{"meta":{"query_hash":"1e0076a3c87b","filters":{"venue":"European Journal of Medicinal Chemistry"},"cohort_total":268,"direct_labels_cover":0,"predictions_cover":268,"exported":268,"export_cap":100000,"truncated":false,"label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"permalink":"https://metacan.xera.ac/q/1e0076a3c87b","api":"https://metacan.xera.ac/api/v1/cohort?venue=European+Journal+of+Medicinal+Chemistry"},"results":[{"id":"W1470644747","doi":"10.1016/j.ejmech.2015.09.017","title":"Optimization of on-resin palladium-catalyzed Sonogashira cross-coupling reaction for peptides and its use in a structure–activity relationship study of a class B GPCR ligand","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Sonogashira coupling; Chemistry; G protein-coupled receptor; Ligand (biochemistry); Combinatorial chemistry; Peptide; Peptide synthesis; Stereochemistry; Alkyne; Receptor; Peptidomimetic; Chemical synthesis; Palladium; Catalysis; Biochemistry; In vitro","score_opus":0.10786873780149381,"score_gpt":0.31792196430082936,"score_spread":0.21005322649933555,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1470644747","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9995548,0.000023915023,0.000045179004,0.000028523353,0.00007268496,0.00014687264,0.000010347657,0.0000052852038,0.000112406145],"genre_scores_gemma":[0.9996716,0.000013914269,0.00010023177,0.000018750574,0.00014639307,6.213336e-7,0.0000012597457,0.000021530574,0.000025711857],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99866897,0.0001291246,0.0005514682,0.000223518,0.0002918789,0.00013505698],"domain_scores_gemma":[0.9982504,0.00047180027,0.0008011646,0.0001264706,0.00023302362,0.000117102856],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006585322,0.00013481577,0.00030436378,0.00008740591,0.00004946456,0.000024319204,0.00016233305,0.000033832766,0.0000020318118],"category_scores_gemma":[0.0034457694,0.000111957655,0.000046599875,0.00015899439,0.000100017,0.00026476645,0.000042487405,0.00033835892,2.622607e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018901915,0.00020962617,0.0044701756,0.00007804639,0.0000078077355,0.000055878758,0.00040050526,0.026083928,0.9667064,0.000008590077,0.0000130934795,0.00007576325],"study_design_scores_gemma":[0.0062438636,0.0023542815,0.09057348,0.00038451378,0.000060019975,0.00015992403,0.00062096084,0.0049242866,0.8944347,0.000048271377,0.00002853955,0.00016715442],"about_ca_topic_score_codex":0.000005173858,"about_ca_topic_score_gemma":0.0000018796264,"teacher_disagreement_score":0.086103305,"about_ca_system_score_codex":0.000034774974,"about_ca_system_score_gemma":0.000062044004,"threshold_uncertainty_score":0.45655006},"labels":[],"label_agreement":null},{"id":"W1524487285","doi":"10.1016/s0223-5234(00)01209-5","title":"5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides","year":2001,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Aryl; In vivo; Stereochemistry; Benzene derivatives; Lead compound; Chemical synthesis; Benzene; Bicyclic molecule; Antagonist; Penetration (warfare); Receptor; Pharmacology; Combinatorial chemistry; In vitro; Biochemistry; Organic chemistry","score_opus":0.08265660956436664,"score_gpt":0.30872871759522497,"score_spread":0.2260721080308583,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1524487285","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9977835,0.0005596154,0.00008186049,0.0005085887,0.0001621351,0.00012221007,0.000007663253,0.000015712309,0.0007587591],"genre_scores_gemma":[0.9979426,0.0011938467,0.00037152405,0.00018516467,0.00024248444,0.0000014737175,0.000002552524,0.000022163831,0.00003815867],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9976217,0.00030554744,0.0007081548,0.00031852094,0.0008360457,0.00021003156],"domain_scores_gemma":[0.99870074,0.00015361753,0.0005644181,0.00017167113,0.00021370295,0.00019585488],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018741622,0.00020275556,0.0003051988,0.00007328382,0.00007995291,0.00003597939,0.00027824653,0.00005075395,0.00027317743],"category_scores_gemma":[0.0008229007,0.00016149168,0.0000664869,0.00014773554,0.00049630913,0.0002332578,0.000054609805,0.00037995778,0.0000057833818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018585475,0.00007377118,0.0066878917,0.00003899277,0.0000057347925,0.00013485186,0.00022606095,0.000012938473,0.9619575,0.000002037153,0.00008131756,0.030593026],"study_design_scores_gemma":[0.002074525,0.00055822183,0.026309725,0.00025786666,0.000092325114,0.0027070348,0.00022816872,0.000118816664,0.9666982,0.00002769285,0.0007458052,0.00018160127],"about_ca_topic_score_codex":0.000001459347,"about_ca_topic_score_gemma":8.057627e-8,"teacher_disagreement_score":0.030411424,"about_ca_system_score_codex":0.000051761734,"about_ca_system_score_gemma":0.00005605639,"threshold_uncertainty_score":0.65854394},"labels":[],"label_agreement":null},{"id":"W1634130474","doi":"10.1016/j.ejmech.2015.09.012","title":"Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Fonds de Recherche du Québec - Société et culture; Hôtel-Dieu de Québec; Hôpital Saint-François d'Assise; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cell cycle; Cell cycle checkpoint; DNA; Ring (chemistry); DNA damage; Alkoxy group; Nitro; Stereochemistry; DNA synthesis; Alkyl; Cell; Biochemistry","score_opus":0.0779131060161098,"score_gpt":0.30222419609778955,"score_spread":0.22431109008167976,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1634130474","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9950256,0.001108167,0.0025195421,0.00013024322,0.00016822126,0.00005198735,0.0000066503635,0.000001029439,0.0009886135],"genre_scores_gemma":[0.9991153,0.00023778874,0.00023748579,0.000052698695,0.00032225277,7.6401454e-7,0.000002891008,0.000010111727,0.000020741547],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989163,0.00014009998,0.0003330623,0.00011422282,0.00041127013,0.000084994754],"domain_scores_gemma":[0.9989165,0.00001203032,0.00045701902,0.0001344269,0.000406451,0.00007355833],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015462864,0.00008984745,0.00015244434,0.000013924036,0.000025226043,0.000004922572,0.00016018905,0.000038857215,0.000022509132],"category_scores_gemma":[0.00040313439,0.000060537248,0.00007086217,0.000047593032,0.00012062859,0.0000046719133,0.000071187045,0.00008686324,1.16392826e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017938402,0.000047297985,0.00023281135,0.000020172087,0.00007952009,0.0000020633179,0.000089246416,0.00064291706,0.9902167,0.0000118388625,0.00003578892,0.008442272],"study_design_scores_gemma":[0.0014571822,0.00022015128,0.006372225,0.00015337071,0.0001435523,0.00011416308,0.00033196685,0.0007426372,0.98930246,0.00009805731,0.0009895565,0.00007467772],"about_ca_topic_score_codex":0.0000022362199,"about_ca_topic_score_gemma":1.9201576e-7,"teacher_disagreement_score":0.008367595,"about_ca_system_score_codex":0.000016804035,"about_ca_system_score_gemma":0.00013219407,"threshold_uncertainty_score":0.24686374},"labels":[],"label_agreement":null},{"id":"W1963965930","doi":"10.1016/j.ejmech.2013.11.012","title":"Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lakehead University","funders":"Chinese Academy of Sciences","keywords":"Biotinylation; Biotin; Chemistry; Cytotoxicity; In vitro; Receptor; Cell culture; Biochemistry; Cell growth; Biology","score_opus":0.006040501039467891,"score_gpt":0.1865495686437069,"score_spread":0.18050906760423902,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1963965930","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99142766,0.0020013037,0.000080111306,0.0004593764,0.00010313583,0.00005676779,0.000014842675,0.0000051138827,0.005851665],"genre_scores_gemma":[0.9980122,0.0004283078,0.00037183682,0.00014093962,0.0007905718,0.0000010280219,0.0000062592817,0.000025450961,0.00022343532],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99880385,0.00010893556,0.00039784095,0.00018841034,0.0003119385,0.00018902458],"domain_scores_gemma":[0.9987449,0.00005239312,0.0004502955,0.00014638902,0.00032534005,0.000280693],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044665922,0.00018242087,0.0002764142,0.000043182445,0.00004394752,0.000009427498,0.000230487,0.000052080562,0.00009695522],"category_scores_gemma":[0.00027479033,0.00014652667,0.00011721902,0.00006858509,0.00028492804,0.000013120155,0.000071307455,0.00026502623,0.000006305309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019336813,0.0001269274,0.00069385546,0.00017771011,0.00006349386,0.00014136896,0.00003766581,0.0000022974143,0.99023587,9.63346e-7,0.0060976576,0.002228815],"study_design_scores_gemma":[0.0008509151,0.00060854695,0.012308917,0.00020529443,0.00007314775,0.001093545,0.00019038473,0.000003768864,0.9810197,0.000009218407,0.0034879618,0.0001486344],"about_ca_topic_score_codex":0.000006852341,"about_ca_topic_score_gemma":1.2313492e-7,"teacher_disagreement_score":0.011615062,"about_ca_system_score_codex":0.000012788739,"about_ca_system_score_gemma":0.00010327485,"threshold_uncertainty_score":0.5975184},"labels":[],"label_agreement":null},{"id":"W1964649330","doi":"10.1016/j.ejmech.2014.03.056","title":"Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Douglas Mental Health University Institute; McGill University","funders":"Agence Nationale de la Recherche","keywords":"Chemistry; Glutamatergic; Glutamate receptor; Pharmacology; Neurotransmission; Neurotransmitter; Synaptic vesicle; Monoamine neurotransmitter; Metabotropic glutamate receptor; Biochemistry; Receptor; Biology; Vesicle","score_opus":0.09480028738229125,"score_gpt":0.31390020695440596,"score_spread":0.21909991957211472,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1964649330","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9976451,0.00015141907,0.0005583335,0.0005931882,0.00016882339,0.00010892235,0.0000013801397,0.000010954536,0.0007619198],"genre_scores_gemma":[0.99902415,0.00034665116,0.00007036536,0.0003276521,0.00019689892,0.0000017187169,1.1756618e-7,0.000016356733,0.000016084266],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.996165,0.0017562263,0.0005576024,0.00030854106,0.0009486282,0.00026404738],"domain_scores_gemma":[0.9984113,0.0005988371,0.00040955035,0.00014663256,0.00017081457,0.0002628559],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005460952,0.00016105654,0.0002915145,0.00008752198,0.00010378733,0.00002020938,0.00044035865,0.000037474634,0.000077654164],"category_scores_gemma":[0.003177857,0.00011543154,0.0000890819,0.000189806,0.0006306708,0.00008912354,0.000050119208,0.000409022,0.0000067759115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022073135,0.00007440023,0.00019929807,0.00003811002,0.000007233674,0.0004945482,0.00010568438,0.00012625875,0.98476607,0.000001519997,0.000043556698,0.013922572],"study_design_scores_gemma":[0.00090024335,0.00063149224,0.0019987037,0.00013116028,0.00009976368,0.0010901479,0.000070467715,0.00062671845,0.9941669,0.000041204792,0.00014376648,0.00009942538],"about_ca_topic_score_codex":5.2096584e-7,"about_ca_topic_score_gemma":1.16854855e-8,"teacher_disagreement_score":0.013823147,"about_ca_system_score_codex":0.00002248577,"about_ca_system_score_gemma":0.00010797591,"threshold_uncertainty_score":0.47071615},"labels":[],"label_agreement":null},{"id":"W1965771968","doi":"10.1016/j.ejmech.2014.03.009","title":"Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: Structure–activity relationships and potent antileukemic and antilymphoma cytotoxicity","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Chemistry; Cytotoxicity; Cytotoxic T cell; HeLa; Stereochemistry; Apoptosis; Structure–activity relationship; L1210 cells; Cell culture; Leukemia; In vitro; IC50; Cancer research; Pharmacology; Biochemistry; Immunology; Biology","score_opus":0.020687049170030947,"score_gpt":0.20936521963869992,"score_spread":0.18867817046866897,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1965771968","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9909314,0.0006494361,0.00063669635,0.00030452278,0.00007439072,0.00002848705,0.000022094166,0.000026920678,0.007326075],"genre_scores_gemma":[0.99815774,0.0001728921,0.0006006417,0.000075414515,0.0008427473,3.3861213e-7,0.0000030880049,0.00002767949,0.000119488264],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99823433,0.00018384114,0.0005187964,0.00036207796,0.00041152842,0.0002894372],"domain_scores_gemma":[0.9981363,0.0004851018,0.00063391664,0.00025027498,0.00010922012,0.00038519327],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013591055,0.00030701794,0.0005134922,0.00003701811,0.00021425265,0.00006090281,0.0002828345,0.00013547573,0.0002582709],"category_scores_gemma":[0.0013508925,0.00022173529,0.00011756228,0.000079647005,0.00035613475,0.00016592885,0.0001390397,0.0008854174,0.0000019344568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021128458,0.00009325364,0.010235091,0.00014351873,0.000062808154,0.00007715778,0.00006660027,0.0000037873504,0.9716081,0.0000050004824,0.00011978164,0.017373586],"study_design_scores_gemma":[0.0021761532,0.00016087903,0.18758267,0.00047935263,0.00015853105,0.0037611003,0.00028377297,0.00033904496,0.8024181,0.00005520719,0.002178036,0.0004071312],"about_ca_topic_score_codex":0.000007916788,"about_ca_topic_score_gemma":6.777318e-7,"teacher_disagreement_score":0.17734759,"about_ca_system_score_codex":0.00008006127,"about_ca_system_score_gemma":0.000058311445,"threshold_uncertainty_score":0.90421027},"labels":[],"label_agreement":null},{"id":"W1966213796","doi":"10.1016/j.ejmech.2011.10.015","title":"An effort to discover the preferred conformation of the potent AMG3 cannabinoid analog when reaching the active sites of the cannabinoid receptors","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Pharmacophore; Quantitative structure–activity relationship; Conformational isomerism; Cannabinoid receptor; Cannabinoid; Affinities; Stereochemistry; Molecular model; Docking (animal); Receptor; Molecule; Biochemistry; Organic chemistry","score_opus":0.028347386995673615,"score_gpt":0.25790131846206116,"score_spread":0.22955393146638753,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966213796","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9707913,0.000107845284,0.017669208,0.003848425,0.00054360245,0.00021986205,0.000010053436,0.000008107256,0.006801637],"genre_scores_gemma":[0.9978026,0.0000064816427,0.0014017966,0.0004319631,0.00020722457,0.0000015929455,0.0000015457092,0.000011504274,0.00013530407],"study_design_codex":"qualitative","study_design_gemma":"observational","domain_scores_codex":[0.99700195,0.0008792535,0.00072208536,0.00016805796,0.0010313198,0.00019731271],"domain_scores_gemma":[0.99745184,0.00014578979,0.0011358424,0.0007514905,0.00039672354,0.00011828929],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003265125,0.00017632413,0.00022912695,0.000039446193,0.00020835342,0.000036724683,0.0029229142,0.000026641763,0.000019455929],"category_scores_gemma":[0.00051450095,0.00007397935,0.00019871705,0.00032054842,0.00028311356,0.00040850585,0.0004336823,0.00060701056,0.0000010314125],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018466202,0.0010097919,0.022704603,0.0005721957,0.0012008506,0.00008351307,0.39811435,0.07583819,0.28991592,0.0037552265,0.035878178,0.16908056],"study_design_scores_gemma":[0.001167592,0.0005912064,0.5513892,0.00077441556,0.00023910057,0.0005669566,0.0071551027,0.0063616303,0.42506245,0.0019995233,0.004312916,0.00037986107],"about_ca_topic_score_codex":0.00010345425,"about_ca_topic_score_gemma":0.000010740961,"teacher_disagreement_score":0.5286846,"about_ca_system_score_codex":0.00010279452,"about_ca_system_score_gemma":0.00035869083,"threshold_uncertainty_score":0.543155},"labels":[],"label_agreement":null},{"id":"W1966336396","doi":"10.1016/j.ejmech.2011.03.020","title":"Microwave assisted synthesis and structure–activity relationship of 4-hydroxy-N′-[1-phenylethylidene]-2H/2-methyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides as anti-microbial agents","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Benzothiazine; Carbohydrazide; Microwave; Stereochemistry; Structure–activity relationship; Bicyclic molecule; Chemical synthesis; Combinatorial chemistry; Medicinal chemistry; In vitro; Biochemistry","score_opus":0.025774195627918176,"score_gpt":0.23651215297632372,"score_spread":0.21073795734840556,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966336396","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9913684,0.0013796724,0.00034714275,0.00009538612,0.00021431649,0.000076568846,0.0000397852,0.000009426256,0.006469262],"genre_scores_gemma":[0.9975915,0.00025017097,0.0011703592,0.00010367356,0.00061284855,0.0000010736549,0.0000095428295,0.000062175764,0.00019868807],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9977637,0.00035750846,0.00080093514,0.0003748778,0.00037801702,0.00032497966],"domain_scores_gemma":[0.99791974,0.00014229544,0.0010271762,0.00039008335,0.000266397,0.00025432135],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00095211965,0.00037813594,0.0006039509,0.00010090765,0.00013093532,0.00003055726,0.0004426773,0.00016574204,0.00018363225],"category_scores_gemma":[0.0010986049,0.0003173459,0.00027185673,0.00014146016,0.00039204865,0.00003231525,0.00016219336,0.0004363394,0.0000029626476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037714472,0.00015371153,0.0040872507,0.00019567835,0.00024421042,0.00012590944,0.00035480302,0.0000072237067,0.9899915,0.000008651955,0.0004758944,0.0039780564],"study_design_scores_gemma":[0.0007750721,0.00026156838,0.05395458,0.0003368955,0.0002414615,0.00085582514,0.0003798932,0.0000074479854,0.9417343,0.00007499608,0.0010715275,0.00030641438],"about_ca_topic_score_codex":0.000029731455,"about_ca_topic_score_gemma":0.0000044115645,"teacher_disagreement_score":0.04986733,"about_ca_system_score_codex":0.000025519215,"about_ca_system_score_gemma":0.00014487877,"threshold_uncertainty_score":0.9999279},"labels":[],"label_agreement":null},{"id":"W1966351884","doi":"10.1016/j.ejmech.2012.02.042","title":"Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"National Cancer Institute; Canadian Institutes of Health Research; Institute of Materials Research and Engineering; Saskatchewan Health Research Foundation","keywords":"Chemistry; Multiple drug resistance; Cytotoxicity; Cytotoxic T cell; Apoptosis; Flow cytometry; DNA fragmentation; In vitro; Stereochemistry; Cell cycle; Cancer cell; Topoisomerase; Molecular biology; Cancer; Programmed cell death; Biochemistry; Biology; Genetics","score_opus":0.02186838367758064,"score_gpt":0.24694791080712952,"score_spread":0.22507952712954887,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1966351884","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.984228,0.0057296627,0.0075624865,0.00012099483,0.00039463653,0.0000895813,0.000009571894,0.0000061324827,0.0018589229],"genre_scores_gemma":[0.99637085,0.00021507141,0.0013006243,0.00023411102,0.001465273,0.0000018751257,0.00000716444,0.000055951,0.0003490839],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99835,0.00010587953,0.000621131,0.00018978512,0.00038235894,0.00035079563],"domain_scores_gemma":[0.9985529,0.0000181894,0.0006323695,0.00023514272,0.00031653955,0.00024482133],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00089961087,0.00023879213,0.0003374885,0.000045251152,0.00007531225,0.000019024706,0.00032849686,0.00006325883,0.000025081192],"category_scores_gemma":[0.00017250895,0.00018726403,0.00019673727,0.000105700645,0.00016471682,0.000017395785,0.00010705716,0.00028864425,0.0000015951389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00073200336,0.00020253932,0.00010342512,0.000119453325,0.00016177568,0.00001717168,0.0005431155,0.00005396333,0.99677914,0.0000030427484,0.00019558039,0.001088812],"study_design_scores_gemma":[0.0017011706,0.0004917414,0.00081451953,0.0003305503,0.00012594688,0.00045524337,0.0010096834,0.000031034542,0.98614764,0.000001970115,0.00867133,0.00021918314],"about_ca_topic_score_codex":0.000006858107,"about_ca_topic_score_gemma":6.8591413e-7,"teacher_disagreement_score":0.012142835,"about_ca_system_score_codex":0.000050851344,"about_ca_system_score_gemma":0.00021223213,"threshold_uncertainty_score":0.7636405},"labels":[],"label_agreement":null},{"id":"W1967412933","doi":"10.1016/j.ejmech.2011.12.022","title":"Structure–activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Carbonic Anhydrase I; Carbonic anhydrase; Stereochemistry; Indole test; Isozyme; Gene isoform; Enzyme; Carbonic anhydrase II; Docking (animal); Structure–activity relationship; Active site; Biochemistry; In vitro","score_opus":0.02415928855435353,"score_gpt":0.2364411026035657,"score_spread":0.21228181404921218,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1967412933","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9956919,0.00049033656,0.0016800383,0.00009956808,0.00004157004,0.00007227845,0.0000060942607,0.0000027364795,0.0019154747],"genre_scores_gemma":[0.99905545,0.000057349833,0.00018352999,0.000037276382,0.00027331113,9.2493036e-7,0.000012177933,0.000013621442,0.00036635002],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99935645,0.00005992898,0.0002457151,0.00012745439,0.00011839682,0.00009206281],"domain_scores_gemma":[0.9992449,0.000031413998,0.0003909722,0.00011592146,0.00013981415,0.00007692105],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00047371254,0.00011252127,0.0001330807,0.000026129112,0.00016976986,0.000008275366,0.00007667121,0.000044138316,0.0000732641],"category_scores_gemma":[0.00014143583,0.00007081779,0.000039899514,0.00004174776,0.00019129255,0.000018497443,0.00003996035,0.00024767956,6.1182206e-8],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012399006,0.00004400594,0.0011394551,0.000041639556,0.00008267756,0.0000051514708,0.00044102262,0.000008730419,0.99560297,0.0000052904265,0.0006617908,0.00072735717],"study_design_scores_gemma":[0.002234417,0.0021772813,0.010345102,0.00015211981,0.00010889477,0.00050782814,0.0010961535,0.00007235961,0.9817368,0.00003912779,0.0014108457,0.00011911714],"about_ca_topic_score_codex":0.0000039415827,"about_ca_topic_score_gemma":0.000005389768,"teacher_disagreement_score":0.013866225,"about_ca_system_score_codex":0.00001058216,"about_ca_system_score_gemma":0.000032462573,"threshold_uncertainty_score":0.28878656},"labels":[],"label_agreement":null},{"id":"W1968763546","doi":"10.1016/j.ejmech.2009.02.028","title":"Synthesis and evaluation of anti-tumor activities of N4 fatty acyl amino acid derivatives of 1-β-arabinofuranosylcytosine","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Lipophilicity; Chemistry; Bioavailability; In vivo; Cytarabine; Cytotoxicity; Chemical synthesis; In vitro; HeLa; Stereochemistry; Fatty acid; Biochemistry; Pharmacology; Leukemia","score_opus":0.023593606934095485,"score_gpt":0.25178578909832844,"score_spread":0.22819218216423295,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1968763546","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9829898,0.0016608888,0.000043557382,0.0001447627,0.00003040256,0.00003377636,0.000035826484,0.000008152785,0.015052847],"genre_scores_gemma":[0.9991974,0.00022374053,0.00024428393,0.000012706067,0.00025488262,7.7063646e-7,0.0000045409747,0.000022565413,0.0000390757],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9972566,0.00015725275,0.0011680253,0.00021516363,0.0010025369,0.00020042597],"domain_scores_gemma":[0.99685174,0.00033922118,0.0017745041,0.00033412938,0.0005481572,0.00015221762],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016739236,0.00026964484,0.0008122327,0.00006801825,0.000041981915,0.000010119132,0.0003805809,0.000069365655,0.00060771423],"category_scores_gemma":[0.0015881164,0.00023337605,0.00021567763,0.00015280646,0.00046087842,0.00015111403,0.00004783984,0.00032526764,2.972902e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031170255,0.00020799183,0.0010188594,0.0009590173,0.00016133067,0.000057074238,0.00058102095,0.000020820162,0.9840394,0.0000014902167,0.000052873616,0.012588416],"study_design_scores_gemma":[0.0011383762,0.00009721385,0.0068910103,0.0016397593,0.0005120959,0.00033531,0.0022099046,0.00006312063,0.9868773,0.000029108895,0.000034761233,0.00017202485],"about_ca_topic_score_codex":0.0000017049011,"about_ca_topic_score_gemma":6.8828115e-8,"teacher_disagreement_score":0.016207648,"about_ca_system_score_codex":0.000053920532,"about_ca_system_score_gemma":0.00016165222,"threshold_uncertainty_score":0.9516799},"labels":[],"label_agreement":null},{"id":"W1970604092","doi":"10.1016/j.ejmech.2005.02.005","title":"Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates","year":2005,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Pyrrole; Imidazole; Polyamide; Stereochemistry; Combinatorial chemistry; In vitro; Conjugate; Organic chemistry; Biochemistry","score_opus":0.04219036408863442,"score_gpt":0.28745544237253745,"score_spread":0.24526507828390304,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1970604092","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9798195,0.016807217,0.000088322995,0.0013717313,0.000039246697,0.00004676758,0.000022120876,0.000014152271,0.0017909501],"genre_scores_gemma":[0.99391925,0.002423141,0.0028867878,0.00017196593,0.0004797146,0.0000035105033,0.0000015501844,0.000039309703,0.00007477318],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9979128,0.00014408014,0.0010175047,0.00028013217,0.00032396222,0.00032152352],"domain_scores_gemma":[0.99737406,0.0012846458,0.0007736372,0.00017350765,0.00016380896,0.00023034174],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00159263,0.00031855295,0.0008066185,0.00012359735,0.00007415567,0.000016638685,0.00031348554,0.00007758091,0.00024352787],"category_scores_gemma":[0.0013001297,0.00026941608,0.000094466406,0.000112981026,0.00062649325,0.00016065332,0.00011679944,0.00049788144,0.0000013771333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007299936,0.00019057619,0.0005526937,0.0003995975,0.00025754957,0.00015043399,0.00087674346,0.000089588524,0.989567,5.719355e-7,0.00029556942,0.0068896846],"study_design_scores_gemma":[0.0019538638,0.00006683889,0.0013488575,0.0008459521,0.00016474373,0.0005381201,0.0019654173,0.0002776043,0.9917685,0.00000501497,0.0008370249,0.00022810255],"about_ca_topic_score_codex":0.0000022403208,"about_ca_topic_score_gemma":4.024051e-7,"teacher_disagreement_score":0.014384077,"about_ca_system_score_codex":0.00005185425,"about_ca_system_score_gemma":0.00007943158,"threshold_uncertainty_score":0.9999758},"labels":[],"label_agreement":null},{"id":"W1973737572","doi":"10.1016/j.ejmech.2011.05.074","title":"Synthesis and structure–activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":86,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Mount Allison University; National Research Council Canada; Université de Moncton","funders":"","keywords":"Chemistry; Aromatase; Letrozole; Triazole; Structure–activity relationship; Stereochemistry; Pharmacology; Carboxamide; 1,2,3-Triazole; Combinatorial chemistry; In vitro; Biochemistry; Internal medicine; Organic chemistry","score_opus":0.03170932395664469,"score_gpt":0.24112894982060473,"score_spread":0.20941962586396004,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1973737572","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9892699,0.00053417386,0.00009183144,0.00015761761,0.000022755705,0.000024649105,0.00007833099,0.000017909413,0.009802793],"genre_scores_gemma":[0.99906915,0.000044840177,0.0004748111,0.000018811907,0.00030383983,0.0000011907058,0.000015577698,0.00002228439,0.000049513892],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.998686,0.000055238503,0.00056825636,0.00021977122,0.0003066493,0.00016409258],"domain_scores_gemma":[0.99822557,0.00036158686,0.00071977515,0.0002874342,0.00011642509,0.00028918017],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004771623,0.00020832555,0.00033138998,0.00004528108,0.00010550766,0.000015806285,0.00023505745,0.000082582235,0.00045273037],"category_scores_gemma":[0.0009215714,0.00018602678,0.00008722709,0.00012126066,0.00040785072,0.000105471845,0.000053655276,0.0005096517,0.0000017253324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002801728,0.00012857335,0.010225778,0.00051022065,0.00007335614,0.00016442951,0.0002564125,0.000005977474,0.98438805,0.000022390215,0.0002457839,0.0036988326],"study_design_scores_gemma":[0.0008544765,0.000028940676,0.007577409,0.00046594138,0.00019684303,0.0005189656,0.00037939113,0.000026635458,0.989158,0.00012286747,0.0005053598,0.00016521256],"about_ca_topic_score_codex":0.0000121475705,"about_ca_topic_score_gemma":6.3904855e-7,"teacher_disagreement_score":0.009799192,"about_ca_system_score_codex":0.000030510619,"about_ca_system_score_gemma":0.0000910656,"threshold_uncertainty_score":0.75859517},"labels":[],"label_agreement":null},{"id":"W1974233022","doi":"10.1016/j.ejmech.2007.06.017","title":"Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells","year":2007,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Pécsi Tudományegyetem; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; Benzopyran; Stereochemistry; Toxicity; Chemical synthesis; Bicyclic molecule; In vitro; Biochemistry; Organic chemistry","score_opus":0.01982663874555238,"score_gpt":0.2635398785687856,"score_spread":0.2437132398232332,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1974233022","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9757416,0.0008800134,0.021176524,0.0006988691,0.00015626832,0.00030445194,0.000013688606,0.000020534344,0.0010080211],"genre_scores_gemma":[0.994361,0.00017482362,0.0042457846,0.00008850412,0.0009802519,0.0000022240667,0.0000010707718,0.00007037533,0.00007599456],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99724793,0.00025173184,0.00096654065,0.00035944278,0.0007386864,0.00043566411],"domain_scores_gemma":[0.9954113,0.002073041,0.0010010451,0.00029991494,0.0007650658,0.00044966108],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005189353,0.00036136134,0.0010030405,0.00014847361,0.00013423784,0.000021163401,0.00029413818,0.00010398209,0.000053834843],"category_scores_gemma":[0.0027079263,0.0002830319,0.00020149518,0.0002459697,0.0002655634,0.00019822948,0.00007353032,0.00060494913,0.0000022582824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0036772392,0.00034535505,0.00077738316,0.00047336522,0.00040604058,0.0003221161,0.0007147473,0.000008733766,0.98827803,0.0000052104388,0.0004865327,0.004505236],"study_design_scores_gemma":[0.002119938,0.0009923392,0.011613008,0.001121167,0.0005775139,0.0016622919,0.00060348853,0.00012536203,0.98080605,0.00004624866,0.000097928925,0.00023468389],"about_ca_topic_score_codex":0.0000037741422,"about_ca_topic_score_gemma":9.1840275e-7,"teacher_disagreement_score":0.018619344,"about_ca_system_score_codex":0.00015035123,"about_ca_system_score_gemma":0.00030515358,"threshold_uncertainty_score":0.9999622},"labels":[],"label_agreement":null},{"id":"W1975625660","doi":"10.1016/j.ejmech.2015.01.012","title":"Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae)","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institut National Du Cancer; Centre National de la Recherche Scientifique; Agence Universitaire de la Francophonie; Institut National de la Santé et de la Recherche Médicale","keywords":"Gardenia; Flavones; Chemistry; Leishmania; Exudate; Rubiaceae; Trypanosoma brucei; Plasmodium falciparum; Pharmacognosy; Flavonoid; Traditional medicine; Stereochemistry; Botany; Biochemistry; Biological activity; Parasite hosting; Biology; Malaria; In vitro; Chromatography; Immunology; Antioxidant","score_opus":0.013950243412503848,"score_gpt":0.21933306730763677,"score_spread":0.20538282389513293,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1975625660","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98761415,0.009804611,0.00016941335,0.00020475211,0.00009803146,0.000037971855,0.000013666393,0.0000060893867,0.0020513094],"genre_scores_gemma":[0.9973403,0.000549538,0.00066270615,0.000062496285,0.00090521935,2.2466503e-7,0.00001394778,0.00002033533,0.00044523925],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987022,0.00014814672,0.0003967836,0.0002543157,0.00029904928,0.00019948384],"domain_scores_gemma":[0.99895334,0.000069424605,0.00032781943,0.00020249859,0.00011064234,0.0003362456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004531254,0.00022691894,0.00044702127,0.000025235888,0.00003362115,0.00002554024,0.00026025614,0.0000780114,0.000020637612],"category_scores_gemma":[0.00046113893,0.00017552034,0.0001104633,0.00004565393,0.0005120952,0.000013354395,0.00019259378,0.0003343494,6.436518e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002897199,0.000036958703,0.0035899193,0.000044593922,0.00012002082,0.00006952637,0.00017730817,0.0000019359043,0.99324936,4.1333777e-7,0.0012527378,0.0011675059],"study_design_scores_gemma":[0.0013303041,0.0003069483,0.008040638,0.00018170026,0.00007505208,0.00042718294,0.0005883977,0.0000057950706,0.98386496,0.00006942294,0.0049082283,0.00020137308],"about_ca_topic_score_codex":0.000008430146,"about_ca_topic_score_gemma":7.0522754e-7,"teacher_disagreement_score":0.009726139,"about_ca_system_score_codex":0.000017625372,"about_ca_system_score_gemma":0.00009475395,"threshold_uncertainty_score":0.7157512},"labels":[],"label_agreement":null},{"id":"W1976717918","doi":"10.1016/j.ejmech.2010.03.018","title":"Synthesis, antiproliferative activity evaluation and structure–activity relationships of novel aromatic urea and amide analogues of N-phenyl-N′-(2-chloroethyl)ureas","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Amide; Chloroacetyl chloride; Urea; Acylation; Acyl chloride; Acryloyl chloride; Stereochemistry; Carboxamide; Chloride; Proton NMR; Biological activity; Organic chemistry; In vitro; Biochemistry","score_opus":0.022785097053317476,"score_gpt":0.2690680513318553,"score_spread":0.24628295427853783,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1976717918","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9966946,0.0016403932,0.0007295899,0.000094843206,0.00019401751,0.00008938114,0.00003591916,0.000002220375,0.00051902706],"genre_scores_gemma":[0.9978641,0.00036954595,0.00087026355,0.000012392236,0.0008397936,8.990823e-7,0.000008608477,0.00001689776,0.00001748498],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99869275,0.00023656682,0.00038830785,0.00019300061,0.0003660635,0.00012329557],"domain_scores_gemma":[0.9984842,0.00011031127,0.00075542997,0.00021508458,0.00028845438,0.00014652478],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017004083,0.00016648251,0.00035665286,0.00004853785,0.000061612445,0.000010552623,0.00013345401,0.00009180624,0.000015373304],"category_scores_gemma":[0.0018890161,0.0001385866,0.0000732507,0.00006901623,0.00033181233,0.000019652609,0.00005140863,0.00043852863,7.829815e-8],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002830584,0.00007558262,0.0025165295,0.00012351295,0.00011567791,0.0000020911089,0.00018571947,0.000012445738,0.9866663,0.0000038404246,0.000070938666,0.009944309],"study_design_scores_gemma":[0.0011547803,0.00013443684,0.1323633,0.0001250364,0.00026946486,0.00033538914,0.00014811032,0.00011212654,0.8649073,0.000044995588,0.0002924356,0.00011261233],"about_ca_topic_score_codex":0.000008940713,"about_ca_topic_score_gemma":0.000013031757,"teacher_disagreement_score":0.12984678,"about_ca_system_score_codex":0.000008915526,"about_ca_system_score_gemma":0.00016214076,"threshold_uncertainty_score":0.5651398},"labels":[],"label_agreement":null},{"id":"W1982271708","doi":"10.1016/s0223-5234(00)01173-9","title":"Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds","year":2000,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":71,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"","keywords":"Chemistry; Cytotoxicity; Cytotoxic T cell; Mannich base; Stereochemistry; Molecule; Potency; L1210 cells; Mannich reaction; In vitro; Cell culture; Biochemistry; Organic chemistry","score_opus":0.011579992243603093,"score_gpt":0.2088242179880508,"score_spread":0.1972442257444477,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1982271708","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7732342,0.0011444585,0.000002414364,0.00038271092,0.000038896866,0.000010171923,0.0000036238152,0.000023937451,0.22515962],"genre_scores_gemma":[0.99363583,0.0005906717,0.000114483315,0.00008589034,0.0006693265,2.787503e-7,0.0000028020413,0.000022068345,0.004878646],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985313,0.00009407983,0.0005997805,0.00021189918,0.00033198134,0.0002309975],"domain_scores_gemma":[0.99896145,0.00018172602,0.00032870882,0.00018617683,0.000062469226,0.00027945085],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00080508733,0.00020885406,0.0003765858,0.000018874483,0.00009255429,0.000032781216,0.0003280126,0.00008052984,0.015644157],"category_scores_gemma":[0.00019300722,0.00014487324,0.00013783321,0.000073354444,0.00024166894,0.00008554089,0.00004599987,0.00058459054,0.000033346645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021731443,0.00012751887,0.0013854759,0.000087640154,0.000087505716,0.0011459894,0.000091741116,0.0000026680566,0.94670653,0.000001225077,0.0012598187,0.048886575],"study_design_scores_gemma":[0.0044210837,0.00042620866,0.03804468,0.0014626826,0.00031332832,0.019706644,0.00066776987,0.000055517437,0.77885836,0.00019922492,0.15497163,0.0008728597],"about_ca_topic_score_codex":0.000002185725,"about_ca_topic_score_gemma":9.1632025e-8,"teacher_disagreement_score":0.22040166,"about_ca_system_score_codex":0.00003610103,"about_ca_system_score_gemma":0.000035789028,"threshold_uncertainty_score":0.98525566},"labels":[],"label_agreement":null},{"id":"W1984413367","doi":"10.1016/j.ejmech.2010.02.012","title":"Synthesis and cyclooxygenase inhibitory activities of some N-acylhydrazone derivatives of isoxazolo[4,5-d]pyridazin-4(5H)-ones","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":55,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Hacettepe Üniversitesi","keywords":"Chemistry; Cyclooxygenase; Inhibitory postsynaptic potential; Stereochemistry; Bicyclic molecule; Organic chemistry; Enzyme","score_opus":0.010874808349893478,"score_gpt":0.2144071851595968,"score_spread":0.20353237680970332,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1984413367","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99089384,0.0009025883,0.00001629957,0.00022144112,0.000105800355,0.00002153833,0.000028497301,0.000014047196,0.007795926],"genre_scores_gemma":[0.9980602,0.0003510258,0.00044056674,0.000023772209,0.0010003082,9.99654e-7,0.0000014306526,0.000026739723,0.00009492776],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9981851,0.00010765113,0.00081115105,0.00022627866,0.00043985818,0.00022997895],"domain_scores_gemma":[0.9973763,0.0008096222,0.0011799206,0.00026923002,0.00014489297,0.00021998661],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010201249,0.0002638443,0.00070223614,0.000053395208,0.00006248049,0.0000129041455,0.00039089166,0.00011378382,0.0007523985],"category_scores_gemma":[0.0015861412,0.00018788283,0.00020256345,0.00007402834,0.00089803204,0.00017183549,0.0001315941,0.0007040584,0.0000012364793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032230953,0.00033355207,0.0020027605,0.0005066901,0.0001279801,0.00014661031,0.00020841672,6.8290586e-7,0.9771802,0.000008163047,0.00012642442,0.019036204],"study_design_scores_gemma":[0.0005221894,0.00012958022,0.0070838057,0.0005163528,0.0000956866,0.00039818927,0.0011758057,0.0000046346354,0.98895055,0.000050197406,0.0008904525,0.0001825603],"about_ca_topic_score_codex":0.0000049510822,"about_ca_topic_score_gemma":5.307894e-7,"teacher_disagreement_score":0.018853644,"about_ca_system_score_codex":0.00001663141,"about_ca_system_score_gemma":0.00007037202,"threshold_uncertainty_score":0.8238236},"labels":[],"label_agreement":null},{"id":"W1985849639","doi":"10.1016/j.ejmech.2007.11.001","title":"Effects of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans propenoic acid and its ester derivatives on biofilm formation by two oral pathogens, Porphyromonas gingivalis and Streptococcus mutans","year":2007,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Ministero dell'Università e della Ricerca","keywords":"Porphyromonas gingivalis; Biofilm; Streptococcus mutans; Chemistry; Vanillic acid; Microbiology; Bacteria; Organic chemistry; Biology","score_opus":0.014527256171057793,"score_gpt":0.2846116380108805,"score_spread":0.27008438183982275,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1985849639","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99340266,0.0040610903,0.0010734906,0.00014235909,0.00012270942,0.00019144331,0.00005850593,0.000011652685,0.00093611836],"genre_scores_gemma":[0.9987387,0.00025169877,0.00037149776,0.00009554074,0.00020206852,9.465025e-7,0.000021010152,0.000029587263,0.00028893095],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99801993,0.00041626504,0.0006746502,0.00022823505,0.000339228,0.00032171543],"domain_scores_gemma":[0.99873114,0.00020200173,0.00044683146,0.00013173165,0.00024105764,0.00024726204],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018089259,0.00023939057,0.0004209472,0.00009478569,0.00010859103,0.000036974277,0.00022570348,0.00008215583,0.00012291587],"category_scores_gemma":[0.00033212837,0.00018571912,0.0000808166,0.00016218722,0.00027723072,0.00022233714,0.000062706975,0.0006237039,0.000006676812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004529297,0.00009846587,0.0027906287,0.0005906985,0.000093572016,0.001422178,0.0006018407,6.558044e-7,0.9827052,0.000003305301,0.00054044696,0.01070009],"study_design_scores_gemma":[0.002808043,0.0007368983,0.025094861,0.0006140121,0.000082444174,0.0012231625,0.00028768418,0.0000069882617,0.96802646,0.000009772762,0.00093214796,0.00017750802],"about_ca_topic_score_codex":0.0000029325001,"about_ca_topic_score_gemma":0.0000015745338,"teacher_disagreement_score":0.022304233,"about_ca_system_score_codex":0.00003207787,"about_ca_system_score_gemma":0.00003856634,"threshold_uncertainty_score":0.7573406},"labels":[],"label_agreement":null},{"id":"W1986193009","doi":"10.1016/j.ejmech.2013.10.052","title":"Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; Novartis Foundation; Medical Research Council; Merck KGaA; National Cancer Institute; AbbVie; Life Technologies Corporation; GlaxoSmithKline; University of California; Pfizer","keywords":"Chemistry; Diazepine; Kinase; Stereochemistry; Biochemistry; Ring (chemistry); Organic chemistry","score_opus":0.011960522515839948,"score_gpt":0.23079304400279935,"score_spread":0.2188325214869594,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986193009","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9960742,0.002181316,0.00017313044,0.0001253614,0.00021726688,0.00011334043,0.000021874006,0.000004717961,0.0010887749],"genre_scores_gemma":[0.9972085,0.00021065408,0.00074225955,0.00008138269,0.0011615594,0.0000029949051,0.000022551978,0.000034830446,0.0005352973],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986276,0.000080593294,0.000580717,0.0002341118,0.00022564024,0.00025131865],"domain_scores_gemma":[0.99868804,0.00004481884,0.00054772437,0.00026079576,0.00024245046,0.00021619609],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004659522,0.00022584695,0.00037165463,0.000041786483,0.000070508264,0.000022838545,0.0002679709,0.00007332896,0.000060571845],"category_scores_gemma":[0.00027333194,0.00017660116,0.00012750692,0.00004332422,0.00018218615,0.000021480688,0.00010076583,0.00018004986,0.0000011859703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021887061,0.000025486164,0.00164995,0.00029723742,0.00006438326,0.00007101879,0.00012096235,0.0000031083723,0.98561376,0.0000019344898,0.0018858046,0.010047491],"study_design_scores_gemma":[0.0018273818,0.0010756808,0.010851509,0.00020511194,0.00009061529,0.0010448515,0.00082226354,0.000031308773,0.9814727,0.000028560307,0.002340116,0.00020991059],"about_ca_topic_score_codex":0.0000056175427,"about_ca_topic_score_gemma":9.3297473e-7,"teacher_disagreement_score":0.00983758,"about_ca_system_score_codex":0.0000117382515,"about_ca_system_score_gemma":0.00007264728,"threshold_uncertainty_score":0.72015864},"labels":[],"label_agreement":null},{"id":"W1986420914","doi":"10.1016/j.ejmech.2008.03.020","title":"Steroidal lactones as inhibitors of 17β-hydroxysteroid dehydrogenase type 5: Chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities","year":2008,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Steroid; Androgen; Hydroxysteroid dehydrogenase; Testosterone (patch); Enzyme; Lactone; Dehydrogenase; Androgen receptor; IC50; Stereochemistry; Estrogen; Endocrinology; Internal medicine; Prostate cancer; Biochemistry; In vitro; Hormone; Cancer; Biology","score_opus":0.008245590159815654,"score_gpt":0.24026546160801102,"score_spread":0.23201987144819536,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1986420914","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9907305,0.008381839,0.000017223632,0.000039996106,0.00008484087,0.000069301524,0.000007416682,0.000004753261,0.000664095],"genre_scores_gemma":[0.99735034,0.0020150335,0.00020070553,0.000015753105,0.00032782453,9.496894e-7,0.000005261337,0.000035859015,0.000048290756],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99845254,0.00020688317,0.0005238554,0.0002419853,0.00036565078,0.00020908944],"domain_scores_gemma":[0.99876195,0.000077676654,0.00059362827,0.00020341358,0.00011463059,0.00024871537],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000535038,0.00024760774,0.0004569608,0.000059243845,0.000054191678,0.000007585661,0.00017660527,0.0001366863,0.000011234146],"category_scores_gemma":[0.00015427862,0.00020939572,0.00014868472,0.000079808786,0.00056688307,0.0000181519,0.00015787821,0.0004041767,4.5802352e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046151812,0.00014516342,0.0029354915,0.0002128929,0.0002777157,0.00024420844,0.00010532502,0.000005106459,0.9943308,8.4197444e-7,0.00012328784,0.0011576279],"study_design_scores_gemma":[0.0011884295,0.0009463024,0.001088922,0.00026484716,0.00015599762,0.0049898294,0.00015391219,0.000015797032,0.99083304,0.0000020102716,0.00019160596,0.00016930778],"about_ca_topic_score_codex":0.0000032991181,"about_ca_topic_score_gemma":1.5429883e-7,"teacher_disagreement_score":0.0066197887,"about_ca_system_score_codex":0.000020837948,"about_ca_system_score_gemma":0.00023868575,"threshold_uncertainty_score":0.85389096},"labels":[],"label_agreement":null},{"id":"W1987009333","doi":"10.1016/j.ejmech.2006.08.002","title":"Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds","year":2006,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":81,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek","keywords":"Pharmacophore; Chemistry; Stereochemistry; Cytotoxicity; Quantitative structure–activity relationship; Chemical synthesis; Cytotoxic T cell; Structure–activity relationship; In vitro; Biochemistry","score_opus":0.03115288481138271,"score_gpt":0.2069431884188177,"score_spread":0.175790303607435,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1987009333","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98208207,0.004556934,0.00019513661,0.0002114309,0.000053909524,0.000037934133,0.000007006013,0.000024722453,0.012830832],"genre_scores_gemma":[0.9978462,0.0002889573,0.0010119543,0.000018983248,0.0004392704,0.0000014964563,0.0000011418155,0.000032042488,0.0003599479],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9980019,0.00014498133,0.00091143226,0.00028326453,0.00040183382,0.0002566421],"domain_scores_gemma":[0.9982122,0.00042901715,0.00079349667,0.00020387807,0.00018929619,0.00017207737],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013049816,0.0002984212,0.00064113137,0.000044312368,0.000092879745,0.000035249923,0.00029483985,0.000116569936,0.00020096311],"category_scores_gemma":[0.00078286923,0.00020100879,0.000121472585,0.000089517365,0.0006080293,0.00010438523,0.00011177494,0.00044131395,8.441312e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030869682,0.00023704843,0.0012534006,0.0003660401,0.00009426119,0.00014609643,0.000078440906,0.000009336543,0.99337316,0.000003484573,0.000105977735,0.0040240674],"study_design_scores_gemma":[0.0010148588,0.00010565844,0.005304328,0.0010494412,0.00016312966,0.0016007861,0.0003611089,0.00012546734,0.98967427,0.000023183185,0.00033280955,0.0002449399],"about_ca_topic_score_codex":0.000013657033,"about_ca_topic_score_gemma":2.1120704e-7,"teacher_disagreement_score":0.015764112,"about_ca_system_score_codex":0.000038604412,"about_ca_system_score_gemma":0.000058541424,"threshold_uncertainty_score":0.8196901},"labels":[],"label_agreement":null},{"id":"W1988529450","doi":"10.1016/j.ejmech.2012.06.027","title":"Synthesis and selective anticancer activity of steroidal glycoconjugates","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Benemérita Universidad Autónoma de Puebla; Consejo Nacional de Ciencia y Tecnología","keywords":"Diosgenin; Chemistry; Glycoconjugate; Sapogenin; HeLa; Cytotoxicity; Glucosamine; In vitro; Biochemistry; Cancer cell; Stereochemistry; Hydrochloride; Cancer; Organic chemistry","score_opus":0.009828540144815462,"score_gpt":0.2320444920994995,"score_spread":0.22221595195468405,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1988529450","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99249923,0.0032638968,0.00011538335,0.000108411274,0.00006121796,0.00003100975,0.0000074032273,0.0000018228085,0.0039116098],"genre_scores_gemma":[0.99851924,0.0003781316,0.00013378546,0.000040195853,0.0008660568,0.0000011018269,7.7158717e-7,0.000012083295,0.000048635422],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9992703,0.000071939445,0.00021192656,0.00009848538,0.00016661688,0.00018073333],"domain_scores_gemma":[0.9993624,0.000048704547,0.0002662341,0.00008875411,0.0000998013,0.00013410095],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044580188,0.00011892177,0.00022374265,0.000011563112,0.00003484911,0.000004841565,0.000113797585,0.00003440665,0.000017548899],"category_scores_gemma":[0.00025579234,0.00008933171,0.000075667376,0.000038007343,0.00023070825,0.000008982708,0.000087017565,0.00014887232,4.182408e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003274286,0.00007591504,0.0041899337,0.00007031591,0.00014038067,0.0000058147666,0.00007539241,2.912808e-7,0.9864593,5.473823e-7,0.00055948587,0.008095189],"study_design_scores_gemma":[0.0003603941,0.0002114086,0.013379845,0.00008048738,0.000064449334,0.00016308151,0.00023610311,8.3618636e-7,0.9823837,0.0000030276449,0.003023949,0.000092676746],"about_ca_topic_score_codex":0.0000026412915,"about_ca_topic_score_gemma":1.7692865e-7,"teacher_disagreement_score":0.009189911,"about_ca_system_score_codex":0.0000126713885,"about_ca_system_score_gemma":0.000026039721,"threshold_uncertainty_score":0.36428416},"labels":[],"label_agreement":null},{"id":"W1992958404","doi":"10.1016/j.ejmech.2015.01.059","title":"Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"PROTEO; Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Dehydrogenase; Carbamate; Estrogen; Hydroxysteroid dehydrogenase; Stereochemistry; Structure–activity relationship; Biological activity; Lead compound; Quantitative structure–activity relationship; Chemical synthesis; Steroid; Docking (animal); Enzyme; Combinatorial chemistry; Biochemistry; In vitro; Hormone; Endocrinology; Biology","score_opus":0.011932340040250846,"score_gpt":0.24998019373239377,"score_spread":0.23804785369214293,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1992958404","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9913609,0.006176957,0.00043763407,0.00008247272,0.00025799213,0.00010364395,0.00000531993,0.0000060364437,0.0015690378],"genre_scores_gemma":[0.9982525,0.00033479344,0.00027979515,0.000045894783,0.00069243135,5.4808305e-7,0.00002850792,0.000043177137,0.00032232463],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978473,0.00018753814,0.0010123762,0.00024101841,0.00048601977,0.00022573571],"domain_scores_gemma":[0.99752617,0.000022549219,0.0011580316,0.0003494651,0.00040924113,0.00053456443],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009858744,0.00024313372,0.00039348452,0.000069939044,0.00003145787,0.000011815994,0.0004359827,0.00013081622,0.000010315398],"category_scores_gemma":[0.00058666355,0.00020777268,0.00021889083,0.00021007832,0.00022236272,0.000015795506,0.000075939446,0.00033522118,0.000012119755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005664411,0.00011820056,0.00059216196,0.00009718254,0.00025229558,0.00016018694,0.00032797296,0.000121474004,0.99343675,9.488998e-7,0.0034109026,0.0009154886],"study_design_scores_gemma":[0.0023543392,0.0015351379,0.00058109994,0.00025853814,0.0001601821,0.0008045067,0.00056089676,0.000030818428,0.9926419,0.000011645735,0.0008872381,0.00017367226],"about_ca_topic_score_codex":0.000006010943,"about_ca_topic_score_gemma":1.2666756e-7,"teacher_disagreement_score":0.0068916217,"about_ca_system_score_codex":0.000030720385,"about_ca_system_score_gemma":0.00069528917,"threshold_uncertainty_score":0.8472724},"labels":[],"label_agreement":null},{"id":"W1994086798","doi":"10.1016/j.ejmech.2009.02.022","title":"Synthesis and biochemical evaluation of a cyclic RGD oxorhenium complex as new ligand of αVβ3 integrin","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer","keywords":"Chemistry; Ligand (biochemistry); Integrin; Stereochemistry; Combinatorial chemistry; Biochemistry; Receptor","score_opus":0.051718094979470094,"score_gpt":0.3379916634205134,"score_spread":0.2862735684410433,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1994086798","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9800614,0.0020186286,0.000098010205,0.002246846,0.000024728182,0.0000941153,0.000002043763,0.0000052292335,0.015448985],"genre_scores_gemma":[0.9982658,0.00021195783,0.00077198073,0.00013319527,0.0003817147,1.9501478e-7,0.0000044506332,0.000018645143,0.00021207386],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9972156,0.00019159149,0.00078583905,0.00016796326,0.0014655632,0.00017338894],"domain_scores_gemma":[0.99795055,0.0001657578,0.00049908075,0.00023826475,0.0006110838,0.00053524587],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002223702,0.00015172375,0.00049916934,0.00011601298,0.000019827856,0.0000073673036,0.00021984655,0.00005432319,0.0006300052],"category_scores_gemma":[0.0041673877,0.0001174477,0.00013601463,0.0001775014,0.00021042679,0.00003308834,0.000051585423,0.0004970188,0.0000057548623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006969748,0.00015008448,0.0002591105,0.0001790784,0.000068711845,0.00018838081,0.00019018505,0.0000019252282,0.94904995,0.0000013175414,0.0062580053,0.042956263],"study_design_scores_gemma":[0.002682476,0.0007908783,0.015166896,0.0012893538,0.00040680123,0.0024243305,0.00037691675,0.000116077994,0.97586584,0.000051265164,0.0007434919,0.00008567647],"about_ca_topic_score_codex":0.0000051421252,"about_ca_topic_score_gemma":5.780504e-8,"teacher_disagreement_score":0.042870585,"about_ca_system_score_codex":0.00006839496,"about_ca_system_score_gemma":0.0004182702,"threshold_uncertainty_score":0.6898115},"labels":[],"label_agreement":null},{"id":"W1995642225","doi":"10.1016/j.ejmech.2014.07.045","title":"In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Isoquinoline; Stereochemistry; Quinoline; Pharmacophore; Docking (animal); Quantitative structure–activity relationship; In silico; Binding site; Fluorescence; Molecular model; Biochemistry; Organic chemistry","score_opus":0.013628426635313915,"score_gpt":0.2736707834128876,"score_spread":0.26004235677757365,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1995642225","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99482733,0.0034301607,0.0012307562,0.00022146672,0.000118641765,0.0001200486,0.000030079254,0.0000032473624,0.000018285686],"genre_scores_gemma":[0.99542385,0.0011888295,0.002461089,0.00007170895,0.0007620779,0.0000014959292,0.000060551985,0.000020981966,0.000009427532],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985571,0.0001496178,0.0006176007,0.00025370467,0.00023681828,0.00018514533],"domain_scores_gemma":[0.99896437,0.00003225235,0.0005011327,0.00015398819,0.00016130765,0.00018697644],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015443345,0.00015498519,0.00029075614,0.000064932494,0.000068093905,0.000020901221,0.00014555136,0.000053099164,0.00000499397],"category_scores_gemma":[0.00044305355,0.00013774236,0.000080265614,0.000073995885,0.00007463496,0.000020647787,0.00010410032,0.00015451174,5.220022e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042592615,0.00004098837,0.003865077,0.00017212941,0.000037883525,0.000054594922,0.00017087384,0.000019817351,0.988539,7.501999e-7,0.0003448578,0.006328096],"study_design_scores_gemma":[0.0021295354,0.0011452871,0.0077547305,0.0013198127,0.000089333174,0.00016518352,0.0005256725,0.00015238776,0.9854667,0.000044294684,0.0009774843,0.00022958562],"about_ca_topic_score_codex":0.0000037545224,"about_ca_topic_score_gemma":0.0000010971859,"teacher_disagreement_score":0.00609851,"about_ca_system_score_codex":0.000026986776,"about_ca_system_score_gemma":0.00004515137,"threshold_uncertainty_score":0.56169707},"labels":[],"label_agreement":null},{"id":"W1999507887","doi":"10.1016/j.ejmech.2014.09.029","title":"Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Natural Science Foundation of China; St. Francis Xavier University","keywords":"Antimycobacterial; Klebsiella pneumoniae; Chemistry; Oxime; Moiety; Antibacterial activity; In vitro; In vivo; Escherichia coli; Antibacterial agent; Microbiology; Stereochemistry; Antibiotics; Bacteria; Mycobacterium tuberculosis; Medicinal chemistry; Biochemistry; Biology; Tuberculosis; Medicine","score_opus":0.024418843286964063,"score_gpt":0.25702976887683776,"score_spread":0.2326109255898737,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999507887","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.994839,0.00060292,0.003167455,0.00008505484,0.00038457222,0.000061324834,0.000010299433,0.000004279271,0.0008450598],"genre_scores_gemma":[0.99665374,0.00023712155,0.00074177503,0.00007679904,0.0022099246,0.0000013760737,0.00003434697,0.000027393817,0.000017536015],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99833184,0.00035533347,0.00048157762,0.00022269427,0.00044294,0.00016558239],"domain_scores_gemma":[0.99866503,0.000026935917,0.0005328402,0.00019755757,0.00043167348,0.00014598243],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0023472116,0.00017239933,0.0002832087,0.000030576168,0.0000625733,0.000020607333,0.00017628101,0.000090616064,0.0001281813],"category_scores_gemma":[0.00030515878,0.00015201369,0.00008151593,0.0000396647,0.00014731278,0.000015664511,0.00006173715,0.0001889473,7.5399373e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010356606,0.00005775191,0.00026539725,0.000039327464,0.000113805465,0.0000043589553,0.00008694862,0.0000145140675,0.96770936,0.000011741084,0.00006428541,0.03059686],"study_design_scores_gemma":[0.0025261005,0.0011335394,0.008990726,0.00014456104,0.00021388076,0.00028851486,0.00022767902,0.000121028635,0.98223567,0.000047775866,0.003900146,0.00017038369],"about_ca_topic_score_codex":0.000001938089,"about_ca_topic_score_gemma":3.7248617e-7,"teacher_disagreement_score":0.030426476,"about_ca_system_score_codex":0.00002043202,"about_ca_system_score_gemma":0.00013587913,"threshold_uncertainty_score":0.61989385},"labels":[],"label_agreement":null},{"id":"W1999552083","doi":"10.1016/j.ejmech.2010.01.002","title":"Support vector machines: Development of QSAR models for predicting anti-HIV-1 activity of TIBO derivatives","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":66,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Quantitative structure–activity relationship; Support vector machine; Molecular descriptor; Chemistry; Human immunodeficiency virus (HIV); Artificial intelligence; Artificial neural network; Biological system; Nucleoside Reverse Transcriptase Inhibitor; Nucleoside; Pattern recognition (psychology); Machine learning; Stereochemistry; Computational biology; Reverse transcriptase; Computer science; Biochemistry; Virology; Biology","score_opus":0.027803703334390757,"score_gpt":0.29321347119270086,"score_spread":0.2654097678583101,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999552083","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5322993,0.000022253536,0.46648872,0.00011543408,0.00014552327,0.000038456485,0.000005580119,0.000006871193,0.0008778447],"genre_scores_gemma":[0.7790964,0.0000022185757,0.22062537,0.000015320153,0.0002199257,5.410954e-7,0.000002559632,0.000012564848,0.00002510825],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99812514,0.00014317747,0.0007728208,0.0001931959,0.0005929425,0.0001727332],"domain_scores_gemma":[0.9977068,0.00044875304,0.0010390019,0.00023092248,0.0004311516,0.00014338345],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0028521214,0.00015430173,0.00037544945,0.00007212079,0.00005943489,0.000017459213,0.00087302615,0.000028240756,0.000021149355],"category_scores_gemma":[0.0006541193,0.00012982324,0.00012514078,0.0001608431,0.00011550765,0.00034951884,0.00018472286,0.00037732854,5.917108e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012637941,0.00022832978,0.0014002316,0.0004860379,0.00013563942,0.000049701364,0.0036766147,0.0058073746,0.9393942,0.00015622732,0.00022097176,0.048318297],"study_design_scores_gemma":[0.001666658,0.00026035873,0.031902533,0.00039284842,0.000045464523,0.00037768736,0.00016798968,0.09271284,0.87102926,0.00057147944,0.0006200153,0.0002528816],"about_ca_topic_score_codex":5.2947416e-7,"about_ca_topic_score_gemma":1.4164574e-7,"teacher_disagreement_score":0.24679708,"about_ca_system_score_codex":0.000024309946,"about_ca_system_score_gemma":0.0005108533,"threshold_uncertainty_score":0.5294038},"labels":[],"label_agreement":null},{"id":"W1999568458","doi":"10.1016/j.ejmech.2015.02.033","title":"New functionalized mercaptoundecahydrododecaborate derivatives for potential application in boron neutron capture therapy: Synthesis, characterization and dynamic visualization in cells","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Boron Compounds in Chemistry","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"Tanta University","keywords":"Chemistry; Neutron capture; Boron; Characterization (materials science); Visualization; Radiochemistry; Combinatorial chemistry; Nanotechnology; Organic chemistry; Artificial intelligence","score_opus":0.01699503451907729,"score_gpt":0.27409576258775564,"score_spread":0.25710072806867834,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W1999568458","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93343276,0.0015738747,0.062391017,0.0017277984,0.00016331169,0.000267668,0.000009462864,0.000018315915,0.00041578518],"genre_scores_gemma":[0.99679595,0.0005558153,0.0015325237,0.0001330322,0.0005189644,0.0000070089955,0.00010031579,0.000047265603,0.00030913757],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983908,0.00012519358,0.0006686966,0.0002481161,0.00038784463,0.00017935196],"domain_scores_gemma":[0.998742,0.000077340905,0.00051865337,0.00015626459,0.0002692918,0.0002364451],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010768513,0.00019976958,0.0003786471,0.00012090008,0.00002598061,0.000024773484,0.00012707329,0.00008845204,0.00003563995],"category_scores_gemma":[0.00019793845,0.00018068374,0.000054107757,0.00025622232,0.000068489215,0.00016176046,0.000022828894,0.00031718114,0.0000010335586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018198239,0.00012223603,0.0011706151,0.00015920908,0.000034354973,0.000063307416,0.0004330145,0.00010372524,0.9864173,0.000003663571,0.00024021296,0.009432534],"study_design_scores_gemma":[0.04291599,0.0011616151,0.1094542,0.0030660327,0.00045025963,0.0021537351,0.0035647226,0.016605612,0.788187,0.00031360186,0.031033518,0.0010936755],"about_ca_topic_score_codex":0.000006256039,"about_ca_topic_score_gemma":0.0000017117111,"teacher_disagreement_score":0.19823027,"about_ca_system_score_codex":0.00023893251,"about_ca_system_score_gemma":0.00032408698,"threshold_uncertainty_score":0.73680687},"labels":[],"label_agreement":null},{"id":"W2000704821","doi":"10.1016/s0223-5234(01)01294-6","title":"Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds","year":2002,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta; Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Chemistry; Stereochemistry; Cytotoxic T cell; Benzene derivatives; Chemical synthesis; Benzene; Cytotoxicity; Melphalan; Cell culture; In vitro; Organic chemistry; Biochemistry; Chemotherapy","score_opus":0.09538352064319038,"score_gpt":0.3582120489853702,"score_spread":0.2628285283421798,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2000704821","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.91071796,0.008961479,0.00003608893,0.001450419,0.0008328848,0.000054513337,0.00000858894,0.000029611956,0.07790844],"genre_scores_gemma":[0.9936136,0.0021861338,0.00015825457,0.00060952676,0.000754621,4.6195066e-7,0.0000031650598,0.00003330295,0.0026409521],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9980238,0.00048193196,0.0006612548,0.00021794987,0.00029391033,0.00032114825],"domain_scores_gemma":[0.9985788,0.00017985678,0.0004947669,0.00014491526,0.0001499728,0.00045167695],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0013114597,0.00024701594,0.00037056764,0.00007051574,0.00020341188,0.000027695382,0.00036897705,0.00011176811,0.0029099367],"category_scores_gemma":[0.00014244068,0.00020564748,0.00013854723,0.00014846525,0.00039806683,0.0001134844,0.00009268862,0.0012351113,0.00004691175],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027711957,0.00043865733,0.0069566756,0.00015447097,0.00053575897,0.0044040866,0.0009347047,0.000018673032,0.933171,0.000023392346,0.03156764,0.02151782],"study_design_scores_gemma":[0.015333482,0.0013803488,0.037049804,0.0007056006,0.0012713651,0.021377737,0.0014798944,0.0012933903,0.23560625,0.00021310542,0.6830901,0.0011989395],"about_ca_topic_score_codex":8.926108e-7,"about_ca_topic_score_gemma":1.4705448e-7,"teacher_disagreement_score":0.6975647,"about_ca_system_score_codex":0.000046326622,"about_ca_system_score_gemma":0.000027366645,"threshold_uncertainty_score":0.9980015},"labels":[],"label_agreement":null},{"id":"W2005237675","doi":"10.1016/j.ejmech.2009.11.017","title":"A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NOSM University; Laurentian University; Sudbury Regional Hospital","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Cytotoxicity; Derivative (finance); Stereochemistry; Protein kinase B; Tumor cells; Cancer cell; Cancer research; Combinatorial chemistry; Cancer; Pharmacology; In vitro; Biochemistry; Apoptosis; Internal medicine","score_opus":0.006488252363757484,"score_gpt":0.22260760437439314,"score_spread":0.21611935201063565,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2005237675","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9919089,0.0013139064,0.00352454,0.00071138825,0.0002120723,0.00013447502,0.00002948487,0.000015066177,0.002150161],"genre_scores_gemma":[0.9932347,0.00013870571,0.0017780567,0.0018985496,0.0024272315,0.0000022395227,0.0000111261,0.00007517327,0.00043423264],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978022,0.00013203121,0.00058733195,0.0004388954,0.000586245,0.00045331384],"domain_scores_gemma":[0.9981877,0.000036653866,0.00065444206,0.00031214635,0.00034248075,0.0004665829],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007102031,0.00039238983,0.00043361826,0.00005252217,0.00008578211,0.000036859186,0.00045071766,0.00007805257,0.00006163049],"category_scores_gemma":[0.000075159674,0.00031909673,0.00015298939,0.000165514,0.00015029039,0.000012722223,0.00007804204,0.00048457616,0.0000072625016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001050674,0.00010486626,0.0002419017,0.00006871079,0.0000804808,0.00053020025,0.00023090944,0.00020201196,0.96608084,2.1545066e-8,0.030618655,0.0007907301],"study_design_scores_gemma":[0.0018100364,0.0015558393,0.00039420108,0.0006711867,0.000086209395,0.00036518325,0.00040912392,0.000023268398,0.9878825,0.0000011829061,0.0064221043,0.00037916153],"about_ca_topic_score_codex":0.0000031307607,"about_ca_topic_score_gemma":4.477271e-7,"teacher_disagreement_score":0.02419655,"about_ca_system_score_codex":0.00008863186,"about_ca_system_score_gemma":0.00022458307,"threshold_uncertainty_score":0.9999261},"labels":[],"label_agreement":null},{"id":"W2005579401","doi":"10.1016/j.ejmech.2014.09.083","title":"Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Turun Yliopistollinen Keskussairaala; Narodowym Centrum Nauki","keywords":"Indazole; Chemistry; Imidazoline receptor; Methylene; Agonist; Stereochemistry; Selectivity; Chemical synthesis; In vivo; In vitro; Medicinal chemistry; Pharmacology; Receptor; Organic chemistry; Biochemistry","score_opus":0.011846036734406977,"score_gpt":0.21178239043424565,"score_spread":0.19993635369983867,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2005579401","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9960566,0.0009012065,0.001721874,0.000088300454,0.0001010299,0.000040832827,0.000017127115,0.0000064728774,0.0010665485],"genre_scores_gemma":[0.9972765,0.00075417396,0.0010645167,0.000061256564,0.000709117,7.736725e-7,0.000022972446,0.000026460244,0.00008426057],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985422,0.0002656104,0.000484754,0.00024669763,0.00023729683,0.00022342615],"domain_scores_gemma":[0.9987812,0.0001194283,0.0005267152,0.00014847897,0.0002535191,0.00017063293],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010578026,0.00021464592,0.0004088027,0.00006490702,0.0000699777,0.000016088967,0.00021130548,0.000094404684,0.000056593508],"category_scores_gemma":[0.00094753935,0.00016449713,0.00013838665,0.00009687612,0.00017538367,0.000008370616,0.0000950961,0.00026165004,0.0000018791371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003011525,0.00004209496,0.0005206603,0.00005403098,0.00013363958,0.00006872059,0.00008526499,0.00002183461,0.99423397,0.000003550265,0.00049533165,0.004039757],"study_design_scores_gemma":[0.0006386762,0.00087109406,0.0009809149,0.00019854911,0.00008459177,0.0003600194,0.0004129414,0.000040006737,0.9944941,0.00001638124,0.001731335,0.00017139601],"about_ca_topic_score_codex":0.0000025128222,"about_ca_topic_score_gemma":2.593107e-7,"teacher_disagreement_score":0.0038683608,"about_ca_system_score_codex":0.000018500506,"about_ca_system_score_gemma":0.000041621137,"threshold_uncertainty_score":0.67079985},"labels":[],"label_agreement":null},{"id":"W2006305604","doi":"10.1016/j.ejmech.2009.07.014","title":"Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Research Nova Scotia","keywords":"Chemistry; Purine; Imipramine; Behavioural despair test; Stereochemistry; Bicyclic molecule; Tricyclic; Theophylline; Amide; Anxiolytic; Pharmacology; Receptor; Antidepressant; Biochemistry; Anxiety; Enzyme","score_opus":0.05578637195318387,"score_gpt":0.31123719354497525,"score_spread":0.2554508215917914,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2006305604","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97787875,0.002515275,0.00005208814,0.0008414047,0.00003330755,0.0000412709,0.0000034757627,0.000012751522,0.018621702],"genre_scores_gemma":[0.99860716,0.00038613915,0.00032932818,0.00006893879,0.0005634583,0.000001381322,0.000003228386,0.0000091572265,0.00003122481],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99780476,0.00030782932,0.0007146468,0.00018809027,0.00082640344,0.00015828057],"domain_scores_gemma":[0.99820566,0.00035776137,0.0007195904,0.00012234192,0.00043924616,0.00015540137],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0034989892,0.0001727607,0.00035441908,0.000033411776,0.00005340701,0.000011524083,0.0002491835,0.000066351175,0.002529681],"category_scores_gemma":[0.0025832672,0.0001175441,0.00011290442,0.00007985385,0.00017471648,0.000077115736,0.000039462273,0.00029209926,0.0000022327679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00043003538,0.00018767997,0.00037829336,0.000060517097,0.00006552875,0.00005262459,0.00009651218,0.000051970816,0.83436465,0.0000018943897,0.00025998693,0.16405033],"study_design_scores_gemma":[0.0013503801,0.00038147753,0.03487582,0.00048345828,0.00056566164,0.00039040134,0.00048370945,0.00079435733,0.9601099,0.00015677458,0.0002567125,0.00015136962],"about_ca_topic_score_codex":2.581803e-7,"about_ca_topic_score_gemma":8.147529e-9,"teacher_disagreement_score":0.16389896,"about_ca_system_score_codex":0.00005168695,"about_ca_system_score_gemma":0.000066742985,"threshold_uncertainty_score":0.99838215},"labels":[],"label_agreement":null},{"id":"W2010112543","doi":"10.1016/j.ejmech.2012.09.007","title":"Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Plant chemical constituents analysis","field":"Agricultural and Biological Sciences","cited_by":57,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ryerson University","keywords":"Cytotoxicity; Chemistry; Glioma; Apoptosis; Cytotoxic T cell; Methylenedioxy; Cell culture; Stereochemistry; Reactive oxygen species; IC50; In vitro; Biochemistry; Cancer research; Biology; Organic chemistry; Genetics","score_opus":0.012987835792586786,"score_gpt":0.19433130793076395,"score_spread":0.18134347213817717,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2010112543","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9962622,0.0011129972,0.000008949219,0.00027762467,0.00006827754,0.000027993827,0.000037128888,0.000010001829,0.002194837],"genre_scores_gemma":[0.99855965,0.00020930843,0.0000651936,0.00007083025,0.0009792382,3.7311185e-7,0.00004196171,0.000001809595,0.00007165433],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987328,0.0001304166,0.00041462027,0.00016552096,0.00031933255,0.00023729996],"domain_scores_gemma":[0.99909896,0.00013597759,0.00039785457,0.000037931397,0.00008522725,0.00024407785],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00058290455,0.00016026122,0.00027928723,0.000022653221,0.00005979233,0.000026713476,0.00021212989,0.000062665924,0.0002471874],"category_scores_gemma":[0.00017150132,0.00007061433,0.00007731959,0.00027374414,0.00009840544,0.0001847675,0.00006435607,0.00041407585,0.000004174021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005970818,0.000102836646,0.015106062,0.000008003115,0.00003098205,0.000024141636,0.000110035,5.7627017e-7,0.98119813,1.3206518e-7,0.0010389597,0.0023204086],"study_design_scores_gemma":[0.00030328167,0.000049797978,0.066780135,0.00006935997,0.000053424996,0.00008211055,0.00050306995,0.0000027140804,0.93074834,0.0000038361286,0.0012708667,0.0001330352],"about_ca_topic_score_codex":0.000074626674,"about_ca_topic_score_gemma":0.000008347062,"teacher_disagreement_score":0.05167407,"about_ca_system_score_codex":0.00005937968,"about_ca_system_score_gemma":0.0000063145244,"threshold_uncertainty_score":0.2879569},"labels":[],"label_agreement":null},{"id":"W2013779256","doi":"10.1016/j.ejmech.2007.03.010","title":"Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells","year":2007,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":96,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology; Canada Foundation for Innovation","keywords":"Chemistry; Cytotoxicity; Stereochemistry; Cytotoxic T cell; Aryl; Toxicity; Chemical synthesis; Selectivity; In vitro; Biochemistry; Organic chemistry","score_opus":0.018747394352082114,"score_gpt":0.24459703901547114,"score_spread":0.22584964466338903,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013779256","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99089694,0.0008511582,0.001740222,0.00020547243,0.00008692247,0.000048538543,0.00003798665,0.000021698761,0.0061110333],"genre_scores_gemma":[0.9978071,0.00014466638,0.0005138448,0.00014887603,0.0010261794,0.0000011298175,0.0000060223556,0.000030948446,0.00032126554],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99812716,0.00007647255,0.00068753306,0.00032300162,0.00035779556,0.00042804712],"domain_scores_gemma":[0.99783796,0.0008320842,0.00062313187,0.0001599695,0.00017561729,0.00037122332],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0024052763,0.00028454946,0.00049329945,0.0000307132,0.00018549427,0.000039858107,0.00033523882,0.00010316867,0.00021631575],"category_scores_gemma":[0.00081122963,0.00020036667,0.00019533638,0.00009214995,0.00020978888,0.00009542198,0.00007510065,0.0005462731,0.0000017528239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047078973,0.00014296353,0.0013393773,0.0001823783,0.00008488812,0.00024730025,0.00011379873,0.000001406731,0.988936,0.0000016560658,0.0012141549,0.0072652563],"study_design_scores_gemma":[0.00090418785,0.00021270159,0.0014296568,0.00026668314,0.00008775126,0.00045311876,0.0006381583,0.0000115810735,0.99051094,0.00002605958,0.005213375,0.00024577597],"about_ca_topic_score_codex":0.0000036336678,"about_ca_topic_score_gemma":6.9181567e-7,"teacher_disagreement_score":0.00701948,"about_ca_system_score_codex":0.00009351044,"about_ca_system_score_gemma":0.000046730358,"threshold_uncertainty_score":0.8170716},"labels":[],"label_agreement":null},{"id":"W2013816495","doi":"10.1016/j.ejmech.2005.01.001","title":"The cytotoxic activity of ursolic acid derivatives","year":2005,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Ursolic acid; Chemistry; Cytotoxicity; HeLa; Stereochemistry; Dimer; Terpene; Cytotoxic T cell; Amino acid; Biochemistry; In vitro; Organic chemistry","score_opus":0.009113986984742245,"score_gpt":0.23175206478227234,"score_spread":0.2226380777975301,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2013816495","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9901019,0.003939846,0.00019848734,0.001866327,0.000088831504,0.000030296158,0.0000033005476,0.0000024093051,0.0037686222],"genre_scores_gemma":[0.9967856,0.0006582922,0.0002943742,0.0000796829,0.001559315,2.9903794e-7,0.0000012559121,0.000015616044,0.00060559594],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990052,0.00015220199,0.00031034037,0.00012383437,0.0002446366,0.00016377044],"domain_scores_gemma":[0.99906105,0.000042185442,0.00043186822,0.00024064138,0.00013337296,0.00009088128],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00087302126,0.00012403673,0.00017229829,0.000013684067,0.000086743115,0.000011748359,0.00036889908,0.00003661916,0.000028552184],"category_scores_gemma":[0.00046262814,0.00007721652,0.00013888015,0.000052464366,0.00025422426,0.0000078375315,0.00007052092,0.00024686824,0.000001811427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002474218,0.000037447633,0.00005692035,0.000019897376,0.00007710451,0.000009940374,0.000056848447,0.0000048205184,0.9560089,0.0000015786078,0.001614839,0.041864254],"study_design_scores_gemma":[0.00033500994,0.0001951774,0.0012532002,0.00004235442,0.000023724895,0.00020526933,0.0001907946,0.000003594347,0.95295525,0.000004878018,0.044711497,0.00007926682],"about_ca_topic_score_codex":5.830276e-7,"about_ca_topic_score_gemma":4.6615213e-7,"teacher_disagreement_score":0.043096658,"about_ca_system_score_codex":0.000014992833,"about_ca_system_score_gemma":0.00006658703,"threshold_uncertainty_score":0.31487983},"labels":[],"label_agreement":null},{"id":"W2014724289","doi":"10.1016/j.ejmech.2014.02.037","title":"Antibacterial properties and mode of action of new triaryl butene citrate compounds","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Enterococcus faecalis; Antibacterial activity; Listeria monocytogenes; Staphylococcus aureus; Efflux; Antimicrobial; Hemolysis; Escherichia coli; Mode of action; Antibacterial agent; Microbiology; Bacteria; Biochemistry; Antibiotics; Organic chemistry","score_opus":0.057503795081458225,"score_gpt":0.2463841025985679,"score_spread":0.18888030751710969,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2014724289","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99240583,0.0002172135,0.0001276933,0.00016236624,0.000076350196,0.000012709375,0.000004817742,0.0000068172867,0.0069861766],"genre_scores_gemma":[0.9983158,0.00015983364,0.0002162655,0.000012296146,0.0011174445,7.8284955e-8,0.000002222273,0.000011040637,0.00016498652],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99883866,0.00008591077,0.00057581096,0.0001218913,0.00025904243,0.000118682416],"domain_scores_gemma":[0.99878013,0.00008924425,0.000745148,0.00012773991,0.00011620437,0.00014152561],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006574182,0.00013433189,0.00043603088,0.000018146391,0.000026455546,0.000010517833,0.00020061212,0.00005394817,0.0001916776],"category_scores_gemma":[0.00039444983,0.00008542938,0.00010390695,0.00003908492,0.0001780113,0.000065594344,0.00004359851,0.00024404196,5.338638e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00086711114,0.000090231275,0.000830132,0.00028795225,0.000055642773,0.000010614322,0.00008481283,0.0000028577942,0.97854215,0.0000011121867,0.00013416959,0.019093202],"study_design_scores_gemma":[0.0013064723,0.00015632634,0.0020631016,0.00046016803,0.0000696189,0.00019662555,0.00013739133,0.000050088223,0.99394864,0.00002715047,0.0014949491,0.00008949569],"about_ca_topic_score_codex":0.000011589064,"about_ca_topic_score_gemma":2.1377886e-7,"teacher_disagreement_score":0.019003706,"about_ca_system_score_codex":0.000014302867,"about_ca_system_score_gemma":0.000048377602,"threshold_uncertainty_score":0.3483709},"labels":[],"label_agreement":null},{"id":"W2015264243","doi":"10.1016/j.ejmech.2015.03.067","title":"Towards small molecule inhibitors of mono-ADP-ribosyltransferases","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Structural Genomics Consortium; Cancerfonden; Svenska Forskningsrådet Formas; Vetenskapsrådet; Stiftelsen för Strategisk Forskning","keywords":"ADP-ribosylation; PARP1; Chemistry; Poly ADP ribose polymerase; Diphtheria toxin; Small molecule; Transferase; Polymerase; Biochemistry; Intracellular; DNA damage; DNA; Enzyme; Toxin; NAD+ kinase","score_opus":0.047623411694460153,"score_gpt":0.28398203375976977,"score_spread":0.2363586220653096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2015264243","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9510791,0.003562935,0.0012740474,0.0019216103,0.0003502146,0.0000833155,0.000009031177,0.00002365113,0.041696142],"genre_scores_gemma":[0.99634475,0.0002279474,0.00095243717,0.00045494872,0.0016886594,8.3224467e-7,0.0000071424192,0.000046997222,0.00027630365],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99778104,0.00013791278,0.00090187695,0.00016289449,0.0007951881,0.00022108313],"domain_scores_gemma":[0.99797654,0.0000368832,0.0004591169,0.00025958734,0.0006558449,0.0006120502],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013300579,0.00020395256,0.0005118418,0.000088361136,0.000022148995,0.000008348449,0.00024106966,0.000050734732,0.00029152448],"category_scores_gemma":[0.00026900333,0.00016481648,0.00022191621,0.00019591548,0.0002254184,0.00006168944,0.000026795231,0.0005334553,0.000011099623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021801626,0.0004044184,0.0031052125,0.0004842601,0.0003231665,0.003489448,0.0017627801,0.000040522773,0.9431708,0.000009087687,0.02737484,0.017655306],"study_design_scores_gemma":[0.007147952,0.0013029183,0.0010057724,0.0011470466,0.00018889568,0.0028955557,0.0013888313,0.0000065205045,0.97108006,0.000032882774,0.0136440145,0.00015955773],"about_ca_topic_score_codex":0.0000066826,"about_ca_topic_score_gemma":2.1154577e-7,"teacher_disagreement_score":0.04526568,"about_ca_system_score_codex":0.00013266571,"about_ca_system_score_gemma":0.00060941617,"threshold_uncertainty_score":0.6721021},"labels":[],"label_agreement":null},{"id":"W2015674550","doi":"10.1016/j.ejmech.2014.07.090","title":"The use of nanopore analysis for discovering drugs which bind to α-synuclein for treatment of Parkinson's disease","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Parkinson Society Canada; University of Saskatchewan","keywords":"Chemistry; Neuroprotection; Nicotine; Parkinson's disease; Curcumin; Pharmacology; Alpha-synuclein; Folding (DSP implementation); Biochemistry; Stereochemistry; Neuroscience; Disease; Internal medicine; Psychology; Medicine","score_opus":0.03290119849889438,"score_gpt":0.2705610952976319,"score_spread":0.2376598967987375,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2015674550","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9897049,0.0006623374,0.007993038,0.0008942114,0.000090991,0.00033256755,0.00014168321,0.0000059178014,0.00017434792],"genre_scores_gemma":[0.9962933,0.00017960065,0.002628702,0.00006114774,0.0003383352,0.000011753105,0.00003463557,0.00003654646,0.00041600157],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9983731,0.00007495667,0.00065648666,0.00021449287,0.00044243928,0.00023852145],"domain_scores_gemma":[0.9977255,0.00031994935,0.0006294098,0.00037429194,0.0004179954,0.0005328815],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006149636,0.00020970522,0.00063438126,0.000098057404,0.00009378205,0.000018623175,0.00017114582,0.000023221211,0.000019855686],"category_scores_gemma":[0.0006449757,0.00012534743,0.00054548826,0.0002546432,0.00006636016,0.000051820865,0.000025926704,0.000052626183,7.525819e-7],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.07356647,0.008547353,0.14071742,0.004438815,0.033544954,0.0011171416,0.005935489,0.005240121,0.37228146,0.00024529028,0.007316636,0.34704885],"study_design_scores_gemma":[0.021323185,0.007977379,0.0948195,0.0015825052,0.021200908,0.00007457162,0.0012099621,0.0029267685,0.20146853,0.00007981619,0.64686245,0.00047444887],"about_ca_topic_score_codex":0.0000043636264,"about_ca_topic_score_gemma":0.0000019888546,"teacher_disagreement_score":0.6395458,"about_ca_system_score_codex":0.00009061095,"about_ca_system_score_gemma":0.00014196831,"threshold_uncertainty_score":0.51115197},"labels":[],"label_agreement":null},{"id":"W2016934755","doi":"10.1016/j.ejmech.2010.07.001","title":"Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Engineering and Physical Sciences Research Council","keywords":"Tetralones; Chemistry; Stereochemistry; IC50; Trifluoromethyl; In vitro; Organic chemistry; Biochemistry","score_opus":0.00537039121866745,"score_gpt":0.2181966149287023,"score_spread":0.21282622371003485,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2016934755","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9945555,0.0037339702,0.00015151205,0.00015362795,0.00027344556,0.00006100102,0.000008122036,0.000007676108,0.0010551509],"genre_scores_gemma":[0.99742913,0.00080376543,0.0009595009,0.000021273143,0.0006994761,8.824815e-7,0.000005086319,0.000031377793,0.000049531973],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99864614,0.00016725411,0.00043977253,0.00025731692,0.00027457136,0.0002149687],"domain_scores_gemma":[0.9987105,0.000096579424,0.0004590076,0.00024594026,0.00017347153,0.000314465],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010879405,0.00023634502,0.00036504838,0.00006209169,0.000082958926,0.000018917275,0.00022366938,0.00017410591,0.00002134475],"category_scores_gemma":[0.00074462174,0.00019444706,0.00011548383,0.00009332047,0.00049645366,0.0000172984,0.000107010084,0.00068874116,0.0000010490265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031281955,0.00007484965,0.0013487191,0.00013512492,0.00015325414,0.00022072079,0.00006346497,0.0000042518222,0.9884272,0.000004786105,0.00021053503,0.009044271],"study_design_scores_gemma":[0.001024661,0.00019805641,0.009468337,0.00019609368,0.00016914487,0.0017126974,0.00007478946,0.000012686435,0.9856756,0.00000718962,0.0012714264,0.00018934606],"about_ca_topic_score_codex":0.00000553449,"about_ca_topic_score_gemma":0.0000014738569,"teacher_disagreement_score":0.008854925,"about_ca_system_score_codex":0.0000073504452,"about_ca_system_score_gemma":0.00010556101,"threshold_uncertainty_score":0.7929321},"labels":[],"label_agreement":null},{"id":"W2020181398","doi":"10.1016/j.ejmech.2010.07.030","title":"E-2-[3-(3,4-Dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1,4-dioxide: A lead antitubercular agent which alters mitochondrial respiration in rat liver","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Chemistry; Propenyl; Respiration; Stereochemistry; Medicinal chemistry","score_opus":0.030969637768843726,"score_gpt":0.26663977310889947,"score_spread":0.23567013534005574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2020181398","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9857801,0.00065936765,0.00026032198,0.00086796004,0.0007836177,0.000087009284,0.0000048924576,0.000028937613,0.0115277795],"genre_scores_gemma":[0.99372256,0.00020018153,0.0014687402,0.0002301769,0.00395194,0.0000032273974,0.000023100012,0.000045722332,0.00035435316],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99649864,0.00031328286,0.001346529,0.00044621987,0.0009885639,0.00040675196],"domain_scores_gemma":[0.99774075,0.00018322852,0.00083835627,0.00044851372,0.0004872195,0.00030193685],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0029533575,0.0003533392,0.00054696103,0.00009146907,0.00009675201,0.000070280985,0.0007036253,0.00020103196,0.0021451476],"category_scores_gemma":[0.0029711402,0.00026287662,0.00023581038,0.00026818857,0.00018342056,0.00020345474,0.00010552374,0.0015496564,0.000047897476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005159319,0.00017565857,0.0009978792,0.00012741055,0.000048149075,0.00083498604,0.00017063088,0.000055787506,0.98104775,0.000003463168,0.0010428524,0.014979502],"study_design_scores_gemma":[0.0035555128,0.00024269294,0.0020412817,0.0006198723,0.0001571727,0.00076863763,0.00026743652,0.00050847325,0.9681104,0.00004067969,0.023230266,0.00045759897],"about_ca_topic_score_codex":0.000019890653,"about_ca_topic_score_gemma":0.000022676937,"teacher_disagreement_score":0.022187412,"about_ca_system_score_codex":0.00011419952,"about_ca_system_score_gemma":0.0001920881,"threshold_uncertainty_score":0.99998236},"labels":[],"label_agreement":null},{"id":"W2022639990","doi":"10.1016/j.ejmech.2009.03.016","title":"Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: Synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Uranyl; Bacillus subtilis; Antibacterial activity; Copper; Ligand (biochemistry); Octahedron; Crystallography; Escherichia coli; Nuclear chemistry; Magnetic susceptibility; Octahedral molecular geometry; Stereochemistry; Crystal structure; Bacteria; Organic chemistry; Biochemistry; Ion","score_opus":0.013227446400718601,"score_gpt":0.21003248386725748,"score_spread":0.19680503746653888,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2022639990","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99520874,0.00034053906,0.00002251771,0.0027865055,0.000059695278,0.00019571157,0.0000071875024,0.000012266794,0.0013668162],"genre_scores_gemma":[0.9984614,0.00029955234,0.00015565101,0.0004086796,0.00052475027,0.0000010494665,0.00000298296,0.000027312226,0.00011861263],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99828017,0.0003107135,0.00048641505,0.00021758613,0.00049833173,0.00020680741],"domain_scores_gemma":[0.9984343,0.00033769506,0.00057713967,0.00023421673,0.00020901886,0.00020763882],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001022539,0.00027054857,0.00067626574,0.000053975473,0.00019978301,0.000028366276,0.00019283943,0.00004461135,0.00004588394],"category_scores_gemma":[0.0005415115,0.00014543105,0.00007578282,0.000105455794,0.0003104746,0.00009848618,0.00005946702,0.00044713126,8.787758e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00214544,0.00008850577,0.00030508902,0.0005394843,0.000107968546,0.0001427487,0.00040158193,2.608519e-7,0.9904938,0.000006550296,0.0002492275,0.005519389],"study_design_scores_gemma":[0.0013203166,0.0022769445,0.06639748,0.002600018,0.00030549944,0.00092283305,0.0000612834,0.000022482696,0.9254965,0.000008208007,0.0004437309,0.0001447023],"about_ca_topic_score_codex":0.0000028362654,"about_ca_topic_score_gemma":9.286991e-8,"teacher_disagreement_score":0.066092394,"about_ca_system_score_codex":0.000046434358,"about_ca_system_score_gemma":0.00013068497,"threshold_uncertainty_score":0.5930506},"labels":[],"label_agreement":null},{"id":"W2023431192","doi":"10.1016/j.ejmech.2014.09.090","title":"All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University; Acadia University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Nova Scotia Health Research Foundation","keywords":"Chemistry; Curcumin; Cytotoxicity; Stereochemistry; Potency; Quantitative structure–activity relationship; In vitro; IC50; Cell culture; Pharmacology; Topoisomerase; Biochemistry","score_opus":0.01100289641984392,"score_gpt":0.24270160469090807,"score_spread":0.23169870827106415,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2023431192","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9607094,0.002163551,0.0209363,0.0012383293,0.0009096215,0.000083769904,0.00001681785,0.000021090325,0.013921099],"genre_scores_gemma":[0.99276984,0.0007989983,0.0010365397,0.0013197331,0.0030381854,0.000001163187,0.00003264774,0.00008667878,0.00091624004],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978804,0.00017591016,0.00069018774,0.00034553473,0.0004970374,0.00041094047],"domain_scores_gemma":[0.9983963,0.00004192229,0.00048348907,0.0004059991,0.00026671324,0.0004055948],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0012473349,0.00034297947,0.0004056636,0.00005173033,0.00009122688,0.000038290378,0.0006034179,0.00011156976,0.00015398902],"category_scores_gemma":[0.00025859004,0.0003008012,0.00028327832,0.00009849377,0.00015785897,0.000008466658,0.00008158589,0.000406153,0.000014091002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004031965,0.00008952063,0.000066981,0.00007912311,0.00017007803,0.000148244,0.00014104146,0.00005343423,0.9878192,0.000028609762,0.002152974,0.008847627],"study_design_scores_gemma":[0.0016913919,0.0008061373,0.00010002797,0.00010556727,0.00013693831,0.0008165368,0.00014879393,0.000027827702,0.62143075,0.000036069265,0.3744523,0.00024766696],"about_ca_topic_score_codex":0.000003269652,"about_ca_topic_score_gemma":9.656162e-7,"teacher_disagreement_score":0.3722993,"about_ca_system_score_codex":0.000026339767,"about_ca_system_score_gemma":0.00018303194,"threshold_uncertainty_score":0.9999444},"labels":[],"label_agreement":null},{"id":"W2026116352","doi":"10.1016/j.ejmech.2008.01.044","title":"Design and synthesis of bisubstrate inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Overview and perspectives","year":2008,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Wilfrid Laurier University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Chemistry; Cofactor; Hydroxysteroid dehydrogenase; Estrone; Enzyme; Steroid; Hydroxysteroid Dehydrogenases; Dehydrogenase; NAD+ kinase; Biochemistry; Stereochemistry; Estrogen; Reductase; Hydroxysteroid; Enzyme inhibitor; Hormone; Endocrinology; Biology","score_opus":0.09261831080319172,"score_gpt":0.30508368167747457,"score_spread":0.21246537087428286,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026116352","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.014208948,0.98497367,0.000025855863,0.00006702707,0.000033866927,0.00013709598,0.0000062680965,0.0000045840206,0.0005426862],"genre_scores_gemma":[0.03185282,0.967466,0.00032246203,0.000011893297,0.00020553898,4.5271335e-7,0.000004571237,0.000046287638,0.00008998065],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9977466,0.00029750777,0.0011051997,0.00020529158,0.00051180884,0.00013359047],"domain_scores_gemma":[0.99767256,0.00026828548,0.0012535179,0.00017620862,0.0003423778,0.00028705894],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00081747706,0.0002987057,0.0018224844,0.00012277701,0.000031318064,0.000005190053,0.00011564167,0.000106620995,0.00004503718],"category_scores_gemma":[0.00048066815,0.00020360528,0.00023546776,0.00018180694,0.00033896216,0.000041536066,0.000039047238,0.00043001035,0.0000014694945],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005216516,0.0003682274,0.000024490042,0.03705313,0.0012460386,0.0027741662,0.00064814836,0.0000015034698,0.037956405,0.0000026508737,0.0034245045,0.9159791],"study_design_scores_gemma":[0.0042282776,0.002755281,0.00024290303,0.2066059,0.00835953,0.08236835,0.0010652895,0.0000542879,0.036447126,0.000006240136,0.65701735,0.00084944186],"about_ca_topic_score_codex":9.1315815e-7,"about_ca_topic_score_gemma":1.4420567e-8,"teacher_disagreement_score":0.91512966,"about_ca_system_score_codex":0.0000458654,"about_ca_system_score_gemma":0.0003097078,"threshold_uncertainty_score":0.8302782},"labels":[],"label_agreement":null},{"id":"W2026846560","doi":"10.1016/j.ejmech.2007.04.017","title":"Bioactivity of novel transition metal complexes of N′-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide","year":2007,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"","keywords":"Chemistry; Hydrazide; Ligand (biochemistry); Benzoic acid; Stereochemistry; Electron paramagnetic resonance; Mössbauer spectroscopy; Metal; Medicinal chemistry; Nuclear chemistry; Crystallography; Receptor; Organic chemistry; Nuclear magnetic resonance; Biochemistry","score_opus":0.05093563858487379,"score_gpt":0.2844594770950263,"score_spread":0.2335238385101525,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2026846560","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96336627,0.0024888287,0.018483128,0.00029903676,0.00013510148,0.000084076084,0.000016092978,0.000011547644,0.015115923],"genre_scores_gemma":[0.99195254,0.00007558111,0.0071675135,0.00011435926,0.00054733903,1.886397e-7,0.000006413353,0.00003529677,0.00010076661],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99712396,0.00017864542,0.0013696096,0.0001800838,0.0008899978,0.00025772885],"domain_scores_gemma":[0.9977159,0.00021915455,0.001052065,0.00028552226,0.0004529084,0.0002744853],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0044864807,0.00023890832,0.00093676534,0.00014668702,0.00004725792,0.0000060227553,0.00025942302,0.000058678062,0.00031381927],"category_scores_gemma":[0.00061416166,0.0001727161,0.00042039552,0.00021560332,0.0003758278,0.00011288923,0.0000376291,0.00053598685,0.0000025695788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016367856,0.00045168665,0.00013185735,0.0007362192,0.00027049144,0.00013371489,0.0005420824,0.000008145665,0.9893863,0.000019724357,0.000096528536,0.0065864283],"study_design_scores_gemma":[0.0023508698,0.00091321,0.0061477725,0.0010387186,0.00051669404,0.0017063612,0.00085718493,0.000042460906,0.98502314,0.000021974236,0.001242657,0.00013896929],"about_ca_topic_score_codex":0.000010810072,"about_ca_topic_score_gemma":7.1945084e-7,"teacher_disagreement_score":0.028586276,"about_ca_system_score_codex":0.00004153278,"about_ca_system_score_gemma":0.0001122012,"threshold_uncertainty_score":0.70431584},"labels":[],"label_agreement":null},{"id":"W2029346418","doi":"10.1016/j.ejmech.2015.04.026","title":"Identification of an anti-inflammatory derivative with anti-cancer potential: The impact of each of its structural components on inflammatory responses in macrophages and bladder cancer cells","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Chicoutimi; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Cancer; Inflammation; Macrophage; Cancer research; Lipopolysaccharide; Tumor necrosis factor alpha; Motility; Bladder cancer; Cancer cell; Pharmacology; Immunology; In vitro; Biochemistry; Medicine; Cell biology; Internal medicine; Biology","score_opus":0.019344635039581327,"score_gpt":0.2839423369620676,"score_spread":0.2645977019224863,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2029346418","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9879308,0.011626758,0.000006589564,0.00004152248,0.0001659116,0.00011750304,0.000040450774,0.0000027640267,0.00006772364],"genre_scores_gemma":[0.9995001,0.00028688172,0.0000062484814,0.000003785722,0.000084601226,0.0000010005093,0.0000041997664,0.000015517819,0.00009766559],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99810207,0.0007405458,0.0007133329,0.00016288344,0.00014894668,0.00013224343],"domain_scores_gemma":[0.99788725,0.000060168884,0.001343988,0.00021956826,0.00044617354,0.00004283137],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00121492,0.00015373078,0.0003961444,0.000077448276,0.000033529308,0.0000048299903,0.00025352024,0.000048535676,0.000047364487],"category_scores_gemma":[0.0001000474,0.00008931419,0.000060171154,0.00008834541,0.00045249079,0.000113655595,0.000035692843,0.00029302077,8.224009e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011919126,0.000049063357,0.03677238,0.0001881855,0.0002930048,0.00004952131,0.0020699555,0.00059206923,0.9583272,7.9654683e-7,0.00005730234,0.0004086626],"study_design_scores_gemma":[0.0012113964,0.00023615979,0.3873486,0.0005433783,0.000040020943,0.00012580985,0.0007097262,0.0000027389403,0.6097217,0.0000020916555,0.000005543744,0.00005285672],"about_ca_topic_score_codex":0.000025539213,"about_ca_topic_score_gemma":7.158604e-7,"teacher_disagreement_score":0.3505762,"about_ca_system_score_codex":0.00003574852,"about_ca_system_score_gemma":0.0001785095,"threshold_uncertainty_score":0.3642127},"labels":[],"label_agreement":null},{"id":"W2029639743","doi":"10.1016/j.ejmech.2011.12.002","title":"Binding sites of retinol and retinoic acid with serum albumins","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Retinoic acid; Retinol; Biochemistry; Serum albumin; Vitamin","score_opus":0.017334101964469065,"score_gpt":0.21803377819545852,"score_spread":0.20069967623098944,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2029639743","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9896003,0.0012712006,0.000294376,0.00008287862,0.000029203007,0.000021797186,0.0000036105682,0.0000021585956,0.008694469],"genre_scores_gemma":[0.9979619,0.00051025714,0.0009684382,0.000046274734,0.00025503556,3.1538139e-7,0.0000032296475,0.000011594441,0.00024294898],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9991762,0.000051362385,0.0003273538,0.00013322201,0.00019123143,0.00012062802],"domain_scores_gemma":[0.9991181,0.000007083829,0.0004186661,0.00014700023,0.00021268932,0.000096460855],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044930473,0.00011055235,0.00019066426,0.000030271402,0.0000443044,0.000005490345,0.00015940418,0.000030671643,0.0000923897],"category_scores_gemma":[0.00012841466,0.00007884666,0.00007150981,0.00006762639,0.0001743726,0.0000059158256,0.00006887893,0.00017889157,0.0000016924649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031338996,0.00002921457,0.016938562,0.00005414529,0.00018096641,0.000107368345,0.00021260756,3.3585795e-7,0.9801078,8.579658e-7,0.0006025856,0.0014522069],"study_design_scores_gemma":[0.00053872773,0.0005913638,0.006499415,0.00019742576,0.00010632927,0.00053894863,0.0012390479,0.0000018508854,0.9881413,0.0000016441853,0.0020495094,0.00009443564],"about_ca_topic_score_codex":0.0000019813167,"about_ca_topic_score_gemma":6.081019e-7,"teacher_disagreement_score":0.010439147,"about_ca_system_score_codex":0.000004748832,"about_ca_system_score_gemma":0.000026638661,"threshold_uncertainty_score":0.32152733},"labels":[],"label_agreement":null},{"id":"W2030975404","doi":"10.1016/j.ejmech.2009.11.016","title":"Anti-oxidant and anti-bacterial activities of novel N ′-arylmethylidene-2-(3, 4-dimethyl-5, 5-dioxidopyrazolo[4,3- c ][1,2]benzothiazin-2(4 H )-yl) acetohydrazides","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":103,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Directorate for Biological Sciences; Higher Education Commision, Pakistan; Higher Education Commission, Pakistan","keywords":"Chemistry; Hydrazine (antidepressant); Benzothiazine; Alkylation; Bicyclic molecule; Organic chemistry; Anti oxidant; Medicinal chemistry; Catalysis; Chromatography","score_opus":0.0192646598169379,"score_gpt":0.23831967649802294,"score_spread":0.21905501668108504,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2030975404","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.988954,0.0012613916,0.00012462698,0.0004950779,0.0001588,0.00003673085,0.00003107859,0.000033997705,0.008904309],"genre_scores_gemma":[0.9966426,0.00046595038,0.001088519,0.00010055672,0.0015163474,3.861748e-7,0.0000053672807,0.000032719166,0.00014754428],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9973093,0.00012856125,0.0010978094,0.00038739294,0.0006449971,0.00043192608],"domain_scores_gemma":[0.99745005,0.00043456972,0.0012416245,0.00034891546,0.00017606738,0.00034877125],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0016732039,0.00042596736,0.0010928484,0.00007850554,0.000106670916,0.000051789088,0.00060143473,0.000165471,0.00062349834],"category_scores_gemma":[0.00089182204,0.00030998397,0.00030652774,0.00012884404,0.0004666697,0.00022297246,0.00012389866,0.00079451356,0.000002296414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036790807,0.00046610707,0.00080377643,0.00020538822,0.00013545773,0.00035355767,0.00013745228,0.000005931363,0.98059016,0.000008513298,0.00017322142,0.016752549],"study_design_scores_gemma":[0.0018208309,0.00028298702,0.012544062,0.000681699,0.00014979664,0.0013835304,0.00037214957,0.000013867549,0.9811458,0.00005160082,0.0012218896,0.0003318061],"about_ca_topic_score_codex":0.0000055321602,"about_ca_topic_score_gemma":1.6971136e-7,"teacher_disagreement_score":0.016420742,"about_ca_system_score_codex":0.000053354135,"about_ca_system_score_gemma":0.00009800372,"threshold_uncertainty_score":0.9999352},"labels":[],"label_agreement":null},{"id":"W2032062138","doi":"10.1016/s0223-5234(00)01171-5","title":"Synthesis and in vitro opioid activity profiles of DALDA analogues","year":2000,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":161,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Tetrapeptide; Potency; Agonist; In vitro; μ-opioid receptor; Pharmacology; Stereochemistry; Receptor; Biochemistry; Peptide; Biology","score_opus":0.02040229557476247,"score_gpt":0.2400895393123762,"score_spread":0.21968724373761372,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2032062138","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9887588,0.00010958719,0.0000013747213,0.00010236822,0.00002732967,0.00002486216,0.000007338415,0.000005048811,0.010963286],"genre_scores_gemma":[0.9990931,0.0003858229,0.000055598666,0.00010972425,0.0001904278,2.7740103e-7,2.0658702e-7,0.000013711808,0.00015108913],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988933,0.00022874196,0.00034189475,0.00017149633,0.00020815857,0.0001564119],"domain_scores_gemma":[0.99929273,0.00022393034,0.00024409259,0.00010786668,0.000025818621,0.00010554518],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034487908,0.00011348952,0.00028487,0.000037855378,0.0000289761,0.0000084272015,0.00024455672,0.000017571954,0.00025313304],"category_scores_gemma":[0.000455218,0.000086644366,0.000057869307,0.00010911831,0.00024633142,0.00009103972,0.000039506012,0.00031578643,0.0000064927085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006368962,0.000071909315,0.000098934805,0.00007421128,0.000003621291,0.0005504415,0.000058738457,0.0000041427493,0.970421,7.089193e-7,0.00009808652,0.027981313],"study_design_scores_gemma":[0.00034412308,0.00014855537,0.009324188,0.00016844152,0.000012750638,0.00042122582,0.000040222683,0.000014060182,0.98828554,0.000019461502,0.0011493369,0.00007206798],"about_ca_topic_score_codex":0.0000024330607,"about_ca_topic_score_gemma":7.900341e-8,"teacher_disagreement_score":0.027909245,"about_ca_system_score_codex":0.00001044226,"about_ca_system_score_gemma":0.00002955171,"threshold_uncertainty_score":0.35332546},"labels":[],"label_agreement":null},{"id":"W2035888474","doi":"10.1016/j.ejmech.2010.05.022","title":"Structure–activity relationships of indole compounds derived from combretastatin A4: Synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Centre National de la Recherche Scientifique; Ministère de l'Enseignement Supérieur et de la Recherche; Association pour la Recherche sur le Cancer","keywords":"Chemistry; Carbazole; Indole test; Stereochemistry; Biological activity; Combretastatin; Combinatorial chemistry; Chemical synthesis; In vitro; Organic chemistry; Biochemistry","score_opus":0.03240003023716108,"score_gpt":0.23480718461062716,"score_spread":0.20240715437346607,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2035888474","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99770576,0.0003033096,0.00043917043,0.00013825606,0.00007274136,0.000032443535,0.000098222285,0.000013772654,0.0011963241],"genre_scores_gemma":[0.9975245,0.000071988885,0.0019838745,0.000016176906,0.00036142996,4.2405796e-7,0.000015162969,0.000019388403,0.000007080369],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978586,0.00039012838,0.00074650993,0.00028236778,0.0005086404,0.00021376474],"domain_scores_gemma":[0.9972467,0.00087332324,0.0011996429,0.00025217477,0.00020417504,0.00022402436],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0011138916,0.0002636709,0.00071290694,0.000041381816,0.00011847819,0.00001875315,0.0004157083,0.00018135918,0.0009374483],"category_scores_gemma":[0.0020774275,0.00018513501,0.00022945704,0.00008717175,0.00061498774,0.000093593095,0.0001524128,0.001106673,9.314525e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00054340175,0.0001747061,0.044557564,0.000083741,0.00022775032,0.00012041593,0.00008311732,0.000007467984,0.94339824,0.0000017366842,0.000021641286,0.010780246],"study_design_scores_gemma":[0.00083950226,0.000077654324,0.22573598,0.00023850017,0.00014614793,0.00024545568,0.00034123566,0.0000794957,0.77199507,0.00007681409,0.000075722746,0.00014840563],"about_ca_topic_score_codex":0.000027993914,"about_ca_topic_score_gemma":9.777017e-7,"teacher_disagreement_score":0.18117842,"about_ca_system_score_codex":0.000013661108,"about_ca_system_score_gemma":0.00004626489,"threshold_uncertainty_score":0.9999758},"labels":[],"label_agreement":null},{"id":"W2036442353","doi":"10.1016/j.ejmech.2014.07.018","title":"Towards the development of chromone-based MEK1/2 modulators","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Svenska Forskningsrådet Formas; Cancer Research Society","keywords":"Chromone; Chemistry; Allosteric regulation; Kinase; Structure–activity relationship; In vitro; Lead compound; Protein kinase A; IC50; MAPK/ERK pathway; Drug discovery; Biochemistry; Stereochemistry; Enzyme","score_opus":0.014596002274801767,"score_gpt":0.21871213868301803,"score_spread":0.20411613640821627,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2036442353","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9718763,0.00033693324,0.012423339,0.00019428476,0.00015462462,0.00003082185,0.0000016788496,0.0000030882188,0.014978884],"genre_scores_gemma":[0.9967205,0.00001029684,0.0022349753,0.00013446595,0.000725291,4.8541716e-7,0.000009187546,0.000018893244,0.00014590968],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99876326,0.00013008813,0.00050467096,0.00012442858,0.00033111154,0.0001464276],"domain_scores_gemma":[0.9990401,0.000015960497,0.00039745212,0.00026021618,0.00015620222,0.00013001362],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015411492,0.00013038905,0.00018315422,0.000018570205,0.00005522426,0.000006688359,0.0004257315,0.000038831375,0.00004240418],"category_scores_gemma":[0.00024308772,0.000083561325,0.00010861735,0.000050052877,0.00011205596,0.000002030213,0.00006247025,0.00016918645,0.000003391497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009366528,0.000042646934,0.00022337757,0.000071262,0.000056471083,0.000018142842,0.00013640482,0.000067592366,0.98339117,0.0000049234895,0.0009659985,0.014928361],"study_design_scores_gemma":[0.0008598052,0.00028626557,0.0025899983,0.00009888092,0.00003177091,0.00010584103,0.00010662007,0.00004401691,0.95803386,0.000008755184,0.037733186,0.00010098697],"about_ca_topic_score_codex":3.7317574e-7,"about_ca_topic_score_gemma":2.8985588e-7,"teacher_disagreement_score":0.036767185,"about_ca_system_score_codex":0.000010954356,"about_ca_system_score_gemma":0.00022624973,"threshold_uncertainty_score":0.3407532},"labels":[],"label_agreement":null},{"id":"W2038368414","doi":"10.1016/j.ejmech.2011.02.030","title":"Synthesis of the carbohydrate moiety from the parasite Echinococcus multilocularis and their antigenicity against human sera","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Trisaccharide; Tetrasaccharide; Oligosaccharide; Chemistry; Antigenicity; Stereochemistry; Epitope; Echinococcus multilocularis; Antigen; Biotinylation; Glycoconjugate; Glycoprotein; Parasite hosting; Biochemistry; Molecular biology; Polysaccharide; Biology; Immunology","score_opus":0.020252529381759404,"score_gpt":0.20342175322084416,"score_spread":0.18316922383908477,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2038368414","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9741167,0.0011058388,0.00002202459,0.00018502102,0.00008125246,0.00004136454,0.00008204216,0.000018140288,0.024347644],"genre_scores_gemma":[0.99878246,0.0002809186,0.00008730569,0.000103198705,0.0005836785,0.0000014906949,0.0000048979327,0.000046822915,0.00010925544],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99779016,0.00023342333,0.00093732536,0.00030474464,0.0004369693,0.00029739543],"domain_scores_gemma":[0.997287,0.0004209917,0.0010687375,0.0008157591,0.0001817376,0.00022579561],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011191829,0.00037885003,0.00055631355,0.00001623185,0.0002695516,0.000032765485,0.0012033039,0.00011511482,0.00044896136],"category_scores_gemma":[0.0005386011,0.00020678208,0.00043364963,0.00013874464,0.0006088382,0.00008100254,0.00023533485,0.0009489262,0.000001911383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000099713885,0.000095054645,0.011613499,0.000119411954,0.00033142278,0.00012284843,0.0023157627,0.0000048714805,0.98196024,0.0000011247275,0.00015014899,0.0031859244],"study_design_scores_gemma":[0.00051417557,0.000013942349,0.010886438,0.0007121378,0.00020992791,0.00009833456,0.0017371053,0.000051001778,0.9848749,0.000054496682,0.0006302964,0.00021725414],"about_ca_topic_score_codex":0.00008475769,"about_ca_topic_score_gemma":0.0000036643123,"teacher_disagreement_score":0.02466576,"about_ca_system_score_codex":0.000047946745,"about_ca_system_score_gemma":0.00008082283,"threshold_uncertainty_score":0.84323287},"labels":[],"label_agreement":null},{"id":"W2040877123","doi":"10.1016/j.ejmech.2010.01.025","title":"The bioisosteric similarity of the tetrazole and carboxylate anions: Clues from the topologies of the electrostatic potential and of the electron density","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis of Tetrazole Derivatives","field":"Chemistry","cited_by":79,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"Killam Trusts; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Tetrazole; Chemistry; Carboxylate; Maxima and minima; Lone pair; Similarity (geometry); Topology (electrical circuits); Computational chemistry; Stereochemistry; Chemical physics; Molecule; Combinatorics; Organic chemistry; Image (mathematics); Mathematics; Computer science","score_opus":0.004228172336045973,"score_gpt":0.19566500333887626,"score_spread":0.1914368310028303,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040877123","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99282527,0.002424609,0.0000047973544,0.0037735112,0.00016297543,0.00006500278,0.000025999912,0.0000049624405,0.0007128852],"genre_scores_gemma":[0.99915767,0.00042608587,0.000046481986,0.00008411264,0.00022053113,4.954033e-7,5.309908e-7,0.000017566696,0.000046534882],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99818635,0.00027352123,0.00061767263,0.00015431413,0.0005504962,0.00021767359],"domain_scores_gemma":[0.997109,0.0008749578,0.0011387285,0.0006392774,0.00018424286,0.000053824333],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010223779,0.00019493313,0.00030894432,0.000009781906,0.00029708215,0.000027994689,0.0012692226,0.00006384416,0.00002755378],"category_scores_gemma":[0.002005751,0.00007663092,0.0001824044,0.00012613568,0.0019166196,0.000050380095,0.00037846595,0.0010794736,9.234596e-8],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012086259,0.00003367959,0.020273274,0.000069703485,0.0001330396,0.0000049829364,0.0006684143,0.0000022643935,0.9772248,0.000007766416,0.00021748994,0.0012436908],"study_design_scores_gemma":[0.00035956225,0.00003435915,0.20697825,0.0002127066,0.00016288979,0.00018742026,0.0017962937,0.000018284898,0.78970194,0.00030278976,0.00017956097,0.000065940614],"about_ca_topic_score_codex":0.00004388398,"about_ca_topic_score_gemma":0.000022468017,"teacher_disagreement_score":0.18752289,"about_ca_system_score_codex":0.000018818757,"about_ca_system_score_gemma":0.000121623445,"threshold_uncertainty_score":0.7061865},"labels":[],"label_agreement":null},{"id":"W2040996880","doi":"10.1016/j.ejmech.2013.03.062","title":"In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208)","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Resverlogix (Canada); NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Glycosidic bond; Microsome; Metabolite; Glucuronic acid; Stereochemistry; Glucuronidation; Yield (engineering); UGT2B7; Anomer; S9 fraction; In vivo; In vitro; Chromatography; Enzyme; Biochemistry","score_opus":0.009976254597819654,"score_gpt":0.23023301238385643,"score_spread":0.2202567577860368,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2040996880","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9902712,0.0040724464,0.0012931846,0.00062961126,0.000048631442,0.0001083179,0.00003427726,0.000011720855,0.003530605],"genre_scores_gemma":[0.9914488,0.0005678596,0.007210352,0.00002342424,0.00035767196,0.00000734171,0.000009087491,0.000045357,0.0003301109],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99648374,0.00019661932,0.0021597417,0.00031494015,0.000562982,0.00028195072],"domain_scores_gemma":[0.9960966,0.00053959934,0.0021320374,0.0004990782,0.0005173177,0.00021537623],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0023278696,0.0002751075,0.0007907207,0.00015908024,0.000055261597,0.000025443042,0.0005247015,0.000103249105,0.0012275183],"category_scores_gemma":[0.0011007456,0.00024425058,0.00018960587,0.00028389282,0.00036402477,0.00024525574,0.00009320955,0.00044202618,0.000011246875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012976355,0.00031265058,0.00043428704,0.00053795904,0.000098399614,0.000010182199,0.0003864733,0.000009336341,0.9875248,0.000029855972,0.00014303609,0.010383228],"study_design_scores_gemma":[0.0009692336,0.000034687808,0.0041215033,0.00041995785,0.00021011004,0.00011327347,0.00072061876,0.00025957497,0.9917965,0.0004117767,0.00074695447,0.00019579954],"about_ca_topic_score_codex":0.000026577554,"about_ca_topic_score_gemma":1.9217917e-7,"teacher_disagreement_score":0.010187428,"about_ca_system_score_codex":0.000043280746,"about_ca_system_score_gemma":0.00009173286,"threshold_uncertainty_score":0.99968547},"labels":[],"label_agreement":null},{"id":"W2042936254","doi":"10.1016/j.ejmech.2014.03.057","title":"Cytotoxic properties of d-gluco-, d-galacto- and d-manno-configured 2-amino-2-deoxy-glycerolipids against epithelial cancer cell lines and BT-474 breast cancer stem cells","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DU145; Chemistry; Cancer; Cancer cell; Cytotoxicity; Cancer stem cell; Biochemistry; Stereochemistry; Aglycone; Cytotoxic T cell; Cancer research; Glycoside; LNCaP; In vitro; Biology","score_opus":0.009421876822019433,"score_gpt":0.20942608105268765,"score_spread":0.20000420423066823,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2042936254","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9895365,0.008678506,0.00005881237,0.00021438448,0.00029300398,0.00006836434,0.00006658843,0.0000049079235,0.0010789187],"genre_scores_gemma":[0.98980165,0.006866002,0.000033549964,0.0002487285,0.0020904886,0.0000025083639,0.00000525965,0.000038321767,0.00091348955],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984426,0.00014553494,0.00059736246,0.00029213977,0.00027153557,0.00025082787],"domain_scores_gemma":[0.99860144,0.0000135541095,0.000528042,0.00022242375,0.00040186956,0.00023270023],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00053808425,0.00027417293,0.00039417986,0.00003210845,0.00006156164,0.000027431004,0.0002990215,0.00009670381,0.000051805335],"category_scores_gemma":[0.000029442357,0.00020649651,0.00010461105,0.000040701892,0.0002804174,0.000016487174,0.00010820616,0.00025612654,0.0000016353986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000542704,0.000051918174,0.001084056,0.00039258137,0.000105601895,0.000019301538,0.00022163794,0.000035869623,0.990793,2.8861447e-7,0.0012334986,0.0055195345],"study_design_scores_gemma":[0.001611689,0.00039821453,0.0017770138,0.0006462037,0.000107724496,0.00016312097,0.00043682885,0.00004854499,0.98977,0.0000010117229,0.0048142527,0.00022541109],"about_ca_topic_score_codex":0.000034905603,"about_ca_topic_score_gemma":0.000010559752,"teacher_disagreement_score":0.005294123,"about_ca_system_score_codex":0.000021328344,"about_ca_system_score_gemma":0.00012553977,"threshold_uncertainty_score":0.8420683},"labels":[],"label_agreement":null},{"id":"W2045490219","doi":"10.1016/j.ejmech.2011.02.032","title":"Synthesis, in vitro screening and in vivo evaluation of cyclic RGD analogs cyclized through oxorhenium and oxotechnetium coordination","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer","keywords":"Tripeptide; Chemistry; In vivo; In vitro; Integrin; Chelation; Stereochemistry; Cyclic peptide; Dipeptide; Biochemistry; Amino acid; Peptide; Receptor; Organic chemistry","score_opus":0.06961232690302326,"score_gpt":0.3184324359806051,"score_spread":0.24882010907758184,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2045490219","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9867433,0.0015542444,0.00044425656,0.00062513555,0.00001585735,0.00011970062,0.000003419502,0.000006505412,0.010487594],"genre_scores_gemma":[0.9974133,0.00026545086,0.0020997215,0.000056514647,0.00011913366,0.0000037713637,0.0000026906077,0.000014987352,0.000024481718],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.998427,0.0001498809,0.0006623748,0.00017530101,0.0004359586,0.00014948168],"domain_scores_gemma":[0.99908173,0.00012587511,0.0003461489,0.00013526317,0.0001662252,0.00014477778],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0022644517,0.0001330495,0.00035993123,0.000074632466,0.000024690331,0.0000050811636,0.000103919985,0.000058706755,0.00012635108],"category_scores_gemma":[0.00070354395,0.0001170814,0.000047388574,0.00021208488,0.00020166281,0.00009076556,0.000030043851,0.0004475168,3.2653008e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00075784355,0.00013221463,0.0026422604,0.00020653433,0.00002712643,0.00009932157,0.00036199574,0.0000051293864,0.9888326,0.0000029763173,0.00004631699,0.006885679],"study_design_scores_gemma":[0.0039174818,0.00006369035,0.03024376,0.0007336885,0.000296265,0.00070656656,0.0005916656,0.00072440406,0.9623051,0.000092740986,0.00022348113,0.00010111979],"about_ca_topic_score_codex":0.000007287273,"about_ca_topic_score_gemma":2.7835208e-7,"teacher_disagreement_score":0.0276015,"about_ca_system_score_codex":0.000051567044,"about_ca_system_score_gemma":0.00005711586,"threshold_uncertainty_score":0.47744408},"labels":[],"label_agreement":null},{"id":"W2045838145","doi":"10.1016/j.ejmech.2014.12.037","title":"Design, synthesis and bioevaluation of novel 6-(4-Hydroxypiperidino)naphthalen-2-ol-based potential Selective Estrogen Receptor Modulators for breast cancer","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto Western Hospital; Dalhousie University; Acadia University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society","keywords":"Chemistry; Estrogen receptor; Ether; In vivo; Selective estrogen receptor modulator; In vitro; Pharmacology; Aryl; Membrane permeability; Estrogen; Stereochemistry; Breast cancer; Membrane; Cancer; Biochemistry; Endocrinology; Internal medicine; Organic chemistry","score_opus":0.010181424091834307,"score_gpt":0.2399333937363991,"score_spread":0.2297519696445648,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2045838145","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9476294,0.0012712582,0.05039649,0.0002813037,0.00014179997,0.00013803325,0.000040174957,0.000004863518,0.00009670725],"genre_scores_gemma":[0.9958618,0.00014057496,0.0031928513,0.00005202728,0.00067117944,0.0000052365062,0.000011637591,0.000038418584,0.000026228596],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99875724,0.00019419332,0.0003943712,0.00021649348,0.00025272687,0.0001849814],"domain_scores_gemma":[0.9988089,0.000063419415,0.00047888685,0.00014147545,0.0003412287,0.00016609603],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012499933,0.00018500647,0.0002625308,0.00004273098,0.00006365882,0.000009948876,0.000180029,0.00009942977,0.000019029669],"category_scores_gemma":[0.00029030014,0.00014879393,0.00014247901,0.00007048283,0.00014380558,0.000008364928,0.00002726105,0.00016581576,4.2342657e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009542421,0.000094983305,0.00025160683,0.000102119324,0.00020110329,0.0000043806976,0.00002582499,0.0018422189,0.9886173,0.0000010665767,0.00038334762,0.0075218026],"study_design_scores_gemma":[0.0021629527,0.0007100235,0.00074335677,0.0002379645,0.00024544602,0.00036035388,0.000039389204,0.003645643,0.9914395,0.0000030476822,0.00025524758,0.00015707141],"about_ca_topic_score_codex":0.0000020422044,"about_ca_topic_score_gemma":2.3778142e-8,"teacher_disagreement_score":0.048232477,"about_ca_system_score_codex":0.000024775298,"about_ca_system_score_gemma":0.00015611842,"threshold_uncertainty_score":0.606764},"labels":[],"label_agreement":null},{"id":"W2046569740","doi":"10.1016/j.ejmech.2009.06.038","title":"Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":57,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Directorate for Biological Sciences; University of Karachi","keywords":"Chemistry; Benzaldehyde; Bromide; Imidazole; Catalysis; Condensation; Stereochemistry; Organic chemistry; Medicinal chemistry","score_opus":0.017729297563011594,"score_gpt":0.23124649473869688,"score_spread":0.2135171971756853,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2046569740","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9785724,0.00089966186,0.000119742785,0.000579053,0.00013669401,0.000036922775,0.000036438752,0.000036190864,0.019582842],"genre_scores_gemma":[0.996681,0.000557893,0.00047508703,0.000090741625,0.0019557234,3.096774e-7,0.000004626776,0.00003321267,0.0002014124],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9973843,0.00012345979,0.000967868,0.00039028798,0.0006976686,0.0004363927],"domain_scores_gemma":[0.9978113,0.00032132692,0.0010644987,0.00030969366,0.00017578111,0.00031740236],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001232291,0.00042358466,0.0010090977,0.00006106623,0.0001255872,0.000054241074,0.00058654865,0.00015939142,0.0004552143],"category_scores_gemma":[0.0006039714,0.0003052223,0.00027842948,0.00013160848,0.0004261939,0.00021882709,0.00012337831,0.0009088068,0.0000024668132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023248333,0.00065917586,0.0053532547,0.00026927862,0.000115304974,0.0006311552,0.00017214818,0.000006364601,0.9777775,0.0000071212758,0.0002834625,0.014492755],"study_design_scores_gemma":[0.0019975875,0.00025978382,0.04873984,0.000825644,0.00016555993,0.0030226335,0.0008653789,0.000037948317,0.9421765,0.00001658955,0.0015098109,0.0003827016],"about_ca_topic_score_codex":0.0000033890328,"about_ca_topic_score_gemma":1.5786739e-7,"teacher_disagreement_score":0.043386586,"about_ca_system_score_codex":0.000047795696,"about_ca_system_score_gemma":0.000081429695,"threshold_uncertainty_score":0.99994},"labels":[],"label_agreement":null},{"id":"W2046881199","doi":"10.1016/j.ejmech.2011.12.017","title":"Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Ferrocene Chemistry and Applications","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Chemistry; Estrogen receptor; Carboplatin; Oxaliplatin; Cisplatin; Moiety; Estrogen; In vivo; Stereochemistry; Internal medicine; Endocrinology; Cancer; Biology; Chemotherapy; Breast cancer","score_opus":0.040710922360218026,"score_gpt":0.25570808158282254,"score_spread":0.2149971592226045,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2046881199","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99367213,0.00033380193,0.00096260663,0.00030233266,0.000037542304,0.00011543793,0.00033322835,0.000030718125,0.0042121885],"genre_scores_gemma":[0.98315436,0.00004572162,0.016078968,0.0000402169,0.0005140557,0.0000064481624,0.000026050024,0.000048008777,0.00008618336],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9977548,0.000069355614,0.00085020973,0.00045774312,0.0005114296,0.00035647856],"domain_scores_gemma":[0.99781436,0.00015810748,0.0007177899,0.00034285826,0.00026217138,0.0007047203],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005429815,0.00040896572,0.000722596,0.000057588768,0.00021629159,0.00003191312,0.00047748777,0.0001032121,0.0006561433],"category_scores_gemma":[0.00045826528,0.00038488,0.00011617277,0.00015677705,0.00027707918,0.0001083451,0.00023669457,0.00055886706,0.0000029507696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006174762,0.00033836023,0.0012615948,0.0002714302,0.00018724217,0.00011110062,0.0011752755,0.000043241187,0.99408144,0.00001774808,0.00028454076,0.0016105622],"study_design_scores_gemma":[0.0011638202,0.00022265993,0.0073612016,0.00037595295,0.00015621903,0.0008920256,0.00083824084,0.0001117889,0.98805314,0.000012323783,0.00046850022,0.00034410125],"about_ca_topic_score_codex":0.000026249623,"about_ca_topic_score_gemma":0.0000010766747,"teacher_disagreement_score":0.01511636,"about_ca_system_score_codex":0.00006175348,"about_ca_system_score_gemma":0.00011999979,"threshold_uncertainty_score":0.9998603},"labels":[],"label_agreement":null},{"id":"W2046979377","doi":"10.1016/s0223-5234(01)01262-4","title":"Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group","year":2001,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Medical Research Council Canada","keywords":"Androstane; Chemistry; Steroid; Pregnane; Stereochemistry; Pregnenolone; Danazol; Internal medicine; Biochemistry; Hormone","score_opus":0.007988836165922521,"score_gpt":0.21783025015783777,"score_spread":0.20984141399191525,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2046979377","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9929312,0.005763131,0.00022331534,0.00008104057,0.000043603388,0.00004261502,0.000005278914,0.000004131538,0.000905676],"genre_scores_gemma":[0.9982782,0.000957214,0.00024661416,0.0000251181,0.00042456895,5.505368e-7,0.0000042749193,0.000024800785,0.000038677466],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99889594,0.00017779219,0.00034664955,0.00020060124,0.00019666918,0.00018237389],"domain_scores_gemma":[0.999158,0.00006574711,0.00038703057,0.00012431954,0.00006836434,0.00019649597],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007749785,0.00017428063,0.00025799646,0.000037929603,0.00006861456,0.00001724226,0.00012001371,0.00007173395,0.0000069943226],"category_scores_gemma":[0.00027422208,0.00014662887,0.00007119822,0.0000539103,0.00023387888,0.000015759868,0.00013521135,0.0003106951,3.6475168e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038093477,0.000057269855,0.003501617,0.00013432755,0.00009821391,0.00031815274,0.00012614056,0.0000028783393,0.9815963,5.8608555e-7,0.00006702478,0.013716568],"study_design_scores_gemma":[0.0011084405,0.00049933535,0.0064600976,0.00047462826,0.00008143105,0.001937042,0.0003497413,0.0000135823575,0.98858243,0.0000026186517,0.00034724383,0.00014342107],"about_ca_topic_score_codex":0.0000025091451,"about_ca_topic_score_gemma":3.0862827e-7,"teacher_disagreement_score":0.013573146,"about_ca_system_score_codex":0.000010398902,"about_ca_system_score_gemma":0.000030559517,"threshold_uncertainty_score":0.59793514},"labels":[],"label_agreement":null},{"id":"W2047133125","doi":"10.1016/j.ejmech.2011.06.012","title":"New azole antifungal agents with novel modes of action: Synthesis and biological studies of new tridentate ligands based on pyrazole and triazole","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pyrazole; Azole; Yeast; Mechanism of action; Triazole; Saccharomyces cerevisiae; Cell cycle; DNA; Biochemistry; Combinatorial chemistry; Stereochemistry; Antifungal; Cell; In vitro; Microbiology; Biology","score_opus":0.16523659559781892,"score_gpt":0.32783378584089784,"score_spread":0.16259719024307892,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2047133125","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9957015,0.0013497078,0.0006803118,0.00018243254,0.00003640827,0.00006431536,0.000006077832,0.000006025805,0.0019732234],"genre_scores_gemma":[0.9973859,0.0008302832,0.001237762,0.00006812876,0.00020085931,2.1018359e-7,9.384348e-7,0.000013811252,0.00026208046],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99868625,0.000040556082,0.00056563085,0.00018006029,0.00038878788,0.00013871733],"domain_scores_gemma":[0.9987273,0.00015739581,0.00048383785,0.00016201615,0.0001785491,0.00029089654],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008212206,0.00016928825,0.0006127466,0.000058166082,0.000036413287,0.000004399995,0.000101419915,0.00003964658,0.00013104382],"category_scores_gemma":[0.0005111767,0.00010451722,0.000089472735,0.000100901016,0.00030885354,0.000060049446,0.000028855586,0.00026204158,4.1640553e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.018510623,0.00044348606,0.11035536,0.0008829178,0.00047322526,0.0004765276,0.0011360933,0.000008058496,0.8517677,0.0000034956179,0.0018428146,0.0140996715],"study_design_scores_gemma":[0.0053598857,0.0018681374,0.2306315,0.0018545862,0.0003819931,0.0002611802,0.0030026608,0.000048578306,0.7564008,0.000009485509,0.00007248209,0.00010866998],"about_ca_topic_score_codex":0.000008205872,"about_ca_topic_score_gemma":7.1461477e-7,"teacher_disagreement_score":0.12027614,"about_ca_system_score_codex":0.000021976097,"about_ca_system_score_gemma":0.00017388846,"threshold_uncertainty_score":0.42620885},"labels":[],"label_agreement":null},{"id":"W2047561743","doi":"10.1016/j.ejmech.2003.09.011","title":"Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds","year":2004,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Anticonvulsant; Stereochemistry; Cytotoxic T cell; Cytotoxicity; Pharmacology; In vitro; Biochemistry","score_opus":0.013708003453952095,"score_gpt":0.21625246136939452,"score_spread":0.20254445791544243,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2047561743","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9703832,0.0018052678,0.000008484258,0.0004994487,0.000039754,0.00001363998,0.0000024464098,0.000018424136,0.02722929],"genre_scores_gemma":[0.9988602,0.00044084707,0.00015516787,0.000072266455,0.00026026738,1.9043696e-7,0.0000024500061,0.0000165588,0.00019208035],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988757,0.00004373332,0.0004560965,0.00019483766,0.00024022078,0.00018946163],"domain_scores_gemma":[0.9990915,0.00012949553,0.00033011514,0.00013208223,0.0000582102,0.00025857167],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006398326,0.00018248812,0.00033196475,0.00002041862,0.00008825984,0.000028763772,0.00018167568,0.000059385242,0.0003986217],"category_scores_gemma":[0.000280449,0.00012474973,0.00007460355,0.00005165505,0.00025199522,0.0000692128,0.00006649161,0.00049564877,0.000003920026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014411597,0.00011458634,0.0032262597,0.00012528854,0.00006410655,0.0014254423,0.00009584245,0.0000012140235,0.989949,0.00000781283,0.000037011534,0.00480935],"study_design_scores_gemma":[0.0024279756,0.00020795224,0.024716422,0.00085021445,0.000118633805,0.009038091,0.0007069903,0.000009097942,0.9603881,0.00031762134,0.00096144155,0.00025742373],"about_ca_topic_score_codex":0.0000023711034,"about_ca_topic_score_gemma":1.12590136e-7,"teacher_disagreement_score":0.029560834,"about_ca_system_score_codex":0.000030251365,"about_ca_system_score_gemma":0.00003319034,"threshold_uncertainty_score":0.5087146},"labels":[],"label_agreement":null},{"id":"W2048883883","doi":"10.1016/j.ejmech.2014.08.033","title":"Recent developments in biological activities of chalcones: A mini review","year":2014,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":695,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Inyuvesi Yakwazulu-Natali; Public Health Agency of Canada","keywords":"Chemistry; Biochemical engineering","score_opus":0.106468116441031,"score_gpt":0.3246705865471237,"score_spread":0.21820247010609273,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2048883883","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0013336709,0.97542995,0.0000025954846,0.00006817308,0.00009419688,0.000073336705,0.00001708897,0.000009740375,0.022971237],"genre_scores_gemma":[0.0013450882,0.99760044,0.00012100556,0.00007398087,0.0006549169,0.0000045017136,0.000025447538,0.00003479609,0.00013980122],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99598104,0.0005602821,0.0022691884,0.00035850122,0.00050203485,0.00032894526],"domain_scores_gemma":[0.99566257,0.00072591344,0.002954721,0.00032099985,0.00012438881,0.00021141641],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0030589665,0.00051975163,0.0034434504,0.00006589789,0.000025662537,0.000009068765,0.00092385267,0.00024461467,0.0015269171],"category_scores_gemma":[0.002163377,0.00030080104,0.000658915,0.00020360952,0.00023636776,0.00003685023,0.0001823022,0.0012126443,0.00001211892],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003379477,0.0001825572,0.000030418541,0.052420326,0.00014417055,0.0003198233,0.000016480695,1.3345257e-8,0.0008698599,4.4520763e-7,0.0005186589,0.9454635],"study_design_scores_gemma":[0.0002713597,0.00006866792,0.000014734792,0.16075093,0.0002485314,0.00071947154,0.000047969756,4.5823533e-8,0.0013834842,0.0000017706603,0.83623713,0.0002558957],"about_ca_topic_score_codex":5.5331395e-7,"about_ca_topic_score_gemma":9.712177e-8,"teacher_disagreement_score":0.94520754,"about_ca_system_score_codex":0.00015910382,"about_ca_system_score_gemma":0.00027087363,"threshold_uncertainty_score":0.9999444},"labels":[],"label_agreement":null},{"id":"W2049660674","doi":"10.1016/j.ejmech.2013.10.053","title":"Identification of sulfonic acids as efficient ecto-5′-nucleotidase inhibitors","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Jürgen Manchot Stiftung","keywords":"5'-nucleotidase; Chemistry; Sulfonic acid; Enzyme; Biochemistry; Nucleotidase; Cancer cell; Cancer; Biology; Organic chemistry","score_opus":0.004795318666708214,"score_gpt":0.2164386656465953,"score_spread":0.2116433469798871,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2049660674","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9939338,0.002242697,0.0006596831,0.00021978427,0.00015243667,0.000050507806,0.000001884824,0.000004030892,0.0027352013],"genre_scores_gemma":[0.9981424,0.00008395683,0.000080819394,0.00007385253,0.0010316089,6.8616146e-7,0.00000984109,0.000023176955,0.0005536526],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985932,0.000093181756,0.0006858493,0.00015663383,0.00031281955,0.00015832021],"domain_scores_gemma":[0.9986833,0.000016543137,0.0005950149,0.00022567145,0.0003232864,0.00015618656],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00073776423,0.00013394833,0.00017606169,0.000037029582,0.000038493563,0.000016040234,0.0002950048,0.000045521858,0.00022518274],"category_scores_gemma":[0.00030483262,0.00011126582,0.00013409545,0.00009061894,0.00011358922,0.0000058032506,0.00006686901,0.00019432702,0.000030995812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000054895867,0.00006662795,0.00037748565,0.000053306027,0.00004630198,0.00004710603,0.00007985383,0.00032625385,0.990758,0.0000017838883,0.0073430575,0.00084531796],"study_design_scores_gemma":[0.0007852836,0.000286136,0.0017226103,0.00012853339,0.00004763161,0.0004126851,0.00035224116,0.00004988035,0.99341106,0.000009488013,0.0026749787,0.00011949138],"about_ca_topic_score_codex":0.00000318424,"about_ca_topic_score_gemma":2.0262956e-8,"teacher_disagreement_score":0.004668079,"about_ca_system_score_codex":0.000013935307,"about_ca_system_score_gemma":0.00008780993,"threshold_uncertainty_score":0.45372882},"labels":[],"label_agreement":null},{"id":"W2051075639","doi":"10.1016/j.ejmech.2010.07.051","title":"Synthesis of the steroidal glycoside (25R)-3β,16β-diacetoxy-12,22-dioxo-5α-cholestan-26-yl β-d-glucopyranoside and its anti-cancer properties on cervicouterine HeLa, CaSki, and ViBo cells","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"HeLa; Chemistry; Apoptosis; Cytotoxic T cell; Cancer cell; DNA fragmentation; Programmed cell death; Fragmentation (computing); Glycoside; Cytotoxicity; Cell growth; Cell culture; Biochemistry; Cell; Molecular biology; Cancer; Stereochemistry; In vitro; Biology","score_opus":0.008637328271248471,"score_gpt":0.20797368753011428,"score_spread":0.1993363592588658,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2051075639","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9922164,0.004756691,0.000005196883,0.0018530424,0.00038306403,0.00011020524,0.00003891375,0.000006640823,0.00062986376],"genre_scores_gemma":[0.9953915,0.0022318724,0.000086526605,0.00026079547,0.0012401207,0.000001709009,0.0000012674263,0.00005461748,0.00073162524],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99826765,0.00017138447,0.0005352679,0.0003479624,0.00039851564,0.000279216],"domain_scores_gemma":[0.9986655,0.000058704154,0.0005151822,0.00037287417,0.00018625848,0.00020144074],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00072253175,0.0003106388,0.00042217827,0.00003739071,0.00012424312,0.00003995984,0.00042126913,0.0001153897,0.000069268535],"category_scores_gemma":[0.00034623558,0.00019707435,0.0001458097,0.000060080227,0.00030936545,0.000019360537,0.00020005647,0.00061647815,0.0000014716909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042498487,0.000057560086,0.0004930514,0.00027112177,0.00012333525,0.000040740775,0.0001163611,0.0000052204505,0.988416,7.6228514e-7,0.00062659755,0.009424265],"study_design_scores_gemma":[0.00067004445,0.00023048752,0.0026923795,0.0004185637,0.00011343421,0.0004251549,0.00024342095,0.000009082484,0.9889196,0.0000030022636,0.0060524885,0.00022231156],"about_ca_topic_score_codex":0.000008624513,"about_ca_topic_score_gemma":0.000005708102,"teacher_disagreement_score":0.009201953,"about_ca_system_score_codex":0.000015766285,"about_ca_system_score_gemma":0.00008310943,"threshold_uncertainty_score":0.8036459},"labels":[],"label_agreement":null},{"id":"W2054928097","doi":"10.1016/j.ejmech.2009.11.051","title":"Synthesis and antioxidant properties of enone core based dendrimers with carbazole as surface group","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Dendrimers and Hyperbranched Polymers","field":"Materials Science","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Indian Institute of Technology Madras; Council of Scientific and Industrial Research, India","keywords":"Chemistry; Carbazole; Enone; Dendrimer; Group (periodic table); Core (optical fiber); Stereochemistry; Organic chemistry","score_opus":0.013957900827676081,"score_gpt":0.20820698555225778,"score_spread":0.1942490847245817,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2054928097","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9906067,0.0038136926,0.00007273451,0.00027555603,0.00007265663,0.000037133657,0.000003508886,0.000010710379,0.0051072766],"genre_scores_gemma":[0.9986674,0.00006172478,0.00089617376,0.00011938896,0.00012842978,1.3659312e-7,3.9644223e-7,0.000018282202,0.000108031534],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986407,0.0000889807,0.00041616717,0.00016023834,0.0004887908,0.00020508011],"domain_scores_gemma":[0.9990514,0.000042415406,0.00042524995,0.00016233731,0.000112868445,0.00020574656],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00081444375,0.00016664516,0.00036084457,0.00003156124,0.000059119222,0.000023670045,0.00025517202,0.000025462079,0.00018487523],"category_scores_gemma":[0.000093340925,0.00011081203,0.00005747626,0.000084387015,0.00031071494,0.000099261015,0.000018431576,0.00018694067,0.0000050349913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048688866,0.00006828661,0.00028918966,0.00010456947,0.000022505825,0.00043980466,0.00030427717,0.000039749062,0.9971363,0.0000027471526,0.00011258904,0.0009930753],"study_design_scores_gemma":[0.00088604365,0.00048750703,0.0015220306,0.00086533924,0.00013171766,0.0007842555,0.0005982992,0.000020323174,0.99423724,0.0000016447842,0.0003288574,0.0001367518],"about_ca_topic_score_codex":0.000012369625,"about_ca_topic_score_gemma":4.0797894e-7,"teacher_disagreement_score":0.008060705,"about_ca_system_score_codex":0.000018604962,"about_ca_system_score_gemma":0.00010441654,"threshold_uncertainty_score":0.45187834},"labels":[],"label_agreement":null},{"id":"W2056285176","doi":"10.1016/j.ejmech.2013.08.011","title":"New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure–activity relationships and biological evaluation","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Canadian Institutes of Health Research","keywords":"DU145; LNCaP; Chemistry; Prostate cancer; Cancer research; Cisplatin; Cancer cell; Cancer; Stereochemistry; Biochemistry; Internal medicine; Chemotherapy; Biology; Medicine","score_opus":0.0747840343293904,"score_gpt":0.2757564175845183,"score_spread":0.2009723832551279,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056285176","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99212676,0.003425487,0.00037674778,0.00201488,0.000061540246,0.00038879513,0.000030692703,0.000017775958,0.0015573147],"genre_scores_gemma":[0.9952709,0.00031238352,0.003510089,0.00015771661,0.00029404127,0.0000036114322,0.000044920507,0.000029888202,0.0003764202],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9973716,0.0007969345,0.00074349943,0.00023878303,0.0006387327,0.00021045691],"domain_scores_gemma":[0.99764895,0.00042809348,0.00084973127,0.00019883492,0.00041125395,0.00046314907],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0011548504,0.00026108677,0.0006122669,0.0000653424,0.00018413001,0.00002900829,0.00014908615,0.00007701153,0.0028350349],"category_scores_gemma":[0.0020121979,0.00018067664,0.00009262406,0.00011309964,0.00021668305,0.00014143247,0.000084876105,0.00046392754,0.000009093404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011157413,0.00005155856,0.0016439628,0.00012688339,0.00014761378,0.000026997019,0.0004261358,0.000050391965,0.96431845,0.0000023798345,0.006104263,0.0259856],"study_design_scores_gemma":[0.0031659899,0.00178843,0.0851235,0.0021753877,0.0005318006,0.0012129218,0.00033465002,0.00065660354,0.90375113,0.00024133016,0.0007299458,0.00028828575],"about_ca_topic_score_codex":0.000079177975,"about_ca_topic_score_gemma":0.0000022865122,"teacher_disagreement_score":0.08347954,"about_ca_system_score_codex":0.00012207212,"about_ca_system_score_gemma":0.00036727716,"threshold_uncertainty_score":0.9980765},"labels":[],"label_agreement":null},{"id":"W2056342283","doi":"10.1016/j.ejmech.2009.11.006","title":"Structure–activity relationships and mechanism of action of antitumor bis 8-hydroxyquinoline substituted benzylamines","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis of Indole Derivatives","field":"Chemistry","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Centre National de la Recherche Scientifique; Ligue Contre le Cancer","keywords":"Chemistry; Mechanism of action; Quinone methide; Adduct; Biochemistry; Structure–activity relationship; Stereochemistry; Biological activity; DNA; Cancer cell; Cancer; In vitro; Quinone; Organic chemistry; Biology","score_opus":0.0302971202330715,"score_gpt":0.24948721484902214,"score_spread":0.21919009461595065,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2056342283","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952546,0.0005070247,0.00053853926,0.00024607417,0.000063420506,0.000023880038,0.00001881549,0.0000138560645,0.003333809],"genre_scores_gemma":[0.99849063,0.00012255194,0.00089822896,0.0000095230625,0.00040137244,9.999799e-8,0.000005368861,0.000018583776,0.000053625645],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984142,0.000098807366,0.00070880284,0.0001656582,0.00046358758,0.00014890808],"domain_scores_gemma":[0.99785095,0.00018721003,0.0013129581,0.00023504731,0.00028112304,0.00013271619],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00061650627,0.00019557922,0.00045071257,0.0000875369,0.00005924169,0.000009258005,0.0002671387,0.00007140267,0.00018695067],"category_scores_gemma":[0.0011846937,0.00016936597,0.00010023811,0.00013567868,0.00019314003,0.00017758965,0.000029830824,0.000526372,3.525466e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001802059,0.000089856076,0.0010553722,0.0002706272,0.00007202524,0.000088398265,0.00018859761,0.000015399399,0.994365,0.000039309863,0.000040056355,0.003595203],"study_design_scores_gemma":[0.00097211514,0.00008794657,0.020173224,0.0006343225,0.000098663666,0.000593625,0.00043290737,0.000053906715,0.9766019,0.00016621772,0.00005886342,0.00012633471],"about_ca_topic_score_codex":0.0000023367636,"about_ca_topic_score_gemma":3.864558e-7,"teacher_disagreement_score":0.01911785,"about_ca_system_score_codex":0.00003408908,"about_ca_system_score_gemma":0.00007441946,"threshold_uncertainty_score":0.6906544},"labels":[],"label_agreement":null},{"id":"W2063524632","doi":"10.1016/j.ejmech.2009.12.076","title":"Stilbene analogs as inducers of apolipoprotein-I transcription","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada); Resverlogix (Canada)","funders":"","keywords":"Resveratrol; Chemistry; Inducer; Apolipoprotein B; Biochemistry; Transcription (linguistics); Pharmacology; Stereochemistry; Gene; Cholesterol; Biology","score_opus":0.007419874815015594,"score_gpt":0.23724708071735326,"score_spread":0.22982720590233766,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2063524632","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9864819,0.0006244156,0.00070202886,0.00026689397,0.0002068808,0.00003365446,0.0000051678257,0.0000023846621,0.011676681],"genre_scores_gemma":[0.9978302,0.00017620073,0.00042960077,0.000088117646,0.0009729769,6.613089e-7,0.000012258462,0.00001771985,0.0004722818],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990754,0.00005023363,0.00039229522,0.00012554554,0.00023743178,0.00011905965],"domain_scores_gemma":[0.9990532,0.0000048912143,0.00034254498,0.00023600184,0.0002227188,0.00014067606],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00061461714,0.0001042589,0.0001458754,0.000029894492,0.000031626547,0.0000073643264,0.00028583145,0.00005810029,0.00018875174],"category_scores_gemma":[0.00014018973,0.00008812733,0.00011253049,0.00006751748,0.000142179,0.0000050989124,0.000018391373,0.0003279956,0.0000035215758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011254189,0.00004478208,0.00016840835,0.00002994223,0.000042161253,0.000020013931,0.00006073705,0.000009037764,0.9878984,0.000011830361,0.0008242902,0.010777858],"study_design_scores_gemma":[0.0008008657,0.0003098618,0.002698544,0.000051302035,0.000044721397,0.0003665094,0.00020200567,0.0000028741993,0.96735567,0.000025027563,0.028048575,0.00009402264],"about_ca_topic_score_codex":0.0000070754822,"about_ca_topic_score_gemma":0.0000012394314,"teacher_disagreement_score":0.027224284,"about_ca_system_score_codex":0.0000081132175,"about_ca_system_score_gemma":0.00013548501,"threshold_uncertainty_score":0.35937282},"labels":[],"label_agreement":null},{"id":"W2066528340","doi":"10.1016/j.ejmech.2012.12.043","title":"Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: A P3 and N-cap optimization study","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Biomedical Research Council; Public Health Agency of Canada","keywords":"Peptidomimetic; Dipeptide; Chemistry; NS3; Agmatine; Serine protease; IC50; Protease; Protease inhibitor (pharmacology); Active site; West Nile virus; Enzyme inhibitor; Stereochemistry; Peptide; Biochemistry; Enzyme; Virology; Virus; In vitro; Biology","score_opus":0.008424437054208977,"score_gpt":0.22484065028393738,"score_spread":0.2164162132297284,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2066528340","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9882475,0.0025004628,0.0012109311,0.0027622932,0.0001356921,0.0007287545,0.000007823807,0.000025088235,0.0043814224],"genre_scores_gemma":[0.9962835,0.00010791234,0.0004970692,0.00077822764,0.0017467858,0.000014085201,0.000010048751,0.000044115044,0.0005183024],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.998012,0.00013367081,0.0007399969,0.00021715485,0.0006527744,0.00024440556],"domain_scores_gemma":[0.99826705,0.000070556605,0.00053427,0.0003109978,0.0003626702,0.00045447357],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009343858,0.00023652974,0.00038471946,0.000045496887,0.00013041025,0.000068006986,0.00022812428,0.000031846463,0.0005481496],"category_scores_gemma":[0.0005412095,0.00014305493,0.00012341319,0.0001423112,0.00013935856,0.00012709732,0.00007842572,0.0005370767,0.000018059285],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002192789,0.0038245572,0.013904539,0.0009539106,0.0009670717,0.002748528,0.0030656573,0.0016909116,0.8668359,0.0000030624149,0.030317582,0.07349549],"study_design_scores_gemma":[0.13933207,0.01909453,0.5877527,0.014743715,0.009332138,0.01651834,0.080856055,0.043820173,0.047017336,0.0000335155,0.037907224,0.0035922118],"about_ca_topic_score_codex":0.000020827894,"about_ca_topic_score_gemma":7.295082e-7,"teacher_disagreement_score":0.81981856,"about_ca_system_score_codex":0.000042384032,"about_ca_system_score_gemma":0.00011652305,"threshold_uncertainty_score":0.60018533},"labels":[],"label_agreement":null},{"id":"W2068027134","doi":"10.1016/j.ejmech.2013.04.027","title":"Synthesis and preliminary in vitro biological evaluation of 7α-testosterone–chlorambucil hybrid designed for the treatment of prostate cancer","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Chlorambucil; LNCaP; Prostate cancer; Chemistry; Prostate; In vitro; Testosterone (patch); Cancer; Cancer research; Pharmacology; Internal medicine; Biochemistry; Chemotherapy; Medicine","score_opus":0.04108592914816396,"score_gpt":0.2755062072691631,"score_spread":0.23442027812099914,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2068027134","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9886457,0.010485351,0.00010635227,0.00023787294,0.000032674467,0.00032430934,0.000022396052,0.0000010307806,0.0001443245],"genre_scores_gemma":[0.9977898,0.0015940563,0.0003173174,0.000021962438,0.00018277121,0.00004375585,0.00000777313,0.00001114005,0.00003142881],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989986,0.00019343344,0.0003816542,0.00012448983,0.00018472319,0.000117093696],"domain_scores_gemma":[0.9990686,0.00011783377,0.00035645295,0.00012686185,0.00027068617,0.000059526057],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011546398,0.000110429784,0.0002038088,0.000018235625,0.000024358349,0.000005384115,0.00012873592,0.000029513525,0.000038693495],"category_scores_gemma":[0.0003406699,0.00006571396,0.00007160508,0.000029251189,0.00014258389,0.000004282545,0.0000222365,0.00005685294,2.6082424e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00096767733,0.000104006525,0.00067737047,0.0000627693,0.00005981102,0.00000487495,0.00016119478,0.000029540906,0.89513606,8.9328815e-8,0.000078055826,0.10271857],"study_design_scores_gemma":[0.0015351821,0.0015574256,0.004625226,0.00012695126,0.00011629274,0.00007133601,0.00027011527,0.00016086796,0.9910901,0.000012268641,0.00037023734,0.00006399564],"about_ca_topic_score_codex":0.000007469919,"about_ca_topic_score_gemma":2.1668367e-7,"teacher_disagreement_score":0.10265458,"about_ca_system_score_codex":0.000023824437,"about_ca_system_score_gemma":0.00009759804,"threshold_uncertainty_score":0.26797375},"labels":[],"label_agreement":null},{"id":"W2068257329","doi":"10.1016/j.ejmech.2011.01.026","title":"Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Traditional Chinese Medicine Analysis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Nanjing Agricultural University; Nanjing University; Chinese Academy of Sciences; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Chelation; Hydrogen bond; Intermolecular force; Broad spectrum; Absorption (acoustics); Absorption spectroscopy; Cancer cell; Lead compound; Crystal structure; Cancer; Crystallography; Stereochemistry; Molecule; Combinatorial chemistry; In vitro; Biochemistry; Inorganic chemistry; Organic chemistry","score_opus":0.041934069051875356,"score_gpt":0.2468898538345688,"score_spread":0.20495578478269344,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2068257329","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99541986,0.0013079604,0.0001006899,0.0014931484,0.00014633399,0.00010114579,0.0000085408565,0.000011605234,0.0014107167],"genre_scores_gemma":[0.9975467,0.00007396557,0.0006933117,0.0002502703,0.0011089161,0.000001520593,0.000002457984,0.00002762581,0.00029527195],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.997998,0.00008279063,0.0008965756,0.00019771483,0.0006440804,0.00018085574],"domain_scores_gemma":[0.99836993,0.000032839078,0.0005976119,0.00020130008,0.0004045522,0.00039374715],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00077587785,0.00018878815,0.0004951472,0.00012978622,0.00005965977,0.000008092532,0.00017351545,0.000034380508,0.0003888285],"category_scores_gemma":[0.0004986215,0.00013291193,0.00011718017,0.0002446876,0.000267576,0.00009594099,0.000040153594,0.00044844925,0.000006489776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044389878,0.000058583082,0.007033151,0.00040341952,0.00022570557,0.00022715099,0.004143646,0.000007265593,0.98593855,0.0000049429646,0.0006500001,0.00086368783],"study_design_scores_gemma":[0.0016095109,0.0005089565,0.09820212,0.0014032836,0.00054893526,0.0016695906,0.0011279574,0.000042176052,0.8944981,0.000066647895,0.00017252828,0.00015018311],"about_ca_topic_score_codex":0.00009041967,"about_ca_topic_score_gemma":0.0000028133784,"teacher_disagreement_score":0.09144043,"about_ca_system_score_codex":0.00006961654,"about_ca_system_score_gemma":0.00013926075,"threshold_uncertainty_score":0.5419991},"labels":[],"label_agreement":null},{"id":"W2070592884","doi":"10.1016/j.ejmech.2008.03.015","title":"The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones","year":2008,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":54,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Toxicity; Cytotoxic T cell; Stereochemistry; Cytotoxicity; Molecule; In vitro; Biochemistry; Organic chemistry","score_opus":0.024550184773453002,"score_gpt":0.20878101582157887,"score_spread":0.18423083104812588,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2070592884","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98947006,0.007458505,0.000052379062,0.0011497719,0.00023537003,0.00011707375,0.00005102546,0.00004983878,0.0014159862],"genre_scores_gemma":[0.9929726,0.0030454353,0.00015273086,0.0002376383,0.0019282001,0.000006545831,0.000005007447,0.000064004,0.0015878202],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99635714,0.00035330924,0.001123547,0.00061810244,0.000884509,0.000663411],"domain_scores_gemma":[0.9970567,0.00077444525,0.000733804,0.00041626676,0.00025944275,0.0007592891],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0014841731,0.000602005,0.0008595853,0.000049994065,0.0006684006,0.00016431515,0.0008288808,0.00016922729,0.00021462596],"category_scores_gemma":[0.0016816945,0.00035712408,0.00023516265,0.00013977132,0.00078358385,0.00027174503,0.00040571054,0.0009921374,0.000008744755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007999987,0.00019525434,0.00087033934,0.00020404522,0.00014495598,0.0002681282,0.000280592,0.000005149668,0.9908832,0.0000020548719,0.0023649419,0.0039813826],"study_design_scores_gemma":[0.0010915996,0.00031268664,0.0030009025,0.0004101714,0.00012664942,0.00076062,0.00076877244,0.00002347528,0.981193,0.000023718343,0.0117976,0.0004907795],"about_ca_topic_score_codex":0.000018406805,"about_ca_topic_score_gemma":0.0000024111746,"teacher_disagreement_score":0.009690133,"about_ca_system_score_codex":0.00009312668,"about_ca_system_score_gemma":0.00012925072,"threshold_uncertainty_score":0.99988806},"labels":[],"label_agreement":null},{"id":"W2072596973","doi":"10.1016/j.ejmech.2011.01.012","title":"α-d-Mannose derivatives as models designed for selective inhibition of Golgi α-mannosidase II","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"European Regional Development Fund; Agentúra na Podporu Výskumu a Vývoja","keywords":"Chemistry; Mannose; Mannosidase; Golgi apparatus; IC50; Stereochemistry; Enzyme; Iminosugar; Biochemistry; In vitro; Endoplasmic reticulum","score_opus":0.037566041266792534,"score_gpt":0.2358290733059955,"score_spread":0.19826303203920298,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2072596973","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.86813366,0.00041444084,0.0018452919,0.00007454294,0.00004287214,0.000056971076,0.00003197731,0.000025718746,0.1293745],"genre_scores_gemma":[0.996823,0.000058216105,0.0015355224,0.000049095557,0.0005592028,0.000005038227,0.00001801138,0.000056772435,0.00089513697],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99788404,0.000073163385,0.0009995021,0.00028352122,0.0004472921,0.0003124927],"domain_scores_gemma":[0.99744105,0.00020806423,0.0011028049,0.0002916688,0.0006758981,0.00028050877],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008879932,0.00031254865,0.0005286782,0.000055937388,0.00013555624,0.000012121147,0.00039372055,0.00010336504,0.00074035826],"category_scores_gemma":[0.0007419542,0.00028194473,0.0003247265,0.00015716883,0.00026379715,0.0002272749,0.00008291,0.00042644917,0.00000292343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001235621,0.00031104442,0.000027948705,0.0005614972,0.00021019435,0.00030603335,0.0033988506,0.00002110926,0.99137276,0.000027811044,0.0012365758,0.0012905519],"study_design_scores_gemma":[0.0017771731,0.00029749988,0.000027160588,0.0008461706,0.0002202998,0.00041424634,0.0019859236,0.000060446462,0.99271405,0.0010338097,0.0003630516,0.0002601662],"about_ca_topic_score_codex":0.00000383087,"about_ca_topic_score_gemma":1.2846732e-7,"teacher_disagreement_score":0.12868932,"about_ca_system_score_codex":0.00009329428,"about_ca_system_score_gemma":0.00017707552,"threshold_uncertainty_score":0.9999633},"labels":[],"label_agreement":null},{"id":"W2073971889","doi":"10.1016/j.ejmech.2011.05.058","title":"Synthesis and biological evaluation of the glycoside (25R)-3β,16β-diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside: A selective anticancer agent in cervicouterine cell lines","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; HeLa; Diosgenin; Cytotoxic T cell; Apoptosis; Glycoside; Cytotoxicity; Cell culture; Cancer cell; Programmed cell death; Biological activity; Cell growth; Cell cycle; Stereochemistry; Biochemistry; Cancer; Cell; Pharmacology; In vitro; Biology","score_opus":0.030865735572228728,"score_gpt":0.2531132028002294,"score_spread":0.2222474672280007,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2073971889","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9931548,0.0034597914,0.00005151249,0.00020419186,0.000097977725,0.00011982298,0.00000924666,0.000003350101,0.0028992675],"genre_scores_gemma":[0.99818593,0.001055043,0.00016545849,0.0001219551,0.00041683772,0.0000070865935,0.0000016393153,0.000018254648,0.000027798718],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984295,0.00031621978,0.00046925963,0.00022742829,0.0003561952,0.00020141374],"domain_scores_gemma":[0.99901456,0.00006196488,0.00038951056,0.00018008948,0.0002596567,0.00009424268],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012350844,0.00019003329,0.00030339972,0.000022678698,0.000045727054,0.000006934475,0.00028815167,0.0000774835,0.000055104458],"category_scores_gemma":[0.00056595786,0.000119142635,0.00012403427,0.000106875435,0.0002873883,0.000007338338,0.00018569884,0.00027057732,6.820752e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037768602,0.00015565364,0.008670713,0.000073938354,0.000080689875,0.000018782262,0.00025768756,0.0000048534703,0.98638994,4.6468944e-7,0.0003176744,0.003651917],"study_design_scores_gemma":[0.0009683785,0.0002699697,0.08316075,0.00020725967,0.00011849403,0.000100291996,0.00053365104,0.00001703327,0.91391355,0.000030666142,0.0005489562,0.00013097726],"about_ca_topic_score_codex":0.000018185818,"about_ca_topic_score_gemma":0.000004132974,"teacher_disagreement_score":0.07449004,"about_ca_system_score_codex":0.00004531589,"about_ca_system_score_gemma":0.000086974,"threshold_uncertainty_score":0.48584956},"labels":[],"label_agreement":null},{"id":"W2074331690","doi":"10.1016/j.ejmech.2013.03.055","title":"Novel 3,5-bis(arylidene)-4-piperidone dimers: Potent cytotoxins against colon cancer cells","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Chemistry; Curcumin; Apoptosis; Stereochemistry; Cytotoxic T cell; Flow cytometry; Cell culture; Amide; IC50; Colorectal cancer; In vitro; Structure–activity relationship; Biochemistry; Cancer; Molecular biology; Biology","score_opus":0.019498240855599376,"score_gpt":0.22003636297620632,"score_spread":0.20053812212060695,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2074331690","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94429004,0.0010417269,0.000121943995,0.00095160294,0.00023176058,0.000047479964,0.000023468205,0.00003278416,0.053259205],"genre_scores_gemma":[0.9945858,0.000560122,0.00043007737,0.000469358,0.0021464287,0.0000043308933,0.000004721574,0.00004121738,0.0017579438],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99785435,0.000067777146,0.0007699721,0.00030712955,0.0005823763,0.0004183799],"domain_scores_gemma":[0.9980557,0.00016267184,0.0007586929,0.00028746773,0.0002602604,0.00047518144],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006455664,0.000323662,0.000515857,0.000028155107,0.000105319144,0.000058231373,0.00064482377,0.00011033879,0.0066745756],"category_scores_gemma":[0.00026396615,0.00022215562,0.0002794229,0.000098272205,0.0002174113,0.00014531016,0.00013143524,0.0008047995,0.00007798676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009973665,0.00029383771,0.00027022173,0.000115775525,0.00011616086,0.0002548202,0.00006485762,0.000027325877,0.97031796,3.095805e-7,0.004618039,0.023820926],"study_design_scores_gemma":[0.0011671783,0.000096212694,0.0018713677,0.00054744777,0.0000833304,0.00027403788,0.00054930116,0.00005194581,0.97885066,0.0000027718906,0.016203195,0.0003025238],"about_ca_topic_score_codex":0.0000377462,"about_ca_topic_score_gemma":6.1703435e-7,"teacher_disagreement_score":0.051501263,"about_ca_system_score_codex":0.00016799154,"about_ca_system_score_gemma":0.000114037095,"threshold_uncertainty_score":0.9942334},"labels":[],"label_agreement":null},{"id":"W2076764177","doi":"10.1016/j.ejmech.2013.06.015","title":"Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Chromone; Alkaline phosphatase; Enzyme; Isozyme; Phosphatase; Sulfonamide; Biochemistry; Non-competitive inhibition; Docking (animal); Stereochemistry","score_opus":0.013876082791369796,"score_gpt":0.2725754677573387,"score_spread":0.2586993849659689,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2076764177","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98604107,0.011038385,0.000488385,0.0016186928,0.00006523473,0.00020940398,0.000060648537,0.0000096036665,0.0004685627],"genre_scores_gemma":[0.99775636,0.00093659107,0.0006978958,0.000081432176,0.00034220325,0.000002129204,0.000036291458,0.000027225833,0.000119862605],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9974957,0.00008003947,0.0011087791,0.0001910717,0.0009160936,0.00020829888],"domain_scores_gemma":[0.9969286,0.00021198933,0.0010466856,0.00022341975,0.0013036341,0.00028572362],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013617078,0.00019094239,0.0005609382,0.00009357681,0.000046615136,0.000009935191,0.00016536913,0.0000345144,0.00009175475],"category_scores_gemma":[0.0020004082,0.00014453096,0.00012036504,0.00025318717,0.0004991701,0.00012749253,0.00007786646,0.0003638273,0.000005627686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00051420444,0.0005024449,0.0010450234,0.00081052183,0.00029023943,0.00020174049,0.0001975192,0.000019290603,0.98846036,0.000005273541,0.0049170223,0.0030363686],"study_design_scores_gemma":[0.004009952,0.0009852409,0.020474484,0.0012620888,0.0002651132,0.00051408994,0.0007257695,0.00026745079,0.97103375,0.000019992121,0.0003311841,0.000110903195],"about_ca_topic_score_codex":0.00005017862,"about_ca_topic_score_gemma":2.3037086e-7,"teacher_disagreement_score":0.01942946,"about_ca_system_score_codex":0.00007147794,"about_ca_system_score_gemma":0.00023967765,"threshold_uncertainty_score":0.58938015},"labels":[],"label_agreement":null},{"id":"W2077703968","doi":"10.1016/j.ejmech.2011.07.005","title":"Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Bovine serum albumin; Tamoxifen; Serum albumin; Albumin; Pharmacology; Biochemistry; Internal medicine; Cancer; Breast cancer; Biology","score_opus":0.02309388903632065,"score_gpt":0.2451053117281309,"score_spread":0.22201142269181026,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2077703968","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98841244,0.007459245,0.000081895196,0.00028585026,0.00004558417,0.0000420963,0.0000070487235,0.0000021763817,0.003663678],"genre_scores_gemma":[0.9973842,0.0016385125,0.00019851011,0.00015742525,0.00041347436,8.3641316e-7,0.000002360261,0.000012964673,0.00019172876],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989616,0.00009481078,0.000398872,0.00016667349,0.00022849783,0.00014951477],"domain_scores_gemma":[0.9990995,0.000041623338,0.00043155724,0.00015047465,0.00017907571,0.000097782206],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008539796,0.00014092488,0.00023806891,0.000033600532,0.00008810566,0.0000115372695,0.00019974053,0.000031537442,0.000056637713],"category_scores_gemma":[0.00043313787,0.00009055613,0.00007827365,0.000080095124,0.0001692224,0.000009823192,0.00012199897,0.00022059628,0.000001515556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001824825,0.000029698742,0.0047110617,0.0000646408,0.00021634896,0.000030215408,0.00037428268,0.0000012459286,0.9914457,0.0000062477684,0.00024779607,0.0026902778],"study_design_scores_gemma":[0.0005031202,0.00037956974,0.005198648,0.0001616688,0.00016298535,0.00020587757,0.000864261,0.00003268455,0.9909042,0.000007250011,0.0014752445,0.00010448703],"about_ca_topic_score_codex":0.0000041140866,"about_ca_topic_score_gemma":4.659711e-7,"teacher_disagreement_score":0.008971762,"about_ca_system_score_codex":0.000005981798,"about_ca_system_score_gemma":0.000024019448,"threshold_uncertainty_score":0.3692772},"labels":[],"label_agreement":null},{"id":"W2078173600","doi":"10.1016/j.ejmech.2008.02.017","title":"Novel imidazo[1,2-a]naphthyridinic systems (part 1): Synthesis, antiproliferative and DNA-intercalating activities","year":2008,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"","keywords":"Chemistry; Intercalation (chemistry); Agarose gel electrophoresis; Amsacrine; In vitro; DNA; Mechanism of action; Cytotoxicity; Stereochemistry; Cell culture; Biochemistry; Combinatorial chemistry; Organic chemistry","score_opus":0.02447810014662111,"score_gpt":0.2330619841309618,"score_spread":0.2085838839843407,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078173600","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99073714,0.0033732704,0.0024012334,0.00012360657,0.0003215944,0.000050491464,0.000013734113,0.000005977209,0.0029729607],"genre_scores_gemma":[0.99641633,0.0012714666,0.00019560073,0.00012477885,0.0016839284,0.000001687826,0.000004409,0.000034121735,0.00026768894],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99883914,0.0000881964,0.00042213223,0.0002013222,0.00024825154,0.00020096688],"domain_scores_gemma":[0.99912685,0.000038815942,0.00037515533,0.00016932753,0.00011798486,0.00017189106],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006463494,0.00018536019,0.00027588647,0.00002871049,0.0000978317,0.000023859297,0.00019197258,0.000052785792,0.00002020468],"category_scores_gemma":[0.00012822961,0.00015515555,0.000098610915,0.000040862502,0.00016628647,0.000008832136,0.0000732147,0.00023511815,0.0000011285238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019297923,0.000043656215,0.00013026329,0.000059825426,0.00014170176,0.00013197935,0.0002122786,0.00003323179,0.99733996,0.0000055349656,0.0006719842,0.0010365869],"study_design_scores_gemma":[0.0010402178,0.00041071844,0.00025185393,0.0003727808,0.00007104269,0.0068380176,0.0009838254,0.00007030655,0.96622795,0.0000022489658,0.02352027,0.00021078959],"about_ca_topic_score_codex":0.000001584583,"about_ca_topic_score_gemma":2.48278e-7,"teacher_disagreement_score":0.03111205,"about_ca_system_score_codex":0.000021041187,"about_ca_system_score_gemma":0.00011044772,"threshold_uncertainty_score":0.632706},"labels":[],"label_agreement":null},{"id":"W2078641102","doi":"10.1016/s0223-5234(00)00123-9","title":"Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds","year":2000,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":278,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Neurological Disorders and Stroke; University of Utah","keywords":"Chemistry; Hydrogen bond; Molecule; Anticonvulsant; Stereochemistry; Atomic charge; Computational chemistry; Carbonyl group; Hydrogen; Organic chemistry; Medicinal chemistry","score_opus":0.012878256577976279,"score_gpt":0.2156579954718311,"score_spread":0.2027797388938548,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078641102","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900358,0.0057602576,0.0028455462,0.0005556623,0.0001158242,0.00006036499,0.0000034591055,0.000025527988,0.0005975949],"genre_scores_gemma":[0.98993075,0.00040761818,0.009330518,0.00009431481,0.00017811758,4.0535554e-7,0.0000021634444,0.000019250368,0.00003687703],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978182,0.00041283248,0.0007717082,0.0002778652,0.00051854533,0.00020089193],"domain_scores_gemma":[0.9986422,0.00027098745,0.00046716948,0.0002752044,0.00013584176,0.00020860908],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009077745,0.00023857392,0.0005094645,0.0000660503,0.00007545066,0.00009038971,0.00058581796,0.00003894217,0.000020813799],"category_scores_gemma":[0.0001589605,0.00018499058,0.000065602995,0.00019416497,0.000343654,0.00030537025,0.00015543353,0.00034495705,0.0000015062546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015910108,0.000092926704,0.0005746628,0.00019614883,0.00017430319,0.0003999622,0.0030776735,0.0005009243,0.96877784,0.000013693461,0.000042299627,0.025990464],"study_design_scores_gemma":[0.008208931,0.0009612773,0.11838109,0.0053311824,0.00056121656,0.009529628,0.0014051689,0.08411694,0.76662886,0.00279429,0.0007114401,0.0013700002],"about_ca_topic_score_codex":0.000025253163,"about_ca_topic_score_gemma":5.4859055e-7,"teacher_disagreement_score":0.202149,"about_ca_system_score_codex":0.00002564767,"about_ca_system_score_gemma":0.00012266406,"threshold_uncertainty_score":0.75436974},"labels":[],"label_agreement":null},{"id":"W2078843727","doi":"10.1016/j.ejmech.2012.04.002","title":"Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Chemistry; Cathepsin; Biochemistry; Enzyme; Papain; Cathepsin L; Non-competitive inhibition; Cysteine Proteinase Inhibitors; Cysteine; Stereochemistry","score_opus":0.017137678163925325,"score_gpt":0.25680232903888034,"score_spread":0.239664650874955,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2078843727","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9857298,0.012531588,0.00008819827,0.0000902674,0.00012321111,0.00005200699,0.000003216894,0.0000011868729,0.0013805132],"genre_scores_gemma":[0.9986304,0.0005340521,0.00015554299,0.000024428484,0.00061596575,5.1112204e-7,0.0000027094304,0.000013066461,0.000023319019],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99882525,0.00016711734,0.00037284882,0.00009536223,0.00041996923,0.000119456185],"domain_scores_gemma":[0.9990236,0.0000107955675,0.0003879673,0.00012448925,0.00031157307,0.00014153386],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0022650796,0.00010381559,0.00017356785,0.000027933786,0.000023101873,0.0000033923557,0.000087752946,0.000042905256,0.00001633845],"category_scores_gemma":[0.0003762784,0.00008281125,0.00005562217,0.00003063059,0.0001347804,0.000008642941,0.00006395448,0.00009932396,5.0065967e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007554129,0.00006409557,0.00047762608,0.00008684194,0.000053671465,0.00000505071,0.00021419274,0.000002231266,0.99063814,0.000004857566,0.00011595419,0.008261794],"study_design_scores_gemma":[0.0007827581,0.00041966746,0.0010580623,0.00024635825,0.00021844736,0.0007583773,0.00045325412,0.000008856201,0.9955303,0.00005041563,0.00039718617,0.00007632067],"about_ca_topic_score_codex":0.0000018751398,"about_ca_topic_score_gemma":7.405407e-8,"teacher_disagreement_score":0.012900594,"about_ca_system_score_codex":0.000008458113,"about_ca_system_score_gemma":0.00007507748,"threshold_uncertainty_score":0.3376945},"labels":[],"label_agreement":null},{"id":"W2079622341","doi":"10.1016/j.ejmech.2011.05.054","title":"Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre; Dalhousie University; Izaak Walton Killam Health Centre; Acadia University","funders":"University of Delhi; KU Leuven; Dalhousie University; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Chemistry; Pharmacophore; Stereochemistry; Selective estrogen receptor modulator; Estrogen receptor; Enantiomer; Moiety; Alkoxy group; Molecular model; Combinatorial chemistry; Organic chemistry; Breast cancer; Cancer","score_opus":0.021155677252023136,"score_gpt":0.2311381297853118,"score_spread":0.20998245253328868,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2079622341","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99124897,0.0022486264,0.0049586855,0.000024947713,0.00007089995,0.00006348431,0.000004443289,0.0000033773804,0.0013765455],"genre_scores_gemma":[0.9949781,0.00040575053,0.0043336223,0.000016635026,0.00020049009,8.8326374e-7,0.0000046414916,0.000023526321,0.00003638821],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99899447,0.0001628801,0.0003552389,0.00015127358,0.00019956508,0.00013654641],"domain_scores_gemma":[0.99909604,0.00002693768,0.00040591223,0.0001301777,0.00019201037,0.0001489157],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010272395,0.00013793881,0.00019469137,0.00003531675,0.00003585966,0.0000043413716,0.00016077771,0.00007094466,0.000027146954],"category_scores_gemma":[0.00029964847,0.0001094166,0.000073416646,0.00007146569,0.00013777024,0.000005938686,0.000040443727,0.00017954405,0.0000014024811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00049020833,0.000080080914,0.0004254411,0.000035087756,0.00020636196,0.000021437292,0.00021983957,0.000032618307,0.99472207,0.0000013556419,0.00028143288,0.0034840642],"study_design_scores_gemma":[0.0008909056,0.0006559314,0.0007600238,0.00012600276,0.00014183336,0.00038689474,0.00012754647,0.00007403452,0.99660045,0.000004478185,0.00012499867,0.00010689245],"about_ca_topic_score_codex":0.0000029476287,"about_ca_topic_score_gemma":3.2726376e-8,"teacher_disagreement_score":0.0037290729,"about_ca_system_score_codex":0.000014406037,"about_ca_system_score_gemma":0.00010168085,"threshold_uncertainty_score":0.44618794},"labels":[],"label_agreement":null},{"id":"W2080063197","doi":"10.1016/j.ejmech.2011.10.036","title":"Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Program for Changjiang Scholars and Innovative Research Team in University; Ministry of Science and Technology of the People's Republic of China; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Chemistry; Alkaloid; Indole test; Biological activity; Stereochemistry; Indole alkaloid; Chemical synthesis; Total synthesis; Cell culture; Tryptophan; Nuclear magnetic resonance spectroscopy; Biochemistry; Amino acid; In vitro","score_opus":0.015181700958852195,"score_gpt":0.2030751674030692,"score_spread":0.187893466444217,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2080063197","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99613124,0.0013758322,0.00003922639,0.0001268443,0.000049414546,0.00003680589,0.000009054059,0.0000013392013,0.0022302363],"genre_scores_gemma":[0.9986629,0.000703029,0.00033118195,0.000019561025,0.000199766,3.0163207e-7,4.699001e-7,0.00001251211,0.00007028343],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990617,0.0001523817,0.00033578405,0.00014281552,0.00019493708,0.000112355214],"domain_scores_gemma":[0.9990742,0.00005571774,0.0004963851,0.00017355828,0.0001059154,0.00009419751],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00072065415,0.0001328032,0.0002650555,0.000023793864,0.000036796402,0.000004589029,0.00019970942,0.000047630107,0.000038082577],"category_scores_gemma":[0.0005632318,0.000087978486,0.00010067985,0.00004617891,0.0004086661,0.00001171342,0.00021061012,0.0001443657,1.5978344e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025745755,0.000088449946,0.0075670504,0.0001364018,0.0001237418,0.000010293603,0.0001314027,1.5314845e-7,0.982042,0.000006948873,0.000027558463,0.009608549],"study_design_scores_gemma":[0.0003456911,0.0002254103,0.1432506,0.0001494296,0.00006621945,0.00028134076,0.00023290546,0.0000014513852,0.8552197,0.000018888855,0.0001317066,0.000076619566],"about_ca_topic_score_codex":0.000005783665,"about_ca_topic_score_gemma":5.2793655e-7,"teacher_disagreement_score":0.13568355,"about_ca_system_score_codex":0.000004792881,"about_ca_system_score_gemma":0.00004352876,"threshold_uncertainty_score":0.35876584},"labels":[],"label_agreement":null},{"id":"W2083337020","doi":"10.1016/j.ejmech.2009.11.020","title":"Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Radiosynthesis; Kinase; Cyclin-dependent kinase 4; Cyclin-dependent kinase; Stereochemistry; Cancer research; Biochemistry; Cyclin-dependent kinase 2; Protein kinase A; Cell cycle; In vivo; Cell; Genetics","score_opus":0.025558618042140015,"score_gpt":0.30731265734872437,"score_spread":0.2817540393065844,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083337020","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98557496,0.008617912,0.00020656029,0.0017733913,0.0001328624,0.00010473475,0.000002169078,0.000011942927,0.0035754826],"genre_scores_gemma":[0.99729574,0.00030806405,0.0008620592,0.00029488484,0.001165548,4.770135e-7,0.0000014170517,0.000016462856,0.00005537941],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99779725,0.0002323267,0.0006579721,0.00016159414,0.0009859508,0.00016490252],"domain_scores_gemma":[0.99852484,0.00008690938,0.00055211183,0.00014653537,0.00040310048,0.00028650954],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002683527,0.00016206679,0.00042883842,0.00006471749,0.000033619817,0.0000055832897,0.00012781454,0.00003839624,0.0003211172],"category_scores_gemma":[0.0006134375,0.00012094,0.0001095233,0.00009854066,0.00017480814,0.00007486597,0.000017987039,0.00040947038,0.0000017892086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011710094,0.00016137198,0.00047091555,0.000073780975,0.00009262375,0.00061761873,0.00022727648,0.000050564144,0.7461198,0.0000011885298,0.00017597337,0.25083786],"study_design_scores_gemma":[0.014578913,0.0018110028,0.05237609,0.0014754458,0.0015351784,0.008386068,0.0009754653,0.00018199884,0.9157561,0.00016305457,0.0025069697,0.00025371727],"about_ca_topic_score_codex":3.8150333e-7,"about_ca_topic_score_gemma":1.8311601e-8,"teacher_disagreement_score":0.25058416,"about_ca_system_score_codex":0.00014167838,"about_ca_system_score_gemma":0.00014102286,"threshold_uncertainty_score":0.49317902},"labels":[],"label_agreement":null},{"id":"W2083793459","doi":"10.1016/j.ejmech.2008.07.015","title":"Identification of hydrolytically stable and selective P2Y1 receptor agonists","year":2008,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"Chemistry; Nucleotide; Hydrolysis; Nucleoside; Enzyme; Receptor; Chemical synthesis; Biochemistry; Stereochemistry; Nucleoside triphosphate; Combinatorial chemistry; In vitro","score_opus":0.008158319060245186,"score_gpt":0.2184354923307945,"score_spread":0.21027717327054932,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2083793459","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9920642,0.0031288676,0.0015883873,0.00012478742,0.00005365291,0.000024614057,0.000003501471,0.000002415296,0.0030095747],"genre_scores_gemma":[0.9976496,0.00046451937,0.0004095035,0.000047818266,0.00060915144,2.3733627e-7,0.00000807328,0.000015058974,0.0007960159],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990475,0.0000712853,0.00043811242,0.00012827863,0.00020330874,0.00011149548],"domain_scores_gemma":[0.9991505,0.000017218073,0.00037082238,0.000117985735,0.00023248917,0.00011097464],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054843945,0.00009538067,0.0001597065,0.00002043258,0.00005041469,0.0000051881416,0.00014837644,0.000036265476,0.000033229546],"category_scores_gemma":[0.00024825713,0.00008258191,0.000056200854,0.0000600737,0.00015201831,0.000005474231,0.000038905055,0.0001559516,0.0000019344336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016116713,0.000039083716,0.00070580025,0.00003980292,0.00005683099,0.000061356855,0.00013335775,0.000021407086,0.990595,0.00000154821,0.007895389,0.00028926707],"study_design_scores_gemma":[0.0007313358,0.0003067659,0.0013912516,0.00006211491,0.000037493384,0.0011647259,0.00013795102,0.000016809896,0.9916254,0.0000073118645,0.0044250833,0.00009373248],"about_ca_topic_score_codex":8.137237e-7,"about_ca_topic_score_gemma":2.3051944e-8,"teacher_disagreement_score":0.0055854227,"about_ca_system_score_codex":0.000009249727,"about_ca_system_score_gemma":0.00009172047,"threshold_uncertainty_score":0.33675924},"labels":[],"label_agreement":null},{"id":"W2085084256","doi":"10.1016/j.ejmech.2015.01.022","title":"LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153–421): Design, synthesis and biochemical evaluation","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Ottawa Hospital; Health Sciences Centre","funders":"Saudi Arabian Cultural Bureau; Ottawa Hospital Research Institute","keywords":"Kexin; Chemistry; LDL receptor; PCSK9; Proprotein convertase; Reductase; Statin; Cholesterol; Biochemistry; Low-density lipoprotein; HMG-CoA reductase; Enzyme; Pharmacology; Lipoprotein; Biology","score_opus":0.05408838699581983,"score_gpt":0.2897067651186447,"score_spread":0.23561837812282485,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2085084256","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9943668,0.002464253,0.0013646334,0.0003877862,0.000049061586,0.00020473491,0.0000036896365,0.000010716374,0.0011482848],"genre_scores_gemma":[0.99612516,0.000038215792,0.0028023145,0.000032416894,0.0009499684,0.000002445152,0.0000069729763,0.00003100291,0.000011525745],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99727124,0.00051699474,0.0006035448,0.00022182848,0.0011894044,0.00019696588],"domain_scores_gemma":[0.9980078,0.00012317458,0.0005853923,0.00031035903,0.0004811778,0.00049212656],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0068443087,0.0001816196,0.0005904944,0.00005150608,0.000054735814,0.000013230866,0.00014710358,0.000060833696,0.000044371005],"category_scores_gemma":[0.0017916467,0.00014116307,0.00016380675,0.000090554175,0.00018682319,0.000077185345,0.000056912737,0.00042549794,0.000002466258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038012594,0.0001261295,0.000711631,0.00034167527,0.0002760204,0.0003151031,0.000921233,0.0000048855413,0.9698376,1.8955485e-7,0.00021168038,0.026873732],"study_design_scores_gemma":[0.00353584,0.00047832978,0.012987712,0.0015786593,0.0008740313,0.0012631194,0.001013372,0.00012230051,0.9778627,0.000062663814,0.00008162238,0.00013965857],"about_ca_topic_score_codex":0.000034439443,"about_ca_topic_score_gemma":3.172014e-7,"teacher_disagreement_score":0.026734075,"about_ca_system_score_codex":0.00016142103,"about_ca_system_score_gemma":0.00041176504,"threshold_uncertainty_score":0.5756463},"labels":[],"label_agreement":null},{"id":"W2087285032","doi":"10.1016/j.ejmech.2014.12.033","title":"Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – Neurokinin-1 antagonist peptidomimetics","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; Vlaamse regering; National Institute on Drug Abuse; Fonds Wetenschappelijk Onderzoek","keywords":"Chemistry; Pharmacology; Neuropathic pain; Pharmacophore; Analgesic; Antagonist; Agonist; Opioid; In vivo; Morphine; Chronic pain; Stereochemistry; Receptor; Biochemistry; Medicine; Neuroscience; Psychology","score_opus":0.04961203921490986,"score_gpt":0.27129068203239604,"score_spread":0.22167864281748617,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2087285032","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97455347,0.000042491858,0.000107290485,0.0002959397,0.00016533003,0.000056816814,0.00002184016,0.000010469652,0.024746355],"genre_scores_gemma":[0.99892336,0.000073841744,0.00010572484,0.0004221944,0.00043055962,3.8416556e-7,0.0000039619395,0.00001384307,0.000026157397],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99766654,0.0006206983,0.0006963564,0.00019455547,0.0006513223,0.00017051988],"domain_scores_gemma":[0.99784863,0.0007930541,0.0007378599,0.00012577414,0.00032051018,0.00017416388],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017933229,0.00016557658,0.00033881143,0.000050754337,0.000113067734,0.000029261908,0.00027111723,0.00003089301,0.00025651127],"category_scores_gemma":[0.003595252,0.00012331948,0.000099204866,0.00009204522,0.00078847643,0.000089247675,0.0000528416,0.00031787727,0.000008901598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002689805,0.00006666408,0.0002884495,0.00004545845,0.000012689422,0.000030608902,0.000041880336,0.0000788114,0.9937283,0.00024519113,0.00040805622,0.0047849137],"study_design_scores_gemma":[0.003489675,0.0015377642,0.045572072,0.00028059448,0.00021264772,0.0033977558,0.00026590534,0.002134115,0.930531,0.0004218247,0.011839848,0.00031679147],"about_ca_topic_score_codex":4.88133e-7,"about_ca_topic_score_gemma":3.1887687e-8,"teacher_disagreement_score":0.06319729,"about_ca_system_score_codex":0.000018763327,"about_ca_system_score_gemma":0.00012458183,"threshold_uncertainty_score":0.50288224},"labels":[],"label_agreement":null},{"id":"W2092211760","doi":"10.1016/j.ejmech.2010.05.046","title":"Design and synthesis of chloroquine analogs with anti-breast cancer property","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NOSM University; Laurentian University; Sudbury Regional Hospital","funders":"Ontario Ministry of Research and Innovation","keywords":"Chemistry; Trifluoromethyl; Breast cancer; Amine gas treating; Cisplatin; Cancer; Cancer cell; Chloroquine; Stereochemistry; Tertiary amine; Pharmacology; Cell culture; Cancer cell lines; Cell growth; Chemical synthesis; Cancer research; Chemotherapy; In vitro; Internal medicine; Biochemistry; Medicine; Immunology; Biology; Organic chemistry; Malaria","score_opus":0.059303318050520824,"score_gpt":0.3495110839429834,"score_spread":0.2902077658924626,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092211760","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9948898,0.0004123135,0.000294382,0.0012483085,0.0002505161,0.00005928609,0.000016863289,0.0000072737284,0.00282127],"genre_scores_gemma":[0.9980788,0.00043188917,0.00059140235,0.00017832461,0.0005063783,9.91836e-7,6.5982266e-7,0.00001946379,0.00019204905],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99893427,0.00021121411,0.0003409611,0.00013507763,0.00019907037,0.00017940775],"domain_scores_gemma":[0.99886906,0.00013733562,0.00041599205,0.0000954704,0.00024139414,0.00024074051],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012456357,0.00015420308,0.00030638528,0.00003762544,0.000077395154,0.000008655446,0.00024386363,0.000055350258,0.000830728],"category_scores_gemma":[0.00006925127,0.00008594781,0.000047030546,0.00008959242,0.00048134296,0.00006803825,0.00003877126,0.0008305131,0.0000019011961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009942891,0.0002550283,0.02306141,0.00015388105,0.00026462125,0.000661346,0.00013866663,0.000027314414,0.9511247,0.0000017610151,0.0016543785,0.021662556],"study_design_scores_gemma":[0.0034953635,0.00041225893,0.06918979,0.00047525507,0.0006389815,0.0057186577,0.00023363788,0.0002876618,0.90589654,0.00000613101,0.013362612,0.000283129],"about_ca_topic_score_codex":0.0000036303354,"about_ca_topic_score_gemma":5.002875e-7,"teacher_disagreement_score":0.046128374,"about_ca_system_score_codex":0.000012156283,"about_ca_system_score_gemma":0.00010332063,"threshold_uncertainty_score":0.9095889},"labels":[],"label_agreement":null},{"id":"W2092555782","doi":"10.1016/j.ejmech.2013.11.019","title":"Unraveling the structure–activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Staphylococcus aureus; Antibiotics; Aminoglycoside; Microbiology; Virulence; Steroid; Chemistry; Biology; Bacteria; Gene; Biochemistry; Genetics; Hormone","score_opus":0.016298818882424532,"score_gpt":0.22402790544804108,"score_spread":0.20772908656561653,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2092555782","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99319273,0.0005502041,0.0016681745,0.0005686314,0.000060428174,0.00023131316,0.000010964414,0.000012593032,0.003704938],"genre_scores_gemma":[0.99853164,0.00004543883,0.00090227777,0.00010659518,0.00025380138,2.5743765e-7,0.0000037670477,0.000044969976,0.000111227695],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99763954,0.00024677673,0.0008837011,0.000195078,0.0007742851,0.00026062108],"domain_scores_gemma":[0.9970933,0.00018882542,0.0013870955,0.00045718765,0.0006853556,0.00018822607],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014118021,0.00026592566,0.00065117655,0.00009467136,0.000098529206,0.000014754014,0.00037126304,0.00006352321,0.00001910448],"category_scores_gemma":[0.0008486397,0.00014369345,0.00024523248,0.00025900293,0.0006269205,0.00009832373,0.000056472658,0.00077554485,7.558616e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001585614,0.000121822595,0.012650375,0.0013810996,0.00026364185,0.0000921555,0.0010403349,0.00050237554,0.980431,0.0000133322965,0.00012783043,0.0017903975],"study_design_scores_gemma":[0.0033571238,0.0018122278,0.049512543,0.005702502,0.00056161254,0.00050427223,0.0027058136,0.00033831832,0.9349483,0.000018048151,0.00028859495,0.0002505915],"about_ca_topic_score_codex":0.0000036868037,"about_ca_topic_score_gemma":0.000002469063,"teacher_disagreement_score":0.04548267,"about_ca_system_score_codex":0.0000938566,"about_ca_system_score_gemma":0.00027933062,"threshold_uncertainty_score":0.5859649},"labels":[],"label_agreement":null},{"id":"W2093843448","doi":"10.1016/j.ejmech.2011.06.007","title":"Synthesis, characterization and anticancer studies of mixed ligand dithiocarbamate palladium(II) complexes","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Royal Victoria Hospital; McGill University","funders":"Higher Education Commision, Pakistan; Higher Education Commission, Pakistan","keywords":"Dithiocarbamate; Chemistry; Denticity; Ligand (biochemistry); Moiety; Palladium; Stereochemistry; Nuclear magnetic resonance spectroscopy; Medicinal chemistry; DU145; Nuclear chemistry; Crystal structure; Crystallography; Organic chemistry; Catalysis","score_opus":0.08332831833832642,"score_gpt":0.2705999958194697,"score_spread":0.18727167748114326,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2093843448","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99058264,0.00544374,0.00008613265,0.00032585693,0.00013792579,0.000055763303,0.000006256898,0.000009370831,0.0033523066],"genre_scores_gemma":[0.9965569,0.0020753732,0.0006275725,0.00010691924,0.0003863639,7.400724e-7,0.0000019105719,0.000025208554,0.00021902409],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984985,0.00014221293,0.0007119713,0.0001364516,0.00036134257,0.0001494944],"domain_scores_gemma":[0.9986578,0.000101433645,0.0005931205,0.0001678535,0.00032062765,0.00015912695],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001120824,0.00017129269,0.00065326,0.000054984397,0.00007292524,0.000006806846,0.00013679844,0.000026100355,0.00014635046],"category_scores_gemma":[0.00069406943,0.00011218649,0.00009692019,0.00007259293,0.0003617302,0.000071095106,0.000075638614,0.00020037382,0.00000200899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005891057,0.00008572888,0.0035870727,0.000809552,0.0003312363,0.00017323051,0.0014951809,6.859168e-8,0.9860472,0.000008106116,0.00021975723,0.006653758],"study_design_scores_gemma":[0.0007078476,0.00056202523,0.06863979,0.0022569308,0.00045685907,0.0009082275,0.00086161523,0.000006177589,0.922878,0.000016810345,0.002587972,0.000117685864],"about_ca_topic_score_codex":0.0000017879179,"about_ca_topic_score_gemma":1.3883782e-7,"teacher_disagreement_score":0.065052725,"about_ca_system_score_codex":0.000017024266,"about_ca_system_score_gemma":0.000046165875,"threshold_uncertainty_score":0.45748323},"labels":[],"label_agreement":null},{"id":"W2097703725","doi":"10.1016/j.ejmech.2011.08.034","title":"Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network; Hôpital Saint-François d'Assise; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Stereochemistry; Structure–activity relationship; Quantitative structure–activity relationship; In vitro; Pharmacology; Biochemistry","score_opus":0.03786759427312126,"score_gpt":0.2471409432391256,"score_spread":0.20927334896600436,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2097703725","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99292713,0.0010995499,0.0019018643,0.000118158394,0.00022970211,0.00007335417,0.000018394216,0.00001110422,0.0036207675],"genre_scores_gemma":[0.99775815,0.0005282771,0.0011131691,0.00006531935,0.00037530175,3.9072324e-7,0.000017666242,0.000029574736,0.0001121313],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986299,0.0002794397,0.0003427872,0.00029885795,0.00024485952,0.00020411321],"domain_scores_gemma":[0.99889714,0.000028120377,0.0004321404,0.00017541386,0.00024090998,0.00022629698],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006141203,0.00024048488,0.0002772062,0.000069043665,0.00018612434,0.000036663143,0.00012978063,0.00009277962,0.00007107027],"category_scores_gemma":[0.00044736013,0.0002119464,0.000087696135,0.00011426609,0.00034131313,0.000049060654,0.0000861124,0.00042063047,0.000002611512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00077388546,0.000078630634,0.008602795,0.00005832888,0.00011389711,0.00014073044,0.0002665636,0.0000046310975,0.9888909,0.000069955706,0.00039868758,0.00060102716],"study_design_scores_gemma":[0.0014454379,0.00058979535,0.10310758,0.0001383858,0.00010852742,0.0015827569,0.00034231675,0.00006357889,0.8918645,0.00008112062,0.00041753764,0.0002584645],"about_ca_topic_score_codex":0.000007708188,"about_ca_topic_score_gemma":0.0000044830617,"teacher_disagreement_score":0.09702637,"about_ca_system_score_codex":0.000014866442,"about_ca_system_score_gemma":0.00009572055,"threshold_uncertainty_score":0.8642924},"labels":[],"label_agreement":null},{"id":"W2102511297","doi":"10.1016/j.ejmech.2009.05.019","title":"Metals in anticancer therapy: Copper(II) complexes as inhibitors of the 20S proteasome","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor","funders":"National Cancer Institute","keywords":"Chemistry; Pharmacophore; Proteasome; Pyridine; Stereochemistry; Copper; Ligand (biochemistry); Apoptosis; Electron paramagnetic resonance; Protonation; Cancer cell; Ether; Crystallography; Cancer; Medicinal chemistry; Biochemistry; Receptor; Organic chemistry","score_opus":0.032362067351675385,"score_gpt":0.26957529252780765,"score_spread":0.23721322517613228,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2102511297","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96860343,0.006757041,0.000004973646,0.0044100964,0.00011221862,0.00017717363,0.0000021265564,0.000006712494,0.019926231],"genre_scores_gemma":[0.9974516,0.00037337234,0.00016675759,0.0007445034,0.0005464137,6.866324e-7,8.427388e-7,0.000019800318,0.0006960032],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9977414,0.00027101365,0.00089403,0.00014398758,0.00074154657,0.00020804566],"domain_scores_gemma":[0.9987353,0.000055904533,0.0005709414,0.0002939821,0.00019364855,0.00015023956],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016399738,0.00018949648,0.00062468037,0.00006029132,0.000064800966,0.00001020204,0.00035551764,0.000032968863,0.0004143143],"category_scores_gemma":[0.00052173634,0.00010052245,0.00024974067,0.00021189223,0.00024675677,0.00006502338,0.000050321687,0.00052666786,0.000004793589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00092120486,0.0003266599,0.0008682193,0.000098456505,0.00007710825,0.00012294337,0.00053926196,0.0000038493768,0.98371994,0.000012604763,0.0016630358,0.011646699],"study_design_scores_gemma":[0.0037685127,0.00200641,0.023996431,0.0020667482,0.000110066954,0.0010272549,0.0004463901,0.000010839475,0.94697505,0.000110751535,0.019338043,0.00014347666],"about_ca_topic_score_codex":0.0000055213113,"about_ca_topic_score_gemma":1.9733054e-7,"teacher_disagreement_score":0.03674488,"about_ca_system_score_codex":0.000039872146,"about_ca_system_score_gemma":0.00016615733,"threshold_uncertainty_score":0.4536451},"labels":[],"label_agreement":null},{"id":"W2114196925","doi":"10.1016/j.ejmech.2012.03.011","title":"Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"","keywords":"Pharmacophore; Chemistry; Cytotoxicity; Intercalation (chemistry); Topoisomerase; Stereochemistry; Pyridine; Ring (chemistry); DNA; Combinatorial chemistry; Chemical synthesis; In vitro; Medicinal chemistry; Biochemistry; Organic chemistry","score_opus":0.023089788536680568,"score_gpt":0.2491170018080599,"score_spread":0.22602721327137934,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2114196925","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99075943,0.0071342867,0.00033120008,0.00089861825,0.00050805067,0.0001566547,0.000009157098,0.0000022040265,0.00020037772],"genre_scores_gemma":[0.99788195,0.000470516,0.000008313729,0.00008121054,0.0013906298,0.0000049103687,0.0000037590808,0.000015898702,0.00014283143],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988654,0.0001443921,0.00035072444,0.00015199119,0.00030552462,0.00018195214],"domain_scores_gemma":[0.99923146,0.00001993457,0.000380696,0.00014803001,0.00011526641,0.00010458676],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014412008,0.00013510064,0.00018028429,0.000018670655,0.00008772479,0.00001568346,0.00022133293,0.000029937377,0.000014318852],"category_scores_gemma":[0.00011157887,0.00008202648,0.000050339935,0.00012353598,0.000041430038,0.000010668481,0.00012098818,0.00020761309,3.0388608e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000358729,0.000056284836,0.0009475485,0.00008349594,0.00006945138,0.0000019483737,0.00020249652,0.00014863464,0.99648845,0.000004217516,0.00041980023,0.0012189419],"study_design_scores_gemma":[0.0009885288,0.00020543132,0.0026821713,0.00029224408,0.000060902486,0.00013217726,0.00026480318,0.0001944807,0.9809272,9.034829e-7,0.014144306,0.00010684736],"about_ca_topic_score_codex":0.000003624039,"about_ca_topic_score_gemma":8.8071465e-7,"teacher_disagreement_score":0.015561247,"about_ca_system_score_codex":0.000039283295,"about_ca_system_score_gemma":0.000045229946,"threshold_uncertainty_score":0.3344943},"labels":[],"label_agreement":null},{"id":"W2124646902","doi":"10.1016/j.ejmech.2009.10.034","title":"Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":153,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"BD","keywords":"Chemistry; Escherichia coli; Antibacterial activity; Candida albicans; Carbon-13 NMR; Metal; Biological activity; Nuclear chemistry; Proton NMR; Schiff base; Stereochemistry; Bacteria; Combinatorial chemistry; Organic chemistry; In vitro; Biochemistry; Microbiology","score_opus":0.04454843864588599,"score_gpt":0.27019188142002687,"score_spread":0.2256434427741409,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2124646902","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99698806,0.00030858107,0.0001617633,0.0009116926,0.000058529524,0.00018466597,0.000026918662,0.000015033186,0.0013447312],"genre_scores_gemma":[0.9986975,0.00022225115,0.00054852525,0.00015862705,0.00029238712,9.880051e-7,0.000025419338,0.000021025196,0.000033233966],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9977024,0.00050318317,0.000616096,0.00026814552,0.0007159894,0.00019413751],"domain_scores_gemma":[0.9979579,0.000108873595,0.00088208064,0.0002086899,0.0006402619,0.00020221094],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018681086,0.00027636584,0.00081841816,0.00009007295,0.00018242262,0.000025836376,0.00015090607,0.000054931523,0.0002415329],"category_scores_gemma":[0.00065235124,0.00017768244,0.00008770202,0.00012576718,0.00039016802,0.00016465195,0.00005695893,0.00029241783,5.239702e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0034971586,0.0002586658,0.0012268175,0.00016409144,0.00018604285,0.00005050563,0.00019154794,0.0000018402624,0.9736661,9.418512e-7,0.00004023108,0.020716067],"study_design_scores_gemma":[0.0026108813,0.0017032884,0.34403008,0.0008796147,0.00068041997,0.00049949664,0.00010372447,0.00026771054,0.6487096,0.0000052989617,0.0003554501,0.00015444793],"about_ca_topic_score_codex":0.000002881276,"about_ca_topic_score_gemma":2.3872914e-7,"teacher_disagreement_score":0.34280324,"about_ca_system_score_codex":0.000050144834,"about_ca_system_score_gemma":0.00018568643,"threshold_uncertainty_score":0.7245679},"labels":[],"label_agreement":null},{"id":"W2130910636","doi":"10.1016/j.ejmech.2011.06.027","title":"Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Steroid; Estrone; Alkylation; Chemical synthesis; Reagent; Estrogen; In vitro; Steroid sulfatase; Combinatorial chemistry; Stereochemistry; Catalysis; Biochemistry; Hormone; Organic chemistry; Internal medicine","score_opus":0.026205493312399342,"score_gpt":0.24861117194682383,"score_spread":0.22240567863442448,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2130910636","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9943631,0.0020046334,0.00003137158,0.000021089421,0.00004246437,0.000055620392,0.000031226267,0.0000023914342,0.0034480975],"genre_scores_gemma":[0.99911815,0.0001713978,0.00038994598,0.000010680481,0.00023688913,0.0000010649483,0.000026248532,0.00002134448,0.000024269246],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99801356,0.00014846295,0.0009230928,0.00022650001,0.00053113356,0.0001572353],"domain_scores_gemma":[0.997789,0.000045606914,0.0011188283,0.00029655706,0.0005808335,0.0001691709],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013301278,0.00021227135,0.00039969414,0.00003173899,0.000017854916,0.0000032480857,0.00033668664,0.00012101425,0.000121614656],"category_scores_gemma":[0.0010042902,0.00018455938,0.0001467552,0.00009445009,0.00044155132,0.000009373166,0.00009723813,0.00020454334,3.2839299e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00075936905,0.00016945649,0.0013732199,0.00040776195,0.00019798915,0.0000218214,0.00025123343,0.000002228975,0.9939554,3.9030917e-7,0.00017721338,0.0026839608],"study_design_scores_gemma":[0.0013712428,0.00032942978,0.0014248755,0.0005243287,0.00027224136,0.00047918677,0.0007632345,0.0000066573793,0.99461466,0.000012387389,0.000054617987,0.00014710963],"about_ca_topic_score_codex":0.0000025607967,"about_ca_topic_score_gemma":4.6492854e-8,"teacher_disagreement_score":0.0047550537,"about_ca_system_score_codex":0.0000149671105,"about_ca_system_score_gemma":0.00017176317,"threshold_uncertainty_score":0.7526113},"labels":[],"label_agreement":null},{"id":"W2146969451","doi":"10.1016/j.ejmech.2009.04.031","title":"Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA","year":2009,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Organometallic Compounds Synthesis and Characterization","field":"Chemistry","cited_by":62,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Higher Education Commision, Pakistan; Higher Education Commission, Pakistan","keywords":"Chemistry; Trigonal bipyramidal molecular geometry; Cyclic voltammetry; Crystallography; Bipyramid; Raman spectroscopy; Piperazine; Crystal structure; Stereochemistry; Mass spectrometry; Spectroscopy; Nuclear magnetic resonance spectroscopy; Electrochemistry; Physical chemistry; Organic chemistry","score_opus":0.013210867346636191,"score_gpt":0.22010253262904206,"score_spread":0.20689166528240588,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2146969451","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9984734,0.0002529466,0.00022245508,0.00024315529,0.00004573516,0.000044657318,0.000013484978,0.000009116655,0.0006950414],"genre_scores_gemma":[0.9986961,0.00011692092,0.00070881867,0.000013993004,0.00034133522,2.0319406e-7,0.000024520614,0.000025962143,0.00007217281],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99802774,0.000093350616,0.0007817936,0.00018635398,0.0007588601,0.00015188847],"domain_scores_gemma":[0.997831,0.000091636335,0.0014224629,0.00021331821,0.00029306844,0.0001485561],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00072769535,0.00020994146,0.00046972206,0.000078560355,0.00004014059,0.000026817113,0.00023586104,0.000053839038,0.0010558213],"category_scores_gemma":[0.00040378398,0.00016289056,0.00006645214,0.0001734216,0.000080009704,0.00013835063,0.000018390776,0.0002315601,5.4969485e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013877502,0.00005384668,0.002554004,0.00016189976,0.00009751049,0.00001202822,0.0003794231,0.000014217428,0.9791889,0.0000013275807,0.000007883945,0.017390141],"study_design_scores_gemma":[0.0010624062,0.0001484411,0.040327914,0.00096374535,0.0004600568,0.00010995572,0.00021377622,0.00007135522,0.9564249,0.00001773428,0.00005791997,0.0001417792],"about_ca_topic_score_codex":7.0833363e-7,"about_ca_topic_score_gemma":1.1049606e-7,"teacher_disagreement_score":0.03777391,"about_ca_system_score_codex":0.000056666242,"about_ca_system_score_gemma":0.00018479674,"threshold_uncertainty_score":0.99985737},"labels":[],"label_agreement":null},{"id":"W2154009506","doi":"10.1016/j.ejmech.2013.01.052","title":"Synthesis of decacationic [60]fullerene decaiodides giving photoinduced production of superoxide radicals and effective PDT-mediation on antimicrobial photoinactivation","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Fullerene Chemistry and Applications","field":"Chemistry","cited_by":48,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Chemistry; Radical; Singlet oxygen; Photochemistry; Superoxide; Photoinduced electron transfer; Fullerene; Trifluoroacetic acid; Photosensitizer; Reactive oxygen species; Iodide; Electron transfer; Oxygen; Organic chemistry","score_opus":0.007670797439104578,"score_gpt":0.21168042661500494,"score_spread":0.20400962917590038,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2154009506","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9948135,0.00012384653,0.00007532044,0.0004482982,0.00006712073,0.00012755871,0.000009955307,0.000016082025,0.004318344],"genre_scores_gemma":[0.9987109,0.0001698022,0.00040397875,0.000019842135,0.00052012905,0.000015783136,0.000015944941,0.000031015767,0.000112644884],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9980979,0.00009213735,0.0009260299,0.00027859543,0.00042286035,0.00018245552],"domain_scores_gemma":[0.9973326,0.000523242,0.0012374199,0.00029747622,0.0004482411,0.0001610668],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00070175866,0.00022978461,0.00044212793,0.00007245042,0.000092888135,0.000019333263,0.0002635032,0.00009295614,0.00062722806],"category_scores_gemma":[0.001926818,0.00020654223,0.00012213088,0.00016638098,0.00025152127,0.0001734861,0.00004085485,0.00040238549,0.0000050697904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001563507,0.00021342763,0.0005088565,0.0006871783,0.00009703694,0.0000063320936,0.00022109976,0.00006101571,0.98561513,0.0000017300042,0.00061719416,0.011814666],"study_design_scores_gemma":[0.00076347275,0.00006881408,0.005447958,0.0012087288,0.0000878347,0.00016379874,0.00047527914,0.000035967627,0.9914175,0.000023141016,0.00015171748,0.00015573196],"about_ca_topic_score_codex":0.000009572905,"about_ca_topic_score_gemma":1.51909e-7,"teacher_disagreement_score":0.011658934,"about_ca_system_score_codex":0.00010459261,"about_ca_system_score_gemma":0.00009930272,"threshold_uncertainty_score":0.84225476},"labels":[],"label_agreement":null},{"id":"W2166443303","doi":"10.1016/j.ejmech.2012.07.006","title":"Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine","year":2012,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"NeurAxon (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Pharmacology; Bioavailability; hERG; Nitric oxide synthase; Indoline; In vivo; Migraine; Pharmacokinetics; Nitric oxide; Neuropathic pain; Vasodilation; Stereochemistry; Anesthesia; Medicine; Internal medicine; Potassium channel","score_opus":0.023965839965798492,"score_gpt":0.2974833805993018,"score_spread":0.2735175406335033,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2166443303","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993765,0.0046148556,0.00016876543,0.00027454735,0.00017338543,0.00043093244,0.000022444807,0.0000123824775,0.0005376659],"genre_scores_gemma":[0.99533206,0.0009126575,0.0011168022,0.00016390781,0.0014664609,0.000010051552,0.000014971922,0.00006004961,0.00092303305],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9968837,0.00024983258,0.0014842699,0.0002812303,0.00064207707,0.00045892684],"domain_scores_gemma":[0.99695677,0.00089059805,0.0010993733,0.00031266696,0.00035280452,0.00038776215],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002100836,0.00037130833,0.0009444258,0.00012636649,0.00012551667,0.000017678472,0.0002252306,0.00008072654,0.00002068633],"category_scores_gemma":[0.0009046375,0.00022990035,0.00034387282,0.00023321943,0.0003523275,0.00013445038,0.00006050878,0.00042351268,0.0000029297946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0065276213,0.0021264632,0.033221513,0.0007420888,0.0012272781,0.0004037104,0.0010837568,0.000010648201,0.9478884,0.0000063756715,0.0013287902,0.0054333946],"study_design_scores_gemma":[0.012633182,0.0044983695,0.09180036,0.0010341029,0.0014952258,0.001428162,0.00046997308,0.000018472918,0.8813299,0.000013109904,0.0049965167,0.0002826031],"about_ca_topic_score_codex":0.000033775203,"about_ca_topic_score_gemma":0.0000014916268,"teacher_disagreement_score":0.066558436,"about_ca_system_score_codex":0.0001448364,"about_ca_system_score_gemma":0.0005022264,"threshold_uncertainty_score":0.93750644},"labels":[],"label_agreement":null},{"id":"W2173064381","doi":"10.1016/j.ejmech.2005.12.014","title":"Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds","year":2006,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek","keywords":"Alicyclic compound; Chemistry; Aryl; Cytotoxic T cell; Stereochemistry; Combinatorial chemistry; Organic chemistry; In vitro; Biochemistry","score_opus":0.012558937975270986,"score_gpt":0.2259885941055758,"score_spread":0.21342965613030482,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173064381","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.88725233,0.00047700628,0.000024955581,0.00040013596,0.000115835566,0.000023882003,0.000014179433,0.000047010562,0.111644685],"genre_scores_gemma":[0.99481493,0.00007459039,0.00011566563,0.00022375163,0.0032470804,0.0000011310945,0.000014546621,0.00004413168,0.0014641706],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9975982,0.00010350665,0.0008596163,0.00033326016,0.00068023277,0.0004252071],"domain_scores_gemma":[0.99823195,0.0002569153,0.00074519834,0.00034298166,0.00013865018,0.0002842792],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00085950724,0.0003585572,0.00052032055,0.000049954277,0.00013051361,0.000047533376,0.00065045105,0.000106285945,0.0026882675],"category_scores_gemma":[0.0003090611,0.00024769126,0.00033334302,0.00013756068,0.00024023627,0.00008751209,0.00008161081,0.0005045126,0.00004690032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039545773,0.000404257,0.0019594487,0.00009184752,0.00006658309,0.0011571421,0.000017064853,0.000017629687,0.9876197,0.000008805349,0.0030009095,0.005261166],"study_design_scores_gemma":[0.0015882098,0.0002522457,0.008762736,0.0005518361,0.00010016619,0.0011326727,0.00018031009,0.000027849368,0.9574445,0.00011026603,0.02949043,0.00035878536],"about_ca_topic_score_codex":0.00001376926,"about_ca_topic_score_gemma":6.021437e-7,"teacher_disagreement_score":0.11018051,"about_ca_system_score_codex":0.00014488715,"about_ca_system_score_gemma":0.000048421152,"threshold_uncertainty_score":0.99999756},"labels":[],"label_agreement":null},{"id":"W2173107455","doi":"10.1016/s0223-5234(02)01444-7","title":"Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones","year":2003,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":95,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Chemistry; Cytotoxic T cell; Stereochemistry; Cytotoxicity; In vitro; Structure–activity relationship; Aryl; Molecule; L1210 cells; Chemical synthesis; Biochemistry; Organic chemistry","score_opus":0.02077615752077823,"score_gpt":0.22330903930451496,"score_spread":0.20253288178373674,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173107455","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.85068244,0.0012178867,0.00008200932,0.000091062335,0.00006452477,0.000011365131,0.000006748578,0.000012690905,0.14783125],"genre_scores_gemma":[0.9979668,0.00022297767,0.00044480653,0.000046720805,0.00054584886,2.9567997e-7,0.0000020295201,0.000020059302,0.00075046084],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982374,0.00015282693,0.0007542336,0.00018320224,0.000439885,0.00023247818],"domain_scores_gemma":[0.99832517,0.0002504539,0.0007904019,0.00024469322,0.00016855585,0.0002207421],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0013041567,0.00020454758,0.0004821203,0.000031167925,0.00004754269,0.000012246687,0.000422752,0.00007059494,0.0040557296],"category_scores_gemma":[0.0012480384,0.0001394341,0.0002534775,0.00010485393,0.00021592005,0.000067137466,0.000041830233,0.00043675306,0.0000099924855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009537893,0.00018232726,0.0041446076,0.00015965193,0.00008571906,0.0003945403,0.00004221926,0.0000034745215,0.99014574,0.000010621145,0.00068467896,0.0040510213],"study_design_scores_gemma":[0.0006691911,0.000111343565,0.0031256443,0.00034196454,0.00007569134,0.00090222544,0.0003976096,0.000001700006,0.9735888,0.000050628798,0.020571392,0.00016376191],"about_ca_topic_score_codex":0.0000017201228,"about_ca_topic_score_gemma":1.6011963e-7,"teacher_disagreement_score":0.14728434,"about_ca_system_score_codex":0.000037613303,"about_ca_system_score_gemma":0.00008453639,"threshold_uncertainty_score":0.9968547},"labels":[],"label_agreement":null},{"id":"W2173459804","doi":"10.1016/s0223-5234(00)00124-0","title":"N-Butyl-N-methyl-11-(3'-hydroxy-21',17'-carbolactone-19'-nor-17'α-pregna-1',3',5'(10')-trien-7'α-yl)-undecanamide: an inhibitor of type 2 17β-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity","year":2000,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Medical Research Council Canada","keywords":"Chemistry; Androgen; Stereochemistry; Cell growth; Steroid; Lactone; Microsome; Hydroxysteroid dehydrogenase; Enzyme; Cell culture; Testosterone (patch); Dehydrogenase; Biological activity; Biochemistry; IC50; Moiety; In vitro; Endocrinology; Hormone; Biology","score_opus":0.01370818409004534,"score_gpt":0.2561581767318262,"score_spread":0.24244999264178088,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2173459804","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9917092,0.0050277766,0.000060505314,0.0001884115,0.0002478741,0.00025036032,0.000116929885,0.000032025975,0.0023669177],"genre_scores_gemma":[0.98824275,0.0013754445,0.00014376178,0.00024821097,0.0010903276,0.0000038138433,0.00014429544,0.00014501231,0.008606385],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9956016,0.0007018695,0.0011604421,0.00078084046,0.0009681272,0.00078712316],"domain_scores_gemma":[0.9964392,0.00010341634,0.0010716474,0.0009483987,0.00030647227,0.0011308234],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0015223833,0.00073188497,0.0009431034,0.000116122814,0.00019153165,0.000069319736,0.0010264807,0.0004236699,0.00096435053],"category_scores_gemma":[0.0003113549,0.0005267326,0.00054817664,0.00030379018,0.000512906,0.00006419875,0.00016979445,0.00096376456,0.000021486489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.004098518,0.00046395767,0.0008874245,0.00015854786,0.00055821065,0.00097404356,0.00015385934,0.0001361455,0.9828606,2.949422e-7,0.00532095,0.0043874476],"study_design_scores_gemma":[0.0041426434,0.0024598003,0.00018128724,0.00031592365,0.0004438934,0.0021530306,0.00021231979,0.0001297734,0.96872646,0.0000041245376,0.020625686,0.0006050797],"about_ca_topic_score_codex":0.000025441928,"about_ca_topic_score_gemma":0.00001000732,"teacher_disagreement_score":0.015304736,"about_ca_system_score_codex":0.000113551,"about_ca_system_score_gemma":0.00054173614,"threshold_uncertainty_score":0.9999489},"labels":[],"label_agreement":null},{"id":"W2175377097","doi":"10.1016/j.ejmech.2004.04.004","title":"Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones","year":2004,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Memorial University of Newfoundland; Health Sciences Centre","funders":"National Research Centre","keywords":"Chemistry; Piperazine; Substituent; Antibacterial activity; Bacteria; Agar dilution; Stereochemistry; Gram; Gram-positive bacteria; Antimicrobial; Chemical synthesis; Gram-negative bacteria; In vitro; Minimum inhibitory concentration; Organic chemistry; Biochemistry; Escherichia coli","score_opus":0.01800279782629487,"score_gpt":0.22169230237700888,"score_spread":0.203689504550714,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175377097","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9907756,0.00033549566,0.00012661044,0.000437093,0.00010178231,0.000017024457,0.000017153072,0.000017499571,0.008171773],"genre_scores_gemma":[0.99836993,0.00023735245,0.0004061375,0.000020288951,0.0009189945,3.818123e-7,0.0000012783382,0.000018198807,0.000027417267],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99863094,0.00008005578,0.00051397475,0.00020873907,0.0003542496,0.00021205713],"domain_scores_gemma":[0.9984948,0.0002582686,0.0007191321,0.00019756757,0.00012381548,0.00020639689],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00079321745,0.00021597893,0.0005318989,0.000027794467,0.000063814776,0.000017499986,0.00031978663,0.00012079351,0.00062223355],"category_scores_gemma":[0.0011049495,0.00015186174,0.0001583331,0.000076869735,0.00037142562,0.00010951656,0.00008285933,0.00054240326,0.000002920163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00053381955,0.00023902008,0.0011770457,0.00022899985,0.000093102855,0.00026566506,0.000067979534,0.0000029711316,0.97629166,0.0000040607806,0.000026656713,0.02106903],"study_design_scores_gemma":[0.0010246192,0.00007125881,0.011495297,0.0005764912,0.00011153437,0.0005930599,0.00010282168,0.0000018239759,0.9849765,0.000042419204,0.0008450841,0.00015912786],"about_ca_topic_score_codex":0.000008789211,"about_ca_topic_score_gemma":3.2717094e-7,"teacher_disagreement_score":0.020909902,"about_ca_system_score_codex":0.000045016142,"about_ca_system_score_gemma":0.000076387,"threshold_uncertainty_score":0.6813021},"labels":[],"label_agreement":null},{"id":"W2175649335","doi":"10.1016/s0223-5234(02)01333-8","title":"Reactions of purines-containing butenolides with l-cysteine or N-acetyl-l-cysteine as model biological nucleophiles: a potent mechanism-based inhibitor of ribonucleotide reductase caused apoptosis in breast carcinoma MCF7 cells","year":2002,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Academia Sinica","keywords":"Chemistry; Cysteine; Glutathione; Stereochemistry; Purine; Nucleophile; Biological activity; Cytotoxicity; Biochemistry; Enzyme; In vitro","score_opus":0.025377320003667266,"score_gpt":0.21294541855035592,"score_spread":0.18756809854668866,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2175649335","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99744403,0.00011442384,0.00020074945,0.00057116646,0.000058230264,0.00006817216,0.0000844796,0.000024657671,0.0014341167],"genre_scores_gemma":[0.99839056,0.00008475481,0.0008328263,0.000058035163,0.00038215573,0.0000034604093,0.000018795325,0.00006296054,0.00016647374],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9969689,0.00011516726,0.0016047389,0.0003429204,0.0006331387,0.00033513797],"domain_scores_gemma":[0.99724257,0.0001491598,0.0015610554,0.00042114605,0.00033339107,0.0002926662],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00049735256,0.00037829843,0.00083643815,0.0001566181,0.00006735961,0.000021199805,0.00045932998,0.00009986133,0.000735868],"category_scores_gemma":[0.00017895519,0.00027385156,0.0002203158,0.0002357163,0.00022403173,0.00011501327,0.00007472209,0.0004949879,0.0000034142045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014242774,0.0005656366,0.00063424953,0.0004781405,0.00010076079,0.00056126254,0.0002992192,0.0005279862,0.99472475,0.0000031131417,0.00006467715,0.0006158986],"study_design_scores_gemma":[0.0041017593,0.001044748,0.00019648549,0.002331634,0.00013943537,0.0015995471,0.0019194059,0.0031226529,0.98512065,0.0000068431696,0.0001156546,0.00030115288],"about_ca_topic_score_codex":0.000022321252,"about_ca_topic_score_gemma":7.6037287e-7,"teacher_disagreement_score":0.009604097,"about_ca_system_score_codex":0.00012562421,"about_ca_system_score_gemma":0.00011485837,"threshold_uncertainty_score":0.9999714},"labels":[],"label_agreement":null},{"id":"W2179485306","doi":"10.1016/s0223-5234(02)01402-2","title":"Cytotoxic 1,3-diarylidene-2-tetralones and related compounds","year":2002,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"","keywords":"Chemistry; Cytotoxic T cell; Tetralones; Cytotoxicity; Nucleic acid; Stereochemistry; L1210 cells; Cell culture; Biochemistry; In vitro; Biology","score_opus":0.01749964303315209,"score_gpt":0.22195639685155039,"score_spread":0.20445675381839828,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2179485306","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93037856,0.0062339674,0.000019064244,0.004221629,0.00020834361,0.000051198498,0.0000010666855,0.000040025214,0.058846124],"genre_scores_gemma":[0.99586177,0.00059025886,0.0005062101,0.00023998454,0.00079425686,2.1699265e-7,0.0000015697836,0.000052771382,0.0019529758],"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","domain_scores_codex":[0.9980691,0.00011671084,0.0007729118,0.00019881329,0.0005926905,0.0002497855],"domain_scores_gemma":[0.9985163,0.00016386773,0.0004015914,0.0002804753,0.00016116712,0.0004765507],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0010118558,0.00021996969,0.0005019909,0.00009633292,0.00007381368,0.000026030973,0.00023745802,0.000056054057,0.0019120108],"category_scores_gemma":[0.0006864188,0.00017780412,0.00014946048,0.00017411943,0.00024949707,0.000098797194,0.00006014484,0.00068258506,0.00006572713],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022802556,0.000311077,0.009650444,0.00028428936,0.00037207725,0.009354038,0.00079001806,0.0000010966475,0.9375787,0.0000049067453,0.0262587,0.015166659],"study_design_scores_gemma":[0.020684624,0.002754716,0.21818538,0.005188961,0.001857349,0.34663218,0.0021841733,0.00039738108,0.33975425,0.00016555827,0.061008707,0.0011867047],"about_ca_topic_score_codex":7.852666e-7,"about_ca_topic_score_gemma":5.7852972e-8,"teacher_disagreement_score":0.5978244,"about_ca_system_score_codex":0.0000757614,"about_ca_system_score_gemma":0.000040373063,"threshold_uncertainty_score":0.9990004},"labels":[],"label_agreement":null},{"id":"W2181049502","doi":"10.1016/s0223-5234(02)01414-9","title":"Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds","year":2002,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Purdue University","keywords":"Chemistry; Propenyl; Aryl; Stereochemistry; Cytotoxicity; Quantitative structure–activity relationship; Structure–activity relationship; Chemical synthesis; In vitro; Medicinal chemistry; Organic chemistry; Biochemistry","score_opus":0.023414143894691396,"score_gpt":0.20763047470205465,"score_spread":0.18421633080736324,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2181049502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.833295,0.004889517,0.000011897232,0.0007203754,0.00014965232,0.000031681553,0.000008304458,0.000053183976,0.16084042],"genre_scores_gemma":[0.9951362,0.0010520446,0.0002532986,0.00013815906,0.0010564405,0.0000011615068,0.000004513179,0.000052329404,0.0023058248],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99734885,0.00015446603,0.001027055,0.00041402364,0.00061773864,0.00043788576],"domain_scores_gemma":[0.99785024,0.000316746,0.000810364,0.00037204626,0.00016420953,0.00048640367],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0012102482,0.00040989774,0.0007035551,0.000048649064,0.00016604541,0.00006930763,0.00062302744,0.00015275742,0.005617833],"category_scores_gemma":[0.00069940754,0.0002890151,0.00025805255,0.00016548876,0.00046871614,0.00015790015,0.00017864192,0.0010777762,0.000034173656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013846827,0.0002470118,0.0020381317,0.00017065836,0.00015420727,0.0012059134,0.00016298598,0.0000015875305,0.9702177,0.0000045365414,0.0015547636,0.02410403],"study_design_scores_gemma":[0.004819251,0.0005509652,0.009561131,0.0013849174,0.00040429205,0.010025788,0.0012042188,0.00028164883,0.91784483,0.00012203652,0.05267205,0.0011288484],"about_ca_topic_score_codex":0.0000035262256,"about_ca_topic_score_gemma":1.5719193e-7,"teacher_disagreement_score":0.16184126,"about_ca_system_score_codex":0.0000789626,"about_ca_system_score_gemma":0.000031214873,"threshold_uncertainty_score":0.9999562},"labels":[],"label_agreement":null},{"id":"W2188951695","doi":"10.1016/j.ejmech.2015.11.032","title":"Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Congressionally Directed Medical Research Programs; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; “la Caixa” Foundation; Fundación Ramón Areces; U.S. Department of Defense","keywords":"Lipopeptide; Biofilm; Chemistry; Cyclic peptide; Antibacterial activity; Bacteria; In vivo; Potency; Antibiotics; In vitro; Microbiology; Amino acid; Combinatorial chemistry; Structure–activity relationship; Biochemistry; Peptide; Biology; Biotechnology","score_opus":0.010607631006297719,"score_gpt":0.20988059234881024,"score_spread":0.19927296134251252,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2188951695","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99688834,0.00057088636,0.000506652,0.00012710772,0.00052316714,0.000037464386,0.000089008696,0.000013368638,0.0012439929],"genre_scores_gemma":[0.9986554,0.000055294768,0.00035622154,0.00003426164,0.000585823,1.7031024e-7,0.000057232137,0.00002148429,0.00023415899],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99902874,0.000111228124,0.0004714934,0.00014626721,0.00010006706,0.00014222592],"domain_scores_gemma":[0.9989531,0.00008610332,0.00070068036,0.00010288736,0.00009936935,0.000057831992],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034096048,0.00014968381,0.00032995254,0.000048128935,0.00006675932,0.000033950775,0.00018029442,0.000058340553,0.000089712106],"category_scores_gemma":[0.00006488053,0.0001181094,0.00005447113,0.00005795665,0.0004601402,0.00036801933,0.000064942404,0.00029704862,0.0000026168407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014973725,0.00013071814,0.00050726056,0.000037210142,0.00016319858,0.000028717015,0.0006697545,0.00000532219,0.99541533,0.000018031173,0.0008351591,0.0006919508],"study_design_scores_gemma":[0.0038153797,0.00038152307,0.0046854867,0.00053498574,0.00008906151,0.00045049348,0.0017164017,0.0000014102535,0.98783326,0.000024318984,0.0003387132,0.00012896692],"about_ca_topic_score_codex":0.000009004777,"about_ca_topic_score_gemma":1.3378944e-7,"teacher_disagreement_score":0.0075820466,"about_ca_system_score_codex":0.00001432839,"about_ca_system_score_gemma":0.00012981585,"threshold_uncertainty_score":0.48163614},"labels":[],"label_agreement":null},{"id":"W2279327176","doi":"10.1016/j.ejmech.2016.02.049","title":"Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry","year":2016,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":179,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"University of Waterloo; Ontario Ministry of Research, Innovation and Science; Ontario Mental Health Foundation","keywords":"Chemistry; Amyloid (mycology); Amyloid beta; Biochemistry of Alzheimer's disease; Senile plaques; Small molecule; Drug discovery; Dementia; Alzheimer's disease; Pharmacology; Neurodegeneration; Neuroscience; Biochemistry; Amyloid precursor protein; Disease; Medicine; Internal medicine; Biology","score_opus":0.04297715630599256,"score_gpt":0.357956543770925,"score_spread":0.3149793874649324,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2279327176","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000257553,0.98653567,0.0000046552614,0.0005390589,0.00020393153,0.00046075968,0.00007912041,0.00002243506,0.01189679],"genre_scores_gemma":[0.0020893668,0.9949598,0.000044393048,0.00007364309,0.0023614191,0.000020472491,0.00014343522,0.00015812388,0.00014939808],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99342275,0.0005534878,0.002397531,0.0007254478,0.0019386453,0.0009621687],"domain_scores_gemma":[0.99505967,0.00031868048,0.0014016709,0.0006977341,0.00031442064,0.0022077956],"candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0019287686,0.00090935634,0.0028614409,0.00031343568,0.000058752903,0.000025384128,0.00079423294,0.00021019277,0.0018076552],"category_scores_gemma":[0.0009514123,0.00058598083,0.00075295306,0.00061042485,0.0004636415,0.00021140398,0.00017374619,0.0023542196,0.00011417664],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011051798,0.00068652426,0.00035399295,0.011418641,0.0029054955,0.065411426,0.00003981406,5.201682e-7,0.000024193161,5.2030754e-7,0.0011830503,0.91687065],"study_design_scores_gemma":[0.0058293315,0.0002718432,0.00031019573,0.11373096,0.00410112,0.0044365227,0.000097435375,0.0000010013887,0.00010999576,0.000015281164,0.87060463,0.00049164955],"about_ca_topic_score_codex":0.0000022313034,"about_ca_topic_score_gemma":7.06378e-7,"teacher_disagreement_score":0.916379,"about_ca_system_score_codex":0.0007791035,"about_ca_system_score_gemma":0.0028142645,"threshold_uncertainty_score":0.99994737},"labels":[],"label_agreement":null},{"id":"W2288721621","doi":"10.1016/j.ejmech.2016.02.073","title":"2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Alkoxy group; Stereochemistry; Active site; Enzyme inhibitor; Non-competitive inhibition; Nucleotidase; Selectivity; Ethanol; Enzyme; Phosphatase; Biochemistry; Organic chemistry; Catalysis; Alkyl","score_opus":0.005738071015641725,"score_gpt":0.21311354444231567,"score_spread":0.20737547342667395,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2288721621","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98808855,0.007429429,0.00042320532,0.00035764213,0.00008308985,0.00003336345,0.000007002768,0.000004057836,0.0035736698],"genre_scores_gemma":[0.9973081,0.0008558832,0.00020507012,0.0000788501,0.0010941937,3.5115153e-7,0.0000036186361,0.000026937165,0.0004270395],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987902,0.00011268677,0.00047595266,0.00019440887,0.00025319916,0.00017353972],"domain_scores_gemma":[0.99895865,0.00005027449,0.00043406832,0.00015547943,0.00022991147,0.00017163942],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000563633,0.00016998945,0.00024495836,0.00004494188,0.000040939092,0.0000070074893,0.00019924602,0.00005092325,0.0000657866],"category_scores_gemma":[0.0004023873,0.00011218908,0.00011138261,0.00007286524,0.00021206478,0.000008304918,0.000093828094,0.00013604548,0.0000033280876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021838033,0.000049859635,0.0015231761,0.000056096982,0.000106139036,0.00019372338,0.00006818706,0.0000053469826,0.98737615,0.0000024294638,0.0045489026,0.005851583],"study_design_scores_gemma":[0.0013431887,0.00084966014,0.0029131994,0.00035398142,0.00006868507,0.0012441413,0.0002390305,7.3868074e-7,0.9861146,0.000027785003,0.0066944594,0.00015052297],"about_ca_topic_score_codex":0.0000023353984,"about_ca_topic_score_gemma":7.507305e-8,"teacher_disagreement_score":0.009219517,"about_ca_system_score_codex":0.000013694521,"about_ca_system_score_gemma":0.000090054986,"threshold_uncertainty_score":0.45749378},"labels":[],"label_agreement":null},{"id":"W2300717780","doi":"10.1016/j.ejmech.2016.03.004","title":"Design and synthesis of novel protein kinase CK2 inhibitors on the base of 4-aminothieno[2,3-d]pyrimidines","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ontario Tobacco Research Unit","funders":"National Academy of Sciences of Ukraine","keywords":"Chemistry; Pyrimidine; Benzoic acid; Stereochemistry; Hydrogen bond; Intramolecular force; IC50; Active site; Medicinal chemistry; Enzyme; In vitro; Molecule; Organic chemistry; Biochemistry","score_opus":0.021313380341774234,"score_gpt":0.22123745029995318,"score_spread":0.19992406995817893,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2300717780","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9847636,0.0008355464,0.012727133,0.0009377551,0.000033822125,0.00011837239,0.000008336252,0.0000025890747,0.0005728348],"genre_scores_gemma":[0.9979239,0.000081833954,0.0015201967,0.000051871546,0.00031161198,0.0000020336095,7.633143e-7,0.00001947186,0.000088324894],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99876434,0.00019106448,0.0004824552,0.00014391889,0.00028839897,0.0001298225],"domain_scores_gemma":[0.998756,0.0001241728,0.0005796143,0.00021530836,0.00021291844,0.000111981215],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016844149,0.00013976717,0.00020131952,0.000039744547,0.000038157326,0.0000053022386,0.00020667975,0.000045266668,0.00003601278],"category_scores_gemma":[0.0012770976,0.000075747324,0.00009053001,0.000065095664,0.00027071283,0.000005440609,0.000053230757,0.00010448122,5.704989e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036425196,0.00009732418,0.000033379514,0.0000872108,0.00004196709,0.000027040956,0.000031602205,0.000025762803,0.99198633,0.000017939268,0.0002783016,0.0070088697],"study_design_scores_gemma":[0.0009546941,0.00036818816,0.000117752796,0.0011361574,0.000036222285,0.00009593717,0.00009558979,0.000015359863,0.9963764,0.00001085027,0.00070438546,0.000088478744],"about_ca_topic_score_codex":6.0610324e-7,"about_ca_topic_score_gemma":3.655305e-8,"teacher_disagreement_score":0.013160282,"about_ca_system_score_codex":0.0000098040255,"about_ca_system_score_gemma":0.00008045524,"threshold_uncertainty_score":0.3088886},"labels":[],"label_agreement":null},{"id":"W2301073084","doi":"10.1016/j.ejmech.2016.03.026","title":"Transfer of SAR information from hypotensive indazole to indole derivatives acting at α-adrenergic receptors: In vitro and in vivo studies","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Indazole; Chemistry; In vivo; In vitro; Indole test; Adrenergic receptor; Receptor; Pharmacology; Adrenergic; Stereochemistry; Biochemistry; Biology","score_opus":0.04774638183439676,"score_gpt":0.309963842500054,"score_spread":0.2622174606656572,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2301073084","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99816996,0.00010355281,0.000024936558,0.0012502132,0.00013996026,0.000066757355,0.000009597403,0.0000041335943,0.00023086352],"genre_scores_gemma":[0.99853677,0.0005521727,0.000031132306,0.0007402404,0.00008922359,7.1466803e-7,9.456251e-8,0.00000921039,0.00004044194],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982394,0.0003501007,0.00057637057,0.00018496418,0.00041817783,0.00023100572],"domain_scores_gemma":[0.99883497,0.0006475467,0.00018819778,0.00008375935,0.00010262628,0.00014289003],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007142689,0.0001251914,0.00028623466,0.00018579485,0.00005014678,0.000009443783,0.0002876367,0.000023223598,0.000045462544],"category_scores_gemma":[0.0024088041,0.00008442602,0.000033179258,0.0003209208,0.0003356042,0.0004887419,0.00013783987,0.0003083858,0.0000043873943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009627596,0.000027591284,0.0007029807,0.000027688038,0.000004075341,0.00034119282,0.0017988173,0.000012768241,0.9897874,2.1938402e-7,0.00010222967,0.0062322817],"study_design_scores_gemma":[0.0017373348,0.00016527926,0.0015885872,0.00031688114,0.0000056182785,0.00010349104,0.0009123799,0.000005357359,0.99436474,0.000008048185,0.00071349554,0.00007876346],"about_ca_topic_score_codex":0.0000017683271,"about_ca_topic_score_gemma":3.9967978e-7,"teacher_disagreement_score":0.0061535183,"about_ca_system_score_codex":0.000067567205,"about_ca_system_score_gemma":0.00005552689,"threshold_uncertainty_score":0.34427932},"labels":[],"label_agreement":null},{"id":"W2316109466","doi":"10.1016/j.ejmech.2016.04.021","title":"New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Dalhousie University; National Research Council Canada; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Université de Moncton","keywords":"Adipose triglyceride lipase; Lipolysis; Chemistry; Triglyceride; Adipose tissue; Lipase; Carbamate; Enzyme; Lipid droplet; Biochemistry; Cholesterol","score_opus":0.011235424581128178,"score_gpt":0.22299898750770825,"score_spread":0.21176356292658008,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2316109466","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99505955,0.001205222,0.0013514712,0.0007045345,0.0001574183,0.00004787884,0.00004057113,0.000010672565,0.0014226955],"genre_scores_gemma":[0.9962898,0.00027467194,0.001334037,0.000061949395,0.0012931341,4.810605e-7,0.00001212478,0.000032482185,0.0007013202],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983996,0.00029221893,0.00052829785,0.0002711181,0.00029876307,0.00020997094],"domain_scores_gemma":[0.99864674,0.00010525631,0.00051606144,0.00024567114,0.00013375186,0.00035252084],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00087001367,0.00021948446,0.0002892072,0.000055104196,0.000084575404,0.000023681538,0.00017729626,0.0001085833,0.00014499664],"category_scores_gemma":[0.0019224698,0.00014417912,0.00011665154,0.00009659172,0.0001484153,0.000023285857,0.000065353684,0.00022849508,0.0000051373827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048802784,0.000027402759,0.00074396445,0.00004239861,0.0000838299,0.000093490205,0.000084061736,6.842637e-7,0.8953289,0.0000044549643,0.0016953548,0.10140747],"study_design_scores_gemma":[0.0014481341,0.00016822563,0.025921408,0.00028100854,0.00016809283,0.0005848776,0.00006303773,9.4023727e-7,0.9539922,0.000046914593,0.017117012,0.00020813255],"about_ca_topic_score_codex":0.000004523859,"about_ca_topic_score_gemma":0.0000016947496,"teacher_disagreement_score":0.10119934,"about_ca_system_score_codex":0.000026386277,"about_ca_system_score_gemma":0.00022117357,"threshold_uncertainty_score":0.5879454},"labels":[],"label_agreement":null},{"id":"W2322695360","doi":"10.1016/j.ejmech.2016.04.010","title":"Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Drugs for Neglected Diseases initiative; School of Medicine, New York University; York University; NorthShore University HealthSystem; Bill and Melinda Gates Foundation","keywords":"Chemistry; Lipophilicity; Trypanosoma brucei; Trypanosoma cruzi; Benznidazole; Leishmania donovani; Trypanosoma brucei rhodesiense; Amastigote; Leishmania; Nitro; Chagas disease; Stereochemistry; Active compound; Antiprotozoal; Biochemistry; In vitro; Organic chemistry; Parasite hosting; Biology","score_opus":0.025332608874296163,"score_gpt":0.2810116753257383,"score_spread":0.2556790664514421,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2322695360","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9638022,0.0002922693,0.0029901776,0.0052915467,0.00008415352,0.000070292,0.000023283741,0.000017066552,0.027428987],"genre_scores_gemma":[0.99751484,0.00007239828,0.00079116196,0.00013351937,0.0006919888,5.7983283e-7,0.0000029733953,0.000027328195,0.00076521933],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9980733,0.00012105848,0.0005614075,0.0001549507,0.00081228034,0.00027705127],"domain_scores_gemma":[0.9979582,0.00020141645,0.00048733756,0.00037003285,0.00052997353,0.0004530627],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019976126,0.00015620439,0.00041192354,0.00010409465,0.000050089093,0.000009043066,0.00031596777,0.00004201059,0.00058339705],"category_scores_gemma":[0.00071743684,0.00009627658,0.0002168758,0.00018783401,0.0004341744,0.00009768679,0.00004917338,0.00040486068,0.000025146559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00082642806,0.00028119312,0.0045115156,0.0001715289,0.00008213298,0.00035311343,0.000022186652,4.1678032e-7,0.97704273,0.000007705472,0.0050241374,0.011676936],"study_design_scores_gemma":[0.0044352487,0.00076066056,0.2573671,0.0007583837,0.000081822334,0.001102752,0.00004582379,0.0000072712037,0.72111076,0.000008747173,0.014225996,0.00009544134],"about_ca_topic_score_codex":0.0000020680632,"about_ca_topic_score_gemma":1.3995815e-7,"teacher_disagreement_score":0.25593197,"about_ca_system_score_codex":0.00009531718,"about_ca_system_score_gemma":0.0004243189,"threshold_uncertainty_score":0.63877887},"labels":[],"label_agreement":null},{"id":"W2341358752","doi":"10.1016/j.ejmech.2016.04.027","title":"New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Cape Breton University","funders":"French Infrastructure for Integrated Structural Biology; Universiti Putra Malaysia; Ministry of Higher Education, Malaysia; Agence Nationale de la Recherche","keywords":"Chemistry; Electron paramagnetic resonance; Molar conductivity; Copper; Antibacterial activity; Nuclear chemistry; Cytotoxicity; Antibacterial agent; Electrochemistry; Pyrrole; Magnetic susceptibility; Inorganic chemistry; Crystallography; Stereochemistry; Bacteria; Organic chemistry; Elemental analysis; In vitro; Physical chemistry; Nuclear magnetic resonance; Biochemistry","score_opus":0.02970457529949263,"score_gpt":0.24199019041021075,"score_spread":0.2122856151107181,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2341358752","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9850277,0.009034878,0.00047726062,0.0027441978,0.00008512787,0.00007000354,0.0000043432397,0.000015596012,0.0025408932],"genre_scores_gemma":[0.9960642,0.00083445053,0.001814722,0.0002321352,0.000943371,3.909394e-7,0.000006136139,0.000022324479,0.00008229515],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9981946,0.00022189162,0.0007000694,0.00022761448,0.00043391733,0.00022192446],"domain_scores_gemma":[0.9984602,0.000343628,0.00045673412,0.00026623285,0.00015665412,0.00031659316],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004348612,0.00024336933,0.00060051796,0.000038569546,0.00012096554,0.000016145212,0.000341593,0.000051760653,0.0005976788],"category_scores_gemma":[0.0010041111,0.00010356339,0.00014937553,0.00008462099,0.00055858755,0.000070330316,0.00014372666,0.00039580624,0.0000037095117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089451316,0.000026230988,0.0015245385,0.00004496797,0.00017921637,0.000119697375,0.00053887046,8.392863e-8,0.98689353,0.000026062895,0.00026552586,0.009486758],"study_design_scores_gemma":[0.001980606,0.0005371248,0.029402744,0.0009282366,0.00020229795,0.0008556899,0.00015978499,0.000007536962,0.9614068,0.00044360702,0.003926599,0.0001489618],"about_ca_topic_score_codex":0.000022414373,"about_ca_topic_score_gemma":0.0000013479969,"teacher_disagreement_score":0.027878204,"about_ca_system_score_codex":0.00003278934,"about_ca_system_score_gemma":0.00013165253,"threshold_uncertainty_score":0.6544164},"labels":[],"label_agreement":null},{"id":"W2342266414","doi":"10.1016/j.ejmech.2016.04.044","title":"Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; PROTEO; Centre hospitalier universitaire de Québec","funders":"Fondation du cancer du sein du Québec; Fondation Cancer","keywords":"Chemistry; Steroid sulfatase; Selective estrogen receptor modulator; Estrogen receptor; Steroid; Estrogen; Pharmacology; Alkaline phosphatase; In vitro; Enzyme; Biochemistry; Hormone; Endocrinology; Internal medicine; Cancer; Breast cancer; Biology","score_opus":0.005597817294712854,"score_gpt":0.18669267199518993,"score_spread":0.1810948547004771,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2342266414","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9962441,0.002424268,0.00068157195,0.00020409252,0.00009619982,0.00009990328,0.000028792861,0.000007289591,0.00021383546],"genre_scores_gemma":[0.9985859,0.00015335696,0.00031755376,0.000046935973,0.00061895023,0.000001814188,0.00001700699,0.00004770943,0.00021079964],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.998466,0.00019057767,0.0004997234,0.00023957946,0.00035890657,0.00024520172],"domain_scores_gemma":[0.9986974,0.00002501665,0.0005335632,0.00026614504,0.00029988337,0.00017797724],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00051785243,0.00024005018,0.0003132341,0.000046226134,0.000042613334,0.000015612164,0.00028433747,0.00008012043,0.000011149774],"category_scores_gemma":[0.00020314766,0.00012960295,0.00014039617,0.000103238715,0.00030325082,0.0000200182,0.000060427163,0.00023980186,0.0000050952744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0030044138,0.00012870829,0.0013802884,0.00011232461,0.00022048812,0.0001425231,0.000044382177,0.0000206456,0.99120563,0.0000010064371,0.0010438847,0.0026957016],"study_design_scores_gemma":[0.0033205384,0.0021424778,0.00042483635,0.0008423483,0.000091926304,0.00034906616,0.00008137014,0.0000024186345,0.9916113,0.0000010677289,0.00094829267,0.00018435865],"about_ca_topic_score_codex":0.0000012497097,"about_ca_topic_score_gemma":1.226494e-7,"teacher_disagreement_score":0.002511343,"about_ca_system_score_codex":0.000040806593,"about_ca_system_score_gemma":0.00030498632,"threshold_uncertainty_score":0.5285055},"labels":[],"label_agreement":null},{"id":"W2346040430","doi":"10.1016/j.ejmech.2016.05.008","title":"Novel spirothiazamenthane inhibitors of the influenza A M2 proton channel","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University; University of British Columbia; Centre for Drug Research and Development","funders":"","keywords":"Chemistry; Yeast; Amantadine; Mutant; Influenza A virus; Potency; High-throughput screening; Virus; Virology; Biochemistry; In vitro; Biology; Gene","score_opus":0.06500556906210811,"score_gpt":0.3261272836540908,"score_spread":0.26112171459198275,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2346040430","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9800262,0.0018780276,0.0002176453,0.004584624,0.00024112767,0.0004584561,0.000012709327,0.000015454447,0.012565791],"genre_scores_gemma":[0.99667937,0.00016142252,0.00017859972,0.0007220474,0.001358978,0.0000049174105,2.4961787e-7,0.000040260195,0.0008541529],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99726164,0.00011161895,0.0008854408,0.00016245373,0.0012548813,0.00032396102],"domain_scores_gemma":[0.99789035,0.00011178003,0.00075524946,0.00036852172,0.00060304167,0.0002710625],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018289104,0.0002020366,0.0004448905,0.00007442556,0.000069162656,0.0000067643577,0.00041165814,0.00004292419,0.00014986777],"category_scores_gemma":[0.0024689455,0.000092800525,0.00024596284,0.00020844994,0.00057729677,0.00008059551,0.00020759432,0.00055300497,0.000014522338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009864455,0.00019216294,0.005044757,0.0005668348,0.00020209796,0.00021000154,0.0005094823,0.0000019685929,0.98577833,0.000002848522,0.0022109698,0.004294118],"study_design_scores_gemma":[0.00838324,0.00082217396,0.01502816,0.005643325,0.00014835049,0.0012043933,0.00043531932,0.00000216184,0.9234613,0.000012637794,0.044716813,0.00014210085],"about_ca_topic_score_codex":0.0000031221286,"about_ca_topic_score_gemma":1.1121611e-7,"teacher_disagreement_score":0.062316988,"about_ca_system_score_codex":0.00013259983,"about_ca_system_score_gemma":0.00027174165,"threshold_uncertainty_score":0.37842953},"labels":[],"label_agreement":null},{"id":"W2346898961","doi":"10.1016/j.ejmech.2016.05.011","title":"A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives","year":2016,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada Research Chairs; University of New Brunswick; University of Toronto","funders":"European Commission","keywords":"Chemistry; Pyrazole; Cannabinoid receptor; Antagonist; Stereochemistry; Cannabinoid; Chemical synthesis; Receptor; Ring (chemistry); In vitro; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.027874278019970427,"score_gpt":0.3010389732073935,"score_spread":0.27316469518742303,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2346898961","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0012717239,0.98504186,0.000028443235,0.0075969263,0.00014812678,0.00088214164,0.00008841239,0.000007571631,0.00493479],"genre_scores_gemma":[0.0049171876,0.9928244,0.00013734247,0.00027519933,0.0010098346,0.000039984643,0.0000070565106,0.00009784997,0.00069119444],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.993632,0.001769302,0.0021434631,0.00045320907,0.0015422166,0.00045976453],"domain_scores_gemma":[0.99499166,0.0010911074,0.0018507667,0.0009605954,0.0007060287,0.0003998411],"candidate_categories":["metaresearch","sts"],"consensus_categories":[],"category_scores_codex":[0.0065480806,0.00060651853,0.0030261918,0.00009890836,0.00019850822,0.00003474116,0.0010748708,0.00015653188,0.00035261363],"category_scores_gemma":[0.0086306855,0.00022623081,0.0010292457,0.00048763046,0.0043754326,0.000077738674,0.00043157802,0.0018648948,0.000002029477],"study_design_candidate":"systematic_review","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089128676,0.00035761084,0.000054657572,0.38973913,0.0017154681,0.00021602851,0.00073158304,1.2755224e-7,0.004596196,0.00023019128,0.0353613,0.56610644],"study_design_scores_gemma":[0.002102267,0.0003556658,0.00023419253,0.32455018,0.0044697435,0.004772111,0.0006890293,0.0000053936883,0.0018115165,0.000015816671,0.66060436,0.000389733],"about_ca_topic_score_codex":0.0000052822625,"about_ca_topic_score_gemma":1.4036218e-7,"teacher_disagreement_score":0.62524307,"about_ca_system_score_codex":0.00010007065,"about_ca_system_score_gemma":0.00092109654,"threshold_uncertainty_score":0.99972004},"labels":[],"label_agreement":null},{"id":"W2346942963","doi":"10.1016/j.ejmech.2016.05.004","title":"5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Welch Foundation; National Science Foundation","keywords":"Amaryllidaceae Alkaloids; Chemistry; Drug discovery; Cancer cell; Cancer; Drug resistance; Pharmacology; Alkaloid; Stereochemistry; Biology; Medicine; Biochemistry; Internal medicine","score_opus":0.013051552812221711,"score_gpt":0.21735401165151935,"score_spread":0.20430245883929765,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2346942963","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9863835,0.0022265834,0.0002576922,0.0010440274,0.0001767635,0.00005416113,0.000105520674,0.000022090968,0.009729669],"genre_scores_gemma":[0.995563,0.0009000389,0.000051641913,0.00004267864,0.0015396151,0.0000035916505,0.000002111248,0.00007891308,0.0018184265],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9971679,0.00009373595,0.00094290986,0.00035644337,0.0009955588,0.0004434556],"domain_scores_gemma":[0.9970105,0.000499866,0.0014103138,0.0005706176,0.00022578445,0.00028286377],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011076565,0.00040407715,0.00069511065,0.000037198475,0.00012671713,0.000057407076,0.000895593,0.00007005027,0.00013318172],"category_scores_gemma":[0.0002279098,0.00019098674,0.00025759626,0.00018871522,0.0005344263,0.00024187805,0.00015724525,0.00065318967,0.0000024711123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00077069947,0.00021717594,0.00045379146,0.00061539665,0.00022422263,0.00020094047,0.00013593378,0.000053270047,0.99145776,0.0000027844128,0.0005170365,0.005350987],"study_design_scores_gemma":[0.0023530219,0.0000595449,0.00034888263,0.005764205,0.00015981581,0.00012169417,0.0005059151,0.000025301719,0.9857333,0.0000015153639,0.004633397,0.00029343294],"about_ca_topic_score_codex":0.000041760264,"about_ca_topic_score_gemma":0.0000025108345,"teacher_disagreement_score":0.009179492,"about_ca_system_score_codex":0.00022079764,"about_ca_system_score_gemma":0.0002022983,"threshold_uncertainty_score":0.77882135},"labels":[],"label_agreement":null},{"id":"W2416222571","doi":"10.1016/j.ejmech.2016.01.045","title":"Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Science Foundation of Liaoning Province; National Natural Science Foundation of China","keywords":"Gefitinib; Chemistry; Epidermal growth factor receptor; Moiety; Quinazoline; EGFR inhibitors; Potency; Cell culture; Structure–activity relationship; IC50; Stereochemistry; Mutant; Pharmacology; In vitro; Receptor; Biochemistry; Biology","score_opus":0.0110967368950739,"score_gpt":0.2702799521043617,"score_spread":0.2591832152092878,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2416222571","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9801372,0.00038294893,0.0063888677,0.0018131459,0.00015002243,0.00012651047,0.000010085237,0.0000319477,0.01095927],"genre_scores_gemma":[0.9940171,0.0002180918,0.0024134193,0.00021451092,0.0015820147,0.000001892793,0.000009214595,0.000055585053,0.0014881382],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983504,0.00006051528,0.00044629193,0.00028245672,0.0005787033,0.0002816329],"domain_scores_gemma":[0.99816257,0.0000667594,0.00054391805,0.0002709492,0.0004821533,0.0004736484],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003700649,0.00028254098,0.00040782508,0.000058629037,0.00010496817,0.000019378362,0.00017111817,0.000046671143,0.00006450301],"category_scores_gemma":[0.00014828019,0.00015413192,0.00011769972,0.00015165388,0.00016482337,0.00023151691,0.00003850456,0.00037614832,0.000007457518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001285209,0.0005826947,0.0004900971,0.000121773846,0.00020066206,0.000757075,0.0006265225,0.000018671248,0.9659225,5.214839e-7,0.00014501953,0.029849274],"study_design_scores_gemma":[0.009027323,0.0018078161,0.010999803,0.0019908098,0.00037871316,0.0010455507,0.0009459241,0.0000066516795,0.9728081,0.0000017771987,0.0007788319,0.00020866592],"about_ca_topic_score_codex":0.000005693487,"about_ca_topic_score_gemma":0.0000011281636,"teacher_disagreement_score":0.029640608,"about_ca_system_score_codex":0.00022794218,"about_ca_system_score_gemma":0.00040470247,"threshold_uncertainty_score":0.6285317},"labels":[],"label_agreement":null},{"id":"W2506776793","doi":"10.1016/j.ejmech.2016.07.078","title":"Bridging computational modeling with amino acid replacements to investigate GHS-R1a-peptidomimetic recognition","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University; Lawson Health Research Institute","funders":"","keywords":"Peptidomimetic; Chemistry; Docking (animal); Ghrelin; G protein-coupled receptor; Molecular mechanics; Homology modeling; Stereochemistry; Receptor; Agonist; Ligand (biochemistry); Molecular model; Binding site; Molecular dynamics; Biophysics; Biochemistry; Computational chemistry; Peptide; Biology","score_opus":0.03815599548495353,"score_gpt":0.24395667983069608,"score_spread":0.20580068434574256,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2506776793","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90257293,0.00001749648,0.09199111,0.0016911667,0.000078180834,0.000053671512,0.0000041806434,0.000020118807,0.0035711613],"genre_scores_gemma":[0.9948122,0.00001444272,0.0034980336,0.00086605496,0.00048443157,4.9284e-7,0.0000020087398,0.000023525366,0.0002988416],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982178,0.00015794921,0.00049158686,0.00024640936,0.0006861973,0.00020001119],"domain_scores_gemma":[0.99889404,0.000084175736,0.00036074079,0.0001410367,0.00019718305,0.00032284978],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008404512,0.00014609165,0.00018279262,0.00007607512,0.00010508512,0.000034836423,0.00024832078,0.000017783908,0.00015350059],"category_scores_gemma":[0.0006372852,0.0000958813,0.00005322312,0.00015307605,0.00011103675,0.00020880392,0.000048523805,0.00018494218,0.00009135339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039041988,0.000037963273,0.0002568947,0.000032925192,0.000012982928,0.0003492095,0.00016483857,0.0039803945,0.97939456,0.000004307513,0.000524104,0.014851405],"study_design_scores_gemma":[0.0028318895,0.00040850468,0.0009931208,0.0017470059,0.000044526492,0.0014503275,0.00007216876,0.004163223,0.98726606,0.00023044251,0.00055057066,0.0002421464],"about_ca_topic_score_codex":4.7593252e-7,"about_ca_topic_score_gemma":6.5752005e-8,"teacher_disagreement_score":0.09223926,"about_ca_system_score_codex":0.000064950305,"about_ca_system_score_gemma":0.00007732446,"threshold_uncertainty_score":0.3909926},"labels":[],"label_agreement":null},{"id":"W2512843239","doi":"10.1016/j.ejmech.2016.08.002","title":"Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Drugs for Neglected Diseases initiative; School of Medicine, New York University; York University; NorthShore University HealthSystem; Bill and Melinda Gates Foundation","keywords":"Chemistry; Lipophilicity; Stereochemistry; Prodrug; In vivo; Moiety; In vitro; Structure–activity relationship; Potency; Trypanosoma brucei rhodesiense; African trypanosomiasis; IC50; Biochemistry; Trypanosoma brucei; Trypanosomiasis; Virology; Biology","score_opus":0.015751555934720177,"score_gpt":0.25193275572534624,"score_spread":0.23618119979062607,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2512843239","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97793096,0.00049401965,0.0023994248,0.0121269785,0.000029732973,0.00012947459,0.000012222265,0.00002689923,0.0068502687],"genre_scores_gemma":[0.9974958,0.0001801143,0.00073737034,0.00012690568,0.00065641484,0.0000014205953,0.0000015369815,0.000033191933,0.0007672976],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983505,0.000108279695,0.00034803257,0.00021246621,0.0006517778,0.0003289377],"domain_scores_gemma":[0.9984829,0.00013243788,0.00030349824,0.0002934251,0.00023717113,0.0005506013],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017345262,0.000189995,0.0003615138,0.0000957992,0.000089695095,0.000029061757,0.00019209151,0.000033631364,0.00023936747],"category_scores_gemma":[0.0004958608,0.00010005367,0.00008944856,0.0001730413,0.00052493805,0.00014896483,0.000043721247,0.00042035512,0.000014027971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018827077,0.0001500977,0.011232754,0.00016247894,0.0001039329,0.0009878285,0.000020407184,5.233326e-7,0.96406084,0.0000069129705,0.0008971918,0.020494321],"study_design_scores_gemma":[0.006699123,0.0017024117,0.47526604,0.0011623411,0.00013285276,0.0047003836,0.00008408958,0.000010611286,0.504263,0.000018499162,0.005800357,0.00016031122],"about_ca_topic_score_codex":0.0000027439567,"about_ca_topic_score_gemma":7.8764543e-7,"teacher_disagreement_score":0.4640333,"about_ca_system_score_codex":0.00008690947,"about_ca_system_score_gemma":0.0003719156,"threshold_uncertainty_score":0.40800706},"labels":[],"label_agreement":null},{"id":"W2520893324","doi":"10.1016/j.ejmech.2016.09.018","title":"Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Simon Fraser University; Genome British Columbia; Leading Edge Endowment Fund; Government of the United Kingdom; Merck Canada; Genome Canada","keywords":"Chemistry; Antimicrobial; Pyruvate kinase; Kinase; Combinatorial chemistry; Pharmacology; Stereochemistry; Biochemistry; Enzyme; Organic chemistry; Glycolysis","score_opus":0.02975184282217379,"score_gpt":0.24360699685490805,"score_spread":0.21385515403273425,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2520893324","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9931037,0.00023074557,0.00009166072,0.005699092,0.00019658411,0.00008073198,0.00002081301,0.0000036320705,0.0005730379],"genre_scores_gemma":[0.9982897,0.000158361,0.00028976233,0.00015376361,0.00087824534,3.5387913e-8,0.0000030666183,0.000017068993,0.00020999198],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983914,0.000094714065,0.0008520739,0.00011982256,0.00042163176,0.00012038422],"domain_scores_gemma":[0.997917,0.00005217812,0.0012026486,0.0001975018,0.00053184,0.0000988159],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012600194,0.00013185368,0.00037568054,0.000050584644,0.000019752499,0.0000026145367,0.00020589771,0.000047715737,0.00021008696],"category_scores_gemma":[0.00057591137,0.00006375065,0.00015794774,0.00014803624,0.0005460847,0.000060674833,0.00004383547,0.00021364239,0.0000014750038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003888587,0.0000780181,0.0009924643,0.00032012322,0.00008810168,0.000020698948,0.00044285497,0.0000011149376,0.983602,0.0000014668364,0.004187038,0.0098773],"study_design_scores_gemma":[0.002032011,0.00026491148,0.009583267,0.0025922963,0.00018017364,0.000076015574,0.00018665043,0.0000017752005,0.9838121,0.0000028626655,0.0012036159,0.00006435012],"about_ca_topic_score_codex":0.0000063479156,"about_ca_topic_score_gemma":1.2507031e-7,"teacher_disagreement_score":0.009812949,"about_ca_system_score_codex":0.000033773886,"about_ca_system_score_gemma":0.00013347295,"threshold_uncertainty_score":0.25996763},"labels":[],"label_agreement":null},{"id":"W2553710662","doi":"10.1016/j.ejmech.2016.11.021","title":"Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"McGill University","keywords":"Chemistry; Lead compound; Förster resonance energy transfer; Isophthalic acid; IC50; EC50; Stereochemistry; Enzyme; Structure–activity relationship; Drug; Fluorescence; Combinatorial chemistry; In vitro; Biochemistry; Pharmacology; Organic chemistry","score_opus":0.025251454891004204,"score_gpt":0.27298505966371195,"score_spread":0.24773360477270776,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2553710662","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.19590601,0.0025303818,0.79803383,0.0030436006,0.00013785325,0.000084129264,0.000023222834,0.000014530586,0.00022640904],"genre_scores_gemma":[0.94764674,0.00008622748,0.05189872,0.00006490328,0.00023264701,0.0000010395177,0.0000012333912,0.0000143913885,0.000054098287],"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9980495,0.00038026558,0.0006196355,0.00025249363,0.0005100818,0.00018803123],"domain_scores_gemma":[0.9970512,0.0014876465,0.00059235684,0.00026920676,0.00029177257,0.00030785205],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0025657008,0.00016210337,0.00038587075,0.00018094752,0.000058826474,0.000042244825,0.00061843777,0.000015445361,0.000015586924],"category_scores_gemma":[0.00081156986,0.000106456406,0.00020992933,0.00035251238,0.00014065232,0.00026644056,0.00013689685,0.00009827879,0.0000012972866],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018154093,0.0005541721,0.008097499,0.00044778213,0.006485332,0.0011141024,0.0020151779,0.015446312,0.19566838,0.00018221393,0.010141908,0.7580317],"study_design_scores_gemma":[0.0043076775,0.0005619613,0.05255077,0.0029102424,0.008052615,0.00035431093,0.00044712552,0.098810144,0.82698506,0.0021952663,0.0017746964,0.0010501315],"about_ca_topic_score_codex":0.00000204129,"about_ca_topic_score_gemma":1.16676006e-7,"teacher_disagreement_score":0.75698155,"about_ca_system_score_codex":0.00004289253,"about_ca_system_score_gemma":0.00020066083,"threshold_uncertainty_score":0.4341166},"labels":[],"label_agreement":null},{"id":"W2555147185","doi":"10.1016/j.ejmech.2016.10.041","title":"Synthesis of copper and zinc 2-(pyridin-2-yl)imidazo[1,2-a]pyridine complexes and their potential anticancer activity","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Universiteit Stellenbosch; Medical Research Council; University of the Witwatersrand, Johannesburg; South African Medical Research Council; National Research Foundation; McGill University","keywords":"Chemistry; Ethidium bromide; Acridine orange; Copper; Pyridine; Bromide; Zinc; Amine gas treating; Stereochemistry; Medicinal chemistry; Apoptosis; Organic chemistry; DNA; Biochemistry","score_opus":0.024764354012871477,"score_gpt":0.23722056361682275,"score_spread":0.21245620960395128,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2555147185","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9890967,0.0029772783,0.00018022223,0.0030146765,0.00008519907,0.000065009095,0.000018544619,0.000010433044,0.0045519643],"genre_scores_gemma":[0.99751884,0.0014672341,0.00017088772,0.00009433602,0.0005738358,6.3501136e-7,4.4715523e-7,0.000033671855,0.00014011045],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983937,0.0002076822,0.00055813603,0.00021734368,0.00039971978,0.00022342213],"domain_scores_gemma":[0.9984411,0.0003253169,0.00047002587,0.00023367017,0.00022645466,0.00030341817],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012710182,0.00024155139,0.0007550758,0.000051967767,0.00007282192,0.00001575928,0.00016231411,0.000041034884,0.0003421255],"category_scores_gemma":[0.0006187843,0.00012356331,0.00014455894,0.00006440881,0.00065795856,0.000107661726,0.0001032143,0.00024021749,0.0000028658596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011872208,0.000080495716,0.0015753699,0.00037984745,0.00019409516,0.00012044992,0.0001118393,8.199226e-7,0.9395521,0.0000049342148,0.00070703373,0.056085758],"study_design_scores_gemma":[0.001579698,0.00045834028,0.027953831,0.0018682758,0.00028343202,0.0023255565,0.00025715877,0.00004975647,0.96127045,0.000024407624,0.0037691896,0.00015992572],"about_ca_topic_score_codex":0.0000047628523,"about_ca_topic_score_gemma":2.2958656e-7,"teacher_disagreement_score":0.05592583,"about_ca_system_score_codex":0.000027668499,"about_ca_system_score_gemma":0.00007496791,"threshold_uncertainty_score":0.5038765},"labels":[],"label_agreement":null},{"id":"W2559716120","doi":"10.1016/j.ejmech.2016.12.005","title":"2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Ontario Mental Health Foundation; Canada Foundation for Innovation","keywords":"Chemistry; Cholinesterase; Antioxidant; Structure–activity relationship; Biochemistry; Pharmacology; Stereochemistry; In vitro","score_opus":0.03986360962242318,"score_gpt":0.27612997658000193,"score_spread":0.23626636695757874,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2559716120","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9960465,0.0023670092,0.00010285715,0.0011999359,0.00007531291,0.00013331954,0.000006440606,0.000019606316,0.000049035127],"genre_scores_gemma":[0.9983854,0.00030621517,0.00031150927,0.00016025244,0.00066190993,0.0000013496916,0.0000058770997,0.000026577374,0.00014088956],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985608,0.00011719371,0.00050481135,0.00025229336,0.0004094162,0.00015551264],"domain_scores_gemma":[0.99865294,0.000092550596,0.00040084377,0.00012211148,0.0004574441,0.0002741096],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033883436,0.00024361454,0.0003517347,0.00009077499,0.00013980904,0.000026665315,0.000033885306,0.000033547272,0.000010548897],"category_scores_gemma":[0.00077428913,0.00013023058,0.00003756282,0.000119619275,0.00031331222,0.0002976431,0.00003795774,0.00022574849,0.0000013399505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016613648,0.00012957824,0.030339489,0.0005016232,0.00014544181,0.0016420238,0.0014285968,0.0000032227042,0.9535796,0.0000026479672,0.000091014736,0.010475402],"study_design_scores_gemma":[0.005157788,0.0004617495,0.11782839,0.004705402,0.00023777838,0.004929444,0.0006592145,0.000003764529,0.8653843,0.0000089584855,0.00040556828,0.0002176841],"about_ca_topic_score_codex":9.820354e-7,"about_ca_topic_score_gemma":0.0000015805022,"teacher_disagreement_score":0.08819534,"about_ca_system_score_codex":0.0000642164,"about_ca_system_score_gemma":0.00018958094,"threshold_uncertainty_score":0.53106487},"labels":[],"label_agreement":null},{"id":"W2586278287","doi":"10.1016/j.ejmech.2017.02.006","title":"Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Serine protease; Serine; Amino acid; Biochemistry; Protease; Enzyme","score_opus":0.00941736685220878,"score_gpt":0.23569820659599952,"score_spread":0.22628083974379073,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2586278287","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9786913,0.0010121944,0.00008502763,0.00232979,0.00016658408,0.000065108616,0.0000018018652,0.000008408889,0.017639795],"genre_scores_gemma":[0.9984824,0.000085700594,0.00028449978,0.00008917577,0.0006555799,1.762658e-7,0.000001597875,0.000024476029,0.00037636224],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985863,0.00007925597,0.00046612785,0.00012020916,0.00055090635,0.00019721314],"domain_scores_gemma":[0.998204,0.000043612312,0.0009289724,0.00036909393,0.00027734964,0.00017697166],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010773,0.00015511454,0.00033853695,0.000029528454,0.00023007703,0.000023751187,0.00032779088,0.000049544262,0.000047059828],"category_scores_gemma":[0.0005573326,0.000079413534,0.00013482691,0.00007988,0.0004309698,0.00008831445,0.000059544687,0.00093064323,0.000002189776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0031352292,0.00047499748,0.12372287,0.0012407022,0.001053807,0.006068362,0.0026858775,0.0001790326,0.7822413,0.000014830522,0.008410612,0.07077238],"study_design_scores_gemma":[0.0188932,0.0038402108,0.41573268,0.008164481,0.0018918547,0.023744326,0.007451971,0.00071980874,0.5072051,0.000052654064,0.01162486,0.0006788435],"about_ca_topic_score_codex":0.000007796271,"about_ca_topic_score_gemma":3.296216e-7,"teacher_disagreement_score":0.2920098,"about_ca_system_score_codex":0.000037754897,"about_ca_system_score_gemma":0.00014755111,"threshold_uncertainty_score":0.40432334},"labels":[],"label_agreement":null},{"id":"W2589639399","doi":"10.1016/j.ejmech.2017.02.048","title":"Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Key Research and Development Program of China; Science and Technology Commission of Shanghai Municipality; Chinese Academy of Sciences; Fondation Jean-Louis Lévesque; Juvenile Diabetes Research Foundation United States of America","keywords":"Chemistry; Apoptosis; Kinase; Islet; Programmed cell death; Drug discovery; IC50; Benzofuran; Biochemistry; Pharmacology; Biology; Stereochemistry; Diabetes mellitus; In vitro; Endocrinology","score_opus":0.029628728317767257,"score_gpt":0.2537783200895458,"score_spread":0.22414959177177857,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2589639399","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9698168,0.00059814466,0.00073003327,0.001464678,0.00038499647,0.00012724484,0.000026682452,0.000014305865,0.026837105],"genre_scores_gemma":[0.99522233,0.00014928008,0.0012693385,0.00028516134,0.00168425,0.0000012978076,0.000011012785,0.000041674113,0.0013356796],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99787873,0.00008118359,0.0007335264,0.00023521598,0.00083149964,0.00023985254],"domain_scores_gemma":[0.99732953,0.00017860254,0.0014263095,0.0005472269,0.0002319259,0.0002864179],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00080651115,0.00025609363,0.0007214118,0.000067358385,0.00014063825,0.000062838015,0.000406783,0.000066942426,0.0003359032],"category_scores_gemma":[0.0016407039,0.00019314984,0.00026525522,0.00006962625,0.00043745458,0.00029211724,0.000103056125,0.000582093,0.000018667386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000703117,0.00028337873,0.0032240278,0.00025852953,0.00033784076,0.000109752065,0.0003607076,0.0000013456764,0.99119556,0.0000025971106,0.0016001394,0.0019230229],"study_design_scores_gemma":[0.0047334903,0.00053783506,0.01549037,0.0027797436,0.00038410764,0.000117938216,0.00091906625,0.000006444468,0.97356707,0.000032200303,0.0012668326,0.00016487911],"about_ca_topic_score_codex":0.000029710385,"about_ca_topic_score_gemma":9.556328e-8,"teacher_disagreement_score":0.025501426,"about_ca_system_score_codex":0.000053683216,"about_ca_system_score_gemma":0.00018390513,"threshold_uncertainty_score":0.7876422},"labels":[],"label_agreement":null},{"id":"W2596552143","doi":"10.1016/j.ejmech.2017.03.029","title":"Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved cis-platin","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canada Foundation for Innovation; Institut national de la recherche scientifique; Armand-Frappier Foundation","keywords":"Lipophilicity; Chemistry; Cytotoxicity; Ruthenium; Cancer cell; Structure–activity relationship; In vivo; Stereochemistry; Zebrafish; In vitro; Biological activity; Cell growth; Cancer; Cell culture; Biochemistry; Biology","score_opus":0.06387411800052878,"score_gpt":0.3204166605592986,"score_spread":0.25654254255876985,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2596552143","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9953384,0.0000782422,0.000049613933,0.0014680884,0.00004504399,0.00065883185,0.000015604852,0.0000048519114,0.002341324],"genre_scores_gemma":[0.999111,0.000022290866,0.0003012143,0.00022922545,0.00018103146,0.000011668609,0.0000010976353,0.000022294658,0.00012016888],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99715966,0.00071046595,0.0010595983,0.0003133603,0.0005228388,0.0002340653],"domain_scores_gemma":[0.99782616,0.00039510967,0.0009492153,0.0004520086,0.00021391276,0.0001636161],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0037455827,0.00023903587,0.0008521941,0.00010276777,0.0001830973,0.00004743606,0.00029973243,0.000055261837,0.000036696027],"category_scores_gemma":[0.0016881567,0.00015036858,0.000075517055,0.00014915463,0.0002693292,0.00016450537,0.00013399811,0.00086342776,5.731097e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.011643828,0.00080129976,0.098846145,0.000121777404,0.000053814852,0.00017537031,0.004331146,0.00020653346,0.8834917,5.768196e-7,0.00006617532,0.00026161212],"study_design_scores_gemma":[0.004769581,0.0021615047,0.3927796,0.0012222014,0.000080624755,0.00007347977,0.0013015878,0.0007432858,0.59664553,0.00001142036,0.000029041472,0.0001821394],"about_ca_topic_score_codex":0.00013509071,"about_ca_topic_score_gemma":0.0005471767,"teacher_disagreement_score":0.29393345,"about_ca_system_score_codex":0.00008940298,"about_ca_system_score_gemma":0.00022542138,"threshold_uncertainty_score":0.6131853},"labels":[],"label_agreement":null},{"id":"W2605187148","doi":"10.1016/j.ejmech.2017.03.080","title":"Synthesis of new N3- substituted dihydropyrimidine derivatives as L-/T- type calcium channel blockers","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Multicomponent Synthesis of Heterocycles","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; College of Pharmacy; Ministry of Higher Education; South Dakota State University","keywords":"Chemistry; DHPS; Pharmacology; Calcium channel; Calcium; Combinatorial chemistry; Organic chemistry","score_opus":0.04585539591963771,"score_gpt":0.2890312922427588,"score_spread":0.2431758963231211,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2605187148","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9788234,0.0007509279,0.00007032635,0.0012900969,0.00021025435,0.000029513474,0.000008204958,0.000026726737,0.018790519],"genre_scores_gemma":[0.99729335,0.00019232763,0.0006839852,0.000019182107,0.0012951954,4.783558e-7,0.0000037995103,0.00006694685,0.0004447534],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9975637,0.000071009126,0.00097371533,0.000278222,0.0007630564,0.0003502558],"domain_scores_gemma":[0.9962904,0.0002536661,0.0019191025,0.0008122235,0.00022607794,0.00049856986],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006861274,0.0003486238,0.0006909563,0.00006471764,0.00021210757,0.000055313092,0.0015579144,0.00008842238,0.0014145152],"category_scores_gemma":[0.0031693669,0.00029446385,0.00025574485,0.00003709221,0.0004631988,0.00020797816,0.00019342892,0.0005361181,0.000036367917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00057663914,0.00013506218,0.00075788517,0.00035654803,0.00029159186,0.00072217826,0.000260451,0.00002245675,0.9925034,0.0000018157637,0.0011761804,0.0031958155],"study_design_scores_gemma":[0.0011895244,0.00003612496,0.00178274,0.001707256,0.00023140262,0.00039736685,0.00045818186,0.00007915997,0.99188244,0.000021320582,0.0019479598,0.00026651405],"about_ca_topic_score_codex":0.000038856244,"about_ca_topic_score_gemma":4.3322655e-7,"teacher_disagreement_score":0.0184699,"about_ca_system_score_codex":0.00007076022,"about_ca_system_score_gemma":0.00016476556,"threshold_uncertainty_score":0.99995077},"labels":[],"label_agreement":null},{"id":"W2605453051","doi":"10.1016/j.ejmech.2017.04.042","title":"Inhibitors of cytochrome P450 (CYP) 1B1","year":2017,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Fonds de Recherche du Québec - Santé","keywords":"CYP1B1; Cytochrome P450; Chemistry; Hydroxylation; Enzyme; Carcinogenesis; Carcinogen; Biochemistry; Cytochrome; Unspecific monooxygenase; CYP1A2; Gene","score_opus":0.34223543808148477,"score_gpt":0.5229245309550812,"score_spread":0.1806890928735964,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2605453051","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00067441206,0.96044177,0.000016020711,0.00007612767,0.0018775132,0.00018473295,0.00010164985,0.0000130903845,0.036614656],"genre_scores_gemma":[0.0025192325,0.98946637,0.00010725821,0.000120644596,0.006333616,0.000002563403,0.000023598039,0.000108483066,0.0013182278],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99507785,0.0012092424,0.002285513,0.00032970018,0.00062247104,0.00047522073],"domain_scores_gemma":[0.99341,0.00033659922,0.004633927,0.0005177153,0.00036557147,0.00073620793],"candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004567054,0.0006191148,0.0025648992,0.00018358571,0.00017054321,0.000025032063,0.0018498963,0.00036218477,0.0013878825],"category_scores_gemma":[0.0005790532,0.00047764686,0.0010999274,0.00014750524,0.000603393,0.00007642364,0.00028330425,0.0033410771,0.000088205576],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010107818,0.00021434228,0.0000049709915,0.010743194,0.0010129807,0.002396238,0.00014812905,0.000004967274,0.009853729,0.00000343065,0.012011476,0.96350545],"study_design_scores_gemma":[0.001560818,0.00012423094,0.000011232833,0.0068943934,0.0038129755,0.002067757,0.00002702501,0.000002747949,0.005145122,0.000009130376,0.9799792,0.00036535168],"about_ca_topic_score_codex":7.1287235e-7,"about_ca_topic_score_gemma":4.714358e-8,"teacher_disagreement_score":0.96796775,"about_ca_system_score_codex":0.00007942516,"about_ca_system_score_gemma":0.00072550384,"threshold_uncertainty_score":0.99976754},"labels":[],"label_agreement":null},{"id":"W2620324926","doi":"10.1016/j.ejmech.2017.05.052","title":"Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa; Health Sciences North","funders":"Natural Sciences and Engineering Research Council of Canada; Northern Ontario Heritage Fund Corporation","keywords":"Chemistry; Cancer; Cancer cell; Apoptosis; Cancer research; Stereochemistry; Biochemistry; Biology; Genetics","score_opus":0.04282701450296352,"score_gpt":0.26397176466818356,"score_spread":0.22114475016522003,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2620324926","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9976584,0.00040755473,0.0009354299,0.00023726016,0.000062591316,0.00005405604,0.000047582726,0.0000025114757,0.00059464783],"genre_scores_gemma":[0.9979834,0.0014570063,0.0001850455,0.000011060357,0.00024552285,0.0000015538892,0.0000034697778,0.000012934191,0.00010000952],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99884975,0.00006754306,0.00048844604,0.00017673046,0.00030589473,0.0001116509],"domain_scores_gemma":[0.9976506,0.0002001803,0.001697509,0.00020866365,0.00017905708,0.00006393889],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005883062,0.00016428424,0.00041128858,0.000017670149,0.00009350896,0.000023898538,0.00021439094,0.00006942134,0.00034736266],"category_scores_gemma":[0.00015715804,0.0000998753,0.00006051106,0.000030375608,0.00040011774,0.00018965785,0.000091101574,0.00015474793,5.4543786e-8],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034564725,0.00007971745,0.006136275,0.00040182305,0.00010565744,0.0000016877071,0.00021444837,0.000006821085,0.9767621,0.0000021187589,0.000021198704,0.015922496],"study_design_scores_gemma":[0.0005851091,0.000041497115,0.30301157,0.0007140381,0.00015511323,0.000020612786,0.000052664574,0.00016708084,0.69509625,0.000012547127,0.00007185533,0.00007164394],"about_ca_topic_score_codex":0.000048527247,"about_ca_topic_score_gemma":0.000001947053,"teacher_disagreement_score":0.2968753,"about_ca_system_score_codex":0.00001987101,"about_ca_system_score_gemma":0.000035835405,"threshold_uncertainty_score":0.40727964},"labels":[],"label_agreement":null},{"id":"W2622009965","doi":"10.1016/j.ejmech.2017.06.019","title":"Covalent inhibitors design and discovery","year":2017,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":313,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Covalent bond; Chemistry; Drug discovery; Combinatorial chemistry; Computational biology; Biochemical engineering; Nanotechnology; Biochemistry; Organic chemistry; Engineering; Biology; Materials science","score_opus":0.11701220750222463,"score_gpt":0.3488963609730948,"score_spread":0.23188415347087016,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2622009965","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00010760091,0.9760778,0.00040464825,0.0000833321,0.00011812375,0.00006951634,0.000032247328,0.000020661133,0.023086105],"genre_scores_gemma":[0.00045374694,0.9904278,0.00030599575,0.000013291603,0.0034324862,0.0000055899054,0.000040606057,0.00009712174,0.0052233906],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9972684,0.00010627714,0.0014130517,0.00040189986,0.00050890015,0.00030149458],"domain_scores_gemma":[0.9956293,0.00035633275,0.0027199783,0.0007642331,0.000115818206,0.0004143339],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0012964832,0.0005531048,0.0015372063,0.00003978603,0.00021469346,0.00017192782,0.0011099788,0.00019295403,0.00031157967],"category_scores_gemma":[0.0005534963,0.00042843597,0.0005596546,0.000062234925,0.0003868153,0.0001469038,0.00023246661,0.0015557976,0.000018667872],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00003457665,0.00011049641,0.000001773489,0.028522229,0.00037213683,0.0014125993,0.000054892487,0.000001267345,0.0032399725,0.000004708442,0.008162564,0.9580828],"study_design_scores_gemma":[0.00047641277,0.000024360446,3.38543e-7,0.025716428,0.0011577833,0.0044274596,0.000056419653,9.935203e-7,0.005705942,0.000017391932,0.9620501,0.00036636734],"about_ca_topic_score_codex":5.035078e-7,"about_ca_topic_score_gemma":1.2120483e-8,"teacher_disagreement_score":0.9577164,"about_ca_system_score_codex":0.00012138681,"about_ca_system_score_gemma":0.0003924633,"threshold_uncertainty_score":0.9998167},"labels":[],"label_agreement":null},{"id":"W2730699232","doi":"10.1016/j.ejmech.2017.06.058","title":"Ciprofloxacin-nitroxide hybrids with potential for biofilm control","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; Queensland University of Technology; Asian Office of Aerospace Research and Development; Australian Research Council; Fundación Ramón Areces","keywords":"Chemistry; Biofilm; Ciprofloxacin; Nitroxide mediated radical polymerization; Antimicrobial; Microbiology; Combinatorial chemistry; Antibiotics; Bacteria; Biochemistry; Organic chemistry; Biology; Polymer; Monomer","score_opus":0.007744478040259424,"score_gpt":0.22628447573613641,"score_spread":0.21853999769587698,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2730699232","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9911227,0.00031291877,0.0042925132,0.00086096703,0.000349752,0.000084856176,0.000024412064,0.0000047944354,0.0029470841],"genre_scores_gemma":[0.993937,0.000049819533,0.0017494461,0.0002252444,0.0035145627,6.2201804e-7,0.000018429882,0.000039026567,0.0004658465],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989107,0.00005426971,0.0003653958,0.00020608393,0.00020168947,0.00026185293],"domain_scores_gemma":[0.99844056,0.000009971748,0.00067106064,0.0003926776,0.00028385577,0.00020186116],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00072976644,0.00018495129,0.00025832208,0.000017961906,0.0002404011,0.000080299695,0.00042596343,0.000053129566,0.000022366481],"category_scores_gemma":[0.0002547276,0.00013619874,0.00015702391,0.000013486408,0.00021995425,0.000010332024,0.00005608197,0.00019043685,0.0000022736556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015163664,0.000029347164,0.00025287946,0.000039087732,0.00013040724,0.00026047984,0.000009337068,0.000008847279,0.9922211,0.0000015339042,0.0021968528,0.003333767],"study_design_scores_gemma":[0.00573631,0.0011829882,0.0029066915,0.00017180758,0.00017092722,0.0012773476,0.000083953,0.000021230622,0.9562115,0.0000038565645,0.03199744,0.00023591556],"about_ca_topic_score_codex":0.0000017517243,"about_ca_topic_score_gemma":4.028444e-7,"teacher_disagreement_score":0.03600956,"about_ca_system_score_codex":0.000010804684,"about_ca_system_score_gemma":0.00010693135,"threshold_uncertainty_score":0.55540234},"labels":[],"label_agreement":null},{"id":"W2735575278","doi":"10.1016/j.ejmech.2017.07.017","title":"Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Higher Education Commission, Pakistan; Organisation for the Prohibition of Chemical Weapons; Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Regioselectivity; Docking (animal); Amination; Active site; Stereochemistry; Nucleotide; Combinatorial chemistry; Nucleoside; Chemical synthesis; Trifluoromethyl; Enzyme; Biochemistry; Organic chemistry; In vitro; Catalysis","score_opus":0.026705393032951528,"score_gpt":0.2866637579215197,"score_spread":0.25995836488856816,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2735575278","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98903054,0.008070953,0.000055580225,0.00022927068,0.000095842406,0.000058074856,0.000007817847,0.0000033122844,0.0024485828],"genre_scores_gemma":[0.99815965,0.0006245695,0.00020921072,0.000048287893,0.00088111643,0.0000010181825,0.00001187566,0.000019563278,0.000044720262],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985712,0.00019262667,0.0004842519,0.00021225993,0.00038366814,0.00015594694],"domain_scores_gemma":[0.9981806,0.000049217546,0.0008360116,0.00026452556,0.00051609,0.00015353886],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0020991121,0.0001691508,0.00027806725,0.000032139615,0.00012200476,0.000023024993,0.00034535487,0.000080147154,0.0000924228],"category_scores_gemma":[0.0034456265,0.00013146616,0.00010274795,0.00004411811,0.00028730225,0.000011703261,0.000118794786,0.00020965842,0.0000019796173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00039551902,0.00006495207,0.0018281782,0.000038280366,0.00014345265,0.000106844884,0.00006681077,0.000016112004,0.9854953,0.0000021246653,0.002309626,0.009532761],"study_design_scores_gemma":[0.0012735465,0.00040023657,0.00543043,0.0001932658,0.00018216339,0.0002718215,0.00024756862,0.000028794264,0.99093515,0.000037730708,0.0008567894,0.00014250577],"about_ca_topic_score_codex":0.000008325914,"about_ca_topic_score_gemma":1.0261077e-7,"teacher_disagreement_score":0.0093902545,"about_ca_system_score_codex":0.000015931786,"about_ca_system_score_gemma":0.00013369988,"threshold_uncertainty_score":0.5361034},"labels":[],"label_agreement":null},{"id":"W2738834929","doi":"10.1016/j.ejmech.2017.07.058","title":"Hydroxy-substituted trans -cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Università di Bologna","keywords":"Chemistry; Neuroprotection; Neurotoxicity; GSK-3; Oxidative stress; Context (archaeology); Neurodegeneration; Biochemistry; GSK3B; Mitochondrial permeability transition pore; Amyloid precursor protein; Pharmacology; Stereochemistry; Alzheimer's disease; Kinase; Disease; Internal medicine; Toxicity; Programmed cell death","score_opus":0.05978992845446301,"score_gpt":0.3301771920634738,"score_spread":0.2703872636090108,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2738834929","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9775219,0.008261643,0.00004435604,0.0038377598,0.000088236,0.00021324251,0.000035472134,0.0000065943127,0.009990815],"genre_scores_gemma":[0.9989176,0.00026955176,0.00006710092,0.00022064992,0.00043995405,0.0000030452484,0.000028845332,0.000021671502,0.00003159343],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99781734,0.00019113082,0.0006039332,0.00017822257,0.0009579408,0.0002514214],"domain_scores_gemma":[0.9980523,0.00014103383,0.0005329436,0.00046602273,0.00028564906,0.0005220675],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009600786,0.00019648377,0.00039222575,0.00006218078,0.00016999188,0.00003924061,0.00046745737,0.000028919683,0.00031387302],"category_scores_gemma":[0.0010354257,0.00012171428,0.00024356498,0.00007436198,0.00058963796,0.00021602208,0.000038820453,0.0005121507,0.00001596401],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.05335912,0.014646394,0.36946765,0.0020312811,0.047795117,0.1867501,0.0128845135,0.00009670823,0.14234136,0.00029633864,0.01159669,0.15873471],"study_design_scores_gemma":[0.01672456,0.00087089685,0.944508,0.002077792,0.0023822042,0.0015156333,0.0031669703,0.000085197236,0.026214678,0.00008617143,0.0021111418,0.00025672442],"about_ca_topic_score_codex":0.000014188585,"about_ca_topic_score_gemma":8.285655e-7,"teacher_disagreement_score":0.5750404,"about_ca_system_score_codex":0.00003845093,"about_ca_system_score_gemma":0.00047168433,"threshold_uncertainty_score":0.49633643},"labels":[],"label_agreement":null},{"id":"W2757927998","doi":"10.1016/j.ejmech.2017.09.070","title":"Design, synthesis and immunological evaluation of novel amphiphilic desmuramyl peptides","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Energy; NOSM University; Lakehead University","funders":"Natural Sciences and Engineering Research Council of Canada; Lakehead University","keywords":"Muramyl dipeptide; Chemistry; Muramic acid; Immune system; Peptide; Dipeptide; Amphiphile; Secretion; Biochemistry; Glycoprotein; Moiety; Stereochemistry; In vitro; Cell wall; Immunology; Peptidoglycan; Biology","score_opus":0.06797099220841797,"score_gpt":0.2865033531906085,"score_spread":0.21853236098219053,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2757927998","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9907099,0.005381758,0.0010729657,0.00044956518,0.00014442886,0.000060708342,0.0000011456681,0.0000054202574,0.0021741327],"genre_scores_gemma":[0.99916077,0.00033784937,0.00028987986,0.000011663512,0.00008153157,0.0000010750097,0.0000020568455,0.00000948061,0.000105667954],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985973,0.00052069384,0.00050680496,0.00010492818,0.00013436501,0.00013585536],"domain_scores_gemma":[0.9981427,0.0002677338,0.000936624,0.00026355486,0.0003647989,0.000024561554],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0051702196,0.000116932075,0.00027683738,0.000043819124,0.00019338756,0.000018439843,0.0003655481,0.00007494658,0.00024408757],"category_scores_gemma":[0.003445197,0.00008673474,0.00007091513,0.000021165231,0.00046981007,0.00013060062,0.000070292655,0.00029992635,0.000011008382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005211542,0.000057104622,0.00016091754,0.000025649233,0.00014072978,0.000016930115,0.00018512893,0.000010068945,0.95004433,0.0000048352285,0.00011666962,0.048716474],"study_design_scores_gemma":[0.0022886037,0.00023167003,0.029227458,0.00040588324,0.00026258864,0.0012233324,0.00028870892,0.000028209206,0.9653243,0.00002796177,0.00059747737,0.000093808885],"about_ca_topic_score_codex":0.0000025924319,"about_ca_topic_score_gemma":5.096868e-8,"teacher_disagreement_score":0.048622664,"about_ca_system_score_codex":0.000029116589,"about_ca_system_score_gemma":0.000099788784,"threshold_uncertainty_score":0.41244715},"labels":[],"label_agreement":null},{"id":"W2771172401","doi":"10.1016/j.ejmech.2017.11.097","title":"Design and synthesis of novel quinacrine-[1,3]-thiazinan-4-one hybrids for their anti-breast cancer activity","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences North","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; PI3K/AKT/mTOR pathway; Cancer research; Cancer; Cell culture; Cancer cell; Breast cancer; Prostate cancer; Cell growth; Cancer cell lines; Apoptosis; Biology; Biochemistry; Genetics","score_opus":0.03771487640941538,"score_gpt":0.2818430136049333,"score_spread":0.24412813719551793,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2771172401","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9463082,0.001145771,0.05069038,0.0010732135,0.00018862619,0.00010005556,0.0000799815,0.000002558114,0.0004112068],"genre_scores_gemma":[0.9959736,0.0012808488,0.0017188912,0.0000599826,0.0007804586,0.0000033484782,0.0000014162439,0.000031862397,0.00014962691],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99918944,0.000041976346,0.00026107387,0.00018108588,0.00015491716,0.00017149774],"domain_scores_gemma":[0.9986614,0.00003758231,0.000625496,0.0003190619,0.00023044033,0.00012599508],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008870752,0.00015482728,0.00029382997,0.000017852175,0.000119593366,0.000024558769,0.0003756635,0.00004299273,0.000014496138],"category_scores_gemma":[0.00013917204,0.00012627854,0.00010950133,0.00001493742,0.00017484288,0.000008459767,0.000095206924,0.00013114091,1.0984439e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006261034,0.00012283218,0.00007468484,0.00013322009,0.00016942126,0.000010319905,0.000031871532,0.000012176776,0.96404356,0.0000024827373,0.00022960972,0.034543745],"study_design_scores_gemma":[0.0017282431,0.0002634842,0.0020459862,0.00028906233,0.00013560189,0.00036901477,0.00006716599,0.00007095157,0.9915973,0.00001193792,0.0032848548,0.00013641355],"about_ca_topic_score_codex":0.0000054491666,"about_ca_topic_score_gemma":6.14162e-7,"teacher_disagreement_score":0.049665354,"about_ca_system_score_codex":0.000015299345,"about_ca_system_score_gemma":0.00012406232,"threshold_uncertainty_score":0.5149489},"labels":[],"label_agreement":null},{"id":"W2771994802","doi":"10.1016/j.ejmech.2017.11.073","title":"Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Liver physiology and pathology","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Fundamental Research Funds for the Central Universities; Higher Education Discipline Innovation Project; State Administration of Foreign Experts Affairs; China Pharmaceutical University; National Natural Science Foundation of China; Ministry of Education of the People's Republic of China; National Science Foundation","keywords":"In silico; Virtual screening; Protein kinase domain; Chemistry; Computational biology; Kinase; Drug discovery; Biochemistry; Biology; Mutant","score_opus":0.0643939176359361,"score_gpt":0.3221508971517049,"score_spread":0.2577569795157688,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2771994802","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98835987,0.0004649769,0.0075860443,0.0009242566,0.00027787982,0.00011732627,0.000007117017,0.000004812517,0.0022577252],"genre_scores_gemma":[0.9947552,0.00008761099,0.0034922545,0.00016768168,0.0013637757,0.0000012110526,0.00002301775,0.000009968659,0.00009928935],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9992317,0.00007434386,0.00028756892,0.0001343514,0.00016363212,0.0001084064],"domain_scores_gemma":[0.9989709,0.00007320917,0.00045030905,0.00016900006,0.00023181924,0.0001047119],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015517492,0.00009576296,0.00023119556,0.000023464865,0.00015564727,0.000019090478,0.000121813064,0.000053855205,0.00003847095],"category_scores_gemma":[0.0013970141,0.00006544739,0.00007031047,0.000014895729,0.00029490053,0.00011728084,0.00004469152,0.00022114353,9.48095e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017346042,0.00022939323,0.011504499,0.0001819305,0.00013645018,0.0003262825,0.00030023922,0.00020020318,0.9708046,0.000024440094,0.0012546872,0.013302682],"study_design_scores_gemma":[0.0590623,0.013026439,0.6194981,0.0029666484,0.0029322584,0.014695696,0.0018153222,0.006559504,0.2715633,0.0006148704,0.0063283956,0.00093721325],"about_ca_topic_score_codex":4.6886566e-7,"about_ca_topic_score_gemma":2.858163e-8,"teacher_disagreement_score":0.6992413,"about_ca_system_score_codex":0.000023376124,"about_ca_system_score_gemma":0.00007351883,"threshold_uncertainty_score":0.2668867},"labels":[],"label_agreement":null},{"id":"W2772406204","doi":"10.1016/j.ejmech.2017.12.012","title":"Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Chemistry; Scissile bond; Peptidomimetic; Proteases; Cathepsin K; Pharmacology; Bradykinin; Protease; Cathepsin; Stereochemistry; In vitro; Biochemistry; Enzyme; Peptide; Receptor","score_opus":0.010986178639848786,"score_gpt":0.24088494367316182,"score_spread":0.22989876503331302,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2772406204","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9929049,0.0022475321,0.000056396893,0.0002131689,0.00010298752,0.00004030032,0.0000038211606,0.000002088388,0.0044288086],"genre_scores_gemma":[0.9979868,0.0007504525,0.0002800819,0.000056015248,0.00074308383,3.303636e-7,0.0000028529782,0.000017794131,0.00016261324],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99913174,0.00005970058,0.00035595702,0.00015413872,0.00017087041,0.00012759365],"domain_scores_gemma":[0.998866,0.000010283664,0.0005806766,0.0002451836,0.00011682114,0.000181039],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006990412,0.00013323911,0.00021295753,0.00001863843,0.00010797805,0.000029675535,0.00023336602,0.000055612105,0.000017020953],"category_scores_gemma":[0.0004252755,0.0001079575,0.00006687424,0.000012432518,0.0002907024,0.0000107762,0.00011432702,0.000172857,9.795156e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021826953,0.000025246249,0.00061892625,0.000056312438,0.000045429944,0.000118191565,0.00007931009,2.5920164e-7,0.99625385,0.000004857337,0.00033777344,0.0022415966],"study_design_scores_gemma":[0.001404964,0.00061886484,0.0021365436,0.00020206247,0.000047479338,0.0006432041,0.00025644753,0.0000013015417,0.9928637,0.00006584321,0.0016543558,0.00010521577],"about_ca_topic_score_codex":0.000004559983,"about_ca_topic_score_gemma":4.97165e-7,"teacher_disagreement_score":0.0050818794,"about_ca_system_score_codex":0.000004560164,"about_ca_system_score_gemma":0.000072283954,"threshold_uncertainty_score":0.44023794},"labels":[],"label_agreement":null},{"id":"W2772709000","doi":"10.1016/j.ejmech.2017.11.068","title":"2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Higher Education Commision, Pakistan; Higher Education Commission, Pakistan; Crohn's and Colitis Canada; Organisation for the Prohibition of Chemical Weapons; Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Docking (animal); Alkaline phosphatase; Pyrophosphate; Isozyme; Active site; Stereochemistry; Trifluoromethyl; Enzyme; Molecular model; Biochemistry; Organic chemistry","score_opus":0.02816607714901979,"score_gpt":0.32649853365607606,"score_spread":0.29833245650705625,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2772709000","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9851934,0.010626701,0.00005776733,0.0025842758,0.00017953284,0.00026697983,0.000037060025,0.000024586634,0.0010297108],"genre_scores_gemma":[0.99794364,0.0005212833,0.00041575253,0.00007616902,0.00093104946,0.0000025705092,0.000012126428,0.000050284583,0.000047134494],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99714035,0.00030690432,0.0006736227,0.0003707403,0.0011418108,0.00036656894],"domain_scores_gemma":[0.99680513,0.0003988559,0.000982923,0.0007399274,0.0004638715,0.0006092719],"candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0024791493,0.00034703553,0.0007357743,0.00012090544,0.00059378985,0.000112142305,0.0004507365,0.00007366411,0.00013991559],"category_scores_gemma":[0.012623139,0.0002696982,0.00014098013,0.00013774578,0.00056149217,0.00030758404,0.00031593366,0.0013066721,0.000008963415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0059134373,0.0016818295,0.1391592,0.0017097315,0.003014712,0.07432703,0.0021864693,0.0000372089,0.71835333,0.00006150912,0.004831937,0.04872362],"study_design_scores_gemma":[0.00922516,0.0011386604,0.29529938,0.0022327679,0.0018574096,0.005440146,0.0021493423,0.00005229146,0.67878675,0.00017030172,0.003069363,0.0005784337],"about_ca_topic_score_codex":0.00004193635,"about_ca_topic_score_gemma":0.0000017569413,"teacher_disagreement_score":0.15614018,"about_ca_system_score_codex":0.00010488893,"about_ca_system_score_gemma":0.00025956004,"threshold_uncertainty_score":0.9999755},"labels":[],"label_agreement":null},{"id":"W2775804057","doi":"10.1016/j.ejmech.2017.11.079","title":"Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile","year":2017,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Riboswitch; Guanine; Chemistry; Purine; Purine metabolism; Biochemistry; Stereochemistry; RNA; Enzyme; Nucleotide; Non-coding RNA; Gene","score_opus":0.017803521799018233,"score_gpt":0.2860927273228949,"score_spread":0.2682892055238767,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2775804057","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9584074,0.0022697065,0.000089773086,0.0076643294,0.00041474943,0.00015478545,0.0000147256815,0.000027017846,0.030957483],"genre_scores_gemma":[0.9901952,0.0016447727,0.00016830984,0.00028935823,0.0053107482,2.3302515e-7,0.000026074644,0.00007264805,0.0022926182],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9962842,0.00017231466,0.0010781644,0.00034066924,0.001505536,0.0006191544],"domain_scores_gemma":[0.9964985,0.00012212519,0.0010881312,0.0009541492,0.00074486656,0.0005921923],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0025091888,0.00036534105,0.00065509847,0.00008859363,0.0007539586,0.0001975066,0.0012122398,0.000091056805,0.00045308683],"category_scores_gemma":[0.0033386452,0.00023568184,0.0004192321,0.00014758958,0.00062837877,0.00012745798,0.0003871886,0.001709908,0.00008292816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008758389,0.00031626128,0.0017768042,0.00023747448,0.00030218673,0.011461345,0.00012475828,0.000042832482,0.955461,0.000005173611,0.015363918,0.014032388],"study_design_scores_gemma":[0.0052642706,0.0010388403,0.007140137,0.0009696448,0.00049764954,0.00536622,0.0014747315,0.00027691975,0.9550995,0.00001321233,0.022507692,0.00035115535],"about_ca_topic_score_codex":0.000018322544,"about_ca_topic_score_gemma":5.4374004e-7,"teacher_disagreement_score":0.03178781,"about_ca_system_score_codex":0.0001451852,"about_ca_system_score_gemma":0.0004226437,"threshold_uncertainty_score":0.9610827},"labels":[],"label_agreement":null},{"id":"W2783484894","doi":"10.1016/j.ejmech.2018.01.021","title":"Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Celgene","keywords":"Chemistry; Histone deacetylase; Tubulin; Carboxamide; Stereochemistry; Cytotoxicity; Docking (animal); Triazole; Histone; Microtubule; Biochemistry; In vitro; DNA; Cell biology; Biology","score_opus":0.034817907610423214,"score_gpt":0.3329971388446725,"score_spread":0.29817923123424933,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2783484894","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9915052,0.005609949,0.000696104,0.00021420133,0.00009107612,0.00012090901,0.00000461055,0.0000045997117,0.0017533716],"genre_scores_gemma":[0.99706894,0.00073006033,0.0010357583,0.000045592984,0.0010170434,0.0000023692253,0.0000062586705,0.000026584286,0.00006736323],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9977003,0.000637451,0.0006083717,0.0002923377,0.00053663645,0.00022490036],"domain_scores_gemma":[0.9984199,0.0001284019,0.00046783846,0.00021406013,0.00052093965,0.00024887954],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0033191754,0.00020229048,0.0003151314,0.00007761805,0.00009131678,0.000014223455,0.00022038123,0.000098108474,0.000073661955],"category_scores_gemma":[0.0035373238,0.0001637054,0.0000680517,0.00011579565,0.0010750748,0.000010605251,0.00013872713,0.00026005955,0.0000034023444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00052846817,0.000059184687,0.00030323776,0.000050839462,0.00007043271,0.000060524035,0.00019179609,0.0000031078664,0.9877824,0.0000013547418,0.0011670784,0.0097815655],"study_design_scores_gemma":[0.001216427,0.0012327346,0.0021753456,0.0002501238,0.00006816605,0.0007952697,0.00032969005,0.000033463566,0.99175686,0.000014875063,0.0019701049,0.00015697264],"about_ca_topic_score_codex":0.000004239709,"about_ca_topic_score_gemma":6.0715047e-7,"teacher_disagreement_score":0.009624593,"about_ca_system_score_codex":0.000046302466,"about_ca_system_score_gemma":0.00023054134,"threshold_uncertainty_score":0.6675712},"labels":[],"label_agreement":null},{"id":"W2788163753","doi":"10.1016/j.ejmech.2018.01.053","title":"Effects of rigidity on the selectivity of protein kinase inhibitors","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Division of Chemistry; National Institute of Dental and Craniofacial Research; National Center for Research Resources; National Institute of General Medical Sciences; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; TD Bank; National Institutes of Health; National Science Foundation","keywords":"Kinase; Chemistry; Selectivity; Isoquinoline; Biochemistry; Structure–activity relationship; Stereochemistry; Combinatorial chemistry; Catalysis; In vitro","score_opus":0.006772026038693152,"score_gpt":0.20595523823113157,"score_spread":0.19918321219243842,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2788163753","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99181867,0.00035549785,0.00022764102,0.00011078196,0.00013101769,0.00008438624,0.0000031428963,0.000002014503,0.0072668516],"genre_scores_gemma":[0.9983222,0.000018866223,0.00008798378,0.000055248707,0.0013412808,7.7346726e-7,0.0000016239167,0.000014355295,0.00015765792],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99888116,0.00023472823,0.00034957958,0.00012425006,0.0002818593,0.0001284236],"domain_scores_gemma":[0.99889565,0.000047189656,0.00050234585,0.00021742866,0.00024432907,0.00009304077],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010228276,0.00012120755,0.00019206326,0.000019013309,0.00004025121,0.0000033029041,0.00027971482,0.0000437904,0.000026948936],"category_scores_gemma":[0.00079300895,0.00007683706,0.00011646495,0.00007313012,0.00027514715,0.000002531231,0.000058601687,0.00021637378,0.0000026134965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002912142,0.000114609276,0.0001747735,0.00016029186,0.00004676967,0.000051355317,0.00006267047,6.095903e-7,0.9950499,0.000008731586,0.002318799,0.0017203004],"study_design_scores_gemma":[0.0006470582,0.001863781,0.0014737543,0.00031472516,0.000031079195,0.000071137234,0.000038587084,0.0000013298154,0.9906781,0.000017958713,0.0047938786,0.000068645255],"about_ca_topic_score_codex":0.0000017939523,"about_ca_topic_score_gemma":2.8313605e-7,"teacher_disagreement_score":0.0071091936,"about_ca_system_score_codex":0.000009294159,"about_ca_system_score_gemma":0.00009704843,"threshold_uncertainty_score":0.3133324},"labels":[],"label_agreement":null},{"id":"W2790686872","doi":"10.1016/j.ejmech.2018.01.094","title":"Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; PROTEO","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies; Université Laval; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Sulfamide; Chemistry; Quinazoline; Piperidine; Phosphodiesterase; In vitro; Chemical synthesis; Pharmacology; Biochemistry; Stereochemistry; Enzyme; Organic chemistry","score_opus":0.05229545989393195,"score_gpt":0.298357572865839,"score_spread":0.24606211297190708,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2790686872","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97266656,0.000632351,0.00017676104,0.00025387984,0.00003873378,0.00003457986,0.000015810236,0.0000081419075,0.026173169],"genre_scores_gemma":[0.99806243,0.00015030777,0.0007630755,0.00001658749,0.0009334151,0.0000023052203,0.0000028520183,0.000020619482,0.00004838299],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99802405,0.00008833038,0.0009086414,0.00019494878,0.0006282575,0.00015578438],"domain_scores_gemma":[0.9974185,0.00029748504,0.0010591927,0.0002478304,0.0008315929,0.00014538651],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021287724,0.00017783589,0.00040937017,0.00004738357,0.000059269492,0.00000779892,0.00030404137,0.00006531365,0.0007928504],"category_scores_gemma":[0.002741048,0.00013493348,0.00011835336,0.00013115504,0.0006822234,0.00005936325,0.00007538043,0.00021307962,0.0000030130032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012522134,0.00020188933,0.0008726363,0.0001279381,0.000067937406,0.000006287213,0.00029173272,0.0000044317203,0.9847239,0.000025838192,0.00015740347,0.0133947665],"study_design_scores_gemma":[0.00090014597,0.00012318471,0.0034159916,0.00066514604,0.00018538568,0.00023624592,0.0013680286,0.00012969,0.9917751,0.000052193434,0.0010255588,0.00012332096],"about_ca_topic_score_codex":0.000004206711,"about_ca_topic_score_gemma":1.6831862e-7,"teacher_disagreement_score":0.026124787,"about_ca_system_score_codex":0.000034479544,"about_ca_system_score_gemma":0.00013261224,"threshold_uncertainty_score":0.8681156},"labels":[],"label_agreement":null},{"id":"W2792644844","doi":"10.1016/j.ejmech.2018.03.043","title":"New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ministerstvo Školství, Mládeže a Tělovýchovy; University of Ottawa","keywords":"Chemistry; HaCaT; Juglone; Bioassay; Oxidative stress; Kinetin; Biological activity; Antioxidant; Singlet oxygen; Cytokinin; Reactive oxygen species; Stereochemistry; Photoprotection; Biochemistry; In vitro; Organic chemistry; Oxygen; Tissue culture","score_opus":0.0641232843174508,"score_gpt":0.396574707801742,"score_spread":0.3324514234842912,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2792644844","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99052495,0.00041612278,0.00024675918,0.0001967511,0.00027410086,0.00014290887,0.000019006804,0.000010548403,0.008168855],"genre_scores_gemma":[0.9977038,0.00009387238,0.00014408224,0.00026855062,0.0012751363,0.0000010390122,0.000002501121,0.00002298017,0.00048803462],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982886,0.0006774602,0.0003406497,0.0002472237,0.00021590144,0.00023016873],"domain_scores_gemma":[0.9987733,0.00022378768,0.0004159351,0.00009863225,0.00012802315,0.00036033956],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010137884,0.00024329433,0.00032563912,0.000049785056,0.00023043487,0.000028139852,0.00022340518,0.00007234587,0.00046193838],"category_scores_gemma":[0.00008813944,0.00018619822,0.0000624914,0.000078918856,0.0005168313,0.0000798768,0.00009960403,0.00087646896,0.000007384455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009119836,0.00017596156,0.0019828123,0.00012128039,0.00028134484,0.00049248885,0.0016283504,0.0000012893488,0.9750881,0.000009823415,0.0017958422,0.017510707],"study_design_scores_gemma":[0.0027223628,0.0027395105,0.013569563,0.00037275426,0.00013651531,0.0002569917,0.0004508325,0.00000897219,0.97533095,0.000052442523,0.0041825194,0.00017661123],"about_ca_topic_score_codex":0.0000042352435,"about_ca_topic_score_gemma":6.957732e-7,"teacher_disagreement_score":0.017334096,"about_ca_system_score_codex":0.000040909687,"about_ca_system_score_gemma":0.00004677642,"threshold_uncertainty_score":0.7592943},"labels":[],"label_agreement":null},{"id":"W2795332116","doi":"10.1016/j.ejmech.2018.03.078","title":"Syntheses and anti-pancreatic cancer activities of rakicidin A analogues","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Science Fund for Distinguished Young Scholars; Natural Science Foundation of Tianjin City; National Natural Science Foundation of China; Public Health Agency of Canada","keywords":"Pancreatic cancer; CD44; Chemistry; Cancer research; Cancer stem cell; IC50; Metastasis; Cancer; Internal medicine; Medicine; Cell; In vitro; Biochemistry","score_opus":0.017611566135226044,"score_gpt":0.26424063979936624,"score_spread":0.2466290736641402,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2795332116","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9904848,0.0052025225,0.00061025354,0.00012289328,0.00012905721,0.000024257808,0.0000111859945,0.0000021617564,0.0034129086],"genre_scores_gemma":[0.9960198,0.0022866672,0.00022943172,0.0001247389,0.0011152704,4.896921e-7,0.0000019526644,0.000018285522,0.00020339181],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9992692,0.000060380677,0.00026624516,0.00011753778,0.00016163575,0.00012500798],"domain_scores_gemma":[0.99932903,0.000020254252,0.000295352,0.00013058248,0.00013244442,0.00009236456],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197507,0.00011087544,0.00021677236,0.000025677116,0.000035875073,0.0000086762775,0.0001539155,0.00003109291,0.00006917567],"category_scores_gemma":[0.00008701212,0.00008862002,0.000063729545,0.000042179625,0.00025701727,0.000004064202,0.000049387618,0.00009765142,3.9874976e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001739478,0.000023900713,0.00044113598,0.00007042038,0.00013380997,0.000021322165,0.0001653967,0.0000012813842,0.9897374,0.000005071057,0.0003187822,0.008907521],"study_design_scores_gemma":[0.0004476201,0.0005111315,0.0007847024,0.00032968054,0.0001045736,0.00024352747,0.0005297669,0.0000055147925,0.98701936,0.000014179415,0.009916291,0.00009366875],"about_ca_topic_score_codex":0.000006461189,"about_ca_topic_score_gemma":0.000002122953,"teacher_disagreement_score":0.009597508,"about_ca_system_score_codex":0.00000929168,"about_ca_system_score_gemma":0.000082912724,"threshold_uncertainty_score":0.36138198},"labels":[],"label_agreement":null},{"id":"W2802472281","doi":"10.1016/j.ejmech.2018.04.038","title":"Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Arthritis Network; Ministerio de Economía y Competitividad; Federación Española de Enfermedades Raras; Universidad de Navarra; Generalitat de Catalunya","keywords":"Chemistry; In vivo; Plasmodium berghei; Pharmacology; Plasmodium falciparum; Parasitemia; Genotoxicity; Chloroquine; Cytotoxicity; In silico; Toxicity; In vitro; Stereochemistry; Malaria; Biochemistry; Biology; Immunology; Organic chemistry","score_opus":0.04425498713620051,"score_gpt":0.3039304598468057,"score_spread":0.2596754727106052,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2802472281","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99058515,0.0022801606,0.0040960647,0.002017051,0.00013264376,0.00036426363,0.000033863995,0.00002520869,0.0004655891],"genre_scores_gemma":[0.9940245,0.00021374959,0.0041014967,0.000080428224,0.0013347331,0.000002580708,0.00001420673,0.000034047644,0.00019423],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9974149,0.00035754382,0.00082536426,0.00029712982,0.00079034176,0.00031472207],"domain_scores_gemma":[0.99699026,0.00030834854,0.00084977003,0.00029396947,0.00096791144,0.0005897538],"candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0013680677,0.00026592796,0.0006915363,0.000114406444,0.00016606314,0.000023429626,0.00021935317,0.00008322679,0.0002511382],"category_scores_gemma":[0.00835532,0.00020550353,0.00010686593,0.00025218225,0.00053420465,0.00037234538,0.000098722565,0.00072689186,0.0000025890688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.015074026,0.00032975173,0.023514789,0.001313207,0.0009738324,0.000643312,0.0018514023,0.00005742801,0.95118636,0.000037645153,0.0020447664,0.0029734704],"study_design_scores_gemma":[0.006405095,0.003079443,0.1512984,0.0012713091,0.00046268973,0.00042244,0.0018620517,0.0009050526,0.83348304,0.00015469259,0.000357535,0.0002982568],"about_ca_topic_score_codex":0.000009328576,"about_ca_topic_score_gemma":8.36089e-7,"teacher_disagreement_score":0.12778361,"about_ca_system_score_codex":0.00007487139,"about_ca_system_score_gemma":0.00094649295,"threshold_uncertainty_score":0.99999774},"labels":[],"label_agreement":null},{"id":"W2804722210","doi":"10.1016/j.ejmech.2018.05.032","title":"Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Hacettepe Üniversitesi","keywords":"Pharmacophore; Chemistry; Calcium channel; Isradipine; Dihydropyridine; DHPS; Docking (animal); Nifedipine; Voltage-dependent calcium channel; Stereochemistry; L-type calcium channel; Cav1.2; Selectivity; Calcium; Biochemistry","score_opus":0.0868755735326616,"score_gpt":0.2992878548771291,"score_spread":0.2124122813444675,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2804722210","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9951256,0.00012708845,0.0021210127,0.0012893857,0.00012233136,0.00009180789,0.000009903238,0.0000141699,0.0010987225],"genre_scores_gemma":[0.99772334,0.00002805485,0.0005096765,0.00031864998,0.0012735295,0.0000010929843,0.0000030733875,0.00003890566,0.000103686165],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984903,0.00014303495,0.00046284831,0.0001875651,0.00051808427,0.000198178],"domain_scores_gemma":[0.99785876,0.00027523836,0.00065891,0.00024591762,0.0007150361,0.00024615607],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074129505,0.0002093315,0.0003973668,0.00008405792,0.00018544839,0.000017398612,0.00021114103,0.00002869873,0.00007098796],"category_scores_gemma":[0.0014988118,0.00012609665,0.0001062459,0.00031945796,0.00047237278,0.00009789932,0.000054208307,0.00028200532,0.000002006448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00057032175,0.00015198856,0.00041520532,0.000114446164,0.00019087436,0.00023080932,0.0006674242,0.000015626332,0.99722415,0.000006524196,0.00025342556,0.00015921965],"study_design_scores_gemma":[0.0014846048,0.00057105126,0.0016070463,0.0015936145,0.00043638097,0.0012691432,0.00079052034,0.00038993434,0.9916168,0.0000047897042,0.00011576249,0.00012038245],"about_ca_topic_score_codex":0.000002276092,"about_ca_topic_score_gemma":3.2493372e-7,"teacher_disagreement_score":0.0056073647,"about_ca_system_score_codex":0.000038926453,"about_ca_system_score_gemma":0.00023804035,"threshold_uncertainty_score":0.51420724},"labels":[],"label_agreement":null},{"id":"W2804870229","doi":"10.1016/j.ejmech.2018.05.029","title":"Structure-based design and profiling of novel 17β-HSD14 inhibitors","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Deutscher Akademischer Austauschdienst; Deutsche Forschungsgemeinschaft; Providence Health Care","keywords":"Chemistry; Enzyme; Stereochemistry; Cofactor; Cytotoxicity; Lead compound; Enzyme inhibitor; Active site; Steroid; Selectivity; Combinatorial chemistry; Biochemistry; In vitro","score_opus":0.009791958613943191,"score_gpt":0.23061616590725367,"score_spread":0.22082420729331048,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2804870229","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98418796,0.0015734476,0.013123059,0.000068042755,0.00014604909,0.000056742025,0.0000033895708,0.0000034443733,0.000837868],"genre_scores_gemma":[0.98913205,0.00004119833,0.009657552,0.000067554356,0.0010350136,1.6445924e-7,0.000006591524,0.000023807985,0.000036055917],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990308,0.00009836801,0.00036875802,0.00014653572,0.00020865127,0.00014683505],"domain_scores_gemma":[0.99912184,0.000023193184,0.0003570763,0.00014275631,0.00020254932,0.00015258367],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000691287,0.00013952197,0.00018030303,0.00003013357,0.00004382802,0.000007840568,0.00017113214,0.000076316646,0.000013590753],"category_scores_gemma":[0.00020256639,0.00010602338,0.00007013889,0.00006422428,0.00028700926,0.000003492965,0.00004260958,0.00024128913,5.9820115e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035790706,0.000040109873,0.0002964202,0.00006486569,0.00006304249,0.000044318713,0.00003713836,0.0000822503,0.99730617,0.0000010611557,0.00049920985,0.0012075293],"study_design_scores_gemma":[0.0017151048,0.0011102359,0.00018468768,0.00018960057,0.000060378738,0.00047350102,0.000057206795,0.0001601932,0.9954135,0.0000031960926,0.0005292337,0.00010318619],"about_ca_topic_score_codex":3.8223203e-7,"about_ca_topic_score_gemma":2.6204937e-8,"teacher_disagreement_score":0.0049441047,"about_ca_system_score_codex":0.000007968153,"about_ca_system_score_gemma":0.000118017466,"threshold_uncertainty_score":0.43235078},"labels":[],"label_agreement":null},{"id":"W2805407226","doi":"10.1016/j.ejmech.2018.05.047","title":"Design, synthesis and in vitro evaluation of heterobivalent peptidic radioligands targeting both GRP- and VPAC1-Receptors concomitantly overexpressed on various malignancies – Is the concept feasible?","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Dr. Hella Bühler Stiftung","keywords":"Chemistry; In vitro; Receptor; Pharmacology; Stereochemistry; Chemical synthesis; Cancer research; Biochemistry","score_opus":0.028687326559001972,"score_gpt":0.2686205419654352,"score_spread":0.23993321540643325,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2805407226","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99571013,0.0014920356,0.00035073774,0.0009933966,0.000039017763,0.00012100371,0.000008018453,0.000006361799,0.0012792973],"genre_scores_gemma":[0.99854803,0.00023430077,0.00029188822,0.0004390163,0.0004002893,0.0000015487268,0.0000032213336,0.000020112488,0.00006156874],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99774456,0.0004794654,0.0006477492,0.00019318429,0.00075247796,0.00018254276],"domain_scores_gemma":[0.9984412,0.0003162985,0.0005583038,0.00016182513,0.0003452602,0.00017708742],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00329051,0.00018392166,0.0004483751,0.000096445954,0.00008351179,0.000020019006,0.00011355832,0.000042837688,0.00027765578],"category_scores_gemma":[0.0009724873,0.000121100995,0.00009130979,0.0001587364,0.00046903596,0.00006117535,0.000029666218,0.00030999669,0.0000015108777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010901869,0.00008274246,0.0005085894,0.00009669933,0.00013076521,0.000099384706,0.001879963,0.000021098778,0.9912315,7.117824e-7,0.002604267,0.0022540698],"study_design_scores_gemma":[0.0035522014,0.00052347785,0.002700438,0.0032296358,0.00046677297,0.0005093202,0.0017874973,0.0007383771,0.9861131,0.00001101824,0.00023825387,0.0001299279],"about_ca_topic_score_codex":0.0000035888513,"about_ca_topic_score_gemma":1.4333143e-7,"teacher_disagreement_score":0.0051184422,"about_ca_system_score_codex":0.000084200015,"about_ca_system_score_gemma":0.00013441253,"threshold_uncertainty_score":0.49383554},"labels":[],"label_agreement":null},{"id":"W2805560189","doi":"10.1016/j.ejmech.2018.06.007","title":"Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Meropenem; Antimicrobial; Carbapenem; Microbiology; Chemistry; Enterobacteriaceae; Antibiotics; Imipenem; Beta-Lactamase Inhibitors; Escherichia coli; Antibiotic resistance; Biology; Biochemistry","score_opus":0.0077359152611196445,"score_gpt":0.20831055074365798,"score_spread":0.20057463548253834,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2805560189","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99871266,0.0002879489,0.00014898549,0.00016161197,0.00019655064,0.00011292616,0.000011268502,0.0000019255167,0.0003661075],"genre_scores_gemma":[0.9990347,0.000116704694,0.00041903523,0.000043544132,0.00027542133,2.9605334e-7,0.00000829869,0.000023054865,0.000078934914],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984301,0.0002799979,0.0006828586,0.0001982445,0.00027547538,0.00013335685],"domain_scores_gemma":[0.9979227,0.00006770493,0.001184028,0.0003269766,0.0004219675,0.00007657717],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00062833406,0.00016293219,0.00033256342,0.00003695262,0.00005915422,0.000008935524,0.00035497203,0.000041254993,0.0000084777075],"category_scores_gemma":[0.00076102995,0.000121145,0.00008626012,0.000110563735,0.00083766336,0.000009820481,0.000118690376,0.00014864707,2.7599236e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034836406,0.00009495471,0.005682268,0.00062511035,0.000115432595,0.000005096951,0.00040112858,0.0000027895474,0.9922918,0.000012266923,0.00029233217,0.00012842195],"study_design_scores_gemma":[0.0011366989,0.00049637223,0.12690069,0.0017682095,0.00009277016,0.00002110265,0.000106478365,0.0000013674302,0.8693236,0.000010717816,0.00005810699,0.00008390742],"about_ca_topic_score_codex":0.0000041620274,"about_ca_topic_score_gemma":0.0000016986014,"teacher_disagreement_score":0.12296825,"about_ca_system_score_codex":0.00001706617,"about_ca_system_score_gemma":0.00011370206,"threshold_uncertainty_score":0.49401498},"labels":[],"label_agreement":null},{"id":"W2807910699","doi":"10.1016/j.ejmech.2018.06.028","title":"Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":75,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Erasmus+; Cement Association of Canada","keywords":"Chemistry; Varicella zoster virus; Triazole; Click chemistry; Virus; Azide; Alkyne; EC50; 1,2,3-Triazole; Molecule; Microwave irradiation; Combinatorial chemistry; Stereochemistry; In vitro; Virology; Organic chemistry; Catalysis; Biochemistry","score_opus":0.022819930916014055,"score_gpt":0.26528183391567656,"score_spread":0.2424619029996625,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2807910699","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.90678316,0.00084114197,0.00039264484,0.0004492126,0.0000780068,0.00004249252,0.000023924855,0.00002958409,0.091359824],"genre_scores_gemma":[0.9964721,0.00023327883,0.00029510388,0.00015368921,0.002332816,0.000004089456,0.000015632373,0.00004909727,0.0004441533],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9977591,0.00008708254,0.0007873964,0.0003477451,0.00071773445,0.0003009463],"domain_scores_gemma":[0.997891,0.00019322436,0.00068415195,0.00044321953,0.00044557115,0.0003427992],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0014165054,0.00028452312,0.0003648032,0.000037543596,0.0001924601,0.00006386291,0.00048851897,0.000064871296,0.0036046708],"category_scores_gemma":[0.0005131119,0.000253535,0.0001366108,0.00010813148,0.0003815798,0.00010461168,0.00012139249,0.0005063393,0.00006680726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009633912,0.000114123024,0.00011188416,0.00017340817,0.000109921806,0.00015284245,0.00018296816,0.000008463742,0.98611146,0.0000019807726,0.0022753442,0.010661237],"study_design_scores_gemma":[0.0010686122,0.00003365836,0.00015394235,0.00040033887,0.00037456,0.0015351301,0.00038495753,0.0004753839,0.98200417,0.00004264502,0.01327276,0.00025385452],"about_ca_topic_score_codex":0.0000030671094,"about_ca_topic_score_gemma":1.5752677e-7,"teacher_disagreement_score":0.09091567,"about_ca_system_score_codex":0.00008929145,"about_ca_system_score_gemma":0.00011721303,"threshold_uncertainty_score":0.9999917},"labels":[],"label_agreement":null},{"id":"W2809639506","doi":"10.1016/j.ejmech.2018.06.030","title":"Preparation, characterisation and biological evaluation of new N-phenyl amidobenzenesulfonates and N-phenyl ureidobenzenesulfonates inducing DNA double-strand breaks. Part 3. Modulation of ring A","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; DNA; Stereochemistry; DNA damage; Cell cycle; Mechanism of action; Moiety; Amide; DNA synthesis; Biochemistry; Cell; In vitro","score_opus":0.041991220248350246,"score_gpt":0.29502762109277775,"score_spread":0.2530364008444275,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2809639506","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9969047,0.0014089638,0.0007339138,0.00006645877,0.000098581404,0.00011262405,0.000009955223,0.0000033171277,0.0006615108],"genre_scores_gemma":[0.997907,0.000337077,0.0005663681,0.000022259603,0.00107382,9.76066e-7,0.00005474815,0.000015462289,0.000022279612],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984824,0.0001351932,0.00068326056,0.00025336564,0.0003113171,0.00013445104],"domain_scores_gemma":[0.99821794,0.000026349993,0.0008098033,0.00016086525,0.00065797474,0.00012706562],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014425418,0.00016895536,0.00027927957,0.00004083777,0.00005183492,0.000015342674,0.00013475076,0.00008792016,0.000030540432],"category_scores_gemma":[0.00032554872,0.00014530194,0.00005702129,0.00006370027,0.00022720754,0.000022615062,0.00006629964,0.00011943629,3.0453828e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00066809275,0.00003626794,0.0040526963,0.000069222326,0.0000736981,0.0000012653043,0.0005157771,0.00004139598,0.987499,0.0000042884008,0.00007486509,0.0069634076],"study_design_scores_gemma":[0.0026885471,0.000482509,0.06709157,0.00021456288,0.00010112211,0.00009128467,0.0002628674,0.0002379496,0.92822737,0.0001573964,0.00030949287,0.0001353138],"about_ca_topic_score_codex":0.0000059907775,"about_ca_topic_score_gemma":0.0000016062603,"teacher_disagreement_score":0.06303887,"about_ca_system_score_codex":0.000016428996,"about_ca_system_score_gemma":0.000110704845,"threshold_uncertainty_score":0.5925241},"labels":[],"label_agreement":null},{"id":"W2868155400","doi":"10.1016/j.ejmech.2018.07.002","title":"Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Higher Education Commision, Pakistan; Crohn's and Colitis Canada; Organisation for the Prohibition of Chemical Weapons","keywords":"Chemistry; Pyrazole; Alkaline phosphatase; Nucleotide; Nucleoside; Phosphodiesterase; Nucleoside triphosphate; Stereochemistry; Enzyme; Biochemistry; Alkaline hydrolysis; Enzyme inhibitor; Hydrolysis","score_opus":0.01690296047316101,"score_gpt":0.27058040884004086,"score_spread":0.25367744836687983,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2868155400","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98632294,0.010393236,0.0023108458,0.00036770036,0.000093050476,0.00016512403,0.00008037239,0.000008959821,0.00025778206],"genre_scores_gemma":[0.99495333,0.0027749678,0.0013133212,0.00020553534,0.0005245513,0.0000070519295,0.00007741742,0.000052780368,0.00009102334],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9979445,0.00013632161,0.00067838444,0.0003833574,0.0005382535,0.00031918043],"domain_scores_gemma":[0.99803734,0.000038982012,0.0005903175,0.00031114204,0.00074072514,0.00028150697],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008189181,0.00029857585,0.00043193853,0.000047411355,0.000118760545,0.000028334784,0.00023460091,0.000071600676,0.000074618074],"category_scores_gemma":[0.0005596197,0.00022708758,0.00010294137,0.00018522523,0.0010949342,0.00004501012,0.00018992944,0.00026407742,0.000004411269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002752035,0.00015622834,0.00013203689,0.0002637632,0.00030418436,0.00041366954,0.00021287228,0.000012424758,0.98923457,0.0000071053096,0.0024589866,0.0040521263],"study_design_scores_gemma":[0.0021034584,0.0013134212,0.00020409032,0.00067259715,0.00016623967,0.00016663429,0.00080254633,0.00003351781,0.99149704,0.000024959425,0.002773002,0.00024247958],"about_ca_topic_score_codex":0.0000109763105,"about_ca_topic_score_gemma":0.0000017772761,"teacher_disagreement_score":0.008630422,"about_ca_system_score_codex":0.000029191018,"about_ca_system_score_gemma":0.00013386489,"threshold_uncertainty_score":0.9260363},"labels":[],"label_agreement":null},{"id":"W2886716663","doi":"10.1016/j.ejmech.2018.08.014","title":"99mTc(CO)3+ labeled domain I/II-specific anti-EGFR (scFv)2 antibody fragment for imaging EGFR expression","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Royal University Hospital; Saskatoon Medical Imaging; University of Saskatchewan","funders":"","keywords":"Chemistry; Biodistribution; In vivo; In vitro; Histidine; Antibody; Immunoconjugate; Bifunctional; Biochemistry; Stereochemistry; Amino acid; Monoclonal antibody","score_opus":0.024401273348803366,"score_gpt":0.3443381562310689,"score_spread":0.3199368828822655,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2886716663","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95083135,0.0018978188,0.006699115,0.0054695597,0.00023531428,0.00023735878,0.000018170396,0.000050012848,0.034561295],"genre_scores_gemma":[0.9858607,0.00041121055,0.005951457,0.00064468256,0.0060799643,0.0000044131552,0.000049731556,0.00006367264,0.00093417667],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99763715,0.00007247124,0.00088573823,0.00035280336,0.00062095356,0.0004308531],"domain_scores_gemma":[0.997916,0.00011203388,0.00049953803,0.0004105409,0.00042908007,0.000632845],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013260362,0.00029016723,0.0004993952,0.000097647666,0.00032185554,0.000030686435,0.00039995706,0.00005941335,0.0007846891],"category_scores_gemma":[0.00017346656,0.00022848364,0.00023882218,0.0002961899,0.0004175455,0.000095263546,0.000071491486,0.00067083293,0.00003337947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005124634,0.00029281684,0.00042262784,0.00024077395,0.0000618043,0.00043776212,0.00025335985,0.0000011970317,0.96046144,0.000012471407,0.03495861,0.0023446793],"study_design_scores_gemma":[0.0039164107,0.00023845232,0.000563757,0.0007519259,0.00010913409,0.0014953413,0.0003907802,0.000030822084,0.6854584,0.00003374685,0.30684724,0.00016398457],"about_ca_topic_score_codex":2.8686225e-7,"about_ca_topic_score_gemma":7.515971e-9,"teacher_disagreement_score":0.27500302,"about_ca_system_score_codex":0.00011059367,"about_ca_system_score_gemma":0.00010600934,"threshold_uncertainty_score":0.9317292},"labels":[],"label_agreement":null},{"id":"W2888113308","doi":"10.1016/j.ejmech.2018.08.059","title":"Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Enzalutamide; Androgen receptor; Chemistry; Prostate cancer; Small molecule; Cancer research; Transcription factor; Androgen; Cell biology; Cancer; Hormone; Biochemistry; Biology; Genetics; Gene","score_opus":0.04066528702268219,"score_gpt":0.2871065211325999,"score_spread":0.2464412341099177,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2888113308","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9924338,0.0005379766,0.00003102835,0.0006149601,0.00006155325,0.00010139103,0.0000047714216,0.0000039286333,0.006210605],"genre_scores_gemma":[0.99891835,0.00013148558,0.000120629404,0.000030957282,0.00029340523,3.9675558e-7,0.000008612556,0.00001726342,0.00047892085],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988019,0.00008678202,0.00046866722,0.00010849797,0.00039120347,0.00014295343],"domain_scores_gemma":[0.9987882,0.000027212294,0.00044674243,0.00018488771,0.00039933683,0.00015362764],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00078417413,0.00011029321,0.0002702645,0.00004402493,0.000059741426,0.0000051557054,0.00016987226,0.0000337834,0.00010973018],"category_scores_gemma":[0.00016791155,0.00006000557,0.00008293119,0.00014065865,0.00026442157,0.000034330904,0.00005070154,0.0002718391,0.0000011908985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00075149693,0.000097261116,0.0013455284,0.00019805202,0.00015433827,0.00010039027,0.00042373486,6.320768e-8,0.9931666,0.000005503271,0.00028237925,0.0034746497],"study_design_scores_gemma":[0.0038378302,0.00198825,0.00494629,0.00077735586,0.0001801493,0.0006409179,0.0004474178,0.000010289012,0.9868089,0.000013580225,0.0002906767,0.000058353267],"about_ca_topic_score_codex":0.0000046226683,"about_ca_topic_score_gemma":7.7445094e-7,"teacher_disagreement_score":0.0064845434,"about_ca_system_score_codex":0.00004794035,"about_ca_system_score_gemma":0.0001681554,"threshold_uncertainty_score":0.2446956},"labels":[],"label_agreement":null},{"id":"W2888311017","doi":"10.1016/j.ejmech.2018.08.062","title":"Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; Lawson Health Research Institute","keywords":"Chemistry; Ghrelin; Receptor; Peptidomimetic; Secretagogue; Positron emission tomography; Growth hormone secretagogue receptor; Ligand (biochemistry); Endocrinology; Internal medicine; Stereochemistry; Peptide; Biochemistry; Nuclear medicine; Medicine","score_opus":0.013158647257084002,"score_gpt":0.2406492513832961,"score_spread":0.22749060412621208,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2888311017","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99188834,0.00031637578,0.0020569088,0.0018162177,0.00020731795,0.000085860855,0.0000058843525,0.000009811134,0.0036132648],"genre_scores_gemma":[0.99771184,0.000063770036,0.0008177681,0.00023789435,0.00089306454,3.541573e-7,0.0000010354902,0.00002021224,0.0002540351],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99849886,0.00019991702,0.0005028449,0.0001724902,0.0004534223,0.00017245917],"domain_scores_gemma":[0.9985115,0.00017620026,0.000687627,0.00019050148,0.00030138556,0.0001328152],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009046824,0.00013498688,0.00020612359,0.000050721566,0.00016481799,0.000018525747,0.0005214142,0.000021254404,0.00007101194],"category_scores_gemma":[0.0010710377,0.00008686049,0.0002004658,0.00022650321,0.00046802094,0.000111487825,0.00007447768,0.00023297632,0.000003159029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003017252,0.00004077607,0.0014694025,0.00004917723,0.000008700234,0.000007406554,0.0003370177,0.0000011764306,0.9935095,0.000010689958,0.0034152395,0.0008491984],"study_design_scores_gemma":[0.0010387321,0.000253989,0.011418376,0.0003375596,0.000036197267,0.00012003623,0.00016830685,0.000057677335,0.9831254,0.00010730132,0.0032475276,0.00008890307],"about_ca_topic_score_codex":7.090454e-7,"about_ca_topic_score_gemma":2.715642e-8,"teacher_disagreement_score":0.010384097,"about_ca_system_score_codex":0.000020544054,"about_ca_system_score_gemma":0.000056588022,"threshold_uncertainty_score":0.3542068},"labels":[],"label_agreement":null},{"id":"W2888966250","doi":"10.1016/j.ejmech.2018.08.095","title":"Recent developments of quinolone-based derivatives and their activities against Escherichia coli","year":2018,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TRIUMF","funders":"Natural Science Foundation of Jiangsu Province; China Postdoctoral Science Foundation","keywords":"Quinolone; Escherichia coli; Chemistry; Antibiotics; Drug; Potency; Microbiology; Pharmacology; Medicine; Biology; In vitro; Biochemistry","score_opus":0.05377441941992655,"score_gpt":0.31833422298963737,"score_spread":0.2645598035697108,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2888966250","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.034115005,0.9609146,0.000107237356,0.00011187488,0.00020034578,0.00015444329,0.0000142676945,0.0000091735565,0.004373015],"genre_scores_gemma":[0.012964717,0.98496395,0.00093853247,0.00013815808,0.000758453,3.845814e-7,0.00002867464,0.00007194617,0.00013520697],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9978644,0.00019953176,0.0011035794,0.00022002774,0.00038028628,0.00023215867],"domain_scores_gemma":[0.9974964,0.00015632989,0.0015264656,0.00021249132,0.00030299686,0.00030527814],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008973134,0.0004063046,0.001573323,0.00011055906,0.000048930713,0.0000139897475,0.000275676,0.00009561044,0.00007925615],"category_scores_gemma":[0.00031755824,0.00026642688,0.0002539203,0.00018471498,0.00046429707,0.000027882994,0.00009451368,0.00077841786,0.0000030101771],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026162347,0.00026977656,0.000035043147,0.023010649,0.0009791746,0.00048924563,0.0003778395,4.268956e-7,0.009664104,4.807918e-7,0.0022726888,0.962639],"study_design_scores_gemma":[0.001601098,0.00042836537,0.00014510055,0.0426315,0.0007937721,0.00036083176,0.00022132306,0.000004816686,0.013719693,5.625994e-7,0.93985224,0.00024072899],"about_ca_topic_score_codex":1.3210446e-7,"about_ca_topic_score_gemma":1.6372368e-8,"teacher_disagreement_score":0.96239823,"about_ca_system_score_codex":0.00007691599,"about_ca_system_score_gemma":0.00079131016,"threshold_uncertainty_score":0.9999788},"labels":[],"label_agreement":null},{"id":"W2889257132","doi":"10.1016/j.ejmech.2018.08.061","title":"Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA)","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TRIUMF","funders":"","keywords":"Quinolone; Staphylococcus aureus; Antibiotics; Methicillin-resistant Staphylococcus aureus; Microbiology; Pathogen; Chemistry; Antibacterial agent; Bacteria; Biology","score_opus":0.02171125008498774,"score_gpt":0.26707292892880774,"score_spread":0.24536167884381999,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2889257132","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97624606,0.0033558565,0.0016303647,0.0015139447,0.00020690593,0.00012628446,0.000019792704,0.00003854616,0.016862266],"genre_scores_gemma":[0.9942007,0.0006304212,0.0015812471,0.0008946743,0.0021334202,8.46174e-7,0.0000045187503,0.00006638093,0.00048776387],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99764353,0.00023208001,0.0008278634,0.00031704523,0.00054748444,0.0004319691],"domain_scores_gemma":[0.9976214,0.00026075542,0.0007433049,0.0003753637,0.0005501368,0.00044903098],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0014200052,0.00037708913,0.00073924824,0.00012651982,0.00018455228,0.0000421621,0.0003275413,0.00009231651,0.0001368421],"category_scores_gemma":[0.00088919385,0.0002684882,0.00019665011,0.00022975248,0.0015524534,0.00013440124,0.000116482646,0.00095444306,0.000008681452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015037506,0.000100884776,0.00052855397,0.00028002786,0.00027664014,0.00092083396,0.0018840962,9.263059e-7,0.9830367,0.000008009419,0.0029727914,0.008486794],"study_design_scores_gemma":[0.002962353,0.0014036468,0.009095958,0.001962037,0.0001825542,0.00015412254,0.0060666148,0.000014144604,0.9398418,0.00005224561,0.037915062,0.00034943467],"about_ca_topic_score_codex":0.000002228777,"about_ca_topic_score_gemma":0.000001421193,"teacher_disagreement_score":0.043194864,"about_ca_system_score_codex":0.00011523229,"about_ca_system_score_gemma":0.00029094116,"threshold_uncertainty_score":0.99997675},"labels":[],"label_agreement":null},{"id":"W2890423835","doi":"10.1016/j.ejmech.2018.09.043","title":"In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"UCI Beall Applied Innovation; National Institutes of Health; Cancer Research Coordinating Committee; National Institute of General Medical Sciences; Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Chemistry; Pyrrolidine; Pyrrolizidine; Epigenetics; Downregulation and upregulation; Stereochemistry; Biochemistry","score_opus":0.015742025997292002,"score_gpt":0.2672198775750419,"score_spread":0.2514778515777499,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2890423835","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99179804,0.006338603,0.00020620298,0.00012452445,0.00012230873,0.000043279153,0.0000047775998,0.0000022978222,0.0013599768],"genre_scores_gemma":[0.9960169,0.0012777161,0.00090016454,0.00016762891,0.0015773822,2.8258881e-7,0.000004437707,0.000023817225,0.000031653235],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985272,0.00014891145,0.000567357,0.00022934748,0.0002742788,0.00025290094],"domain_scores_gemma":[0.9991195,0.00003612479,0.0003289799,0.00012567414,0.00020001002,0.00018970783],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00171574,0.00016515194,0.0003413592,0.000058662587,0.00006173686,0.000017223038,0.00015190305,0.000051276027,0.000058414276],"category_scores_gemma":[0.000582341,0.00014437796,0.000056310764,0.000117972064,0.00039974076,0.000012267756,0.00011621891,0.00025787146,7.054685e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00016912333,0.000029676561,0.0030748749,0.000082875966,0.00006065636,0.00012016547,0.0006754111,0.000008993849,0.9925015,0.000005981468,0.00013843716,0.0031323272],"study_design_scores_gemma":[0.002165047,0.0003162381,0.008117596,0.00022873118,0.00006940745,0.00051514775,0.001100082,0.00007481955,0.98384446,0.000014161333,0.003395191,0.00015909532],"about_ca_topic_score_codex":0.000010771581,"about_ca_topic_score_gemma":6.751294e-7,"teacher_disagreement_score":0.008656993,"about_ca_system_score_codex":0.000005623627,"about_ca_system_score_gemma":0.00010671241,"threshold_uncertainty_score":0.5887562},"labels":[],"label_agreement":null},{"id":"W2890480825","doi":"10.1016/j.ejmech.2018.09.049","title":"Design, synthesis and anti-mycobacterial activity evaluation of benzofuran-isatin hybrids","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"TRIUMF","funders":"Natural Science Foundation of Jiangsu Province; China Postdoctoral Science Foundation","keywords":"Benzofuran; Cytotoxicity; Vero cell; Chemistry; Mycobacterium tuberculosis; Ethambutol; Rifampicin; Isatin; Isoniazid; In vivo; In vitro; Microbiology; Tuberculosis; Pharmacology; Stereochemistry; Antibiotics; Biochemistry; Biology; Medicine; Organic chemistry; Biotechnology","score_opus":0.0345980448756822,"score_gpt":0.2791004757944998,"score_spread":0.24450243091881763,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2890480825","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99231195,0.000497811,0.005796198,0.00009582088,0.00022769584,0.00005476989,0.0000057295033,0.0000018560067,0.0010081744],"genre_scores_gemma":[0.99772996,0.00018814279,0.00061680283,0.000041941214,0.0013777413,7.5570426e-7,0.0000021865987,0.000018113009,0.000024384984],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99884796,0.00025893436,0.00027848865,0.00014244733,0.00035467872,0.00011748897],"domain_scores_gemma":[0.9989555,0.000021414839,0.00036751002,0.00016181111,0.00039841715,0.000095379844],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0024043622,0.00011391436,0.00018688918,0.000021599499,0.000040293144,0.000010795032,0.00015342777,0.00003853154,0.00009178013],"category_scores_gemma":[0.00024471767,0.00009762381,0.000058499536,0.000037881546,0.00012811909,0.0000050574818,0.000044729884,0.00009727979,9.0569375e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038680903,0.000033220473,0.000042977223,0.00002557073,0.000080020865,0.0000070580027,0.00006528374,0.000005684534,0.9569303,5.004605e-7,0.00018087866,0.04224173],"study_design_scores_gemma":[0.0010771888,0.0005089229,0.0014009879,0.00010032523,0.0001945735,0.00021300177,0.00007523039,0.0000771956,0.9949121,0.000017281725,0.0013299636,0.0000932421],"about_ca_topic_score_codex":0.0000015140897,"about_ca_topic_score_gemma":2.6206845e-7,"teacher_disagreement_score":0.04214849,"about_ca_system_score_codex":0.00001756306,"about_ca_system_score_gemma":0.00015118309,"threshold_uncertainty_score":0.39809832},"labels":[],"label_agreement":null},{"id":"W2891421253","doi":"10.1016/j.ejmech.2018.09.023","title":"Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Prostate Cancer Canada; Government of Canada","keywords":"In silico; Prostate cancer; Virtual screening; Cancer research; Drug discovery; Transcription factor; Chemistry; Cell growth; Mechanism of action; Proto-Oncogene Proteins c-myc; Computational biology; Gene; Cancer; Biology; In vitro; Biochemistry; Genetics","score_opus":0.011032803513247466,"score_gpt":0.2569799886497775,"score_spread":0.24594718513653002,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2891421253","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9925442,0.0020321126,0.0030629826,0.00039233683,0.0005407589,0.000120575176,0.000040434785,0.0000045053,0.0012621038],"genre_scores_gemma":[0.9923447,0.00035874054,0.0008845215,0.00034433216,0.0051476844,0.0000020038417,0.000020532818,0.000036518202,0.00086100225],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99873364,0.00009500493,0.0005073511,0.00018758251,0.00026449552,0.00021194668],"domain_scores_gemma":[0.9987521,0.000016307491,0.00053931965,0.00018707459,0.00038915858,0.00011603017],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00070817786,0.00016907134,0.00023111787,0.000024363984,0.000062975676,0.000021964443,0.00031034066,0.0000469493,0.000032474247],"category_scores_gemma":[0.00005586132,0.0001353406,0.00017765313,0.000052938874,0.000255307,0.000009495193,0.00008560024,0.00017686469,0.0000022521772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00077600067,0.00006374894,0.00020442223,0.0001384669,0.0001419509,0.000036074933,0.00030506923,0.000015173807,0.9836766,0.0000019915524,0.0035285733,0.0111119095],"study_design_scores_gemma":[0.0016013328,0.001121541,0.00019223758,0.0002736376,0.00008633678,0.00020381575,0.00021354009,0.00003133105,0.96969795,0.00003209939,0.026399424,0.000146752],"about_ca_topic_score_codex":0.0000037266016,"about_ca_topic_score_gemma":6.1714934e-7,"teacher_disagreement_score":0.022870852,"about_ca_system_score_codex":0.000015281226,"about_ca_system_score_gemma":0.00020110422,"threshold_uncertainty_score":0.5519029},"labels":[],"label_agreement":null},{"id":"W2894471886","doi":"10.1016/j.ejmech.2018.09.063","title":"Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Higher Education Commision, Pakistan; Crohn's and Colitis Canada; Organisation for the Prohibition of Chemical Weapons; Canadian Institutes of Health Research; Higher Education Commission, Pakistan","keywords":"Chemistry; Benzothiazine; Chalcone; Alkaline phosphatase; Aldol condensation; Isozyme; Stereochemistry; Pharmacophore; Enzyme; Organic chemistry","score_opus":0.015433711040460797,"score_gpt":0.30050212075732813,"score_spread":0.2850684097168673,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2894471886","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9458192,0.046754207,0.000057915997,0.0017422616,0.00022553392,0.00014322667,0.00016475719,0.000021666265,0.0050712535],"genre_scores_gemma":[0.99151784,0.0035875682,0.0006135685,0.0003940359,0.0035503882,9.98046e-7,0.00007154514,0.000049236805,0.00021483953],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9972879,0.00015353279,0.00093991775,0.00029882631,0.0009739188,0.00034584757],"domain_scores_gemma":[0.9971696,0.0002644698,0.000705857,0.00025706374,0.0010338051,0.0005692191],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013209961,0.00030660324,0.00079193676,0.00011017329,0.00010967053,0.00001529236,0.00024904677,0.000033741835,0.0005776094],"category_scores_gemma":[0.0011730694,0.0002353909,0.00014287845,0.00021537588,0.0011217573,0.00011870159,0.0001991568,0.00070724956,0.000030197683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0049659866,0.00049225334,0.00207993,0.00047309423,0.0015006803,0.0052336734,0.0012180711,7.30456e-7,0.84231806,0.000011363354,0.1330766,0.008629584],"study_design_scores_gemma":[0.0067170123,0.0019885201,0.0022809135,0.0012491029,0.00048811355,0.0022450185,0.00078558066,0.000050276238,0.96396685,0.00011320702,0.01991759,0.00019780065],"about_ca_topic_score_codex":0.00006124049,"about_ca_topic_score_gemma":6.366777e-7,"teacher_disagreement_score":0.121648826,"about_ca_system_score_codex":0.000078324454,"about_ca_system_score_gemma":0.00026106264,"threshold_uncertainty_score":0.9598962},"labels":[],"label_agreement":null},{"id":"W2898075338","doi":"10.1016/j.ejmech.2018.10.039","title":"Design, synthesis and antibacterial evaluation of 2,4-disubstituted-6-thiophenyl-pyrimidines","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":57,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Hong Kong Polytechnic University; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"FtsZ; Antibacterial activity; Chemistry; GTPase; In vivo; Bacterial cell structure; Cell division; Antibacterial agent; Microbiology; Bacteria; Biochemistry; Antibiotics; Cell; Biology; Biotechnology","score_opus":0.0657648677361435,"score_gpt":0.2743983765745354,"score_spread":0.20863350883839193,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2898075338","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98602504,0.00044362238,0.00038092793,0.00013722114,0.00013108227,0.000025887712,0.0000052931396,0.000010903272,0.012840011],"genre_scores_gemma":[0.9971711,0.000099983044,0.00070709025,0.000017742024,0.0019629446,6.429857e-7,0.0000013763588,0.000014283457,0.00002482652],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982279,0.00025817,0.0005645886,0.00018006071,0.0005930947,0.00017617586],"domain_scores_gemma":[0.9981252,0.0003334601,0.00066791516,0.00017295011,0.00054533134,0.00015512387],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0037368294,0.00016782101,0.00036289316,0.000026387024,0.00006657299,0.000017332755,0.00026814715,0.000090154805,0.0022639178],"category_scores_gemma":[0.0022349863,0.000114183815,0.00008730607,0.000069034715,0.00040432691,0.000084919026,0.00005741746,0.00026790862,0.0000042732754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00038289296,0.00009095887,0.00061175425,0.00009508642,0.00007092337,0.000032962056,0.00007456991,0.0000014181983,0.9484075,6.4725265e-7,0.00017649047,0.050054837],"study_design_scores_gemma":[0.0006959209,0.000120651275,0.003608954,0.00045848233,0.0002835653,0.00031126218,0.00013765805,0.00012539934,0.99348396,0.000038443366,0.0006107719,0.00012495357],"about_ca_topic_score_codex":0.000001749222,"about_ca_topic_score_gemma":1.1008362e-7,"teacher_disagreement_score":0.049929883,"about_ca_system_score_codex":0.000038713104,"about_ca_system_score_gemma":0.0000956978,"threshold_uncertainty_score":0.99864817},"labels":[],"label_agreement":null},{"id":"W2900963324","doi":"10.1016/j.ejmech.2018.11.047","title":"In vitro and in vivo anti-tumor activity of two gold(III) complexes with isoquinoline derivatives as ligands","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Postdoctoral Science Foundation of Guangxi Province of China; Natural Science Foundation of Guangxi Province; National Natural Science Foundation of China","keywords":"Chemistry; Isoquinoline; In vivo; Apoptosis; Downregulation and upregulation; Cisplatin; In vitro; Mitochondrion; Cytotoxicity; Cell cycle; Cyclin A; Cell biology; Cyclin; Stereochemistry; Biochemistry; Biology; Chemotherapy","score_opus":0.02545607701563933,"score_gpt":0.27519095943711014,"score_spread":0.2497348824214708,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2900963324","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900726,0.00081717334,0.000053665946,0.0005693627,0.000037843678,0.000068368194,0.0000028725394,0.000004597383,0.008373495],"genre_scores_gemma":[0.9983238,0.00008682282,0.0006136436,0.00022206706,0.00046153498,4.414612e-7,5.686975e-7,0.000023255112,0.0002678804],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99855644,0.00012209092,0.00057131227,0.00017108521,0.00037916627,0.00019993498],"domain_scores_gemma":[0.9989638,0.00009603962,0.0004324209,0.00016813185,0.00018101001,0.00015860068],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010116508,0.00018460634,0.0006858277,0.00011447782,0.000024511752,0.000010230852,0.00015402773,0.000019446406,0.00020104655],"category_scores_gemma":[0.00024849066,0.00012030746,0.00004817185,0.00018536871,0.00053131167,0.00011651523,0.000057500343,0.00037982222,0.0000016502138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0041700527,0.0001562429,0.0031411392,0.00024070793,0.00005062061,0.0006618776,0.00064001716,9.840434e-7,0.98991287,0.0000020579507,0.00013809244,0.0008853118],"study_design_scores_gemma":[0.0038382665,0.0011345939,0.018832663,0.0014235231,0.00005747966,0.002108288,0.00044724386,0.000039254563,0.9713484,0.000014963081,0.00063981616,0.000115509516],"about_ca_topic_score_codex":0.00002973203,"about_ca_topic_score_gemma":0.000003708441,"teacher_disagreement_score":0.018564496,"about_ca_system_score_codex":0.000028102975,"about_ca_system_score_gemma":0.00010207564,"threshold_uncertainty_score":0.49059957},"labels":[],"label_agreement":null},{"id":"W2901500238","doi":"10.1016/j.ejmech.2018.11.052","title":"Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Hong Kong Polytechnic University; Innovation and Technology Commission","keywords":"FtsZ; Chemistry; Cytotoxicity; Antibiotics; Staphylococcus aureus; Microbiology; Pharmacology; In vitro; Bacteria; Biochemistry; Cell division; Cell; Biology","score_opus":0.01206723399212599,"score_gpt":0.2591370531365739,"score_spread":0.24706981914444792,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2901500238","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9952585,0.0006180135,0.00093499135,0.00013248342,0.0002668232,0.00008605344,0.0000064671735,0.000006220936,0.0026904258],"genre_scores_gemma":[0.99521005,0.00024252778,0.0015832192,0.00014323623,0.002515511,4.4307672e-8,0.000010693793,0.00004786409,0.00024682964],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99809986,0.00016934596,0.0007650019,0.00030008398,0.00036168148,0.00030401174],"domain_scores_gemma":[0.9979645,0.000049121107,0.00087516435,0.00046678964,0.00041685152,0.00022759382],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013462965,0.00025113838,0.00035253703,0.000039391365,0.00014537974,0.00005540274,0.00066825195,0.00009555094,0.000049125894],"category_scores_gemma":[0.0005000387,0.00017557031,0.000099406105,0.00014994304,0.000828559,0.000024431098,0.00019310247,0.0003164476,0.000005242806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00032860562,0.00009872011,0.018001985,0.000114703646,0.000074841184,0.00008197248,0.00010363536,0.0000026199657,0.9781818,4.7919974e-7,0.0014906296,0.0015200389],"study_design_scores_gemma":[0.0013807339,0.0009932532,0.072464176,0.00046487097,0.00009209211,0.00042537763,0.0002703725,0.00003876708,0.92149246,0.0000031850147,0.0021716808,0.00020306537],"about_ca_topic_score_codex":0.0000030619447,"about_ca_topic_score_gemma":8.7110755e-7,"teacher_disagreement_score":0.05668934,"about_ca_system_score_codex":0.000015269077,"about_ca_system_score_gemma":0.00016247419,"threshold_uncertainty_score":0.71595496},"labels":[],"label_agreement":null},{"id":"W2905360468","doi":"10.1016/j.ejmech.2018.12.016","title":"The therapeutic potential of curcumin: A review of clinical trials","year":2018,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":496,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Winnipeg","funders":"Fundação para a Ciência e a Tecnologia","keywords":"Curcumin; Curcuma; Clinical trial; Pharmacology; In vivo; Ex vivo; Medicine; Traditional medicine; Internal medicine; Biology; Biotechnology","score_opus":0.15007998175408785,"score_gpt":0.4736414979642771,"score_spread":0.32356151621018925,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2905360468","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000034678662,0.99671066,0.00074029027,0.0002934565,0.0004263058,0.00029767345,0.000050065533,0.000002347516,0.0014445259],"genre_scores_gemma":[0.00022276225,0.994377,0.00013618649,0.00013901226,0.0046870285,0.000004915032,0.000075032265,0.000051590294,0.0003064309],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9905657,0.0025237338,0.005634096,0.000320667,0.00072773726,0.00022801975],"domain_scores_gemma":[0.9900517,0.00059995096,0.0075676073,0.000840258,0.000669093,0.00027142902],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.022274688,0.00034197926,0.0026659828,0.00003342551,0.00005458199,0.0000089095765,0.0014836413,0.00022583746,0.00013384703],"category_scores_gemma":[0.0069818096,0.00018769721,0.0020730398,0.00020993664,0.0010939194,0.0000024232932,0.00021989686,0.0007287135,0.000010014162],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009203288,0.00013891597,0.0000010022624,0.034431826,0.000977962,0.0000313252,0.0000049192745,1.8311823e-8,0.004272788,0.000003143299,0.035772294,0.9242738],"study_design_scores_gemma":[0.00050877186,0.00041048264,0.0000034147447,0.04408485,0.0022153552,0.00064040534,0.00001636517,2.445056e-7,0.0013275548,0.000008192351,0.9506403,0.00014403461],"about_ca_topic_score_codex":3.6574494e-7,"about_ca_topic_score_gemma":4.3459032e-8,"teacher_disagreement_score":0.9241297,"about_ca_system_score_codex":0.00001444694,"about_ca_system_score_gemma":0.0009030431,"threshold_uncertainty_score":0.83583826},"labels":[],"label_agreement":null},{"id":"W2908295862","doi":"10.1016/j.ejmech.2018.12.054","title":"Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid","year":2018,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Mental Health; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Institutes of Health","keywords":"Allosteric regulation; NMDA receptor; Chemistry; Potentiator; Allosteric modulator; Schizophrenia (object-oriented programming); Neuroscience; Synaptic plasticity; Glutamate receptor; Neurotransmission; Structure–activity relationship; Receptor; Pharmacology; Stereochemistry; Biochemistry; In vitro; Psychology; Psychiatry; Biology","score_opus":0.1255954388466035,"score_gpt":0.3788367022996097,"score_spread":0.2532412634530062,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2908295862","genre_codex":"empirical","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.80113614,0.19180176,0.00004053956,0.0008645856,0.00297191,0.002064445,0.00033171516,0.00002636432,0.0007625556],"genre_scores_gemma":[0.37741232,0.61746645,0.00025575596,0.00213842,0.0019048344,0.000022765875,0.000008889424,0.00021263864,0.00057788956],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99575007,0.0016934737,0.0008998925,0.00048429167,0.0008491023,0.0003231587],"domain_scores_gemma":[0.9965298,0.0009663892,0.0017401209,0.00027859048,0.0002266161,0.00025846678],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013761198,0.00035601444,0.000785771,0.0001344873,0.00022613212,0.000035286095,0.00096368574,0.000068017835,0.000035946025],"category_scores_gemma":[0.0027039486,0.00021244932,0.00030568673,0.00046824926,0.0013228771,0.00013089484,0.00015671493,0.00083585293,0.0000040964906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003338078,0.000024236333,0.000018514947,0.003031843,0.00003552962,0.00012388469,0.00016743927,0.0000026574105,0.96163243,0.000001242489,0.0007567296,0.033871654],"study_design_scores_gemma":[0.0012394456,0.0015042411,0.00006520792,0.008068772,0.00031575255,0.00036492103,0.000021576963,0.00008845333,0.9728325,0.000020939002,0.015239292,0.0002388723],"about_ca_topic_score_codex":2.5826913e-7,"about_ca_topic_score_gemma":2.1406954e-8,"teacher_disagreement_score":0.42566472,"about_ca_system_score_codex":0.00007641736,"about_ca_system_score_gemma":0.00036402227,"threshold_uncertainty_score":0.8663432},"labels":[],"label_agreement":null},{"id":"W2910345290","doi":"10.1016/j.ejmech.2019.01.040","title":"Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Apelin; Chemistry; Kallikrein; Blood pressure; Biochemistry; Pharmacology; Enzyme; Internal medicine; Receptor","score_opus":0.012464702491527233,"score_gpt":0.2711506614665294,"score_spread":0.25868595897500213,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2910345290","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96651167,0.008351475,0.000046631805,0.0019606485,0.0001616891,0.0002537474,0.00001044266,0.000039637816,0.022664046],"genre_scores_gemma":[0.98479784,0.0026056876,0.0006427123,0.0006080999,0.000990147,0.0000014008007,0.000016266622,0.00008849572,0.010249361],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9956071,0.00021453998,0.0011403268,0.00057910185,0.001751083,0.0007078651],"domain_scores_gemma":[0.99670094,0.00043440802,0.0005748981,0.00043498838,0.00042885065,0.0014259149],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0024207905,0.0004474524,0.0009821183,0.0001879602,0.000108857,0.00007790889,0.0004586616,0.00020060239,0.0015222331],"category_scores_gemma":[0.001987498,0.00033450185,0.00017392996,0.0003026337,0.0004981897,0.00018834248,0.00034067684,0.0021335538,0.000054086475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0027913027,0.000543866,0.004788691,0.0011075007,0.0018625907,0.0054315818,0.00054589804,0.000012602276,0.95985365,0.0000075131966,0.0055991197,0.017455684],"study_design_scores_gemma":[0.045743454,0.0075259786,0.1738294,0.0081330985,0.007439661,0.024997566,0.004174939,0.0017151589,0.50337356,0.00019127363,0.22108819,0.0017877325],"about_ca_topic_score_codex":0.000012205297,"about_ca_topic_score_gemma":3.974038e-7,"teacher_disagreement_score":0.45648012,"about_ca_system_score_codex":0.000042751682,"about_ca_system_score_gemma":0.0003313659,"threshold_uncertainty_score":0.9999107},"labels":[],"label_agreement":null},{"id":"W2910705150","doi":"10.1016/j.ejmech.2019.01.009","title":"Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs)","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; In vitro; In vivo; Biochemistry; Pharmacology; Biology; Genetics","score_opus":0.007039991667387906,"score_gpt":0.2184948570244195,"score_spread":0.2114548653570316,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2910705150","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99476653,0.0046000546,0.000065112334,0.00006843482,0.00012889874,0.00009778937,0.000024928577,0.000002243097,0.00024602452],"genre_scores_gemma":[0.99541074,0.0038954045,0.00020757913,0.000026677199,0.00034472687,9.0443643e-7,0.0000361031,0.000016792586,0.00006108272],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987447,0.00018773356,0.00052517233,0.00021113083,0.00016519855,0.00016606704],"domain_scores_gemma":[0.9990543,0.00007709477,0.0005196472,0.00012948553,0.00011278652,0.0001066715],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007049077,0.0001625928,0.00044702218,0.00006510882,0.000015385724,0.0000050164494,0.00012752712,0.0000776622,0.000014091264],"category_scores_gemma":[0.00038296246,0.00013677138,0.00006623119,0.000095748226,0.00022294544,0.000010657927,0.000056064753,0.00017572638,4.052507e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028379178,0.000048978556,0.0005975966,0.00013576455,0.000086087326,0.00002605262,0.000091221096,0.000003978345,0.9863116,5.298471e-7,0.000029947398,0.00983034],"study_design_scores_gemma":[0.0017515247,0.0006051869,0.052042753,0.00017873234,0.00006907617,0.0003922033,0.00017849011,0.000009533414,0.94395804,0.0000020903103,0.00069321715,0.00011915406],"about_ca_topic_score_codex":0.0000020732416,"about_ca_topic_score_gemma":1.3557751e-7,"teacher_disagreement_score":0.051445156,"about_ca_system_score_codex":0.000013493773,"about_ca_system_score_gemma":0.000077003075,"threshold_uncertainty_score":0.5577375},"labels":[],"label_agreement":null},{"id":"W2911947907","doi":"10.1016/j.ejmech.2019.02.046","title":"Challenges and current status of computational methods for docking small molecules to nucleic acids","year":2019,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Genome Canada","keywords":"Nucleic acid; Docking (animal); Chemistry; In silico; Small molecule; Computational biology; Drug discovery; RNA; Nucleic acid structure; Biochemistry; Biology","score_opus":0.08951594543874189,"score_gpt":0.3867281771411668,"score_spread":0.29721223170242494,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2911947907","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0011570527,0.98899627,0.007502575,0.000033338627,0.00024173065,0.00018193634,0.000041736384,0.0000041764956,0.0018411712],"genre_scores_gemma":[0.00035057619,0.9740405,0.024432719,0.000027130787,0.0009007944,0.000003620144,0.00009756125,0.00008612323,0.000060959286],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9978055,0.00022420239,0.0009918553,0.0004078797,0.0002332703,0.00033733042],"domain_scores_gemma":[0.9978046,0.00014093782,0.0010718196,0.00030854964,0.00030711727,0.00036698484],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001143329,0.0003995079,0.0011526928,0.00006605188,0.000032872176,0.000015398853,0.00049944676,0.00014268543,0.000010143005],"category_scores_gemma":[0.00053821784,0.00033102438,0.0004450863,0.00006060789,0.00011692997,0.0000037012112,0.00023653393,0.00040540032,0.0000016800379],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000075475305,0.00004964728,0.0000014396244,0.017106619,0.00026982356,0.0000132089,0.000081182385,0.000017955923,0.009833836,0.000003820272,0.0003320102,0.972215],"study_design_scores_gemma":[0.00071772817,0.00040454365,0.000011140105,0.008042621,0.000638237,0.00039475213,0.000111318834,0.0000073402944,0.0050761425,0.000022067708,0.98425746,0.00031666885],"about_ca_topic_score_codex":1.3927017e-7,"about_ca_topic_score_gemma":4.2481105e-8,"teacher_disagreement_score":0.9839254,"about_ca_system_score_codex":0.000037874284,"about_ca_system_score_gemma":0.00032679693,"threshold_uncertainty_score":0.99991417},"labels":[],"label_agreement":null},{"id":"W2912186110","doi":"10.1016/j.ejmech.2019.01.052","title":"New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Cancéropôle Grand Ouest; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Région Bretagne; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Chinesisch-Deutsche Zentrum für Wissenschaftsförderung; University of Carthage; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Deutsche Forschungsgemeinschaft; Infrastructures en Biologie Santé et Agronomie; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Ontario Genomics; Pfizer","keywords":"DYRK1A; Chemistry; Quinazoline; Kinase; Casein kinase 1; Threonine; Phosphorylation; Biochemistry; Stereochemistry; Protein kinase A; Serine","score_opus":0.01937670700912855,"score_gpt":0.28105914151830474,"score_spread":0.2616824345091762,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2912186110","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9839202,0.001667896,0.00031819785,0.0007134137,0.000030495097,0.000053239008,0.00000931188,0.00001910002,0.01326811],"genre_scores_gemma":[0.99737245,0.00054387125,0.00090115174,0.000038818496,0.0007646958,0.0000022762008,0.000014122502,0.000025092373,0.00033755033],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99810296,0.0001169056,0.00068624533,0.00034122553,0.0005253741,0.00022727146],"domain_scores_gemma":[0.99825007,0.00033715597,0.00063472235,0.00026203424,0.00017718336,0.00033884597],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0013931808,0.00024151648,0.0004975441,0.00010056739,0.00009459885,0.000056577792,0.00025687908,0.00008258814,0.0021236734],"category_scores_gemma":[0.00072620163,0.00018736567,0.00014871267,0.0002446611,0.00013221454,0.00011821718,0.00009802671,0.00039878313,0.000019745643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012471105,0.00007081919,0.009114928,0.000106526415,0.0004348421,0.000039808136,0.00032029205,0.00005641209,0.95438796,0.000024526818,0.00036249467,0.034956686],"study_design_scores_gemma":[0.0025768415,0.00020049125,0.011399385,0.0010391282,0.0023925367,0.00087201357,0.0037173387,0.001956782,0.9676194,0.00030286217,0.0072383373,0.0006848691],"about_ca_topic_score_codex":0.000008193196,"about_ca_topic_score_gemma":3.5591364e-7,"teacher_disagreement_score":0.034271818,"about_ca_system_score_codex":0.000061738465,"about_ca_system_score_gemma":0.000109807515,"threshold_uncertainty_score":0.99878854},"labels":[],"label_agreement":null},{"id":"W2914347737","doi":"10.1016/j.ejmech.2019.02.006","title":"Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Fundação para a Ciência e a Tecnologia; Ontario Mental Health Foundation; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"Chemistry; Caffeic acid; Caffeic acid phenethyl ester; Docking (animal); Stereochemistry; Steric effects; Polyphenol; Combinatorial chemistry; Biochemistry; Antioxidant","score_opus":0.014431984835034873,"score_gpt":0.2628734358722973,"score_spread":0.2484414510372624,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2914347737","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9808351,0.016328884,0.00013262431,0.00012983645,0.000053424643,0.00033744524,0.000010453824,0.00001583583,0.002156387],"genre_scores_gemma":[0.9982803,0.0005592821,0.000744338,0.00006166736,0.00023253614,0.0000027648887,0.000020927277,0.000057283996,0.00004092638],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99722207,0.00034077282,0.00086371275,0.0003165479,0.00091393077,0.0003429794],"domain_scores_gemma":[0.9974536,0.00017555534,0.0010149367,0.0003351568,0.00054548844,0.0004753145],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00097650394,0.00032179238,0.0008132791,0.00016305457,0.000056721474,0.000017673015,0.00020104603,0.00007326489,0.000096579766],"category_scores_gemma":[0.0005726299,0.00025028744,0.0002046361,0.00023942963,0.00039388705,0.00021543312,0.00010549668,0.0005579971,0.000009210331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001994392,0.00026067745,0.02807887,0.0010005872,0.0021557917,0.0007117975,0.0006476744,0.000003477742,0.9574641,8.5428417e-7,0.000045370172,0.0076364093],"study_design_scores_gemma":[0.00650011,0.0016578303,0.05743926,0.0035365452,0.00072769914,0.00092677004,0.0009061594,0.000016398972,0.9280658,0.00003076401,0.000026695747,0.00016598738],"about_ca_topic_score_codex":0.000008356816,"about_ca_topic_score_gemma":2.7525118e-7,"teacher_disagreement_score":0.029398317,"about_ca_system_score_codex":0.00011873713,"about_ca_system_score_gemma":0.00027911662,"threshold_uncertainty_score":0.99999493},"labels":[],"label_agreement":null},{"id":"W2938136921","doi":"10.1016/j.ejmech.2019.04.034","title":"Heterodimeric Rifampicin–Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pseudomonas aeruginosa; Efflux; Tobramycin; Chloramphenicol; Doxycycline; Microbiology; In vivo; Antibiotics; Chemistry; Rifampicin; Aminoglycoside; Antibacterial agent; Membrane permeability; Pyocyanin; Pharmacology; Bacteria; Biology; Biofilm; Gentamicin; Biochemistry; Quorum sensing; Membrane","score_opus":0.006255366409287122,"score_gpt":0.22369633226034882,"score_spread":0.2174409658510617,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2938136921","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99701005,0.0014391346,0.00008407123,0.00021473081,0.000055841407,0.00015956892,0.000009109317,0.000001980997,0.0010255189],"genre_scores_gemma":[0.99724424,0.00067804556,0.001575386,0.00013496923,0.000102909326,7.864281e-7,0.000004750524,0.000028468728,0.00023047236],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9981668,0.00014142705,0.00086827716,0.0003444675,0.0002160348,0.0002629666],"domain_scores_gemma":[0.9990825,0.000045406632,0.00037536392,0.0002624395,0.00007859079,0.00015569758],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009547625,0.00022348097,0.00052495016,0.00010698215,0.000011310465,0.000015662537,0.00025416512,0.00008263476,0.000021560276],"category_scores_gemma":[0.00020924202,0.00020600682,0.000048384667,0.0001669252,0.00016012366,0.000012865146,0.0001282202,0.00030175757,9.842366e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00307132,0.000075520795,0.024515674,0.00021637134,0.000018885463,0.00014925796,0.00021224961,0.00017384157,0.97116655,0.0000010896464,0.00011035436,0.0002888787],"study_design_scores_gemma":[0.0049329638,0.00030952995,0.03593546,0.0011825982,0.000020273501,0.00020877465,0.0005029951,0.00021261263,0.9557256,0.00003197554,0.00061722874,0.00031998163],"about_ca_topic_score_codex":0.000009154104,"about_ca_topic_score_gemma":0.000025179934,"teacher_disagreement_score":0.015440952,"about_ca_system_score_codex":0.000035841862,"about_ca_system_score_gemma":0.00008470866,"threshold_uncertainty_score":0.84007144},"labels":[],"label_agreement":null},{"id":"W2943708726","doi":"10.1016/j.ejmech.2019.05.003","title":"Amphiphilic nebramine-based hybrids Rescue legacy antibiotics from intrinsic resistance in multidrug-resistant Gram-negative bacilli","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council","keywords":"Tobramycin; Antibiotics; Pseudomonas aeruginosa; Microbiology; Multiple drug resistance; Rifampicin; Aminoglycoside; Chemistry; Rifamycin; Bacteria; Biology; Gentamicin; Genetics","score_opus":0.007482033288750078,"score_gpt":0.22291667707586674,"score_spread":0.21543464378711666,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2943708726","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9931144,0.0013715014,0.00056209054,0.00040424181,0.00038314992,0.00016087716,0.000045830362,0.00001140992,0.003946485],"genre_scores_gemma":[0.9926646,0.00017031966,0.0051920637,0.0002413475,0.0009258101,1.9818434e-7,0.00007961999,0.00007686544,0.0006491926],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99691904,0.00037500728,0.0011177987,0.0005467535,0.00058673247,0.00045468909],"domain_scores_gemma":[0.9978714,0.00012431521,0.0006954327,0.0007368881,0.00030672448,0.00026524035],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001105558,0.0003984977,0.00057906826,0.000090821166,0.000055248933,0.00006871972,0.0007997271,0.00012785487,0.00014546626],"category_scores_gemma":[0.0007669277,0.0003580903,0.0002188014,0.00023801185,0.00033831326,0.000026805621,0.00012399082,0.00065613334,0.00002899691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0021276495,0.00017046896,0.016418794,0.00019430937,0.00010382163,0.0010073048,0.000097761345,0.00010379319,0.9777209,0.000007385311,0.0011343308,0.0009134775],"study_design_scores_gemma":[0.007887714,0.0006528525,0.14034373,0.0021192369,0.00009927032,0.00010069773,0.00075493346,0.000058053414,0.8220557,0.000053834712,0.025099875,0.0007741045],"about_ca_topic_score_codex":0.00002447934,"about_ca_topic_score_gemma":0.000042917218,"teacher_disagreement_score":0.1556652,"about_ca_system_score_codex":0.000116610965,"about_ca_system_score_gemma":0.00030447225,"threshold_uncertainty_score":0.9998871},"labels":[],"label_agreement":null},{"id":"W2943865470","doi":"10.1016/j.ejmech.2019.04.074","title":"Organoseleno cytostatic derivatives: Autophagic cell death with AMPK and JNK activation","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Cancer Institute; Universidad Nacional de Educación a Distancia; Asociación de Amigos de la Universidad de Navarra; “la Caixa” Foundation; Universidad de Navarra; Calgary Foundation","keywords":"Autophagy; Chemistry; Wortmannin; Programmed cell death; Imide; AMPK; Cell culture; Apoptosis; Amide; Cell cycle checkpoint; Selectivity; Stereochemistry; Cancer research; Cell cycle; Biochemistry; PI3K/AKT/mTOR pathway; Kinase; Catalysis; Organic chemistry; Protein kinase A","score_opus":0.005329260554480915,"score_gpt":0.19833667651633446,"score_spread":0.19300741596185356,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2943865470","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9903542,0.0005053043,0.001849614,0.00012947712,0.00004358715,0.000075010255,0.0000042089705,0.000004478765,0.0070341374],"genre_scores_gemma":[0.99668914,0.0001641435,0.0018278612,0.0002095606,0.00044299953,5.207704e-7,0.000023970024,0.00003478971,0.00060699845],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989719,0.00008252636,0.0003129392,0.00023462366,0.00021229981,0.00018572806],"domain_scores_gemma":[0.999038,0.000028695538,0.0003921051,0.00019536314,0.00018293879,0.00016294303],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028912257,0.00018937785,0.00022271067,0.000025645022,0.00004043875,0.000020181556,0.00021603178,0.000044240165,0.000075755466],"category_scores_gemma":[0.00009432128,0.00014700055,0.00004724137,0.0000558414,0.00010891989,0.000010648085,0.000063314335,0.0002499593,0.0000070654305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025687148,0.000047422534,0.003770466,0.00012676461,0.000056271398,0.00003377178,0.0002447266,0.000017117274,0.99453145,0.0000015866144,0.00041434506,0.00049923046],"study_design_scores_gemma":[0.0018553946,0.0006758878,0.007116894,0.00015815679,0.000038509035,0.00019551461,0.0007993372,0.000008405253,0.9862679,0.000017771643,0.0026842125,0.0001819886],"about_ca_topic_score_codex":7.0130454e-7,"about_ca_topic_score_gemma":8.7117e-8,"teacher_disagreement_score":0.008263498,"about_ca_system_score_codex":0.000021178059,"about_ca_system_score_gemma":0.00010123259,"threshold_uncertainty_score":0.5994509},"labels":[],"label_agreement":null},{"id":"W2945911027","doi":"10.1016/j.ejmech.2019.05.041","title":"C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Novartis Pharma; Ministero dello Sviluppo Economico; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; National Institute for Health and Care Research; Diamond Light Source; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Avon Foundation for Women; Merck KGaA; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Royal Marsden NHS Foundation Trust; Pfizer","keywords":"Chemistry; Subfamily; Demethylase; Histone; Stereochemistry; Acetylation; Enzyme; Lysine; Biochemistry; Substituent; Amino acid","score_opus":0.025699290856347434,"score_gpt":0.278359716301801,"score_spread":0.2526604254454536,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2945911027","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97613496,0.017103394,0.0044239624,0.00022386601,0.00037045154,0.00024103413,0.0000114754275,0.000005562452,0.0014852823],"genre_scores_gemma":[0.99659604,0.0009411143,0.001772669,0.00005968744,0.00040549887,0.0000034351451,0.000090792295,0.000039378352,0.000091363494],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9967711,0.00059625175,0.0014122627,0.00033526492,0.00061152136,0.00027359018],"domain_scores_gemma":[0.99754494,0.00010145211,0.0013571033,0.0003838151,0.0004945581,0.000118101976],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005551269,0.00027593633,0.0004435741,0.00009647726,0.00010247066,0.00002471725,0.00042163552,0.00008222804,0.000011961301],"category_scores_gemma":[0.0003454923,0.00021299129,0.00018022243,0.00018806782,0.00019514021,0.000013250019,0.00009636947,0.00047514652,0.000002805911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036895522,0.00018732257,0.003350681,0.00035397007,0.00007863491,0.000086681306,0.00039267397,0.0050524143,0.98961633,0.0000015786778,0.00009714866,0.00041360763],"study_design_scores_gemma":[0.0028125416,0.00042630726,0.0028292045,0.00022257028,0.00010532182,0.000015159699,0.0024251067,0.00025949013,0.9890409,0.000022082484,0.0016286331,0.0002126875],"about_ca_topic_score_codex":0.0000073195797,"about_ca_topic_score_gemma":0.0000013653834,"teacher_disagreement_score":0.02046109,"about_ca_system_score_codex":0.00010681567,"about_ca_system_score_gemma":0.00025878544,"threshold_uncertainty_score":0.8685533},"labels":[],"label_agreement":null},{"id":"W2947492162","doi":"10.1016/j.ejmech.2019.05.064","title":"Tetrahydropyrazolo[1,5-a]pyridine-fused steroids and their in vitro biological evaluation in prostate cancer","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"European Regional Development Fund; Fundação para a Ciência e a Tecnologia; Univerzita Palackého v Olomouci","keywords":"Chemistry; Prostate cancer; In vitro; Biological activity; Pyridine; Cancer; Combinatorial chemistry; Prostate; Pharmacology; Stereochemistry; Biochemistry; Internal medicine; Medicinal chemistry","score_opus":0.009243791975249075,"score_gpt":0.2431221830917179,"score_spread":0.23387839111646883,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2947492162","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9900747,0.008323264,0.000004936876,0.00019760126,0.00011033457,0.00013107045,0.0000033397816,0.0000023877606,0.0011523783],"genre_scores_gemma":[0.99839956,0.0012038028,0.000041969473,0.00008336275,0.00017207558,0.0000020808948,0.000017322363,0.000016355212,0.00006347224],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988497,0.00022119758,0.00036826427,0.0002028437,0.00016757674,0.00019042585],"domain_scores_gemma":[0.99949884,0.00002190524,0.00018700317,0.00012125105,0.00007304543,0.000097940785],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014334106,0.00015075404,0.00022136114,0.0000395696,0.000014259316,0.000009744891,0.00015094981,0.00007363674,0.0000313117],"category_scores_gemma":[0.000114597104,0.000101708094,0.00005406383,0.00009164848,0.00007913457,0.0000061730943,0.00005334622,0.00039470725,0.0000028202921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00064274366,0.00004824233,0.01069065,0.000032090735,0.000028399905,0.00009144988,0.00016442944,0.00013881165,0.97833365,1.08307724e-7,0.00006996322,0.009759442],"study_design_scores_gemma":[0.004820141,0.0006258829,0.014912434,0.00025694448,0.000019200354,0.00036429256,0.00042771574,0.00047938063,0.97666395,0.000009461244,0.0012405979,0.00018002294],"about_ca_topic_score_codex":0.0000027415726,"about_ca_topic_score_gemma":5.076602e-7,"teacher_disagreement_score":0.009579419,"about_ca_system_score_codex":0.000036249316,"about_ca_system_score_gemma":0.000091125636,"threshold_uncertainty_score":0.41475356},"labels":[],"label_agreement":null},{"id":"W2949795865","doi":"10.1016/j.ejmech.2011.12.006","title":"Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":72,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ebselen; Chemistry; Kinase; In vivo; In vitro; Cancer; Protein kinase B; Cancer research; Cancer cell; Biological activity; Pharmacology; Metastasis; Biochemistry; Signal transduction; Biology; Enzyme; Medicine; Internal medicine","score_opus":0.12241606529758538,"score_gpt":0.3688937914066009,"score_spread":0.24647772610901553,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2949795865","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99668276,0.002406235,0.00017735819,0.000121771445,0.00008262795,0.00007403673,0.00004945202,0.000010997637,0.00039475312],"genre_scores_gemma":[0.99628055,0.00071070774,0.0026949006,0.000055676,0.0002221805,0.000001663241,0.0000014372637,0.000022558235,0.000010303008],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99852276,0.0002656074,0.0005708054,0.00021195906,0.00018900848,0.00023985906],"domain_scores_gemma":[0.9981378,0.0005449686,0.0007280101,0.00008076426,0.00021944245,0.0002890594],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012862652,0.00020948105,0.0004692588,0.000049647122,0.00008847786,0.0000048197057,0.00019057351,0.00010297798,0.00041126207],"category_scores_gemma":[0.0016017499,0.0001593693,0.000060509974,0.00013973413,0.0004521747,0.00007928538,0.00015684066,0.0005160333,4.263941e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00076458324,0.00034112026,0.028680049,0.00045945714,0.0001250655,0.0000655338,0.0011160912,0.0000044194994,0.95934695,7.459845e-7,0.00009491421,0.009001066],"study_design_scores_gemma":[0.0010883037,0.0002200531,0.00844688,0.00051466585,0.00018695122,0.00015526432,0.0008370626,0.000017648443,0.9881461,0.000002436443,0.00023607019,0.00014853365],"about_ca_topic_score_codex":0.000010967091,"about_ca_topic_score_gemma":4.0982638e-7,"teacher_disagreement_score":0.028799176,"about_ca_system_score_codex":0.000020392286,"about_ca_system_score_gemma":0.00007732995,"threshold_uncertainty_score":0.6498891},"labels":[],"label_agreement":null},{"id":"W2951510058","doi":"10.1016/j.ejmech.2019.06.060","title":"Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; New Brunswick Innovation Foundation; Canada Foundation for Innovation","keywords":"Chemistry; Cancer cell; Apoptosis; Autophagy; Arachidonate 5-lipoxygenase; Programmed cell death; Enzyme inhibitor; Cell culture; Lipoxygenase; Cancer research; Biochemistry; Viability assay; Cancer; Enzyme; Arachidonic acid; Biology","score_opus":0.01193918689554804,"score_gpt":0.242185368101797,"score_spread":0.23024618120624896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2951510058","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9964904,0.001661608,0.000061315804,0.00038087735,0.0004653397,0.00019348106,0.00001765411,0.000012131349,0.00071718567],"genre_scores_gemma":[0.9982382,0.000094472016,0.00017118403,0.00026532199,0.0008219071,0.0000022102643,0.0000082997685,0.0000508805,0.00034754685],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99769866,0.00013268794,0.000824783,0.00027563778,0.000725573,0.00034267665],"domain_scores_gemma":[0.9984264,0.00012429277,0.00073467277,0.00026937103,0.00012907019,0.000316209],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014996541,0.00030985914,0.00075316813,0.000191481,0.000028329343,0.000019531208,0.00020761233,0.0000980373,0.00017863626],"category_scores_gemma":[0.00013205719,0.0002303123,0.0001846274,0.00019991404,0.00018178386,0.00018644413,0.000057477726,0.00078991224,0.0000068425566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009998038,0.00022683151,0.006117291,0.0012218398,0.000095013456,0.0005169398,0.0003571384,0.00009701017,0.98902583,5.34813e-7,0.000577058,0.00076470076],"study_design_scores_gemma":[0.008420735,0.0006561184,0.01024671,0.0037354382,0.00018257089,0.00024942504,0.0002884962,0.00043831722,0.97536474,9.214971e-7,0.00021144448,0.00020507298],"about_ca_topic_score_codex":0.00001598198,"about_ca_topic_score_gemma":8.908497e-7,"teacher_disagreement_score":0.013661088,"about_ca_system_score_codex":0.00014731675,"about_ca_system_score_gemma":0.00047702465,"threshold_uncertainty_score":0.93918633},"labels":[],"label_agreement":null},{"id":"W2955530568","doi":"10.1016/j.ejmech.2019.06.090","title":"Second-generation testosterone-platinum(II) hybrids for site-specific treatment of androgen receptor positive prostate cancer: Design, synthesis and antiproliferative activity","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"DU145; LNCaP; Prostate cancer; Androgen receptor; Chemistry; Testosterone (patch); Cancer research; Cancer; HaCaT; Androgen; Dihydrotestosterone; Endocrinology; Internal medicine; Biology; Hormone; Biochemistry; Medicine; In vitro","score_opus":0.051254725189913794,"score_gpt":0.26141628223026225,"score_spread":0.21016155704034845,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2955530568","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993596,0.004191503,0.00018601364,0.0004136519,0.00010383903,0.00046494737,0.00009993761,0.0000066056973,0.00093749847],"genre_scores_gemma":[0.9953882,0.0009582099,0.0017817888,0.000038028,0.0005429646,0.000010073482,0.000012175915,0.000034446206,0.0012340788],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99861646,0.00021652858,0.00049414404,0.00022870573,0.00027085992,0.00017332399],"domain_scores_gemma":[0.9985796,0.00024713055,0.0005359016,0.00015957096,0.0003199418,0.0001578343],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006861115,0.00022254497,0.00064532453,0.00004960152,0.000090221554,0.00001794994,0.00007008429,0.00003302408,0.00037853263],"category_scores_gemma":[0.0001237449,0.00015051392,0.0001265281,0.000055176024,0.000105679224,0.000092931325,0.000021664893,0.00012833398,0.0000032703142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.003252116,0.00016827144,0.0016755544,0.00024449936,0.00022180886,0.000027606628,0.0012920683,0.00001019685,0.9617682,5.595399e-7,0.00065694016,0.030682154],"study_design_scores_gemma":[0.0022367733,0.004270532,0.0022731705,0.00064128224,0.00022627001,0.00032091653,0.00018105491,0.00013107179,0.9849638,0.0000017492201,0.004616126,0.00013725794],"about_ca_topic_score_codex":0.0000027581495,"about_ca_topic_score_gemma":4.412289e-7,"teacher_disagreement_score":0.030544896,"about_ca_system_score_codex":0.00009862966,"about_ca_system_score_gemma":0.00014135086,"threshold_uncertainty_score":0.613778},"labels":[],"label_agreement":null},{"id":"W2963367782","doi":"10.1016/j.ejmech.2019.07.063","title":"Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Higher Education Commision, Pakistan; University of Sharjah; Crohn's and Colitis Canada; American University of Sharjah; University of Saskatchewan","keywords":"Chemistry; Docking (animal); Potency; Phosphodiesterase; IC50; Stereochemistry; Biochemistry; Enzyme; Pharmacology; In vitro","score_opus":0.05030044355069716,"score_gpt":0.32279883863522174,"score_spread":0.27249839508452456,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2963367782","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99015135,0.008333721,0.000008978406,0.00055974716,0.00018904287,0.00017836252,0.000008335403,0.000010667435,0.00055978337],"genre_scores_gemma":[0.99680334,0.0023763953,0.00033846364,0.00009835814,0.00017454984,0.0000012011617,0.000003655564,0.000022986009,0.00018106615],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978335,0.00018604584,0.0009683942,0.00021692963,0.00062005804,0.00017509425],"domain_scores_gemma":[0.9977193,0.00038103177,0.00096188526,0.00020193792,0.000482717,0.00025313778],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013389571,0.0002297008,0.0007734342,0.00007869217,0.000040775103,0.000008034724,0.00011893878,0.000040156512,0.00033267424],"category_scores_gemma":[0.002476323,0.00014289202,0.00012855456,0.00016135884,0.000254424,0.00007953754,0.00007525674,0.00024258044,0.000007396517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0042521986,0.00025798485,0.02023295,0.00074289006,0.0008719229,0.0011519803,0.0012497696,0.000038826052,0.9441495,0.0000052099126,0.00048103312,0.026565751],"study_design_scores_gemma":[0.005322815,0.0018213495,0.048764437,0.0030358164,0.0005213958,0.0014536838,0.0027378183,0.000019752626,0.9352199,0.000034215554,0.00091681525,0.00015200856],"about_ca_topic_score_codex":0.0000071044424,"about_ca_topic_score_gemma":2.8847063e-7,"teacher_disagreement_score":0.02853149,"about_ca_system_score_codex":0.00008421731,"about_ca_system_score_gemma":0.00022943939,"threshold_uncertainty_score":0.58269674},"labels":[],"label_agreement":null},{"id":"W2964894061","doi":"10.1016/j.ejmech.2019.111586","title":"Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Carbonic anhydrase; Moiety; Stereochemistry; Enzyme; In vitro; Sulfonamide; Chemical synthesis; Ring (chemistry); Viability assay; Biochemistry; Organic chemistry","score_opus":0.00615513026259965,"score_gpt":0.20468434630133245,"score_spread":0.1985292160387328,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2964894061","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9870046,0.00025545838,0.0003564775,0.0001107991,0.0001286691,0.000049931772,0.000006141848,0.000005488696,0.012082449],"genre_scores_gemma":[0.9985601,0.00008661506,0.0002819418,0.00007240973,0.00054076116,4.529132e-7,0.0000062992535,0.000029689647,0.0004217635],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988791,0.00005832023,0.00035651366,0.00019933877,0.00034281367,0.00016391378],"domain_scores_gemma":[0.9989197,0.000029830418,0.0004919409,0.00023174984,0.0001878199,0.00013895927],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006101657,0.00016416321,0.00024625487,0.000037525868,0.00003333219,0.000010648474,0.00016537262,0.000051961153,0.00007944355],"category_scores_gemma":[0.0002531877,0.00012990551,0.00012607398,0.00008625407,0.00011039978,0.000012902497,0.000055706845,0.0002738682,0.0000047077538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00051173574,0.00012591691,0.0017219665,0.000114396316,0.00007621018,0.000066856126,0.000027176065,0.00021725362,0.9959672,0.0000014655209,0.00041858587,0.00075122854],"study_design_scores_gemma":[0.0011958453,0.00063634693,0.0020537905,0.00049544545,0.00006291754,0.00081004953,0.0002082226,0.000032384385,0.9925821,7.4274345e-7,0.001779,0.00014319843],"about_ca_topic_score_codex":0.0000071369413,"about_ca_topic_score_gemma":7.2540854e-7,"teacher_disagreement_score":0.011660686,"about_ca_system_score_codex":0.000025211628,"about_ca_system_score_gemma":0.00013723379,"threshold_uncertainty_score":0.52973926},"labels":[],"label_agreement":null},{"id":"W2965626949","doi":"10.1016/j.ejmech.2019.111567","title":"Discovery of β-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Natural Science Foundation of Guangxi Province; National Natural Science Foundation of China","keywords":"Chemistry; In vivo; In vitro; Apoptosis; Cytotoxicity; Cisplatin; Cancer research; Structure–activity relationship; Cancer cell; Pharmacology; Cancer; Stereochemistry; Biochemistry; Chemotherapy; Internal medicine; Biology","score_opus":0.011962221029918164,"score_gpt":0.24410018221610236,"score_spread":0.23213796118618418,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2965626949","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99641603,0.002159621,0.000008720422,0.00030731497,0.000048184906,0.00005590702,0.0000145350705,8.8395814e-7,0.0009887996],"genre_scores_gemma":[0.99855596,0.0009989303,0.00006192781,0.00005414515,0.000192228,5.9193206e-7,0.0000017351625,0.000014151945,0.0001203571],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990051,0.00010104909,0.00034834695,0.000201963,0.00018260887,0.00016096466],"domain_scores_gemma":[0.9995224,0.0000334359,0.00021931375,0.00011844133,0.00003670162,0.00006973641],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00063944823,0.00014217445,0.00034738932,0.00006083697,0.00001272513,0.00000974403,0.00012339285,0.00005997676,0.00000998267],"category_scores_gemma":[0.00007383104,0.0001196297,0.000046188874,0.00006530825,0.00013493079,0.000023945808,0.000113387,0.00024832322,1.2797484e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001364709,0.0001255915,0.01063978,0.000111233465,0.000018982828,0.00004148099,0.00010332348,0.00004621426,0.98602664,3.7428975e-7,0.000038608214,0.0014830846],"study_design_scores_gemma":[0.0018150678,0.00022789493,0.018062467,0.00045891,0.000011264392,0.000090828406,0.00022864804,0.000112138725,0.97869337,0.000012263847,0.00016382722,0.00012333745],"about_ca_topic_score_codex":0.0000656163,"about_ca_topic_score_gemma":0.000032574164,"teacher_disagreement_score":0.0074226856,"about_ca_system_score_codex":0.000026132697,"about_ca_system_score_gemma":0.00008102175,"threshold_uncertainty_score":0.48783576},"labels":[],"label_agreement":null},{"id":"W2973005468","doi":"10.1016/j.ejmech.2019.111693","title":"New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":69,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Western Canada Research Grid; Compute Canada","keywords":"Chemistry; ADME; Erlotinib; In silico; Cytotoxicity; Pharmacology; MTT assay; In vitro; Stereochemistry; Biochemistry; Epidermal growth factor receptor","score_opus":0.035450126800548855,"score_gpt":0.2635439963571558,"score_spread":0.22809386955660696,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2973005468","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9942819,0.0025994128,0.00005585304,0.00025949095,0.000027572463,0.000075219614,0.0000019722434,0.000011530932,0.0026870726],"genre_scores_gemma":[0.9987247,0.00038996158,0.00033600887,0.000029725594,0.00041662497,0.0000019956774,4.2808745e-7,0.000018089659,0.00008245993],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99836403,0.00030473547,0.0003399719,0.00029521322,0.00048115416,0.00021490279],"domain_scores_gemma":[0.9983181,0.00081160385,0.0003967029,0.00012928246,0.00015345358,0.00019087938],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021851524,0.0002336169,0.0004905202,0.000042222695,0.000053518,0.000026604372,0.00011767652,0.00007091972,0.0001801489],"category_scores_gemma":[0.001055568,0.00015339095,0.000044921962,0.00009059016,0.00016743575,0.00015171153,0.00006910902,0.00053047936,0.000002174798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000957791,0.00009345505,0.017796159,0.00018293761,0.00012684015,0.0001327506,0.0002520293,0.00001556914,0.93625873,2.6726335e-7,0.00013443847,0.04404903],"study_design_scores_gemma":[0.0015935041,0.00022853467,0.04926974,0.0010056489,0.0001335452,0.00061517104,0.0010336235,0.00008138726,0.9456805,0.000029429932,0.000106569496,0.00022234528],"about_ca_topic_score_codex":0.0000051034813,"about_ca_topic_score_gemma":0.0000022450554,"teacher_disagreement_score":0.043826684,"about_ca_system_score_codex":0.00013870522,"about_ca_system_score_gemma":0.00014836424,"threshold_uncertainty_score":0.62551016},"labels":[],"label_agreement":null},{"id":"W2973226651","doi":"10.1016/j.ejmech.2019.111687","title":"Recent advances in α,β-unsaturated carbonyl compounds as mitochondrial toxins","year":2019,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis of heterocyclic compounds","field":"Chemistry","cited_by":87,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Mitochondrion; Cytotoxic T cell; Organelle; Conjugated system; Cytotoxicity; Toxicity; Biochemistry; In vitro; Organic chemistry","score_opus":0.03409391546560629,"score_gpt":0.3075493383903256,"score_spread":0.2734554229247193,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2973226651","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0005357129,0.87526685,0.0000027000253,0.0000816297,0.0012789782,0.00011199189,0.000024319508,0.000038463,0.12265936],"genre_scores_gemma":[0.00044010457,0.9933448,0.000112622714,0.000043647877,0.0044861143,0.000004301247,0.00006119002,0.00020594076,0.0013013214],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9938838,0.00042082233,0.0029790164,0.0006935137,0.001344368,0.0006784632],"domain_scores_gemma":[0.9946081,0.0007497959,0.0029798995,0.00093804376,0.00025207558,0.00047208118],"candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001024037,0.0009946513,0.0033586083,0.00023558123,0.00006253878,0.00009358923,0.0021036363,0.0003492272,0.0023065817],"category_scores_gemma":[0.0010776657,0.00080513716,0.0009479026,0.0003641602,0.00021326906,0.0002148388,0.00024665645,0.0031823546,0.00015447283],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020602581,0.00016557459,0.0000049641685,0.013724219,0.00027649177,0.0029655846,0.00007948246,0.000003980658,0.0036181621,4.6009708e-7,0.0018210985,0.9771339],"study_design_scores_gemma":[0.0015917576,0.00008986859,0.0000012205628,0.04270706,0.0007811178,0.0050399853,0.00015097376,0.0000025555416,0.0011108089,0.0000061198984,0.94786745,0.00065106904],"about_ca_topic_score_codex":0.0000020625732,"about_ca_topic_score_gemma":0.0000013654907,"teacher_disagreement_score":0.97648287,"about_ca_system_score_codex":0.0007801906,"about_ca_system_score_gemma":0.00085784163,"threshold_uncertainty_score":0.99943995},"labels":[],"label_agreement":null},{"id":"W2978799523","doi":"10.1016/j.ejmech.2019.111754","title":"Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Université de Sherbrooke; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Centre de recherche du CHU Sainte-Justine; Crohn's and Colitis Canada","keywords":"Chemistry; Scaffold; Uracil; Structure–activity relationship; Phosphate; Stereochemistry; Biochemistry; In vitro; DNA","score_opus":0.012404540469919784,"score_gpt":0.24787423909635606,"score_spread":0.23546969862643627,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2978799523","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99543005,0.00065329927,0.00033079486,0.00010701179,0.00021586762,0.0001071689,0.000006647891,0.00000521547,0.0031439546],"genre_scores_gemma":[0.998443,0.000010661091,0.00022339415,0.00009485243,0.0007855985,4.2178488e-7,0.000010740051,0.000034707104,0.00039660212],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99814785,0.0003216884,0.0005528358,0.00026088007,0.00053020776,0.00018654941],"domain_scores_gemma":[0.9984579,0.000096731725,0.00069407385,0.00038989502,0.00020329522,0.00015809106],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011087387,0.00021658414,0.00031379823,0.00005761172,0.000052733987,0.00001265185,0.00031954507,0.00007762383,0.00015848517],"category_scores_gemma":[0.000376865,0.00017775437,0.00014079697,0.00014116836,0.000062278516,0.000009146555,0.00006087203,0.00044002943,0.000004666658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010690248,0.0003626458,0.037845813,0.00012715958,0.00011362804,0.0001575161,0.00025581243,0.005704405,0.95076275,0.0000012070891,0.0025430357,0.0010570227],"study_design_scores_gemma":[0.0044616284,0.0031459613,0.032941237,0.00033889493,0.00013795776,0.00014182164,0.00079813664,0.00015295802,0.95517904,0.000009166196,0.0023780554,0.0003151745],"about_ca_topic_score_codex":0.0000040004093,"about_ca_topic_score_gemma":1.8601975e-7,"teacher_disagreement_score":0.0055514467,"about_ca_system_score_codex":0.000022577293,"about_ca_system_score_gemma":0.00011564733,"threshold_uncertainty_score":0.72486126},"labels":[],"label_agreement":null},{"id":"W2981212714","doi":"10.1016/j.ejmech.2019.111783","title":"Discovery of covalent prolyl oligopeptidase boronic ester inhibitors","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Oligopeptidase; Covalent bond; Boronic acid; Enzyme inhibitor; Combinatorial chemistry; Stereochemistry; Biochemistry; Enzyme; Pharmacology; Organic chemistry","score_opus":0.007619377058113921,"score_gpt":0.23237701173456965,"score_spread":0.22475763467645574,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2981212714","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9772575,0.0005167741,0.00012207254,0.0009156863,0.00008145844,0.00008119084,0.0000066643847,0.000010927543,0.021007752],"genre_scores_gemma":[0.9943193,0.000069870446,0.00015331853,0.00041266534,0.0008056323,3.672173e-7,0.00001233181,0.000031093772,0.0041953875],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978476,0.00009515215,0.0009197003,0.00017886281,0.0007460161,0.00021266394],"domain_scores_gemma":[0.9984354,0.000043900825,0.0006994334,0.0003015803,0.0002696924,0.00025003418],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009365456,0.00018847459,0.00053943845,0.00010294343,0.000021814389,0.000016260561,0.00017367436,0.000040652034,0.0007402922],"category_scores_gemma":[0.00015770935,0.0001367221,0.00038381788,0.00018140153,0.00013962825,0.000166666,0.000053066204,0.00051156303,0.000066862274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00055297517,0.00032341835,0.008472101,0.00080775394,0.00023587806,0.0012794973,0.00024040625,0.00001661437,0.9823144,0.0000046826904,0.004099149,0.0016530916],"study_design_scores_gemma":[0.0099253,0.0016393265,0.020198366,0.012519303,0.0006927731,0.004236282,0.0015051566,0.00006356297,0.94031227,0.000012075698,0.008521491,0.00037409808],"about_ca_topic_score_codex":0.0000018064837,"about_ca_topic_score_gemma":1.2596108e-7,"teacher_disagreement_score":0.042002168,"about_ca_system_score_codex":0.00008252242,"about_ca_system_score_gemma":0.00020831022,"threshold_uncertainty_score":0.81056803},"labels":[],"label_agreement":null},{"id":"W2982513204","doi":"10.1016/j.ejmech.2019.111811","title":"Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Chemistry; Carbonic anhydrase; Context (archaeology); Combinatorial chemistry; Selectivity; Sulfonamide; Thiazolidine; Stereochemistry; Enzyme; Biochemistry","score_opus":0.009222214127119122,"score_gpt":0.24038856866090275,"score_spread":0.23116635453378362,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2982513204","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97003484,0.0005598333,0.00029546279,0.00034134867,0.0003159147,0.000084110965,0.000006415631,0.000008694848,0.028353382],"genre_scores_gemma":[0.9971448,0.00012303026,0.00013399067,0.00061426335,0.0009817096,7.331267e-7,0.000025381205,0.000027078437,0.00094899244],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988634,0.000047573925,0.00037774444,0.00024286307,0.0002781641,0.00019026258],"domain_scores_gemma":[0.99908644,0.000012529941,0.00022877427,0.0001919488,0.00017094807,0.00030937683],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005363244,0.00017111386,0.00020335373,0.00004888306,0.000040735693,0.00004464561,0.00022237844,0.00006095963,0.0001806074],"category_scores_gemma":[0.00019484888,0.00014549863,0.000084441526,0.00010915592,0.00005973568,0.000018381132,0.00009771024,0.00022137853,0.00001979465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021451067,0.00004428119,0.00058746035,0.000044136177,0.000042965174,0.000054784134,0.00004853913,0.000051574065,0.9919343,0.0000017772371,0.006181755,0.0007938879],"study_design_scores_gemma":[0.0015400699,0.0005184249,0.0014253656,0.00022556067,0.00004127235,0.0006116465,0.00012946523,0.000005802102,0.9472108,0.000001882599,0.048100866,0.00018882906],"about_ca_topic_score_codex":0.0000028076013,"about_ca_topic_score_gemma":8.090694e-7,"teacher_disagreement_score":0.04472351,"about_ca_system_score_codex":0.000023746046,"about_ca_system_score_gemma":0.00010579405,"threshold_uncertainty_score":0.59332615},"labels":[],"label_agreement":null},{"id":"W2985537913","doi":"10.1016/j.ejmech.2019.111866","title":"Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital","funders":"Chinese Academy of Medical Sciences; National Natural Science Foundation of China","keywords":"Chemistry; Pyrimidine; Acetamide; Ligand (biochemistry); Stereochemistry; In vivo; IC50; Protease; In vitro; Enzyme inhibitor; Cytotoxicity; HIV-1 protease; Enzyme; Nucleic acid; Biological activity; Human immunodeficiency virus (HIV); Structure–activity relationship; Potency; Protease inhibitor (pharmacology); Biochemistry; Virology; Biology; Receptor; Organic chemistry","score_opus":0.018861210007039508,"score_gpt":0.26887755298939164,"score_spread":0.25001634298235215,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2985537913","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9917637,0.0003580956,0.00017863716,0.0026303495,0.00005884628,0.0004909799,0.000013880285,0.000012104384,0.00449339],"genre_scores_gemma":[0.99698544,0.00006280709,0.0012890062,0.00012312965,0.00026775236,0.0000037698037,0.00002227284,0.000027011265,0.0012187868],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99776137,0.0001124303,0.00056360505,0.0003118312,0.0010234015,0.00022738586],"domain_scores_gemma":[0.9983003,0.000081168,0.0005099367,0.0002301368,0.00046211111,0.0004163127],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018653377,0.00026408542,0.00051552005,0.00009343254,0.00004924865,0.000011442765,0.00012498337,0.000049867966,0.000109462955],"category_scores_gemma":[0.0005244946,0.00016776883,0.00008163606,0.00016860728,0.00010526715,0.00008445286,0.00007144624,0.00032973758,0.000021699983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.009154325,0.0010596816,0.012310124,0.00037981034,0.0003182718,0.0010496653,0.0007761367,0.00006448895,0.95980346,8.3481484e-7,0.001116631,0.013966568],"study_design_scores_gemma":[0.0083969105,0.00399857,0.07530306,0.0046643666,0.0006507168,0.0010803669,0.0008484785,0.00020368595,0.9035865,0.0000028253155,0.0009673445,0.00029719336],"about_ca_topic_score_codex":0.0000013094356,"about_ca_topic_score_gemma":8.349383e-8,"teacher_disagreement_score":0.06299294,"about_ca_system_score_codex":0.00015207146,"about_ca_system_score_gemma":0.00041347233,"threshold_uncertainty_score":0.6841414},"labels":[],"label_agreement":null},{"id":"W2990226592","doi":"10.1016/j.ejmech.2019.111900","title":"Rational design and Structure−Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Jewish General Hospital","funders":"National Natural Science Foundation of China","keywords":"Chemistry; Coumarin; Reverse transcriptase; Rational design; Potency; Protease; IC50; Docking (animal); Enzyme; Human immunodeficiency virus (HIV); HIV-1 protease; Stereochemistry; Structure–activity relationship; Pharmacology; In vitro; Enzyme inhibitor; Combinatorial chemistry; Biochemistry; Virology; RNA; Organic chemistry; Nanotechnology","score_opus":0.016189080099612688,"score_gpt":0.2397227649883351,"score_spread":0.22353368488872244,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2990226592","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9950211,0.00012499138,0.0011722187,0.0017336464,0.00004183759,0.00042529646,0.000016348191,0.000006561921,0.0014579961],"genre_scores_gemma":[0.9967322,0.000020412579,0.0017586278,0.00008714942,0.00011958268,0.0000023740156,0.0000152043285,0.000017877454,0.0012465814],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986526,0.0002892518,0.00033673018,0.00018927072,0.00041306252,0.00011913226],"domain_scores_gemma":[0.9989093,0.00033749756,0.00030671144,0.000120253695,0.00011681961,0.00020941015],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00071141013,0.00018398397,0.00033950832,0.00006924341,0.000053646887,0.000008888493,0.000052584895,0.000037263842,0.00014890918],"category_scores_gemma":[0.00036932554,0.0001335375,0.000054786353,0.00007136711,0.00013154808,0.00007671853,0.000012317388,0.0004098396,0.0000074548616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.021562932,0.0010528149,0.24871133,0.0013370952,0.0009314038,0.0020580504,0.005166103,0.0003075196,0.70081735,0.000118316435,0.0053409254,0.0125961825],"study_design_scores_gemma":[0.017757833,0.0029883925,0.47324106,0.0030922312,0.0005597158,0.0010018994,0.00056084024,0.00023061114,0.4987239,0.000109569264,0.0014016755,0.0003322753],"about_ca_topic_score_codex":3.8733774e-7,"about_ca_topic_score_gemma":4.4800792e-8,"teacher_disagreement_score":0.22452973,"about_ca_system_score_codex":0.00006633308,"about_ca_system_score_gemma":0.00014196389,"threshold_uncertainty_score":0.5445501},"labels":[],"label_agreement":null},{"id":"W2998063956","doi":"10.1016/j.ejmech.2019.111990","title":"Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Prodrug; Substituent; Lead compound; Stereochemistry; In vivo; Pancreatic cancer; Cancer; In vitro; Biochemistry; Internal medicine","score_opus":0.02596049564491815,"score_gpt":0.27738411826427584,"score_spread":0.2514236226193577,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2998063956","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9938869,0.0005297281,0.00015217767,0.0014595393,0.00012736183,0.00028695056,0.000029319297,0.000007981576,0.0035200408],"genre_scores_gemma":[0.99912363,0.000038836257,0.00017944192,0.00014122225,0.00020387313,0.0000013099353,0.0000019885772,0.000023607648,0.00028609898],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982542,0.00011938856,0.00051485014,0.0002562679,0.00062225404,0.00023307919],"domain_scores_gemma":[0.9984848,0.000108736924,0.00037580932,0.00043431742,0.00029794007,0.00029840547],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00084169,0.00021510695,0.0005716208,0.000038692626,0.000043161064,0.000008633212,0.00027242283,0.000048133108,0.00025772877],"category_scores_gemma":[0.00024871482,0.00012390777,0.00022036472,0.00018298106,0.00018033246,0.000057010002,0.00005320878,0.0005543992,0.000006840589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013232065,0.00027772776,0.010238853,0.00032682056,0.00012133247,0.000035341567,0.00057185866,0.0000034675697,0.9845032,0.000004522064,0.00006758565,0.0025260537],"study_design_scores_gemma":[0.0012718762,0.00027823867,0.23778294,0.00035395092,0.00017873834,0.00013721093,0.00022923143,0.000021150458,0.7595269,0.0000079312085,0.0001235476,0.00008824837],"about_ca_topic_score_codex":0.0000033051583,"about_ca_topic_score_gemma":5.9846934e-7,"teacher_disagreement_score":0.22754408,"about_ca_system_score_codex":0.000089026085,"about_ca_system_score_gemma":0.00018984875,"threshold_uncertainty_score":0.50528127},"labels":[],"label_agreement":null},{"id":"W2998629608","doi":"10.1016/j.ejmech.2019.112030","title":"Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Institut national de la recherche scientifique; National Institutes of Health; Armand-Frappier Foundation","keywords":"Aromatase; Anastrozole; Chemistry; Ruthenium; In vivo; Estrogen receptor; Cancer research; Cancer cell; Letrozole; Cytotoxicity; Breast cancer; In vitro; Cancer; Pharmacology; Biochemistry; Internal medicine; Biology; Medicine","score_opus":0.07569791876454983,"score_gpt":0.278322782206363,"score_spread":0.20262486344181313,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2998629608","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99148494,0.00046005688,0.000016163047,0.004276174,0.000020236637,0.000083748135,0.000012717373,0.0000026201747,0.0036433483],"genre_scores_gemma":[0.9982443,0.00023213815,0.00094252295,0.00043224866,0.000118159835,0.0000014747696,7.3827437e-7,0.000012084687,0.000016348647],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984917,0.00020054764,0.0007061809,0.00014333831,0.0003326581,0.00012555248],"domain_scores_gemma":[0.99902695,0.00021580272,0.00040004283,0.00009806078,0.00008952127,0.00016962009],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011248247,0.00014433858,0.000523515,0.000030534604,0.00004861071,0.000007352076,0.00016595889,0.000023848268,0.00042556197],"category_scores_gemma":[0.00017527012,0.00007616894,0.000059844424,0.00008060823,0.0002297696,0.000021286498,0.00010742905,0.0002922346,4.5547824e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00063053484,0.0001220071,0.007379914,0.0003721842,0.000112930036,0.000051955554,0.0012784032,0.000002510772,0.9833517,0.0000065541644,0.00029908502,0.006392196],"study_design_scores_gemma":[0.0016799584,0.0007299384,0.3905491,0.0026824253,0.00016712464,0.00038904737,0.0029783307,0.00015813886,0.5977533,0.0000052777505,0.0027296725,0.00017767223],"about_ca_topic_score_codex":0.0000031249222,"about_ca_topic_score_gemma":2.8988023e-7,"teacher_disagreement_score":0.38559842,"about_ca_system_score_codex":0.000025041587,"about_ca_system_score_gemma":0.00010400654,"threshold_uncertainty_score":0.4659605},"labels":[],"label_agreement":null},{"id":"W2998800439","doi":"10.1016/j.ejmech.2020.112040","title":"Therapeutic potentials of curcumin in the treatment of glioblstoma","year":2020,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Curcumin; Glioblastoma; Therapeutic effect; Pharmacology; Chemotherapy; Apoptosis; Cancer research; Chemistry; Malignancy; Radiation therapy; Medicine; Internal medicine","score_opus":0.03555820212570054,"score_gpt":0.3248097767147469,"score_spread":0.2892515745890464,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2998800439","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0013982895,0.99681574,0.00028426838,0.00023314115,0.000065614266,0.00020387297,0.000042733154,0.0000016466074,0.0009546656],"genre_scores_gemma":[0.018675657,0.9800549,0.000097104814,0.000043860393,0.00095031754,0.0000058335563,0.0000658284,0.000037679805,0.00006880588],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99753165,0.00037405587,0.0012951092,0.00022150463,0.00041801724,0.00015963559],"domain_scores_gemma":[0.99786836,0.000084855405,0.0013907215,0.0004226719,0.00010899989,0.00012441642],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00073771056,0.0002842243,0.0010558692,0.000054892986,0.000017850258,0.0000057869515,0.0008269911,0.00011726356,0.000050093073],"category_scores_gemma":[0.00011978163,0.00016674737,0.0005793572,0.00026736612,0.00028411366,0.0000017596637,0.000048996673,0.0002738163,0.0000038894277],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000071494476,0.00050449074,0.0000059692243,0.0031109941,0.0004218129,0.00026280244,0.00022985417,4.3538387e-7,0.046215728,0.0000036829795,0.00090507977,0.94826764],"study_design_scores_gemma":[0.0006458699,0.000971262,0.00001583011,0.0018613911,0.00069764775,0.0007301185,0.00013811361,3.773057e-7,0.010883056,0.000006419888,0.9839267,0.00012320589],"about_ca_topic_score_codex":0.0000016963301,"about_ca_topic_score_gemma":2.2194793e-7,"teacher_disagreement_score":0.9830216,"about_ca_system_score_codex":0.00003418627,"about_ca_system_score_gemma":0.0002962688,"threshold_uncertainty_score":0.67997605},"labels":[],"label_agreement":null},{"id":"W3006725389","doi":"10.1016/j.ejmech.2020.112185","title":"Comparative analysis of the dual EGFR-DNA targeting and growth inhibitory properties of 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline-based type II combi-molecules","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Group for Research in Decision Analysis; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; Institut de recherche, Centre universitaire de santé McGill","keywords":"Chemistry; DNA; Molecule; Inhibitory postsynaptic potential; Stereochemistry; Dual (grammatical number); In vitro; Combinatorial chemistry; Biochemistry; Organic chemistry","score_opus":0.02444608287194988,"score_gpt":0.2236019890308777,"score_spread":0.1991559061589278,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3006725389","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9934775,0.0024196678,0.000039299237,0.0010131745,0.000020978134,0.000040687253,0.00002035672,0.000008553822,0.0029597601],"genre_scores_gemma":[0.99932134,0.00008341525,0.00019182063,0.000099678844,0.000245073,8.1991425e-7,0.000006494775,0.00001717046,0.00003421206],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99829054,0.000103757804,0.00082661567,0.0002090226,0.00040972064,0.0001603586],"domain_scores_gemma":[0.9981845,0.000111676236,0.0009762874,0.00018197045,0.00036916544,0.00017640162],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004720111,0.00020560251,0.00063400815,0.00004834075,0.00012342737,0.000014175431,0.00029394226,0.00004618724,0.00008790956],"category_scores_gemma":[0.0003592129,0.0001419199,0.0001656459,0.00033014434,0.00055750954,0.000048450358,0.00015279626,0.00036651836,4.135433e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019724405,0.0001120444,0.003318253,0.00043477167,0.00038118626,0.00001759262,0.0014867136,0.000061918225,0.9934645,0.000020368554,0.00025730953,0.0002480849],"study_design_scores_gemma":[0.0008265936,0.00012405596,0.0050745765,0.00039379852,0.0009308794,0.000023749846,0.0018232197,0.0006564832,0.989649,0.000004223822,0.00034770434,0.00014569456],"about_ca_topic_score_codex":0.0000046996265,"about_ca_topic_score_gemma":3.2908426e-7,"teacher_disagreement_score":0.005843793,"about_ca_system_score_codex":0.000019373983,"about_ca_system_score_gemma":0.00011344893,"threshold_uncertainty_score":0.57873255},"labels":[],"label_agreement":null},{"id":"W3009014659","doi":"10.1016/j.ejmech.2020.112195","title":"Structure-thermodynamics-relationships of hepatitis C viral NS3 protease inhibitors","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Boehringer Ingelheim (Canada); Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Welch Foundation","keywords":"Chemistry; Substituent; Enthalpy; Steric effects; Quinoline; Stereochemistry; Pyridine; Thermodynamics; Medicinal chemistry; Organic chemistry","score_opus":0.030413876193548458,"score_gpt":0.2673142529570368,"score_spread":0.23690037676348835,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3009014659","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98314774,0.00041024218,0.0006189944,0.0028863396,0.000080859834,0.00017117575,0.00003188497,0.000017750366,0.012635021],"genre_scores_gemma":[0.9971136,0.00008578013,0.0010233193,0.00025570136,0.0013483821,5.7745973e-7,0.000015949327,0.000048511825,0.000108209075],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99727273,0.00032493248,0.0009277087,0.0001802964,0.0010589359,0.0002354027],"domain_scores_gemma":[0.998023,0.00008432942,0.0005429492,0.00021025399,0.00044147664,0.0006980351],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00088684383,0.00018201677,0.00046159595,0.000076009725,0.000057886562,0.000012448736,0.0002788361,0.00006247062,0.00072044175],"category_scores_gemma":[0.002382553,0.00014827226,0.0001703127,0.00025591525,0.00023639321,0.00009553893,0.00007135435,0.0014013125,0.000018649416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0009995993,0.00013435894,0.11095189,0.0010471849,0.00023845535,0.004080582,0.0015172763,0.000051227522,0.8575078,0.000012929565,0.0045304494,0.018928243],"study_design_scores_gemma":[0.01817697,0.0062474087,0.18642673,0.004965098,0.0009407457,0.003472245,0.0015716834,0.004700226,0.74897724,0.00023197757,0.023310788,0.0009788717],"about_ca_topic_score_codex":0.000010344384,"about_ca_topic_score_gemma":8.097018e-7,"teacher_disagreement_score":0.10853055,"about_ca_system_score_codex":0.000094073206,"about_ca_system_score_gemma":0.0003682152,"threshold_uncertainty_score":0.7888332},"labels":[],"label_agreement":null},{"id":"W3013348624","doi":"10.1016/j.ejmech.2020.112262","title":"Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases","year":2020,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"Engineering and Physical Sciences Research Council; Queen's University; Queen's University Belfast","keywords":"Antibiotics; Peptidoglycan; Penicillin binding proteins; Bacterial cell structure; Penicillin; Cell wall; Chemistry; Microbiology; Bacteria; Enzyme; Antibiotic resistance; Lipid II; Biochemistry; Biology; Genetics","score_opus":0.029749226837912826,"score_gpt":0.2923576761902254,"score_spread":0.2626084493523126,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3013348624","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0006042313,0.9896191,0.0012117323,0.00089824706,0.00027800223,0.0003187966,0.000089193265,0.000033407337,0.0069473353],"genre_scores_gemma":[0.018647656,0.967116,0.0003824038,0.00033838436,0.012571714,0.0000020218788,0.00028439832,0.00014017659,0.0005172366],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99686915,0.0003011105,0.0015756246,0.00032840524,0.0005900138,0.00033571845],"domain_scores_gemma":[0.99735516,0.00030686212,0.001559699,0.00025752097,0.00019688187,0.0003238827],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0011905816,0.00051101623,0.0019217139,0.00008415615,0.00014414736,0.00017781708,0.0004621857,0.00010398585,0.00028269694],"category_scores_gemma":[0.0002747146,0.00029141136,0.0016773909,0.00024196426,0.00019940539,0.00017077808,0.00004346282,0.0011841577,0.000015377465],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012134131,0.00072818797,0.000008415915,0.19208723,0.003474665,0.011342251,0.0013927331,0.000013797764,0.06276004,0.000019497347,0.071178116,0.6557816],"study_design_scores_gemma":[0.0015008796,0.0003256899,0.0000019749666,0.05686979,0.004611956,0.0018775698,0.0008413127,0.0000072547373,0.001203121,0.0000032287687,0.9324585,0.00029871],"about_ca_topic_score_codex":0.0000014207134,"about_ca_topic_score_gemma":1.5463384e-7,"teacher_disagreement_score":0.8612804,"about_ca_system_score_codex":0.00009869187,"about_ca_system_score_gemma":0.00084966165,"threshold_uncertainty_score":0.9999538},"labels":[],"label_agreement":null},{"id":"W3014843513","doi":"10.1016/j.ejmech.2020.112270","title":"Design and discovery of boronic acid drugs","year":2020,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Organoboron and organosilicon chemistry","field":"Chemistry","cited_by":199,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Boronic acid; Drug discovery; Chemistry; Scope (computer science); Drug; Pharmacology; Combinatorial chemistry; Biochemistry; Medicine; Computer science","score_opus":0.024098456520842807,"score_gpt":0.26353141153709186,"score_spread":0.23943295501624906,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3014843513","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00027266872,0.9930679,0.00022893096,0.000097404525,0.00012460466,0.0000628485,0.000038854978,0.000027927099,0.00607883],"genre_scores_gemma":[0.0031767793,0.9939485,0.00041125575,0.000038240963,0.0017426712,0.000001242603,0.000026387717,0.0001779252,0.00047696635],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99616325,0.00019943053,0.002015456,0.0004765437,0.0007699697,0.0003753249],"domain_scores_gemma":[0.99591863,0.00030754783,0.0026033118,0.0005154792,0.00014035925,0.00051469356],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00094071386,0.00073574635,0.0025751595,0.000054092892,0.00005398686,0.000060726255,0.0011351092,0.0002630317,0.0008809632],"category_scores_gemma":[0.00044358685,0.00058461743,0.0006305601,0.00019537045,0.00037720092,0.00014665218,0.00028795283,0.0019060454,0.000016387006],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013707428,0.00013419293,0.0000029675336,0.079748504,0.00087721384,0.002394526,0.00040306096,5.58172e-7,0.1376086,0.0000019953857,0.0030201576,0.7756711],"study_design_scores_gemma":[0.0010924643,0.00009722102,3.5451305e-7,0.02412483,0.0018441007,0.0033128909,0.00029311245,0.0000018590473,0.33358508,0.0000042165016,0.6351219,0.000521968],"about_ca_topic_score_codex":4.4350188e-7,"about_ca_topic_score_gemma":1.0133284e-8,"teacher_disagreement_score":0.77514917,"about_ca_system_score_codex":0.00017797049,"about_ca_system_score_gemma":0.00094136066,"threshold_uncertainty_score":0.99966055},"labels":[],"label_agreement":null},{"id":"W3034152397","doi":"10.1016/j.ejmech.2020.112411","title":"PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society; Ontario Research Foundation","keywords":"Chemistry; HDAC6; Druggability; Cancer research; Pharmacology; Histone deacetylase; Biochemistry; Biology; Histone","score_opus":0.02043275046612374,"score_gpt":0.28005990550090676,"score_spread":0.259627155034783,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3034152397","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9837487,0.0019536102,0.00069556694,0.0014196807,0.00009413275,0.00012039595,0.000011525528,0.00001035846,0.011946052],"genre_scores_gemma":[0.9957805,0.00017272381,0.00019724626,0.0008102449,0.002283272,0.0000023014347,0.000019415598,0.00006387047,0.0006704068],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99759984,0.0002282831,0.00071191636,0.0003902867,0.0006180102,0.0004516783],"domain_scores_gemma":[0.998619,0.0000320745,0.00035562957,0.00023570233,0.00029128508,0.0004663104],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009691485,0.00027887415,0.00037430433,0.000050986542,0.00006385805,0.000032319076,0.00056415354,0.000114507,0.000099952704],"category_scores_gemma":[0.0004716422,0.0002506553,0.00018677388,0.00030195218,0.00020754167,0.0000133059875,0.00014295075,0.0010324958,0.000040465748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010592408,0.00010266871,0.00020761596,0.000059143076,0.00015531378,0.0011455079,0.00030113367,0.00017317114,0.98686796,0.0000017381858,0.008162079,0.0017643959],"study_design_scores_gemma":[0.0036867082,0.0019719026,0.0007905101,0.0001885296,0.00006458208,0.0016947512,0.0005623831,0.000051442836,0.97001314,0.000008999325,0.02065311,0.00031391767],"about_ca_topic_score_codex":0.000005939211,"about_ca_topic_score_gemma":0.0000021309272,"teacher_disagreement_score":0.016854828,"about_ca_system_score_codex":0.00010673039,"about_ca_system_score_gemma":0.0006656483,"threshold_uncertainty_score":0.9999946},"labels":[],"label_agreement":null},{"id":"W3044799739","doi":"10.1016/j.ejmech.2020.112658","title":"Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Novartis Pharmaceuticals Canada; Alberta Cancer Foundation","keywords":"ERCC1; Chemistry; Nucleotide excision repair; Endonuclease; Cytotoxicity; Biochemistry; In vitro; DNA repair; DNA; Pharmacophore; DNA damage; Pharmacology; Stereochemistry; Biology","score_opus":0.02642263656974303,"score_gpt":0.235635395715013,"score_spread":0.20921275914526996,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3044799739","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9845021,0.0014056221,0.012646597,0.00042235455,0.0000637883,0.00010638661,0.000016117281,0.000014157072,0.00082290615],"genre_scores_gemma":[0.98080206,0.00006340051,0.018451225,0.0002219142,0.00039943957,0.0000021947703,0.000012607036,0.000031110336,0.000016030914],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99803054,0.00035848597,0.0007454211,0.00030339943,0.00034669298,0.0002154582],"domain_scores_gemma":[0.99871093,0.00012743617,0.00051972485,0.00022772711,0.00017053448,0.0002436567],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00206895,0.00020508985,0.00032658665,0.00003951886,0.00004016781,0.000008725486,0.00035520957,0.000097416254,0.000036979072],"category_scores_gemma":[0.0021851072,0.00017271283,0.00016251023,0.00012278049,0.00013284868,0.0000060537504,0.00014148241,0.00030737862,0.0000010656903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005688294,0.0001593448,0.00012966739,0.00013100043,0.000023639283,0.00012678027,0.0000978849,0.0003714661,0.9972973,1.3417069e-7,0.0007167856,0.00037716184],"study_design_scores_gemma":[0.0018158343,0.0005262681,0.000084608946,0.00012997173,0.00004844863,0.00005415413,0.00037841324,0.00082239765,0.995542,0.0000027575488,0.00043322888,0.00016194214],"about_ca_topic_score_codex":8.2313096e-7,"about_ca_topic_score_gemma":4.8113048e-8,"teacher_disagreement_score":0.005804627,"about_ca_system_score_codex":0.000022187469,"about_ca_system_score_gemma":0.00019125058,"threshold_uncertainty_score":0.7043025},"labels":[],"label_agreement":null},{"id":"W3068892982","doi":"10.1016/j.ejmech.2020.112721","title":"Selective targeting of the αC and DFG-out pocket in p38 MAPK","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Pfizer Canada; Merck Sharp and Dohme; AbbVie Deutschland; Innovative Medicines Initiative; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Merck KGaA; Boehringer Ingelheim; Wellcome Trust; Bayer","keywords":"Chemistry; Allosteric regulation; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Binding pocket; Drug discovery; Combinatorial chemistry; Binding site; Computational biology; Signal transduction; Biochemistry; Receptor; Biology","score_opus":0.01038204048651175,"score_gpt":0.2036884798109804,"score_spread":0.19330643932446864,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3068892982","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98950243,0.0018833786,0.00013763303,0.0006424154,0.00007905106,0.00003505161,0.0000041843036,0.0000015479592,0.007714323],"genre_scores_gemma":[0.99857104,0.0000958959,0.0001700492,0.00041322003,0.0006425196,1.9482081e-7,0.0000030342953,0.000013325326,0.000090734495],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9991076,0.00012607906,0.00034854782,0.00012864951,0.00016767601,0.000121463905],"domain_scores_gemma":[0.99940705,0.000013959908,0.00028452178,0.000094051895,0.00008374417,0.00011667954],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00049457676,0.00009970757,0.00016668274,0.000010179772,0.000024840732,0.000004909238,0.00023115546,0.000035116187,0.00002427267],"category_scores_gemma":[0.00047476694,0.000069337824,0.0000668634,0.00006129676,0.00008553213,0.0000028856657,0.0001035805,0.0002711151,9.4852174e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012507365,0.000016288583,0.0035334418,0.00007720068,0.000024756788,0.000064007116,0.0004581041,0.000006142241,0.99140614,0.0000011301557,0.0035782375,0.00070947275],"study_design_scores_gemma":[0.0009669767,0.00032141013,0.006263909,0.00012418143,0.000021788988,0.00015100765,0.00055616203,0.000010578199,0.98179334,0.000008321701,0.009696457,0.00008588758],"about_ca_topic_score_codex":7.89738e-7,"about_ca_topic_score_gemma":3.1896172e-7,"teacher_disagreement_score":0.009612825,"about_ca_system_score_codex":0.0000070963533,"about_ca_system_score_gemma":0.000076092096,"threshold_uncertainty_score":0.28275144},"labels":[],"label_agreement":null},{"id":"W3081119757","doi":"10.1016/j.ejmech.2020.112770","title":"Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Innovative Medicines Initiative; Ontario Ministry of Economic Development and Innovation; Genome Canada; AbbVie; Pfizer","keywords":"Casein kinase 2; Kinase; Chemistry; Moiety; Threonine; Drug discovery; Biochemistry; Lead compound; Casein kinase 1; Serine; Protein kinase A; In vitro; Stereochemistry; Phosphorylation; Cyclin-dependent kinase 2","score_opus":0.013572214279445922,"score_gpt":0.23539079535225252,"score_spread":0.2218185810728066,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3081119757","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9475033,0.0015756515,0.046454433,0.00369251,0.00010603914,0.00014188819,0.000017602393,0.0000052795644,0.00050326186],"genre_scores_gemma":[0.9975675,0.00006364878,0.00091263733,0.00020733883,0.0011728152,9.568392e-7,0.000018294711,0.000016893884,0.00003992012],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987025,0.00012132881,0.000660503,0.00014138027,0.00027331052,0.00010097505],"domain_scores_gemma":[0.99852353,0.000013036149,0.0006882605,0.00014928257,0.0005007215,0.0001251622],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00077261234,0.00010749641,0.00017473719,0.000028391012,0.000036995032,0.000008151666,0.000233631,0.000035837747,0.000015937892],"category_scores_gemma":[0.00061541353,0.00008095496,0.00009715498,0.00018685228,0.00008022304,0.000006673014,0.000052300373,0.00012727111,0.0000015466445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003452486,0.000032509157,0.000036685044,0.00008810926,0.00004001715,0.000021668708,0.00028457784,0.013391442,0.9825775,0.0000029362463,0.001531497,0.0016477968],"study_design_scores_gemma":[0.00055414304,0.0003537669,0.0001583007,0.000092290415,0.00004892293,0.00006184595,0.00040870908,0.00060113525,0.99454194,0.0000018646326,0.003102021,0.000075065036],"about_ca_topic_score_codex":0.0000010919522,"about_ca_topic_score_gemma":1.8474442e-7,"teacher_disagreement_score":0.050064158,"about_ca_system_score_codex":0.000012714584,"about_ca_system_score_gemma":0.00009893323,"threshold_uncertainty_score":0.33012474},"labels":[],"label_agreement":null},{"id":"W3081416380","doi":"10.1016/j.ejmech.2020.112759","title":"Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec-Société et Culture; Crohn's and Colitis Canada; Higher Education Commission, Pakistan","keywords":"Chemistry; Oxazole; Cyclic nucleotide phosphodiesterase; Phosphodiesterase; Biochemistry; Enzyme; Stereochemistry","score_opus":0.017820334160683834,"score_gpt":0.25275701269847034,"score_spread":0.2349366785377865,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3081416380","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98599595,0.012329737,0.0007422195,0.00061131426,0.000034399425,0.000040522504,0.000009763143,0.000004297401,0.00023179813],"genre_scores_gemma":[0.99773026,0.00097315543,0.00047928,0.00025251208,0.0005254162,6.339849e-7,0.000010871725,0.000018565825,0.000009297201],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989802,0.000039694234,0.0004610229,0.00019556047,0.00019271219,0.0001307947],"domain_scores_gemma":[0.99910814,0.00008534978,0.00034934195,0.00009432845,0.00013922919,0.00022360806],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005189966,0.00015429914,0.00025292003,0.000017452,0.0000629547,0.000013187814,0.00014733474,0.000046666904,0.00005932876],"category_scores_gemma":[0.000872538,0.00012304136,0.000063680054,0.00007000598,0.00024284609,0.000008375657,0.000114079456,0.00017500462,0.0000011896358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024281333,0.000028680632,0.0033668838,0.00008157788,0.00008494782,0.000093888106,0.00022394441,0.00006854191,0.9928124,0.000002030588,0.0013215225,0.0016727791],"study_design_scores_gemma":[0.0007012599,0.0005244917,0.0018124608,0.00018493559,0.000085056614,0.00016724254,0.00091269973,0.00011970626,0.99377275,0.000010021471,0.0015665618,0.00014279361],"about_ca_topic_score_codex":0.0000023273753,"about_ca_topic_score_gemma":3.805193e-8,"teacher_disagreement_score":0.011734319,"about_ca_system_score_codex":0.000005335552,"about_ca_system_score_gemma":0.000053397485,"threshold_uncertainty_score":0.5017481},"labels":[],"label_agreement":null},{"id":"W3088045753","doi":"10.1016/j.ejmech.2020.112863","title":"Amphiphilic desmuramyl peptides for the rational design of new vaccine adjuvants: Synthesis, in vitro modulation of inflammatory response and molecular docking studies","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Energy; NOSM University; Lakehead University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Muramyl dipeptide; Chemistry; NOD2; Rational design; Docking (animal); Stereochemistry; Dipeptide; Biochemistry; In vitro; Receptor; Innate immune system; Amino acid; Biology","score_opus":0.033153266914804184,"score_gpt":0.2597577051853577,"score_spread":0.2266044382705535,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3088045753","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9756982,0.015452739,0.0064482973,0.002217045,0.00005159135,0.000118442826,0.0000020459534,0.0000035633964,0.000008109671],"genre_scores_gemma":[0.99904996,0.00043098506,0.0003429822,0.00006452997,0.0000836246,0.0000016067575,0.0000028083607,0.000010789682,0.000012731789],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984842,0.0005508183,0.0006945228,0.0000899825,0.000079202655,0.00010126793],"domain_scores_gemma":[0.9977733,0.0013223985,0.00059766264,0.00008943696,0.00019365456,0.000023543858],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021778313,0.00010606912,0.0003025007,0.00005523215,0.000044985925,0.0000035626178,0.00015875004,0.000039484537,0.000016919948],"category_scores_gemma":[0.0035959654,0.00007497022,0.00006522234,0.000077288394,0.00010854141,0.00007928909,0.000034235996,0.00018956652,7.6485884e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0123231085,0.000013283362,0.00013479953,0.00011840177,0.00020873091,0.000020570547,0.0015392742,0.0014736537,0.97777164,0.0000038013359,0.00026533558,0.0061273947],"study_design_scores_gemma":[0.0019383989,0.0002308016,0.007269603,0.00037001172,0.00008864464,0.000121306664,0.0012333186,0.00024167188,0.9880304,0.000032086737,0.00037928825,0.00006451069],"about_ca_topic_score_codex":7.956998e-7,"about_ca_topic_score_gemma":4.9772495e-8,"teacher_disagreement_score":0.023351775,"about_ca_system_score_codex":0.000021269147,"about_ca_system_score_gemma":0.00012851483,"threshold_uncertainty_score":0.43049663},"labels":[],"label_agreement":null},{"id":"W3092223474","doi":"10.1016/j.ejmech.2020.112902","title":"SP1-independent inhibition of FOXM1 by modified thiazolidinediones","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta","keywords":"Chemistry; Thiazolidinedione; Troglitazone; Reporter gene; FOXM1; Electrophoretic mobility shift assay; In vitro; Ligand binding assay; Pioglitazone; Transcription factor; Biochemistry; Pharmacology; Gene expression; Peroxisome proliferator-activated receptor; Receptor; Gene; Biology","score_opus":0.0154233924911126,"score_gpt":0.21629265439064865,"score_spread":0.20086926189953605,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3092223474","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9863446,0.0009266749,0.008481792,0.0012176661,0.00010251575,0.00004197812,0.000014653295,0.0000060501347,0.0028640954],"genre_scores_gemma":[0.99862283,0.00011769746,0.00015360386,0.00022598123,0.0006937115,2.429058e-7,0.000060591858,0.000020569054,0.00010475457],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99878955,0.0000866573,0.00049624895,0.0001470905,0.00037101854,0.00010943145],"domain_scores_gemma":[0.9991155,0.0000064576966,0.0003973542,0.00011510601,0.00018529997,0.00018023318],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003733178,0.00012377997,0.00017907079,0.000016912301,0.000023686183,0.0000075922667,0.00016770409,0.000052695766,0.000076107826],"category_scores_gemma":[0.00013545921,0.000110167945,0.00012207868,0.00006205665,0.000077824196,0.000008281795,0.000029455703,0.00018716844,0.000003912252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003068639,0.000040080125,0.00015541089,0.00008037371,0.00004308176,0.000029783809,0.000111182875,0.00012174613,0.99022484,0.0000032928842,0.008063397,0.0008199346],"study_design_scores_gemma":[0.0014918625,0.00053728285,0.00081341725,0.00007501022,0.000041996464,0.00010408287,0.00016868407,0.00003828681,0.9892613,0.000007715615,0.0073559154,0.0001044111],"about_ca_topic_score_codex":6.059263e-7,"about_ca_topic_score_gemma":6.328999e-8,"teacher_disagreement_score":0.012278274,"about_ca_system_score_codex":0.000011466118,"about_ca_system_score_gemma":0.00004628182,"threshold_uncertainty_score":0.44925183},"labels":[],"label_agreement":null},{"id":"W3092606230","doi":"10.1016/j.ejmech.2020.112909","title":"Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Faculté de Médecine, Université Laval; Mitacs","keywords":"Chemistry; Hydroxysteroid dehydrogenase; Steroid; Potency; Stereochemistry; IC50; Selectivity; Estrone; Dehydrogenase; Enzyme; Biochemistry; In vitro; Hormone","score_opus":0.008723496587154886,"score_gpt":0.2121507951684654,"score_spread":0.20342729858131053,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3092606230","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9904027,0.007055725,0.00016728145,0.00019976513,0.00006892573,0.00006456919,0.0000065391396,0.000006605887,0.0020278925],"genre_scores_gemma":[0.99855924,0.00049090607,0.00015871471,0.00007234026,0.00064132543,5.688281e-7,0.00000541449,0.000030379568,0.000041126015],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984423,0.0002949946,0.0005284703,0.00025436547,0.0002835987,0.00019628431],"domain_scores_gemma":[0.9988002,0.000041724394,0.00042456848,0.0001822196,0.00021943492,0.00033185168],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007246017,0.00020349554,0.00038063314,0.00002285527,0.000041014253,0.00001142767,0.00023277916,0.00008944487,0.000058083435],"category_scores_gemma":[0.00079053483,0.00016516032,0.00013523862,0.00013312536,0.0001688949,0.000009943128,0.000114774375,0.0003310106,0.0000044126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00061456556,0.00007523257,0.0002922584,0.00016780246,0.00017090747,0.0000864617,0.00016015112,0.0000086261625,0.9946076,2.3767436e-7,0.0003198518,0.0034962848],"study_design_scores_gemma":[0.000832804,0.00094963674,0.0002391094,0.00011187128,0.00014800263,0.0002812877,0.00012993337,0.0000187674,0.99619216,0.0000018732342,0.0009514461,0.00014313638],"about_ca_topic_score_codex":0.0000012555696,"about_ca_topic_score_gemma":1.423227e-7,"teacher_disagreement_score":0.008156529,"about_ca_system_score_codex":0.000009589,"about_ca_system_score_gemma":0.00011589187,"threshold_uncertainty_score":0.67350423},"labels":[],"label_agreement":null},{"id":"W3100239861","doi":"10.1016/j.ejmech.2020.113005","title":"Development and biological evaluation of[18F]FMN3PA &amp; [18F]FMN3PU for leucine-rich repeat kinase 2 (LRRK2) in vivo PET imaging","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Simon Fraser University; University of Alberta; University of British Columbia; TRIUMF","funders":"Canadian Cancer Society Research Institute","keywords":"Chemistry; In vivo; Leucine-rich repeat; LRRK2; Kinase; Biochemistry; Gene; Genetics","score_opus":0.07412122083218689,"score_gpt":0.30893490068439544,"score_spread":0.23481367985220855,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3100239861","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9932906,0.0027403748,0.0005017032,0.0010342179,0.000066709465,0.00020934259,0.000011151965,0.0000114241275,0.002134444],"genre_scores_gemma":[0.99287134,0.00011883693,0.0062330463,0.00032876548,0.00033817455,0.000005018326,0.0000260467,0.000024940118,0.00005381965],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99799985,0.00013846117,0.0007300146,0.00028244784,0.0006300583,0.00021916431],"domain_scores_gemma":[0.9986252,0.00006991612,0.00042193034,0.00013581353,0.00034122594,0.00040591884],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0019194216,0.00020828805,0.0004554376,0.00006760401,0.000047297915,0.000010772923,0.00012424632,0.000019680421,0.00022025425],"category_scores_gemma":[0.0009712096,0.00015474662,0.00009768023,0.0001339806,0.00006886825,0.00005638743,0.000053767646,0.00024384394,0.000003400437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0046718162,0.0010231009,0.049211394,0.0012795224,0.000541864,0.009085233,0.0030992443,0.00003957459,0.83738756,0.0000113053175,0.0037411118,0.08990828],"study_design_scores_gemma":[0.06604487,0.0024994703,0.11964182,0.0052627753,0.0029104336,0.009732687,0.006003114,0.002311931,0.65532434,0.00017833927,0.12897532,0.0011148795],"about_ca_topic_score_codex":9.81719e-7,"about_ca_topic_score_gemma":4.1760703e-7,"teacher_disagreement_score":0.18206319,"about_ca_system_score_codex":0.00012384598,"about_ca_system_score_gemma":0.00027150087,"threshold_uncertainty_score":0.6310384},"labels":[],"label_agreement":null},{"id":"W3109972097","doi":"10.1016/j.ejmech.2020.113062","title":"Undecaprenol kinase: Function, mechanism and substrate specificity of a potential antibiotic target","year":2020,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Trinity College","funders":"Medical Research Council; Engineering and Physical Sciences Research Council; Science Foundation Ireland","keywords":"Biochemistry; Kinase; Diacylglycerol kinase; Chemistry; Escherichia coli; Phosphatase; MAP3K7; Bacteria; Biology; Protein kinase A; Enzyme; Gene; Protein kinase C; MAP kinase kinase kinase; Genetics","score_opus":0.015268900523603135,"score_gpt":0.23451306448477535,"score_spread":0.21924416396117222,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3109972097","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.009650197,0.988041,0.0011076641,0.000074979835,0.00043335248,0.0001197281,0.00006147704,0.0000066066386,0.0005049892],"genre_scores_gemma":[0.056536455,0.9410039,0.00050657557,0.000022720753,0.0017109935,3.006682e-7,0.00007906445,0.000058726357,0.00008122169],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.99795306,0.00020554966,0.0010028565,0.00036736258,0.00024989233,0.00022127182],"domain_scores_gemma":[0.99807465,0.000010512506,0.0012427488,0.0002929069,0.00016194394,0.00021722673],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005471135,0.00037922594,0.0010787925,0.0000620411,0.000040001913,0.00002162877,0.00047978648,0.0003189692,0.00006232648],"category_scores_gemma":[0.000101729456,0.00030192133,0.00034405765,0.0001296498,0.00024210106,0.0000028133875,0.00021229287,0.0006107548,0.0000037173825],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00026093124,0.00011789918,0.0000029732014,0.007039363,0.00081281265,0.00088334724,0.000017454935,0.0000014484187,0.7508389,0.000028925204,0.0009309933,0.23906496],"study_design_scores_gemma":[0.0008329277,0.0015042778,0.00001535485,0.0029913343,0.0011300794,0.002561524,0.00007545174,0.0000017446997,0.108595766,0.00006634988,0.8818255,0.00039968576],"about_ca_topic_score_codex":5.5580375e-7,"about_ca_topic_score_gemma":1.2451977e-7,"teacher_disagreement_score":0.8808945,"about_ca_system_score_codex":0.00001590142,"about_ca_system_score_gemma":0.0002575833,"threshold_uncertainty_score":0.9999433},"labels":[],"label_agreement":null},{"id":"W3115632487","doi":"10.1016/j.ejmech.2020.113116","title":"Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ministero dell’Istruzione, dell’Università e della Ricerca; Ministero della Salute; Ministry of Health","keywords":"Chemistry; Allosteric regulation; Stereochemistry; Radioligand; Carboxamide; Moiety; Allosteric modulator; Structure–activity relationship; Cannabinoid receptor; Cannabinoid; Amide; Binding site; In vitro; Receptor; Agonist; Biochemistry","score_opus":0.042414649995316356,"score_gpt":0.2760284428614963,"score_spread":0.23361379286617995,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3115632487","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.95512706,0.00042109448,0.0027200955,0.0407111,0.0001941223,0.00033012393,0.000033307304,0.000010284084,0.00045282164],"genre_scores_gemma":[0.9978298,0.000035320292,0.00031029683,0.0002765349,0.0010791222,0.0000020456173,0.000011642688,0.000034005465,0.00042121042],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9979976,0.0003029722,0.0005801284,0.00018505991,0.00071396184,0.00022028878],"domain_scores_gemma":[0.9981644,0.00007116278,0.0006780378,0.00026925103,0.00056233525,0.00025482074],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011824183,0.00017442342,0.00034497437,0.000036497808,0.00022161027,0.000021761387,0.00037539058,0.000048902166,0.00015535465],"category_scores_gemma":[0.0024869968,0.000097309974,0.00022491165,0.00039318707,0.00028743033,0.00009419533,0.00007947017,0.00092794513,8.863532e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011086192,0.000050470724,0.0019447631,0.00039186937,0.000120226905,0.000031378502,0.0013857994,0.00025466873,0.9771082,0.000016544707,0.014111243,0.0034762393],"study_design_scores_gemma":[0.00668093,0.0012457758,0.32424593,0.0010069188,0.0005397459,0.0011422831,0.0023539905,0.0033106862,0.6021979,0.0000788275,0.056828808,0.00036821276],"about_ca_topic_score_codex":0.0000057034426,"about_ca_topic_score_gemma":9.659066e-7,"teacher_disagreement_score":0.3749103,"about_ca_system_score_codex":0.00011537701,"about_ca_system_score_gemma":0.0003865629,"threshold_uncertainty_score":0.40315112},"labels":[],"label_agreement":null},{"id":"W3116917620","doi":"10.1016/j.ejmech.2020.113137","title":"Targeting MYC: From understanding its biology to drug discovery","year":2020,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Small molecule; Drug discovery; Computational biology; Chemistry; Chemical biology; Oncogene; Structural biology; Identification (biology); G-quadruplex; Drug; Cancer research; Biochemistry; Biology; Pharmacology; Gene; DNA; Cell cycle","score_opus":0.04627653380443609,"score_gpt":0.29989375477864383,"score_spread":0.25361722097420775,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3116917620","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00020631611,0.9908533,0.0056459755,0.00030591126,0.0005582697,0.00013836152,0.00008118098,0.000008761603,0.002201926],"genre_scores_gemma":[0.0033465778,0.98863107,0.00042528342,0.0002886883,0.0063637467,0.0000019398349,0.0003540537,0.000088234716,0.0005004118],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9976317,0.00039819023,0.0010295741,0.00041203885,0.0002693836,0.00025910142],"domain_scores_gemma":[0.99827313,0.000052833402,0.000970067,0.00023985915,0.000089244786,0.00037486633],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00076685386,0.00039293012,0.00094188505,0.000057752215,0.000068328336,0.000052229687,0.00071212935,0.00013078292,0.0000888832],"category_scores_gemma":[0.0009290202,0.00030665135,0.00042181808,0.00014860781,0.00006958409,0.000009679255,0.00027117203,0.00069136726,0.000038266637],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00037528717,0.00014814582,0.000015363323,0.007908188,0.0018426053,0.0018229516,0.00038803174,0.000012411563,0.32782087,0.000041457475,0.18150008,0.47812462],"study_design_scores_gemma":[0.00033732745,0.00015792929,2.68754e-7,0.0044267206,0.00023193566,0.00014395591,0.00018075905,8.121257e-7,0.0077952426,0.000008218172,0.9864168,0.00030003602],"about_ca_topic_score_codex":9.2723775e-7,"about_ca_topic_score_gemma":1.1040623e-7,"teacher_disagreement_score":0.80491674,"about_ca_system_score_codex":0.000112117734,"about_ca_system_score_gemma":0.00033144798,"threshold_uncertainty_score":0.99993855},"labels":[],"label_agreement":null},{"id":"W3118628495","doi":"10.1016/j.ejmech.2020.113136","title":"Phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonates and phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonamides as new antimicrotubule agents targeting the colchicine-binding site","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Moiety; Chemistry; Stereochemistry; Docking (animal); Tubulin; Colchicine; Structure–activity relationship; Microtubule; Combinatorial chemistry; In vitro; Biochemistry","score_opus":0.019142159557353558,"score_gpt":0.23690890127525813,"score_spread":0.21776674171790456,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3118628495","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96030045,0.0062509933,0.00006379074,0.0033256393,0.00029351065,0.00006987045,0.000041619696,0.00006227605,0.029591875],"genre_scores_gemma":[0.990161,0.0019671412,0.00052286405,0.0009486285,0.0032294956,0.0000016420084,0.000044909466,0.00009163505,0.003032701],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.995662,0.00037430343,0.0014677002,0.0007141592,0.0009964539,0.0007853967],"domain_scores_gemma":[0.9959721,0.00090756477,0.001358325,0.0005260264,0.00040662085,0.00082939473],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0024714686,0.00065742305,0.0010116528,0.000057987043,0.0005102502,0.00023231517,0.00077450805,0.00019649448,0.0033288882],"category_scores_gemma":[0.0036274854,0.0004379319,0.00045386213,0.00032024414,0.00031759482,0.00023750585,0.00048162974,0.0013989477,0.00006946413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00031865347,0.00018259214,0.0042609903,0.00027685368,0.00023992138,0.0019483742,0.0004374477,0.000021716081,0.97391975,0.000007896933,0.01040437,0.007981433],"study_design_scores_gemma":[0.0022242055,0.000122064484,0.0018334332,0.0011461142,0.0003133345,0.003261018,0.0019988436,0.000083038285,0.9325,0.00015169634,0.05579258,0.00057366554],"about_ca_topic_score_codex":0.000027290384,"about_ca_topic_score_gemma":0.0000018917103,"teacher_disagreement_score":0.04538821,"about_ca_system_score_codex":0.0001308278,"about_ca_system_score_gemma":0.00038083157,"threshold_uncertainty_score":0.99980724},"labels":[],"label_agreement":null},{"id":"W3122146924","doi":"10.1016/j.ejmech.2021.113195","title":"Modulators of CFTR. Updates on clinical development and future directions","year":2021,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Association Vaincre la Mucoviscidose; Cystic Fibrosis Canada","keywords":"Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Potentiator; Limiting; Regulator; Chemistry; Mutation; Population; Clinical trial; Genetic enhancement; Transmembrane protein; Bioinformatics; Gene; Pharmacology; Cancer research; Internal medicine; Medicine; Biology; Biochemistry; Receptor","score_opus":0.06394825971349669,"score_gpt":0.40195227767791175,"score_spread":0.33800401796441504,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3122146924","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0016408815,0.9948391,0.000015109011,0.00018622004,0.00038831934,0.00011394052,0.000009683958,0.000008418358,0.0027983466],"genre_scores_gemma":[0.00012559717,0.99287105,0.003259762,0.00003128245,0.003207974,0.0000012308072,0.000037135396,0.000054904085,0.0004110752],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.996385,0.00037330503,0.0018484505,0.00029685395,0.0008725594,0.00022386468],"domain_scores_gemma":[0.9972392,0.0004296136,0.0011143126,0.00031214216,0.00036121212,0.00054352003],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0020270364,0.00032166258,0.0021077257,0.00012678112,0.000052128657,0.000013993832,0.00024074878,0.000113665854,0.00022232436],"category_scores_gemma":[0.0013907774,0.00021410763,0.00046494277,0.00025375254,0.0002575294,0.00003300898,0.000104490755,0.0016293336,0.000007785908],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00008075792,0.00016583956,0.000032178217,0.010250134,0.0005469221,0.001484382,0.000051968054,1.13513366e-7,0.000040222996,0.0000018398102,0.0022231922,0.98512244],"study_design_scores_gemma":[0.0007211686,0.00046543282,0.00020684204,0.041572955,0.0006964308,0.0034056173,0.00016461193,3.2199688e-7,0.00021474271,7.214375e-7,0.9524134,0.00013779175],"about_ca_topic_score_codex":1.9112943e-7,"about_ca_topic_score_gemma":6.055561e-8,"teacher_disagreement_score":0.98498464,"about_ca_system_score_codex":0.00010903649,"about_ca_system_score_gemma":0.001007745,"threshold_uncertainty_score":0.8731055},"labels":[],"label_agreement":null},{"id":"W3128384845","doi":"10.1016/j.ejmech.2021.113257","title":"Faropenem reacts with serine and metallo-β-lactamases to give multiple products","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Cancer Research UK; National Institutes of Health; Medical Research Council; Diamond Light Source; Wellcome Trust","keywords":"Chemistry; Imine; Stereochemistry; Ring (chemistry); Carbapenem; Serine hydrolase; Tetrahydrofuran; Beta-Lactamase Inhibitors; Enamine; Hydrolysis; Bicyclic molecule; Substrate (aquarium); Serine; Antibiotics; Catalysis; Enzyme; Organic chemistry; Biochemistry","score_opus":0.008661495145868238,"score_gpt":0.2141788684820793,"score_spread":0.20551737333621106,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3128384845","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993912,0.0012766335,0.00034225467,0.00091098854,0.00008897842,0.000051692856,0.00000577819,0.0000043605364,0.0034073282],"genre_scores_gemma":[0.99167234,0.00026908552,0.005323005,0.00028563876,0.0007541446,3.0157128e-7,0.000020922662,0.000034838828,0.001639715],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.998845,0.00010258126,0.0003280815,0.00028552252,0.000247657,0.00019119962],"domain_scores_gemma":[0.9987842,0.00001916903,0.00023973142,0.00029188776,0.00041774125,0.00024726664],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042951273,0.00017511495,0.00024460946,0.00001766663,0.000043174718,0.00003257327,0.00020021743,0.000030883064,0.00003823415],"category_scores_gemma":[0.0009049477,0.00013222978,0.000041674077,0.00010100622,0.00010989003,0.000008649239,0.00012643503,0.00017717369,0.0000037067434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005178337,0.000051650542,0.003214482,0.00010027125,0.00010803136,0.0014225849,0.000059262933,0.0000075969497,0.9910697,5.7479804e-7,0.001997779,0.0014502624],"study_design_scores_gemma":[0.0010869952,0.00046611147,0.020471497,0.00026673815,0.000067671506,0.0032757916,0.0005515075,8.706443e-7,0.90367395,9.350251e-7,0.06996272,0.00017521705],"about_ca_topic_score_codex":0.000001366829,"about_ca_topic_score_gemma":0.00000289825,"teacher_disagreement_score":0.08739572,"about_ca_system_score_codex":0.000013588432,"about_ca_system_score_gemma":0.00016811653,"threshold_uncertainty_score":0.5392174},"labels":[],"label_agreement":null},{"id":"W3128424584","doi":"10.1016/j.ejmech.2021.113282","title":"An insight into the anticancer potential of carbamates and thiocarbamates of 10-demethoxy-10-methylaminocolchicine","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Colchicine; Cytotoxicity; Thiocarbamate; Pharmacology; Carbamate; Cisplatin; Stereochemistry; Thiocarbamates; Doxorubicin; Mechanism of action; IC50; In vitro; Biochemistry; Chemotherapy; Organic chemistry","score_opus":0.012311856500329735,"score_gpt":0.24605161577213108,"score_spread":0.23373975927180135,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3128424584","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9805803,0.005604601,0.000041196396,0.00044763106,0.000048567203,0.000019167364,0.00000812785,0.0000072994408,0.01324312],"genre_scores_gemma":[0.99781084,0.0006643289,0.00055686285,0.000048879458,0.0005950227,4.5600424e-7,0.000004884737,0.000017417144,0.0003013109],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99818593,0.00026753667,0.0007233378,0.00020762214,0.00044714045,0.00016842067],"domain_scores_gemma":[0.9979955,0.0003863824,0.0007332665,0.0003018761,0.0004353793,0.00014760914],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0013501373,0.0001901088,0.00053652754,0.000020731051,0.00006243337,0.000017692017,0.00039375483,0.00007384791,0.0023514372],"category_scores_gemma":[0.0009587662,0.00010754908,0.00014877248,0.00011957547,0.00046366692,0.00006706826,0.00011720656,0.00038497188,0.0000010135424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00023534415,0.00016631327,0.0017194955,0.0003431028,0.00013117255,0.00020327128,0.0004427322,0.0000055437245,0.9797103,0.000003839033,0.00010231271,0.016936593],"study_design_scores_gemma":[0.00065360696,0.00018383925,0.006858483,0.0004001234,0.00018234756,0.00029672144,0.0013889029,0.00004475172,0.98755485,0.000055950884,0.0022651514,0.00011528996],"about_ca_topic_score_codex":0.000008899149,"about_ca_topic_score_gemma":5.488829e-7,"teacher_disagreement_score":0.017230548,"about_ca_system_score_codex":0.000018337467,"about_ca_system_score_gemma":0.00008869105,"threshold_uncertainty_score":0.99856055},"labels":[],"label_agreement":null},{"id":"W3133833201","doi":"10.1016/j.ejmech.2021.113339","title":"Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Canada; Deutscher Akademischer Austauschdienst; University of Sharjah","keywords":"Chemistry; Docking (animal); Cytotoxicity; IC50; Biochemistry; Hypophosphatasia; Phosphodiesterase; Lead compound; Pyrophosphatases; Isozyme; Enzyme; Sulfonylurea; Stereochemistry; Pharmacology; Alkaline phosphatase; In vitro; Diabetes mellitus; Biology","score_opus":0.046965270070227605,"score_gpt":0.3180217117579307,"score_spread":0.2710564416877031,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3133833201","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9476272,0.05156722,0.00012325443,0.00029142055,0.000077903365,0.000051601775,0.000012005934,0.0000028280006,0.00024655543],"genre_scores_gemma":[0.9936311,0.005124123,0.00054460845,0.0001891626,0.00045376268,0.0000013739887,0.000016079654,0.000017731272,0.000022012098],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.998562,0.00020330865,0.00053470844,0.00026057925,0.00028520048,0.00015419784],"domain_scores_gemma":[0.99865067,0.00012476843,0.00045308468,0.00013206893,0.0005053476,0.0001340563],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011418359,0.00019403915,0.00035795834,0.000022430242,0.00008995466,0.000017573286,0.00011393674,0.000047496018,0.00004315842],"category_scores_gemma":[0.0024655624,0.00014878543,0.00006799142,0.00008533294,0.00032823754,0.000012279819,0.00017328098,0.00017215744,2.6984537e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027675394,0.000107521504,0.005230657,0.00012445413,0.0003758233,0.00030850747,0.0005188201,0.00011718442,0.9898392,0.0000041209405,0.0016147888,0.0014821886],"study_design_scores_gemma":[0.0014991245,0.00035324227,0.003936275,0.00049462897,0.00014299435,0.0007852493,0.0025188643,0.000042839143,0.9888902,0.000014832511,0.0011631298,0.00015867325],"about_ca_topic_score_codex":0.0000013370279,"about_ca_topic_score_gemma":1.400418e-7,"teacher_disagreement_score":0.046443097,"about_ca_system_score_codex":0.000013020972,"about_ca_system_score_gemma":0.00011932767,"threshold_uncertainty_score":0.6067294},"labels":[],"label_agreement":null},{"id":"W3147117676","doi":"10.1016/j.ejmech.2021.113436","title":"A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Pseudomonas aeruginosa; Microbiology; Klebsiella pneumoniae; Acinetobacter baumannii; Meropenem; Carbapenem; Chemistry; Antibiotics; Multiple drug resistance; Antimicrobial; Minimum inhibitory concentration; Biology; Antibiotic resistance; Bacteria; Escherichia coli; Biochemistry","score_opus":0.005496799538225914,"score_gpt":0.21917412376485135,"score_spread":0.21367732422662544,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3147117676","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9885245,0.0039271885,0.00020143205,0.0003421869,0.00028338472,0.000101196725,0.000016484271,0.000009389018,0.00659424],"genre_scores_gemma":[0.9951427,0.0014679331,0.00096932234,0.0003053581,0.0011328175,3.847942e-7,0.000039964892,0.00006713674,0.00087439816],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.997686,0.0003386269,0.0007035151,0.0004831875,0.00039854905,0.00039011863],"domain_scores_gemma":[0.9981914,0.00007369969,0.0005372016,0.0004523826,0.00038659127,0.00035872794],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000730345,0.00036961425,0.00049288815,0.000039708208,0.00010050075,0.000068679015,0.0003282991,0.00011864279,0.00005500903],"category_scores_gemma":[0.00064309494,0.00031807247,0.00020201613,0.00012800047,0.00032255784,0.000013396426,0.00019846913,0.00048708936,0.000012489719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004002792,0.00010197691,0.007358414,0.00022150854,0.00019558253,0.003197791,0.00008648306,0.000008691945,0.98314995,0.0000010850929,0.0018423666,0.0034359025],"study_design_scores_gemma":[0.0025044358,0.0004554013,0.064476505,0.000816376,0.00015454166,0.0027155087,0.0007908393,0.000013264077,0.91400236,0.0000053907133,0.013636194,0.0004291916],"about_ca_topic_score_codex":0.0000013408227,"about_ca_topic_score_gemma":0.0000019662375,"teacher_disagreement_score":0.069147564,"about_ca_system_score_codex":0.000046653146,"about_ca_system_score_gemma":0.00018524067,"threshold_uncertainty_score":0.99992716},"labels":[],"label_agreement":null},{"id":"W3156952872","doi":"10.1016/j.ejmech.2021.113456","title":"First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward","year":2021,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Dendrimers and Hyperbranched Polymers","field":"Materials Science","cited_by":32,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Agência Regional para o Desenvolvimento da Investigação, Tecnologia e Inovação; National Natural Science Foundation of China; European Commission; Centre National de la Recherche Scientifique; EuroNanoMed III; University of Toronto","keywords":"Dendrimer; Nanocarriers; Nanomedicine; Nanotechnology; Class (philosophy); Biocompatibility; Chemistry; Computer science; Drug delivery; Materials science; Artificial intelligence; Organic chemistry; Nanoparticle","score_opus":0.0637282375181226,"score_gpt":0.3407966600415294,"score_spread":0.2770684225234068,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3156952872","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0129481545,0.98040134,0.000033043965,0.00045983496,0.0010699824,0.00015612226,0.000074521246,0.00001160039,0.0048454218],"genre_scores_gemma":[0.004338084,0.9911533,0.0006726681,0.0001970077,0.0017250216,0.0000047034923,0.000033553562,0.00013437409,0.0017412982],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99560773,0.0003383416,0.0020043687,0.0006915682,0.00073398865,0.0006239939],"domain_scores_gemma":[0.99711657,0.00052139733,0.0011740075,0.00046346211,0.000109289045,0.00061528775],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0018044888,0.0005909617,0.0025809577,0.00017847147,0.00009246526,0.00013977839,0.00091162923,0.00022214475,0.0013835347],"category_scores_gemma":[0.0005939591,0.00046610174,0.0004352159,0.00033215721,0.00022845123,0.00018696998,0.00032162154,0.0014388411,0.0001563173],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002270215,0.0004141176,0.00009381121,0.007344414,0.00041467708,0.020940961,0.0033983407,0.00004273438,0.017170226,0.000010942786,0.0063774167,0.9435653],"study_design_scores_gemma":[0.0015736704,0.00020612434,0.000018515184,0.040120546,0.0006544794,0.00093321636,0.0012129074,0.0000040600426,0.0030007868,0.00000887604,0.95164746,0.00061933656],"about_ca_topic_score_codex":0.000041857107,"about_ca_topic_score_gemma":0.00002271733,"teacher_disagreement_score":0.94527006,"about_ca_system_score_codex":0.00020000142,"about_ca_system_score_gemma":0.0005531578,"threshold_uncertainty_score":0.99977905},"labels":[],"label_agreement":null},{"id":"W3158447546","doi":"10.1016/j.ejmech.2021.113496","title":"Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Chemistry; LNCaP; DU145; Androstenedione; Dimer; Cyproterone acetate; Stereochemistry; Androgen; Testosterone (patch); Dihydrotestosterone; Prostate cancer; Internal medicine; Endocrinology; Biochemistry; Hormone; Organic chemistry; Cancer; Biology","score_opus":0.0753581297433195,"score_gpt":0.3165685419137277,"score_spread":0.24121041217040817,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3158447546","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9852285,0.01154351,0.000020414123,0.0019272474,0.00015721231,0.00028747923,0.0000039290603,0.0000067072187,0.00082501397],"genre_scores_gemma":[0.99642056,0.0022775985,0.00041378484,0.000115468385,0.00047559777,0.000007225731,0.0000026411974,0.000017235985,0.0002698613],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.99819005,0.00034656856,0.0004680452,0.0003330206,0.0004911772,0.00017111741],"domain_scores_gemma":[0.998169,0.00024011152,0.00027238837,0.00011638045,0.001009796,0.00019232943],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00252294,0.00018691907,0.0004627636,0.0000876468,0.0001056756,0.000016576409,0.00005650218,0.000022565171,0.000036919682],"category_scores_gemma":[0.002534737,0.000114271454,0.000029719964,0.0004731186,0.00010866388,0.000051266317,0.00009485045,0.00031142557,0.0000019500283],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002341863,0.0014145593,0.05443727,0.00025565716,0.00047499148,0.0021678237,0.0042517167,0.000011578029,0.8239693,4.746426e-7,0.0007487305,0.10992604],"study_design_scores_gemma":[0.0064248187,0.010117448,0.47448003,0.0022856405,0.00080076494,0.0016667725,0.029581299,0.000018272713,0.47376287,0.000010337113,0.0004812812,0.0003704706],"about_ca_topic_score_codex":0.0000031167406,"about_ca_topic_score_gemma":3.9985196e-7,"teacher_disagreement_score":0.42004275,"about_ca_system_score_codex":0.00009073769,"about_ca_system_score_gemma":0.00012677346,"threshold_uncertainty_score":0.46598545},"labels":[],"label_agreement":null},{"id":"W3166210850","doi":"10.1016/j.ejmech.2021.113565","title":"Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Krembil Foundation","keywords":"Neuroinflammation; Chemistry; Microglia; Proinflammatory cytokine; Downregulation and upregulation; Pharmacology; Furosemide; Nitric oxide; Neuroprotection; Cell biology; Biochemistry; Inflammation; Immunology; Biology","score_opus":0.10224871318362135,"score_gpt":0.34542794919518116,"score_spread":0.24317923601155983,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3166210850","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8064546,0.1918782,0.0003391596,0.00073828746,0.000023723238,0.00036216338,0.00001770271,0.000003019092,0.0001831492],"genre_scores_gemma":[0.9954491,0.0038839267,0.00044525822,0.00006414183,0.00012168239,0.000009355465,0.0000074161144,0.000014997715,0.0000040806985],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982228,0.00042773134,0.00043976886,0.00014498281,0.00062097557,0.00014371243],"domain_scores_gemma":[0.99795735,0.00045530344,0.00035349384,0.00019366083,0.00077897636,0.00026122172],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0024730354,0.00012887135,0.00031995954,0.000028897884,0.000060760707,0.0000090205285,0.00009337357,0.000026776657,0.000053353382],"category_scores_gemma":[0.0012914132,0.00007391758,0.0001079131,0.000081519975,0.0003283288,0.000033516855,0.000043922337,0.00017379904,4.3600687e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0159872,0.0021618032,0.03582631,0.0011729966,0.02322357,0.0031290741,0.001027069,0.000034731427,0.672478,0.000025147754,0.00023122635,0.24470285],"study_design_scores_gemma":[0.010292245,0.002750443,0.2442272,0.001998408,0.020056222,0.002252606,0.0021811544,0.00079948833,0.7144405,0.0005371832,0.00022652638,0.0002379909],"about_ca_topic_score_codex":9.716633e-7,"about_ca_topic_score_gemma":2.2701986e-8,"teacher_disagreement_score":0.24446486,"about_ca_system_score_codex":0.000018859448,"about_ca_system_score_gemma":0.0005482522,"threshold_uncertainty_score":0.30142716},"labels":[],"label_agreement":null},{"id":"W3167205542","doi":"10.1016/j.ejmech.2021.113584","title":"Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies","year":2021,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":96,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Drug; Protease; Coronavirus; Antiviral drug; 2019-20 coronavirus outbreak; Virology; Solubility; Coronavirus disease 2019 (COVID-19); Pharmacology; Enzyme inhibitor; Viral replication; Enzyme; Biochemistry; Virus; Organic chemistry; Infectious disease (medical specialty)","score_opus":0.05471483860192277,"score_gpt":0.3688288980158104,"score_spread":0.31411405941388765,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3167205542","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0063292887,0.9850055,0.0066476166,0.0002596739,0.0011090114,0.00023829803,0.000020017875,0.0000328097,0.00035781454],"genre_scores_gemma":[0.010630934,0.9551762,0.030037118,0.00060337,0.0032287831,0.0000055608016,0.00007138915,0.0001297161,0.000116964264],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99395716,0.001953959,0.0018087887,0.00077953545,0.0011030604,0.00039749534],"domain_scores_gemma":[0.99560225,0.0011534664,0.0018599713,0.0006384468,0.0005444528,0.00020143151],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0044627003,0.00071212614,0.0020571447,0.00018620076,0.00015075653,0.00018542242,0.0013200289,0.00008417231,0.0000076199794],"category_scores_gemma":[0.0013414414,0.0005434623,0.0005557129,0.0004635338,0.0002751947,0.00024076519,0.00072938605,0.0013137603,0.0000031095474],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00007004104,0.00015951206,0.000007367927,0.013405213,0.0006457375,0.0020005729,0.00031407096,0.000041156723,0.0048266184,0.000008531909,0.002608461,0.9759127],"study_design_scores_gemma":[0.011159685,0.001970187,0.00007290054,0.1796992,0.0044872956,0.004877183,0.00070984353,0.031819806,0.13353857,0.0003761402,0.6262166,0.005072627],"about_ca_topic_score_codex":0.0000031539098,"about_ca_topic_score_gemma":4.374589e-7,"teacher_disagreement_score":0.9708401,"about_ca_system_score_codex":0.0002641747,"about_ca_system_score_gemma":0.00090429303,"threshold_uncertainty_score":0.9997017},"labels":[],"label_agreement":null},{"id":"W3170700266","doi":"10.1016/j.ejmech.2021.113639","title":"Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise","year":2021,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"Camptothecin; Irinotecan; Topotecan; Chemistry; Topoisomerase; Pharmacology; Natural product; Drug discovery; Prodrug; Cancer; Medicine; In vitro; Chemotherapy; Biochemistry","score_opus":0.027174978491652253,"score_gpt":0.3154622922771707,"score_spread":0.2882873137855185,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3170700266","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0041186432,0.99246585,0.0013098314,0.00009925427,0.0007303236,0.00014571568,0.00011327357,0.000002979812,0.0010141194],"genre_scores_gemma":[0.0014446189,0.9910334,0.00028998975,0.00016835639,0.005532264,0.000002435928,0.00016101157,0.00010998039,0.0012579575],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9971527,0.00029948162,0.0012734509,0.00040896094,0.0005954523,0.0002699592],"domain_scores_gemma":[0.9973781,0.00005596329,0.0013598771,0.0005793368,0.00026437835,0.00036231737],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00097470015,0.00040345834,0.0016183088,0.000076107135,0.00003180588,0.000028812346,0.00080586923,0.0001732568,0.00025710845],"category_scores_gemma":[0.00033371887,0.000325516,0.00064409047,0.0001667078,0.0001417016,0.000006569277,0.00023252438,0.000595975,0.000003925353],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025136356,0.00015043172,0.000002473571,0.0036647976,0.001671059,0.0012431972,0.00037725084,0.0000063987004,0.18867806,0.000007102293,0.01754126,0.7864066],"study_design_scores_gemma":[0.0009307592,0.00045297516,0.0000058515284,0.018823385,0.0010966291,0.0005226906,0.00016161727,2.0534851e-7,0.01790245,0.000006615444,0.95979464,0.00030219785],"about_ca_topic_score_codex":0.000009670725,"about_ca_topic_score_gemma":0.0000011915569,"teacher_disagreement_score":0.94225335,"about_ca_system_score_codex":0.000056345492,"about_ca_system_score_gemma":0.00069983467,"threshold_uncertainty_score":0.9999197},"labels":[],"label_agreement":null},{"id":"W3191772077","doi":"10.1016/j.ejmech.2021.113753","title":"Strategies in the design and development of (TAR) DNA-binding protein 43 (TDP-43) binding ligands","year":2021,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; University of Waterloo","funders":"","keywords":"Chemistry; Frontotemporal dementia; Computational biology; Amyotrophic lateral sclerosis; Oligonucleotide; RNA; Binding domain; Binding site; Small molecule; Neurodegeneration; Structural motif; Function (biology); DNA; Cell biology; Biochemistry; Dementia; Disease; Biology; Medicine; Gene","score_opus":0.11753990984472766,"score_gpt":0.3504756259372259,"score_spread":0.23293571609249825,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3191772077","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.08117921,0.9160771,0.00021816863,0.00019651215,0.000060789982,0.00059883035,0.0000031130996,0.000008294926,0.0016579919],"genre_scores_gemma":[0.0190109,0.97541195,0.0041598435,0.00002327242,0.00079859165,0.0000135874,0.000032437256,0.000105918494,0.00044348923],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.995461,0.00069831253,0.0017910836,0.0003157786,0.0013130144,0.00042081458],"domain_scores_gemma":[0.9977934,0.00029866686,0.0011012855,0.0003071154,0.00022145665,0.00027812883],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0061597996,0.0004245902,0.0017792595,0.00021114788,0.000094586576,0.000075750235,0.0006038288,0.00014266076,0.0001637621],"category_scores_gemma":[0.00050515146,0.0002447124,0.00024068372,0.00044879082,0.00022149639,0.00009482124,0.00017171341,0.0019844756,0.0000075567923],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00027452197,0.00036514667,0.00003722485,0.05463092,0.0010245938,0.015102977,0.003549268,0.0000031015154,0.09958665,0.00000853149,0.0008523606,0.8245647],"study_design_scores_gemma":[0.0053328136,0.0013565853,0.0002511199,0.44012246,0.0015165315,0.015636582,0.00895494,0.000007114246,0.022125438,0.000007245349,0.5037028,0.0009863405],"about_ca_topic_score_codex":9.480901e-7,"about_ca_topic_score_gemma":1.2858607e-7,"teacher_disagreement_score":0.82357836,"about_ca_system_score_codex":0.0002857137,"about_ca_system_score_gemma":0.002043255,"threshold_uncertainty_score":0.9979082},"labels":[],"label_agreement":null},{"id":"W3195535935","doi":"10.1016/j.ejmech.2021.113793","title":"Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ontario Ministry of Research, Innovation and Science; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Corporation for National and Community Service","keywords":"Neuropathic pain; Chemistry; Pharmacology; Cisplatin; Oxaliplatin; Doxorubicin; Peripheral neuropathy; Carbonic anhydrase; Chemotherapy; Cancer; Enzyme; Medicine; Biochemistry; Colorectal cancer; Internal medicine","score_opus":0.018252087921603148,"score_gpt":0.24818157003259864,"score_spread":0.22992948211099548,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3195535935","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99312794,0.0008103186,0.0009609281,0.00027195545,0.00035579572,0.000048829203,0.000004242353,0.000009864838,0.0044101314],"genre_scores_gemma":[0.9972331,0.00024138988,0.00021604532,0.0004019778,0.0015606604,7.4976884e-7,0.000040829676,0.000030688676,0.00027454615],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983754,0.00037592865,0.00054460973,0.00027803282,0.00026024738,0.00016578082],"domain_scores_gemma":[0.9986671,0.000028800789,0.0005339711,0.00017486374,0.000396059,0.00019920761],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007410496,0.00019096193,0.00023589745,0.000031703174,0.000120632205,0.000032100455,0.00008650432,0.00007199401,0.00003749111],"category_scores_gemma":[0.0007455231,0.00017685177,0.00010348372,0.00012566564,0.00008228319,0.000018133669,0.0000616243,0.00044475234,0.0000024810756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018851455,0.000039818595,0.0002636381,0.000043088276,0.00004807755,0.00036741293,0.00009493824,0.000009450071,0.99609935,0.0000014731758,0.0008440627,0.0020001438],"study_design_scores_gemma":[0.0016050114,0.0005167952,0.0007378476,0.00021085587,0.000054633794,0.0016275399,0.00075963157,0.00004319067,0.993426,0.0000055615556,0.00084393343,0.00016897553],"about_ca_topic_score_codex":9.862446e-7,"about_ca_topic_score_gemma":0.0000016145515,"teacher_disagreement_score":0.004135585,"about_ca_system_score_codex":0.000026960164,"about_ca_system_score_gemma":0.00017938699,"threshold_uncertainty_score":0.7211806},"labels":[],"label_agreement":null},{"id":"W3202255502","doi":"10.1016/j.ejmech.2021.113904","title":"Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Ministry of Science and Technology, Taiwan; Ministère de l’Éducation, Gouvernement de l’Ontario; Academia Sinica","keywords":"Chemistry; Moiety; Tertiary amine; Kinase; Oxime; Phosphorylation; Cell growth; Stereochemistry; Biochemistry; Cancer research; Biology","score_opus":0.04930595890444262,"score_gpt":0.29393014267311157,"score_spread":0.24462418376866896,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3202255502","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99260736,0.0032189942,0.0015570283,0.00010305989,0.00009561887,0.000054103177,0.0000035764397,0.000003619317,0.0023566252],"genre_scores_gemma":[0.9967512,0.00097379024,0.0017480524,0.00017223562,0.00025332748,0.0000013575145,0.00000875718,0.000018033135,0.000073262716],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982312,0.00057735166,0.0003918108,0.00021702236,0.0004410335,0.00014163066],"domain_scores_gemma":[0.9987557,0.000065920736,0.00035170963,0.00018948661,0.0005107848,0.00012642577],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017314072,0.00014065069,0.0002356021,0.000023079243,0.00003806471,0.000011503924,0.0001739375,0.000056857494,0.00014493681],"category_scores_gemma":[0.0019302536,0.00011404747,0.00008483059,0.00007474765,0.00015357495,0.000005867134,0.00009876802,0.00012153743,0.0000016473454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015604268,0.00007811211,0.0003479899,0.000037117537,0.000113212875,0.0002050972,0.00006371887,0.000055253593,0.98477465,7.664604e-7,0.00035109054,0.013816947],"study_design_scores_gemma":[0.00087057595,0.00030367018,0.0020519884,0.0002347554,0.00011512897,0.00044197965,0.00051256584,0.00005478631,0.9944401,0.000028516464,0.0008335993,0.00011237387],"about_ca_topic_score_codex":3.6938906e-7,"about_ca_topic_score_gemma":8.324091e-8,"teacher_disagreement_score":0.013704574,"about_ca_system_score_codex":0.000020722473,"about_ca_system_score_gemma":0.00023373523,"threshold_uncertainty_score":0.46507207},"labels":[],"label_agreement":null},{"id":"W3215238985","doi":"10.1016/j.ejmech.2021.114003","title":"Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital Saint-François d'Assise","funders":"Centre Hospitalier Universitaire de Québec; Merck Sharp and Dohme; Université Laval","keywords":"Chemistry; Moiety; Stereochemistry; Prodrug; Cytochrome P450; Alkyl; Isopropyl; Selectivity; Enzyme; Biochemistry; Medicinal chemistry; Organic chemistry","score_opus":0.03217680302786162,"score_gpt":0.25835554956111795,"score_spread":0.22617874653325631,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3215238985","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.992094,0.00083024264,0.00015470565,0.0003546283,0.000051079667,0.000077197416,0.000017445038,0.000019772342,0.006400968],"genre_scores_gemma":[0.99857515,0.00047203168,0.00045972242,0.000044566725,0.00034811566,0.0000019173697,0.000031420892,0.000024461613,0.000042597592],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.997255,0.0004082713,0.001018287,0.0003716577,0.000701766,0.00024498822],"domain_scores_gemma":[0.9968064,0.0004821887,0.0013521414,0.00027425657,0.0008991987,0.0001858221],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0020631775,0.00028970552,0.0007177989,0.000053388845,0.00006276662,0.000018566583,0.00029753754,0.00017978107,0.0011404325],"category_scores_gemma":[0.0031162768,0.00020754374,0.00019023349,0.00024085662,0.00025900203,0.00012561628,0.0001190073,0.0004899557,0.0000015604413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00042371388,0.00037557358,0.00046052726,0.00033452225,0.00017139743,0.00012734866,0.00014771336,0.000009075204,0.98682076,0.000032896056,0.000018375024,0.011078084],"study_design_scores_gemma":[0.0014453107,0.00023632367,0.0064509613,0.0008019438,0.00015346888,0.00065417273,0.0008835595,0.000092461,0.98838776,0.0005866531,0.000099635654,0.00020776685],"about_ca_topic_score_codex":0.0000050493877,"about_ca_topic_score_gemma":1.787895e-7,"teacher_disagreement_score":0.010870317,"about_ca_system_score_codex":0.000080628764,"about_ca_system_score_gemma":0.00023215078,"threshold_uncertainty_score":0.99977267},"labels":[],"label_agreement":null},{"id":"W383619729","doi":"10.1016/j.ejmech.2015.05.034","title":"Styryl-N-phenyl-N′-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Moiety; Chemistry; Combretastatin; Stereochemistry; Tubulin; Ring (chemistry); Microtubule; Biological activity; In vitro; Organic chemistry; Biochemistry","score_opus":0.09922953528473295,"score_gpt":0.30171108899952603,"score_spread":0.2024815537147931,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W383619729","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97569156,0.0018536086,0.0007566572,0.0007602345,0.000108641725,0.00004831307,0.000013432127,0.00003883973,0.020728724],"genre_scores_gemma":[0.9938464,0.00016324807,0.0034524065,0.00039212257,0.0012441551,4.7082756e-7,0.000008126302,0.000061787345,0.0008312833],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9970831,0.00015751855,0.0009536094,0.00042911514,0.0008681985,0.00050840614],"domain_scores_gemma":[0.99676937,0.00018656404,0.0009762635,0.0003081062,0.00029300287,0.0014666871],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0016904218,0.00045230615,0.0006800164,0.00004523921,0.00014705444,0.0000980053,0.00055678166,0.00012394108,0.00051549583],"category_scores_gemma":[0.0019594918,0.00034048918,0.00020885756,0.00010605435,0.00023986051,0.00018057997,0.00027180946,0.0008556295,0.000023003633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00082739524,0.0002685884,0.0014643023,0.00022958069,0.00020396289,0.001628138,0.00083646324,0.00055365264,0.9664303,0.000009206656,0.0016412464,0.025907168],"study_design_scores_gemma":[0.007342079,0.0005425895,0.0006018447,0.0021866912,0.00067273434,0.0126901865,0.0072503923,0.008610498,0.9505085,0.001375491,0.00694678,0.0012722329],"about_ca_topic_score_codex":0.000053282463,"about_ca_topic_score_gemma":4.394077e-7,"teacher_disagreement_score":0.024634937,"about_ca_system_score_codex":0.00016676415,"about_ca_system_score_gemma":0.00045747022,"threshold_uncertainty_score":0.9999047},"labels":[],"label_agreement":null},{"id":"W4200510858","doi":"10.1016/j.ejmech.2021.114046","title":"Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors","year":2021,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":76,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Covalent bond; Coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); In vitro; Enzyme; Protease; Virology; Coronavirus disease 2019 (COVID-19); Viral replication; Cysteine protease; Antiviral drug; Biochemistry; Virus; Pharmacology; Biology; Medicine","score_opus":0.07775702948753731,"score_gpt":0.3070640339878582,"score_spread":0.22930700450032088,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4200510858","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98852044,0.0012972256,0.00071290584,0.00043059912,0.000033603188,0.000034577915,0.000011921487,0.0000074950476,0.008951236],"genre_scores_gemma":[0.99795955,0.00011363977,0.0014321107,0.000037484566,0.00035375546,0.0000041621315,0.0000086207465,0.000023373446,0.000067293084],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9979745,0.0001004523,0.00082700717,0.00022721822,0.0007016142,0.00016919276],"domain_scores_gemma":[0.9983026,0.00027999774,0.0005840288,0.000264006,0.0004675078,0.00010186844],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021320274,0.0001701398,0.0003341442,0.00003036022,0.000039208375,0.00001570652,0.00022095777,0.00006228553,0.0001950293],"category_scores_gemma":[0.0013650836,0.0001639222,0.000093819246,0.00016982039,0.00013664395,0.000059319063,0.000067621535,0.00041888698,0.0000013485438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00015381178,0.0002669858,0.00007030363,0.00029925353,0.00004784514,0.00011472433,0.0001581659,0.00006816944,0.99155855,6.5510955e-7,0.0002843631,0.0069771465],"study_design_scores_gemma":[0.001735909,0.000008362991,0.00008825165,0.0006461428,0.00019811447,0.000781867,0.00059400016,0.0003921472,0.99477464,0.000022075414,0.00062452856,0.00013395246],"about_ca_topic_score_codex":0.000001424759,"about_ca_topic_score_gemma":1.5964171e-7,"teacher_disagreement_score":0.009439124,"about_ca_system_score_codex":0.000104482446,"about_ca_system_score_gemma":0.0002627109,"threshold_uncertainty_score":0.66845536},"labels":[],"label_agreement":null},{"id":"W4210333340","doi":"10.1016/j.ejmech.2022.114162","title":"Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"University of Leicester; Higher Education Commision, Pakistan; McGill University; University of Missouri","keywords":"Adamantane; Chemistry; Moiety; Pharmacology; Allosteric regulation; IC50; Stereochemistry; Receptor; Allosteric modulator; Lead compound; Structure–activity relationship; Biochemistry; In vitro; Medicine","score_opus":0.012779236203458158,"score_gpt":0.24137518909069552,"score_spread":0.22859595288723736,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4210333340","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99348235,0.0053436514,0.000815545,0.00018553738,0.000018506447,0.00010859481,0.0000038374224,0.0000014590565,0.00004054499],"genre_scores_gemma":[0.9976773,0.0015912574,0.00058345933,0.000013637616,0.00010611492,0.0000034607053,0.000004213622,0.000012617118,0.000007898318],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990644,0.00021806217,0.00034375238,0.00015075627,0.00013603784,0.00008702012],"domain_scores_gemma":[0.99928635,0.00012089308,0.00039872204,0.000064820306,0.000071069626,0.000058150647],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004749444,0.000120807235,0.00023933951,0.00003449647,0.000060294813,0.00000447752,0.000059436526,0.00002932618,0.000005387095],"category_scores_gemma":[0.00011768863,0.0000952282,0.000036856367,0.00004211095,0.00015111343,0.000008503686,0.000043711985,0.00006739221,3.5907766e-9],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013726929,0.00009919147,0.004030526,0.000111861875,0.00017023366,0.000011297769,0.0011808535,0.00020920037,0.9690273,0.0000030024441,0.000026594926,0.023757247],"study_design_scores_gemma":[0.002150654,0.008091811,0.00477601,0.00009392842,0.00025884472,0.00040265734,0.0026805804,0.0004066282,0.9805216,0.00009605529,0.00036234464,0.00015884775],"about_ca_topic_score_codex":0.0000025811764,"about_ca_topic_score_gemma":8.954856e-8,"teacher_disagreement_score":0.0235984,"about_ca_system_score_codex":0.000006260249,"about_ca_system_score_gemma":0.000036380206,"threshold_uncertainty_score":0.38832933},"labels":[],"label_agreement":null},{"id":"W4210569549","doi":"10.1016/j.ejmech.2022.114172","title":"Structure-activity relationships of N-terminal variants of peptidomimetic tissue transglutaminase inhibitors","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Peptidomimetic; Chemistry; Tissue transglutaminase; GTP'; Biochemistry; Enzyme; Allosteric regulation; Stereochemistry; Peptide","score_opus":0.022203949744268058,"score_gpt":0.23880594321216067,"score_spread":0.2166019934678926,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4210569549","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9965193,0.00068411365,0.00026796473,0.00039732803,0.00017686209,0.00008210319,0.00001815148,0.000005289014,0.0018488442],"genre_scores_gemma":[0.99882394,0.00001421689,0.0004477471,0.000025027584,0.0003664,4.6802182e-7,0.0000068434683,0.000024015511,0.00029136348],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9979987,0.00032954,0.00072114734,0.00012447598,0.0006960061,0.00013009834],"domain_scores_gemma":[0.99862903,0.00006758535,0.0007684168,0.00019803965,0.00018553149,0.0001513764],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011604045,0.00013109666,0.0004215778,0.000082654326,0.00008910008,0.000003306982,0.00016412164,0.000030198016,0.0007754904],"category_scores_gemma":[0.00020767808,0.00010897641,0.00012371188,0.0001982235,0.00013287293,0.00006429426,0.000045949535,0.00077650446,6.8488555e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016178556,0.00024746184,0.0030040357,0.00048069615,0.0001059069,0.00072653906,0.0010797827,0.00015866767,0.97846794,0.0000030214053,0.00033089443,0.013777178],"study_design_scores_gemma":[0.0061963466,0.0033513166,0.11650148,0.0008245513,0.0009880344,0.0098151965,0.0021692014,0.00018821863,0.85807747,0.000042161715,0.0016269058,0.00021910995],"about_ca_topic_score_codex":0.0000055669007,"about_ca_topic_score_gemma":1.6542724e-7,"teacher_disagreement_score":0.12039048,"about_ca_system_score_codex":0.000057496916,"about_ca_system_score_gemma":0.00017033303,"threshold_uncertainty_score":0.8491076},"labels":[],"label_agreement":null},{"id":"W4224214069","doi":"10.1016/j.ejmech.2022.114379","title":"Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Hyperuricemia; Xanthine oxidase; Chemistry; Uric acid; Gout; Febuxostat; Allopurinol; Pharmacology; In vivo; Kidney; Purine metabolism; Biochemistry; Fibrosis; Inflammation; Endocrinology; Enzyme; Internal medicine; Medicine; Biology","score_opus":0.025061253687844,"score_gpt":0.25651584703646446,"score_spread":0.23145459334862045,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4224214069","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99068415,0.005874899,0.000013043143,0.00038870153,0.00006132711,0.0001123205,0.0000071013956,0.000007261865,0.0028512075],"genre_scores_gemma":[0.9987508,0.00031726898,0.0005446534,0.00006882689,0.00025642113,0.0000031833054,0.0000031236632,0.000021966516,0.000033733544],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9972704,0.00049103634,0.0008212508,0.00019096203,0.0010765839,0.00014975708],"domain_scores_gemma":[0.9980964,0.00033582147,0.00085364754,0.00018160003,0.0003253898,0.00020713745],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0034173296,0.00016727671,0.00049598643,0.00010557623,0.00007351181,0.000004495437,0.0001507685,0.000044871416,0.000361242],"category_scores_gemma":[0.0023410665,0.000132329,0.00009876603,0.00017061949,0.00036258862,0.000060908264,0.00017574505,0.00048184086,6.9420344e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005905854,0.0001225832,0.033313088,0.00035837066,0.0002488847,0.00022131487,0.0013038724,0.00002462995,0.95170385,0.0000022303745,0.0003420812,0.011768524],"study_design_scores_gemma":[0.0041772113,0.0017991366,0.16508651,0.0009268273,0.0016904036,0.0072433236,0.008324953,0.00010843238,0.8090087,0.00005321491,0.0013379384,0.00024333436],"about_ca_topic_score_codex":0.0000034745515,"about_ca_topic_score_gemma":2.8021649e-8,"teacher_disagreement_score":0.14269511,"about_ca_system_score_codex":0.000088665525,"about_ca_system_score_gemma":0.00023126909,"threshold_uncertainty_score":0.539622},"labels":[],"label_agreement":null},{"id":"W4283071201","doi":"10.1016/j.ejmech.2022.114543","title":"Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Oligopeptidase; Chemistry; Bicyclic molecule; Fibroblast activation protein, alpha; Docking (animal); Drug discovery; Biochemistry; Enzyme; Pharmacology; Stereochemistry; Cancer; Biology; Medicine","score_opus":0.013548121620621403,"score_gpt":0.24643641398051094,"score_spread":0.23288829235988953,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4283071201","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9923591,0.00004309758,0.0037086294,0.0030957588,0.0000131901,0.00047833406,0.000025943209,0.000010002572,0.0002659343],"genre_scores_gemma":[0.9984485,0.0000016419357,0.000510906,0.00011783534,0.00061432365,0.000039115344,0.000029129355,0.000024527242,0.0002140437],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985402,0.00012300746,0.00059973466,0.0001547866,0.00043420013,0.00014805458],"domain_scores_gemma":[0.99847066,0.00016642195,0.00083058345,0.00013510742,0.0002624146,0.00013481741],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011030013,0.00013490746,0.00028610948,0.00009215449,0.00029065058,0.000012500808,0.00010715145,0.000021136855,0.000046404737],"category_scores_gemma":[0.0006262164,0.000092831026,0.00019227942,0.00019636289,0.00011403135,0.00006207847,0.0000585338,0.00038849562,1.17094075e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00047978634,0.0002274543,0.00051628245,0.00048126798,0.000111737936,0.000007046394,0.0005848051,0.000072269315,0.9927405,0.000011576784,0.0013195582,0.0034477315],"study_design_scores_gemma":[0.003884492,0.0013198996,0.0037081013,0.0024214261,0.00020339999,0.00028432335,0.0022555601,0.0010101561,0.98363847,0.000095100884,0.001033651,0.00014542862],"about_ca_topic_score_codex":0.0000014819942,"about_ca_topic_score_gemma":2.0771091e-7,"teacher_disagreement_score":0.009102023,"about_ca_system_score_codex":0.000092604256,"about_ca_system_score_gemma":0.0001146251,"threshold_uncertainty_score":0.37855393},"labels":[],"label_agreement":null},{"id":"W4295922864","doi":"10.1016/j.ejmech.2022.114769","title":"Designed symmetrical β-hairpin peptides for treating multidrug-resistant salmonella typhimurium infections","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Key Research and Development Program of China; Priority Academic Program Development of Jiangsu Higher Education Institutions; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Salmonella; Antimicrobial; Proinflammatory cytokine; Microbiology; Multiple drug resistance; Chemistry; In vivo; Spleen; Salmonella enterica; Lytic cycle; Enterobacteriaceae; Antimicrobial peptides; Bacteria; Drug resistance; Inflammation; Biochemistry; Biology; Escherichia coli; Virology; Immunology; Gene","score_opus":0.013773857207944261,"score_gpt":0.2315128756969335,"score_spread":0.21773901848898922,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4295922864","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9862424,0.0024285857,0.0030569113,0.00056520145,0.00071492017,0.00014241421,0.00007615063,0.00004192112,0.006731488],"genre_scores_gemma":[0.99545854,0.00003967652,0.0005487642,0.00011737809,0.0003729496,0.000003948014,0.00003127852,0.000034237364,0.0033932063],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985603,0.00032040774,0.0005582675,0.00017623935,0.00009423406,0.00029056435],"domain_scores_gemma":[0.99875754,0.00041234214,0.000508718,0.00013487879,0.00012930983,0.000057211324],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011182018,0.000176881,0.0003421576,0.00010572182,0.0005435862,0.000016860411,0.0002907669,0.000038582322,0.0005295697],"category_scores_gemma":[0.0004400639,0.00015345098,0.00024835882,0.0001639604,0.00018200547,0.00006112063,0.00010787756,0.0006314939,0.000012963578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006569695,0.0002406201,0.0002018364,0.00006082495,0.00017695458,0.00012878576,0.00035176406,0.0001617153,0.97588366,0.000015005127,0.01927373,0.0028481102],"study_design_scores_gemma":[0.009501004,0.004166119,0.0019589865,0.00037761728,0.0005599704,0.006284142,0.012233339,0.00004848811,0.8238369,0.00006746383,0.14024249,0.00072344864],"about_ca_topic_score_codex":0.0000112983835,"about_ca_topic_score_gemma":3.6636632e-7,"teacher_disagreement_score":0.15204675,"about_ca_system_score_codex":0.00010687639,"about_ca_system_score_gemma":0.00010209295,"threshold_uncertainty_score":0.62575495},"labels":[],"label_agreement":null},{"id":"W4296690232","doi":"10.1016/j.ejmech.2022.114787","title":"Focusing on C-4 position of Hantzsch 1,4-dihydropyridines: Molecular modifications, enantioseparation, and binding mechanism to L- and T-type calcium channels","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Bilim Akademisi; Canada Research Chairs","keywords":"Chemistry; DHPS; Enantiomer; Moiety; Calcium channel; Stereochemistry; Voltage-dependent calcium channel; Selectivity; Combinatorial chemistry; L-type calcium channel; Calcium; Molecule; T-type calcium channel; Biochemistry; Organic chemistry","score_opus":0.01899307193153954,"score_gpt":0.24933763675722498,"score_spread":0.23034456482568544,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4296690232","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9968093,0.00037301678,0.0007861543,0.00071128306,0.00007197945,0.000033909328,0.000015529615,0.00000979279,0.0011890568],"genre_scores_gemma":[0.9989985,0.000051110306,0.00039414986,0.000100681085,0.00024729184,0.0000012832195,0.000011211522,0.000026309986,0.00016946482],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99865246,0.0000631216,0.00048675304,0.00020233021,0.00044269708,0.00015266462],"domain_scores_gemma":[0.9990698,0.00009131479,0.00036195017,0.00015120728,0.00013195424,0.00019377471],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00057818956,0.00014862724,0.00024879785,0.00006511194,0.00015516896,0.000034749126,0.00017140884,0.00002751712,0.00018701394],"category_scores_gemma":[0.00027249617,0.0001362692,0.000057943522,0.00014190744,0.0000517207,0.00006887491,0.00010763658,0.00031749252,0.0000011233014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014277888,0.00006322635,0.0000419806,0.00009800304,0.000035483543,0.000110470384,0.00022397863,0.00012662192,0.99779636,0.00006911155,0.00023275043,0.0010592415],"study_design_scores_gemma":[0.0004882021,0.00015362458,0.000033308992,0.0003221738,0.000064962216,0.0004972518,0.0004749691,0.00023437697,0.99618685,0.00008033457,0.0013263695,0.00013759983],"about_ca_topic_score_codex":0.0000027519438,"about_ca_topic_score_gemma":1.9078389e-8,"teacher_disagreement_score":0.0021892195,"about_ca_system_score_codex":0.00006587665,"about_ca_system_score_gemma":0.000035530797,"threshold_uncertainty_score":0.5556897},"labels":[],"label_agreement":null},{"id":"W4310017070","doi":"10.1016/j.ejmech.2022.114958","title":"Design and synthesis of new adamantyl derivatives as promising antiproliferative agents","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Higher Education Commision, Pakistan; University of Sharjah; Mitacs; Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Cell culture; Carbonic anhydrase; Cytotoxicity; Cytotoxic T cell; Enzyme; Cancer cell; Docking (animal); Stereochemistry; Biochemistry; Cancer; Pharmacology; In vitro; Biology","score_opus":0.020304504438887244,"score_gpt":0.24670797641442338,"score_spread":0.22640347197553615,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4310017070","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98736995,0.00096019247,0.007532684,0.0003022954,0.00007747776,0.000057147412,0.0000026547918,0.0000029660744,0.00369462],"genre_scores_gemma":[0.9974046,0.00014216146,0.0012803897,0.00019486075,0.00030974625,8.47352e-7,0.0000052320815,0.000015285761,0.0006469296],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990035,0.00024306499,0.00030236892,0.00012452134,0.00023583154,0.00009071276],"domain_scores_gemma":[0.9993475,0.000025849717,0.00034465603,0.00008817441,0.000085341446,0.00010849932],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00073826645,0.000095308926,0.000146109,0.000026798698,0.00008537902,0.000007907913,0.00011823463,0.000017508173,0.0002426816],"category_scores_gemma":[0.00033866154,0.000084752646,0.000050510433,0.000056089986,0.00007189736,0.0000061324026,0.00007743054,0.00017165503,6.343899e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000506957,0.000058715974,0.00014134447,0.00002889206,0.000064660904,0.00006266092,0.00029586122,0.00012315686,0.9862078,0.000001360766,0.009654146,0.0028544397],"study_design_scores_gemma":[0.00091186236,0.00078722293,0.00034030972,0.00009724273,0.000038284576,0.0007487559,0.0009831224,0.000026743262,0.98916584,0.0000118059115,0.0068035945,0.000085210544],"about_ca_topic_score_codex":7.415278e-7,"about_ca_topic_score_gemma":1.722989e-8,"teacher_disagreement_score":0.010034585,"about_ca_system_score_codex":0.000012953615,"about_ca_system_score_gemma":0.00012521693,"threshold_uncertainty_score":0.34561124},"labels":[],"label_agreement":null},{"id":"W4310733907","doi":"10.1016/j.ejmech.2022.114989","title":"Protease-activated receptor 2 (PAR2)-targeting peptide derivatives for positron emission tomography (PET) imaging","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Chemistry; In vivo; Biodistribution; DOTA; Imaging agent; Peptide; Preclinical imaging; Receptor; Ex vivo; Positron emission tomography; Spect imaging; In vitro; EC50; Chelation; Biochemistry; Nuclear medicine; Medicine","score_opus":0.016399846403549315,"score_gpt":0.25588174507839345,"score_spread":0.23948189867484415,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4310733907","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9886153,0.0010343663,0.0027839202,0.003142326,0.00032635176,0.00035078052,0.000012566932,0.000062224695,0.0036721868],"genre_scores_gemma":[0.9907501,0.000020635685,0.007336794,0.000506012,0.0008097854,0.000009463322,0.00005638481,0.00006267161,0.00044819448],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978998,0.00024053424,0.00068641204,0.00023352433,0.00066353276,0.00027623744],"domain_scores_gemma":[0.99839926,0.00008179226,0.0007249506,0.00016908783,0.00029083676,0.00033404777],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0016540794,0.00020758563,0.0003877604,0.000097677344,0.00031309156,0.00002278299,0.00023588793,0.000014767335,0.0008313557],"category_scores_gemma":[0.00042172283,0.00017902776,0.000254097,0.00026301804,0.00006423228,0.000105195795,0.00009297797,0.00068223645,0.0000019410122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00089388376,0.00020310341,0.001330343,0.00018136947,0.00012586551,0.0002774703,0.00042289819,0.000013599322,0.98402864,0.000004148235,0.010254282,0.002264402],"study_design_scores_gemma":[0.005658941,0.0011144449,0.001687924,0.0008277283,0.0002871675,0.0022114774,0.0049487306,0.00021798004,0.93815386,0.0000539865,0.04454974,0.00028800307],"about_ca_topic_score_codex":9.16556e-7,"about_ca_topic_score_gemma":6.3831465e-9,"teacher_disagreement_score":0.045874756,"about_ca_system_score_codex":0.00011327147,"about_ca_system_score_gemma":0.00014447853,"threshold_uncertainty_score":0.9102762},"labels":[],"label_agreement":null},{"id":"W4313530451","doi":"10.1016/j.ejmech.2022.115043","title":"Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Division of Chemistry; Genentech; National Institutes of Health; Ontario Genomics; Genome Canada; McGill University; National Institute of Allergy and Infectious Diseases; Bayer; Ontario Genomics Institute; National Sleep Foundation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Bristol-Myers Squibb; Pfizer; National Science Foundation","keywords":"Pharmacophore; Plasmodium falciparum; Chemistry; Pharmacology; Artemisinin; IC50; Drug discovery; Drug; EC50; Malaria; Plasmodium berghei; Antimalarial Agent; In vitro; Stereochemistry; Biochemistry; Immunology; Medicine","score_opus":0.012157192324976467,"score_gpt":0.24579220775232874,"score_spread":0.23363501542735227,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4313530451","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9871223,0.001357344,0.00006869077,0.0041032955,0.00025839484,0.00029566773,0.000021147313,0.000013187606,0.006759963],"genre_scores_gemma":[0.9955575,0.00003386886,0.00015436059,0.00018886675,0.0014616738,0.0000069932053,0.000013740012,0.000046614612,0.0025363876],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9969001,0.00023884376,0.00070352753,0.00021977395,0.0015798197,0.0003579342],"domain_scores_gemma":[0.99835265,0.000036210145,0.0005733572,0.00025778246,0.0003609384,0.00041903838],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013761516,0.00022034511,0.00049477944,0.00011697235,0.0001590121,0.000015596868,0.00033236694,0.000024954017,0.00053942075],"category_scores_gemma":[0.00027352263,0.00015626634,0.00017341488,0.0003257591,0.00018478201,0.00010398692,0.00023143558,0.0012869624,0.0000034862005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.014905607,0.00065159064,0.00030407205,0.0004204445,0.00028927872,0.00863933,0.00033045385,0.000049703973,0.96156234,0.000005416391,0.009795216,0.003046535],"study_design_scores_gemma":[0.019492347,0.014550845,0.0014750833,0.001661254,0.0004873443,0.00568208,0.0026375027,0.00009488584,0.9275525,0.000008797482,0.02600779,0.00034957472],"about_ca_topic_score_codex":0.00000517924,"about_ca_topic_score_gemma":1.4546107e-7,"teacher_disagreement_score":0.034009855,"about_ca_system_score_codex":0.00015507478,"about_ca_system_score_gemma":0.00076018384,"threshold_uncertainty_score":0.6372356},"labels":[],"label_agreement":null},{"id":"W4317685215","doi":"10.1016/j.ejmech.2023.115131","title":"Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo","year":2023,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Beef Cattle Research Council; Ministry of Science and Technology, Taiwan; Academia Sinica; Ministry of Education","keywords":"Peptide; Chemistry; Antimicrobial peptides; Antimicrobial; Vibrio vulnificus; In vivo; In vitro; Cytotoxicity; Combinatorial chemistry; Cationic polymerization; Rational design; Antibacterial activity; Structure–activity relationship; Biochemistry; Microbiology; Bacteria; Nanotechnology; Biology; Organic chemistry","score_opus":0.015028913838988902,"score_gpt":0.23082212060657792,"score_spread":0.215793206767589,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4317685215","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9986929,0.00015651461,0.000012455555,0.0001811742,0.00040743544,0.000051950752,0.000024821476,0.000010083072,0.0004626465],"genre_scores_gemma":[0.9994053,0.00019572992,0.00002857181,0.000018804278,0.00014879354,1.9763588e-7,0.000018925335,0.000014999487,0.00016867],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988272,0.00020739893,0.00050059205,0.00016359417,0.000061851075,0.0002393621],"domain_scores_gemma":[0.9993554,0.000054891305,0.00040179244,0.00009330634,0.000066342334,0.000028310043],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006634517,0.00015468147,0.00039013466,0.00014329438,0.000038730912,0.000015094475,0.00017424312,0.000074032716,0.00005393058],"category_scores_gemma":[0.00005511912,0.00013753229,0.000078964105,0.00014653924,0.00035932113,0.00013317882,0.00005803596,0.00051982654,0.0000052367873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017627283,0.000084686595,0.00028177648,0.00014769536,0.000036640322,0.0002506927,0.00024177872,0.000044127606,0.99617714,0.0000016734351,0.00026398763,0.00070705736],"study_design_scores_gemma":[0.0025092706,0.000078107085,0.0127169,0.0003531034,0.00002076323,0.00039131302,0.0008625407,0.000036681824,0.98285466,0.000007819229,0.000043341635,0.00012552444],"about_ca_topic_score_codex":0.000031524378,"about_ca_topic_score_gemma":0.0000021267788,"teacher_disagreement_score":0.01332252,"about_ca_system_score_codex":0.000028809232,"about_ca_system_score_gemma":0.00008077036,"threshold_uncertainty_score":0.5608404},"labels":[],"label_agreement":null},{"id":"W4321487052","doi":"10.1016/j.ejmech.2023.115222","title":"Investigating a new C2-symmetric testosterone dimer and its dihydrotestosterone analog: Synthesis, antiproliferative activity on prostate cancer cell lines and interaction with CYP3A4","year":2023,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; Université du Québec à Trois-Rivières","keywords":"LNCaP; Dihydrotestosterone; Chemistry; Dimer; Androgen; Cyproterone acetate; Stereochemistry; Antiandrogen; IC50; Testosterone (patch); Prostate cancer; Endocrinology; Biochemistry; Internal medicine; Hormone; Cancer; Biology; In vitro","score_opus":0.034041800067827144,"score_gpt":0.2845809382263193,"score_spread":0.25053913815849216,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4321487052","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9929265,0.0015827784,0.00003219206,0.0011343765,0.00007876138,0.00007128473,0.000019808615,0.000060055907,0.004094261],"genre_scores_gemma":[0.99634176,0.00082097296,0.0005661563,0.00006818996,0.00091199233,0.0000045850593,0.000004257667,0.000087351735,0.0011947522],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99784875,0.00016672704,0.00057478074,0.00046272756,0.0005859111,0.00036108244],"domain_scores_gemma":[0.9973023,0.000872922,0.0008805048,0.00024889325,0.0001645795,0.00053080276],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0010106543,0.00041204126,0.0005497673,0.00008434625,0.000132991,0.00007159673,0.00024113445,0.00008504809,0.0002810603],"category_scores_gemma":[0.0017838986,0.00032147873,0.00005530104,0.00039581422,0.00017905745,0.00022538222,0.00014076603,0.00088668516,0.000005551765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00030059053,0.00006858333,0.0022047935,0.00064134866,0.000116703806,0.00026069404,0.00088844914,0.000023727267,0.97005695,2.0333715e-7,0.0002877426,0.02515023],"study_design_scores_gemma":[0.001554229,0.00021549997,0.00222629,0.0023149156,0.00022582333,0.0010260165,0.00091274886,0.0004077898,0.99043226,0.000004881447,0.00036231248,0.0003172253],"about_ca_topic_score_codex":0.000019629551,"about_ca_topic_score_gemma":0.0000016354223,"teacher_disagreement_score":0.024833005,"about_ca_system_score_codex":0.00013225316,"about_ca_system_score_gemma":0.00018815165,"threshold_uncertainty_score":0.9999237},"labels":[],"label_agreement":null},{"id":"W4322011930","doi":"10.1016/j.ejmech.2023.115231","title":"Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor","year":2023,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Genentech; Vlaamse regering; Innovative Medicines Initiative; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; McGill University; Innovative Health Initiative; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Bayer; Pfizer","keywords":"Chemistry; Kinase; Vemurafenib; Protein kinase domain; MAPK/ERK pathway; Protein kinase A; V600E; Moiety; Allosteric regulation; Mutant; Stereochemistry; Cell biology; Biochemistry; Enzyme; Cancer research; Biology","score_opus":0.02658339831722194,"score_gpt":0.23327497006591655,"score_spread":0.2066915717486946,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4322011930","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99712265,0.00034972408,0.0011863809,0.00018055024,0.0001504057,0.00003657372,0.0000068220306,0.0000056494487,0.00096125924],"genre_scores_gemma":[0.9980719,0.00025597372,0.0005544587,0.00004890979,0.000733747,6.447609e-7,0.000013608424,0.00002017289,0.0003005729],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9991324,0.00006979421,0.0003515895,0.00013096424,0.00018888921,0.00012636611],"domain_scores_gemma":[0.9992705,0.000032666987,0.0003069406,0.0001386494,0.000138808,0.00011244302],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008629126,0.000110579174,0.00018090235,0.000034362452,0.000042514577,0.0000064323804,0.00013510806,0.00004805539,0.000032161945],"category_scores_gemma":[0.00038881783,0.000091475595,0.000052426563,0.00008837988,0.00007444598,0.000004894219,0.00007640216,0.00011522461,0.0000035637156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024483167,0.000042536514,0.00017154173,0.000066665874,0.00004491503,0.000066838285,0.0001312632,0.0000074353275,0.99333537,6.669575e-7,0.0021778222,0.003710105],"study_design_scores_gemma":[0.0007892767,0.0005357457,0.004938571,0.00018761506,0.000052879674,0.0005327896,0.00014297865,0.000036778336,0.9863141,0.0000025505478,0.0063586333,0.0001080815],"about_ca_topic_score_codex":4.5774271e-7,"about_ca_topic_score_gemma":3.8608142e-8,"teacher_disagreement_score":0.0070212777,"about_ca_system_score_codex":0.0000059473873,"about_ca_system_score_gemma":0.00006878899,"threshold_uncertainty_score":0.37302664},"labels":[],"label_agreement":null},{"id":"W4375859126","doi":"10.1016/j.ejmech.2023.115471","title":"Molecular-level strategic goals and repressors in Leishmaniasis – Integrated data to accelerate target-based heterocyclic scaffolds","year":2023,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Ministry of Rural Affairs; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Chemistry; Biochemistry; Polyamine; Enzyme; Topoisomerase; Leishmaniasis; Pharmacology; Biology; Genetics","score_opus":0.32732951902474955,"score_gpt":0.4156708143312008,"score_spread":0.08834129530645124,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4375859126","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.015368762,0.9794425,0.00005734293,0.0009795476,0.00017327323,0.0007302286,0.00019806184,0.000059580005,0.0029907078],"genre_scores_gemma":[0.0073794206,0.98947346,0.0010719603,0.000269647,0.00072117685,0.000015785958,0.0003082234,0.0002855033,0.00047484384],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9932205,0.0009508073,0.0025362573,0.0010290373,0.001494543,0.0007688329],"domain_scores_gemma":[0.9954588,0.00043573062,0.0012251859,0.0014444803,0.00046839786,0.000967409],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0045836368,0.0008393567,0.0034559807,0.00067651254,0.000082261,0.00013593817,0.0017405372,0.00020683622,0.00012315963],"category_scores_gemma":[0.0025861994,0.00061770895,0.0004015501,0.0012015636,0.00027405925,0.0001452704,0.00087623845,0.001872875,0.000066878936],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018824207,0.0010803377,0.0005206586,0.13908191,0.005585567,0.15770788,0.0004770888,0.00008140873,0.01210476,0.0000053660483,0.030299282,0.6511733],"study_design_scores_gemma":[0.008321993,0.0019074199,0.001018935,0.26041663,0.0040422734,0.006717902,0.00146007,0.00017450366,0.0025275084,0.000018634553,0.71150666,0.001887455],"about_ca_topic_score_codex":0.000018695586,"about_ca_topic_score_gemma":0.000004737922,"teacher_disagreement_score":0.6812074,"about_ca_system_score_codex":0.00033779195,"about_ca_system_score_gemma":0.00090042443,"threshold_uncertainty_score":0.9996274},"labels":[],"label_agreement":null},{"id":"W4384927191","doi":"10.1016/j.ejmech.2023.115671","title":"Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry","year":2023,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Brock University","funders":"","keywords":"Chemistry; Druggability; EGFR inhibitors; Erlotinib; Biochemistry; Lysine; Drug discovery; Covalent bond; Target protein; Kinase; Cell growth; Epidermal growth factor receptor; Combinatorial chemistry; Receptor; Amino acid","score_opus":0.023093395398547465,"score_gpt":0.24250509938056974,"score_spread":0.21941170398202228,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4384927191","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9787852,0.0007729352,0.0002667655,0.00065075763,0.00007748614,0.00006660491,0.0001705825,0.00006265392,0.019146994],"genre_scores_gemma":[0.9963567,0.00009127045,0.00015983898,0.00005597118,0.00067867356,0.0000033566475,0.00018149856,0.00007531738,0.0023973684],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9972479,0.000064388245,0.0009316479,0.00038845566,0.0008972408,0.00047036968],"domain_scores_gemma":[0.9971308,0.00030591438,0.0013205439,0.0005520974,0.00035989596,0.0003307354],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00094488444,0.0003975044,0.0005222417,0.00003944303,0.00024667146,0.000034960878,0.00093252107,0.00011977559,0.0010075114],"category_scores_gemma":[0.00027293622,0.00032452293,0.00033900124,0.0006281918,0.00044337034,0.00010535142,0.0001452842,0.0009867501,0.00001603304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018343753,0.00020728249,0.0004457801,0.0008355325,0.00011707164,0.00013704301,0.00019335916,0.0005904076,0.9760604,2.5790263e-7,0.020880602,0.00034885446],"study_design_scores_gemma":[0.0018025809,0.000027533055,0.00008983375,0.0004151213,0.00022306382,0.00023139322,0.0016679827,0.00054480653,0.9822444,0.0000123442405,0.0124518555,0.00028912004],"about_ca_topic_score_codex":0.000010974475,"about_ca_topic_score_gemma":5.5226316e-8,"teacher_disagreement_score":0.017571485,"about_ca_system_score_codex":0.0002632662,"about_ca_system_score_gemma":0.00037672333,"threshold_uncertainty_score":0.99992067},"labels":[],"label_agreement":null},{"id":"W4385739754","doi":"10.1016/j.ejmech.2023.115713","title":"Development of selective class I protein arginine methyltransferase inhibitors through fragment-based drug design approach","year":2023,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Methyltransferase; Chemistry; Biochemistry; Quinazoline; Drug discovery; Methylation; Arginine; Drug development; Small molecule; Drug design; Rational design; Enzyme; Computational biology; Drug; Pharmacology; Stereochemistry; DNA; Biology; Amino acid; Genetics","score_opus":0.017686596588819707,"score_gpt":0.24246396193535272,"score_spread":0.224777365346533,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385739754","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.933025,0.0007073759,0.06367179,0.00023495537,0.00011251391,0.00021072266,0.000004724635,0.000014658712,0.0020182452],"genre_scores_gemma":[0.97695696,0.000035484896,0.021975202,0.000035664656,0.0005634504,0.0000061895576,0.00006848618,0.00004455322,0.0003139907],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99810106,0.00023500557,0.0007057361,0.00024590138,0.00048427455,0.00022800578],"domain_scores_gemma":[0.9989718,0.000022077907,0.00043483873,0.00018903408,0.00025697207,0.0001252819],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015446496,0.00020405528,0.00026515016,0.00006092349,0.000064099186,0.00000797253,0.00024573586,0.00007223755,0.000020404277],"category_scores_gemma":[0.00013441482,0.00018113747,0.0001275547,0.0003116925,0.00011230369,0.0000073193496,0.00003725341,0.00030483518,0.0000038309404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00048051254,0.000087591965,0.000017740014,0.00014685947,0.00016138141,0.000031232277,0.0005630292,0.004817693,0.9871321,0.0000011421977,0.0032698102,0.0032909366],"study_design_scores_gemma":[0.0017975572,0.00021667176,0.0001508702,0.00024713427,0.000054307406,0.00004752933,0.00045211986,0.00017254098,0.9877413,0.0000064146466,0.008944524,0.00016902765],"about_ca_topic_score_codex":9.136385e-7,"about_ca_topic_score_gemma":2.8276742e-7,"teacher_disagreement_score":0.04393197,"about_ca_system_score_codex":0.000068645844,"about_ca_system_score_gemma":0.0005208983,"threshold_uncertainty_score":0.7386572},"labels":[],"label_agreement":null},{"id":"W4388196799","doi":"10.1016/j.ejmech.2023.115886","title":"From garden to lab: C-3 chemical modifications of tomatidine unveil broad-spectrum ATP synthase inhibitors to combat bacterial resistance","year":2023,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Bacteria; Context (archaeology); Antibiotic resistance; ATP synthase; Mode of action; Microbiology; Antibiotics; Biology; Gram-negative bacteria; Chemistry; Biochemistry; Enzyme; Escherichia coli; Gene; Genetics","score_opus":0.01667557864531022,"score_gpt":0.27878750302667055,"score_spread":0.26211192438136033,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4388196799","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99376565,0.00024640263,0.00040362115,0.0029161132,0.00017495766,0.000095634,0.00013251371,0.000015051411,0.0022500774],"genre_scores_gemma":[0.9953449,0.000077742494,0.00054476457,0.00011133681,0.0026043134,0.0000030707354,0.0001161009,0.00004429013,0.0011535008],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9980502,0.00012800324,0.0006646133,0.00030519452,0.00054000923,0.0003119703],"domain_scores_gemma":[0.9985353,0.000066691326,0.00025033116,0.00043530995,0.00021451901,0.0004979017],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00069014676,0.00019143453,0.00031835813,0.000074224285,0.000055274395,0.000022462598,0.0005945158,0.000067408815,0.0002048046],"category_scores_gemma":[0.00090285414,0.00017340883,0.00014847517,0.00030325574,0.00011413235,0.0000064184537,0.0002506217,0.00024574305,0.00006405191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006365055,0.00007176289,0.000048048318,0.000050779156,0.00007418192,0.00017065315,0.00024015707,0.000031351152,0.94149816,8.533202e-7,0.05628603,0.0008915228],"study_design_scores_gemma":[0.000860831,0.00022971265,0.00041518343,0.00031805917,0.000032374348,0.000020397583,0.00057379965,0.000008874646,0.9537955,0.0000062297577,0.0435738,0.00016522325],"about_ca_topic_score_codex":0.000006228962,"about_ca_topic_score_gemma":0.0000018866688,"teacher_disagreement_score":0.012712229,"about_ca_system_score_codex":0.000038267273,"about_ca_system_score_gemma":0.0001492269,"threshold_uncertainty_score":0.7071407},"labels":[],"label_agreement":null},{"id":"W4389118716","doi":"10.1016/j.ejmech.2023.115971","title":"Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens","year":2023,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Dihydrofolate reductase; Chemistry; Cancer cell; Antifolate; Pharmacology; In vitro; Methotrexate; Pyrimethamine; Cancer; Biochemistry; Enzyme; Plasmodium falciparum; Biology; Antimetabolite; Immunology","score_opus":0.035933770856187756,"score_gpt":0.3098429906167441,"score_spread":0.2739092197605563,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389118716","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99321496,0.0028951766,0.0011815648,0.0012675823,0.000087133994,0.000049315382,0.000021763959,0.000008453375,0.0012740295],"genre_scores_gemma":[0.997011,0.0010670972,0.0003517854,0.0002609548,0.0010327027,0.0000014659033,0.00007478155,0.000029883804,0.00017032122],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983809,0.0002316047,0.0005068825,0.00023156546,0.0003458521,0.00030322265],"domain_scores_gemma":[0.99896675,0.00003777908,0.00033764172,0.0002796932,0.00025606123,0.0001220875],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011076395,0.00016711936,0.00026908476,0.000028595503,0.00006381206,0.000009971019,0.00060331397,0.000093354174,0.00003185978],"category_scores_gemma":[0.0006837963,0.000110654306,0.00020135677,0.00021312908,0.0006251616,0.0000056250265,0.00028459018,0.00051896716,0.0000038565495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00005439795,0.000035360892,0.0003120022,0.00007528065,0.00013987804,0.000046008285,0.0000906576,0.0000423253,0.99307543,0.000004317742,0.0029034682,0.0032208832],"study_design_scores_gemma":[0.00072675716,0.00016314955,0.00034189987,0.000096225915,0.000050250008,0.00016020203,0.00016077822,0.000089369234,0.9930037,0.00010611082,0.0049857846,0.00011576868],"about_ca_topic_score_codex":0.0000058664687,"about_ca_topic_score_gemma":1.4060231e-7,"teacher_disagreement_score":0.0037960273,"about_ca_system_score_codex":0.000010247512,"about_ca_system_score_gemma":0.00012106337,"threshold_uncertainty_score":0.45123518},"labels":[],"label_agreement":null},{"id":"W4390966290","doi":"10.1016/j.ejmech.2024.116157","title":"Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Danmarks Frie Forskningsfond; China Scholarship Council; Københavns Universitet; Forskerakademiet; Strategic Science Fund","keywords":"Chemistry; Metabotropic glutamate receptor; Agonist; Metabotropic receptor; Glutamate receptor; Metabotropic glutamate receptor 1; Stereochemistry; Cyclopropane; Glutamic acid; Quisqualic acid; Receptor; Metabotropic glutamate receptor 2; Biochemistry; Amino acid; AMPA receptor; Ring (chemistry)","score_opus":0.022563432613664173,"score_gpt":0.2941783075175968,"score_spread":0.27161487490393266,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4390966290","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9973002,0.00042002703,0.000044954533,0.00095470925,0.0003347279,0.00011110564,0.000023535682,0.000027769182,0.000782955],"genre_scores_gemma":[0.9962858,0.0028901105,0.000026339932,0.00031286263,0.00029593048,0.0000020797747,0.0000012693298,0.000019406769,0.00016619514],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99780726,0.00049016223,0.000568748,0.00031905135,0.00055971614,0.00025502904],"domain_scores_gemma":[0.998763,0.00041480898,0.0003241308,0.00008193447,0.00016697418,0.00024910193],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005800832,0.00018844637,0.00032322155,0.00017167811,0.00012932137,0.00007400204,0.00030733764,0.000042237396,0.00013499429],"category_scores_gemma":[0.0013459536,0.00014044931,0.00005999052,0.0004974888,0.00059213344,0.00031093202,0.000104961066,0.00059203146,0.0000087067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00036025708,0.000042507487,0.000109224326,0.00015776425,0.000030205023,0.001079303,0.00015765787,9.521157e-7,0.99092007,0.000012992323,0.000092464485,0.0070366194],"study_design_scores_gemma":[0.00055061094,0.0004990105,0.0056560975,0.00014842297,0.00012130027,0.0024532655,0.000031109852,0.000308772,0.98880506,0.000015651563,0.0012984144,0.000112301845],"about_ca_topic_score_codex":8.576337e-7,"about_ca_topic_score_gemma":2.0030146e-8,"teacher_disagreement_score":0.006924317,"about_ca_system_score_codex":0.00003017395,"about_ca_system_score_gemma":0.00018530487,"threshold_uncertainty_score":0.57273567},"labels":[],"label_agreement":null},{"id":"W4391772853","doi":"10.1016/j.ejmech.2024.116238","title":"Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Fibroblast activation protein, alpha; Quinoline; Cancer imaging; Cancer therapy; Cancer research; Profiling (computer programming); Radiochemistry; Pharmacology; Cancer; Internal medicine; Organic chemistry","score_opus":0.037375330267592884,"score_gpt":0.3351168804384025,"score_spread":0.2977415501708096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4391772853","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9849385,0.008875229,0.004609659,0.0010560823,0.00002021694,0.0003887057,0.000010545659,0.000012246,0.000088839035],"genre_scores_gemma":[0.9948093,0.00015592645,0.0044848965,0.00008166524,0.00036899367,0.0000099403005,0.000025949537,0.000028725004,0.0000345612],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9983957,0.00008852223,0.0007525096,0.00019494281,0.00044603136,0.00012228804],"domain_scores_gemma":[0.99870086,0.00021509497,0.00045742828,0.00008608735,0.00041559248,0.00012491555],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014254391,0.00014996073,0.00034004555,0.00013716405,0.00004898288,0.000015254221,0.000060321272,0.000039769035,0.00010774578],"category_scores_gemma":[0.0006160469,0.00011643425,0.00010197556,0.0001671428,0.00010916964,0.00008982554,0.000013604276,0.00025472898,1.8527892e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015736836,0.00009988426,0.0006777293,0.002819665,0.00020990294,0.000026950273,0.00040773154,0.00006758948,0.9486568,8.6723134e-7,0.00008523308,0.045373984],"study_design_scores_gemma":[0.004137728,0.000459416,0.0028623901,0.021068154,0.00022151883,0.00009311019,0.00019723525,0.018667806,0.9517275,0.0000058099668,0.00045080975,0.00010853627],"about_ca_topic_score_codex":7.260985e-7,"about_ca_topic_score_gemma":1.00668956e-7,"teacher_disagreement_score":0.045265447,"about_ca_system_score_codex":0.000060504666,"about_ca_system_score_gemma":0.00044184693,"threshold_uncertainty_score":0.4748051},"labels":[],"label_agreement":null},{"id":"W4393952511","doi":"10.1016/j.ejmech.2024.116357","title":"Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Division of Chemistry; National Institute of Diabetes and Digestive and Kidney Diseases; Engineering and Physical Sciences Research Council; University of North Carolina at Chapel Hill; National Institutes of Health; Biocenter Finland; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novartis Pharma; China Scholarship Council; Pfizer; National Science Foundation","keywords":"Kinome; Oxindole; Chemistry; Computational biology; Drug discovery; Kinase; Structure–activity relationship; Allosteric regulation; Lead compound; Quantitative structure–activity relationship; Small molecule; Combinatorial chemistry; Stereochemistry; Biochemistry; Enzyme; Biology; In vitro","score_opus":0.017824963098592446,"score_gpt":0.25369984147126734,"score_spread":0.2358748783726749,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4393952511","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9673986,0.0046970756,0.027392015,0.000100420126,0.0001169172,0.000049040125,0.00002002222,0.0000033541132,0.00022254161],"genre_scores_gemma":[0.9963673,0.00006997967,0.0031876042,0.000007924049,0.00028314887,1.1659464e-7,0.000015130644,0.000019445351,0.000049360504],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99899125,0.00017357561,0.00038533844,0.00014558608,0.00021569077,0.00008858219],"domain_scores_gemma":[0.9992848,0.000032957265,0.00038107656,0.0001093001,0.000121207726,0.00007066827],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00057164946,0.00011865891,0.00018436507,0.000060673643,0.000042732747,0.000018905987,0.00008199502,0.000056456167,0.000018748407],"category_scores_gemma":[0.00023288716,0.00010105438,0.00008475751,0.00012339967,0.00014526081,0.000025529072,0.00004065104,0.00024085889,8.223067e-8],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00021465622,0.000022205619,0.00018939209,0.0002772861,0.00006293029,0.000058237467,0.00017175086,0.013519138,0.985056,0.000015680327,0.00006883679,0.00034388472],"study_design_scores_gemma":[0.000522666,0.0002526721,0.0004170254,0.0006527597,0.000092959315,0.00024990566,0.0003214347,0.0033329448,0.99386066,0.000046611145,0.00013866651,0.00011170072],"about_ca_topic_score_codex":0.0000017952824,"about_ca_topic_score_gemma":3.78289e-7,"teacher_disagreement_score":0.028968677,"about_ca_system_score_codex":0.00001869933,"about_ca_system_score_gemma":0.00012264687,"threshold_uncertainty_score":0.4120878},"labels":[],"label_agreement":null},{"id":"W4398768432","doi":"10.1016/j.ejmech.2024.116533","title":"Design, synthesis and antiproliferative activity of raloxifene/histone deacetylase inhibitor hybrids in breast cancer","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Raloxifene; Chemistry; Histone deacetylase; Histone deacetylase inhibitor; Breast cancer; Cancer research; Tamoxifen; Pharmacology; Histone; Cancer; Internal medicine; Biochemistry; Gene","score_opus":0.013789920669580326,"score_gpt":0.29125233065277273,"score_spread":0.2774624099831924,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4398768432","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9910011,0.0066407924,0.0009513761,0.00066734164,0.00013838297,0.00007858205,0.000036876223,0.000005615686,0.0004798885],"genre_scores_gemma":[0.997506,0.0011339486,0.00025229692,0.000027329717,0.0008198478,0.0000037006273,0.0000025555457,0.000042077594,0.00021224233],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99822176,0.0003722077,0.00047947516,0.00028868343,0.00039876794,0.00023912007],"domain_scores_gemma":[0.99913144,0.000092458286,0.00019392245,0.00018150276,0.00019167953,0.00020897831],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015594175,0.0002011265,0.00033677174,0.0001099764,0.00003847663,0.00002154634,0.00021219725,0.00006722245,0.000060701554],"category_scores_gemma":[0.00029570647,0.00017132505,0.00010041163,0.00017540634,0.00032894252,0.000016603328,0.00009514351,0.00047864177,0.0000023821624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0007630484,0.00009246983,0.00022123092,0.00031444055,0.00008886329,0.0008342866,0.00017987925,0.00004537615,0.9840772,3.5772206e-7,0.0029731942,0.01040963],"study_design_scores_gemma":[0.00068994425,0.0002021612,0.001094718,0.00096396374,0.000045708315,0.0014224513,0.000093337905,0.00012269287,0.9944139,0.0000016432582,0.0007963184,0.00015317822],"about_ca_topic_score_codex":0.000013050985,"about_ca_topic_score_gemma":0.0000015268,"teacher_disagreement_score":0.01033666,"about_ca_system_score_codex":0.000091966336,"about_ca_system_score_gemma":0.0004068449,"threshold_uncertainty_score":0.69864327},"labels":[],"label_agreement":null},{"id":"W4400623974","doi":"10.1016/j.ejmech.2024.116672","title":"Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Structural Genomics Consortium; Genentech; Innovative Medicines Initiative; Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; McGill University; Innovative Health Initiative; Ontario Genomics; Genome Canada; Diamond Light Source; Bayer; Pfizer; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Chemistry; Moiety; Casein kinase 2; Allosteric regulation; Kinase; Stereochemistry; Serine; Binding site; Small molecule; Threonine; Biochemistry; Casein kinase 1; Combinatorial chemistry; Chemical biology; Protein kinase A; Enzyme; Cyclin-dependent kinase 2","score_opus":0.016219074664118243,"score_gpt":0.2727558761429992,"score_spread":0.2565368014788809,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400623974","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9836514,0.010806759,0.0037867038,0.00024559206,0.0000860551,0.00009119078,0.00000976835,0.0000054075444,0.0013171203],"genre_scores_gemma":[0.9975536,0.000079921265,0.0013198764,0.000022503009,0.0009618056,0.0000027091955,0.000014111412,0.000019694713,0.000025788559],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99898845,0.000110210734,0.00035852473,0.00015173413,0.00028873567,0.00010232135],"domain_scores_gemma":[0.99916416,0.000056427325,0.00018956122,0.00007301083,0.00043216112,0.00008467565],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0023716001,0.00009842852,0.00014891046,0.000031459796,0.000024891753,0.00001405535,0.000093588555,0.00004491942,0.000019772197],"category_scores_gemma":[0.0010289146,0.00008286045,0.00009587026,0.000060506012,0.00007386366,0.000005705489,0.000028489498,0.00012234761,4.0577183e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00011179956,0.000015996042,0.000017549934,0.00020677336,0.00008398713,0.000010835852,0.00007148531,0.00004147545,0.97841734,0.000007084664,0.0009112079,0.020104488],"study_design_scores_gemma":[0.0005193899,0.00012266662,0.00005665561,0.00039680113,0.00019020055,0.00014267713,0.00011542895,0.001013373,0.99334913,0.000052853546,0.003957997,0.000082806546],"about_ca_topic_score_codex":3.244857e-7,"about_ca_topic_score_gemma":2.6955652e-8,"teacher_disagreement_score":0.02002168,"about_ca_system_score_codex":0.000023273718,"about_ca_system_score_gemma":0.00015701867,"threshold_uncertainty_score":0.33789513},"labels":[],"label_agreement":null},{"id":"W4400871417","doi":"10.1016/j.ejmech.2024.116692","title":"Candida antarctica Lipase B mediated kinetic resolution: A sustainable method for chiral synthesis of antiproliferative β-lactams","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Trinity College","funders":"Trinity College Dublin; Royal Society of Chemistry","keywords":"Chemistry; Kinetic resolution; Enantiomer; Substituent; Biocatalysis; Candida antarctica; Lactam; Stereochemistry; Enantiomeric excess; Enantioselective synthesis; Diastereomer; Substrate (aquarium); Racemic mixture; Lipase; Combinatorial chemistry; Organic chemistry; Catalysis; Enzyme; Reaction mechanism","score_opus":0.007885369477850939,"score_gpt":0.264925440759813,"score_spread":0.25704007128196205,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4400871417","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8103855,0.021138351,0.15384747,0.0018892715,0.0005113375,0.00047749426,0.00013391594,0.000030363422,0.0115863],"genre_scores_gemma":[0.99501187,0.00035350348,0.0024484168,0.00007290778,0.00092843,0.0000046270375,0.000082245184,0.000034868248,0.001063141],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986059,0.000172649,0.0005513098,0.00022026592,0.00023572764,0.00021415121],"domain_scores_gemma":[0.99885213,0.00012290051,0.0002676537,0.00018426964,0.000437778,0.00013525614],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014830687,0.00015647314,0.0002822741,0.00006100536,0.000053477983,0.000025226984,0.00020620602,0.00005811674,0.0000513542],"category_scores_gemma":[0.0015188205,0.00012340597,0.00019232629,0.0001757524,0.00010739263,0.000011630782,0.000050560913,0.000171809,0.0000011279743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00050464965,0.00006919117,0.00005559804,0.00070269493,0.00025740685,0.00016218057,0.0001870664,0.00009912205,0.98928994,0.00003454002,0.0072276164,0.0014099849],"study_design_scores_gemma":[0.00072149385,0.0006719411,0.00010773563,0.0003891255,0.00028272765,0.0003954477,0.0007617001,0.00090792147,0.955648,0.000021528509,0.039943233,0.0001491097],"about_ca_topic_score_codex":0.0000039401757,"about_ca_topic_score_gemma":4.1392968e-7,"teacher_disagreement_score":0.18462636,"about_ca_system_score_codex":0.00003412384,"about_ca_system_score_gemma":0.00023534245,"threshold_uncertainty_score":0.503235},"labels":[],"label_agreement":null},{"id":"W4401410514","doi":"10.1016/j.ejmech.2024.116704","title":"Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions","year":2024,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Small molecule; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Stereochemistry; Covalent bond; Molecule; Biological activity; Combinatorial chemistry; Coronavirus disease 2019 (COVID-19); Computational biology; Biochemistry; In vitro; Organic chemistry","score_opus":0.2044678315272578,"score_gpt":0.38727504226887977,"score_spread":0.18280721074162196,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4401410514","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.009388429,0.8209276,0.16801782,0.00021432145,0.0007420783,0.0001890844,0.000004536711,0.00003392987,0.00048219215],"genre_scores_gemma":[0.032409754,0.95369524,0.012867999,0.00003818241,0.00087745243,0.000006140578,0.000010139629,0.00006158238,0.00003349427],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99623245,0.0014571915,0.0012077363,0.0004751583,0.00043965605,0.00018783224],"domain_scores_gemma":[0.996999,0.0007935596,0.001447907,0.00035588312,0.00025556554,0.00014806555],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0023011162,0.0004145895,0.0010457814,0.00030665039,0.000080970894,0.00012360045,0.0011196,0.000092967835,0.000004216933],"category_scores_gemma":[0.0003584557,0.00027263907,0.000401248,0.0005887953,0.00022874233,0.00020428626,0.0005716936,0.0011864145,0.000009815214],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000021122718,0.00014319173,0.0000014406742,0.0056731896,0.00041195977,0.00049634866,0.00085185585,0.000010821491,0.059409697,0.00010411025,0.0010029097,0.9318734],"study_design_scores_gemma":[0.0014212484,0.0014208913,0.00008233576,0.08536048,0.002126713,0.011052522,0.000670734,0.0041551474,0.19430491,0.001530429,0.6958571,0.0020174577],"about_ca_topic_score_codex":0.0000014705421,"about_ca_topic_score_gemma":2.4229104e-7,"teacher_disagreement_score":0.9298559,"about_ca_system_score_codex":0.00019140063,"about_ca_system_score_gemma":0.0005978017,"threshold_uncertainty_score":0.9999726},"labels":[],"label_agreement":null},{"id":"W4402535937","doi":"10.1016/j.ejmech.2024.116870","title":"Tetrazoles: A multi-potent motif in drug design","year":2024,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis of Tetrazole Derivatives","field":"Chemistry","cited_by":75,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"China Scholarship Council; University of Queensland; Emory University","keywords":"Chemistry; Motif (music); Drug; Combinatorial chemistry; Drug discovery; Stereochemistry; Pharmacology; Computational biology; Biochemistry","score_opus":0.08575543959151338,"score_gpt":0.32443656337393617,"score_spread":0.2386811237824228,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402535937","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00011207418,0.9889966,0.00025766745,0.0000739538,0.00035452747,0.00010919704,0.000027614155,0.00006467078,0.010003695],"genre_scores_gemma":[0.00087753375,0.99299294,0.001972787,0.00002334749,0.0018956207,0.000006973389,0.000017117423,0.00029134698,0.0019223234],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99459565,0.00042034985,0.0027342332,0.0006339357,0.0010268608,0.0005889979],"domain_scores_gemma":[0.996412,0.00062278536,0.0017042881,0.00065734435,0.00014421069,0.0004593852],"candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0027997405,0.0009890276,0.0025885776,0.00032834083,0.000048851587,0.00010236855,0.0019381385,0.00022569613,0.00068204815],"category_scores_gemma":[0.0013959641,0.00073406496,0.0011190734,0.00040706777,0.00027055253,0.00011986852,0.00025007117,0.0035766684,0.00019934951],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000047905498,0.0003301251,0.0000040919513,0.06474556,0.0008265588,0.020619206,0.0006452101,0.000012210572,0.0018642436,7.42427e-7,0.0087669175,0.9021372],"study_design_scores_gemma":[0.0009789793,0.000033748478,0.000003320194,0.168131,0.0020502377,0.005016352,0.0008924763,0.000021468999,0.004194062,0.00000685141,0.81785995,0.0008115756],"about_ca_topic_score_codex":0.0000024877822,"about_ca_topic_score_gemma":2.7650702e-7,"teacher_disagreement_score":0.90132564,"about_ca_system_score_codex":0.0005282902,"about_ca_system_score_gemma":0.00064404216,"threshold_uncertainty_score":0.99951106},"labels":[],"label_agreement":null},{"id":"W4402892953","doi":"10.1016/j.ejmech.2024.116902","title":"Chemical synthesis and enzymatic late-stage diversification of novel pantothenate analogues with antiplasmodial activity","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Enzyme; Chemical synthesis; Stereochemistry; Biochemistry; Diversification (marketing strategy); In vitro","score_opus":0.03661151035185641,"score_gpt":0.24724418627486533,"score_spread":0.2106326759230089,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402892953","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9972099,0.0002602123,0.00053002354,0.0002926472,0.000073916,0.000040621013,0.00003553619,0.000017394746,0.0015397698],"genre_scores_gemma":[0.9993486,0.00024303545,0.000108127926,0.00006815103,0.00015168209,4.4213104e-7,4.7163863e-7,0.000014607971,0.000064915286],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989029,0.000106798914,0.00026581573,0.00020870865,0.00037613686,0.00013964],"domain_scores_gemma":[0.9990808,0.0003580449,0.00023230455,0.00011363645,0.000041721934,0.00017351663],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039250834,0.00012728357,0.00024314302,0.00004347959,0.000034784,0.000029638164,0.00020930413,0.000023517065,0.00005626062],"category_scores_gemma":[0.0006529704,0.00008158397,0.000074861426,0.0001339368,0.0002842911,0.0001238146,0.00005007381,0.0002901462,0.0000022782938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00034714045,0.00010598894,0.000065656604,0.00025532083,0.000017834755,0.00058185245,0.00009827553,0.000021316255,0.9946897,0.000033452172,0.000035046494,0.0037484346],"study_design_scores_gemma":[0.000614729,0.00012552933,0.0033158592,0.00036308359,0.00015459006,0.00026760707,0.000048720085,0.00089967495,0.99345773,0.000011494326,0.0006346369,0.00010635515],"about_ca_topic_score_codex":0.0000010256421,"about_ca_topic_score_gemma":2.1749004e-8,"teacher_disagreement_score":0.0036420794,"about_ca_system_score_codex":0.000010153374,"about_ca_system_score_gemma":0.000042793352,"threshold_uncertainty_score":0.33268976},"labels":[],"label_agreement":null},{"id":"W4404453247","doi":"10.1016/j.ejmech.2024.117065","title":"Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulations","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Waterloo","funders":"Natural Science Foundation of Hubei Province; National Natural Science Foundation of China","keywords":"Chemistry; Tricyclic; Quinazoline; Scaffold; Stereochemistry; Pharmacology; Combinatorial chemistry","score_opus":0.033181776399219695,"score_gpt":0.2800532128120895,"score_spread":0.2468714364128698,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404453247","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97971106,0.009301026,0.0012821391,0.0006548696,0.00008491268,0.000047315665,0.000030564053,0.000030588464,0.008857546],"genre_scores_gemma":[0.99770457,0.00025917348,0.0008654175,0.00003715786,0.0008590616,0.0000018210771,0.000007877094,0.000041510004,0.0002234163],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9981475,0.000029152887,0.000997554,0.00022079745,0.00040966403,0.00019531461],"domain_scores_gemma":[0.99883556,0.00014274693,0.00044454206,0.00021093992,0.00013619628,0.0002300392],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006032015,0.00020363895,0.00039695084,0.00007559607,0.000072995965,0.000039228355,0.00020051765,0.000046191835,0.00037679804],"category_scores_gemma":[0.00018248544,0.00016702745,0.00016800014,0.00016199792,0.00013831438,0.000082018836,0.00007930202,0.00035169287,0.0000046211503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000042195985,0.0001658047,0.00006926749,0.00047688917,0.00011367953,0.00011633713,0.0005687197,0.000051650728,0.9761944,0.000027411983,0.0002620702,0.021911565],"study_design_scores_gemma":[0.0016858662,0.00013899762,0.00027046175,0.0038490358,0.00027935763,0.0012318254,0.0018944936,0.001320384,0.97319007,0.000041681888,0.015822992,0.00027480922],"about_ca_topic_score_codex":0.000003709478,"about_ca_topic_score_gemma":1.3525225e-7,"teacher_disagreement_score":0.021636756,"about_ca_system_score_codex":0.00006374547,"about_ca_system_score_gemma":0.000105635256,"threshold_uncertainty_score":0.6811182},"labels":[],"label_agreement":null},{"id":"W4405835659","doi":"10.1016/j.ejmech.2024.117208","title":"Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Universiteit Gent; Vlaamse regering; University of Toronto; Fonds Wetenschappelijk Onderzoek","keywords":"Chemistry; Zinc finger; Ubiquitin; Biochemistry; Cell biology; Transcription factor; Gene","score_opus":0.017915205659183815,"score_gpt":0.25447417654020266,"score_spread":0.23655897088101885,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405835659","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9882905,0.0048443354,0.0031846876,0.00064494554,0.00022109374,0.00004342571,0.0000134408,0.000006669946,0.002750887],"genre_scores_gemma":[0.99587697,0.00011659831,0.0011928873,0.00003807546,0.0023169464,0.0000012729975,0.000010012249,0.000040652994,0.00040657152],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99831605,0.00015565392,0.0005483905,0.00022456302,0.0005278301,0.0002274914],"domain_scores_gemma":[0.9991263,0.00018063196,0.00023596107,0.00015396859,0.0001567848,0.00014631417],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002826052,0.00016154337,0.00019358541,0.000064701024,0.0001280034,0.000039055918,0.00021921413,0.000058031605,0.000072189505],"category_scores_gemma":[0.00087190256,0.00011543005,0.00014863562,0.00013529809,0.00031842384,0.000009965693,0.00015401821,0.00051182084,0.0000026637258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001109969,0.000026433412,0.0001245012,0.00017619037,0.00010663932,0.00014826427,0.00017813305,0.000041775183,0.9869695,0.0000037745897,0.009074476,0.0030393489],"study_design_scores_gemma":[0.00045937308,0.00013560017,0.00017617851,0.0010027642,0.000051002557,0.0010449078,0.0010630883,0.00007968708,0.9652158,0.000002367453,0.030637821,0.00013142114],"about_ca_topic_score_codex":0.0000017593364,"about_ca_topic_score_gemma":2.043567e-7,"teacher_disagreement_score":0.02175368,"about_ca_system_score_codex":0.000028122171,"about_ca_system_score_gemma":0.00013790977,"threshold_uncertainty_score":0.47071007},"labels":[],"label_agreement":null},{"id":"W4408982587","doi":"10.1016/j.ejmech.2025.117579","title":"Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia; Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacokinetics; Selectivity; Pharmacology; Biochemistry","score_opus":0.011095039464258225,"score_gpt":0.279489163645235,"score_spread":0.2683941241809768,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4408982587","genre_codex":"methods","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.4822346,0.0022334082,0.5010686,0.0030777075,0.00041193145,0.000041567935,7.382838e-7,0.000011843685,0.010919629],"genre_scores_gemma":[0.9797473,0.00006634969,0.019717414,0.00018642175,0.00021119491,1.3873002e-7,1.2433861e-7,0.0000047521025,0.0000663004],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987658,0.0003118675,0.00038071783,0.00011467797,0.00032628488,0.00010062762],"domain_scores_gemma":[0.99883515,0.00045168557,0.00031197746,0.0001479545,0.00018919917,0.0000640434],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0022331234,0.000088145134,0.00015988515,0.000048371556,0.000054984677,0.00003236588,0.00057889527,0.000011489264,0.00000474544],"category_scores_gemma":[0.00034075926,0.00006094103,0.000059088117,0.00029049267,0.00012536022,0.00011325368,0.00022312379,0.00033864618,2.7154934e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020331185,0.00026759793,0.0015628097,0.00060833624,0.00040172183,0.00051131315,0.0041400227,0.030559506,0.5240669,0.0014679763,0.009986017,0.4262245],"study_design_scores_gemma":[0.0035109392,0.00033558617,0.016785353,0.0014136771,0.00022489669,0.0014633529,0.0005882892,0.075847015,0.88216555,0.002736214,0.014557061,0.00037205985],"about_ca_topic_score_codex":6.4709127e-7,"about_ca_topic_score_gemma":2.8772487e-8,"teacher_disagreement_score":0.49751273,"about_ca_system_score_codex":0.00002398462,"about_ca_system_score_gemma":0.00014099781,"threshold_uncertainty_score":0.2485103},"labels":[],"label_agreement":null},{"id":"W4410118566","doi":"10.1016/j.ejmech.2025.117727","title":"Characterization of a water soluble quininib prodrug that blocks metabolic activity and proliferation of multiple cancer cell lines","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Trinity College","funders":"Irish Research Council; HORIZON EUROPE Framework Programme; Trinity College Dublin; University College Dublin; Horizon 2020 Framework Programme; Breakthrough Cancer Research; Universidad Mayor","keywords":"Chemistry; Prodrug; Cell growth; Cell culture; Cancer cell lines; Chemical synthesis; Cancer; Cancer cell; Biological activity; Biochemistry; Stereochemistry; In vitro; Internal medicine","score_opus":0.018614410927294874,"score_gpt":0.2352206413671395,"score_spread":0.21660623043984462,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4410118566","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9962028,0.0005715125,0.00010385851,0.00030506583,0.00007900812,0.000041461808,0.000013428803,0.000007135694,0.0026756886],"genre_scores_gemma":[0.99840385,0.0005176738,0.000061148225,0.000024114504,0.0003138395,0.0000019745125,0.000006756642,0.000009110833,0.0006615224],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99899966,0.00007379561,0.00041942546,0.00015219119,0.00022394238,0.00013096852],"domain_scores_gemma":[0.99898845,0.000076607226,0.0005478462,0.00012637713,0.00019423114,0.00006646729],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00059366337,0.00014049768,0.00039527714,0.000021370453,0.000038670518,0.0000110317005,0.00016128867,0.000058428297,0.00026646533],"category_scores_gemma":[0.00015520374,0.00008469997,0.000086040054,0.000046356992,0.00010792646,0.000108437336,0.00006717434,0.0002179813,1.9790517e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00035431827,0.00021366878,0.015274046,0.0005162594,0.00006513613,0.0000066378134,0.00020318358,0.0000015811823,0.9741977,2.69744e-7,0.000021636415,0.009145596],"study_design_scores_gemma":[0.00077275536,0.00003838253,0.011435111,0.00037185042,0.00010663955,0.000014496457,0.000110003806,0.00007001644,0.98586047,0.0000035396174,0.0011381613,0.00007856064],"about_ca_topic_score_codex":0.000015265525,"about_ca_topic_score_gemma":0.0000016994261,"teacher_disagreement_score":0.011662817,"about_ca_system_score_codex":0.000018292983,"about_ca_system_score_gemma":0.00005645851,"threshold_uncertainty_score":0.34539643},"labels":[],"label_agreement":null},{"id":"W4411582977","doi":"10.1016/j.ejmech.2025.117889","title":"Discovery of novel fluorescent amino-pyrazolines that detect and kill Mycobacterium tuberculosis","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Discovery Centre","funders":"Engineering and Physical Sciences Research Council; Royal Society; University of Birmingham; Medical Research Council; University of Balamand; Royal Society of Chemistry","keywords":"Chemistry; Mycobacterium tuberculosis; Fluorescence; Tuberculosis; Microbiology; Stereochemistry; Computational biology; Combinatorial chemistry","score_opus":0.023952892536529054,"score_gpt":0.2952237103207795,"score_spread":0.27127081778425044,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4411582977","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98460907,0.004533493,0.0010512238,0.0053617316,0.00021312365,0.000086127584,0.0000124497765,0.000010094653,0.004122716],"genre_scores_gemma":[0.99460655,0.0026117673,0.001068359,0.00067040225,0.0005853955,7.8349905e-7,0.000007587578,0.000021409729,0.00042773745],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9981084,0.00013797516,0.0007826846,0.00021886897,0.00043204846,0.00032005316],"domain_scores_gemma":[0.9985505,0.00027621648,0.00034904256,0.0002716295,0.00026590415,0.00028670585],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014781051,0.00020817101,0.0007158118,0.00014235334,0.00004292565,0.00001523523,0.00021833491,0.00006669258,0.000040830226],"category_scores_gemma":[0.0017363538,0.00014544897,0.00020707525,0.0001683633,0.00035446958,0.000102920145,0.00013582251,0.0006410703,0.0000017221638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016896392,0.00015636925,0.03134548,0.0012865289,0.00044307148,0.00047885437,0.00009734412,0.00000360147,0.9447973,0.00000876327,0.0062893354,0.013403728],"study_design_scores_gemma":[0.0070323152,0.0011048217,0.38949907,0.0036442794,0.0006409302,0.0032020584,0.00058504887,0.00009162286,0.5863675,0.000031671687,0.0075712516,0.00022945328],"about_ca_topic_score_codex":0.000011162516,"about_ca_topic_score_gemma":7.318234e-7,"teacher_disagreement_score":0.35842982,"about_ca_system_score_codex":0.000068972346,"about_ca_system_score_gemma":0.00016167146,"threshold_uncertainty_score":0.5931237},"labels":[],"label_agreement":null},{"id":"W4412487628","doi":"10.1016/j.ejmech.2025.117951","title":"The roles of fused-cyclopropanes in medicinal chemistry: Insights from the past decade","year":2025,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Chemistry; Organic chemistry","score_opus":0.016722467556305493,"score_gpt":0.26578136174401407,"score_spread":0.24905889418770857,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4412487628","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.002162669,0.969158,0.000021756176,0.00029900073,0.00038383718,0.00016116771,0.00005387471,0.000031037758,0.027728647],"genre_scores_gemma":[0.0038621305,0.9900353,0.00007068837,0.00004258959,0.0044372333,0.000012324481,0.00010342454,0.00013096824,0.00130537],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99337876,0.00049040164,0.0032608397,0.0006121271,0.0017066359,0.00055124104],"domain_scores_gemma":[0.99165976,0.0023915449,0.00393845,0.0012481225,0.00043183108,0.0003302844],"candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0015580757,0.0009387961,0.0023886526,0.000090954934,0.0002378225,0.000079886144,0.0031774398,0.0003775288,0.00045490992],"category_scores_gemma":[0.001703315,0.00051019556,0.0009265642,0.0005531512,0.0006008976,0.00008533545,0.0004155615,0.0039049746,0.000015145395],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022454771,0.00015546185,0.000023603096,0.02624821,0.000694619,0.0017684982,0.00090615556,0.0000039942393,0.018720478,0.0000067111846,0.0022039115,0.9490438],"study_design_scores_gemma":[0.0012229786,0.000040936575,0.000011529738,0.059556685,0.00161848,0.0013204757,0.0042177774,0.0000018366957,0.012549911,0.000048115122,0.91896635,0.00044490962],"about_ca_topic_score_codex":0.000015204895,"about_ca_topic_score_gemma":0.000008550674,"teacher_disagreement_score":0.9485989,"about_ca_system_score_codex":0.0004095839,"about_ca_system_score_gemma":0.0012694281,"threshold_uncertainty_score":0.99973494},"labels":[],"label_agreement":null},{"id":"W4413436135","doi":"10.1016/j.ejmech.2025.118076","title":"Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Structural Genomics Consortium; National Institute of Allergy and Infectious Diseases; Innovative Medicines Initiative; Deutsche Krebshilfe; Wellcome Trust","keywords":"Chemistry; Pyrimidine; Kinase; Stereochemistry; Combinatorial chemistry; Biochemistry","score_opus":0.009307123051497137,"score_gpt":0.2605608952207409,"score_spread":0.25125377216924377,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4413436135","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9866606,0.0030019858,0.0036597545,0.00044061162,0.00011672414,0.000056575598,0.0000025057182,0.000005326483,0.0060558915],"genre_scores_gemma":[0.99458474,0.000049551883,0.0043333434,0.00022652662,0.00034818088,0.0000010755382,0.000031009728,0.000022426719,0.00040314597],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982492,0.00011598398,0.00075268757,0.00022623772,0.00039291533,0.00026298937],"domain_scores_gemma":[0.99894744,0.000020081376,0.00032827514,0.00021365233,0.00029560056,0.00019496854],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013711107,0.00018303208,0.0002545494,0.00006425317,0.0000661204,0.000010476652,0.00044286973,0.000080367034,0.000048611164],"category_scores_gemma":[0.00052663626,0.00015294712,0.00016601269,0.00016272554,0.00018476445,0.000002259729,0.00018331995,0.00035405636,0.000002473508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022423248,0.000112767215,0.00017626862,0.00024977233,0.000084120256,0.00010616422,0.000032931774,0.000016356697,0.9828638,0.0000012145573,0.0040209675,0.012111448],"study_design_scores_gemma":[0.0011641383,0.00010663445,0.00020794578,0.00032771708,0.00003018407,0.00003020383,0.00013512469,0.000013893949,0.935598,0.0000037483494,0.06225978,0.00012261029],"about_ca_topic_score_codex":5.0097725e-7,"about_ca_topic_score_gemma":1.957304e-7,"teacher_disagreement_score":0.05823881,"about_ca_system_score_codex":0.000031125506,"about_ca_system_score_gemma":0.00037916747,"threshold_uncertainty_score":0.62370026},"labels":[],"label_agreement":null},{"id":"W4413922863","doi":"10.1016/j.ejmech.2025.118107","title":"Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SignalChem (Canada); Spinal Cord Injury BC","funders":"European Synchrotron Radiation Facility","keywords":"Chemistry; Carbonic anhydrase; Programmed cell death; Dual (grammatical number); Peroxidase; Glutathione peroxidase; Glutathione; Tumor cells; Biochemistry; Enzyme; GPX4; Cancer research; Apoptosis","score_opus":0.016032975110936768,"score_gpt":0.25686171200440433,"score_spread":0.24082873689346757,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4413922863","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98916095,0.0007121291,0.0023402208,0.00020144046,0.00010287935,0.000085180014,0.000015570124,0.0000045563943,0.007377045],"genre_scores_gemma":[0.99832636,0.00007653895,0.0003153206,0.00030266916,0.00039641777,0.0000018871551,0.00003970205,0.000016866587,0.00052421505],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989601,0.000056793895,0.0004693498,0.00019363294,0.00017166135,0.00014847038],"domain_scores_gemma":[0.9991054,0.000020692773,0.00034250764,0.00013305027,0.00026614522,0.0001322315],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005575967,0.00015197921,0.00020341459,0.00005165508,0.000057149013,0.000014277968,0.00007350515,0.000057732672,0.00002230886],"category_scores_gemma":[0.00021739186,0.0001361391,0.0001104557,0.000072151546,0.000070809445,0.000009027014,0.000041194653,0.00020166923,6.9996776e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00050741294,0.00014716819,0.000042557847,0.00019257056,0.000036598274,0.000042482625,0.000037427395,0.000024571389,0.9974229,0.000019492143,0.0011607615,0.00036611286],"study_design_scores_gemma":[0.0034364024,0.0012297007,0.00033195276,0.00029297714,0.000098441116,0.00032656244,0.0005405622,0.00005504593,0.9925887,0.000024148227,0.0009577737,0.00011774255],"about_ca_topic_score_codex":0.0000026999815,"about_ca_topic_score_gemma":4.7310007e-7,"teacher_disagreement_score":0.009165404,"about_ca_system_score_codex":0.000022499853,"about_ca_system_score_gemma":0.00020502007,"threshold_uncertainty_score":0.55515915},"labels":[],"label_agreement":null},{"id":"W4415141897","doi":"10.1016/j.ejmech.2025.118259","title":"Development of dual AR/ARV7 degraders with 3,5-dimethylisoxazole to overcome antiandrogen resistance in castration-resistant prostate cancer","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Natural Science Foundation of Beijing Municipality; National Natural Science Foundation of China; McGill University","keywords":"Androgen receptor; Prostate cancer; Antiandrogen; Drug resistance; Blockade; Androgen Receptor Antagonists; Downregulation and upregulation; Dual (grammatical number); Prostate","score_opus":0.02053667857527498,"score_gpt":0.30500522927693646,"score_spread":0.2844685507016615,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4415141897","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98548865,0.005442912,0.0000567667,0.002536389,0.000059042653,0.00021459759,0.00000970208,0.000006717369,0.006185196],"genre_scores_gemma":[0.9920545,0.00025390027,0.0046939533,0.000120013654,0.000090732065,0.000005928004,0.000008063569,0.000020960799,0.0027519464],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99811774,0.0000653751,0.0007120816,0.00019777432,0.00062863,0.0002784214],"domain_scores_gemma":[0.99898815,0.00004112961,0.00025898643,0.00016605417,0.0003101565,0.00023554091],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008156355,0.00017483543,0.00041012643,0.00018875532,0.000053404503,0.000013179591,0.00014567925,0.000028642977,0.00006179528],"category_scores_gemma":[0.000080252525,0.00012047898,0.00005646504,0.0005244387,0.00013089937,0.000058850354,0.00003559781,0.00037005192,0.0000017049393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.012118454,0.00037034697,0.026373273,0.0016574995,0.00056898926,0.0046222135,0.005651977,0.00005304415,0.9386346,0.000007877614,0.0022690052,0.0076727234],"study_design_scores_gemma":[0.011397268,0.0005793973,0.15580375,0.009428432,0.00021676326,0.00016420543,0.0036886816,0.0000034090103,0.79996693,0.0000117550035,0.018490227,0.00024916345],"about_ca_topic_score_codex":0.000012274373,"about_ca_topic_score_gemma":0.000054069253,"teacher_disagreement_score":0.13866764,"about_ca_system_score_codex":0.00027942864,"about_ca_system_score_gemma":0.001490103,"threshold_uncertainty_score":0.491299},"labels":[],"label_agreement":null},{"id":"W4415755556","doi":"10.1016/j.ejmech.2025.118331","title":"Structural insights into frog skin-derived cyclic peptides as selective matriptase inhibitors","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Liver physiology and pathology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Narodowe Centrum Nauki","keywords":"Proteases; Peptide; Cyclic peptide; Serine protease; Structure–activity relationship; Transmembrane protein; Potency; Protease; Serine; Selectivity","score_opus":0.006983929424193086,"score_gpt":0.2546702286606381,"score_spread":0.247686299236445,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4415755556","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9741,0.0024176175,0.0000388867,0.00083603774,0.00052081526,0.00007759441,0.0000011540884,0.00002248122,0.021985423],"genre_scores_gemma":[0.99613565,0.00012071767,0.0003519112,0.00109797,0.001421159,7.020937e-7,0.000013950531,0.000020906204,0.0008370201],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99836624,0.0002771414,0.0006174248,0.00023625122,0.00027395226,0.00022896951],"domain_scores_gemma":[0.9987384,0.00011768273,0.00037792273,0.00021555237,0.00030391783,0.00024654108],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039418737,0.00023104838,0.00051357725,0.00012783844,0.00012761679,0.000009531751,0.00024274424,0.000096118296,0.00018043714],"category_scores_gemma":[0.00047283227,0.00017020019,0.00019234505,0.00022982892,0.0003623541,0.00008283986,0.00008267942,0.0010260936,0.00004033984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015712555,0.00008594662,0.0035871272,0.00027119147,0.00039784313,0.004921483,0.002802226,0.0000069167572,0.974134,0.00002408934,0.008324801,0.0038730986],"study_design_scores_gemma":[0.00677715,0.0014605327,0.10029271,0.0013059002,0.0007119681,0.005396341,0.0024807716,0.000017401608,0.87335443,0.0016929152,0.0062055876,0.00030430566],"about_ca_topic_score_codex":0.0000067849096,"about_ca_topic_score_gemma":4.3233229e-7,"teacher_disagreement_score":0.10077961,"about_ca_system_score_codex":0.000100877274,"about_ca_system_score_gemma":0.00031537935,"threshold_uncertainty_score":0.6940563},"labels":[],"label_agreement":null},{"id":"W4416428032","doi":"10.1016/j.ejmech.2025.118377","title":"Lactate dehydrogenase inhibitors: A promising candidate against aging and fibrosis","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Hospital for Sick Children","funders":"Sichuan Medical Association; Sichuan Province Science and Technology Support Program; West China School of Stomatology, Sichuan University; National Natural Science Foundation of China; Health Commission of Sichuan Province; Natural Science Foundation of Sichuan Province; Fundamental Research Funds for the Central Universities; Sichuan University","keywords":"Nicotinamide adenine dinucleotide; Allosteric regulation; NAD+ kinase; Glycolysis; Lactate dehydrogenase; Enzyme; Prodrug; Drug discovery; Druggability","score_opus":0.004884129292773603,"score_gpt":0.22884001456770914,"score_spread":0.22395588527493554,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4416428032","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9771321,0.01634052,0.00030404405,0.00040418902,0.00048262055,0.000047538306,0.00000643013,0.000006347007,0.0052762222],"genre_scores_gemma":[0.99316853,0.0023546887,0.00035239817,0.00046531938,0.0028249277,7.388504e-7,0.000012972816,0.000023489267,0.00079691847],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989147,0.000090087895,0.0004063748,0.00020611771,0.00017265257,0.00021004933],"domain_scores_gemma":[0.9992521,0.000012610742,0.00025378694,0.00017588458,0.000117270254,0.00018839088],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006831331,0.00016565082,0.00022257237,0.000047731835,0.00008343962,0.000035751425,0.00017943939,0.00004274713,0.000008924086],"category_scores_gemma":[0.00018705388,0.00014447267,0.000100063015,0.00009188828,0.000116893694,0.000007781449,0.000102540886,0.00024422636,9.0564487e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00014905244,0.000021735954,0.0002835085,0.00012725242,0.00008782063,0.00006044541,0.000108783555,0.000013214828,0.972865,6.0060256e-7,0.006949533,0.019333094],"study_design_scores_gemma":[0.0017393236,0.000084557134,0.0004894412,0.0005803557,0.000098481425,0.00027870675,0.00023777357,0.000012354383,0.77122056,0.000007269885,0.22509637,0.00015478198],"about_ca_topic_score_codex":0.0000031000427,"about_ca_topic_score_gemma":0.0000010691512,"teacher_disagreement_score":0.21814685,"about_ca_system_score_codex":0.00001973406,"about_ca_system_score_gemma":0.00017494489,"threshold_uncertainty_score":0.58914244},"labels":[],"label_agreement":null},{"id":"W4417436645","doi":"10.1016/j.ejmech.2025.118492","title":"Overcoming multidrug- and extensively drug-resistant Salmonella Typhi with natural product-metal synergy: Evidence of DNA polymerase inhibition and cell membrane disruption","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lakehead University","funders":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center); Guangxi Normal University; Higher Education Commision, Pakistan; Natural Science Foundation of Guangxi Province","keywords":"Salmonella typhi; Typhoid fever; Antimicrobial; DNA; Hemolysis; Polymerase; Bacteria; Salmonella; Antibacterial agent","score_opus":0.015069204095051527,"score_gpt":0.23815829418246004,"score_spread":0.22308909008740851,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4417436645","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9664816,0.030822372,0.000036415,0.0009963497,0.000071404545,0.00009516634,0.0000022338215,0.00000773207,0.0014866844],"genre_scores_gemma":[0.9973287,0.0007945433,0.0005809894,0.00012217803,0.0002126075,5.6746626e-7,0.0000023532652,0.000019421412,0.00093863613],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9984634,0.00017310877,0.0005674952,0.00023165245,0.00041124364,0.00015308423],"domain_scores_gemma":[0.99879646,0.00016551428,0.00042667412,0.00017295504,0.00029282886,0.00014557023],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009526814,0.00019789085,0.0004818219,0.00008942553,0.0000863634,0.000023636248,0.00007525027,0.000020786943,0.00002248427],"category_scores_gemma":[0.00048784504,0.00012784505,0.00006985469,0.00012941855,0.00034948872,0.0001384321,0.000058920723,0.00036566315,5.258631e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0031391652,0.000068390626,0.00030859036,0.0018035402,0.00008168391,0.00035985172,0.00039575718,0.0000018248729,0.99078816,0.0000031926718,0.000094514005,0.002955336],"study_design_scores_gemma":[0.0017172218,0.0003497124,0.008818424,0.007300204,0.0004460473,0.0011367206,0.00104833,0.000058896025,0.9787044,0.000003835061,0.00028539845,0.00013081188],"about_ca_topic_score_codex":0.000010288018,"about_ca_topic_score_gemma":7.402179e-7,"teacher_disagreement_score":0.030847061,"about_ca_system_score_codex":0.000029205647,"about_ca_system_score_gemma":0.00010911707,"threshold_uncertainty_score":0.521337},"labels":[],"label_agreement":null},{"id":"W654933125","doi":"10.1016/j.ejmech.2015.06.006","title":"Synthesis and cancer cell growth inhibitory activity of icaritin derivatives","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Medicinal Plant Pharmacodynamics Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lakehead University","funders":"National Natural Science Foundation of China","keywords":"Chemistry; Estrogen receptor; Cytotoxicity; Substituent; Cytotoxic T cell; Cancer cell; Stereochemistry; Tamoxifen; Cell growth; Structure–activity relationship; In vitro; Cancer; Pharmacology; Breast cancer; Biochemistry; Internal medicine","score_opus":0.13091592935256582,"score_gpt":0.41828979711320285,"score_spread":0.287373867760637,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W654933125","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96729064,0.0054232324,0.00009087313,0.0008256397,0.00033021293,0.0000677601,0.000035847774,0.00000933924,0.025926473],"genre_scores_gemma":[0.9957082,0.002867235,0.000112143876,0.00018015037,0.00083186233,0.0000018983616,0.0000015367837,0.00002463405,0.0002722919],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99751204,0.000942106,0.0005168566,0.00017273448,0.0005737209,0.0002825677],"domain_scores_gemma":[0.9973863,0.00075843855,0.0005535684,0.000100812744,0.000470765,0.00073014485],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0037821082,0.00018726592,0.00040678223,0.00006350507,0.000057469068,0.000007708565,0.0003732184,0.00008542653,0.0005880903],"category_scores_gemma":[0.0009812453,0.00015526146,0.000070656555,0.000121909376,0.0005262448,0.00013696415,0.00012161241,0.0012852607,0.0000041168914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014811102,0.0002399399,0.0053254934,0.0005560354,0.00017859257,0.00089620525,0.0010199437,0.000029419673,0.96714157,0.0000045996762,0.008046244,0.0150808515],"study_design_scores_gemma":[0.0025509328,0.00025687926,0.0016175376,0.0003029245,0.00025467653,0.00050257234,0.00094359554,0.0004248663,0.985933,0.00002041929,0.0070292978,0.00016330798],"about_ca_topic_score_codex":0.000021123084,"about_ca_topic_score_gemma":8.2443654e-7,"teacher_disagreement_score":0.028417626,"about_ca_system_score_codex":0.0001123649,"about_ca_system_score_gemma":0.00032471376,"threshold_uncertainty_score":0.6439176},"labels":[],"label_agreement":null},{"id":"W7117323255","doi":"10.1016/j.ejmech.2025.118536","title":"Exploring the structure-activity relationship of brevibacillin: Discovery of synthetic analogues with an extended spectrum of activity","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Centre Hospitalier Universitaire de Québec","keywords":"Enterococcus faecium; Lipopeptide; Acinetobacter baumannii; Enterococcus faecalis; Antimicrobial; Escherichia coli; Structure–activity relationship; Klebsiella pneumoniae; Bacteria","score_opus":0.03129767181160763,"score_gpt":0.23682695023483996,"score_spread":0.20552927842323232,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7117323255","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9967903,0.00045931104,0.0010972337,0.0002543691,0.00013311266,0.00004697944,0.00003277077,0.000004294023,0.001181621],"genre_scores_gemma":[0.9995262,0.000107656524,0.000064824846,0.000009257002,0.000053401487,1.8809077e-7,0.0000039448796,0.000010643976,0.0002238727],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988579,0.00035296677,0.0004292854,0.00012878326,0.00008983263,0.00014119377],"domain_scores_gemma":[0.9984724,0.0002953099,0.0008389542,0.0002682573,0.00010585646,0.000019199808],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00063136284,0.000147075,0.0004544293,0.000065226806,0.00007468746,0.000006294572,0.00029944256,0.000036936523,0.000038562626],"category_scores_gemma":[0.00017461296,0.00008989561,0.00012547932,0.00014804053,0.000714885,0.0002647955,0.00005375892,0.00053318276,3.2918396e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.001289624,0.00014222623,0.002366365,0.00027491729,0.00025237244,0.00001590608,0.00035078707,0.000057875775,0.99169064,0.00009784056,0.000035779758,0.0034256699],"study_design_scores_gemma":[0.00062337134,0.00040448597,0.09533429,0.0008022304,0.00017530152,0.00018165859,0.0009876775,0.0000013916011,0.9012752,0.000082487575,0.000057998554,0.00007390672],"about_ca_topic_score_codex":0.000024439494,"about_ca_topic_score_gemma":0.0000045918173,"teacher_disagreement_score":0.09296793,"about_ca_system_score_codex":0.000022050997,"about_ca_system_score_gemma":0.0001178557,"threshold_uncertainty_score":0.36658368},"labels":[],"label_agreement":null},{"id":"W7117488796","doi":"10.1016/j.ejmech.2025.118532","title":"Chemical modification of STL427944 toward morpholine-based 1,3,5-triazines as anticancer agents targeting FOXM1: green synthesis, biological evaluation and ADME-Tox profiling in a colorectal cancer model","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Narodowe Centrum Badań i Rozwoju; National Center for Research and Development; Fundacja na rzecz Nauki Polskiej; Canadian Institutes of Health Research; European Commission","keywords":"Colorectal cancer; In vivo; Cytotoxicity; Effector; Cell culture; Cell growth; Potency; Downregulation and upregulation; Zebrafish","score_opus":0.05281777087899536,"score_gpt":0.3230638894044542,"score_spread":0.2702461185254588,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7117488796","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99624157,0.0009607972,0.0005018467,0.00067660224,0.000057600864,0.000080110054,0.000018246814,0.0000134942065,0.0014497367],"genre_scores_gemma":[0.9986979,0.00027072706,0.0006063546,0.00006709042,0.00027723305,0.000014773525,0.000024572137,0.000019641537,0.000021725396],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99789035,0.00012656773,0.0009828787,0.0002834202,0.0005168049,0.00019996281],"domain_scores_gemma":[0.9984984,0.0002243865,0.00069031224,0.00012925274,0.00034717095,0.00011049814],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0012660311,0.00020973434,0.00045021303,0.000087948814,0.000040558065,0.00002019431,0.00030147794,0.00009486689,0.0003368562],"category_scores_gemma":[0.0012690744,0.0001762679,0.00010824098,0.00014746847,0.00013986259,0.000070684335,0.000063088686,0.00033111146,5.920411e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00061297003,0.00013112293,0.008484602,0.00035468308,0.000057358196,0.000019347734,0.0001261856,0.00057546963,0.9797076,0.0000025230827,0.000043603442,0.009884515],"study_design_scores_gemma":[0.0015922235,0.000020204743,0.0023776786,0.0011847927,0.00012673535,0.000022015169,0.00025865677,0.05686656,0.9372972,0.000035597343,0.00006483611,0.00015347968],"about_ca_topic_score_codex":0.000010384249,"about_ca_topic_score_gemma":2.483691e-7,"teacher_disagreement_score":0.05629109,"about_ca_system_score_codex":0.00015768169,"about_ca_system_score_gemma":0.00029165702,"threshold_uncertainty_score":0.71879965},"labels":[],"label_agreement":null},{"id":"W7117737049","doi":"10.1016/j.ejmech.2025.118545","title":"From molecular design to immune remodeling: Advances in perylene diimide-based multimodal cancer therapies","year":2025,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ministry of Education and Child Care","funders":"Henan Provincial Science and Technology Research Project; Science and Technology Department, Henan Province; Education Department of Henan Province; Zhengzhou Municipal Science and Technology Bureau","keywords":"Perylene; Immune system; Immune checkpoint; Photothermal therapy; Endoplasmic reticulum; Rational design; Transcription factor; Immunogenic cell death","score_opus":0.008087645374149771,"score_gpt":0.24089534161788118,"score_spread":0.2328076962437314,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7117737049","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.55846757,0.052367326,0.38704503,0.00039072993,0.000544302,0.000093064744,0.000007624626,0.000043077056,0.0010412668],"genre_scores_gemma":[0.99113816,0.0011182798,0.007203961,0.00018106407,0.00028076518,0.0000027934427,0.0000024127241,0.000046939247,0.000025608495],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99868804,0.000049280607,0.00059894554,0.00013890275,0.0002952928,0.0002295515],"domain_scores_gemma":[0.9993873,0.0001075949,0.000084212996,0.000199534,0.000104292696,0.00011702418],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005151795,0.00020791213,0.0003324446,0.00010474867,0.00002503068,0.000019452178,0.00039625357,0.00003818128,0.00006866913],"category_scores_gemma":[0.00011600542,0.00018242915,0.00008981711,0.00022192208,0.000040105973,0.000105564184,0.000022721688,0.0004363174,0.0000028988088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00024665572,0.000017389195,0.00011212804,0.000064581895,0.00005531445,0.00021632179,0.0003324474,0.21897651,0.75001734,3.337078e-7,0.000070059665,0.029890899],"study_design_scores_gemma":[0.0027103284,0.00008390517,0.0004952166,0.0021563387,0.000071900104,0.000011488443,0.00038418098,0.01451429,0.9750271,0.00013276147,0.0041519827,0.00026051427],"about_ca_topic_score_codex":0.000014202283,"about_ca_topic_score_gemma":0.0000012525136,"teacher_disagreement_score":0.4326706,"about_ca_system_score_codex":0.00020735592,"about_ca_system_score_gemma":0.00011467455,"threshold_uncertainty_score":0.7439245},"labels":[],"label_agreement":null}]}