020413945,0.000027538796,0.00004122315],"domain_scores_gemma":[0.9999516,0.0000073763963,0.000008971301,0.0000043311857,0.000009023187,0.000018729921],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031951262,0.0004955877,0.0009309828,0.00032051027,0.00022906401,0.0006415778,0.00042689955,0.0005731953,0.001782327],"category_scores_gemma":[0.000190922,0.00026186855,0.00040248942,0.00019463417,0.0002516288,0.00031344246,0.00025686828,0.0010496845,0.0008603033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002899785,0.00028350233,0.00066125183,0.00043396733,0.00009664365,0.0011263365,0.000075940654,0.001069938,0.90948296,0.0021963187,0.0033381274,0.078335226],"study_design_scores_gemma":[0.003662073,0.008174023,0.0071326653,0.00007486997,0.00041542476,0.0065434384,0.00008276237,0.0052506127,0.8983473,0.00069402636,0.06953535,0.00008750749],"about_ca_topic_score_codex":0.0003803114,"about_ca_topic_score_gemma":0.0008792036,"teacher_disagreement_score":0.001782327,"about_ca_system_score_codex":0.00041420475,"about_ca_system_score_gemma":0.0004224924,"threshold_uncertainty_score":0.005962491},"labels":[],"label_agreement":null},{"id":"W2130994570","doi":"10.1016/j.bmcl.2008.12.066","title":"Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Moiety; Structural isomer; Stereochemistry; Arachidonate 5-lipoxygenase; Chemical synthesis; Arachidonic acid; Enzyme; In vitro; Organic chemistry; Biochemistry","score_opus":0.019078909446564176,"score_gpt":0.2429043826227847,"score_spread":0.2238254731762205,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2130994570","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9603371,0.0063856784,0.016006326,0.0004549405,0.00024643145,0.0002497149,0.0013184268,0.0002541551,0.01474709],"genre_scores_gemma":[0.98540395,0.0033934384,0.0067564114,0.000099614976,0.000044554185,0.000091618946,0.0005436729,0.000015280108,0.0036514332],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989104,0.000017728711,0.000011325078,0.000013432867,0.000021500304,0.000045039822],"domain_scores_gemma":[0.9999229,0.000007952074,0.000030787905,0.0000072724583,0.000011343512,0.000019784662],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019709686,0.0004181835,0.0002828748,0.00027194037,0.00019419407,0.00016244556,0.0003778313,0.00033790598,0.002054862],"category_scores_gemma":[0.00014511235,0.00017118637,0.00023934156,0.0002465768,0.00014142632,0.0003336832,0.00021695117,0.00030032528,0.0005387243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004657111,0.00014040624,0.0002184886,0.00023448029,0.000023711476,0.00041863864,0.000068052046,0.0007399086,0.97960585,0.0018174257,0.0004606967,0.01580656],"study_design_scores_gemma":[0.00016100759,0.0019317688,0.0021190082,0.000015882486,0.00005093123,0.0005356823,0.000032860225,0.00091278716,0.9798519,0.000183,0.014180451,0.000024712468],"about_ca_topic_score_codex":0.00043392842,"about_ca_topic_score_gemma":0.0009988782,"teacher_disagreement_score":0.002054862,"about_ca_system_score_codex":0.00019938436,"about_ca_system_score_gemma":0.0004282176,"threshold_uncertainty_score":0.0068742037},"labels":[],"label_agreement":null},{"id":"W2133428384","doi":"10.1016/s0960-894x(01)00778-8","title":"New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D2 Template","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Derivative (finance); Stereochemistry; Dopaminergic; Resolution (logic); Bicyclic molecule; Combinatorial chemistry; Chemical synthesis; Dopamine; In vitro; Biochemistry","score_opus":0.05018907009406931,"score_gpt":0.2330683860108327,"score_spread":0.1828793159167634,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2133428384","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6997657,0.14306486,0.054190446,0.0020645752,0.00199298,0.0010744217,0.0023127713,0.0012342476,0.094300054],"genre_scores_gemma":[0.86467177,0.05863619,0.015572508,0.0016798046,0.00059970724,0.00048152,0.001803013,0.000110044726,0.05644541],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999949,0.0000063878388,0.0000030136227,0.000010469239,0.00001247362,0.000018713876],"domain_scores_gemma":[0.99996877,0.0000074648415,0.000006816446,0.0000053944073,0.0000032461978,0.0000083729765],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018270148,0.0004084138,0.00026228133,0.00037445652,0.00014320906,0.0002141614,0.00064440194,0.00051237195,0.0032129409],"category_scores_gemma":[0.00009921809,0.00019198022,0.0003478573,0.00016055653,0.00024584157,0.00039400824,0.00020773032,0.00049259537,0.0011703277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011186908,0.0009085435,0.00048278796,0.0007104332,0.00007766194,0.00083010655,0.00019544105,0.0027341659,0.7727733,0.012578579,0.009365112,0.19822516],"study_design_scores_gemma":[0.00047545994,0.0062393006,0.0039615864,0.00006255703,0.00010397996,0.0022401724,0.000047215388,0.0021608765,0.82777303,0.0021093679,0.15475048,0.0000760065],"about_ca_topic_score_codex":0.00046476428,"about_ca_topic_score_gemma":0.00080051366,"teacher_disagreement_score":0.0032129409,"about_ca_system_score_codex":0.00030187485,"about_ca_system_score_gemma":0.00020949084,"threshold_uncertainty_score":0.010748327},"labels":[],"label_agreement":null},{"id":"W2133919569","doi":"10.1016/j.bmcl.2012.12.004","title":"Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2′-C-methyl-6-O-methyl guanosine nucleoside and l-Alanine ester phosphoramidates","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Indigenous and Northern Affairs Canada","keywords":"Guanosine; Chemistry; Guanine; Prodrug; Stereochemistry; Nucleoside; Hepatitis C virus; Moiety; Nucleobase; Nucleotide; Nucleic acid; Phosphoramidate; Biochemistry; Virus; Virology; DNA; Biology","score_opus":0.023927361337387563,"score_gpt":0.29201163788902407,"score_spread":0.2680842765516365,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2133919569","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98746824,0.0034211096,0.0028484557,0.00007233915,0.000057051155,0.00012257366,0.0002592557,0.000083177096,0.0056677274],"genre_scores_gemma":[0.99208903,0.0019888296,0.0027250734,0.000046560213,0.00001711705,0.000052035874,0.00041027827,0.000014321402,0.0026567823],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990606,0.000025365189,0.000008261317,0.00001638837,0.000017631384,0.000026297359],"domain_scores_gemma":[0.99993956,0.000009610377,0.000014996151,0.0000065051127,0.000013040119,0.00001627632],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018875966,0.0002913448,0.00033875086,0.00018479672,0.00014785411,0.00016590743,0.0003268908,0.00028719203,0.001446383],"category_scores_gemma":[0.00014439707,0.00016964789,0.00028234077,0.00010593264,0.00013476385,0.00016096904,0.00013611834,0.00029822876,0.000365806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005826814,0.00010082917,0.00009648807,0.0001357729,0.000016490925,0.00015745156,0.000043075208,0.00072822254,0.98888785,0.00027156665,0.000086817454,0.008892731],"study_design_scores_gemma":[0.00012858199,0.004222222,0.00079764525,0.000010600916,0.000050776056,0.0002984895,0.000018530744,0.0008293771,0.9888897,0.000031744436,0.0047105416,0.0000117936725],"about_ca_topic_score_codex":0.000489753,"about_ca_topic_score_gemma":0.00064858276,"teacher_disagreement_score":0.001446383,"about_ca_system_score_codex":0.0001599133,"about_ca_system_score_gemma":0.00019438544,"threshold_uncertainty_score":0.004838705},"labels":[],"label_agreement":null},{"id":"W2136128469","doi":"10.1016/j.bmcl.2006.05.019","title":"Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Valeant Pharmaceuticals International","keywords":"Chemistry; Stereochemistry; Combinatorial chemistry","score_opus":0.0036186011745197714,"score_gpt":0.18667245101142793,"score_spread":0.18305384983690817,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2136128469","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9705244,0.0073951134,0.00964179,0.000430763,0.00014080553,0.00022826392,0.0005090083,0.00028602383,0.010843876],"genre_scores_gemma":[0.9876835,0.0035278634,0.0038071922,0.00010072423,0.00002970035,0.00006732236,0.00036156335,0.0000190164,0.0044031413],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998894,0.000021918342,0.00000688356,0.000011018104,0.000027719989,0.000042945678],"domain_scores_gemma":[0.9999157,0.000014827195,0.000017588194,0.000008022446,0.000019771505,0.000024054429],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027401306,0.0003729364,0.00028035475,0.00024314706,0.00015484943,0.00020666866,0.00045913717,0.00028541396,0.0017003963],"category_scores_gemma":[0.0002330163,0.00019419908,0.00019525367,0.00017193133,0.00016275085,0.0001525545,0.00020967047,0.0005611326,0.00052809744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031871616,0.000113673945,0.00023343762,0.00011034397,0.000014738284,0.00027193702,0.000067456094,0.00084231637,0.98551846,0.0006170319,0.00036730865,0.011524612],"study_design_scores_gemma":[0.00024439473,0.0019667798,0.0028517297,0.000020233569,0.000054239677,0.0005097259,0.000034395325,0.002202,0.9799178,0.00011818721,0.01205988,0.000020580701],"about_ca_topic_score_codex":0.0011553108,"about_ca_topic_score_gemma":0.004555638,"teacher_disagreement_score":0.0017003963,"about_ca_system_score_codex":0.0004323903,"about_ca_system_score_gemma":0.00028544528,"threshold_uncertainty_score":0.005688429},"labels":[],"label_agreement":null},{"id":"W2136317310","doi":"10.1016/s0960-894x(02)00937-x","title":"Sordaricin antifungal agents","year":2003,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Antifungal; Aldehyde; Ether; Combinatorial chemistry; Stereochemistry; Organic chemistry; Catalysis; Microbiology","score_opus":0.015458046320696686,"score_gpt":0.20165903382481012,"score_spread":0.18620098750411343,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2136317310","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.4595565,0.28998846,0.017524319,0.0037235697,0.0043275454,0.0008888362,0.0034957507,0.002604739,0.21789023],"genre_scores_gemma":[0.84446245,0.078628175,0.0056130225,0.0016572676,0.00040582073,0.00014991345,0.003700264,0.000050563252,0.06533253],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998908,0.000015242811,0.000009559188,0.000020193636,0.000031556952,0.000032579363],"domain_scores_gemma":[0.999954,0.000004238965,0.000009688987,0.0000049354912,0.000008753036,0.000018463797],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000121134144,0.0006101647,0.0003171854,0.0004569464,0.00022381998,0.00036415498,0.0002877539,0.00033263693,0.0061237705],"category_scores_gemma":[0.00010821072,0.00011127831,0.0002815623,0.00022165719,0.00020608737,0.00018271072,0.00030976324,0.00091010594,0.002715294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011567934,0.00023309467,0.00041051905,0.0007804303,0.0000480642,0.00083857845,0.000050008424,0.00027435264,0.8210801,0.0037019015,0.0070610307,0.16436523],"study_design_scores_gemma":[0.0004004603,0.0021794713,0.0020720086,0.000092238995,0.00006291233,0.003411252,0.0000450883,0.00027323648,0.658382,0.0006271294,0.33243194,0.000022269085],"about_ca_topic_score_codex":0.00028980145,"about_ca_topic_score_gemma":0.0005142983,"teacher_disagreement_score":0.0061237705,"about_ca_system_score_codex":0.00030336477,"about_ca_system_score_gemma":0.0002446528,"threshold_uncertainty_score":0.020486116},"labels":[],"label_agreement":null},{"id":"W2138916022","doi":"10.1016/s0960-894x(00)00020-2","title":"Pyrrolidine as a cogwheel-like scaffold for the deployment of diverse functionality through cycloaddition reactions of metallo-1,3-dipoles in aqueous media","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Pyrrolidine; Chemistry; Cycloaddition; Scaffold; Aqueous medium; Aqueous solution; Combinatorial chemistry; Chemical synthesis; Organic chemistry; In vitro; Catalysis; Biochemistry; Computer science","score_opus":0.01890097524329752,"score_gpt":0.23668028540051028,"score_spread":0.21777931015721275,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2138916022","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.975897,0.0018427348,0.014788875,0.00018315,0.000101982674,0.000058413567,0.00021114439,0.00040549063,0.006511103],"genre_scores_gemma":[0.99145526,0.0005673718,0.0053801965,0.00003362291,0.0000102103495,0.000017406312,0.00012877453,0.000025404022,0.0023817536],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999124,0.0000120257455,0.000005617936,0.000026430025,0.000015355163,0.000028234013],"domain_scores_gemma":[0.99994624,0.000009010213,0.000014903437,0.000009594708,0.0000048687557,0.000015334816],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014486942,0.0003196787,0.00017176404,0.0001430446,0.0001493396,0.00034942146,0.00041983515,0.0002778039,0.0008575872],"category_scores_gemma":[0.00013141858,0.00015685637,0.00015228344,0.0001630573,0.00021382578,0.0003225124,0.00027663488,0.00032199753,0.00041514597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018101853,0.000031699816,0.00006170221,0.00009225493,0.000005389716,0.00024538918,0.000052421103,0.00057525566,0.98926616,0.0013798792,0.00018860577,0.007920191],"study_design_scores_gemma":[0.000034958186,0.00032565117,0.0004546084,0.0000047254257,0.000009509731,0.00030894933,0.000016386399,0.0015035586,0.9904268,0.0001397578,0.006757995,0.000017128834],"about_ca_topic_score_codex":0.0003907765,"about_ca_topic_score_gemma":0.00086267566,"teacher_disagreement_score":0.0008575872,"about_ca_system_score_codex":0.00029861313,"about_ca_system_score_gemma":0.00016811265,"threshold_uncertainty_score":0.0028689504},"labels":[],"label_agreement":null},{"id":"W2139244800","doi":"10.1016/j.bmcl.2003.12.047","title":"Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Metabolite; Alcohol; Potency; Selectivity; Cyclooxygenase; Pharmacology; Enzyme; Active metabolite; Enzyme inhibitor; Stereochemistry; Derivative (finance); Biochemistry; In vitro; Catalysis","score_opus":0.02228396693622829,"score_gpt":0.27781060547629965,"score_spread":0.25552663854007135,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2139244800","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99320316,0.0037592042,0.0014885447,0.00008236518,0.000029747394,0.00006857746,0.00019862667,0.000038077767,0.0011316678],"genre_scores_gemma":[0.99600005,0.0017883377,0.0009051933,0.000028538705,0.000017223609,0.000025167023,0.00021556088,0.000007934167,0.0010120204],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999696,0.000114573944,0.00003156296,0.000030194893,0.000057336136,0.00007029433],"domain_scores_gemma":[0.999736,0.00011472427,0.000041613395,0.000023857077,0.000046297442,0.000037596754],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005290194,0.00035257288,0.00041719942,0.00030833512,0.00024234303,0.00025066693,0.00025544956,0.0002565792,0.0017338771],"category_scores_gemma":[0.00050249597,0.00019168427,0.0002625603,0.00026736883,0.00022188324,0.0003486787,0.00014661669,0.0004020469,0.00030388116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0040429463,0.0003620374,0.0006516154,0.00007903604,0.000033012042,0.00011919551,0.000061397615,0.00054998987,0.9837923,0.00010684106,0.000083178784,0.010118578],"study_design_scores_gemma":[0.00018317832,0.0060701272,0.0015597733,0.000004815793,0.000053584085,0.00017687227,0.00002661113,0.00049560936,0.99038833,0.000018002556,0.0010141409,0.000008989624],"about_ca_topic_score_codex":0.000909802,"about_ca_topic_score_gemma":0.0014004309,"teacher_disagreement_score":0.0017338771,"about_ca_system_score_codex":0.000204201,"about_ca_system_score_gemma":0.00034145452,"threshold_uncertainty_score":0.0058003664},"labels":[],"label_agreement":null},{"id":"W2139514746","doi":"10.1016/s0960-894x(03)00331-7","title":"Unexpected inhibition of S-adenosyl-l-homocysteine hydrolase by a guanosine nucleoside","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Kimberly-Clark (Canada)","funders":"Georgia Institute of Technology","keywords":"Guanosine; Chemistry; Nucleoside; Adenosine; Stereochemistry; Hydrolase; Biochemistry; Inhibitory postsynaptic potential; Enzyme; Biology","score_opus":0.0048182266869760395,"score_gpt":0.2132956713724633,"score_spread":0.20847744468548726,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2139514746","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97697973,0.0047173053,0.007510763,0.0004889116,0.0002121754,0.00006115438,0.0005395563,0.00030853943,0.009181897],"genre_scores_gemma":[0.9951711,0.0010844319,0.0013751163,0.000061565814,0.000028930317,0.000022392274,0.0002082673,0.000018663754,0.0020294304],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989736,0.000015938384,0.000008090015,0.000017848355,0.000027028975,0.000033641823],"domain_scores_gemma":[0.999944,0.000017485332,0.0000101265305,0.000010200194,0.0000062308545,0.000012003622],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015263671,0.0003787038,0.00025017103,0.00014761872,0.00017921891,0.00032732054,0.00039702514,0.00036892502,0.0009356925],"category_scores_gemma":[0.00018617605,0.00014777688,0.0002197903,0.00011128935,0.00018967346,0.00015958124,0.00022480548,0.0004912688,0.00033865805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003181338,0.000033787695,0.000115514405,0.000062321655,0.000017732033,0.00044220217,0.00001690828,0.00018402377,0.99452966,0.0006491226,0.00023031904,0.0034002818],"study_design_scores_gemma":[0.000021686881,0.00014997908,0.00034528726,0.0000015449987,0.000010884516,0.0003315104,0.0000037966588,0.0005972878,0.9966934,0.00007966058,0.0017617571,0.0000031510426],"about_ca_topic_score_codex":0.0005508917,"about_ca_topic_score_gemma":0.00073716615,"teacher_disagreement_score":0.0009356925,"about_ca_system_score_codex":0.00033423622,"about_ca_system_score_gemma":0.00020285153,"threshold_uncertainty_score":0.0031302571},"labels":[],"label_agreement":null},{"id":"W2142413196","doi":"10.1016/s0960-894x(03)00759-5","title":"4-(2-Pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":50,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Piperazine; Chemistry; Carboxamide; Antagonist; Stereochemistry; Pharmacology; In vitro; Chemical synthesis; Lead compound; HEK 293 cells; Capsaicin; Structure–activity relationship; Receptor; Biochemistry","score_opus":0.01723489852751881,"score_gpt":0.22572918809276696,"score_spread":0.20849428956524815,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2142413196","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90763974,0.052669078,0.01302532,0.0014050826,0.0006371573,0.00030250152,0.0008269036,0.00067496026,0.02281934],"genre_scores_gemma":[0.947235,0.0336213,0.0051078047,0.0005304769,0.0002754822,0.00015968992,0.000711028,0.000048149876,0.012311037],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992037,0.000012792704,0.0000054289667,0.000011282698,0.000015706239,0.000034381042],"domain_scores_gemma":[0.99995756,0.000007725814,0.000013403278,0.0000028213794,0.0000047729095,0.000013787658],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021287822,0.0004229945,0.0004729387,0.00023697889,0.00014495081,0.00026167836,0.00044281245,0.00027507133,0.0019087293],"category_scores_gemma":[0.00018675743,0.00019218352,0.00013560482,0.00017019018,0.00017637039,0.00035258668,0.00019462749,0.000716713,0.00065357884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018806411,0.00022033163,0.00023925143,0.00042168112,0.000032988228,0.00043039516,0.00010320641,0.001379411,0.9314095,0.0029574772,0.0023509066,0.05857428],"study_design_scores_gemma":[0.0044616177,0.016999744,0.011428943,0.00015441635,0.00029334886,0.005031323,0.00015198613,0.0068112467,0.8012958,0.001968787,0.15127876,0.00012403741],"about_ca_topic_score_codex":0.00041807152,"about_ca_topic_score_gemma":0.0014518932,"teacher_disagreement_score":0.0019087293,"about_ca_system_score_codex":0.0002537189,"about_ca_system_score_gemma":0.00019657043,"threshold_uncertainty_score":0.0063853264},"labels":[],"label_agreement":null},{"id":"W2144208692","doi":"10.1016/j.bmcl.2005.02.011","title":"Synthesis of 15R-PGD2: a potential DP2 receptor agonist","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Christie (Canada); McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Chemistry; Agonist; Receptor; Partial agonist; Pharmacology; Stereochemistry; Biochemistry","score_opus":0.004970151887301506,"score_gpt":0.21147055579143015,"score_spread":0.20650040390412863,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2144208692","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7877024,0.012983201,0.10228028,0.002685944,0.0013962635,0.0024588925,0.0124947075,0.0012899763,0.076708466],"genre_scores_gemma":[0.9426595,0.0046692304,0.02386522,0.00047582478,0.00015569966,0.00043689378,0.0035014907,0.00007909845,0.024157044],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998062,0.000027623266,0.00001816415,0.00003191838,0.00002799738,0.000088108965],"domain_scores_gemma":[0.9999083,0.000008666759,0.000010665157,0.000010285369,0.000013649298,0.00004837878],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000277681,0.0005847566,0.000517323,0.00040588746,0.00038612634,0.00030966522,0.00062208995,0.0005716155,0.008262759],"category_scores_gemma":[0.00019062859,0.00026925007,0.00035361282,0.00041693047,0.00026023283,0.0003996571,0.0005162548,0.00057801045,0.0034471767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017214273,0.00068193296,0.0006698436,0.0013232593,0.00015559312,0.0045768777,0.0003463701,0.006402078,0.9124633,0.0072999704,0.0046306322,0.05972873],"study_design_scores_gemma":[0.00041324852,0.002177245,0.0013737241,0.000052038868,0.0000929116,0.0015801104,0.00008572611,0.0017536008,0.9299947,0.0010093328,0.061392095,0.00007524146],"about_ca_topic_score_codex":0.00087105605,"about_ca_topic_score_gemma":0.0010680128,"teacher_disagreement_score":0.008262759,"about_ca_system_score_codex":0.00047409465,"about_ca_system_score_gemma":0.001082128,"threshold_uncertainty_score":0.027641654},"labels":[],"label_agreement":null},{"id":"W2144360055","doi":"10.1016/j.bmcl.2004.06.063","title":"Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":75,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"DNA gyrase; Chemistry; Antibacterial activity; Antibacterial agent; Gram; Stereochemistry; In vitro; Potency; Structure–activity relationship; Antibiotics; Chemical synthesis; Combinatorial chemistry; Escherichia coli; Bacteria; Biochemistry; Biology; Genetics","score_opus":0.01873872148372895,"score_gpt":0.23567547288065985,"score_spread":0.2169367513969309,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2144360055","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9725395,0.017052287,0.003193869,0.00018962457,0.000060666694,0.0001531809,0.0005697036,0.000078638994,0.0061625293],"genre_scores_gemma":[0.99254346,0.0033156855,0.0015396924,0.00006943423,0.000019484818,0.000025567992,0.0004256381,0.0000083888635,0.0020525935],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991965,0.000020115487,0.000009617795,0.000010938876,0.000016428276,0.000023189157],"domain_scores_gemma":[0.9999074,0.000023058456,0.000025077694,0.0000074517093,0.000016918873,0.000020117983],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023460355,0.0002523871,0.0002844016,0.00032501292,0.0001411317,0.0002482715,0.00031125674,0.0001679196,0.002119842],"category_scores_gemma":[0.00020007526,0.000153175,0.00020885839,0.00016627327,0.00017126898,0.00019170145,0.00013090167,0.00027705877,0.0003985007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007688174,0.00024769362,0.0005052743,0.00017370842,0.000024418894,0.00023028895,0.00007721625,0.0013404284,0.9785219,0.0006936638,0.00021977887,0.017196838],"study_design_scores_gemma":[0.00026814468,0.005127516,0.005184189,0.00001979689,0.0000845851,0.00037492017,0.0000352342,0.0013626877,0.9768266,0.00016906367,0.010526761,0.000020549378],"about_ca_topic_score_codex":0.000754566,"about_ca_topic_score_gemma":0.0016196627,"teacher_disagreement_score":0.002119842,"about_ca_system_score_codex":0.00028941158,"about_ca_system_score_gemma":0.00024361115,"threshold_uncertainty_score":0.007091582},"labels":[],"label_agreement":null},{"id":"W2144464230","doi":"10.1016/j.bmcl.2004.12.068","title":"Lysine derivatives as potent HIV protease inhibitors. Discovery, synthesis and structure–activity relationship studies","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SNC-Lavalin (Canada)","funders":"","keywords":"Chemistry; Protease; Proteases; Enzyme; Enzyme inhibitor; Lysine; Biochemistry; Pepsin; Arginine; Cathepsin; Structure–activity relationship; Ornithine; Stereochemistry; Amino acid; In vitro","score_opus":0.01706852400378075,"score_gpt":0.2620541486762605,"score_spread":0.24498562467247972,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2144464230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93606687,0.04610629,0.0056480644,0.00030450255,0.00014679367,0.000215521,0.0009943887,0.00013060146,0.010387072],"genre_scores_gemma":[0.9680942,0.022794137,0.0031039603,0.00015011588,0.00003621839,0.000035098306,0.00064621423,0.000018160275,0.005121869],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998809,0.00002331692,0.000011219806,0.000017922257,0.000031413532,0.000035127276],"domain_scores_gemma":[0.99992967,0.000016333115,0.000016344256,0.0000071869995,0.000011277791,0.000019134613],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003081788,0.0003644575,0.00034540892,0.00021504864,0.00016752283,0.0002674874,0.00041412798,0.00022395318,0.001858925],"category_scores_gemma":[0.00021798398,0.00019262012,0.00021600543,0.00022078039,0.00020671537,0.00033061416,0.00018052271,0.0004383478,0.0004942015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0032207924,0.00075815263,0.00068592187,0.00061838474,0.000082861035,0.00059606775,0.00010811869,0.002496258,0.93251276,0.001519164,0.0009796523,0.05642193],"study_design_scores_gemma":[0.00096376194,0.010763606,0.003119243,0.00003106078,0.00016374914,0.0010792849,0.000036279427,0.0013148889,0.96148306,0.00027836606,0.020726865,0.00003983938],"about_ca_topic_score_codex":0.0007556165,"about_ca_topic_score_gemma":0.0016496511,"teacher_disagreement_score":0.001858925,"about_ca_system_score_codex":0.0003118835,"about_ca_system_score_gemma":0.00020427324,"threshold_uncertainty_score":0.0062187314},"labels":[],"label_agreement":null},{"id":"W2145327037","doi":"10.1016/j.bmcl.2004.12.006","title":"Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; In vivo; Chemical synthesis; In vitro; Caspase; Stereochemistry; Combinatorial chemistry; Apoptosis; Biochemistry; Programmed cell death","score_opus":0.00637830334298718,"score_gpt":0.20720744859955606,"score_spread":0.2008291452565689,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2145327037","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9380353,0.02137782,0.014386142,0.0006356807,0.00030919208,0.00037129954,0.0006455376,0.0005228418,0.023716256],"genre_scores_gemma":[0.98446125,0.005866783,0.003554468,0.00014505722,0.000039281425,0.00008885107,0.0003040363,0.000015702975,0.005524544],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999155,0.000018569373,0.0000065106474,0.000010822178,0.000020215175,0.00002832758],"domain_scores_gemma":[0.9999621,0.00000625248,0.000011386769,0.0000044590042,0.000004676304,0.00001106143],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025857947,0.00044292596,0.00024924133,0.00019967277,0.00014170048,0.0002305443,0.00042523976,0.00025494225,0.0020757932],"category_scores_gemma":[0.000111373956,0.0001884771,0.0001550749,0.00013990409,0.00017223357,0.00031826706,0.00026022267,0.000620396,0.0004931443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008240761,0.00022998825,0.00015620231,0.00031723853,0.000026946454,0.00040730584,0.000092725095,0.0015254077,0.9553751,0.0021055806,0.0011232215,0.03781612],"study_design_scores_gemma":[0.0006411642,0.005185,0.001643437,0.000030052497,0.00005559988,0.001055433,0.000032742264,0.0024402537,0.9646801,0.00043918221,0.02376495,0.000032219985],"about_ca_topic_score_codex":0.0002008961,"about_ca_topic_score_gemma":0.00065164943,"teacher_disagreement_score":0.0020757932,"about_ca_system_score_codex":0.00025283557,"about_ca_system_score_gemma":0.0001600944,"threshold_uncertainty_score":0.006944239},"labels":[],"label_agreement":null},{"id":"W2147020837","doi":"10.1016/j.bmcl.2005.03.073","title":"Synthesis and bladder smooth muscle relaxing properties of substituted 3-amino-4-aryl-(and aralkyl-)cyclobut-3-ene-1,2-diones","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Iberiotoxin; Potassium channel; Aryl; Stereochemistry; Potassium; Organic chemistry; Biophysics","score_opus":0.011784236204183994,"score_gpt":0.1970128676703297,"score_spread":0.18522863146614568,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2147020837","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9818419,0.0037172555,0.004223354,0.00025564394,0.00016799166,0.0000915535,0.0007131289,0.000112741895,0.0088764755],"genre_scores_gemma":[0.990045,0.0023998008,0.002800639,0.00007361347,0.000025900687,0.000051901825,0.00042855187,0.000029006811,0.004145497],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998841,0.000023759927,0.000013866644,0.000013434848,0.00001732501,0.000047538735],"domain_scores_gemma":[0.9998585,0.000030835432,0.000029936564,0.000015162057,0.000018072757,0.000047492696],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759899,0.00041706802,0.00026751214,0.00020403985,0.00017164566,0.00024551924,0.0003828344,0.00027161257,0.002311621],"category_scores_gemma":[0.00023361514,0.00018057159,0.00019677031,0.00020958672,0.00019292066,0.00021581605,0.0002282284,0.0004465049,0.00070385874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00057397876,0.000065188324,0.0001381961,0.00015740267,0.000010996041,0.000387265,0.000095263465,0.0005299923,0.9908764,0.000612818,0.0001609893,0.006391571],"study_design_scores_gemma":[0.00011935491,0.0010440984,0.0017742488,0.000023283521,0.000027882917,0.00020963266,0.000040268627,0.00068003853,0.9902018,0.0000855772,0.0057692663,0.000024568038],"about_ca_topic_score_codex":0.0008726764,"about_ca_topic_score_gemma":0.0013521899,"teacher_disagreement_score":0.002311621,"about_ca_system_score_codex":0.00026718588,"about_ca_system_score_gemma":0.00038345734,"threshold_uncertainty_score":0.0077331066},"labels":[],"label_agreement":null},{"id":"W2149148148","doi":"10.1016/j.bmcl.2013.12.070","title":"Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Reverse transcriptase; Reverse-transcriptase inhibitor; Nucleoside Reverse Transcriptase Inhibitor; Nucleoside; Mutant; Chemistry; Virology; Nucleotidyltransferase; Bioavailability; Pharmacokinetics; Human immunodeficiency virus (HIV); Lentivirus; Pharmacology; RNA; Biology; Viral disease; Biochemistry","score_opus":0.01159597471099505,"score_gpt":0.2173978595742735,"score_spread":0.20580188486327844,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2149148148","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9545472,0.014789052,0.012345708,0.00093121885,0.00023685861,0.00035988397,0.0017798473,0.00036496663,0.01464515],"genre_scores_gemma":[0.9747449,0.009343785,0.006428216,0.00030643123,0.000045943238,0.00005604496,0.0015190331,0.000039277023,0.0075163497],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999393,0.000009573582,0.0000042678694,0.00000970674,0.000019731888,0.00001735681],"domain_scores_gemma":[0.9999615,0.000005973476,0.0000067456103,0.000003238716,0.0000064817114,0.000016028902],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017048123,0.00037794997,0.00046190762,0.0002487345,0.00015214397,0.0005023633,0.0004447959,0.0003110897,0.0015563774],"category_scores_gemma":[0.0001410386,0.00020969147,0.00024737883,0.00016062269,0.00018261596,0.00027340764,0.00022311004,0.0008245874,0.00058568816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011544272,0.00051874516,0.0006646111,0.00033833325,0.00006697403,0.00101423,0.00007504593,0.0016921146,0.91684216,0.0019469156,0.0018531212,0.07383333],"study_design_scores_gemma":[0.0016870496,0.0087964805,0.0053402754,0.00006170632,0.00026877545,0.005643234,0.00008335332,0.0060101505,0.91952515,0.00086143217,0.05166623,0.0000562],"about_ca_topic_score_codex":0.00055076723,"about_ca_topic_score_gemma":0.0017819699,"teacher_disagreement_score":0.0015563774,"about_ca_system_score_codex":0.0002683101,"about_ca_system_score_gemma":0.00039395454,"threshold_uncertainty_score":0.005206585},"labels":[],"label_agreement":null},{"id":"W2149590941","doi":"10.1016/j.bmcl.2006.02.062","title":"Identification of an indole series of prostaglandin D2 receptor antagonists","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Indole test; Receptor; Prostaglandin D2; Stereochemistry; IC50; Pharmacology; Biochemistry; In vitro; Biology","score_opus":0.005159303729391729,"score_gpt":0.21312547333021764,"score_spread":0.20796616960082592,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2149590941","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9190062,0.017635882,0.027316598,0.0012897975,0.00033282812,0.0006479308,0.0018164408,0.0005841967,0.031370025],"genre_scores_gemma":[0.95266056,0.007455749,0.014298774,0.0008090484,0.00009835349,0.00023711182,0.0021494355,0.000040455452,0.0222505],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999194,0.000014472399,0.000004550868,0.0000106459065,0.000022624039,0.000028303119],"domain_scores_gemma":[0.9999393,0.000006999215,0.000011565656,0.0000055782816,0.000013472337,0.000023054397],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017252269,0.0003188234,0.00034069153,0.00034869814,0.00026112184,0.00033179446,0.00048255367,0.0002573701,0.0028562504],"category_scores_gemma":[0.00017115063,0.00014613962,0.00025609677,0.00017743051,0.00016382484,0.00018842466,0.00023102577,0.00057248655,0.0006642045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00070743554,0.0002529683,0.0005081254,0.000118203934,0.000022711847,0.0004833391,0.000063793006,0.0005255207,0.9604545,0.002060272,0.0014457238,0.033357415],"study_design_scores_gemma":[0.00040087904,0.006370015,0.0073732166,0.00004460996,0.00012189806,0.0017207598,0.00006591429,0.0033523922,0.90906835,0.00068661995,0.07074138,0.000053954587],"about_ca_topic_score_codex":0.0008249784,"about_ca_topic_score_gemma":0.0023971242,"teacher_disagreement_score":0.0028562504,"about_ca_system_score_codex":0.00043004475,"about_ca_system_score_gemma":0.0003867368,"threshold_uncertainty_score":0.009555101},"labels":[],"label_agreement":null},{"id":"W2150167323","doi":"10.1016/j.bmcl.2010.12.091","title":"Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Substituent; Positron emission tomography; Ring (chemistry); Estrogen; Alkoxy group; Fluorine; Iodine; Radiochemistry; Nuclear medicine; Stereochemistry; Organic chemistry; Internal medicine; Medicine","score_opus":0.014259692421304301,"score_gpt":0.2854555859013617,"score_spread":0.2711958934800574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2150167323","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9653549,0.002803282,0.024986666,0.00014857735,0.000062146835,0.00014755686,0.00039723195,0.000316871,0.005782707],"genre_scores_gemma":[0.9856786,0.001699073,0.009339339,0.00014053151,0.000026634074,0.00007870198,0.00079321716,0.00007478863,0.0021691092],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998228,0.00003379781,0.000017868091,0.000026128137,0.000040736893,0.00005861297],"domain_scores_gemma":[0.99983525,0.000033183293,0.00005210731,0.000016705575,0.00002885259,0.000033852368],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003665712,0.00033801873,0.00024832998,0.00031802987,0.0001742839,0.00029456452,0.00030580166,0.00059576664,0.0010840059],"category_scores_gemma":[0.00039816106,0.00027507526,0.0002963688,0.00039304784,0.0001646156,0.00033190043,0.00025304224,0.00044143235,0.0006903089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016921334,0.000022081314,0.00010835645,0.00002825259,0.000007247407,0.00010348698,0.000016006494,0.00011262582,0.99693465,0.0001737047,0.0000431833,0.0022811266],"study_design_scores_gemma":[0.000037686656,0.00044225127,0.0009827459,0.000006400426,0.000025503716,0.00039821124,0.000009501864,0.0005419258,0.9950224,0.00007419899,0.0024509744,0.000008256654],"about_ca_topic_score_codex":0.00036137932,"about_ca_topic_score_gemma":0.00077731005,"teacher_disagreement_score":0.0010840059,"about_ca_system_score_codex":0.00026601003,"about_ca_system_score_gemma":0.00020661407,"threshold_uncertainty_score":0.0036263466},"labels":[],"label_agreement":null},{"id":"W2150219628","doi":"10.1016/j.bmcl.2004.10.001","title":"Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Guelph","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Chemistry; Pulmonary surfactant; Phosphatidylcholine; Sulfur; Chemical synthesis; Stereochemistry; Organic chemistry; Biochemistry; Phospholipid; In vitro; Membrane","score_opus":0.023009542044399662,"score_gpt":0.3106196996256371,"score_spread":0.2876101575812375,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2150219628","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99805814,0.00034271617,0.00088957546,0.000024185272,0.000006698628,0.000006606175,0.000064312866,0.00001478433,0.0005929428],"genre_scores_gemma":[0.998348,0.0002578807,0.0005623705,0.000015682797,0.0000019086565,0.0000039755996,0.00012657531,0.0000065313434,0.0006770034],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999521,0.0000074885183,0.0000050007698,0.000007423662,0.000013619571,0.000014463765],"domain_scores_gemma":[0.99994075,0.000009533381,0.000018268785,0.0000070743313,0.000012744586,0.00001166843],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000078203375,0.00016377299,0.000101305406,0.0000838931,0.00008818108,0.00014199305,0.00017376618,0.0001390923,0.0006480937],"category_scores_gemma":[0.00017095362,0.00006671207,0.00009592571,0.00012614853,0.0000896719,0.00013323821,0.00009827458,0.00025142112,0.00011367253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000141648,0.0000164382,0.00009732798,0.000016342443,0.0000034972688,0.00004173854,0.000015775871,0.00021892386,0.998281,0.00007370878,0.000015655685,0.0010780394],"study_design_scores_gemma":[0.0000056388353,0.000098669254,0.00031379669,0.000001241126,0.0000053436984,0.00002378809,0.000011842925,0.00053704565,0.99865496,0.000010967235,0.00033510677,0.0000016062514],"about_ca_topic_score_codex":0.0007716141,"about_ca_topic_score_gemma":0.0007924036,"teacher_disagreement_score":0.0007716141,"about_ca_system_score_codex":0.00019285444,"about_ca_system_score_gemma":0.00010429455,"threshold_uncertainty_score":0.0021680593},"labels":[],"label_agreement":null},{"id":"W2151512266","doi":"10.1016/j.bmcl.2011.01.057","title":"Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Tetrazole; Cyclooxygenase; Sodium azide; Potency; Stereochemistry; IC50; Azide; In vitro; Docking (animal); Chemical synthesis; Selectivity; Enzyme; Combinatorial chemistry; Biochemistry; Organic chemistry; Catalysis","score_opus":0.024811324005968145,"score_gpt":0.24701148568223874,"score_spread":0.2222001616762706,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2151512266","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9299812,0.033291318,0.021520596,0.0007263869,0.00056955905,0.0005242382,0.001690881,0.00035960064,0.011336101],"genre_scores_gemma":[0.96539456,0.01550326,0.010923658,0.00019548462,0.000077134675,0.0002189867,0.0012160359,0.000037864058,0.0064330418],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998648,0.00003141201,0.00001859081,0.000017348648,0.000028669969,0.000039052968],"domain_scores_gemma":[0.99993074,0.000008854396,0.00001776013,0.00000924501,0.00001600992,0.00001736933],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036333816,0.0004738622,0.0005339108,0.0003234729,0.00025305332,0.00030230428,0.00068740256,0.00038007324,0.0018244418],"category_scores_gemma":[0.00026421365,0.00027619477,0.0003543017,0.00029456426,0.00020081968,0.00039463467,0.00020538372,0.00051257684,0.00067897234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000815913,0.00036317794,0.00018895749,0.00044139905,0.00005646662,0.00054092513,0.00011606889,0.0017371608,0.9709165,0.0012471611,0.00097267947,0.022603683],"study_design_scores_gemma":[0.0006144285,0.0054123956,0.0012312576,0.00005418422,0.00015322774,0.000874607,0.00004495505,0.0025602933,0.9668305,0.00020622446,0.021976246,0.00004168374],"about_ca_topic_score_codex":0.0004600563,"about_ca_topic_score_gemma":0.0013132247,"teacher_disagreement_score":0.0018244418,"about_ca_system_score_codex":0.00040940975,"about_ca_system_score_gemma":0.00038718682,"threshold_uncertainty_score":0.006103337},"labels":[],"label_agreement":null},{"id":"W2151573674","doi":"10.1016/j.bmcl.2011.07.002","title":"Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":54,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Docking (animal); Stereochemistry; Small molecule; Combinatorial chemistry; Active site; Glutathione; Enzyme; Enzyme inhibitor; Biochemistry","score_opus":0.0780022927870311,"score_gpt":0.2509980223942289,"score_spread":0.17299572960719783,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2151573674","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.976434,0.00879574,0.0082760025,0.00034247283,0.00007837505,0.00039257173,0.0005221569,0.00015682373,0.00500184],"genre_scores_gemma":[0.9800729,0.0072721946,0.0068651354,0.00014096717,0.000033736782,0.00013684704,0.00087638054,0.00002518365,0.004576586],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990964,0.00001994931,0.000007963018,0.000014627945,0.000022832812,0.000024907878],"domain_scores_gemma":[0.99994135,0.0000075008747,0.000013759665,0.0000064628657,0.00001369007,0.000017266817],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000316303,0.00032506374,0.00039198628,0.00031841942,0.0002346796,0.00026181838,0.00055037654,0.00027692725,0.0013214207],"category_scores_gemma":[0.00014340256,0.00019197949,0.00023995806,0.00018668463,0.00018549334,0.00020806157,0.00016661336,0.0004048298,0.00032761492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005358204,0.0004520174,0.00024085946,0.00014781592,0.000032640146,0.00016578249,0.00007268836,0.0016932607,0.9816296,0.0008281634,0.00030232192,0.013899038],"study_design_scores_gemma":[0.00037813216,0.0056750216,0.0013835551,0.000019947032,0.000095893876,0.00034871002,0.000037899412,0.0015937224,0.9801641,0.00019087367,0.010093959,0.00001821987],"about_ca_topic_score_codex":0.0005364822,"about_ca_topic_score_gemma":0.001799066,"teacher_disagreement_score":0.0013214207,"about_ca_system_score_codex":0.00032249923,"about_ca_system_score_gemma":0.00030459178,"threshold_uncertainty_score":0.004420638},"labels":[],"label_agreement":null},{"id":"W2152702731","doi":"10.1016/s0960-894x(02)00633-9","title":"Benzodiazepine inhibitors of the MMPs and TACE","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Selectivity; Matrix metalloproteinase; Benzodiazepine; Pharmacology; Stereochemistry; Combinatorial chemistry; Biochemistry; Receptor","score_opus":0.005816392835052777,"score_gpt":0.17313183680089217,"score_spread":0.1673154439658394,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2152702731","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9360837,0.036346473,0.005474904,0.0015474402,0.00021318159,0.000117841926,0.000521758,0.00031612784,0.019378643],"genre_scores_gemma":[0.9781662,0.011595855,0.0011859916,0.00017135714,0.000053375297,0.00006374827,0.00032583647,0.0000100280795,0.008427527],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991655,0.0000143037505,0.000007031584,0.0000046048417,0.000019356663,0.00003824146],"domain_scores_gemma":[0.99993825,0.000013422052,0.000020961239,0.000005940898,0.0000067891456,0.000014657215],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013214853,0.0003201325,0.00021071041,0.00020402682,0.00012796254,0.00024615022,0.00019649958,0.00017941913,0.0019777874],"category_scores_gemma":[0.00020390157,0.00012242369,0.00016226133,0.00013216592,0.00015543094,0.000156703,0.00014861526,0.00051628385,0.00042938913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0029794003,0.00022963125,0.0006427258,0.00028997342,0.00007763152,0.0006952728,0.000084165404,0.001172461,0.9246144,0.0036708252,0.0023088325,0.06323464],"study_design_scores_gemma":[0.002244949,0.0049087494,0.012260953,0.000053719345,0.00014227809,0.003785299,0.00008966148,0.0031464447,0.9120366,0.0011842084,0.06010079,0.00004636372],"about_ca_topic_score_codex":0.0005349151,"about_ca_topic_score_gemma":0.0020248205,"teacher_disagreement_score":0.0019777874,"about_ca_system_score_codex":0.00027024176,"about_ca_system_score_gemma":0.00019754162,"threshold_uncertainty_score":0.0066164136},"labels":[],"label_agreement":null},{"id":"W2154052438","doi":"10.1016/j.bmcl.2004.05.082","title":"α,α-Difluoro-β-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"University of Toronto","keywords":"Chemistry; Protein tyrosine phosphatase; Alpha (finance); Aryl; Phosphatase; Stereochemistry; Tyrosine; Chemical synthesis; Enzyme inhibitor; BETA (programming language); Structure–activity relationship; Enzyme; In vitro; Biochemistry; Organic chemistry","score_opus":0.004635064813825663,"score_gpt":0.210794657012132,"score_spread":0.20615959219830632,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2154052438","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9508914,0.024172451,0.003884662,0.0004528704,0.0005164778,0.00012037094,0.00066620094,0.00029257292,0.019003112],"genre_scores_gemma":[0.97450215,0.016879559,0.0012234568,0.0001696933,0.000089596564,0.00005341806,0.00048266104,0.000022141012,0.0065773805],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998627,0.000025284147,0.000011736151,0.000015043095,0.000032697284,0.00005261604],"domain_scores_gemma":[0.99994195,0.000011126103,0.000011445352,0.0000040130285,0.000006105329,0.000025395917],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027278042,0.00055662636,0.00031995523,0.00037256134,0.00020468053,0.00027160638,0.00035084205,0.00029219265,0.0020101978],"category_scores_gemma":[0.00017795168,0.00022623065,0.00015197518,0.00025183352,0.00018946524,0.00026611963,0.0002323627,0.0005160295,0.00056501117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0031510587,0.0002941492,0.00033587546,0.00029200432,0.000037363257,0.0005255324,0.00007727936,0.0013174043,0.96488637,0.0017984344,0.0014492208,0.025835317],"study_design_scores_gemma":[0.0008500175,0.00353234,0.002058531,0.000029608882,0.0000760568,0.0012106257,0.00004566314,0.001354262,0.9708779,0.00028857737,0.019647576,0.00002902371],"about_ca_topic_score_codex":0.000837382,"about_ca_topic_score_gemma":0.001474982,"teacher_disagreement_score":0.0020101978,"about_ca_system_score_codex":0.0002363712,"about_ca_system_score_gemma":0.00025379172,"threshold_uncertainty_score":0.006724775},"labels":[],"label_agreement":null},{"id":"W2154867920","doi":"10.1016/j.bmcl.2005.08.001","title":"Synthesis and SAR of highly selective MMP-13 inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Sulfonamide; Matrix metalloproteinase; Aggrecanase; Selectivity; Stereochemistry; Chemical synthesis; Structure–activity relationship; Enzyme inhibitor; Combinatorial chemistry; Carboxamide; Pharmacology; Biochemistry; Enzyme; In vitro","score_opus":0.004667706794928407,"score_gpt":0.19869430143320901,"score_spread":0.19402659463828062,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2154867920","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87239397,0.027900517,0.063628934,0.0020203462,0.0004447967,0.0010428702,0.0036506548,0.00074353657,0.028174354],"genre_scores_gemma":[0.9291098,0.02644406,0.025549147,0.0004675734,0.0000879644,0.00031909955,0.0030168493,0.000057644964,0.014947916],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989307,0.000013474142,0.000009527964,0.000011046836,0.000030942196,0.0000418535],"domain_scores_gemma":[0.99994886,0.000007751814,0.000011229732,0.0000050046137,0.000009199242,0.00001802203],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026576238,0.00051841687,0.0003756056,0.00020320366,0.00020100281,0.00034848732,0.00041483206,0.00024436068,0.0015805712],"category_scores_gemma":[0.00018053252,0.0002705898,0.00022217707,0.0002214643,0.00016330673,0.00027527648,0.00023390175,0.0007435009,0.00067961623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00095783354,0.00044583855,0.00026357183,0.00044945703,0.000059497313,0.00069420965,0.0001374644,0.0070925937,0.9175253,0.0042830715,0.004463759,0.063627474],"study_design_scores_gemma":[0.00042812328,0.0015485655,0.0008337083,0.000032138836,0.000065068336,0.0007316716,0.000029614008,0.004001649,0.95154625,0.0006344896,0.040121578,0.000027116086],"about_ca_topic_score_codex":0.00056271313,"about_ca_topic_score_gemma":0.0015795646,"teacher_disagreement_score":0.0015805712,"about_ca_system_score_codex":0.0004783057,"about_ca_system_score_gemma":0.00048505364,"threshold_uncertainty_score":0.005287528},"labels":[],"label_agreement":null},{"id":"W2155026095","doi":"10.1016/j.bmcl.2005.10.082","title":"Phenolic P2/P3 core motif as thrombin inhibitors—Design, synthesis, and X-ray co-crystal structure","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; AstraZeneca","keywords":"Chemistry; Thrombin; Crystal structure; Stereochemistry; X-ray; Chemical synthesis; In vitro; Crystallography; Biochemistry","score_opus":0.019642948893228884,"score_gpt":0.25765990199926087,"score_spread":0.238016953106032,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2155026095","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96527463,0.008959864,0.013660664,0.00029328448,0.00008916582,0.00031989938,0.0010724219,0.00039247636,0.0099377],"genre_scores_gemma":[0.9729317,0.004150177,0.015367295,0.000121084886,0.000026922244,0.00010376614,0.0012582832,0.00004293043,0.0059978315],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999409,0.000011926085,0.000003825652,0.000012150617,0.000015048908,0.000016235213],"domain_scores_gemma":[0.99996114,0.000005179095,0.000007885001,0.0000042896177,0.0000056827284,0.0000157987],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016688238,0.0003114384,0.00033422315,0.00013843786,0.00018863802,0.00041927703,0.00053146307,0.0002684639,0.0015601476],"category_scores_gemma":[0.00014922187,0.00018372167,0.00020193604,0.0002431255,0.00012816294,0.00020593396,0.00015834076,0.00060352124,0.00063872826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019469262,0.00034961398,0.00059914443,0.000510363,0.00008061342,0.0006648746,0.00008798721,0.007012772,0.9337011,0.0022911732,0.0022221387,0.05053317],"study_design_scores_gemma":[0.0005512784,0.0016639293,0.0013281243,0.000029165989,0.00009957892,0.00087788,0.00004282256,0.011718824,0.95588946,0.00040474918,0.0273571,0.000037001497],"about_ca_topic_score_codex":0.0009767965,"about_ca_topic_score_gemma":0.0012167025,"teacher_disagreement_score":0.0015601476,"about_ca_system_score_codex":0.00032158336,"about_ca_system_score_gemma":0.00036223888,"threshold_uncertainty_score":0.005219221},"labels":[],"label_agreement":null},{"id":"W2157971107","doi":"10.1016/j.bmcl.2003.11.048","title":"The development of potent non-peptidic PTP-1B inhibitors","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Potency; Structure–activity relationship; Orally active; Peptide; Substituent; Pharmacology; In vivo; Chemical synthesis; Stereochemistry; Cyclic peptide; Diabetes mellitus; Insulin; Bioavailability; In vitro; Biochemistry; Internal medicine; Endocrinology; Medicine","score_opus":0.005303093696493836,"score_gpt":0.21147209077969079,"score_spread":0.20616899708319694,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2157971107","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7115476,0.16189241,0.09013472,0.0031926637,0.0012580287,0.0007159887,0.0015532922,0.0007613952,0.02894396],"genre_scores_gemma":[0.8911152,0.06843421,0.022380661,0.00081651006,0.00020402066,0.00032821984,0.0016932419,0.000043462456,0.014984478],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990356,0.000013429678,0.000006412555,0.000017928065,0.000031374242,0.000027314833],"domain_scores_gemma":[0.9999405,0.000010466255,0.000012536147,0.00000485467,0.000010727706,0.000020895981],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036515653,0.0004891728,0.0003932986,0.00021487052,0.00015535107,0.00051234604,0.00034709738,0.0003650916,0.0014243326],"category_scores_gemma":[0.00022587288,0.00024702717,0.00020668896,0.0001495756,0.00020380771,0.00039338015,0.00037808946,0.0011509872,0.0006272508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000793583,0.00049942324,0.00041044972,0.0007425399,0.000069288035,0.0004585479,0.00008063458,0.0034146656,0.83655816,0.008057409,0.0035921745,0.14532302],"study_design_scores_gemma":[0.0009033257,0.0032821007,0.001845973,0.00007457236,0.00012276227,0.0018421129,0.0000271991,0.00582733,0.877982,0.0016905727,0.10636396,0.000038023885],"about_ca_topic_score_codex":0.00019262363,"about_ca_topic_score_gemma":0.00065905286,"teacher_disagreement_score":0.0014243326,"about_ca_system_score_codex":0.00038410767,"about_ca_system_score_gemma":0.00025484432,"threshold_uncertainty_score":0.0047649145},"labels":[],"label_agreement":null},{"id":"W2158741231","doi":"10.1016/j.bmcl.2005.07.008","title":"ERβ ligands. Part 4: Synthesis and structure–activity relationships of a series of 2-phenylquinoline derivatives","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Agonist; Selectivity; Chemical synthesis; Partial agonist; Estrogen receptor; Structure–activity relationship; In vivo; Stereochemistry; Estrogen; Bioassay; Receptor; In vitro; Combinatorial chemistry; Biochemistry; Internal medicine","score_opus":0.008734000667717366,"score_gpt":0.20863202524313218,"score_spread":0.1998980245754148,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2158741231","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8651357,0.08197915,0.022181153,0.0010485151,0.0005563083,0.0010469034,0.0034239935,0.0006541147,0.0239741],"genre_scores_gemma":[0.91589427,0.040003985,0.010339881,0.0011075161,0.00016143959,0.0005834194,0.0033191026,0.000086287124,0.028504018],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990976,0.000022634957,0.000008579994,0.000015477724,0.000015920275,0.000027549826],"domain_scores_gemma":[0.9999393,0.000013909092,0.000012182355,0.000007477176,0.000013329419,0.000013817338],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027131548,0.00041954013,0.0003421716,0.0003462741,0.00016262347,0.0001541,0.00055980077,0.00023964459,0.0041358],"category_scores_gemma":[0.0001924384,0.00016758913,0.00033306182,0.00022522899,0.0001589404,0.00022112927,0.00018678648,0.00037840407,0.0010933637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012252231,0.0006346143,0.0002636774,0.0008907018,0.000057255453,0.00032717065,0.00017811419,0.0032005107,0.9276407,0.0011886782,0.0031907784,0.06120259],"study_design_scores_gemma":[0.0010861795,0.013581551,0.0038433822,0.000119302305,0.0001322999,0.0012882092,0.000073559546,0.001524957,0.8933397,0.0004683037,0.08446211,0.00008049511],"about_ca_topic_score_codex":0.0008672353,"about_ca_topic_score_gemma":0.0012352413,"teacher_disagreement_score":0.0041358,"about_ca_system_score_codex":0.00028295466,"about_ca_system_score_gemma":0.0002361599,"threshold_uncertainty_score":0.013835609},"labels":[],"label_agreement":null},{"id":"W2158791991","doi":"10.1016/j.bmcl.2009.10.049","title":"Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Trifluoromethyl; Stereochemistry; Kinase; Hydrogen bond; Amine gas treating; Aryl; Protein kinase A; Chemical synthesis; Structure–activity relationship; In vitro; Combinatorial chemistry; Biochemistry; Molecule; Organic chemistry","score_opus":0.006420254641340049,"score_gpt":0.2185084930702599,"score_spread":0.21208823842891986,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2158791991","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9577779,0.023779156,0.0046076854,0.0003703523,0.00019802095,0.00015806664,0.00066457025,0.00034512105,0.012099106],"genre_scores_gemma":[0.9850707,0.007923511,0.0016961591,0.000090514885,0.000026296106,0.00005326528,0.00041654878,0.000016845452,0.0047061983],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999143,0.000018903393,0.00000511083,0.000010479943,0.00002224494,0.000028926837],"domain_scores_gemma":[0.99995875,0.000008272072,0.000008280508,0.000004382121,0.0000053958715,0.00001496418],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023168398,0.00035969994,0.0003711131,0.0003100191,0.0002261804,0.0002957577,0.000483563,0.0002888776,0.0020687073],"category_scores_gemma":[0.00012947863,0.00019452117,0.00017593185,0.00021850587,0.00017609213,0.00028400653,0.00028895857,0.0005494352,0.0004346419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00205451,0.00045595356,0.00040238164,0.0005260142,0.000038356964,0.00052843237,0.00012378392,0.0038129205,0.9336924,0.0029588046,0.0020495167,0.05335689],"study_design_scores_gemma":[0.0019319892,0.010847972,0.0076220315,0.000083946674,0.0001438171,0.0023695843,0.000095432064,0.009469538,0.9157034,0.0013047445,0.050322313,0.00010515031],"about_ca_topic_score_codex":0.000689373,"about_ca_topic_score_gemma":0.0028292171,"teacher_disagreement_score":0.0020687073,"about_ca_system_score_codex":0.00037349234,"about_ca_system_score_gemma":0.00022452167,"threshold_uncertainty_score":0.006920457},"labels":[],"label_agreement":null},{"id":"W2159117830","doi":"10.1016/j.bmcl.2003.11.023","title":"3-(2-Pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT1B/1D ligands","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Nuvo Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Indole test; Stereochemistry; In vitro; Biochemistry","score_opus":0.015332859721993665,"score_gpt":0.27054568643785637,"score_spread":0.2552128267158627,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2159117830","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9509852,0.028988453,0.006319922,0.0003812062,0.00018618903,0.00012567641,0.00081005966,0.00028724218,0.01191612],"genre_scores_gemma":[0.98051065,0.0072556296,0.0036293666,0.00017347102,0.00005119272,0.00008150638,0.0008402173,0.000028330896,0.007429668],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983585,0.00006323735,0.0000058425753,0.000014377305,0.000025347397,0.00005524904],"domain_scores_gemma":[0.9999424,0.00002030669,0.000008389349,0.000005225435,0.0000057870416,0.000017827011],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024398517,0.00024384889,0.00040548778,0.00021868407,0.0002386377,0.00022648016,0.00054689957,0.00031641067,0.0031967394],"category_scores_gemma":[0.00016641045,0.00019421168,0.00014307407,0.00021654385,0.00015281205,0.0002149113,0.00019867838,0.0004955024,0.0009266223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002252611,0.00030776171,0.0003998595,0.00038832665,0.000041342853,0.0003148219,0.00015920441,0.0009090715,0.97094643,0.0012447255,0.0015760922,0.021459771],"study_design_scores_gemma":[0.0009379922,0.006663361,0.0061857007,0.00005419741,0.00013351973,0.0015216611,0.00013462444,0.0033166697,0.95072556,0.00020874818,0.030065926,0.000052057658],"about_ca_topic_score_codex":0.0011061534,"about_ca_topic_score_gemma":0.0036135125,"teacher_disagreement_score":0.0031967394,"about_ca_system_score_codex":0.00034251052,"about_ca_system_score_gemma":0.00014912373,"threshold_uncertainty_score":0.010694206},"labels":[],"label_agreement":null},{"id":"W2160227358","doi":"10.1016/j.bmcl.2007.01.002","title":"New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre de Recherche Industrielle du Québec","funders":"","keywords":"Chemistry; Morpholine; Kinase; Tyrosine kinase; Biochemistry; Receptor tyrosine kinase; Tyrosine-kinase inhibitor; Cancer research; Signal transduction; Cancer","score_opus":0.017555498955955266,"score_gpt":0.2870311224545731,"score_spread":0.2694756234986178,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2160227358","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94337475,0.016551025,0.014600874,0.00056956394,0.00030682154,0.00026648527,0.00071120204,0.0007296163,0.022889663],"genre_scores_gemma":[0.9806645,0.0051175635,0.0040332237,0.00024886773,0.00006484911,0.00010652322,0.00056306116,0.00003078132,0.0091705015],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989486,0.000013024299,0.000006665726,0.000012971196,0.00001843489,0.000053976393],"domain_scores_gemma":[0.9999603,0.0000050406725,0.000011444711,0.000003016377,0.000004339914,0.000015959024],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791265,0.00051802985,0.0004997177,0.00027473507,0.00023596139,0.00026845007,0.0005607642,0.0003147577,0.002978895],"category_scores_gemma":[0.00009927922,0.00020538198,0.0002520413,0.00022088797,0.00017716477,0.00034548732,0.00028990066,0.0007388083,0.00050348986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019509133,0.00032067703,0.0003442808,0.0004701239,0.000065954366,0.0010311059,0.00016107594,0.0016231652,0.9292618,0.0035939293,0.002107365,0.05906976],"study_design_scores_gemma":[0.0014275135,0.007334754,0.005467756,0.000075744465,0.00019638488,0.0045365854,0.00008347941,0.008103825,0.9168492,0.0006311819,0.055213034,0.00008049956],"about_ca_topic_score_codex":0.0006324035,"about_ca_topic_score_gemma":0.00211437,"teacher_disagreement_score":0.002978895,"about_ca_system_score_codex":0.0004641221,"about_ca_system_score_gemma":0.00022862261,"threshold_uncertainty_score":0.00996536},"labels":[],"label_agreement":null},{"id":"W2160679484","doi":"10.1016/s0960-894x(02)00190-7","title":"Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Orally active; Pharmacology; Enzyme inhibitor; Phosphodiesterase; cGMP-specific phosphodiesterase type 5; In vitro; Enzyme; Biochemistry; Sildenafil; Internal medicine; Medicine","score_opus":0.006689069541076854,"score_gpt":0.19671551328509923,"score_spread":0.1900264437440224,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2160679484","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96104926,0.009201293,0.012069084,0.0018663588,0.00020599432,0.00032398835,0.0015671962,0.00045536124,0.01326132],"genre_scores_gemma":[0.9732284,0.0070667965,0.0057216515,0.00059810054,0.000081587976,0.000121359546,0.0020687787,0.000062194355,0.011051093],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999348,0.000007734499,0.0000036620515,0.000009820995,0.00001603428,0.000027914086],"domain_scores_gemma":[0.9999579,0.000006457151,0.000008218328,0.0000029123041,0.000005944506,0.000018479937],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021143672,0.00049777684,0.00048096952,0.0002856138,0.00017661323,0.0004779698,0.0005171041,0.000447563,0.0014562613],"category_scores_gemma":[0.00018320353,0.00020326157,0.00025768043,0.00018518725,0.00025017292,0.00028765184,0.00022588365,0.00088474253,0.0007480262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015302324,0.00045721454,0.00065724185,0.00021044076,0.00005754788,0.0011904528,0.000055744025,0.001219729,0.9410095,0.0018642873,0.0026672941,0.049080286],"study_design_scores_gemma":[0.0021520674,0.0048719677,0.005170975,0.000030752824,0.00020212645,0.004524699,0.00004227296,0.0036313592,0.9456816,0.00065241376,0.032998014,0.000041629766],"about_ca_topic_score_codex":0.0007236163,"about_ca_topic_score_gemma":0.0013063692,"teacher_disagreement_score":0.0014562613,"about_ca_system_score_codex":0.0005228252,"about_ca_system_score_gemma":0.0005636968,"threshold_uncertainty_score":0.0048716664},"labels":[],"label_agreement":null},{"id":"W2162321649","doi":"10.1016/j.bmcl.2015.11.022","title":"Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Treventis (Canada); University Health Network; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Edaravone; Palladium; Aryl; Combinatorial chemistry; Amyloid beta; Context (archaeology); Small molecule; Drug discovery; Catalysis; Peptide; Pharmacology; Biochemistry; Organic chemistry","score_opus":0.028456441879328716,"score_gpt":0.2874712783756035,"score_spread":0.25901483649627477,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2162321649","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9715323,0.0044704033,0.01757663,0.0003048521,0.0000971508,0.00012288346,0.00022234645,0.0002608354,0.0054125446],"genre_scores_gemma":[0.99197185,0.0024475942,0.0033195978,0.000106146814,0.000008516671,0.00002227168,0.00011439649,0.00002058162,0.0019890112],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993265,0.000008663846,0.0000043265413,0.000017415954,0.000009470904,0.000027510969],"domain_scores_gemma":[0.9999666,0.000004932119,0.000009408675,0.000005519956,0.0000059056483,0.0000075084645],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019245729,0.0005091905,0.00023593978,0.00017017314,0.00013031757,0.0001954051,0.00040790078,0.00040080666,0.00081542303],"category_scores_gemma":[0.0001154319,0.00017675324,0.00031413173,0.00018232157,0.00023557362,0.00034559108,0.0003469298,0.0005235024,0.00024479418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022923047,0.000052796517,0.000092669965,0.00012184375,0.000028618239,0.00030942322,0.00005733878,0.0004330016,0.9911848,0.000500087,0.00014314907,0.006847034],"study_design_scores_gemma":[0.0000348704,0.00038942968,0.00039435906,0.0000051911943,0.000026905956,0.00033084938,0.000018797184,0.00042891613,0.99536645,0.00010993224,0.0028852709,0.00000895704],"about_ca_topic_score_codex":0.0005305262,"about_ca_topic_score_gemma":0.00073686586,"teacher_disagreement_score":0.00081542303,"about_ca_system_score_codex":0.0002064715,"about_ca_system_score_gemma":0.00017275728,"threshold_uncertainty_score":0.0027278662},"labels":[],"label_agreement":null},{"id":"W2163220130","doi":"10.1016/s0960-894x(01)00253-0","title":"5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Chemistry; Reuptake; Transporter; Glycine; Reuptake inhibitor; Pharmacology; Stereochemistry; Amino acid; Biochemistry; Receptor; Gene; Serotonin; Biology","score_opus":0.0304216858102352,"score_gpt":0.28527362719292193,"score_spread":0.25485194138268674,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2163220130","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9271681,0.025974218,0.010530439,0.00064851844,0.0005515711,0.00029125385,0.0011480156,0.0006502664,0.03303761],"genre_scores_gemma":[0.9630823,0.014865123,0.0045458195,0.00045223115,0.000080980164,0.00012320251,0.00082600786,0.00004913363,0.015975105],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991834,0.000017843488,0.00000632812,0.000012515944,0.000015957381,0.000029037872],"domain_scores_gemma":[0.9999747,0.000003170523,0.000005440053,0.0000026806144,0.0000030041706,0.00001100813],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016087912,0.0003969224,0.00048694995,0.00018620749,0.00016930934,0.00030426355,0.00035646427,0.00031243017,0.0023003116],"category_scores_gemma":[0.0000853247,0.00019555737,0.00016313443,0.00014596205,0.00014410025,0.00033975026,0.00022284515,0.000507043,0.0008746206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015445924,0.00031496675,0.00025089388,0.00040709303,0.00004148477,0.0007100572,0.00011810296,0.0015503295,0.9450176,0.0030858796,0.0022067884,0.044752337],"study_design_scores_gemma":[0.0012832321,0.010390533,0.0073931273,0.0001053757,0.0001580892,0.0035066027,0.00011464121,0.006910546,0.905555,0.0009736708,0.0635043,0.00010492875],"about_ca_topic_score_codex":0.00048406475,"about_ca_topic_score_gemma":0.002368907,"teacher_disagreement_score":0.0023003116,"about_ca_system_score_codex":0.00029299746,"about_ca_system_score_gemma":0.00019174881,"threshold_uncertainty_score":0.0076953173},"labels":[],"label_agreement":null},{"id":"W2163493945","doi":"10.1016/j.bmcl.2006.08.102","title":"Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Quinoline; Kinase; Rheumatoid arthritis; Pharmacology; Enzyme; Enzyme inhibitor; Arthritis; Biochemistry; Immunology; Medicine","score_opus":0.006783218721431135,"score_gpt":0.19751929579741528,"score_spread":0.19073607707598414,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2163493945","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96787226,0.02506351,0.002883035,0.0005811216,0.00021420412,0.000115004754,0.0003102627,0.00020253842,0.0027579379],"genre_scores_gemma":[0.99187547,0.0053766565,0.0008059084,0.00007876773,0.000046424284,0.000056141467,0.00018834767,0.000010207802,0.0015621132],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999025,0.00002653141,0.000007811379,0.000008278701,0.000018935032,0.00003585467],"domain_scores_gemma":[0.9999528,0.0000089582145,0.000012563865,0.0000045551715,0.0000053639674,0.00001576236],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021861216,0.0003884477,0.0004080614,0.00027401044,0.00020552831,0.00020926504,0.00032218607,0.00032004982,0.0012646309],"category_scores_gemma":[0.00012933895,0.00013804594,0.00026881942,0.00019531586,0.00022270155,0.00014839577,0.00012650642,0.000708577,0.00025454853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.006186167,0.00042797622,0.00019050155,0.00023870151,0.00005746313,0.0004757795,0.000045262717,0.00061010313,0.9672915,0.00034168537,0.0006591624,0.023475816],"study_design_scores_gemma":[0.0026857257,0.0087091485,0.003444617,0.00003095582,0.00012967711,0.0009675199,0.00004469139,0.0014090856,0.974026,0.00017436137,0.008342106,0.00003609657],"about_ca_topic_score_codex":0.00094465195,"about_ca_topic_score_gemma":0.002276998,"teacher_disagreement_score":0.0012646309,"about_ca_system_score_codex":0.00023113261,"about_ca_system_score_gemma":0.00030331186,"threshold_uncertainty_score":0.0042306185},"labels":[],"label_agreement":null},{"id":"W2164023349","doi":"10.1016/j.bmcl.2004.03.032","title":"Synthesis and biological activity of some structural modifications of pancratistatin","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":84,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"National Cancer Institute; National Science Foundation","keywords":"Chemistry; Chemical synthesis; Biological activity; Structure–activity relationship; Stereochemistry; Combinatorial chemistry; Biochemistry; In vitro","score_opus":0.017044226325938376,"score_gpt":0.22951703567509302,"score_spread":0.21247280934915463,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2164023349","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9854048,0.003166391,0.0038098474,0.00015863385,0.000077424396,0.00009676712,0.00059279084,0.000077514684,0.006615864],"genre_scores_gemma":[0.99223775,0.0015037701,0.0026633798,0.0000882452,0.000024119929,0.000024042694,0.00047992388,0.000023739869,0.0029550677],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999187,0.000012455461,0.000009571012,0.000018488698,0.000016499544,0.000024355786],"domain_scores_gemma":[0.9999269,0.000007259018,0.000022789565,0.000013736889,0.000012984064,0.000016302803],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009775967,0.0003195181,0.00018827882,0.00014147568,0.00016190803,0.00013969107,0.0002754256,0.00023421017,0.0013979491],"category_scores_gemma":[0.00011928456,0.00011623302,0.00026012864,0.00015295681,0.00015175277,0.00022524038,0.00013765504,0.00039017253,0.00033832132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022469005,0.00002920276,0.000071089074,0.00004916421,0.000006738083,0.00013853544,0.000019286079,0.0002519877,0.995783,0.0001247921,0.000039775754,0.0032618155],"study_design_scores_gemma":[0.000031022853,0.00078221544,0.0010258569,0.0000030488648,0.00002139496,0.0002652052,0.00000878752,0.00021621998,0.99406636,0.000039544087,0.0035337007,0.0000065060003],"about_ca_topic_score_codex":0.00060815795,"about_ca_topic_score_gemma":0.0007620186,"teacher_disagreement_score":0.0013979491,"about_ca_system_score_codex":0.00019340616,"about_ca_system_score_gemma":0.00017692774,"threshold_uncertainty_score":0.0046765804},"labels":[],"label_agreement":null},{"id":"W2164590798","doi":"10.1016/j.bmcl.2006.12.005","title":"Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"DNA gyrase; Chemistry; Topoisomerase; Topoisomerase IV; Stereochemistry; Enzyme; Antibacterial activity; DNA; Structure–activity relationship; Antibacterial agent; Potency; IC50; Enzyme inhibitor; Escherichia coli; Biochemistry; Bacteria; In vitro; Antibiotics; Genetics; Gene; Biology","score_opus":0.009390209359496289,"score_gpt":0.21314797752573925,"score_spread":0.20375776816624297,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2164590798","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9854224,0.011347652,0.0011363864,0.00011454056,0.000032487253,0.000030953852,0.00030554,0.00006614751,0.0015437832],"genre_scores_gemma":[0.99541795,0.0024323072,0.00063947967,0.00004786262,0.000012655859,0.000011174692,0.00045795875,0.0000056190675,0.00097501976],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998815,0.000036054098,0.000008957934,0.000016692364,0.00003120966,0.000025610203],"domain_scores_gemma":[0.9998697,0.000035427347,0.000031083113,0.0000067886417,0.000023353645,0.00003360623],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002812556,0.00023822917,0.00026881913,0.0001812077,0.000070711045,0.00022278438,0.00024927317,0.00021502751,0.0008647071],"category_scores_gemma":[0.00026696664,0.00012288509,0.00018115864,0.00009604561,0.00011907762,0.00014062646,0.00007422211,0.0002731872,0.00018504586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002343494,0.00027177526,0.0014056552,0.00011517603,0.00005993934,0.000186131,0.000052576514,0.0035699732,0.9768817,0.00029672933,0.00046598678,0.014350795],"study_design_scores_gemma":[0.00091124553,0.015242811,0.0146081755,0.000026123598,0.00019954833,0.0013763388,0.00004179507,0.011338092,0.94458944,0.0001635176,0.011447666,0.00005530809],"about_ca_topic_score_codex":0.00095934194,"about_ca_topic_score_gemma":0.0016774207,"teacher_disagreement_score":0.00095934194,"about_ca_system_score_codex":0.0002858475,"about_ca_system_score_gemma":0.00011953769,"threshold_uncertainty_score":0.0028927326},"labels":[],"label_agreement":null},{"id":"W2165218854","doi":"10.1016/j.bmcl.2004.10.050","title":"Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Isozyme; Cyclooxygenase; Selectivity; Stereochemistry; Enzyme inhibitor; Sulfone; Enzyme; Biochemistry; Organic chemistry; Catalysis","score_opus":0.009636012628210308,"score_gpt":0.20707634541775602,"score_spread":0.1974403327895457,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2165218854","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8729482,0.012733156,0.09734795,0.00095552736,0.0003537472,0.0007920354,0.0009976756,0.00043053078,0.013441148],"genre_scores_gemma":[0.94072556,0.00980264,0.036734372,0.0003081988,0.0000757195,0.0002805029,0.00092521874,0.000058406793,0.011089339],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991345,0.000011599256,0.000009334427,0.00001799007,0.000020891051,0.000026829272],"domain_scores_gemma":[0.99994516,0.000005735564,0.000015515086,0.000005368574,0.000010674596,0.000017519924],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025732274,0.00036759622,0.00026977065,0.00022576177,0.00014529012,0.00030900372,0.0004942274,0.00037303704,0.0018189291],"category_scores_gemma":[0.00015325914,0.00024350178,0.0002564244,0.00018822248,0.00016450044,0.00048447945,0.0002814273,0.0006076318,0.0006532653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039071016,0.00029411458,0.00013966345,0.00022075376,0.0000314678,0.00035171813,0.00009584575,0.0020031983,0.96848774,0.0031576888,0.0005846147,0.024242353],"study_design_scores_gemma":[0.00026622482,0.0013486749,0.0004449842,0.0000159642,0.000041051513,0.00044183937,0.000024992616,0.002024675,0.97595644,0.00044570855,0.018968765,0.000020748792],"about_ca_topic_score_codex":0.0002037053,"about_ca_topic_score_gemma":0.00064836117,"teacher_disagreement_score":0.0018189291,"about_ca_system_score_codex":0.0002476606,"about_ca_system_score_gemma":0.00030787484,"threshold_uncertainty_score":0.006084919},"labels":[],"label_agreement":null},{"id":"W2166459466","doi":"10.1016/j.bmcl.2008.11.118","title":"Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"","keywords":"Thalidomide; Angiogenesis; Chemistry; In vivo; In vitro; Multiple sclerosis; Pharmacology; Cell culture; Cancer research; Biochemistry; Immunology; Multiple myeloma; Medicine; Biology","score_opus":0.12927677899697254,"score_gpt":0.32602847978575317,"score_spread":0.19675170078878063,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2166459466","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98638666,0.00853667,0.0012468112,0.000105911255,0.00003609082,0.00022236386,0.00039064555,0.00002485494,0.0030499373],"genre_scores_gemma":[0.9938753,0.0027818496,0.0012551441,0.000058550286,0.000021164837,0.000052707197,0.0006165032,0.000008387833,0.0013304524],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998192,0.000080374346,0.000012616923,0.000016760327,0.000029696084,0.000041331048],"domain_scores_gemma":[0.99980575,0.000084456326,0.000020162553,0.000016043838,0.000034251472,0.000039418654],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005291591,0.00023410145,0.00032572635,0.00020535711,0.00023645259,0.00029822334,0.00030317824,0.00027173848,0.001942255],"category_scores_gemma":[0.00046827339,0.00012313551,0.00028576358,0.00019553538,0.00021307316,0.0001789254,0.00011489009,0.0004030541,0.00023550064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0050120484,0.0007617665,0.0005222171,0.0003220141,0.000071801456,0.00027620868,0.00015127152,0.0020756647,0.97548544,0.00023143935,0.00032031542,0.014769886],"study_design_scores_gemma":[0.0007274917,0.0341576,0.0038552762,0.000023083725,0.00016679191,0.0005889166,0.0000695436,0.0012201036,0.951794,0.0000941626,0.007282879,0.000020018608],"about_ca_topic_score_codex":0.0013491297,"about_ca_topic_score_gemma":0.0013345432,"teacher_disagreement_score":0.001942255,"about_ca_system_score_codex":0.00020974585,"about_ca_system_score_gemma":0.00020226576,"threshold_uncertainty_score":0.0064974427},"labels":[],"label_agreement":null},{"id":"W2167599523","doi":"10.1016/j.bmcl.2003.09.071","title":"Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Antibiotics; Bacteria; Drug; Pharmacology; Antibacterial agent; Drug resistance; Stereochemistry; Combinatorial chemistry; Microbiology; Biochemistry; Medicine","score_opus":0.007022257467801174,"score_gpt":0.21233662592984004,"score_spread":0.20531436846203888,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2167599523","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91203374,0.06335765,0.0040447866,0.00078337017,0.0004818544,0.00023917975,0.00043707964,0.0002268581,0.018395446],"genre_scores_gemma":[0.9553235,0.030685525,0.0026966725,0.00026458374,0.00018819372,0.00007892854,0.0003728507,0.00004008198,0.010349664],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998969,0.00002075236,0.000009562884,0.000010354281,0.00003585252,0.000026586682],"domain_scores_gemma":[0.999912,0.00001473117,0.000021367927,0.000006002069,0.000011098608,0.000034763903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024611832,0.00033901838,0.00031427882,0.00024042271,0.0001471955,0.0002281418,0.0002940634,0.00022895419,0.0010441233],"category_scores_gemma":[0.00025939706,0.00018228298,0.00011124658,0.0001851018,0.00024107643,0.00036918468,0.00031945383,0.0004743293,0.0002811827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0026858842,0.00016036298,0.00036929993,0.00054367405,0.00002924337,0.00034752372,0.000076682285,0.00085016584,0.9244448,0.0037274028,0.0017608632,0.06500419],"study_design_scores_gemma":[0.0005016229,0.002809207,0.0019921267,0.00002801889,0.000039126477,0.00068519934,0.000035908448,0.0006647091,0.9452727,0.00037001044,0.047573887,0.0000275016],"about_ca_topic_score_codex":0.00065117574,"about_ca_topic_score_gemma":0.0011465946,"teacher_disagreement_score":0.0010441233,"about_ca_system_score_codex":0.00019239179,"about_ca_system_score_gemma":0.00021994625,"threshold_uncertainty_score":0.0034929514},"labels":[],"label_agreement":null},{"id":"W2168361625","doi":"10.1016/j.bmcl.2014.05.021","title":"Synthesis and evaluation of 18F-labeled tertiary benzenesulfonamides for imaging carbonic anhydrase IX expression in tumours with positron emission tomography","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Positron emission tomography; In vivo; Carbonic anhydrase; Ex vivo; Enzyme; In vitro; Biochemistry; Nuclear medicine; Medicine","score_opus":0.005377274377020196,"score_gpt":0.21970227822257513,"score_spread":0.21432500384555492,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2168361625","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9554589,0.005381007,0.029625483,0.0002921376,0.00008224873,0.00064215815,0.0009019169,0.00023682696,0.0073792953],"genre_scores_gemma":[0.97619903,0.0033662787,0.015069604,0.000076109,0.000023279103,0.00019405849,0.00093368423,0.00007011823,0.0040679127],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983215,0.000045615707,0.000013769188,0.000023629327,0.00003450213,0.00005034975],"domain_scores_gemma":[0.9998154,0.00002904621,0.00004447108,0.000023600938,0.000040223735,0.000047341833],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054970704,0.00049404346,0.00039991265,0.000256991,0.00022352012,0.00027269198,0.00051211874,0.00049104315,0.0012041384],"category_scores_gemma":[0.00038712737,0.0002613338,0.00027813012,0.00027984148,0.00022333054,0.00029529308,0.00019855058,0.00040435925,0.00054112606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048771908,0.00012049006,0.00020957581,0.00016956354,0.000026221483,0.00031128703,0.000111512054,0.0018586876,0.9877868,0.00081569306,0.0002778842,0.007824442],"study_design_scores_gemma":[0.00008519599,0.0010890034,0.0005864145,0.000008217034,0.000030505946,0.00025596545,0.000016714954,0.0011695239,0.9914743,0.00004491282,0.005226411,0.000012879438],"about_ca_topic_score_codex":0.0017917645,"about_ca_topic_score_gemma":0.0025512485,"teacher_disagreement_score":0.0017917645,"about_ca_system_score_codex":0.000751764,"about_ca_system_score_gemma":0.0005375625,"threshold_uncertainty_score":0.0054544806},"labels":[],"label_agreement":null},{"id":"W2168587099","doi":"10.1016/s0960-894x(02)00608-x","title":"Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 2: Arylethanolaminomethylpiperidines","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Pharmacophore; Chemistry; Agonist; In vivo; Chemical synthesis; Structure–activity relationship; Stereochemistry; Pharmacology; Biological activity; Combinatorial chemistry; In vitro; Receptor; Biochemistry","score_opus":0.017267014079157896,"score_gpt":0.22308789373610444,"score_spread":0.20582087965694654,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2168587099","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94824654,0.022809409,0.011078002,0.0006696907,0.00033346517,0.00029060617,0.0011253962,0.0004222325,0.015024578],"genre_scores_gemma":[0.9603867,0.019700946,0.006576901,0.0004989683,0.00012704854,0.00026711568,0.0010319949,0.00004235236,0.011367822],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992394,0.000016240605,0.000007766021,0.00001177838,0.00001256064,0.00002770752],"domain_scores_gemma":[0.999962,0.000008583093,0.000011104034,0.000004425519,0.0000036396136,0.00001027399],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021551951,0.0004942846,0.00037373774,0.00017245198,0.00013293617,0.00021864884,0.0005215525,0.0003755064,0.0029741274],"category_scores_gemma":[0.00015745757,0.00022585133,0.00020068148,0.00018530559,0.00016446578,0.00029460917,0.000259334,0.0006056504,0.00087821897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016270363,0.00019159932,0.00018974167,0.00037293558,0.000041926098,0.00073201203,0.00011681777,0.0010014903,0.94992673,0.0012871942,0.001431973,0.043080598],"study_design_scores_gemma":[0.0012141521,0.0070410674,0.003645128,0.000049814207,0.00017052786,0.0028527132,0.000060055605,0.0017351072,0.93103915,0.00047269298,0.05165443,0.00006519851],"about_ca_topic_score_codex":0.00027999122,"about_ca_topic_score_gemma":0.0007987227,"teacher_disagreement_score":0.0029741274,"about_ca_system_score_codex":0.00022944981,"about_ca_system_score_gemma":0.00016151191,"threshold_uncertainty_score":0.009949446},"labels":[],"label_agreement":null},{"id":"W2168737922","doi":"10.1016/j.bmcl.2004.12.029","title":"2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute","funders":"Korea Science and Engineering Foundation","keywords":"Chemistry; Glycation; Stereochemistry; Quinone; Lipid peroxidation; Biochemistry; Antioxidant","score_opus":0.008956974148998348,"score_gpt":0.25882193250912616,"score_spread":0.24986495836012781,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2168737922","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9600816,0.020328315,0.011395358,0.00055850303,0.00025217264,0.00012307415,0.00033219592,0.00039254673,0.006536422],"genre_scores_gemma":[0.9884093,0.0043340493,0.002622075,0.00012653005,0.00007762419,0.00006143953,0.00029245042,0.000022778873,0.0040536462],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999892,0.000026030903,0.0000065305926,0.000013359737,0.0000228688,0.000039155202],"domain_scores_gemma":[0.9998838,0.000028583558,0.00002689467,0.000013070392,0.000017177428,0.000030452848],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002976819,0.00038760024,0.00029830806,0.00023410525,0.0001811013,0.00017896618,0.00042520088,0.000361932,0.0016570708],"category_scores_gemma":[0.00021148109,0.00021947866,0.00022687046,0.00011982186,0.00023342767,0.00037071813,0.00020334378,0.0004457327,0.0004748699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008260385,0.000118015254,0.00013943389,0.00009182583,0.000014187399,0.00013200492,0.000050689378,0.00033220704,0.98962224,0.0009841538,0.00037491438,0.0073142806],"study_design_scores_gemma":[0.00013417362,0.0018943832,0.0016183842,0.000009122674,0.000025173094,0.00034329848,0.000016785505,0.0008992803,0.986636,0.00021810996,0.00819286,0.000012462132],"about_ca_topic_score_codex":0.0003063041,"about_ca_topic_score_gemma":0.00043605457,"teacher_disagreement_score":0.0016570708,"about_ca_system_score_codex":0.00021480682,"about_ca_system_score_gemma":0.00018222025,"threshold_uncertainty_score":0.0055434704},"labels":[],"label_agreement":null},{"id":"W2169784480","doi":"10.1016/s0960-894x(03)00161-6","title":"Identification of a broad-Spectrum azasordarin with improved pharmacokinetic properties","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Pharmacokinetics; Broad spectrum; Antifungal; Stereochemistry; Derivative (finance); Combinatorial chemistry; Identification (biology); Pharmacology; Microbiology","score_opus":0.00889453861317837,"score_gpt":0.19419928882640508,"score_spread":0.1853047502132267,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2169784480","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9893316,0.0028901321,0.0038976585,0.00040441376,0.000054197546,0.00015506157,0.00038010583,0.00011087342,0.002775862],"genre_scores_gemma":[0.99172467,0.00110872,0.0043239193,0.00021933693,0.00003587673,0.00004166547,0.0009017805,0.000021786209,0.0016223583],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986005,0.00003111508,0.000012648908,0.000026832751,0.000027041475,0.00004227814],"domain_scores_gemma":[0.9999057,0.00001989573,0.000012124238,0.000015871185,0.000019610712,0.000026654014],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003066784,0.0004135871,0.00065154914,0.0002917303,0.00021269926,0.00047576835,0.00039980607,0.00043001055,0.0013290416],"category_scores_gemma":[0.00034545735,0.0001432693,0.00032460107,0.00019844306,0.00025996898,0.0003366285,0.00026605494,0.00064042927,0.00045696404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009263357,0.00022828815,0.00092484354,0.000048035876,0.000032508153,0.00051079405,0.000037424365,0.00033591661,0.9804985,0.00030267128,0.00023822962,0.015916426],"study_design_scores_gemma":[0.0005034891,0.005418118,0.008475504,0.000010550962,0.00019332347,0.0044131046,0.000051235886,0.0022613748,0.9701302,0.00025472842,0.008263318,0.000025015328],"about_ca_topic_score_codex":0.00044611268,"about_ca_topic_score_gemma":0.000760559,"teacher_disagreement_score":0.0013290416,"about_ca_system_score_codex":0.00038846844,"about_ca_system_score_gemma":0.00040408855,"threshold_uncertainty_score":0.0044460893},"labels":[],"label_agreement":null},{"id":"W2170520945","doi":"10.1016/j.bmcl.2005.01.050","title":"Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke; Institut National de la Recherche Scientifique","funders":"","keywords":"Human cytomegalovirus; Chemistry; Stereochemistry; Chemical synthesis; In vitro; Cytomegalovirus; Combinatorial chemistry; Herpesviridae; Biochemistry; Virology; Virus; Viral disease; Gene; Biology","score_opus":0.02015203218540299,"score_gpt":0.2745062861545051,"score_spread":0.2543542539691021,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2170520945","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9076925,0.01553226,0.050547868,0.00052869995,0.00030830107,0.0011172236,0.001662384,0.0005864349,0.022024292],"genre_scores_gemma":[0.9490986,0.010178577,0.027470965,0.00024687377,0.00006159431,0.00039407526,0.0014909948,0.000056687797,0.011001799],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999931,0.000010409535,0.000007736035,0.0000148751515,0.00001674718,0.000019281384],"domain_scores_gemma":[0.9999591,0.0000048402167,0.0000111552035,0.0000045269812,0.000007337946,0.000012888523],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617084,0.00039954318,0.0003145684,0.00019461782,0.00018917046,0.00024593394,0.0004907189,0.00023358974,0.001703072],"category_scores_gemma":[0.00013330797,0.00020085972,0.00019250445,0.00013008961,0.00011921668,0.00022170327,0.00022401297,0.00036902894,0.0005821951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002442504,0.00010478203,0.00012625885,0.00028778083,0.000025390718,0.00033293437,0.00009068311,0.002322196,0.97380507,0.0013532054,0.0005608635,0.020746587],"study_design_scores_gemma":[0.00018134461,0.002398501,0.0009903685,0.00003318335,0.00005761754,0.0005544429,0.000027152459,0.002785736,0.95616245,0.00025426535,0.03652882,0.000026174746],"about_ca_topic_score_codex":0.00042168365,"about_ca_topic_score_gemma":0.0014292833,"teacher_disagreement_score":0.001703072,"about_ca_system_score_codex":0.00026155115,"about_ca_system_score_gemma":0.00022680212,"threshold_uncertainty_score":0.0056973696},"labels":[],"label_agreement":null},{"id":"W2171505728","doi":"10.1016/j.bmcl.2005.01.053","title":"Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Diazepine; Chemistry; In vivo; In vitro; Hydroxamic acid; Arthritis; Biological activity; Pharmacology; Matrix metalloproteinase; Ring (chemistry); Stereochemistry; Enzyme inhibitor; Chemical synthesis; Structure–activity relationship; Biochemistry; Combinatorial chemistry; Internal medicine; Organic chemistry","score_opus":0.004367511705403056,"score_gpt":0.19640960189335496,"score_spread":0.1920420901879519,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2171505728","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8592601,0.024413427,0.050123107,0.001953824,0.0004423184,0.0010042284,0.0030317744,0.00046739142,0.059303824],"genre_scores_gemma":[0.9446785,0.017473843,0.016241753,0.0003297679,0.00009185987,0.00023422814,0.0017879423,0.00002622754,0.019135948],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999511,0.000008402618,0.0000047823555,0.0000060846914,0.000012049884,0.000017594588],"domain_scores_gemma":[0.99996996,0.000004689712,0.000006464586,0.0000032052662,0.000005307455,0.000010332576],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015120507,0.0002716522,0.00023626845,0.00018960601,0.0001631651,0.00020109868,0.00036047265,0.00018238748,0.0021146666],"category_scores_gemma":[0.0001271149,0.00018208096,0.0001534867,0.00016443113,0.00014349488,0.00024617792,0.00018424795,0.00044725,0.00080188946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011050054,0.000371857,0.00032464595,0.00069959875,0.000054098786,0.0019295488,0.00023793797,0.0071739415,0.90494037,0.0075391727,0.003950297,0.07167368],"study_design_scores_gemma":[0.00072209595,0.003632799,0.002726819,0.000069001515,0.000104063954,0.0022847787,0.00008914612,0.0068195965,0.8829757,0.0017198989,0.09880324,0.000052954107],"about_ca_topic_score_codex":0.00053766626,"about_ca_topic_score_gemma":0.0015335046,"teacher_disagreement_score":0.0021146666,"about_ca_system_score_codex":0.00033363386,"about_ca_system_score_gemma":0.00040588377,"threshold_uncertainty_score":0.007074237},"labels":[],"label_agreement":null},{"id":"W2172037660","doi":"10.1016/j.bmcl.2014.08.011","title":"ASK1 pharmacophore model derived from diverse classes of inhibitors","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Tobacco Research Unit","funders":"National Academy of Sciences of Ukraine","keywords":"Pharmacophore; Chemistry; ASK1; Virtual screening; Computational biology; Kinase; Combinatorial chemistry; Stereochemistry; Biochemistry; Protein kinase A; Biology; Mitogen-activated protein kinase kinase","score_opus":0.01723774134064304,"score_gpt":0.2618642959517762,"score_spread":0.24462655461113314,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172037660","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6923577,0.0030390075,0.21231258,0.0018994894,0.00012635534,0.0003066338,0.011137333,0.001884073,0.076936826],"genre_scores_gemma":[0.9778,0.00090695167,0.013785908,0.00017330683,0.000012450099,0.00013561922,0.0035190843,0.00008627967,0.0035803306],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9999542,0.000011202644,0.0000022042404,0.000008296533,0.000013630645,0.000010497178],"domain_scores_gemma":[0.9999447,0.000026991254,0.0000058663263,0.0000045199968,0.000012512932,0.0000054961133],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011337386,0.0004083704,0.0005546105,0.00033887927,0.0002269038,0.00038696706,0.0005104277,0.00061723625,0.0043412335],"category_scores_gemma":[0.00032933665,0.00014974213,0.00047871075,0.00046661383,0.000178195,0.00037799557,0.00018180166,0.00044875132,0.00057357154],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006623877,0.00013191612,0.0007427791,0.00038905686,0.00007095178,0.00037131784,0.000030737407,0.9387447,0.020515665,0.016298054,0.0040476527,0.017994758],"study_design_scores_gemma":[0.000095533025,0.00007694522,0.00032113385,0.000011647252,0.00004711302,0.00006769371,0.000016267872,0.9879304,0.0048586237,0.0049220105,0.0016415097,0.000011152385],"about_ca_topic_score_codex":0.0035075378,"about_ca_topic_score_gemma":0.003833995,"teacher_disagreement_score":0.0043412335,"about_ca_system_score_codex":0.00037098382,"about_ca_system_score_gemma":0.00078718277,"threshold_uncertainty_score":0.01452291},"labels":[],"label_agreement":null},{"id":"W2172317070","doi":"10.1016/j.bmcl.2004.01.075","title":"Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Stereochemistry; Yield (engineering); Selectivity; Alkyl; Cyclooxygenase; Chemical synthesis; Enzyme; In vitro; Organic chemistry; Biochemistry; Catalysis","score_opus":0.011127895678430895,"score_gpt":0.2222192187021264,"score_spread":0.21109132302369552,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172317070","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9154306,0.015609777,0.049339347,0.0009161663,0.00032801164,0.00055958447,0.0014792789,0.00066746405,0.015669685],"genre_scores_gemma":[0.9615098,0.009632236,0.018644685,0.0003717599,0.000067708614,0.00021272458,0.0012791087,0.000047162594,0.008234768],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992204,0.000009651926,0.000006984358,0.000016000899,0.000013474083,0.000031749023],"domain_scores_gemma":[0.99995315,0.0000038924504,0.000011854734,0.00000424011,0.0000075171047,0.000019447447],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022704684,0.00045808055,0.00034050678,0.00031220986,0.000181845,0.00035518053,0.0005224187,0.00026160578,0.0022206255],"category_scores_gemma":[0.00011623757,0.00016584544,0.00024072481,0.00023851192,0.00016036407,0.00030878844,0.00029325986,0.000446356,0.00046984793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016123013,0.0004298548,0.00054113445,0.00035079592,0.000055600107,0.0006695862,0.00010532959,0.0041172267,0.9196471,0.0059876363,0.0017095067,0.06477393],"study_design_scores_gemma":[0.000788103,0.005551545,0.0014818661,0.00006210484,0.00021288899,0.0011841748,0.00007047139,0.0054687974,0.91270375,0.0012213027,0.07118787,0.00006714551],"about_ca_topic_score_codex":0.00035127666,"about_ca_topic_score_gemma":0.0012581564,"teacher_disagreement_score":0.0022206255,"about_ca_system_score_codex":0.00033313295,"about_ca_system_score_gemma":0.00035630306,"threshold_uncertainty_score":0.0074287653},"labels":[],"label_agreement":null},{"id":"W2172450144","doi":"10.1016/s0960-894x(03)00640-1","title":"Synthesis and evaluation of 4-Anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Aniline; Kinase; MAPK/ERK pathway; Phosphorylation; Mitogen-activated protein kinase; Structure–activity relationship; Stereochemistry; Biochemistry; In vitro; Organic chemistry","score_opus":0.013331390779175218,"score_gpt":0.2330483175607817,"score_spread":0.21971692678160648,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172450144","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9658689,0.009928187,0.01157899,0.0003046956,0.00013453554,0.0006450175,0.0007350426,0.00023743548,0.010567206],"genre_scores_gemma":[0.9850134,0.004860349,0.0047517903,0.000110945264,0.00003476582,0.00015125307,0.0006582125,0.000026813086,0.004392428],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998497,0.000040811323,0.000012047754,0.000020985563,0.000029287536,0.00004709767],"domain_scores_gemma":[0.99987686,0.000023124387,0.000028917479,0.000012964557,0.000027797338,0.00003035142],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005196267,0.00042046857,0.00039667916,0.00036311694,0.00021814367,0.00025860412,0.00065094803,0.00045127448,0.0017701758],"category_scores_gemma":[0.00026627217,0.000192926,0.0003020102,0.00015600823,0.00020698477,0.00025460872,0.00020478554,0.00039708114,0.0005281337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00094525027,0.00039101613,0.00024081099,0.00031943372,0.0000412227,0.00056922034,0.0001306818,0.0026327383,0.9759635,0.0011959171,0.00043034466,0.0171399],"study_design_scores_gemma":[0.00061146216,0.0049418863,0.0021505824,0.000029818864,0.00008345825,0.0006809878,0.000043835364,0.0022383279,0.97722536,0.0001673993,0.011786372,0.000040500974],"about_ca_topic_score_codex":0.00064076413,"about_ca_topic_score_gemma":0.0010439871,"teacher_disagreement_score":0.0017701758,"about_ca_system_score_codex":0.0002693294,"about_ca_system_score_gemma":0.0002725085,"threshold_uncertainty_score":0.005921781},"labels":[],"label_agreement":null},{"id":"W2172486499","doi":"10.1016/j.bmcl.2004.06.031","title":"Benzodiazepine inhibitors of the MMPs and TACE. Part 2","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Benzodiazepine; Matrix metalloproteinase; Pharmacology; In vitro; Enzyme inhibitor; Chemical synthesis; Inhibitory postsynaptic potential; Structure–activity relationship; Enzyme; Stereochemistry; Biochemistry; Receptor; Internal medicine","score_opus":0.004316665112411269,"score_gpt":0.18376384017917613,"score_spread":0.17944717506676486,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172486499","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.20620653,0.71406394,0.008497281,0.003856772,0.0016433558,0.00045097867,0.0013898475,0.00040157646,0.06348975],"genre_scores_gemma":[0.5033276,0.39783752,0.0036267154,0.0023359607,0.0019876952,0.00045351262,0.0022222078,0.00004744685,0.08816135],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999205,0.000015010673,0.000006122929,0.000006117548,0.0000199242,0.00003239351],"domain_scores_gemma":[0.99996006,0.000010051357,0.000010779028,0.0000035736005,0.000005702663,0.000009803117],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015671854,0.0005499898,0.00029884407,0.0005173913,0.00012824031,0.00030974584,0.00039358874,0.00032365366,0.0049130186],"category_scores_gemma":[0.0001397068,0.00017352444,0.00030969622,0.0002084913,0.00022712888,0.00032535644,0.0001651503,0.0004998315,0.001497508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.005449939,0.0012750373,0.00052286993,0.0027675969,0.00020161748,0.0014576965,0.00013972876,0.0021104873,0.48457867,0.008351929,0.038083047,0.4550614],"study_design_scores_gemma":[0.0027680155,0.009489974,0.022675678,0.00031724104,0.00030206752,0.010432284,0.00008411062,0.0017644617,0.36570343,0.0037476062,0.5826274,0.00008760087],"about_ca_topic_score_codex":0.00064122234,"about_ca_topic_score_gemma":0.0012167402,"teacher_disagreement_score":0.0049130186,"about_ca_system_score_codex":0.00042460542,"about_ca_system_score_gemma":0.00030931205,"threshold_uncertainty_score":0.016435742},"labels":[],"label_agreement":null},{"id":"W2172566340","doi":"10.1016/j.bmcl.2004.06.079","title":"Pyridoxine as a template for the design of antiplatelet agents","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"CanAm Bioresearch (Canada)","funders":"","keywords":"Pyridoxine; Chemistry; Pharmacology; Combinatorial chemistry; Biochemistry; Medicine","score_opus":0.024722341153428876,"score_gpt":0.2664363320021246,"score_spread":0.24171399084869571,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172566340","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90114844,0.013342587,0.056929912,0.0009512011,0.0004088206,0.00049366563,0.0006076976,0.0005376901,0.025579855],"genre_scores_gemma":[0.96827835,0.0050172303,0.020475365,0.00019454981,0.000030487174,0.0001178032,0.00035554258,0.00003774751,0.0054929513],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999889,0.000021700675,0.000010740605,0.000025106952,0.000028105693,0.000025283824],"domain_scores_gemma":[0.9999479,0.000010816679,0.000010784038,0.000009476415,0.000007265722,0.0000138283585],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025851096,0.00029523933,0.00027344155,0.00012845217,0.00021346094,0.00044997703,0.00043254838,0.0004311771,0.0008855142],"category_scores_gemma":[0.00020816653,0.00025392266,0.00018925362,0.00014693369,0.00017314976,0.00034632196,0.00026833543,0.0006179617,0.0005339424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047225476,0.00019372483,0.00035089758,0.0004474469,0.000040955827,0.0008794885,0.0001762304,0.006673326,0.94986725,0.007845995,0.0007927374,0.032259725],"study_design_scores_gemma":[0.00018784375,0.0012358207,0.00038869897,0.00003118279,0.000040436476,0.00055572565,0.00004122513,0.004624467,0.9656596,0.0011826673,0.026022362,0.000029951154],"about_ca_topic_score_codex":0.00034114928,"about_ca_topic_score_gemma":0.00063741324,"teacher_disagreement_score":0.0008855142,"about_ca_system_score_codex":0.0003148075,"about_ca_system_score_gemma":0.00031603893,"threshold_uncertainty_score":0.0029623508},"labels":[],"label_agreement":null},{"id":"W2172793471","doi":"10.1016/j.bmcl.2006.05.026","title":"Design and synthesis of butynyloxyphenyl β-sulfone piperidine hydroxamates as TACE inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Piperidine; Sulfone; Chemical synthesis; Enzyme inhibitor; Stereochemistry; Pharmacology; Combinatorial chemistry; In vitro; Biochemistry; Organic chemistry","score_opus":0.008673794685695919,"score_gpt":0.23225251387414625,"score_spread":0.22357871918845032,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172793471","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9409381,0.008243403,0.03900857,0.00044779407,0.00021647754,0.0005011437,0.0006245497,0.00033074204,0.009689247],"genre_scores_gemma":[0.97590375,0.004026367,0.014866213,0.00014187334,0.000034367877,0.00016249454,0.00043471533,0.000024582234,0.0044057216],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999081,0.000016431894,0.0000125590395,0.00001379684,0.000019275007,0.000029892515],"domain_scores_gemma":[0.9999372,0.00000776799,0.000020854344,0.000006653242,0.000011954395,0.000015604575],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002668707,0.0003469381,0.00030229278,0.00018129603,0.00014267993,0.00024068373,0.00034097634,0.0002601299,0.0011147201],"category_scores_gemma":[0.0001684371,0.00020640616,0.00014822352,0.00013854099,0.00014105998,0.00025908859,0.00016430997,0.0004022238,0.00034726932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028681487,0.000089271365,0.00011190359,0.00015928052,0.000011112177,0.00030428384,0.00005942049,0.0009076024,0.97867936,0.0012337448,0.0003043146,0.017852971],"study_design_scores_gemma":[0.0001557627,0.0013438953,0.00053473545,0.000013925436,0.000031733023,0.00034952682,0.000018333136,0.0017694274,0.98388714,0.0001275675,0.011755938,0.0000120158265],"about_ca_topic_score_codex":0.00024427474,"about_ca_topic_score_gemma":0.00061277795,"teacher_disagreement_score":0.0011147201,"about_ca_system_score_codex":0.0002223004,"about_ca_system_score_gemma":0.00019983065,"threshold_uncertainty_score":0.003729105},"labels":[],"label_agreement":null},{"id":"W2172823456","doi":"10.1016/j.bmcl.2005.09.021","title":"Pulvinones as bacterial cell wall biosynthesis inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Enterococcus faecalis; Streptococcus pneumoniae; Bacteria; Chemistry; Enzyme; Microbiology; Biosynthesis; Bacterial cell structure; Penicillin; Antibacterial agent; Antibiotics; Enterococcus; Streptococcaceae; Biochemistry; Biology; Escherichia coli; Gene","score_opus":0.006718256731812102,"score_gpt":0.20679302271369776,"score_spread":0.20007476598188567,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172823456","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85177237,0.07881752,0.016756412,0.001383876,0.0013438349,0.0002695648,0.001394045,0.0009671603,0.047295224],"genre_scores_gemma":[0.9599438,0.021134395,0.0029799342,0.0003547775,0.00007044791,0.000065972876,0.00064314913,0.00005568442,0.014751879],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991405,0.000019174631,0.0000063975594,0.000010858057,0.00001630637,0.00003313847],"domain_scores_gemma":[0.9999392,0.00001608744,0.000009540824,0.000009484324,0.0000069191487,0.0000188002],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002107532,0.00048519118,0.0002650925,0.00031780254,0.00020226825,0.0005455233,0.0003950529,0.00035743258,0.0028756368],"category_scores_gemma":[0.0001800675,0.00020318039,0.00019916793,0.0001755436,0.0002101929,0.00048706675,0.00041872103,0.00072026876,0.0007136515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015557605,0.00019736483,0.0004005022,0.00042548796,0.000044144846,0.0008747452,0.0001436532,0.0028178892,0.91242963,0.0061351485,0.0022488378,0.07272681],"study_design_scores_gemma":[0.00022619676,0.0012072063,0.000921089,0.00004595146,0.00004400785,0.00037968354,0.000032247837,0.0014658766,0.9542328,0.0004948046,0.040928088,0.000022185885],"about_ca_topic_score_codex":0.00058517617,"about_ca_topic_score_gemma":0.0010912025,"teacher_disagreement_score":0.0028756368,"about_ca_system_score_codex":0.0004002532,"about_ca_system_score_gemma":0.00019393225,"threshold_uncertainty_score":0.009619951},"labels":[],"label_agreement":null},{"id":"W2172890621","doi":"10.1016/s0960-894x(03)00480-3","title":"High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Canada Research Chairs","keywords":"Dihydrofolate reductase; Escherichia coli; Enzyme; Chemistry; Small molecule; Biochemistry; Enzyme inhibitor; High-throughput screening; Gene","score_opus":0.012601848751342072,"score_gpt":0.22840302467089313,"score_spread":0.21580117591955106,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172890621","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9741745,0.006781326,0.011010712,0.0005739131,0.00009603634,0.00025734404,0.001701983,0.00071380916,0.004690398],"genre_scores_gemma":[0.9762171,0.004219389,0.007866354,0.00030614046,0.000042070733,0.00012849641,0.004017616,0.000053011547,0.007149789],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99972075,0.00003545252,0.00001523519,0.000043388685,0.00011841931,0.00006666781],"domain_scores_gemma":[0.99985707,0.00005349756,0.000025936379,0.000012828081,0.000025366966,0.000025203284],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033533448,0.0009198223,0.00093441975,0.00052373897,0.00034202743,0.000774224,0.0006526476,0.0006662282,0.0018753409],"category_scores_gemma":[0.0002977012,0.00040502072,0.00039265314,0.00041534254,0.0002152702,0.00024232526,0.0002600565,0.0006946325,0.0008773257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006417373,0.00060652726,0.0009215913,0.00010867245,0.00006876618,0.00019629212,0.00001629573,0.000888836,0.98095506,0.00015796571,0.0007646193,0.014673594],"study_design_scores_gemma":[0.00026318134,0.002121185,0.0030156372,0.000009179083,0.0001786687,0.0010312224,0.000023617793,0.0050399983,0.982553,0.00006755338,0.0056729647,0.000023809525],"about_ca_topic_score_codex":0.0013334348,"about_ca_topic_score_gemma":0.0047536204,"teacher_disagreement_score":0.0018753409,"about_ca_system_score_codex":0.0007826496,"about_ca_system_score_gemma":0.00045813102,"threshold_uncertainty_score":0.0062736273},"labels":[],"label_agreement":null},{"id":"W2172933245","doi":"10.1016/j.bmcl.2004.10.065","title":"(S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Acrylamide; Moiety; Potency; Stereochemistry; Potassium channel opener; Chemical synthesis; Potassium channel; Potassium; Organic chemistry; In vitro; Biochemistry","score_opus":0.011715169095327268,"score_gpt":0.21426906153290914,"score_spread":0.20255389243758187,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2172933245","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95734626,0.0056338813,0.017506478,0.000340605,0.00017415549,0.00018876673,0.00052981346,0.00049362343,0.01778641],"genre_scores_gemma":[0.985698,0.0021200746,0.006261973,0.0001166571,0.000050230567,0.00011304347,0.00026735768,0.000050300845,0.0053224354],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997868,0.00004032082,0.000019193942,0.000049110582,0.000031038653,0.00007363252],"domain_scores_gemma":[0.9998677,0.00002466307,0.00003779826,0.000015842877,0.000016637876,0.000037332044],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036927688,0.00040887503,0.00030236368,0.00027539697,0.00028060048,0.00021462646,0.0004310955,0.0003575016,0.0023043116],"category_scores_gemma":[0.00028545698,0.00018652058,0.00021345585,0.00017507088,0.00024285723,0.00039288733,0.00026756647,0.0003462429,0.00077868125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00069767743,0.00011427541,0.00012399346,0.00013381112,0.000012166069,0.00031033726,0.000061876024,0.0005636789,0.9861113,0.0010111162,0.00044727366,0.0104125785],"study_design_scores_gemma":[0.00014894856,0.0012169076,0.0010864317,0.000008791398,0.000019303365,0.00045034412,0.0000202636,0.0005501346,0.99088484,0.000100325065,0.0054941345,0.00001968302],"about_ca_topic_score_codex":0.0009000898,"about_ca_topic_score_gemma":0.001416276,"teacher_disagreement_score":0.0023043116,"about_ca_system_score_codex":0.00039010207,"about_ca_system_score_gemma":0.00030403823,"threshold_uncertainty_score":0.0077087283},"labels":[],"label_agreement":null},{"id":"W2173405796","doi":"10.1016/s0960-894x(03)00391-3","title":"6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Alkoxy group; Stereochemistry; Pyran; Alkyl; Ring (chemistry); Lactone; Cyclooxygenase; Enzyme; Organic chemistry","score_opus":0.013621314555418066,"score_gpt":0.24155963978539177,"score_spread":0.2279383252299737,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173405796","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.955158,0.01736326,0.009489597,0.0004519447,0.00023713223,0.000110712994,0.00087917474,0.0004676492,0.01584255],"genre_scores_gemma":[0.97274417,0.008872084,0.0058308174,0.00023275218,0.00010286273,0.00013821815,0.0006705452,0.000025585348,0.011382984],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995553,0.0000065296686,0.000002964912,0.00000667594,0.000009712601,0.000018675006],"domain_scores_gemma":[0.99997187,0.000004285579,0.0000086709315,0.0000029088721,0.0000028995962,0.000009424637],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010177589,0.00031938622,0.0002517824,0.00014789148,0.00011962459,0.00015045704,0.00041779142,0.00017490586,0.0025063346],"category_scores_gemma":[0.0000688925,0.00013259765,0.000115311006,0.00011891423,0.00011177559,0.00022377686,0.0001442149,0.0003653874,0.00068729644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011738728,0.00017807794,0.00031530394,0.00034279888,0.000018262956,0.00049030065,0.00009481038,0.0006930409,0.947025,0.001733942,0.0014678268,0.046466738],"study_design_scores_gemma":[0.00057738007,0.003706585,0.0041249427,0.000031941487,0.00007050343,0.0017010481,0.000056799592,0.0028436384,0.9497957,0.00033532333,0.036721136,0.00003497697],"about_ca_topic_score_codex":0.00020046021,"about_ca_topic_score_gemma":0.00092018256,"teacher_disagreement_score":0.0025063346,"about_ca_system_score_codex":0.00018840183,"about_ca_system_score_gemma":0.00018458787,"threshold_uncertainty_score":0.008384585},"labels":[],"label_agreement":null},{"id":"W2173519474","doi":"10.1016/s0960-894x(02)00615-7","title":"Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacokinetics; Phosphodiesterase; In vivo; Enzyme inhibitor; Pharmacology; Chemical synthesis; Enzyme; Stereochemistry; In vitro; Biochemistry; Medicine","score_opus":0.01585131260705913,"score_gpt":0.23381015343166098,"score_spread":0.21795884082460185,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173519474","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9801789,0.009394325,0.0049887076,0.00018397886,0.000100098005,0.00008696018,0.00022463019,0.000079221645,0.0047630984],"genre_scores_gemma":[0.9883322,0.005509307,0.0033268065,0.000075169264,0.00002475049,0.0000495852,0.0002623177,0.000015536067,0.0024043708],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999349,0.00002181557,0.0000042400893,0.000008084318,0.000014112822,0.000016825947],"domain_scores_gemma":[0.99995995,0.0000119483875,0.000010271226,0.0000045082784,0.00000431406,0.0000090902695],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272522,0.00031334895,0.0003200916,0.00012389047,0.0001086458,0.00016782724,0.00037078687,0.00025603254,0.00088748947],"category_scores_gemma":[0.00020198611,0.00017554108,0.00015769919,0.00013477939,0.00014237576,0.0002627987,0.00014935726,0.0005476815,0.00024597827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013893781,0.00019834582,0.00021459247,0.00020152023,0.000025624113,0.00031005015,0.00007058909,0.0021554716,0.97546375,0.00085165055,0.0003517484,0.018767389],"study_design_scores_gemma":[0.0005466064,0.005404165,0.0019548952,0.000025111873,0.00007068098,0.0007457513,0.000040683582,0.0058804657,0.97791356,0.00024082341,0.007150802,0.000026505926],"about_ca_topic_score_codex":0.00052059017,"about_ca_topic_score_gemma":0.0013329199,"teacher_disagreement_score":0.00088748947,"about_ca_system_score_codex":0.00022678007,"about_ca_system_score_gemma":0.00018405831,"threshold_uncertainty_score":0.0029689074},"labels":[],"label_agreement":null},{"id":"W2173607797","doi":"10.1016/j.bmcl.2005.08.003","title":"Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Aspartic acid; Glutamate receptor; Amino acid; Excitatory amino-acid transporter; Biochemistry; Forebrain; Glutamic acid; Excitatory Amino Acid Antagonists; Stereochemistry; Pharmacology; Central nervous system; Biology; Neuroscience; Receptor","score_opus":0.022522989411256987,"score_gpt":0.24878376983831962,"score_spread":0.22626078042706263,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173607797","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9786556,0.010162576,0.003164984,0.00014678696,0.00010682472,0.00013013624,0.0008029747,0.00010182599,0.006728202],"genre_scores_gemma":[0.98869485,0.0048727184,0.0023128146,0.00007038569,0.000026477732,0.000050249982,0.0008586509,0.000013919651,0.003100035],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992025,0.000012361166,0.000009493583,0.0000123323425,0.000019657658,0.000025902074],"domain_scores_gemma":[0.9999509,0.000007818218,0.000011777506,0.000005022238,0.000007746487,0.000016744385],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017085129,0.0004060928,0.0003085342,0.00020852967,0.00015976638,0.00024339384,0.00038554924,0.00025615635,0.0012675559],"category_scores_gemma":[0.00014539558,0.00018264208,0.0002185017,0.00020763627,0.00012263915,0.00022704704,0.00014659153,0.0003591683,0.00035278872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00073095126,0.000116299976,0.00009540363,0.00008870041,0.000018944087,0.00019399206,0.00002307643,0.00056083646,0.99109066,0.00027175504,0.00017158756,0.0066378447],"study_design_scores_gemma":[0.0002706191,0.0018972686,0.0011818076,0.000007514717,0.000053656186,0.0003205255,0.0000142240115,0.0008415505,0.989449,0.00006949622,0.0058779265,0.000016539103],"about_ca_topic_score_codex":0.00070694607,"about_ca_topic_score_gemma":0.0011648368,"teacher_disagreement_score":0.0012675559,"about_ca_system_score_codex":0.00022972518,"about_ca_system_score_gemma":0.00022456922,"threshold_uncertainty_score":0.0042403936},"labels":[],"label_agreement":null},{"id":"W2173616003","doi":"10.1016/j.bmcl.2007.06.012","title":"Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Mutant; Bioavailability; Nucleoside; Enzyme; Enzyme inhibitor; Nucleotidyltransferase; Stereochemistry; Biochemistry; Pharmacology; RNA; Biology; Gene","score_opus":0.007492722331657846,"score_gpt":0.21867622616240145,"score_spread":0.2111835038307436,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173616003","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99125755,0.0038850734,0.000766163,0.00011752582,0.000055987508,0.00003733444,0.00014308805,0.00010708566,0.0036301226],"genre_scores_gemma":[0.99403524,0.0025411926,0.0006775495,0.000043678083,0.00002004364,0.00002083102,0.00024295598,0.000014779353,0.0024037464],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998883,0.000028632989,0.000008551758,0.000010388067,0.000033086144,0.000030905598],"domain_scores_gemma":[0.9999243,0.000017826005,0.000018679002,0.000007570434,0.000008928705,0.000022674607],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015208378,0.0003183869,0.00031366013,0.00020980586,0.00019024854,0.00025812673,0.0003601637,0.00023521208,0.001346118],"category_scores_gemma":[0.0002089833,0.00016408716,0.00012882629,0.00023131935,0.00019017544,0.00013188759,0.00012315103,0.00043536324,0.00028057105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013766641,0.00014593922,0.0002703973,0.00009202375,0.000021886739,0.0003603805,0.00006315267,0.00087133364,0.98302907,0.00057885976,0.0003883269,0.012801859],"study_design_scores_gemma":[0.00061737606,0.004994879,0.0032860595,0.000015570882,0.00008622944,0.0014898763,0.000044753593,0.0028272101,0.97947,0.00011454931,0.007027276,0.000026241645],"about_ca_topic_score_codex":0.0014285708,"about_ca_topic_score_gemma":0.004767879,"teacher_disagreement_score":0.0014285708,"about_ca_system_score_codex":0.00027851725,"about_ca_system_score_gemma":0.0002873687,"threshold_uncertainty_score":0.0045031905},"labels":[],"label_agreement":null},{"id":"W2173814407","doi":"10.1016/j.bmcl.2004.02.100","title":"Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Muscarinic acetylcholine receptor; Receptor; 5-HT2C receptor; Serotonin; Pharmacology; In vivo; Histamine; 5-HT receptor; Stereochemistry; Chemical synthesis; In vitro; Biochemistry; Biology","score_opus":0.026108946550063628,"score_gpt":0.26414899252675433,"score_spread":0.2380400459766907,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173814407","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9787325,0.0108481,0.001406121,0.00044910106,0.000047292848,0.000026561895,0.0003024499,0.00006522375,0.008122636],"genre_scores_gemma":[0.99442804,0.0031045333,0.0003712158,0.00014730592,0.000028533199,0.000013224448,0.00013811437,0.0000043449445,0.0017646654],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999336,0.000022084381,0.0000028302534,0.000007448544,0.000011907042,0.000022130616],"domain_scores_gemma":[0.99991167,0.00003157284,0.000029387813,0.0000045963957,0.000010823118,0.00001186681],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006911465,0.00012851392,0.00010045101,0.00012169996,0.00016839839,0.00015836568,0.00014372796,0.0002949287,0.0039909096],"category_scores_gemma":[0.00020511444,0.00008766001,0.00008145234,0.00011056552,0.000115697156,0.00009713975,0.00009752392,0.00026524573,0.0004503338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019408984,0.00007560461,0.0035773474,0.0002358325,0.000032399817,0.00083369587,0.000104244835,0.00020652253,0.96639854,0.0010633231,0.001017195,0.024514286],"study_design_scores_gemma":[0.00041215276,0.004840351,0.13467866,0.00009301449,0.0001767694,0.006166109,0.00039370882,0.002012372,0.8205136,0.0007672715,0.029899143,0.000046828776],"about_ca_topic_score_codex":0.0024058188,"about_ca_topic_score_gemma":0.0074055265,"teacher_disagreement_score":0.0039909096,"about_ca_system_score_codex":0.00026048726,"about_ca_system_score_gemma":0.00013809111,"threshold_uncertainty_score":0.013350964},"labels":[],"label_agreement":null},{"id":"W2173957951","doi":"10.1016/s0960-894x(02)00634-0","title":"Synthesis of nitrile derivatives of estrogens","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"GaN-based semiconductor devices and materials","field":"Physics and Astronomy","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Nitrile; Aromatization; Acetonitrile; Ring (chemistry); Bromide; Halogenation; Medicinal chemistry; Organic chemistry; Stereochemistry","score_opus":0.014322945648205142,"score_gpt":0.2137654917728778,"score_spread":0.19944254612467266,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173957951","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9211517,0.009558295,0.017166305,0.00059747713,0.00035053946,0.00022437125,0.0013714577,0.00020113046,0.049378723],"genre_scores_gemma":[0.9673931,0.0056228633,0.00671344,0.0001807333,0.000038180086,0.00008003435,0.00070732756,0.00003451412,0.019229826],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999212,0.000014357129,0.0000055202263,0.000010826865,0.000016007221,0.000032105785],"domain_scores_gemma":[0.99995255,0.000007267717,0.000009605957,0.0000075119974,0.000008080576,0.000014941585],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016548354,0.00027419237,0.00019796172,0.00013185362,0.00015841809,0.00012035376,0.00031386683,0.00018860996,0.0027168195],"category_scores_gemma":[0.000119916614,0.00010832273,0.00018405358,0.000113842834,0.00012433024,0.00018115122,0.0002483508,0.00036041855,0.00063537166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00049691915,0.0001526079,0.00032048434,0.00036465644,0.000032632182,0.0007596466,0.00012594913,0.0017294299,0.9680038,0.0046311575,0.00088808464,0.022494517],"study_design_scores_gemma":[0.00005323008,0.0008296987,0.0008715894,0.000020020381,0.0000174034,0.0004115395,0.0000331074,0.00067691726,0.9672482,0.00042229166,0.029400468,0.000015529562],"about_ca_topic_score_codex":0.00036116558,"about_ca_topic_score_gemma":0.0010811167,"teacher_disagreement_score":0.0027168195,"about_ca_system_score_codex":0.00023284684,"about_ca_system_score_gemma":0.00025258763,"threshold_uncertainty_score":0.009088635},"labels":[],"label_agreement":null},{"id":"W2173997812","doi":"10.1016/s0960-894x(02)01030-2","title":"Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Bronchoconstriction; Aminopyridines; Ovalbumin; Phosphodiesterase; Pharmacology; Guinea pig; Chemical synthesis; Stereochemistry; Biological activity; Structure–activity relationship; Biochemistry; In vitro; Enzyme; Internal medicine; Medicinal chemistry; Antigen; Immunology","score_opus":0.004705899955193626,"score_gpt":0.20237309872269546,"score_spread":0.19766719876750183,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173997812","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9139843,0.04957454,0.011447308,0.00066757353,0.00083602336,0.00024934078,0.0009472699,0.0007065299,0.021587221],"genre_scores_gemma":[0.96711737,0.019946856,0.004500568,0.00025939365,0.0001235362,0.000091016154,0.00066208147,0.00004368644,0.0072553717],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998567,0.000030950072,0.000010884201,0.000018305424,0.000034107346,0.000049025763],"domain_scores_gemma":[0.99994755,0.000011097278,0.000012060143,0.00000572904,0.000007085338,0.000016591603],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026567598,0.0005926608,0.0005546488,0.00030720312,0.00017716967,0.0002840423,0.0006389895,0.00040140754,0.0019636613],"category_scores_gemma":[0.0001745703,0.00030405098,0.00019440435,0.00024566957,0.0001998739,0.0003042969,0.0003235759,0.0007859385,0.0005798145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0020058374,0.0002461023,0.00017175941,0.00041682267,0.000048069032,0.00062558026,0.00007022187,0.0021713555,0.9494771,0.002177558,0.0016976427,0.040891875],"study_design_scores_gemma":[0.001126252,0.0062434603,0.0018732471,0.00004475625,0.00014174785,0.0014781243,0.000033096625,0.0035687743,0.95185167,0.00045087747,0.03313349,0.000054446926],"about_ca_topic_score_codex":0.00049582747,"about_ca_topic_score_gemma":0.0014145573,"teacher_disagreement_score":0.0019636613,"about_ca_system_score_codex":0.00032757493,"about_ca_system_score_gemma":0.00018875067,"threshold_uncertainty_score":0.006569147},"labels":[],"label_agreement":null},{"id":"W2174122554","doi":"10.1016/j.bmcl.2003.11.049","title":"Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Nevirapine; Chemistry; Pharmacokinetics; Microsome; Mutant; Pharmacology; Virology; Virus; Human immunodeficiency virus (HIV); Structure–activity relationship; In vitro; Biochemistry; Viral load; Antiretroviral therapy","score_opus":0.01144913933502341,"score_gpt":0.22079358025555568,"score_spread":0.20934444092053225,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2174122554","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96883214,0.010511007,0.007145743,0.0004083734,0.00018135844,0.00023090157,0.0007314009,0.00044161335,0.011517466],"genre_scores_gemma":[0.98168737,0.0058699776,0.0066143954,0.00023792076,0.0000577092,0.000088527406,0.0008188458,0.000025267269,0.004599939],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999553,0.000007206154,0.0000034838874,0.000006904317,0.000012350146,0.000014685559],"domain_scores_gemma":[0.99997246,0.0000033224883,0.0000063387306,0.0000028750724,0.000003633718,0.000011450047],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012380743,0.0003070857,0.00032560903,0.00016404415,0.00012401634,0.00018763132,0.00041056648,0.00020327844,0.0010120865],"category_scores_gemma":[0.00009569565,0.00013179619,0.00014651103,0.00010385441,0.00009336576,0.00012194065,0.00013615924,0.00040848582,0.00028240404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008532641,0.00020072101,0.00034799997,0.00017235398,0.000039378596,0.00072781806,0.00007045984,0.00074830034,0.9370564,0.0009048004,0.001131608,0.0577469],"study_design_scores_gemma":[0.0018303022,0.005530904,0.012078572,0.000036679845,0.0002159706,0.0055270763,0.000042666717,0.004775262,0.916578,0.0003082489,0.053017125,0.000059182432],"about_ca_topic_score_codex":0.0006650691,"about_ca_topic_score_gemma":0.0031905486,"teacher_disagreement_score":0.0010120865,"about_ca_system_score_codex":0.00024703777,"about_ca_system_score_gemma":0.00015785987,"threshold_uncertainty_score":0.0033857822},"labels":[],"label_agreement":null},{"id":"W2174408153","doi":"10.1016/s0960-894x(02)00942-3","title":"Thiophene-based vitronectin receptor antagonists","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Chemistry; Thiophene; Vitronectin; In vitro; Chorioallantoic membrane; Receptor; Chemical synthesis; Biological activity; Antagonist; Stereochemistry; Pharmacology; Biochemistry; Integrin","score_opus":0.013758427053822112,"score_gpt":0.25992954021012393,"score_spread":0.24617111315630183,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2174408153","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93533844,0.023464223,0.015769828,0.0013371379,0.0006086969,0.0003787992,0.00066506374,0.0005319145,0.021905916],"genre_scores_gemma":[0.9558015,0.018422192,0.006162757,0.0007070617,0.00010919394,0.00018186263,0.0011330982,0.000060884526,0.017421508],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986804,0.000033573047,0.000006041383,0.000015851558,0.000033653832,0.000042854143],"domain_scores_gemma":[0.9999409,0.000014011267,0.000010204901,0.000008917993,0.0000094354355,0.000016549457],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101943,0.0005458934,0.00038625815,0.000283318,0.00023339207,0.0003062279,0.0006863726,0.00037445794,0.0021246255],"category_scores_gemma":[0.00022123744,0.00025245931,0.000270114,0.00017096047,0.00024240611,0.00029664807,0.00028657063,0.00093936647,0.00073933124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00080300024,0.00016521315,0.0001121418,0.00019678798,0.000058881375,0.00035244023,0.00006607841,0.0012654128,0.9670679,0.0016175186,0.0014223022,0.026872365],"study_design_scores_gemma":[0.0004458626,0.0026481824,0.001095976,0.000031866366,0.00008690268,0.0010011594,0.000038303406,0.002926944,0.9651809,0.00040948828,0.026103834,0.00003062934],"about_ca_topic_score_codex":0.0005879505,"about_ca_topic_score_gemma":0.0018397578,"teacher_disagreement_score":0.0021246255,"about_ca_system_score_codex":0.00037031897,"about_ca_system_score_gemma":0.00024501834,"threshold_uncertainty_score":0.0071076155},"labels":[],"label_agreement":null},{"id":"W2174493882","doi":"10.1016/j.bmcl.2004.11.051","title":"Structure–activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Agonist; Prostaglandin E2 receptor; Stereochemistry; Chemical synthesis; In vivo; Biological activity; Selectivity; Receptor; Structure–activity relationship; In vitro; Pharmacology; Biochemistry","score_opus":0.019800307573990122,"score_gpt":0.2775610790037536,"score_spread":0.2577607714297635,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2174493882","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98488635,0.010522528,0.0008051737,0.00013175362,0.000053596785,0.00008959848,0.0006122778,0.00003254308,0.0028661261],"genre_scores_gemma":[0.9864915,0.00832522,0.00093679945,0.00011056737,0.000056364086,0.00004518718,0.0010004665,0.000009996072,0.003023906],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986625,0.000028717432,0.000009153573,0.000014161519,0.000027156362,0.000054453925],"domain_scores_gemma":[0.9998635,0.000036012694,0.000029809282,0.000014580002,0.000020711279,0.0000353835],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029794028,0.00046659517,0.000477888,0.00030710295,0.00016860082,0.0002454399,0.0003571868,0.00022545762,0.003184967],"category_scores_gemma":[0.00026805236,0.0001650626,0.00040285353,0.00031175953,0.00025902386,0.00024346067,0.00012365218,0.00068706693,0.0003397572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.007203215,0.0007848136,0.00054581225,0.00029568234,0.00011746781,0.00028045228,0.00006489793,0.0007942575,0.9721815,0.00033840715,0.00042602344,0.016967341],"study_design_scores_gemma":[0.0019121572,0.0445248,0.01843736,0.000036192447,0.0008709837,0.0016161447,0.00009043415,0.0024061615,0.9137775,0.00023888862,0.016014762,0.00007454278],"about_ca_topic_score_codex":0.001783482,"about_ca_topic_score_gemma":0.0045701815,"teacher_disagreement_score":0.003184967,"about_ca_system_score_codex":0.0002895744,"about_ca_system_score_gemma":0.00027817945,"threshold_uncertainty_score":0.010654807},"labels":[],"label_agreement":null},{"id":"W2174855058","doi":"10.1016/s0960-894x(03)00387-1","title":"Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Azetidine; Piperidine; Chemistry; Pyrrolidine; Agonist; Adrenergic receptor; Selectivity; Stereochemistry; Amine gas treating; BETA (programming language); Chemical synthesis; Receptor; Biochemistry; In vitro; Organic chemistry","score_opus":0.014690528677062484,"score_gpt":0.23889076455244215,"score_spread":0.22420023587537968,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2174855058","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9587498,0.012594242,0.0182074,0.00036963142,0.00014699993,0.0002212926,0.00027894246,0.00024286675,0.009188807],"genre_scores_gemma":[0.97131246,0.009982033,0.012745039,0.00024994143,0.000049375947,0.00013924105,0.0002786432,0.000039593873,0.0052036983],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999058,0.000024053295,0.000009539078,0.000013744095,0.00001978787,0.000027098864],"domain_scores_gemma":[0.99993086,0.000019148181,0.000021476342,0.000005486742,0.000007739532,0.000015322797],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00049079495,0.00038333784,0.00018662128,0.00017840615,0.00013085263,0.0002202075,0.0003625109,0.000340271,0.0011110129],"category_scores_gemma":[0.00021836217,0.00023704894,0.00018243531,0.00020646106,0.00023514705,0.0003523931,0.00026429453,0.00044266786,0.00038928346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00109929,0.0002571668,0.0005302634,0.0004379689,0.00004027099,0.00093781785,0.00038601184,0.0076113385,0.9175077,0.008752422,0.0008804847,0.061559226],"study_design_scores_gemma":[0.00042946948,0.00420769,0.0013479124,0.00007772746,0.00009440006,0.00091629935,0.00009323009,0.0054777255,0.94101936,0.0012039223,0.04507682,0.00005544389],"about_ca_topic_score_codex":0.0003914025,"about_ca_topic_score_gemma":0.0012649226,"teacher_disagreement_score":0.0011110129,"about_ca_system_score_codex":0.0003720736,"about_ca_system_score_gemma":0.00034673308,"threshold_uncertainty_score":0.0037166476},"labels":[],"label_agreement":null},{"id":"W2174996297","doi":"10.1016/j.bmcl.2005.03.093","title":"Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; 11β-hydroxysteroid dehydrogenase type 1; Hydroxysteroid dehydrogenase; Dehydrogenase; Enzyme; Biological activity; Biochemistry; Type 2 diabetes; Enzyme inhibitor; Metabolic pathway; Metabolic syndrome; Chemical synthesis; Pharmacology; Stereochemistry; In vitro; Diabetes mellitus; Endocrinology; Biology","score_opus":0.02931735420241064,"score_gpt":0.264080591185097,"score_spread":0.2347632369826864,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2174996297","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9743585,0.01233864,0.005984271,0.00030423052,0.00017579661,0.0002476606,0.0007455145,0.00012144856,0.0057240524],"genre_scores_gemma":[0.9833882,0.008872532,0.0032236197,0.000085466425,0.000037465354,0.00007942451,0.0007469533,0.00001382718,0.0035524906],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987924,0.000026754233,0.000015247606,0.000015606678,0.000026705467,0.00003638905],"domain_scores_gemma":[0.99990165,0.000014505386,0.00002129587,0.000009815173,0.000021229524,0.00003148779],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038140843,0.0005430034,0.000318987,0.00027615842,0.00022470648,0.00023201514,0.00042777843,0.00032150856,0.0013636363],"category_scores_gemma":[0.00022209807,0.00018598283,0.00029687444,0.00020565631,0.0002307442,0.00028624048,0.00018356793,0.0003509421,0.00036670823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010983874,0.00036456247,0.0004492362,0.0002442464,0.000046642548,0.0004933937,0.000120772675,0.0017325578,0.9765876,0.000959867,0.00060003187,0.017302725],"study_design_scores_gemma":[0.00036864547,0.004449148,0.0015490337,0.000016600456,0.00007410429,0.0005319398,0.000056075132,0.0010688929,0.9804622,0.00012577188,0.01127827,0.000019396188],"about_ca_topic_score_codex":0.0009260217,"about_ca_topic_score_gemma":0.0016302484,"teacher_disagreement_score":0.0013636363,"about_ca_system_score_codex":0.00034021342,"about_ca_system_score_gemma":0.00038509083,"threshold_uncertainty_score":0.0045618415},"labels":[],"label_agreement":null},{"id":"W2175128471","doi":"10.1016/s0960-894x(03)00510-9","title":"Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1–E2–Origin DNA complex","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; DNA; Human papillomavirus; Series (stratigraphy); Structure–activity relationship; Stereochemistry; In vitro; Combinatorial chemistry; Biochemistry","score_opus":0.03152733179759011,"score_gpt":0.2825992438841793,"score_spread":0.2510719120865892,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175128471","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.83336914,0.09090733,0.037302837,0.0020686924,0.0009792204,0.0018435847,0.0030271905,0.0011175072,0.029384421],"genre_scores_gemma":[0.91805565,0.04114708,0.01805789,0.0011536732,0.00019269796,0.00047336586,0.002446009,0.00011436721,0.01835911],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998318,0.000023712506,0.000011974174,0.000026829845,0.00004338883,0.00006231156],"domain_scores_gemma":[0.99984,0.000037210797,0.000031656444,0.00001489421,0.000026739637,0.000049390936],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033066745,0.0008582032,0.00072293077,0.00046785062,0.00031489276,0.0008011314,0.00065224495,0.0006388339,0.0023042876],"category_scores_gemma":[0.00042925985,0.00040420724,0.0004549766,0.00024835768,0.00028710198,0.00037211587,0.00039191116,0.0013800458,0.0006299687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014212166,0.0014327528,0.0013640025,0.0009976581,0.000319976,0.0008938013,0.00034639603,0.0037657616,0.86867684,0.004163027,0.0080593005,0.10855928],"study_design_scores_gemma":[0.0008359188,0.0043482445,0.0024317084,0.00006565706,0.00019838272,0.0012035728,0.00005012773,0.0027238645,0.90128195,0.0005537362,0.086244166,0.00006270552],"about_ca_topic_score_codex":0.00082756643,"about_ca_topic_score_gemma":0.0030462733,"teacher_disagreement_score":0.0023042876,"about_ca_system_score_codex":0.00074593123,"about_ca_system_score_gemma":0.00046078465,"threshold_uncertainty_score":0.007708609},"labels":[],"label_agreement":null},{"id":"W2175160998","doi":"10.1016/j.bmcl.2004.12.075","title":"Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Heme oxygenase; Isozyme; Heme; Stereochemistry; Oxygenase; Enzyme inhibitor; Enzyme; Biochemistry; Chemical synthesis; Structure–activity relationship; In vitro","score_opus":0.010940611405287504,"score_gpt":0.2468645139593898,"score_spread":0.23592390255410228,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175160998","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95393664,0.020283084,0.009539356,0.0006550275,0.00031105068,0.00072373747,0.0015355299,0.00025521213,0.012760315],"genre_scores_gemma":[0.9783478,0.010091559,0.0055900947,0.00013982409,0.000060310012,0.00014770706,0.0013307886,0.000025853733,0.0042661596],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988604,0.000027137743,0.0000133660815,0.000017955983,0.000026167994,0.000029300558],"domain_scores_gemma":[0.9999455,0.000009002804,0.000009453312,0.000006050021,0.000012657025,0.000017340903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028191632,0.00038185666,0.0005955356,0.00043492415,0.00031144285,0.00030638618,0.0005721625,0.00038011384,0.0019648466],"category_scores_gemma":[0.00021239913,0.00020626685,0.00028939225,0.00029172335,0.00020755155,0.00031157443,0.00018481418,0.0005793204,0.0004533339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019095318,0.00061610376,0.00026657546,0.00044875196,0.0000911369,0.00077857636,0.00012153179,0.0036808136,0.9551595,0.0015727646,0.0009832024,0.0343716],"study_design_scores_gemma":[0.0011510527,0.008194386,0.0014588485,0.000042680946,0.00020916338,0.0010199781,0.000040902694,0.0026804453,0.9624009,0.0002959358,0.022463115,0.00004255739],"about_ca_topic_score_codex":0.00062827,"about_ca_topic_score_gemma":0.0009913264,"teacher_disagreement_score":0.0019648466,"about_ca_system_score_codex":0.0003261303,"about_ca_system_score_gemma":0.00023385917,"threshold_uncertainty_score":0.0065730214},"labels":[],"label_agreement":null},{"id":"W2175256273","doi":"10.1016/s0960-894x(02)00739-4","title":"Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Lactone; Pharmacokinetics; Alkoxy group; Stereochemistry; Chemical synthesis; Enzyme inhibitor; Metabolism; Pharmacology; Biochemistry; In vitro; Organic chemistry","score_opus":0.006538567781633565,"score_gpt":0.19639199576606645,"score_spread":0.1898534279844329,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175256273","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96568507,0.0075879022,0.016429627,0.00058407115,0.00016196395,0.00035269224,0.0012160917,0.0002908872,0.0076916297],"genre_scores_gemma":[0.97758377,0.00461583,0.011746883,0.00021575834,0.00005064976,0.00012027752,0.0009413239,0.000032073287,0.0046933633],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991345,0.000012316955,0.000006261843,0.000012564054,0.000020124688,0.000035190285],"domain_scores_gemma":[0.9999294,0.000009717342,0.000012592157,0.0000061932637,0.000011288139,0.000030646555],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024500175,0.00050868036,0.0004150257,0.0003059562,0.00021964888,0.0003951152,0.00044023347,0.0003361731,0.0018707429],"category_scores_gemma":[0.00018333424,0.00017461025,0.000251708,0.00026027154,0.00023807728,0.00035105133,0.00030226423,0.000630296,0.00049838785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012413095,0.00037375352,0.00067162013,0.00019232671,0.000033240853,0.0010272113,0.00009695608,0.0016217504,0.96724105,0.0014744963,0.0007380037,0.025288267],"study_design_scores_gemma":[0.0005371774,0.005191182,0.0020752957,0.000024655124,0.00011314457,0.0011484006,0.000045994504,0.0017272268,0.9686413,0.00022819678,0.020230634,0.0000366924],"about_ca_topic_score_codex":0.0006772565,"about_ca_topic_score_gemma":0.002453386,"teacher_disagreement_score":0.0018707429,"about_ca_system_score_codex":0.00039883822,"about_ca_system_score_gemma":0.00058808445,"threshold_uncertainty_score":0.006258309},"labels":[],"label_agreement":null},{"id":"W2175272524","doi":"10.1016/s0960-894x(02)00946-0","title":"Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the ‘Distal binding pocket’","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Reactions of Organic Compounds","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McMaster University","keywords":"Chemistry; Thrombin; Acetamide; Discovery and development of direct thrombin inhibitors; Covalent bond; Stereochemistry; Intramolecular force; Hydrogen bond; Amide; Molecule; Non-covalent interactions; Biochemistry; Organic chemistry; Platelet","score_opus":0.01521333092241352,"score_gpt":0.20901092469870153,"score_spread":0.193797593776288,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175272524","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8533309,0.029871125,0.085739665,0.0013969608,0.0010441322,0.0005884936,0.0012954691,0.0018763567,0.024856882],"genre_scores_gemma":[0.9231906,0.0061349017,0.045889366,0.0013588468,0.00016730998,0.0003913531,0.0020822033,0.00017841435,0.020607047],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99966395,0.000054889064,0.000023616005,0.00008356758,0.000109906185,0.000064085216],"domain_scores_gemma":[0.9998293,0.00005469173,0.000033492473,0.000026273105,0.000012077477,0.000044188655],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054423115,0.0006132378,0.0008380469,0.00021671591,0.00028318053,0.0006085044,0.0013170682,0.0008135662,0.0033459808],"category_scores_gemma":[0.00039203805,0.00038861067,0.00030073134,0.00019498986,0.0005689407,0.00069479994,0.00053431,0.0013783062,0.0020882087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047646364,0.00012025044,0.00011743035,0.00017680004,0.000022224249,0.00015585608,0.000032667875,0.00034533103,0.98460567,0.0016087636,0.0009037424,0.011434953],"study_design_scores_gemma":[0.000321156,0.0009532168,0.0005006251,0.000010161524,0.000040253355,0.00067378307,0.000017532539,0.0010179332,0.97423697,0.0003748633,0.021824922,0.0000284984],"about_ca_topic_score_codex":0.00029932454,"about_ca_topic_score_gemma":0.0009435293,"teacher_disagreement_score":0.0033459808,"about_ca_system_score_codex":0.0004497208,"about_ca_system_score_gemma":0.00029086022,"threshold_uncertainty_score":0.011193395},"labels":[],"label_agreement":null},{"id":"W2175319049","doi":"10.1016/s0960-894x(02)00518-8","title":"Structure–Activity Relationship of Biaryl Acylsulfonamide Analogues on the Human EP3 Prostanoid Receptor","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Prostanoid; Chemistry; Receptor; Moiety; Chemical synthesis; Stereochemistry; Structure–activity relationship; Biochemistry; In vitro; Pharmacology; Combinatorial chemistry","score_opus":0.02516622063362908,"score_gpt":0.23618529156019613,"score_spread":0.21101907092656705,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175319049","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.996102,0.0020571284,0.00030632215,0.00007505745,0.000027707372,0.000024496108,0.00021724415,0.0000220488,0.0011681288],"genre_scores_gemma":[0.99512947,0.0022590437,0.00034954803,0.00007044132,0.000025377041,0.000025606167,0.0005209,0.0000054828074,0.0016140593],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999137,0.000023362536,0.000009497243,0.000008153459,0.000015529964,0.000029800289],"domain_scores_gemma":[0.9999026,0.00002787645,0.000023663672,0.0000081283,0.000013837613,0.000023844765],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251998,0.00026606407,0.0003164004,0.00019115042,0.00014497376,0.00016560018,0.00023573879,0.00020573869,0.002172794],"category_scores_gemma":[0.00023119699,0.00011813439,0.00023691272,0.00021306302,0.00016231566,0.00017806116,0.00012691336,0.00040303465,0.00035973254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0044300733,0.00032354426,0.0004648665,0.000099101504,0.000046990794,0.00027514968,0.00007370416,0.0008634807,0.9839166,0.00030378695,0.00033944534,0.008863152],"study_design_scores_gemma":[0.0014018049,0.02847205,0.01047211,0.00002443911,0.00028102417,0.0009943902,0.000115354414,0.0039373534,0.9464685,0.00014940945,0.0076439437,0.000039591567],"about_ca_topic_score_codex":0.0011894986,"about_ca_topic_score_gemma":0.0021463914,"teacher_disagreement_score":0.002172794,"about_ca_system_score_codex":0.00021298236,"about_ca_system_score_gemma":0.00017279253,"threshold_uncertainty_score":0.007268727},"labels":[],"label_agreement":null},{"id":"W2175533442","doi":"10.1016/s0960-894x(02)00679-0","title":"Novel nucleotide phosphonate analogues with potent antitumor activity","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Chemistry; Phosphonate; Nucleotide; In vitro; Stereochemistry; Chemical synthesis; Structure–activity relationship; Cell culture; Cancer cell lines; Biochemistry; Cancer cell; Cancer; Gene; Genetics; Biology","score_opus":0.013699799070449355,"score_gpt":0.21320415873586834,"score_spread":0.199504359665419,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175533442","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9524594,0.011046708,0.0091415895,0.0007021122,0.0006534053,0.0006216391,0.0017205467,0.0005705738,0.023084026],"genre_scores_gemma":[0.98251545,0.005118339,0.004910122,0.00027458786,0.00007270942,0.00018418717,0.0011753876,0.000052096264,0.005697115],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988735,0.000020148897,0.000014936238,0.000019811978,0.000024954137,0.000032878765],"domain_scores_gemma":[0.9999069,0.0000178927,0.000017784248,0.000010898979,0.000011561785,0.000034944285],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020057398,0.0005254115,0.0005398078,0.0003150513,0.00022761102,0.00043974695,0.0006471284,0.0005653519,0.0027943528],"category_scores_gemma":[0.00023048758,0.00030037572,0.00018501005,0.0003129289,0.00025151894,0.00035378465,0.00036830318,0.00086940965,0.00066241773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018616334,0.0002905816,0.000188166,0.0003757283,0.00003958946,0.0008218969,0.00010606336,0.002360375,0.95404214,0.0020833723,0.0010538932,0.036776546],"study_design_scores_gemma":[0.0013746393,0.006066859,0.001350511,0.00004126955,0.00011054948,0.0017884148,0.000031902928,0.0019690602,0.94485885,0.00048277693,0.041862726,0.00006252691],"about_ca_topic_score_codex":0.0006227882,"about_ca_topic_score_gemma":0.0009993088,"teacher_disagreement_score":0.0027943528,"about_ca_system_score_codex":0.00035538964,"about_ca_system_score_gemma":0.00028855004,"threshold_uncertainty_score":0.009348035},"labels":[],"label_agreement":null},{"id":"W2175554357","doi":"10.1016/j.bmcl.2003.09.089","title":"The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Steroid sulfatase; Steroid; Chemistry; Estrone sulfate; Sulfate; Estrone; Alpha (finance); Stereochemistry; Substrate (aquarium); Biochemistry; Organic chemistry; Hormone","score_opus":0.008189699389703611,"score_gpt":0.2330911551462962,"score_spread":0.2249014557565926,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175554357","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.891019,0.019025939,0.05548996,0.002915055,0.0010189646,0.00037420855,0.00086108566,0.0005567981,0.028738983],"genre_scores_gemma":[0.9481223,0.018528638,0.017917767,0.00076475187,0.00030588685,0.00015657223,0.0005430464,0.00006593243,0.013595154],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991524,0.000012677552,0.0000073061324,0.000013880293,0.000018748933,0.000032166092],"domain_scores_gemma":[0.9999565,0.0000072998173,0.000010163346,0.000008239567,0.000006594798,0.0000113016295],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003230827,0.00049139786,0.0003900208,0.0003153873,0.00034831374,0.0002353406,0.0008476409,0.0005058219,0.00178378],"category_scores_gemma":[0.0001477077,0.00017898956,0.00033553335,0.00022535767,0.00035830066,0.0006690048,0.00034454282,0.0005892096,0.00045246613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013310668,0.00030084705,0.00038058535,0.00034104584,0.000039739753,0.000989952,0.00021467009,0.0016277549,0.9108797,0.015227291,0.0023915165,0.06627594],"study_design_scores_gemma":[0.000508534,0.0050342083,0.00095085613,0.00005018553,0.00011291356,0.0016069543,0.000087461536,0.0020512869,0.89900994,0.0018469462,0.088665366,0.00007526509],"about_ca_topic_score_codex":0.0008429848,"about_ca_topic_score_gemma":0.0011032993,"teacher_disagreement_score":0.00178378,"about_ca_system_score_codex":0.00029613494,"about_ca_system_score_gemma":0.00039638262,"threshold_uncertainty_score":0.0059673786},"labels":[],"label_agreement":null},{"id":"W2175799135","doi":"10.1016/j.bmcl.2015.10.015","title":"A selective inhibitor of the UFM1-activating enzyme, UBA5","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; National Institutes of Health","keywords":"Chemistry; Enzyme; Enzyme inhibitor; Stereochemistry; Biochemistry; Structure–activity relationship; In vitro","score_opus":0.016547662386473722,"score_gpt":0.2288560653593564,"score_spread":0.21230840297288267,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175799135","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92581564,0.03629481,0.013664938,0.0010478391,0.0006823499,0.00023382007,0.0017777997,0.0009966905,0.019486045],"genre_scores_gemma":[0.9848483,0.0054763015,0.004005606,0.00023524105,0.000038393257,0.000058115904,0.00106119,0.000018020062,0.004258847],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998741,0.000012456758,0.00001038477,0.000029275854,0.000028032411,0.000045707504],"domain_scores_gemma":[0.9999585,0.000007514435,0.000007913728,0.000005227882,0.00000544382,0.000015339245],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021014964,0.0004900101,0.0004378842,0.00030506405,0.00028319727,0.00032840198,0.00056927075,0.00041935916,0.001972609],"category_scores_gemma":[0.00013067033,0.00015725486,0.00031080068,0.00025419833,0.00017047017,0.00026072655,0.000186906,0.00060561235,0.00052447163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009251669,0.00020674295,0.00028526745,0.00030625693,0.00008182868,0.00025879272,0.000028066015,0.00043842886,0.9712469,0.0017563683,0.0019046407,0.022561429],"study_design_scores_gemma":[0.00013250287,0.00061925367,0.00093663647,0.000012531925,0.000056926478,0.00061188365,0.00001691409,0.001470766,0.98366714,0.00012227814,0.012341772,0.000011440074],"about_ca_topic_score_codex":0.0008143204,"about_ca_topic_score_gemma":0.0017646294,"teacher_disagreement_score":0.001972609,"about_ca_system_score_codex":0.0007200183,"about_ca_system_score_gemma":0.0004099872,"threshold_uncertainty_score":0.0065990686},"labels":[],"label_agreement":null},{"id":"W2175841092","doi":"10.1016/j.bmcl.2003.09.058","title":"Lysine sulfonamides as novel HIV-Protease inhibitors: optimization of the Nε -acyl-phenyl spacer","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SNC-Lavalin (Canada)","funders":"","keywords":"Chemistry; Lysine; Protease; Sulfonamide; Enzyme inhibitor; Human immunodeficiency virus (HIV); Stereochemistry; Enzyme; Protease inhibitor (pharmacology); Chemical synthesis; HIV-1 protease; Biochemistry; Combinatorial chemistry; In vitro; Virology; Amino acid","score_opus":0.008609353486990216,"score_gpt":0.21671591386853117,"score_spread":0.20810656038154096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175841092","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9836602,0.0037786306,0.007337564,0.00014312305,0.00005336756,0.000099260484,0.00014868766,0.000115030896,0.0046641976],"genre_scores_gemma":[0.98997587,0.0025818276,0.0054420764,0.00007501447,0.000017544642,0.000042524593,0.000109240376,0.000016105258,0.0017397488],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998828,0.000031395262,0.000011675011,0.000017718035,0.000025662708,0.000030764484],"domain_scores_gemma":[0.9999182,0.000018703808,0.000027086902,0.0000065596705,0.000009011973,0.00002037207],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033274476,0.00051290845,0.00034316813,0.00013775863,0.00015529583,0.00027932142,0.00039230683,0.00028638053,0.0010402928],"category_scores_gemma":[0.00018398007,0.00018609282,0.0001686325,0.00014800546,0.00023302717,0.00034426487,0.00022586685,0.0003884499,0.0003457097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010871368,0.00016903997,0.00025432403,0.00016390417,0.000020115302,0.0004193055,0.00006158411,0.0029514686,0.97698224,0.0015230504,0.0001835407,0.016184315],"study_design_scores_gemma":[0.00033922764,0.0026773012,0.0006760064,0.000017761597,0.000048540445,0.00039046945,0.000031329517,0.0033553638,0.9853183,0.00020459009,0.0069166045,0.000024593495],"about_ca_topic_score_codex":0.0004671757,"about_ca_topic_score_gemma":0.0009845447,"teacher_disagreement_score":0.0010402928,"about_ca_system_score_codex":0.0003318109,"about_ca_system_score_gemma":0.0003125997,"threshold_uncertainty_score":0.0034800768},"labels":[],"label_agreement":null},{"id":"W2175894158","doi":"10.1016/j.bmcl.2006.01.033","title":"The geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer’s disease modifying agent","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Flurbiprofen; Chemistry; Geminal; Cyclooxygenase; Pharmacology; In vitro; Alzheimer's disease; Stereochemistry; Disease; Biochemistry; Enzyme; Internal medicine; Medicine","score_opus":0.018500228533322668,"score_gpt":0.2715866230076668,"score_spread":0.2530863944743441,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175894158","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98303944,0.006691693,0.0029692252,0.00036172668,0.00012853055,0.00006859527,0.0002563598,0.00013066048,0.0063536707],"genre_scores_gemma":[0.9949366,0.0016453487,0.0014971138,0.0000969198,0.000026012302,0.000011546181,0.00019900104,0.0000073112624,0.0015801291],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999343,0.000012562962,0.000004640032,0.000010688426,0.000009616267,0.000028118362],"domain_scores_gemma":[0.99997425,0.0000035252197,0.0000050831754,0.0000032391092,0.0000032319138,0.000010633624],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022864834,0.00023947693,0.0002648813,0.00019139737,0.00021283115,0.0001804549,0.00051751017,0.0003613824,0.00095637684],"category_scores_gemma":[0.00011450838,0.000115921765,0.00015097584,0.00014130957,0.0002029461,0.0003158877,0.00013501105,0.0003378873,0.00021903214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0054371473,0.00023908225,0.00038108733,0.00016724538,0.000044641467,0.0010847411,0.00010351378,0.001193789,0.95548546,0.0021444117,0.0011347827,0.032584123],"study_design_scores_gemma":[0.0012352093,0.009145747,0.0038166654,0.00002606786,0.00015933785,0.0027656495,0.00007083486,0.0035552238,0.949092,0.00039349718,0.029690258,0.000049655468],"about_ca_topic_score_codex":0.0010210868,"about_ca_topic_score_gemma":0.0010622507,"teacher_disagreement_score":0.0010210868,"about_ca_system_score_codex":0.00023913263,"about_ca_system_score_gemma":0.00017683145,"threshold_uncertainty_score":0.0031994581},"labels":[],"label_agreement":null},{"id":"W2176025995","doi":"10.1016/j.bmcl.2004.07.001","title":"Synthesis of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Benzodiazepine; Ring (chemistry); Stereochemistry; DNA; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor","score_opus":0.014802109695932271,"score_gpt":0.21690018533970715,"score_spread":0.20209807564377488,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176025995","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92269117,0.007565247,0.053421177,0.0005822598,0.00030370167,0.00034858758,0.0008619266,0.0007526982,0.01347323],"genre_scores_gemma":[0.961384,0.0019842002,0.02517685,0.00017406985,0.00003930204,0.000115792405,0.0007745333,0.00003725879,0.01031398],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999095,0.000013458349,0.0000071126697,0.000024285333,0.000016791506,0.000028762364],"domain_scores_gemma":[0.9999459,0.000005159283,0.000013850543,0.0000053215485,0.000008920853,0.00002084335],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438962,0.00024711434,0.0003003402,0.00016799824,0.00029186244,0.00024559043,0.0005848985,0.0003442414,0.002141499],"category_scores_gemma":[0.00012474325,0.00015906063,0.00018631795,0.00016018799,0.0001753604,0.00024685552,0.00022266545,0.00032724094,0.0008539968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009445228,0.00004280128,0.00006304569,0.00013858135,0.000011112139,0.00017782424,0.000052359217,0.00032003512,0.9914643,0.0008752641,0.0002259207,0.0065342598],"study_design_scores_gemma":[0.000084727886,0.0008704753,0.0006167869,0.000010580582,0.000031989435,0.0004792829,0.00001925731,0.00083344406,0.973781,0.00016032976,0.023085255,0.000026842203],"about_ca_topic_score_codex":0.00078109844,"about_ca_topic_score_gemma":0.0014220272,"teacher_disagreement_score":0.002141499,"about_ca_system_score_codex":0.00039278265,"about_ca_system_score_gemma":0.00048651453,"threshold_uncertainty_score":0.007164061},"labels":[],"label_agreement":null},{"id":"W2176098424","doi":"10.1016/j.bmcl.2004.11.021","title":"4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonists","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Chemistry; Piperazine; TRPV1; Antagonist; IC50; Benzimidazole; Capsaicin; Stereochemistry; Pharmacology; In vitro; Biochemistry; Receptor; Transient receptor potential channel; Organic chemistry","score_opus":0.01380697168275361,"score_gpt":0.23789427081205872,"score_spread":0.2240872991293051,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176098424","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8698257,0.08187759,0.013263503,0.0018121175,0.0007944126,0.00034864733,0.0010476027,0.000840426,0.030190084],"genre_scores_gemma":[0.9504445,0.031500172,0.0040865922,0.0004173513,0.0001743102,0.0001405447,0.0008211275,0.00004295607,0.012372598],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998491,0.00003132763,0.0000085886595,0.00001595597,0.00003159065,0.00006339288],"domain_scores_gemma":[0.9999523,0.0000106156585,0.000011482402,0.000003932442,0.000006762618,0.00001488174],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027784414,0.00042049022,0.00048187957,0.0003313039,0.00027168303,0.00030441096,0.00056386314,0.00036103357,0.0033273818],"category_scores_gemma":[0.00020869338,0.0002328859,0.00017646728,0.0002820771,0.00022892778,0.00037631992,0.00027168303,0.0009888875,0.0007825404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013312955,0.0002467595,0.00020750817,0.0005678168,0.000029266092,0.00029665045,0.00014289301,0.0011059837,0.95266753,0.0032436764,0.0027290643,0.037431493],"study_design_scores_gemma":[0.0018476079,0.011694694,0.009034231,0.00017476783,0.00022513967,0.0020898718,0.00013921646,0.0054476657,0.85326684,0.0012210568,0.11475218,0.00010687144],"about_ca_topic_score_codex":0.00082016725,"about_ca_topic_score_gemma":0.0040861093,"teacher_disagreement_score":0.0033273818,"about_ca_system_score_codex":0.00044020952,"about_ca_system_score_gemma":0.0002928444,"threshold_uncertainty_score":0.011131167},"labels":[],"label_agreement":null},{"id":"W2176180504","doi":"10.1016/j.bmcl.2015.11.096","title":"Anti-inflammatory properties of quebecol and its derivatives","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Plant-Derived Bioactive Compounds","field":"Chemistry","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Chemistry; Anti-inflammatory; Moiety; Structure–activity relationship; Polyphenol; Stereochemistry; Secretion; Inflammation; Proinflammatory cytokine; Biological activity; Biochemistry; In vitro; Pharmacology; Immunology; Antioxidant","score_opus":0.03055043534710578,"score_gpt":0.21576587695280125,"score_spread":0.18521544160569547,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176180504","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95236534,0.016817093,0.00066653435,0.00040173501,0.00010117166,0.00008865073,0.0013190348,0.000048817903,0.028191745],"genre_scores_gemma":[0.97742987,0.0037764595,0.0006104015,0.00014370383,0.00001817589,0.000016812515,0.0004964943,0.000006277563,0.017501827],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995255,0.000010222436,0.0000020061461,0.000005100586,0.000008158676,0.000022045702],"domain_scores_gemma":[0.99994564,0.000007747222,0.0000067044707,0.0000038107407,0.00001959639,0.000016562672],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000906134,0.00022741385,0.000125504,0.00035397525,0.00037812334,0.00025160794,0.0002858584,0.00021777416,0.00786385],"category_scores_gemma":[0.00014188692,0.00006196984,0.000121836274,0.00029890848,0.00020033144,0.00015280768,0.00009575517,0.00032696465,0.0003861486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003690546,0.0002328455,0.0018008021,0.00058236223,0.000050296614,0.00068231946,0.00027903036,0.0011822631,0.9278196,0.002311471,0.002360957,0.059007555],"study_design_scores_gemma":[0.00031127,0.005666373,0.03940312,0.00013861877,0.0001797021,0.0005028022,0.0005079286,0.0020654658,0.83792704,0.00029990263,0.1129095,0.00008822984],"about_ca_topic_score_codex":0.1976136,"about_ca_topic_score_gemma":0.3059888,"teacher_disagreement_score":0.1976136,"about_ca_system_score_codex":0.00095935474,"about_ca_system_score_gemma":0.00094297575,"threshold_uncertainty_score":0.3929267},"labels":[],"label_agreement":null},{"id":"W2176195848","doi":"10.1016/s0960-894x(02)00303-7","title":"Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Metabolite; Chemistry; In vivo; Antagonist; Pharmacology; Angiotensin II; Active metabolite; Renin–angiotensin system; Receptor antagonist; Receptor; Endocrinology; Biochemistry; Blood pressure; Medicine; Biology","score_opus":0.011202885527761169,"score_gpt":0.2173492214301445,"score_spread":0.20614633590238335,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176195848","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97516483,0.015127157,0.0044708285,0.00030514595,0.00013302482,0.00009903644,0.0005650064,0.00008941704,0.0040455996],"genre_scores_gemma":[0.9898996,0.0050667236,0.0020176265,0.00012446908,0.000045222932,0.000028362281,0.00051258615,0.000011433297,0.0022940137],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999474,0.000018275983,0.0000039692527,0.0000063473008,0.000009726399,0.000014266277],"domain_scores_gemma":[0.9999505,0.000009396257,0.0000115147095,0.000005432953,0.0000050861686,0.00001800107],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012647723,0.0002912484,0.00021574012,0.00018186182,0.00013007436,0.00019582345,0.00020154209,0.00023026708,0.002000679],"category_scores_gemma":[0.00017350311,0.00016304285,0.00021850773,0.00011941761,0.00019187773,0.00023752701,0.00014804004,0.00045619067,0.00037230694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0065679774,0.00021881807,0.00078909437,0.00017636351,0.00009079436,0.0015988909,0.000113129114,0.0006639669,0.9573962,0.0015205557,0.00046030144,0.030403918],"study_design_scores_gemma":[0.0005128919,0.0065859808,0.005808182,0.000023202434,0.00022196335,0.0032844734,0.00007781599,0.0016365739,0.963194,0.00067947793,0.017942684,0.000032693883],"about_ca_topic_score_codex":0.0004276251,"about_ca_topic_score_gemma":0.0006945066,"teacher_disagreement_score":0.002000679,"about_ca_system_score_codex":0.0001964492,"about_ca_system_score_gemma":0.00024396424,"threshold_uncertainty_score":0.006692946},"labels":[],"label_agreement":null},{"id":"W2176205167","doi":"10.1016/j.bmcl.2005.03.058","title":"4-Alkyl and 4,4′-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Biosynthesis; Alkyl; Chemical synthesis; Stereochemistry; In vitro; Combinatorial chemistry; Biochemistry; Organic chemistry; Enzyme","score_opus":0.005829401805118546,"score_gpt":0.2003465491571208,"score_spread":0.19451714735200226,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176205167","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93767726,0.03043441,0.014227662,0.00076415815,0.00044089239,0.00017195198,0.00071611826,0.0008937902,0.014673754],"genre_scores_gemma":[0.9736232,0.010836367,0.006125731,0.00025311197,0.00006387709,0.00016050907,0.00043687073,0.000054611497,0.008445837],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985015,0.000032542262,0.000011016568,0.000017262477,0.000030827883,0.000058221423],"domain_scores_gemma":[0.999928,0.000015170865,0.000019917816,0.0000065493273,0.000009429537,0.000021004247],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026194373,0.00052202726,0.00057615223,0.0003351641,0.00019509606,0.00030683458,0.00062670227,0.00039161355,0.001615013],"category_scores_gemma":[0.00016948799,0.00027385898,0.00023039136,0.00023876766,0.00028447155,0.00028244362,0.0003066793,0.0007397354,0.00053193537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006836295,0.00013365077,0.00014360118,0.0002175121,0.000015357786,0.00020150644,0.00007464183,0.0008394976,0.9808791,0.0016649644,0.00062539947,0.014521164],"study_design_scores_gemma":[0.000514688,0.0022448844,0.002805379,0.000032380685,0.00005992684,0.00054083223,0.000042242926,0.0036477395,0.9689295,0.0003033484,0.020831188,0.000047812624],"about_ca_topic_score_codex":0.000819134,"about_ca_topic_score_gemma":0.0018489391,"teacher_disagreement_score":0.001615013,"about_ca_system_score_codex":0.00050155446,"about_ca_system_score_gemma":0.00033794157,"threshold_uncertainty_score":0.005402744},"labels":[],"label_agreement":null},{"id":"W2176244692","doi":"10.1016/j.bmcl.2004.01.076","title":"Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Rofecoxib; Chemistry; Cyclooxygenase; Enzyme inhibitor; Prostaglandin-Endoperoxide Synthase; Stereochemistry; Pharmacology; In vitro; Biochemistry; Enzyme","score_opus":0.005375378291756762,"score_gpt":0.21188305712454064,"score_spread":0.20650767883278387,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176244692","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9884277,0.0041593364,0.0013793502,0.00021239332,0.00012900012,0.0000676793,0.00044748263,0.00010037747,0.0050767367],"genre_scores_gemma":[0.9936419,0.0017402463,0.0015357562,0.0000678923,0.00006158504,0.00004072138,0.00045944078,0.000006540584,0.0024458496],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998815,0.000024873922,0.000012800871,0.000012602245,0.00003252433,0.00003574716],"domain_scores_gemma":[0.9999181,0.0000098774035,0.000023425644,0.000008993941,0.000008804049,0.00003073073],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019821992,0.00025718563,0.0003089336,0.0002044537,0.00014622799,0.00016951708,0.00031927146,0.00022406552,0.0013946268],"category_scores_gemma":[0.00016110063,0.000107505984,0.0001689125,0.00013884343,0.00024130526,0.00017653899,0.000117132935,0.00035142756,0.00036598198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001413381,0.00016204972,0.00044443947,0.000083177736,0.000023870078,0.0003056058,0.000042151096,0.00046544906,0.98227143,0.0008216922,0.0005461282,0.013420699],"study_design_scores_gemma":[0.0007822987,0.0068908962,0.006939245,0.000012264426,0.00007002753,0.0017748844,0.000049996997,0.0018006748,0.9589886,0.00014036696,0.022525249,0.000025428142],"about_ca_topic_score_codex":0.0007271982,"about_ca_topic_score_gemma":0.0014758685,"teacher_disagreement_score":0.0013946268,"about_ca_system_score_codex":0.00021041848,"about_ca_system_score_gemma":0.00028033173,"threshold_uncertainty_score":0.004665494},"labels":[],"label_agreement":null},{"id":"W2176270777","doi":"10.1016/j.bmcl.2004.07.025","title":"Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Neurite; Promoter; Kinase; Chemical synthesis; Stereochemistry; Enzyme inhibitor; Biochemistry; Enzyme; In vitro; Gene; Gene expression","score_opus":0.008105382290701369,"score_gpt":0.22772576790870502,"score_spread":0.21962038561800365,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176270777","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9691329,0.009554831,0.0077479132,0.000221879,0.00013877856,0.00034272848,0.0005367913,0.00019228287,0.012131854],"genre_scores_gemma":[0.9785952,0.0071788076,0.006329653,0.000069096015,0.000049136925,0.00019265902,0.00056679826,0.000035041143,0.00698359],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998276,0.000040009974,0.00001738023,0.000023074477,0.000046440542,0.0000453487],"domain_scores_gemma":[0.99988174,0.000021063874,0.00003432075,0.000014781005,0.000022640304,0.000025456415],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026506395,0.00032759615,0.00033373854,0.00024588284,0.00023041508,0.0002352282,0.00036577074,0.00023634486,0.001672255],"category_scores_gemma":[0.00024946622,0.00017787196,0.00025155034,0.00019995835,0.00019543545,0.00021982213,0.00018276453,0.000360709,0.0005288079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036885202,0.00012696671,0.00008448044,0.00017863985,0.000007661681,0.00021996979,0.000050230166,0.00058305345,0.9890499,0.00040973315,0.00018545036,0.008735178],"study_design_scores_gemma":[0.00008598382,0.0009819178,0.00073402526,0.000012954902,0.000019588422,0.00022665127,0.000015766016,0.0004973634,0.99132854,0.00003072826,0.0060533797,0.00001313152],"about_ca_topic_score_codex":0.0010571902,"about_ca_topic_score_gemma":0.0020909181,"teacher_disagreement_score":0.001672255,"about_ca_system_score_codex":0.0003577,"about_ca_system_score_gemma":0.0004272364,"threshold_uncertainty_score":0.005594313},"labels":[],"label_agreement":null},{"id":"W2176396060","doi":"10.1016/j.bmcl.2003.09.036","title":"β-Alanine dipeptides as MC4R agonists","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Alanine; Dipeptide; Stereochemistry; Derivative (finance); IC50; Pharmacology; Agonist; Structure–activity relationship; Chemical synthesis; Biochemistry; In vitro; Peptide; Amino acid; Receptor","score_opus":0.00800327464826874,"score_gpt":0.23299201760287502,"score_spread":0.22498874295460627,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176396060","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93111867,0.041888777,0.0048096706,0.0006232875,0.00044256353,0.00015557888,0.0003880112,0.0001937267,0.020379804],"genre_scores_gemma":[0.9700959,0.012539577,0.004186236,0.00033531126,0.000081031416,0.00006617977,0.00023525141,0.000024662824,0.01243589],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998901,0.00004397873,0.0000059959016,0.000012277216,0.00001969916,0.000027964661],"domain_scores_gemma":[0.9999547,0.000015618234,0.000005814885,0.0000039287215,0.000006682266,0.000013254113],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022686204,0.00028386657,0.00024281163,0.00027150568,0.00015557151,0.00032146534,0.00032292193,0.0002580005,0.0028051347],"category_scores_gemma":[0.00016402382,0.00018095682,0.00012825121,0.00012650763,0.00015178345,0.00022975214,0.00020452874,0.00048446146,0.0007478067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015837144,0.000087462264,0.00017327341,0.00022474561,0.000019125342,0.00031622118,0.00005793497,0.00037686262,0.96185756,0.0012683781,0.00073134794,0.03330325],"study_design_scores_gemma":[0.00018680927,0.0018202221,0.0007806796,0.000025715088,0.000040923762,0.000488998,0.00005412482,0.0008797525,0.9784025,0.00021823915,0.017085811,0.00001613858],"about_ca_topic_score_codex":0.00035097272,"about_ca_topic_score_gemma":0.00075258466,"teacher_disagreement_score":0.0028051347,"about_ca_system_score_codex":0.00018155445,"about_ca_system_score_gemma":0.00009426267,"threshold_uncertainty_score":0.009384155},"labels":[],"label_agreement":null},{"id":"W2176423804","doi":"10.1016/j.bmcl.2004.04.072","title":"Synthesis of S-alkyl l-homocysteine analogues of glutathione and their kinetic studies with γ-glutamyl transpeptidase","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Glutathione; Alkyl; Enzyme; Selectivity; Homocysteine; Biochemistry; Stereochemistry; Sulfur; Chemical synthesis; Organic chemistry; In vitro; Catalysis","score_opus":0.01123025841015444,"score_gpt":0.2266262730048425,"score_spread":0.21539601459468807,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176423804","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9927771,0.0012332059,0.0047135656,0.000049834623,0.000020257003,0.00003952347,0.00021016346,0.00004789506,0.00090845226],"genre_scores_gemma":[0.99365705,0.00058112055,0.0041430634,0.00001571369,0.0000054022817,0.00001916812,0.00032061076,0.00002013541,0.0012377133],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99977463,0.00008117464,0.000032581043,0.000029841245,0.000035143643,0.00004668804],"domain_scores_gemma":[0.9997603,0.00005473998,0.000055010227,0.000036239624,0.000048460643,0.000045153578],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044819678,0.00033033913,0.00046767274,0.00018894748,0.00016980099,0.0003069993,0.0003664641,0.00041490266,0.0007616379],"category_scores_gemma":[0.00056188344,0.00018636805,0.00035925081,0.00035906286,0.00018074093,0.00035955338,0.00022484236,0.0005267105,0.00034189638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000909274,0.00010607901,0.0003838527,0.0001424297,0.00005558272,0.00026134148,0.00016771648,0.0012947087,0.98990977,0.00065854995,0.000110907225,0.0059998953],"study_design_scores_gemma":[0.000030924617,0.0005901892,0.0003860456,0.0000038703965,0.000026061436,0.0001352557,0.000023739778,0.00066352834,0.9967636,0.000055835877,0.0013094806,0.000011565331],"about_ca_topic_score_codex":0.00079607154,"about_ca_topic_score_gemma":0.0008464193,"teacher_disagreement_score":0.00079607154,"about_ca_system_score_codex":0.0004241204,"about_ca_system_score_gemma":0.00028794355,"threshold_uncertainty_score":0.003077209},"labels":[],"label_agreement":null},{"id":"W2176546276","doi":"10.1016/j.bmcl.2005.08.036","title":"Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; In vivo; Bronchoconstriction; Pharmacology; In vitro; Ovalbumin; Structure–activity relationship; Biological activity; Enzyme inhibitor; Biochemistry; Internal medicine; Immunology; Medicine; Asthma; Biology; Immune system","score_opus":0.005202169468008323,"score_gpt":0.20060075336117186,"score_spread":0.19539858389316353,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2176546276","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96132064,0.0077837305,0.02345191,0.00052611355,0.00010297934,0.0003173282,0.00068548904,0.00029772098,0.005513964],"genre_scores_gemma":[0.9695394,0.0042783073,0.018174585,0.0002569838,0.000035648172,0.0001027424,0.0010744698,0.000042881886,0.0064950464],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998274,0.000038637016,0.000013523823,0.000023710298,0.000051263596,0.00004546275],"domain_scores_gemma":[0.9999068,0.000013634783,0.000020885953,0.00000840162,0.000027866996,0.00002242698],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046677,0.00039270404,0.00049876334,0.00025998533,0.00019009404,0.00025139906,0.00070903293,0.00029573342,0.0014230887],"category_scores_gemma":[0.00022740605,0.00020122911,0.00029019295,0.00017965914,0.00020347662,0.00022886338,0.00025154438,0.000612531,0.000374481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00041312427,0.00034501698,0.00035291366,0.00013859523,0.00003587881,0.00033002396,0.00008075351,0.0018040673,0.97971636,0.0008318475,0.000473676,0.0154777495],"study_design_scores_gemma":[0.00062111014,0.007310402,0.0034063836,0.000027299382,0.00014597508,0.0012243671,0.000054788707,0.005458695,0.96308994,0.00024405555,0.018370112,0.000046880432],"about_ca_topic_score_codex":0.0009972769,"about_ca_topic_score_gemma":0.0033711737,"teacher_disagreement_score":0.0014230887,"about_ca_system_score_codex":0.00041069978,"about_ca_system_score_gemma":0.0003886266,"threshold_uncertainty_score":0.004760742},"labels":[],"label_agreement":null},{"id":"W2177033145","doi":"10.1016/s0960-894x(03)00046-5","title":"3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Cyclooxygenase; Solubility; Potency; Aqueous solution; Combinatorial chemistry; Chemical synthesis; Molecule; Sodium; Organic chemistry; Stereochemistry; Pharmacology; Enzyme; In vitro; Biochemistry","score_opus":0.004258882110127355,"score_gpt":0.19583989323766102,"score_spread":0.19158101112753367,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2177033145","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9102039,0.037083074,0.03438708,0.0008650741,0.00032335386,0.00026457701,0.00091319205,0.0007375938,0.015222198],"genre_scores_gemma":[0.96833515,0.01408596,0.0063922605,0.00021578562,0.00011886325,0.00013727264,0.00050202984,0.000042183445,0.010170454],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990857,0.00001624928,0.0000061849537,0.000013049169,0.000023257158,0.000032720247],"domain_scores_gemma":[0.99994683,0.0000151293225,0.0000142319295,0.0000048825405,0.000006954336,0.000012077006],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754033,0.00044506695,0.0003352424,0.00024617603,0.00014842421,0.00020885501,0.00034350838,0.00027845515,0.0016925635],"category_scores_gemma":[0.00015000867,0.00025766177,0.00017177043,0.00019029625,0.00019083392,0.00050299504,0.00032027843,0.0004932203,0.000649337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00051331666,0.000106762396,0.0000805473,0.00018116456,0.000012755802,0.00016667649,0.00007949593,0.0005932797,0.97588843,0.0014415219,0.0007420206,0.020193996],"study_design_scores_gemma":[0.00019349897,0.0011627806,0.00048875686,0.000012333918,0.000020957767,0.00026070833,0.000016410513,0.0009965333,0.98345804,0.00016780247,0.013209972,0.000012225396],"about_ca_topic_score_codex":0.0003124713,"about_ca_topic_score_gemma":0.0007623157,"teacher_disagreement_score":0.0016925635,"about_ca_system_score_codex":0.00022189866,"about_ca_system_score_gemma":0.00016696357,"threshold_uncertainty_score":0.005662203},"labels":[],"label_agreement":null},{"id":"W2177096160","doi":"10.1016/j.bmcl.2003.10.068","title":"Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Subgenomic mRNA; NS5B; Chemistry; Polymerase; Hepatitis C virus; Virology; RNA polymerase; RNA-dependent RNA polymerase; Enzyme; Virus; RNA; Hepacivirus; Biochemistry; Biology; Gene","score_opus":0.012011522077873425,"score_gpt":0.2571372446555651,"score_spread":0.24512572257769166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2177096160","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96310365,0.014135032,0.010296875,0.00041939708,0.00016048609,0.00041249563,0.00047778513,0.00012577683,0.010868477],"genre_scores_gemma":[0.9726398,0.013246575,0.0061877384,0.00021517242,0.00008999205,0.00015653648,0.0005019398,0.000021934338,0.0069403285],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992275,0.000020275524,0.000004502602,0.000007987796,0.000019296567,0.000025180316],"domain_scores_gemma":[0.9999281,0.0000142386,0.000013243677,0.000008330742,0.00001448288,0.00002168125],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003755841,0.0004921132,0.00029060352,0.00027147512,0.00012307648,0.00026191075,0.00025980247,0.00027549284,0.0021217503],"category_scores_gemma":[0.00022289572,0.00016324321,0.00027501365,0.00015449473,0.00018872996,0.00020544758,0.00020861242,0.0003824809,0.00047854168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00061762164,0.00014564929,0.00019722423,0.00018232815,0.000028876499,0.00029272653,0.00004928335,0.0014946325,0.9667553,0.0009132907,0.00051529275,0.028807838],"study_design_scores_gemma":[0.0004857301,0.0036366987,0.00170464,0.000023800576,0.000058070094,0.000520431,0.000021916123,0.0018736017,0.97802895,0.00027864292,0.013347598,0.000019992116],"about_ca_topic_score_codex":0.0002865007,"about_ca_topic_score_gemma":0.000822502,"teacher_disagreement_score":0.0021217503,"about_ca_system_score_codex":0.0001864484,"about_ca_system_score_gemma":0.00023240855,"threshold_uncertainty_score":0.0070979595},"labels":[],"label_agreement":null},{"id":"W2177323728","doi":"10.1016/s0960-894x(03)00042-8","title":"Discovery of a potent and selective agonist of the prostaglandin EP4 receptor","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Agonist; Prostaglandin E2 receptor; Receptor; Potency; Prostaglandin; Pharmacology; Stereochemistry; Chemical synthesis; Biochemistry; In vitro; Medicine","score_opus":0.005161414637041062,"score_gpt":0.20170754477988154,"score_spread":0.19654613014284048,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2177323728","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93647003,0.014119724,0.030254805,0.0025466576,0.00042401644,0.00041121512,0.0012720367,0.00037238759,0.0141291125],"genre_scores_gemma":[0.95986766,0.008181633,0.014191104,0.00091736176,0.0001517362,0.00014513968,0.0015813892,0.000041891453,0.014922053],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998982,0.00001720857,0.000005666801,0.000014186276,0.00002401147,0.000040690575],"domain_scores_gemma":[0.99995005,0.000010516582,0.0000067801802,0.000005193515,0.0000087331655,0.000018725963],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026822468,0.00036299977,0.00041129783,0.00033713563,0.0002538585,0.00040968557,0.0005284184,0.00046542904,0.0027644536],"category_scores_gemma":[0.0002538348,0.00023693754,0.00028790126,0.00013467186,0.00022123384,0.00029017025,0.00040691352,0.00075646816,0.0008531822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046097848,0.00015920147,0.0002489728,0.0001316774,0.00003406212,0.0006966664,0.000050811395,0.00037920795,0.9706896,0.001194645,0.0013521578,0.024602098],"study_design_scores_gemma":[0.00034624455,0.0026285078,0.0019415459,0.000023692366,0.000111737194,0.0028428049,0.000062544,0.0015758786,0.9448422,0.00058061694,0.045008536,0.00003566621],"about_ca_topic_score_codex":0.00027890256,"about_ca_topic_score_gemma":0.000677416,"teacher_disagreement_score":0.0027644536,"about_ca_system_score_codex":0.0002727375,"about_ca_system_score_gemma":0.0003154372,"threshold_uncertainty_score":0.009248078},"labels":[],"label_agreement":null},{"id":"W2177356077","doi":"10.1016/s0960-894x(03)00794-7","title":"Structure–activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Prostanoid; Chemistry; Moiety; Receptor; Stereochemistry; Chemical synthesis; Binding affinities; Affinities; Structure–activity relationship; Carboxylic acid; Biochemistry; In vitro","score_opus":0.01849688948545002,"score_gpt":0.24422322548208478,"score_spread":0.22572633599663475,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2177356077","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9930754,0.0043072207,0.00045303834,0.00009114552,0.00003666534,0.000039960116,0.00022644218,0.00002223859,0.0017478232],"genre_scores_gemma":[0.9934128,0.0038866384,0.00037868935,0.000085791115,0.000036578833,0.00003127089,0.0004945868,0.0000066216357,0.0016670931],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999026,0.000027784457,0.000009553076,0.000008561689,0.000015722866,0.00003577458],"domain_scores_gemma":[0.9998752,0.000049314305,0.000023974902,0.000011143199,0.000014692187,0.00002576934],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000240323,0.00027369714,0.00026914585,0.00023453173,0.00014291686,0.0001803063,0.00028961225,0.00023791796,0.0025155162],"category_scores_gemma":[0.00031385783,0.00014905492,0.00031664362,0.00022929214,0.00016795435,0.00019950455,0.00012601232,0.0004674813,0.00042297656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0051165866,0.00045129997,0.00035713127,0.00013085917,0.00006441486,0.0005008511,0.00006405307,0.0009527452,0.9808832,0.0003003051,0.0002984396,0.010880168],"study_design_scores_gemma":[0.001197994,0.024112329,0.004920688,0.000023330429,0.00025829196,0.00103506,0.000063219406,0.0023975288,0.9607743,0.0001455987,0.0050434284,0.00002817694],"about_ca_topic_score_codex":0.00093448436,"about_ca_topic_score_gemma":0.0011166336,"teacher_disagreement_score":0.0025155162,"about_ca_system_score_codex":0.00015296716,"about_ca_system_score_gemma":0.00016485939,"threshold_uncertainty_score":0.008415282},"labels":[],"label_agreement":null},{"id":"W2177490936","doi":"10.1016/j.bmcl.2006.08.130","title":"Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Antifungal; Borane; Bacteria; Antibacterial activity; Minimum inhibitory concentration; Pharmacology; Combinatorial chemistry; Stereochemistry; In vitro; Organic chemistry; Microbiology; Biochemistry","score_opus":0.007399834479937383,"score_gpt":0.20731063201380812,"score_spread":0.19991079753387073,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2177490936","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.961815,0.015022268,0.013418825,0.00069775106,0.0001538803,0.00027218214,0.000979601,0.00020763751,0.0074329176],"genre_scores_gemma":[0.96375275,0.0063449517,0.022525521,0.00031809736,0.000052977965,0.00009888595,0.0016718059,0.000022773545,0.005212216],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999454,0.0000103041975,0.0000051796956,0.000010131143,0.000012377709,0.000016595239],"domain_scores_gemma":[0.9999515,0.0000068321556,0.000008976469,0.0000035408063,0.0000101211035,0.000019065084],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017333362,0.00038244537,0.00035116883,0.00031381205,0.00019831519,0.00034963252,0.00034515813,0.0005522662,0.0020337957],"category_scores_gemma":[0.00014449032,0.00014959328,0.00027585975,0.00015243847,0.00015221798,0.0003111339,0.00020324801,0.00046626703,0.0004767878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005298157,0.00008834249,0.00019754376,0.00013841587,0.000008814232,0.00012522719,0.000009135994,0.000199714,0.98473144,0.00022542958,0.00015055622,0.0135956295],"study_design_scores_gemma":[0.0002963772,0.0025714114,0.0022684338,0.000033604585,0.000079129735,0.0012327777,0.000026990301,0.0017358261,0.97944885,0.00021467231,0.012068124,0.000023881863],"about_ca_topic_score_codex":0.00045956275,"about_ca_topic_score_gemma":0.0009858796,"teacher_disagreement_score":0.0020337957,"about_ca_system_score_codex":0.00029268724,"about_ca_system_score_gemma":0.00037833175,"threshold_uncertainty_score":0.006803751},"labels":[],"label_agreement":null},{"id":"W2177956173","doi":"10.1016/s0960-894x(02)00644-3","title":"Synthesis and structure–activity relationship of novel aminotetralin derivatives with high μ selective opioid affinity","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre for Research in Astrophysics of Québec; Armand Frappier Museum","funders":"","keywords":"Chemistry; Stereochemistry; Opioid; Aziridine; Selectivity; Structure–activity relationship; Opioid receptor; Stereoselectivity; Receptor; Combinatorial chemistry; Pharmacology; Ring (chemistry); In vitro; Biochemistry; Catalysis; Organic chemistry","score_opus":0.02126594536566471,"score_gpt":0.21192453824345386,"score_spread":0.19065859287778916,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2177956173","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9837013,0.004000748,0.0046442985,0.00021265926,0.00008143682,0.00019781344,0.0004815459,0.00014140218,0.0065388572],"genre_scores_gemma":[0.9904755,0.0021707201,0.0033038978,0.000079871905,0.000019978319,0.00005774031,0.00044023135,0.000023235405,0.0034288724],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990153,0.000019291945,0.00001486748,0.000015907002,0.000020306132,0.000028063994],"domain_scores_gemma":[0.9998952,0.000019102266,0.000033256696,0.0000107579135,0.000013739834,0.000027899967],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018229776,0.00030033677,0.00043247087,0.00019461986,0.00019901569,0.0002884238,0.00052916567,0.00028143855,0.0018954924],"category_scores_gemma":[0.000199998,0.00020191965,0.00020964828,0.00021929103,0.00018159377,0.00026594743,0.00017255658,0.0005457066,0.0005141243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005283426,0.00016087481,0.0001511341,0.00014233403,0.00002596363,0.00036089498,0.00007226978,0.00068535353,0.98721576,0.0006293046,0.00020812912,0.009819714],"study_design_scores_gemma":[0.00024895914,0.0025920859,0.0012266013,0.000010313973,0.00007524827,0.0010495005,0.00002985691,0.0010811823,0.9869876,0.0000935919,0.006577824,0.000027198668],"about_ca_topic_score_codex":0.0006446224,"about_ca_topic_score_gemma":0.0013770367,"teacher_disagreement_score":0.0018954924,"about_ca_system_score_codex":0.00035932157,"about_ca_system_score_gemma":0.00025947051,"threshold_uncertainty_score":0.00634104},"labels":[],"label_agreement":null},{"id":"W2178343817","doi":"10.1016/s0960-894x(02)00765-5","title":"Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"National Research Council Canada; NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Proteases; Cysteine; Cathepsin; Stereochemistry; Amino acid; Cathepsin L; Enzyme inhibitor; Cysteine Proteinase Inhibitors; Enzyme; Biochemistry","score_opus":0.014248393686850354,"score_gpt":0.20607213497618074,"score_spread":0.19182374128933039,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2178343817","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9593388,0.008495424,0.016168937,0.00045305447,0.00040069045,0.00048458722,0.00068494346,0.0003733576,0.013600115],"genre_scores_gemma":[0.97127366,0.0048093884,0.015222774,0.00014489872,0.000056212994,0.00020693723,0.00069854566,0.00005198961,0.007535622],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984956,0.000028399123,0.000014785548,0.000020561518,0.000033784734,0.00005291501],"domain_scores_gemma":[0.9999291,0.0000065891286,0.000015220849,0.0000060013867,0.000013201975,0.000029813367],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019692724,0.00038349937,0.0006629583,0.00028140235,0.00019315735,0.00038531574,0.0007246255,0.00036905007,0.0018731027],"category_scores_gemma":[0.00018023515,0.00028164577,0.00023122718,0.00028344957,0.00019882507,0.00021577571,0.00018898891,0.0006361096,0.00076759554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006046348,0.00020640707,0.00015057449,0.00025991246,0.000027581505,0.0003397079,0.000081675884,0.0022074436,0.97718394,0.0021191174,0.00042197434,0.016397148],"study_design_scores_gemma":[0.0002825492,0.0016063389,0.0007171209,0.000020021747,0.00004979353,0.00035394315,0.000023550112,0.0025754815,0.9809817,0.00023524647,0.013122427,0.00003182783],"about_ca_topic_score_codex":0.00053858745,"about_ca_topic_score_gemma":0.0009669689,"teacher_disagreement_score":0.0018731027,"about_ca_system_score_codex":0.00046711962,"about_ca_system_score_gemma":0.00041202444,"threshold_uncertainty_score":0.0062661767},"labels":[],"label_agreement":null},{"id":"W2178422273","doi":"10.1016/s0960-894x(02)00732-1","title":"Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Abbott Laboratories","keywords":"Chemistry; Neuraminidase inhibitor; Neuraminidase; Stereochemistry; Inhibitory postsynaptic potential; Structure–activity relationship; Enzyme inhibitor; Chemical synthesis; Amino acid; Biochemistry; In vitro; Enzyme; Neuroscience; Coronavirus disease 2019 (COVID-19)","score_opus":0.04355357369555066,"score_gpt":0.21217865984707776,"score_spread":0.1686250861515271,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2178422273","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.984218,0.002255237,0.005034413,0.0002631925,0.0000772996,0.00016589783,0.00024419028,0.00011193234,0.0076298667],"genre_scores_gemma":[0.98896736,0.0019574875,0.0048105395,0.00015001945,0.000018031758,0.000058189187,0.000375619,0.00002442453,0.0036383856],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999012,0.000013461138,0.000009474815,0.000013306163,0.000018987826,0.000043717027],"domain_scores_gemma":[0.99994123,0.000006459525,0.000015135168,0.000006633856,0.000009092344,0.000021513259],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031401,0.00044238503,0.00036507891,0.0002250798,0.00027708279,0.00043586091,0.0005172005,0.00033529225,0.0013153207],"category_scores_gemma":[0.00014709111,0.00024174602,0.00027517442,0.00018001444,0.00032965516,0.00037739624,0.00025759617,0.0006626172,0.00052719645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008037608,0.00022122728,0.00014945722,0.00015019135,0.000019871946,0.0004967835,0.00006555882,0.0019412773,0.97696733,0.002629143,0.00030476597,0.016250659],"study_design_scores_gemma":[0.00025537983,0.0020500934,0.00039644484,0.000012756357,0.00004116024,0.0005255398,0.00003668633,0.001175238,0.9849716,0.0002472362,0.010260668,0.000027113772],"about_ca_topic_score_codex":0.00076200697,"about_ca_topic_score_gemma":0.00133984,"teacher_disagreement_score":0.0013153207,"about_ca_system_score_codex":0.00048683837,"about_ca_system_score_gemma":0.00045380456,"threshold_uncertainty_score":0.0044001937},"labels":[],"label_agreement":null},{"id":"W2178423748","doi":"10.1016/j.bmcl.2008.03.057","title":"Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; In vivo; Isopropyl; Potency; Tyrosine kinase; Stereochemistry; Chemical synthesis; Pharmacokinetics; Structure–activity relationship; In vitro; Selectivity; Receptor tyrosine kinase; Kinase; Tyrosine-kinase inhibitor; Enzyme inhibitor; Pharmacology; Receptor; Biochemistry; Medicinal chemistry; Cancer; Internal medicine","score_opus":0.03409842707840115,"score_gpt":0.30304231239514745,"score_spread":0.2689438853167463,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2178423748","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9821739,0.0050504142,0.004749466,0.00083718967,0.00018372673,0.0005431791,0.000979101,0.00021461875,0.00526841],"genre_scores_gemma":[0.9889014,0.0027760658,0.0024705492,0.0001862015,0.00010988676,0.00029775893,0.0013533592,0.00002438243,0.003880443],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997695,0.00005633907,0.000012470859,0.00003345941,0.000037890044,0.000090344365],"domain_scores_gemma":[0.9998393,0.000028651826,0.00003550707,0.00001871193,0.000013246479,0.000064583095],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074274844,0.0008275139,0.000668985,0.0003929304,0.00019464659,0.000446625,0.00052616076,0.00050395844,0.0013809261],"category_scores_gemma":[0.0003840244,0.00040469976,0.0004075774,0.00021440924,0.00039336065,0.0005252223,0.00014360507,0.0012081503,0.0006044008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0047471714,0.005467732,0.00075793517,0.00026132632,0.00012929758,0.0003686983,0.00014689054,0.0022458911,0.95669794,0.0015672239,0.0016604799,0.025949368],"study_design_scores_gemma":[0.012392182,0.09195483,0.008845203,0.000043323904,0.00047763932,0.0015449243,0.00007813191,0.006454406,0.86426777,0.00056104804,0.013333858,0.000046657275],"about_ca_topic_score_codex":0.00086607796,"about_ca_topic_score_gemma":0.0021609159,"teacher_disagreement_score":0.0013809261,"about_ca_system_score_codex":0.00049082044,"about_ca_system_score_gemma":0.0008613967,"threshold_uncertainty_score":0.004619658},"labels":[],"label_agreement":null},{"id":"W2178610289","doi":"10.1016/j.bmcl.2003.10.032","title":"Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Antibacterial activity; Bacillus subtilis; Antibacterial agent; Stereochemistry; Structure–activity relationship; Chemical synthesis; Enzyme inhibitor; Enterococcus faecalis; Enzyme; Biochemistry; Bacteria; In vitro; Antibiotics; Escherichia coli; Biology","score_opus":0.013699706373007773,"score_gpt":0.2229802094730684,"score_spread":0.20928050310006063,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2178610289","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9248423,0.027472982,0.012180634,0.0011656544,0.0005376741,0.00019100354,0.0006328357,0.0012436325,0.031733256],"genre_scores_gemma":[0.9704963,0.008595971,0.003641921,0.00023925588,0.00013268625,0.00009293007,0.0004107012,0.00002819353,0.016362092],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999374,0.000011768343,0.0000037095842,0.000009685971,0.000012281815,0.00002513481],"domain_scores_gemma":[0.9999633,0.000006878288,0.000009927184,0.0000024108592,0.0000042005972,0.000013326217],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015381431,0.0004497667,0.0003252327,0.00024112724,0.00017782616,0.00033840843,0.00035411687,0.0002638353,0.0024228457],"category_scores_gemma":[0.00009148318,0.00018246958,0.00014286877,0.00012660888,0.00022243588,0.00028159557,0.00019836362,0.0005085449,0.00065862807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013825882,0.0002307872,0.00035335793,0.00038462316,0.000029384539,0.0007084457,0.000121331555,0.0017861454,0.9414126,0.003797072,0.0023163515,0.047477204],"study_design_scores_gemma":[0.00079955225,0.00477373,0.0047390205,0.00003653978,0.00009195845,0.001580081,0.00005570142,0.005861424,0.9192463,0.0007424235,0.062015794,0.000057523528],"about_ca_topic_score_codex":0.00033973716,"about_ca_topic_score_gemma":0.00076388934,"teacher_disagreement_score":0.0024228457,"about_ca_system_score_codex":0.00032981738,"about_ca_system_score_gemma":0.00016522418,"threshold_uncertainty_score":0.008105218},"labels":[],"label_agreement":null},{"id":"W2178641604","doi":"10.1016/j.bmcl.2005.06.072","title":"Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Sulfonamide; Chemistry; Stereochemistry; Combinatorial chemistry; Chemical synthesis; Enzyme inhibitor; Enzyme; In vitro; Organic chemistry; Biochemistry","score_opus":0.005748033347098491,"score_gpt":0.20920025474401657,"score_spread":0.20345222139691807,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2178641604","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9134946,0.05055348,0.014694954,0.0010190762,0.0004482935,0.0005177292,0.0013940395,0.00039885985,0.01747891],"genre_scores_gemma":[0.9463171,0.038227823,0.004211542,0.0006727439,0.00021677776,0.00023053217,0.0021486918,0.00002203454,0.007952791],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994814,0.000011743826,0.000005370853,0.000004294949,0.0000128008705,0.000017680792],"domain_scores_gemma":[0.9999583,0.0000091270595,0.000009881381,0.0000040357345,0.0000067592214,0.0000119202205],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027954255,0.0005494682,0.00036033368,0.00022287086,0.00010982828,0.00015329014,0.00030663895,0.00019629754,0.0012308037],"category_scores_gemma":[0.0001632991,0.00012765799,0.00022045098,0.00016620004,0.00015495194,0.00022503603,0.00015989729,0.0005101373,0.00047172196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013566567,0.0004243055,0.0003560673,0.00049208896,0.00006436441,0.000541735,0.00013198762,0.004530002,0.90438145,0.0012803781,0.0036911075,0.08274989],"study_design_scores_gemma":[0.002010189,0.019126216,0.010467334,0.00016224071,0.00029665788,0.0032094512,0.00012028212,0.0074236686,0.8479444,0.00085190334,0.10830115,0.00008639604],"about_ca_topic_score_codex":0.00047876066,"about_ca_topic_score_gemma":0.0009988662,"teacher_disagreement_score":0.0012308037,"about_ca_system_score_codex":0.0002090714,"about_ca_system_score_gemma":0.00019850873,"threshold_uncertainty_score":0.0041174293},"labels":[],"label_agreement":null},{"id":"W2179100710","doi":"10.1016/j.bmcl.2005.02.006","title":"Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Amyloid precursor protein secretase; Enzyme; Gamma secretase; Amyloid precursor protein; Enzyme inhibitor; Alzheimer's disease; Biochemistry; Neuroscience; Stereochemistry; Disease; Pharmacology; Internal medicine; Psychology","score_opus":0.022871833699999018,"score_gpt":0.27322240961524097,"score_spread":0.25035057591524196,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2179100710","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95311606,0.0053813057,0.03467188,0.0002906968,0.00007625966,0.00026002637,0.0004740698,0.0002673852,0.005462269],"genre_scores_gemma":[0.9657854,0.00463336,0.026655495,0.000063096464,0.000015636486,0.00009720501,0.00041542144,0.00004057792,0.0022938391],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999366,0.000013993246,0.000005842762,0.000010979927,0.00001946321,0.000013155534],"domain_scores_gemma":[0.9999423,0.000013906892,0.000020534539,0.0000046559553,0.000009414496,0.000009173057],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020912361,0.00042079136,0.00039594056,0.00012574477,0.00015766956,0.00029720433,0.0004681765,0.00019981676,0.0015347551],"category_scores_gemma":[0.00023676005,0.00024344515,0.0002601361,0.00014498219,0.00012126301,0.00028211364,0.00012604309,0.0005557731,0.00029141174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012905484,0.00026734723,0.00042925272,0.0006625616,0.000058272988,0.0005157319,0.00009876174,0.067487925,0.8923096,0.004154031,0.00048573996,0.03224032],"study_design_scores_gemma":[0.0004949594,0.00286308,0.0005825585,0.00004505443,0.00015646017,0.00036743347,0.000052736894,0.11372709,0.8691745,0.00046857973,0.012026631,0.000041013132],"about_ca_topic_score_codex":0.00080480415,"about_ca_topic_score_gemma":0.0015267412,"teacher_disagreement_score":0.0015347551,"about_ca_system_score_codex":0.00036697087,"about_ca_system_score_gemma":0.00029043955,"threshold_uncertainty_score":0.0051342845},"labels":[],"label_agreement":null},{"id":"W2179204391","doi":"10.1016/j.bmcl.2004.09.003","title":"1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Reaction Mechanisms","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Amine gas treating; 5-HT6 receptor; Tertiary amine; Receptor; Stereochemistry; Affinities; Aromatic amine; 5-HT receptor; Serotonin; Biochemistry; Organic chemistry","score_opus":0.01004796482071824,"score_gpt":0.2223739430574032,"score_spread":0.21232597823668498,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2179204391","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93830013,0.027872894,0.012799119,0.00042440288,0.00023654773,0.000122049634,0.0005690258,0.00043988414,0.019235913],"genre_scores_gemma":[0.9790163,0.0074074618,0.004332149,0.00014013624,0.000057736397,0.00005144794,0.0003227506,0.00002050705,0.008651561],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993515,0.000017083556,0.0000030344952,0.000007979794,0.000013321776,0.00002345363],"domain_scores_gemma":[0.9999691,0.0000052759597,0.000008317698,0.0000026889668,0.000004676515,0.00000989722],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017290674,0.00022405549,0.00023483559,0.00016319544,0.00014740055,0.0002095214,0.0004757112,0.00025135544,0.0016809282],"category_scores_gemma":[0.00008850491,0.00010529946,0.00014428158,0.00012253791,0.000119686316,0.00020607577,0.00016874848,0.00034900598,0.00074025587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007328181,0.00015227136,0.00036805577,0.00023550873,0.000018072818,0.000493708,0.000102112164,0.0011545593,0.9613515,0.003002347,0.0010526562,0.0313364],"study_design_scores_gemma":[0.0002908163,0.0037640638,0.003911013,0.000041742034,0.00007701677,0.0016231525,0.00008160186,0.0059128627,0.9292762,0.00045620595,0.05451909,0.000046297642],"about_ca_topic_score_codex":0.00044867024,"about_ca_topic_score_gemma":0.0015621269,"teacher_disagreement_score":0.0016809282,"about_ca_system_score_codex":0.00028003522,"about_ca_system_score_gemma":0.00013545774,"threshold_uncertainty_score":0.005623281},"labels":[],"label_agreement":null},{"id":"W2179212814","doi":"10.1016/s0960-894x(02)00766-7","title":"6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"National Research Council Canada; NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Sulfone; Cathepsin; Stereochemistry; Proteases; Cathepsin B; Lactam; Enzyme inhibitor; Chemical synthesis; Cysteine; In vitro; Biochemistry; Enzyme; Organic chemistry","score_opus":0.009183474942674966,"score_gpt":0.19249198630694977,"score_spread":0.1833085113642748,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2179212814","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9570728,0.017424304,0.011154718,0.0005892666,0.00029114072,0.00017650951,0.0010374233,0.00038029332,0.011873529],"genre_scores_gemma":[0.9830914,0.0064036986,0.0043822248,0.00011108205,0.000045525463,0.00005021761,0.00051730743,0.000032472377,0.0053661247],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998808,0.000023783334,0.000014708517,0.000014924108,0.000022293463,0.000043573535],"domain_scores_gemma":[0.9999161,0.0000116424535,0.000024357441,0.000013297228,0.000008930751,0.000025682315],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021373566,0.0005096605,0.0003409469,0.00026437166,0.00014052646,0.0002780641,0.000559146,0.00043228603,0.0017103562],"category_scores_gemma":[0.00023109383,0.00020698753,0.00034173555,0.00025422158,0.00024503705,0.00040711238,0.00021795489,0.00078474334,0.00070150825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012120036,0.00022727181,0.0001649906,0.00023964774,0.000046782166,0.0010619097,0.00007179846,0.0011644347,0.97197634,0.0013334709,0.0006230197,0.021878226],"study_design_scores_gemma":[0.00011824428,0.001286759,0.0005653151,0.000007042964,0.000031563563,0.0006335305,0.000011507433,0.0004843085,0.99072987,0.00009287413,0.0060274573,0.0000115881785],"about_ca_topic_score_codex":0.00036657526,"about_ca_topic_score_gemma":0.00038002018,"teacher_disagreement_score":0.0017103562,"about_ca_system_score_codex":0.0002912762,"about_ca_system_score_gemma":0.0002470022,"threshold_uncertainty_score":0.0057216883},"labels":[],"label_agreement":null},{"id":"W2179461628","doi":"10.1016/j.bmcl.2004.01.028","title":"Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA–FtsZ interaction","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":60,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"Zhejiang Pharmaceutical Association","keywords":"FtsZ; Chemistry; Stereochemistry; Biochemistry; Cytoskeleton; Cell","score_opus":0.03170809101371981,"score_gpt":0.2379478597943535,"score_spread":0.20623976878063371,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2179461628","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9205287,0.015025497,0.046956494,0.0009505979,0.00036423793,0.001955447,0.0016452223,0.00069843803,0.011875394],"genre_scores_gemma":[0.96859455,0.0061604697,0.01701296,0.00021243589,0.000054076456,0.00037671736,0.0014402954,0.000051117087,0.0060975216],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986684,0.000021924874,0.000010865882,0.000020943238,0.000031572723,0.000047801583],"domain_scores_gemma":[0.9998957,0.00001466877,0.000028639672,0.000007807669,0.00002101112,0.00003221283],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034307392,0.00051138585,0.0005949723,0.00043679567,0.0002992127,0.00046868532,0.0012018861,0.00038736864,0.0022837939],"category_scores_gemma":[0.00027154526,0.00039334546,0.00035171764,0.00021276764,0.000284458,0.00030814088,0.00025524382,0.0009590243,0.0007261446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011955311,0.0006184514,0.00034969958,0.00046365013,0.00009359761,0.00065964495,0.00016942651,0.0066746078,0.9532752,0.0036947809,0.0014015315,0.03140395],"study_design_scores_gemma":[0.0014149343,0.003645619,0.0013798012,0.000050455725,0.0001925051,0.0007725382,0.000045825425,0.011231996,0.9497143,0.00046370423,0.031014407,0.000073977215],"about_ca_topic_score_codex":0.000909156,"about_ca_topic_score_gemma":0.0023285898,"teacher_disagreement_score":0.0022837939,"about_ca_system_score_codex":0.0006174295,"about_ca_system_score_gemma":0.00055906444,"threshold_uncertainty_score":0.007640004},"labels":[],"label_agreement":null},{"id":"W2179735562","doi":"10.1016/j.bmcl.2004.07.071","title":"Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure–activity relationships of (N-methyl-piperazinyl)-containing derivatives","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Efflux; Chemistry; Fluconazole; Candida albicans; In vitro; Quinazolinone; Candida glabrata; Structure–activity relationship; Stereochemistry; Pharmacology; Biochemistry; Microbiology; Antifungal; Biology","score_opus":0.029536238880602524,"score_gpt":0.2479592748288595,"score_spread":0.21842303594825696,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2179735562","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9720613,0.019139294,0.002931293,0.00025955023,0.000089843175,0.00019016066,0.0016206366,0.00014015632,0.0035677406],"genre_scores_gemma":[0.9814433,0.01043125,0.0020722365,0.00012122788,0.00004877218,0.00009803112,0.0020612266,0.000018919642,0.0037049432],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998809,0.000032214775,0.000013027583,0.00001611087,0.000025801039,0.00003200178],"domain_scores_gemma":[0.9998871,0.000032326694,0.00002735025,0.000013312893,0.000017358934,0.000022501456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025301834,0.00047393452,0.0004397685,0.00030381687,0.00015217777,0.00017563367,0.00041039684,0.00022433166,0.0031731124],"category_scores_gemma":[0.00031361615,0.00021645859,0.00031586725,0.00026437873,0.00014734856,0.00025373994,0.00014604321,0.00050244253,0.0005349052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002382119,0.000619382,0.00050067017,0.00037859284,0.000062323816,0.0002211207,0.00007527544,0.0011589631,0.9694816,0.00017008909,0.0008028485,0.024147023],"study_design_scores_gemma":[0.0012868464,0.021404652,0.0128576625,0.000048631577,0.00025578585,0.0012507275,0.000040220297,0.0012873177,0.9508481,0.000070065806,0.010601721,0.00004827135],"about_ca_topic_score_codex":0.0010327563,"about_ca_topic_score_gemma":0.0027226575,"teacher_disagreement_score":0.0031731124,"about_ca_system_score_codex":0.00022089639,"about_ca_system_score_gemma":0.00022031482,"threshold_uncertainty_score":0.01061511},"labels":[],"label_agreement":null},{"id":"W2179832516","doi":"10.1016/j.bmcl.2005.08.024","title":"A synthesis of 3-deoxydihydrolycoricidine: Refinement of a structurally minimum pancratistatin pharmacophore","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":66,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pharmacophore; Chemistry; Stereochemistry; Triol; Combinatorial chemistry; Chemical synthesis; Ring (chemistry); In vitro; Biochemistry; Organic chemistry","score_opus":0.00681466408128051,"score_gpt":0.22012163246870708,"score_spread":0.21330696838742658,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2179832516","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.940454,0.0021819035,0.03811174,0.00049021875,0.00025885785,0.00070203794,0.0019677822,0.00053822546,0.015295236],"genre_scores_gemma":[0.96356255,0.0013548351,0.029599084,0.00015697331,0.000024968595,0.00010525683,0.0013063832,0.00007482242,0.0038151485],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998597,0.000021612552,0.000014548805,0.000035765846,0.000035858746,0.00003249305],"domain_scores_gemma":[0.99988854,0.000013502882,0.000017773953,0.00002345023,0.000021527641,0.000035177527],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017647317,0.00028069815,0.00040636485,0.00015562685,0.00021215038,0.00024572838,0.0005989125,0.00041559062,0.0014288975],"category_scores_gemma":[0.00030831338,0.00018176422,0.00020187136,0.00021752472,0.00019022622,0.00020625602,0.00022669144,0.0006176346,0.00073389104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031684744,0.00008358863,0.00013086345,0.000090533205,0.0000101438945,0.0003064607,0.000048980055,0.0016009707,0.9832201,0.0008327597,0.00029037648,0.013068351],"study_design_scores_gemma":[0.00017520922,0.0013540178,0.0006212532,0.000010375375,0.000026903357,0.00050392374,0.000019742396,0.0017848363,0.9810013,0.00020211453,0.014278711,0.000021724345],"about_ca_topic_score_codex":0.0013582206,"about_ca_topic_score_gemma":0.0020202363,"teacher_disagreement_score":0.0014288975,"about_ca_system_score_codex":0.00045176107,"about_ca_system_score_gemma":0.00078942016,"threshold_uncertainty_score":0.0047801733},"labels":[],"label_agreement":null},{"id":"W2180364919","doi":"10.1016/s0960-894x(03)00677-2","title":"1,2,5,6-Tetra-O-benzyl-d-mannitol derivatives as novel HIV protease inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SNC-Lavalin (Canada)","funders":"","keywords":"Chemistry; Protease; Chemical synthesis; HIV-1 protease; Enzyme inhibitor; Tetra; Human immunodeficiency virus (HIV); Stereochemistry; Enzyme; Combinatorial chemistry; Biochemistry; In vitro; Medicinal chemistry; Virology","score_opus":0.011990879926338599,"score_gpt":0.240217030064376,"score_spread":0.2282261501380374,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2180364919","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9533665,0.022743652,0.0060740598,0.0005993576,0.00028245777,0.0001254347,0.00047584288,0.00038220087,0.01595055],"genre_scores_gemma":[0.98360014,0.008455155,0.0030399568,0.00013034062,0.00004536136,0.000047077036,0.00028841067,0.00002365979,0.00436993],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993193,0.000017622446,0.000003989768,0.0000073415963,0.000011386839,0.00002771168],"domain_scores_gemma":[0.9999709,0.0000039562924,0.000007080228,0.0000027726942,0.0000035583903,0.000011719904],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104947714,0.00032457293,0.00032607344,0.00021332786,0.00016649236,0.0003474233,0.0003846555,0.00030295,0.0010830732],"category_scores_gemma":[0.00009609095,0.00013269112,0.00014169926,0.0001847636,0.00019476669,0.00024608147,0.00017988215,0.00054949464,0.00044273704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011620214,0.0002882482,0.00020863423,0.00023570418,0.000023843926,0.00052454486,0.00008362007,0.0025702482,0.96010894,0.0029258637,0.0009874756,0.03088095],"study_design_scores_gemma":[0.0002590375,0.002807703,0.0013875412,0.000027878094,0.000047484868,0.00064254744,0.00004349684,0.004068832,0.9654543,0.00030877712,0.024921026,0.000031384265],"about_ca_topic_score_codex":0.00047121977,"about_ca_topic_score_gemma":0.00079789996,"teacher_disagreement_score":0.0010830732,"about_ca_system_score_codex":0.00037319015,"about_ca_system_score_gemma":0.00015548251,"threshold_uncertainty_score":0.0036232471},"labels":[],"label_agreement":null},{"id":"W2180740327","doi":"10.1016/j.bmcl.2003.12.032","title":"Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Chemistry; Benzimidazole; Polymerase; RNA polymerase; Potency; Hepatitis C virus; Enzyme; RNA-dependent RNA polymerase; Biochemistry; Nucleotidyltransferase; Virology; Nucleoside; Structure–activity relationship; Stereochemistry; RNA; Virus; Hepacivirus; In vitro; Biology","score_opus":0.005753133087768912,"score_gpt":0.2231402569191561,"score_spread":0.21738712383138717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2180740327","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93308765,0.03293481,0.017653523,0.00057324383,0.0002077209,0.00041285952,0.00061012956,0.00028757183,0.014232608],"genre_scores_gemma":[0.9688447,0.013883154,0.009412859,0.00031513424,0.00007378317,0.00011541381,0.00086865964,0.000034885354,0.006451493],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999001,0.000019714073,0.0000062803347,0.000011860586,0.000032841235,0.000029051496],"domain_scores_gemma":[0.9999169,0.000018684848,0.000016717393,0.0000073759156,0.00001650219,0.0000238522],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032083373,0.00054902426,0.00035895692,0.00015883888,0.00012549142,0.00024310163,0.00045691722,0.00030798875,0.0013828521],"category_scores_gemma":[0.00026372893,0.00018497372,0.0002033308,0.00009632435,0.00019104782,0.00019551003,0.00017985643,0.0005551912,0.00043712207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005687238,0.0002154574,0.00029868257,0.0002488364,0.000019677815,0.00033659604,0.00005955574,0.0009148713,0.96228313,0.00092160096,0.00058046094,0.03355228],"study_design_scores_gemma":[0.0007656951,0.0066344813,0.003796955,0.00006226888,0.000077626624,0.0014355949,0.000035918307,0.0029831033,0.95948935,0.00030547107,0.024370017,0.000043548618],"about_ca_topic_score_codex":0.00065713265,"about_ca_topic_score_gemma":0.0028824608,"teacher_disagreement_score":0.0013828521,"about_ca_system_score_codex":0.0003696504,"about_ca_system_score_gemma":0.0002669725,"threshold_uncertainty_score":0.0046260953},"labels":[],"label_agreement":null},{"id":"W2180908646","doi":"10.1016/j.bmcl.2004.04.093","title":"Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N′-arylthiourea inhibitors of CMV","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Thiourea; Cytomegalovirus; Human cytomegalovirus; IC50; Virus; Enzyme inhibitor; Betaherpesvirinae; Virology; In vitro; Herpesviridae; Stereochemistry; Biochemistry; Viral disease; Organic chemistry","score_opus":0.02193898272621519,"score_gpt":0.27636636255550845,"score_spread":0.25442737982929325,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2180908646","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.677163,0.26033592,0.015136409,0.0009437403,0.0016027564,0.0007988915,0.0010750525,0.00063793425,0.042306297],"genre_scores_gemma":[0.79456514,0.16968471,0.003911025,0.0007110666,0.0007367482,0.00041403805,0.0014246051,0.000085763066,0.028466932],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999168,0.000015124006,0.0000066184903,0.0000074141317,0.000016446744,0.000037497262],"domain_scores_gemma":[0.99995494,0.000014290458,0.000010212385,0.0000047237463,0.000006151674,0.000009569881],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026400315,0.0007878908,0.0004252051,0.0009017251,0.00023146892,0.0002138278,0.00054718606,0.00031732873,0.0023063878],"category_scores_gemma":[0.00017659976,0.0002699384,0.0005963791,0.00036792227,0.00017689064,0.00031128997,0.00022753551,0.0004996074,0.00062631565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014974864,0.0010623048,0.0005381489,0.0010496743,0.00016891366,0.000726438,0.00019652153,0.0035343058,0.80347514,0.0015084356,0.0061064097,0.18013622],"study_design_scores_gemma":[0.00107105,0.011636519,0.00963954,0.00014780593,0.0003812014,0.002459526,0.000056925976,0.0028179195,0.8807113,0.00045728986,0.09054852,0.00007227446],"about_ca_topic_score_codex":0.0014448217,"about_ca_topic_score_gemma":0.0029412978,"teacher_disagreement_score":0.0023063878,"about_ca_system_score_codex":0.00039129314,"about_ca_system_score_gemma":0.0002623261,"threshold_uncertainty_score":0.007715702},"labels":[],"label_agreement":null},{"id":"W2181120188","doi":"10.1016/j.bmcl.2004.12.005","title":"2,3-Diarylthiophenes as selective EP1 receptor antagonists","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Receptor; Pharmacokinetics; Chemical synthesis; Pharmacology; Stereochemistry; Selectivity; Structure–activity relationship; Biochemistry; In vitro; Biology","score_opus":0.005011861217368217,"score_gpt":0.23433215703420293,"score_spread":0.22932029581683472,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2181120188","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9197464,0.032981962,0.015957791,0.0007495354,0.00055090437,0.00022077918,0.000794821,0.000501674,0.028495999],"genre_scores_gemma":[0.9638741,0.015358101,0.0038353936,0.00040031478,0.00009177433,0.00012911743,0.00046412356,0.000044818484,0.015802255],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999081,0.000020690859,0.0000044665003,0.000012403078,0.000014876754,0.000039541374],"domain_scores_gemma":[0.9999658,0.0000090495305,0.000007681467,0.000004883537,0.000003789002,0.000008873015],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019483877,0.0003498993,0.00027719245,0.000167352,0.00015115186,0.00024776193,0.00043792638,0.0002983254,0.0030937602],"category_scores_gemma":[0.0001314118,0.00018094096,0.00013759072,0.00018646118,0.00014928308,0.00028738953,0.00021933138,0.00057203334,0.00073777826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00095152017,0.0001156762,0.000111039095,0.00032214017,0.000020753112,0.00037895972,0.00007709041,0.0010419878,0.9634364,0.0024061112,0.0015007313,0.02963757],"study_design_scores_gemma":[0.00037666823,0.002704511,0.0018353396,0.000037617338,0.000056719018,0.0007012789,0.000035588353,0.0027333235,0.9534299,0.00047220773,0.037582297,0.00003460986],"about_ca_topic_score_codex":0.00035420293,"about_ca_topic_score_gemma":0.0008688556,"teacher_disagreement_score":0.0030937602,"about_ca_system_score_codex":0.0002600121,"about_ca_system_score_gemma":0.00016597896,"threshold_uncertainty_score":0.010349631},"labels":[],"label_agreement":null},{"id":"W2185184588","doi":"10.1016/j.bmcl.2015.10.072","title":"Solid-phase synthesis and in vitro biological activity of a Thr4→Ser4 analog of daptomycin","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Waterloo","keywords":"Daptomycin; Chemistry; In vitro; Biological activity; Stereochemistry; Chemical synthesis; Pharmacology; Biochemistry; Bacteria","score_opus":0.021639271169198074,"score_gpt":0.2992799104334448,"score_spread":0.27764063926424676,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2185184588","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9903867,0.00071103225,0.0051183607,0.00008380505,0.000054554726,0.000061877116,0.0007393418,0.00008481864,0.0027594953],"genre_scores_gemma":[0.99311936,0.00042196678,0.0033703493,0.000022636637,0.0000088954175,0.000022396756,0.00075827615,0.00002316653,0.0022530933],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991786,0.000019304627,0.000010254302,0.000013353141,0.000019402783,0.00001981228],"domain_scores_gemma":[0.99993324,0.000018164517,0.000015277657,0.000010655023,0.000009262816,0.000013436021],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011681057,0.0002589725,0.00019496273,0.0001298659,0.0001353316,0.0001785457,0.00024916814,0.00016019824,0.0014235772],"category_scores_gemma":[0.00013032899,0.0001043636,0.00013317939,0.00015384864,0.000114857336,0.00011719594,0.00011292071,0.0003531225,0.0003781738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035259355,0.00007043839,0.00006327499,0.000036117664,0.00000605822,0.000067543704,0.000008154364,0.0007538039,0.9961051,0.00018222441,0.00006303053,0.00229184],"study_design_scores_gemma":[0.000027460608,0.00028993358,0.00013334648,0.0000010689989,0.000004903674,0.000039086717,0.0000037410607,0.0005082968,0.99782145,0.000024016917,0.0011444567,0.0000022396084],"about_ca_topic_score_codex":0.00044919914,"about_ca_topic_score_gemma":0.0004795351,"teacher_disagreement_score":0.0014235772,"about_ca_system_score_codex":0.00028123177,"about_ca_system_score_gemma":0.0002405681,"threshold_uncertainty_score":0.004762292},"labels":[],"label_agreement":null},{"id":"W2194728256","doi":"10.1016/j.bmcl.2015.11.066","title":"Synthesis and evaluation of 18F-labeled 4-nitrobenzyl derivatives for imaging tumor hypoxia with positron emission tomography: Comparison of 2-[18F]fluoroethyl carbonate and 2-[18F]fluoroethyl carbamate","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Positron emission tomography; Carbonate; Hypoxia (environmental); Nuclear medicine; Radiochemistry; Organic chemistry; Oxygen","score_opus":0.018224385002985465,"score_gpt":0.2728660765668905,"score_spread":0.25464169156390504,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2194728256","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9610412,0.0055726264,0.027226768,0.00021990729,0.00007161343,0.00064876454,0.0007486726,0.00014620776,0.0043242625],"genre_scores_gemma":[0.96294594,0.0035162864,0.028212165,0.00008656133,0.000033591186,0.00021808344,0.0014253046,0.000099708945,0.0034623311],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997396,0.00008441739,0.000019859479,0.000041672833,0.000050266313,0.00006407234],"domain_scores_gemma":[0.9996669,0.000058436355,0.00006943957,0.000043155178,0.000084082574,0.0000778819],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006556164,0.0005118077,0.0005677795,0.00036445906,0.000269122,0.00029914995,0.00077388325,0.00077436055,0.0010609997],"category_scores_gemma":[0.0006037612,0.0003657858,0.0002933524,0.0003584553,0.0002850281,0.00041867033,0.00021777728,0.00042975295,0.00046516187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008639449,0.00017268602,0.0002351878,0.00014735134,0.000028635075,0.00031524475,0.000099597324,0.0008297059,0.98853755,0.00043851274,0.0001178287,0.008213736],"study_design_scores_gemma":[0.00009803322,0.001225427,0.0005461538,0.000006946894,0.000048648493,0.00039042847,0.000016132537,0.00080251537,0.9936274,0.000023501823,0.0032007364,0.000013962041],"about_ca_topic_score_codex":0.0024897286,"about_ca_topic_score_gemma":0.0027049477,"teacher_disagreement_score":0.0024897286,"about_ca_system_score_codex":0.0004684341,"about_ca_system_score_gemma":0.0005314841,"threshold_uncertainty_score":0.0049505234},"labels":[],"label_agreement":null},{"id":"W2205706443","doi":"10.1016/j.bmcl.2015.10.043","title":"Incorporation of cyclic azobenzene into oligodeoxynucleotides for the photo-regulation of DNA hybridization","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphoramidite; Chemistry; Oligonucleotide; Azobenzene; Förster resonance energy transfer; DNA; Fluorescence; Fluorescein; Combinatorial chemistry; Stereochemistry; Photochemistry; Biochemistry; Organic chemistry; Molecule","score_opus":0.01919784763039613,"score_gpt":0.23760278907054005,"score_spread":0.2184049414401439,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2205706443","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97792345,0.0023487993,0.016250383,0.00012768873,0.00008246319,0.000068011665,0.00020066925,0.00018853972,0.0028099332],"genre_scores_gemma":[0.98906785,0.00067470974,0.0077810376,0.0000498331,0.000009244775,0.00003298822,0.00015790296,0.000025837715,0.0022005541],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998448,0.000024970264,0.000011325786,0.000044292836,0.000037979615,0.000036569814],"domain_scores_gemma":[0.9998698,0.00004209815,0.000026872605,0.000017336859,0.000014747656,0.000029109107],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158572,0.00025993254,0.00019369238,0.0001385419,0.00019206225,0.00028549996,0.00028470872,0.00032657958,0.0009095537],"category_scores_gemma":[0.00023015533,0.00019135448,0.00020672126,0.00016215694,0.00025017315,0.00018329106,0.00019133934,0.00043318694,0.00023878882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000034346438,0.0000058167384,0.000018746852,0.000013368301,0.0000016026753,0.000012509622,0.00000703357,0.00004810241,0.9991503,0.00009753311,0.000008189502,0.0006026006],"study_design_scores_gemma":[0.0000027814683,0.000043630895,0.00009618413,9.696134e-7,0.0000027804817,0.000018048762,0.0000014833732,0.0001946645,0.99919397,0.000010278972,0.00043264803,0.0000026258751],"about_ca_topic_score_codex":0.00096721813,"about_ca_topic_score_gemma":0.0023068246,"teacher_disagreement_score":0.00096721813,"about_ca_system_score_codex":0.00038486748,"about_ca_system_score_gemma":0.00031702302,"threshold_uncertainty_score":0.003042817},"labels":[],"label_agreement":null},{"id":"W2218990407","doi":"10.1016/j.bmcl.2015.12.050","title":"Salicylates are interference compounds in TR-FRET assays","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BC Cancer Agency; University of Victoria","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC; Universities Space Research Association; National Cancer Research Institute","keywords":"Chemistry; Förster resonance energy transfer; Context (archaeology); Drug discovery; High-throughput screening; Computational biology; Combinatorial chemistry; Biophysics; Biochemistry; Fluorescence","score_opus":0.0216691796743399,"score_gpt":0.2403927361162143,"score_spread":0.2187235564418744,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2218990407","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.73098105,0.0062404824,0.22357066,0.0013297249,0.0005697277,0.0009522898,0.0029694648,0.004670065,0.02871654],"genre_scores_gemma":[0.8504323,0.0038734295,0.11921326,0.0004971059,0.00009240619,0.001343612,0.004746486,0.00040751192,0.0193939],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9951746,0.0017201789,0.00036154146,0.0008168418,0.0012439596,0.0006827869],"domain_scores_gemma":[0.9992818,0.0002528261,0.000111066285,0.00019332435,0.0000990238,0.00006198737],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016481635,0.0017008869,0.00132722,0.0007507932,0.0009325285,0.0009534336,0.0025142794,0.001970616,0.0036474008],"category_scores_gemma":[0.0010483479,0.0010210288,0.0010487555,0.0011134943,0.00081813586,0.0008108991,0.0011142069,0.0032132524,0.00278904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001940546,0.000067758105,0.00010271046,0.00013664311,0.000027451259,0.00007696862,0.000054080283,0.00017531941,0.99550503,0.0007276819,0.00040784915,0.0025245876],"study_design_scores_gemma":[0.000009347928,0.00006260494,0.00014996948,0.000004938058,0.000008994445,0.00007101894,0.000011762156,0.0005474732,0.9979658,0.000053765914,0.0011083052,0.000005857934],"about_ca_topic_score_codex":0.0007420067,"about_ca_topic_score_gemma":0.001873284,"teacher_disagreement_score":0.0036474008,"about_ca_system_score_codex":0.00097258424,"about_ca_system_score_gemma":0.0004847622,"threshold_uncertainty_score":0.012201726},"labels":[],"label_agreement":null},{"id":"W2225252038","doi":"10.1016/j.bmcl.2016.01.005","title":"1-[3-(2-Hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones: A novel cluster of P-glycoprotein dependent multidrug resistance modulators","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Multiple drug resistance; P-glycoprotein; Chemistry; Cytotoxicity; Stereochemistry; Pharmacology; In vitro; Biochemistry; Medicine; Antibiotics","score_opus":0.007699560830480326,"score_gpt":0.20952273907893584,"score_spread":0.20182317824845553,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2225252038","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9411713,0.015468221,0.022766234,0.0008330131,0.0002845429,0.00022167452,0.0008473255,0.0009837335,0.017423967],"genre_scores_gemma":[0.9709202,0.006763734,0.01200409,0.00019753835,0.0000786596,0.00023783674,0.00066264207,0.00004735841,0.009087912],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992716,0.00001928052,0.0000038313788,0.0000143368425,0.000016930442,0.000018453831],"domain_scores_gemma":[0.99996006,0.000004508438,0.000009832263,0.0000042508686,0.000007669542,0.000013825903],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013111216,0.00029976977,0.00032400992,0.00020368608,0.00020289891,0.00023966194,0.0005052039,0.00023291146,0.0013967254],"category_scores_gemma":[0.000108430424,0.00012260301,0.000113228445,0.0001592605,0.00016111291,0.00022915447,0.00029513292,0.0004568436,0.000680736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00093033834,0.00017698685,0.00023200474,0.00022172084,0.000016550399,0.00030136813,0.00010441736,0.0012196089,0.9553446,0.0035381964,0.002011453,0.035902802],"study_design_scores_gemma":[0.00043188172,0.0046342965,0.004183154,0.000034537214,0.000056115055,0.0010854482,0.00006521813,0.006417831,0.9111867,0.000712578,0.07115052,0.000041602892],"about_ca_topic_score_codex":0.00030735575,"about_ca_topic_score_gemma":0.00047827425,"teacher_disagreement_score":0.0013967254,"about_ca_system_score_codex":0.0003436032,"about_ca_system_score_gemma":0.0002634608,"threshold_uncertainty_score":0.0046724677},"labels":[],"label_agreement":null},{"id":"W2250473564","doi":"10.1016/j.bmcl.2016.01.069","title":"Anti-inflammatory and antioxidant properties of a novel resveratrol–salicylate hybrid analog","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Universidad Nacional Autónoma de México; Consejo Nacional de Ciencia y Tecnología; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Alberta Innovates - Health Solutions","keywords":"Resveratrol; Chemistry; Myeloperoxidase; Antioxidant; Pharmacology; In vivo; Oxidative stress; Anti-inflammatory; Biochemistry; Reactive oxygen species; In vitro; Inflammation; Carrageenan; Immunology","score_opus":0.0147787365751636,"score_gpt":0.21790611584105077,"score_spread":0.20312737926588717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2250473564","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9921381,0.0021713292,0.0015584454,0.00012796237,0.000054506603,0.000041298157,0.00031690332,0.00006963121,0.0035218296],"genre_scores_gemma":[0.996214,0.0006884693,0.0010284897,0.000061561834,0.000009812773,0.000008872935,0.00025286607,0.0000046699106,0.0017311104],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995947,0.000007589676,0.0000039798756,0.000009455788,0.000009411624,0.000010124544],"domain_scores_gemma":[0.9999769,0.0000034389986,0.0000051393476,0.0000028768786,0.000003388925,0.0000083140685],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008100517,0.00019353177,0.00019215015,0.00018020386,0.00011797689,0.000142557,0.00027080995,0.00024151425,0.0025292607],"category_scores_gemma":[0.000056365385,0.00008638556,0.0002065463,0.00011895437,0.000101808895,0.00016935923,0.00012718777,0.0002958437,0.0003658698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00062978803,0.00009464761,0.000080498765,0.0001117197,0.00002363876,0.00010167889,0.00002031833,0.00028038907,0.99365014,0.00015480952,0.00011549769,0.004736826],"study_design_scores_gemma":[0.00019633613,0.00337733,0.002161079,0.000011626558,0.00010154592,0.00030357298,0.000043926193,0.0013375656,0.98543894,0.00007920911,0.0069241375,0.000024853425],"about_ca_topic_score_codex":0.00027241706,"about_ca_topic_score_gemma":0.000650182,"teacher_disagreement_score":0.0025292607,"about_ca_system_score_codex":0.00010054818,"about_ca_system_score_gemma":0.00007629533,"threshold_uncertainty_score":0.008461237},"labels":[],"label_agreement":null},{"id":"W2254805026","doi":"10.1016/j.bmcl.2016.01.080","title":"In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Generalitat de Catalunya; Natural Sciences and Engineering Research Council of Canada; Alzheimer Society","keywords":"In silico; Acetylcholinesterase; Chemistry; Virtual screening; Docking (animal); In vitro; Enzyme; Stereochemistry; Combinatorial chemistry; Chemical synthesis; Structure–activity relationship; Enzyme inhibitor; Biochemistry; Drug discovery; Pharmacology; Biology","score_opus":0.013294420692762253,"score_gpt":0.2733733359962335,"score_spread":0.2600789153034712,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2254805026","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9581243,0.005324661,0.020364111,0.00036920345,0.00012176077,0.0002475477,0.004330301,0.0005600477,0.010558012],"genre_scores_gemma":[0.9810724,0.003540036,0.00993629,0.00009673499,0.000019005716,0.00009253363,0.002710215,0.00004568627,0.002487006],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99967074,0.000118717435,0.000020252328,0.00006784835,0.00006651117,0.00005591836],"domain_scores_gemma":[0.99952626,0.00028658827,0.00004945352,0.000033192722,0.00007630522,0.000028296578],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006299066,0.0010286645,0.0010546438,0.00035759975,0.00025449635,0.00094736624,0.00078152696,0.00047277712,0.0043177167],"category_scores_gemma":[0.0010454311,0.0005394915,0.0009806275,0.00035720825,0.00019153446,0.0003251623,0.00039229094,0.000623637,0.00093997474],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0039508888,0.0019975118,0.0095208045,0.0037916182,0.00067275116,0.0015162048,0.00019109905,0.50061566,0.43339053,0.003259207,0.0022246907,0.03886911],"study_design_scores_gemma":[0.0007795222,0.008978567,0.0036665981,0.0001751128,0.0010851894,0.0004944206,0.00020159165,0.45709977,0.5148779,0.0010049406,0.011509426,0.00012703064],"about_ca_topic_score_codex":0.0019179882,"about_ca_topic_score_gemma":0.0030600894,"teacher_disagreement_score":0.0043177167,"about_ca_system_score_codex":0.0004344497,"about_ca_system_score_gemma":0.00055185053,"threshold_uncertainty_score":0.014444232},"labels":[],"label_agreement":null},{"id":"W2278298054","doi":"10.1016/j.bmcl.2016.01.059","title":"Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Austrian Science Fund; European Molecular Biology Organization","keywords":"Chemistry; Stereochemistry; Hydroxymethyl; Glycoside hydrolase; Beta-galactosidase; Enzyme; Biochemistry","score_opus":0.007881279883259332,"score_gpt":0.24736074747289732,"score_spread":0.239479467589638,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2278298054","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9725071,0.0036286113,0.014662294,0.00017243483,0.00008804639,0.00011022869,0.0006923461,0.00014398608,0.007995009],"genre_scores_gemma":[0.9928336,0.0010149892,0.0033913576,0.00003965666,0.000009362967,0.000029526027,0.00032793777,0.000012056503,0.0023415256],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999392,0.000009202084,0.0000056403555,0.000009098129,0.000009761045,0.000027064874],"domain_scores_gemma":[0.9999498,0.0000048908687,0.000012032793,0.0000053587364,0.000008253102,0.000019661129],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117288844,0.00034121517,0.00023189127,0.00017053715,0.00010576781,0.0001626528,0.00038768194,0.00025726826,0.0011028491],"category_scores_gemma":[0.00009656181,0.00010197299,0.00020473263,0.00017238801,0.00012564505,0.00020648762,0.0001842824,0.00036167796,0.00041125275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024298238,0.000053051863,0.00010500724,0.00007193637,0.000013926245,0.0002294488,0.00004072064,0.0005630016,0.99228865,0.0007018873,0.00010381763,0.005585449],"study_design_scores_gemma":[0.000039222727,0.00063031306,0.0007977009,0.0000053980107,0.00002130724,0.00025756634,0.000010780543,0.00061329507,0.9922098,0.000096080614,0.0053066784,0.000011883549],"about_ca_topic_score_codex":0.00059008074,"about_ca_topic_score_gemma":0.000578603,"teacher_disagreement_score":0.0011028491,"about_ca_system_score_codex":0.00026892452,"about_ca_system_score_gemma":0.0002514312,"threshold_uncertainty_score":0.0036893487},"labels":[],"label_agreement":null},{"id":"W2279267781","doi":"10.1016/j.bmcl.2016.02.062","title":"Synthesis and evaluation of 18F-trifluoroborate derivatives of triphenylphosphonium for myocardial perfusion imaging","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; In vivo; Phosphonium; Radiochemistry; Yield (engineering); Positron emission tomography; Myocardial perfusion imaging; Aqueous solution; Perfusion; Nuclear chemistry; Nuclear medicine; Organic chemistry; Internal medicine","score_opus":0.027239397245476537,"score_gpt":0.3031036879557661,"score_spread":0.27586429071028956,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2279267781","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95893675,0.007170161,0.024250327,0.00046279692,0.00011725428,0.00038570495,0.00073636527,0.0002219187,0.0077187605],"genre_scores_gemma":[0.9754778,0.0034322129,0.016141282,0.00016790729,0.00002865157,0.00015071336,0.0009947015,0.00007287883,0.0035338642],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981314,0.0000500587,0.000015799693,0.000032329666,0.000027484974,0.000061120714],"domain_scores_gemma":[0.9998467,0.000025131141,0.000044553974,0.000016956841,0.000029585382,0.000037034104],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004705832,0.0005273947,0.00033247587,0.00030838276,0.00028259473,0.0003271879,0.0006519252,0.00076734397,0.0017763316],"category_scores_gemma":[0.00042904666,0.00032289673,0.00032077162,0.0002473036,0.00019673225,0.00043587855,0.00023411507,0.0005306491,0.0006373415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000625582,0.00008892207,0.00008927853,0.000146172,0.00003277015,0.00026742608,0.00006575306,0.00048737103,0.9912874,0.00037205173,0.00021134233,0.0063260347],"study_design_scores_gemma":[0.00009317591,0.0010107266,0.0002567456,0.00001369944,0.000055038054,0.0003112473,0.000014864732,0.00057057006,0.994079,0.000034772667,0.0035441795,0.000016081653],"about_ca_topic_score_codex":0.001052722,"about_ca_topic_score_gemma":0.0012430908,"teacher_disagreement_score":0.0017763316,"about_ca_system_score_codex":0.00039661885,"about_ca_system_score_gemma":0.0003176747,"threshold_uncertainty_score":0.005942464},"labels":[],"label_agreement":null},{"id":"W2302032128","doi":"10.1016/j.bmcl.2016.03.069","title":"Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging","year":2016,"lang":"en","type":"letter","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Prostate Cancer Canada","keywords":"Chemistry; Hydroxysteroid dehydrogenase; Stereochemistry; Enzyme inhibitor; Biochemistry; Dehydrogenase; Enzyme","score_opus":0.007526154577097521,"score_gpt":0.2223893410352451,"score_spread":0.2148631864581476,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2302032128","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7342371,0.014987321,0.16849838,0.014621206,0.0029801824,0.0011960249,0.003240061,0.0016373731,0.058602344],"genre_scores_gemma":[0.91738623,0.0062853685,0.051760852,0.001506888,0.00021423785,0.0002801128,0.0013830323,0.00017990965,0.021003434],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984336,0.000017483306,0.000010396906,0.000036640522,0.000034491364,0.000057696758],"domain_scores_gemma":[0.9998431,0.00004694749,0.00003217506,0.000025228039,0.0000183547,0.00003410591],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035462243,0.0005383203,0.0004038117,0.00015816784,0.00037205362,0.00039505906,0.00067946105,0.0012107809,0.0020770126],"category_scores_gemma":[0.00027903318,0.00036026328,0.00036178433,0.00017794251,0.00033113212,0.00058103347,0.00029750657,0.0012095338,0.0011515778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002561825,0.00012710688,0.00010623722,0.00017155214,0.000015376096,0.000930336,0.00007824318,0.00075007183,0.9818117,0.0030164297,0.0025530194,0.010183825],"study_design_scores_gemma":[0.0000809477,0.00027933443,0.00015272465,0.0000059353524,0.00001629201,0.0004948571,0.000008039534,0.0019160201,0.97283363,0.00036854093,0.023824627,0.000019069335],"about_ca_topic_score_codex":0.00087420776,"about_ca_topic_score_gemma":0.0015686555,"teacher_disagreement_score":0.0020770126,"about_ca_system_score_codex":0.00073408656,"about_ca_system_score_gemma":0.00059380574,"threshold_uncertainty_score":0.0069482923},"labels":[],"label_agreement":null},{"id":"W2308745546","doi":"10.1016/j.bmcl.2016.02.029","title":"Design and synthesis of [125I]Pyricoxib: A novel 125I-labeled cyclooxygenase-2 (COX-2) inhibitors","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cyclooxygenase; Prostaglandin-Endoperoxide Synthase; Enzyme inhibitor; Pharmacology; Stereochemistry; Enzyme; Biochemistry","score_opus":0.010784583186875125,"score_gpt":0.21168149850253826,"score_spread":0.20089691531566314,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2308745546","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7658579,0.01690822,0.18039854,0.0014199989,0.00044459646,0.0022157754,0.0028184357,0.00077951374,0.029157083],"genre_scores_gemma":[0.91390175,0.007246247,0.06380294,0.00033498573,0.00007305664,0.000691146,0.0016340099,0.00007877415,0.012237131],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998702,0.000022952026,0.000010461667,0.000027019862,0.000027892085,0.000041438183],"domain_scores_gemma":[0.999928,0.000007336136,0.000017651793,0.000007726853,0.000013656676,0.00002559865],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002919821,0.00053903577,0.00033025065,0.0002702737,0.00027155536,0.00045707883,0.0006437473,0.0004812353,0.0020269926],"category_scores_gemma":[0.00019370107,0.0003898119,0.00025432947,0.00024220214,0.00025105846,0.00035510497,0.0002607937,0.000764103,0.00092327426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000586721,0.0002277266,0.00017082274,0.00032607577,0.000032415206,0.00040923743,0.00011777055,0.0043193083,0.96989965,0.0038155837,0.0012388723,0.018855758],"study_design_scores_gemma":[0.00023134031,0.0010031151,0.00033525392,0.000015579912,0.000043445674,0.00042812986,0.000016100414,0.00299459,0.96777713,0.00022651684,0.026901359,0.000027477725],"about_ca_topic_score_codex":0.0010484478,"about_ca_topic_score_gemma":0.0018190927,"teacher_disagreement_score":0.0020269926,"about_ca_system_score_codex":0.00069712265,"about_ca_system_score_gemma":0.0005980264,"threshold_uncertainty_score":0.006780982},"labels":[],"label_agreement":null},{"id":"W2339098831","doi":"10.1016/j.bmcl.2016.04.053","title":"Novel nucleoside-based antimalarial compounds","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Nucleoside; Antimalarial Agent; Plasmodium falciparum; Malaria; Combinatorial chemistry; Stereochemistry","score_opus":0.012835334703087684,"score_gpt":0.22763125964047032,"score_spread":0.21479592493738264,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2339098831","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.72599775,0.11089929,0.023114514,0.001802239,0.0013021262,0.0006449768,0.0020856145,0.0007524265,0.13340098],"genre_scores_gemma":[0.8977573,0.044906974,0.023374882,0.0010402655,0.0002765574,0.00024661413,0.0015949574,0.00004755822,0.030754972],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999609,0.000008699976,0.0000029238422,0.000007396626,0.00000894804,0.000011110854],"domain_scores_gemma":[0.99997854,0.0000039097904,0.0000028827662,0.0000022631536,0.0000046319465,0.0000077555205],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010557797,0.0004368234,0.00028708333,0.0002881105,0.0002599742,0.0003799356,0.00044501814,0.00034178328,0.005014398],"category_scores_gemma":[0.00009430466,0.00015593506,0.00016281292,0.00016002175,0.00015919794,0.00028338336,0.00026930065,0.0005190579,0.001330211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007052804,0.00031679013,0.00019312854,0.0006179677,0.000052607313,0.00075661246,0.000082923376,0.0012192221,0.8718455,0.0074341823,0.0028586215,0.113917135],"study_design_scores_gemma":[0.00051340077,0.004400353,0.0019559362,0.00013402558,0.00015750651,0.002368392,0.000050110895,0.0040371977,0.79244065,0.002117628,0.19177368,0.0000511339],"about_ca_topic_score_codex":0.00033265247,"about_ca_topic_score_gemma":0.0013014872,"teacher_disagreement_score":0.005014398,"about_ca_system_score_codex":0.00030980993,"about_ca_system_score_gemma":0.00020866453,"threshold_uncertainty_score":0.016774833},"labels":[],"label_agreement":null},{"id":"W234567464","doi":"10.1016/j.bmcl.2015.05.036","title":"Use of molecular modeling aided design to dial out hERG liability in adenosine A2A receptor antagonists","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre","funders":"","keywords":"hERG; Chemistry; Docking (animal); Molecular model; Lead compound; Quinazoline; Pharmacology; Stereochemistry; Combinatorial chemistry; Biochemistry; Biophysics; Potassium channel; In vitro","score_opus":0.06421880525581727,"score_gpt":0.26592452082491325,"score_spread":0.20170571556909597,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W234567464","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7490453,0.0011256307,0.23189324,0.0005861489,0.00011598906,0.00048787685,0.00068948144,0.0018655462,0.01419071],"genre_scores_gemma":[0.9096211,0.0007240641,0.086839676,0.00014630744,0.0000117695,0.00026541288,0.00032937457,0.00016755621,0.0018945333],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9997968,0.000065888074,0.000010934424,0.000023202723,0.000069767106,0.00003337911],"domain_scores_gemma":[0.9998217,0.000087322325,0.0000341057,0.000012833524,0.000033333534,0.000010668017],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000616429,0.00086089125,0.00071431865,0.0002871945,0.00035109805,0.00066228455,0.0005377982,0.00038910646,0.0019450412],"category_scores_gemma":[0.00072911446,0.0004383593,0.00048211683,0.00021040747,0.00021612161,0.00035828596,0.0003066983,0.0007893351,0.00027172163],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010418372,0.0006774936,0.0017970258,0.00041013802,0.00019653054,0.00052373216,0.00014923989,0.75260854,0.14237991,0.027956594,0.0017134482,0.0705455],"study_design_scores_gemma":[0.00029401248,0.00093443407,0.0003076509,0.000020132078,0.00012086507,0.00008910816,0.000037450143,0.9111299,0.08005334,0.001993552,0.0049801986,0.000039383594],"about_ca_topic_score_codex":0.0019858794,"about_ca_topic_score_gemma":0.0038391137,"teacher_disagreement_score":0.0019858794,"about_ca_system_score_codex":0.00061244634,"about_ca_system_score_gemma":0.0010647695,"threshold_uncertainty_score":0.0065068603},"labels":[],"label_agreement":null},{"id":"W239606103","doi":"10.1016/j.bmcl.2011.02.051","title":"Reprint of “Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” [Bioorg. Med. Chem. Lett. 21 (2011) 2591–2596]","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta; Alberta Glycomics Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Chemistry; Stereochemistry; Cytotoxicity; Steric effects; Moiety; Carbohydrate; Furan; In vitro; Biochemistry; Organic chemistry","score_opus":0.019900178744270212,"score_gpt":0.20386201799104842,"score_spread":0.1839618392467782,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W239606103","genre_codex":"editorial","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.033113074,0.05776452,0.00788783,0.06642294,0.66218734,0.00028693824,0.020957915,0.0019323048,0.14944707],"genre_scores_gemma":[0.18700214,0.046603557,0.007559281,0.037329067,0.07470958,0.00028612878,0.02937132,0.0006482892,0.61649066],"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99970347,0.00003876154,0.00003838939,0.00003692245,0.00013461076,0.000047737383],"domain_scores_gemma":[0.99936527,0.00026960735,0.00008635786,0.00007076794,0.00012835897,0.000079639634],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030391102,0.000990641,0.00076727703,0.00070865365,0.0005431186,0.00069990323,0.00092236476,0.0012283343,0.060317453],"category_scores_gemma":[0.0014077888,0.00039857332,0.0007337833,0.00058499136,0.0005052374,0.0005771907,0.00027044848,0.0021827538,0.016966142],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019586214,0.00028354744,0.00033204444,0.0014902672,0.00014965802,0.0014435023,0.00007787017,0.0006645301,0.11202859,0.004392542,0.8196339,0.05754488],"study_design_scores_gemma":[0.00019678206,0.0006694065,0.0049034343,0.00007864292,0.00006308912,0.0008813417,0.0000390447,0.00047840024,0.06867269,0.0013804126,0.92259294,0.000043911863],"about_ca_topic_score_codex":0.0014449436,"about_ca_topic_score_gemma":0.0029418028,"teacher_disagreement_score":0.060317453,"about_ca_system_score_codex":0.0004304549,"about_ca_system_score_gemma":0.00039924032,"threshold_uncertainty_score":0.20178199},"labels":[],"label_agreement":null},{"id":"W2413557253","doi":"10.1016/j.bmcl.2016.06.021","title":"Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Potency; Bioavailability; Kinase; Tyrosine kinase; Moiety; Selectivity; Pharmacokinetics; Pharmacology; Stereochemistry; Structure–activity relationship; Threonine; Tyrosine-kinase inhibitor; Cancer; Biochemistry; Enzyme; In vitro; Signal transduction; Serine; Internal medicine; Medicine","score_opus":0.00882445863781131,"score_gpt":0.21039436226077637,"score_spread":0.20156990362296506,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2413557253","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9479908,0.022710912,0.016624693,0.00082371687,0.00019015376,0.00029126936,0.00072262937,0.00030057228,0.010345331],"genre_scores_gemma":[0.98136705,0.0078849895,0.0046095643,0.00013036159,0.00005491504,0.00006939587,0.000441228,0.000015353751,0.0054270606],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999263,0.000015597072,0.000004184345,0.0000118151065,0.000017625825,0.000024470008],"domain_scores_gemma":[0.9999579,0.0000064631768,0.000012407316,0.000003352652,0.000009638401,0.000010262305],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023265045,0.00034012634,0.00025058782,0.00022174322,0.00010822662,0.00039869966,0.00032710028,0.00024512698,0.0011225075],"category_scores_gemma":[0.00015577888,0.00016108189,0.00017097007,0.00011070689,0.00018749184,0.00023035512,0.00018518425,0.00037699603,0.0003684902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003777237,0.00016316668,0.000337024,0.00023268863,0.000022036094,0.00030681584,0.00007183371,0.0009670911,0.97134227,0.0013994056,0.00074848667,0.024031525],"study_design_scores_gemma":[0.0006141593,0.0035107576,0.004093105,0.00003762271,0.000091043185,0.0011056685,0.00004632485,0.0040251478,0.95424473,0.00040475623,0.031795476,0.00003127706],"about_ca_topic_score_codex":0.00044092242,"about_ca_topic_score_gemma":0.0017562947,"teacher_disagreement_score":0.0011225075,"about_ca_system_score_codex":0.00029277292,"about_ca_system_score_gemma":0.00023100307,"threshold_uncertainty_score":0.0037551522},"labels":[],"label_agreement":null},{"id":"W2419568648","doi":"10.1016/j.bmcl.2016.06.003","title":"[Dmt1]DALDA analogues modified with tyrosine analogues at position 1","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Free Radicals and Antioxidants","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute on Drug Abuse; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine; National Natural Science Foundation of China","keywords":"Chemistry; Isopropyl; Antioxidant; Pharmacology; Agonist; Opioid; DMT1; Peptide; Stereochemistry; Opioid peptide; Oligopeptide; Receptor; Biochemistry; Transporter; Medicinal chemistry","score_opus":0.009444919048245631,"score_gpt":0.19644349127308205,"score_spread":0.18699857222483643,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2419568648","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99328035,0.00095506053,0.0015173241,0.000081716214,0.000074259275,0.00004055892,0.0002635883,0.00006273651,0.0037245094],"genre_scores_gemma":[0.99576217,0.00045595938,0.0013681024,0.000039791656,0.000008524024,0.000020609747,0.00032121188,0.000012328302,0.0020112807],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999087,0.000012600232,0.000006547758,0.00002116995,0.000012137381,0.000038871898],"domain_scores_gemma":[0.9999378,0.000008569056,0.000019485613,0.000007619419,0.000010061107,0.000016604103],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011333646,0.0002983806,0.00030696948,0.000113788345,0.00015801121,0.0001576825,0.00042141677,0.00032219652,0.002335527],"category_scores_gemma":[0.00015550165,0.00010034493,0.00010855488,0.00020145466,0.00015895464,0.00017947065,0.000104769024,0.0004029532,0.000309812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009348487,0.00006442365,0.00014331011,0.00014354591,0.000022468947,0.00014630091,0.0000363919,0.0004055389,0.99278826,0.0005677016,0.00024785203,0.0044993237],"study_design_scores_gemma":[0.00008943586,0.00080777926,0.000728605,0.000006720047,0.00002650932,0.00013543697,0.000016370763,0.0006173164,0.99230725,0.00007246165,0.0051797656,0.000012367404],"about_ca_topic_score_codex":0.00087299326,"about_ca_topic_score_gemma":0.0008944026,"teacher_disagreement_score":0.002335527,"about_ca_system_score_codex":0.00032398116,"about_ca_system_score_gemma":0.00016706884,"threshold_uncertainty_score":0.007813096},"labels":[],"label_agreement":null},{"id":"W2464362473","doi":"10.1016/j.bmcl.2016.07.025","title":"Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Instituto Nacional de Ciência e Tecnologia de Gestão da Inovação em Doenças Negligenciadas; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Allard Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Cancer Society","keywords":"Chemistry; Colchicine; Moiety; Tubulin; Stereochemistry; Pyrazole; Cytotoxicity; Docking (animal); Mechanism of action; Biological activity; Microtubule; In vitro; In silico; Biochemistry","score_opus":0.02528215668527806,"score_gpt":0.28340994545459935,"score_spread":0.2581277887693213,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2464362473","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97772187,0.010317798,0.0041884887,0.00028738045,0.0000550833,0.00026580246,0.0013945121,0.00013096418,0.005638018],"genre_scores_gemma":[0.98219717,0.007226044,0.00538246,0.00006972448,0.000021306952,0.000089724344,0.0012788182,0.00001656724,0.0037181678],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999331,0.00001519579,0.0000046952496,0.000010972499,0.000018535251,0.000017529203],"domain_scores_gemma":[0.99996173,0.000007389821,0.000009234836,0.0000043298664,0.000008151091,0.000009315374],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015309529,0.00029591253,0.00044675253,0.00025937628,0.00022561352,0.00026156014,0.00030809714,0.00020633353,0.0023936373],"category_scores_gemma":[0.00013605566,0.00019780625,0.00029514616,0.00021175973,0.00013950751,0.00012978457,0.00012912822,0.00037409205,0.00040609125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008211912,0.00044262226,0.00055684935,0.00042782305,0.00004080718,0.0004188302,0.000068756504,0.0056066364,0.9705993,0.00063810404,0.000518321,0.019860711],"study_design_scores_gemma":[0.0006502717,0.009149926,0.006469495,0.000065314285,0.00027041518,0.001008661,0.0000823288,0.014011721,0.9487879,0.00025320653,0.019194603,0.000056164834],"about_ca_topic_score_codex":0.001448238,"about_ca_topic_score_gemma":0.005178929,"teacher_disagreement_score":0.0023936373,"about_ca_system_score_codex":0.0003147865,"about_ca_system_score_gemma":0.00033697032,"threshold_uncertainty_score":0.008007526},"labels":[],"label_agreement":null},{"id":"W2470832783","doi":"10.1016/j.bmcl.2016.06.068","title":"Corrigendum to “Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay” [Bioorg. Med. Chem. Lett. 25 (2015) 2505–2509]","year":2016,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development","funders":"","keywords":"Chemistry; Prodrug; Bioavailability; Pharmacology; Biochemistry; Medicine","score_opus":0.034629213017386654,"score_gpt":0.30916301475585434,"score_spread":0.2745338017384677,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2470832783","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00015743764,0.0038221902,0.0005203796,0.035914507,0.94957167,0.00007175217,0.0012157424,0.00034700707,0.008379419],"genre_scores_gemma":[0.008981146,0.023958987,0.0035972444,0.09913553,0.25666738,0.00031985078,0.005399153,0.0007061716,0.6012345],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.995682,0.0004424499,0.0006340341,0.0005679046,0.0020768053,0.0005967531],"domain_scores_gemma":[0.9889976,0.002353473,0.00078837073,0.00067107374,0.0064002136,0.0007893194],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002893597,0.0036083094,0.0032065986,0.0034672618,0.003403876,0.0030792917,0.0052367123,0.009735682,0.0927516],"category_scores_gemma":[0.019949446,0.0018847325,0.0031971843,0.0028153036,0.0023918834,0.0023368406,0.0025913331,0.007301533,0.071978174],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003715307,0.000023090832,0.000044871176,0.00018541224,0.00001185268,0.0002574285,0.00001253111,0.00006330488,0.00028069504,0.0003251152,0.9926724,0.006086177],"study_design_scores_gemma":[0.000048345795,0.000069311354,0.001234797,0.00017021291,0.000050866736,0.0003153835,0.00003719872,0.00024049236,0.0015151848,0.00066173985,0.9956044,0.00005220303],"about_ca_topic_score_codex":0.029917823,"about_ca_topic_score_gemma":0.04487001,"teacher_disagreement_score":0.0927516,"about_ca_system_score_codex":0.006334325,"about_ca_system_score_gemma":0.005422978,"threshold_uncertainty_score":0.31028497},"labels":[],"label_agreement":null},{"id":"W2471316642","doi":"10.1016/j.bmcl.2016.06.066","title":"Design, synthesis and evaluation of 18F-labeled bradykinin B1 receptor-targeting small molecules for PET imaging","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Bradykinin; Small molecule; Receptor; Bradykinin receptor; Pet imaging; Chemical synthesis; Positron emission tomography; Stereochemistry; Pharmacology; Biophysics; In vitro; Biochemistry; Nuclear medicine","score_opus":0.030774566912873384,"score_gpt":0.26275467576312994,"score_spread":0.23198010885025655,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2471316642","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9213635,0.007236466,0.06317997,0.00043787694,0.000097572025,0.0011653897,0.00071087625,0.00019725265,0.0056111757],"genre_scores_gemma":[0.9386316,0.0054552695,0.048429426,0.00019096142,0.00003456735,0.00049243186,0.000807698,0.000060225273,0.005897824],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998822,0.000022746597,0.000009704706,0.000024627701,0.00003312866,0.000027552325],"domain_scores_gemma":[0.99989176,0.000020551877,0.00003182876,0.000008466241,0.00002212391,0.000025156683],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003850016,0.00035606127,0.00027552777,0.00020373327,0.00023886647,0.00042209824,0.00037303363,0.0004254285,0.00097380206],"category_scores_gemma":[0.0003301892,0.00024873237,0.00022125368,0.00015484927,0.00018363744,0.0003932482,0.0001546079,0.00036164347,0.00045546415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022017008,0.00010633629,0.00010291262,0.00016534778,0.000015174056,0.0002286269,0.00006425041,0.0016536317,0.9859547,0.00089582574,0.00019906461,0.010393991],"study_design_scores_gemma":[0.00008877037,0.0009418567,0.0003305055,0.000008468804,0.000028520022,0.00029332621,0.000016425347,0.002284939,0.9883711,0.000076603625,0.0075456905,0.000013863872],"about_ca_topic_score_codex":0.00054201344,"about_ca_topic_score_gemma":0.00086509075,"teacher_disagreement_score":0.00097380206,"about_ca_system_score_codex":0.000462522,"about_ca_system_score_gemma":0.00029712755,"threshold_uncertainty_score":0.003355801},"labels":[],"label_agreement":null},{"id":"W2482157428","doi":"10.1016/j.bmcl.2016.07.041","title":"New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Engineering and Physical Sciences Research Council; University College London; Ontario Genomics Institute; Genome Canada","keywords":"Nitrile; Chemistry; Halogen; Stereochemistry; Transferase; Small molecule; Molecule; Polar; Methyl group; Group (periodic table); Combinatorial chemistry; Organic chemistry; Biochemistry; Enzyme; Alkyl","score_opus":0.012592206060101772,"score_gpt":0.24799769841171754,"score_spread":0.23540549235161576,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2482157428","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9535401,0.012645961,0.019131834,0.00055113155,0.0002636982,0.0003322256,0.0007881513,0.0009470478,0.0117998095],"genre_scores_gemma":[0.9785418,0.0042873397,0.0065113725,0.00022383686,0.00002759998,0.00014051412,0.00082659035,0.000038182636,0.009402837],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992955,0.000008635658,0.000003417184,0.000014870562,0.000019982723,0.000023426493],"domain_scores_gemma":[0.9999621,0.000005139997,0.00001044323,0.0000040479076,0.0000052580913,0.000012998048],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019712694,0.0004044109,0.00036312226,0.00014416622,0.00014989557,0.0002071836,0.0005820198,0.00028881148,0.0014853085],"category_scores_gemma":[0.000085347885,0.00014871066,0.00020757552,0.00011821846,0.00020022086,0.0001907135,0.00030286858,0.0006317556,0.00040686986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00063128077,0.00014956186,0.0003545755,0.0001707218,0.000060021644,0.00018282163,0.00003898702,0.0008731612,0.9732633,0.0014220069,0.0011208794,0.021732718],"study_design_scores_gemma":[0.00046233003,0.0020063557,0.001579028,0.000014130241,0.00007473685,0.0005280428,0.000021842037,0.0029436923,0.9661547,0.00021224073,0.025978515,0.000024437697],"about_ca_topic_score_codex":0.0006651208,"about_ca_topic_score_gemma":0.0024721986,"teacher_disagreement_score":0.0014853085,"about_ca_system_score_codex":0.00041638355,"about_ca_system_score_gemma":0.00021427782,"threshold_uncertainty_score":0.0049688816},"labels":[],"label_agreement":null},{"id":"W2510705586","doi":"10.1016/j.bmcl.2016.08.063","title":"Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Chemistry; Indazole; In vivo; Cyclopropane; Moiety; Aryl; Stereochemistry; Bioavailability; Pharmacology; In vitro; Biochemistry; Organic chemistry; Ring (chemistry); Alkyl","score_opus":0.0065806870693696645,"score_gpt":0.20648473969933187,"score_spread":0.1999040526299622,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2510705586","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9691405,0.007509548,0.012593505,0.0002944608,0.0000925948,0.00047723236,0.001173439,0.00026320913,0.008455565],"genre_scores_gemma":[0.97889644,0.004301471,0.009998373,0.00011663503,0.00002156848,0.00021907121,0.0012022431,0.00003999991,0.0052041695],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999025,0.000014501637,0.000009849143,0.000017436085,0.000024843173,0.000030923846],"domain_scores_gemma":[0.9999447,0.0000056643526,0.000018800247,0.000004045359,0.00001061584,0.000016206995],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021773473,0.0004202486,0.00040319204,0.00031425516,0.00016285888,0.0004160715,0.00048158984,0.00017715395,0.0018829197],"category_scores_gemma":[0.0001513291,0.0002556798,0.0002255823,0.00023461806,0.00014588523,0.0001904393,0.00023579586,0.00043363747,0.00056647975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011270054,0.0005589661,0.00057089457,0.00044560304,0.000048225975,0.00032174378,0.00008700036,0.0075062895,0.9491846,0.001671803,0.0008786381,0.03759931],"study_design_scores_gemma":[0.0010464109,0.004639244,0.0031206843,0.000043913762,0.00020517578,0.00048921065,0.000046210604,0.0090282345,0.95232165,0.00027630624,0.02872961,0.000053432366],"about_ca_topic_score_codex":0.0005424607,"about_ca_topic_score_gemma":0.0019767352,"teacher_disagreement_score":0.0018829197,"about_ca_system_score_codex":0.00042838033,"about_ca_system_score_gemma":0.0005164322,"threshold_uncertainty_score":0.0062989593},"labels":[],"label_agreement":null},{"id":"W2512770795","doi":"10.1016/j.bmcl.2016.08.011","title":"Facile synthesis and 18F-radiolabeling of α4β1-specific LLP2A-aryltrifluoroborate peptidomimetic conjugates","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TRIUMF; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Chemistry; Conjugate; Peptidomimetic; Imaging agent; Radiosynthesis; Molecular imaging; Combinatorial chemistry; Positron emission tomography; Peptide; In vivo; Biochemistry; Nuclear medicine; Biology","score_opus":0.016095552865528513,"score_gpt":0.23788214847641934,"score_spread":0.2217865956108908,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2512770795","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9016302,0.0048833294,0.075690955,0.0005045202,0.00014498607,0.00044106203,0.0015084732,0.0008009958,0.0143954465],"genre_scores_gemma":[0.9310473,0.002774761,0.051829625,0.00018534811,0.00004806961,0.00035849446,0.0012499704,0.00012255633,0.012383898],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982566,0.000032114414,0.00001332352,0.000037949452,0.000039218005,0.000051805153],"domain_scores_gemma":[0.9999068,0.000021385407,0.000025012854,0.000011342701,0.000013600057,0.00002190395],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189663,0.00053195213,0.00034224498,0.00022335994,0.00027859694,0.0002740771,0.000339471,0.00040936118,0.0024547519],"category_scores_gemma":[0.00022553414,0.00031656757,0.00017050626,0.00020668027,0.00015627817,0.0002490197,0.0002451228,0.00056426827,0.0012256135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000077475146,0.000013590796,0.000031512245,0.00004041235,0.0000037948125,0.00011289081,0.000021082664,0.00016325037,0.99632555,0.00018300411,0.00012784728,0.002899681],"study_design_scores_gemma":[0.000021320604,0.00013851933,0.00019029524,0.000003478366,0.000006697574,0.00025376267,0.0000075672087,0.00056255487,0.9926845,0.000027560904,0.0060975575,0.0000061282417],"about_ca_topic_score_codex":0.0006413397,"about_ca_topic_score_gemma":0.0015711609,"teacher_disagreement_score":0.0024547519,"about_ca_system_score_codex":0.00043684128,"about_ca_system_score_gemma":0.0003104921,"threshold_uncertainty_score":0.00821197},"labels":[],"label_agreement":null},{"id":"W2513174079","doi":"10.1016/j.bmcl.2016.09.008","title":"Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure–activity relationship of anabaenopeptin protease inhibitors","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University","funders":"National Oceanic and Atmospheric Administration","keywords":"Cyanobacteria; Chemistry; Algal bloom; Carboxypeptidase; Protease; Enzyme; Bacteria; Biochemistry; Stereochemistry; Biology; Organic chemistry; Phytoplankton","score_opus":0.00836835519791803,"score_gpt":0.20905945036427792,"score_spread":0.20069109516635988,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2513174079","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9815819,0.0045721573,0.0078661535,0.00026089905,0.00003392683,0.000097939264,0.0008266402,0.000036884303,0.00472342],"genre_scores_gemma":[0.9825324,0.003933192,0.007752119,0.00008065196,0.000007827243,0.00002042095,0.00083189644,0.000008952624,0.004832544],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995136,0.000006047991,0.000004249891,0.000007833597,0.000019725954,0.000010790722],"domain_scores_gemma":[0.99996614,0.00000666533,0.0000063843863,0.0000024301987,0.000008848733,0.000009447153],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011770811,0.00022727683,0.0001723931,0.00022982268,0.00014392585,0.00029971977,0.0001315452,0.0001738096,0.0007398108],"category_scores_gemma":[0.00010674476,0.00011218092,0.00018412802,0.0002213288,0.00013556369,0.00021901897,0.0001369726,0.0003711186,0.0002999882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006495779,0.000016619088,0.00024107487,0.00003307367,0.0000044046274,0.00009041756,0.0000092326845,0.00016750286,0.9956298,0.00014048812,0.000028424924,0.0035740982],"study_design_scores_gemma":[0.000016081567,0.00019631871,0.0031101229,0.000006557638,0.000011883967,0.00018584423,0.000030524643,0.0004927236,0.9916979,0.00008506621,0.004162826,0.000004118363],"about_ca_topic_score_codex":0.0010553161,"about_ca_topic_score_gemma":0.0022823492,"teacher_disagreement_score":0.0010553161,"about_ca_system_score_codex":0.00030186825,"about_ca_system_score_gemma":0.00038936327,"threshold_uncertainty_score":0.002474904},"labels":[],"label_agreement":null},{"id":"W2516941967","doi":"10.1016/j.bmcl.2016.09.011","title":"Synthesis of a selective HDAC6 inhibitor active in neuroblasts","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Université de Poitiers; Université de Genève; Ligue Contre le Cancer; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Centre National de la Recherche Scientifique; European Cooperation in Science and Technology","keywords":"HDAC6; Chemistry; IC50; In vitro; In silico; Neurodegeneration; Biochemistry; Pharmacology; Histone deacetylase; Biology; Disease","score_opus":0.006151684792005515,"score_gpt":0.23257032402770716,"score_spread":0.22641863923570166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2516941967","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8552213,0.020347092,0.06951755,0.00081956305,0.0005654702,0.0009811159,0.00905082,0.0011253817,0.042371802],"genre_scores_gemma":[0.93084925,0.012340017,0.029604992,0.00022597889,0.0000698245,0.00019288504,0.0043127094,0.000113668655,0.022290658],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993443,0.000004402006,0.0000071183163,0.000014257672,0.000015742798,0.00002395831],"domain_scores_gemma":[0.9999614,0.0000031289148,0.000005705542,0.0000049434134,0.000009266054,0.000015554688],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012740966,0.0005387192,0.00039700393,0.00026987202,0.0002814187,0.00020145641,0.00045838696,0.00030833247,0.0025565142],"category_scores_gemma":[0.000053740587,0.00021125496,0.0003077278,0.00024971823,0.00011030173,0.00016092193,0.0001855349,0.00056797714,0.0013369406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018587793,0.0000502383,0.00007459816,0.00013804347,0.000016113761,0.00012338253,0.000020763855,0.00026568738,0.9905222,0.00026381292,0.00028675128,0.008052557],"study_design_scores_gemma":[0.00003869081,0.00019890004,0.00035489298,0.00000414252,0.000027365415,0.00010344082,0.0000066219445,0.00018373856,0.9908987,0.00003196633,0.008146829,0.0000045287425],"about_ca_topic_score_codex":0.0013191521,"about_ca_topic_score_gemma":0.0023595213,"teacher_disagreement_score":0.0025565142,"about_ca_system_score_codex":0.00031111937,"about_ca_system_score_gemma":0.00054287276,"threshold_uncertainty_score":0.008552372},"labels":[],"label_agreement":null},{"id":"W2517714550","doi":"10.1016/j.bmcl.2016.08.018","title":"Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Allosteric regulation; Chemistry; Cannabinoid receptor; Indole test; Cannabinoid; Allosteric modulator; Pharmacology; Receptor; Biochemistry; Biology; Antagonist","score_opus":0.01266882609604844,"score_gpt":0.2569338465363151,"score_spread":0.24426502044026668,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2517714550","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9246756,0.018885307,0.021219358,0.0010325426,0.00042176535,0.0003381635,0.0005403745,0.00058325636,0.032303672],"genre_scores_gemma":[0.9735735,0.010003186,0.0066195633,0.00028236472,0.000043689884,0.00009041926,0.00034331015,0.000024297493,0.009019784],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999409,0.000010129243,0.0000039973597,0.000009700925,0.00001413745,0.000021088938],"domain_scores_gemma":[0.99996614,0.0000050729886,0.0000070492088,0.0000034583068,0.000008605021,0.000009763533],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810503,0.00030573984,0.00022014011,0.00020018633,0.0001679148,0.00022894087,0.0003977258,0.00020386212,0.0023777324],"category_scores_gemma":[0.00015301706,0.00012450607,0.00022788421,0.0001321425,0.00017991611,0.00024340779,0.0002263886,0.00044091992,0.00046057077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008758085,0.00038172037,0.00058552285,0.00035159642,0.000040710336,0.00048824504,0.00026240948,0.0016815203,0.88879037,0.008286166,0.0023674031,0.09588852],"study_design_scores_gemma":[0.0005355915,0.0054356405,0.0027969729,0.00006547948,0.00012377814,0.0008971156,0.000134434,0.0067213858,0.89359474,0.0013830506,0.08825964,0.00005208614],"about_ca_topic_score_codex":0.0008925131,"about_ca_topic_score_gemma":0.0025727407,"teacher_disagreement_score":0.0023777324,"about_ca_system_score_codex":0.00037632298,"about_ca_system_score_gemma":0.00033627328,"threshold_uncertainty_score":0.00795424},"labels":[],"label_agreement":null},{"id":"W2518586256","doi":"10.1016/j.bmcl.2016.08.034","title":"Structure–activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Bioassay; Docking (animal); Stereochemistry; Enzyme inhibitor; Structure–activity relationship; Combinatorial chemistry; Cyclooxygenase; Enzyme; In vitro; Biochemistry","score_opus":0.028614546420571596,"score_gpt":0.26488965913601326,"score_spread":0.23627511271544166,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2518586256","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9742426,0.018310735,0.003930009,0.00026180386,0.000118958465,0.00013059699,0.000839251,0.00013559184,0.0020304502],"genre_scores_gemma":[0.9786951,0.012140846,0.00449949,0.000121150304,0.00003102404,0.00008424656,0.0012857078,0.000014918754,0.0031275523],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999163,0.000015917147,0.0000111495465,0.000013829425,0.000019886606,0.000022767774],"domain_scores_gemma":[0.999926,0.000011400843,0.000022413898,0.000006972606,0.000014898288,0.000018313938],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024862826,0.00047663605,0.0006214331,0.00034854776,0.00020998057,0.00026716804,0.00054003653,0.0002443001,0.0017044378],"category_scores_gemma":[0.00019455992,0.0002178803,0.00041947272,0.0003706245,0.00018838368,0.0002760926,0.00013902957,0.00050602516,0.0004071865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00079353683,0.00048431364,0.00043290923,0.00029326708,0.00006894801,0.00026428784,0.000055674896,0.0020706467,0.9839627,0.00035767403,0.00047049366,0.010745608],"study_design_scores_gemma":[0.0007268435,0.0133742895,0.005522759,0.00004213523,0.0005502312,0.0011542605,0.000059778507,0.0072033345,0.95948166,0.00013653481,0.011680285,0.00006780372],"about_ca_topic_score_codex":0.00079090195,"about_ca_topic_score_gemma":0.0030463226,"teacher_disagreement_score":0.0017044378,"about_ca_system_score_codex":0.00036829404,"about_ca_system_score_gemma":0.00032786236,"threshold_uncertainty_score":0.00570184},"labels":[],"label_agreement":null},{"id":"W2519688704","doi":"10.1016/j.bmcl.2016.09.046","title":"Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé","keywords":"Chemistry; Steroid; Cytochrome P450; CYP1B1; Stereochemistry; Heme; Pharmacology; IC50; Enzyme; Estrone; Active site; Docking (animal); CYP3A4; Structure–activity relationship; Biochemistry; In vitro","score_opus":0.04944998651031944,"score_gpt":0.35174573372370865,"score_spread":0.3022957472133892,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2519688704","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93254244,0.020863172,0.0237927,0.001646393,0.00031051735,0.00015053432,0.00041236478,0.0003839826,0.019897955],"genre_scores_gemma":[0.9868885,0.0049794405,0.0023680972,0.00015810698,0.000043770648,0.000020373012,0.00014134527,0.000021366173,0.0053790626],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990356,0.000031197313,0.0000044424874,0.000017700382,0.000019160336,0.000023920062],"domain_scores_gemma":[0.9999542,0.000010178318,0.000012476184,0.0000075168828,0.0000065587997,0.0000090019375],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016708269,0.00017577641,0.00019283826,0.00014107721,0.0001098264,0.0002200656,0.00012209901,0.00015681854,0.0022220078],"category_scores_gemma":[0.0002237133,0.000072739516,0.00018565186,0.00022547848,0.0001480975,0.00010274585,0.00013788861,0.00043726398,0.00055174297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011504159,0.00024331851,0.0025076966,0.00028787798,0.00008636223,0.00059620786,0.0001321644,0.0016418482,0.84443533,0.0037494963,0.0029602349,0.14220908],"study_design_scores_gemma":[0.00020353583,0.0029666978,0.0033797529,0.000020136948,0.00009501272,0.001873462,0.000054254357,0.0023036813,0.93667537,0.00058931956,0.051820405,0.000018401885],"about_ca_topic_score_codex":0.00053939555,"about_ca_topic_score_gemma":0.0012169019,"teacher_disagreement_score":0.0022220078,"about_ca_system_score_codex":0.00021058929,"about_ca_system_score_gemma":0.0001704622,"threshold_uncertainty_score":0.007433355},"labels":[],"label_agreement":null},{"id":"W2521539114","doi":"10.1016/j.bmcl.2016.09.054","title":"Design, synthesis and biological activity of novel molecules designed to target PARP and DNA","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Poly ADP ribose polymerase; Chemistry; Moiety; DNA; Chinese hamster ovary cell; DNA repair; DNA damage; Ribose; Biochemistry; Polymerase; Molecular biology; Combinatorial chemistry; Stereochemistry; Biology; Enzyme","score_opus":0.037115696313870954,"score_gpt":0.26791667852399653,"score_spread":0.23080098221012557,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2521539114","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97131854,0.0055339406,0.018535864,0.0002210414,0.00007228868,0.0004856576,0.00039463484,0.00014817363,0.0032898015],"genre_scores_gemma":[0.96111226,0.0044217,0.029436253,0.00014032083,0.000034169385,0.00035127613,0.0005383423,0.000026605156,0.0039390903],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999923,0.000012526223,0.0000097537395,0.000016596226,0.000018648361,0.000019466102],"domain_scores_gemma":[0.9999107,0.0000122229,0.000030068719,0.000008882653,0.000013968644,0.000024179195],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022375211,0.0003804171,0.00041224973,0.00023920836,0.00012753643,0.00033395083,0.0003495384,0.0003214485,0.0011368017],"category_scores_gemma":[0.00016157338,0.00020778323,0.0002197207,0.00021579298,0.0002241512,0.00027810837,0.00017728408,0.0005177524,0.0003350261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020986941,0.00019372244,0.0001799237,0.0002034289,0.000017129998,0.00012542971,0.000043383414,0.0014321649,0.98463607,0.0007911764,0.000089829104,0.012077808],"study_design_scores_gemma":[0.00021482809,0.0025490564,0.00063752756,0.000011110395,0.000044286433,0.00019976475,0.000013454467,0.0012122986,0.98740816,0.000103137485,0.0075922585,0.0000142205645],"about_ca_topic_score_codex":0.00017112534,"about_ca_topic_score_gemma":0.0003915064,"teacher_disagreement_score":0.0011368017,"about_ca_system_score_codex":0.00031656062,"about_ca_system_score_gemma":0.00026043016,"threshold_uncertainty_score":0.0038030148},"labels":[],"label_agreement":null},{"id":"W2551996920","doi":"10.1016/j.bmcl.2016.11.058","title":"Squarate-based carbocyclic nucleosides: Syntheses, computational analyses and anticancer/antiviral evaluation","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Waterloo","keywords":"Chemistry; Hydroxymethyl; Synthon; Squaric acid; Nucleobase; Stereochemistry; Amino acid; Pyrophosphate; Guanidine; Chemical synthesis; Combinatorial chemistry; Organic chemistry; Biochemistry; Enzyme","score_opus":0.047054108926549064,"score_gpt":0.31579796441802677,"score_spread":0.2687438554914777,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2551996920","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97269046,0.006775042,0.0070093,0.00014334552,0.00004831818,0.00012440115,0.0010074408,0.0003403409,0.01186136],"genre_scores_gemma":[0.98075944,0.004264262,0.01132395,0.00005594052,0.000016500544,0.0000884914,0.0012628573,0.000046919813,0.0021815973],"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999416,0.000012765677,0.000003931027,0.000012277063,0.000016052949,0.000013303047],"domain_scores_gemma":[0.99990726,0.00003763573,0.000015286736,0.000008236372,0.000017577246,0.000014100754],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028740268,0.00053926883,0.0006574907,0.000281046,0.00026075315,0.00049975794,0.00046057496,0.00029050547,0.004503512],"category_scores_gemma":[0.000371734,0.00013938066,0.0005027113,0.00034248029,0.0001471555,0.00046277622,0.00029625295,0.00046294852,0.0005285887],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0039504487,0.0015658883,0.0060730707,0.004169401,0.00062959915,0.0018684943,0.0002639662,0.46875942,0.32906318,0.024508003,0.0036995145,0.15544906],"study_design_scores_gemma":[0.0010897327,0.011799885,0.0027635405,0.00020948504,0.0010050943,0.00078796165,0.00032555862,0.59029233,0.35602883,0.0050139083,0.030528607,0.00015504961],"about_ca_topic_score_codex":0.0025650873,"about_ca_topic_score_gemma":0.0056113824,"teacher_disagreement_score":0.004503512,"about_ca_system_score_codex":0.00045885428,"about_ca_system_score_gemma":0.0006092954,"threshold_uncertainty_score":0.015065789},"labels":[],"label_agreement":null},{"id":"W2552721325","doi":"10.1016/j.bmcl.2016.11.052","title":"Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hôpital Saint-François d'Assise; Université Laval; PROTEO","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Sulfamide; Chemistry; Pyrimidine; In vitro; Stereochemistry; Bearing (navigation); Group (periodic table); Growth inhibition; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.012044601559754741,"score_gpt":0.21608945811517247,"score_spread":0.20404485655541774,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2552721325","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98250777,0.005007485,0.0059836153,0.00012973901,0.00008874337,0.00012700958,0.0005989181,0.00011415148,0.00544261],"genre_scores_gemma":[0.98949426,0.0026175913,0.004740736,0.000044793687,0.000022149754,0.00004573705,0.0004976592,0.000012260915,0.0025247887],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999323,0.000010255105,0.000009099568,0.000010115988,0.0000143262405,0.000023941906],"domain_scores_gemma":[0.9999399,0.000007922084,0.00001594411,0.0000074153004,0.000010970815,0.000017847207],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017126932,0.00037894864,0.00034040824,0.00018540192,0.00016836177,0.00014755946,0.00037718494,0.0002538423,0.0014607796],"category_scores_gemma":[0.00012920138,0.00013056447,0.00025074746,0.00023352004,0.0001588183,0.00022070188,0.00015273716,0.00030667288,0.00028998413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004565422,0.00016516841,0.0002453716,0.00031377553,0.000028417184,0.0006022695,0.000118638796,0.00137629,0.97651917,0.0009631791,0.00036115048,0.018850068],"study_design_scores_gemma":[0.00010312812,0.0034650825,0.0017966526,0.000016119895,0.000060814844,0.0005202831,0.000029539573,0.0011922912,0.981247,0.00011485424,0.011429262,0.000024866229],"about_ca_topic_score_codex":0.0007147153,"about_ca_topic_score_gemma":0.0012308512,"teacher_disagreement_score":0.0014607796,"about_ca_system_score_codex":0.00024489503,"about_ca_system_score_gemma":0.00030702772,"threshold_uncertainty_score":0.004886806},"labels":[],"label_agreement":null},{"id":"W2555544901","doi":"10.1016/j.bmcl.2016.11.066","title":"NMR strategies to support medicinal chemistry workflows for primary structure determination","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Axial and Atropisomeric Chirality Synthesis","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Chemistry; Characterization (materials science); Primary (astronomy); Drug discovery; Workflow; Combinatorial chemistry; Nanotechnology; Computer science; Database","score_opus":0.010065437593140604,"score_gpt":0.23075334565744218,"score_spread":0.22068790806430158,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2555544901","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.026477726,0.00077545247,0.9463087,0.0010890891,0.00021892361,0.00041628364,0.0015180393,0.0125362165,0.010659482],"genre_scores_gemma":[0.14460936,0.0012834887,0.84505725,0.0006936221,0.0001549216,0.00033229135,0.0025442503,0.0013673576,0.0039574523],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99895644,0.00022664621,0.00011092185,0.00022328673,0.0003420626,0.00014072542],"domain_scores_gemma":[0.996899,0.00096512464,0.00024368636,0.00071691547,0.00093690044,0.00023830192],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0032634635,0.0012505376,0.00061397406,0.0012822571,0.00088878674,0.002313917,0.0013332367,0.0008743015,0.0065643894],"category_scores_gemma":[0.0059826123,0.0007022654,0.00059324346,0.0007706364,0.0007042318,0.002284435,0.0016133923,0.0017826656,0.0050264243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00062347576,0.00018414852,0.00067291345,0.00043778567,0.000055616285,0.00051522104,0.0003510836,0.0035325745,0.8220818,0.023204524,0.008246686,0.14009419],"study_design_scores_gemma":[0.000064969834,0.00015334312,0.00034232205,0.000057004407,0.00005614836,0.0005299652,0.00015486627,0.026491998,0.91473395,0.014078256,0.043261908,0.00007518355],"about_ca_topic_score_codex":0.0012379793,"about_ca_topic_score_gemma":0.0020255742,"teacher_disagreement_score":0.0065643894,"about_ca_system_score_codex":0.0007395011,"about_ca_system_score_gemma":0.0023165594,"threshold_uncertainty_score":0.02196002},"labels":[],"label_agreement":null},{"id":"W2559627334","doi":"10.1016/j.bmcl.2016.11.087","title":"Ser422 phosphorylation blocks human Tau cleavage by caspase-3: Biochemical implications to Alzheimer’s Disease","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Canada; Ottawa Hospital; Health Sciences Centre","funders":"University of Ottawa","keywords":"Cleavage (geology); Phosphorylation; Chemistry; Caspase 3; Biochemistry; Biology; Apoptosis; Programmed cell death","score_opus":0.022906312301303,"score_gpt":0.2974536943182118,"score_spread":0.27454738201690876,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2559627334","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.995272,0.0012459457,0.0007099621,0.00019200654,0.00008918862,0.000029562687,0.00021030879,0.000050028324,0.0022009579],"genre_scores_gemma":[0.9960162,0.00080591405,0.00056949473,0.00008539793,0.000025583271,0.000028880562,0.00051818305,0.000027204642,0.0019231274],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982786,0.0000402706,0.000026298112,0.000023888457,0.000026665082,0.000054862998],"domain_scores_gemma":[0.9998945,0.000027815782,0.000016756954,0.000019072655,0.0000100053285,0.000031810334],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031447964,0.0005699125,0.00034347188,0.00022877438,0.00031333283,0.00039343172,0.00033117126,0.00038434245,0.0041183676],"category_scores_gemma":[0.00030358552,0.00024428172,0.0002982964,0.00021687217,0.00029863816,0.00036468255,0.00020744055,0.00077466463,0.0006551273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0055330424,0.0006104472,0.00027494234,0.00009201479,0.00003677404,0.00029612682,0.000050861505,0.00020910926,0.9884249,0.00041263504,0.0003023498,0.0037568465],"study_design_scores_gemma":[0.0006069025,0.0019876703,0.0019224223,0.000010434768,0.000045999717,0.00064174406,0.000037650978,0.00095410715,0.9912214,0.0002538494,0.0023082492,0.000009587425],"about_ca_topic_score_codex":0.0005997287,"about_ca_topic_score_gemma":0.00061014615,"teacher_disagreement_score":0.0041183676,"about_ca_system_score_codex":0.00030114417,"about_ca_system_score_gemma":0.00037592388,"threshold_uncertainty_score":0.013777256},"labels":[],"label_agreement":null},{"id":"W2564949433","doi":"10.1016/j.bmcl.2016.12.052","title":"BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Luminescence and Fluorescent Materials","field":"Materials Science","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"BODIPY; Chemistry; Sonogashira coupling; Conjugate; In vivo; Ligand (biochemistry); Estrogen receptor; Fluorescence; Moiety; Stereochemistry; Fluorescence-lifetime imaging microscopy; Biophysics; Receptor; Biochemistry; Breast cancer; Cancer; Internal medicine; Medicine","score_opus":0.024150867159497415,"score_gpt":0.20206840828037526,"score_spread":0.17791754112087785,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2564949433","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9853409,0.0034846368,0.0059490534,0.00024089482,0.000037320253,0.000058172205,0.00064131076,0.00010190173,0.0041457894],"genre_scores_gemma":[0.98858976,0.0016569999,0.0024181027,0.00006925242,0.000009248655,0.00004079484,0.0006138658,0.000028951747,0.006573025],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998809,0.000023094331,0.0000087578655,0.000029723587,0.000018324103,0.000039237417],"domain_scores_gemma":[0.99991,0.000026446149,0.000023529567,0.000012056425,0.000011134579,0.000016951606],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025638577,0.00025839292,0.00019469002,0.00012966062,0.00017897642,0.00021624469,0.0002474956,0.0002357664,0.0020041896],"category_scores_gemma":[0.00023055311,0.00017470168,0.00010825583,0.0002207044,0.00018639826,0.00028882473,0.00010876865,0.00027047738,0.00053475634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005670852,0.000042277086,0.00037363145,0.000044344386,0.000008529515,0.00010392176,0.00003144449,0.00046268813,0.99289095,0.00033766928,0.00016684897,0.0049706013],"study_design_scores_gemma":[0.000024825997,0.00025421262,0.0011518075,0.0000022665622,0.000011642649,0.0001411945,0.000011046106,0.00031917656,0.99486107,0.000027347223,0.0031907507,0.000004699119],"about_ca_topic_score_codex":0.001015464,"about_ca_topic_score_gemma":0.0015637304,"teacher_disagreement_score":0.0020041896,"about_ca_system_score_codex":0.000579612,"about_ca_system_score_gemma":0.00026410058,"threshold_uncertainty_score":0.0067046285},"labels":[],"label_agreement":null},{"id":"W2574397017","doi":"10.1016/j.bmcl.2017.01.060","title":"Klyflaccisteroids K–M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Cytotoxicity; Coral; Elastase; Superoxide; Stereochemistry; Biological activity; Biochemistry; In vitro; Enzyme","score_opus":0.011858880318566524,"score_gpt":0.24885111019788503,"score_spread":0.2369922298793185,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2574397017","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98666745,0.003809076,0.001816131,0.0002568886,0.000047204034,0.000043843138,0.000751947,0.00006576019,0.0065416857],"genre_scores_gemma":[0.99333596,0.0013646773,0.0010191279,0.00007933789,0.000012666286,0.000011101204,0.00049459003,0.000009375104,0.0036731719],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995995,0.0000044365597,0.0000041012504,0.0000067478713,0.000007580218,0.000017231672],"domain_scores_gemma":[0.9999478,0.000006278724,0.000013423894,0.000007197501,0.000006079718,0.000019182995],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000078372614,0.00039276094,0.00011146204,0.00024164739,0.00019939481,0.0001529692,0.0001621823,0.00017896072,0.0019052585],"category_scores_gemma":[0.00010925419,0.00006265807,0.00018577298,0.00021940754,0.00025507962,0.00024148617,0.00030402173,0.00027574747,0.00032076245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043144636,0.000014962316,0.00059999875,0.00014396083,0.000010793028,0.0005511362,0.00009560501,0.00023121382,0.98667055,0.00032318584,0.00015906407,0.01076804],"study_design_scores_gemma":[0.000043779823,0.00077950355,0.012126968,0.000027893406,0.000044862634,0.00062027836,0.00012570462,0.00021812538,0.97317284,0.00017865346,0.012636819,0.00002450655],"about_ca_topic_score_codex":0.0015717683,"about_ca_topic_score_gemma":0.0024721576,"teacher_disagreement_score":0.0019052585,"about_ca_system_score_codex":0.0001775942,"about_ca_system_score_gemma":0.00032969037,"threshold_uncertainty_score":0.006373763},"labels":[],"label_agreement":null},{"id":"W2574869250","doi":"10.1016/j.bmcl.2017.01.052","title":"Design, synthesis and evaluation of novel bifunctional tetrahydroxamate chelators for PET imaging of 89Zr-labeled antibodies","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Terry Fox Research Institute","keywords":"Chemistry; Bifunctional; Pet imaging; Chemical synthesis; Antibody; Chelation; Combinatorial chemistry; Stereochemistry; Positron emission tomography; Biochemistry; In vitro; Nuclear medicine; Organic chemistry; Catalysis","score_opus":0.07057765214206149,"score_gpt":0.34590110834027354,"score_spread":0.2753234561982121,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2574869250","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9585171,0.0041601923,0.03399604,0.00025557162,0.000050188195,0.00031640547,0.00024092218,0.00022780466,0.0022357896],"genre_scores_gemma":[0.9603552,0.0016863141,0.03431247,0.00014971971,0.00002229087,0.00014315554,0.00050354167,0.00006489974,0.0027623377],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99982303,0.00003608102,0.000018504494,0.00003856359,0.00004044769,0.000043517117],"domain_scores_gemma":[0.99986374,0.000017305601,0.00004747791,0.000014286158,0.000032049025,0.000025136962],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00051153015,0.00034983092,0.0003683058,0.00019241693,0.00020817826,0.00042310986,0.00048168833,0.0004639244,0.00053099723],"category_scores_gemma":[0.00029383413,0.00023149078,0.00020525903,0.00014466967,0.00021896283,0.0003056565,0.00024851,0.00031254816,0.00036413208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012570205,0.00003655045,0.000112112306,0.00008337329,0.0000094694,0.000041186468,0.000027443219,0.00033318004,0.994739,0.00025281022,0.00009003761,0.0041491524],"study_design_scores_gemma":[0.00004342959,0.00035090453,0.00028997535,0.0000047320405,0.000018695766,0.00011900577,0.000010396942,0.0012583811,0.99414,0.000025355483,0.003732094,0.000007041078],"about_ca_topic_score_codex":0.0004709804,"about_ca_topic_score_gemma":0.0011110404,"teacher_disagreement_score":0.0005365226,"about_ca_system_score_codex":0.0005365226,"about_ca_system_score_gemma":0.00029042407,"threshold_uncertainty_score":0.0038927197},"labels":[],"label_agreement":null},{"id":"W2586230787","doi":"10.1016/j.bmcl.2017.02.007","title":"Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Streptomyces; Tripeptide; Moiety; Stereochemistry; Thiostrepton; In vitro; Streptomycetaceae; Cathepsin D; Biochemistry; Pepstatin; Cathepsin L; Cathepsin; Actinomycetales; Molecular biology; Enzyme; Peptide; Gene; Protease; Biology","score_opus":0.010735152655959703,"score_gpt":0.24008810213004683,"score_spread":0.22935294947408713,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2586230787","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9932352,0.0016044774,0.0032038146,0.000075685086,0.000029892426,0.000024315861,0.00024500486,0.000046470104,0.0015351538],"genre_scores_gemma":[0.99624383,0.0006799823,0.0014623757,0.000026830057,0.000008374404,0.0000069494213,0.00028741153,0.000009706404,0.0012744289],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999454,0.000012222029,0.0000057702837,0.000009720008,0.000014695179,0.000012293244],"domain_scores_gemma":[0.9999466,0.000012518972,0.000016080612,0.0000054429715,0.000004805779,0.0000146198945],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006113616,0.0002831063,0.00016932079,0.000106366075,0.00006440338,0.0001689705,0.0001107033,0.00018439525,0.0007160689],"category_scores_gemma":[0.00009683742,0.00008048259,0.00012855289,0.000085225816,0.00013328547,0.00012966743,0.00012649194,0.00032249614,0.0002992569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009811062,0.000006849385,0.00006318871,0.000016342072,0.0000025978893,0.000053010815,0.0000029176392,0.000049748924,0.99874866,0.000014917392,0.000011308461,0.00093238463],"study_design_scores_gemma":[0.000018538445,0.0003113677,0.00102649,0.0000022086563,0.000008261788,0.00036933753,0.000007456284,0.00021753767,0.99705887,0.000015707257,0.0009616092,0.0000026747307],"about_ca_topic_score_codex":0.00020665073,"about_ca_topic_score_gemma":0.0002978338,"teacher_disagreement_score":0.0007160689,"about_ca_system_score_codex":0.00010209559,"about_ca_system_score_gemma":0.000116548006,"threshold_uncertainty_score":0.002395451},"labels":[],"label_agreement":null},{"id":"W2586513881","doi":"10.1016/j.bmcl.2017.02.016","title":"6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Cytotoxicity; Stereochemistry; Cytotoxic T cell; Aryl; L1210 cells; Chemical synthesis; In vitro; IC50; Structure–activity relationship; Pharmacology; Biochemistry","score_opus":0.014420319597354084,"score_gpt":0.2555667988334556,"score_spread":0.24114647923610155,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2586513881","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94509125,0.006757135,0.011693936,0.00069294946,0.00025857505,0.00017749703,0.0012108603,0.000803304,0.033314552],"genre_scores_gemma":[0.9788031,0.003230604,0.004057155,0.00015382291,0.000041599913,0.00014675365,0.0007481143,0.00003611276,0.012782687],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999056,0.00001267216,0.0000039473357,0.000021418446,0.000016519463,0.00003977402],"domain_scores_gemma":[0.99995375,0.0000035648848,0.0000085535,0.0000066122866,0.0000063151715,0.00002120578],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008760143,0.00027256593,0.00029340698,0.00023294277,0.00023708533,0.0003075759,0.00034389782,0.00019145467,0.0034317104],"category_scores_gemma":[0.000073341376,0.00010036139,0.0001067239,0.0002457701,0.0002185659,0.00026354217,0.00037771423,0.0004006338,0.0012436623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007936667,0.00015254029,0.00047274813,0.00021910839,0.000013076841,0.00038406852,0.00016576704,0.0011250427,0.95533246,0.0057320376,0.0019463609,0.03366313],"study_design_scores_gemma":[0.00021486785,0.0024246678,0.004200066,0.00003177772,0.000028988465,0.0007659731,0.000109126966,0.0015741559,0.92172277,0.0006291053,0.0682659,0.000032551296],"about_ca_topic_score_codex":0.0006608193,"about_ca_topic_score_gemma":0.0010239055,"teacher_disagreement_score":0.0034317104,"about_ca_system_score_codex":0.00051231164,"about_ca_system_score_gemma":0.00041759652,"threshold_uncertainty_score":0.011480212},"labels":[],"label_agreement":null},{"id":"W2589977260","doi":"10.1016/j.bmcl.2017.02.042","title":"Biologically active perspective synthesis of heteroannulated 8-nitroquinolines with green chemistry approach","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Winnipeg","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Quinoline; Cytotoxicity; Antioxidant; Antibacterial activity; Biological activity; Stereochemistry; Cell culture; Docking (animal); Apoptosis; Chemical synthesis; Combinatorial chemistry; Biochemistry; In vitro; Bacteria; Organic chemistry","score_opus":0.018886489579583894,"score_gpt":0.23139057506804767,"score_spread":0.21250408548846378,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2589977260","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.771146,0.025474098,0.13201198,0.0012063589,0.00067772943,0.00036141157,0.00074261293,0.0006175076,0.06776229],"genre_scores_gemma":[0.9543381,0.007241833,0.026877092,0.00037012203,0.000074462674,0.00011956182,0.00031579542,0.00004602368,0.010616929],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999136,0.000015336653,0.0000048320176,0.000020750214,0.000016422977,0.00002896074],"domain_scores_gemma":[0.9999726,0.0000043670793,0.000006565898,0.0000036921874,0.000006684591,0.0000061561846],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022979923,0.00038475523,0.0002583998,0.00018475004,0.00021442273,0.00020853784,0.0006875883,0.00041306167,0.0025182073],"category_scores_gemma":[0.00008321656,0.00012847655,0.00030392405,0.00012035915,0.00024779452,0.0003810219,0.00037614183,0.0005360625,0.0007207068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014519978,0.00009947813,0.00012773354,0.00047854762,0.000024583449,0.00073732843,0.00019022389,0.00151853,0.9602432,0.015889648,0.00070805807,0.019837463],"study_design_scores_gemma":[0.00007997453,0.0019639295,0.0006816746,0.000057648067,0.00004927121,0.0011102327,0.000076392396,0.002280982,0.9263621,0.0045407824,0.06273847,0.000058681104],"about_ca_topic_score_codex":0.00037682557,"about_ca_topic_score_gemma":0.00082181056,"teacher_disagreement_score":0.0025182073,"about_ca_system_score_codex":0.00031659534,"about_ca_system_score_gemma":0.00027271514,"threshold_uncertainty_score":0.0084242225},"labels":[],"label_agreement":null},{"id":"W2591014544","doi":"10.1016/j.bmcl.2017.02.039","title":"Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Shionogi","keywords":"Raltegravir; Aminal; Integrase; Chemistry; Pharmacology; Integrase inhibitor; Pharmacokinetics; Human immunodeficiency virus (HIV); Virology; Stereochemistry; Medicine; Biochemistry; Antiretroviral therapy; Viral load","score_opus":0.014728017510283953,"score_gpt":0.24677313280944854,"score_spread":0.23204511529916458,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2591014544","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9596239,0.020479212,0.008350902,0.0004155361,0.00011554161,0.00037661547,0.0005617886,0.0001495137,0.009926902],"genre_scores_gemma":[0.9802689,0.009409678,0.0055614654,0.00018571955,0.00002503513,0.00007236849,0.00049280614,0.000019014398,0.0039651296],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988174,0.0000247796,0.000008406267,0.000016722897,0.00003577445,0.00003250793],"domain_scores_gemma":[0.99995697,0.000007698303,0.000012921602,0.0000030064245,0.000008824809,0.000010671373],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003191491,0.00047094448,0.00037549174,0.00030894598,0.00017650278,0.00048150096,0.00038782237,0.00030372766,0.0018148887],"category_scores_gemma":[0.00018983522,0.00022010945,0.0002746188,0.00022015438,0.0001587995,0.00027441935,0.00024630118,0.0005997662,0.00033788936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013259161,0.00095604867,0.0007147742,0.00047566844,0.000079743804,0.000755298,0.00013240655,0.007372305,0.90629387,0.0019836216,0.00090161734,0.07900866],"study_design_scores_gemma":[0.001321609,0.010677697,0.0034349074,0.00011566552,0.00018531269,0.0014888016,0.000098709854,0.012093643,0.9370196,0.00047015594,0.033026606,0.00006722375],"about_ca_topic_score_codex":0.00045508877,"about_ca_topic_score_gemma":0.0019648287,"teacher_disagreement_score":0.0018148887,"about_ca_system_score_codex":0.00029039278,"about_ca_system_score_gemma":0.00031079445,"threshold_uncertainty_score":0.0060714483},"labels":[],"label_agreement":null},{"id":"W2598823287","doi":"10.1016/j.bmcl.2017.03.078","title":"Synthesis and evaluation of 18F-labeled CJ-042794 for imaging prostanoid EP4 receptor expression in cancer with positron emission tomography","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Prostate Cancer Canada","keywords":"Chemistry; Positron emission tomography; Prostanoid; Biodistribution; Receptor; Radiosynthesis; Nuclear medicine; LNCaP; Cancer cell; Cancer; Internal medicine; In vitro; Biochemistry; Medicine","score_opus":0.013590193097322801,"score_gpt":0.28405591655299955,"score_spread":0.27046572345567677,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2598823287","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.89853984,0.008949086,0.06750379,0.00072785985,0.00018861565,0.0013831664,0.003093751,0.0004587959,0.019155141],"genre_scores_gemma":[0.94786394,0.0043573007,0.033345964,0.0002462171,0.000038812534,0.0003496555,0.0033286668,0.00021563271,0.010253866],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99976057,0.000055535726,0.000014793301,0.0000420791,0.000049180064,0.00007785028],"domain_scores_gemma":[0.9998361,0.000026755706,0.000030099409,0.00003141548,0.000038412574,0.000037206748],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005858182,0.00059489114,0.00052183616,0.0006060448,0.0004675575,0.00041681007,0.0015440652,0.0007827209,0.0021323843],"category_scores_gemma":[0.00043954616,0.00042295898,0.00045958534,0.00060772046,0.00032227425,0.0004065082,0.0003260728,0.0006457566,0.0010357472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013103836,0.00052939483,0.0003822937,0.00040023596,0.00013103778,0.0010771307,0.0001800945,0.004444361,0.95824707,0.0017544086,0.0012965407,0.030247135],"study_design_scores_gemma":[0.00016830752,0.0011686346,0.00059983606,0.000015315158,0.00009619579,0.00057063,0.00002550367,0.0017447894,0.98370683,0.00011076599,0.011755757,0.000037560003],"about_ca_topic_score_codex":0.0029354151,"about_ca_topic_score_gemma":0.0023996935,"teacher_disagreement_score":0.0029354151,"about_ca_system_score_codex":0.00077895325,"about_ca_system_score_gemma":0.00096501777,"threshold_uncertainty_score":0.0071335435},"labels":[],"label_agreement":null},{"id":"W2604825742","doi":"10.1016/j.bmcl.2017.04.006","title":"Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Tacrine; Chemistry; CYP1A2; Pharmacology; Cytochrome P450; Stereochemistry; CYP3A4; Cholinesterase; Biochemistry; Enzyme; Acetylcholinesterase; Biology","score_opus":0.06475551497196065,"score_gpt":0.3352580173501522,"score_spread":0.27050250237819157,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2604825742","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99857986,0.00039337127,0.00060993014,0.000014612002,0.0000019247539,0.0000076092465,0.0000783487,0.00000898996,0.00030538268],"genre_scores_gemma":[0.9992065,0.000148714,0.0003201173,0.000008903212,0.0000017649681,0.000003565905,0.00007023003,0.0000017456738,0.00023841382],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998859,0.000046953483,0.0000068827026,0.000021170597,0.000022768343,0.00001627259],"domain_scores_gemma":[0.99981624,0.000058481044,0.00004105092,0.00001848458,0.000039308696,0.00002652171],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025908338,0.00022989853,0.00022703255,0.0002843932,0.00019636436,0.00017444318,0.00017613394,0.00036671082,0.0011039181],"category_scores_gemma":[0.00051931775,0.00015004858,0.0002665203,0.0002239916,0.00013087445,0.00012616513,0.000105520994,0.0002777218,0.0001615854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0036672887,0.00029852617,0.022561772,0.000074895135,0.00018087197,0.00035334207,0.00009798144,0.0023307572,0.9601323,0.0001079384,0.00013041728,0.01006396],"study_design_scores_gemma":[0.0001536776,0.008037495,0.089735724,0.000012939957,0.0005107323,0.0024800722,0.00013788477,0.023267364,0.8741569,0.00013848425,0.0013220807,0.00004663352],"about_ca_topic_score_codex":0.0022071472,"about_ca_topic_score_gemma":0.0024409276,"teacher_disagreement_score":0.0022071472,"about_ca_system_score_codex":0.0002292987,"about_ca_system_score_gemma":0.0001113248,"threshold_uncertainty_score":0.0043886304},"labels":[],"label_agreement":null},{"id":"W2605311545","doi":"10.1016/j.bmcl.2017.03.084","title":"Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective","year":2017,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":26,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Allosteric regulation; Chemistry; Drug discovery; Computational biology; Terminology; Biochemical engineering; Drug development; Drug; Pharmacology; Biochemistry; Receptor; Medicine; Biology","score_opus":0.12275411776816658,"score_gpt":0.4060510915619075,"score_spread":0.2832969737937409,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2605311545","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0009568147,0.97177404,0.015779404,0.0026656317,0.00033664142,0.000034532357,0.000095090814,0.0001112646,0.00824663],"genre_scores_gemma":[0.008963255,0.9770174,0.0104790265,0.00091052946,0.00038171597,0.000049207832,0.00009842228,0.00002571787,0.0020747364],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99967635,0.000079612546,0.000030495203,0.000056221543,0.00012823737,0.000029064086],"domain_scores_gemma":[0.9994529,0.00036501497,0.00005250857,0.000029980178,0.000074689975,0.000024857141],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012181498,0.0009744425,0.0015186707,0.0016873667,0.00027409327,0.0016845905,0.0015017656,0.0013532734,0.004232118],"category_scores_gemma":[0.0016298665,0.0004548025,0.00085782626,0.00198988,0.0011230498,0.0025919543,0.00090612704,0.0036212981,0.0033409265],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007686898,0.00020325533,0.0002795915,0.011123335,0.00012099233,0.00028884938,0.00010205798,0.0091871815,0.007703546,0.119258665,0.022027357,0.82962835],"study_design_scores_gemma":[0.00004484526,0.00032393113,0.0003212456,0.002856509,0.00009717638,0.0014925281,0.00008462838,0.0072428863,0.005951228,0.054515872,0.92699134,0.00007776461],"about_ca_topic_score_codex":0.00045285063,"about_ca_topic_score_gemma":0.00061674847,"teacher_disagreement_score":0.004232118,"about_ca_system_score_codex":0.00090354064,"about_ca_system_score_gemma":0.0008083185,"threshold_uncertainty_score":0.014157832},"labels":[],"label_agreement":null},{"id":"W2606483628","doi":"10.1016/j.bmcl.2017.04.064","title":"Design and synthesis of a fluorinated quinazoline-based type-II Trk inhibitor as a scaffold for PET radiotracer development","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Cancer Research Society","keywords":"Chemistry; Scaffold; Quinazoline; Trk receptor; Radiosynthesis; Chemical synthesis; Combinatorial chemistry; Stereochemistry; In vitro; Biochemistry; Receptor; Positron emission tomography; Biomedical engineering; Neuroscience","score_opus":0.019138494958294543,"score_gpt":0.29709861881089605,"score_spread":0.2779601238526015,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2606483628","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7838837,0.011253904,0.18291336,0.0010674575,0.00022564878,0.000997831,0.0016594451,0.0009144221,0.017084207],"genre_scores_gemma":[0.9569384,0.0031130675,0.03345341,0.00012480577,0.000019835055,0.00011517982,0.0007349078,0.000047080346,0.0054533016],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998894,0.000015510908,0.000007379315,0.000027828773,0.000022010194,0.000037840055],"domain_scores_gemma":[0.9999229,0.000008394155,0.000021478832,0.0000089801515,0.00001687606,0.000021325266],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027491665,0.00045697036,0.00036047766,0.00021551398,0.00023655043,0.0004239589,0.0007706533,0.00046171897,0.0018243601],"category_scores_gemma":[0.00017838829,0.00022866928,0.00030891065,0.00021691808,0.00021900164,0.00039341577,0.00024367226,0.00051195186,0.0007587022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002231722,0.00009748686,0.00017499054,0.0002293861,0.000022666904,0.0004516805,0.00010045623,0.0041134944,0.9784604,0.00227284,0.0005004554,0.013353109],"study_design_scores_gemma":[0.00011411788,0.0015552695,0.0005622165,0.000021517519,0.00005261092,0.00068992295,0.000036946578,0.0048445947,0.96824104,0.00028341715,0.023552915,0.000045326986],"about_ca_topic_score_codex":0.0008282227,"about_ca_topic_score_gemma":0.0014338066,"teacher_disagreement_score":0.0018243601,"about_ca_system_score_codex":0.0005637138,"about_ca_system_score_gemma":0.0005596456,"threshold_uncertainty_score":0.006103039},"labels":[],"label_agreement":null},{"id":"W2617747149","doi":"10.1016/j.bmcl.2017.05.080","title":"Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Hewitt Foundation; Biological and Environmental Research; National Institute of Diabetes and Digestive and Kidney Diseases; Skaggs Institute for Chemical Biology, Scripps Research Institute; National Center for Research Resources; Lita Annenberg Hazen Foundation; National Institute of General Medical Sciences; School of Medicine, Indiana University; National Institutes of Health","keywords":"Transthyretin; Chemistry; Tetramer; Small molecule; Docking (animal); Amyloidosis; In silico; Computational biology; Biochemistry; Pharmacology; Enzyme; Internal medicine; Medicine","score_opus":0.030905855873211197,"score_gpt":0.2923525737210733,"score_spread":0.2614467178478621,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2617747149","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.14299984,0.002073489,0.8377019,0.001065059,0.00012021688,0.00022840299,0.0020754505,0.0006041438,0.0131314825],"genre_scores_gemma":[0.92040247,0.0016403259,0.06529098,0.0002069535,0.000051088908,0.000663439,0.0013246444,0.00009161436,0.010328435],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9997149,0.00008923885,0.000014980405,0.00005881595,0.00007215971,0.000049944683],"domain_scores_gemma":[0.999273,0.0004678471,0.00010725377,0.00004590922,0.00007360731,0.00003247231],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00083088863,0.0007498876,0.000933059,0.00041569385,0.00018811715,0.0010102084,0.0010934215,0.00078787655,0.002348766],"category_scores_gemma":[0.0016515228,0.0003156201,0.00079071923,0.0003886629,0.00065923284,0.0009891745,0.0006277024,0.0010390823,0.0005360314],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030693124,0.0001613878,0.00065436313,0.0003273682,0.00009440052,0.00012526629,0.000058289137,0.8355716,0.049202435,0.0946918,0.0014143351,0.017391875],"study_design_scores_gemma":[0.0000282002,0.0001037521,0.00013987225,0.000005760854,0.000022015984,0.00003462335,0.000011345032,0.9765609,0.005693779,0.016121568,0.00126359,0.000014562837],"about_ca_topic_score_codex":0.0021347732,"about_ca_topic_score_gemma":0.0019378572,"teacher_disagreement_score":0.002348766,"about_ca_system_score_codex":0.0011246717,"about_ca_system_score_gemma":0.0007510058,"threshold_uncertainty_score":0.008160055},"labels":[],"label_agreement":null},{"id":"W2619708749","doi":"10.1016/j.bmcl.2017.05.086","title":"A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Glycomics Network; Austrian Science Fund","keywords":"Chemistry; Gangliosidosis; Lysosomal storage disease; Hydroxymethyl; Chaperone (clinical); Biochemistry; Enzyme; Stereochemistry","score_opus":0.05077207427793002,"score_gpt":0.3521340037549983,"score_spread":0.3013619294770683,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2619708749","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97588456,0.0080605885,0.010500834,0.00036659974,0.00019205356,0.00013602749,0.0006293916,0.000513889,0.0037160623],"genre_scores_gemma":[0.9838397,0.0043781283,0.0068071084,0.00019324022,0.0000450676,0.000076455515,0.00080892973,0.00004291744,0.0038085168],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995625,0.000007750172,0.0000035107967,0.000009326727,0.000009339332,0.000013925944],"domain_scores_gemma":[0.9999548,0.0000049476303,0.000012093953,0.0000066204148,0.000005733104,0.000015861917],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007913291,0.0002759421,0.00031866843,0.00015045718,0.00012141795,0.0002697002,0.00026467556,0.00020218322,0.00062762847],"category_scores_gemma":[0.00007838219,0.00008741076,0.00018040072,0.00017075926,0.00017051976,0.00025926254,0.00018035548,0.0004755272,0.00036224507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002485593,0.000037717542,0.00008832524,0.0000618896,0.000008355335,0.00014727522,0.000023000992,0.00020052382,0.9921787,0.00046083197,0.000213726,0.006331067],"study_design_scores_gemma":[0.000053655313,0.0005245464,0.00077406847,0.000006815395,0.000023976283,0.0005837581,0.000020353144,0.0005805015,0.9825058,0.000081403734,0.014831956,0.000013063283],"about_ca_topic_score_codex":0.00032907928,"about_ca_topic_score_gemma":0.0005906364,"teacher_disagreement_score":0.00062762847,"about_ca_system_score_codex":0.0002781683,"about_ca_system_score_gemma":0.00020568336,"threshold_uncertainty_score":0.0020996332},"labels":[],"label_agreement":null},{"id":"W2621171810","doi":"10.1016/j.bmcl.2017.05.088","title":"Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institut National de la Recherche Scientifique; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Peptide; Urotensin-II; Linker; Triazole; Dipeptide; Azide; Cyclic peptide; Peptide synthesis; Stereochemistry; Agonist; Tripeptide; Alkyne; Cycloaddition; Combinatorial chemistry; Residue (chemistry); Receptor; Biochemistry; Organic chemistry","score_opus":0.07679705194391749,"score_gpt":0.2927417242667708,"score_spread":0.2159446723228533,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2621171810","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99844056,0.0003197649,0.0004634877,0.00001962346,0.000029535127,0.000014430502,0.000026215628,0.000010860217,0.00067552767],"genre_scores_gemma":[0.9985644,0.00023454324,0.00041637465,0.000035142602,0.000005775888,0.000009927431,0.00006305167,0.000004948503,0.0006656685],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999409,0.000010155223,0.0000059850654,0.000011432904,0.000012086867,0.000019591773],"domain_scores_gemma":[0.9999285,0.000013978648,0.000018757712,0.0000074591544,0.000007414834,0.000023939074],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009690108,0.00020976705,0.00017334535,0.000058679387,0.00007624274,0.00017541477,0.00012613146,0.00022110628,0.0013663443],"category_scores_gemma":[0.00019346444,0.00009451559,0.00013015847,0.00006184327,0.00013831843,0.00017304132,0.00014711355,0.00031535962,0.00019429706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043523745,0.000036107893,0.00006966505,0.000020156802,0.00000669257,0.000053590953,0.000011171865,0.00011946468,0.9984059,0.00008304921,0.000020182537,0.00073884137],"study_design_scores_gemma":[0.000060112274,0.00092509174,0.0010894113,0.0000043087643,0.000018520574,0.00010783485,0.000015646283,0.0008341343,0.99618596,0.00004091478,0.0007129957,0.0000051536267],"about_ca_topic_score_codex":0.00019242903,"about_ca_topic_score_gemma":0.00024633686,"teacher_disagreement_score":0.0013663443,"about_ca_system_score_codex":0.00011835132,"about_ca_system_score_gemma":0.00010099704,"threshold_uncertainty_score":0.0045709014},"labels":[],"label_agreement":null},{"id":"W2621989225","doi":"10.1016/j.bmcl.2017.06.029","title":"Bioactive new withanolides from the cultured soft coral Sinularia brassica","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phytochemicals and Medicinal Plants","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Ministry of Science and Technology, Israel; Kaohsiung Medical University; Ministry of Science and Technology, Taiwan; National Sun Yat-sen University","keywords":"Chemistry; Cytochalasin; Coral; Elastase; Superoxide; Brassica; Stereochemistry; Cell culture; Cytochalasin B; Biochemistry; In vitro; Enzyme; Cell; Botany","score_opus":0.022576849422589744,"score_gpt":0.2678371845661557,"score_spread":0.24526033514356593,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2621989225","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95631665,0.016620865,0.003563067,0.00045453216,0.00020660296,0.000109000415,0.0024230806,0.00017709378,0.020129232],"genre_scores_gemma":[0.98151565,0.0062091486,0.0017405477,0.00022436044,0.00007564785,0.00003169457,0.0015391322,0.00004228424,0.008621457],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995446,0.000007781069,0.000004223198,0.000010558252,0.0000110085375,0.00001207224],"domain_scores_gemma":[0.9999385,0.0000108284985,0.000011386241,0.0000065884556,0.00001416157,0.000018419825],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007880999,0.0009927985,0.0003545462,0.00078767876,0.00038006203,0.00039439605,0.00013644621,0.00026180188,0.003264368],"category_scores_gemma":[0.00013161973,0.00013284266,0.0003475356,0.00038671872,0.00028472173,0.00033152066,0.00043123012,0.0004986865,0.0004999874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002828274,0.000018611021,0.00033379567,0.00025967316,0.000020214138,0.00047287584,0.000058614172,0.00014786137,0.9906064,0.00011785659,0.00012198523,0.0075593027],"study_design_scores_gemma":[0.0001747954,0.0015492381,0.022554409,0.00014752329,0.00035875727,0.0013385761,0.0006305634,0.00045988508,0.93670887,0.00071352604,0.03530785,0.000056017238],"about_ca_topic_score_codex":0.0010814401,"about_ca_topic_score_gemma":0.002556953,"teacher_disagreement_score":0.003264368,"about_ca_system_score_codex":0.00015312023,"about_ca_system_score_gemma":0.00031469407,"threshold_uncertainty_score":0.010920405},"labels":[],"label_agreement":null},{"id":"W2659349691","doi":"10.1016/j.bmcl.2017.06.048","title":"Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Chemistry; Oxime; Conjugate; In vitro; Coumarin; In vivo; Stereochemistry; Cytotoxicity; Biological activity; Biochemistry; Combinatorial chemistry; Pharmacology; Organic chemistry","score_opus":0.03694442080015405,"score_gpt":0.3009156407257928,"score_spread":0.26397121992563877,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2659349691","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98744977,0.004775069,0.0028560718,0.00012688345,0.00004628736,0.0001215164,0.0003032493,0.000042709147,0.004278565],"genre_scores_gemma":[0.9895754,0.004242209,0.00236869,0.000046123652,0.000018092485,0.000054141565,0.00035474435,0.0000059625654,0.0033347257],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999645,0.000007879389,0.0000040243563,0.000004563425,0.000007502064,0.000011479783],"domain_scores_gemma":[0.99995697,0.000005227689,0.000009939323,0.0000037555728,0.000008984415,0.000015205111],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014775856,0.00027198394,0.00018583448,0.0001686772,0.000102591264,0.000114777955,0.0001668668,0.0001374415,0.0014774842],"category_scores_gemma":[0.000096499025,0.000089824665,0.00016004281,0.00012798536,0.00013371652,0.00015260834,0.00011876362,0.00019787681,0.00029734973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036092423,0.00019972469,0.0002799687,0.00015619906,0.000012498194,0.00034559192,0.000057958638,0.0006254401,0.985797,0.00037163476,0.00013576388,0.011657335],"study_design_scores_gemma":[0.00014765777,0.0035846485,0.002030922,0.000013321392,0.00004545203,0.00040708933,0.000037103302,0.00074149447,0.98547876,0.00005361302,0.007450721,0.000009157622],"about_ca_topic_score_codex":0.0003621576,"about_ca_topic_score_gemma":0.0006989041,"teacher_disagreement_score":0.0014774842,"about_ca_system_score_codex":0.0001211673,"about_ca_system_score_gemma":0.00019431984,"threshold_uncertainty_score":0.0049426556},"labels":[],"label_agreement":null},{"id":"W2727802742","doi":"10.1016/j.bmcl.2017.07.018","title":"3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 colon cancer cells","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; College of Pharmacy and Nutrition, University of Saskatchewan; Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Chemistry; Glutathione; Mitochondrion; Mitochondrial permeability transition pore; Cytotoxicity; Reactive oxygen species; Substituent; Cancer cell; Biochemistry; Membrane permeability; Intracellular; Curcumin; Stereochemistry; Programmed cell death; Superoxide; In vitro; Apoptosis; Membrane; Cancer; Enzyme; Biology","score_opus":0.016502142322245766,"score_gpt":0.23794968461763927,"score_spread":0.2214475422953935,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2727802742","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9939949,0.0015866905,0.001420158,0.0001291379,0.00006474231,0.000042970063,0.00035698546,0.00013395012,0.0022705337],"genre_scores_gemma":[0.99526393,0.00088976906,0.0011697785,0.00003890987,0.0000151728555,0.000028953526,0.0004586326,0.000008467772,0.002126299],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989843,0.00001825013,0.00000960616,0.00001484342,0.000021024991,0.000037822214],"domain_scores_gemma":[0.9999318,0.000013731324,0.000016877546,0.000010220928,0.000008124368,0.000019241264],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013193538,0.00031173605,0.00023147976,0.00030524502,0.00016240127,0.00012411288,0.00018976572,0.00028409183,0.0015054467],"category_scores_gemma":[0.000090358335,0.00016749073,0.0002561964,0.0001837688,0.00015674872,0.00014673543,0.0001255721,0.0004627412,0.00030313982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00051093486,0.00009729858,0.00011340489,0.00006563164,0.000008561708,0.000101073165,0.000022767794,0.00013187266,0.9968656,0.00011516484,0.00010998803,0.0018577438],"study_design_scores_gemma":[0.00005920028,0.001528382,0.0026352936,0.000004235223,0.000015636133,0.00013354265,0.00001745029,0.0004272161,0.9939659,0.000029812061,0.0011792355,0.000004102829],"about_ca_topic_score_codex":0.0011144398,"about_ca_topic_score_gemma":0.00211407,"teacher_disagreement_score":0.0015054467,"about_ca_system_score_codex":0.00021301689,"about_ca_system_score_gemma":0.0002478964,"threshold_uncertainty_score":0.0050361753},"labels":[],"label_agreement":null},{"id":"W2729540152","doi":"10.1016/j.bmcl.2017.06.076","title":"Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canada Excellence Research Chairs, Government of Canada","keywords":"NMDA receptor; Chemistry; Analgesic; Pharmacology; Cyclohexanol; Memantine; Pharmacokinetics; Nociception; Central nervous system; Receptor; Biochemistry; Neuroscience; Medicine","score_opus":0.015201782173594794,"score_gpt":0.2518901716513617,"score_spread":0.23668838947776688,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2729540152","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94788843,0.011539601,0.022745395,0.0006619397,0.00019451702,0.0005192585,0.0012924301,0.00049424206,0.014664165],"genre_scores_gemma":[0.9758006,0.008205504,0.0073181475,0.00022539728,0.00003542794,0.00011681876,0.0007897183,0.000030374616,0.007478091],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999583,0.0000040432656,0.0000024511207,0.0000074977256,0.00000871028,0.000018971446],"domain_scores_gemma":[0.9999708,0.000003863417,0.000008351398,0.000003016656,0.0000057274033,0.0000082929055],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009365673,0.00042803443,0.0003781767,0.00021943056,0.00013606658,0.00031617846,0.0003389203,0.00019360504,0.0027061738],"category_scores_gemma":[0.000100143516,0.00014011597,0.00022716007,0.00018200772,0.0001591169,0.00024197155,0.00026218858,0.000449372,0.0005137985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006472509,0.00033002175,0.00029628346,0.00034829817,0.00004387579,0.0004714609,0.0000717658,0.0015192702,0.95180213,0.0012332507,0.0009679259,0.042268533],"study_design_scores_gemma":[0.00089061965,0.005438175,0.0026892154,0.00005682993,0.0001799616,0.00082997035,0.00011327695,0.0050488594,0.9557772,0.0005660667,0.028348524,0.000061374005],"about_ca_topic_score_codex":0.0009815411,"about_ca_topic_score_gemma":0.0033232362,"teacher_disagreement_score":0.0027061738,"about_ca_system_score_codex":0.00029696248,"about_ca_system_score_gemma":0.0003373102,"threshold_uncertainty_score":0.0090530515},"labels":[],"label_agreement":null},{"id":"W2737992338","doi":"10.1016/j.bmcl.2017.07.062","title":"Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre for Drug Research and Development","funders":"Australian Research Council; Queensland Government","keywords":"Chemistry; Stereochemistry; Metabolite; Dichloromethane; Fungus; Phosphodiesterase; Cyclobutane; DNA; Proton NMR; Strain (injury); Enzyme; Biochemistry; Organic chemistry; Botany","score_opus":0.019115019489831114,"score_gpt":0.2602495941028742,"score_spread":0.24113457461304308,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2737992338","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98069084,0.0071955156,0.0049930224,0.00016283334,0.000065915716,0.000114270544,0.0003832239,0.00012691008,0.006267433],"genre_scores_gemma":[0.9897522,0.0027940648,0.0031069485,0.00006330632,0.000011477288,0.000013014455,0.00047755433,0.000015834687,0.003765687],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999527,0.000005398309,0.0000028789113,0.000010859284,0.000011042028,0.000017065227],"domain_scores_gemma":[0.9999653,0.0000071626228,0.0000051254756,0.0000039878323,0.000004965716,0.000013459511],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000088548884,0.0002992147,0.00023286926,0.00019488428,0.00014390664,0.0001984741,0.00021342572,0.00024707263,0.00074832066],"category_scores_gemma":[0.00010052967,0.00009461561,0.00014716448,0.00011942433,0.00016794507,0.00010689674,0.00012182745,0.00033369556,0.00017174504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016823492,0.00002139371,0.00011144248,0.000066247485,0.000007460764,0.00012573217,0.000016150714,0.00012265783,0.99329466,0.000054789783,0.000052205545,0.005959054],"study_design_scores_gemma":[0.00008182586,0.00070351915,0.0035396153,0.000009648207,0.000044804558,0.0005952025,0.00003095936,0.0005158931,0.9860809,0.000042684896,0.008343235,0.000011728768],"about_ca_topic_score_codex":0.0023655477,"about_ca_topic_score_gemma":0.0023604443,"teacher_disagreement_score":0.0023655477,"about_ca_system_score_codex":0.0001499616,"about_ca_system_score_gemma":0.00021965116,"threshold_uncertainty_score":0.0047035217},"labels":[],"label_agreement":null},{"id":"W2738570752","doi":"10.1016/j.bmcl.2017.07.050","title":"Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA)","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ontario Institute of Technology","funders":"University of Ontario Institute of Technology","keywords":"Chemistry; Metabolite; GABAA receptor; Agonist; GABA receptor; Chemical synthesis; Chemical structure; Stereochemistry; Receptor; Pharmacology; Biochemistry; In vitro; Organic chemistry; Biology","score_opus":0.03354314679014244,"score_gpt":0.2950316159274613,"score_spread":0.2614884691373189,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2738570752","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8978947,0.0056404206,0.066057466,0.00058590906,0.0004355809,0.00027150704,0.0018329322,0.00084427005,0.026437279],"genre_scores_gemma":[0.97417974,0.0022629767,0.016371312,0.00008916508,0.00002607869,0.000060288115,0.0009032611,0.000088234,0.0060189595],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998723,0.000011043321,0.000012586731,0.000026366457,0.000030737152,0.000046894354],"domain_scores_gemma":[0.99991643,0.000006230683,0.000018423741,0.000013572331,0.000023515384,0.000021777149],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013456968,0.0004739756,0.00026618308,0.00026606128,0.00025377504,0.00032957408,0.0003279105,0.0003627787,0.0013259484],"category_scores_gemma":[0.00018202055,0.00015185901,0.00026108525,0.00033632363,0.00013475382,0.0003668537,0.0003676693,0.00067587505,0.0010499906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007597373,0.0000364175,0.000068306326,0.00008789353,0.00001011127,0.00021388204,0.000030399595,0.00034567056,0.98947364,0.00084724557,0.00021891964,0.008591547],"study_design_scores_gemma":[0.000012766405,0.00016353969,0.0002399064,0.000005737721,0.000015190324,0.00020751043,0.000013305533,0.0006705843,0.991286,0.00010778597,0.00726744,0.000010218073],"about_ca_topic_score_codex":0.0012066689,"about_ca_topic_score_gemma":0.001801604,"teacher_disagreement_score":0.0013259484,"about_ca_system_score_codex":0.00038324174,"about_ca_system_score_gemma":0.0007567317,"threshold_uncertainty_score":0.004435718},"labels":[],"label_agreement":null},{"id":"W2739411391","doi":"10.1016/j.bmcl.2017.07.051","title":"Iodine-catalyzed Csp3-H functionalization of methylhetarenes: One-pot synthesis and cytotoxic evaluation of heteroarenyl-benzimidazoles and benzothiazole","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"King Saud University; Institute of Population and Public Health; University Grants Committee; University Grants Commission; Council of Scientific and Industrial Research, India","keywords":"Benzothiazole; Chemistry; Amination; Combinatorial chemistry; Surface modification; Cytotoxicity; Cytotoxic T cell; Halogenation; Iodine; Cancer cell lines; Catalysis; Organic chemistry; In vitro; Biochemistry; Cancer; Cancer cell","score_opus":0.051880844454870415,"score_gpt":0.2942877800838115,"score_spread":0.2424069356289411,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2739411391","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98115784,0.002535889,0.008821303,0.00014022505,0.000046583056,0.00008557744,0.00037690575,0.00013627691,0.0066993614],"genre_scores_gemma":[0.9953988,0.0009416384,0.0017181119,0.000031827414,0.000007778858,0.00001842936,0.00016536123,0.000013119822,0.0017047714],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998735,0.000016055947,0.000008869337,0.000016764021,0.000032613305,0.00005218146],"domain_scores_gemma":[0.99995244,0.000009283848,0.000011475858,0.000007852544,0.00000866901,0.0000102506765],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002201034,0.00039848327,0.0002377105,0.00023517237,0.00020652269,0.0001305814,0.0005710887,0.00036518334,0.0018750026],"category_scores_gemma":[0.00013104492,0.00014531575,0.0002984631,0.00023600683,0.00024502302,0.00023429036,0.00029133254,0.00034773813,0.00039993567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014842542,0.000054978555,0.0001030055,0.00009152547,0.000011288007,0.00018648738,0.000054330885,0.00041356418,0.99352443,0.0003754579,0.00012411558,0.0049125194],"study_design_scores_gemma":[0.000021480291,0.0005201499,0.0008245525,0.000004380991,0.000014092763,0.00014825487,0.000015456084,0.00059543643,0.99609214,0.000051574167,0.0017021942,0.0000103071225],"about_ca_topic_score_codex":0.0012000838,"about_ca_topic_score_gemma":0.003385094,"teacher_disagreement_score":0.0018750026,"about_ca_system_score_codex":0.0002938546,"about_ca_system_score_gemma":0.00027043273,"threshold_uncertainty_score":0.0062725544},"labels":[],"label_agreement":null},{"id":"W2739896357","doi":"10.1016/j.bmcl.2017.08.003","title":"1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Chemistry; Carboxylic acid; Cell culture; Stereochemistry; Lymphoma; Cell cycle; Chemical synthesis; Cell cycle checkpoint; Cell; Interphase; Structure–activity relationship; Pharmacology; In vitro; Biochemistry; Cell biology; Immunology; Biology","score_opus":0.028808908964024004,"score_gpt":0.2717763278232595,"score_spread":0.2429674188592355,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2739896357","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.89889956,0.045924332,0.011237669,0.00097264716,0.00070012367,0.0002609972,0.001444731,0.0006395719,0.03992035],"genre_scores_gemma":[0.97655576,0.01209116,0.0029720573,0.00014638572,0.000074068455,0.000098852215,0.0004570505,0.000030536867,0.007574179],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990225,0.00002360562,0.000007342205,0.000011687403,0.000019575404,0.000035473666],"domain_scores_gemma":[0.99993634,0.0000088944425,0.000016827127,0.000007595322,0.000010409055,0.00001997423],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021077512,0.00035349638,0.00040950283,0.00027910367,0.00017620079,0.00027042115,0.00048892293,0.0003508802,0.002319675],"category_scores_gemma":[0.00016069622,0.00015916562,0.00018584722,0.00020886457,0.00020227846,0.00021492483,0.0002221853,0.0005965198,0.0008910716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012963277,0.00019650442,0.0002572571,0.00045648406,0.000021113163,0.0005741088,0.00008261708,0.0017839734,0.9669102,0.0021428915,0.0011151414,0.025163423],"study_design_scores_gemma":[0.0009385312,0.005883372,0.004287447,0.00008110401,0.00008508597,0.0014198967,0.000054880387,0.0036259454,0.93391836,0.00032843178,0.04932742,0.00004962036],"about_ca_topic_score_codex":0.0007409581,"about_ca_topic_score_gemma":0.0014861561,"teacher_disagreement_score":0.002319675,"about_ca_system_score_codex":0.0003836184,"about_ca_system_score_gemma":0.00038262515,"threshold_uncertainty_score":0.007760048},"labels":[],"label_agreement":null},{"id":"W2746979828","doi":"10.1016/j.bmcl.2017.08.034","title":"Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; American Asthma Foundation","keywords":"Chemistry; Indole test; Moiety; Stereochemistry; Side chain; Alkyl; Mediator; Receptor; Structure–activity relationship; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry","score_opus":0.04182984416115467,"score_gpt":0.2816091427995239,"score_spread":0.23977929863836925,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2746979828","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99389404,0.0036392817,0.0007703077,0.00008187353,0.000035303045,0.00005231542,0.00027437368,0.000024267983,0.00122824],"genre_scores_gemma":[0.9926811,0.0031783197,0.0007256247,0.00010190904,0.000026746298,0.0000362289,0.00081004034,0.0000074419477,0.00243263],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990046,0.00002435878,0.000008270808,0.000014516966,0.000016969076,0.00003550704],"domain_scores_gemma":[0.9999335,0.000013952905,0.000014523345,0.0000066527923,0.0000114425275,0.00001991145],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022426728,0.00029521566,0.00034334548,0.00024131262,0.00014403953,0.00020047266,0.00029637048,0.00019426926,0.0020409129],"category_scores_gemma":[0.00017712591,0.00017657685,0.00038379963,0.00016529791,0.00014426248,0.00019334714,0.0001061705,0.00049709476,0.0003541695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0030143263,0.00104014,0.00037822317,0.00009804932,0.000091775524,0.00011549617,0.00004230664,0.0005410124,0.98748827,0.00018326307,0.00018298923,0.0068241768],"study_design_scores_gemma":[0.0022790409,0.046148602,0.015672756,0.000030217589,0.00068384665,0.0010801802,0.00011774937,0.0038689214,0.9206136,0.00014805647,0.009311261,0.000045719105],"about_ca_topic_score_codex":0.00055614556,"about_ca_topic_score_gemma":0.0012396518,"teacher_disagreement_score":0.0020409129,"about_ca_system_score_codex":0.0001655219,"about_ca_system_score_gemma":0.00014012572,"threshold_uncertainty_score":0.006827593},"labels":[],"label_agreement":null},{"id":"W2754507185","doi":"10.1016/j.bmcl.2017.09.026","title":"Discovery of potent antiviral (HSV-1) quinazolinones and initial structure-activity relationship studies","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Stanley Medical Research Institute","keywords":"Herpes simplex virus; Chemistry; Structure–activity relationship; HSL and HSV; Chemical synthesis; Virus; Toxicity; In vitro; Stereochemistry; Pharmacology; Combinatorial chemistry; Virology; Biochemistry; Organic chemistry; Biology","score_opus":0.03927135312393834,"score_gpt":0.3076443799191132,"score_spread":0.26837302679517483,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2754507185","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9426805,0.0338115,0.011435209,0.000688609,0.000063627645,0.0007659454,0.0013002608,0.00010927776,0.0091450615],"genre_scores_gemma":[0.9776138,0.013350937,0.0044535026,0.00021431978,0.000039876744,0.00009563288,0.0011367257,0.000015409583,0.0030798758],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998123,0.00004574549,0.00001359732,0.00003069263,0.00004174074,0.000055957968],"domain_scores_gemma":[0.9998037,0.00007129502,0.000024642071,0.000013799399,0.00005184914,0.000034658093],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006267644,0.0005289178,0.00045881298,0.00047259894,0.00021961327,0.0006459998,0.00039744584,0.00026819602,0.00239434],"category_scores_gemma":[0.00070903526,0.00021808605,0.00037048917,0.00028745722,0.00030798846,0.00053768983,0.00029478845,0.0006339333,0.00047073464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008618994,0.000856507,0.0013225543,0.00034993238,0.00005870252,0.00028521862,0.00019658876,0.002412769,0.96149874,0.0018356473,0.00047738262,0.029844055],"study_design_scores_gemma":[0.00040792924,0.010421275,0.007666274,0.000055016746,0.00016836953,0.00080770225,0.00014385213,0.0019465012,0.95927507,0.0010462017,0.01801916,0.000042777552],"about_ca_topic_score_codex":0.0011031112,"about_ca_topic_score_gemma":0.0018594353,"teacher_disagreement_score":0.00239434,"about_ca_system_score_codex":0.0007141556,"about_ca_system_score_gemma":0.00034957586,"threshold_uncertainty_score":0.008009911},"labels":[],"label_agreement":null},{"id":"W2789000126","doi":"10.1016/j.bmcl.2018.01.044","title":"Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Wellcome Trust; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institute of Allergy and Infectious Diseases; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Pfizer","keywords":"Chemistry; Regorafenib; Kinase; Binding site; Small molecule; Cell biology; Biochemistry; Biology; Genetics","score_opus":0.020438262946198577,"score_gpt":0.2594280264805116,"score_spread":0.23898976353431303,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2789000126","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8861964,0.0057227607,0.09189656,0.0005046695,0.00009846244,0.0005380855,0.00064556743,0.00052897766,0.013868529],"genre_scores_gemma":[0.96377033,0.0025050153,0.03076788,0.00019154779,0.000014060635,0.00011909453,0.00036050554,0.000024790215,0.002246803],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999119,0.000014700419,0.000007852675,0.000018425135,0.000024099665,0.000023038534],"domain_scores_gemma":[0.9999665,0.0000035608798,0.000011170457,0.0000026104626,0.000006481917,0.0000096656295],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017980326,0.00036901244,0.00028999796,0.00019212013,0.00011836091,0.00028068584,0.0003052584,0.00026737142,0.0009904465],"category_scores_gemma":[0.000104111925,0.00014942321,0.0002690376,0.00016513676,0.00013420626,0.00027847267,0.0002259586,0.00044387867,0.0005532174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001764161,0.00011849576,0.00017047708,0.00015680782,0.000019092338,0.00023492635,0.000041193773,0.0053201066,0.9779283,0.0016645329,0.0003115416,0.013858157],"study_design_scores_gemma":[0.0001871251,0.0021066517,0.0007183,0.000021237776,0.000055910932,0.0006710966,0.000037242015,0.011139878,0.95987403,0.00067948416,0.02447155,0.000037417663],"about_ca_topic_score_codex":0.000209383,"about_ca_topic_score_gemma":0.0004933663,"teacher_disagreement_score":0.0009904465,"about_ca_system_score_codex":0.0002988908,"about_ca_system_score_gemma":0.00028094393,"threshold_uncertainty_score":0.0033133626},"labels":[],"label_agreement":null},{"id":"W2789281625","doi":"10.1016/j.bmcl.2018.01.067","title":"Synthesis and evaluation of bifunctional tetrahydroxamate chelators for labeling antibodies with 89Zr for imaging with positron emission tomography","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Trastuzumab; Biodistribution; Chemistry; Bifunctional; Positron emission tomography; Linker; Conjugate; Chelation; In vivo; Combinatorial chemistry; In vitro; Nuclear medicine; Biochemistry; Cancer; Organic chemistry","score_opus":0.01972146928866758,"score_gpt":0.2968032684336272,"score_spread":0.2770817991449596,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2789281625","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9734408,0.0037224395,0.018935837,0.00016944512,0.000049819766,0.00019126046,0.00034627083,0.00020717081,0.002936898],"genre_scores_gemma":[0.9765594,0.0016485654,0.018186383,0.000080302605,0.000016554068,0.000074826996,0.00075830315,0.00006399266,0.002611796],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998344,0.000038633676,0.00001568832,0.000030388303,0.00003794139,0.000042848817],"domain_scores_gemma":[0.99986136,0.00001562953,0.000040652034,0.000017552788,0.000040432347,0.000024423562],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046166172,0.00034869782,0.0003021873,0.00022688581,0.00020094552,0.00028895418,0.00037317057,0.0004510659,0.00062350626],"category_scores_gemma":[0.0002778444,0.00016995342,0.00019439323,0.00018427274,0.00018119646,0.00022362395,0.00022357557,0.00024121278,0.00035328735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001821201,0.000032022395,0.00013727782,0.00007818387,0.00001058581,0.000058790065,0.000031869247,0.00019436584,0.99571335,0.00022496766,0.00010938586,0.0032271661],"study_design_scores_gemma":[0.000028913231,0.00040169945,0.00038544854,0.0000068102117,0.00002129386,0.00012761983,0.00001209414,0.00063768646,0.9948329,0.000023953618,0.0035150493,0.000006438697],"about_ca_topic_score_codex":0.0006711697,"about_ca_topic_score_gemma":0.0013947742,"teacher_disagreement_score":0.0006711697,"about_ca_system_score_codex":0.00042885102,"about_ca_system_score_gemma":0.00024712188,"threshold_uncertainty_score":0.0031116009},"labels":[],"label_agreement":null},{"id":"W2789534911","doi":"10.1016/j.bmcl.2018.03.039","title":"Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute on Minority Health and Health Disparities; National Institute of General Medical Sciences; University of British Columbia","keywords":"Quinoline; Sulfone; Trypanosoma brucei; Chemistry; Thiol; Stereochemistry; Cysteine protease; Combinatorial chemistry; Cysteine; Biochemistry; Enzyme; Organic chemistry","score_opus":0.022843228638641137,"score_gpt":0.3062659064758424,"score_spread":0.28342267783720126,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2789534911","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95935625,0.010603333,0.014998742,0.0008229757,0.00018307299,0.00023150918,0.0004241972,0.0001806298,0.01319939],"genre_scores_gemma":[0.9847193,0.0046634963,0.0050698565,0.00016421011,0.000029035267,0.000030792522,0.00023540323,0.000008775073,0.0050792336],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999734,0.000005674615,0.0000016752181,0.0000047069793,0.0000059831887,0.000008586475],"domain_scores_gemma":[0.9999701,0.0000041896787,0.000004482652,0.00000299069,0.00000810523,0.000010093031],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014340419,0.00019817286,0.00013273819,0.00017496792,0.00014894568,0.0001511366,0.00026881302,0.00023653825,0.0013571086],"category_scores_gemma":[0.00008827514,0.00007490777,0.00017285647,0.00009227143,0.00015493967,0.00014886716,0.00019476021,0.00028181364,0.0003075146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023594631,0.00011992294,0.00034309266,0.00024279198,0.000019976389,0.0007721809,0.00009832817,0.00056415866,0.9752662,0.0015611721,0.0005793522,0.02019694],"study_design_scores_gemma":[0.00024321256,0.006497902,0.0033410522,0.000059720034,0.000109372195,0.0012942872,0.000086068634,0.002956328,0.9419128,0.0004816964,0.042986516,0.000031078253],"about_ca_topic_score_codex":0.0004899979,"about_ca_topic_score_gemma":0.000988215,"teacher_disagreement_score":0.0013571086,"about_ca_system_score_codex":0.00013279048,"about_ca_system_score_gemma":0.00020420081,"threshold_uncertainty_score":0.0045399666},"labels":[],"label_agreement":null},{"id":"W2790900967","doi":"10.1016/j.bmcl.2018.03.036","title":"One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Stanley Medical Research Institute","keywords":"Toxoplasma gondii; Chemistry; Substituent; Moiety; Stereochemistry; Structure–activity relationship; Parasite hosting; IC50; In vitro; Biochemistry; Biology; Immunology; Antibody","score_opus":0.010415012420662846,"score_gpt":0.21216604131943026,"score_spread":0.20175102889876742,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2790900967","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93260276,0.0059509403,0.03596416,0.0003851861,0.00032499642,0.00062007114,0.0019169343,0.000650978,0.021584092],"genre_scores_gemma":[0.97506034,0.0022108045,0.016221095,0.00011719796,0.000026133448,0.00016667311,0.00046547805,0.00005858571,0.0056737233],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987197,0.000014502051,0.000013416209,0.000027704284,0.000020014339,0.000052283343],"domain_scores_gemma":[0.99992,0.000010271502,0.0000194599,0.000011641556,0.000015098777,0.000023463474],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025948658,0.00083220954,0.000397508,0.0003650149,0.00030136676,0.00025019844,0.00084668753,0.00039824762,0.002594916],"category_scores_gemma":[0.00015624808,0.0002753862,0.0003071867,0.000359344,0.000229524,0.00039140732,0.00046025476,0.00049582653,0.0009536049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046901702,0.00030699954,0.00032365028,0.00060601387,0.000054078315,0.00074320997,0.00018916289,0.0025048892,0.96082044,0.0025030132,0.0011299005,0.030349655],"study_design_scores_gemma":[0.0001758972,0.0024703767,0.0017389372,0.000034770284,0.00008050259,0.0005463609,0.000057976322,0.0027968504,0.9756565,0.00043380144,0.01594333,0.00006470866],"about_ca_topic_score_codex":0.00063990185,"about_ca_topic_score_gemma":0.002440693,"teacher_disagreement_score":0.002594916,"about_ca_system_score_codex":0.00042070658,"about_ca_system_score_gemma":0.00058071985,"threshold_uncertainty_score":0.00868088},"labels":[],"label_agreement":null},{"id":"W2791360312","doi":"10.1016/j.bmcl.2018.01.046","title":"Corrigendum to “1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents” [Bioorg. Med. Chem. Lett. 27 (2017) 4471–4477]","year":2018,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Chemistry; Carboxylic acid; Stereochemistry; Combinatorial chemistry; Medicinal chemistry; Organic chemistry","score_opus":0.0333362305430851,"score_gpt":0.2627134865870802,"score_spread":0.22937725604399511,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2791360312","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00023290778,0.008766572,0.000786138,0.037398096,0.9406783,0.00006817255,0.0007175673,0.00037235525,0.010979993],"genre_scores_gemma":[0.014440146,0.03524924,0.0032598202,0.072635256,0.21017899,0.00021316645,0.003203044,0.0005388469,0.66028154],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9979267,0.00019743746,0.0002629883,0.0004294911,0.00082583807,0.0003574583],"domain_scores_gemma":[0.99475443,0.0009474249,0.0003926643,0.00030388456,0.0030104667,0.00059117127],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017668313,0.0027205518,0.002782691,0.0022646226,0.0026416793,0.0019714772,0.0042121024,0.005937125,0.12202427],"category_scores_gemma":[0.010035746,0.0013234427,0.0022143174,0.0019005745,0.0014301206,0.0022618738,0.001886012,0.004961852,0.07237885],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007386545,0.00002484307,0.000049027098,0.0002991046,0.00001954069,0.00044088217,0.000017588174,0.00008818526,0.0006071859,0.0006444786,0.9861205,0.011614706],"study_design_scores_gemma":[0.000030809537,0.000048411395,0.0005138485,0.00008040203,0.000034931894,0.0003029255,0.000022135393,0.00013120285,0.0014627783,0.0004034747,0.9969392,0.000029897676],"about_ca_topic_score_codex":0.0112019945,"about_ca_topic_score_gemma":0.01726002,"teacher_disagreement_score":0.12202427,"about_ca_system_score_codex":0.004286999,"about_ca_system_score_gemma":0.002978286,"threshold_uncertainty_score":0.40821183},"labels":[],"label_agreement":null},{"id":"W2792339230","doi":"10.1016/j.bmcl.2018.01.053","title":"Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"ADME; Chemistry; In vivo; Pharmacology; Pharmacokinetics; Bioavailability; Microtubule polymerization; Microtubule; In vitro; Biochemistry; Tubulin; Biology; Cell biology","score_opus":0.01528710306998185,"score_gpt":0.2838546049290552,"score_spread":0.2685675018590733,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2792339230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9955052,0.0011584974,0.00053771754,0.00014869081,0.00007984147,0.00005823644,0.00035792225,0.00008261972,0.0020712381],"genre_scores_gemma":[0.99475205,0.0013667635,0.00044874882,0.000051480765,0.00006494064,0.00006220488,0.0006539695,0.00002318533,0.0025765458],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984956,0.000041538577,0.000009306045,0.000021302765,0.000019771443,0.000058551803],"domain_scores_gemma":[0.99974614,0.00007063117,0.000047225014,0.00003321339,0.000017251843,0.00008547595],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034307686,0.0005131679,0.00045067153,0.00045076478,0.0003106964,0.0002918527,0.0005199678,0.00048038445,0.0023858855],"category_scores_gemma":[0.00037179777,0.00030524647,0.00044671292,0.00026853377,0.00043665105,0.0004683687,0.000096645446,0.0014833736,0.0003929527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.020731442,0.007117652,0.00068228325,0.00016897434,0.00015948614,0.00032883545,0.00012958862,0.0022414355,0.9489131,0.00070352847,0.0009591617,0.017864507],"study_design_scores_gemma":[0.0021029334,0.048706718,0.0062458487,0.000022619151,0.00021563873,0.0003418815,0.00007462894,0.0025891915,0.937083,0.0002395386,0.0023498284,0.000028217426],"about_ca_topic_score_codex":0.0013155662,"about_ca_topic_score_gemma":0.0021932966,"teacher_disagreement_score":0.0023858855,"about_ca_system_score_codex":0.0003177838,"about_ca_system_score_gemma":0.00045119642,"threshold_uncertainty_score":0.007981598},"labels":[],"label_agreement":null},{"id":"W2793343392","doi":"10.1016/j.bmcl.2018.03.016","title":"Design, synthesis, nuclear localization, and biological activity of a fluorescent duocarmycin analog, HxTfA","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Cancer Research UK; National Science Foundation","keywords":"Chemistry; Confocal microscopy; Confocal; Cytotoxicity; Fluorescence; A549 cell; Fluorescence microscope; In vitro; Biological activity; Biochemistry; Biophysics; Cell biology; Biology","score_opus":0.016582583029481752,"score_gpt":0.22841890937190773,"score_spread":0.21183632634242597,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2793343392","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9708839,0.0009762666,0.022312993,0.0002747823,0.00003895978,0.00017349751,0.00057479035,0.00020828398,0.004556466],"genre_scores_gemma":[0.98396516,0.00052573957,0.011628468,0.000054789773,0.00000851331,0.00005656258,0.0005143002,0.000040949402,0.0032053553],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989223,0.00001672264,0.000012579732,0.000032296753,0.00002113037,0.000024990935],"domain_scores_gemma":[0.9998677,0.00002403108,0.000037166858,0.000022821187,0.000018313605,0.000029871244],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023426466,0.00019639675,0.00017894093,0.00012013693,0.00023192202,0.00035808672,0.00035520032,0.00022365103,0.0010960491],"category_scores_gemma":[0.00021567143,0.00013730487,0.00016104228,0.00014877491,0.00023823373,0.00023479306,0.0001396362,0.00033864222,0.00027979774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016481223,0.000041683852,0.00014850021,0.000056327026,0.0000038237195,0.000062893094,0.000044630986,0.0005579563,0.99279165,0.0010186943,0.00007947916,0.0050295624],"study_design_scores_gemma":[0.0000111631625,0.00008104224,0.00017402474,0.0000018182203,0.000003506891,0.000044949033,0.0000066909547,0.0004887935,0.9970175,0.000028146149,0.0021394787,0.0000028638003],"about_ca_topic_score_codex":0.0013284986,"about_ca_topic_score_gemma":0.0013817094,"teacher_disagreement_score":0.0013284986,"about_ca_system_score_codex":0.00068229315,"about_ca_system_score_gemma":0.00041422018,"threshold_uncertainty_score":0.004950404},"labels":[],"label_agreement":null},{"id":"W2799305391","doi":"10.1016/j.bmcl.2018.05.015","title":"Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute; Université de Sherbrooke","funders":"National Institute on Drug Abuse; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Vlaamse regering; Agentschap Innoveren en Ondernemen","keywords":"Chemistry; Stereochemistry; Moiety; Dermorphin; Opioid receptor; Affinities; Phenylalanine; Opioid; Chemical synthesis; Tyrosine; Opioid peptide; Combinatorial chemistry; Molecular model; Side chain; Chemical space; Radioligand; Receptor; Drug discovery; Amino acid; Biochemistry; In vitro; Organic chemistry","score_opus":0.010290246344072405,"score_gpt":0.2608430784333973,"score_spread":0.25055283208932494,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2799305391","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9862433,0.0010110562,0.0078097205,0.00016937885,0.0000427358,0.000071382296,0.00014207292,0.0001367153,0.004373711],"genre_scores_gemma":[0.9956417,0.0006652569,0.002180395,0.00007434685,0.000012478611,0.000030976422,0.00009404401,0.000019300527,0.0012814855],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998171,0.000033466746,0.000009733194,0.000030176498,0.00002203578,0.00008751016],"domain_scores_gemma":[0.9998585,0.00003987568,0.00003005843,0.00001822564,0.000019410885,0.0000339325],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036513337,0.0005485705,0.00024710043,0.00020373445,0.00036489102,0.00018509616,0.00041243783,0.0003472326,0.0029340393],"category_scores_gemma":[0.00025731686,0.00020541936,0.00029919358,0.00023632862,0.0002807458,0.00029821706,0.00034304694,0.00065093004,0.00040577797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00076186523,0.00006655911,0.0001465606,0.00012925727,0.000022176331,0.00027699076,0.000114100374,0.0007484698,0.9912212,0.0006340587,0.00015096739,0.0057275933],"study_design_scores_gemma":[0.00006218297,0.0012136718,0.00048974267,0.000007935197,0.000030489986,0.00013851198,0.000055029883,0.00077932497,0.995434,0.000119037766,0.0016512665,0.000018786632],"about_ca_topic_score_codex":0.00096741813,"about_ca_topic_score_gemma":0.0020221071,"teacher_disagreement_score":0.0029340393,"about_ca_system_score_codex":0.0002317474,"about_ca_system_score_gemma":0.00029841074,"threshold_uncertainty_score":0.009815335},"labels":[],"label_agreement":null},{"id":"W2801452578","doi":"10.1016/j.bmcl.2018.03.063","title":"Modular synthesis of new C-aryl-nucleosides and their anti-CML activity","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Association Laurette Fugain; Centre National pour la Recherche Scientifique et Technique; European Cooperation in Science and Technology; Providence Health Care","keywords":"Chemistry; Aryl; Myeloid leukemia; K562 cells; Imatinib; Phenanthrenes; Cell culture; Stereochemistry; Combinatorial chemistry; Apoptosis; Cancer research; Biochemistry; Biology","score_opus":0.013407759361822546,"score_gpt":0.22499021290768173,"score_spread":0.2115824535458592,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2801452578","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9309712,0.008138595,0.029497387,0.00040968313,0.00026163043,0.0003939621,0.0015216394,0.0005982581,0.028207693],"genre_scores_gemma":[0.97100824,0.0046519926,0.015015234,0.00018659068,0.00005200555,0.00015807137,0.00069310126,0.000049443446,0.008185385],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998919,0.000013165752,0.000010417649,0.000019521158,0.000022052755,0.000042954307],"domain_scores_gemma":[0.9999492,0.0000052483947,0.000012557257,0.000007035476,0.0000073794467,0.000018539422],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020834724,0.0005476064,0.00028237575,0.0002599489,0.00019037629,0.00034745046,0.00042975665,0.0003650711,0.0029151912],"category_scores_gemma":[0.00013205167,0.00017206122,0.00031812387,0.00028610052,0.00019995398,0.00038144604,0.0004702552,0.0006640599,0.0011024069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031099125,0.00014227291,0.00018606761,0.00025319387,0.00003357495,0.0005465966,0.00010635343,0.001299558,0.9661794,0.0033849096,0.000578897,0.026978167],"study_design_scores_gemma":[0.000066213826,0.001096594,0.00072697224,0.000018029423,0.000045063607,0.0003858695,0.000019182084,0.0007927339,0.97788674,0.00037127998,0.018565789,0.000025402198],"about_ca_topic_score_codex":0.00032790238,"about_ca_topic_score_gemma":0.00083883427,"teacher_disagreement_score":0.0029151912,"about_ca_system_score_codex":0.0003083328,"about_ca_system_score_gemma":0.0003624952,"threshold_uncertainty_score":0.009752333},"labels":[],"label_agreement":null},{"id":"W2806764442","doi":"10.1016/j.bmcl.2018.06.014","title":"Synthesis and evaluation of an 18F-labeled boramino acid analog of aminosuberic acid for PET imaging of the antiporter system xC−","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; TRIUMF; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Organic anion transporter 1; Positron emission tomography; Amino acid transporter; Pharmacokinetics; Transporter; Amino acid; Pet imaging; Antiporter; Biochemistry; Pharmacology; Membrane; Nuclear medicine","score_opus":0.00960120276753692,"score_gpt":0.2450307466656083,"score_spread":0.2354295438980714,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2806764442","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95961446,0.0036218278,0.030494815,0.00018775743,0.0000695989,0.0003362133,0.00045164436,0.00011911914,0.005104665],"genre_scores_gemma":[0.9560763,0.0022341004,0.035049744,0.00009827182,0.000020275089,0.000105275554,0.001000573,0.00006303556,0.005352461],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987113,0.00003197956,0.000008945019,0.000028590557,0.000025613163,0.000033704044],"domain_scores_gemma":[0.99989474,0.000015128202,0.00001820752,0.00001526664,0.000026724403,0.000029890976],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038988882,0.0003463089,0.00030647177,0.00015097958,0.00025769198,0.00037719085,0.0005116701,0.0005833032,0.0008587472],"category_scores_gemma":[0.00017677058,0.00017195824,0.0001957512,0.00018151327,0.00015274387,0.00034746734,0.00015098405,0.00038881932,0.00042437378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010821223,0.00003441115,0.00005350104,0.000053826217,0.0000062849545,0.000111641406,0.000024541652,0.00016677521,0.9971795,0.00022584383,0.000043544387,0.0019918724],"study_design_scores_gemma":[0.00001537992,0.00023239788,0.00016498019,0.0000026964233,0.000010097668,0.0001697411,0.000008731164,0.00041281112,0.995998,0.000015182554,0.0029652952,0.0000045950933],"about_ca_topic_score_codex":0.0008839252,"about_ca_topic_score_gemma":0.00092388195,"teacher_disagreement_score":0.0008839252,"about_ca_system_score_codex":0.00035443652,"about_ca_system_score_gemma":0.0003276377,"threshold_uncertainty_score":0.0028728247},"labels":[],"label_agreement":null},{"id":"W2806848460","doi":"10.1016/j.bmcl.2018.06.002","title":"Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2′-deoxyuridine for hepatocellular carcinoma","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Ionis Pharmaceuticals","keywords":"Chemistry; Asialoglycoprotein receptor; Linker; Deoxyuridine; Hepatocellular carcinoma; Nucleoside; Nucleoside analogue; Biochemistry; Galactosamine; Stereochemistry; Cancer research; In vitro; DNA; Galactose","score_opus":0.030167575354186425,"score_gpt":0.2768013349439604,"score_spread":0.246633759589774,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2806848460","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99034286,0.0027137354,0.0045650266,0.00007847266,0.000030319152,0.00006718718,0.000084860665,0.000035219535,0.0020822962],"genre_scores_gemma":[0.9928388,0.0020079555,0.002860454,0.000037223992,0.000011664147,0.00003056407,0.00011128738,0.000017079417,0.002084917],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998541,0.00004107049,0.000008446785,0.000023859917,0.00003086098,0.00004163387],"domain_scores_gemma":[0.9999261,0.000029446843,0.0000132035975,0.0000061827386,0.000015919397,0.000009035589],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044256344,0.00026162248,0.00038789763,0.00017908447,0.00023707653,0.0002677022,0.00029690046,0.00030658604,0.0008374693],"category_scores_gemma":[0.00019568215,0.0001913408,0.0003661568,0.00016798734,0.0002444278,0.00034985712,0.00011907387,0.0003492263,0.00025448448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007873489,0.000023808087,0.00004718607,0.000049559116,0.0000048140573,0.00003699561,0.000035761957,0.0001190435,0.99855024,0.00010073448,0.000012747646,0.0009404376],"study_design_scores_gemma":[0.0000105825075,0.00046221435,0.0005424453,0.0000020364114,0.00002405972,0.00009225637,0.000023040107,0.0005419903,0.9974324,0.000008753149,0.0008572064,0.0000030087544],"about_ca_topic_score_codex":0.0044411635,"about_ca_topic_score_gemma":0.0032247747,"teacher_disagreement_score":0.0044411635,"about_ca_system_score_codex":0.00055110623,"about_ca_system_score_gemma":0.0002693407,"threshold_uncertainty_score":0.008830667},"labels":[],"label_agreement":null},{"id":"W2808733627","doi":"10.1016/j.bmcl.2018.06.038","title":"Design and synthesis of bridged piperidine and piperazine isosteres","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Servier; Université de Montréal","keywords":"Piperidine; Chemistry; Piperazine; Agonist; hERG; ADME; Stereochemistry; Morpholine; Chemical synthesis; Antagonist; Combinatorial chemistry; Receptor; In vitro; Organic chemistry; Biochemistry","score_opus":0.008997401335006476,"score_gpt":0.21544804815682364,"score_spread":0.20645064682181716,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2808733627","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8765872,0.016661571,0.07934503,0.0009104954,0.0004909521,0.00069480605,0.0011626766,0.00054199866,0.023605356],"genre_scores_gemma":[0.9484648,0.009440564,0.026347842,0.00037526744,0.00006050084,0.00029128522,0.0007765303,0.000057299945,0.014185953],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989605,0.000018326338,0.000011026387,0.000020583271,0.000017065466,0.000036844922],"domain_scores_gemma":[0.9999167,0.000011616653,0.000021031388,0.000012445414,0.000013774778,0.00002448219],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036404215,0.00041222456,0.0003288375,0.0002398981,0.00016438315,0.000246292,0.0006897798,0.00036167193,0.0035699846],"category_scores_gemma":[0.00031040178,0.00025685455,0.00026347887,0.00024067087,0.00019299425,0.0005312739,0.0004537978,0.00085297297,0.0009145182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00060715474,0.00028121058,0.00020767938,0.0010110975,0.000050663708,0.0009635518,0.00040106662,0.0068979994,0.92921805,0.010734661,0.0013871561,0.048239753],"study_design_scores_gemma":[0.00028658778,0.00359831,0.00079013593,0.00010460529,0.000083703475,0.0006458641,0.0001080562,0.0049543055,0.9371432,0.0011745286,0.051042337,0.000068384055],"about_ca_topic_score_codex":0.00021874328,"about_ca_topic_score_gemma":0.0005577639,"teacher_disagreement_score":0.0035699846,"about_ca_system_score_codex":0.00031640704,"about_ca_system_score_gemma":0.00027784493,"threshold_uncertainty_score":0.011942804},"labels":[],"label_agreement":null},{"id":"W2808865154","doi":"10.1016/j.bmcl.2018.06.040","title":"ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McMaster University","keywords":"Chemistry; Rho-associated protein kinase; Structure–activity relationship; Kinase; Enzyme inhibitor; Protein kinase A; Pharmacology; Potency; Selectivity; Stereochemistry; In vitro; Biochemistry","score_opus":0.016500964170654348,"score_gpt":0.22535824981902758,"score_spread":0.20885728564837322,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2808865154","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91770387,0.022752926,0.034213312,0.0010182126,0.00020169266,0.00088020985,0.0028338456,0.0006280865,0.019767806],"genre_scores_gemma":[0.944943,0.015612061,0.020587182,0.0004185763,0.000060484293,0.00037444243,0.003351505,0.00007633006,0.014576223],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999876,0.000018348792,0.000010758754,0.000018275408,0.000032506043,0.000044035693],"domain_scores_gemma":[0.9999496,0.0000059095814,0.000012153134,0.000005265593,0.0000135297205,0.000013467952],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028825446,0.00048852514,0.00045215507,0.0003839744,0.00024491208,0.00031642843,0.00070388056,0.000325528,0.0018961122],"category_scores_gemma":[0.00018686289,0.00020535025,0.00044014386,0.00017451106,0.00018898603,0.00032573877,0.00024244333,0.0006644299,0.0008100009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009037019,0.0005924532,0.00036581658,0.00038806253,0.00006996109,0.00036917411,0.00011128934,0.005447053,0.9468238,0.0029391695,0.0016783689,0.040311042],"study_design_scores_gemma":[0.0005431133,0.0045836135,0.0023504572,0.000059076745,0.00013415827,0.0007451818,0.000039601546,0.004560452,0.95711964,0.00055147585,0.02925571,0.000057486097],"about_ca_topic_score_codex":0.0008353725,"about_ca_topic_score_gemma":0.002251481,"teacher_disagreement_score":0.0018961122,"about_ca_system_score_codex":0.0004279728,"about_ca_system_score_gemma":0.0004149515,"threshold_uncertainty_score":0.0063431263},"labels":[],"label_agreement":null},{"id":"W2883699765","doi":"10.1016/j.bmcl.2018.07.033","title":"Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Science Council; Ionis Pharmaceuticals; Welch Foundation","keywords":"Frataxin; Small interfering RNA; Gene silencing; Trinucleotide repeat expansion; RNA interference; Chemistry; Oligonucleotide; RNA; Nucleic acid; RNA silencing; Gene expression; Gene knockdown; Cell biology; Ataxia; Decoy; Molecular biology; Gene; Biology; Biochemistry; Iron-binding proteins; Neuroscience","score_opus":0.022737639879395463,"score_gpt":0.24098656683234787,"score_spread":0.2182489269529524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2883699765","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98203087,0.00090465415,0.009853038,0.00028418572,0.00015548899,0.00007332154,0.000783914,0.0002755847,0.0056388974],"genre_scores_gemma":[0.98449683,0.00045248508,0.007351366,0.000100945734,0.000011412101,0.00006956682,0.000655501,0.00004677137,0.006815115],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99986756,0.000023220522,0.00001965966,0.000035150697,0.000031159558,0.000023292805],"domain_scores_gemma":[0.9998987,0.000031244384,0.000026508369,0.00001693474,0.000008835436,0.000017879198],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016131891,0.00028313682,0.00019252318,0.0001619369,0.00013814207,0.00024127075,0.00016715871,0.0003122849,0.003260346],"category_scores_gemma":[0.00015399276,0.00012803492,0.00026820475,0.000109579305,0.000321818,0.00018139249,0.00013940579,0.00058695587,0.0006065397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00002798169,0.0000078010335,0.00003566874,0.000017067092,0.0000031035459,0.000028264778,0.0000035191536,0.000036209924,0.99909353,0.0001229445,0.000032151613,0.0005917251],"study_design_scores_gemma":[0.0000068041,0.00005756648,0.0006557132,0.0000028073391,0.0000066568673,0.0001834048,0.000005705319,0.0004095213,0.99725753,0.00004721014,0.0013644015,0.0000027084773],"about_ca_topic_score_codex":0.0006592143,"about_ca_topic_score_gemma":0.0019141682,"teacher_disagreement_score":0.003260346,"about_ca_system_score_codex":0.000276464,"about_ca_system_score_gemma":0.0003414322,"threshold_uncertainty_score":0.010906935},"labels":[],"label_agreement":null},{"id":"W2889861811","doi":"10.1016/j.bmcl.2018.09.016","title":"Methyl-containing pharmaceuticals: Methylation in drug design","year":2018,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":152,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Drug; Pharmacokinetics; Methylation; Pharmacology; Pharmacodynamics; Drug metabolism; Biological activity; Computational biology; Combinatorial chemistry; In vitro; Biochemistry; Gene; Medicine","score_opus":0.27395406553412716,"score_gpt":0.4918970300860542,"score_spread":0.21794296455192702,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2889861811","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0010269085,0.99307126,0.001971423,0.00055556174,0.0003671069,0.000011968269,0.00003527207,0.000026691107,0.0029339034],"genre_scores_gemma":[0.007963446,0.9867764,0.0014715316,0.0004443865,0.0004372398,0.000017713584,0.00005423474,0.0000051947877,0.0028297387],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998734,0.000027521697,0.000013410996,0.000024426281,0.00004322184,0.000017866523],"domain_scores_gemma":[0.99987745,0.000054754433,0.000028209854,0.000007463662,0.000019780593,0.000012292081],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004805145,0.0007495429,0.0008347836,0.0008289642,0.00016706104,0.0005809607,0.00067349215,0.00077903527,0.002860507],"category_scores_gemma":[0.00041061948,0.0003131008,0.00027982815,0.0010029289,0.00043513192,0.0011421661,0.000827238,0.001205104,0.0015741948],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000103267885,0.00007233813,0.0001551212,0.009016893,0.00008659004,0.00027390328,0.0000633386,0.00097653305,0.013915471,0.010591274,0.015836872,0.9489084],"study_design_scores_gemma":[0.00004002198,0.00027005989,0.00031612607,0.0011393445,0.00009792429,0.000987137,0.000035215846,0.00052046176,0.008985918,0.0051856837,0.9823972,0.000024943618],"about_ca_topic_score_codex":0.00028431026,"about_ca_topic_score_gemma":0.0008122091,"teacher_disagreement_score":0.002860507,"about_ca_system_score_codex":0.00034455647,"about_ca_system_score_gemma":0.00047376513,"threshold_uncertainty_score":0.0095694065},"labels":[],"label_agreement":null},{"id":"W2891801532","doi":"10.1016/j.bmcl.2018.08.023","title":"Corrigendum to “Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings” [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320–2323]","year":2018,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Supramolecular Self-Assembly in Materials","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Chemistry; Agonism; Chemical space; Stereochemistry; Biochemistry; Drug discovery","score_opus":0.021677944307361887,"score_gpt":0.27385892863073413,"score_spread":0.25218098432337227,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2891801532","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00017961164,0.0044896216,0.0007470612,0.03270562,0.9512541,0.000055491757,0.00093101256,0.00048409242,0.009153304],"genre_scores_gemma":[0.012186125,0.026131816,0.0035441043,0.07487194,0.20546994,0.00026175662,0.0047589205,0.0009792345,0.6717962],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99713135,0.00022604558,0.00031959117,0.00048165995,0.0013887173,0.000452581],"domain_scores_gemma":[0.9936271,0.0012561524,0.0004574181,0.00038245638,0.0036762357,0.0006006411],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0020671093,0.00310668,0.0029584104,0.0030190642,0.0041940887,0.002446656,0.004770803,0.007220164,0.16356859],"category_scores_gemma":[0.01369159,0.0016402878,0.0025592598,0.0029306503,0.0017981123,0.0028607599,0.002824236,0.0061718896,0.066557854],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003456699,0.000016685979,0.000030397814,0.00023339878,0.000011730875,0.00024389381,0.000017815843,0.00006648281,0.00040753867,0.000529599,0.9914938,0.006914042],"study_design_scores_gemma":[0.00003186574,0.000046154295,0.0007048923,0.00013048253,0.000037307156,0.00023797095,0.00003960071,0.00023243464,0.0019965628,0.00080352515,0.9956873,0.0000517052],"about_ca_topic_score_codex":0.02032037,"about_ca_topic_score_gemma":0.036311593,"teacher_disagreement_score":0.16356859,"about_ca_system_score_codex":0.0062404484,"about_ca_system_score_gemma":0.0037841292,"threshold_uncertainty_score":0.54719144},"labels":[],"label_agreement":null},{"id":"W2892308425","doi":"10.1016/j.bmcl.2018.09.009","title":"Synthesis of novel mono and bis nitric oxide donors with high cytocompatibility and release activity","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Agence Universitaire de la Francophonie","keywords":"Chemistry; Nitric oxide; Chemical synthesis; In vitro; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.010048083405732228,"score_gpt":0.22492043250140792,"score_spread":0.21487234909567568,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2892308425","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9438953,0.006824941,0.036778055,0.00018431936,0.00020158158,0.00014118217,0.00042805294,0.00018821322,0.011358332],"genre_scores_gemma":[0.97030365,0.0017274402,0.019680059,0.00013486292,0.000022995353,0.000084737,0.00027671733,0.00003082846,0.007738712],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999261,0.000011111379,0.000008117304,0.000020743391,0.000016541891,0.000017428816],"domain_scores_gemma":[0.9999294,0.000011231677,0.000019015384,0.000008269659,0.000013462776,0.000018568995],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021253566,0.00036177746,0.00019270537,0.00015777259,0.00016115964,0.00017725736,0.0003985036,0.00032320747,0.0013197422],"category_scores_gemma":[0.00014955278,0.00013715858,0.00013969574,0.00016267777,0.0001072132,0.0003035676,0.0002453945,0.00030211444,0.0003939132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008933847,0.00004276295,0.00005815228,0.00010539181,0.000007412726,0.000086034284,0.000026042402,0.0001971338,0.9897115,0.0008546703,0.00012402592,0.008697466],"study_design_scores_gemma":[0.000017368859,0.00019847827,0.00023579142,0.0000061348615,0.000014372043,0.00012612897,0.0000065688155,0.00054036203,0.9931902,0.00012429389,0.005531236,0.000009012238],"about_ca_topic_score_codex":0.00019531065,"about_ca_topic_score_gemma":0.0005063984,"teacher_disagreement_score":0.0013197422,"about_ca_system_score_codex":0.00016036344,"about_ca_system_score_gemma":0.00022449683,"threshold_uncertainty_score":0.0044149756},"labels":[],"label_agreement":null},{"id":"W2893699812","doi":"10.1016/j.bmcl.2018.09.031","title":"Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Chung Hua University; Mitacs; Université Laval","keywords":"Chemistry; Allopregnanolone; Neuroactive steroid; Hydroxysteroid dehydrogenase; Steroid; Dehydrogenase; Identification (biology); Pharmacology; Stereochemistry; Biochemistry; Endocrinology; Enzyme; Hormone; Receptor","score_opus":0.00443399412220902,"score_gpt":0.21361571526401946,"score_spread":0.20918172114181044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2893699812","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9897078,0.0031041037,0.002868268,0.00011584192,0.000044952165,0.00007662381,0.000613282,0.00009578771,0.0033733984],"genre_scores_gemma":[0.98960084,0.0021178136,0.002398053,0.000058010635,0.0000139652775,0.000024202709,0.0011528559,0.000022053153,0.004612216],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999368,0.00001037198,0.0000053708945,0.0000099058325,0.00001629426,0.000021255048],"domain_scores_gemma":[0.99992204,0.000019174382,0.000015325892,0.00001072896,0.000013086683,0.000019582028],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012989712,0.0003615778,0.00028277395,0.00036287034,0.00013839337,0.00025982995,0.0002783256,0.00019116317,0.002404478],"category_scores_gemma":[0.00019087504,0.00018991162,0.00030097654,0.00023698682,0.00021450433,0.00014855008,0.00013327696,0.0003398701,0.00047183438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00062083325,0.00013399591,0.00046287288,0.000042464846,0.000016325195,0.00015262603,0.00002236023,0.00025785147,0.99131715,0.00024841668,0.000089801855,0.006635316],"study_design_scores_gemma":[0.00004741966,0.0008687576,0.0015148425,0.0000031133304,0.000027694063,0.0002320572,0.000017715969,0.00030391317,0.9940533,0.000036432295,0.002889347,0.0000053693175],"about_ca_topic_score_codex":0.00083639787,"about_ca_topic_score_gemma":0.0011299375,"teacher_disagreement_score":0.002404478,"about_ca_system_score_codex":0.00021440373,"about_ca_system_score_gemma":0.00022886164,"threshold_uncertainty_score":0.008043766},"labels":[],"label_agreement":null},{"id":"W2898456045","doi":"10.1016/j.bmcl.2018.10.044","title":"Stability and evaluation of siRNAs labeled at the sense strand with a 3′-azobenzene unit","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nuclease; Chemistry; Azobenzene; Gene silencing; Sense (electronics); Small interfering RNA; Stereochemistry; RNA; Gene; Biophysics; Photochemistry; Biochemistry; Organic chemistry; Molecule; Biology","score_opus":0.024626534428778192,"score_gpt":0.25871426728113067,"score_spread":0.2340877328523525,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2898456045","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99334705,0.0006705798,0.0042303163,0.000054932894,0.000025457059,0.000017592136,0.00034561922,0.00005780486,0.0012506258],"genre_scores_gemma":[0.99459076,0.00032220676,0.0020122211,0.00002818802,0.0000081448725,0.000026264905,0.00051633455,0.000033621018,0.002462381],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99974436,0.00005491809,0.000027908638,0.000063394335,0.000064502914,0.000044932745],"domain_scores_gemma":[0.99947196,0.00016335429,0.00009267134,0.000046849746,0.00018948363,0.000035682493],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046728284,0.00021935858,0.00016015822,0.0001849889,0.00027104607,0.00026800664,0.00016950998,0.00024589806,0.001113664],"category_scores_gemma":[0.0006133035,0.00013486731,0.000265989,0.00018142865,0.00025465147,0.00017947458,0.00010460152,0.0002681843,0.00038629607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000630559,0.0000064180194,0.00011294497,0.000009918161,0.0000032963083,0.000009809493,0.000024158695,0.000050561954,0.9992926,0.000027979953,0.000013391593,0.00038586496],"study_design_scores_gemma":[0.0000018442505,0.00008176698,0.0006918381,5.163691e-7,0.000007767391,0.000015113747,0.0000064874544,0.00028574938,0.9986946,0.0000055421015,0.00020606797,0.0000027046776],"about_ca_topic_score_codex":0.0029841778,"about_ca_topic_score_gemma":0.0025220672,"teacher_disagreement_score":0.0029841778,"about_ca_system_score_codex":0.00042862666,"about_ca_system_score_gemma":0.00024762307,"threshold_uncertainty_score":0.005933583},"labels":[],"label_agreement":null},{"id":"W2899034067","doi":"10.1016/j.bmcl.2018.10.052","title":"Vitamin E-inspired multi-scale imaging agent","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor; Brock University","funders":"Ontario Centres of Excellence","keywords":"Chemistry; Scale (ratio); Nanotechnology","score_opus":0.008226217775949077,"score_gpt":0.20983363655083326,"score_spread":0.2016074187748842,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2899034067","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9281142,0.0041963398,0.051706847,0.0004877275,0.00013940921,0.0001095712,0.00035100323,0.0005029817,0.014391941],"genre_scores_gemma":[0.9741212,0.00093879347,0.015980026,0.00021697316,0.000011201499,0.000042747983,0.00013629558,0.00003732533,0.00851547],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999536,0.0000055773185,0.0000021754097,0.00001932066,0.000008522825,0.000010829756],"domain_scores_gemma":[0.99997187,0.0000071432482,0.000006594836,0.0000038094745,0.000004400941,0.000006230001],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000079690566,0.00020854856,0.00012867345,0.00011023758,0.000104061495,0.00026464628,0.00025178934,0.0004945151,0.0011534843],"category_scores_gemma":[0.000086857464,0.00010024986,0.00015714261,0.0000686528,0.00013093362,0.00031423778,0.00025628167,0.00031650628,0.00042870248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003345041,0.000012776206,0.000026409594,0.000032352065,0.0000039594993,0.000038340153,0.000011068786,0.00014614442,0.99638003,0.00037139645,0.00012177424,0.002822243],"study_design_scores_gemma":[0.00000535138,0.000039330203,0.00008845998,0.0000015001654,0.0000051931347,0.000050802268,0.0000052964847,0.0008112216,0.9962903,0.000039120496,0.0026603825,0.0000030038452],"about_ca_topic_score_codex":0.0002377071,"about_ca_topic_score_gemma":0.0003859994,"teacher_disagreement_score":0.0011534843,"about_ca_system_score_codex":0.00024870507,"about_ca_system_score_gemma":0.00008200444,"threshold_uncertainty_score":0.0038588643},"labels":[],"label_agreement":null},{"id":"W2901817431","doi":"10.1016/j.bmcl.2018.11.034","title":"New approaches for the treatment of Alzheimer’s disease","year":2018,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Medical Research Council Canada; Medical Research Council; Eisai; Alzheimer’s Research UK; Wellcome Trust; Francis Crick Institute; Biogen; H. Lundbeck A/S; Cancer Research UK; Amgen","keywords":"Disease; Neuroinflammation; Clinical trial; Alzheimer's disease; Cognitive decline; Intensive care medicine; Medicine; Dementia; Internal medicine","score_opus":0.14831373381763982,"score_gpt":0.35927030147046846,"score_spread":0.21095656765282864,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2901817431","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00016151307,0.99789387,0.00027168874,0.00026489567,0.00023300218,0.000007929024,0.000018965295,0.000010325589,0.0011377891],"genre_scores_gemma":[0.0010869299,0.9975278,0.00032003244,0.00019248617,0.00014991495,0.0000076223537,0.000026231157,0.0000014012215,0.00068773306],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99984896,0.000024081237,0.000018057286,0.00002222879,0.00006390103,0.000022855957],"domain_scores_gemma":[0.99982435,0.00007520484,0.000030208215,0.000007425935,0.00004362854,0.000019240977],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005165201,0.00090674625,0.0013276278,0.0021595652,0.00031149125,0.0009830082,0.0009284707,0.0008650046,0.00475571],"category_scores_gemma":[0.00046046873,0.00025215597,0.0006189688,0.0014253523,0.0005787365,0.0013163747,0.00077195425,0.0025239273,0.002063743],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010111875,0.0001442478,0.0000970827,0.015392514,0.000115306044,0.00021848817,0.00006990711,0.00031026552,0.004738914,0.0073704473,0.020266782,0.95117486],"study_design_scores_gemma":[0.000049523253,0.00013954208,0.00047546835,0.0022416,0.00013556973,0.00075897865,0.00004661352,0.00008926861,0.0009879721,0.0037462523,0.99130964,0.00001966901],"about_ca_topic_score_codex":0.00082245027,"about_ca_topic_score_gemma":0.0022646678,"teacher_disagreement_score":0.00475571,"about_ca_system_score_codex":0.00047248675,"about_ca_system_score_gemma":0.00077231333,"threshold_uncertainty_score":0.015909433},"labels":[],"label_agreement":null},{"id":"W2903353456","doi":"10.1016/j.bmcl.2018.11.049","title":"Synthesis and antitumor activity of biotinylated camptothecin derivatives as potent cytotoxic agents","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lakehead University","funders":"","keywords":"Camptothecin; Chemistry; Cytotoxicity; Biotinylation; IC50; Stereochemistry; Structure–activity relationship; Chemical synthesis; Combinatorial chemistry; In vitro; Click chemistry; Biochemistry","score_opus":0.01230031635978984,"score_gpt":0.2512578594633282,"score_spread":0.23895754310353834,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2903353456","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9833946,0.0023372327,0.0062614973,0.00021891067,0.000050966235,0.000110084235,0.00048954884,0.000121155725,0.007015956],"genre_scores_gemma":[0.9909244,0.001110986,0.0032580658,0.00003935325,0.000009175932,0.000039342634,0.0004430823,0.00002182542,0.0041537206],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999281,0.000009784927,0.000005308468,0.000010667057,0.00002091829,0.000025169813],"domain_scores_gemma":[0.99993074,0.000013233271,0.000012459982,0.000007936999,0.000013393169,0.000022191993],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009121453,0.00025305164,0.00014791913,0.00014697292,0.00016404838,0.00021746747,0.0002958812,0.00024152693,0.0017384198],"category_scores_gemma":[0.00015910005,0.00013216089,0.000098183256,0.00020687368,0.00017203383,0.00018493633,0.00011051408,0.0004631156,0.00036631478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027627882,0.000049627637,0.000056467106,0.000045667784,0.000004133986,0.000095377116,0.000028859062,0.00076088274,0.9944522,0.0006901575,0.00014164859,0.003398623],"study_design_scores_gemma":[0.000026190013,0.00018366806,0.00019650304,0.000002720367,0.000005654553,0.000055451343,0.000006256322,0.00061034743,0.9966871,0.00004397796,0.0021784068,0.0000037119062],"about_ca_topic_score_codex":0.0022093556,"about_ca_topic_score_gemma":0.0025168208,"teacher_disagreement_score":0.0022093556,"about_ca_system_score_codex":0.0005882277,"about_ca_system_score_gemma":0.00042188287,"threshold_uncertainty_score":0.005815625},"labels":[],"label_agreement":null},{"id":"W2906540515","doi":"10.1016/j.bmcl.2018.12.054","title":"Synthesis of 1′,2′-methano-2′,3′-dideoxynucleosides as potential antivirals","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Phosphoramidate; Cytidine; Furanose; Nucleoside; Nucleotide; Stereochemistry; Uridine; Prodrug; Nucleoside analogue; Context (archaeology); Ring (chemistry); Biochemistry; RNA; Biology","score_opus":0.015464167207154182,"score_gpt":0.2893813219475335,"score_spread":0.27391715474037936,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2906540515","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87634706,0.025670044,0.050512087,0.001041706,0.00086989073,0.00052313716,0.0023381033,0.00049215107,0.042205725],"genre_scores_gemma":[0.9650243,0.0067276736,0.018134853,0.00021837308,0.00005456022,0.00021096444,0.00067104684,0.000046737576,0.008911483],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998585,0.000028858902,0.00001517198,0.000025214282,0.000018642004,0.000053705073],"domain_scores_gemma":[0.9999232,0.000016648639,0.000012060137,0.000012017348,0.000012360025,0.000023649269],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030968705,0.00049715256,0.00042030108,0.00032860183,0.0002966382,0.00028874323,0.00038895907,0.0004404616,0.0028693762],"category_scores_gemma":[0.00021266296,0.00026391508,0.00025547246,0.00024066512,0.00022571851,0.0002802243,0.00028433572,0.00054731884,0.0010384138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035218266,0.00009922993,0.00025429716,0.0006594149,0.000028806013,0.0007319007,0.00022497769,0.0020005421,0.9662082,0.005774008,0.00058239547,0.023084009],"study_design_scores_gemma":[0.00008352881,0.00080892723,0.00045852584,0.000041469255,0.000031410415,0.0003718892,0.00004507494,0.00086499786,0.97024035,0.0008157092,0.026210688,0.000027418027],"about_ca_topic_score_codex":0.00029812552,"about_ca_topic_score_gemma":0.0007124922,"teacher_disagreement_score":0.0028693762,"about_ca_system_score_codex":0.00038907496,"about_ca_system_score_gemma":0.00044624304,"threshold_uncertainty_score":0.00959897},"labels":[],"label_agreement":null},{"id":"W2911855642","doi":"10.1016/j.bmcl.2019.01.022","title":"Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"Consejo Nacional de Ciencia y Tecnología; Université de Montréal; Concordia University; Réseau Québécois de Recherche sur les Médicaments; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke","keywords":"Methyltransferase; DNMT1; Chemistry; DNA methylation; Methylation; Epigenetics; Demethylation; Gene silencing; DNA methyltransferase; DNA demethylation; DNA; Molecular biology; Gene; Biochemistry; Gene expression; Biology","score_opus":0.010586979028497904,"score_gpt":0.23664899073319717,"score_spread":0.22606201170469928,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2911855642","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9686009,0.0026111074,0.008089617,0.00024070001,0.000091660506,0.0005440381,0.003902529,0.00027461266,0.015644848],"genre_scores_gemma":[0.9772585,0.0017572131,0.008784268,0.00008872685,0.000018435414,0.00032799473,0.0035096619,0.000047858244,0.008207372],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988365,0.00001258889,0.000015522004,0.000014404673,0.000035703455,0.0000380869],"domain_scores_gemma":[0.9999337,0.000005991293,0.00001163175,0.0000144319465,0.000015860312,0.000018368726],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015466969,0.00043705225,0.00043245728,0.00040793634,0.0002645368,0.00018684437,0.0006373063,0.0003269874,0.0033992121],"category_scores_gemma":[0.00022071575,0.00016885002,0.00030895954,0.0005948237,0.00011696719,0.00023478054,0.00026938,0.0004974422,0.0014947705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007670782,0.0003446114,0.00027903277,0.00023244129,0.00004522232,0.00046436547,0.00006373308,0.001650693,0.96180063,0.00085612416,0.00092446635,0.03257155],"study_design_scores_gemma":[0.00016931444,0.0012232041,0.00076308474,0.000009891997,0.00006022975,0.00028090342,0.000022345404,0.0006327018,0.9857781,0.00014220458,0.010900786,0.000017185199],"about_ca_topic_score_codex":0.0014511207,"about_ca_topic_score_gemma":0.0016377066,"teacher_disagreement_score":0.0033992121,"about_ca_system_score_codex":0.0003254231,"about_ca_system_score_gemma":0.0006721945,"threshold_uncertainty_score":0.011371553},"labels":[],"label_agreement":null},{"id":"W2914439358","doi":"10.1016/j.bmcl.2019.02.014","title":"Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Horizon 2020 Framework Programme; Rigshospitalet","keywords":"Radiosynthesis; Chemistry; Tetrazine; Radiochemistry; In vivo; Pet imaging; Pretargeting; Positron emission tomography; Nuclear medicine; Radioimmunotherapy; Organic chemistry","score_opus":0.013432771296873616,"score_gpt":0.27407158158284806,"score_spread":0.26063881028597446,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2914439358","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95532143,0.0017858136,0.039287135,0.00019642751,0.000048726957,0.00025629433,0.00035028046,0.0002190058,0.002534961],"genre_scores_gemma":[0.95762014,0.0028026593,0.03452283,0.00011734851,0.000027546701,0.00019496062,0.0009855455,0.00010933725,0.0036197528],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983776,0.000053884494,0.000008335489,0.00003449275,0.00002668285,0.00003881632],"domain_scores_gemma":[0.99982053,0.00006386497,0.000035790996,0.000021695172,0.00002969295,0.000028466304],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074296974,0.00051764114,0.00040255813,0.0003322848,0.00012126474,0.0003349769,0.00037327787,0.0007133397,0.0010542927],"category_scores_gemma":[0.0003718332,0.00028947834,0.00021752743,0.00016346923,0.00034476756,0.0003617759,0.00017486201,0.0007946157,0.0003964788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013210867,0.00003594007,0.000052184085,0.000026015527,0.0000044071467,0.00004933848,0.000022227548,0.00016980246,0.99855536,0.00005714959,0.000025087003,0.00087036163],"study_design_scores_gemma":[0.00001462356,0.00089571404,0.0004378032,0.000003426807,0.00002037416,0.00018538584,0.0000091130005,0.00066331885,0.99701357,0.000018425417,0.0007318261,0.0000063836633],"about_ca_topic_score_codex":0.00069646526,"about_ca_topic_score_gemma":0.00062802486,"teacher_disagreement_score":0.0010542927,"about_ca_system_score_codex":0.0002182741,"about_ca_system_score_gemma":0.00023724092,"threshold_uncertainty_score":0.0039292574},"labels":[],"label_agreement":null},{"id":"W2914806043","doi":"10.1016/j.bmcl.2019.01.036","title":"Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; University of Saskatchewan; National Research Council Canada; Canada Foundation for Innovation; U.S. Department of Energy","keywords":"Chemistry; Azetidine; Estrogen receptor; Enantiomer; Estrogen receptor alpha; Stereochemistry; Selective estrogen receptor modulator; Mechanism of action; Biochemistry; Cancer; In vitro; Internal medicine; Breast cancer","score_opus":0.0042671129714217815,"score_gpt":0.21988818555453302,"score_spread":0.21562107258311122,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2914806043","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.984897,0.00093192636,0.005729547,0.000323338,0.00008129093,0.00004396195,0.00030439897,0.0001869054,0.007501573],"genre_scores_gemma":[0.9953863,0.0004349538,0.0022288407,0.000046761805,0.000006286853,0.000019746094,0.00017895314,0.000032052692,0.0016660966],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998202,0.00002713347,0.0000071926574,0.00004799641,0.00005018998,0.00004741639],"domain_scores_gemma":[0.9999001,0.000034872235,0.000016487786,0.000014551461,0.0000119189135,0.000022060696],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667926,0.0004228026,0.0005204478,0.00016670108,0.0004845439,0.0010984071,0.0008194892,0.00037445078,0.0038817062],"category_scores_gemma":[0.0005198477,0.00036275343,0.00018426888,0.00021069114,0.00036509839,0.0004311545,0.00053922774,0.0010687109,0.0005785622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001117844,0.00043901347,0.001641879,0.00033107426,0.00009853529,0.0012953517,0.0002140192,0.019929841,0.93860716,0.018470779,0.0027613738,0.015093027],"study_design_scores_gemma":[0.00040743148,0.0006316012,0.0010742586,0.000021807911,0.00010588916,0.00053295016,0.00021576145,0.03838447,0.945971,0.0016072909,0.010974919,0.00007259058],"about_ca_topic_score_codex":0.0024096787,"about_ca_topic_score_gemma":0.0036584246,"teacher_disagreement_score":0.0038817062,"about_ca_system_score_codex":0.00072104763,"about_ca_system_score_gemma":0.0005694803,"threshold_uncertainty_score":0.0129855275},"labels":[],"label_agreement":null},{"id":"W2924877407","doi":"10.1016/j.bmcl.2019.03.033","title":"Synthesis of α-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Wittig reaction; Chemistry; Phosphonium; Bioisostere; Ketone; Bromide; Chemical synthesis; Aromatase; Aryl; Regioselectivity; Combinatorial chemistry; Aqueous solution; Organic chemistry; Alkyl; In vitro; Biochemistry; Catalysis","score_opus":0.04580518413123545,"score_gpt":0.2933587388505057,"score_spread":0.2475535547192702,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2924877407","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9089766,0.010815553,0.05693588,0.00057811954,0.00017604692,0.00038496562,0.0014008546,0.000491157,0.020240806],"genre_scores_gemma":[0.9738454,0.006555054,0.011285194,0.000108930566,0.000034986653,0.00008156453,0.0005377156,0.00002865938,0.007522634],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988115,0.000017394474,0.000014066245,0.000018339719,0.000030847692,0.00003812147],"domain_scores_gemma":[0.99994636,0.000010375957,0.000015839985,0.000007353853,0.000008728553,0.00001133838],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003007488,0.0004264572,0.00024773594,0.000270266,0.00016952647,0.00022822036,0.0003423202,0.00029575685,0.0019824083],"category_scores_gemma":[0.00021392792,0.00021769402,0.00028392585,0.00035586598,0.0001683515,0.0003447467,0.0002518986,0.0004924538,0.00062738685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019094214,0.00011066408,0.00011697533,0.00019089099,0.00002821319,0.00040142093,0.00009847934,0.0007455211,0.9807896,0.0016469907,0.00036835592,0.015312068],"study_design_scores_gemma":[0.000036700156,0.0007575326,0.0003784704,0.0000072826465,0.000018856146,0.00028027108,0.000015984164,0.00051181903,0.9897787,0.00014157007,0.008062697,0.000010151175],"about_ca_topic_score_codex":0.0003735883,"about_ca_topic_score_gemma":0.0010576753,"teacher_disagreement_score":0.0019824083,"about_ca_system_score_codex":0.00023997271,"about_ca_system_score_gemma":0.00035298555,"threshold_uncertainty_score":0.006631851},"labels":[],"label_agreement":null},{"id":"W2942264269","doi":"10.1016/j.bmcl.2019.04.040","title":"Synthesis and preclinical evaluation of [18F]FSL25.1188, a reversible PET radioligand for monoamine oxidase-B","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Aging","keywords":"Radioligand; Monoamine oxidase B; Chemistry; Monoamine oxidase A; Positron emission tomography; Monoamine oxidase; In vivo; Human brain; Radioligand Assay; Ex vivo; Pharmacology; Nuclear medicine; Biochemistry; Enzyme; Receptor; In vitro; Medicine; Neuroscience; Psychology; Biology","score_opus":0.030710971176184678,"score_gpt":0.29475002158925023,"score_spread":0.2640390504130656,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2942264269","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8758087,0.01367884,0.072675735,0.0016631049,0.00058139395,0.005182797,0.0084924055,0.0012135203,0.020703409],"genre_scores_gemma":[0.9347587,0.006457814,0.031109212,0.00047101936,0.00012531961,0.0011677403,0.005985839,0.00013536151,0.019789029],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998611,0.000024926536,0.00001000551,0.000034232307,0.000025172545,0.000044594064],"domain_scores_gemma":[0.9998902,0.000010496225,0.000023905215,0.00001899336,0.000019051158,0.00003724512],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044393115,0.00090816384,0.00045969314,0.0005229045,0.00046613728,0.00037524017,0.0011039543,0.00079621,0.0034642057],"category_scores_gemma":[0.0002654643,0.00058792415,0.0004336102,0.00029245016,0.0003226462,0.00051864644,0.00021388917,0.00087453687,0.0017626651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012616648,0.0007898135,0.00012075436,0.00027230382,0.00006039063,0.0004809041,0.00008540095,0.0013949344,0.969327,0.0011595924,0.0021808555,0.022866342],"study_design_scores_gemma":[0.0012135865,0.009699455,0.00076863734,0.000032527114,0.00020098696,0.0012526527,0.000038517213,0.0019670743,0.9452856,0.00023449807,0.039252885,0.000053448217],"about_ca_topic_score_codex":0.0024090735,"about_ca_topic_score_gemma":0.0035221195,"teacher_disagreement_score":0.0034642057,"about_ca_system_score_codex":0.0005997693,"about_ca_system_score_gemma":0.0009999998,"threshold_uncertainty_score":0.0115888715},"labels":[],"label_agreement":null},{"id":"W2945906071","doi":"10.1016/j.bmcl.2019.05.032","title":"Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TC Scientific (Canada)","funders":"National Institutes of Health; Ministry of Education, India; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Ministry of Earth Sciences","keywords":"TRAF2; Kinase; Context (archaeology); Small molecule; In silico; Chemistry; Cell biology; Computational biology; Cancer research; Biology; Biochemistry; Gene; Receptor","score_opus":0.005079186828949344,"score_gpt":0.20980534846051058,"score_spread":0.20472616163156124,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2945906071","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.6244295,0.04100335,0.2729679,0.0034675044,0.0010011959,0.0019573565,0.0073258136,0.0034054476,0.044441953],"genre_scores_gemma":[0.87514484,0.01852095,0.07957985,0.001130091,0.00015325643,0.0014132796,0.005895703,0.00019038052,0.017971583],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9991223,0.00012900053,0.000047710993,0.00012435841,0.0004118874,0.0001647478],"domain_scores_gemma":[0.99953127,0.000119384305,0.00009381106,0.00007325451,0.00010400112,0.00007829212],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012346391,0.001705794,0.00064153713,0.00091104035,0.00060440425,0.0012427777,0.0011857371,0.0010771028,0.003569254],"category_scores_gemma":[0.0007945233,0.00046571487,0.0005646408,0.0007088995,0.0006242284,0.00083427026,0.0007691562,0.0021593014,0.0012797907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002837112,0.00020394419,0.00043023462,0.00026155007,0.000046846228,0.00009787141,0.000038439226,0.0009282177,0.985407,0.002615053,0.0009093503,0.008777778],"study_design_scores_gemma":[0.000081575854,0.00042035346,0.0005136355,0.00001715352,0.000036181358,0.00030409312,0.000026170364,0.0016927196,0.9861667,0.0006864713,0.010035006,0.000019896115],"about_ca_topic_score_codex":0.00092783576,"about_ca_topic_score_gemma":0.0022452148,"teacher_disagreement_score":0.003569254,"about_ca_system_score_codex":0.0013099799,"about_ca_system_score_gemma":0.00096030073,"threshold_uncertainty_score":0.0119403},"labels":[],"label_agreement":null},{"id":"W2949216246","doi":"10.1016/j.bmcl.2005.11.009","title":"Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"Pyrimidinones; Chemistry; Staphylococcus aureus; Polymerase; DNA polymerase; Nucleobase; DNA; Bacteria; Antibacterial agent; DNA replication; Antibacterial activity; In vitro; Biochemistry; Microbiology; Stereochemistry; Antibiotics; Biology; Genetics","score_opus":0.010115776203997878,"score_gpt":0.2480739784020463,"score_spread":0.23795820219804845,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2949216246","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8941283,0.051134396,0.02190821,0.00076378504,0.0009958139,0.00070099684,0.0009917236,0.0008775807,0.028499112],"genre_scores_gemma":[0.9622983,0.01555428,0.007644068,0.0004861011,0.00014874317,0.00020640588,0.0010388489,0.00007398573,0.012549363],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985087,0.000023303659,0.000010817765,0.000026849348,0.00003818814,0.000049972776],"domain_scores_gemma":[0.9999013,0.00002527326,0.000018580962,0.0000075527723,0.000015971937,0.000031271502],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024149744,0.0007289182,0.0007057872,0.00043302946,0.00028535983,0.00048180882,0.0006938815,0.00043056303,0.0025582244],"category_scores_gemma":[0.00028295704,0.0003135734,0.00031792256,0.00020025657,0.00018925886,0.00020770953,0.0003368142,0.00086817204,0.00085994345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001177586,0.0004541698,0.00041871017,0.0004324077,0.00009637077,0.0006141203,0.00011041843,0.001861811,0.93681794,0.0015809931,0.0015703437,0.05486514],"study_design_scores_gemma":[0.0008475663,0.004066916,0.001918972,0.00007557907,0.00012168734,0.0015428457,0.000040606858,0.0047144173,0.95162004,0.0003902147,0.034616318,0.000044734174],"about_ca_topic_score_codex":0.00089997106,"about_ca_topic_score_gemma":0.0025420382,"teacher_disagreement_score":0.0025582244,"about_ca_system_score_codex":0.00045943903,"about_ca_system_score_gemma":0.00029579265,"threshold_uncertainty_score":0.008558154},"labels":[],"label_agreement":null},{"id":"W2949243570","doi":"10.1016/j.bmcl.2006.05.015","title":"7-(Aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: Addition of water solubilizing groups","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Dimethylamine; Aryl; Alkoxy group; Stereochemistry; Thiophene; Pyridine; Chemical synthesis; Carboxamide; Nitro; Enzyme inhibitor; Proto-oncogene tyrosine-protein kinase Src; Kinase; Ring (chemistry); Medicinal chemistry; Enzyme; Organic chemistry; In vitro; Biochemistry","score_opus":0.007205454049731535,"score_gpt":0.20108357520267803,"score_spread":0.1938781211529465,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2949243570","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95517254,0.011742077,0.017601069,0.00027984421,0.00015056018,0.00017853003,0.00027057575,0.00038226738,0.014222597],"genre_scores_gemma":[0.9845606,0.00445512,0.004598588,0.00008727573,0.000033627322,0.00008874292,0.00018544022,0.000023964481,0.005966609],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991536,0.000019892808,0.0000045885204,0.0000125747465,0.000017807446,0.00002982843],"domain_scores_gemma":[0.9999653,0.000008690545,0.000010368942,0.0000033615293,0.000005483421,0.0000067721603],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025296648,0.0003123334,0.00022818794,0.00020463039,0.0001313344,0.00014614839,0.0004143175,0.00026632115,0.0016928932],"category_scores_gemma":[0.0000895655,0.00014638717,0.00015529436,0.00009879069,0.00016019808,0.0002626667,0.00021196903,0.00030914252,0.0005092407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025316712,0.000075814874,0.00008987703,0.00013604654,0.000008709132,0.00023627086,0.000053403506,0.0004651622,0.9871279,0.0015328022,0.00027276273,0.009748117],"study_design_scores_gemma":[0.0001347895,0.0012387083,0.0011896805,0.000014317779,0.000023782552,0.00039638646,0.000024657384,0.0014645362,0.9836166,0.00016921377,0.01170918,0.000018074083],"about_ca_topic_score_codex":0.00026054267,"about_ca_topic_score_gemma":0.000591833,"teacher_disagreement_score":0.0016928932,"about_ca_system_score_codex":0.0001766218,"about_ca_system_score_gemma":0.00014452904,"threshold_uncertainty_score":0.0056632757},"labels":[],"label_agreement":null},{"id":"W2949402964","doi":"10.1016/j.bmcl.2008.05.071","title":"Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A novel class of 5-lipoxygenase inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Structural isomer; Moiety; Stereochemistry; Pharmacophore; Acetylene; Lipoxygenase; Organic chemistry; Enzyme","score_opus":0.05553899407804506,"score_gpt":0.2561923955846499,"score_spread":0.20065340150660485,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2949402964","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9713319,0.0095071355,0.01104163,0.00020187281,0.00007871742,0.00034475373,0.0011445325,0.0001730305,0.0061763627],"genre_scores_gemma":[0.9840127,0.0052783764,0.005490797,0.000092124974,0.000033900356,0.00015733445,0.0010250537,0.000022291671,0.0038874142],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985933,0.000038744703,0.000014067575,0.000022146814,0.000027106495,0.000038677772],"domain_scores_gemma":[0.99992037,0.000011294691,0.00002144967,0.000011096913,0.000015542693,0.000020326004],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002893357,0.0004206919,0.00030044073,0.00028781948,0.00017886997,0.00016629133,0.00036779372,0.00027741666,0.0015305054],"category_scores_gemma":[0.00016392421,0.00019626292,0.00029039138,0.0002025875,0.0001484402,0.00020804648,0.00015789554,0.0003212607,0.00056562654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005371009,0.0002116379,0.00015417865,0.000093972696,0.000017694134,0.00013566377,0.000044542052,0.0006518741,0.9883917,0.00034078618,0.00016513938,0.009255745],"study_design_scores_gemma":[0.0001427815,0.0027673703,0.0014261806,0.000008573354,0.0000443841,0.00029522864,0.000019667357,0.00047391397,0.9895112,0.000040011324,0.0052590687,0.000011679203],"about_ca_topic_score_codex":0.0005527547,"about_ca_topic_score_gemma":0.0012325629,"teacher_disagreement_score":0.0015305054,"about_ca_system_score_codex":0.00021457141,"about_ca_system_score_gemma":0.0003072942,"threshold_uncertainty_score":0.005120039},"labels":[],"label_agreement":null},{"id":"W2949931127","doi":"10.1016/j.bmcl.2014.03.069","title":"Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Strecker amino acid synthesis; Wittig reaction; Staudinger reaction; Nitrile; Stereoselectivity; Yield (engineering); Xylose; Stereochemistry; Enantioselective synthesis; Organic chemistry; Catalysis","score_opus":0.013940869006596619,"score_gpt":0.2112590752900092,"score_spread":0.1973182062834126,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2949931127","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.67525506,0.012047955,0.22965606,0.0015857812,0.0011393825,0.0017700194,0.0026859222,0.004080889,0.07177896],"genre_scores_gemma":[0.90875435,0.0077592554,0.06449225,0.0003987943,0.00014563622,0.00068906264,0.0011729978,0.00025247937,0.016335238],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9996512,0.000048766513,0.000036407164,0.00006596762,0.00008118754,0.000116434836],"domain_scores_gemma":[0.999905,0.000014892677,0.00002152752,0.00001612878,0.000015190334,0.000027272],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006242126,0.0014810757,0.0007630508,0.0006044394,0.0005383516,0.00041915794,0.0012391083,0.00069445936,0.002370334],"category_scores_gemma":[0.00031116031,0.00047895627,0.00048324224,0.00058491435,0.00042245732,0.0008449515,0.0009015511,0.001340743,0.0022317246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047937594,0.0005911559,0.00030775002,0.0011046573,0.00016417638,0.0026770432,0.0008658054,0.007052296,0.87246674,0.018935967,0.006736774,0.08861828],"study_design_scores_gemma":[0.00019083625,0.0017804976,0.0008110482,0.0000540061,0.00009721321,0.00086705905,0.000084326944,0.005866558,0.9380601,0.0023658026,0.04968781,0.0001347907],"about_ca_topic_score_codex":0.00095435523,"about_ca_topic_score_gemma":0.0019030075,"teacher_disagreement_score":0.002370334,"about_ca_system_score_codex":0.00074298313,"about_ca_system_score_gemma":0.00082177453,"threshold_uncertainty_score":0.0079295635},"labels":[],"label_agreement":null},{"id":"W2950360708","doi":"10.1016/j.bmcl.2006.05.005","title":"Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: Novel classes of histone deacetylase inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Acetylation; Histone deacetylase; Chemistry; Histone; In vitro; Cell growth; Cancer cell; HDAC11; Histone deacetylase 5; Enzyme; Cancer research; HDAC1; Cell cycle; Biochemistry; Cancer; Apoptosis; Biology; Internal medicine; Gene; Medicine","score_opus":0.009023453301456253,"score_gpt":0.2515959901929952,"score_spread":0.24257253689153896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2950360708","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8393166,0.06932953,0.035584986,0.00096006825,0.0008502035,0.00032484217,0.0006745683,0.0009630866,0.051996067],"genre_scores_gemma":[0.9546074,0.019949466,0.010456601,0.00037491476,0.00019034576,0.00019556582,0.00038408278,0.000039437866,0.0138022],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99988294,0.000026228774,0.000008345299,0.000019106477,0.000029349298,0.00003399173],"domain_scores_gemma":[0.99992824,0.000011157349,0.000025401287,0.0000056837066,0.000009809642,0.00001974123],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020863528,0.0003482319,0.0002893655,0.00022444889,0.00016079094,0.000248148,0.000498572,0.00032302726,0.0022525522],"category_scores_gemma":[0.00016175989,0.0001754902,0.0001438316,0.00017979727,0.00022755591,0.00035049723,0.0001804339,0.0004957585,0.00071593584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00056066556,0.00016352578,0.00009512812,0.00029220514,0.000016309226,0.000265013,0.000057902293,0.00079798704,0.967431,0.0038967058,0.00086944894,0.025554014],"study_design_scores_gemma":[0.000303959,0.00288785,0.0019475139,0.00003286541,0.00004023507,0.0010132532,0.000041077026,0.0019102274,0.94647574,0.0004884272,0.044818513,0.000040318],"about_ca_topic_score_codex":0.00038379544,"about_ca_topic_score_gemma":0.0008233633,"teacher_disagreement_score":0.0022525522,"about_ca_system_score_codex":0.00027684594,"about_ca_system_score_gemma":0.00023639284,"threshold_uncertainty_score":0.007535517},"labels":[],"label_agreement":null},{"id":"W2950651198","doi":"10.1016/j.bmcl.2004.05.087","title":"Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Potency; Stereochemistry; Moiety; Cathepsin K; Aryl; Selectivity; Structure–activity relationship; Thiophene; Chemical synthesis; Cathepsin; Linker; In vitro; Biochemistry; Enzyme","score_opus":0.009059369093885586,"score_gpt":0.20742563415903523,"score_spread":0.19836626506514965,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2950651198","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.917862,0.009865296,0.053152647,0.0006696639,0.00017405703,0.0005989225,0.0010457014,0.0006353743,0.015996205],"genre_scores_gemma":[0.97201926,0.0058939043,0.01646644,0.00018160122,0.000026808952,0.00013250066,0.0005977609,0.000037307895,0.004644411],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99987626,0.000017078706,0.0000129275595,0.000019018888,0.000036814305,0.000037953476],"domain_scores_gemma":[0.9999523,0.000006841929,0.00001642618,0.0000043509945,0.0000085512775,0.000011419457],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002882833,0.00044574967,0.00044710955,0.00020806633,0.00018041291,0.00047985173,0.00061090983,0.00025238108,0.0012881721],"category_scores_gemma":[0.000189998,0.0002419014,0.00023729204,0.0001974695,0.00022250523,0.00031015894,0.0003131647,0.0005667404,0.000513041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001081584,0.00054984936,0.00073604006,0.000568912,0.000111701316,0.0008371314,0.00011521546,0.018269762,0.9175535,0.0074356776,0.0021499014,0.050590724],"study_design_scores_gemma":[0.00089699397,0.0025110377,0.0010061834,0.000045820958,0.00017075022,0.00092888833,0.00007924162,0.025400747,0.9357895,0.0012858169,0.03182365,0.00006121963],"about_ca_topic_score_codex":0.0006047376,"about_ca_topic_score_gemma":0.002687423,"teacher_disagreement_score":0.0012881721,"about_ca_system_score_codex":0.00050273933,"about_ca_system_score_gemma":0.0003953145,"threshold_uncertainty_score":0.004309356},"labels":[],"label_agreement":null},{"id":"W2950902233","doi":"10.1016/j.bmcl.2005.08.007","title":"(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Vasopressin; Arginine; Stereochemistry; Amide; Chemical synthesis; Vasopressin receptor; Receptor; Linkage (software); Structure–activity relationship; Carboxamide; In vitro; Amino acid; Biochemistry; Endocrinology; Gene","score_opus":0.018456190762702072,"score_gpt":0.29591148891820984,"score_spread":0.2774552981555078,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2950902233","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9409726,0.028057283,0.0070996364,0.000740423,0.00054056844,0.000088309054,0.0005852873,0.00029486787,0.021620963],"genre_scores_gemma":[0.97690976,0.01004916,0.0029959716,0.00022475445,0.00007845356,0.00005260772,0.00021518272,0.000015169282,0.009458821],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994814,0.000015221255,0.0000030856745,0.000006577796,0.000008002593,0.00001894753],"domain_scores_gemma":[0.9999665,0.00000735438,0.000008545928,0.0000028709014,0.0000036862682,0.000010990878],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013119246,0.0001887762,0.0002111585,0.0001335771,0.00013989555,0.0001481773,0.00030170914,0.00019669472,0.0035309454],"category_scores_gemma":[0.00010576135,0.00009654275,0.00009089318,0.00015176233,0.00016908204,0.00021919092,0.00016072257,0.00034788402,0.00069131085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015339294,0.00018019212,0.00042904427,0.0004559089,0.000024604282,0.0006480612,0.00017441268,0.0010123409,0.9560492,0.004638226,0.0014269244,0.033427168],"study_design_scores_gemma":[0.00091347465,0.0064716856,0.0067940345,0.000083423,0.00009374046,0.0022337774,0.0001753194,0.0029386987,0.9035711,0.00089592166,0.07576193,0.00006680322],"about_ca_topic_score_codex":0.00033976597,"about_ca_topic_score_gemma":0.0010931742,"teacher_disagreement_score":0.0035309454,"about_ca_system_score_codex":0.00020926424,"about_ca_system_score_gemma":0.00015030289,"threshold_uncertainty_score":0.01181221},"labels":[],"label_agreement":null},{"id":"W2951099321","doi":"10.1016/j.bmcl.2009.09.011","title":"Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nevirapine; Chemistry; Click chemistry; Azide; Triazole; Pharmacokinetics; Combinatorial chemistry; Chemical synthesis; Human immunodeficiency virus (HIV); Pharmacology; Stereochemistry; Biochemistry; Organic chemistry; In vitro; Antiretroviral therapy; Virology","score_opus":0.011617764539061295,"score_gpt":0.24926300214436814,"score_spread":0.23764523760530684,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2951099321","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98484105,0.0018215935,0.0076232953,0.00009773305,0.000025054747,0.00012155433,0.0005015671,0.00009028104,0.004877911],"genre_scores_gemma":[0.991711,0.0010033281,0.004310263,0.000033396733,0.000005557895,0.00004371185,0.0003167367,0.000014540612,0.0025614148],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999329,0.000011899905,0.0000036228203,0.00001233572,0.000023295283,0.000016007254],"domain_scores_gemma":[0.9999515,0.000013519221,0.00001278459,0.0000059863846,0.000007012877,0.000009264867],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011886966,0.00023220302,0.00021005848,0.00013037423,0.00010954587,0.0001970636,0.00015351246,0.00021830242,0.0009391624],"category_scores_gemma":[0.00016768505,0.00009933121,0.00019004964,0.0001240115,0.000072442686,0.00020124983,0.000120516146,0.00042506043,0.00018853732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017050064,0.000059955444,0.00019628098,0.000047831472,0.000013823419,0.00016463197,0.0000223751,0.0007955572,0.991548,0.00030026192,0.000112940106,0.006567897],"study_design_scores_gemma":[0.000022997943,0.00036729377,0.00076433073,0.0000024169826,0.0000132553005,0.00013465152,0.0000092245255,0.0020286557,0.9948278,0.000043417345,0.0017769467,0.000009003057],"about_ca_topic_score_codex":0.0008332907,"about_ca_topic_score_gemma":0.0017529484,"teacher_disagreement_score":0.0009391624,"about_ca_system_score_codex":0.0002304887,"about_ca_system_score_gemma":0.00016458798,"threshold_uncertainty_score":0.0031418204},"labels":[],"label_agreement":null},{"id":"W2951117274","doi":"10.1016/j.bmcl.2004.08.032","title":"Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Chemistry; Piperidine; Stereochemistry; Chemical synthesis; Receptor; Structure–activity relationship; Agonist; Combinatorial chemistry; In vitro; Biochemistry","score_opus":0.02046480351347529,"score_gpt":0.22042076054951718,"score_spread":0.19995595703604188,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2951117274","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.905726,0.012048058,0.056717984,0.00094639324,0.0004475528,0.00081754336,0.0011660252,0.00048662958,0.021643817],"genre_scores_gemma":[0.946571,0.00831738,0.03207885,0.00035599346,0.00008470873,0.000310968,0.000735832,0.0000468591,0.011498357],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992895,0.000010321772,0.0000070072374,0.000012578132,0.000011280106,0.00002984497],"domain_scores_gemma":[0.999946,0.0000066144426,0.000017822653,0.00000433207,0.00000978317,0.000015411413],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018259978,0.00045111537,0.0003134619,0.00021270658,0.00018224267,0.00023320434,0.0005370708,0.00028633466,0.0035574278],"category_scores_gemma":[0.00015135753,0.0002361671,0.00020431803,0.00018685238,0.00015913982,0.00029771766,0.00023497961,0.0005918914,0.0008579137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004892118,0.00017281812,0.00010834946,0.00052347983,0.000018761259,0.0005301049,0.00010952153,0.0021942945,0.96007246,0.002712542,0.0007359133,0.032332625],"study_design_scores_gemma":[0.00040777982,0.0045189983,0.0008028699,0.00005063181,0.000055292992,0.00055089715,0.000056946043,0.003344416,0.96148217,0.00046303717,0.028228087,0.00003893217],"about_ca_topic_score_codex":0.00038328025,"about_ca_topic_score_gemma":0.001097698,"teacher_disagreement_score":0.0035574278,"about_ca_system_score_codex":0.00029215947,"about_ca_system_score_gemma":0.00034305805,"threshold_uncertainty_score":0.011900723},"labels":[],"label_agreement":null},{"id":"W2951555034","doi":"10.1016/j.bmcl.2004.02.035","title":"Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitriles","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Sonogashira coupling; Stille reaction; Proto-oncogene tyrosine-protein kinase Src; Stereochemistry; Chemical synthesis; Enzyme inhibitor; Enzyme; Kinase; Biochemistry; In vitro; Palladium; Catalysis","score_opus":0.006461414666345073,"score_gpt":0.21096296786955732,"score_spread":0.20450155320321226,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2951555034","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97383434,0.0030886068,0.013256212,0.00026620188,0.00012051055,0.00012513893,0.00043995967,0.00024317902,0.008625826],"genre_scores_gemma":[0.9927979,0.0009516244,0.0026155477,0.00004920797,0.000021989796,0.000055542918,0.00039897842,0.000029813798,0.0030794065],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998247,0.000029937206,0.00001460259,0.000024537647,0.00003784692,0.00006826793],"domain_scores_gemma":[0.99983776,0.00003976252,0.000049159145,0.000025566576,0.000019541296,0.000028218958],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038429664,0.00037468987,0.00021202439,0.00021774156,0.00016652331,0.00020853762,0.00052363164,0.00038617715,0.0017074414],"category_scores_gemma":[0.0002116574,0.00017066029,0.00034087765,0.00010631933,0.00021963673,0.00025862386,0.00020830751,0.0005101677,0.00051429245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003041729,0.00006372364,0.00007126099,0.000052971925,0.000009605913,0.00018826335,0.000027382424,0.0004279547,0.9946068,0.001175687,0.00011080221,0.0029614582],"study_design_scores_gemma":[0.000047248184,0.00041610378,0.0004627833,0.0000033570427,0.000009101365,0.0001514986,0.0000070998744,0.00047501284,0.9966127,0.00007137672,0.0017365972,0.000006984504],"about_ca_topic_score_codex":0.00037777203,"about_ca_topic_score_gemma":0.0004965693,"teacher_disagreement_score":0.0017074414,"about_ca_system_score_codex":0.00027430346,"about_ca_system_score_gemma":0.00032614524,"threshold_uncertainty_score":0.005711913},"labels":[],"label_agreement":null},{"id":"W2952025816","doi":"10.1016/j.bmcl.2003.11.083","title":"Design and synthesis of novel small molecule N/OFQ receptor antagonists","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Chemistry; Receptor; Stereochemistry; Small molecule; Molecule; Nociceptin receptor; Biophysics; Biochemistry","score_opus":0.03173037602786755,"score_gpt":0.2286201623985343,"score_spread":0.19688978637066676,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952025816","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8089262,0.018616214,0.14642718,0.0017956689,0.00090426585,0.0022185214,0.0016728259,0.00078411354,0.018654972],"genre_scores_gemma":[0.8705511,0.018892203,0.085327365,0.0009793208,0.00020039931,0.0010315992,0.0021133428,0.0001384841,0.020766227],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998907,0.000014823176,0.000011779358,0.000019936228,0.000023747714,0.00003905353],"domain_scores_gemma":[0.9999454,0.000007822098,0.000012596922,0.0000048738434,0.00001075913,0.000018579936],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003333668,0.0005029279,0.0005844978,0.00022643976,0.00032060867,0.00047216416,0.0007396713,0.00044161145,0.0025806415],"category_scores_gemma":[0.00020038741,0.0003482301,0.0003878566,0.00015342189,0.00024373266,0.0003837232,0.00030669157,0.0007916628,0.0008788367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00041119292,0.00016048353,0.00011931481,0.0003172808,0.000046148165,0.00039055911,0.00008663895,0.0017074326,0.970777,0.0037578174,0.0010595631,0.0211667],"study_design_scores_gemma":[0.00084620225,0.0026789093,0.0006456732,0.00005260117,0.00011955503,0.00091520103,0.00007293414,0.005888272,0.915887,0.00090103963,0.07192518,0.00006755934],"about_ca_topic_score_codex":0.00061548036,"about_ca_topic_score_gemma":0.0021302304,"teacher_disagreement_score":0.0025806415,"about_ca_system_score_codex":0.00053574605,"about_ca_system_score_gemma":0.00054215186,"threshold_uncertainty_score":0.008633137},"labels":[],"label_agreement":null},{"id":"W2952266123","doi":"10.1016/j.bmcl.2005.01.004","title":"Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Proto-oncogene tyrosine-protein kinase Src; Enzyme inhibitor; Stereochemistry; Substituent; Kinase; Potency; Enzyme; Biochemistry; In vitro","score_opus":0.013767680266228934,"score_gpt":0.2582510752768935,"score_spread":0.24448339501066457,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952266123","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9790933,0.003288173,0.01204412,0.00025417405,0.000056846235,0.00037190758,0.00027641738,0.000092084185,0.004523026],"genre_scores_gemma":[0.98446566,0.002234577,0.00649027,0.00012243181,0.000029656032,0.00020677783,0.0005543053,0.00004144594,0.0058548097],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981207,0.000049414055,0.0000122282345,0.000023293447,0.000039686412,0.00006323921],"domain_scores_gemma":[0.9997851,0.00009679275,0.000027492828,0.000017408718,0.00004571128,0.000027406257],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006263881,0.00040454604,0.00045783323,0.00020158265,0.00023196248,0.00019184005,0.0004514481,0.0002874287,0.0022263317],"category_scores_gemma":[0.00040205286,0.00012885209,0.00029877972,0.00014779957,0.00027696186,0.00032414155,0.00015395165,0.00051056175,0.0005090645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005522242,0.00015742789,0.00010915501,0.00006632321,0.0000129186365,0.00015053825,0.00006211783,0.00041375725,0.99511695,0.00033609624,0.000077161785,0.0029453437],"study_design_scores_gemma":[0.000111515255,0.0017725814,0.0012040414,0.0000037002471,0.000027360245,0.00027189963,0.000029938508,0.000996366,0.99301857,0.000073661125,0.0024785907,0.00001183553],"about_ca_topic_score_codex":0.0010303176,"about_ca_topic_score_gemma":0.0009342222,"teacher_disagreement_score":0.0022263317,"about_ca_system_score_codex":0.00024539616,"about_ca_system_score_gemma":0.0003383476,"threshold_uncertainty_score":0.007447779},"labels":[],"label_agreement":null},{"id":"W2952394377","doi":"10.1016/j.bmcl.2004.06.013","title":"Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"NS5B; Chemistry; RNA polymerase; Polymerase; Enzyme; RNA; RNA-dependent RNA polymerase; Carboxamide; Naphthalene; Stereochemistry; Biochemistry; Organic chemistry; Hepacivirus; Gene; Genotype","score_opus":0.013781130654171891,"score_gpt":0.27507939770031253,"score_spread":0.2612982670461406,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952394377","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.981459,0.00563944,0.0048879036,0.00014656504,0.00010544379,0.00015733554,0.00036494774,0.00009101715,0.0071482332],"genre_scores_gemma":[0.9894741,0.0025121907,0.0041537844,0.00008138764,0.000029136374,0.000048899197,0.00039599455,0.000018255974,0.003286364],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990296,0.000025525096,0.0000068401882,0.000012338481,0.000026488622,0.000025925994],"domain_scores_gemma":[0.99990654,0.000017641889,0.000018383858,0.000009891815,0.000022165777,0.000025420655],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017609917,0.0002977781,0.0002540946,0.00026744025,0.00016163147,0.00022047787,0.00028741694,0.0002786554,0.0011364395],"category_scores_gemma":[0.00020088289,0.00019465791,0.00018613151,0.0001502112,0.00013094912,0.00017267476,0.00012274807,0.00032894345,0.00033284884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003510501,0.000073558636,0.00014933893,0.000051244333,0.000009171906,0.00010955147,0.000014340755,0.00026644132,0.9937405,0.000204681,0.00006794885,0.004962231],"study_design_scores_gemma":[0.000085255684,0.0011507816,0.0015914073,0.0000075276166,0.000023459921,0.0002104329,0.0000074756917,0.000994788,0.9931611,0.000043062086,0.0027175755,0.000007234035],"about_ca_topic_score_codex":0.0006538311,"about_ca_topic_score_gemma":0.0019001847,"teacher_disagreement_score":0.0011364395,"about_ca_system_score_codex":0.00024762945,"about_ca_system_score_gemma":0.00022288148,"threshold_uncertainty_score":0.0038018227},"labels":[],"label_agreement":null},{"id":"W2952418774","doi":"10.1016/s0960-894x(02)00831-4","title":"3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"National Research Council Canada; NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Proteases; Cysteine; Cathepsin; Cysteine Proteinase Inhibitors; Cysteine protease; Enzyme inhibitor; Cathepsin L; Cathepsin B; Thiol; Lactam; Stereochemistry; Biochemistry; Enzyme","score_opus":0.009884910576139699,"score_gpt":0.2150493268178953,"score_spread":0.2051644162417556,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952418774","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8655155,0.08113069,0.019262604,0.0013773296,0.00082988536,0.00026083586,0.0007065215,0.00083335396,0.030083215],"genre_scores_gemma":[0.95263267,0.02581215,0.008048196,0.0005040685,0.00021660372,0.000118704884,0.00073269877,0.000031164367,0.0119037395],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999212,0.000014917282,0.0000049603045,0.000012906065,0.000020371685,0.000025601797],"domain_scores_gemma":[0.9999757,0.0000028048294,0.0000047048306,0.0000020486234,0.0000044388094,0.000010430611],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015576802,0.000466303,0.0005038247,0.00033908675,0.00021246253,0.00044762724,0.00042380454,0.00044572185,0.00073450635],"category_scores_gemma":[0.00007100972,0.00012707284,0.00018293488,0.00027983933,0.00016442766,0.00029520862,0.00020312305,0.00051649153,0.0004196861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015490977,0.00031122012,0.00042964783,0.00030439207,0.0000469875,0.0012785238,0.00007913048,0.0018240737,0.91817486,0.0051513705,0.0021510466,0.068699636],"study_design_scores_gemma":[0.0008872698,0.004861856,0.004924778,0.000039572715,0.0001384679,0.003918374,0.00003804887,0.0066978694,0.8599244,0.0011464229,0.117363535,0.0000594922],"about_ca_topic_score_codex":0.00042412724,"about_ca_topic_score_gemma":0.0007559136,"teacher_disagreement_score":0.00073450635,"about_ca_system_score_codex":0.0004160435,"about_ca_system_score_gemma":0.00021287598,"threshold_uncertainty_score":0.0030186176},"labels":[],"label_agreement":null},{"id":"W2952424574","doi":"10.1016/j.bmcl.2012.08.042","title":"A new class of pyrimidine nucleosides: inhibitors of hepatitis B and C viruses","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Ribavirin; Pyrimidine; Virology; Hepatitis B virus; Hepatitis C virus; Hepatitis B; Chemistry; Cytotoxicity; Liver cancer; Hepatitis C; Cirrhosis; In vitro; Hepatitis; Nucleoside; Nucleoside analogue; Virus; Biology; Hepatocellular carcinoma; Biochemistry; Medicine; Cancer research; Internal medicine","score_opus":0.024541331655959377,"score_gpt":0.28461061032973983,"score_spread":0.26006927867378044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952424574","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.45192167,0.4037586,0.03207766,0.0051116506,0.0027506063,0.0008649852,0.0026066494,0.0012365257,0.09967164],"genre_scores_gemma":[0.7449985,0.1770376,0.022890322,0.004195829,0.0011541517,0.00046758237,0.0021550427,0.00011259583,0.04698832],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989855,0.0000169524,0.0000060649936,0.000026195363,0.000027081409,0.000025140762],"domain_scores_gemma":[0.9999144,0.00001547328,0.000013273565,0.0000060057987,0.00001532883,0.00003549755],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023979864,0.0004543824,0.00051807944,0.00049982104,0.00036331356,0.0006630882,0.00046889202,0.0005925388,0.0028407087],"category_scores_gemma":[0.00022103712,0.00017679823,0.00027968705,0.00027966758,0.00022426494,0.00048381076,0.00033962395,0.0010306917,0.0010359791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018925265,0.00081605325,0.0010513685,0.0012112781,0.0000935511,0.0011929187,0.00025942587,0.0020015256,0.51347065,0.012126082,0.01671783,0.44916686],"study_design_scores_gemma":[0.0015086624,0.009567911,0.0053444845,0.00026614635,0.00023252293,0.008643698,0.000109196255,0.0042524002,0.30822966,0.0032575426,0.6584703,0.0001175861],"about_ca_topic_score_codex":0.00058299,"about_ca_topic_score_gemma":0.0013051411,"teacher_disagreement_score":0.0028407087,"about_ca_system_score_codex":0.0004085614,"about_ca_system_score_gemma":0.00032443865,"threshold_uncertainty_score":0.009503067},"labels":[],"label_agreement":null},{"id":"W2952503645","doi":"10.1016/j.bmcl.2006.05.061","title":"Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Nitrile; Cathepsin; Cathepsin K; Cysteine protease; Chemical synthesis; Enzyme inhibitor; Stereochemistry; Pharmacology; Cysteine; Combinatorial chemistry; Biochemistry; Enzyme; In vitro; Organic chemistry","score_opus":0.004715731646605631,"score_gpt":0.19152149255134054,"score_spread":0.1868057609047349,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952503645","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91902155,0.010540291,0.05074214,0.0006909937,0.00033513314,0.00092847133,0.0011723726,0.0005677369,0.01600144],"genre_scores_gemma":[0.9678785,0.0057822387,0.017390685,0.00021554095,0.00004346618,0.0002977002,0.0009326054,0.000047618767,0.0074115074],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998754,0.000016460514,0.000014485184,0.000023033761,0.000028890423,0.00004166987],"domain_scores_gemma":[0.99993265,0.0000068507784,0.000023387032,0.0000073400897,0.000010874715,0.000018981347],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027769056,0.00046042327,0.00040756125,0.00026457387,0.00022076964,0.0003395511,0.00068261445,0.00038186467,0.0015048197],"category_scores_gemma":[0.00019602278,0.00026218707,0.00029780425,0.00020065584,0.00015277475,0.0003789163,0.00032184712,0.0006712084,0.0004979342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006825288,0.00024405583,0.00017929597,0.00031513188,0.000050489765,0.00042099814,0.000100949925,0.0027952564,0.9619657,0.002898225,0.00091371685,0.029433666],"study_design_scores_gemma":[0.00052593334,0.0031863651,0.00076849386,0.000028915601,0.0000778139,0.000779447,0.000034794553,0.0051473584,0.9634575,0.0004764511,0.025473187,0.000043663462],"about_ca_topic_score_codex":0.0004883401,"about_ca_topic_score_gemma":0.001389786,"teacher_disagreement_score":0.0015048197,"about_ca_system_score_codex":0.00045354225,"about_ca_system_score_gemma":0.00035464793,"threshold_uncertainty_score":0.005034089},"labels":[],"label_agreement":null},{"id":"W2952552052","doi":"10.1016/j.bmcl.2005.05.131","title":"2-Aminoquinazoline inhibitors of cyclin-dependent kinases","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Kinase; Chemistry; Cyclin-dependent kinase; Threonine; Serine; Protein-Serine-Threonine Kinases; Cyclin-dependent kinase 4; Cell cycle; Cell cycle checkpoint; Cyclin; Cancer research; CHEK1; Biochemistry; Phosphorylation; Cell biology; Cyclin-dependent kinase 2; Cell; Protein kinase A; Biology","score_opus":0.008536263674221296,"score_gpt":0.22215646523705243,"score_spread":0.21362020156283112,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952552052","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8143509,0.11151485,0.014949487,0.0015923205,0.0008732939,0.000312578,0.00097434956,0.001123586,0.05430864],"genre_scores_gemma":[0.9699008,0.016764542,0.002474864,0.00021410757,0.00012214127,0.00008143659,0.0004350546,0.000034374534,0.009972722],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998952,0.000026190753,0.0000066143093,0.000013698229,0.000021741575,0.000036684414],"domain_scores_gemma":[0.99995613,0.0000138322575,0.000008772158,0.0000045764878,0.00000819564,0.000008422638],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022028372,0.00029786414,0.00038478588,0.00030362836,0.00021408239,0.00026554707,0.00039061613,0.0002217299,0.0027082365],"category_scores_gemma":[0.00016944534,0.00011418835,0.00019093438,0.00016862203,0.000121785626,0.00019653632,0.00019794567,0.0003982313,0.00041787748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010096533,0.00017096644,0.0003793443,0.0004637631,0.00003620939,0.0004232057,0.00012455544,0.0011372116,0.9222456,0.0062259077,0.0028030926,0.06498044],"study_design_scores_gemma":[0.0011824344,0.0031637307,0.0045452267,0.000070197195,0.00006254862,0.0016482362,0.000062963016,0.0028542741,0.8563012,0.0011691513,0.1288948,0.00004518099],"about_ca_topic_score_codex":0.00087526464,"about_ca_topic_score_gemma":0.0027153846,"teacher_disagreement_score":0.0027082365,"about_ca_system_score_codex":0.00048685411,"about_ca_system_score_gemma":0.00018032127,"threshold_uncertainty_score":0.009059906},"labels":[],"label_agreement":null},{"id":"W2952900057","doi":"10.1016/j.bmcl.2004.07.027","title":"A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cyclooxygenase; Alkyl; Stereochemistry; Selectivity; Sulfone; In vitro; Chemical synthesis; Enzyme inhibitor; Enzyme; Biochemistry; Organic chemistry; Catalysis","score_opus":0.005527639429397176,"score_gpt":0.22532546457568628,"score_spread":0.2197978251462891,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2952900057","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8776349,0.04975091,0.025202323,0.0008094802,0.0005820497,0.0003308107,0.0022197997,0.0010444947,0.04242526],"genre_scores_gemma":[0.9474388,0.020171402,0.009536328,0.00064364343,0.0001303316,0.00018466583,0.0014685564,0.000050289393,0.020376047],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999411,0.0000074329955,0.0000043992486,0.000011976534,0.000009880212,0.00002515898],"domain_scores_gemma":[0.9999701,0.0000038759135,0.000006914237,0.0000037623367,0.000004241864,0.000011042757],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015498207,0.0004142257,0.0002827567,0.00029117067,0.00015717992,0.0002344269,0.00040366908,0.00025399457,0.0031636502],"category_scores_gemma":[0.00008833383,0.000116985146,0.00015006718,0.0002444257,0.00015546236,0.00038202212,0.00027093702,0.00036188163,0.00067332044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015318766,0.0003349551,0.0005672221,0.00049505994,0.00003649182,0.0007611038,0.000109798384,0.0016040698,0.8493906,0.005468441,0.0034034073,0.13629705],"study_design_scores_gemma":[0.0006350749,0.0053530256,0.0044399626,0.000098657365,0.00011320877,0.0020350632,0.00005722022,0.0025560248,0.8017377,0.0011880487,0.18171349,0.00007254592],"about_ca_topic_score_codex":0.00034340753,"about_ca_topic_score_gemma":0.001021911,"teacher_disagreement_score":0.0031636502,"about_ca_system_score_codex":0.0002557788,"about_ca_system_score_gemma":0.00022857837,"threshold_uncertainty_score":0.010583401},"labels":[],"label_agreement":null},{"id":"W2953200459","doi":"10.1016/j.bmcl.2005.10.107","title":"Pyridobenzodiazepines: A novel class of orally active, vasopressin V2 receptor selective agonists","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Vasopressin; Chemistry; Agonist; Antidiuretic; Arginine; Arginine vasopressin receptor 2; Arginine vasopressin receptor 1B; Vasopressin receptor; Pharmacology; Receptor; Orally active; Peptide hormone; Biological activity; Hormone; Endocrinology; Biochemistry; Amino acid; In vitro; Medicine","score_opus":0.019267256436847142,"score_gpt":0.29028791930415665,"score_spread":0.2710206628673095,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2953200459","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91011846,0.042105343,0.014686219,0.00093449897,0.00026210892,0.00015887783,0.0010548047,0.0005323378,0.03014741],"genre_scores_gemma":[0.9550416,0.022790687,0.005022627,0.00047286387,0.0001580888,0.00009239838,0.0007485843,0.000023594337,0.0156496],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999651,0.000004645962,0.0000016675564,0.000008635939,0.0000083505065,0.000011580644],"domain_scores_gemma":[0.9999821,0.0000021982016,0.0000047995554,0.000001217676,0.0000022699967,0.000007443487],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000069081834,0.00026849896,0.00023322056,0.00010352397,0.00014316729,0.00023210276,0.0002718346,0.00017882239,0.0020092682],"category_scores_gemma":[0.00006908164,0.0000828818,0.000072569565,0.00011360665,0.0001353964,0.00018856268,0.00017472517,0.0003611782,0.0005663993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019193206,0.00018979296,0.0007510546,0.00047914675,0.000024094034,0.001108194,0.0001604916,0.0007832329,0.8542559,0.0030503643,0.0039161216,0.13336222],"study_design_scores_gemma":[0.0015880682,0.011194927,0.01337423,0.00008026017,0.00014180395,0.010214861,0.00015622299,0.005083512,0.6940107,0.0015497095,0.26251015,0.00009557528],"about_ca_topic_score_codex":0.00033736037,"about_ca_topic_score_gemma":0.0010821085,"teacher_disagreement_score":0.0020092682,"about_ca_system_score_codex":0.0002005344,"about_ca_system_score_gemma":0.00013342738,"threshold_uncertainty_score":0.0067216754},"labels":[],"label_agreement":null},{"id":"W2954839824","doi":"10.1016/j.bmcl.2019.06.047","title":"Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase","year":2019,"lang":"en","type":"letter","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Reactivity of Heterocycles","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Brookhaven National Laboratory; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; McGill University; U.S. Department of Energy; Office of Science; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Chemistry; Mutant; Moiety; Potency; Catechol; Stereochemistry; Hydrogen bond; Reverse transcriptase; In vitro; Biochemistry; Molecule","score_opus":0.0272887714606392,"score_gpt":0.25661802462365596,"score_spread":0.22932925316301675,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2954839824","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99136215,0.001631344,0.0010477607,0.000508926,0.00009626119,0.000059432925,0.00029866758,0.000030674426,0.0049647647],"genre_scores_gemma":[0.994187,0.0010549261,0.0009457144,0.00013629039,0.000039974566,0.000029590308,0.00029270002,0.0000092828,0.0033045877],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998634,0.000037018268,0.000008305818,0.000016405183,0.00003631917,0.00003843473],"domain_scores_gemma":[0.9999082,0.00003996225,0.000007752497,0.000010240356,0.000020122221,0.000013700366],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020506143,0.0001671061,0.00024708654,0.00009585503,0.00018336064,0.0003252885,0.0002536918,0.0004594581,0.0012871443],"category_scores_gemma":[0.00017390857,0.00009903423,0.00012472946,0.000097438395,0.00020277571,0.00019236759,0.00008380426,0.00043082974,0.00029301445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007137493,0.00017764178,0.00031632063,0.000054944274,0.000008961609,0.00042942414,0.0000470074,0.00024677024,0.9929315,0.00042561023,0.00032878277,0.004319238],"study_design_scores_gemma":[0.00013548555,0.0040703677,0.0030458635,0.0000032248486,0.00003315293,0.0008204153,0.0000641406,0.0014739779,0.98452395,0.00011168187,0.0057105394,0.000007256194],"about_ca_topic_score_codex":0.0017076747,"about_ca_topic_score_gemma":0.0027052127,"teacher_disagreement_score":0.0017076747,"about_ca_system_score_codex":0.00040490626,"about_ca_system_score_gemma":0.0001532783,"threshold_uncertainty_score":0.004305899},"labels":[],"label_agreement":null},{"id":"W2955852147","doi":"10.1016/j.bmcl.2019.06.021","title":"Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Paraza Pharma (Canada)","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Basic Energy Sciences; National Institute of General Medical Sciences; Genentech; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Cyclin-dependent kinase 6; Chemistry; Palbociclib; Polar surface area; Pharmacology; Cell cycle; Cyclin-dependent kinase 1; Kinase; Cancer research; Potency; Cyclin-dependent kinase; Biochemistry; Cell; Cancer; Internal medicine; In vitro; Biology; Breast cancer; Medicine; Metastatic breast cancer","score_opus":0.010539804837653068,"score_gpt":0.2466546069151321,"score_spread":0.23611480207747904,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2955852147","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8800289,0.023012994,0.06569816,0.001989327,0.00046044006,0.0015715469,0.0016491846,0.00090811716,0.024681346],"genre_scores_gemma":[0.96121985,0.010975338,0.01689545,0.0004971764,0.000045096076,0.0002529411,0.0011397584,0.000052284136,0.008922027],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999248,0.000008751504,0.000005212492,0.000015335745,0.000014433909,0.000031436968],"domain_scores_gemma":[0.99997056,0.0000023441587,0.0000058466617,0.0000014404585,0.000006177391,0.000013651787],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018994477,0.0004976056,0.0004613116,0.00028983294,0.00023111388,0.00043582558,0.00058066566,0.0003772412,0.0021486222],"category_scores_gemma":[0.00010766921,0.0002228598,0.0002909176,0.00016748307,0.000126064,0.00023413134,0.0002540435,0.0007096295,0.00080622954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010334272,0.00057359756,0.00035056777,0.00039232514,0.00008811559,0.00069025817,0.0000788091,0.0039362414,0.9294533,0.002318166,0.0023761992,0.058708988],"study_design_scores_gemma":[0.0015676799,0.005824271,0.0013681041,0.00008044368,0.00025567095,0.0017417718,0.00005674264,0.010864699,0.9047565,0.00072485395,0.07269364,0.00006562423],"about_ca_topic_score_codex":0.0009814795,"about_ca_topic_score_gemma":0.0029559615,"teacher_disagreement_score":0.0021486222,"about_ca_system_score_codex":0.00049400696,"about_ca_system_score_gemma":0.0005156386,"threshold_uncertainty_score":0.007187903},"labels":[],"label_agreement":null},{"id":"W2963654051","doi":"10.1016/j.bmcl.2019.07.023","title":"Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; University of California, Irvine; National Institutes of Health","keywords":"Chemistry; Phenoxazine; Cytotoxicity; Protein phosphatase 2; Phenothiazine; Biochemistry; Threonine; Serine; Phosphatase; Stereochemistry; In vitro; Pharmacology; Enzyme","score_opus":0.006751882462872537,"score_gpt":0.20776849653676616,"score_spread":0.20101661407389362,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2963654051","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98603046,0.0006749157,0.010871037,0.00010249133,0.000018194416,0.00009430326,0.00035501763,0.00010330365,0.0017501957],"genre_scores_gemma":[0.9903341,0.0004412948,0.0067434637,0.000030698517,0.0000038234098,0.000052622523,0.00032988688,0.000020909209,0.0020431706],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999099,0.000014997966,0.000007159535,0.000022123995,0.000028536311,0.00001738882],"domain_scores_gemma":[0.99993694,0.000015123994,0.000021289396,0.0000064630717,0.000007794866,0.000012334323],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017166417,0.0002781092,0.00019664822,0.00014885863,0.0001675201,0.00031541585,0.00027462168,0.0002282504,0.00096329226],"category_scores_gemma":[0.00012630886,0.00019932809,0.00016940365,0.00020752364,0.00020850044,0.00015769948,0.00017671885,0.00038979386,0.0002792663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013182807,0.000028603421,0.000094220275,0.000038250975,0.000008708522,0.000040589697,0.000022271608,0.0015091025,0.99622345,0.00034677706,0.000048383423,0.0015078308],"study_design_scores_gemma":[0.000031100386,0.00014727586,0.00030728488,0.00000220595,0.000012620011,0.000037562844,0.000010854383,0.0018898948,0.99563885,0.00002640999,0.0018906574,0.0000053307967],"about_ca_topic_score_codex":0.00078402914,"about_ca_topic_score_gemma":0.0014360893,"teacher_disagreement_score":0.00096329226,"about_ca_system_score_codex":0.000474512,"about_ca_system_score_gemma":0.00018811696,"threshold_uncertainty_score":0.003442824},"labels":[],"label_agreement":null},{"id":"W2963807856","doi":"10.1016/j.bmcl.2019.07.033","title":"Applications of amide isosteres in medicinal chemistry","year":2019,"lang":"fi","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SignalChem (Canada); Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Amide; Combinatorial chemistry; Selectivity; Drug discovery; Chemical synthesis; Stereochemistry; Organic chemistry; Biochemistry; Catalysis; In vitro","score_opus":0.01398679725144445,"score_gpt":0.26820080817043507,"score_spread":0.2542140109189906,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2963807856","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00036439628,0.99425805,0.000901297,0.00019894898,0.0004327542,0.000010513805,0.0000346292,0.00001899323,0.0037803582],"genre_scores_gemma":[0.003091486,0.9931357,0.00094409025,0.00027829036,0.0003752908,0.000016431783,0.00005323938,0.0000039034485,0.0021014768],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9998197,0.000027398059,0.000017727749,0.00003948354,0.000064103886,0.0000315585],"domain_scores_gemma":[0.9997929,0.00010188606,0.000032244337,0.000012297349,0.000039372426,0.00002132725],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008055991,0.001325254,0.0012478569,0.0024049124,0.00030061722,0.00106677,0.0008694412,0.0009158118,0.004346726],"category_scores_gemma":[0.0006720079,0.00042630822,0.0004936852,0.0023410544,0.00077030633,0.0016490356,0.000985865,0.0028203267,0.0030723086],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013056405,0.00015461171,0.00011036953,0.009303699,0.00007691122,0.00032001425,0.00007497419,0.000759117,0.013631776,0.017081674,0.017475558,0.94088066],"study_design_scores_gemma":[0.00003452855,0.00020508173,0.00035205792,0.0010983229,0.00006824154,0.0006639207,0.000031877036,0.00016969895,0.004832395,0.0042143515,0.9883023,0.000027198377],"about_ca_topic_score_codex":0.0005949331,"about_ca_topic_score_gemma":0.0007365142,"teacher_disagreement_score":0.004346726,"about_ca_system_score_codex":0.00066342414,"about_ca_system_score_gemma":0.00053876406,"threshold_uncertainty_score":0.014541268},"labels":[],"label_agreement":null},{"id":"W2985545877","doi":"10.1016/j.bmcl.2019.126783","title":"Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells – Identifying inhibitors of non-classical pathways producing the most potent androgen","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Faculté de Médecine, Université Laval; Mitacs","keywords":"Androstane; Dihydrotestosterone; Chemistry; Androgen; Testosterone (patch); Prostate cancer; Androgen receptor; IC50; Prostate; Endocrinology; Internal medicine; Stereochemistry; Pharmacology; Cancer; In vitro; Biochemistry; Hormone; Biology; Medicine","score_opus":0.016809240375881593,"score_gpt":0.25418402200544493,"score_spread":0.23737478162956333,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2985545877","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9810259,0.00721659,0.004216602,0.00034276265,0.00016072557,0.00009098444,0.0021702629,0.00020928048,0.0045670103],"genre_scores_gemma":[0.98312885,0.0024022195,0.002818116,0.00010917741,0.000039409373,0.00004999703,0.0038044334,0.000030751675,0.0076170526],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980956,0.000033761862,0.000016336544,0.00002587595,0.00006282183,0.00005164947],"domain_scores_gemma":[0.99990654,0.000025503847,0.000012237276,0.000013164928,0.00001568725,0.000026728312],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025454586,0.0004240462,0.00039414156,0.000374692,0.00019932904,0.00035551997,0.00033511492,0.0003059317,0.0022094366],"category_scores_gemma":[0.000121211444,0.00025003843,0.0004453774,0.0003571366,0.00023026289,0.00021098541,0.00016110847,0.00066517724,0.0008762329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023723037,0.000044867647,0.00012765158,0.00003639951,0.000009455528,0.00006412252,0.000014438791,0.00007928154,0.9982141,0.00008332805,0.0000936275,0.0009954427],"study_design_scores_gemma":[0.000023380417,0.00020964618,0.00085577817,0.0000012695168,0.000008611475,0.00008058751,0.000011096333,0.00022438662,0.99730825,0.000015696884,0.0012590449,0.00000218411],"about_ca_topic_score_codex":0.0013916211,"about_ca_topic_score_gemma":0.0024452659,"teacher_disagreement_score":0.0022094366,"about_ca_system_score_codex":0.00033885555,"about_ca_system_score_gemma":0.00040822013,"threshold_uncertainty_score":0.007391274},"labels":[],"label_agreement":null},{"id":"W2991696022","doi":"10.1016/j.bmcl.2019.126878","title":"Novel hybrid molecules of 3,5-bis(benzylidene)-4-piperidones and dichloroacetic acid which demonstrate potent tumour-selective cytotoxicity","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Maunders Mcneil Foundation; Indiana University","keywords":"Chemistry; Dichloroacetic acid; Cytotoxicity; Stereochemistry; Structure–activity relationship; Cytotoxic T cell; IC50; Molecule; Chemical synthesis; Lactate dehydrogenase; In vitro; Biochemistry; Enzyme; Organic chemistry","score_opus":0.005947502998418732,"score_gpt":0.2036958684579402,"score_spread":0.19774836545952146,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2991696022","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9838674,0.0019233291,0.0074021965,0.000090690315,0.000044308872,0.00006124739,0.00017894407,0.0002453997,0.006186451],"genre_scores_gemma":[0.9920684,0.00051203964,0.0042815274,0.00005346812,0.000013672737,0.000052949374,0.0001655938,0.00001909556,0.0028333],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99990296,0.000017682454,0.0000058637106,0.000019738585,0.00002469204,0.00002915063],"domain_scores_gemma":[0.9999163,0.000018220439,0.000024925226,0.000008347121,0.0000081141525,0.000024035502],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014016073,0.00029599774,0.0002643026,0.00013487788,0.000106824904,0.00025952197,0.0004196237,0.00026783702,0.0011993627],"category_scores_gemma":[0.000116317504,0.0001503416,0.00011378053,0.00014461382,0.0002015446,0.00019378104,0.00021840776,0.00032688983,0.00026575555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002517757,0.000045638604,0.000081716455,0.00006340022,0.000010234941,0.00007893718,0.00002505002,0.0005053692,0.9943182,0.00070964335,0.000110332214,0.003799737],"study_design_scores_gemma":[0.00007069594,0.0005890545,0.00084691524,0.0000037111859,0.000019312381,0.00021354781,0.000011061975,0.0016661856,0.993067,0.000050769282,0.0034513467,0.000010352247],"about_ca_topic_score_codex":0.00041136274,"about_ca_topic_score_gemma":0.0006130852,"teacher_disagreement_score":0.0011993627,"about_ca_system_score_codex":0.00026936998,"about_ca_system_score_gemma":0.00011469535,"threshold_uncertainty_score":0.0040122867},"labels":[],"label_agreement":null},{"id":"W3001596779","doi":"10.1016/j.bmcl.2020.126983","title":"Identification of a C3′-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Glycomics Network; Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Gemcitabine; Cell culture; Nucleoside; Pancreatic cancer; KRAS; Nitrile; Cancer research; Nucleoside analogue; Cancer; Cancer cell lines; Biochemistry; Cancer cell; Internal medicine; Mutation; Gene; Genetics; Biology","score_opus":0.023065852793961436,"score_gpt":0.285759881517913,"score_spread":0.26269402872395153,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3001596779","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98183167,0.0039048286,0.006187437,0.00017834626,0.00006724035,0.00018222198,0.00082786754,0.00018314605,0.0066371635],"genre_scores_gemma":[0.9843076,0.002816747,0.0055029998,0.00013624868,0.000024212874,0.00010806152,0.002551191,0.000034221972,0.004518688],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998913,0.000018331546,0.000009379103,0.000022511658,0.000029758214,0.000028672586],"domain_scores_gemma":[0.9999018,0.000027555545,0.000015196733,0.000015477142,0.00002176105,0.000018262604],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807642,0.00039582246,0.0005245926,0.00026839453,0.00019360616,0.00026176596,0.00040439394,0.00033380793,0.002139917],"category_scores_gemma":[0.00015703011,0.00016860821,0.0003639589,0.00022566064,0.00014108824,0.00013377135,0.00017975373,0.00055515574,0.0006310371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019835537,0.00007202787,0.00016518096,0.000039189676,0.000011229273,0.00012406702,0.000012303081,0.00009658001,0.9959318,0.00006798741,0.00007959577,0.0032016232],"study_design_scores_gemma":[0.00004443954,0.0008057655,0.0025050046,0.0000055911933,0.000037709633,0.0005265822,0.000012289141,0.0006252551,0.99171716,0.000018209937,0.00369678,0.000005202041],"about_ca_topic_score_codex":0.0010063071,"about_ca_topic_score_gemma":0.0014215459,"teacher_disagreement_score":0.002139917,"about_ca_system_score_codex":0.00025261918,"about_ca_system_score_gemma":0.00028194318,"threshold_uncertainty_score":0.0071587563},"labels":[],"label_agreement":null},{"id":"W3005560412","doi":"10.1016/j.bmcl.2020.127040","title":"Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Universidade Estadual de Campinas; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; University of Sussex; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novartis Pharma; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Pfizer","keywords":"Kinome; Kinase; Chemistry; Computational biology; Chemical biology; Cancer; Biochemistry; Biology; Genetics","score_opus":0.02888128636798859,"score_gpt":0.28228341937389967,"score_spread":0.2534021330059111,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3005560412","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8192377,0.04319011,0.09396923,0.0016261431,0.0005605776,0.0013258656,0.0015546137,0.00108761,0.037448205],"genre_scores_gemma":[0.9407598,0.016614132,0.031169051,0.00042625197,0.00006449032,0.00040835573,0.0006657679,0.000048161146,0.009844021],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998324,0.00004156703,0.000008383116,0.000030853837,0.00004740716,0.000039330745],"domain_scores_gemma":[0.9999337,0.00001388929,0.0000148964,0.0000068644017,0.000012134862,0.000018419527],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004219132,0.0004729622,0.0003010058,0.00031469765,0.00020922015,0.00028372346,0.0005407989,0.00051430985,0.0017854271],"category_scores_gemma":[0.00023102906,0.00022293333,0.00023387477,0.00022747218,0.00025470025,0.0003612691,0.00031718687,0.0007288376,0.0007601214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015606539,0.00012733655,0.00011115488,0.00032213185,0.000017566032,0.00021120522,0.00008174884,0.0011081334,0.98222005,0.0022685132,0.0005572487,0.012818811],"study_design_scores_gemma":[0.00019225203,0.002505753,0.001048228,0.000050191844,0.000030801184,0.0005564419,0.0000428404,0.0028850625,0.9615808,0.0004614746,0.03061436,0.000031714793],"about_ca_topic_score_codex":0.00052062026,"about_ca_topic_score_gemma":0.0016751097,"teacher_disagreement_score":0.0017854271,"about_ca_system_score_codex":0.00043120523,"about_ca_system_score_gemma":0.00032010474,"threshold_uncertainty_score":0.0059728622},"labels":[],"label_agreement":null},{"id":"W3008934877","doi":"10.1016/j.bmcl.2020.127067","title":"Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Canada; Università degli Studi di Ferrara; Associazione Italiana per la Ricerca sul Cancro; Università degli Studi di Firenze; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Chemistry; Adenosine; Adenosine receptor; Pyrimidine; Stereochemistry; Receptor; Enzyme; G protein-coupled receptor; Potency; Adenosine A2A receptor; Pharmacology; Biochemistry; Combinatorial chemistry; In vitro; Agonist","score_opus":0.02091210705638539,"score_gpt":0.23842988502916782,"score_spread":0.21751777797278243,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3008934877","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9825533,0.005523702,0.004245338,0.0003881958,0.00007683678,0.000096357086,0.0002689192,0.00007785477,0.006769328],"genre_scores_gemma":[0.9889042,0.004106431,0.003929245,0.00012503016,0.000017127766,0.000030577085,0.00024610473,0.000007293845,0.0026341013],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99995637,0.000007647355,0.0000027574097,0.000006711477,0.000011449951,0.000015143426],"domain_scores_gemma":[0.99996984,0.0000048894653,0.000007951537,0.0000025937113,0.0000047350745,0.000009972986],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012551321,0.00021064331,0.00021037317,0.000115827956,0.00021030116,0.00018288377,0.00029565734,0.00023061752,0.002398599],"category_scores_gemma":[0.00010076654,0.00009935395,0.00014683732,0.00012275076,0.00015836916,0.00016646586,0.00012863344,0.00035506574,0.0002992512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037749333,0.00013023855,0.0001884897,0.00020668266,0.00001646196,0.000505518,0.00005452583,0.0021166361,0.9827305,0.0026492453,0.000360772,0.0106634395],"study_design_scores_gemma":[0.00053565897,0.0053796014,0.0034949596,0.00006423445,0.000118126896,0.001542105,0.00011217367,0.0095326705,0.9454552,0.00076372136,0.03295275,0.000048709226],"about_ca_topic_score_codex":0.001063249,"about_ca_topic_score_gemma":0.0021657003,"teacher_disagreement_score":0.002398599,"about_ca_system_score_codex":0.00027705348,"about_ca_system_score_gemma":0.00037743078,"threshold_uncertainty_score":0.008024156},"labels":[],"label_agreement":null},{"id":"W3035909825","doi":"10.1016/j.bmcl.2020.127356","title":"Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Chemistry; Immunoglobulin light chain; Antibody; Combinatorial chemistry; Immunoglobulin G; Stereochemistry; Immunology","score_opus":0.01241767158571587,"score_gpt":0.2321611714067424,"score_spread":0.21974349982102653,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3035909825","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9922346,0.00084360316,0.0036531189,0.00057034544,0.00005617004,0.000023131925,0.00008115761,0.00004767717,0.002490068],"genre_scores_gemma":[0.99923253,0.00013525429,0.00033209927,0.000037517373,0.000006075253,0.0000032068024,0.000032464523,0.000002823362,0.00021799737],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999366,0.000012360401,0.0000044431504,0.000012307941,0.000012949341,0.000021308826],"domain_scores_gemma":[0.9998826,0.0000321125,0.000035179568,0.000012118849,0.000013041714,0.000025020696],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000177349,0.00018930489,0.00013980287,0.00010373832,0.00025341523,0.00023821216,0.00033983903,0.00031177676,0.0016645589],"category_scores_gemma":[0.0002618758,0.00009027101,0.00015405122,0.000054448385,0.0004037957,0.00022846005,0.00023031385,0.00035115713,0.00021693215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00086846604,0.0001332984,0.001857716,0.000108656444,0.00003321361,0.0014785381,0.00009834902,0.0036582446,0.97513163,0.012142074,0.0004494477,0.004040312],"study_design_scores_gemma":[0.00017657162,0.0012170923,0.0063895048,0.000014693765,0.000038524457,0.001254079,0.00015977614,0.012160667,0.96687794,0.0075178,0.004164826,0.000028613797],"about_ca_topic_score_codex":0.00036976073,"about_ca_topic_score_gemma":0.0002780487,"teacher_disagreement_score":0.0016645589,"about_ca_system_score_codex":0.00030125128,"about_ca_system_score_gemma":0.00023416038,"threshold_uncertainty_score":0.0055684447},"labels":[],"label_agreement":null},{"id":"W3042483363","doi":"10.1016/j.bmcl.2020.127414","title":"Intestinal anti-inflammatory activity of the total alkaloid fraction from Fumaria capreolata in the DSS model of colitis in mice","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Center for International Business Education and Research, University of Illinois at Urbana-Champaign; Junta de Andalucía; European Commission; Instituto de Salud Carlos III; Canadian Thoracic Society","keywords":"Colitis; Inflammatory bowel disease; Chemistry; In vivo; Alkaloid; Inflammation; Pharmacology; Anti-inflammatory; Bone marrow; Immunology; Pathology; Biology; Medicine; Disease; Stereochemistry","score_opus":0.02528203714409034,"score_gpt":0.25311987400406805,"score_spread":0.22783783685997772,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3042483363","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9925161,0.0038125387,0.0011889793,0.00015183125,0.00004543969,0.000026266445,0.0006006881,0.00007057342,0.0015875243],"genre_scores_gemma":[0.99320227,0.0017286857,0.0009590447,0.00010293685,0.000025701223,0.000017465125,0.00078891194,0.000013010222,0.0031620795],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99996996,0.000003817978,0.000002238697,0.0000063966845,0.000007482456,0.000010101484],"domain_scores_gemma":[0.9999465,0.000008220616,0.00001007064,0.00000391441,0.000010714621,0.000020674534],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000059557322,0.00039422672,0.00034014956,0.00046853724,0.00017785466,0.00014051454,0.00014499559,0.0002384062,0.0016258988],"category_scores_gemma":[0.000064983964,0.000108236934,0.00020315444,0.00015308842,0.00013557971,0.0001959133,0.00010731702,0.00037232062,0.00025771558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007046227,0.00007449912,0.00014296132,0.00010963378,0.000015406285,0.000054233537,0.000019050332,0.00006485101,0.99611974,0.00003436573,0.00005295292,0.0026076713],"study_design_scores_gemma":[0.00015780913,0.003029623,0.015808675,0.000034674627,0.00021491041,0.00035673915,0.00008303451,0.00087576266,0.97461706,0.00008766588,0.004714832,0.000019206356],"about_ca_topic_score_codex":0.0010007242,"about_ca_topic_score_gemma":0.0015271411,"teacher_disagreement_score":0.0016258988,"about_ca_system_score_codex":0.00009028754,"about_ca_system_score_gemma":0.000144067,"threshold_uncertainty_score":0.0054391623},"labels":[],"label_agreement":null},{"id":"W3070343628","doi":"10.1016/j.bmcl.2020.127502","title":"Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Grand Challenges Canada; California Polytechnic State University, San Luis Obispo","keywords":"Potency; Plasmodium falciparum; Chemistry; Lead compound; Pharmacology; In vitro; Shock (circulatory); Structure–activity relationship; Toxicity; Stereochemistry; Biochemistry; Malaria; Immunology; Biology; Medicine","score_opus":0.016957521085500343,"score_gpt":0.24264567717516036,"score_spread":0.22568815608966003,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3070343628","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98103964,0.007355579,0.0044276365,0.00018437835,0.000053838718,0.0002234662,0.00034119858,0.00014055702,0.0062337643],"genre_scores_gemma":[0.9873719,0.0043722442,0.005078826,0.00009875431,0.000017359718,0.000054972388,0.00043259675,0.000016927786,0.0025565256],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992764,0.000020124839,0.000005584305,0.000013882664,0.000016556987,0.000016215934],"domain_scores_gemma":[0.9999318,0.000012342556,0.000015280593,0.0000063976913,0.000018416875,0.000015678823],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589848,0.00029588063,0.00027761617,0.0002598577,0.00012226526,0.00019049103,0.00036975121,0.0001964329,0.0012213588],"category_scores_gemma":[0.00018692204,0.00014744766,0.00014415069,0.00016545704,0.00018582118,0.00012581325,0.00014844771,0.000445813,0.00026359697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005107971,0.00025609674,0.00030915916,0.00019156573,0.000020705185,0.00019239767,0.000057559457,0.002099848,0.97477597,0.0005139449,0.00026347625,0.020808563],"study_design_scores_gemma":[0.00033097956,0.0065882117,0.0016628125,0.000031330757,0.000047382582,0.00060892483,0.000035212888,0.0030723421,0.97719336,0.00012380347,0.01028195,0.000023707486],"about_ca_topic_score_codex":0.0011482593,"about_ca_topic_score_gemma":0.0027467455,"teacher_disagreement_score":0.0012213588,"about_ca_system_score_codex":0.00021837401,"about_ca_system_score_gemma":0.00026905892,"threshold_uncertainty_score":0.004085839},"labels":[],"label_agreement":null},{"id":"W3087745752","doi":"10.1016/j.bmcl.2020.127559","title":"Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Stanley Foundation; Stanley Medical Research Institute","keywords":"Pharmacophore; Chemistry; Herpes simplex virus; Hydrazone; Nucleoside; Chemical synthesis; Structure–activity relationship; Stereochemistry; Virology; Virus; HSL and HSV; In vitro; Biochemistry","score_opus":0.028549129940189627,"score_gpt":0.2925718930526448,"score_spread":0.2640227631124552,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3087745752","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93621606,0.009477311,0.027773077,0.0007101736,0.00026590054,0.0011063633,0.0025752028,0.00046001986,0.021415843],"genre_scores_gemma":[0.97702914,0.0058870683,0.008800257,0.00014970334,0.000039969782,0.00026013836,0.0009768249,0.000030831634,0.006826121],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999858,0.000021362392,0.000011905166,0.000017968086,0.000024646253,0.00006606653],"domain_scores_gemma":[0.9998622,0.000030165054,0.000023690283,0.000019124274,0.000031842636,0.000032905104],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028635838,0.00044898575,0.0003370333,0.00024767572,0.00025670597,0.0001509888,0.00047425646,0.00033070432,0.003911939],"category_scores_gemma":[0.00025495488,0.0002108527,0.00028558844,0.00031347355,0.0002016084,0.00026015492,0.000257565,0.00047769464,0.000881812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007437759,0.00032820346,0.0002789443,0.0006214187,0.000030612104,0.000829044,0.00019505214,0.0022365572,0.96342325,0.0019906575,0.0012223059,0.028100157],"study_design_scores_gemma":[0.0001380397,0.0024057578,0.0016006421,0.000028102135,0.000038967868,0.00037182923,0.000043028405,0.00082100125,0.9821931,0.00019517764,0.012134237,0.000029998817],"about_ca_topic_score_codex":0.001263962,"about_ca_topic_score_gemma":0.0019923912,"teacher_disagreement_score":0.003911939,"about_ca_system_score_codex":0.00038418203,"about_ca_system_score_gemma":0.0005455134,"threshold_uncertainty_score":0.013086736},"labels":[],"label_agreement":null},{"id":"W3088262682","doi":"10.1016/j.bmcl.2020.127575","title":"Overcoming β-Lactam resistance in Pseudomonas aeruginosa using non-canonical tobramycin-based antibiotic adjuvants","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba","keywords":"Efflux; Pseudomonas aeruginosa; Antibiotics; Lactam; Chemistry; Antibiotic resistance; Porin; Microbiology; Antimicrobial; Tobramycin; Drug resistance; Bacteria; Bacterial outer membrane; Biology; Biochemistry; Stereochemistry; Escherichia coli; Genetics; Gene","score_opus":0.015786498477853864,"score_gpt":0.24654098536204844,"score_spread":0.2307544868841946,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3088262682","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9926664,0.001487963,0.004280277,0.0001489944,0.000037741946,0.000023599216,0.000045704357,0.00009812155,0.0012111645],"genre_scores_gemma":[0.9951088,0.0007465479,0.0028151835,0.00005805856,0.00000915035,0.000013388676,0.000047880072,0.000012067927,0.0011890434],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991715,0.000016365015,0.0000058849027,0.000010306266,0.00001998909,0.000030285646],"domain_scores_gemma":[0.99993753,0.0000100481975,0.000015826134,0.000006453873,0.00001276061,0.000017393051],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010472179,0.0002107546,0.00019346886,0.00011728527,0.00007541652,0.00031065076,0.00014517794,0.00020157764,0.0005342924],"category_scores_gemma":[0.00019213479,0.000072933166,0.00010619915,0.000080345024,0.00013042547,0.00020270476,0.00031203192,0.00043098128,0.00024673154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007365159,0.000024738305,0.000074874675,0.000026094418,0.0000019954243,0.000022973689,0.000007694048,0.0001616653,0.9969748,0.00012014965,0.000030299427,0.0024809265],"study_design_scores_gemma":[0.000021887512,0.00050399685,0.0005396302,0.0000106006155,0.000011930555,0.00016395998,0.000025771056,0.0015878254,0.9928833,0.00008699416,0.004158062,0.0000060829875],"about_ca_topic_score_codex":0.00023753311,"about_ca_topic_score_gemma":0.00058540684,"teacher_disagreement_score":0.0005342924,"about_ca_system_score_codex":0.00017182776,"about_ca_system_score_gemma":0.00018823898,"threshold_uncertainty_score":0.0017874241},"labels":[],"label_agreement":null},{"id":"W3089104566","doi":"10.1016/j.bmcl.2020.127577","title":"A guanidinium-based inhibitor of a type I isopentenyl diphosphate isomerase","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Isomerase; Carbocation; Enzyme; Stereochemistry; Farnesyl diphosphate synthase; Biochemistry; Guanidine; ATP synthase; Organic chemistry","score_opus":0.01315364687218032,"score_gpt":0.20976587574395675,"score_spread":0.19661222887177643,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3089104566","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95649505,0.008403052,0.010178631,0.0008369604,0.0006133549,0.00025425703,0.00033733234,0.00062311604,0.022258237],"genre_scores_gemma":[0.9885212,0.0022709274,0.0049944683,0.00028296726,0.00006203665,0.000045897952,0.0002592924,0.000031021387,0.0035321438],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998945,0.000016381555,0.000006452648,0.000021134912,0.00002125137,0.000040310748],"domain_scores_gemma":[0.9999348,0.000017915705,0.000010759376,0.0000061930136,0.000006537259,0.00002386041],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023162612,0.0003505584,0.00031757206,0.00016760816,0.0002396528,0.0002327392,0.00058026146,0.00053857156,0.0013136525],"category_scores_gemma":[0.00018426449,0.0002106897,0.00017607164,0.000100688456,0.00018757443,0.0001823233,0.00023977028,0.00082179887,0.00031746793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00077182526,0.00016079785,0.00010920544,0.000118753764,0.000021441982,0.00032693514,0.00002378101,0.0002999605,0.9859871,0.001020607,0.0006194717,0.010540107],"study_design_scores_gemma":[0.0007449764,0.002328811,0.0014738159,0.00002231744,0.00005218632,0.0008481641,0.000015557278,0.0032008328,0.97986364,0.00022096183,0.0112047875,0.000023845245],"about_ca_topic_score_codex":0.0008612925,"about_ca_topic_score_gemma":0.0016314781,"teacher_disagreement_score":0.0013136525,"about_ca_system_score_codex":0.00031542548,"about_ca_system_score_gemma":0.00030936336,"threshold_uncertainty_score":0.004394591},"labels":[],"label_agreement":null},{"id":"W3089249760","doi":"10.1016/j.bmcl.2020.127573","title":"Synthesis and in vitro evaluation of new TRPV4 ligands and biodistribution study of an 11C-labeled radiotracer in rodents","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; Institute of Aging; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of South Alabama","keywords":"Radiosynthesis; Chemistry; Biodistribution; Radiochemistry; In vivo; In vitro; Agonist; Chemical synthesis; Ex vivo; Nuclear chemistry; Methyl iodide; Biochemistry; Receptor; Medicinal chemistry","score_opus":0.05034228892066872,"score_gpt":0.2834363017434445,"score_spread":0.23309401282277575,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3089249760","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9476532,0.005074976,0.0415334,0.00025625777,0.000100567064,0.0003786352,0.001285872,0.00035001608,0.003367117],"genre_scores_gemma":[0.92941993,0.004649759,0.05070011,0.00021153486,0.000057763606,0.00045292737,0.0032244187,0.00015915783,0.011124398],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981326,0.00003700695,0.000015425969,0.00003907334,0.000025171506,0.00007013731],"domain_scores_gemma":[0.9997583,0.000045083005,0.000060545764,0.00003071762,0.000049193608,0.000056104993],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005645109,0.00065243396,0.00046486376,0.0004883731,0.0003173142,0.0004279579,0.00078141934,0.00054376345,0.0011882795],"category_scores_gemma":[0.0003591464,0.00036556472,0.0004500313,0.00029099945,0.00026491465,0.00047593281,0.00027512247,0.0006111507,0.00059754605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047540484,0.00015595113,0.00009319091,0.000102945276,0.000017237451,0.00013651227,0.000029920979,0.00062577525,0.9953166,0.00033873078,0.000091627284,0.0026160723],"study_design_scores_gemma":[0.000057909034,0.0015279708,0.00023575286,0.000007757592,0.000058763166,0.0002690488,0.000022224507,0.000622255,0.99368435,0.00007026795,0.0034312573,0.000012445294],"about_ca_topic_score_codex":0.00067077257,"about_ca_topic_score_gemma":0.0006924292,"teacher_disagreement_score":0.0011882795,"about_ca_system_score_codex":0.0004072884,"about_ca_system_score_gemma":0.00038770208,"threshold_uncertainty_score":0.0039752126},"labels":[],"label_agreement":null},{"id":"W3120999347","doi":"10.1016/j.bmcl.2021.127781","title":"Development of sulfahydantoin derivatives as β-lactamase inhibitors","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Enzyme; Isocyanate; Stereochemistry; Molecule; Combinatorial chemistry; Antibiotics; Chemical synthesis; Lactam; Broad spectrum; Beta-Lactamase Inhibitors; Enzyme inhibitor; Biochemistry; In vitro; Organic chemistry","score_opus":0.008435862531392235,"score_gpt":0.2348296676970588,"score_spread":0.22639380516566657,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3120999347","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9639888,0.010793202,0.015392505,0.00044569405,0.00014621684,0.00013913271,0.00033068113,0.00026141127,0.008502433],"genre_scores_gemma":[0.98290586,0.005781917,0.0065756696,0.00009144387,0.000023215041,0.000059967493,0.00036086974,0.000024215427,0.004176839],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993384,0.000016634438,0.0000061385695,0.00001084728,0.000017256447,0.000015336322],"domain_scores_gemma":[0.99995387,0.000008101011,0.000010589164,0.000005272107,0.000009018193,0.000013080436],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018895594,0.00032259978,0.00023205871,0.0001776638,0.00010520351,0.00023666954,0.00024817637,0.0002546665,0.0010472474],"category_scores_gemma":[0.00011947718,0.00014099275,0.00018526407,0.00013417043,0.00014746592,0.00021139138,0.00017048627,0.0004057942,0.00029126814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021241653,0.00009380944,0.00014892414,0.0000880471,0.000016093136,0.0001615613,0.000032519816,0.0010961768,0.98284286,0.00090318406,0.00025033846,0.014154116],"study_design_scores_gemma":[0.00005481068,0.00091950165,0.00038792216,0.000007688943,0.000019415762,0.00017864707,0.000011620402,0.0014927121,0.9881094,0.00009872859,0.008712664,0.0000068204245],"about_ca_topic_score_codex":0.00024208207,"about_ca_topic_score_gemma":0.00043769873,"teacher_disagreement_score":0.0010472474,"about_ca_system_score_codex":0.00021625581,"about_ca_system_score_gemma":0.0001622324,"threshold_uncertainty_score":0.0035034418},"labels":[],"label_agreement":null},{"id":"W3158031655","doi":"10.1016/j.bmcl.2021.128053","title":"Circular dichroism spectroscopy of DNA duplexes at near-biological concentrations","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University","keywords":"Nucleic acid; Chemistry; Circular dichroism; Nucleic acid structure; DNA; Cuvette; Biochemistry; Biophysics; RNA","score_opus":0.00863012049782427,"score_gpt":0.22208201439091424,"score_spread":0.21345189389308997,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3158031655","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98621804,0.00090968265,0.007039932,0.00025407507,0.000039793864,0.000025038673,0.00044281466,0.00011894821,0.0049517206],"genre_scores_gemma":[0.9918977,0.0005135437,0.0035911973,0.0001911165,0.00001276649,0.00004213743,0.0006737236,0.000019298142,0.0030584456],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99970573,0.00007140357,0.000015224068,0.000076506796,0.000074918695,0.00005609209],"domain_scores_gemma":[0.9994584,0.00030157028,0.000057224624,0.000034998633,0.00009089606,0.000057005927],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031704418,0.00026175895,0.00017165893,0.0003019221,0.00034659725,0.00023482888,0.0003068425,0.00047813178,0.0028210778],"category_scores_gemma":[0.00068867434,0.0001828714,0.00012972073,0.00032976925,0.0003450056,0.00026205587,0.00015106772,0.0007348005,0.0004985297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019261155,0.000044909164,0.00022746933,0.000038554434,0.000006703955,0.00004895263,0.00007613088,0.00019579202,0.99750584,0.00024260885,0.000111572765,0.0013089956],"study_design_scores_gemma":[0.000014556299,0.00029519774,0.0024064223,0.000009107831,0.000009116259,0.000109496636,0.00007712578,0.0015200689,0.99442405,0.00013574777,0.0009881788,0.000010970238],"about_ca_topic_score_codex":0.00059342355,"about_ca_topic_score_gemma":0.0005887025,"teacher_disagreement_score":0.0028210778,"about_ca_system_score_codex":0.0002810503,"about_ca_system_score_gemma":0.00021426578,"threshold_uncertainty_score":0.009437501},"labels":[],"label_agreement":null},{"id":"W3159770748","doi":"10.1016/j.bmcl.2021.128089","title":"Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Mitacs; Canada Research Chairs; Canadian Institute for Advanced Research","keywords":"Fungicide; Chemistry; Stereochemistry; Antifungal; Structure–activity relationship; Colletotrichum; Combinatorial chemistry; Biochemistry; Botany; In vitro; Biology; Microbiology","score_opus":0.04174390633698547,"score_gpt":0.2605592254048065,"score_spread":0.21881531906782106,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3159770748","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9786896,0.01154629,0.0048053986,0.00029152192,0.0000503912,0.00011795907,0.0004971313,0.00009690139,0.003904821],"genre_scores_gemma":[0.98280126,0.008928448,0.004885017,0.0001488913,0.000014202936,0.000030054916,0.0003897248,0.000013644352,0.0027887113],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99994016,0.000009469665,0.0000039459633,0.000012676429,0.00001350246,0.000020340021],"domain_scores_gemma":[0.9999473,0.000008961515,0.000014236876,0.0000040582295,0.000013178817,0.000012305513],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658138,0.0003272216,0.00031688827,0.00023338028,0.00015305835,0.00026696868,0.00029384563,0.00023811271,0.0016448613],"category_scores_gemma":[0.0001241091,0.00013846016,0.0002684652,0.00022590325,0.00014903318,0.0002858734,0.00018234541,0.00040615725,0.00024624317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042974943,0.00017814523,0.0004085944,0.00023637078,0.000035009358,0.000112773014,0.000029611045,0.0007400421,0.98517483,0.00030269154,0.00022619107,0.012126064],"study_design_scores_gemma":[0.00022103544,0.0064106476,0.004047334,0.00005050168,0.00014532455,0.00043282908,0.000087178814,0.0027946483,0.97302973,0.00016606876,0.012568752,0.00004589223],"about_ca_topic_score_codex":0.00072558044,"about_ca_topic_score_gemma":0.00284404,"teacher_disagreement_score":0.0016448613,"about_ca_system_score_codex":0.00020514651,"about_ca_system_score_gemma":0.00021046626,"threshold_uncertainty_score":0.0055025816},"labels":[],"label_agreement":null},{"id":"W3160631478","doi":"10.1016/j.bmcl.2021.128119","title":"The isolation, purification and complete characterization of the diterpene forskolin from nutritional supplements","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"University of Manitoba","keywords":"Forskolin; Diterpene; Coleus; Chemistry; Adenylyl cyclase; Characterization (materials science); Stereochemistry; Biochemistry; Enzyme; Botany; In vitro; Nanotechnology; Biology","score_opus":0.050863259334255756,"score_gpt":0.3478838153186752,"score_spread":0.29702055598441945,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3160631478","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9614984,0.014233045,0.017684545,0.00061634346,0.000092987146,0.00015883599,0.0016414694,0.00014504378,0.0039293543],"genre_scores_gemma":[0.97064507,0.0065316465,0.012882683,0.00014434622,0.000025005365,0.000047489604,0.0023196768,0.000066249195,0.00733784],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991786,0.000010984728,0.000011031697,0.000016023494,0.000025462748,0.00001857565],"domain_scores_gemma":[0.9998729,0.000038667087,0.00002030826,0.000021963617,0.000028901155,0.000017361403],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011363991,0.00037388757,0.0002525084,0.00044062897,0.0002586559,0.0003567058,0.00014702955,0.00019718012,0.0007821658],"category_scores_gemma":[0.00027840154,0.000118815944,0.00031592115,0.00029801327,0.00027050133,0.00035783934,0.0003108988,0.0004220904,0.00049685955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000771716,0.0000075995995,0.00010633139,0.000053593027,0.0000048245684,0.00006291761,0.000028123015,0.000047481917,0.9951041,0.00009676137,0.0000318985,0.0043791817],"study_design_scores_gemma":[0.000006249362,0.00006526161,0.0015433652,0.000006970052,0.000016872395,0.00022861148,0.000025300698,0.000108105676,0.9918643,0.00007548143,0.0060518677,0.000007583647],"about_ca_topic_score_codex":0.0011567115,"about_ca_topic_score_gemma":0.0022565394,"teacher_disagreement_score":0.0011567115,"about_ca_system_score_codex":0.00032117617,"about_ca_system_score_gemma":0.0006307927,"threshold_uncertainty_score":0.0026165843},"labels":[],"label_agreement":null},{"id":"W3163100393","doi":"10.1016/j.bmcl.2021.128107","title":"Cytotoxicity, anti-tumor effects and structure-activity relationships of nickel and palladium S,C,S pincer complexes against double and triple-positive and triple-negative breast cancer (TNBC) cells","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Department of Chemistry, University of York; Iran University of Science and Technology; Iran National Science Foundation","keywords":"Chemistry; Triple-negative breast cancer; Palladium; Cancer research; Breast cancer; Stereochemistry; Cancer; Internal medicine; Medicine; Biochemistry","score_opus":0.021499070684131014,"score_gpt":0.24287406428567196,"score_spread":0.22137499360154095,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3163100393","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9932514,0.0034696616,0.0005083344,0.000059192655,0.000026462041,0.000023141944,0.00026774747,0.000029801313,0.0023644716],"genre_scores_gemma":[0.99547184,0.0013908419,0.0003302879,0.000024770625,0.0000066573925,0.000014668986,0.00036050793,0.000004586945,0.0023959656],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999037,0.00002111502,0.000015709395,0.000015878602,0.000020438718,0.000023200377],"domain_scores_gemma":[0.9999397,0.000013704875,0.0000107424385,0.0000066239645,0.000014581335,0.000014683034],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012662783,0.00021615336,0.00024358352,0.000219958,0.00013161395,0.00021088205,0.00022441446,0.00018257835,0.0012365133],"category_scores_gemma":[0.00015798966,0.00012932562,0.00016799792,0.00024163515,0.00014072948,0.00013884634,0.00012987755,0.00020457321,0.00022048566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016135615,0.00014444388,0.0004233579,0.00020819128,0.000021072483,0.00011802631,0.00006854436,0.000498981,0.99038625,0.00017838633,0.00017239743,0.0061667957],"study_design_scores_gemma":[0.00003453868,0.0015309063,0.001674411,0.0000055925184,0.00003702923,0.00019034721,0.000030481238,0.0005266332,0.99413234,0.000022078082,0.0018102619,0.000005508714],"about_ca_topic_score_codex":0.0014162348,"about_ca_topic_score_gemma":0.001465727,"teacher_disagreement_score":0.0014162348,"about_ca_system_score_codex":0.00015201868,"about_ca_system_score_gemma":0.00019273991,"threshold_uncertainty_score":0.004136622},"labels":[],"label_agreement":null},{"id":"W3164836440","doi":"10.1016/j.bmcl.2021.128133","title":"Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"hERG; Chemistry; Nav1.5; Sulfonamide; Pharmacology; Long QT syndrome; Induced pluripotent stem cell; Sodium channel; Stereochemistry; Potassium channel; Biophysics; Biochemistry; QT interval; Internal medicine; Medicine","score_opus":0.005592460836350857,"score_gpt":0.22444076009289113,"score_spread":0.21884829925654026,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3164836440","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.947314,0.02423145,0.009852356,0.0006726956,0.00027697254,0.00031346126,0.00084326416,0.00030074723,0.01619498],"genre_scores_gemma":[0.96955305,0.01439918,0.0056938804,0.00036608693,0.00009543602,0.00013358396,0.0012437972,0.00002665805,0.008488345],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998871,0.000020076619,0.000008795988,0.000017051843,0.000031163763,0.000035857265],"domain_scores_gemma":[0.9999262,0.000013077555,0.000018779954,0.0000057118314,0.000015071392,0.000021112313],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035869487,0.0005871503,0.00034931736,0.0002644599,0.00015321415,0.00033261444,0.00035654736,0.0002830156,0.0020880974],"category_scores_gemma":[0.00026181337,0.00016737753,0.00022908257,0.00018469877,0.0002146717,0.0002814917,0.00033948023,0.0005528698,0.0004855544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011165419,0.0003764331,0.0008578468,0.0004556546,0.00005943749,0.00064948556,0.00017579553,0.0017197563,0.9235275,0.0027024427,0.0022567096,0.06610238],"study_design_scores_gemma":[0.0013129119,0.011094315,0.008652246,0.00013473647,0.00020547681,0.0021625871,0.00015654587,0.006926809,0.89554477,0.00096521905,0.0727462,0.00009822397],"about_ca_topic_score_codex":0.00062991795,"about_ca_topic_score_gemma":0.0021137805,"teacher_disagreement_score":0.0020880974,"about_ca_system_score_codex":0.00033359346,"about_ca_system_score_gemma":0.00028315998,"threshold_uncertainty_score":0.0069853663},"labels":[],"label_agreement":null},{"id":"W3165295814","doi":"10.1016/j.bmcl.2021.128147","title":"Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Carbonic anhydrase; In vitro; Enzyme; Cytotoxicity; Cell culture; Cancer cell; Biochemistry; Pharmacology; Cancer; Stereochemistry; Cancer research; Internal medicine; Biology","score_opus":0.00480229126075558,"score_gpt":0.19912559108835437,"score_spread":0.1943232998275988,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3165295814","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9796102,0.007933582,0.0031780906,0.00024265058,0.00011173998,0.00008313358,0.00029784575,0.00021804059,0.008324693],"genre_scores_gemma":[0.98985565,0.0043836585,0.0015938767,0.00006741182,0.000032188535,0.00003962438,0.000390703,0.000019862673,0.0036170844],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999281,0.000013712952,0.0000050028875,0.0000090065805,0.00002203146,0.000022052565],"domain_scores_gemma":[0.9999577,0.000007813128,0.000009995241,0.000004772773,0.000005917242,0.000013710481],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017815473,0.00032182506,0.00034886008,0.00026762593,0.0001599717,0.00022149367,0.00042142623,0.00031407183,0.0009457231],"category_scores_gemma":[0.00013337434,0.00014261695,0.0001411955,0.0002548103,0.0001626686,0.0002076062,0.00022071725,0.00045148534,0.00023987709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007406036,0.00012051544,0.000285215,0.00015452072,0.000041972635,0.00024478487,0.00009179328,0.0017417867,0.97038984,0.0017012347,0.0008797263,0.023607923],"study_design_scores_gemma":[0.0002215391,0.002424638,0.0016170637,0.000010627043,0.00007371363,0.0003763791,0.000019104758,0.0023333179,0.97777253,0.000118164775,0.015017316,0.000015566193],"about_ca_topic_score_codex":0.0009012324,"about_ca_topic_score_gemma":0.0020911999,"teacher_disagreement_score":0.0009457231,"about_ca_system_score_codex":0.00036345996,"about_ca_system_score_gemma":0.00019925949,"threshold_uncertainty_score":0.003163755},"labels":[],"label_agreement":null},{"id":"W3169947271","doi":"10.1016/j.bmcl.2021.128208","title":"Synthesis of NVS-BPTF-1 and evaluation of its biological activity","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"BP (Canada); Université du Québec à Montréal","funders":"","keywords":"Bromodomain; PHD finger; Transcription factor; Epigenetics; Chromatin; Chromatin remodeling; Chemistry; Cell biology; Transcription (linguistics); Biochemistry; Biology; Zinc finger; Gene","score_opus":0.02592907694340892,"score_gpt":0.2681060589966914,"score_spread":0.24217698205328245,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3169947271","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96703655,0.0030568703,0.018997097,0.00023354757,0.00014121352,0.00023123737,0.0024338292,0.00026381353,0.0076057715],"genre_scores_gemma":[0.9770353,0.0015180915,0.008777762,0.000070731956,0.000018118235,0.00009714271,0.003177182,0.000037986956,0.009267653],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998982,0.000008406116,0.0000068460295,0.000019423656,0.000022465962,0.000044801953],"domain_scores_gemma":[0.99993384,0.000010058169,0.000011951369,0.0000075792104,0.000016778227,0.000019755691],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016007242,0.00027541065,0.00027660534,0.00027230152,0.00023206025,0.0002001079,0.00040415407,0.00030885206,0.0021517947],"category_scores_gemma":[0.00023828348,0.000096781114,0.00024001526,0.00032875096,0.00014396031,0.0002963343,0.0001427405,0.00049891265,0.0007594096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036598428,0.00018281657,0.00022276535,0.00016091234,0.000014759579,0.0002471947,0.000051578176,0.0014225454,0.98389566,0.000572348,0.0003993717,0.012464066],"study_design_scores_gemma":[0.000020301966,0.00042355305,0.00038837604,0.000008277114,0.000010185433,0.00015318161,0.0000125418765,0.0006140511,0.992054,0.00007959685,0.0062261927,0.00000966608],"about_ca_topic_score_codex":0.0012360357,"about_ca_topic_score_gemma":0.0008918021,"teacher_disagreement_score":0.0021517947,"about_ca_system_score_codex":0.00034712185,"about_ca_system_score_gemma":0.00041287625,"threshold_uncertainty_score":0.007198453},"labels":[],"label_agreement":null},{"id":"W3178755463","doi":"10.1016/j.bmcl.2021.128241","title":"Are heterobivalent GRPR- and VPAC1R-bispecific radiopeptides suitable for efficient in vivo tumor imaging of prostate carcinomas?","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"In vivo; Chemistry; Positron emission tomography; Receptor; Cancer research; Molecular imaging; Prostate; Peptide; Pet imaging; Radioligand; Nuclear medicine; Internal medicine; Medicine; Biochemistry; Cancer; Biology","score_opus":0.019366964312235006,"score_gpt":0.2687956416288371,"score_spread":0.24942867731660212,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3178755463","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9530643,0.012593039,0.025973177,0.0016931127,0.000119463984,0.000078634504,0.00021952704,0.00020851447,0.0060502645],"genre_scores_gemma":[0.9869615,0.00335467,0.0065711415,0.00054780825,0.000035271154,0.0000399975,0.00021249878,0.000047345435,0.002229836],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998276,0.00004293459,0.0000067399365,0.00003410629,0.00002632902,0.00006221524],"domain_scores_gemma":[0.99990916,0.000023475397,0.000029391775,0.0000112045545,0.000011969334,0.000014754988],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045803885,0.00020199669,0.00029961576,0.000100337274,0.00011225808,0.00051317475,0.00034693858,0.00074253615,0.0013972537],"category_scores_gemma":[0.00044016464,0.00021096773,0.00015239979,0.000119781405,0.00031425455,0.00080811634,0.00016865387,0.0004327542,0.0007703647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034908453,0.000026878864,0.0004687623,0.00012376346,0.000013135051,0.000116240946,0.00003861836,0.00023106538,0.9858791,0.0011110973,0.00026054634,0.011381673],"study_design_scores_gemma":[0.000067037436,0.0005611132,0.004761625,0.000019443014,0.000036491485,0.001859992,0.000105002044,0.0015233908,0.977449,0.00077176956,0.01282242,0.000022804055],"about_ca_topic_score_codex":0.00044372494,"about_ca_topic_score_gemma":0.000446836,"teacher_disagreement_score":0.0013972537,"about_ca_system_score_codex":0.00027730665,"about_ca_system_score_gemma":0.00016005395,"threshold_uncertainty_score":0.004674256},"labels":[],"label_agreement":null},{"id":"W3180808017","doi":"10.1016/j.bmcl.2021.128255","title":"Biologically active metabolites in drug discovery","year":2021,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Drug discovery; Drug; Biological activity; Active metabolite; Drug development; Lead compound; Computational biology; Pharmacology; Metabolite; Biochemistry; In vitro; Biology","score_opus":0.12473688721997371,"score_gpt":0.44280691025526087,"score_spread":0.31807002303528714,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3180808017","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0002182888,0.9955161,0.00079148175,0.00039450394,0.00053749577,0.000011632462,0.000031232616,0.00002014467,0.0024791071],"genre_scores_gemma":[0.0021709988,0.99279493,0.00081958895,0.0004560571,0.0006478087,0.000019055005,0.00006135669,0.000004533023,0.003025652],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99973065,0.00006586097,0.000024511974,0.000038801794,0.00010828245,0.000031784384],"domain_scores_gemma":[0.9997694,0.00011013205,0.00003724744,0.0000133169015,0.0000462157,0.000023662818],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008181565,0.0012140936,0.0015124953,0.0021517293,0.00025847348,0.0012384977,0.00080513436,0.001078529,0.0055324226],"category_scores_gemma":[0.000665703,0.00043103122,0.00044729753,0.002115017,0.0007269837,0.0013879105,0.0011886633,0.0022504334,0.0040945318],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000114556125,0.00013044024,0.000105870335,0.009154301,0.000068169036,0.0002473051,0.000037375143,0.00055687665,0.005810042,0.010600076,0.027555281,0.94561976],"study_design_scores_gemma":[0.000044132983,0.0001719176,0.0003587495,0.0014446187,0.00007520107,0.00073787355,0.000024866053,0.00019454565,0.001965068,0.005389951,0.98957765,0.000015452559],"about_ca_topic_score_codex":0.00045757517,"about_ca_topic_score_gemma":0.00095545285,"teacher_disagreement_score":0.0055324226,"about_ca_system_score_codex":0.00058178906,"about_ca_system_score_gemma":0.000855654,"threshold_uncertainty_score":0.018507779},"labels":[],"label_agreement":null},{"id":"W3181121764","doi":"10.1016/j.bmcl.2021.128252","title":"A microtubule-localizing activity-based sensing fluorescent probe for imaging hydrogen peroxide in living cells","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Molecular Sensors and Ion Detection","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Institutes of Health; Agilent Technologies","keywords":"Chemistry; Hydrogen peroxide; Microtubule; Reactive oxygen species; Live cell imaging; Fluorescence; Biophysics; Fluorescence microscope; Cell biology; Oxidative stress; Subcellular localization; Fluorescence-lifetime imaging microscopy; Cell; Biochemistry; Biology","score_opus":0.0077816203043157605,"score_gpt":0.20985009594428364,"score_spread":0.20206847563996788,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3181121764","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9041965,0.0032262073,0.08100543,0.0009963177,0.00011489467,0.0001311713,0.00043484368,0.0009132194,0.008981503],"genre_scores_gemma":[0.9599899,0.0013276297,0.03095046,0.00028801215,0.000034004857,0.000101026504,0.00042863886,0.000056392277,0.006823902],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999325,0.000009720107,0.0000025636816,0.00002171702,0.000015775726,0.000017644334],"domain_scores_gemma":[0.9999597,0.000007079197,0.000009479455,0.0000040002956,0.0000067636934,0.000012864437],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016707265,0.00028233702,0.00019995398,0.00017644778,0.0003152956,0.00024819482,0.0005640459,0.00055488094,0.00092788],"category_scores_gemma":[0.00010087066,0.00015920143,0.00015145123,0.00018744661,0.0001935351,0.00033414224,0.00029503164,0.0004548593,0.00036448895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00004119754,0.000015372052,0.000043266115,0.00004168344,0.0000033002805,0.00005069506,0.00001739848,0.000067013534,0.99524754,0.00034685424,0.00023899459,0.003886627],"study_design_scores_gemma":[0.00000990058,0.000096454845,0.00027958807,0.0000023982495,0.000007641432,0.000117724725,0.000008521446,0.0011393668,0.99498075,0.000045803838,0.0033073835,0.000004593207],"about_ca_topic_score_codex":0.0005986759,"about_ca_topic_score_gemma":0.00088877877,"teacher_disagreement_score":0.00092788,"about_ca_system_score_codex":0.00043583885,"about_ca_system_score_gemma":0.00022334034,"threshold_uncertainty_score":0.0031622648},"labels":[],"label_agreement":null},{"id":"W3195795839","doi":"10.1016/j.bmcl.2021.128327","title":"Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis; Concordia University","funders":"","keywords":"Chemistry; Pharmacophore; HeLa; Tubulin; Lead compound; Structure–activity relationship; In vitro; Microtubule; A549 cell; Microtubule polymerization; Stereochemistry; Cancer cell; Cell culture; Isoquinoline; Antimitotic Agent; Cancer; Colchicine; Biochemistry; Cell biology; Biology","score_opus":0.0741659436902818,"score_gpt":0.2929779442530617,"score_spread":0.21881200056277988,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3195795839","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98980415,0.003639081,0.0034640078,0.00012692183,0.00002247112,0.00017768331,0.0004715048,0.00005057227,0.002243659],"genre_scores_gemma":[0.9931952,0.001963808,0.0020210587,0.000050579903,0.0000090465455,0.000045654277,0.0006605869,0.000007805931,0.0020463816],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999349,0.00001370358,0.000004347161,0.000013400289,0.000015097074,0.00001856816],"domain_scores_gemma":[0.9999436,0.000009333586,0.000012389781,0.000005831603,0.000016224083,0.000012577021],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024276275,0.00021003844,0.00023134935,0.00025550753,0.0001450617,0.0002443565,0.00041744212,0.00017645584,0.0010850225],"category_scores_gemma":[0.00014168941,0.000101214646,0.00022151606,0.000140914,0.00015405298,0.00014141649,0.00011406744,0.00029979294,0.00024247475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00073723024,0.00049251487,0.0004988683,0.00014657024,0.00001967459,0.00017116884,0.00005367519,0.0020173618,0.987015,0.0004033637,0.00016725059,0.008277279],"study_design_scores_gemma":[0.0005373108,0.018103793,0.008308645,0.000026313393,0.00018518402,0.0007323395,0.00007747401,0.0069568134,0.95377785,0.00021195442,0.011046856,0.000035370267],"about_ca_topic_score_codex":0.001000291,"about_ca_topic_score_gemma":0.0017495587,"teacher_disagreement_score":0.0010850225,"about_ca_system_score_codex":0.0002719261,"about_ca_system_score_gemma":0.000268046,"threshold_uncertainty_score":0.003629744},"labels":[],"label_agreement":null},{"id":"W3214558115","doi":"10.1016/j.bmcl.2021.128441","title":"Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; McGill University Health Centre; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Antiandrogen; Vorinostat; Enzalutamide; Chemistry; Histone deacetylase; Cancer research; Histone deacetylase inhibitor; Androgen receptor; HeLa; Prostate cancer; Biochemistry; Cell; Histone; Androgen; Biology; Cancer; Gene; Genetics","score_opus":0.006017437053869335,"score_gpt":0.2248244756253679,"score_spread":0.21880703857149855,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3214558115","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9646609,0.0043498543,0.01300944,0.00033533262,0.00020016027,0.000085445536,0.0005985834,0.00048961304,0.01627058],"genre_scores_gemma":[0.9874691,0.0008913138,0.0053760046,0.0001193135,0.000013559924,0.000048042388,0.00030490354,0.000027502889,0.0057503353],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999149,0.000007535665,0.0000038539097,0.000023243867,0.000020305666,0.000030252902],"domain_scores_gemma":[0.9999765,0.0000032439764,0.0000061795254,0.0000022636023,0.0000035364574,0.0000081942735],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008281568,0.00038765586,0.00022079892,0.00018694717,0.00016908284,0.00036804925,0.00045019796,0.00037157437,0.0016065195],"category_scores_gemma":[0.00006270009,0.00017412826,0.0001904313,0.00016671,0.00016688382,0.000246629,0.0002042931,0.0003596636,0.0004967757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011352074,0.00001425976,0.000051139756,0.000032400927,0.000011672914,0.000045190973,0.000011758813,0.00012607324,0.99602425,0.0005269678,0.00013786432,0.0029048966],"study_design_scores_gemma":[0.00001620955,0.000118256336,0.00029531383,0.0000016500154,0.000016714575,0.00007357654,0.00000927452,0.00051761244,0.9948198,0.000042365114,0.0040826406,0.000006583114],"about_ca_topic_score_codex":0.00055078854,"about_ca_topic_score_gemma":0.0011021822,"teacher_disagreement_score":0.0016065195,"about_ca_system_score_codex":0.00048656095,"about_ca_system_score_gemma":0.000119945085,"threshold_uncertainty_score":0.005374372},"labels":[],"label_agreement":null},{"id":"W4205254622","doi":"10.1016/j.bmcl.2003.10.067","title":"Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Subgenomic mRNA; NS5B; Chemistry; Polymerase; Hepatitis C virus; RNA polymerase; Virology; RNA-dependent RNA polymerase; Enzyme; Virus; RNA; Biochemistry; Hepacivirus; Biology; Gene","score_opus":0.013655437631392792,"score_gpt":0.2600341722963538,"score_spread":0.246378734664961,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4205254622","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.956715,0.02095024,0.010675984,0.00047844,0.00022672633,0.00037573423,0.00045595408,0.00016644367,0.009955616],"genre_scores_gemma":[0.9655136,0.018496668,0.0067613423,0.00024761638,0.000089269925,0.00017700177,0.0004968258,0.000021825192,0.008195824],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991214,0.000024230383,0.000005732378,0.0000092182945,0.000022772045,0.000025957108],"domain_scores_gemma":[0.9999336,0.000014397152,0.000012700439,0.0000069207927,0.000013658889,0.000018592498],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036344922,0.0005257735,0.000285656,0.0003136661,0.0001427888,0.00025794763,0.00027315467,0.0003016502,0.0016340036],"category_scores_gemma":[0.0002267457,0.00018485541,0.0002761779,0.00017294285,0.00019732853,0.00022289083,0.00023228319,0.00033240204,0.00036760498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000809149,0.00017793817,0.00030206135,0.0002475561,0.00004285718,0.0003286471,0.00008666789,0.0016303941,0.9468811,0.0019906352,0.000930832,0.046572182],"study_design_scores_gemma":[0.00053301593,0.0040374743,0.002098774,0.000030807067,0.00006805382,0.00052175025,0.000032292242,0.0027412344,0.96332586,0.00040662402,0.026175078,0.000028990062],"about_ca_topic_score_codex":0.0004301895,"about_ca_topic_score_gemma":0.0013291067,"teacher_disagreement_score":0.0016340036,"about_ca_system_score_codex":0.0002469292,"about_ca_system_score_gemma":0.0002973843,"threshold_uncertainty_score":0.0054662824},"labels":[],"label_agreement":null},{"id":"W4210517447","doi":"10.1016/j.bmcl.2022.128588","title":"Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Genentech; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Sussex; Wellcome Trust; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; McGill University; Universidade Estadual de Campinas; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Kinome; Effector; Chemistry; Drug discovery; Kinase; Membrane permeability; Computational biology; Biochemistry; Biology; Membrane","score_opus":0.011624379180687879,"score_gpt":0.22204439695360603,"score_spread":0.21042001777291816,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4210517447","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8893307,0.020426787,0.059761092,0.001214533,0.0002632043,0.0011776828,0.003269403,0.00091609935,0.023640508],"genre_scores_gemma":[0.9367279,0.009538567,0.043314856,0.00036310693,0.000038449387,0.000304428,0.0016630313,0.00005341993,0.007996391],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99981743,0.000039506765,0.000011201528,0.0000406542,0.00005471993,0.000036537192],"domain_scores_gemma":[0.99993145,0.000010533993,0.00002037135,0.000009772033,0.000010261906,0.000017564935],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033905104,0.0005604049,0.00036558637,0.00033944318,0.00014876187,0.00033759087,0.00046857612,0.00036677782,0.0017647964],"category_scores_gemma":[0.00018651667,0.00026387456,0.00021948725,0.00020875824,0.00020628181,0.00046772,0.00031170575,0.0007107869,0.00069962116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029480868,0.00019294498,0.00012818459,0.00028419174,0.00002162715,0.00027156304,0.000056836343,0.0027843558,0.97173667,0.0020932157,0.0006629129,0.021472676],"study_design_scores_gemma":[0.0003523118,0.002290004,0.0009283795,0.000029425692,0.000032029136,0.0008129736,0.000021093629,0.004104903,0.96715117,0.00048410063,0.02375916,0.000034331326],"about_ca_topic_score_codex":0.0003652986,"about_ca_topic_score_gemma":0.0010097764,"teacher_disagreement_score":0.0017647964,"about_ca_system_score_codex":0.0005204493,"about_ca_system_score_gemma":0.00031755178,"threshold_uncertainty_score":0.00590384},"labels":[],"label_agreement":null},{"id":"W4224289790","doi":"10.1016/j.bmcl.2022.128744","title":"Arabinonucleic acids containing C5-propynyl modifications form stable hybrid duplexes with RNA that are efficiently degraded by E. coli RNase H","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Oligonucleotide; Propynyl; Chemistry; Nucleic acid; Nuclease; RNase H; RNA; DNA; RNase P; Phosphoramidite; Combinatorial chemistry; Oligomer; Stereochemistry; Oligonucleotide synthesis; Chemical synthesis; Biochemistry; In vitro; Gene; Organic chemistry","score_opus":0.00989550883106059,"score_gpt":0.20044006451509905,"score_spread":0.19054455568403847,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4224289790","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9911151,0.0004979964,0.0057641384,0.000047809404,0.000051702675,0.00003884298,0.00010366923,0.0002239089,0.0021568427],"genre_scores_gemma":[0.9940899,0.00011929497,0.0029312617,0.000049324666,0.000011788676,0.000030196254,0.00021097447,0.000063615065,0.0024935193],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997186,0.00006541088,0.000017142027,0.00007672055,0.000067995534,0.00005405094],"domain_scores_gemma":[0.99957746,0.00012170081,0.00011588909,0.000049788927,0.000034345205,0.00010081956],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038719826,0.0004416344,0.0002837332,0.00019463472,0.00021189284,0.00046837627,0.00025603766,0.0005651992,0.0018299208],"category_scores_gemma":[0.00047928648,0.00034352476,0.00019836362,0.0001238927,0.0003177683,0.00029902707,0.00023032767,0.0005682695,0.00076841295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007310132,0.000012395627,0.000060258037,0.000010373719,0.0000070479387,0.000021090156,0.00001806209,0.00006690725,0.9990025,0.00011558189,0.000030207546,0.0005825373],"study_design_scores_gemma":[0.000013798457,0.00019955318,0.000561631,0.000002110137,0.00000968455,0.000071790455,0.000012857945,0.00045520344,0.9975278,0.000039722407,0.0010979467,0.000008022842],"about_ca_topic_score_codex":0.00027061536,"about_ca_topic_score_gemma":0.0005959092,"teacher_disagreement_score":0.0018299208,"about_ca_system_score_codex":0.00026128994,"about_ca_system_score_gemma":0.0001626686,"threshold_uncertainty_score":0.006121695},"labels":[],"label_agreement":null},{"id":"W4231874606","doi":"10.1016/s0960-894x(03)00390-1","title":"Nicotinyl aspartyl ketones as inhibitors of caspase-3","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Aldehyde; Aspartic acid; Enzyme; Stereochemistry; Pyridine; Enzyme inhibitor; Caspase; Aldehyde dehydrogenase; Chemical synthesis; Apoptosis; Biochemistry; Programmed cell death; Medicinal chemistry; In vitro; Amino acid; Catalysis","score_opus":0.005188850052923172,"score_gpt":0.20945887353714684,"score_spread":0.20427002348422368,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4231874606","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9610899,0.025889019,0.002274166,0.0003706771,0.00024760404,0.00008576264,0.00023433827,0.00024030119,0.009568289],"genre_scores_gemma":[0.9864581,0.009152918,0.0009127496,0.00008183094,0.000020383985,0.000017479564,0.00017683442,0.000010454042,0.0031691892],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999052,0.000019856878,0.000011067344,0.000008437628,0.000023440696,0.000031871772],"domain_scores_gemma":[0.99995065,0.000011866661,0.000008786696,0.0000058106425,0.000008831692,0.0000140702],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021803408,0.00039728393,0.0002775926,0.0003042853,0.0001671219,0.00039307371,0.00036021724,0.00028911565,0.0009892635],"category_scores_gemma":[0.00015510064,0.00016850921,0.0001862492,0.00020486601,0.00017954099,0.00028585296,0.00018265356,0.0006837291,0.0002844027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00413961,0.00023473901,0.00039739514,0.0002167084,0.000048571495,0.00050649955,0.0000881244,0.0011218098,0.9552551,0.0014105957,0.0006051164,0.03597575],"study_design_scores_gemma":[0.0007278943,0.002605805,0.0017438312,0.00002072454,0.00007720151,0.0006649068,0.000046947556,0.0019112161,0.9839061,0.0003782263,0.007894176,0.000023029603],"about_ca_topic_score_codex":0.000903805,"about_ca_topic_score_gemma":0.0020536527,"teacher_disagreement_score":0.0009892635,"about_ca_system_score_codex":0.0004217978,"about_ca_system_score_gemma":0.00024169279,"threshold_uncertainty_score":0.003309369},"labels":[],"label_agreement":null},{"id":"W4232674400","doi":"10.1016/j.bmcl.2011.07.042","title":"1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NeurAxon (Canada)","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Chemistry; Indole test; Nitric oxide synthase; Pharmacology; Enos; Nitric oxide; In vivo; Hyperalgesia; Chemical synthesis; Migraine; Stereochemistry; Biochemistry; Enzyme; In vitro; Anesthesia; Nociception; Receptor; Organic chemistry; Medicine","score_opus":0.02098557094468683,"score_gpt":0.24889293861298756,"score_spread":0.22790736766830072,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4232674400","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9647261,0.015895672,0.0051702634,0.00028514295,0.00026546326,0.00009122333,0.0005788386,0.00021425865,0.012773024],"genre_scores_gemma":[0.9865362,0.0054931208,0.001897427,0.00010799099,0.000034442208,0.00003797824,0.00037198118,0.000018393159,0.005502464],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999356,0.000015905525,0.000004052234,0.00000773514,0.0000111039635,0.000025644245],"domain_scores_gemma":[0.99997354,0.0000051295324,0.0000056016306,0.0000027996014,0.0000038632325,0.000009108174],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018851362,0.00026126552,0.0002221381,0.00017166532,0.00013478505,0.00013565745,0.00041158532,0.00023731649,0.0014502109],"category_scores_gemma":[0.00008643888,0.0000932733,0.00013527807,0.00015305981,0.00012273484,0.000146322,0.00012218962,0.00035040252,0.00029352616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009816014,0.00020227862,0.00022211978,0.00019902828,0.000022957363,0.00041699185,0.00009992654,0.0011176002,0.97309047,0.0017601058,0.0010167992,0.020870024],"study_design_scores_gemma":[0.00023992061,0.0039303848,0.0024242331,0.000027220694,0.000072989256,0.0005121895,0.000039613846,0.0024102023,0.9707798,0.00020417002,0.019331938,0.0000272934],"about_ca_topic_score_codex":0.000775782,"about_ca_topic_score_gemma":0.0028933643,"teacher_disagreement_score":0.0014502109,"about_ca_system_score_codex":0.0002677229,"about_ca_system_score_gemma":0.00019085628,"threshold_uncertainty_score":0.0048514605},"labels":[],"label_agreement":null},{"id":"W4236456501","doi":"10.1016/j.bmcl.2009.09.043","title":"Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]","year":2009,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Combinatorial chemistry; Stereochemistry","score_opus":0.008833804408569308,"score_gpt":0.21603507630371105,"score_spread":0.20720127189514173,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4236456501","genre_codex":"editorial","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00015686903,0.005626825,0.0005574229,0.030659886,0.9518838,0.00007993701,0.0013057251,0.00035154074,0.009378101],"genre_scores_gemma":[0.00918649,0.03118064,0.004261049,0.087039314,0.19134873,0.0003627526,0.0056823627,0.0007188659,0.6702198],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9969176,0.0002644912,0.00042155193,0.00049261627,0.0013741861,0.0005295393],"domain_scores_gemma":[0.99375945,0.001022406,0.0004236852,0.000398808,0.0038033356,0.00059232453],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0020301444,0.003899104,0.004009343,0.003489292,0.003741652,0.00249882,0.00576894,0.007783596,0.11764896],"category_scores_gemma":[0.012885394,0.0017642044,0.0033739947,0.0031385005,0.0017195736,0.002422712,0.0021604698,0.006548751,0.07732631],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005689501,0.000018687357,0.00003661652,0.00030027307,0.00002053793,0.0003450309,0.00001252163,0.00008066608,0.00032144564,0.00051229005,0.99258196,0.005713142],"study_design_scores_gemma":[0.00007554649,0.00007026392,0.0014059943,0.00020008619,0.00008022204,0.0004691352,0.000037598344,0.00024648273,0.0021892376,0.0009644513,0.99418855,0.00007248894],"about_ca_topic_score_codex":0.02360146,"about_ca_topic_score_gemma":0.041165683,"teacher_disagreement_score":0.11764896,"about_ca_system_score_codex":0.0061325124,"about_ca_system_score_gemma":0.0035375904,"threshold_uncertainty_score":0.39357495},"labels":[],"label_agreement":null},{"id":"W4239460021","doi":"10.1016/s0960-894x(04)00293-8","title":"Discovery of a potent and selective $alpha;v$beta;3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Public Health Agency of Canada","keywords":"Neointima; Chemistry; Antagonist; In vivo; Integrin; Alpha (finance); BETA (programming language); Structure–activity relationship; Pharmacology; Selectivity; IC50; Stereochemistry; Receptor; In vitro; Biochemistry; Internal medicine; Stent; Surgery; Restenosis; Biology","score_opus":0.010484564362055753,"score_gpt":0.24721045795034077,"score_spread":0.23672589358828502,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4239460021","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9691195,0.0075327787,0.015189409,0.000556774,0.00010515437,0.00024952556,0.0006024062,0.0001874245,0.006457038],"genre_scores_gemma":[0.97840697,0.00481333,0.009790835,0.00038767362,0.000073180876,0.00016046932,0.001122249,0.000026999183,0.0052183187],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999033,0.0000144482265,0.000006202003,0.0000130976005,0.000020018098,0.000042904278],"domain_scores_gemma":[0.99996185,0.0000049434957,0.000007529467,0.000003551049,0.000007872804,0.000014268918],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193363,0.00043772627,0.0005021665,0.00031688283,0.0002423465,0.0002958804,0.00035276348,0.00037595973,0.0009090785],"category_scores_gemma":[0.00012295494,0.00023233499,0.00030637128,0.00019296425,0.00013066111,0.00016848062,0.00018582612,0.0006001493,0.00039015687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023265654,0.00016369714,0.00014696895,0.00006112057,0.00002114885,0.00016756743,0.000024820623,0.00018647416,0.98997366,0.00027767298,0.00037682723,0.008367448],"study_design_scores_gemma":[0.00032002176,0.00259164,0.002647194,0.000014680847,0.00012620482,0.0011243221,0.00002377489,0.0014386264,0.98125756,0.00014474492,0.010291515,0.000019745577],"about_ca_topic_score_codex":0.00055662345,"about_ca_topic_score_gemma":0.0015369457,"teacher_disagreement_score":0.0009090785,"about_ca_system_score_codex":0.00022320772,"about_ca_system_score_gemma":0.00033125273,"threshold_uncertainty_score":0.0030412078},"labels":[],"label_agreement":null},{"id":"W4240110582","doi":"10.1016/j.bmcl.2008.11.037","title":"Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Insulin-like growth factor; Insulin-Like Growth Factor Receptor; Tyrosine kinase; Growth factor receptor inhibitor; Growth factor receptor; Receptor tyrosine kinase; Receptor; Growth factor; Cancer; Insulin receptor; Insulin-like growth factor 1 receptor; Cancer research; Pharmacology; Insulin; Biochemistry; Endocrinology; Internal medicine; Insulin resistance; Biology; Medicine","score_opus":0.028639069714739666,"score_gpt":0.265503949998349,"score_spread":0.2368648802836093,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4240110582","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9208324,0.007585338,0.04139801,0.00087045855,0.00028173407,0.0010609166,0.0017974537,0.0006377144,0.025535947],"genre_scores_gemma":[0.9864151,0.0018660608,0.007665817,0.00013079906,0.00001475894,0.000112529386,0.0005096707,0.000036274057,0.0032489696],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989915,0.00001700492,0.000005369125,0.000019702025,0.00001818102,0.000040524206],"domain_scores_gemma":[0.9999373,0.00000847629,0.000013797374,0.0000074621726,0.000016290616,0.000016652066],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020740773,0.00050427514,0.00038845345,0.00034916936,0.00030498087,0.00028549563,0.00041818514,0.00040758826,0.0020908376],"category_scores_gemma":[0.00020107451,0.0001499616,0.00029316734,0.00024058805,0.00019351573,0.00021581398,0.00032564253,0.00044370204,0.0004818047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016393651,0.00045543825,0.001717776,0.0004746848,0.00006261643,0.0017415206,0.00028129347,0.007512923,0.9249884,0.0042664185,0.0028359422,0.054023676],"study_design_scores_gemma":[0.0005590482,0.0031813625,0.0019445379,0.000042081203,0.00007115605,0.00067767786,0.000054202043,0.0046900585,0.9697762,0.0006345887,0.018333992,0.00003501787],"about_ca_topic_score_codex":0.0017399399,"about_ca_topic_score_gemma":0.004341143,"teacher_disagreement_score":0.0020908376,"about_ca_system_score_codex":0.0006177777,"about_ca_system_score_gemma":0.00056050933,"threshold_uncertainty_score":0.0069945455},"labels":[],"label_agreement":null},{"id":"W4243083854","doi":"10.1016/j.bmcl.2007.11.043","title":"Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" altimg=\"si2.gif\" overflow=\"scroll\"><mml:mrow><mml:msubsup><mml:mrow><mml:mi mathvariant=\"bold\">S</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math> substrate binding pocket","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Stereochemistry; Enzyme; Pyrrole; Cleavage (geology); Peptide; Small molecule; Acetamide; Amyloid precursor protein; Ring (chemistry); IC50; Substrate (aquarium); Molecule; Biochemistry; In vitro; Alzheimer's disease; Organic chemistry","score_opus":0.01651461878575155,"score_gpt":0.2483380502681837,"score_spread":0.23182343148243215,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4243083854","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9668795,0.008571004,0.009385828,0.00050119084,0.0002169251,0.00036834643,0.0009027485,0.00029821883,0.012876286],"genre_scores_gemma":[0.9727495,0.0056745624,0.014279676,0.00025262928,0.000039179875,0.00009965336,0.0010715417,0.00007138252,0.0057618376],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99984396,0.000037262686,0.000017493358,0.000026482614,0.000035878296,0.000038933453],"domain_scores_gemma":[0.99990535,0.000021449492,0.000023469822,0.000010801457,0.000011203443,0.00002775715],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036680003,0.00055495073,0.00044322203,0.00022100637,0.00020230065,0.00030689075,0.0005543187,0.0003798934,0.0039953245],"category_scores_gemma":[0.00036450668,0.00027263947,0.00031778225,0.0002773844,0.00018144492,0.00036882405,0.00025241286,0.0007128405,0.0009421285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028011913,0.0005020377,0.00024517725,0.00027634797,0.00006401897,0.0005772872,0.00009867623,0.0021745812,0.958304,0.0010410711,0.0013030227,0.03261264],"study_design_scores_gemma":[0.001173733,0.00501761,0.0023570245,0.00005621319,0.00014853345,0.001069926,0.00006225474,0.004095803,0.9643345,0.00038686674,0.021240884,0.000056667694],"about_ca_topic_score_codex":0.0010847754,"about_ca_topic_score_gemma":0.0037895723,"teacher_disagreement_score":0.0039953245,"about_ca_system_score_codex":0.00030951822,"about_ca_system_score_gemma":0.00033111539,"threshold_uncertainty_score":0.013365686},"labels":[],"label_agreement":null},{"id":"W4243315597","doi":"10.1016/j.bmcl.2009.07.113","title":"C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCθ inhibitors: Part II","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Protein kinase C; Stereochemistry; Chemical synthesis; Pharmacology; In vitro; Biochemistry; Enzyme","score_opus":0.007540314342123414,"score_gpt":0.2224573929241986,"score_spread":0.2149170785820752,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4243315597","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8181684,0.12676048,0.010780044,0.00079231855,0.0005174132,0.0004902366,0.0009109217,0.0004192652,0.04116086],"genre_scores_gemma":[0.8979366,0.07676333,0.0036032167,0.00041550837,0.0002442847,0.00021795365,0.0009338686,0.000059529208,0.019825742],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998741,0.000023019062,0.0000085161355,0.000016033035,0.000025599882,0.00005271453],"domain_scores_gemma":[0.99996996,0.000005461495,0.000008139738,0.000005798438,0.0000042627407,0.0000063869497],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027965396,0.00054970576,0.00048348415,0.0004954897,0.00024435463,0.00028336365,0.000595629,0.00035225422,0.0037337826],"category_scores_gemma":[0.00014352458,0.00023154951,0.0003662467,0.00038289043,0.00022227454,0.00045172902,0.00028074445,0.0005411042,0.0012857346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017384934,0.00087851944,0.00040553333,0.0010330828,0.00008762531,0.0005952989,0.00017550024,0.005055574,0.8476415,0.005528178,0.0034128444,0.13344784],"study_design_scores_gemma":[0.0005805267,0.00734967,0.006434129,0.0001316375,0.00022374917,0.001627109,0.00009459086,0.004088446,0.9077122,0.00096662546,0.07068935,0.000101912665],"about_ca_topic_score_codex":0.0011485274,"about_ca_topic_score_gemma":0.0016349675,"teacher_disagreement_score":0.0037337826,"about_ca_system_score_codex":0.0004871122,"about_ca_system_score_gemma":0.0003383626,"threshold_uncertainty_score":0.012490749},"labels":[],"label_agreement":null},{"id":"W4244161199","doi":"10.1016/j.bmcl.2005.07.071","title":"Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Dipeptide; Amide; Cathepsin S; Cathepsin; Stereochemistry; Peptide bond; Selectivity; Enzyme inhibitor; Carboxamide; Chemical synthesis; Cathepsin K; Nitrogen atom; Hydrogen bond; Cathepsin B; Peptide; Enzyme; Biochemistry; In vitro; Organic chemistry; Molecule; Group (periodic table); Catalysis","score_opus":0.004706623060705814,"score_gpt":0.22575672099338567,"score_spread":0.22105009793267985,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4244161199","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9612562,0.01659585,0.0066326065,0.0004894578,0.00027319154,0.00021075825,0.00041630326,0.0002804139,0.0138451755],"genre_scores_gemma":[0.9852938,0.007721742,0.0022156606,0.00016799888,0.00007406462,0.00005892621,0.00025290644,0.000028087481,0.004186707],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99983895,0.000045500707,0.000014148983,0.000017380855,0.000022601236,0.000061306484],"domain_scores_gemma":[0.9999089,0.000026518654,0.000022920936,0.000010149913,0.0000113548485,0.000020196581],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006057226,0.00045690636,0.00036898514,0.00036397175,0.00020036219,0.0002606664,0.0005334899,0.0005246563,0.0018907152],"category_scores_gemma":[0.00027072555,0.00026953412,0.000387244,0.00018937276,0.00021677025,0.000528427,0.0002579941,0.00063593657,0.0005475075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0048998105,0.00040266896,0.00033836218,0.00044975601,0.00011060135,0.0010974938,0.00023758478,0.0039420244,0.941273,0.0027732535,0.0017038463,0.042771574],"study_design_scores_gemma":[0.0014822353,0.011992752,0.0018541889,0.000077278644,0.00020049258,0.0015382088,0.000088029956,0.0032944402,0.9573487,0.00049850927,0.021549338,0.00007578155],"about_ca_topic_score_codex":0.0007263017,"about_ca_topic_score_gemma":0.001342383,"teacher_disagreement_score":0.0018907152,"about_ca_system_score_codex":0.00030903114,"about_ca_system_score_gemma":0.00017613445,"threshold_uncertainty_score":0.006325066},"labels":[],"label_agreement":null},{"id":"W4244900174","doi":"10.1016/j.bmcl.2011.07.022","title":"1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NeurAxon (Canada)","funders":"","keywords":"Chemistry; Nitric oxide synthase; Indole test; Neuronal Nitric Oxide Synthase; Nitric oxide; Enzyme inhibitor; ATP synthase; Stereochemistry; Enzyme; Biochemistry; Pharmacology; Organic chemistry","score_opus":0.02098557094468683,"score_gpt":0.24889293861298756,"score_spread":0.22790736766830072,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4244900174","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96629167,0.015187915,0.0049404604,0.00024626617,0.00023227815,0.00008718351,0.00053351856,0.00019827732,0.012282412],"genre_scores_gemma":[0.988047,0.00488473,0.0016807459,0.00009270499,0.000028410625,0.0000340396,0.00033468875,0.000015909825,0.004881757],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99993634,0.00001530696,0.000004036639,0.000007843848,0.000010928183,0.000025498042],"domain_scores_gemma":[0.9999734,0.000005391121,0.0000056360964,0.0000027770595,0.0000037997272,0.000009025586],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018884137,0.000251125,0.0002143555,0.00017462409,0.00013695248,0.00013812995,0.00040731305,0.00023034107,0.0014112446],"category_scores_gemma":[0.000086257234,0.000091563816,0.00013780133,0.00015378394,0.000121485464,0.00014439336,0.0001233867,0.00032821263,0.0002694049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010030959,0.00020008502,0.00024546465,0.00020065332,0.0000242574,0.00043706672,0.00010158457,0.0011549263,0.972336,0.0018725934,0.0009928453,0.021431437],"study_design_scores_gemma":[0.00024102804,0.004097703,0.0026395053,0.000028544022,0.000075999735,0.0005535796,0.00004203545,0.0025771433,0.9705584,0.00021009891,0.018949088,0.000026915724],"about_ca_topic_score_codex":0.0008514333,"about_ca_topic_score_gemma":0.0031624762,"teacher_disagreement_score":0.0014112446,"about_ca_system_score_codex":0.0002773828,"about_ca_system_score_gemma":0.00019209449,"threshold_uncertainty_score":0.004721105},"labels":[],"label_agreement":null},{"id":"W4250302984","doi":"10.1016/s0960-894x(02)00607-8","title":"Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 1: aryloxypropanolaminomethylpiperidines","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Pharmacophore; Chemical synthesis; In vitro; In vivo; Structure–activity relationship; Agonist; Chinese hamster ovary cell; Stereochemistry; Combinatorial chemistry; Pharmacology; Biochemistry; Receptor","score_opus":0.017580968270466076,"score_gpt":0.22118722647441347,"score_spread":0.2036062582039474,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4250302984","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94570655,0.023473509,0.011207533,0.00073918374,0.00037767354,0.00031469116,0.0013246062,0.0005012137,0.016355019],"genre_scores_gemma":[0.958327,0.020083498,0.007724195,0.0005639499,0.00017139899,0.00033508852,0.0012455654,0.00004539993,0.011503899],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999163,0.000018208782,0.0000088751485,0.00001360692,0.00001479102,0.000028316907],"domain_scores_gemma":[0.99995816,0.000008851564,0.000013027236,0.000004933027,0.0000040198697,0.000011020069],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021262931,0.000539832,0.00041284988,0.00016690881,0.00013568177,0.00022342658,0.0005878275,0.00035600647,0.002953858],"category_scores_gemma":[0.00016428316,0.00023292433,0.00019965258,0.00020300652,0.00017077847,0.000285799,0.00025096393,0.0006508128,0.0009478683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016375307,0.00020530217,0.0001967074,0.00039001554,0.000042705462,0.00075006875,0.00012399863,0.0009138832,0.94612324,0.0012626161,0.0017392368,0.046614587],"study_design_scores_gemma":[0.0016016325,0.009330592,0.004064443,0.00005466219,0.00020622116,0.003482044,0.00006436942,0.002012365,0.9168289,0.0005447207,0.061738104,0.0000720561],"about_ca_topic_score_codex":0.0003023011,"about_ca_topic_score_gemma":0.00086532236,"teacher_disagreement_score":0.002953858,"about_ca_system_score_codex":0.00024819982,"about_ca_system_score_gemma":0.00017831023,"threshold_uncertainty_score":0.009881616},"labels":[],"label_agreement":null},{"id":"W4293005297","doi":"10.1016/j.bmcl.2022.128950","title":"Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of ‘first-in-kind’ inhibitors of serine/threonine kinase25","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Servier","keywords":"Chemistry; Serine; Threonine; Stereochemistry; Active site; Docking (animal); Enzyme; IC50; Crystal structure; Structure–activity relationship; Transferase; Biochemistry; Pharmacology; In vitro; Medicine; Organic chemistry","score_opus":0.007118769418076476,"score_gpt":0.22326565819280852,"score_spread":0.21614688877473204,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4293005297","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.903473,0.03498419,0.03700971,0.0014180959,0.00050605135,0.0007404814,0.0022150164,0.0006514614,0.019001855],"genre_scores_gemma":[0.9294044,0.021147918,0.027249236,0.00038215035,0.000042795644,0.00024844595,0.0038416411,0.00010350489,0.017579898],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998636,0.000015821737,0.00001262615,0.000021612512,0.000040954244,0.000045242858],"domain_scores_gemma":[0.9999318,0.000007947899,0.000015115235,0.0000071794384,0.000012550321,0.000025397163],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037540068,0.0005017768,0.00049885985,0.00020363696,0.00029283742,0.0007371342,0.0008986369,0.00041063846,0.0017676499],"category_scores_gemma":[0.00022151817,0.0003850053,0.0003453439,0.0002694103,0.00021531228,0.00037848594,0.00025307215,0.001043056,0.00096194167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010968511,0.0006995283,0.00087305595,0.00073082827,0.00014963158,0.0009505399,0.00024061716,0.017643088,0.916996,0.0063142176,0.007355067,0.046950586],"study_design_scores_gemma":[0.0005032115,0.0013746828,0.0010503449,0.000045344157,0.00009915671,0.000871505,0.00006530686,0.010725381,0.9244451,0.0003516564,0.060401592,0.00006674382],"about_ca_topic_score_codex":0.0020936083,"about_ca_topic_score_gemma":0.003248558,"teacher_disagreement_score":0.0020936083,"about_ca_system_score_codex":0.00091956294,"about_ca_system_score_gemma":0.0006592752,"threshold_uncertainty_score":0.006671965},"labels":[],"label_agreement":null},{"id":"W4293680673","doi":"10.1016/j.bmcl.2022.128952","title":"Identification of the gossypol derivatives as androgen receptor inhibitor","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China; McGill University","keywords":"LNCaP; Androgen receptor; Chemistry; Enzalutamide; Prostate cancer; Gossypol; Cancer research; Androgen; Cell growth; Cancer; Internal medicine; Endocrinology; Pharmacology; Biochemistry; Biology; Hormone; Medicine","score_opus":0.013656061513781046,"score_gpt":0.2688512947338543,"score_spread":0.2551952332200732,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4293680673","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.970792,0.015765294,0.003937602,0.00031247688,0.00007160833,0.0001511949,0.0014406907,0.00015353282,0.007375485],"genre_scores_gemma":[0.98036665,0.0083845025,0.004684048,0.00015969199,0.000024374594,0.00003518501,0.0012248459,0.000017616909,0.0051031136],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999664,0.0000047195995,0.0000018950432,0.0000057752604,0.000010814805,0.000010398484],"domain_scores_gemma":[0.99997103,0.000003176028,0.000007137298,0.0000035126502,0.0000050621643,0.000010168922],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000059913404,0.0003171004,0.0001878395,0.00039786551,0.00016091563,0.00025015598,0.00018317488,0.00016464715,0.0014326758],"category_scores_gemma":[0.00008413047,0.00014265584,0.00025894682,0.00028589956,0.0001548701,0.00018488274,0.00017365853,0.00039399226,0.00028722134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005389627,0.00008217372,0.00046213865,0.00018844621,0.000030219933,0.00033247715,0.000032300217,0.00039214443,0.9812406,0.0004781021,0.00036741776,0.015855087],"study_design_scores_gemma":[0.00006506738,0.0010738357,0.0044358303,0.000016162066,0.000084246334,0.00040139892,0.000025040701,0.0009314949,0.9790146,0.0001273146,0.013808041,0.000016880485],"about_ca_topic_score_codex":0.0008438179,"about_ca_topic_score_gemma":0.0017707834,"teacher_disagreement_score":0.0014326758,"about_ca_system_score_codex":0.00020760737,"about_ca_system_score_gemma":0.00027939386,"threshold_uncertainty_score":0.0047928095},"labels":[],"label_agreement":null},{"id":"W4294647335","doi":"10.1016/j.bmcl.2022.128971","title":"A guanidinium group is an effective mimic of the tertiary carbocation formed by isopentenyl diphosphate isomerase","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Carbocation; Chemistry; Isomerase; Stereochemistry; Pyrophosphate; Enzyme; Biochemistry; Medicinal chemistry","score_opus":0.003919314917581705,"score_gpt":0.1915226936019956,"score_spread":0.1876033786844139,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4294647335","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9910556,0.0006123726,0.004695915,0.00014655512,0.000083638966,0.000047751397,0.00007299505,0.00015138778,0.0031338006],"genre_scores_gemma":[0.99670035,0.00013015063,0.0024875326,0.000026252901,0.000009112205,0.000009675355,0.00005989638,0.000014162325,0.00056284515],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985445,0.000043402808,0.000009501735,0.000035100595,0.000025624464,0.00003182369],"domain_scores_gemma":[0.99987435,0.000025447052,0.000028669612,0.000023182578,0.000008303375,0.000039944895],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025752228,0.0002969299,0.00023293743,0.00012500356,0.00019686134,0.00022982378,0.0004286287,0.0003938586,0.0009258373],"category_scores_gemma":[0.00023549121,0.00015302844,0.00016465376,0.00008573167,0.0003021775,0.00022565784,0.00034448795,0.00047870594,0.00019806952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025273112,0.000024435005,0.00011241335,0.000034113724,0.0000052365804,0.0001765019,0.00001512754,0.00019888219,0.9965971,0.00072861253,0.0000644295,0.001790387],"study_design_scores_gemma":[0.00007339295,0.00077513047,0.00038259669,0.0000031634606,0.000011055387,0.00031405044,0.000007750144,0.0009215455,0.9953068,0.00010953406,0.0020856552,0.00000926455],"about_ca_topic_score_codex":0.00031643902,"about_ca_topic_score_gemma":0.00034787058,"teacher_disagreement_score":0.0009258373,"about_ca_system_score_codex":0.00027434557,"about_ca_system_score_gemma":0.00017077407,"threshold_uncertainty_score":0.0030972362},"labels":[],"label_agreement":null},{"id":"W4294957697","doi":"10.1016/j.bmcl.2022.128981","title":"Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; National Institutes of Health; Crohn's and Colitis Canada","keywords":"Chemistry; Stereochemistry; Chemical synthesis; In vivo; Agonist; Structure–activity relationship; Receptor; Trifluoromethyl; IC50; Pharmacology; In vitro; Biochemistry","score_opus":0.008953115048863113,"score_gpt":0.23168790994819324,"score_spread":0.22273479489933012,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4294957697","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9726213,0.0062864735,0.008345846,0.00034585496,0.00011504287,0.00023297171,0.00095839077,0.00012632349,0.010967742],"genre_scores_gemma":[0.9837314,0.00401135,0.004664146,0.00014429275,0.00005128315,0.00007688578,0.0006553663,0.000022590479,0.0066427323],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989164,0.000019176558,0.0000070335213,0.000015221788,0.000024097015,0.00004283264],"domain_scores_gemma":[0.9999262,0.000015220079,0.000014926394,0.000010214829,0.00001121259,0.00002228385],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018995146,0.00025845255,0.00030237203,0.00024240428,0.00022100404,0.00023476462,0.00043632564,0.0003385846,0.004131758],"category_scores_gemma":[0.00018983938,0.00016251978,0.00024060845,0.000247903,0.0001810614,0.00029289772,0.00019117082,0.00054854277,0.0006207435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031969754,0.00012047007,0.00011495203,0.00010169152,0.000020940111,0.00029669073,0.0000510297,0.0004619984,0.98979163,0.0011572436,0.0002674783,0.0072962325],"study_design_scores_gemma":[0.00011954836,0.0027871372,0.0024100346,0.00001684927,0.000052796197,0.00051803235,0.000029958115,0.0010139393,0.9808343,0.0002382644,0.011947895,0.00003114676],"about_ca_topic_score_codex":0.0004966685,"about_ca_topic_score_gemma":0.0010555122,"teacher_disagreement_score":0.004131758,"about_ca_system_score_codex":0.00025105366,"about_ca_system_score_gemma":0.00022384664,"threshold_uncertainty_score":0.013822138},"labels":[],"label_agreement":null},{"id":"W4317632796","doi":"10.1016/j.bmcl.2023.129150","title":"Thermal treatment affects aptamers’ structural profiles","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"","keywords":"Aptamer; Chemistry; Circular dichroism; Sonication; High-performance liquid chromatography; Elution; Chromatography; Biophysics; Analytical Chemistry (journal); Crystallography","score_opus":0.00992314456901641,"score_gpt":0.2574685674104764,"score_spread":0.24754542284146,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4317632796","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9921017,0.0008805512,0.0036030638,0.0000966666,0.00006521082,0.0000218471,0.00022591552,0.000115777664,0.0028892846],"genre_scores_gemma":[0.99717665,0.00016641327,0.00070850196,0.0000917965,0.000006407747,0.000016617483,0.00017423356,0.000039925017,0.0016194372],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99965954,0.00004798646,0.000023004071,0.000101861006,0.00007046547,0.00009716902],"domain_scores_gemma":[0.9996791,0.0001060643,0.00005772294,0.000041036757,0.000067337285,0.000048765363],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023229934,0.00027920696,0.00020256487,0.00017255478,0.00022751774,0.00033736858,0.0002094337,0.00044460833,0.0064249574],"category_scores_gemma":[0.0008672515,0.00024567638,0.0002500432,0.00019214633,0.00024402753,0.00038220556,0.00015884888,0.00058886263,0.0014362911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001695699,0.000020072512,0.00029429776,0.00002713654,0.00001133472,0.000034555873,0.000027820177,0.0002601276,0.9968959,0.00010712289,0.00010195889,0.0020501588],"study_design_scores_gemma":[0.000008544748,0.00017638972,0.0039359243,0.0000046865,0.000019656714,0.00014264055,0.00003076087,0.0011705679,0.9930093,0.00007187639,0.0014180471,0.000011627563],"about_ca_topic_score_codex":0.00038868142,"about_ca_topic_score_gemma":0.00048188117,"teacher_disagreement_score":0.0064249574,"about_ca_system_score_codex":0.00021050057,"about_ca_system_score_gemma":0.00015286801,"threshold_uncertainty_score":0.021493673},"labels":[],"label_agreement":null},{"id":"W4322505755","doi":"10.1016/j.bmcl.2023.129210","title":"Armeniaspirol analogues disrupt the electrical potential (ΔΨ) of the proton motive force","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Chemistry; Proteases; Membrane potential; Electrochemical gradient; Chemiosmosis; Biophysics; Transmembrane protein; Natural product; Mechanism of action; Biochemistry; Membrane; ATP synthase; Enzyme; In vitro; Biology; Receptor","score_opus":0.012102433753739776,"score_gpt":0.21834985229253737,"score_spread":0.20624741853879758,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4322505755","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99361634,0.00067487493,0.0007827995,0.00010118008,0.00003011545,0.00003360605,0.00038212285,0.000046734378,0.004332225],"genre_scores_gemma":[0.99648845,0.0006396703,0.000496304,0.00009566387,0.0000047207773,0.000014312713,0.00034092687,0.0000047988287,0.0019151295],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999474,0.000008349203,0.0000059550093,0.0000067157453,0.000011979055,0.000019682242],"domain_scores_gemma":[0.9999566,0.000007656508,0.000013168715,0.000004413037,0.000006324109,0.0000118312055],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006551947,0.00019121914,0.00017420464,0.00012558528,0.000114012415,0.0002372027,0.00025127112,0.00025299835,0.0018940486],"category_scores_gemma":[0.00015511306,0.00012120614,0.00013391966,0.000116650626,0.00012912009,0.00021830449,0.00015749737,0.00055238465,0.00029709245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005954228,0.00005509337,0.000115960895,0.0000612494,0.000014926631,0.000098305354,0.000015633057,0.00024274326,0.9947261,0.00025809987,0.00014104588,0.00367539],"study_design_scores_gemma":[0.00030027932,0.003016523,0.007024812,0.000022475677,0.000055070064,0.0005146331,0.00008715896,0.0011377342,0.9819287,0.00028049233,0.005614452,0.000017755478],"about_ca_topic_score_codex":0.0008468965,"about_ca_topic_score_gemma":0.0015493783,"teacher_disagreement_score":0.0018940486,"about_ca_system_score_codex":0.00017860187,"about_ca_system_score_gemma":0.0001619936,"threshold_uncertainty_score":0.0063362718},"labels":[],"label_agreement":null},{"id":"W4377131253","doi":"10.1016/j.bmcl.2023.129345","title":"[18F]ONO-8430506: A novel radioligand for PET imaging of autotaxin (ATX)","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Radioligand; Chemistry; Autotaxin; Potency; Radioligand Assay; Pet imaging; Pharmacology; Stereochemistry; Biochemistry; Receptor; Positron emission tomography; In vitro; Nuclear medicine; Lysophosphatidic acid; Medicine","score_opus":0.021097422483209578,"score_gpt":0.3009944322556821,"score_spread":0.27989700977247256,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4377131253","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.931749,0.014108382,0.019238621,0.0009879054,0.00043763453,0.00028248734,0.0011782548,0.00057569466,0.031442028],"genre_scores_gemma":[0.9451632,0.0080608465,0.027287818,0.000556478,0.00012581091,0.00022117935,0.0032385883,0.00015181613,0.015194209],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99980706,0.000054026757,0.0000071275435,0.000038005863,0.000023160555,0.00007063817],"domain_scores_gemma":[0.99994504,0.000010197054,0.0000090364665,0.0000064558058,0.000007684568,0.000021610087],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033926443,0.00060729403,0.00060669874,0.00034797768,0.00039905065,0.00060133764,0.0010484573,0.0010820801,0.0020327189],"category_scores_gemma":[0.00018049775,0.00029935822,0.00024011137,0.0004608896,0.00028084512,0.00053070753,0.0003750823,0.0008342671,0.0008646902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0022106115,0.00023520202,0.0006337374,0.0003559978,0.000049697315,0.0005880396,0.000070786264,0.0010426292,0.95712554,0.0013600718,0.003764589,0.032563068],"study_design_scores_gemma":[0.00041270824,0.0027095343,0.0038745308,0.00005582619,0.0001764565,0.0045678867,0.00005500405,0.0045521334,0.9322215,0.00028318772,0.051018648,0.00007256145],"about_ca_topic_score_codex":0.003606832,"about_ca_topic_score_gemma":0.0035875516,"teacher_disagreement_score":0.003606832,"about_ca_system_score_codex":0.000745313,"about_ca_system_score_gemma":0.0008403939,"threshold_uncertainty_score":0.0071716905},"labels":[],"label_agreement":null},{"id":"W4377141782","doi":"10.1016/j.bmcl.2023.129348","title":"Generation and structure-activity relationships of novel imidazo-thienopyridine based TLR7 agonists: application as payloads for immunostimulatory antibody drug-conjugates","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Chemistry; TLR7; In vivo; Pharmacology; In vitro; Linker; Biochemistry; Toll-like receptor; Receptor; Innate immune system; Biology","score_opus":0.02386460946453783,"score_gpt":0.2714027146778136,"score_spread":0.24753810521327574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4377141782","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900123,0.0028400824,0.0041694823,0.00010718997,0.000022993974,0.00010159436,0.00037794505,0.000062288455,0.0023060811],"genre_scores_gemma":[0.99354583,0.0016892853,0.0025506085,0.0000359115,0.000007146266,0.00003951659,0.00030333016,0.000007392461,0.0018210653],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999498,0.00000954848,0.0000046400064,0.0000089166615,0.000011144647,0.000015937016],"domain_scores_gemma":[0.99993217,0.0000118706985,0.000024835123,0.0000054452557,0.000011615481,0.000014106593],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014988627,0.00021838235,0.00014718104,0.00009454174,0.00008024112,0.00013582339,0.0002420576,0.00021816071,0.0013937849],"category_scores_gemma":[0.00015678952,0.00011125603,0.00012149299,0.00010935832,0.00009180101,0.00015798095,0.00013553229,0.00031521503,0.0003871944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025655687,0.00007942511,0.000101115744,0.000091663926,0.0000068980958,0.00006203776,0.000021436877,0.0005548847,0.99498945,0.00014419082,0.000081645536,0.003610606],"study_design_scores_gemma":[0.0000419009,0.0014509027,0.000827143,0.000005438613,0.000020116391,0.00013539688,0.00001333713,0.0010388528,0.9944089,0.000025193905,0.0020249481,0.000007814487],"about_ca_topic_score_codex":0.00024154142,"about_ca_topic_score_gemma":0.0006783844,"teacher_disagreement_score":0.0013937849,"about_ca_system_score_codex":0.00019901435,"about_ca_system_score_gemma":0.00012892977,"threshold_uncertainty_score":0.0046626925},"labels":[],"label_agreement":null},{"id":"W4378974497","doi":"10.1016/j.bmcl.2023.129351","title":"Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre Intégré de Santé et de Services Sociaux des Laurentides","funders":"","keywords":"Prodrug; Chemistry; Agonist; Pharmacology; Oral administration; Inflammatory bowel disease; Receptor; Biochemistry; Internal medicine; Medicine; Disease","score_opus":0.019207437432045327,"score_gpt":0.26341494154474976,"score_spread":0.24420750411270442,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4378974497","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95685554,0.014737249,0.013254977,0.0016347618,0.0004357081,0.00045084755,0.0014090284,0.00022298362,0.010998927],"genre_scores_gemma":[0.9657714,0.011533893,0.010009197,0.0007443429,0.00008240426,0.000119331235,0.0014286614,0.0000319288,0.010278769],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999633,0.000006912535,0.000002715282,0.0000059884937,0.000010160798,0.000010937787],"domain_scores_gemma":[0.9999683,0.0000060265143,0.000006017612,0.0000024860296,0.0000042734628,0.000012938283],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625875,0.00036099367,0.0003121286,0.00019196337,0.00008694986,0.0002923013,0.00028669523,0.00045502998,0.0019167088],"category_scores_gemma":[0.0001524017,0.00014381116,0.00030013523,0.00009407859,0.00014510086,0.0002390287,0.00019344728,0.0007459046,0.0005411704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001187389,0.0003196459,0.00041478328,0.000512501,0.000056182103,0.0018825928,0.00007959799,0.0013943855,0.9141601,0.0027266294,0.0023180249,0.074948154],"study_design_scores_gemma":[0.0022743614,0.015435296,0.00369694,0.00015868884,0.00023845109,0.006840311,0.00008302581,0.006809298,0.9181037,0.001057927,0.04525386,0.00004809516],"about_ca_topic_score_codex":0.00022024004,"about_ca_topic_score_gemma":0.00039772157,"teacher_disagreement_score":0.0019167088,"about_ca_system_score_codex":0.00018388835,"about_ca_system_score_gemma":0.00022853348,"threshold_uncertainty_score":0.0064120293},"labels":[],"label_agreement":null},{"id":"W4379878813","doi":"10.1016/j.bmcl.2023.129371","title":"Amphiphilic tribasic galactosamines potentiate rifampicin in Gram-negative bacteria at low Mg++/Ca++concentrations","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Amphiphile; Bacteria; Tobramycin; Acinetobacter baumannii; Rifampicin; Gram-negative bacteria; Antibiotics; Microbiology; Biochemistry; Escherichia coli; Pseudomonas aeruginosa; Organic chemistry; Biology","score_opus":0.008827058954648938,"score_gpt":0.23186822233558044,"score_spread":0.2230411633809315,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4379878813","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9946814,0.0016613686,0.00067696266,0.00012469996,0.000045364617,0.000038674072,0.00015967661,0.00007302647,0.0025387034],"genre_scores_gemma":[0.9973085,0.0004830917,0.0005343083,0.00005980937,0.000017367945,0.000014856938,0.0001204052,0.000016613214,0.001445034],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9997608,0.00006345986,0.000021788735,0.000020841004,0.00006206198,0.00007103875],"domain_scores_gemma":[0.9996872,0.00008836589,0.00006439684,0.00003276358,0.000033452063,0.0000938095],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018089732,0.00035724335,0.00034821432,0.00015163417,0.000108832966,0.00022249101,0.0001653326,0.0003321689,0.0015613856],"category_scores_gemma":[0.0003824195,0.00017723319,0.0001768979,0.00012275462,0.0002712058,0.00016106054,0.00028767737,0.00035953434,0.00039397593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028966964,0.000016764943,0.000046455065,0.00003424294,0.0000023097734,0.000029250545,0.000014303185,0.000023925062,0.9988306,0.000023847477,0.000028199109,0.0006604735],"study_design_scores_gemma":[0.00003254081,0.0006904155,0.0021815659,0.000009253068,0.00000897991,0.00008887289,0.000027177277,0.00018378117,0.99584585,0.000018211036,0.00090846623,0.0000049073788],"about_ca_topic_score_codex":0.000967009,"about_ca_topic_score_gemma":0.0015792812,"teacher_disagreement_score":0.0015613856,"about_ca_system_score_codex":0.00014135029,"about_ca_system_score_gemma":0.00018760932,"threshold_uncertainty_score":0.005223334},"labels":[],"label_agreement":null},{"id":"W4380742410","doi":"10.1016/j.bmcl.2023.129376","title":"Synchrotron radiation circular dichroism spectroscopy of oligonucleotides at millimolar concentrations","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Circular dichroism; Chemistry; Nucleic acid; Synchrotron radiation; Spectroscopy; Analytical Chemistry (journal); Oligonucleotide; DNA; Spectral line; Synchrotron; Molar concentration; Crystallography; Chromatography; Optics; Biochemistry","score_opus":0.005592655031672959,"score_gpt":0.22054627128889967,"score_spread":0.2149536162572267,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4380742410","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98300606,0.0009384851,0.012294366,0.00021926181,0.000044939836,0.00003663048,0.00048475768,0.00010656861,0.0028689955],"genre_scores_gemma":[0.97616756,0.0011918903,0.016275298,0.00042689234,0.000023048615,0.00013345043,0.001645415,0.000048980408,0.004087462],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99959487,0.00015989496,0.000026485106,0.00007554041,0.000083379986,0.000059812515],"domain_scores_gemma":[0.9992841,0.00036664668,0.00008722528,0.00007490503,0.000129406,0.000057835547],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00064831553,0.00026157958,0.00034101907,0.00028157598,0.0003538204,0.00022405676,0.00027052715,0.00050473196,0.0016523423],"category_scores_gemma":[0.00076923287,0.00023571719,0.00015382736,0.00061152707,0.00023857992,0.00018897846,0.00013257691,0.0007829249,0.000439325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014946933,0.000033604614,0.00019516036,0.00003188574,0.000005758609,0.000025338144,0.000052288044,0.00013706714,0.9984819,0.000095169446,0.000076041295,0.0007163227],"study_design_scores_gemma":[0.000026538477,0.00043938454,0.0017482135,0.000008742418,0.000013206222,0.00008411355,0.0000541406,0.0011417557,0.9948614,0.000101966165,0.0015103664,0.000010092408],"about_ca_topic_score_codex":0.0003681363,"about_ca_topic_score_gemma":0.0005494559,"teacher_disagreement_score":0.0016523423,"about_ca_system_score_codex":0.0002261778,"about_ca_system_score_gemma":0.00025387135,"threshold_uncertainty_score":0.0055276155},"labels":[],"label_agreement":null},{"id":"W4386163400","doi":"10.1016/j.bmcl.2023.129456","title":"Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Capsid; Chemistry; ADME; Potency; Chemotype; Hepatitis B virus; Viral replication; Virology; Structure–activity relationship; Stereochemistry; Small molecule; Computational biology; Virus; Biochemistry; In vitro; Biology; Gene","score_opus":0.06049670974653201,"score_gpt":0.33791795828966104,"score_spread":0.277421248543129,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386163400","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9810951,0.002732883,0.0077725286,0.00027550722,0.00008322792,0.00047588424,0.0006497477,0.000101292666,0.0068138707],"genre_scores_gemma":[0.98330164,0.0016863048,0.0088828765,0.00019616644,0.000017270146,0.00008850123,0.0005659308,0.000013578964,0.005247844],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999428,0.000010432238,0.00000520175,0.000009978939,0.000009891769,0.000021696977],"domain_scores_gemma":[0.99994516,0.000006690626,0.000011225836,0.00000539408,0.000010058591,0.00002147368],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013537006,0.00023647783,0.00017762365,0.00022245706,0.00015276397,0.00021852752,0.00031035152,0.00018627051,0.001891086],"category_scores_gemma":[0.00014100055,0.000121730365,0.00013323592,0.00017606375,0.00011365442,0.000118551245,0.00019411428,0.00034045143,0.00049305503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00066236465,0.0002284549,0.00027411865,0.00011510891,0.000009309548,0.0003414613,0.00005367119,0.001182805,0.977229,0.0005514647,0.00032013876,0.0190321],"study_design_scores_gemma":[0.0004557825,0.0100928135,0.0029218385,0.000034330733,0.000054646996,0.0008669059,0.000049018337,0.0031509153,0.9686816,0.00019915309,0.013459068,0.00003400022],"about_ca_topic_score_codex":0.0007007883,"about_ca_topic_score_gemma":0.0016680722,"teacher_disagreement_score":0.001891086,"about_ca_system_score_codex":0.00023037841,"about_ca_system_score_gemma":0.00030752135,"threshold_uncertainty_score":0.006326258},"labels":[],"label_agreement":null},{"id":"W4387035713","doi":"10.1016/j.bmcl.2023.129488","title":"Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Institut National de la Recherche Scientifique; Structural Genomics Consortium; Université du Québec à Montréal","funders":"","keywords":"Chemistry; CTGF; Hippo signaling pathway; CYR61; Linker; Stereochemistry; Effector; Flufenamic acid; Transcription factor; Cell biology; Cancer research; Biochemistry; Growth factor; Receptor; Gene; Biology","score_opus":0.00926279662882393,"score_gpt":0.2278643272578555,"score_spread":0.21860153062903157,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4387035713","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94229513,0.020156318,0.017921684,0.0010707248,0.0003345323,0.000728685,0.0026121507,0.00053720415,0.014343571],"genre_scores_gemma":[0.96955544,0.007310321,0.0116669135,0.0003004443,0.000038984246,0.00027501883,0.0031537593,0.00002255422,0.0076765465],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998838,0.000014038848,0.000008696667,0.000022811848,0.00002428948,0.00004631762],"domain_scores_gemma":[0.9999441,0.0000054207044,0.000012241494,0.0000063025354,0.000009296669,0.000022616789],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025305792,0.0005963868,0.00047087914,0.00032808905,0.00024266024,0.00035689832,0.0004899732,0.00049238343,0.0015308048],"category_scores_gemma":[0.00016233996,0.00024233357,0.0004084105,0.00022662054,0.00021419655,0.00029121983,0.000248108,0.0008391312,0.0005453465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00083133,0.00025634447,0.0003509931,0.00018155754,0.000054928383,0.00038467487,0.00004943524,0.0011554204,0.965606,0.0009706381,0.000813528,0.029345255],"study_design_scores_gemma":[0.00047468126,0.002609654,0.0017085477,0.000019014391,0.00010144922,0.0010508174,0.000023160548,0.0017028599,0.96413267,0.00014295011,0.027996806,0.000037427937],"about_ca_topic_score_codex":0.0010550453,"about_ca_topic_score_gemma":0.0020594138,"teacher_disagreement_score":0.0015308048,"about_ca_system_score_codex":0.00043873154,"about_ca_system_score_gemma":0.00052213646,"threshold_uncertainty_score":0.0051210523},"labels":[],"label_agreement":null},{"id":"W4387563398","doi":"10.1016/j.bmcl.2023.129506","title":"Total and chemoenzymatic synthesis of the lipodepsipeptide rhizomide A","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Depsipeptide; Chemistry; Thioester; Thioesterase; Stereochemistry; Chemical synthesis; Combinatorial chemistry; Substrate specificity; Substrate (aquarium); Total synthesis; Enzyme; Biosynthesis; Biochemistry; In vitro","score_opus":0.008181373573612987,"score_gpt":0.2080184430268584,"score_spread":0.19983706945324542,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4387563398","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94380885,0.002476857,0.024189077,0.00022446227,0.00012241896,0.0002583577,0.0019034639,0.00016143468,0.026855132],"genre_scores_gemma":[0.9805902,0.0018852302,0.008135733,0.00005567468,0.000014078697,0.000050325423,0.000748598,0.000032222677,0.00848806],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991393,0.000009963246,0.00000806156,0.00001770639,0.0000149632815,0.00003529213],"domain_scores_gemma":[0.99995387,0.0000053757008,0.000008335931,0.0000068171826,0.000007281637,0.00001832979],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102611215,0.00044252718,0.00020688945,0.0002671357,0.00020655595,0.0003026668,0.00030650158,0.00024778128,0.0019023048],"category_scores_gemma":[0.000107856344,0.00010347216,0.00023894325,0.00029144535,0.0001968711,0.00029653808,0.0004697552,0.0006141762,0.0009829177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023082331,0.000074411364,0.00017632522,0.00016393709,0.000020065956,0.00031917228,0.00006903718,0.0010776484,0.9795315,0.0013368785,0.00023818767,0.016761938],"study_design_scores_gemma":[0.000026720629,0.00026954905,0.00056231266,0.000008342404,0.000015980575,0.00017347718,0.000030164965,0.00048981427,0.9917047,0.00016812704,0.0065368507,0.000014009897],"about_ca_topic_score_codex":0.0014059873,"about_ca_topic_score_gemma":0.0015317459,"teacher_disagreement_score":0.0019023048,"about_ca_system_score_codex":0.00035964613,"about_ca_system_score_gemma":0.00075992936,"threshold_uncertainty_score":0.0063638687},"labels":[],"label_agreement":null},{"id":"W4388406638","doi":"10.1016/j.bmcl.2023.129540","title":"Corrigendum to “Cytotoxicity, anti-tumor effects and structure–activity relationships of nickel and palladium S,C,S pincer complexes against double and triple-positive and triple-negative breast cancer (TNBC) cells” [Bioorg. Med. Chem. Lett. 43(2021)128107]","year":2023,"lang":"en","type":"erratum","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Pincer movement; Cytotoxicity; Palladium; Triple-negative breast cancer; Stereochemistry; Nickel; Cancer research; Breast cancer; Cancer; In vitro; Biochemistry; Internal medicine; Organic chemistry; Catalysis; Medicine","score_opus":0.02966707629350463,"score_gpt":0.2526726610297187,"score_spread":0.22300558473621407,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4388406638","genre_codex":"editorial","genre_gemma":"editorial","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"editorial","genre_consensus":"editorial","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00014829209,0.0036372042,0.0003588116,0.02637426,0.9582744,0.00005973393,0.0010025256,0.00032425267,0.009820414],"genre_scores_gemma":[0.007079379,0.017248593,0.0018407922,0.053512666,0.24578877,0.00022475819,0.0038183392,0.00059479586,0.6698919],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.9964485,0.00030846446,0.00044766426,0.0005619803,0.0017569666,0.00047630988],"domain_scores_gemma":[0.99075997,0.0015780072,0.00045554788,0.0005483481,0.005908502,0.00074962917],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002304713,0.0031214072,0.0036344358,0.0036188785,0.0037603476,0.0029738164,0.0045854114,0.0069399592,0.11522163],"category_scores_gemma":[0.01299325,0.0015388832,0.0030147817,0.0027953747,0.0015478508,0.002171589,0.002157394,0.0058125313,0.072601095],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000040155624,0.000015281965,0.000029741605,0.00019931962,0.000011974001,0.00021621502,0.000011499087,0.00005228428,0.00029552862,0.0003518202,0.9939231,0.004853117],"study_design_scores_gemma":[0.000032996773,0.000054919226,0.00084699254,0.00011823937,0.0000529786,0.00028960322,0.00002897326,0.0002072707,0.0015495003,0.0005854524,0.9961903,0.00004275409],"about_ca_topic_score_codex":0.023506993,"about_ca_topic_score_gemma":0.036114898,"teacher_disagreement_score":0.11522163,"about_ca_system_score_codex":0.0060462523,"about_ca_system_score_gemma":0.0038455692,"threshold_uncertainty_score":0.3854547},"labels":[],"label_agreement":null},{"id":"W4390674535","doi":"10.1016/j.bmcl.2024.129617","title":"Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of North Carolina at Chapel Hill; Genentech; McGill University; North Carolina General Assembly; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Genome Canada; North Carolina Biotechnology Center; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Chemistry; Selectivity; Benzoic acid; Stereochemistry; Chemical synthesis; Combinatorial chemistry; Structure–activity relationship; In vitro; Biochemistry; Catalysis","score_opus":0.005188772081600863,"score_gpt":0.24852107837837276,"score_spread":0.24333230629677188,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4390674535","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98827493,0.0037103998,0.004731691,0.00012260281,0.000025777268,0.00007823602,0.00025743453,0.000057587033,0.0027413827],"genre_scores_gemma":[0.9869039,0.0023281914,0.00825051,0.000058383735,0.000019119032,0.000043745164,0.00044437972,0.000011814727,0.001939928],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999306,0.000016373398,0.000005169251,0.000009603896,0.000020067424,0.000018291576],"domain_scores_gemma":[0.99994504,0.0000063273656,0.000018182202,0.000006313237,0.000009571347,0.000014537482],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012816074,0.00028178573,0.00021530548,0.00011539691,0.00009879927,0.00015525897,0.0002037323,0.00017993635,0.00074727705],"category_scores_gemma":[0.000094504336,0.00010338783,0.00016959857,0.000115844756,0.00013901168,0.00014597221,0.0001254261,0.0003953026,0.0003429181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010639549,0.000031366664,0.00015621132,0.000049839608,0.0000054090087,0.00008000002,0.000017061277,0.0002886167,0.9954116,0.00010867942,0.000047297573,0.0036974093],"study_design_scores_gemma":[0.00003734274,0.0006689007,0.0019254753,0.0000037759673,0.000015426036,0.0003073481,0.00001083041,0.00071302475,0.99263316,0.00003057745,0.003646224,0.0000079529955],"about_ca_topic_score_codex":0.0003151354,"about_ca_topic_score_gemma":0.0009614616,"teacher_disagreement_score":0.00074727705,"about_ca_system_score_codex":0.0002031126,"about_ca_system_score_gemma":0.00020703649,"threshold_uncertainty_score":0.0024998188},"labels":[],"label_agreement":null},{"id":"W4391560449","doi":"10.1016/j.bmcl.2024.129646","title":"Potential of several triazene derivatives against DENGUE viruses","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec; Université du Québec à Trois-Rivières","funders":"","keywords":"Dengue fever; Dengue virus; Virology; Aedes aegypti; Aedes albopictus; Flavivirus; Serotype; Biology; Virus; Ecology; Larva","score_opus":0.009292820986618528,"score_gpt":0.252654808664427,"score_spread":0.2433619876778085,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4391560449","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9580839,0.020550655,0.0038716474,0.00039078484,0.00022983279,0.00016903323,0.00068026903,0.0001790409,0.015844863],"genre_scores_gemma":[0.9815431,0.008226858,0.0024042816,0.00015448201,0.000031613046,0.000053632757,0.00048648875,0.00001546482,0.007084124],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999597,0.000010684743,0.00000380514,0.000005935215,0.0000073440624,0.000012414274],"domain_scores_gemma":[0.9999701,0.0000056722483,0.0000056019903,0.000004291387,0.000005953747,0.000008376135],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011673097,0.0003191406,0.00021565684,0.00030465427,0.00019114275,0.00015800158,0.00025387015,0.00021393261,0.004315155],"category_scores_gemma":[0.00011046034,0.00009739261,0.00030468532,0.00019944216,0.00014891967,0.0001879133,0.00018886082,0.00046174912,0.0004919176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012106585,0.0002100391,0.000272344,0.00057209114,0.00004202176,0.00029511482,0.000109541885,0.0010297003,0.97079766,0.0010812666,0.00062345096,0.02375619],"study_design_scores_gemma":[0.0001651945,0.005068545,0.0012321229,0.00005485222,0.000091184535,0.0003067826,0.0000793319,0.0010088535,0.97418875,0.0002498679,0.017530387,0.000024143163],"about_ca_topic_score_codex":0.00043024076,"about_ca_topic_score_gemma":0.00077508774,"teacher_disagreement_score":0.004315155,"about_ca_system_score_codex":0.00010590224,"about_ca_system_score_gemma":0.00017434357,"threshold_uncertainty_score":0.014435649},"labels":[],"label_agreement":null},{"id":"W4392204090","doi":"10.1016/j.bmcl.2024.129679","title":"Synthesis, SARS-CoV-2 main protease inhibition, molecular docking and in silico ADME studies of furanochromene-quinoline hydrazone derivatives","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Susquehanna University; Philadelphia Foundation","keywords":"Chemistry; Quinoline; In silico; ADME; Docking (animal); Hydrazone; Protease; Enzyme inhibitor; Stereochemistry; Combinatorial chemistry; Enzyme; Biochemistry; Pharmacology; In vitro; Organic chemistry","score_opus":0.0276328479882528,"score_gpt":0.3121634314609122,"score_spread":0.28453058347265936,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4392204090","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.971494,0.004129871,0.014115606,0.0003408193,0.00007899914,0.00039156748,0.0015581108,0.00019948554,0.007691492],"genre_scores_gemma":[0.98680645,0.0020718917,0.0063691987,0.000064751395,0.0000073794445,0.000069974245,0.0005517709,0.00001692805,0.0040414883],"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.99993753,0.000013045839,0.0000037894768,0.000012622099,0.000014535875,0.000018493894],"domain_scores_gemma":[0.9999559,0.00000904667,0.00000876244,0.0000075121798,0.00001051871,0.0000081842645],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017483984,0.00026428496,0.00031170275,0.00018318222,0.00019086049,0.00013817882,0.00032306326,0.00019564149,0.0022006982],"category_scores_gemma":[0.00014191751,0.0001671874,0.00025871978,0.00016887675,0.00012099712,0.00015548342,0.0001165839,0.00041732093,0.00045465317],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005664291,0.00040859779,0.00021626224,0.00034841648,0.000048792066,0.00031965633,0.0000881888,0.009812409,0.9706499,0.0014893567,0.00083807687,0.0152138835],"study_design_scores_gemma":[0.00020604688,0.0033956165,0.0013835307,0.000022959779,0.000076891585,0.000276014,0.00004010184,0.007912253,0.9775433,0.00016902838,0.008934777,0.000039451963],"about_ca_topic_score_codex":0.0012687648,"about_ca_topic_score_gemma":0.0022714422,"teacher_disagreement_score":0.0022006982,"about_ca_system_score_codex":0.0002908508,"about_ca_system_score_gemma":0.00025389894,"threshold_uncertainty_score":0.0073620677},"labels":[],"label_agreement":null},{"id":"W4392361112","doi":"10.1016/j.bmcl.2024.129682","title":"Self-assembly of amphiphilic helical-coiled peptide nanofibers and inhibition of fibril formation with curcumin","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Supramolecular Self-Assembly in Materials","field":"Materials Science","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Carleton University","funders":"Canada Foundation for Innovation; Carleton University","keywords":"Peptide; Amphiphile; Nanofiber; Fibril; Chemistry; Biophysics; Folding (DSP implementation); Peptide sequence; Self-assembly; Crystallography; Biochemistry; Nanotechnology; Materials science; Copolymer; Organic chemistry; Polymer","score_opus":0.005862614808736134,"score_gpt":0.21087540972929092,"score_spread":0.2050127949205548,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4392361112","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99573165,0.00068937615,0.002235985,0.000040135077,0.000016650025,0.000040988816,0.00010558353,0.00006156032,0.0010780906],"genre_scores_gemma":[0.9955954,0.00035914392,0.0027511138,0.000030242272,0.000006966656,0.000059144673,0.00011997173,0.000012128774,0.001065914],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989593,0.000019703617,0.000010651161,0.00002184126,0.000022033104,0.00002987924],"domain_scores_gemma":[0.99989283,0.000026782423,0.000033856766,0.0000089976265,0.000012216132,0.000025309806],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001551962,0.00025002842,0.00015214006,0.00015396472,0.00008869999,0.00010025684,0.00008573739,0.00019514163,0.0005744337],"category_scores_gemma":[0.00011911408,0.00012580738,0.00019024074,0.00006180978,0.0001229852,0.00013432124,0.00010693629,0.00022267291,0.00014339284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0000386791,0.00001410866,0.000029366942,0.00001880838,0.0000018845215,0.000014421229,0.0000058912897,0.000024871284,0.9994704,0.000013038937,0.000010391979,0.0003581492],"study_design_scores_gemma":[0.0000049705973,0.000148424,0.0011203211,0.0000019693014,0.0000031031666,0.00004259928,0.0000034416405,0.00028096684,0.9981201,0.0000068496324,0.00026549146,0.0000016962811],"about_ca_topic_score_codex":0.00035125136,"about_ca_topic_score_gemma":0.0008346372,"teacher_disagreement_score":0.0005744337,"about_ca_system_score_codex":0.00012865466,"about_ca_system_score_gemma":0.000103077735,"threshold_uncertainty_score":0.0019217134},"labels":[],"label_agreement":null},{"id":"W4394725739","doi":"10.1016/j.bmcl.2024.129745","title":"Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Réseau Québécois de Recherche sur les Médicaments","keywords":"Chemistry; Colchicine; Tubulin; Microtubule; Mechanism of action; Moiety; Stereochemistry; In vivo; Microtubule polymerization; Binding site; In vitro; Pharmacology; Biochemistry; Cell biology; Biology","score_opus":0.018650349097630952,"score_gpt":0.23458566654336416,"score_spread":0.21593531744573322,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4394725739","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9884992,0.0026107526,0.004905597,0.00012837455,0.000041088028,0.00007246913,0.0003014805,0.00009998737,0.0033410192],"genre_scores_gemma":[0.9914146,0.0017931133,0.0044266884,0.000070687296,0.000012518323,0.000045235556,0.00028180052,0.000009869687,0.0019454189],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999529,0.000011102207,0.0000036987474,0.000007654013,0.000009262644,0.000015303887],"domain_scores_gemma":[0.99994636,0.0000066797124,0.000022512213,0.0000033598374,0.000007779107,0.000013302323],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007652755,0.00032868577,0.00016207037,0.00011093674,0.000078661484,0.000105328785,0.00016319077,0.00016790039,0.0009949807],"category_scores_gemma":[0.00009026171,0.00008989587,0.00010408939,0.00012487751,0.00014783889,0.00010209451,0.00009300897,0.00022309835,0.00033536594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018742525,0.000038203823,0.00018698463,0.00009713846,0.000005253464,0.00010125269,0.00001682921,0.00029858667,0.99509215,0.00018389778,0.000073456235,0.0037189333],"study_design_scores_gemma":[0.000060613533,0.0015000736,0.0018745814,0.0000059099953,0.000014487451,0.00021248021,0.000015665568,0.00061847415,0.99121124,0.000028112958,0.0044497093,0.000008590181],"about_ca_topic_score_codex":0.00045496316,"about_ca_topic_score_gemma":0.0008141897,"teacher_disagreement_score":0.0009949807,"about_ca_system_score_codex":0.0001843657,"about_ca_system_score_gemma":0.00021641568,"threshold_uncertainty_score":0.0033285618},"labels":[],"label_agreement":null},{"id":"W4400036330","doi":"10.1016/j.bmcl.2024.129861","title":"Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Innovative Medicines Initiative; European Commission; Ono Pharmaceutical; Kungliga Tekniska Högskolan; UK Research and Innovation; European Federation of Pharmaceutical Industries and Associations; Diamond Light Source; McGill University","keywords":"Linker; Chemistry; Moiety; Stereochemistry; Ubiquitin ligase; Ligand (biochemistry); Ternary complex; Affinities; Plasma protein binding; Crystallography; Ubiquitin; Receptor; Biochemistry","score_opus":0.007706144983931077,"score_gpt":0.22052143702364715,"score_spread":0.21281529203971608,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400036330","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99295217,0.00039759045,0.0037119656,0.00006481306,0.00002809567,0.000036566893,0.00020082796,0.00011160014,0.0024964097],"genre_scores_gemma":[0.99563354,0.00028209973,0.0022426075,0.000065199216,0.0000052400856,0.000024882407,0.0001899684,0.00002662356,0.0015299163],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998853,0.000020910056,0.000011263683,0.000027264054,0.000024007908,0.000031285144],"domain_scores_gemma":[0.99988496,0.00001693735,0.000044705503,0.000015479098,0.000013614398,0.000024348185],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014712576,0.0003172782,0.00021316034,0.00009397225,0.0001163276,0.00021787363,0.00022297223,0.00021711197,0.0017984452],"category_scores_gemma":[0.00015376328,0.00014250331,0.00017988644,0.00013313344,0.00020641519,0.00021749672,0.00019122844,0.000501195,0.00063316827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037266169,0.000059922146,0.00029822843,0.00005149847,0.00001156142,0.000095588446,0.000020300857,0.0006154042,0.9946872,0.00038767778,0.000092082424,0.0033077467],"study_design_scores_gemma":[0.000035612018,0.0004890556,0.0007601108,0.0000031997247,0.000016130794,0.00018124245,0.000016377708,0.0008429108,0.9949167,0.000037013768,0.0026931695,0.000008531599],"about_ca_topic_score_codex":0.00039614577,"about_ca_topic_score_gemma":0.0005924025,"teacher_disagreement_score":0.0017984452,"about_ca_system_score_codex":0.00026989647,"about_ca_system_score_gemma":0.00025833995,"threshold_uncertainty_score":0.0060164332},"labels":[],"label_agreement":null},{"id":"W4400620475","doi":"10.1016/j.bmcl.2024.129883","title":"Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Université de Montréal; University of St Andrews","keywords":"Captopril; Chemistry; Carboxypeptidase; Enzyme inhibitor; Enzyme; ACE inhibitor; Dipeptidyl peptidase-4; Carboxypeptidase A; Biochemistry; Stereochemistry; Angiotensin-converting enzyme; Pharmacology; Endocrinology; Diabetes mellitus","score_opus":0.015936009477895918,"score_gpt":0.28265568144021913,"score_spread":0.2667196719623232,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400620475","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5995795,0.31807914,0.029463802,0.0069787838,0.0020464764,0.00029600444,0.000886618,0.0006586146,0.042011056],"genre_scores_gemma":[0.79989284,0.16043977,0.021641897,0.0023188845,0.0013105434,0.00014877824,0.0006278666,0.00014709991,0.013472244],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99989974,0.000017203576,0.000009708893,0.000020603988,0.00003001942,0.000022765182],"domain_scores_gemma":[0.9999168,0.000018342296,0.000018779223,0.000008322374,0.000023296729,0.000014508844],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044147696,0.00035447945,0.00036441162,0.0003116392,0.00019866115,0.0010292846,0.0005511992,0.000488683,0.0020594816],"category_scores_gemma":[0.00023875742,0.00019310541,0.00021019671,0.00020013328,0.00031293905,0.0009568057,0.0004126014,0.0007125136,0.0010047388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000571987,0.00019183838,0.00032571092,0.0015126561,0.000033700824,0.0008136385,0.0000998491,0.000638599,0.8872054,0.0053045824,0.00210397,0.10119799],"study_design_scores_gemma":[0.00028812676,0.003526108,0.0016546337,0.00028593198,0.00025806527,0.002151225,0.00013372739,0.0030785294,0.7252974,0.002486831,0.2607939,0.000045517154],"about_ca_topic_score_codex":0.00030372824,"about_ca_topic_score_gemma":0.0006758883,"teacher_disagreement_score":0.0020594816,"about_ca_system_score_codex":0.00033430124,"about_ca_system_score_gemma":0.00040094426,"threshold_uncertainty_score":0.006889701},"labels":[],"label_agreement":null},{"id":"W4404278113","doi":"10.1016/j.bmcl.2024.130026","title":"Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Research Council; Canadian Institutes of Health Research; Government of Saskatchewan; Genentech; Canada Foundation for Innovation; University of Saskatchewan","keywords":"Chemistry; Pharmacology; Tuberculosis; Stereochemistry; Pathology; Medicine","score_opus":0.010857402214461296,"score_gpt":0.26068609813746313,"score_spread":0.24982869592300183,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404278113","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9291331,0.04144992,0.013548168,0.0010114481,0.0002923029,0.00049834314,0.00069047004,0.0003333084,0.01304287],"genre_scores_gemma":[0.98137176,0.010278269,0.0042410577,0.00023521368,0.000049362603,0.00005443388,0.0004525182,0.000019607955,0.0032978496],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991584,0.000016588672,0.0000042868637,0.000008679778,0.000019211437,0.000035451016],"domain_scores_gemma":[0.99994266,0.000007354205,0.000010353974,0.0000034496086,0.00001151396,0.000024539931],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022751534,0.00035157765,0.00040162573,0.00030647058,0.00015820116,0.00037772037,0.00033830435,0.0002821597,0.0015491343],"category_scores_gemma":[0.00020932451,0.00023132618,0.00018460125,0.00013809123,0.00015961625,0.0001683629,0.00025691628,0.0006239188,0.00035545928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008719741,0.00033999584,0.0010788171,0.0003158807,0.00006972025,0.0006065525,0.000121688594,0.0016763936,0.90295655,0.0015954125,0.0015848813,0.0887821],"study_design_scores_gemma":[0.0017219846,0.009477614,0.008904932,0.00015378956,0.0002762023,0.0027812803,0.00011500239,0.0090019945,0.899737,0.00087156676,0.066901766,0.00005688125],"about_ca_topic_score_codex":0.000618775,"about_ca_topic_score_gemma":0.0029472162,"teacher_disagreement_score":0.0015491343,"about_ca_system_score_codex":0.000307151,"about_ca_system_score_gemma":0.0002676221,"threshold_uncertainty_score":0.005182326},"labels":[],"label_agreement":null},{"id":"W4404634902","doi":"10.1016/j.bmcl.2024.130033","title":"Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Cyclopentane; Carboxylic acid; Chemical synthesis; Drug discovery; Combinatorial chemistry; Stereochemistry; Biochemistry; In vitro","score_opus":0.006644499577710179,"score_gpt":0.22562844169402368,"score_spread":0.2189839421163135,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404634902","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91290575,0.042491376,0.014756709,0.0014723402,0.0006298135,0.00065862195,0.0015183169,0.00046656097,0.025100531],"genre_scores_gemma":[0.9491233,0.025196368,0.0084065925,0.0007221109,0.00015014109,0.00019243687,0.0015314025,0.00004295645,0.014634689],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999094,0.000014862209,0.000005594619,0.000014725205,0.000022679546,0.000032704203],"domain_scores_gemma":[0.99993706,0.000009728089,0.000013884634,0.0000045986167,0.0000125010165,0.000022323695],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025108957,0.00048212716,0.00035956863,0.0003036712,0.0001637644,0.00040825384,0.0003974512,0.00036892763,0.002514301],"category_scores_gemma":[0.00020142722,0.00021108886,0.0002487556,0.00016507033,0.0001997097,0.00023226059,0.00028871515,0.00065895147,0.0007591506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010219637,0.00029521945,0.0003480239,0.00040015558,0.000058859765,0.0006136137,0.000084981046,0.0017536998,0.92949533,0.0028601538,0.0025909082,0.060477104],"study_design_scores_gemma":[0.0010447636,0.0046634194,0.0031086674,0.00009252416,0.00014097196,0.0018002513,0.00006048286,0.003688509,0.90791214,0.0007522362,0.07666489,0.000071041075],"about_ca_topic_score_codex":0.00049479847,"about_ca_topic_score_gemma":0.0015921671,"teacher_disagreement_score":0.002514301,"about_ca_system_score_codex":0.00035505134,"about_ca_system_score_gemma":0.0002885506,"threshold_uncertainty_score":0.008411169},"labels":[],"label_agreement":null},{"id":"W4405235411","doi":"10.1016/j.bmcl.2024.130067","title":"Classifying covalent protein binders by their targeted binding site","year":2024,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Mitacs; Toronto Metropolitan University","keywords":"Covalent bond; Chemistry; Covalent binding; Folding (DSP implementation); Plasma protein binding; Protein folding; Combinatorial chemistry; Biochemistry; Biophysics; Biology; Organic chemistry","score_opus":0.035834978617091194,"score_gpt":0.3000774155342682,"score_spread":0.264242436917177,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405235411","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.004174084,0.98466545,0.0034873644,0.00032426175,0.00024908312,0.000076405195,0.000109846085,0.00004582067,0.006867683],"genre_scores_gemma":[0.02056928,0.9698173,0.004525728,0.0005555068,0.00018377427,0.00009613251,0.00025556397,0.000010839411,0.0039857775],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99975675,0.000028700817,0.000027777807,0.00004955927,0.000101171696,0.00003608448],"domain_scores_gemma":[0.9998585,0.00005069186,0.000035809393,0.00000839512,0.000034750778,0.000011806184],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004741374,0.00093972497,0.0011352964,0.0020550927,0.00020653981,0.00092140865,0.0007657048,0.0008807313,0.0014734785],"category_scores_gemma":[0.0004993739,0.00033369684,0.00041783747,0.0015501082,0.00052886514,0.0011960366,0.0004973126,0.0012740861,0.0012877518],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013353475,0.0001568969,0.000632057,0.01716035,0.00013907866,0.0005240394,0.000110743895,0.0013578768,0.07405659,0.013504513,0.0078002154,0.8844242],"study_design_scores_gemma":[0.000054704407,0.00048024394,0.0018122159,0.0019191786,0.00024433673,0.0034843674,0.000091391164,0.0008107576,0.054664332,0.0036347297,0.9327445,0.00005921255],"about_ca_topic_score_codex":0.00045888775,"about_ca_topic_score_gemma":0.0006870686,"teacher_disagreement_score":0.0020550927,"about_ca_system_score_codex":0.00053892226,"about_ca_system_score_gemma":0.00044320006,"threshold_uncertainty_score":0.004929304},"labels":[],"label_agreement":null},{"id":"W4405612338","doi":"10.1016/j.bmcl.2024.130078","title":"Diamino variants of piperazine-based tissue transglutaminase inhibitors","year":2024,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Blood properties and coagulation","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tissue transglutaminase; Chemistry; Piperazine; Enzyme inhibitor; Enzyme; Biochemistry; Pharmacology; Organic chemistry","score_opus":0.01016962413098943,"score_gpt":0.2369416655498164,"score_spread":0.22677204141882698,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405612338","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9724434,0.0055382685,0.011527084,0.00042847978,0.00017794824,0.000073011215,0.00030650207,0.00021859283,0.009286736],"genre_scores_gemma":[0.9904586,0.0017295297,0.0033280887,0.000110518486,0.000022043534,0.000024424833,0.0002471912,0.000019297988,0.0040602153],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.999902,0.000025216174,0.0000073712768,0.00001739522,0.000021494901,0.000026494887],"domain_scores_gemma":[0.99992895,0.0000101774785,0.000023493418,0.0000084133935,0.000010144667,0.00001879807],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558707,0.0003241783,0.00018507356,0.00010021994,0.00009852455,0.00018299471,0.0004514683,0.00024271719,0.0022157328],"category_scores_gemma":[0.00017977807,0.0001132333,0.00012275497,0.00013387573,0.00017237653,0.00029970577,0.00022167727,0.0006678578,0.00043909767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00076120236,0.000078612,0.00013904582,0.00014053493,0.000026794358,0.0002926425,0.00005458402,0.0010132556,0.98712116,0.001593071,0.00040695586,0.008372076],"study_design_scores_gemma":[0.00012099745,0.0023708018,0.00086756516,0.000017207205,0.000043006872,0.000908132,0.000037271242,0.0026765915,0.97786784,0.00028043656,0.014787767,0.000022343973],"about_ca_topic_score_codex":0.00034248523,"about_ca_topic_score_gemma":0.00046881358,"teacher_disagreement_score":0.0022157328,"about_ca_system_score_codex":0.00022797503,"about_ca_system_score_gemma":0.00009776694,"threshold_uncertainty_score":0.007412374},"labels":[],"label_agreement":null},{"id":"W4406161055","doi":"10.1016/j.bmcl.2025.130093","title":"Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases","year":2025,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Simon Fraser University","funders":"Crohn's and Colitis Canada; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; CH.I.L.D. Foundation; BC Children's Hospital","keywords":"Chemistry; Prodrug; Ulcerative colitis; Agonist; Prostaglandin E2; Pharmacology; Receptor; Colitis; Prostaglandin E2 receptor; Internal medicine; Biochemistry; Medicine","score_opus":0.014452068760240905,"score_gpt":0.26548993386510816,"score_spread":0.25103786510486725,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4406161055","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.92557895,0.027437475,0.028242143,0.00085664645,0.00059664814,0.00077079394,0.0013089326,0.0003358855,0.014872618],"genre_scores_gemma":[0.9500377,0.014672305,0.01673726,0.0005084518,0.0000831795,0.00023192818,0.001050136,0.000030380317,0.016648535],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999682,0.0000060840816,0.00000235931,0.000005463184,0.000005500317,0.000012434143],"domain_scores_gemma":[0.9999801,0.000003204782,0.0000049941805,0.0000018102616,0.0000038620756,0.0000060773755],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001364289,0.00034870647,0.00026215706,0.0002626657,0.000105988925,0.00020106454,0.00027139645,0.00032090102,0.0034487955],"category_scores_gemma":[0.00009675398,0.00014870995,0.00027272291,0.000108593085,0.00009449577,0.00024806662,0.00016389796,0.00046547613,0.0006266255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010957796,0.00036866497,0.0002599052,0.0006218442,0.000059184225,0.0008187579,0.000055059067,0.0016154335,0.8957578,0.0023353845,0.0015529414,0.09545918],"study_design_scores_gemma":[0.0013601441,0.013200996,0.0030956853,0.0001195266,0.00027876956,0.0022616584,0.00008049193,0.0048810607,0.89997756,0.0011414944,0.07355522,0.000047445832],"about_ca_topic_score_codex":0.00023587546,"about_ca_topic_score_gemma":0.0006040466,"teacher_disagreement_score":0.0034487955,"about_ca_system_score_codex":0.00016217673,"about_ca_system_score_gemma":0.00015628354,"threshold_uncertainty_score":0.011537313},"labels":[],"label_agreement":null},{"id":"W4407821252","doi":"10.1016/j.bmcl.2025.130137","title":"N-alkyl substituted armeniaspirol analogs show potent antibiotic activity and have low susceptibility to resistance","year":2025,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Alkyl; Antibiotics; Stereochemistry; Chemical synthesis; Antibacterial agent; Antibiotic resistance; Structure–activity relationship; Pharmacology; In vitro; Biochemistry; Organic chemistry","score_opus":0.006383591573283608,"score_gpt":0.21827430232307762,"score_spread":0.21189071074979401,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4407821252","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97919476,0.0036067003,0.004908257,0.00014624518,0.000038631966,0.000119094744,0.0008041951,0.00011028064,0.011071813],"genre_scores_gemma":[0.9886652,0.0020984132,0.0037627267,0.00013552116,0.000007997856,0.00004830119,0.00090991793,0.000017992501,0.004353876],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999206,0.0000138813475,0.000009630801,0.0000136997,0.00002073946,0.000021381502],"domain_scores_gemma":[0.9999,0.000011778569,0.000038068272,0.000014976577,0.000017352933,0.000017870678],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000075709286,0.00027348273,0.00019715533,0.00012627225,0.0000993207,0.0001796069,0.00020429643,0.00024009787,0.001876558],"category_scores_gemma":[0.00011872512,0.00009900118,0.00017425067,0.000154116,0.00014450657,0.00021450288,0.00016375986,0.00041010234,0.00049006264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017821012,0.00005748385,0.00022869106,0.0001194139,0.000009985176,0.00016024134,0.000016196942,0.00049372634,0.98714125,0.00019167004,0.000107196276,0.011295939],"study_design_scores_gemma":[0.00009611483,0.0033577061,0.0033526537,0.00002441935,0.000035567613,0.00087578304,0.000031729996,0.00071031164,0.97610474,0.00013919281,0.015252784,0.000019020858],"about_ca_topic_score_codex":0.0003360821,"about_ca_topic_score_gemma":0.0009133052,"teacher_disagreement_score":0.001876558,"about_ca_system_score_codex":0.00020696622,"about_ca_system_score_gemma":0.00022317366,"threshold_uncertainty_score":0.00627774},"labels":[],"label_agreement":null},{"id":"W4408082878","doi":"10.1016/j.bmcl.2025.130160","title":"Bulky substrates of isoleucine 2-epimerase: α-Neopentylglycine and NV-5138","year":2025,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Faculty of Graduate Studies, Dalhousie University; Natural Sciences and Engineering Research Council of Canada; Faculty of Medicine, Dalhousie University; Dalhousie University","keywords":"Chemistry; Isoleucine; Stereochemistry; Biochemistry; Amino acid; Leucine","score_opus":0.00297741010317542,"score_gpt":0.21767411952095234,"score_spread":0.2146967094177769,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4408082878","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99226975,0.0009791569,0.0028358109,0.00007507536,0.00003436558,0.00002828499,0.00038433724,0.000095619296,0.0032975543],"genre_scores_gemma":[0.9944741,0.00040401376,0.0022312398,0.000028573026,0.0000052643545,0.000014281424,0.0006201536,0.00003369298,0.0021886805],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99978334,0.00006012418,0.000021420567,0.000048705748,0.00004139339,0.000045058943],"domain_scores_gemma":[0.99985754,0.000033419492,0.00003159119,0.000023736873,0.000016892429,0.00003679336],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021741191,0.0004456152,0.0003514098,0.00013942107,0.00010066599,0.0002984503,0.00041146626,0.00032618566,0.0012135792],"category_scores_gemma":[0.0003118068,0.00016749743,0.000100329045,0.00017552519,0.00014308661,0.0003227545,0.0002299121,0.0004743831,0.0005425595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008366368,0.000056502697,0.0002352762,0.00005454699,0.000013177468,0.00020417692,0.000036321162,0.0005852099,0.99380445,0.00031274612,0.00012490063,0.0037360769],"study_design_scores_gemma":[0.000038479582,0.0003934254,0.00031324325,0.0000031805048,0.000006873423,0.0002040812,0.000015724183,0.00054019905,0.99695826,0.0000446236,0.0014754994,0.000006371133],"about_ca_topic_score_codex":0.00058787013,"about_ca_topic_score_gemma":0.00083847943,"teacher_disagreement_score":0.0012135792,"about_ca_system_score_codex":0.00033057856,"about_ca_system_score_gemma":0.00019356408,"threshold_uncertainty_score":0.004059851},"labels":[],"label_agreement":null},{"id":"W4412855726","doi":"10.1016/j.bmcl.2025.130352","title":"Discovery of the new active ingredient tigolaner, an allosteric modulator of the GABA-gated chloride channel for use as a spot-on ectoparasiticide in animal health","year":2025,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vétoquinol (Canada)","funders":"Boehringer Ingelheim","keywords":"Fipronil; Chemistry; hERG; Allosteric regulation; Pharmacology; Drug discovery; Lead compound; Allosteric modulator; Chloride channel; Computational biology; Stereochemistry; Biochemistry; In vitro; Biophysics; Enzyme; Biology; Potassium channel; Pesticide","score_opus":0.026712552695510827,"score_gpt":0.2778928117125626,"score_spread":0.25118025901705177,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412855726","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9488603,0.011700946,0.023344288,0.0021041255,0.00025814763,0.0002366699,0.0006519328,0.00037775762,0.012465807],"genre_scores_gemma":[0.9751369,0.0061652903,0.009606753,0.00059235713,0.00005256937,0.000046770972,0.0005320962,0.00002546155,0.007841889],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999641,0.000004099656,0.0000014198655,0.0000066897765,0.000011900991,0.000011707537],"domain_scores_gemma":[0.9999734,0.0000033668534,0.0000052915984,0.0000020725895,0.000005563447,0.000010261769],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501479,0.0002399109,0.00020021743,0.00019189458,0.00009988401,0.00031248826,0.00032323212,0.00039878176,0.0015451066],"category_scores_gemma":[0.00012746324,0.00009215387,0.0002990265,0.00008578499,0.00016719569,0.0002656233,0.00025073695,0.000563104,0.00042381018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020392366,0.000056739562,0.00012936896,0.00008922922,0.000014543561,0.00026938826,0.000032813954,0.00033222706,0.98008496,0.0010449083,0.00044633038,0.017295705],"study_design_scores_gemma":[0.0003358395,0.0033513648,0.0021080284,0.0000309167,0.00009604636,0.0015368582,0.00007228599,0.0033938393,0.95219904,0.0007034991,0.03614797,0.000024255809],"about_ca_topic_score_codex":0.00031566794,"about_ca_topic_score_gemma":0.00077052775,"teacher_disagreement_score":0.0015451066,"about_ca_system_score_codex":0.00028436634,"about_ca_system_score_gemma":0.00021895676,"threshold_uncertainty_score":0.005168855},"labels":[],"label_agreement":null},{"id":"W4412891602","doi":"10.1016/j.bmcl.2025.130353","title":"Design of a peripherally biased NPSR1 antagonist for neuropeptide S induced inflammation","year":2025,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"FPInnovations","funders":"","keywords":"Inflammation; Chemistry; Pharmacology; Immunology; Biology","score_opus":0.03765276527549502,"score_gpt":0.2701164883763682,"score_spread":0.23246372310087318,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412891602","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9344147,0.01540797,0.03303062,0.0012744525,0.00026760026,0.0014517262,0.001643306,0.00047387162,0.012035807],"genre_scores_gemma":[0.9521726,0.010267514,0.024221433,0.0008393045,0.000078512545,0.0006356642,0.0017232114,0.00004290214,0.01001884],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99985754,0.000026622196,0.000011018614,0.00003481785,0.000026847581,0.00004318803],"domain_scores_gemma":[0.9999356,0.000007195773,0.0000149409325,0.0000052241735,0.000013766636,0.00002334797],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023027016,0.0005186437,0.0007756227,0.00028345632,0.00019368464,0.00045750712,0.00074854924,0.00055371964,0.0019747992],"category_scores_gemma":[0.00018283774,0.0002363847,0.00037533947,0.00021759172,0.00021550327,0.00023326324,0.00025389652,0.0010912499,0.0009023292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006510686,0.00042275983,0.00010723174,0.00028119524,0.0000423347,0.00025255553,0.000052180843,0.0010346228,0.98187387,0.000610841,0.0007988353,0.013872427],"study_design_scores_gemma":[0.0020952641,0.01796367,0.002114528,0.000099220924,0.00031202333,0.002293236,0.00010883183,0.00950074,0.919764,0.00041407492,0.04523677,0.000097579854],"about_ca_topic_score_codex":0.00050000096,"about_ca_topic_score_gemma":0.0013938062,"teacher_disagreement_score":0.0019747992,"about_ca_system_score_codex":0.0003888102,"about_ca_system_score_gemma":0.0004025681,"threshold_uncertainty_score":0.0066063404},"labels":[],"label_agreement":null},{"id":"W4416295879","doi":"10.1016/j.bmcl.2025.130471","title":"Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors","year":2025,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Government of Ontario","keywords":"Transcription factor; Bromodomain; Drug discovery; Sulfonamide; Lymphoma; BCL6; Virtual screening; Structure–activity relationship; Transcription (linguistics); Drug","score_opus":0.004269112887691976,"score_gpt":0.21632286151044147,"score_spread":0.2120537486227495,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4416295879","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96885747,0.011971655,0.006570065,0.000557195,0.00016227039,0.00032565242,0.00069026276,0.00018545685,0.010680018],"genre_scores_gemma":[0.98352295,0.0067498744,0.0038938276,0.00017074047,0.000034656485,0.000078185214,0.00066842337,0.000011427427,0.0048698797],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99992704,0.000015580967,0.0000043985956,0.000008784753,0.00002272938,0.000021440284],"domain_scores_gemma":[0.9999535,0.0000061196815,0.0000109869625,0.0000027030555,0.00001027992,0.00001647823],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028414547,0.00037466933,0.00028011322,0.0002474168,0.00011342164,0.00034023466,0.0003954875,0.0003016795,0.0019717652],"category_scores_gemma":[0.00017130935,0.00017252253,0.00021894254,0.0001233594,0.00015065588,0.0002646834,0.00025500497,0.00047541023,0.00046361514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00091392203,0.00055356947,0.00045801335,0.0002607935,0.00004675435,0.0003836801,0.00009802026,0.003198452,0.9571513,0.0026703305,0.0010228065,0.03324235],"study_design_scores_gemma":[0.0017958403,0.013038822,0.0040793503,0.000063699285,0.00015454832,0.0012734075,0.0000846272,0.010824444,0.9279248,0.0008439915,0.0398698,0.00004672907],"about_ca_topic_score_codex":0.00038313234,"about_ca_topic_score_gemma":0.0014685238,"teacher_disagreement_score":0.0019717652,"about_ca_system_score_codex":0.00031851506,"about_ca_system_score_gemma":0.00025442624,"threshold_uncertainty_score":0.006596148},"labels":[],"label_agreement":null},{"id":"W51203826","doi":"10.1016/s0960-894x(03)00129-x","title":"Novel 5-aryl-1,3-dihydro-indole-2-thiones","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Thio-; Amide; Agonist; Aryl; Indole test; Stereochemistry; Chemical synthesis; In vivo; Structure–activity relationship; Carboxamide; Biological activity; Receptor; In vitro; Biochemistry; Organic chemistry; Alkyl","score_opus":0.005893981040753021,"score_gpt":0.20728588695434466,"score_spread":0.20139190591359163,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W51203826","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8465225,0.027843107,0.041264813,0.0021078603,0.0014814046,0.00044213078,0.0016734559,0.0012914087,0.07737344],"genre_scores_gemma":[0.9490557,0.010179321,0.0097808745,0.0004605915,0.00020953873,0.00018729574,0.00066705624,0.000052914304,0.029406885],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99991214,0.000019493273,0.0000055469477,0.00001542985,0.000014127515,0.000033164077],"domain_scores_gemma":[0.99994016,0.000008337821,0.000013768535,0.000007484916,0.000010531995,0.000019657638],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020430208,0.00050574954,0.00020347083,0.0003590011,0.00027161467,0.00028975614,0.00056780607,0.0003715967,0.0042280927],"category_scores_gemma":[0.0001230976,0.00016161744,0.00027956706,0.00019854281,0.0002652404,0.00038966382,0.00030988702,0.00054969604,0.0011996564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003493435,0.00024319961,0.00029438216,0.00040024248,0.00002464319,0.00091046427,0.00025431692,0.0012772282,0.96081483,0.007062201,0.0017768904,0.026592309],"study_design_scores_gemma":[0.00021175195,0.0044806693,0.004979158,0.00008782656,0.00005468086,0.0016940036,0.00021428746,0.003122225,0.8921424,0.0016704736,0.09127326,0.000069253],"about_ca_topic_score_codex":0.0005183072,"about_ca_topic_score_gemma":0.001458225,"teacher_disagreement_score":0.0042280927,"about_ca_system_score_codex":0.0003732645,"about_ca_system_score_gemma":0.00028810694,"threshold_uncertainty_score":0.014144361},"labels":[],"label_agreement":null},{"id":"W766425380","doi":"10.1016/j.bmcl.2015.05.079","title":"Computational insights into the suicide inhibition of Plasmodium falciparum Fk506-binding protein 35","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Atlantic Canada Opportunities Agency; Canada Foundation for Innovation; Compute Canada","keywords":"Plasmodium falciparum; Malaria; Chemistry; Plasmodium (life cycle); Molecular mechanics; Parasite hosting; Computational biology; Biology; Immunology; Molecular dynamics; Computational chemistry; Computer science","score_opus":0.01644647517236258,"score_gpt":0.2287923122128598,"score_spread":0.21234583704049723,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W766425380","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9565045,0.0011208705,0.018133007,0.00078259147,0.00008050304,0.00006220508,0.0006391073,0.0005083506,0.022168763],"genre_scores_gemma":[0.9916837,0.0002466332,0.0064502982,0.00010358458,0.000015835869,0.00004311628,0.0003252151,0.00002848693,0.0011030512],"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","domain_scores_codex":[0.9998938,0.000028201679,0.0000035783155,0.0000124970065,0.000029711331,0.000032274234],"domain_scores_gemma":[0.99976677,0.0001551468,0.000018120161,0.00000917129,0.000031725598,0.00001905562],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003294877,0.000551185,0.001219691,0.0005752142,0.0005720685,0.0007837815,0.0009407327,0.00087260455,0.0032827677],"category_scores_gemma":[0.0006711624,0.00028246545,0.00067879114,0.00038156117,0.0004342323,0.00031920208,0.00039494835,0.0005421268,0.0001924329],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014542174,0.0000896261,0.0009269859,0.00008225165,0.00005086594,0.00018644532,0.000016744718,0.98667645,0.0014729655,0.00579948,0.0005550774,0.0039976607],"study_design_scores_gemma":[0.000037900514,0.000042283296,0.00012931965,0.0000027480214,0.00001516108,0.000012157816,0.000010099457,0.99851435,0.00026154073,0.0007829303,0.00018878683,0.000002772291],"about_ca_topic_score_codex":0.017378123,"about_ca_topic_score_gemma":0.013992491,"teacher_disagreement_score":0.017378123,"about_ca_system_score_codex":0.0010307541,"about_ca_system_score_gemma":0.0015399342,"threshold_uncertainty_score":0.034553945},"labels":[],"label_agreement":null},{"id":"W84114842","doi":"10.1016/s0960-894x(01)00209-8","title":"Powerful probes for glycosidases","year":2001,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Networks of Centres of Excellence of Canada","keywords":"Chemistry; Dansyl chloride; Amide; Stereochemistry; Fluorescence; Dipeptide; Chemical synthesis; Derivatization; Biochemistry; Amino acid; Chromatography; In vitro; Mass spectrometry","score_opus":0.01607263138666733,"score_gpt":0.2346794287452205,"score_spread":0.21860679735855315,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W84114842","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.63172907,0.041523136,0.22717585,0.0051940326,0.0017921284,0.00038248757,0.0025895885,0.003041116,0.0865726],"genre_scores_gemma":[0.91040945,0.012793417,0.04613778,0.0015121808,0.0003335558,0.0003425314,0.0014938586,0.00022027083,0.026757015],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99974245,0.00005739898,0.000007850026,0.00005903184,0.00006524073,0.00006801933],"domain_scores_gemma":[0.9998247,0.000067294575,0.000020769672,0.00003403659,0.000015916097,0.000037235324],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00060954975,0.00087232515,0.0002973078,0.00054889213,0.0003271517,0.0006137102,0.00068862544,0.0009024019,0.0049448595],"category_scores_gemma":[0.00048757353,0.00038358095,0.00032028148,0.0002479654,0.0005952167,0.00086271256,0.0010723084,0.002180738,0.0015042789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002624316,0.000053374515,0.00014536578,0.00014691893,0.000017380946,0.00015180006,0.00008099015,0.00023409857,0.9676499,0.0139768515,0.0025122943,0.014768566],"study_design_scores_gemma":[0.0000530207,0.00023160082,0.0002788422,0.0000149741145,0.000015704205,0.00029619905,0.00002514774,0.00064579013,0.9681511,0.0016410479,0.02863265,0.00001401332],"about_ca_topic_score_codex":0.00012120186,"about_ca_topic_score_gemma":0.00030278397,"teacher_disagreement_score":0.0049448595,"about_ca_system_score_codex":0.0005764414,"about_ca_system_score_gemma":0.00015522091,"threshold_uncertainty_score":0.016542196},"labels":[],"label_agreement":null},{"id":"W849491502","doi":"10.1016/j.bmcl.2015.06.059","title":"3-Hydroxy-4-pyridinone derivatives designed for fluorescence studies to determine interaction with amyloid protein as well as cell permeability","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Generalitat de Catalunya; Natural Sciences and Engineering Research Council of Canada; Alzheimer Society","keywords":"Chemistry; Fluorescence; Amyloid (mycology); Cell permeability; Combinatorial chemistry; Amyloid beta; Amyloid fibril; Stereochemistry; Fibril; Chemical synthesis; In vitro; Amyloid β; Biophysics; Biochemistry; Peptide; Disease","score_opus":0.050886242496415914,"score_gpt":0.32540908438887123,"score_spread":0.2745228418924553,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W849491502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98832256,0.0007928222,0.007814838,0.00008646978,0.00004899171,0.000104871484,0.0002928886,0.00010535989,0.0024312043],"genre_scores_gemma":[0.98584545,0.000549277,0.010085245,0.00009328838,0.0000082425495,0.00010623887,0.00042065216,0.000025080155,0.0028666458],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9998313,0.000039339782,0.000011591536,0.000031375028,0.000037011432,0.000049315055],"domain_scores_gemma":[0.9998061,0.00004084128,0.00005400347,0.000027188364,0.00003142107,0.000040452407],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030288994,0.0003652991,0.0002642323,0.00014389085,0.00019295451,0.00020345005,0.00040058093,0.00042413475,0.0015230828],"category_scores_gemma":[0.00023917868,0.0001906295,0.0001974006,0.00017389281,0.00029503644,0.00027334303,0.00014699633,0.0006280338,0.00036472167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003464089,0.000057525853,0.0001423659,0.00005625707,0.0000057923835,0.00013831355,0.00003410739,0.00046512496,0.996414,0.0002882386,0.000059176593,0.0019927688],"study_design_scores_gemma":[0.00006631485,0.000701985,0.00081738626,0.000003949829,0.000012815082,0.00015986872,0.0000114694785,0.00059709704,0.9955155,0.00006185966,0.0020401077,0.000011634641],"about_ca_topic_score_codex":0.00058583805,"about_ca_topic_score_gemma":0.00072787557,"teacher_disagreement_score":0.0015230828,"about_ca_system_score_codex":0.00038001058,"about_ca_system_score_gemma":0.0002846338,"threshold_uncertainty_score":0.005095184},"labels":[],"label_agreement":null},{"id":"W932643426","doi":"10.1016/j.bmcl.2015.07.021","title":"Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"hERG; Calcitonin gene-related peptide; Chemistry; Pharmacology; Pharmacokinetics; Calcitonin; Potency; IC50; Migraine; Receptor; Chemical synthesis; In vitro; Internal medicine; Neuropeptide; Biochemistry; Medicine; Potassium channel","score_opus":0.045436472715802236,"score_gpt":0.2969502360386794,"score_spread":0.25151376332287717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W932643426","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86150706,0.121857606,0.0026292538,0.0016285654,0.0005976697,0.00034717633,0.0003837856,0.00012713597,0.010921805],"genre_scores_gemma":[0.92993706,0.059672054,0.0027558126,0.00085423054,0.0002709513,0.0001656063,0.00040589512,0.000012453885,0.0059258803],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9999256,0.000024668967,0.000008011217,0.000007747547,0.000011426799,0.00002251108],"domain_scores_gemma":[0.9999461,0.000014452373,0.000012687995,0.0000025397756,0.000006992097,0.000017179746],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030471265,0.00022908213,0.00051009527,0.00020584208,0.00021542441,0.00029266856,0.00035372833,0.00023916115,0.0029882253],"category_scores_gemma":[0.00024808742,0.00008548106,0.00021929167,0.00020766121,0.00023290259,0.00022350436,0.00014909856,0.00070756645,0.00032677673],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.026267244,0.0037829573,0.0033022629,0.0029493016,0.00036163576,0.0026880102,0.0006201245,0.00082690007,0.34375176,0.003917456,0.007231253,0.6043011],"study_design_scores_gemma":[0.12477352,0.21077901,0.11350185,0.001360646,0.0027636758,0.020100785,0.0010336813,0.006054438,0.20564006,0.0035274168,0.31010264,0.00036237086],"about_ca_topic_score_codex":0.0006187833,"about_ca_topic_score_gemma":0.002997773,"teacher_disagreement_score":0.0029882253,"about_ca_system_score_codex":0.00020157399,"about_ca_system_score_gemma":0.0002735513,"threshold_uncertainty_score":0.009996593},"labels":[],"label_agreement":null},{"id":"W937127559","doi":"10.1016/j.bmcl.2015.07.093","title":"Recent progress on MAP kinase pathway inhibitors","year":2015,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"MAPK/ERK pathway; Signal transduction; Kinase; Anti-apoptotic Ras signalling cascade; Chemistry; Mitogen-activated protein kinase; Intracellular; Cancer research; Cell biology; Computational biology; Biology; Biochemistry","score_opus":0.03257826275852975,"score_gpt":0.2847047729781015,"score_spread":0.2521265102195717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W937127559","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0006399501,0.99530184,0.00064917817,0.0003582235,0.00036284697,0.000012466372,0.00004569574,0.000025318557,0.0026044506],"genre_scores_gemma":[0.003810271,0.9927301,0.00051180436,0.0005275615,0.0002658183,0.000021463802,0.00008304019,0.0000046203772,0.0020453774],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99986434,0.000019972162,0.000016840268,0.000027587328,0.00004421495,0.000027010019],"domain_scores_gemma":[0.99985385,0.00006440413,0.00002707821,0.0000057650473,0.000030164341,0.000018786477],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00047037893,0.00093040965,0.0011404662,0.0012620853,0.00021431687,0.0007924187,0.00071874826,0.0006243022,0.0033655502],"category_scores_gemma":[0.0005438161,0.000356994,0.00042344455,0.0013755615,0.00037738116,0.0010909479,0.0006718625,0.0018187023,0.0014531929],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002337875,0.00014996613,0.00018106458,0.010396806,0.0001079972,0.0002748099,0.000049407812,0.00072166586,0.0068618795,0.0038647703,0.029410655,0.9477472],"study_design_scores_gemma":[0.00009583719,0.00027176604,0.00058441446,0.0009716884,0.0002416501,0.0007925313,0.000032858534,0.000329422,0.0035931186,0.0020281847,0.9910343,0.00002420813],"about_ca_topic_score_codex":0.00047905423,"about_ca_topic_score_gemma":0.0013467214,"teacher_disagreement_score":0.0033655502,"about_ca_system_score_codex":0.00047547912,"about_ca_system_score_gemma":0.0006917327,"threshold_uncertainty_score":0.0112589},"labels":[],"label_agreement":null},{"id":"W971493459","doi":"10.1016/j.bmcl.2015.07.072","title":"The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential","year":2015,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Prokaryote; Signal peptidase; Biology; Biochemistry; Antibacterial agent; Function (biology); Chemistry; Signal peptide; Antibiotics; Cell biology; Peptide sequence; Gene","score_opus":0.029655227285496178,"score_gpt":0.2721371999005039,"score_spread":0.2424819726150077,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W971493459","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"metacan-v3-hybrid-931329e0061c","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0004713818,0.99735934,0.00037853353,0.0002682054,0.0003219751,0.0000043330824,0.000028677629,0.000011233031,0.0011563496],"genre_scores_gemma":[0.0031852173,0.99471396,0.00032462296,0.00029019616,0.00020037433,0.000008429342,0.000052709376,0.0000020900532,0.0012224306],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99991155,0.000009645881,0.000010420895,0.000015219131,0.000036682286,0.000016556043],"domain_scores_gemma":[0.9999068,0.000034728037,0.000021309492,0.0000035246455,0.000021033928,0.000012599006],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031086616,0.0007426398,0.0008513493,0.0006762994,0.0001069673,0.0005693031,0.0005627909,0.0007564757,0.0015416369],"category_scores_gemma":[0.0003083654,0.00018275323,0.0002604582,0.0007830521,0.00034216212,0.00065724074,0.00041211298,0.001311029,0.0011728386],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024209463,0.000078074496,0.00015594445,0.01049756,0.00009749033,0.00042988258,0.000029519952,0.00044046997,0.018637685,0.0050236257,0.027232245,0.9371354],"study_design_scores_gemma":[0.000049910745,0.00020031468,0.0006248088,0.0008943471,0.00012676932,0.0015995463,0.000028324714,0.00013128754,0.0060925693,0.0017502636,0.9884809,0.0000209848],"about_ca_topic_score_codex":0.00030944005,"about_ca_topic_score_gemma":0.0006764141,"teacher_disagreement_score":0.0015416369,"about_ca_system_score_codex":0.0003426709,"about_ca_system_score_gemma":0.00044008179,"threshold_uncertainty_score":0.005157292},"labels":[],"label_agreement":null}]}