{"meta":{"query_hash":"54dce2eeb2fa","filters":{"venue":"Signal Transduction and Targeted Therapy"},"cohort_total":81,"direct_labels_cover":0,"predictions_cover":81,"exported":81,"export_cap":100000,"truncated":false,"label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"permalink":"https://metacan.xera.ac/q/54dce2eeb2fa","api":"https://metacan.xera.ac/api/v1/cohort?venue=Signal+Transduction+and+Targeted+Therapy"},"results":[{"id":"W2266260677","doi":"10.1038/sigtrans.2015.2","title":"Intravenous immune globulin suppresses angiogenesis in mice and humans","year":2016,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Eye Institute; National Heart, Lung, and Blood Institute; Institute of Genetics; National Institutes of Health; Ellison Medical Foundation; American Heart Association; Associazione Italiana per la Ricerca sul Cancro; Arnold and Mabel Beckman Initiative for Macular Research; Fundação Champalimaud; Alcon Japan; Ministério da Saúde; Research to Prevent Blindness; John Templeton Foundation; International Retinal Research Foundation; U.S. Department of Defense","keywords":"Medicine; Antibody; Immunology; Neovascularization; Angiogenesis; Immune system; Polyclonal antibodies; Potency; Pharmacology; Drug; Cancer research; In vitro; Biology","score_opus":0.021243094138722315,"score_gpt":0.2723522101251205,"score_spread":0.2511091159863982,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2266260677","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9825851,0.011793508,0.00018555802,0.0048418446,0.00006333726,0.00024765165,0.000027063565,0.00003007007,0.00022586793],"genre_scores_gemma":[0.97907174,0.01945163,0.0001905149,0.00015782009,0.00014112228,0.0000146024795,0.000013147414,0.000015452377,0.0009439933],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99905604,0.00006827494,0.00020654046,0.0002543283,0.00016927763,0.00024553828],"domain_scores_gemma":[0.99966365,0.00006757214,0.00002387058,0.00007554076,0.00004976935,0.00011960282],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00014987115,0.0001430902,0.0002368345,0.00014382308,0.000085329244,0.000014565066,0.000043345823,0.00007961392,0.0012063668],"category_scores_gemma":[0.0000056946847,0.0000893643,0.00006364492,0.00014687474,0.00018065202,0.000083173705,0.000007371991,0.00009887503,0.00000871872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016763964,0.00015798384,0.008966109,0.00004445107,0.00008882142,0.000031565352,0.000539516,5.779609e-7,0.88891023,0.00030434201,0.000037036283,0.09924294],"study_design_scores_gemma":[0.005779574,0.0012765029,0.32417274,0.00016877176,0.000030240339,0.00023040321,0.00024191274,0.000025212483,0.6410404,0.0013796361,0.025346173,0.00030846315],"about_ca_topic_score_codex":0.00025772117,"about_ca_topic_score_gemma":0.000028949975,"teacher_disagreement_score":0.31520662,"about_ca_system_score_codex":0.000015389458,"about_ca_system_score_gemma":0.000031657015,"threshold_uncertainty_score":0.9997067},"labels":[],"label_agreement":null},{"id":"W2600034981","doi":"10.1038/sigtrans.2017.5","title":"The molecular determinants governing the immunogenicity of Japanese encephalitis live attenuated vaccines","year":2017,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Canada","funders":"","keywords":"Immunogenicity; Japanese encephalitis; Japanese encephalitis vaccine; Virology; Biology; Reverse genetics; Attenuated vaccine; Virus; Gene; Mutant; Immune system; Genetics; Encephalitis; Virulence","score_opus":0.013822451944072176,"score_gpt":0.27304477561667667,"score_spread":0.2592223236726045,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2600034981","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98504645,0.012595078,0.00006650215,0.0015635532,0.00016253127,0.00039914463,0.000024914065,0.000019346246,0.00012251083],"genre_scores_gemma":[0.99631184,0.0031346192,0.000009739474,0.00018496321,0.00011162409,0.000030684696,0.00000709512,0.0000152559805,0.0001941849],"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","domain_scores_codex":[0.9990633,0.000096479045,0.00023353743,0.00019488332,0.00021752692,0.0001942348],"domain_scores_gemma":[0.9991379,0.00006081787,0.00018267073,0.00040908094,0.00013924143,0.00007028989],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022532513,0.00014618598,0.00022193493,0.00001736717,0.00069327594,0.00006765132,0.00019176265,0.000057143618,0.0002469447],"category_scores_gemma":[0.000035099645,0.00007855013,0.00017389958,0.000048236012,0.00020460192,0.00008971905,0.000011247069,0.00013527906,0.00000359882],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0048410576,0.0002226797,0.013291154,0.000057116424,0.0008128531,0.000046533485,0.003426695,0.000013502689,0.81317735,0.00043601732,0.000048106904,0.16362695],"study_design_scores_gemma":[0.0140318135,0.0017950849,0.7311748,0.00024829767,0.00063244515,0.00022090308,0.007437761,0.0028473828,0.23290153,0.0009720861,0.0071792924,0.0005586147],"about_ca_topic_score_codex":0.00053365115,"about_ca_topic_score_gemma":0.000024434627,"teacher_disagreement_score":0.71788365,"about_ca_system_score_codex":0.000009362508,"about_ca_system_score_gemma":0.000039624887,"threshold_uncertainty_score":0.53321886},"labels":[],"label_agreement":null},{"id":"W2760019720","doi":"10.1038/sigtrans.2017.40","title":"Targeting cellular pathways in glioblastoma multiforme","year":2017,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":350,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"John and Lucille Van Geest Foundation; Trent University; Headcase Cancer Trust; Nottingham Trent University","keywords":"Glioblastoma; Medicine; Computational biology; Pathology; Cancer research; Biology","score_opus":0.07417124488464162,"score_gpt":0.32145973666236694,"score_spread":0.24728849177772533,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2760019720","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0023719617,0.9954958,0.00003137065,0.000072644354,0.00030425985,0.0014710509,0.000051104616,0.00007567905,0.00012615352],"genre_scores_gemma":[0.017018117,0.9818946,0.00014838175,0.000031252788,0.00032492538,0.00024290077,0.00020591372,0.000081394304,0.000052497046],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9980048,0.00012687057,0.0006330768,0.00059227936,0.00025170285,0.00039126637],"domain_scores_gemma":[0.9990999,0.000057433997,0.00027463463,0.00032090425,0.00005508168,0.00019206075],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00026624958,0.00055317587,0.001647502,0.00044258387,0.00020580324,0.00006550941,0.00010937482,0.0003981845,0.0005461983],"category_scores_gemma":[0.000012061417,0.00040132602,0.00051552703,0.00020360123,0.000097271295,0.00011635301,0.0000100250745,0.00047694703,0.00004026879],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013766879,0.0004921198,0.00005243465,0.002139248,0.0003548343,0.0002933243,0.00022204797,0.0000016334221,0.0011376026,0.000046978585,0.000044907214,0.9950772],"study_design_scores_gemma":[0.0035938106,0.0006670594,0.000045626733,0.004947271,0.00037261614,0.00014354955,0.000055012155,0.000039594008,0.0018755728,0.00007439522,0.98773086,0.0004546074],"about_ca_topic_score_codex":0.000051423027,"about_ca_topic_score_gemma":0.000007906471,"teacher_disagreement_score":0.9946226,"about_ca_system_score_codex":0.00009805083,"about_ca_system_score_gemma":0.0001437269,"threshold_uncertainty_score":0.99984384},"labels":[],"label_agreement":null},{"id":"W2774630092","doi":"10.1038/sigtrans.2017.59","title":"Prohibitin: a potential therapeutic target in tyrosine kinase signaling","year":2017,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Research Manitoba; Health Sciences Centre Foundation","keywords":"Prohibitin; Cell biology; Biology; Signal transduction; Phosphorylation; Signal transducing adaptor protein; Tyrosine phosphorylation; Mitochondrion","score_opus":0.061452770935596014,"score_gpt":0.33198725823453124,"score_spread":0.2705344872989352,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2774630092","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00072471326,0.99644035,0.0015997405,0.00006728819,0.00024227463,0.00074005686,0.000068749534,0.000018413697,0.000098432756],"genre_scores_gemma":[0.022430439,0.9755651,0.00018359783,0.000052083196,0.0005585813,0.00021972694,0.00052111095,0.000066992274,0.0004023804],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99832577,0.00019221281,0.0004335204,0.0006142784,0.00014157312,0.00029263325],"domain_scores_gemma":[0.99923277,0.000006454489,0.00023578567,0.00037544445,0.00006373785,0.00008583691],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002576403,0.00039830396,0.0006440705,0.00015185516,0.00021192824,0.000094966956,0.0002222622,0.00038900526,0.00024336265],"category_scores_gemma":[0.000004224783,0.0003333484,0.00031906486,0.000118689386,0.00013414401,0.0000116755655,0.000013783163,0.00028853636,0.0000064147143],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000120593984,0.00014111938,0.0000052378896,0.0006247816,0.00020109759,0.0000082011275,0.00004409035,0.000027365879,0.051994137,0.000061735635,0.000048242786,0.9467234],"study_design_scores_gemma":[0.0008420908,0.0002184651,0.00001750139,0.0005836064,0.00008247689,0.000039865212,0.000019324207,0.000016023381,0.00688868,0.00014965744,0.99069643,0.00044587092],"about_ca_topic_score_codex":0.000017491866,"about_ca_topic_score_gemma":0.000004561924,"teacher_disagreement_score":0.9906482,"about_ca_system_score_codex":0.000022319073,"about_ca_system_score_gemma":0.00020523577,"threshold_uncertainty_score":0.99991184},"labels":[],"label_agreement":null},{"id":"W2890296921","doi":"10.1038/s41392-018-0022-9","title":"The intracellular signalosome of PD-L1 in cancer cells","year":2018,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":290,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Fundación Española para la Ciencia y la Tecnología; Universidad Pública de Navarra; Instituto de Salud Carlos III; Ministerio de Economía y Competitividad","keywords":"Intracellular; Cancer; Biology; Chemistry; Cell biology; Computational biology; Genetics","score_opus":0.04542014459269217,"score_gpt":0.32253754590274536,"score_spread":0.2771174013100532,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2890296921","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.001160994,0.9967057,0.0000366571,0.00018658671,0.00060621696,0.0011429755,0.000051720606,0.000025521025,0.00008361922],"genre_scores_gemma":[0.0012796004,0.9975415,0.0000331356,0.00007866143,0.0004227154,0.0001251353,0.000038767557,0.00005482028,0.00042569384],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99806494,0.00021930363,0.00076922047,0.00038220137,0.00026705788,0.0002972539],"domain_scores_gemma":[0.9991742,0.000111589645,0.0002848911,0.00026003853,0.00008786702,0.000081418424],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004912562,0.00037720005,0.0010962096,0.00022563442,0.00011463923,0.000023641578,0.000143321,0.000319789,0.0012117982],"category_scores_gemma":[0.0000027275867,0.0002268415,0.0004796241,0.0005578509,0.00042396286,0.000054043223,0.0000056876625,0.00041853767,0.0000057383854],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0015371913,0.00015367015,0.000005035927,0.0024287996,0.0007756828,0.0000068736654,0.00030036233,5.1819836e-7,0.016430166,0.00002203695,0.00026597976,0.97807366],"study_design_scores_gemma":[0.0016958471,0.0005530561,0.000020479463,0.0036930083,0.0002446477,0.000029432922,0.000059430604,0.000005735393,0.013486003,0.00006927241,0.9798928,0.0002503262],"about_ca_topic_score_codex":0.00015064025,"about_ca_topic_score_gemma":0.0000278457,"teacher_disagreement_score":0.9796268,"about_ca_system_score_codex":0.00009130037,"about_ca_system_score_gemma":0.00031848095,"threshold_uncertainty_score":0.9997012},"labels":[],"label_agreement":null},{"id":"W2897585779","doi":"10.1038/s41392-018-0030-9","title":"TdIF1: a putative oncogene in NSCLC tumor progression","year":2018,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Natural Science Foundation of Jiangxi Province; National Natural Science Foundation of China","keywords":"Biology; Cancer research; Cell cycle; Gene silencing; Oncogene; Cell growth; Cancer; Lung cancer; Adenocarcinoma; Downregulation and upregulation; Molecular biology; Gene; Genetics; Pathology; Medicine","score_opus":0.019155044242317655,"score_gpt":0.2961445424045646,"score_spread":0.27698949816224694,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2897585779","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.98987496,0.0038054732,0.0031279156,0.0010060865,0.0002983734,0.0007729818,0.000010537235,0.00010685679,0.0009968338],"genre_scores_gemma":[0.9976348,0.00041684337,0.0010461237,0.000438485,0.00028574993,0.000045699835,0.000029216231,0.000030709463,0.0000723251],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989433,0.00008327495,0.00021561918,0.00031847475,0.00021219748,0.00022709275],"domain_scores_gemma":[0.9995982,0.000012913074,0.000053227763,0.00011021107,0.00010333032,0.00012209953],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016175132,0.00016266215,0.00022307735,0.00018584958,0.00008079079,0.000012866122,0.000033979435,0.000092186456,0.0007128871],"category_scores_gemma":[0.0000073456454,0.00013461302,0.000069837035,0.00038916056,0.00018441508,0.00007591703,0.0000038110695,0.0002282872,0.000018559364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024092293,0.0002510333,0.00034454258,0.0000173021,0.00007463117,0.000055200246,0.0021784487,0.0000062547874,0.8874239,0.00006881023,0.0000620527,0.1071086],"study_design_scores_gemma":[0.0081587145,0.0028390426,0.005430415,0.00020045301,0.000031330703,0.00021488681,0.0003444461,0.0005832222,0.96983045,0.0006075073,0.011519482,0.00024006676],"about_ca_topic_score_codex":0.000029552435,"about_ca_topic_score_gemma":0.000013085571,"teacher_disagreement_score":0.106868535,"about_ca_system_score_codex":0.00006028332,"about_ca_system_score_gemma":0.00010654426,"threshold_uncertainty_score":0.7805614},"labels":[],"label_agreement":null},{"id":"W2935753526","doi":"10.1038/s41392-019-0042-0","title":"Signal-induced PARP1-Erk synergism mediates IEG expression","year":2019,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université de Montréal","funders":"National Institute on Drug Abuse; Efficacy and Mechanism Evaluation Programme","keywords":"MAPK/ERK pathway; PARP1; Cell biology; Mechanism (biology); Intracellular; Stimulation; Signal transduction; Immediate early gene; Biology; Phosphorylation; Neuroscience; Gene expression; Chemistry; Gene; Genetics; Polymerase","score_opus":0.09188745218005683,"score_gpt":0.35047668787206465,"score_spread":0.2585892356920078,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2935753526","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0005985477,0.9941701,0.00046002594,0.0002595408,0.0012926104,0.0022716944,0.000109258755,0.00031495493,0.00052325614],"genre_scores_gemma":[0.002819439,0.9929655,0.00026454258,0.00042129456,0.0015153023,0.00042368175,0.000613139,0.0002153366,0.0007617494],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99610317,0.0004683355,0.0010612373,0.0010771707,0.0007080492,0.0005820513],"domain_scores_gemma":[0.9981583,0.00023696886,0.00048224808,0.0005603725,0.00016893394,0.0003931868],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004242404,0.0009568494,0.0025009287,0.0005499021,0.00021326246,0.00006762131,0.00020606778,0.0009253409,0.0060373656],"category_scores_gemma":[0.000008309838,0.0007211367,0.00090246147,0.0005911014,0.00016431572,0.00021534842,0.000014408256,0.0011189063,0.00017900424],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00053540454,0.00029453856,0.0000058596634,0.0056154607,0.0008226634,0.0000331542,0.0004248388,0.0000029873372,0.03669033,0.00005779101,0.0012348227,0.95428216],"study_design_scores_gemma":[0.0036807896,0.00083829334,0.0000090819185,0.009220435,0.00060309883,0.00022393889,0.00006540229,0.000010911781,0.01983293,0.00024075517,0.96445495,0.0008193869],"about_ca_topic_score_codex":0.000015344758,"about_ca_topic_score_gemma":6.694255e-7,"teacher_disagreement_score":0.9632202,"about_ca_system_score_codex":0.0001679805,"about_ca_system_score_gemma":0.00047005992,"threshold_uncertainty_score":0.999524},"labels":[],"label_agreement":null},{"id":"W2950457484","doi":"10.1038/s41392-018-0034-5","title":"Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning","year":2019,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Compute Canada","keywords":"ERCC1; Carboplatin; Cisplatin; Bladder cancer; Oxaliplatin; Gene signature; Oncology; Cancer research; Medicine; Prostate cancer; Colorectal cancer; Internal medicine; Cancer; Biology; Chemotherapy; Gene; Gene expression; Genetics","score_opus":0.009670040946013501,"score_gpt":0.2343365067016757,"score_spread":0.22466646575566218,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2950457484","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9953303,0.0019097605,0.0010473969,0.00027764883,0.000757774,0.00038980602,0.00002161586,0.00004944788,0.0002162897],"genre_scores_gemma":[0.99358666,0.0017727001,0.0006414853,0.0007002082,0.0018591888,0.000026761005,0.00009920105,0.000043452794,0.0012703331],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99894154,0.00007771135,0.00017291687,0.00041657116,0.00015577085,0.0002354989],"domain_scores_gemma":[0.99959266,0.000011051986,0.0000584239,0.00015395207,0.000059468566,0.00012446161],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015716348,0.00020163185,0.00018726385,0.00007263202,0.000103879174,0.000028603119,0.00008426275,0.0001155958,0.00047021586],"category_scores_gemma":[0.000008120263,0.00016922105,0.000065929366,0.00014116846,0.000046573987,0.000008846617,0.0000087052995,0.00014280617,0.0000060042826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0035006192,0.00004883685,0.014869026,0.000010865001,0.00010618063,8.9655245e-8,0.00055313506,0.00013288225,0.97155595,0.000004870607,0.00034458784,0.008872984],"study_design_scores_gemma":[0.0039006858,0.0013218047,0.010779353,0.000027153505,0.00001401343,0.000020946316,0.00022731154,0.0002756759,0.6645053,0.000013004583,0.31857306,0.00034170374],"about_ca_topic_score_codex":0.000054523658,"about_ca_topic_score_gemma":0.000010178647,"teacher_disagreement_score":0.31822848,"about_ca_system_score_codex":0.000008696289,"about_ca_system_score_gemma":0.000044705772,"threshold_uncertainty_score":0.6900634},"labels":[],"label_agreement":null},{"id":"W2979119543","doi":"10.1038/s41392-019-0066-5","title":"Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders","year":2019,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University; Impact","funders":"Fundamental Research Funds for the Central Universities; Department of Science and Technology of Sichuan Province; Christian-Albrechts-Universität zu Kiel","keywords":"Association (psychology); Mood disorders; Allele frequency; Allele; Genetics; Medicine; Biology; Psychology; Psychiatry; Gene; Psychotherapist","score_opus":0.01661705673838137,"score_gpt":0.2147309603982736,"score_spread":0.19811390365989223,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2979119543","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99404746,0.00037520836,0.0007094095,0.0038392018,0.00010050323,0.00035755977,0.00006981396,0.000041936186,0.00045888545],"genre_scores_gemma":[0.99852103,0.0011144822,0.00006501292,0.00014082616,0.000045130306,0.000014689811,0.0000038708863,0.000015136577,0.00007982603],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99891376,0.0001548568,0.00015597802,0.00040326559,0.00019377336,0.0001783855],"domain_scores_gemma":[0.9989896,0.0007315104,0.000105319574,0.000084950334,0.000036333833,0.00005231485],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015499214,0.00018016943,0.00026244685,0.00009173534,0.00018030286,0.000033131277,0.000053537482,0.00007956762,0.00008824655],"category_scores_gemma":[0.000053402277,0.0001298627,0.000031848955,0.0001893174,0.00014371736,0.00023331672,0.0000072199787,0.0001445581,0.0000011295131],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018828954,0.000103328486,0.53334695,0.000041666437,0.0001966152,3.7803372e-7,0.0040784366,0.000005096666,0.45408398,0.0008976061,0.000009595304,0.007048045],"study_design_scores_gemma":[0.0025159712,0.0012461706,0.933617,0.00003152291,0.0000306275,0.000011677222,0.001301024,0.0000827676,0.05223178,0.0084427055,0.00019858895,0.00029017817],"about_ca_topic_score_codex":0.00010589422,"about_ca_topic_score_gemma":0.00013062642,"teacher_disagreement_score":0.4018522,"about_ca_system_score_codex":0.00001756228,"about_ca_system_score_gemma":0.000022611735,"threshold_uncertainty_score":0.52956474},"labels":[],"label_agreement":null},{"id":"W2992050936","doi":"10.1038/s41392-019-0091-4","title":"MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models","year":2019,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China; Chongqing Municipal Education Commission; National Natural Science Foundation of China","keywords":"Downregulation and upregulation; MAPK/ERK pathway; Neuroprotection; Signal transduction; Protein tyrosine phosphatase; Alzheimer's disease; Kinase; Amyloid precursor protein; Phosphatase; Biology; Protein kinase A; Cell biology; Long-term potentiation; Phosphorylation; Neuroscience; Internal medicine; Medicine; Biochemistry; Gene; Receptor; Disease","score_opus":0.05220915398323118,"score_gpt":0.3087245410883813,"score_spread":0.25651538710515015,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W2992050936","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.94547766,0.05251449,0.000032032218,0.0005365791,0.000058990914,0.0012109792,0.00004488439,0.000034913977,0.00008947385],"genre_scores_gemma":[0.98942655,0.0097615775,0.000056478173,0.00021603442,0.00010825869,0.000118397984,0.0002695811,0.000021768405,0.000021333606],"study_design_codex":"observational","study_design_gemma":"observational","domain_scores_codex":[0.99888617,0.00009571169,0.00017538111,0.00036195098,0.00024302963,0.00023775508],"domain_scores_gemma":[0.99946356,0.000023356,0.000034125354,0.00007870884,0.000073566494,0.00032671267],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101581136,0.00018270138,0.00021392436,0.00014762646,0.000078820536,0.000030683004,0.000023099055,0.00005882632,0.00038450724],"category_scores_gemma":[0.0000023162727,0.00014720451,0.000060998096,0.00012908432,0.000079232545,0.00037313259,0.000005333309,0.00011869406,0.000013858506],"study_design_candidate":"observational","study_design_consensus":"observational","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.039383914,0.009151139,0.4750659,0.00028987348,0.02865678,0.0009068752,0.011302183,0.0002865186,0.10163118,0.00065941224,0.00026091567,0.33240533],"study_design_scores_gemma":[0.06224864,0.006596789,0.78889275,0.0007695803,0.0020014425,0.0001814594,0.0027402232,0.04883802,0.0779619,0.007941268,0.00026157493,0.001566357],"about_ca_topic_score_codex":0.000068648005,"about_ca_topic_score_gemma":0.0000027645058,"teacher_disagreement_score":0.33083898,"about_ca_system_score_codex":0.0000184943,"about_ca_system_score_gemma":0.0000783275,"threshold_uncertainty_score":0.6002826},"labels":[],"label_agreement":null},{"id":"W3014732242","doi":"10.1038/s41392-020-0145-7","title":"NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease","year":2020,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"National Natural Science Foundation of China; Michael Smith Health Research BC","keywords":"Inflammasome; Disease; Alzheimer's disease; Medicine; Computational biology; Biology; Immunology; Pathology; Inflammation","score_opus":0.06325197781661109,"score_gpt":0.3137072060230861,"score_spread":0.25045522820647503,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3014732242","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0026063544,0.12639178,0.0018537677,0.85961473,0.0005763667,0.0064246906,0.0017557186,0.0004746813,0.00030188554],"genre_scores_gemma":[0.26797807,0.010209703,0.0015220016,0.69444966,0.010276509,0.0020977838,0.012094835,0.0005802381,0.0007911782],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99693644,0.00011848325,0.000449985,0.0009726391,0.0007626037,0.0007598637],"domain_scores_gemma":[0.9983031,0.00012342414,0.00014438442,0.00036792678,0.0002335694,0.0008275566],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009918111,0.00072469714,0.00079720037,0.00027910728,0.0003033888,0.000094112576,0.00016122933,0.00044404168,0.0017069463],"category_scores_gemma":[0.000013051254,0.0005891455,0.00064396416,0.0002799239,0.0002710033,0.00017216039,0.000012680589,0.001117362,0.00007988697],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.06839229,0.0048928745,0.002211412,0.0028681993,0.20735915,0.006075256,0.001848122,0.000028354258,0.021026347,0.0009068292,0.61766964,0.06672154],"study_design_scores_gemma":[0.01420131,0.003430367,0.0008679953,0.00016925973,0.003683428,0.00009881943,0.000054503078,0.000317205,0.0053138463,0.0070248717,0.9638512,0.000987209],"about_ca_topic_score_codex":0.00002349399,"about_ca_topic_score_gemma":3.4226315e-7,"teacher_disagreement_score":0.34618157,"about_ca_system_score_codex":0.000058492307,"about_ca_system_score_gemma":0.0006799751,"threshold_uncertainty_score":0.999656},"labels":[],"label_agreement":null},{"id":"W3035022428","doi":"10.1038/s41392-020-0189-8","title":"BARMR1-mediated sorafenib resistance is derived through stem-like property acquisition by activating integrin-FAK signaling pathways","year":2020,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"Hubei University; Hubei University of Medicine; National Natural Science Foundation of China","keywords":"Integrin; Signal transduction; Cancer research; Cell biology; Property (philosophy); Chemistry; Medicine; Biology; Computational biology; Receptor; Biochemistry; Philosophy","score_opus":0.04510868499739957,"score_gpt":0.2628148858388217,"score_spread":0.21770620084142212,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3035022428","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.08152654,0.017307777,0.014064585,0.87801176,0.00083798944,0.0052198237,0.0008820511,0.0010646251,0.0010848251],"genre_scores_gemma":[0.2017248,0.01030242,0.0028916565,0.7652599,0.0040749796,0.0004378024,0.0063286,0.0006323059,0.008347523],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9952568,0.0005487612,0.0008021302,0.0013309239,0.0012918996,0.0007694884],"domain_scores_gemma":[0.99840695,0.00018363839,0.00030810427,0.00040325394,0.00041893643,0.00027912698],"candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002412959,0.0007929353,0.0009873075,0.00023316283,0.0004080681,0.00014904932,0.00025032574,0.0009163277,0.0034539101],"category_scores_gemma":[0.000022421882,0.0005876901,0.00036217863,0.00068366074,0.0002893766,0.0002860257,0.000029197217,0.0033516018,0.00006464978],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0016536459,0.000102085636,0.0000111087775,0.0005016618,0.00036442987,0.00026038,0.001983579,0.0000014578902,0.75761455,0.0000014670801,0.2339649,0.0035407308],"study_design_scores_gemma":[0.0029628496,0.00058357575,0.000013470519,0.00042006432,0.00006704646,0.000034007062,0.0005054379,0.00014342184,0.46833396,0.00013428478,0.5262238,0.00057808665],"about_ca_topic_score_codex":0.00005135557,"about_ca_topic_score_gemma":0.0000015301866,"teacher_disagreement_score":0.2922589,"about_ca_system_score_codex":0.00020441924,"about_ca_system_score_gemma":0.00031419637,"threshold_uncertainty_score":0.99965745},"labels":[],"label_agreement":null},{"id":"W3035408975","doi":"10.1038/s41392-020-0187-x","title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects","year":2020,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":1132,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McMaster University","funders":"","keywords":"Sorafenib; Hepatocellular carcinoma; Resistance (ecology); Medicine; Oncology; Bioinformatics; Internal medicine; Cancer research; Computational biology; Biology","score_opus":0.05311660016790334,"score_gpt":0.2674391736520976,"score_spread":0.21432257348419423,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3035408975","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0031593905,0.9937254,0.0002792071,0.00076883,0.000090183785,0.001699863,0.000028797285,0.000038214068,0.00021006676],"genre_scores_gemma":[0.39584342,0.60374653,0.00011718209,0.000039647468,0.0000546272,0.0000950509,0.00003142935,0.000043738648,0.00002836546],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9977271,0.0004676162,0.00063639804,0.00054384687,0.00030989156,0.000315177],"domain_scores_gemma":[0.9990881,0.0002424416,0.00017637164,0.0002544208,0.0000596366,0.0001790383],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004019548,0.00048615254,0.0014389807,0.00017313242,0.00014920847,0.00003574887,0.00011137262,0.00031890124,0.00020172764],"category_scores_gemma":[0.00001006298,0.0003014674,0.000407952,0.00048363814,0.00040607556,0.000035717832,0.000012180034,0.00049011066,0.0000032686569],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0011311352,0.0002758131,0.0014062892,0.0049659563,0.0010321314,0.0002999823,0.0009018878,2.1415994e-8,0.0008500286,0.091413945,0.000010299386,0.8977125],"study_design_scores_gemma":[0.008284951,0.0026788048,0.00051725266,0.005433303,0.0037876386,0.0003450739,0.00043139103,0.00050036196,0.013380417,0.073840626,0.8893759,0.0014242558],"about_ca_topic_score_codex":0.000012084752,"about_ca_topic_score_gemma":0.0000060799366,"teacher_disagreement_score":0.8962883,"about_ca_system_score_codex":0.000051048068,"about_ca_system_score_gemma":0.00020357783,"threshold_uncertainty_score":0.99994373},"labels":[],"label_agreement":null},{"id":"W3043486525","doi":"10.1038/s41392-020-00239-y","title":"Mitochondria hyperactivity contributes to social behavioral impairments","year":2020,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Diet and metabolism studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Government of Canada","keywords":"Mitochondrion; Psychology; Biology; Cell biology","score_opus":0.03910334667232747,"score_gpt":0.30159566006898403,"score_spread":0.2624923133966566,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3043486525","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.13388546,0.0028428824,0.00026788228,0.8585733,0.0021856946,0.0014858665,0.00030013596,0.00021654616,0.00024218335],"genre_scores_gemma":[0.25500277,0.001856656,0.00039381316,0.72741014,0.012113086,0.00026606754,0.00083598914,0.00014560735,0.0019758637],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99828935,0.00010892683,0.00030158725,0.00053282373,0.00036455024,0.00040275767],"domain_scores_gemma":[0.9994878,0.000029533603,0.00008468711,0.00011460575,0.00014485068,0.00013850145],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000066227614,0.00042657333,0.00086776534,0.0001817821,0.00026979062,0.000052785002,0.00007321093,0.0004049006,0.0004822784],"category_scores_gemma":[0.0000064741334,0.00036253754,0.00030340132,0.00026055795,0.00012280975,0.000091035276,0.000012983852,0.0011172005,0.000032133135],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0017864644,0.000327388,0.0007051624,0.0001093578,0.0009650971,0.00025352094,0.0019027747,1.2865584e-7,0.11673695,0.000009779822,0.8575564,0.019646954],"study_design_scores_gemma":[0.00361726,0.000748459,0.008352516,0.00004023328,0.00041176318,0.00001653941,0.00016830197,0.0000012919337,0.0045097047,0.00016907163,0.9816033,0.00036150904],"about_ca_topic_score_codex":0.000042265834,"about_ca_topic_score_gemma":0.0000021131395,"teacher_disagreement_score":0.1311632,"about_ca_system_score_codex":0.00004465268,"about_ca_system_score_gemma":0.000082422994,"threshold_uncertainty_score":0.99988264},"labels":[],"label_agreement":null},{"id":"W3047389571","doi":"10.1038/s41392-020-0179-x","title":"The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination","year":2020,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Liver physiology and pathology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Tsinghua-Berkeley Shenzhen institute; University of Toronto; National Key Research and Development Program of China; Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents; Institut Gustave-Roussy; Southeast University; Zhejiang University; Sichuan University; Francis Crick Institute; China Postdoctoral Science Foundation; National Natural Science Foundation of China; University of Science and Technology of China","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Cancer; Cancer research; Medicine; Liver cancer; Signal transduction; Biology; Internal medicine; Cell biology","score_opus":0.03350429200011743,"score_gpt":0.27446212184339364,"score_spread":0.2409578298432762,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3047389571","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.974328,0.01222139,0.0008856839,0.01122332,0.00047812244,0.00049931015,0.00003082495,0.00010486916,0.0002284818],"genre_scores_gemma":[0.9881866,0.009086719,0.000077682336,0.001890952,0.0004979256,0.000044944412,0.000031103125,0.000014753532,0.00016932581],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9991319,0.00014556237,0.00015917387,0.00025695513,0.00013356899,0.00017281479],"domain_scores_gemma":[0.9995909,0.00007001314,0.000048307716,0.00009198668,0.000088597524,0.000110218905],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00010947736,0.00013545387,0.00018432777,0.000032315445,0.00024823743,0.000014812592,0.00006127211,0.00011394599,0.0026767624],"category_scores_gemma":[0.000008319423,0.00008775812,0.00008046419,0.00012511305,0.0000777017,0.00009449265,0.000005684988,0.00023673459,0.000017403303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0055618254,0.00022015175,0.006284036,0.00009621349,0.0006383349,0.000045044704,0.0058298293,0.0000618388,0.86105144,0.0013425054,0.0017362359,0.11713255],"study_design_scores_gemma":[0.007726356,0.003264449,0.20070723,0.000024823126,0.0002592487,0.000099281475,0.0009851361,0.00072758156,0.6900895,0.0016041101,0.0940782,0.0004340718],"about_ca_topic_score_codex":0.00003916693,"about_ca_topic_score_gemma":0.000011639882,"teacher_disagreement_score":0.1944232,"about_ca_system_score_codex":0.000013718617,"about_ca_system_score_gemma":0.00004770185,"threshold_uncertainty_score":0.9982349},"labels":[],"label_agreement":null},{"id":"W3112301923","doi":"10.1038/s41392-020-00360-y","title":"Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes","year":2020,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Tongji University; National Natural Science Foundation of China","keywords":"Fulminant; Myocarditis; Medicine; Etiology; Pathophysiology; Intensive care medicine; Cytokine storm; Clinical trial; Acute myocarditis; Mechanism (biology); Cardiology; Bioinformatics; Internal medicine; Pathology; Disease; Coronavirus disease 2019 (COVID-19)","score_opus":0.08089916316962174,"score_gpt":0.38646687018771975,"score_spread":0.305567707018098,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3112301923","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00040919002,0.99503803,0.00007158978,0.001992101,0.00021071697,0.0019873206,0.00017868598,0.00006010572,0.000052283754],"genre_scores_gemma":[0.00009280177,0.99743557,0.00014887692,0.001312936,0.00013608205,0.00030634092,0.0004013197,0.000041048337,0.00012504264],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9982689,0.00035388625,0.0004433485,0.0005553034,0.00013303381,0.0002455537],"domain_scores_gemma":[0.99930894,0.00010095231,0.00009037573,0.00020065537,0.00008645598,0.00021259837],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007497439,0.00040457412,0.0022136,0.0001873822,0.00013614011,0.000018666615,0.000058382466,0.00026615206,0.00074611616],"category_scores_gemma":[0.0000132555615,0.00027496956,0.00038191886,0.0003115771,0.00015189534,0.000049413546,0.000017937571,0.00049117283,0.00007310363],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00010095906,0.00008508353,0.000042773627,0.0026887713,0.0021113951,0.000039522893,0.00007732288,1.9301378e-8,0.00018420827,0.000010230751,0.00040122337,0.99425846],"study_design_scores_gemma":[0.0011581663,0.0014778251,0.0010406256,0.005779078,0.001028991,0.00022556711,0.000030160209,5.188552e-7,0.000024957108,0.00003483217,0.9889722,0.0002271098],"about_ca_topic_score_codex":0.0000807477,"about_ca_topic_score_gemma":0.0000011460295,"teacher_disagreement_score":0.99403137,"about_ca_system_score_codex":0.000046836878,"about_ca_system_score_gemma":0.0001066893,"threshold_uncertainty_score":0.99997026},"labels":[],"label_agreement":null},{"id":"W3122124144","doi":"10.1038/s41392-020-00379-1","title":"Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5","year":2021,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"International Cooperation and Exchange Programme; National Natural Science Foundation of China","keywords":"Psoriasis; Pathogenesis; Lysophosphatidic acid; Dermatology; Keratinocyte; Medicine; Immunology; Biology; Genetics; Internal medicine; Cell culture","score_opus":0.01673874889177419,"score_gpt":0.2330772937412701,"score_spread":0.2163385448494959,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3122124144","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.55144596,0.3765051,0.005894414,0.062012997,0.0024307074,0.0008867502,0.0006145645,0.00006694447,0.0001425632],"genre_scores_gemma":[0.7124456,0.12201197,0.002164191,0.14432992,0.012611076,0.00016823344,0.0054416195,0.00026134888,0.0005660563],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99795735,0.00033136067,0.00045863265,0.00059049216,0.00033183425,0.00033035083],"domain_scores_gemma":[0.9990886,0.00007217829,0.00028608745,0.00033920477,0.00016995404,0.000043993157],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00024742758,0.0004190917,0.0004801005,0.00004425438,0.00024745165,0.00006152944,0.00023144737,0.00062575185,0.00036359238],"category_scores_gemma":[0.00003283725,0.00031044308,0.00027919826,0.00020510066,0.0001908769,0.000014808989,0.000022548382,0.00049666513,8.236097e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000093389855,0.000033930002,0.000042216594,0.000063633255,0.00039156427,0.0000036205763,0.000609813,0.000010725605,0.94924533,0.0000071235877,0.041946717,0.007551949],"study_design_scores_gemma":[0.0006327038,0.000102052836,0.0000448857,0.00002943979,0.000055312026,0.000009842698,0.00025937732,0.0000069353987,0.7310706,0.00008132788,0.26744905,0.0002584945],"about_ca_topic_score_codex":0.000054087137,"about_ca_topic_score_gemma":0.0000016435876,"teacher_disagreement_score":0.25449315,"about_ca_system_score_codex":0.000007146328,"about_ca_system_score_gemma":0.00010437563,"threshold_uncertainty_score":0.9999348},"labels":[],"label_agreement":null},{"id":"W3125247195","doi":"10.1038/s41392-021-00471-0","title":"Cell-type-specific memory consolidation driven by translational control","year":2021,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Consolidation (business); Memory consolidation; Computational biology; Computer science; Biology; Neuroscience; Business","score_opus":0.010289549540377979,"score_gpt":0.2179619746254913,"score_spread":0.20767242508511333,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3125247195","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.87869424,0.020833218,0.098660566,0.0005343869,0.0004715463,0.00024546174,0.000075612064,0.000030242232,0.00045474668],"genre_scores_gemma":[0.99361265,0.0041120737,0.00067220564,0.00031028214,0.0002379718,0.000010114511,0.00063809304,0.000020497579,0.0003861079],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99912167,0.00010765302,0.00017675462,0.00031393892,0.000129965,0.00015002872],"domain_scores_gemma":[0.99965066,0.000010823997,0.00004213439,0.000097033226,0.00012580691,0.000073539486],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000099672216,0.00013803843,0.00012785445,0.000027233074,0.0001310299,0.00003466957,0.000045702804,0.00013377637,0.002326138],"category_scores_gemma":[0.0000017689547,0.00013718299,0.000079483856,0.00008725549,0.00004640369,0.000009526937,0.0000023294122,0.000090182475,0.000004992943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022029558,0.00007539297,0.000072839626,0.0000046361115,0.00005445253,0.0000013615979,0.00010820357,0.0002840919,0.9938931,0.000092480506,0.0010301662,0.0041629868],"study_design_scores_gemma":[0.0019755182,0.00019047076,0.00008921716,0.0000036688414,0.000008981216,0.000013601904,0.00013695926,0.00017570578,0.9504149,0.00018317417,0.046640083,0.00016770717],"about_ca_topic_score_codex":0.000002052609,"about_ca_topic_score_gemma":8.4036725e-7,"teacher_disagreement_score":0.11491843,"about_ca_system_score_codex":0.000004193846,"about_ca_system_score_gemma":0.000052379313,"threshold_uncertainty_score":0.9985859},"labels":[],"label_agreement":null},{"id":"W3128681620","doi":"10.1038/s41392-020-00410-5","title":"Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Chongqing Medical University","keywords":"Cystathionine beta synthase; Myeloid leukemia; Apoptosis; K562 cells; Cancer research; Cell growth; Leukemia; Bone marrow; Chronic myelogenous leukemia; Biology; Myeloid; Chemistry; Molecular biology; Immunology; Biochemistry; Enzyme","score_opus":0.015846425551478107,"score_gpt":0.24925571331278457,"score_spread":0.23340928776130646,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3128681620","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99262184,0.005721964,0.0001921576,0.00064677896,0.0000621053,0.0005551219,0.000017004546,0.00003844005,0.00014461456],"genre_scores_gemma":[0.99268955,0.0060075945,0.00069155573,0.00006420746,0.00011469039,0.000057436046,0.0001898217,0.00002256594,0.00016255229],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987993,0.00010175263,0.00034968977,0.00036049864,0.00020116114,0.00018759136],"domain_scores_gemma":[0.9995597,0.000030958447,0.000089859794,0.00011704029,0.00010982967,0.00009258373],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563524,0.00018662309,0.0003123124,0.00016548595,0.0000698298,0.000018814904,0.000017112356,0.00012772743,0.0004278795],"category_scores_gemma":[0.000010546623,0.00016834855,0.000057433015,0.00032206622,0.000099412515,0.0001717609,0.00000544935,0.00019134152,0.000001543914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004907323,0.00024468324,0.0005549446,0.00020241125,0.000061292434,0.000015795791,0.0015048217,0.000038936298,0.9754901,0.000028840983,0.000014729274,0.021352721],"study_design_scores_gemma":[0.007686269,0.0008083283,0.0024621533,0.00020275993,0.000046548943,0.00007780414,0.0003507791,0.0006044744,0.9872781,0.00018363618,0.0001611808,0.00013793535],"about_ca_topic_score_codex":0.00006237951,"about_ca_topic_score_gemma":0.000015307634,"teacher_disagreement_score":0.021214785,"about_ca_system_score_codex":0.0004165989,"about_ca_system_score_gemma":0.0006451341,"threshold_uncertainty_score":0.68650544},"labels":[],"label_agreement":null},{"id":"W3132116659","doi":"10.1038/s41392-021-00463-0","title":"PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus","year":2021,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Cohesin; Nucleus; Biology; Cell biology; Genetics; DNA","score_opus":0.028120718709838396,"score_gpt":0.24591813592213688,"score_spread":0.21779741721229848,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3132116659","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.7381625,0.007383519,0.0002525686,0.2518746,0.0005768459,0.001319369,0.00005061189,0.00008394972,0.00029599166],"genre_scores_gemma":[0.8037411,0.0052366788,0.0002072457,0.1876038,0.0018320889,0.00011334184,0.0008140479,0.00010152574,0.00035016934],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9979901,0.00037199832,0.0004143363,0.000553707,0.00035949875,0.00031037824],"domain_scores_gemma":[0.9992418,0.000105735984,0.00014561799,0.0003657884,0.0001000506,0.000040949817],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003729776,0.00038106562,0.0004912585,0.0001742438,0.00013467624,0.0000823458,0.000110791596,0.00042668532,0.0022649472],"category_scores_gemma":[0.0000023344153,0.0002446897,0.00020836493,0.00036061325,0.00025051605,0.00012235776,0.0000039115994,0.0013302508,0.0000035609235],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0297072,0.0007330413,0.0015820785,0.0006012142,0.002017571,0.0006139246,0.008784731,0.00001320808,0.83181614,0.00000644985,0.034696244,0.08942818],"study_design_scores_gemma":[0.007179088,0.0016805246,0.0250647,0.0003687741,0.00020337255,0.001110013,0.0015426656,0.00005358325,0.066331394,0.00016941987,0.89565635,0.00064010837],"about_ca_topic_score_codex":0.00032246375,"about_ca_topic_score_gemma":0.00007077228,"teacher_disagreement_score":0.8609601,"about_ca_system_score_codex":0.0001622188,"about_ca_system_score_gemma":0.00014291766,"threshold_uncertainty_score":0.9986471},"labels":[],"label_agreement":null},{"id":"W3142080073","doi":"10.1038/s41392-021-00507-5","title":"Pyroptosis: mechanisms and diseases","year":2021,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2308,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"Project 211; Higher Education Discipline Innovation Project; National Natural Science Foundation of China","keywords":"Pyroptosis; Medicine; Immunology; Inflammasome; Inflammation","score_opus":0.016770219427606488,"score_gpt":0.26870901036315387,"score_spread":0.2519387909355474,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3142080073","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0003070452,0.99841774,0.00065255724,0.000029173514,0.00017647397,0.0002940682,0.00005470728,0.00001750627,0.000050730032],"genre_scores_gemma":[0.00053966994,0.99791104,0.000099657365,0.00009266848,0.00015667337,0.000070474394,0.0008715385,0.000045291737,0.00021300017],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9989192,0.00013609024,0.00023976728,0.0004350544,0.000085240994,0.00018467713],"domain_scores_gemma":[0.99962837,0.0000071106642,0.000077021046,0.00016983006,0.000041972457,0.00007567386],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006526936,0.00031274327,0.00054352457,0.00006620964,0.000121529694,0.000046596604,0.00007323386,0.0002691226,0.00020855328],"category_scores_gemma":[0.000004069535,0.0002612272,0.00026826904,0.000100177436,0.00008041267,0.000005499046,0.000016578642,0.0001342731,0.000002366654],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000033709195,0.000055099506,0.0000014199342,0.0006689975,0.0004649835,0.0000026898363,0.000038324295,4.947605e-7,0.008028551,0.00020443638,0.00013227986,0.990369],"study_design_scores_gemma":[0.00045672126,0.00021843477,0.0000042048027,0.00039808196,0.00019354236,0.000032847012,0.00009338863,7.466947e-7,0.004115161,0.00013774575,0.9940013,0.00034777392],"about_ca_topic_score_codex":0.0000030583456,"about_ca_topic_score_gemma":9.1902433e-7,"teacher_disagreement_score":0.99386907,"about_ca_system_score_codex":0.000004357015,"about_ca_system_score_gemma":0.000087264125,"threshold_uncertainty_score":0.99998397},"labels":[],"label_agreement":null},{"id":"W3160668788","doi":"10.1038/s41392-021-00569-5","title":"Targeting circular RNAs as a therapeutic approach: current strategies and challenges","year":2021,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":561,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital","funders":"Canadian Institutes of Health Research","keywords":"Circular RNA; Gene knockdown; Computational biology; Biology; RNA interference; Microvesicles; Function (biology); Exosome; Bioinformatics; microRNA; RNA; Cell biology; Gene; Genetics","score_opus":0.08003431253310524,"score_gpt":0.321686253947653,"score_spread":0.24165194141454777,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3160668788","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00023114518,0.9969308,0.0017153455,0.000033975855,0.0002561095,0.00062459,0.000034692715,0.000039844814,0.00013351903],"genre_scores_gemma":[0.004493141,0.99380654,0.00009189415,0.000037803897,0.00056029466,0.00015080649,0.0007520013,0.000091334994,0.000016168373],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9976745,0.00045552442,0.00040114543,0.0009232612,0.00022175405,0.00032379158],"domain_scores_gemma":[0.999253,0.000021178408,0.00016749966,0.00031802917,0.00008335686,0.00015698384],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00023586398,0.00056701415,0.0008494873,0.00011085025,0.00017108815,0.00016474313,0.00016875273,0.0003753547,0.00009551996],"category_scores_gemma":[0.000011201743,0.0004935506,0.0004173646,0.00013886728,0.00019552709,0.000018148377,0.00003231318,0.00033596772,0.0000023051803],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000025004252,0.00017012806,0.0000012359095,0.0040838216,0.00076144835,0.0000066298744,0.00014622282,0.0000062742565,0.0029501258,0.0007156838,0.000016671816,0.99111676],"study_design_scores_gemma":[0.00048197818,0.00016556635,0.0000049229957,0.00069219095,0.00030603033,0.00017570576,0.0007004122,0.0000065658987,0.00035184485,0.00030645184,0.99622345,0.0005848518],"about_ca_topic_score_codex":0.0000044268077,"about_ca_topic_score_gemma":5.3329387e-7,"teacher_disagreement_score":0.9962068,"about_ca_system_score_codex":0.00001551423,"about_ca_system_score_gemma":0.00031867708,"threshold_uncertainty_score":0.9997516},"labels":[],"label_agreement":null},{"id":"W3160707791","doi":"10.1038/s41392-021-00617-0","title":"Cellular tropism and antigenicity of mink-derived SARS-CoV-2 variants","year":2021,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Canada","funders":"Chinese Academy of Sciences; Tsinghua University; Institute of Microbiology, Chinese Academy of Sciences; National Natural Science Foundation of China; Peking University; Bill and Melinda Gates Foundation","keywords":"Antigenicity; Mink; Tropism; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Biology; 2019-20 coronavirus outbreak; Computational biology; Medicine; Immunology; Virus; Pathology; Antibody; Infectious disease (medical specialty)","score_opus":0.051184018003857405,"score_gpt":0.30192057748689183,"score_spread":0.2507365594830344,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3160707791","genre_codex":"empirical","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9398606,0.016324198,0.0015557851,0.040572684,0.00043504345,0.00082403625,0.00008371077,0.000083967905,0.00026001522],"genre_scores_gemma":[0.37673435,0.0025151963,0.00047624976,0.61761594,0.0021456317,0.00004307738,0.0002102093,0.0001395205,0.00011983399],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.997375,0.0002814156,0.00050122524,0.0007516604,0.00062116684,0.0004695067],"domain_scores_gemma":[0.9990975,0.00008352052,0.00014821345,0.00036642392,0.00026093682,0.000043405147],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00024091145,0.00045646922,0.0009210837,0.00035371043,0.00013054383,0.000052045925,0.00012850833,0.00083712576,0.00018481139],"category_scores_gemma":[0.000013960763,0.00040092482,0.00029456321,0.00035973437,0.0003719662,0.00010182042,0.000017744122,0.0013811004,0.0000052956398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006284967,0.00015315715,0.00036064032,0.00049018575,0.00063538604,0.00043409358,0.00057845726,4.5900684e-8,0.98512447,0.00000965612,0.007322728,0.0042626914],"study_design_scores_gemma":[0.0027463096,0.00044505007,0.00057840376,0.00012988308,0.000103036786,0.000112447444,0.00005518599,0.000036472047,0.7211969,0.00018617851,0.27413476,0.00027537532],"about_ca_topic_score_codex":0.00021756614,"about_ca_topic_score_gemma":0.0000058756564,"teacher_disagreement_score":0.57704324,"about_ca_system_score_codex":0.000037134792,"about_ca_system_score_gemma":0.0002728414,"threshold_uncertainty_score":0.99984425},"labels":[],"label_agreement":null},{"id":"W3178278608","doi":"10.1038/s41392-021-00681-6","title":"Catch-as-catch-can: mRNA vaccination boosts immune responses to SARS-CoV-2 variants","year":2021,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences North","funders":"","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Vaccination; Immune system; Biology; Virology; Sars virus; Messenger RNA; Immunology; Computational biology; Medicine; Genetics; Gene; Pathology; Infectious disease (medical specialty)","score_opus":0.050406701222012386,"score_gpt":0.3339923691617706,"score_spread":0.2835856679397582,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3178278608","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.4833555,0.010846752,0.00063682284,0.49943843,0.0015467213,0.0024645864,0.00018049643,0.00034341862,0.001187256],"genre_scores_gemma":[0.13655797,0.00095480785,0.00020204014,0.8572631,0.0030832076,0.00024326224,0.00036083529,0.00020041045,0.0011343814],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.995521,0.00055834523,0.0007348994,0.0011997796,0.001148542,0.00083740207],"domain_scores_gemma":[0.99821013,0.00021451183,0.00017307303,0.00070064794,0.0006087536,0.00009290625],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006188374,0.0007212077,0.0010028995,0.000938434,0.00031211798,0.00019388084,0.00029848667,0.0010933764,0.00061713724],"category_scores_gemma":[0.00008785625,0.0006665905,0.0004128148,0.0010298216,0.00010890026,0.00019149185,0.000032752465,0.0021940614,0.000129267],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037838742,0.00025118983,0.00020465141,0.00026623445,0.00068773894,0.0009679171,0.0016208999,2.8410844e-7,0.91757435,0.000022373728,0.05583943,0.018781083],"study_design_scores_gemma":[0.002561514,0.00077466713,0.0014817523,0.00016042384,0.00008391232,0.00030848364,0.000105528765,0.000011622615,0.47890103,0.00028744046,0.51487786,0.00044575502],"about_ca_topic_score_codex":0.0007434923,"about_ca_topic_score_gemma":0.000032450273,"teacher_disagreement_score":0.45903844,"about_ca_system_score_codex":0.00024849788,"about_ca_system_score_gemma":0.0009001831,"threshold_uncertainty_score":0.99957854},"labels":[],"label_agreement":null},{"id":"W3182774911","doi":"10.1038/s41392-021-00679-0","title":"The signal pathways and treatment of cytokine storm in COVID-19","year":2021,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":608,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis; Servier; National Natural Science Foundation of China","keywords":"Cytokine storm; Immunology; Cytokine; Medicine; Cytokine release syndrome; Immune system; Neutrophilia; Disease; Population; Macrophage activation syndrome; Proinflammatory cytokine; ARDS; Pathogenesis; Inflammation; Infectious disease (medical specialty); Immunotherapy; Lung; Pathology; Coronavirus disease 2019 (COVID-19); Internal medicine; Arthritis","score_opus":0.14349360555717094,"score_gpt":0.4293561333629024,"score_spread":0.28586252780573146,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3182774911","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.00057405187,0.99630713,0.00014578609,0.001370268,0.00008504786,0.0013812009,0.000091556496,0.0000271177,0.000017817916],"genre_scores_gemma":[0.003931444,0.99522454,0.00003797694,0.00016494998,0.00020599892,0.0002028007,0.00008556978,0.00003291837,0.000113796],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9975756,0.00046180043,0.0007370654,0.0005212814,0.0003883853,0.00031586224],"domain_scores_gemma":[0.99584395,0.0033247028,0.00017030134,0.00024949483,0.000102556696,0.0003090053],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00066477613,0.0003859857,0.0017452233,0.00021411828,0.0001936799,0.000029285859,0.00007794844,0.0002275796,0.00031355413],"category_scores_gemma":[0.00039747334,0.00021688486,0.0004328184,0.00045810023,0.00045694868,0.000042656033,0.00001661773,0.0003803578,0.0000013449587],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00044530962,0.00037721178,0.00007265886,0.0030517224,0.000694434,0.000064793356,0.0006028954,0.0000025559707,0.00015896471,0.00011282976,0.000022568045,0.99439406],"study_design_scores_gemma":[0.0033268128,0.0019309643,0.00009604899,0.0016595443,0.00026200677,0.000019619934,0.00017613065,0.00001322763,0.00008467244,0.0001482301,0.9920971,0.00018566767],"about_ca_topic_score_codex":0.00017969953,"about_ca_topic_score_gemma":0.00007563313,"teacher_disagreement_score":0.9942084,"about_ca_system_score_codex":0.00027829758,"about_ca_system_score_gemma":0.0011158858,"threshold_uncertainty_score":0.88443077},"labels":[],"label_agreement":null},{"id":"W3183386301","doi":"10.1038/s41392-021-00704-2","title":"N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding","year":2021,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Biotechnology Research Institute","funders":"Beijing Municipal Administration of Hospitals","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Virology; Mutation; Transmission (telecommunications); Sars virus; Receptor; Betacoronavirus; Biology; Molecular biology; Medicine; Genetics; Pathology; Gene; Disease","score_opus":0.052501297071266224,"score_gpt":0.3420590178349025,"score_spread":0.2895577207636363,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3183386301","genre_codex":"empirical","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.93347913,0.0062650237,0.0067571225,0.050875895,0.0006644907,0.0012682884,0.0002087318,0.00014068375,0.00034060737],"genre_scores_gemma":[0.20834386,0.0014304767,0.0013486819,0.78181493,0.0036583906,0.00021023447,0.001539176,0.0003137777,0.001340445],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9968852,0.00022197503,0.00069721654,0.0007941202,0.0008561581,0.000545327],"domain_scores_gemma":[0.99899846,0.00013450407,0.00016777693,0.00024132377,0.00039313742,0.000064777094],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003947207,0.00047542408,0.00078153104,0.00053245557,0.00020682796,0.00011496664,0.00014857628,0.0007271497,0.00051960297],"category_scores_gemma":[0.000020010635,0.0004265664,0.0003336048,0.0006988838,0.0001783163,0.00019148446,0.000009504956,0.0012074368,0.000032329677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010170483,0.00011335201,0.00010252983,0.000480056,0.00025268085,0.00006749141,0.0015087323,7.2796234e-7,0.93191636,0.0000014211139,0.058306884,0.006232733],"study_design_scores_gemma":[0.0012195555,0.00039035268,0.000033439723,0.00024627562,0.00003250064,0.000036959977,0.000110923145,0.000010369309,0.54160404,0.000012243423,0.45608437,0.00021898364],"about_ca_topic_score_codex":0.000100093224,"about_ca_topic_score_gemma":0.0000060925154,"teacher_disagreement_score":0.73093903,"about_ca_system_score_codex":0.00013197979,"about_ca_system_score_gemma":0.0002712357,"threshold_uncertainty_score":0.9998186},"labels":[],"label_agreement":null},{"id":"W3206218751","doi":"10.1038/s41392-021-00765-3","title":"Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src","year":2021,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"National Key Research and Development Program of China; Higher Education Discipline Innovation Project; National Natural Science Foundation of China","keywords":"Senescence; Mesenchymal stem cell; Angiogenesis; Cell biology; Stem cell; Biology; Oxidative stress; Endothelial stem cell; Cancer research; In vitro; Biochemistry","score_opus":0.01431841512841141,"score_gpt":0.2215373473830019,"score_spread":0.20721893225459048,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3206218751","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.986051,0.0055766986,0.0076408796,0.00007539281,0.0001660174,0.0003307854,0.00009348208,0.000018992221,0.000046716326],"genre_scores_gemma":[0.9970963,0.0010748773,0.0012141531,0.000035642835,0.0001272227,0.000019408404,0.0001917206,0.000037723134,0.0002029599],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9981547,0.00036781782,0.000429657,0.00056621333,0.00020162687,0.0002799576],"domain_scores_gemma":[0.99923706,0.000025307818,0.00016775912,0.00028210465,0.00016086863,0.00012692588],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00019310892,0.00026497702,0.0002570662,0.00008093973,0.00008117886,0.000025066229,0.00012896131,0.00021515372,0.00015140777],"category_scores_gemma":[0.0000047333406,0.00028002975,0.00014029694,0.00020906179,0.00014358036,0.000020750422,0.000019834148,0.00015945034,0.000002450197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005231981,0.0003566229,0.00045245976,0.000061365645,0.00006708401,0.000022495,0.00061043643,0.00031218186,0.99139786,0.000029041928,0.000004341722,0.0061629093],"study_design_scores_gemma":[0.001964632,0.00023771737,0.0023565895,0.00003884879,0.00002236622,0.0000114705335,0.00061849714,0.0003627443,0.99371135,0.00020084906,0.00018581188,0.00028914952],"about_ca_topic_score_codex":0.000025986175,"about_ca_topic_score_gemma":0.000024063405,"teacher_disagreement_score":0.011045257,"about_ca_system_score_codex":0.000016467267,"about_ca_system_score_gemma":0.00011519575,"threshold_uncertainty_score":0.9999652},"labels":[],"label_agreement":null},{"id":"W3213709497","doi":"10.1038/s41392-021-00779-x","title":"Roles and mechanisms of exosomal non-coding RNAs in human health and diseases","year":2021,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":397,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Aging","funders":"Fundamental Research Funds for the Central Universities; Central South University; National Natural Science Foundation of China","keywords":"Microvesicles; microRNA; Exosome; Biology; Computational biology; Circular RNA; Biomarker; Diagnostic biomarker; Long non-coding RNA; Non-coding RNA; Bioinformatics; RNA; Gene; Genetics","score_opus":0.022920444520799763,"score_gpt":0.30769122175554026,"score_spread":0.2847707772347405,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W3213709497","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.007579722,0.9895207,0.00236448,0.000024354043,0.000049505976,0.00036771092,0.00007769449,0.000006916715,0.000008877536],"genre_scores_gemma":[0.059456553,0.93975574,0.00018511941,0.000043898624,0.000086730775,0.000027912456,0.00038543367,0.000034018598,0.000024606472],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9986996,0.00020823242,0.00036843034,0.00044811657,0.000098827586,0.00017678445],"domain_scores_gemma":[0.99949473,0.000012448352,0.00015085663,0.00015060179,0.000025605546,0.00016578528],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013738638,0.00026259382,0.0006583648,0.0001029759,0.00008330281,0.000023935398,0.00006762151,0.00018182359,0.000030841795],"category_scores_gemma":[0.0000054151637,0.00024195443,0.00013963776,0.00009825617,0.00011804293,0.000006552671,0.000022275533,0.00013525267,8.898687e-8],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00009863234,0.00026358225,0.000060117578,0.005534383,0.00031041662,0.000016952046,0.00021489574,0.0000019016245,0.13990012,0.0011841123,0.000025370218,0.8523895],"study_design_scores_gemma":[0.013314223,0.0060719256,0.00083197415,0.024338108,0.001203037,0.0005828531,0.0025707718,0.00008085599,0.268141,0.009651211,0.6685654,0.00464866],"about_ca_topic_score_codex":0.000009119687,"about_ca_topic_score_gemma":0.000007479462,"teacher_disagreement_score":0.8477408,"about_ca_system_score_codex":0.000009079494,"about_ca_system_score_gemma":0.00013519354,"threshold_uncertainty_score":0.98666155},"labels":[],"label_agreement":null},{"id":"W4200414711","doi":"10.1038/s41392-021-00852-5","title":"SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance","year":2021,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; Sun Yat-sen University; National Natural Science Foundation of China","keywords":"Evasion (ethics); Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Strain (injury); Coronavirus disease 2019 (COVID-19); Immune system; 2019-20 coronavirus outbreak; Immune escape; Biology; Immunology; Medicine; Pathology; Infectious disease (medical specialty)","score_opus":0.04435947455376119,"score_gpt":0.3068261158400545,"score_spread":0.26246664128629327,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4200414711","genre_codex":"empirical","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8316427,0.040929075,0.0017078866,0.12159645,0.000764898,0.0026418187,0.00043252273,0.00015662068,0.00012806707],"genre_scores_gemma":[0.24274297,0.0033143123,0.0005907733,0.74750286,0.0040817712,0.0003974103,0.0008036834,0.000226923,0.00033928492],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99727553,0.00020063041,0.0005220953,0.0008677578,0.0005057566,0.00062825304],"domain_scores_gemma":[0.999162,0.000131251,0.00010679891,0.0003143465,0.00024441353,0.000041190233],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00037755768,0.00052466156,0.0007989287,0.0002680592,0.00022716301,0.00011099616,0.00011492499,0.00073193014,0.00007053956],"category_scores_gemma":[0.000017360682,0.00045797604,0.0003689155,0.00017482987,0.0003425582,0.00014565229,0.000012525056,0.0012401849,0.0000030572025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014994276,0.00012725678,0.000051286268,0.0008653171,0.00032880745,0.00008225472,0.0009571569,2.586409e-7,0.96655095,0.000022936098,0.006944996,0.022569329],"study_design_scores_gemma":[0.003570109,0.0007038736,0.00014733996,0.00019397987,0.00006693212,0.00012163481,0.00016565256,0.000046692916,0.5811682,0.00046419428,0.41304275,0.0003086726],"about_ca_topic_score_codex":0.00013485711,"about_ca_topic_score_gemma":0.000010632619,"teacher_disagreement_score":0.6259064,"about_ca_system_score_codex":0.000110175795,"about_ca_system_score_gemma":0.0002657058,"threshold_uncertainty_score":0.9997872},"labels":[],"label_agreement":null},{"id":"W4212787271","doi":"10.1038/s41392-021-00870-3","title":"Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Université de Paris; University of Texas MD Anderson Cancer Center; AbbVie","keywords":"Venetoclax; Myeloid leukemia; Cancer research; Leukemia; MAPK/ERK pathway; Medicine; Myeloid; Apoptosis; Biology; Immunology; Signal transduction; Cell biology; Genetics; Chronic lymphocytic leukemia","score_opus":0.018757685759984183,"score_gpt":0.2636010988375339,"score_spread":0.24484341307754973,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4212787271","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9944087,0.0006160213,0.00053224573,0.0025905247,0.00019723343,0.0012479352,0.00010912484,0.00008136872,0.0002168321],"genre_scores_gemma":[0.9968868,0.00066947314,0.00036221702,0.00071736804,0.00012213769,0.00022870133,0.00027193097,0.000049848702,0.0006915195],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9976924,0.000292651,0.00049643667,0.0004723167,0.0006601911,0.00038598944],"domain_scores_gemma":[0.99915683,0.00011675407,0.00011611237,0.00024025522,0.00015902752,0.00021100008],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005567478,0.00023661811,0.0004534387,0.00054229214,0.00017542898,0.000015010172,0.00013892131,0.0001277143,0.0010957754],"category_scores_gemma":[0.000033411307,0.00022991205,0.000100291916,0.0011313453,0.00012897799,0.00015966399,0.000024400695,0.0004342287,0.0000057087386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.008841748,0.000107238375,0.0004998117,0.000053331594,0.00017123378,0.00002679991,0.0025855207,0.00032372656,0.9822518,0.00013863579,0.00063857075,0.0043615685],"study_design_scores_gemma":[0.010378623,0.0014052544,0.008857058,0.00010003964,0.000027453247,0.00002672698,0.0015491262,0.0005426992,0.9432774,0.00024534058,0.03326109,0.0003291797],"about_ca_topic_score_codex":0.00015583285,"about_ca_topic_score_gemma":0.000026368738,"teacher_disagreement_score":0.038974404,"about_ca_system_score_codex":0.0011745463,"about_ca_system_score_gemma":0.0009593483,"threshold_uncertainty_score":0.9998174},"labels":[],"label_agreement":null},{"id":"W4212932622","doi":"10.1038/s41392-021-00865-0","title":"Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; Shenzhen Bay Laboratory; National Natural Science Foundation of China; Baidu; Sunnybrook Research Institute","keywords":"Mitochondrion; Cell biology; Oxidative phosphorylation; Biology; Intracellular; Cell; Cell culture; Biochemistry; Genetics","score_opus":0.007417147852447031,"score_gpt":0.20595103562095102,"score_spread":0.19853388776850397,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4212932622","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9837313,0.015421168,0.00018861529,0.00007173896,0.00009509858,0.00039175487,0.000039084796,0.00001645517,0.000044766224],"genre_scores_gemma":[0.998792,0.0005830992,0.00009785,0.00013916423,0.000061354986,0.000051834104,0.00021161727,0.00003706179,0.000026031847],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986898,0.00023408562,0.0002316086,0.00047191334,0.00015576917,0.00021686395],"domain_scores_gemma":[0.9996604,0.000011757484,0.00006405574,0.00015865649,0.000028864002,0.00007627443],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014348397,0.00018685347,0.000176775,0.00013757116,0.00015543039,0.000025801684,0.00009750363,0.000093946255,0.00039724665],"category_scores_gemma":[0.000006201009,0.0002149492,0.00006750881,0.00020448011,0.000114636074,0.000014311296,0.000028574019,0.00017212058,9.517854e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00055670785,0.0001798136,0.004327309,0.00001975891,0.000020011295,0.000020023617,0.00091518497,0.0011471355,0.99191076,0.00002192464,0.000012603509,0.0008687928],"study_design_scores_gemma":[0.004770007,0.00060656626,0.124991916,0.0000046033388,0.000017731858,0.00003330417,0.0014807639,0.00064289273,0.86460835,0.00055096735,0.0018819703,0.00041090924],"about_ca_topic_score_codex":0.00008192586,"about_ca_topic_score_gemma":0.000012634942,"teacher_disagreement_score":0.12730236,"about_ca_system_score_codex":0.000043360476,"about_ca_system_score_gemma":0.00004221777,"threshold_uncertainty_score":0.87653744},"labels":[],"label_agreement":null},{"id":"W4214633714","doi":"10.1038/s41392-022-00906-2","title":"Asymmetric, amphiphilic RGD conjugated phthalocyanine for targeted photodynamic therapy of triple negative breast cancer","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Peking University; National Natural Science Foundation of China","keywords":"Photodynamic therapy; Triple-negative breast cancer; Photosensitizer; Cancer research; Phototoxicity; Chemistry; Targeted therapy; Phthalocyanine; Cytotoxicity; Biophysics; Cancer; Medicine; In vitro; Breast cancer; Biochemistry; Photochemistry; Biology; Internal medicine; Organic chemistry","score_opus":0.02304300181852613,"score_gpt":0.2983303512829871,"score_spread":0.275287349464461,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4214633714","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9785975,0.01267732,0.0002736933,0.0025407425,0.00042255936,0.0032567354,0.002016489,0.00014709965,0.00006786323],"genre_scores_gemma":[0.9797119,0.017610352,0.0001379486,0.0004932834,0.00015080073,0.0011456179,0.00027423055,0.00008212212,0.0003937653],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9974387,0.0002822263,0.0005375073,0.0005852152,0.000628862,0.0005274887],"domain_scores_gemma":[0.9987364,0.00018226822,0.00022828417,0.0002489625,0.00041070223,0.00019342887],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00053689384,0.00039066357,0.0007879759,0.00058748736,0.00050884753,0.000018355813,0.00017581326,0.00009857215,0.003417668],"category_scores_gemma":[0.000020895199,0.0003329381,0.00031164015,0.0013845562,0.0003400407,0.00013420323,0.00002192307,0.0004666906,8.76988e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.019359687,0.00084191095,0.0003401453,0.00006146003,0.0015361719,0.000007646081,0.0014295813,0.000093380004,0.9439585,0.00008203815,0.00037171316,0.031917725],"study_design_scores_gemma":[0.04255369,0.0071338457,0.03287305,0.00006215624,0.00011426307,0.00025105145,0.0018635654,0.002935501,0.899636,0.0016930819,0.010136882,0.00074691547],"about_ca_topic_score_codex":0.0007066235,"about_ca_topic_score_gemma":0.000027512593,"teacher_disagreement_score":0.044322543,"about_ca_system_score_codex":0.00020770486,"about_ca_system_score_gemma":0.00025425167,"threshold_uncertainty_score":0.99991226},"labels":[],"label_agreement":null},{"id":"W4221065122","doi":"10.1038/s41392-022-00958-4","title":"Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia","year":2022,"lang":"en","type":"erratum","venue":"Signal Transduction and Targeted Therapy","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Venetoclax; Myeloid leukemia; Cancer research; Medicine; Leukemia; Myeloid; MAPK/ERK pathway; Immunology; Biology; Signal transduction; Chronic lymphocytic leukemia; Genetics","score_opus":0.009645263838694722,"score_gpt":0.22738426148955163,"score_spread":0.2177389976508569,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4221065122","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.82741684,0.029499134,0.00729269,0.0043920344,0.10735267,0.009456941,0.0023695568,0.00046228286,0.011757861],"genre_scores_gemma":[0.9009042,0.013893045,0.00024312122,0.0010935218,0.0022481051,0.0005677256,0.011151783,0.00018325582,0.06971527],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9977177,0.00028068924,0.00059626374,0.00070157455,0.0004014301,0.00030236738],"domain_scores_gemma":[0.9990679,0.00002542287,0.00029688544,0.0003016745,0.00017171049,0.00013637784],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002932825,0.0004010571,0.00045172474,0.00033923073,0.00015882484,0.000030633706,0.00019723416,0.0005794446,0.0006505077],"category_scores_gemma":[0.0000461501,0.00042159905,0.00016239865,0.00053391943,0.00011734565,0.000023464401,0.000028114106,0.00045554785,0.000002856707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018662823,0.000060811173,0.000023661785,0.000046338344,0.00017029597,0.0000026053958,0.00031345774,0.00011703315,0.84711784,0.000018299528,0.14756702,0.002696339],"study_design_scores_gemma":[0.0011631533,0.00046802798,0.00023476736,0.000090740774,0.00001152079,0.0000036150532,0.00014912397,0.000037784775,0.5179639,0.000026597416,0.47954452,0.00030625364],"about_ca_topic_score_codex":0.000084650936,"about_ca_topic_score_gemma":0.00011124574,"teacher_disagreement_score":0.33197752,"about_ca_system_score_codex":0.00025999083,"about_ca_system_score_gemma":0.00080914854,"threshold_uncertainty_score":0.9998236},"labels":[],"label_agreement":null},{"id":"W4223434313","doi":"10.1038/s41392-022-00927-x","title":"LSD1 is required for euchromatic origin firing and replication timing","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Origin recognition complex; Euchromatin; Chromatin; Origin of replication; Pre-replication complex; Control of chromosome duplication; Biology; DNA replication; Replication timing; Licensing factor; Genetics; Eukaryotic DNA replication; SeqA protein domain; DNA replication factor CDT1; Cell biology; DNA; Heterochromatin","score_opus":0.04148904896988815,"score_gpt":0.2963178802413296,"score_spread":0.25482883127144146,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4223434313","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97721714,0.007199097,0.01462524,0.0004631241,0.000094472765,0.00031218547,0.000026361373,0.000014366872,0.000048029087],"genre_scores_gemma":[0.9967977,0.0011591648,0.001321612,0.00017299941,0.0001136922,0.00010141312,0.00014258627,0.000016549451,0.00017428825],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9993392,0.000048410784,0.00013752638,0.00029350954,0.000076115844,0.00010521271],"domain_scores_gemma":[0.99973065,0.0000109181665,0.000053281354,0.0001363549,0.00003134918,0.000037453094],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024062418,0.000085386826,0.000079131925,0.000039010138,0.00027395392,0.000018639044,0.00003991734,0.00004280895,0.00008633642],"category_scores_gemma":[0.000005994616,0.00008911798,0.000038734346,0.00006341613,0.000028061555,0.000005479983,0.000009450307,0.000046706005,2.3235135e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00012345906,0.000023192675,0.00026696327,0.000013118154,0.000029662528,1.0030202e-7,0.0003247432,0.000102999045,0.95908004,0.000062305924,0.00006198945,0.03991141],"study_design_scores_gemma":[0.0011452431,0.0006297889,0.0011734127,0.0000039988668,0.000014033495,0.000006363908,0.00014344114,0.0013756704,0.9195654,0.0024338337,0.07334,0.00016884165],"about_ca_topic_score_codex":0.0000056368362,"about_ca_topic_score_gemma":0.0000010223324,"teacher_disagreement_score":0.07327801,"about_ca_system_score_codex":0.000008252849,"about_ca_system_score_gemma":0.000017151344,"threshold_uncertainty_score":0.3634126},"labels":[],"label_agreement":null},{"id":"W4224437039","doi":"10.1038/s41392-022-00972-6","title":"Signaling cascades in the failing heart and emerging therapeutic strategies","year":2022,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; Terry Fox Foundation; National Natural Science Foundation of China","keywords":"Heart failure; Medicine; Computational biology; Neuroscience; Bioinformatics; Biology; Internal medicine","score_opus":0.053564812657907704,"score_gpt":0.32480371556967846,"score_spread":0.2712389029117708,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4224437039","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.011748723,0.98715484,0.00019211812,0.00007350254,0.00015450733,0.0005844251,0.000029115416,0.00002351205,0.000039247225],"genre_scores_gemma":[0.082658,0.9164005,0.000062068764,0.00020667074,0.00025564377,0.0001725911,0.0001738349,0.000054674394,0.000016025291],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9978693,0.0006733997,0.00038964822,0.00056634797,0.00021654362,0.0002847476],"domain_scores_gemma":[0.99947494,0.00009653833,0.00011390402,0.00023572742,0.000018250554,0.000060609138],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006489484,0.0003924245,0.0005119744,0.00012456508,0.00027940312,0.00012306344,0.00021582522,0.00020802909,0.00023724568],"category_scores_gemma":[0.000008180643,0.0002912422,0.0002423876,0.00026271018,0.00013494171,0.000012766124,0.00002191301,0.0004615443,7.313836e-7],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00018317149,0.00017688554,0.00003770219,0.0019585367,0.00051330344,0.000020520452,0.002021591,0.00022963413,0.055970665,0.0002834274,0.00005578948,0.9385488],"study_design_scores_gemma":[0.00048301375,0.00025702384,0.0000082719,0.00030521778,0.00013600416,0.00013151723,0.0021001229,0.000012191376,0.0020026674,0.00038310813,0.9937369,0.00044394968],"about_ca_topic_score_codex":0.000018754065,"about_ca_topic_score_gemma":0.0000042143224,"teacher_disagreement_score":0.99368113,"about_ca_system_score_codex":0.000015371541,"about_ca_system_score_gemma":0.00016329707,"threshold_uncertainty_score":0.999954},"labels":[],"label_agreement":null},{"id":"W4229333976","doi":"10.1038/s41392-022-01005-y","title":"Prokaryotic gasdermins: ancestors of eukaryotic counterparts direct the pyroptosis and cell fates","year":2022,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Biotechnology Research Institute","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Foundation for the National Institutes of Health","keywords":"Pyroptosis; Biology; Evolutionary biology; Computational biology; Cell biology; Genetics; Programmed cell death; Apoptosis","score_opus":0.00967234889818965,"score_gpt":0.20705894176933057,"score_spread":0.1973865928711409,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4229333976","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.873503,0.081299394,0.00008211963,0.04152018,0.00094905455,0.0012781519,0.0001834251,0.00004200586,0.0011426696],"genre_scores_gemma":[0.934837,0.028556932,0.000025500654,0.033712305,0.0006689211,0.00012846838,0.00079302513,0.00007820864,0.0011996394],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9986777,0.00019398218,0.0002745211,0.00040950548,0.00019411217,0.00025022944],"domain_scores_gemma":[0.9995046,0.000024868723,0.00015432341,0.00023433499,0.000055767392,0.00002605195],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015544448,0.00029900784,0.00028560738,0.00008055588,0.00022081776,0.000029523466,0.00016097537,0.0002560253,0.00036538293],"category_scores_gemma":[0.0000036834983,0.00022601566,0.00014448215,0.000111449015,0.0002790659,0.0000092335,0.000021814685,0.00043738043,8.314191e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013260597,0.00028139912,0.0029389737,0.0007056729,0.0012019275,0.000026939299,0.0027821425,0.00016511799,0.7933497,0.000009154844,0.18737897,0.009833928],"study_design_scores_gemma":[0.001063753,0.0011946148,0.00064986316,0.000026608364,0.000089981426,0.000024668383,0.00040746154,0.000021114201,0.25569838,0.00007279999,0.74032176,0.00042899506],"about_ca_topic_score_codex":0.000033178312,"about_ca_topic_score_gemma":0.0000030839115,"teacher_disagreement_score":0.55294275,"about_ca_system_score_codex":0.000007959625,"about_ca_system_score_gemma":0.000059113587,"threshold_uncertainty_score":0.92166513},"labels":[],"label_agreement":null},{"id":"W4285009772","doi":"10.1038/s41392-022-01082-z","title":"Nanoparticles in the diagnosis and treatment of vascular aging and related diseases","year":2022,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Advanced Nanomaterials in Catalysis","field":"Materials Science","cited_by":103,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Aging","funders":"National Natural Science Foundation of China","keywords":"Medicine; Oxidative stress; Inflammation; Senescence; Epigenetics; Bioinformatics; Pathology; Biology; Immunology; Internal medicine","score_opus":0.048245425835887694,"score_gpt":0.3046032158332589,"score_spread":0.2563577899973712,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4285009772","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.17167057,0.82754844,0.000003540115,0.000026874372,0.000111743815,0.0005152504,0.0001005051,0.000020801772,0.000002253679],"genre_scores_gemma":[0.029174266,0.97025096,0.00006027587,0.000008305647,0.00003255438,0.0003951297,0.000053415486,0.00002111818,0.0000039631723],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99836564,0.0005334599,0.00041189094,0.00037083935,0.00016353157,0.00015463372],"domain_scores_gemma":[0.9993494,0.00026229475,0.00016198578,0.00017474484,0.000009103349,0.00004243669],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027145998,0.00024491665,0.0007423165,0.00013624749,0.00015358586,0.00004341739,0.000089189,0.00006605371,0.000821603],"category_scores_gemma":[0.000007312046,0.00015332618,0.0001286586,0.00027990693,0.0001876058,0.00011508589,0.000011369104,0.000057803947,7.0148593e-7],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000038246915,0.00022926582,0.00007524336,0.0007230647,0.00013434264,0.000012596917,0.0017066514,0.000013988821,0.0116578005,0.000057852016,0.0000012520434,0.9853497],"study_design_scores_gemma":[0.0028878816,0.0011370364,0.00046668938,0.0012027909,0.0017225012,0.00013365626,0.00095256465,0.000012920067,0.03856784,0.0018082397,0.95025605,0.00085182465],"about_ca_topic_score_codex":0.000034436707,"about_ca_topic_score_gemma":0.0000025087381,"teacher_disagreement_score":0.98449785,"about_ca_system_score_codex":0.000033157565,"about_ca_system_score_gemma":0.000026605614,"threshold_uncertainty_score":0.89959764},"labels":[],"label_agreement":null},{"id":"W4285389623","doi":"10.1038/s41392-022-01075-y","title":"Correction to: Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src","year":2022,"lang":"en","type":"erratum","venue":"Signal Transduction and Targeted Therapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Mesenchymal stem cell; Extracellular vesicles; Oxidative stress; Cell biology; Senescence; Stem cell; Endothelial stem cell; Extracellular; Proto-oncogene tyrosine-protein kinase Src; Intracellular; Vesicle; Chemistry; Biology; Bioinformatics; Biochemistry; Signal transduction; In vitro; Membrane","score_opus":0.012643946325885384,"score_gpt":0.22432461827577477,"score_spread":0.21168067194988938,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4285389623","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9751085,0.007985726,0.005326271,0.00007824558,0.009378728,0.001314946,0.00048894563,0.000047874266,0.00027078463],"genre_scores_gemma":[0.98588574,0.002273423,0.00037819892,0.000053829594,0.00067676697,0.000115227675,0.0015818271,0.00011700529,0.008917959],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99678826,0.0006406697,0.0007073153,0.0010140261,0.00042315453,0.0004265998],"domain_scores_gemma":[0.99871606,0.000039974744,0.00042820885,0.00044150077,0.0001697211,0.00020452948],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00034708233,0.00055723824,0.0005094338,0.00028929298,0.0001770884,0.00003893646,0.00030341186,0.0004925973,0.00043562474],"category_scores_gemma":[0.000009856435,0.00062042795,0.00025907304,0.0003651281,0.0001461958,0.00002166077,0.00004926868,0.0006718319,0.0000036822262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0012689548,0.00040194052,0.000057966143,0.00012764592,0.000121360674,0.000014758239,0.0008790764,0.00082266243,0.9870398,0.000004037969,0.002394987,0.0068667913],"study_design_scores_gemma":[0.0014236855,0.000863671,0.0007046191,0.000113374714,0.000053093387,0.0000110193605,0.0006459647,0.00058810145,0.9865279,0.0000527174,0.00841874,0.00059706974],"about_ca_topic_score_codex":0.00014355182,"about_ca_topic_score_gemma":0.00007822221,"teacher_disagreement_score":0.010777283,"about_ca_system_score_codex":0.00007495979,"about_ca_system_score_gemma":0.00025393456,"threshold_uncertainty_score":0.9996247},"labels":[],"label_agreement":null},{"id":"W4289856259","doi":"10.1038/s41392-022-01059-y","title":"Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China","keywords":"Psoriasis; Medicine; Umbilical cord; Mesenchymal stem cell; Peripheral blood mononuclear cell; Adverse effect; Immune system; Immunology; Transplantation; Interleukin 17; Internal medicine; Psoriasis Area and Severity Index; Biomarker; Gastroenterology; Pathology; In vitro","score_opus":0.048788719943454704,"score_gpt":0.2857586974476647,"score_spread":0.23696997750420998,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4289856259","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99282676,0.003436649,0.00025595204,0.00013756237,0.0014195609,0.0014497214,0.00027280388,0.00014221092,0.00005877341],"genre_scores_gemma":[0.9975167,0.00007063749,0.000041083335,0.00009709893,0.00013104995,0.00062082947,0.00018247639,0.000035537178,0.0013045985],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99812686,0.000531434,0.0003567775,0.0005354399,0.00008481933,0.0003646917],"domain_scores_gemma":[0.9995201,0.00008055465,0.00010365782,0.00019303983,0.000053637552,0.000048996084],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003559982,0.0002819907,0.0003797147,0.00015551149,0.0010337565,0.00002589084,0.00015135195,0.0001218759,0.0034383945],"category_scores_gemma":[0.0000011507258,0.0002584921,0.00020587769,0.00020957831,0.00010294152,0.00008321343,0.000016450287,0.00022522939,0.000012543973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.005158063,0.007988072,0.00017342888,0.000008523435,0.0008462526,0.000008014965,0.0025531533,0.000012142196,0.8520115,0.00014737553,0.00041801046,0.13067546],"study_design_scores_gemma":[0.050466966,0.044519164,0.0007407421,0.000007729232,0.00047173616,0.00010683755,0.010648237,0.000015214104,0.8134506,0.00057214353,0.07823739,0.00076325884],"about_ca_topic_score_codex":0.00003558248,"about_ca_topic_score_gemma":0.000010463743,"teacher_disagreement_score":0.1299122,"about_ca_system_score_codex":0.000050252358,"about_ca_system_score_gemma":0.000034098983,"threshold_uncertainty_score":0.9999867},"labels":[],"label_agreement":null},{"id":"W4291019935","doi":"10.1038/s41392-022-01067-y","title":"Multi-omics characterization and therapeutic liability of ferroptosis in melanoma","year":2022,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"National Key Research and Development Program of China; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Omics; Melanoma; Computational biology; Medicine; Biology; Bioinformatics; Cancer research","score_opus":0.032772314029297825,"score_gpt":0.2626254889972294,"score_spread":0.22985317496793156,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4291019935","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8873698,0.0043782117,0.00036684348,0.106076986,0.00032592894,0.0011993824,0.00020398732,0.000054244516,0.000024602983],"genre_scores_gemma":[0.9147867,0.013848189,0.00029128103,0.068926394,0.00046163643,0.0002413764,0.0010938337,0.000087885346,0.00026272523],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.99833715,0.00021739703,0.000453638,0.000490638,0.00027508553,0.00022610473],"domain_scores_gemma":[0.99947864,0.00003792965,0.00016458525,0.00019343662,0.0000722421,0.00005314721],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00022804711,0.00029623386,0.0006136947,0.00027296043,0.00007853003,0.000018130691,0.00006541466,0.00037969937,0.0016615031],"category_scores_gemma":[0.0000032731887,0.0002644116,0.00013587806,0.00028491128,0.00014842903,0.00006336534,0.000010001171,0.00089836115,4.963463e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0037876703,0.0012043467,0.05339238,0.001583578,0.0009501977,0.00003745554,0.0048116404,0.000011418854,0.772017,0.000025153524,0.0010747795,0.1611044],"study_design_scores_gemma":[0.012147959,0.00426756,0.27249613,0.00028747387,0.00045827508,0.00010335372,0.0005530014,0.0013430469,0.089227475,0.00014306292,0.61779547,0.0011771874],"about_ca_topic_score_codex":0.00008170172,"about_ca_topic_score_gemma":0.000003377723,"teacher_disagreement_score":0.6827895,"about_ca_system_score_codex":0.00007194219,"about_ca_system_score_gemma":0.00007617778,"threshold_uncertainty_score":0.9999808},"labels":[],"label_agreement":null},{"id":"W4293537593","doi":"10.1038/s41392-022-01152-2","title":"The RING finger protein family in health and disease","year":2022,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Calgary","funders":"Qinghai Provincial Department of Science and Technology; Natural Science Foundation of Fujian Province; National Natural Science Foundation of China","keywords":"Ring finger; Disease; Computational biology; Ring (chemistry); Biology; Genetics; Medicine; Pathology; Chemistry; Gene","score_opus":0.04467298119070677,"score_gpt":0.2947246820252592,"score_spread":0.2500517008345524,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4293537593","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0012319653,0.99724317,0.000051517272,0.00018617451,0.000096274256,0.001075045,0.00004594871,0.000012791159,0.000057138615],"genre_scores_gemma":[0.0008703217,0.9978886,0.000037144102,0.00018645574,0.00015077472,0.00043016064,0.00018183669,0.00003560919,0.0002190842],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99851173,0.000435452,0.00030914255,0.00039194984,0.000114361756,0.00023735008],"domain_scores_gemma":[0.9995045,0.000021595539,0.00011591566,0.00016502064,0.000009811961,0.00018315647],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000431998,0.0002418808,0.0003423343,0.00006217624,0.00031701056,0.000042761287,0.000106454274,0.00010021698,0.00007059591],"category_scores_gemma":[0.0000150661435,0.00017380354,0.00012795704,0.00012133825,0.000081860686,0.000003628046,0.00002320382,0.00029631672,7.4410735e-7],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013163126,0.000034374843,0.0000029974258,0.0011643056,0.000057188685,0.0000024546355,0.00009123319,0.0000010206769,0.0012733035,0.00013895879,0.000044570177,0.997058],"study_design_scores_gemma":[0.00034406857,0.00025095925,0.0000061723954,0.00039007317,0.0000091463135,0.00000805677,0.00006110726,0.0000035121402,0.00016906415,0.00020622199,0.9983542,0.00019745064],"about_ca_topic_score_codex":0.000018448649,"about_ca_topic_score_gemma":0.00000411842,"teacher_disagreement_score":0.9983096,"about_ca_system_score_codex":0.000017502281,"about_ca_system_score_gemma":0.00030726325,"threshold_uncertainty_score":0.70875025},"labels":[],"label_agreement":null},{"id":"W4296796569","doi":"10.1038/s41392-022-01157-x","title":"Clusterin transduces Alzheimer-risk signals to amyloidogenesis","year":2022,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Zhengzhou University; National Natural Science Foundation of China; First Affiliated Hospital of Zhengzhou University; Guangdong Provincial People's Hospital; University of British Columbia; Capital Medical University","keywords":"Clusterin; Alzheimer's disease; Biology; Neuroscience; Cell biology; Medicine; Disease; Genetics; Pathology; Apoptosis","score_opus":0.04420614918602479,"score_gpt":0.28798172666711924,"score_spread":0.24377557748109446,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4296796569","genre_codex":"commentary","genre_gemma":"commentary","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"commentary","genre_consensus":"commentary","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.2357321,0.02535299,0.0024701445,0.7239204,0.003220174,0.005212493,0.0022470297,0.00083265256,0.0010120143],"genre_scores_gemma":[0.14712551,0.009864674,0.0015774401,0.826809,0.00757855,0.0014410153,0.002383336,0.00055502803,0.0026654387],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99589676,0.0006973758,0.00071261014,0.0012354322,0.0007504607,0.00070735463],"domain_scores_gemma":[0.9985778,0.00016200174,0.00020702615,0.0005706238,0.00012750684,0.00035504557],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003910749,0.0007623784,0.0010768696,0.0006983112,0.00036727748,0.000058865266,0.00026789046,0.00071323727,0.0293881],"category_scores_gemma":[0.00001294216,0.00072987564,0.0005419536,0.00054324797,0.00020494265,0.00009057004,0.000036656846,0.0018782446,0.00007938192],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.011605254,0.00074245065,0.0005231199,0.00063880946,0.005183594,0.002483435,0.005255818,0.0004933598,0.20437306,0.0000064780033,0.65140307,0.11729157],"study_design_scores_gemma":[0.002986552,0.0024348926,0.0008999332,0.00006614073,0.0010167857,0.00067206804,0.00015737285,0.00004223834,0.016333329,0.00020014615,0.97431785,0.00087269983],"about_ca_topic_score_codex":0.00008200428,"about_ca_topic_score_gemma":0.0000058938717,"teacher_disagreement_score":0.32291478,"about_ca_system_score_codex":0.00008977334,"about_ca_system_score_gemma":0.00016514667,"threshold_uncertainty_score":0.99951524},"labels":[],"label_agreement":null},{"id":"W4299878889","doi":"10.1038/s41392-022-01148-y","title":"Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"Canadian Institutes of Health Research; Natural Science Foundation of Chongqing; Ministry of Science and Technology, Taiwan; Chongqing Medical University; National Science Council; Chongqing Municipal Education Commission; Heart and Stroke Foundation of British Columbia and Yukon; National Natural Science Foundation of China; Government of Canada; China Medical University; Heart and Stroke Foundation of Canada","keywords":"Glutamate receptor; Long-term potentiation; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; GABAA receptor; Neuroscience; NMDA receptor; Chemistry; Biology; Pharmacology; Receptor; Biochemistry","score_opus":0.038293121650822645,"score_gpt":0.30075809924055014,"score_spread":0.2624649775897275,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4299878889","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9944746,0.00014508718,0.000027983506,0.004678096,0.0002027163,0.0003941223,0.00003872261,0.000019121891,0.000019572713],"genre_scores_gemma":[0.9979101,0.00052981486,0.000009882415,0.0013718606,0.000027694672,0.000059329006,0.0000048882175,0.000011326047,0.00007509415],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9978525,0.0009896526,0.00021471272,0.0003320275,0.0004049158,0.00020615837],"domain_scores_gemma":[0.9993572,0.0004258586,0.000074718315,0.0000788807,0.000018811596,0.000044505487],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00055944745,0.00010553486,0.00011513222,0.00020548968,0.0003938281,0.000041424668,0.00014905544,0.000022563783,0.0005945075],"category_scores_gemma":[0.000044671662,0.0000842309,0.000029966444,0.0006430866,0.00037215246,0.0002294834,0.00001621143,0.00026662782,0.0000013488409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0004329759,0.000097827135,0.00043199994,0.000011612601,0.0000014961925,0.000006569166,0.002483674,0.000093134586,0.99310017,0.0003538286,0.00006528282,0.0029214185],"study_design_scores_gemma":[0.002057376,0.0012050696,0.06431385,0.000003933091,0.0000040802693,0.00008041373,0.000872644,0.0013398727,0.9245563,0.0029489172,0.0024639352,0.00015357917],"about_ca_topic_score_codex":0.000011323231,"about_ca_topic_score_gemma":0.0000017411638,"teacher_disagreement_score":0.06854385,"about_ca_system_score_codex":0.000010014101,"about_ca_system_score_gemma":0.00003255186,"threshold_uncertainty_score":0.650944},"labels":[],"label_agreement":null},{"id":"W4301595304","doi":"10.1038/s41392-022-01186-6","title":"Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration","year":2022,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":false,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Canadian Institutes of Health Research; European Commission","keywords":"Regeneration (biology); Peripheral nerve; Microbiome; Metabolite; Medicine; Biology; Cell biology; Bioinformatics; Anatomy; Internal medicine","score_opus":0.037516674017994626,"score_gpt":0.2711523519723788,"score_spread":0.23363567795438417,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4301595304","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8459765,0.0032980214,0.00041505715,0.14276783,0.004865392,0.0015820116,0.00051194074,0.0003617509,0.00022149766],"genre_scores_gemma":[0.78545773,0.0047225887,0.00018191237,0.1909816,0.009453064,0.00079128024,0.0023510994,0.00023659712,0.005824142],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99418205,0.002235427,0.0006556394,0.0016771624,0.00043157322,0.00081816805],"domain_scores_gemma":[0.9987241,0.00020321703,0.00034808516,0.00046269628,0.00014809893,0.00011377847],"candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003762016,0.00071404735,0.0007113781,0.00038297148,0.001381222,0.00019784115,0.00048739064,0.0008091564,0.0035035706],"category_scores_gemma":[0.000032669737,0.0006432788,0.00033980518,0.0006154485,0.0005227776,0.00048400514,0.000053989723,0.0028789465,0.00002120946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0005335506,0.00008792893,0.0000022557308,0.000045977657,0.000096508535,0.0000874919,0.0004663283,0.00005742922,0.9833449,0.0000710507,0.012615623,0.002590967],"study_design_scores_gemma":[0.001078042,0.0011890569,0.00001742662,0.000009744901,0.000031409883,0.0001620334,0.000034186836,0.00012693169,0.87817645,0.00043237032,0.1181668,0.0005755477],"about_ca_topic_score_codex":0.00006229777,"about_ca_topic_score_gemma":0.000004290215,"teacher_disagreement_score":0.105551176,"about_ca_system_score_codex":0.000076196746,"about_ca_system_score_gemma":0.00019985164,"threshold_uncertainty_score":0.9999188},"labels":[],"label_agreement":null},{"id":"W4313251504","doi":"10.1038/s41392-022-01239-w","title":"SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fundamental Research Funds for the Central Universities; National Medical Research Council; National Natural Science Foundation of China","keywords":"Biology; RNA; Kinase; Cyclin-dependent kinase 2; Virology; Coronaviridae; Viral replication; RNA-dependent RNA polymerase; Cell biology; Subgenomic mRNA; Coronavirus disease 2019 (COVID-19); Genetics; Virus; Protein kinase A; Gene; Disease","score_opus":0.03699022197621208,"score_gpt":0.3044330731505513,"score_spread":0.2674428511743392,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4313251504","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99266785,0.0019661104,0.0011103774,0.002166844,0.00027191898,0.0009481671,0.000039370185,0.00016761485,0.0006617477],"genre_scores_gemma":[0.9807324,0.00004792276,0.0002901861,0.018193828,0.00028164012,0.0003012009,0.000011979403,0.00006011494,0.00008075844],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99778956,0.00021245262,0.00030564473,0.00055803027,0.000666306,0.00046801846],"domain_scores_gemma":[0.9994288,0.00004476259,0.000048405283,0.0002974431,0.0000938533,0.00008672612],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004895875,0.00027037974,0.00036902638,0.00036726243,0.00040681625,0.00004750899,0.00016548698,0.00009335119,0.0006354766],"category_scores_gemma":[0.000018551915,0.00024721926,0.00019842379,0.0005967396,0.0000981876,0.00010963685,0.000027776736,0.0005012248,0.000043485026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002310249,0.00039015646,0.00022843377,0.00003995966,0.00014691339,0.00011308456,0.0010995124,0.0000036873555,0.9402556,0.000082601306,0.0002980724,0.05503176],"study_design_scores_gemma":[0.0014879297,0.0010087746,0.00013285171,0.000016151305,0.000031936994,0.00004379787,0.00021789936,0.00019123443,0.74523544,0.0003101489,0.2511139,0.00020994282],"about_ca_topic_score_codex":0.00015712308,"about_ca_topic_score_gemma":0.0000046384475,"teacher_disagreement_score":0.2508158,"about_ca_system_score_codex":0.00011875984,"about_ca_system_score_gemma":0.00014983438,"threshold_uncertainty_score":0.99999803},"labels":[],"label_agreement":null},{"id":"W4318816500","doi":"10.1038/s41392-023-01321-x","title":"Gonadotropin releasing hormone (GnRH): a hormone therapy boosts cognition in Down syndrome and dementia","year":2023,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Dementia; Hormone; Down syndrome; Gonadotropin-releasing hormone; Medicine; Gonadotropin; Endocrinology; Cognition; Hormone therapy; Internal medicine; Bioinformatics; Growth hormone; Biology; Luteinizing hormone; Psychiatry; Disease; Cancer","score_opus":0.03659926269509402,"score_gpt":0.2549163106883393,"score_spread":0.2183170479932453,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4318816500","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9040033,0.03308272,0.0002945432,0.06001353,0.0005322888,0.0014139719,0.00024253747,0.0003410829,0.00007602987],"genre_scores_gemma":[0.6843782,0.26391435,0.00004326068,0.050329253,0.000533399,0.00019472929,0.00014684444,0.00014061159,0.00031935697],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9969205,0.0004796475,0.0005100872,0.0009826663,0.00050986785,0.00059721933],"domain_scores_gemma":[0.9992429,0.00020956986,0.00018491506,0.00021949461,0.000040517232,0.000102571845],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006800925,0.00052293384,0.00051584846,0.0005568855,0.00028439803,0.00018843747,0.0001675424,0.0005368394,0.00023943963],"category_scores_gemma":[0.000016964199,0.00048533396,0.00014339967,0.0005557338,0.00024956558,0.00026199888,0.00001678178,0.0011861592,0.00002079167],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024780422,0.00013588536,0.00005216414,0.000055061184,0.0001643178,0.0012038209,0.000526058,0.0000071945833,0.8987791,0.00002288288,0.010684865,0.08589061],"study_design_scores_gemma":[0.035061356,0.010435282,0.1851363,0.0009961518,0.0003468665,0.0039060558,0.00049878884,0.001059138,0.16579065,0.009688479,0.5812581,0.0058227945],"about_ca_topic_score_codex":0.00013652357,"about_ca_topic_score_gemma":0.0000066501207,"teacher_disagreement_score":0.7329885,"about_ca_system_score_codex":0.000036667854,"about_ca_system_score_gemma":0.00005602624,"threshold_uncertainty_score":0.99975985},"labels":[],"label_agreement":null},{"id":"W4321166935","doi":"10.1038/s41392-022-01268-5","title":"B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin","year":2023,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Wuhan Science and Technology Project; Hubei University; Hubei University of Technology; National Natural Science Foundation of China","keywords":"Wnt signaling pathway; Phosphorylation; Pancreatic cancer; Catenin; Cancer research; Receptor tyrosine kinase; Tyrosine; Tyrosine kinase; Signal transduction; Tyrosine phosphorylation; Biology; Cell biology; Chemistry; Cancer; Biochemistry; Genetics","score_opus":0.012786494962556696,"score_gpt":0.2378651535204363,"score_spread":0.22507865855787962,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4321166935","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99318564,0.0029634002,0.0027441967,0.0003252559,0.00026908354,0.0003159731,0.000022825325,0.00012001212,0.000053594067],"genre_scores_gemma":[0.9935883,0.0043231137,0.00031703594,0.000071211376,0.000275453,0.00005625398,0.0010439552,0.000050093153,0.00027455745],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99884677,0.00007584401,0.0002403611,0.0004120892,0.00016957577,0.00025536586],"domain_scores_gemma":[0.9995496,0.00003111167,0.00011009294,0.0001422969,0.000105132865,0.000061717845],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013894493,0.0002239226,0.00017744898,0.0000912006,0.00017663097,0.00003723901,0.000062283136,0.00013743826,0.00013739943],"category_scores_gemma":[0.000012926526,0.00019512913,0.00006625736,0.0004961321,0.00007901643,0.000026889395,0.000007647809,0.00009131283,0.000014593957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0008838365,0.00003888077,0.0023347395,0.000015448728,0.00015429921,0.0000020357538,0.00035179895,0.0018824991,0.9876679,0.000014766585,0.00017275028,0.006481038],"study_design_scores_gemma":[0.0018048061,0.0005195956,0.009290982,0.00004404944,0.000035488003,0.000034266694,0.00031270803,0.0017365741,0.9796337,0.00010710905,0.006184996,0.00029573505],"about_ca_topic_score_codex":0.000089219866,"about_ca_topic_score_gemma":0.000022545139,"teacher_disagreement_score":0.008034217,"about_ca_system_score_codex":0.00002969532,"about_ca_system_score_gemma":0.00005801996,"threshold_uncertainty_score":0.79571354},"labels":[],"label_agreement":null},{"id":"W4321786118","doi":"10.1038/s41392-023-01346-2","title":"From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism","year":2023,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; Public Health Ontario; University of Toronto; University Health Network","funders":"West China Hospital, Sichuan University; Peking University; Sichuan University; Tsinghua University; National Natural Science Foundation of China","keywords":"RNA splicing; Mycobacterium tuberculosis; Tuberculosis; Biology; Biomarker; Intron; Transcriptome; Exon; Computational biology; Alternative splicing; Proteome; Genetics; Bioinformatics; Medicine; RNA; Gene; Gene expression; Pathology","score_opus":0.015425916255487927,"score_gpt":0.24543156056400614,"score_spread":0.23000564430851822,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4321786118","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.993571,0.001894743,0.002878118,0.00092401315,0.00026056267,0.0003382714,0.0000352422,0.000058422193,0.000039655177],"genre_scores_gemma":[0.99637324,0.0020626744,0.00038570038,0.0004801906,0.00028720344,0.000037091733,0.00009417361,0.000035812667,0.00024389893],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99883294,0.000101515616,0.000178316,0.000483043,0.00016315635,0.00024105531],"domain_scores_gemma":[0.99959266,0.000011338068,0.00003652122,0.00015545514,0.000044173234,0.00015987737],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018912248,0.00019985481,0.0001647321,0.00011408632,0.00017618836,0.000040062547,0.00007889053,0.00018859514,0.00035504566],"category_scores_gemma":[0.000008311282,0.00018854502,0.00008114566,0.00017001401,0.000026766265,0.000011199035,0.000022746337,0.00006359563,0.000024599516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028936024,0.000018863073,0.0000134365155,0.000005799556,0.0001351139,0.0000049423093,0.00026537353,0.000016461323,0.9812758,0.0002531023,0.00009111979,0.017630627],"study_design_scores_gemma":[0.000607107,0.00029801813,0.0012065109,0.00001623949,0.000022514347,0.000018038572,0.00024073143,0.00013956442,0.9899355,0.0049809865,0.0022887941,0.0002460024],"about_ca_topic_score_codex":0.00008736181,"about_ca_topic_score_gemma":0.000007468328,"teacher_disagreement_score":0.017384624,"about_ca_system_score_codex":0.000005601141,"about_ca_system_score_gemma":0.000021960805,"threshold_uncertainty_score":0.7688643},"labels":[],"label_agreement":null},{"id":"W4324143902","doi":"10.1038/s41392-023-01387-7","title":"Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium","year":2023,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Science Fund for Distinguished Young Scholars; National Science Foundation","keywords":"Mucus; Cilium; Respiratory epithelium; Epithelium; Mucociliary clearance; Airway; Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Coronavirus disease 2019 (COVID-19); Cell biology; Pathology; Medicine; Virology; Lung; Internal medicine","score_opus":0.039103403151448876,"score_gpt":0.3119509807382939,"score_spread":0.272847577586845,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4324143902","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.96371,0.008775885,0.00010314305,0.026120538,0.00019121534,0.00081793364,0.00011085472,0.00008134532,0.00008906728],"genre_scores_gemma":[0.9725408,0.009289831,0.0012742515,0.015086377,0.0011231657,0.000073769836,0.00020615791,0.00014725253,0.00025842062],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9980551,0.00016532856,0.00047420184,0.0005575723,0.0003484856,0.00039931055],"domain_scores_gemma":[0.99917305,0.00033446157,0.00014669252,0.00016256345,0.00011140281,0.000071819806],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003739737,0.0003369837,0.00063174416,0.00047950514,0.00011198339,0.00005487832,0.00006700796,0.000348322,0.00011083915],"category_scores_gemma":[0.000061702056,0.00029114136,0.00008541723,0.0003340993,0.00030050904,0.00015340249,0.000019899808,0.0010546418,0.0000019868805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029213683,0.000033757085,0.004960005,0.0008970106,0.00014397776,0.00005249632,0.0009856201,0.0000036033007,0.9732457,0.0000022786028,0.0025677984,0.01681565],"study_design_scores_gemma":[0.00959794,0.0028492615,0.048251465,0.0021286728,0.00015233453,0.00049363414,0.001275095,0.0008078524,0.79419154,0.0010908014,0.1379468,0.0012146333],"about_ca_topic_score_codex":0.00039094873,"about_ca_topic_score_gemma":0.00009832157,"teacher_disagreement_score":0.17905416,"about_ca_system_score_codex":0.000029948951,"about_ca_system_score_gemma":0.000075810436,"threshold_uncertainty_score":0.99995404},"labels":[],"label_agreement":null},{"id":"W4376642196","doi":"10.1038/s41392-023-01403-w","title":"SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer","year":2023,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":true,"ca_institutions":"","funders":"Renji Hospital; Guangdong Provincial People's Hospital; National Natural Science Foundation of China","keywords":"Syk; Cancer research; Downregulation and upregulation; Population; In vivo; Targeted therapy; Medicine; Biology; Lung cancer; Cell; Oncology; Cancer; Internal medicine; Gene; Tyrosine kinase; Genetics; Receptor","score_opus":0.012581210938398363,"score_gpt":0.297163919530721,"score_spread":0.28458270859232265,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4376642196","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99594384,0.00077297876,0.00009167921,0.0016476538,0.00019843582,0.00078052713,0.00033413302,0.00015606171,0.00007470523],"genre_scores_gemma":[0.99688137,0.00073288474,0.00015345888,0.0006641552,0.000080198035,0.0001490371,0.00012540063,0.00004691209,0.0011666098],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986282,0.00014298799,0.00025477653,0.00035803355,0.00028671345,0.00032928787],"domain_scores_gemma":[0.9994126,0.00012712281,0.000069588,0.00010868992,0.00009953703,0.0001824506],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025971237,0.00021106753,0.00028786086,0.00039052346,0.00013358555,0.000035419336,0.00003632908,0.00008536557,0.00045890512],"category_scores_gemma":[0.000016914379,0.0001631487,0.00005805701,0.001085375,0.00005043162,0.00013164198,0.0000045355605,0.00018199327,0.000010406184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0094217,0.00034222877,0.020104192,0.00004318885,0.0005243919,0.000101627054,0.0141415605,0.0009720112,0.94136864,0.0000020682917,0.00088143104,0.012096962],"study_design_scores_gemma":[0.04486332,0.0048328713,0.28882417,0.0014268793,0.00044946154,0.000020850466,0.0028304025,0.0019469179,0.6407017,0.00021425098,0.0127563495,0.0011327942],"about_ca_topic_score_codex":0.00034983907,"about_ca_topic_score_gemma":0.000053285454,"teacher_disagreement_score":0.3006669,"about_ca_system_score_codex":0.00018365598,"about_ca_system_score_gemma":0.0002303769,"threshold_uncertainty_score":0.6653011},"labels":[],"label_agreement":null},{"id":"W4379364758","doi":"10.1038/s41392-023-01431-6","title":"CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors","year":2023,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China-Yunnan Joint Fund; National Natural Science Foundation of China","keywords":"Transmembrane domain; Amyloid precursor protein; Transmembrane protein; Neuroscience; Biology; Prefrontal cortex; Cell biology; Gene; Genetics; Receptor; Medicine; Internal medicine; Alzheimer's disease","score_opus":0.02091473214823582,"score_gpt":0.2650233299637968,"score_spread":0.24410859781556096,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4379364758","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.99136513,0.0015238802,0.00074981916,0.004147048,0.00034842495,0.0007706226,0.00015311674,0.00075128686,0.00019069492],"genre_scores_gemma":[0.99500066,0.0034261947,0.000055858687,0.000213167,0.000039415296,0.00008064122,0.00017735596,0.00008514028,0.0009215443],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99693733,0.00048131158,0.00043072528,0.0008552198,0.00054694124,0.00074844353],"domain_scores_gemma":[0.999263,0.00007559454,0.00009412774,0.0002810252,0.000012965597,0.00027328686],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00041733697,0.00035025686,0.00029387206,0.00035508536,0.00055796286,0.00014427547,0.00027227215,0.00023382176,0.0018479486],"category_scores_gemma":[0.000014016352,0.00032825794,0.00012489314,0.0016245554,0.00040073282,0.0003373226,0.000025019843,0.00059573265,0.0001966549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00019127292,0.00017089678,0.00006315536,0.00001008166,0.000028570945,0.00006900629,0.0010207174,0.000025384063,0.9857491,0.003076907,0.000602293,0.008992586],"study_design_scores_gemma":[0.0022641688,0.00045443946,0.0010937082,0.000008289076,0.000012331687,0.000036279613,0.00018121579,0.0016287966,0.97750515,0.010435954,0.0059594475,0.00042020314],"about_ca_topic_score_codex":0.00008615171,"about_ca_topic_score_gemma":0.0000051962625,"teacher_disagreement_score":0.008572383,"about_ca_system_score_codex":0.00004036774,"about_ca_system_score_gemma":0.00006108563,"threshold_uncertainty_score":0.999917},"labels":[],"label_agreement":null},{"id":"W4382601497","doi":"10.1038/s41392-023-01484-7","title":"Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future","year":2023,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":887,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Senile plaques; Amyloid β; Disease; Clinical trial; Biochemistry of Alzheimer's disease; Alzheimer's disease; Medicine; Amyloid (mycology); Drug development; Neuroscience; Bioinformatics; Psychology; Amyloid precursor protein; Pathology; Psychiatry; Drug; Biology","score_opus":0.12237377169683425,"score_gpt":0.3752099604563784,"score_spread":0.25283618875954417,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4382601497","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000058072797,0.99292755,0.000021808977,0.0018193114,0.00023983541,0.0040170383,0.0006535024,0.00023231031,0.000030598854],"genre_scores_gemma":[0.0005342725,0.9946244,0.000087610344,0.0001160119,0.0013073534,0.0012931584,0.001812865,0.00018215772,0.000042174684],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99755067,0.00020853353,0.0004406171,0.00085731025,0.0004269681,0.0005158767],"domain_scores_gemma":[0.9984321,0.00019845765,0.00014735706,0.0003293277,0.00014994029,0.0007428098],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00022140717,0.00069315854,0.001376092,0.00037540164,0.00028287555,0.00006809377,0.00010899738,0.00032423012,0.0003654784],"category_scores_gemma":[0.0000053550375,0.0004821169,0.0006162263,0.00033769495,0.00019841961,0.00011401303,0.000007454388,0.00034137757,0.000014839856],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0018694964,0.0004981571,0.000012441499,0.0055365004,0.013299453,0.000058676716,0.0000550408,1.7326589e-7,0.000002910958,0.00015754411,0.00018457045,0.978325],"study_design_scores_gemma":[0.0051208683,0.0011029576,0.00024376475,0.0018378083,0.0028794752,0.000024189982,0.000056422745,0.000012266057,0.00004041191,0.00031748725,0.98788047,0.0004838847],"about_ca_topic_score_codex":0.000013133671,"about_ca_topic_score_gemma":0.000002709582,"teacher_disagreement_score":0.9876959,"about_ca_system_score_codex":0.000035218443,"about_ca_system_score_gemma":0.00062031636,"threshold_uncertainty_score":0.9997631},"labels":[],"label_agreement":null},{"id":"W4385828734","doi":"10.1038/s41392-023-01503-7","title":"The mitophagy pathway and its implications in human diseases","year":2023,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":768,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"Servier; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Mitophagy; Computational biology; Biology; Medicine; Genetics; Autophagy","score_opus":0.07304080255075136,"score_gpt":0.36050822580978376,"score_spread":0.2874674232590324,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385828734","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.002877596,0.99502844,0.000007558473,0.000292818,0.0001422365,0.0013302387,0.00013630615,0.00012977411,0.000055065677],"genre_scores_gemma":[0.004991411,0.99315035,0.0000034308334,0.00009572041,0.00032324748,0.00043364018,0.00024789447,0.00007356358,0.0006807316],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99845207,0.00017927129,0.00048366445,0.00044059558,0.00016266372,0.00028171664],"domain_scores_gemma":[0.9992231,0.00016441339,0.00012394552,0.00024609672,0.000046713496,0.0001957452],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015899849,0.0003519104,0.0007982129,0.00021679865,0.0003758154,0.000051015002,0.000105102634,0.00020498227,0.00015403231],"category_scores_gemma":[0.000008252869,0.00022425482,0.0002788161,0.00045217958,0.00013366112,0.00006717663,0.000009462329,0.0003506101,0.000013170167],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.000095571006,0.0001925485,0.000029887431,0.0019053705,0.00053581805,0.000025811732,0.00016218507,2.6655408e-7,0.00048287518,0.0033863392,0.000080336744,0.99310297],"study_design_scores_gemma":[0.0018853294,0.00030196772,0.0025104003,0.002051713,0.00035525678,0.0000781236,0.0000689521,0.0000065966146,0.00025913343,0.0036985779,0.9883745,0.00040950105],"about_ca_topic_score_codex":0.000008396344,"about_ca_topic_score_gemma":0.000004966821,"teacher_disagreement_score":0.9926935,"about_ca_system_score_codex":0.000034621244,"about_ca_system_score_gemma":0.00015819605,"threshold_uncertainty_score":0.9144846},"labels":[],"label_agreement":null},{"id":"W4385904643","doi":"10.1038/s41392-023-01539-9","title":"VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway","year":2023,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"State Key Laboratory of Ophthalmology; Novo Nordisk Fonden; National Natural Science Foundation of China-Yunnan Joint Fund; Sun Yat-sen University; National Natural Science Foundation of China","keywords":"Angiogenesis; Fibroblast growth factor receptor 1; Cancer research; MAPK/ERK pathway; In vivo; Fibroblast growth factor; Function (biology); VEGF receptors; Vascular endothelial growth factor; Biology; Medicine; Pharmacology; Chemistry; Cell biology; Signal transduction; Internal medicine; Receptor; Genetics","score_opus":0.01602937425335377,"score_gpt":0.258292156353639,"score_spread":0.24226278210028523,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4385904643","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9965304,0.0020419455,0.00062414096,0.00021225598,0.00010235927,0.000246514,0.000086149346,0.00006533012,0.0000909126],"genre_scores_gemma":[0.9970441,0.0014322094,0.0000587468,0.00007961557,0.00019494045,0.000046062018,0.0004250478,0.00003980952,0.00067950814],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99875546,0.00012957957,0.00017498697,0.00039810734,0.00020936101,0.00033252183],"domain_scores_gemma":[0.999645,0.000014123831,0.000046353216,0.00011920254,0.000057968682,0.0001173538],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019076456,0.00017489538,0.00012960761,0.000098501856,0.00016401008,0.00003515245,0.00010273147,0.00014622817,0.00019560315],"category_scores_gemma":[0.000009309777,0.00016415912,0.00010021809,0.0003011043,0.00008570936,0.000011979439,0.000021434458,0.000103971004,0.000020299442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001617347,0.000042780484,0.0009986139,0.000019133286,0.000083363215,0.000003057299,0.00015639269,0.000018097391,0.98605925,0.000007993459,0.0012004443,0.011249158],"study_design_scores_gemma":[0.000880904,0.00034221084,0.001588454,0.00001579753,0.0000038532667,0.000007372707,0.0001297663,0.000037697544,0.98433954,0.00011323222,0.012347124,0.00019405485],"about_ca_topic_score_codex":0.000015788715,"about_ca_topic_score_gemma":0.000002189778,"teacher_disagreement_score":0.0111466795,"about_ca_system_score_codex":0.000008972316,"about_ca_system_score_gemma":0.000040866325,"threshold_uncertainty_score":0.66942143},"labels":[],"label_agreement":null},{"id":"W4386446579","doi":"10.1038/s41392-023-01589-z","title":"Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials","year":2023,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":344,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Chengdu University; Jiangxi University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine; National Natural Science Foundation of China","keywords":"Drug discovery; Computational biology; Drug development; Biology; Drug; Bioinformatics; Pharmacology","score_opus":0.10587808234564951,"score_gpt":0.4042721095420451,"score_spread":0.29839402719639563,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4386446579","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0006150981,0.9942813,0.0007180621,0.0005121008,0.0010813012,0.0025528942,0.00017266066,0.000036109344,0.00003049336],"genre_scores_gemma":[0.00011425183,0.9957568,0.0001794005,0.0002418838,0.00178765,0.00057369,0.0008670054,0.000065701424,0.00041360882],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99497056,0.0023295267,0.0014309529,0.0007601105,0.0002219983,0.0002868465],"domain_scores_gemma":[0.99887365,0.00024634265,0.00040894822,0.00029886077,0.00005662762,0.0001155595],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0034627644,0.00040355462,0.0011691925,0.00012844999,0.00014226261,0.00010699687,0.0002697709,0.0003338964,0.00013007157],"category_scores_gemma":[0.00037958566,0.00025324218,0.0004913758,0.00042776825,0.000099648,0.000027359534,0.000035755533,0.00046973594,0.000020153051],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002006468,0.0000707702,0.000007046134,0.00021325941,0.00016955323,0.000001598282,0.00006577692,0.000009281376,0.0011069532,0.000017922515,0.0010818104,0.99705535],"study_design_scores_gemma":[0.000630416,0.0001506779,0.0000048877673,0.0008850107,0.000052324012,0.000001571676,0.00011981457,0.0000027028298,0.0027417038,0.00019798716,0.9948865,0.00032639643],"about_ca_topic_score_codex":0.000027925462,"about_ca_topic_score_gemma":0.00005115883,"teacher_disagreement_score":0.99672896,"about_ca_system_score_codex":0.000022740955,"about_ca_system_score_gemma":0.0001967732,"threshold_uncertainty_score":0.99999195},"labels":[],"label_agreement":null},{"id":"W4389030365","doi":"10.1038/s41392-023-01655-6","title":"Signaling pathways and targeted therapies for psoriasis","year":2023,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":360,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China","keywords":"Psoriasis; Disease; Mechanism (biology); Medicine; Epigenetics; Pathogenesis; Bioinformatics; Intensive care medicine; Immunology; Biology; Pathology; Genetics","score_opus":0.08059675380004618,"score_gpt":0.2949508710315138,"score_spread":0.21435411723146763,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4389030365","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0016171759,0.9938353,0.00026845757,0.000051682702,0.0014243167,0.0016379969,0.00081854966,0.0003264332,0.000020093326],"genre_scores_gemma":[0.0011472586,0.9950963,0.00020086036,0.00003945047,0.00032876967,0.00068026193,0.0016468472,0.00014126855,0.0007189457],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9974711,0.00047226177,0.0006534433,0.00080842315,0.000065505024,0.0005292721],"domain_scores_gemma":[0.9988667,0.00048699143,0.00027313863,0.00022762144,0.000080972844,0.00006457816],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00043764524,0.00075123465,0.0016062986,0.0003974921,0.00054472964,0.000061135455,0.00016683275,0.0008607189,0.0005852537],"category_scores_gemma":[0.000012486308,0.0005718656,0.000611955,0.0003608765,0.00020562766,0.0001146538,0.000014247132,0.00032966028,0.000059176604],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00028911134,0.000095091564,0.0000033395133,0.0014620668,0.0033356352,0.000003865139,0.00091891526,4.808255e-7,0.008507605,0.00030857197,0.00018161105,0.9848937],"study_design_scores_gemma":[0.0031684856,0.00059148984,0.000017351926,0.001029265,0.0012910429,0.00006718508,0.0003257493,0.0000012180658,0.0052205464,0.0011012476,0.98641205,0.0007743478],"about_ca_topic_score_codex":0.000020332815,"about_ca_topic_score_gemma":0.000004688184,"teacher_disagreement_score":0.98623043,"about_ca_system_score_codex":0.00003288289,"about_ca_system_score_gemma":0.000109816145,"threshold_uncertainty_score":0.9996733},"labels":[],"label_agreement":null},{"id":"W4390599722","doi":"10.1038/s41392-023-01687-y","title":"The role of inflammasomes in human diseases and their potential as therapeutic targets","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":218,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Inflammasome; Innate immune system; AIM2; Pyroptosis; Effector; Disease; Inflammation; Biology; Caspase 1; Medicine; Immunology; Cancer research; Immune system; Pathology","score_opus":0.0038647388608716872,"score_gpt":0.218801009814542,"score_spread":0.21493627095367032,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4390599722","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8421691,0.157161,0.000094386516,0.00018311596,0.00009427297,0.000148637,0.000009274605,0.000012549607,0.00012768396],"genre_scores_gemma":[0.9847467,0.01494541,0.0000037648406,0.00004378658,0.00008590877,0.00001908772,0.00004465111,0.000016228229,0.00009444858],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9993496,0.0000696067,0.00016653768,0.00020025254,0.00006243354,0.00015155926],"domain_scores_gemma":[0.9998114,0.000011822093,0.000024451589,0.00009725443,0.000024960544,0.000030072197],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010230829,0.00013320516,0.00010589912,0.00005699683,0.00013204703,0.00004295596,0.000066787645,0.00007368931,0.000057411016],"category_scores_gemma":[0.0000018530594,0.0000876156,0.0000749302,0.00008213234,0.00017353632,0.00001156127,0.0000095208625,0.00008599241,6.436812e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00020500891,0.000029838819,0.00065693195,0.000011448903,0.00012066398,9.0766804e-7,0.0006011669,0.000016337252,0.92210495,0.0009396927,0.000007814292,0.07530526],"study_design_scores_gemma":[0.0008405349,0.00047462527,0.007585194,0.000019100753,0.0000151741215,0.000012277827,0.0021453656,0.00017268912,0.91868657,0.01495724,0.05489512,0.00019610312],"about_ca_topic_score_codex":0.000020899482,"about_ca_topic_score_gemma":0.000010587629,"teacher_disagreement_score":0.14257763,"about_ca_system_score_codex":0.0000028363124,"about_ca_system_score_gemma":0.000029847104,"threshold_uncertainty_score":0.35728604},"labels":[],"label_agreement":null},{"id":"W4391108440","doi":"10.1038/s41392-023-01733-9","title":"Correction: Signaling pathways and targeted therapies for psoriasis","year":2024,"lang":"en","type":"erratum","venue":"Signal Transduction and Targeted Therapy","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"","keywords":"Psoriasis; Computational biology; Medicine; Bioinformatics; Biology; Dermatology","score_opus":0.03140891528325305,"score_gpt":0.24320534178558184,"score_spread":0.2117964265023288,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4391108440","genre_codex":"review","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.249814,0.5651537,0.0054368875,0.0057297894,0.13380636,0.0033180465,0.0047480767,0.003935383,0.0280577],"genre_scores_gemma":[0.84717774,0.06551984,0.0006557122,0.00044563782,0.014515414,0.00062205346,0.0017230961,0.00030592817,0.069034584],"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","domain_scores_codex":[0.9978194,0.00008617947,0.0004399272,0.00096879964,0.00026289752,0.00042278392],"domain_scores_gemma":[0.9990413,0.00031674156,0.00017397416,0.0001938032,0.00012258007,0.00015158874],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003073095,0.00064125995,0.0007310796,0.00013894697,0.00039707628,0.00021544094,0.00014370217,0.0010424736,0.003851562],"category_scores_gemma":[0.000029224128,0.00047456456,0.0003838901,0.00018272542,0.00021174684,0.00012579688,0.000015327088,0.0009854115,0.0000057924804],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0010153578,0.0002567779,0.000035213987,0.0006302324,0.0012613235,0.000008230917,0.0011021638,0.0000037195687,0.6269928,0.00015646196,0.100164,0.2683737],"study_design_scores_gemma":[0.00091986096,0.0003662673,0.000077057986,0.00030848267,0.00017612906,0.000036126832,0.0007032649,0.0005103485,0.23273955,0.0047496655,0.7585861,0.0008271142],"about_ca_topic_score_codex":0.00003823854,"about_ca_topic_score_gemma":0.000008523897,"teacher_disagreement_score":0.6584221,"about_ca_system_score_codex":0.0000493624,"about_ca_system_score_gemma":0.00008523189,"threshold_uncertainty_score":0.9997706},"labels":[],"label_agreement":null},{"id":"W4392477241","doi":"10.1038/s41392-024-01768-6","title":"Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of British Columbia","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"ADAM10; Amyloid precursor protein; Ectodomain; Amyloid precursor protein secretase; Presenilin; Furin; Phenotype; Biology; Cleavage (geology); Cell biology; Genetics; Gene; Metalloproteinase; Biochemistry; Alzheimer's disease; Medicine; Enzyme; Receptor","score_opus":0.026161789416370453,"score_gpt":0.2920226205486933,"score_spread":0.2658608311323229,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4392477241","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.964015,0.0021177016,0.006366706,0.023217825,0.0009749483,0.0020062726,0.000119303855,0.00072857126,0.00045367464],"genre_scores_gemma":[0.9973143,0.00030115867,0.000051204603,0.0007130928,0.000104314255,0.00017257426,0.000030611594,0.00006461061,0.0012481727],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9974325,0.00046416806,0.00031011074,0.00069653033,0.0005359587,0.00056074694],"domain_scores_gemma":[0.9992979,0.00021930017,0.000054082677,0.00021595643,0.00002219161,0.00019056188],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003985125,0.00028047035,0.00022662799,0.0002615923,0.0007905058,0.0004066174,0.0002635247,0.00011214971,0.0015898324],"category_scores_gemma":[0.00004042716,0.00021478078,0.00013843189,0.0011168753,0.00024398272,0.00038423383,0.000023112276,0.0005879846,0.00017394728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00029843007,0.00016013587,0.000025348916,0.000026180776,0.00009191154,0.000044379776,0.004376073,0.00011067421,0.9656022,0.01452516,0.0003552994,0.014384186],"study_design_scores_gemma":[0.0024541891,0.0012248568,0.0019322998,0.00012556108,0.00006969219,0.000092400995,0.0009909412,0.0052637677,0.91678023,0.02234409,0.04782708,0.0008948678],"about_ca_topic_score_codex":0.00020961328,"about_ca_topic_score_gemma":0.0001020758,"teacher_disagreement_score":0.048821967,"about_ca_system_score_codex":0.00007945971,"about_ca_system_score_gemma":0.00013719198,"threshold_uncertainty_score":0.99932283},"labels":[],"label_agreement":null},{"id":"W4392757206","doi":"10.1038/s41392-024-01769-5","title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","year":2024,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":714,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China","keywords":"Cancer; Cancer research; Cancer cell; Tumor microenvironment; Immunotherapy; Biology; Immunology; Medicine; Genetics","score_opus":0.06071929866109995,"score_gpt":0.35724796874722786,"score_spread":0.29652867008612793,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4392757206","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0007616188,0.9942846,0.0011795807,0.0009937709,0.00053627905,0.0018667447,0.00014230353,0.0001284681,0.00010666288],"genre_scores_gemma":[0.012860688,0.98442644,0.0003006043,0.0005909361,0.00024954695,0.0012377142,0.00013101805,0.00012850083,0.00007456715],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.9977535,0.00016356452,0.0005958783,0.0007952039,0.00034056473,0.00035127052],"domain_scores_gemma":[0.9993857,0.000025208565,0.000088203466,0.00025115107,0.000053713862,0.00019603701],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00016378866,0.00059692835,0.0015523146,0.000468921,0.0000539502,0.00011895638,0.00012596502,0.00037581817,0.0015661039],"category_scores_gemma":[0.0000012860627,0.00043334952,0.00049677864,0.0008244067,0.00005017851,0.00008717802,0.000011887707,0.00060983264,0.00003288794],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0001499145,0.00016092582,0.0000018159423,0.0026210286,0.0010313232,0.000036780133,0.000491256,0.0000071083127,0.0041597085,0.00077302306,0.000071850955,0.99049526],"study_design_scores_gemma":[0.0013449958,0.0010804213,0.000030478017,0.015139639,0.0026686385,0.00003727245,0.0006082806,0.00003055346,0.00454801,0.0038909991,0.9696568,0.00096386235],"about_ca_topic_score_codex":0.00046442944,"about_ca_topic_score_gemma":0.000041647072,"teacher_disagreement_score":0.9895314,"about_ca_system_score_codex":0.00015184165,"about_ca_system_score_gemma":0.0004167183,"threshold_uncertainty_score":0.9998118},"labels":[],"label_agreement":null},{"id":"W4392771886","doi":"10.1038/s41392-024-01752-0","title":"Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Cytotoxic T cell; CD8; Immunology; Eosinophil; Adoptive cell transfer; Biology; Immune system; T cell; Memory T cell; Cell biology; In vitro","score_opus":0.017204370703185246,"score_gpt":0.23129469086468013,"score_spread":0.21409032016149487,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4392771886","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9770283,0.005624969,0.0037537948,0.00078454067,0.011538787,0.00045310857,0.000016872958,0.00026784505,0.00053175713],"genre_scores_gemma":[0.9930284,0.0008069007,0.00006925054,0.00027176098,0.00034496994,0.000029023851,0.00044551262,0.000031874835,0.004972318],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.998761,0.00024695293,0.0003040395,0.00037844817,0.000050881812,0.00025869603],"domain_scores_gemma":[0.9996642,0.000018409637,0.00004380862,0.00015535782,0.00007883222,0.00003940542],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00024184832,0.00022860944,0.0002062618,0.00023603301,0.00033234814,0.00011646163,0.00007931671,0.00020870587,0.007722575],"category_scores_gemma":[0.000003423431,0.00020148726,0.00012398223,0.0001697195,0.00006772122,0.0003226695,0.000009620584,0.00036630224,0.0005043645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003676673,0.0001202419,0.000004288039,0.000019629431,0.00013563389,0.0000025334398,0.000991934,0.000035570312,0.96924764,0.000075446325,0.0024491567,0.026550272],"study_design_scores_gemma":[0.000870837,0.00042089395,0.00025276782,0.000022010343,0.000027332355,0.000057868845,0.00012912144,0.00008616841,0.84620255,0.00004330503,0.15167937,0.00020776714],"about_ca_topic_score_codex":0.00007816234,"about_ca_topic_score_gemma":0.0000032458563,"teacher_disagreement_score":0.14923021,"about_ca_system_score_codex":0.00003372863,"about_ca_system_score_gemma":0.000041630363,"threshold_uncertainty_score":0.9931845},"labels":[],"label_agreement":null},{"id":"W4393515970","doi":"10.1038/s41392-024-01815-2","title":"Optimizing oncolytic virus design: a “Swiss army knife” approach to create a systemically delivered therapeutic","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Ottawa Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Oncolytic virus; Virology; Virus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Coronavirus disease 2019 (COVID-19); Viral therapy; Pathology","score_opus":0.03715177940766257,"score_gpt":0.2889530140764563,"score_spread":0.2518012346687937,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4393515970","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.59584415,0.06346006,0.33672464,0.0007246742,0.00033485098,0.0020856971,0.000048525504,0.00026429672,0.00051314203],"genre_scores_gemma":[0.9921381,0.0032882479,0.0029177242,0.00050972064,0.0003469108,0.00021969834,0.0000574367,0.00008824763,0.00043391614],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99782556,0.0003555282,0.00030880916,0.0007545977,0.00029661198,0.00045887323],"domain_scores_gemma":[0.99929005,0.000032958837,0.00003304387,0.00028758467,0.000104578205,0.00025179796],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005476239,0.00033510043,0.00027355857,0.00019460566,0.0001748927,0.00016529669,0.00022284721,0.0002124047,0.00015360315],"category_scores_gemma":[0.0000049835244,0.00028971996,0.00016784688,0.00038926688,0.00010313461,0.000015711843,0.000018938465,0.00024788256,0.000028630286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0049587656,0.00015042367,0.0000028765273,0.0000745762,0.00043792927,0.000007898285,0.00075950567,0.0030715766,0.970723,0.00007210495,0.00012836691,0.01961302],"study_design_scores_gemma":[0.0016308137,0.004701531,0.000024388279,0.000087180066,0.000048521604,0.00009908119,0.00025040502,0.0068996414,0.9788314,0.00036164143,0.0065372526,0.00052815134],"about_ca_topic_score_codex":0.000025632135,"about_ca_topic_score_gemma":0.000006891304,"teacher_disagreement_score":0.39629397,"about_ca_system_score_codex":0.000049316695,"about_ca_system_score_gemma":0.00017725151,"threshold_uncertainty_score":0.9999555},"labels":[],"label_agreement":null},{"id":"W4394060597","doi":"10.1038/s41392-024-01801-8","title":"The gasdermin family: emerging therapeutic targets in diseases","year":2024,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Pyroptosis; Effector; Disease; Inflammasome; Medicine; Computational biology; Biology; Bioinformatics; Immunology; Inflammation; Pathology","score_opus":0.02081046558491485,"score_gpt":0.29792936988233265,"score_spread":0.2771189042974178,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4394060597","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.000227849,0.998362,0.000093847295,0.000078733174,0.0005246628,0.00053971214,0.00003316751,0.000026127676,0.000113902715],"genre_scores_gemma":[0.0020027577,0.99658775,0.000006938063,0.000102443606,0.00025968833,0.0001667452,0.00035307868,0.00007260157,0.00044799972],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99841404,0.00023018166,0.00041542907,0.0004757002,0.00012747923,0.0003371939],"domain_scores_gemma":[0.9995698,0.000021748954,0.00008366309,0.00024405573,0.000028342913,0.000052426218],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001965466,0.00041255035,0.00048741314,0.00012862416,0.00019267086,0.000082824234,0.00019246971,0.00024650185,0.00004944867],"category_scores_gemma":[0.000004364045,0.0002619018,0.00040262344,0.00024849107,0.0001347929,0.0000070305077,0.000019228084,0.00031634717,0.000013035449],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00006887299,0.00004002382,0.0000028163856,0.0005667816,0.00036851128,0.0000048191064,0.00013417768,0.0000023838231,0.0021056307,0.00007948956,0.00029600674,0.9963305],"study_design_scores_gemma":[0.00033633897,0.00012654028,0.000011500552,0.00038495028,0.00016305357,0.000012650243,0.00024833914,0.000007309115,0.00034651908,0.00028534228,0.99774426,0.0003332065],"about_ca_topic_score_codex":0.000007143534,"about_ca_topic_score_gemma":0.000009441165,"teacher_disagreement_score":0.99744827,"about_ca_system_score_codex":0.00001472412,"about_ca_system_score_gemma":0.00014397937,"threshold_uncertainty_score":0.9999833},"labels":[],"label_agreement":null},{"id":"W4399711928","doi":"10.1038/s41392-024-01862-9","title":"Targeted therapy for capillary-venous malformations","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Vascular Malformations and Hemangiomas","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Agence Nationale de la Recherche","keywords":"Medicine; Venous malformation; Vascular malformation; Magnetic resonance imaging; Venous thrombosis; Pathology; Internal medicine; Radiology; Surgery; Thrombosis","score_opus":0.023182760907728955,"score_gpt":0.2715170917828398,"score_spread":0.24833433087511084,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4399711928","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.83812726,0.08624684,0.061755463,0.007991399,0.0009421518,0.002789004,0.00013711616,0.00081602973,0.001194773],"genre_scores_gemma":[0.98639184,0.009554682,0.0018740472,0.0005735986,0.00038043625,0.00018062168,0.0004085827,0.00004854529,0.000587659],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99895155,0.00003090762,0.0003049001,0.00025405624,0.00019467674,0.00026389587],"domain_scores_gemma":[0.999528,0.000033468117,0.00003210255,0.00015704696,0.00012221113,0.00012717568],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00022226137,0.00020527498,0.00025738802,0.000294391,0.0002789259,0.00008473721,0.000047023004,0.00012882787,0.0013355006],"category_scores_gemma":[0.0000032580476,0.00016040185,0.0002825598,0.00035503204,0.00006595511,0.00030494705,0.000002652999,0.00016569918,0.000029503375],"study_design_candidate":"not_applicable","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0024050605,0.0014448459,0.00026450655,0.00094875385,0.0031123045,0.00004500686,0.020567736,0.00019016294,0.44947475,0.027155576,0.00951078,0.48488054],"study_design_scores_gemma":[0.008099304,0.00300908,0.004434829,0.00017120237,0.0002049059,0.000657362,0.0013006785,0.01059391,0.12223451,0.0053780735,0.8432544,0.00066175836],"about_ca_topic_score_codex":0.000016631659,"about_ca_topic_score_gemma":0.0000024018584,"teacher_disagreement_score":0.83374363,"about_ca_system_score_codex":0.000030419542,"about_ca_system_score_gemma":0.000094347655,"threshold_uncertainty_score":0.9995774},"labels":[],"label_agreement":null},{"id":"W4401806042","doi":"10.1038/s41392-024-01930-0","title":"Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Windsor","funders":"Guangzhou Municipal Science and Technology Project; Peking University; National Natural Science Foundation of China","keywords":"Adipogenesis; Annexin A1; Adipocyte; Adipose tissue; Cell biology; Cancer research; Internal medicine; Biology; Endocrinology; Chemistry; Annexin; Medicine; Biochemistry; Apoptosis","score_opus":0.00891411651861381,"score_gpt":0.235291345552783,"score_spread":0.22637722903416918,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4401806042","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97621095,0.02041684,0.0020325764,0.0007984834,0.0001166722,0.00028445025,0.00003606175,0.000031926997,0.000072009374],"genre_scores_gemma":[0.9939249,0.0045800246,0.00047482608,0.0003017462,0.00024542946,0.00003242067,0.00003253133,0.000022994287,0.00038508774],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99913806,0.000059734062,0.00013433082,0.00041523486,0.000079310295,0.00017334064],"domain_scores_gemma":[0.99971765,0.000006133447,0.000015168236,0.000095984826,0.000024886853,0.00014015738],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016907843,0.0001675129,0.0001259196,0.0000791063,0.00011940506,0.0000692914,0.00003998859,0.00011917607,0.00011452687],"category_scores_gemma":[0.0000022090157,0.00014388618,0.000052338546,0.00011967907,0.000071567396,0.000010512408,0.000016473234,0.00007662219,0.0000026351872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00017961056,0.00006182873,0.0003584295,0.000034739238,0.00008340836,0.0000046645246,0.0003725334,0.0000054289476,0.96059793,0.00018362787,0.00018645487,0.037931353],"study_design_scores_gemma":[0.0007259633,0.0011710947,0.0047144988,0.00004973368,0.000021245094,0.00006184202,0.00021544097,0.000044522676,0.8917628,0.0010108576,0.099894695,0.00032732642],"about_ca_topic_score_codex":0.000021119333,"about_ca_topic_score_gemma":0.00001487787,"teacher_disagreement_score":0.09970824,"about_ca_system_score_codex":0.000005360889,"about_ca_system_score_gemma":0.000025396454,"threshold_uncertainty_score":0.5867508},"labels":[],"label_agreement":null},{"id":"W4402325703","doi":"10.1038/s41392-024-01935-9","title":"Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours","year":2024,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"Genentech; Innovative Medicines Initiative; Deutsche Forschungsgemeinschaft; Deutschen Konsortium für Translationale Krebsforschung; European Federation of Pharmaceutical Industries and Associations; Genome Canada; McGill University; Deutsche Krebshilfe; Pfizer","keywords":"Mutant; SWI/SNF; Cancer research; Biology; Computational biology; Medicine; Chemistry; Genetics; Gene; Transcription factor","score_opus":0.031889028273389554,"score_gpt":0.27551379855633373,"score_spread":0.2436247702829442,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402325703","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.5934191,0.112476334,0.021103343,0.2669731,0.0013058664,0.002003591,0.0022582377,0.00019387557,0.00026656978],"genre_scores_gemma":[0.9552336,0.007854889,0.0003722472,0.027266514,0.0028947338,0.00008274481,0.00411525,0.00012508924,0.0020549812],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9980868,0.00024658817,0.00054927805,0.0005208834,0.00032357578,0.0002728496],"domain_scores_gemma":[0.99911666,0.000023801684,0.00042618415,0.00018000565,0.0001778735,0.00007548003],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00028553547,0.0003750421,0.0004374792,0.00009161875,0.00010156297,0.0000507853,0.00013656475,0.0005122263,0.00020543547],"category_scores_gemma":[0.000017120876,0.00033530217,0.00022502198,0.00007731609,0.00017290516,0.000009579545,0.000010264882,0.0005041813,0.0000013710468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00025474123,0.000029595414,0.0000032978692,0.00023838626,0.0002392058,0.000008624193,0.00020127415,0.00003646282,0.87251174,0.000017945264,0.119737305,0.0067213983],"study_design_scores_gemma":[0.0014263877,0.00048305906,0.000010924232,0.00025820397,0.00007251319,0.000020562014,0.00028723443,0.00014212744,0.76556075,0.00089130964,0.23036547,0.00048148015],"about_ca_topic_score_codex":0.00016354663,"about_ca_topic_score_gemma":0.0000043764426,"teacher_disagreement_score":0.36181447,"about_ca_system_score_codex":0.000021798918,"about_ca_system_score_gemma":0.00020190161,"threshold_uncertainty_score":0.9999099},"labels":[],"label_agreement":null},{"id":"W4402384263","doi":"10.1038/s41392-024-01943-9","title":"Anti-PD-L1 antibody ASC22 in combination with a histone deacetylase inhibitor chidamide as a “shock and kill” strategy for ART-free virological control: a phase II single-arm study","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"CD8; Histone deacetylase inhibitor; Antibody; Immunology; Viral load; Biology; Immunity; Medicine; Human immunodeficiency virus (HIV); Virology; Internal medicine; Immune system; Histone deacetylase; Histone; DNA","score_opus":0.02095275379809334,"score_gpt":0.3093826573121055,"score_spread":0.28842990351401215,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4402384263","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9865726,0.008875422,0.0012682923,0.0009898256,0.0001343795,0.0018173223,0.00017248085,0.0001073939,0.00006224918],"genre_scores_gemma":[0.99842966,0.0004997045,0.000039787046,0.000064778156,0.000035413068,0.00022140575,0.00039388757,0.000024431522,0.00029092023],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99849254,0.00027599366,0.00027759894,0.0005103186,0.00008073841,0.00036283664],"domain_scores_gemma":[0.999573,0.00012377123,0.000042670326,0.00013733018,0.000055986056,0.000067244764],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029185147,0.00026376318,0.00038280926,0.0002532977,0.00027892692,0.000058924674,0.00007570666,0.00016385292,0.00038923847],"category_scores_gemma":[0.000013462759,0.00018872834,0.0000689234,0.00021041677,0.00026051575,0.00017435722,0.000010493239,0.00031100347,0.000015494132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.013146616,0.012248505,0.00049948046,0.000040872852,0.0008265726,0.00013009788,0.0017727579,0.00001965935,0.9426949,0.0005709601,0.00017066197,0.027878886],"study_design_scores_gemma":[0.29509088,0.31314874,0.026238786,0.0002631639,0.0004911843,0.0009181939,0.0034525758,0.0007046087,0.32928714,0.0054418254,0.023458514,0.0015044087],"about_ca_topic_score_codex":0.000060315524,"about_ca_topic_score_gemma":0.00006779372,"teacher_disagreement_score":0.6134078,"about_ca_system_score_codex":0.00004664106,"about_ca_system_score_gemma":0.000074629905,"threshold_uncertainty_score":0.76961184},"labels":[],"label_agreement":null},{"id":"W4404580565","doi":"10.1038/s41392-024-02028-3","title":"Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"Zhejiang University; Tianjin University; East China Normal University; National Natural Science Foundation of China","keywords":"Stage (stratigraphy); Tumor microenvironment; Solid tumor; Cancer research; Bacteria; Pathology; Biology; Medicine; Tumor cells; Cancer; Internal medicine; Genetics","score_opus":0.009941144038593787,"score_gpt":0.2591646144530536,"score_spread":0.24922347041445983,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4404580565","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97637534,0.022365257,0.0002268033,0.00024083143,0.00012637059,0.00045837497,0.000108200344,0.000016003256,0.00008280921],"genre_scores_gemma":[0.9809996,0.017731946,0.00008537145,0.0001951665,0.00008297908,0.00008950574,0.00017690015,0.000030323332,0.0006081913],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9989269,0.00009128783,0.00016631575,0.0003994293,0.00013591598,0.00028018412],"domain_scores_gemma":[0.9997377,0.000008158874,0.000029674271,0.00013782423,0.00001158033,0.00007509222],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012270159,0.00019143122,0.00012519534,0.000050557766,0.00010586405,0.000060735438,0.00009448155,0.000049705657,0.00040046827],"category_scores_gemma":[8.034413e-7,0.00013631527,0.00007693204,0.00010855324,0.000092555565,0.000014954934,0.0000116332685,0.00014453137,0.0000059167623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0006821354,0.00012672982,0.0002992595,0.000010790085,0.00009000919,0.000014096665,0.00027276904,0.000051740044,0.9783002,0.000004279391,0.0002570014,0.019890953],"study_design_scores_gemma":[0.0016877142,0.0007736812,0.0011767411,0.000022034214,0.000003838318,0.00001009223,0.0002262714,0.000046695342,0.9228497,0.000044296536,0.07300283,0.00015606651],"about_ca_topic_score_codex":0.00007303787,"about_ca_topic_score_gemma":0.000015046615,"teacher_disagreement_score":0.07274583,"about_ca_system_score_codex":0.000043726875,"about_ca_system_score_gemma":0.000043682045,"threshold_uncertainty_score":0.5558775},"labels":[],"label_agreement":null},{"id":"W4405825076","doi":"10.1038/s41392-024-02077-8","title":"Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Key Research and Development Program of China; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China","keywords":"Rab; GTPase; Biology; Cell biology","score_opus":0.020108319592946528,"score_gpt":0.23886831399053277,"score_spread":0.21875999439758623,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405825076","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97933066,0.017315362,0.0010073504,0.001279674,0.00047191532,0.0002419819,0.000012878104,0.00013740463,0.00020277491],"genre_scores_gemma":[0.99725854,0.002124874,0.000011965224,0.00014661557,0.000055612898,0.000023487271,0.00006405997,0.000016115688,0.000298747],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9990386,0.00024094128,0.00021401008,0.00027801518,0.000040891933,0.00018759212],"domain_scores_gemma":[0.99966353,0.00016427282,0.00003873582,0.00008746409,0.00002874655,0.000017260412],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000374398,0.00017460932,0.00016088742,0.000112457834,0.00038836058,0.00006107758,0.000035257886,0.00013357942,0.0006174069],"category_scores_gemma":[0.000008597204,0.00011676929,0.000076550896,0.00013637992,0.0001638435,0.0002118779,0.0000057792067,0.00030106676,0.000028010163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00022375824,0.000025144047,0.0001535942,0.000018652901,0.00018952717,9.1395816e-7,0.0015213417,0.00004352237,0.88734555,0.0014917175,0.000036226986,0.10895003],"study_design_scores_gemma":[0.0014821499,0.00069307577,0.0069284756,0.00010245826,0.000047210695,0.00009422702,0.00031817617,0.0016021658,0.9541042,0.0030559765,0.031275783,0.00029614198],"about_ca_topic_score_codex":0.000064904074,"about_ca_topic_score_gemma":0.0000021287744,"teacher_disagreement_score":0.10865389,"about_ca_system_score_codex":0.000016404929,"about_ca_system_score_gemma":0.000013855623,"threshold_uncertainty_score":0.6760172},"labels":[],"label_agreement":null},{"id":"W4405877673","doi":"10.1038/s41392-024-02076-9","title":"Malate initiates a proton-sensing pathway essential for pH regulation of inflammation","year":2024,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"route_ca_aff":false,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; Army Medical University; Centre Scientifique et Technique du Bâtiment; National Institutes of Health; York University; Southwest Hospital; Fudan University; School of Pharmacy, Fudan University; National Natural Science Foundation of China; Chongqing Medical University; Wuhan University; NYU Langone Medical Center","keywords":"Cytosol; Biochemistry; Malate dehydrogenase; Chemistry; Signal transduction; Inflammation; Metabolite; In vitro; Downregulation and upregulation; Cell biology; Biology; Enzyme","score_opus":0.012533037968728929,"score_gpt":0.24868449155831732,"score_spread":0.2361514535895884,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4405877673","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.932431,0.003143915,0.063439324,0.00010134683,0.00028629883,0.000511857,0.000020293064,0.000029682815,0.000036294503],"genre_scores_gemma":[0.9975245,0.0006424663,0.0008455998,0.000020287436,0.00069515215,0.000028516688,0.00018037896,0.000020887492,0.000042192536],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9993416,0.000042054373,0.00020750602,0.00021565631,0.00008133425,0.00011186018],"domain_scores_gemma":[0.9997594,0.000012382809,0.00004749758,0.00006937041,0.00008184479,0.000029505863],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020381232,0.000107655076,0.00011129915,0.000077412515,0.00006819163,0.000034613542,0.000028745118,0.00009769407,0.000044342305],"category_scores_gemma":[0.0000065571876,0.00009697486,0.00008705536,0.00009223898,0.000045803015,0.000016603626,0.0000033582962,0.000047193666,4.7210872e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0003120085,0.000011103647,0.00002205995,0.00009742846,0.00006900489,2.517671e-7,0.00035375878,0.00016125407,0.9597953,0.00043614322,0.00000859721,0.038733117],"study_design_scores_gemma":[0.00071845663,0.00015442997,0.00023597268,0.00004026606,0.000016272255,0.000007967681,0.00005509528,0.0030647344,0.98465055,0.0013468872,0.009597972,0.00011141521],"about_ca_topic_score_codex":0.00000543277,"about_ca_topic_score_gemma":0.0000010909794,"teacher_disagreement_score":0.06509353,"about_ca_system_score_codex":0.0000029022258,"about_ca_system_score_gemma":0.000039850864,"threshold_uncertainty_score":0.395452},"labels":[],"label_agreement":null},{"id":"W4407778494","doi":"10.1038/s41392-025-02133-x","title":"Precise targeting of transcriptional co-activators YAP/TAZ annihilates chemoresistant brCSCs by alteration of their mitochondrial homeostasis","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":true,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; All-India Institute of Medical Sciences; University of Calcutta; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Homeostasis; Cancer research; Mitochondrion; Medicine; Cell biology; Chemistry; Biology","score_opus":0.009128353143895129,"score_gpt":0.24227321224149345,"score_spread":0.23314485909759833,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4407778494","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.97831374,0.008341319,0.012121722,0.00016347985,0.00024688328,0.00029644315,0.0003814768,0.000020485222,0.00011446356],"genre_scores_gemma":[0.9964462,0.0019407121,0.00055989577,0.00005814217,0.00014078806,0.000022657261,0.0006749302,0.000020576274,0.00013612662],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99870753,0.00012993881,0.00044243303,0.00036061063,0.00016798964,0.00019147915],"domain_scores_gemma":[0.9994694,0.000027042968,0.00014183948,0.00014338938,0.00015610662,0.00006222458],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019627552,0.00022373427,0.00028946728,0.00011002152,0.0001269292,0.00001891958,0.00010525795,0.00019481544,0.00014734497],"category_scores_gemma":[0.000011717119,0.00019918029,0.00017491503,0.00019147799,0.00016900155,0.000016473257,0.0000048672596,0.00011809614,3.3568386e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0014632012,0.00019542516,0.00018448719,0.00005825625,0.00021891166,2.3321448e-7,0.0004784336,0.00009130259,0.99026704,0.000079547375,0.00027830785,0.0066848667],"study_design_scores_gemma":[0.0015898586,0.00038320225,0.00023645813,0.000041049047,0.00002207105,0.0000017576151,0.00025117246,0.000092263115,0.9821093,0.00022667178,0.0148671735,0.00017898818],"about_ca_topic_score_codex":0.000021921134,"about_ca_topic_score_gemma":0.0000017416802,"teacher_disagreement_score":0.018132444,"about_ca_system_score_codex":0.000010317802,"about_ca_system_score_gemma":0.000092066526,"threshold_uncertainty_score":0.8122336},"labels":[],"label_agreement":null},{"id":"W4408082142","doi":"10.1038/s41392-025-02158-2","title":"Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activation","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Cancer research; Tumor microenvironment; Chimeric antigen receptor; Adoptive cell transfer; Immunology; Biology; Immune system; Immunotherapy; T cell","score_opus":0.00986634598711917,"score_gpt":0.24186419219480257,"score_spread":0.2319978462076834,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4408082142","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9836301,0.0038179753,0.007132051,0.0010170715,0.002928421,0.000793743,0.0000046223954,0.00018205434,0.0004939431],"genre_scores_gemma":[0.9938294,0.0006773591,0.00001887939,0.0008750588,0.000054336862,0.00005250329,0.0001514286,0.000027924509,0.0043130904],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99818754,0.00039025416,0.00050257606,0.00045540888,0.000059923976,0.00040430846],"domain_scores_gemma":[0.99944526,0.00011113236,0.000103834536,0.00019972066,0.000111421126,0.00002862342],"candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00025156283,0.0003137136,0.00037936293,0.0004864303,0.00029038827,0.000044752396,0.00012404603,0.0003077515,0.0031032017],"category_scores_gemma":[0.000008667812,0.00028975017,0.00014928635,0.00048731346,0.00017189521,0.0002731536,0.000010214894,0.0005637237,0.000065969456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0019800412,0.00036404553,0.00019632641,0.000022187267,0.00019932965,0.000002013654,0.0012809779,0.00015807466,0.95733196,0.00022676501,0.00040435756,0.037833903],"study_design_scores_gemma":[0.0046878327,0.00035236226,0.0074591488,0.00006329528,0.000026719577,0.000018682638,0.001327446,0.00015646513,0.9501045,0.0002897767,0.035226014,0.00028775207],"about_ca_topic_score_codex":0.00028930992,"about_ca_topic_score_gemma":0.000015003831,"teacher_disagreement_score":0.03754615,"about_ca_system_score_codex":0.00012451565,"about_ca_system_score_gemma":0.00010189657,"threshold_uncertainty_score":0.9999555},"labels":[],"label_agreement":null},{"id":"W4409113690","doi":"10.1038/s41392-025-02203-0","title":"Correction: LSD1 is required for euchromatic origin firing and replication timing","year":2025,"lang":"en","type":"erratum","venue":"Signal Transduction and Targeted Therapy","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Replication (statistics); Euchromatin; Computational biology; Computer science; Biology; Genetics; Virology; Gene","score_opus":0.024689115713346046,"score_gpt":0.28387351844271264,"score_spread":0.2591844027293666,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4409113690","genre_codex":"methods","genre_gemma":"other","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"other","genre_consensus":null,"domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.13413605,0.25416473,0.35687578,0.011169409,0.18394545,0.02029747,0.005342129,0.001884361,0.032184623],"genre_scores_gemma":[0.08995877,0.04571026,0.01340851,0.0033929646,0.00952974,0.0020029545,0.019506121,0.00041980247,0.81607085],"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","domain_scores_codex":[0.99862516,0.00005729971,0.00027322798,0.000730638,0.00011377117,0.00019988194],"domain_scores_gemma":[0.9993215,0.000023909208,0.00013758909,0.00034425588,0.00010816051,0.000064541084],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00019232734,0.0002769891,0.00026335407,0.00010478,0.00020817321,0.00005236234,0.000091695794,0.00047953686,0.00025172374],"category_scores_gemma":[0.000029640974,0.00028398534,0.00012511142,0.00011097372,0.0000580413,0.000009666185,0.0000128469765,0.00019893539,0.0000011301156],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0002590343,0.0000402434,0.0000041650364,0.00021242624,0.00024636576,5.4517176e-7,0.00019383682,0.0000042108004,0.44248098,0.00003319837,0.49774432,0.05878066],"study_design_scores_gemma":[0.0007818999,0.00044073045,0.00002817011,0.00016316569,0.00005774223,0.000024259327,0.000058725964,0.0010123355,0.28395948,0.0007336317,0.71243197,0.00030792528],"about_ca_topic_score_codex":0.000009053647,"about_ca_topic_score_gemma":0.000005734254,"teacher_disagreement_score":0.78388625,"about_ca_system_score_codex":0.00002242138,"about_ca_system_score_gemma":0.00011860261,"threshold_uncertainty_score":0.99996126},"labels":[],"label_agreement":null},{"id":"W4410198207","doi":"10.1038/s41392-025-02192-0","title":"The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer","year":2025,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Trace Elements in Health","field":"Nursing","cited_by":115,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SKiN Health","funders":"Xiangya Hospital, Central South University; National Natural Science Foundation of China","keywords":"Cancer; Cancer cell; Cancer therapy; Mechanism (biology); Biology; Cancer treatment; Metastasis; Computational biology; Bioinformatics; Cancer research; Medicine; Genetics","score_opus":0.03211555070330996,"score_gpt":0.34274612727121884,"score_spread":0.3106305765679089,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4410198207","genre_codex":"review","genre_gemma":"review","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"review","genre_consensus":"review","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.0028539887,0.99483216,0.000055778954,0.00057991507,0.0004623213,0.0011227777,0.000041345385,0.000024289664,0.000027405637],"genre_scores_gemma":[0.019677438,0.9798353,0.00006922093,0.00014386157,0.000046173704,0.00015410651,0.000010123893,0.000034573044,0.00002921616],"study_design_codex":"design_other","study_design_gemma":"not_applicable","domain_scores_codex":[0.99833655,0.00039401645,0.00046761168,0.00037553086,0.00017098106,0.0002552985],"domain_scores_gemma":[0.99938595,0.0002040075,0.0001609678,0.00015560495,0.00003791047,0.000055528566],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036424666,0.00030519295,0.0007279861,0.00020738166,0.00016428537,0.000037923925,0.00009669806,0.00021451025,0.00006279998],"category_scores_gemma":[0.0000042029446,0.00020310591,0.00009536482,0.00031489012,0.0001210682,0.000043300286,0.000008622033,0.0003700064,2.0322763e-7],"study_design_candidate":"design_other","study_design_consensus":null,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00013466357,0.000042731695,0.00004458022,0.0033590344,0.00016939711,6.928517e-7,0.00039228288,0.000001231733,0.00048175795,0.0010898064,0.000010583745,0.99427325],"study_design_scores_gemma":[0.0044171563,0.0011800582,0.00031294857,0.012284841,0.0010389654,0.00003778416,0.000631092,0.00009280609,0.0052545685,0.010471224,0.963218,0.0010605911],"about_ca_topic_score_codex":0.000094546005,"about_ca_topic_score_gemma":0.00003919837,"teacher_disagreement_score":0.99321264,"about_ca_system_score_codex":0.00003495022,"about_ca_system_score_gemma":0.00008565881,"threshold_uncertainty_score":0.8282419},"labels":[],"label_agreement":null},{"id":"W4411527616","doi":"10.1038/s41392-025-02286-9","title":"Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Traumatic Brain Injury Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"McGill University Health Centre","funders":"National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; National Institute on Minority Health and Health Disparities; Université de Lille; Infrastructures en Biologie Santé et Agronomie; American University of Beirut","keywords":"Traumatic brain injury; Neuroscience; Neuroprotection; Chronic traumatic encephalopathy; Hippocampus; Cognition; Medicine; Disease; Bioinformatics; Psychology; Poison control; Biology; Concussion; Injury prevention; Pathology; Psychiatry","score_opus":0.06296061287467083,"score_gpt":0.3360623387640256,"score_spread":0.2731017258893548,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4411527616","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9910043,0.0033532067,0.0006922472,0.0030780437,0.00011328802,0.0013776149,0.000029043122,0.00006670906,0.0002855733],"genre_scores_gemma":[0.9966507,0.0016836232,0.0007310983,0.0005296319,0.00007167995,0.00010193027,0.000016800657,0.000028145394,0.00018640902],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9982735,0.00029183144,0.00037969195,0.0005358856,0.00022756074,0.00029156267],"domain_scores_gemma":[0.99940467,0.00017463292,0.000058717087,0.00016539606,0.00007473046,0.000121883866],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00046601763,0.00025775842,0.00040821693,0.00046600844,0.00015552549,0.000079339756,0.00005346205,0.00016458712,0.00016388737],"category_scores_gemma":[0.000045703004,0.00022580891,0.000050059876,0.00048568466,0.000313822,0.00018445705,0.000014841601,0.0005708491,0.0000012597025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0031024578,0.0002511516,0.0025998123,0.00019653169,0.00012931626,0.000013998181,0.0034933125,0.000021316968,0.8959722,0.000694139,0.00018344502,0.093342304],"study_design_scores_gemma":[0.0101099545,0.004068372,0.2714759,0.00090940186,0.000053279913,0.000075080636,0.0026090192,0.0007041875,0.6973813,0.009018859,0.0029382347,0.00065639144],"about_ca_topic_score_codex":0.00006376689,"about_ca_topic_score_gemma":0.00001672533,"teacher_disagreement_score":0.26887608,"about_ca_system_score_codex":0.00006162054,"about_ca_system_score_gemma":0.000072643285,"threshold_uncertainty_score":0.92082196},"labels":[],"label_agreement":null},{"id":"W4411779720","doi":"10.1038/s41392-025-02292-x","title":"Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"Wnt signaling pathway; Cancer research; Pancreatic cancer; GSK-3; Biology; Carcinogenesis; Catenin; Cell biology; Signal transduction; Cancer; Genetics","score_opus":0.009636504886036424,"score_gpt":0.231127106957857,"score_spread":0.22149060207182056,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4411779720","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9848914,0.0044017206,0.008899083,0.0007653206,0.00034144646,0.00036731508,0.000021904958,0.00007152735,0.00024025109],"genre_scores_gemma":[0.9943881,0.0026799738,0.0005617779,0.0003610648,0.00022743412,0.00011161697,0.0007445411,0.000031488566,0.00089401676],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9986344,0.00011126313,0.000337163,0.0004872374,0.00016650415,0.00026343763],"domain_scores_gemma":[0.9994652,0.000022762693,0.00009444429,0.00014717273,0.00018543615,0.00008496206],"candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00016866806,0.0002918164,0.00023334092,0.0001410424,0.00023178745,0.000051305866,0.00011159154,0.00020232714,0.00026003132],"category_scores_gemma":[0.000013557403,0.00027117538,0.000094305615,0.00033917042,0.00013534923,0.000027974798,0.00001249285,0.00012601964,0.0000054518846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00046897528,0.00009568044,0.0042157574,0.000027091573,0.00019334619,0.0000022966453,0.00014871903,0.00015240077,0.9858749,0.00013319137,0.00015023057,0.008537449],"study_design_scores_gemma":[0.0014484951,0.00023434071,0.016050128,0.00003324631,0.000030944222,0.000007924212,0.00010595345,0.00015492535,0.97567385,0.00046598935,0.005476714,0.00031747873],"about_ca_topic_score_codex":0.00006311693,"about_ca_topic_score_gemma":0.000013891421,"teacher_disagreement_score":0.011834371,"about_ca_system_score_codex":0.000029739322,"about_ca_system_score_gemma":0.00017277131,"threshold_uncertainty_score":0.9999741},"labels":[],"label_agreement":null},{"id":"W4413361839","doi":"10.1038/s41392-026-02623-6","title":"Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Seoul National University Hospital; National Research Foundation of Korea; Korea Institute of Science and Technology; Seoul National University; National Research Foundation","keywords":"Immunotherapy; Medicine; Immunology; Computer science; Immune system","score_opus":0.01639848836613675,"score_gpt":0.23078879112232586,"score_spread":0.21439030275618912,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4413361839","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.78768045,0.14939187,0.047370967,0.0025354838,0.009153238,0.00212844,0.00008318167,0.00036413156,0.001292214],"genre_scores_gemma":[0.98354745,0.009563004,0.0002693451,0.000731444,0.00006624797,0.000079344914,0.00014190683,0.000028740145,0.005572513],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9987509,0.00017015498,0.0003343433,0.00040531406,0.000040886007,0.00029838955],"domain_scores_gemma":[0.9995228,0.000086827014,0.00008722255,0.00015700987,0.00011763655,0.000028522769],"candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00020008627,0.00025422784,0.00031084355,0.00022745335,0.00053801923,0.00005830694,0.00008609616,0.0002313774,0.0013701004],"category_scores_gemma":[0.000004342814,0.00023102718,0.00024585854,0.00014768231,0.0001792245,0.00015246334,0.000007770529,0.0002693917,0.000008647993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0028725397,0.00008883658,0.000048468864,0.000041410894,0.00072010094,4.195504e-7,0.000905559,0.000031667903,0.93775535,0.00027869426,0.0014124111,0.055844516],"study_design_scores_gemma":[0.0057640392,0.00088952674,0.00066711725,0.000075166245,0.000075682525,0.000020157864,0.0017174035,0.0001801588,0.5913056,0.000077452394,0.39894187,0.0002857893],"about_ca_topic_score_codex":0.00007715578,"about_ca_topic_score_gemma":0.0000044163703,"teacher_disagreement_score":0.39752945,"about_ca_system_score_codex":0.00003591427,"about_ca_system_score_gemma":0.000036524,"threshold_uncertainty_score":0.9995428},"labels":[],"label_agreement":null},{"id":"W4415679702","doi":"10.1038/s41392-025-02450-1","title":"Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Institute of Aging","funders":"National Key Research and Development Program of China; Key Research and Development Program of Ningxia; Natural Science Foundation of Henan Province; Zhengzhou University; Science and Technology Commission of Shanghai Municipality; First Affiliated Hospital of Zhengzhou University; National Natural Science Foundation of China; Ministry of Science and Technology of the People's Republic of China; National Science Foundation","keywords":"Reactive oxygen species; Rhodopsin; Mitochondrion; Retinal; Neurodegeneration; Retina; Endoplasmic reticulum; Oxidative stress","score_opus":0.0061311373789189475,"score_gpt":0.21910586750342836,"score_spread":0.2129747301245094,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4415679702","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9308284,0.0055416594,0.058414284,0.0029499305,0.0015335954,0.0004220764,0.0000110116,0.000032340053,0.000266735],"genre_scores_gemma":[0.99577725,0.0016997876,0.00042014616,0.00073962554,0.00021105623,0.00005320371,0.00014056417,0.000017146773,0.0009412437],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9988929,0.00020723704,0.00025119667,0.00036964015,0.00008427888,0.00019471585],"domain_scores_gemma":[0.99970984,0.000014735942,0.000042405554,0.00013995942,0.000048615173,0.000044417575],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016014502,0.00017887582,0.0001397068,0.00008309481,0.00012637899,0.00003299836,0.000098689605,0.00014717723,0.00012709918],"category_scores_gemma":[0.000012387827,0.00014324095,0.00006974875,0.00019784414,0.000050560004,0.000008093789,0.000010243379,0.00015702608,0.0000023899572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.00040654663,0.000058151174,0.00009383497,0.000006684023,0.00003175957,0.0000011570334,0.00013724294,0.00046551973,0.9952195,0.000118377066,0.0018460932,0.0016151288],"study_design_scores_gemma":[0.0010789055,0.00023113364,0.00032072506,0.000008955207,0.00000975687,0.000018138438,0.00005860362,0.00043536624,0.93617606,0.000109207445,0.06140293,0.00015020337],"about_ca_topic_score_codex":0.000021356362,"about_ca_topic_score_gemma":0.000024679843,"teacher_disagreement_score":0.06494886,"about_ca_system_score_codex":0.000009845314,"about_ca_system_score_gemma":0.00002621994,"threshold_uncertainty_score":0.5841196},"labels":[],"label_agreement":null},{"id":"W4416609113","doi":"10.1038/s41392-025-02467-6","title":"Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Neuroligin; Hippocampus; Cofilin; Dendritic spine; Signal transduction; Synapse; Extracellular; Autism","score_opus":0.0980784845183198,"score_gpt":0.3292302318265303,"score_spread":0.23115174730821048,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W4416609113","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.992566,0.000035561596,0.00010028533,0.0048391777,0.00079098943,0.000626739,0.000008078312,0.000099592544,0.0009336004],"genre_scores_gemma":[0.9977202,0.000112859256,0.000017070508,0.001232477,0.00021237129,0.00005343735,0.0000018172668,0.000016371183,0.0006333994],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.9985295,0.00026884268,0.00028307035,0.00046880185,0.0002223763,0.00022744079],"domain_scores_gemma":[0.99959815,0.000075551194,0.00012146738,0.00010546932,0.00006607051,0.000033285487],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015648577,0.00019688894,0.00024325534,0.00017987631,0.00039035326,0.000029194925,0.00012867285,0.00009129564,0.00013392181],"category_scores_gemma":[0.000053995172,0.00016972123,0.00008903344,0.0004664839,0.00013426949,0.00017952468,0.0000082886745,0.00032775648,0.0000061977416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0013646126,0.00015326252,0.000002076064,0.000049651466,0.000011635194,0.0000043876375,0.00078227924,0.0000075112894,0.978907,0.0048556323,0.00021172296,0.0136502115],"study_design_scores_gemma":[0.001048364,0.0003597405,0.00029002776,0.000027725502,0.000009016137,0.000009069372,0.00015287894,0.000055091718,0.99343145,0.0036364277,0.0008373364,0.00014285998],"about_ca_topic_score_codex":0.000003610345,"about_ca_topic_score_gemma":6.675263e-7,"teacher_disagreement_score":0.014524445,"about_ca_system_score_codex":0.000018587818,"about_ca_system_score_gemma":0.000051613737,"threshold_uncertainty_score":0.6921031},"labels":[],"label_agreement":null},{"id":"W7116727433","doi":"10.1038/s41392-025-02508-0","title":"Working together: a multi-component intranasal vaccine provides synergistic protection against COVID-19","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Health Sciences North; University of Sudbury; McMaster University; University of Guelph","funders":"","keywords":"Nasal administration; Immunity; Immune system; Antibody; MEDLINE; Vaccination","score_opus":0.055886751056519406,"score_gpt":0.33182500041176927,"score_spread":0.27593824935524985,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7116727433","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.8639289,0.006210122,0.12068395,0.005627694,0.00051951705,0.0022748269,0.0000057740904,0.0004087844,0.0003403888],"genre_scores_gemma":[0.9773911,0.00039209405,0.00041429026,0.021168439,0.00024030951,0.0002471655,0.000013360412,0.000034164277,0.000099069366],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99818665,0.00019421073,0.0003842867,0.0005364547,0.00031924632,0.00037915717],"domain_scores_gemma":[0.9993944,0.000082600665,0.00006636877,0.00022062878,0.00011819443,0.00011781981],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004518737,0.0002818108,0.0003742917,0.0004705156,0.00033969415,0.000052763964,0.000102247475,0.00018513421,0.00007714924],"category_scores_gemma":[0.00006165459,0.00023461218,0.00015205356,0.0006936048,0.00011939438,0.0000978851,0.000010876236,0.0004880616,0.0000063873476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.0042422735,0.0004982798,0.0037805296,0.0002473613,0.00032488693,0.00003781339,0.00086320133,0.00004727607,0.9050378,0.00017055156,0.00012256474,0.08462746],"study_design_scores_gemma":[0.016496306,0.0009458198,0.002619845,0.00031462987,0.000109001885,0.000055264583,0.00075085746,0.010278788,0.6487018,0.001022703,0.31820327,0.00050173665],"about_ca_topic_score_codex":0.00028321915,"about_ca_topic_score_gemma":0.000088116016,"teacher_disagreement_score":0.3180807,"about_ca_system_score_codex":0.00019541247,"about_ca_system_score_gemma":0.00037278212,"threshold_uncertainty_score":0.9567207},"labels":[],"label_agreement":null},{"id":"W7116731164","doi":"10.1038/s41392-025-02507-1","title":"YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"route_ca_aff":true,"route_ca_fund":false,"route_ca_venue":false,"route_about_ca":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Chinese University of Hong Kong; Research Grants Council, University Grants Committee; National Natural Science Foundation of China","keywords":"Oxaliplatin; Colorectal cancer; Carcinogenesis; Gene knockdown; LGR5; Cancer stem cell; Apoptosis; Chemotherapy; Stem cell","score_opus":0.010156306447604258,"score_gpt":0.2719783547974114,"score_spread":0.26182204834980716,"validation_status":"score_only:v0-immature-baseline","prediction":{"id":"W7116731164","genre_codex":"empirical","genre_gemma":"empirical","domain_codex":null,"domain_gemma":null,"model_version":"codex-gemma-dda1882f352a","genre_candidate":"empirical","genre_consensus":"empirical","domain_candidate":null,"domain_consensus":null,"prediction_status":"machine_predicted_unvalidated","genre_scores_codex":[0.9819659,0.01120916,0.0014103943,0.00470136,0.00023786881,0.00033392856,0.000030013724,0.000015405507,0.00009596929],"genre_scores_gemma":[0.99498343,0.0033532216,0.00003259937,0.00075614196,0.0000754084,0.00016659845,0.00003589254,0.000017458053,0.00057921774],"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","domain_scores_codex":[0.99898386,0.0002075963,0.00019113693,0.00032564782,0.0000936819,0.00019808233],"domain_scores_gemma":[0.9996916,0.000022296375,0.000047378024,0.00014485032,0.000057291814,0.000036580932],"candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027943577,0.00015893957,0.00013498907,0.00006196939,0.00018919985,0.000044027405,0.00012689036,0.00013704166,0.00015615672],"category_scores_gemma":[0.000005015883,0.0001205177,0.000060735252,0.000226844,0.00009735396,0.000010059912,0.0000069402054,0.00013650404,5.677232e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_system_candidate":false,"about_ca_system_consensus":false,"study_design_scores_codex":[0.002392832,0.00007550617,0.0007162025,0.0000051423353,0.00006536066,3.5671624e-7,0.00033098864,0.000066511,0.9710831,0.000022542843,0.0009645655,0.024276877],"study_design_scores_gemma":[0.0016417528,0.0001242373,0.012415373,0.000016071228,0.000005995891,0.0000021111143,0.00023568972,0.00013393973,0.9289299,0.0000799023,0.05626626,0.00014874646],"about_ca_topic_score_codex":0.000074998294,"about_ca_topic_score_gemma":0.000043489144,"teacher_disagreement_score":0.055301692,"about_ca_system_score_codex":0.000025177222,"about_ca_system_score_gemma":0.00011322893,"threshold_uncertainty_score":0.49145693},"labels":[],"label_agreement":null}]}