{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":219,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":219,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"7f074b77c00f","filters":{"topic":"Alkaloids: synthesis and pharmacology"}},"results":[{"id":"W2057745527","doi":"10.1073/pnas.1501821112","title":"Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":241,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vindoline; Catharanthus roseus; Biochemistry; Biology; Vinblastine; Biosynthesis; Enzyme; Genetics","authors":[{"name":"Yang Qu","is_ca":false},{"name":"Michael L. A. E. Easson","is_ca":false},{"name":"Jordan Froese","is_ca":true},{"name":"Razvan Simionescu","is_ca":true},{"name":"Tomáš Hudlický","is_ca":true},{"name":"Vincenzo De Luca","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.160954190080054,"gpt":0.4177878582878835,"spread":0.2568336682078295,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002956737,0.0001091977,0.0002142434,0.00008488925,0.0001657144,0.000009036943,0.0008315524,0.0001089857,0.00005271364],"category_scores_gemma":[0.00067073,0.00005828048,0.00005218202,0.0005930212,0.0006272846,0.0001632992,0.0002431064,0.00036028,0.000002976217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004023816,"about_ca_system_score_gemma":0.00007894933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003937124,"about_ca_topic_score_gemma":0.00000493394,"domain_scores_codex":[0.9985525,0.00009816471,0.0003561356,0.0002184167,0.0005940019,0.0001807967],"domain_scores_gemma":[0.9987292,0.0005045173,0.000416001,0.00001263558,0.0002725225,0.00006507761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003972122,0.0003061173,0.06930703,0.00007342394,0.00009833447,3.165299e-8,0.004814477,0.001374512,0.8850484,0.01933526,0.01683593,0.002409271],"study_design_scores_gemma":[0.0009811964,0.0000733566,0.2348748,0.0001030312,0.00006900857,0.00000615214,0.0006661487,0.01499319,0.7244347,0.005501305,0.01815492,0.0001421226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758962,0.000599325,6.525912e-7,0.0210974,0.0001485134,0.0004106562,0.00009836045,0.000004769873,0.001744167],"genre_scores_gemma":[0.9974781,0.00006080167,0.0001380018,0.001957771,0.0001596368,0.00002364032,2.351987e-7,0.000004538177,0.0001772384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1655678,"threshold_uncertainty_score":0.2376609,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2173132441","doi":"10.1155/2015/968786","title":"Following “the Roots” of Kratom (<i>Mitragyna speciosa</i>): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries","year":2015,"lang":"en","type":"review","venue":"BioMed Research International","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":232,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"European Commission; Public Health Agency; Public Health Agency of Canada; World Health Organization","keywords":"Psychoactive drug; Productivity; Southeast asia; Recreation; Consumption (sociology); Traditional medicine; Drug; Medicine; Pharmacology; Biology; Sociology; Economic growth; Economics; Social science; Ethnology; Ecology","authors":[{"name":"Eduardo Cinosi","is_ca":false},{"name":"Giovanni Martinotti","is_ca":false},{"name":"Pierluigi Simonato","is_ca":false},{"name":"Darshan Singh","is_ca":false},{"name":"Zsolt Demetrovics","is_ca":false},{"name":"Andrés Román-Urrestarazu","is_ca":false},{"name":"Francesco Saverio Bersani","is_ca":false},{"name":"Balasingam Vicknasingam","is_ca":false},{"name":"Giulia Piazzon","is_ca":false},{"name":"Jih‐Heng Li","is_ca":false},{"name":"Wen-Jing Yu","is_ca":false},{"name":"Máté Kapitány‐Fövény","is_ca":false},{"name":"Judit Farkas","is_ca":false},{"name":"Massimo di Giannantonio","is_ca":false},{"name":"Ornella Corazza","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3133932340761449,"gpt":0.5213274845619251,"spread":0.2079342504857802,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006381839,0.0003322108,0.0008528322,0.00105707,0.0001499331,0.00005957399,0.0008993599,0.0003304823,0.0005854441],"category_scores_gemma":[0.0007425545,0.0002334778,0.0001834705,0.001236177,0.0005975756,0.0002886482,0.0002551017,0.001346165,0.0000440694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009958013,"about_ca_system_score_gemma":0.00104556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001483537,"about_ca_topic_score_gemma":0.001560723,"domain_scores_codex":[0.99286,0.004037426,0.0008926945,0.0006840014,0.001058594,0.0004673461],"domain_scores_gemma":[0.9946765,0.003890028,0.0003241493,0.0003177088,0.0005019372,0.0002896262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02645384,0.01171252,0.07679985,0.002263953,0.008878475,0.0003516324,0.02477711,0.0003833168,0.003838159,0.02341208,0.05052146,0.7706076],"study_design_scores_gemma":[0.001557131,0.0002045433,0.06463756,0.001898098,0.0002749872,0.00002148926,0.00119184,0.0000640141,0.0002126938,0.001331076,0.928177,0.000429598],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6645543,0.3178404,0.0000594251,0.004382525,0.002920767,0.004326182,0.005285364,0.0000173056,0.0006137788],"genre_scores_gemma":[0.8664725,0.1246576,0.0003798205,0.0001497409,0.002784778,0.003048302,0.0008858074,0.0001003397,0.001521089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8776555,"threshold_uncertainty_score":0.9520948,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1977564671","doi":"10.1038/nature13273","title":"Total synthesis and isolation of citrinalin and cyclopiamine congeners","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":182,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of General Medical Sciences; U.S. Public Health Service","keywords":"Nitrogen; Chemistry; Molecule; Bicyclic molecule; Chemical synthesis; Carbon fibers; Nitrogen atom; Stereochemistry; Combinatorial chemistry; Organic chemistry; In vitro; Ring (chemistry); Biochemistry; Materials science","authors":[{"name":"Eduardo V. Mercado-Marin","is_ca":false},{"name":"Pablo García‐Reynaga","is_ca":false},{"name":"Stelamar Romminger","is_ca":false},{"name":"Eli F. Pimenta","is_ca":false},{"name":"David K. Romney","is_ca":false},{"name":"Michael W. Lodewyk","is_ca":false},{"name":"David E. Williams","is_ca":true},{"name":"Raymond J. Andersen","is_ca":true},{"name":"Scott J. Miller","is_ca":false},{"name":"Dean J. Tantillo","is_ca":false},{"name":"Roberto G. S. Berlinck","is_ca":false},{"name":"Richmond Sarpong","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03348277036770628,"gpt":0.3777991302943421,"spread":0.3443163599266358,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005992593,0.0001620861,0.0002972585,0.00009535711,0.0001111325,0.000008155917,0.00009065677,0.001323646,0.0004848048],"category_scores_gemma":[0.0002578176,0.0001456103,0.00004441524,0.000102137,0.0002245887,0.00006474087,0.00005909249,0.001253551,0.00000689048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001349416,"about_ca_system_score_gemma":0.00001845492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009769562,"about_ca_topic_score_gemma":0.000007346983,"domain_scores_codex":[0.9988719,0.0003469736,0.0002257309,0.0002504869,0.00009193971,0.000212957],"domain_scores_gemma":[0.9985462,0.001026996,0.0001272199,0.00009933551,0.00006907317,0.000131209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001117765,0.0002828546,0.08845639,0.0003054051,0.0005450154,0.00001324145,0.0007206374,0.0001072993,0.7091167,0.0173506,0.009155884,0.1728282],"study_design_scores_gemma":[0.003802413,0.0004881865,0.1809728,0.00005642399,0.0010456,0.0001932865,0.0001906463,0.01801047,0.4844207,0.002143391,0.307822,0.0008540956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911699,0.003101559,0.00009611835,0.001372445,0.0005080977,0.0001623329,0.00003670844,0.00002997636,0.003522871],"genre_scores_gemma":[0.9969749,0.0005828844,0.0004293018,0.001385329,0.000241115,0.00001627711,0.000007052342,0.0000146509,0.0003484275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2986661,"threshold_uncertainty_score":0.9999728,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2789706157","doi":"10.1073/pnas.1719979115","title":"Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19 <i>E</i> -geissoschizine","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":162,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"","keywords":"Aspidosperma; Indole test; Biosynthesis; Chemistry; Gene silencing; Acetylation; Stereochemistry; In vitro; In vivo; Biochemistry; Enzyme; Gene; Biology; Genetics","authors":[{"name":"Yang Qu","is_ca":true},{"name":"Michael L. A. E. Easson","is_ca":true},{"name":"Razvan Simionescu","is_ca":true},{"name":"Josef Hájíček","is_ca":true},{"name":"Antje M. K. Thamm","is_ca":true},{"name":"Vonny Salim","is_ca":true},{"name":"Vincenzo De Luca","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1235776810297281,"gpt":0.4133817160752224,"spread":0.2898040350454943,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002082944,0.0001629826,0.0003385203,0.0001078585,0.0004066546,0.0000083002,0.0009641496,0.0002812241,0.00007593883],"category_scores_gemma":[0.0007603301,0.00010406,0.0001374809,0.0004099949,0.002874434,0.000232683,0.0002621454,0.0003054324,0.000001027589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003200558,"about_ca_system_score_gemma":0.00009013312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005505447,"about_ca_topic_score_gemma":0.00000185158,"domain_scores_codex":[0.9982471,0.00006391762,0.0006160275,0.0003107158,0.000519441,0.0002428257],"domain_scores_gemma":[0.9973719,0.001000828,0.001068784,0.0000216613,0.0004698913,0.00006696876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002755046,0.0001646638,0.01639611,0.00008978324,0.00008144169,5.13756e-9,0.0004122505,0.00002168799,0.9697163,0.007200478,0.002401299,0.003240515],"study_design_scores_gemma":[0.0009250377,0.0001915317,0.04770479,0.00006333909,0.00009676136,0.000003917672,0.0001350823,0.00450666,0.9337664,0.008248911,0.004252249,0.0001052826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937439,0.000549247,0.00001041057,0.003012677,0.0002308641,0.000537436,0.0004330821,0.000009082574,0.001473278],"genre_scores_gemma":[0.9976206,0.0001168566,0.0009131241,0.0009746744,0.0002290571,0.00001988629,8.496385e-7,0.000008313823,0.0001166213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03594983,"threshold_uncertainty_score":0.9998392,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2772290079","doi":"10.1016/j.drugalcdep.2017.10.012","title":"Kratom use and mental health: A systematic review","year":2017,"lang":"en","type":"review","venue":"Drug and Alcohol Dependence","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":149,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Mental health; Systematic review; Psychology; MEDLINE; Psychiatry; Biology","authors":[{"name":"Marc T. Swogger","is_ca":false},{"name":"Zach Walsh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3679910781308376,"gpt":0.5306122619574599,"spread":0.1626211838266223,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002939147,0.0008453654,0.004289609,0.0001680327,0.001054401,0.0001933457,0.0007372778,0.0005653448,0.0004288083],"category_scores_gemma":[0.0003430533,0.0006479059,0.000410876,0.0001240734,0.0004377563,0.0003512207,0.0004217878,0.00156191,0.0003001973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001063511,"about_ca_system_score_gemma":0.0003542793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007381435,"about_ca_topic_score_gemma":0.00003697437,"domain_scores_codex":[0.9939039,0.002740492,0.001380946,0.0009532864,0.0002763957,0.000745019],"domain_scores_gemma":[0.9956951,0.001399254,0.001528963,0.0006575305,0.00007614744,0.000643072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001168235,0.00009176338,0.00004804977,0.8297318,0.000729759,0.00009641458,0.0001676481,3.485158e-8,0.000002232737,0.0001711121,0.02295166,0.1459979],"study_design_scores_gemma":[0.0003309128,0.00003447699,0.000004833068,0.2006235,0.002751063,0.0007857329,0.00001562881,0.00001220909,0.000002574633,0.00001545667,0.7949029,0.0005206516],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003138426,0.9932135,0.000002243966,0.000701203,0.001009761,0.004181255,0.0004850395,0.00007579762,0.0002997837],"genre_scores_gemma":[0.0001619518,0.9917483,0.00003778673,0.003965484,0.0001820106,0.0005869506,0.0001091728,0.00007123788,0.003137063],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7719513,"threshold_uncertainty_score":0.9995972,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2594965426","doi":"10.1016/j.jep.2017.03.020","title":"A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna korth: Implications for products sold as kratom","year":2017,"lang":"en","type":"review","venue":"Journal of Ethnopharmacology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":149,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"British Columbia Institute of Technology; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Traditional medicine; Phytochemical; Genus; Bark (sound); Medicine; Biology; Botany; Ecology","authors":[{"name":"Paula N. Brown","is_ca":true},{"name":"Jensen A. Lund","is_ca":true},{"name":"Susan J. Murch","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3904282359774131,"gpt":0.5695507437010757,"spread":0.1791225077236627,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.004174768,0.0008182047,0.004174405,0.0002708627,0.0005757166,0.00002295721,0.002251884,0.001478009,0.001012979],"category_scores_gemma":[0.002361309,0.0005502243,0.001561891,0.0003953027,0.001739316,0.0001498487,0.000447696,0.003950104,0.00002654569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084796,"about_ca_system_score_gemma":0.002464058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005437637,"about_ca_topic_score_gemma":0.000001910121,"domain_scores_codex":[0.9931818,0.00192178,0.0030181,0.0007077722,0.0003252727,0.0008452376],"domain_scores_gemma":[0.9873888,0.003993899,0.006186062,0.0007606953,0.001141256,0.0005292661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003264607,0.0006902827,0.00003975127,0.05096352,0.003360058,0.00005826046,0.0001157182,5.256944e-7,0.006533704,0.0004145672,0.1441034,0.7933937],"study_design_scores_gemma":[0.001592298,0.0004849796,0.00005759899,0.00947028,0.01445931,0.001052017,0.0000136681,0.00000369213,0.000856636,0.0001862371,0.9713758,0.0004474631],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00142809,0.9802288,0.00001240112,0.007678841,0.006510494,0.003199855,0.0002896002,0.00001821776,0.0006337335],"genre_scores_gemma":[0.0006590726,0.9907929,0.0001950417,0.004722927,0.002388742,0.0005030196,0.00002050922,0.0001009633,0.0006168113],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8272724,"threshold_uncertainty_score":0.9999002,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1964900033","doi":"10.1021/ol800259s","title":"Total Synthesis of (±)-Mersicarpine","year":2008,"lang":"en","type":"article","venue":"Organic Letters","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":145,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Total synthesis; Moiety; Natural product; Stereochemistry; Radical cyclization; Indole test; Alkaloid; Crystal structure; Organic chemistry","authors":[{"name":"Jakob Magolan","is_ca":true},{"name":"Cheryl A. Carson","is_ca":true},{"name":"Michael A. Kerr","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06259534023347077,"gpt":0.3475455861699195,"spread":0.2849502459364487,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003574511,0.0002463847,0.0004396138,0.0001300026,0.0002355855,0.000003705622,0.0003411758,0.0002432414,0.01235194],"category_scores_gemma":[0.0001382016,0.0002370862,0.0001811694,0.0002751081,0.0005099078,0.000100283,0.00009291845,0.0004941365,0.0005650113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007563571,"about_ca_system_score_gemma":0.00008102097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002298443,"about_ca_topic_score_gemma":0.000002230593,"domain_scores_codex":[0.9982175,0.000368374,0.0004226004,0.0003293089,0.0001793049,0.0004828891],"domain_scores_gemma":[0.9985865,0.0007144002,0.0001955757,0.0002522003,0.00005272015,0.000198644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001438386,0.0002186587,0.006280344,0.00002795282,0.0003016003,0.0001080113,0.0004660962,0.00004323946,0.9460074,0.000125864,0.04362289,0.002654078],"study_design_scores_gemma":[0.0008811763,0.00006947195,0.009581683,0.000008548053,0.0002496082,0.0002816114,0.00005466155,0.0001231125,0.965541,0.00001508532,0.02287992,0.0003141077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902497,0.0002713039,0.0001263562,0.005599555,0.001028669,0.0001954007,0.00003513681,0.0000869131,0.002406951],"genre_scores_gemma":[0.9929127,0.0002771835,0.0001849715,0.005877631,0.0003767189,0.00002713506,0.000006585404,0.00004242242,0.0002946133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02074297,"threshold_uncertainty_score":0.9885509,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2176160743","doi":"10.1080/02791072.2015.1096434","title":"Experiences of Kratom Users: A Qualitative Analysis","year":2015,"lang":"en","type":"article","venue":"Journal of Psychoactive Drugs","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":143,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; Kelowna General Hospital; University of British Columbia","funders":"National Institute on Drug Abuse","keywords":"Anxiety; Psychoactive substance; Traditional medicine; Psychology; Mood; Qualitative analysis; Medicine; Qualitative research; Psychiatry; Sociology; Social science","authors":[{"name":"Marc T. Swogger","is_ca":false},{"name":"Elaine Hart","is_ca":false},{"name":"Fire Erowid","is_ca":false},{"name":"Earth Erowid","is_ca":false},{"name":"Nicole Trabold","is_ca":false},{"name":"Kaila Yee","is_ca":false},{"name":"Kimberly A. Parkhurst","is_ca":false},{"name":"Brittany M. Priddy","is_ca":false},{"name":"Zach Walsh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2049352440053097,"gpt":0.5405466248942608,"spread":0.335611380888951,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003287004,0.0002297649,0.0008117561,0.000608371,0.00008407386,0.00001445968,0.0004645189,0.0002439353,0.002205694],"category_scores_gemma":[0.0002469781,0.0001847041,0.0005050009,0.0009932404,0.0004407034,0.0003524025,0.00003868308,0.0007216131,0.00004248199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001176504,"about_ca_system_score_gemma":0.0002626897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002169657,"about_ca_topic_score_gemma":0.000005039116,"domain_scores_codex":[0.996115,0.001960052,0.0009431351,0.0002219976,0.0004379145,0.0003218456],"domain_scores_gemma":[0.995818,0.001239583,0.001412232,0.0001571983,0.0009297152,0.0004433267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"qualitative","study_design_scores_codex":[0.004970116,0.001547942,0.00620764,0.00002611565,0.01062999,0.00005159917,0.917705,0.0006634183,0.01786303,0.0007034881,0.03538863,0.004243005],"study_design_scores_gemma":[0.005089477,0.001386306,0.002080078,0.00002842259,0.00415067,0.00005533403,0.8268815,0.0004917258,0.09646653,0.002879719,0.06000905,0.0004811753],"study_design_candidate":"qualitative","study_design_consensus":"qualitative","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986824,0.001259014,0.001038316,0.0005433476,0.001846587,0.0001417495,0.0000274477,0.00001069446,0.008308803],"genre_scores_gemma":[0.9977453,0.0001572609,0.0007189733,0.0006772176,0.0003608858,0.0000170833,0.000002515986,0.00001527397,0.0003055027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09082351,"threshold_uncertainty_score":0.9987064,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1534015176","doi":"10.1111/adb.12185","title":"Abuse potential and adverse cognitive effects of mitragynine (kratom)","year":2014,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":137,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Universiti Sains Malaysia","keywords":"Conditioned place preference; Pharmacology; Addiction; Medicine; Dopamine; Analgesic; Stimulant; Morphine; Anesthesia; Psychology; Psychiatry; Internal medicine","authors":[{"name":"Nurul H.M. Yusoff","is_ca":false},{"name":"Farah Wahida Suhaimi","is_ca":false},{"name":"Raja Vadivelu","is_ca":false},{"name":"Zurina Hassan","is_ca":false},{"name":"Anne Rümler","is_ca":false},{"name":"Andrea Rotter","is_ca":false},{"name":"Davide Amato","is_ca":false},{"name":"Hans C. Dringenberg","is_ca":true},{"name":"Sharif Mahsufi Mansor","is_ca":false},{"name":"Visweswaran Navaratnam","is_ca":false},{"name":"Christian P. Müller","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02564051546223433,"gpt":0.3671828697192633,"spread":0.341542354257029,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004807319,0.0002222226,0.0004050875,0.0001575636,0.000172816,0.00000305618,0.0001218418,0.0005154341,0.002407933],"category_scores_gemma":[0.000189733,0.0002037598,0.0001023499,0.0001366063,0.0006033802,0.00007049597,0.00005278665,0.0004593,0.0001373408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001828886,"about_ca_system_score_gemma":0.0000275162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002464211,"about_ca_topic_score_gemma":0.000008353952,"domain_scores_codex":[0.997812,0.001040325,0.0003598353,0.0003641595,0.00005882012,0.0003649156],"domain_scores_gemma":[0.9979594,0.001405841,0.0002238545,0.0001099292,0.0001196154,0.0001814024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00194274,0.0007920713,0.03636438,0.0001605516,0.001399607,0.00003703373,0.000998338,0.00005808279,0.8361051,0.005603897,0.005949464,0.1105887],"study_design_scores_gemma":[0.01352609,0.002898864,0.08831492,0.00007231223,0.002073854,0.0001989593,0.000200775,0.005266083,0.5422635,0.002099941,0.3422193,0.0008654066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911214,0.001130606,0.001699682,0.000158185,0.002078314,0.0003684534,0.00007115951,0.00008500026,0.003287191],"genre_scores_gemma":[0.996218,0.001109012,0.0000883001,0.001773933,0.0003886186,0.00006107838,0.00006736938,0.00001963608,0.0002739964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3362699,"threshold_uncertainty_score":0.998504,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2154484277","doi":"10.1111/j.1365-313x.2005.02557.x","title":"Localization of tabersonine 16‐hydroxylase and 16‐OH tabersonine‐16‐<i>O</i>‐methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in <i>Catharanthus roseus</i>","year":2005,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":133,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"","keywords":"Vindoline; Catharanthus roseus; Biosynthesis; Biochemistry; Indole alkaloid; Biology; Enzyme; Vinblastine; Indole test","authors":[{"name":"Jun Murata","is_ca":true},{"name":"Vincenzo De Luca","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05328759543132963,"gpt":0.3289899042008732,"spread":0.2757023087695436,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004115026,0.0004358753,0.0007801566,0.0003422389,0.0002926391,0.00003358355,0.0006099894,0.0003159383,0.001388312],"category_scores_gemma":[0.0002351655,0.0002832795,0.0001918266,0.0005790163,0.0003734717,0.0001914558,0.00008178206,0.001203061,0.00005314085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120449,"about_ca_system_score_gemma":0.0001617586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000420326,"about_ca_topic_score_gemma":0.001231092,"domain_scores_codex":[0.995234,0.002135342,0.001194338,0.0003589835,0.000358607,0.0007187297],"domain_scores_gemma":[0.9960223,0.002897751,0.0004728025,0.0002615425,0.000102703,0.0002428924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009650739,0.002868331,0.01941025,0.0002785688,0.0005501089,0.000260852,0.02222883,0.01332482,0.8930218,0.0007326323,0.01009901,0.02757412],"study_design_scores_gemma":[0.004235318,0.0003816836,0.0007788021,0.0001760614,0.000380227,0.001158103,0.0008405411,0.003290549,0.9520934,0.0003110422,0.03594223,0.0004120917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887571,0.002492589,0.0005963075,0.005378748,0.0003690258,0.0008100751,0.0007781159,0.00001739378,0.000800673],"genre_scores_gemma":[0.9919639,0.002392275,0.0001608955,0.004819375,0.0003829187,0.00004602268,0.00003036356,0.0000400415,0.0001641605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05907161,"threshold_uncertainty_score":0.9999619,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2034555473","doi":"10.1016/j.pbi.2014.03.006","title":"Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation","year":2014,"lang":"en","type":"review","venue":"Current Opinion in Plant Biology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":131,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Iridoid; Scrophulariaceae; Apocynaceae; Caprifoliaceae; Botany; Glycoside","authors":[{"name":"Vincenzo De Luca","is_ca":true},{"name":"Vonny Salim","is_ca":true},{"name":"Antje M. K. Thamm","is_ca":true},{"name":"Sayaka Masada","is_ca":true},{"name":"Yu Fang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3353411572519012,"gpt":0.5250614168337606,"spread":0.1897202595818594,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00193954,0.001137365,0.002753003,0.0009648802,0.0003003645,0.00005485261,0.0008025197,0.002042064,0.0005455508],"category_scores_gemma":[0.0001667342,0.000954797,0.0003782029,0.0003940952,0.0005875392,0.0001048654,0.0003722947,0.003007543,0.0004113989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602521,"about_ca_system_score_gemma":0.0003016401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006640424,"about_ca_topic_score_gemma":0.0000060391,"domain_scores_codex":[0.9919571,0.003539827,0.001698364,0.001474649,0.0001792422,0.001150763],"domain_scores_gemma":[0.99589,0.002178951,0.001129003,0.0004403272,0.00006680201,0.0002948712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002408214,0.0004483382,0.0006219943,0.008243322,0.0002141231,0.00000848094,0.0001309733,0.000006651371,0.00002161417,0.003172528,0.00714933,0.9797418],"study_design_scores_gemma":[0.001219438,0.0004374871,0.00006632854,0.005199566,0.0002412765,0.0001226378,0.00001125408,0.0003079689,0.00003736238,0.0002645604,0.9911356,0.0009565025],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004551741,0.9756548,0.00006833999,0.0001468267,0.01976914,0.001963206,0.001208025,0.0001380795,0.0005964533],"genre_scores_gemma":[0.002793058,0.9899839,0.00004285137,0.0002757788,0.002701968,0.0009289862,0.0031294,0.0001002109,0.00004382533],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9839863,"threshold_uncertainty_score":0.9992926,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2057108455","doi":"10.1016/s0021-9673(02)00204-2","title":"Screening of Catharanthus roseus secondary metabolites by high-performance liquid chromatography","year":2002,"lang":"en","type":"article","venue":"Journal of Chromatography A","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":126,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"Catharanthus roseus; Vindoline; Tryptamine; Chemistry; Chromatography; High-performance liquid chromatography; Indole alkaloid; Alkaloid; Metabolite; Indole test; Secondary metabolite; Vinblastine; Biochemistry; Stereochemistry; Biology","authors":[{"name":"Cyril Tikhomiroff","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04620708745433353,"gpt":0.3299708580066706,"spread":0.2837637705523371,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001408395,0.0005054063,0.001244197,0.001010999,0.0003168902,0.00003115866,0.0008474719,0.0005109353,0.005820435],"category_scores_gemma":[0.00005282809,0.0004455841,0.0008373233,0.001143255,0.0007210804,0.0005828331,0.00008579091,0.001454641,0.00002808104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002389008,"about_ca_system_score_gemma":0.00007462874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002189505,"about_ca_topic_score_gemma":0.000001662764,"domain_scores_codex":[0.9959471,0.000663639,0.001756793,0.0003435915,0.0005201636,0.0007687584],"domain_scores_gemma":[0.9965417,0.0006202439,0.001718164,0.0003057118,0.0003420912,0.0004720984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001819166,0.00198707,0.02932287,0.0004346538,0.00381229,0.0001522481,0.001393469,0.0001937723,0.8600214,0.0003227076,0.07194572,0.02859461],"study_design_scores_gemma":[0.005277112,0.001972048,0.01462141,0.0001600307,0.001183101,0.0007467669,0.0001539279,0.0006277817,0.8033084,0.0000963224,0.1711801,0.0006730314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551467,0.04016786,0.0001767755,0.0003601373,0.001360538,0.0002636258,0.0002019485,0.0000603279,0.002262031],"genre_scores_gemma":[0.9868001,0.01058226,0.000998175,0.001008423,0.0004478961,0.0000187817,0.00001180756,0.00006094632,0.00007158829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09923434,"threshold_uncertainty_score":0.9997996,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2326475802","doi":"10.1021/jo101209y","title":"Total Synthesis of (+)-Isatisine A","year":2010,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":120,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Tetrahydrofuran; Total synthesis; Dihydroxylation; Ring (chemistry); Stereochemistry; Decarboxylation; Enantiomer; Electrophilic aromatic substitution; Enantioselective synthesis; Medicinal chemistry; Organic chemistry; Catalysis","authors":[{"name":"Avedis Karadeolian","is_ca":true},{"name":"Michael A. Kerr","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03721998334317708,"gpt":0.3657909179936116,"spread":0.3285709346504345,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001755824,0.0001799366,0.0004008881,0.00003525278,0.0001250066,0.000006624933,0.0006201431,0.0003130453,0.03050253],"category_scores_gemma":[0.0006462404,0.0001226149,0.00016625,0.0001673362,0.0003815639,0.00006612107,0.00009339772,0.001536215,0.00003674255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003105694,"about_ca_system_score_gemma":0.000209777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004978867,"about_ca_topic_score_gemma":0.00000361476,"domain_scores_codex":[0.9985601,0.0002134913,0.0006523035,0.0001001455,0.0002096476,0.000264348],"domain_scores_gemma":[0.9970444,0.001602093,0.0007221476,0.0002377954,0.0002157633,0.0001778045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003799898,0.000229729,0.001499783,0.00005467612,0.0003047653,0.00001983123,0.0003174842,0.00001491974,0.9875804,0.00002062267,0.004183795,0.005393965],"study_design_scores_gemma":[0.0006667644,0.00004860412,0.002026968,0.00001491355,0.0005376713,0.001483518,0.0001684193,0.00004587762,0.9841609,0.0001643422,0.01055638,0.0001256384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930617,0.0004732518,0.00004648578,0.00155208,0.0009219755,0.00007031479,0.00001792575,0.00001211009,0.003844216],"genre_scores_gemma":[0.9979188,0.0002781902,0.0001589566,0.0002455075,0.0008279604,0.000001942757,7.317502e-7,0.0000245776,0.0005433084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03046579,"threshold_uncertainty_score":0.9703837,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3015612295","doi":"10.1111/add.15082","title":"Prevalence and description of kratom ( <i>Mitragyna speciosa</i> ) use in the United States: a cross‐sectional study","year":2020,"lang":"en","type":"article","venue":"Addiction","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":115,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"","funders":"","keywords":"Medicine; Cross-sectional study; Medical prescription; Confidence interval; Population; Quarter (Canadian coin); Young adult; Demography; Environmental health; Gerontology; Internal medicine; Geography","authors":[{"name":"Jonathan Schimmel","is_ca":false},{"name":"Elise Amioka","is_ca":false},{"name":"Karilynn Rockhill","is_ca":false},{"name":"Colleen M. Haynes","is_ca":false},{"name":"Joshua C. Black","is_ca":false},{"name":"Richard C. Dart","is_ca":false},{"name":"Janetta Iwanicki","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1726184134457086,"gpt":0.4007436880135186,"spread":0.2281252745678101,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008468991,0.0001573635,0.0001681038,0.0001150236,0.0001760898,0.0000413895,0.0001699432,0.0001691304,0.001063478],"category_scores_gemma":[0.00009620459,0.0001297035,0.0000493063,0.0004261348,0.0002010462,0.0002729817,0.00004496543,0.0005958269,0.00003088817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003929861,"about_ca_system_score_gemma":0.00002826209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002500475,"about_ca_topic_score_gemma":0.0000587293,"domain_scores_codex":[0.9977991,0.001056827,0.0004307645,0.0003082375,0.000183017,0.0002220776],"domain_scores_gemma":[0.9988524,0.0006838071,0.0001623315,0.0001102117,0.00009447072,0.00009679089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008255813,0.00061886,0.9830416,0.00003526085,0.0001353115,0.00002268439,0.005758443,0.001142691,0.005113721,0.000146226,0.002679144,0.0004804904],"study_design_scores_gemma":[0.00158313,0.0005295415,0.9786256,0.00000617668,0.0001605071,0.00001960336,0.0008160188,0.004982088,0.0009313804,0.00005484207,0.0121641,0.0001269951],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977638,0.0003029173,0.0001255788,0.0003049621,0.0004738123,0.0006790902,0.0001100027,0.00004187086,0.0001980396],"genre_scores_gemma":[0.9963992,0.0005003953,0.00001843419,0.002663484,0.000188037,0.00007954523,0.00004898068,0.0000127257,0.0000892017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009484953,"threshold_uncertainty_score":0.9998497,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2117476173","doi":"10.1104/pp.125.1.189","title":"Molecular and Biochemical Analysis of a Madagascar Periwinkle Root-Specific Minovincinine<i>-</i>19-Hydroxy-<i>O</i>-Acetyltransferase","year":2001,"lang":"en","type":"article","venue":"PLANT PHYSIOLOGY","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":99,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"Rice University","keywords":"Catharanthus roseus; Vindoline; Biochemistry; Acetyltransferase; Biosynthesis; Biology; Enzyme; Acetylation; Recombinant DNA; Gene","authors":[{"name":"Pierre Laflamme","is_ca":true},{"name":"Benoit St‐Pierre","is_ca":true},{"name":"Vincenzo De Luca","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05392429045324689,"gpt":0.3505377274544963,"spread":0.2966134370012494,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004685364,0.0004387385,0.001114723,0.0004349646,0.0001777741,0.00001093058,0.0004026397,0.0005857295,0.003166562],"category_scores_gemma":[0.00004629439,0.0004139362,0.0003595841,0.0007735596,0.0006690008,0.0000736212,0.0001347882,0.0006639855,0.00004195564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004689203,"about_ca_system_score_gemma":0.00007198263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006384312,"about_ca_topic_score_gemma":0.00003358669,"domain_scores_codex":[0.996985,0.0006651992,0.0006767494,0.0007618262,0.0001741415,0.0007370518],"domain_scores_gemma":[0.9980851,0.0008333942,0.0002072691,0.000369834,0.00009005732,0.0004143803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001460958,0.0005049795,0.01354534,0.00005318042,0.002314986,0.0001493651,0.0003946291,0.0009444773,0.9740057,0.001253247,0.004412248,0.0009609003],"study_design_scores_gemma":[0.004104983,0.0006156303,0.04592664,0.00001884643,0.004978667,0.0003291592,0.0002043542,0.009559168,0.6686499,0.0005773123,0.2638761,0.001159271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919669,0.004465567,0.0001609773,0.0006296338,0.0003798209,0.0003200276,0.0005932634,0.00007982618,0.001404007],"genre_scores_gemma":[0.9947426,0.002558934,0.0001111533,0.001793383,0.0001805003,0.00005983126,0.000433183,0.0000344315,0.00008596124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3053558,"threshold_uncertainty_score":0.9998313,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2025088826","doi":"10.1016/j.lfs.2005.04.042","title":"Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens","year":2005,"lang":"en","type":"article","venue":"Life Sciences","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":93,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Japan Society for the Promotion of Science; Pfizer","keywords":"Vas deferens; Prazosin; Contraction (grammar); Pharmacology; Alkaloid; Medicine; Muscle contraction; Tetrodotoxin; Stimulation; Chemistry; Internal medicine; Antagonist; Stereochemistry; Receptor","authors":[{"name":"Kenjiro Matsumoto","is_ca":false},{"name":"Leonardo T. Yamamoto","is_ca":false},{"name":"Kazuo Watanabe","is_ca":false},{"name":"Shingo Yano","is_ca":false},{"name":"Jie Shan","is_ca":true},{"name":"Peter K.T. Pang","is_ca":true},{"name":"Dhavadee Ponglux","is_ca":false},{"name":"Hiromitsu Takayama","is_ca":false},{"name":"Syunji Horie","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09029777392652863,"gpt":0.4178692286561881,"spread":0.3275714547296594,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001789992,0.0002511857,0.0004750403,0.0001348883,0.0003390182,0.000006964808,0.0006895699,0.0002577559,0.001585239],"category_scores_gemma":[0.0004160462,0.0001540885,0.0001770903,0.0004329004,0.001606734,0.0001851149,0.00005669068,0.0006609456,0.00003224239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003062869,"about_ca_system_score_gemma":0.0001628581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002096801,"about_ca_topic_score_gemma":0.0001320567,"domain_scores_codex":[0.996436,0.001782881,0.0005584959,0.0004322395,0.0004178736,0.0003725388],"domain_scores_gemma":[0.9959466,0.003056908,0.0004631443,0.0002580292,0.00006377032,0.0002115598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001216956,0.0006597528,0.1163449,0.00004613765,0.0003684957,0.00000547644,0.00135928,0.002873517,0.8403651,0.001323329,0.01175704,0.02367996],"study_design_scores_gemma":[0.002700099,0.002495185,0.1017752,0.00004872043,0.0006587157,0.00001147328,0.0002809773,0.003913779,0.8666574,0.000320265,0.02083827,0.0002999088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891196,0.001540953,0.000007492264,0.002632032,0.002075751,0.0003480814,0.00005234669,0.00003481,0.004188909],"genre_scores_gemma":[0.9951937,0.0002241928,0.00003721278,0.003513939,0.0009050854,0.00001843719,0.000005277637,0.00001290409,0.00008924795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02629228,"threshold_uncertainty_score":0.9993274,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2160561333","doi":"10.1093/pcp/pct040","title":"Coupling Deep Transcriptome Analysis with Untargeted Metabolic Profiling in Ophiorrhiza pumila to Further the Understanding of the Biosynthesis of the Anti-Cancer Alkaloid Camptothecin and Anthraquinones","year":2013,"lang":"en","type":"article","venue":"Plant and Cell Physiology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":91,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Phenomenome Discoveries (Canada)","funders":"Core Research for Evolutional Science and Technology; National Institute of General Medical Sciences; Japan Science and Technology Agency; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Camptothecin; Biology; Anthraquinones; Transcriptome; Biosynthesis; Metabolome; Metabolic pathway; Biochemistry; Gene; Botany; Gene expression; Metabolite","authors":[{"name":"Mami Yamazaki","is_ca":false},{"name":"Keiichi Mochida","is_ca":false},{"name":"Takashi Asano","is_ca":false},{"name":"Ryo Nakabayashi","is_ca":false},{"name":"Motoaki Chiba","is_ca":false},{"name":"Nirin Udomson","is_ca":false},{"name":"Yasuyo Yamazaki","is_ca":true},{"name":"Dayan B. Goodenowe","is_ca":true},{"name":"Ushio Sankawa","is_ca":false},{"name":"Atsushi Toyoda","is_ca":false},{"name":"Yasushi Totoki","is_ca":false},{"name":"Yoshiyuki Sakaki","is_ca":false},{"name":"Elsa Góngora‐Castillo","is_ca":false},{"name":"C. Robin Buell","is_ca":false},{"name":"Tetsuya Sakurai","is_ca":false},{"name":"Kazuki Saito","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04918967360532556,"gpt":0.3094593248404035,"spread":0.2602696512350779,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004733577,0.0002742566,0.0006771718,0.0001727597,0.0002736644,0.0000115455,0.0003947707,0.0002015706,0.0004836338],"category_scores_gemma":[0.00001729618,0.0001331172,0.0001390721,0.0007166046,0.0006480996,0.00006429008,0.0001132076,0.0004201845,0.000002076499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002288616,"about_ca_system_score_gemma":0.00004709941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004435213,"about_ca_topic_score_gemma":0.0003885395,"domain_scores_codex":[0.9981451,0.0005097096,0.000431733,0.0003619124,0.0001269424,0.0004246187],"domain_scores_gemma":[0.9984808,0.000856981,0.0002827424,0.0002433615,0.00005367877,0.00008245589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002946327,0.0001192884,0.1109713,0.00007528422,0.000652099,6.43339e-7,0.002024417,0.003791788,0.8814969,0.000388247,0.00003426426,0.0001511513],"study_design_scores_gemma":[0.001152383,0.00008870962,0.2029476,0.00003867988,0.001643648,0.000006686172,0.00343014,0.01289459,0.776756,0.0003167742,0.0004189041,0.0003058421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947283,0.002665265,0.00004817893,0.001268301,0.0002361509,0.0008002323,0.0001230869,0.00001032551,0.0001201183],"genre_scores_gemma":[0.9974226,0.001835576,0.00003362855,0.0004940795,0.00005543256,0.00009633685,0.000005573198,0.00002094089,0.00003579842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1047409,"threshold_uncertainty_score":0.5428361,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1994226956","doi":"10.1021/ol061698+","title":"Expanding the Scope of Mn(OAc)<sub>3</sub>-Mediated Cyclizations:  Synthesis of the Tetracyclic Core of Tronocarpine","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":89,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Acetonitrile; Indole test; Substrate (aquarium); Nitrogen atom; Combinatorial chemistry; Scope (computer science); Core (optical fiber); Medicinal chemistry; Stereochemistry; Ring (chemistry); Organic chemistry","authors":[{"name":"Jakob Magolan","is_ca":true},{"name":"Michael A. Kerr","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04036890329457047,"gpt":0.3282100816290675,"spread":0.287841178334497,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007484961,0.0002631172,0.0005086603,0.0001339424,0.0002439474,0.00000672925,0.0007141525,0.0002163003,0.0008144637],"category_scores_gemma":[0.000362998,0.0001771206,0.0002312507,0.0006771211,0.0008498295,0.00008452243,0.000135312,0.000492685,0.00002832599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007729118,"about_ca_system_score_gemma":0.0001112026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005141029,"about_ca_topic_score_gemma":0.00004257978,"domain_scores_codex":[0.9975871,0.0006445017,0.0008448901,0.0002753256,0.0002487429,0.0003994291],"domain_scores_gemma":[0.9964181,0.002243443,0.000755501,0.0004184092,0.00009992637,0.00006465209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009669093,0.0002542052,0.01327628,0.00008469968,0.0002672189,0.000003184687,0.0002099913,0.0003612745,0.9734781,0.0001964719,0.01031671,0.001455121],"study_design_scores_gemma":[0.000750216,0.00003562737,0.01622743,0.00005096262,0.0004758183,0.00001212789,0.00009175862,0.0001089814,0.9804145,0.00008874528,0.001575919,0.000167933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935582,0.0009553375,0.000136958,0.003442637,0.000752768,0.0004962078,0.0001756131,0.00003251444,0.000449783],"genre_scores_gemma":[0.9971721,0.0005674391,0.00003162632,0.001892169,0.000202418,0.00004527406,0.0000219119,0.00004519495,0.00002190828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008740796,"threshold_uncertainty_score":0.8917807,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2025885407","doi":"10.1007/s00210-003-0854-9","title":"In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel)","year":2004,"lang":"en","type":"article","venue":"Naunyn-Schmiedeberg s Archives of Pharmacology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":77,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"","keywords":"Chemistry; Pharmacology; Traditional medicine; Medicine","authors":[{"name":"Wenbo Zhang","is_ca":true},{"name":"Chen Chang-xun","is_ca":false},{"name":"Si Mui Sim","is_ca":false},{"name":"Chiu‐Yin Kwan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02451617320406071,"gpt":0.3249419507691891,"spread":0.3004257775651284,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001163622,0.0007514093,0.001520779,0.0004183713,0.0003073906,0.00001331849,0.001682091,0.0007693479,0.0009569807],"category_scores_gemma":[0.0001974559,0.0005437124,0.0005496888,0.0009130335,0.002235541,0.0001993055,0.0007386244,0.002065829,0.00001447535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009133058,"about_ca_system_score_gemma":0.0005376437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000913201,"about_ca_topic_score_gemma":0.000171867,"domain_scores_codex":[0.993619,0.002132661,0.001971511,0.0008838549,0.0004249921,0.0009680432],"domain_scores_gemma":[0.9934264,0.004145986,0.001351563,0.0005954689,0.0002074713,0.0002731548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005727171,0.001188643,0.001361113,0.0001473954,0.0009829518,0.00002833258,0.002305225,0.002609603,0.9759406,0.004136175,0.0009902398,0.004582502],"study_design_scores_gemma":[0.009856724,0.0004967937,0.004717674,0.000079838,0.0007334017,0.00002588736,0.0001757005,0.002524137,0.9430802,0.03226087,0.005570326,0.0004784565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823368,0.003417937,0.001244817,0.006171481,0.002541764,0.001819686,0.0007306231,0.00005188537,0.001685021],"genre_scores_gemma":[0.9903067,0.002291468,0.001593841,0.004891685,0.0004497246,0.000147224,0.00004110333,0.00008652919,0.0001916886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03286045,"threshold_uncertainty_score":0.9999563,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2119118505","doi":"10.1021/jo049703f","title":"A Modular and Concise Total Synthesis of (±)-Daurichromenic Acid and Analogues","year":2004,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":75,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Modular design; Chemistry; Computer science; Programming language","authors":[{"name":"Hongjuan Hu","is_ca":true},{"name":"Tyler Harrison","is_ca":true},{"name":"Peter D. Wilson","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03471040337878247,"gpt":0.3372351534014122,"spread":0.3025247500226298,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00106247,0.0001876853,0.0004341663,0.0000393385,0.0001350515,0.000008963792,0.000261069,0.0002221839,0.001370025],"category_scores_gemma":[0.000203785,0.0001340417,0.00008460545,0.00012947,0.0004907539,0.00008087292,0.0001095742,0.0006049442,0.000004462838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000621887,"about_ca_system_score_gemma":0.0001685949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005417558,"about_ca_topic_score_gemma":0.000001517139,"domain_scores_codex":[0.9987974,0.000187108,0.0004992411,0.0001276225,0.0001518031,0.0002367866],"domain_scores_gemma":[0.9984879,0.0005943466,0.0004676706,0.0001393898,0.0001181704,0.0001925607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003376249,0.0001395178,0.0007213077,0.0001047811,0.0004081024,0.00003765777,0.0006959642,0.00006930718,0.9950082,0.00001541015,0.0001597137,0.002302456],"study_design_scores_gemma":[0.001453719,0.0001119922,0.002025184,0.00003928995,0.0007582931,0.001946385,0.000446353,0.00005354412,0.991896,0.0004977832,0.0006276619,0.0001437483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914585,0.006978832,0.00008930393,0.0009089353,0.000143628,0.00007971707,0.00001932368,0.000009299863,0.0003124032],"genre_scores_gemma":[0.9960029,0.003363222,0.0001230913,0.0002069157,0.0002176862,0.000002107298,7.912282e-7,0.00001894689,0.00006434401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004544339,"threshold_uncertainty_score":0.9995428,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2064807312","doi":"10.1016/j.jep.2006.03.018","title":"Changes in chromosome structure, mitotic activity and nuclear DNA content from cells of Allium Test induced by bark water extract of Uncaria tomentosa (Willd.) DC","year":2006,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":72,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Trent University","funders":"","keywords":"Incubation; Allium; Mitotic index; Distilled water; Incubation period; Mitosis; Bark (sound); Chemistry; Biology; Botany; Traditional medicine; Biochemistry; Chromatography; Medicine","authors":[{"name":"Mieczysław Kuraś","is_ca":false},{"name":"Julita Nowakowska","is_ca":false},{"name":"Elwira Śliwińska","is_ca":false},{"name":"Radosław Pilarski","is_ca":false},{"name":"Renata Ilasz","is_ca":false},{"name":"Teresa Tykarska","is_ca":false},{"name":"Alicja M. Zobel","is_ca":true},{"name":"Krzysztof Gulewicz","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06863866136667386,"gpt":0.35286219287711,"spread":0.2842235315104361,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001174291,0.0004838853,0.001401138,0.0004635208,0.0001121524,0.00001515992,0.0005461151,0.0008600817,0.004306487],"category_scores_gemma":[0.00008405006,0.0003900856,0.0002093297,0.0002396591,0.0005504939,0.0002454898,0.0001882851,0.001683535,0.000009505008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001741433,"about_ca_system_score_gemma":0.0001242334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005384934,"about_ca_topic_score_gemma":0.0002539036,"domain_scores_codex":[0.9958814,0.001232293,0.001369699,0.0004314766,0.0003383126,0.0007467887],"domain_scores_gemma":[0.9959034,0.001988398,0.001321694,0.0001853415,0.0003025494,0.0002986144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001887106,0.001621192,0.006504729,0.0001109437,0.0006116268,0.000144664,0.0008423233,0.00009731803,0.982058,0.00002333168,0.004257828,0.001840972],"study_design_scores_gemma":[0.005992217,0.001050487,0.02227092,0.00003677985,0.0006844549,0.00003084221,0.0001609878,0.0002515284,0.9617301,0.000282113,0.007169107,0.0003404549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931121,0.00140335,0.000004996414,0.001576048,0.002751154,0.0004840177,0.0004524759,0.00001550276,0.0002003611],"genre_scores_gemma":[0.9972478,0.0009053464,0.0001189212,0.0009626926,0.0005939438,0.00001043404,0.00001669587,0.00005529448,0.00008888364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02032786,"threshold_uncertainty_score":0.9998551,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1861255592","doi":"10.1002/ptr.4614","title":"Rhynchophylline Attenuates LPS‐induced Pro‐inflammatory Responses through Down‐regulation of MAPK/NF‐κB Signaling Pathways in Primary Microglia","year":2012,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":67,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Winnipeg; University of Manitoba","funders":"China Pharmaceutical University","keywords":"Microglia; Neuroinflammation; MAPK/ERK pathway; Pharmacology; Nitric oxide; Tumor necrosis factor alpha; Phosphorylation; NF-κB; Proinflammatory cytokine; Chemistry; Kinase; Signal transduction; Lipopolysaccharide; Cell biology; Biology; Inflammation; Immunology; Endocrinology","authors":[{"name":"Yu Na Song","is_ca":false},{"name":"Rong Qu","is_ca":false},{"name":"Shenghua Zhu","is_ca":true},{"name":"Ruiguo Zhang","is_ca":true},{"name":"Shiping Ma","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3007529896400827,"gpt":0.4816966463886864,"spread":0.1809436567486037,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007004633,0.000385193,0.000649051,0.0005394683,0.0003568263,0.00002643887,0.0005584695,0.0006091337,0.003151636],"category_scores_gemma":[0.0001761661,0.0003629089,0.0001877704,0.0007933715,0.0005394951,0.0004516917,0.0001378091,0.001633536,0.0002176461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003087028,"about_ca_system_score_gemma":0.0003437884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007068127,"about_ca_topic_score_gemma":0.00001696866,"domain_scores_codex":[0.992716,0.00376172,0.0009228878,0.0005369568,0.0006352428,0.001427174],"domain_scores_gemma":[0.9958481,0.002780284,0.0002958652,0.0004206942,0.0003907547,0.0002642595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004138215,0.001090198,0.0614695,0.0002113697,0.0001904467,0.00001557358,0.004145784,0.00008174017,0.9135543,0.0007505547,0.001500685,0.01285163],"study_design_scores_gemma":[0.00251348,0.0003265369,0.0513807,0.00006535858,0.00003324814,0.00001208233,0.0002260877,0.0002139912,0.9168602,0.001538054,0.02646956,0.000360664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888359,0.00574854,0.00003324696,0.0007587717,0.0005938272,0.001331347,0.00007967837,0.00007205366,0.00254661],"genre_scores_gemma":[0.9952692,0.00125182,0.0004930093,0.0007409161,0.001023115,0.0003253258,0.00004097959,0.00008730355,0.0007683143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02496887,"threshold_uncertainty_score":0.9998823,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2125543056","doi":"10.1186/s12864-015-1678-y","title":"Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome","year":2015,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":67,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Catharanthus roseus; Transcriptome; Biology; De novo transcriptome assembly; Gene isoform; Computational biology; Secondary metabolism; Gene; Sequence assembly; Genetics; Biochemistry; Biosynthesis; Gene expression","authors":[{"name":"Thomas Dugé de Bernonville","is_ca":false},{"name":"Emilien Foureau","is_ca":false},{"name":"Claire Parage","is_ca":false},{"name":"Arnaud Lanoue","is_ca":false},{"name":"Marc Clastre","is_ca":false},{"name":"Monica Arias Londono","is_ca":false},{"name":"Audrey Oudin","is_ca":false},{"name":"Benjamin Houillé","is_ca":false},{"name":"Nicolas Papon","is_ca":false},{"name":"Sébastien Besseau","is_ca":false},{"name":"Gaëlle Glévarec","is_ca":false},{"name":"Lucía Atehortúa","is_ca":false},{"name":"Nathalie Giglioli‐Guivarc’h","is_ca":false},{"name":"Benoit St‐Pierre","is_ca":false},{"name":"Vincenzo De Luca","is_ca":true},{"name":"Sarah E. O’Connor","is_ca":false},{"name":"Vincent Courdavault","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07580556149501023,"gpt":0.3488025469145888,"spread":0.2729969854195786,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002209939,0.0004572876,0.0009367248,0.0002775457,0.000167633,0.00002203905,0.0004494248,0.0007074084,0.001134155],"category_scores_gemma":[0.0002456977,0.0004866658,0.0001645789,0.0003032373,0.0003683307,0.0002395126,0.0001388322,0.000649041,0.00002545882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000296714,"about_ca_system_score_gemma":0.0009980608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004996752,"about_ca_topic_score_gemma":0.0008363522,"domain_scores_codex":[0.9965856,0.0007066062,0.001079687,0.0006554704,0.0001835292,0.000789097],"domain_scores_gemma":[0.9976774,0.0005302096,0.0007530424,0.0003381706,0.0002616538,0.0004394559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001424958,0.0006289633,0.006827389,0.0003781879,0.0002730632,0.00002169707,0.01329728,0.0002628143,0.9749145,0.0001318397,0.0002179108,0.001621431],"study_design_scores_gemma":[0.004183834,0.0007224802,0.0270195,0.00002231067,0.0003768039,0.0001129401,0.0009191509,0.002038316,0.9576489,0.00009142649,0.006387152,0.000477128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943999,0.0003918716,0.001476334,0.0001136869,0.001038437,0.001113105,0.0005435139,0.00007334719,0.0008498274],"genre_scores_gemma":[0.9967407,0.0002295976,0.001310497,0.0006033156,0.0002416058,0.0001079679,0.00009662514,0.00007606809,0.0005935951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02019211,"threshold_uncertainty_score":0.9997789,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2072319732","doi":"10.1016/j.jep.2009.12.004","title":"Uncaria tomentosa acts as a potent TNF-α inhibitor through NF-κB","year":2009,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":67,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"NOSM University; University of Ottawa; Laurentian University; Sudbury Regional Hospital","funders":"","keywords":"NF-κB; Cytokine; Tumor necrosis factor alpha; Monocyte; NFKB1; Pharmacology; Mechanism of action; Proinflammatory cytokine; Biology; THP1 cell line; Cell culture; Transcription factor; Traditional medicine; Medicine; Inflammation; Immunology; Biochemistry; In vitro; Gene","authors":[{"name":"Lisa Allen-Hall","is_ca":true},{"name":"John T. Arnason","is_ca":true},{"name":"Pablo Cano","is_ca":true},{"name":"Robert M. Lafrenie","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1255574060194858,"gpt":0.4768655164013623,"spread":0.3513081103818766,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002694455,0.0007371425,0.00138331,0.0005365143,0.0005009358,0.00005705263,0.001193088,0.001184241,0.00964927],"category_scores_gemma":[0.0004043177,0.0006501265,0.0006855404,0.0006770288,0.0004860578,0.0006731683,0.0001870951,0.003488049,0.0006791353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004510584,"about_ca_system_score_gemma":0.000735693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001782265,"about_ca_topic_score_gemma":0.000004946622,"domain_scores_codex":[0.9934217,0.001901801,0.00196308,0.0006167016,0.0006506993,0.001446068],"domain_scores_gemma":[0.9951235,0.001307155,0.001608297,0.0003209907,0.0007178884,0.0009221387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003765509,0.001850298,0.0003524842,0.00003635387,0.001053884,0.001729234,0.00187767,0.0005853093,0.8278179,0.002951322,0.1314385,0.02654151],"study_design_scores_gemma":[0.007073329,0.002574613,0.0008527855,0.00003375644,0.001094276,0.0006736797,0.0003004387,0.0001660187,0.4615143,0.005735644,0.5193979,0.0005832004],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9293389,0.004758351,0.000201393,0.0239666,0.01449979,0.000753163,0.00003764395,0.0001246478,0.02631952],"genre_scores_gemma":[0.9519788,0.002584017,0.0008005782,0.03913661,0.003767601,0.00002701054,0.000009482183,0.00006409091,0.001631818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3879594,"threshold_uncertainty_score":0.999595,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2770928412","doi":"10.1007/s00425-017-2812-7","title":"Geissoschizine synthase controls flux in the formation of monoterpenoid indole alkaloids in a Catharanthus roseus mutant","year":2017,"lang":"en","type":"article","venue":"Planta","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":67,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Grain Farmers of Ontario; Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Compute Canada; Genome Canada; Canada Excellence Research Chairs, Government of Canada; McGill University; Ontario Innovation Trust","keywords":"Vindoline; Catharanthus roseus; Mutant; Biochemistry; ATP synthase; Indole alkaloid; Biology; Enzyme; Indole test; Vinblastine; Gene; Genetics","authors":[{"name":"Yang Qu","is_ca":true},{"name":"Antje M. K. Thamm","is_ca":false},{"name":"Matthew Czerwinski","is_ca":true},{"name":"Sayaka Masada","is_ca":false},{"name":"Kyung‐Hee Kim","is_ca":true},{"name":"Graham Jones","is_ca":true},{"name":"Ping Liang","is_ca":true},{"name":"Vincenzo De Luca","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09787411334531533,"gpt":0.4078856207168824,"spread":0.3100115073715671,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002136398,0.0002740111,0.0005696898,0.0002207724,0.000327167,0.00004993603,0.001018845,0.0003425462,0.0005213566],"category_scores_gemma":[0.0003117307,0.0002113676,0.0001101393,0.0001159845,0.0002710425,0.0003306984,0.0001187554,0.0008540842,0.0001023103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007041393,"about_ca_system_score_gemma":0.00008257895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006026046,"about_ca_topic_score_gemma":0.0008695513,"domain_scores_codex":[0.9973953,0.0007787024,0.0007637509,0.0003024358,0.0001996216,0.0005601828],"domain_scores_gemma":[0.9978038,0.00107799,0.0005052944,0.0004658388,0.00004408799,0.0001029784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006995553,0.00247544,0.06723122,0.0002757895,0.0002123384,0.001074506,0.01141677,0.0004969929,0.859942,0.001290329,0.004585627,0.04400344],"study_design_scores_gemma":[0.02172957,0.0006619113,0.2122208,0.0002371345,0.000468152,0.0005736356,0.001014298,0.03736105,0.6648815,0.001794742,0.05797385,0.001083359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907253,0.0007464232,0.00003188515,0.001512453,0.0005940957,0.0008657633,0.0003693305,0.00002844687,0.005126283],"genre_scores_gemma":[0.9977423,0.0005545708,0.00002609818,0.001191045,0.0001645704,0.0001545665,0.00006768374,0.00001901202,0.00008015546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1950605,"threshold_uncertainty_score":0.8619322,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2048942191","doi":"10.1016/j.phytochem.2006.05.018","title":"Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling","year":2006,"lang":"en","type":"article","venue":"Phytochemistry","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":64,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"Brock University","keywords":"Vindoline; Catharanthus roseus; Vinca; Biology; Cultivar; Botany; Alkaloid; Apocynaceae; Vinblastine","authors":[{"name":"Mary Magnotta","is_ca":true},{"name":"Jun Murata","is_ca":true},{"name":"Jianxin Chen","is_ca":true},{"name":"Vincenzo De Luca","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03337935954202638,"gpt":0.3772700846414213,"spread":0.3438907250993949,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006262746,0.0002469147,0.0004482825,0.00005594535,0.0001213118,0.00001035678,0.0002273932,0.0003129582,0.000235376],"category_scores_gemma":[0.0001401334,0.0002523721,0.0001011903,0.0001753671,0.000292748,0.00009198482,0.00007084159,0.0003877422,0.000005326774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003858855,"about_ca_system_score_gemma":0.00005804261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005713357,"about_ca_topic_score_gemma":0.000001967782,"domain_scores_codex":[0.9980566,0.0001613196,0.000920509,0.0003582881,0.0001712091,0.0003320733],"domain_scores_gemma":[0.9983751,0.0004590394,0.0007006304,0.0002165367,0.0001522496,0.00009643075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001939364,0.0004543244,0.009277125,0.000893462,0.00009372013,0.0000030233,0.0001999876,0.0002908713,0.9862506,0.00005524962,0.0008404351,0.0014473],"study_design_scores_gemma":[0.001202407,0.00003161947,0.001326576,0.0000525924,0.0001518865,0.00001492152,0.0000968145,0.006814597,0.9894013,0.000249842,0.0004415878,0.0002158502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953033,0.002631024,0.0003252207,0.00008601548,0.00016798,0.0003847475,0.0002001942,0.00004106857,0.0008604966],"genre_scores_gemma":[0.9988355,0.0001367033,0.0002534711,0.00006939392,0.0002101305,0.00006683136,0.0001077622,0.00002712414,0.0002930782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007950549,"threshold_uncertainty_score":0.9999928,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2021339532","doi":"10.1021/ol017014+","title":"Concise Synthesis and Transannular Inverse Electron Demand Diels−Alder Reaction of [3](3,6)Pyridazino[3](1,3)indolophane. Rapid Access to a Pentacyclic Indoloid System","year":2001,"lang":"en","type":"article","venue":"Organic Letters","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":62,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Indole test; Diels–Alder reaction; Stereochemistry; Inverse; Hydroboration; Combinatorial chemistry; Organic chemistry; Catalysis","authors":[{"name":"Graham J. Bodwell","is_ca":true},{"name":"Jiang Li","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05927132620763598,"gpt":0.3558475530784411,"spread":0.2965762268708051,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001081422,0.0004808767,0.000787779,0.0003738355,0.0003162397,0.00004668156,0.0005615035,0.0004507456,0.001683055],"category_scores_gemma":[0.0001286489,0.0004723461,0.0001675202,0.0005534131,0.0002620437,0.0003883397,0.0001343007,0.0007220978,0.0001528022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647285,"about_ca_system_score_gemma":0.00008874403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007984691,"about_ca_topic_score_gemma":0.00005947218,"domain_scores_codex":[0.9964147,0.001052628,0.0007257521,0.0007058922,0.0002703239,0.0008307223],"domain_scores_gemma":[0.9978819,0.0008798885,0.000341513,0.0003512042,0.00008992934,0.0004554966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001360059,0.0002036952,0.007050447,0.0001927141,0.0004653791,0.000154393,0.0009412584,0.00004184047,0.9763348,0.00003931161,0.008957615,0.004258495],"study_design_scores_gemma":[0.002286383,0.0002159925,0.008454463,0.00006744846,0.0008198969,0.0003491874,0.000278247,0.0001915227,0.9611897,0.00001024512,0.0255889,0.0005479848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905347,0.0006455249,0.0003395199,0.005968203,0.0008757347,0.0009897409,0.00003556587,0.0001475243,0.0004635328],"genre_scores_gemma":[0.9879136,0.001250392,0.00005346856,0.01013036,0.0003466485,0.0001628083,0.00001267062,0.00007783826,0.00005222408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01663129,"threshold_uncertainty_score":0.9997728,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2907450060","doi":"10.1056/nejmc1811055","title":"Deaths in Colorado Attributed to Kratom","year":2019,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":60,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Office of the Chief Medical Examiner","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences","keywords":"Medicine; MEDLINE; Environmental health; Gerontology; Law","authors":[{"name":"Ken Gershman","is_ca":false},{"name":"Krista Timm","is_ca":true},{"name":"Meredith Frank","is_ca":true},{"name":"Laurissa Lampi","is_ca":false},{"name":"Jonathan Melamed","is_ca":false},{"name":"Roy Gerona","is_ca":false},{"name":"Andrew A. Monte","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.141728266256657,"gpt":0.4387886758592984,"spread":0.2970604096026414,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00376147,0.0005987654,0.001946406,0.001038688,0.00007981368,0.00001517921,0.0009236544,0.001708593,0.009296382],"category_scores_gemma":[0.0008044786,0.0004461101,0.0002229715,0.0005375346,0.000191807,0.0001027221,0.0001034003,0.007813014,0.0004487875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002988957,"about_ca_system_score_gemma":0.0006864819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001497848,"about_ca_topic_score_gemma":0.00006837428,"domain_scores_codex":[0.9946864,0.001801642,0.001586123,0.0004220934,0.0006312116,0.0008725293],"domain_scores_gemma":[0.9943091,0.003560269,0.0009668638,0.0002915157,0.000357737,0.0005145324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001614555,0.00009569427,0.003192341,0.00010544,0.0004841722,0.004424615,0.0008007497,0.0002426159,0.004199557,0.00001775136,0.9576887,0.02713378],"study_design_scores_gemma":[0.0337934,0.001639978,0.0007882832,0.0003227245,0.0007032666,0.001130061,0.000043252,0.00004829557,0.0006555456,0.0002854934,0.9601902,0.0003995456],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04466477,0.004432378,0.0001890665,0.9329886,0.0126452,0.0007721164,0.0000731715,0.00002886629,0.004205783],"genre_scores_gemma":[0.04498444,0.001479564,0.0001955248,0.9016083,0.04316892,0.00001265939,0.00008780564,0.00009718467,0.008365598],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03217884,"threshold_uncertainty_score":0.9997991,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2007273075","doi":"10.1016/j.jep.2006.07.039","title":"Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1β and TNF-α","year":2006,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":60,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"NOSM University; University of Ottawa; Laurentian University; Sudbury Regional Hospital","funders":"","keywords":"THP1 cell line; Cytokine; Traditional medicine; Immune system; Tumor necrosis factor alpha; Biology; Monocyte; Pharmacology; Cell culture; Medicine; Immunology","authors":[{"name":"Lisa Allen-Hall","is_ca":true},{"name":"Pablo Cano","is_ca":true},{"name":"John T. Arnason","is_ca":true},{"name":"Rosario Rojas","is_ca":false},{"name":"Olga Lock de Ugaz","is_ca":false},{"name":"Robert M. Lafrenie","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05315147605278987,"gpt":0.3750912771239115,"spread":0.3219398010711217,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008499134,0.0004805403,0.0009379453,0.0002779458,0.0003413137,0.00002910008,0.0004663184,0.0004856449,0.001698895],"category_scores_gemma":[0.00002431257,0.0002813383,0.0002518134,0.0002414575,0.0008185227,0.0001978274,0.00009981313,0.0008134849,0.00001157257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001376168,"about_ca_system_score_gemma":0.0002278349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006971398,"about_ca_topic_score_gemma":0.00002988158,"domain_scores_codex":[0.9962057,0.001309071,0.001145608,0.0003604235,0.0003364741,0.0006427399],"domain_scores_gemma":[0.995845,0.001907218,0.001398005,0.0002235206,0.000337538,0.0002887725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003644268,0.001604047,0.003595593,0.00005097581,0.000788186,0.0002863409,0.0009937258,0.001414939,0.9691755,0.0002547804,0.009701305,0.008490347],"study_design_scores_gemma":[0.007105021,0.002334904,0.00988544,0.00002923675,0.001522708,0.0002316106,0.0002089523,0.0003358658,0.9063434,0.0005953104,0.07110753,0.0003000305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896407,0.003814678,0.00009450053,0.002443542,0.002379116,0.0005703343,0.00006677343,0.0000249415,0.0009654402],"genre_scores_gemma":[0.9941474,0.002866236,0.0003930261,0.0005435823,0.001012769,0.00003684613,0.000008194311,0.00004534361,0.0009466335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06283209,"threshold_uncertainty_score":0.9999639,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2913104877","doi":"10.1021/acs.orglett.9b00230","title":"Alstonlarsines A–D, Four Rearranged Indole Alkaloids from <i>Alstonia scholaris</i>","year":2019,"lang":"en","type":"article","venue":"Organic Letters","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":53,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Science and Technology Commission of Shanghai Municipality; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Chemistry; Indole test; Stereochemistry; Apocynaceae; Botany; Biology","authors":[{"name":"Xu-Xin Zhu","is_ca":false},{"name":"Yao‐Yue Fan","is_ca":false},{"name":"Lei Xu","is_ca":false},{"name":"Qun‐Fang Liu","is_ca":false},{"name":"Jiangping Wu","is_ca":true},{"name":"Jing-Ya Li","is_ca":false},{"name":"Jia Li","is_ca":false},{"name":"Kun Gao","is_ca":false},{"name":"Jian‐Min Yue","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05507918674045744,"gpt":0.34537560006714,"spread":0.2902964133266826,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001243774,0.000525117,0.0007621671,0.0001823753,0.0003505056,0.00007606103,0.0008214999,0.0006871537,0.0296612],"category_scores_gemma":[0.0002002011,0.0005114982,0.0002598447,0.0004206011,0.0002318468,0.0003742357,0.0002150346,0.00177258,0.009084716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089358,"about_ca_system_score_gemma":0.0001476396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001801755,"about_ca_topic_score_gemma":0.00004095379,"domain_scores_codex":[0.9960613,0.0009132271,0.000892689,0.0008388704,0.0003427629,0.0009511614],"domain_scores_gemma":[0.9976172,0.0007549772,0.0005824832,0.0005628534,0.00009832376,0.0003841815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000290721,0.0001623867,0.04361066,0.0000243313,0.0003881596,0.00008390706,0.0004816739,0.00002949398,0.8832743,0.00006062245,0.06811007,0.00348374],"study_design_scores_gemma":[0.003927191,0.0001032661,0.01902567,0.00002781397,0.0003570139,0.00007775261,0.00009882179,0.0001695058,0.6598083,0.0001804308,0.3154496,0.0007746843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777701,0.0008584828,0.0001283419,0.01404396,0.004330593,0.0006489446,0.0001240161,0.0002762611,0.001819318],"genre_scores_gemma":[0.943441,0.0001927273,0.0003644732,0.0534744,0.001047933,0.00004109338,0.00009098637,0.0001190985,0.001228237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2473395,"threshold_uncertainty_score":0.9997337,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2201429228","doi":"10.1111/ggi.12696","title":"Randomized double‐blind placebo‐controlled multicenter trial of <scp>Y</scp>okukansan for neuropsychiatric symptoms in <scp>A</scp>lzheimer's disease","year":2015,"lang":"en","type":"article","venue":"Geriatrics and gerontology international/Geriatrics & gerontology international","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institute of Aging","funders":"","keywords":"Medicine; Placebo; Randomized controlled trial; Adverse effect; Internal medicine; Dementia; Psychiatry; Physical therapy; Disease","authors":[{"name":"Katsutoshi Furukawa","is_ca":true},{"name":"Naoki Tomita","is_ca":true},{"name":"Daisuke Uematsu","is_ca":false},{"name":"Kazunori Okahara","is_ca":false},{"name":"Hiroyuki Shimada","is_ca":false},{"name":"Masaki Ikeda","is_ca":false},{"name":"Toshifumi Matsui","is_ca":false},{"name":"Koichi Kozaki","is_ca":false},{"name":"Masahiko Fujii","is_ca":false},{"name":"T Ogawa","is_ca":false},{"name":"Hiroyuki Umegaki","is_ca":false},{"name":"Katsuya Urakami","is_ca":false},{"name":"Hiroshi Nomura","is_ca":false},{"name":"Naoto Kobayashi","is_ca":false},{"name":"Aki Nakanishi","is_ca":false},{"name":"Yukihiro Washimi","is_ca":false},{"name":"Hisashi Yonezawa","is_ca":false},{"name":"Satoshi Takahashi","is_ca":false},{"name":"Masaharu Kubota","is_ca":false},{"name":"Yosuke Wakutani","is_ca":false},{"name":"Daisuke Ito","is_ca":false},{"name":"Takahiro Sasaki","is_ca":false},{"name":"Etsuro Matsubara","is_ca":false},{"name":"Kaori Une","is_ca":true},{"name":"Aiko Ishiki","is_ca":true},{"name":"Yukie Yahagi","is_ca":false},{"name":"Mikio Shoji","is_ca":false},{"name":"Hiroyasu Sato","is_ca":false},{"name":"Yasuo Terayama","is_ca":false},{"name":"Masafumi Kuzuya","is_ca":false},{"name":"Nobuo Araki","is_ca":false},{"name":"Manabu Kodama","is_ca":false},{"name":"Takuhiro Yamaguchi","is_ca":false},{"name":"Hiroyuki Arai","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1061387642271851,"gpt":0.4085650832478415,"spread":0.3024263190206564,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.005146536,0.001093199,0.00271308,0.002039359,0.0002855223,0.0001411058,0.001822027,0.001447491,0.0003749849],"category_scores_gemma":[0.00836356,0.001057588,0.001007552,0.000584768,0.0009438611,0.000536797,0.0004868069,0.001345834,0.00007640575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003831389,"about_ca_system_score_gemma":0.0006593953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001861609,"about_ca_topic_score_gemma":0.0002372195,"domain_scores_codex":[0.9906128,0.002084957,0.003309781,0.001644565,0.0008859537,0.001461933],"domain_scores_gemma":[0.9806886,0.01391889,0.002442631,0.0005547942,0.001455708,0.0009393864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9142656,0.003596366,0.01579064,0.0001086271,0.005809794,0.0001739378,0.003334769,0.001487814,0.000434467,0.02001115,0.03270888,0.002277926],"study_design_scores_gemma":[0.875995,0.0006994965,0.001384475,0.00001665814,0.002137586,0.00009118233,0.0006270913,0.01798544,0.0001792584,0.003184155,0.09734155,0.0003580992],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9328261,0.008376608,0.003107314,0.003625351,0.03351829,0.006735013,0.0006199356,0.0001533058,0.01103811],"genre_scores_gemma":[0.9820582,0.003618869,0.001529031,0.001762667,0.003383803,0.003030041,0.0006301016,0.0001365333,0.003850716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06463267,"threshold_uncertainty_score":0.9999894,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2003123528","doi":"10.1016/j.npep.2013.10.011","title":"Microtubule-stabilizing peptides and small molecules protecting axonal transport and brain function: Focus on davunetide (NAP)","year":2013,"lang":"en","type":"review","venue":"Neuropeptides","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":51,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Friends of Tel Aviv University","keywords":"Nap; Microtubule; Neuroprotection; Tauopathy; Neuroscience; Biology; Cell biology; Medicine; Neurodegeneration; Disease; Pathology","authors":[{"name":"Iddo Magen","is_ca":false},{"name":"Illana Gozes","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1905357010482244,"gpt":0.4042505303485365,"spread":0.2137148293003121,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001401002,0.001231302,0.002007546,0.0003810968,0.0009243739,0.0001169308,0.0004666751,0.0009501147,0.001126707],"category_scores_gemma":[0.0003071379,0.001041364,0.0004464036,0.0003018694,0.0006506444,0.00016254,0.0002261822,0.003311101,0.0002363783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007652933,"about_ca_system_score_gemma":0.0001853886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006422126,"about_ca_topic_score_gemma":0.00006549388,"domain_scores_codex":[0.9934956,0.002614922,0.001205631,0.001485007,0.0002290683,0.0009697129],"domain_scores_gemma":[0.9949178,0.003407397,0.0006436628,0.0004028837,0.0001126055,0.0005157177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002116966,0.000197657,0.0002004175,0.007118119,0.000565677,0.0001796718,0.0002597757,0.00001673551,0.003567963,0.000364201,0.002349565,0.9849685],"study_design_scores_gemma":[0.0008025446,0.0006453054,0.0002239959,0.001853399,0.001574712,0.0004262375,0.00007836772,0.00005649445,0.00065158,0.0001862239,0.9925043,0.0009968554],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02137597,0.9690589,0.00005101924,0.0004842025,0.0008929779,0.0035489,0.0001517652,0.0002548427,0.004181437],"genre_scores_gemma":[0.00481743,0.9891261,0.0004446279,0.002130819,0.0009124877,0.0009734627,0.00005731227,0.0002688195,0.001268959],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9901547,"threshold_uncertainty_score":0.9997864,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3036488677","doi":"10.1021/jacs.0c05042","title":"Synthesis of (−)-Picrotoxinin by Late-Stage Strong Bond Activation","year":2020,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":51,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Arnold and Mabel Beckman Foundation","keywords":"Chemistry; Geminal; Stereochemistry; Stereoselectivity; Bicyclic molecule; Lactone; Organic chemistry; Catalysis","authors":[{"name":"Steven W. M. Crossley","is_ca":false},{"name":"Guanghu Tong","is_ca":false},{"name":"Michael J. Lambrecht","is_ca":false},{"name":"Hannah E. Burdge","is_ca":false},{"name":"Ryan A. Shenvi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06488983335881625,"gpt":0.3802967957885881,"spread":0.3154069624297718,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005463329,0.0001937101,0.0005788468,0.00001495828,0.0001101198,0.000009536685,0.0006262579,0.000168293,0.0005883699],"category_scores_gemma":[0.0003548214,0.0001381234,0.0006202466,0.0003307675,0.0006768521,0.000101187,0.000136631,0.001116363,0.000006412939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069059,"about_ca_system_score_gemma":0.0001110017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001839889,"about_ca_topic_score_gemma":1.522718e-7,"domain_scores_codex":[0.9983069,0.0003175435,0.0006289495,0.0001735482,0.0002705796,0.0003024644],"domain_scores_gemma":[0.9970022,0.001044253,0.001464977,0.0001238193,0.0001248833,0.0002398712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00044331,0.0001809925,0.002780955,0.00003456469,0.0004451038,0.000001407656,0.000525974,0.0001872983,0.8929523,0.00001836413,0.09844786,0.003981826],"study_design_scores_gemma":[0.0005493161,0.0001145497,0.000456251,0.00001472325,0.0002239267,0.000003861258,0.0004534991,0.0008384564,0.9426116,0.00002080281,0.05457958,0.0001334335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872383,0.000140863,0.0001870342,0.01162766,0.0001688762,0.0001474137,0.00008153611,0.00001380662,0.0003945281],"genre_scores_gemma":[0.9910507,0.0002270159,0.0005786414,0.007678371,0.0003426438,0.000007454417,0.000001868924,0.00002316297,0.00009016955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04965925,"threshold_uncertainty_score":0.6442238,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1938539934","doi":"10.1111/j.1479-8301.2012.00413.x","title":"Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine","year":2012,"lang":"en","type":"article","venue":"Psychogeriatrics","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":50,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institute of Aging","funders":"Tsumura and Company","keywords":"Dementia with Lewy bodies; Dementia; Psychiatry; Parkinsonism; Medicine; Adverse effect; Donepezil; Exacerbation; Internal medicine; Psychology; Disease","authors":[{"name":"Koh Iwasaki","is_ca":false},{"name":"Kenji Kosaka","is_ca":false},{"name":"Hideo Mori","is_ca":false},{"name":"Reina Okitsu","is_ca":false},{"name":"Katsutoshi Furukawa","is_ca":true},{"name":"Yuta Manabe","is_ca":false},{"name":"Mitsuhiro Yoshita","is_ca":false},{"name":"Aya Kanamori","is_ca":false},{"name":"N. Ito","is_ca":false},{"name":"Kenji Wada","is_ca":false},{"name":"Michio Kitayama","is_ca":false},{"name":"Jun Horiguchi","is_ca":false},{"name":"Shuhei Yamaguchi","is_ca":false},{"name":"Shin Takayama","is_ca":false},{"name":"Ryuji Fukuhara","is_ca":false},{"name":"Shinji Ouma","is_ca":false},{"name":"Seigo Nakano","is_ca":false},{"name":"Mamoru Hashimoto","is_ca":false},{"name":"Toru Kinoshita","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0693636639934578,"gpt":0.3702616414432984,"spread":0.3008979774498406,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006401401,0.00019979,0.0002818216,0.000315444,0.0001062728,0.000005118729,0.0001046399,0.0001596327,0.0006323681],"category_scores_gemma":[0.00003424258,0.0001552611,0.00002266755,0.0003380033,0.0001682638,0.0001996457,0.00002160497,0.000307942,0.000003187642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005982979,"about_ca_system_score_gemma":0.00006140523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005169853,"about_ca_topic_score_gemma":0.0004381014,"domain_scores_codex":[0.9985293,0.0001966761,0.0004653011,0.0002410127,0.0002163796,0.0003513391],"domain_scores_gemma":[0.9991108,0.0002931288,0.0002272115,0.0001093108,0.0001025093,0.0001570808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002849486,0.003352319,0.9782057,0.0001144208,0.0002143056,0.000005861383,0.004401116,0.000116245,0.004102658,0.001419449,0.0007519852,0.004466393],"study_design_scores_gemma":[0.007408222,0.001513023,0.9861146,0.00003622248,0.000314704,0.000007812328,0.0004654686,0.0002059723,0.0007717234,0.0001927523,0.002713248,0.0002562792],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960809,0.0007351637,0.00006871614,0.001032629,0.0003635604,0.0006024977,0.00008751795,0.00001342049,0.001015531],"genre_scores_gemma":[0.9986934,0.0002598534,0.0003333177,0.0003244591,0.000127642,0.000117316,0.00009376209,0.00001676264,0.00003346691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007908811,"threshold_uncertainty_score":0.6923987,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2052801348","doi":"10.1021/jo062350v","title":"Total Synthesis of (±)-Herbindole A, (±)-Herbindole B, and (±)-<i>cis</i>-Trikentrin A","year":2007,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":49,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; American Chemical Society Petroleum Research Fund","keywords":"Chemistry; Adduct; Total synthesis; Indole test; Tricyclic; Alkyl; Stereochemistry; Organic chemistry; Substitution (logic)","authors":[{"name":"Stephen K. Jackson","is_ca":true},{"name":"Michael A. Kerr","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03539766805058012,"gpt":0.3572887676741254,"spread":0.3218910996235453,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004099879,0.0002309839,0.0005358687,0.00008993281,0.0001082328,0.000008928066,0.0004740263,0.0003377075,0.004425044],"category_scores_gemma":[0.0003741432,0.0001737862,0.0001346432,0.0003092443,0.000348346,0.00009675709,0.0001271471,0.001072624,0.00001298211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000110541,"about_ca_system_score_gemma":0.000166226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001452972,"about_ca_topic_score_gemma":0.00001045996,"domain_scores_codex":[0.9979025,0.0003048089,0.0009464279,0.0001532986,0.0002458209,0.0004471588],"domain_scores_gemma":[0.9963999,0.00233353,0.0006994419,0.0001972921,0.0001423306,0.0002275038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001542714,0.0003612353,0.006078933,0.0001174817,0.0002210642,0.00009812643,0.000654107,0.00003587655,0.9827471,0.00001300981,0.0007492682,0.007381121],"study_design_scores_gemma":[0.001869112,0.00009039991,0.006261441,0.000062229,0.0003330133,0.001291897,0.0007968794,0.00003813594,0.9850871,0.0001366981,0.003853523,0.0001795464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923981,0.003665949,0.0001157482,0.0005827741,0.000340901,0.0001290093,0.00001014124,0.00001011246,0.002747216],"genre_scores_gemma":[0.9977708,0.001114791,0.00008076197,0.0002455706,0.0003567333,0.000001777073,5.695261e-7,0.00002781627,0.0004011836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007201575,"threshold_uncertainty_score":0.9964851,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2616751885","doi":"10.3390/ijms18051095","title":"Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades","year":2017,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":49,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Institute of Population and Public Health; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; King Saud University; National Research Foundation","keywords":"Cancer research; Protein kinase B; Signal transduction; Cell growth; Angiogenesis; Apoptosis; Biology; Annexin; Chemistry; Metastasis; Cancer; Medicine; Cell biology; Internal medicine; Biochemistry","authors":[{"name":"Hanwool Lee","is_ca":false},{"name":"Seung Woo Baek","is_ca":false},{"name":"Jong Eun Lee","is_ca":false},{"name":"Chulwon Kim","is_ca":false},{"name":"Jeong‐Hyeon Ko","is_ca":false},{"name":"Seok‐Geun Lee","is_ca":false},{"name":"Arunachalam Chinnathambi","is_ca":false},{"name":"Sulaiman Ali Alharbi","is_ca":false},{"name":"Woong Mo Yang","is_ca":false},{"name":"Jae‐Young Um","is_ca":false},{"name":"Gautam Sethi","is_ca":false},{"name":"Kwang Seok Ahn","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07960171795245023,"gpt":0.3848773789228022,"spread":0.305275660970352,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001392719,0.0001646948,0.0002993452,0.0002050793,0.0003856677,0.00009627841,0.0009987263,0.00009374618,0.00003004597],"category_scores_gemma":[0.0001157618,0.0001174724,0.0001250511,0.000085028,0.0006926343,0.000331598,0.0001570657,0.0004141921,0.000002007091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003793929,"about_ca_system_score_gemma":0.00009190313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002092458,"about_ca_topic_score_gemma":0.000007771318,"domain_scores_codex":[0.9980637,0.0004760762,0.0005473045,0.0002111209,0.000480159,0.0002215743],"domain_scores_gemma":[0.9981154,0.0005390046,0.000966429,0.0001143487,0.0001890084,0.00007579823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008203609,0.0004072094,0.02209265,0.00003117886,0.0001400593,0.0004703898,0.00158876,0.007012872,0.9666075,0.0005815625,0.00004681045,0.0009390173],"study_design_scores_gemma":[0.002845546,0.0002861129,0.01833723,0.00007110841,0.000164148,0.0001167346,0.0005321571,0.01243764,0.9620835,0.002765819,0.0001873144,0.0001727148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995974,0.001376329,0.0005606018,0.0006842767,0.001011192,0.0002056919,0.00001700986,0.000002926726,0.0001679881],"genre_scores_gemma":[0.9986686,0.0002556394,0.0005372705,0.0003932094,0.0001209082,0.000004147598,0.000001750953,0.000007982741,0.00001052492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005424763,"threshold_uncertainty_score":0.4790384,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2222434892","doi":"10.1385/mb:22:1:001","title":"Vindoline Biosynthesis Is Transcriptionally locked in Catharanthus roseus Cell Suspension Cultures","year":2002,"lang":"en","type":"article","venue":"Molecular Biotechnology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"Third World Academy of Sciences; Consejo Nacional de Ciencia y Tecnología","keywords":"Vindoline; Catharanthus roseus; Biology; Methyl jasmonate; Indole alkaloid; Aromatic L-amino acid decarboxylase; Biochemistry; Gene expression; Alkaloid; Apocynaceae; Jasmonate; Biosynthesis; Cell culture; Gene; Molecular biology; Botany; Enzyme; Indole test; Vinblastine; Genetics","authors":[{"name":"Felipe Vázquez‐Flota","is_ca":false},{"name":"Vincenzo De Luca","is_ca":true},{"name":"Mildred Carrillo-Pech","is_ca":false},{"name":"Adriana Canto‐Flick","is_ca":false},{"name":"María de Lourdes Miranda‐Ham","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05788364183435223,"gpt":0.3577433405141555,"spread":0.2998596986798033,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005078928,0.0005371967,0.0006672078,0.0006385538,0.0002397291,0.0000212743,0.0007746237,0.002086952,0.009065013],"category_scores_gemma":[0.0001017351,0.0005262844,0.0002800715,0.0007363196,0.0005962425,0.00008496388,0.000140467,0.001607924,0.0008264258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412281,"about_ca_system_score_gemma":0.0000416878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001059876,"about_ca_topic_score_gemma":0.00009778173,"domain_scores_codex":[0.9964959,0.0005969056,0.0007389126,0.0009046976,0.0002450502,0.001018526],"domain_scores_gemma":[0.9987787,0.0002124376,0.0002035715,0.0004995266,0.00008935118,0.000216416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002154142,0.001002991,0.0004975661,0.00004119009,0.0001212936,0.0006981165,0.0005246665,0.0001197391,0.9743503,0.001246594,0.0082505,0.01293161],"study_design_scores_gemma":[0.001986828,0.0001846168,0.0003882079,0.00001383367,0.0001362648,0.0001201696,0.00008056483,0.002325235,0.8132901,0.0004422893,0.1805473,0.0004846112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640199,0.008452498,0.0004720836,0.02151515,0.000789948,0.000722762,0.00009511863,0.0003308966,0.003601664],"genre_scores_gemma":[0.9872752,0.003312645,0.0005584335,0.007628897,0.0001000729,0.00009114746,0.00002914699,0.00006896922,0.0009354223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1722968,"threshold_uncertainty_score":0.9999515,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2011595304","doi":"10.1016/j.jep.2010.08.045","title":"Comparative effects of Rauwolfia vomitoria and chlorpromazine on locomotor behaviour and anxiety in mice","year":2010,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":47,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"Department of Foreign Affairs and Trade, Australian Government","keywords":"Motor coordination; Chlorpromazine; Open field; Reserpine; Anxiety; Motor activity; Internal medicine; Medicine; Pharmacology; Endocrinology; Psychology; Psychiatry","authors":[{"name":"Sunday Agba Bisong","is_ca":false},{"name":"Richard G. Brown","is_ca":true},{"name":"Eme Effiom Osim","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04802531348561474,"gpt":0.4257319735893695,"spread":0.3777066601037548,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00172578,0.0003793746,0.001149399,0.0004752586,0.0001279353,0.00001235622,0.000361066,0.0007031986,0.0004729247],"category_scores_gemma":[0.0002140162,0.0003317155,0.000137413,0.0002606402,0.0007422748,0.0001798737,0.0001335225,0.003006771,0.00001142488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005701173,"about_ca_system_score_gemma":0.0001540271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000273318,"about_ca_topic_score_gemma":0.00005202654,"domain_scores_codex":[0.9969616,0.0009574323,0.001013646,0.0003605821,0.0002068791,0.0004998464],"domain_scores_gemma":[0.9954699,0.002840966,0.0008921861,0.0001219355,0.0002618029,0.0004132289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002772792,0.001037219,0.04699685,0.0001361024,0.0003346935,0.0002162946,0.00161451,0.00003257124,0.9376307,0.0002975109,0.004430998,0.004499739],"study_design_scores_gemma":[0.01022104,0.001789236,0.1193373,0.00004989294,0.0006536603,0.0001980296,0.0001407735,0.000394765,0.8503866,0.0003807017,0.01608769,0.0003603141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887209,0.001572541,0.000006921615,0.0009672943,0.007586748,0.000616116,0.00002124285,0.00001405664,0.0004941638],"genre_scores_gemma":[0.9958614,0.001633083,0.0003668507,0.001113276,0.0008677038,0.00003368327,0.000001883407,0.00002850907,0.00009366916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08724415,"threshold_uncertainty_score":0.9999135,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2101368846","doi":"10.1139/v01-156","title":"Studies of palladium-catalyzed coupling reactions for preparation of hindered 3-arylpyrroles relevant to (-)-rhazinilam and its analogues","year":2001,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":46,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"Fédération Wallonie-Bruxelles","keywords":"Chemistry; Catalysis; Palladium; Combinatorial chemistry; Coupling reaction; Pyrrole; Substrate (aquarium); Coupling (piping); Organic chemistry","authors":[{"name":"Léon Ghosez","is_ca":false},{"name":"Cécile Franc","is_ca":false},{"name":"Frédéric Denonne","is_ca":false},{"name":"Claire Cuisinier","is_ca":false},{"name":"Roland Touillaux","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1393527016118583,"gpt":0.433277149158721,"spread":0.2939244475468626,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007431663,0.0001506682,0.0004562683,0.0001125464,0.0001552244,0.000007182855,0.0001814135,0.0002062531,0.0002211877],"category_scores_gemma":[0.0005853944,0.000146068,0.0001134997,0.0001371015,0.0001671625,0.0000894175,0.00001531523,0.0002706877,0.000001421288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009865059,"about_ca_system_score_gemma":0.0005799065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006195159,"about_ca_topic_score_gemma":0.0007384838,"domain_scores_codex":[0.9987385,0.00004835345,0.0007032412,0.0001516781,0.00008800426,0.0002702728],"domain_scores_gemma":[0.9977335,0.000545868,0.0005582969,0.00009277875,0.0005978843,0.0004716298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006322677,0.00005756002,0.003022075,0.0003115373,0.0006206335,0.00002741054,0.001489713,0.001516566,0.9880446,0.00004601336,0.003573164,0.0006584606],"study_design_scores_gemma":[0.00135602,0.000182495,0.001035791,0.0001321677,0.0003925894,0.0001788201,0.001288615,0.0008332608,0.958793,0.0003061305,0.03531542,0.000185688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909728,0.006811508,0.00005009729,0.001147829,0.000350989,0.0002064011,0.0001196911,0.000004593455,0.0003360799],"genre_scores_gemma":[0.9977081,0.001420888,0.0001463636,0.0001422742,0.000244913,0.00001264355,0.00001260753,0.00001440098,0.0002978289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03174226,"threshold_uncertainty_score":0.5956481,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4225522928","doi":"10.1080/00952990.2022.2041026","title":"Exploring the self-reported motivations of kratom (<i>Mitragyna speciosa</i> Korth.) use: a cross-sectional investigation","year":2022,"lang":"en","type":"article","venue":"The American Journal of Drug and Alcohol Abuse","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":46,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Medicine; Cannabis; Adverse effect; Demographics; Heroin; Anxiety; Self-medication; Mental health; Psychiatry; Depression (economics); Cross-sectional study; Traditional medicine; Drug; Pharmacology; Demography","authors":[{"name":"Oliver Grundmann","is_ca":false},{"name":"Charles A. Veltri","is_ca":false},{"name":"Diana Morcos","is_ca":false},{"name":"David Knightes","is_ca":false},{"name":"Kirsten E. Smith","is_ca":false},{"name":"Darshan Singh","is_ca":false},{"name":"Ornella Corazza","is_ca":false},{"name":"Eduardo Cinosi","is_ca":false},{"name":"Giovanni Martinotti","is_ca":false},{"name":"Zach Walsh","is_ca":true},{"name":"Marc T. Swogger","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2136311972873645,"gpt":0.3952840987500748,"spread":0.1816529014627103,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002253479,0.0001853746,0.0003484488,0.0001578457,0.0009598443,0.0000428867,0.000423657,0.00002706553,0.0004461999],"category_scores_gemma":[0.00007636027,0.0001224133,0.0001865966,0.0005683281,0.0008932396,0.00032702,0.0001045591,0.001181403,0.000004209347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007266633,"about_ca_system_score_gemma":0.000176015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007752492,"about_ca_topic_score_gemma":0.000005941797,"domain_scores_codex":[0.9970393,0.001325487,0.0008071199,0.00018595,0.0003632221,0.000278924],"domain_scores_gemma":[0.996227,0.001744871,0.001432227,0.0002018995,0.000236207,0.0001577811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00108822,0.0004856232,0.9247386,0.00001543473,0.002224199,0.00007443727,0.01754429,0.00821119,0.03721488,0.0008113845,0.002829004,0.004762699],"study_design_scores_gemma":[0.001369635,0.0003396358,0.9601845,0.000009153116,0.0005957828,0.0009660841,0.003467713,0.000455188,0.009348654,0.0003395064,0.02270108,0.0002230563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968601,0.000311717,0.0000211382,0.001398327,0.001024635,0.00021393,0.00004628624,0.00002350612,0.0001003536],"genre_scores_gemma":[0.9966013,0.0008320338,0.0001103143,0.001804139,0.0003932879,0.00004963112,0.000004658164,0.0000224065,0.0001822587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03544587,"threshold_uncertainty_score":0.7382444,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2941258199","doi":"10.1111/tpj.14346","title":"The assembly of (+)‐vincadifformine‐ and (−)‐tabersonine‐derived monoterpenoid indole alkaloids in <i>Catharanthus roseus</i> involves separate branch pathways","year":2019,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University","funders":"Université François-Rabelais; Brock University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Vindoline; Catharanthus roseus; Biosynthesis; Biology; Biochemistry; Metabolic pathway; Acetylation; Enantiomer; Stereochemistry; Enzyme; Chemistry; Gene","authors":[{"name":"D. R. Williams","is_ca":true},{"name":"Yang Qu","is_ca":true},{"name":"Razvan Simionescu","is_ca":true},{"name":"Vincenzo De Luca","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06304981231971415,"gpt":0.3391424195224029,"spread":0.2760926072026887,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003029726,0.0003458912,0.000557603,0.0001376704,0.0006266566,0.00007855902,0.0007597881,0.0003053889,0.0003362923],"category_scores_gemma":[0.00007343518,0.0002039152,0.000151598,0.0002152652,0.0004032635,0.0002183113,0.0001694222,0.001687003,0.00008209892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006419655,"about_ca_system_score_gemma":0.000191637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004939368,"about_ca_topic_score_gemma":0.0001003697,"domain_scores_codex":[0.9968365,0.001062897,0.0008046689,0.0002803885,0.0002638196,0.0007516718],"domain_scores_gemma":[0.9968594,0.002052285,0.0005444146,0.0002454909,0.00008255841,0.0002157945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002542123,0.0002725071,0.02225474,0.0000573395,0.0004111281,0.00007408518,0.005350222,0.0004615927,0.9510763,0.0008426479,0.005140081,0.01151722],"study_design_scores_gemma":[0.01342005,0.001174038,0.07062822,0.0002333796,0.0006012992,0.003517091,0.002213296,0.0177226,0.7521895,0.004815757,0.1322109,0.001273937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893534,0.005506418,0.0000181986,0.001339379,0.001406973,0.000517408,0.000158,0.00002867864,0.001671534],"genre_scores_gemma":[0.9910941,0.00678715,0.00002555256,0.001285216,0.0003086664,0.00002486339,0.00001301307,0.00003172089,0.0004297027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1988868,"threshold_uncertainty_score":0.831542,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3039863980","doi":"","title":"The Potential for Kratom as an Antidepressant and Antipsychotic.","year":2020,"lang":"en","type":"article","venue":"PubMed","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Antipsychotic; Antidepressant; Anxiolytic; Pharmacology; Opioid; Medicine; Anxiety; Psychiatry; Traditional medicine; Receptor; Schizophrenia (object-oriented programming); Internal medicine","authors":[{"name":"Lindsay E Johnson","is_ca":false},{"name":"Lilian Balyan","is_ca":false},{"name":"Amy Magdalany","is_ca":false},{"name":"Fizza Saeed","is_ca":false},{"name":"Robert Salinas","is_ca":false},{"name":"Starla Wallace","is_ca":false},{"name":"Charles A. Veltri","is_ca":false},{"name":"Marc T. Swogger","is_ca":false},{"name":"Zach Walsh","is_ca":true},{"name":"Oliver Grundmann","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.122403631001718,"gpt":0.3981881142030577,"spread":0.2757844832013397,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009069571,0.0002161766,0.0002549851,0.00003088409,0.0006882176,0.00008419435,0.0003769739,0.0002355761,0.0002407429],"category_scores_gemma":[0.0001755226,0.0001615246,0.0000997402,0.000110261,0.0003221444,0.0001483163,0.00007763338,0.0004196461,0.00004895135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001270849,"about_ca_system_score_gemma":0.0000340917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007091327,"about_ca_topic_score_gemma":0.000005395777,"domain_scores_codex":[0.9980111,0.000423457,0.0003161754,0.000443356,0.0001176194,0.0006883238],"domain_scores_gemma":[0.9984471,0.0006135983,0.0001253946,0.0001618119,0.00007486172,0.0005772638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008543137,0.00057761,0.01099558,0.0001298768,0.001109369,0.00009943993,0.00100603,0.0002420928,0.02053834,0.01079228,0.1271008,0.8188655],"study_design_scores_gemma":[0.00307689,0.0002068768,0.06125744,0.000001477298,0.0003709948,0.00004937102,0.0001806126,0.007479881,0.0174401,0.002780473,0.9067824,0.0003734946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687157,0.002680872,0.0003758335,0.02098531,0.001832307,0.00230569,0.00008195846,0.000147781,0.002874532],"genre_scores_gemma":[0.9827321,0.001053641,0.00007201551,0.01348195,0.0009671629,0.001215836,0.00001276055,0.00003505441,0.0004295458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.818492,"threshold_uncertainty_score":0.6586782,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2969901333","doi":"10.3390/antiox8090339","title":"Polyphenolic Composition and Antioxidant Activity of Uncaria tomentosa Commercial Bark Products","year":2019,"lang":"en","type":"article","venue":"Antioxidants","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Consejo Superior de Investigaciones Científicas; Fundación Costa Rica Estados Unidos para la Cooperación; Agencia Española de Cooperación Internacional para el Desarrollo; Universidad de Costa Rica","keywords":"Proanthocyanidin; Polyphenol; Oxygen radical absorbance capacity; Chemistry; Food science; Bark (sound); Antioxidant; Composition (language); Botany; Traditional medicine; Antioxidant capacity; Organic chemistry; Biology","authors":[{"name":"Mirtha Navarro-Hoyos","is_ca":false},{"name":"Elizabeth Arnáez-Serrano","is_ca":false},{"name":"Ileana Moreira","is_ca":false},{"name":"Alonso Hurtado","is_ca":true},{"name":"Daniela Monge","is_ca":false},{"name":"Marı́a Monagas","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06668485324207037,"gpt":0.3874976095549981,"spread":0.3208127563129277,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000723273,0.0003040634,0.0005742973,0.0001808237,0.0001990228,0.00001967197,0.0002492468,0.0003221757,0.001198166],"category_scores_gemma":[0.00003334878,0.0002959246,0.00009715583,0.0003099297,0.0003043462,0.0002513799,0.0001560423,0.0005232697,0.0002044258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004505922,"about_ca_system_score_gemma":0.00009061827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009916559,"about_ca_topic_score_gemma":0.0000104129,"domain_scores_codex":[0.9977108,0.0006249018,0.0004226407,0.0004978681,0.0002176241,0.0005261801],"domain_scores_gemma":[0.9987875,0.0003220906,0.0002858223,0.0002890528,0.0001377864,0.0001777464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006812362,0.0006307946,0.07821574,0.0001573196,0.0002406507,0.00001058177,0.0003543396,0.00001291279,0.9038343,0.001332721,0.00123595,0.01329349],"study_design_scores_gemma":[0.001986313,0.0002238905,0.4623632,0.00003573427,0.0001828844,0.0000394885,0.00004112206,0.0003435828,0.5260835,0.0001169231,0.008269631,0.0003136955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924727,0.0005188049,0.00003134238,0.0007269723,0.00144105,0.0007254696,0.0001007745,0.00006748294,0.003915394],"genre_scores_gemma":[0.9978869,0.0004880588,0.0001254809,0.0007819268,0.0002320068,0.00001860156,0.00001169358,0.00003177742,0.0004235407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3841474,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3201366177","doi":"10.1038/s42003-021-02617-w","title":"Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":43,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; National Key Research and Development Program of China; Brock University; Tsinghua University; Shanghai Jiao Tong University; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Vindoline; Metabolic engineering; Biochemistry; Vinblastine; Saccharomyces cerevisiae; Yeast; Chemistry; Indole alkaloid; Biology; Enzyme; Indole test; Genetics","authors":[{"name":"Tengfei Liu","is_ca":false},{"name":"Ying Huang","is_ca":false},{"name":"Lihong Jiang","is_ca":false},{"name":"Chang Dong","is_ca":false},{"name":"Yuanwei Gou","is_ca":false},{"name":"Jiazhang Lian","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1003149926864002,"gpt":0.4230541143150455,"spread":0.3227391216286452,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006393243,0.0002418993,0.0005846067,0.0001053241,0.0002643184,0.000008079538,0.000916875,0.0004128941,0.003169],"category_scores_gemma":[0.0004986062,0.0002325671,0.0001518716,0.0004285984,0.0006112729,0.00003173252,0.0004379459,0.0007189341,0.0001070242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004711326,"about_ca_system_score_gemma":0.0001388983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008422027,"about_ca_topic_score_gemma":0.00003967095,"domain_scores_codex":[0.9968525,0.00161927,0.0006632713,0.0004280636,0.00007833642,0.0003585996],"domain_scores_gemma":[0.9967814,0.001234105,0.0003073245,0.001180122,0.0003490619,0.0001480004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001073217,0.00105286,0.002974503,0.00001900412,0.0005116597,0.000001559391,0.0003338939,0.000314782,0.9613842,0.004953368,0.01313056,0.01521624],"study_design_scores_gemma":[0.001003639,0.00006696431,0.001989021,0.00001438486,0.000399556,0.00001753438,0.000130447,0.004672275,0.3795573,0.0005162706,0.6113524,0.0002802162],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9214136,0.05431812,0.0007179429,0.01776652,0.001855006,0.0004789462,0.0007254434,0.0001334049,0.002590994],"genre_scores_gemma":[0.9879539,0.005020704,0.004028622,0.0009912913,0.0002237479,0.0001111651,0.001036459,0.00002520147,0.000608901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5982218,"threshold_uncertainty_score":0.9977422,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4388978139","doi":"10.1038/s42003-023-05574-8","title":"The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids","year":2023,"lang":"en","type":"article","venue":"Communications Biology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":43,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Novo Nordisk Fonden; Agence Nationale de la Recherche; European Commission","keywords":"Monoterpene; Indole test; Botany; Biology; Chemistry; Stereochemistry","authors":[{"name":"Emily Amor Stander","is_ca":false},{"name":"Beata Joanna Lehka","is_ca":false},{"name":"Inês Carqueijeiro","is_ca":false},{"name":"Clément Cuello","is_ca":false},{"name":"Frederik G. Hansson","is_ca":false},{"name":"Hans J. Jansen","is_ca":false},{"name":"Thomas Dugé de Bernonville","is_ca":false},{"name":"Caroline Birer-Williams","is_ca":false},{"name":"Valentin Vergès","is_ca":false},{"name":"Enzo Lezin","is_ca":false},{"name":"Marcus Daniel Brandbjerg Bohn Lorensen","is_ca":false},{"name":"Thu‐Thuy T. Dang","is_ca":true},{"name":"Audrey Oudin","is_ca":false},{"name":"Arnaud Lanoue","is_ca":false},{"name":"Mickaël Durand","is_ca":false},{"name":"Nathalie Giglioli‐Guivarc’h","is_ca":false},{"name":"Christian Janfelt","is_ca":false},{"name":"Nicolas Papon","is_ca":false},{"name":"Ron P. Dirks","is_ca":false},{"name":"Sarah E. O’Connor","is_ca":false},{"name":"Michael K. Jensen","is_ca":false},{"name":"Sébastien Besseau","is_ca":false},{"name":"Vincent Courdavault","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1642312557187163,"gpt":0.4474681205666093,"spread":0.2832368648478931,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.002069171,0.0003828061,0.000496524,0.0002613394,0.002348182,0.0000504169,0.002696529,0.0005800136,0.0002590857],"category_scores_gemma":[0.000954927,0.0002997295,0.0002882031,0.000693209,0.0016398,0.00007220609,0.000835245,0.0008352096,0.0006153695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009498659,"about_ca_system_score_gemma":0.0001271942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005488639,"about_ca_topic_score_gemma":0.0003822522,"domain_scores_codex":[0.9960515,0.001627039,0.0007392883,0.0005191346,0.00008503156,0.0009779724],"domain_scores_gemma":[0.9845262,0.01316095,0.0003032844,0.001569334,0.0002104246,0.0002297561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001347105,0.001311211,0.1029196,0.0001046785,0.001716351,0.00001040789,0.001908699,0.0002848082,0.6278546,0.03192449,0.02691484,0.2037032],"study_design_scores_gemma":[0.001660771,0.0002425112,0.0227098,0.000008757321,0.0001936643,0.00001865476,0.0002317909,0.008763852,0.01051862,0.004574149,0.9506246,0.0004528135],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9326715,0.01714505,0.001395976,0.03288729,0.003714921,0.003650751,0.001838147,0.001077667,0.005618683],"genre_scores_gemma":[0.988049,0.00656139,0.0006873021,0.001022311,0.0002853107,0.001382951,0.0008497254,0.00006359715,0.001098439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9237098,"threshold_uncertainty_score":0.9999455,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4390751159","doi":"10.1038/s41467-024-44797-z","title":"De novo biosynthesis of antiarrhythmic alkaloid ajmaline","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":43,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of New Brunswick","funders":"Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; New Brunswick Innovation Foundation; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Government of Canada","keywords":"Ajmaline; Biosynthesis; Alkaloid; Apocynaceae; Biochemistry; Vinblastine; Biology; Pharmacology; Enzyme; Chemistry; Stereochemistry; Botany; Genetics; Neuroscience","authors":[{"name":"Jun Guo","is_ca":true},{"name":"Di Gao","is_ca":false},{"name":"Jiazhang Lian","is_ca":false},{"name":"Yang Qu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09235691073817975,"gpt":0.4625742790755268,"spread":0.3702173683373471,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001173876,0.0002277536,0.0003253267,0.0002751946,0.0002955969,0.00003041969,0.001227616,0.0009114869,0.002151317],"category_scores_gemma":[0.0002789923,0.0002141419,0.0002173667,0.0005921336,0.0005044939,0.0001190346,0.0003104318,0.002389459,0.0002189473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009316109,"about_ca_system_score_gemma":0.000246511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001936446,"about_ca_topic_score_gemma":0.0000659471,"domain_scores_codex":[0.9978895,0.0008247936,0.0004708042,0.0002873148,0.0001330874,0.000394546],"domain_scores_gemma":[0.9959318,0.002660187,0.0001197681,0.0009714221,0.0001521177,0.0001646794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002026639,0.0008385621,0.005532051,0.0002475443,0.001167207,0.00006872548,0.001292182,0.0001242343,0.7457798,0.1230166,0.05654063,0.06518982],"study_design_scores_gemma":[0.0002953655,0.00004460819,0.001595512,0.00005276568,0.0003765382,0.0001312317,0.00006849122,0.005748701,0.106222,0.0009238715,0.8843036,0.0002372729],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6501809,0.2227481,0.0007900679,0.05510083,0.004231708,0.001187659,0.001060736,0.0008924982,0.06380743],"genre_scores_gemma":[0.9859591,0.007983855,0.002545478,0.002347606,0.000288749,0.00007509413,0.00006787316,0.00004363342,0.0006885898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.827763,"threshold_uncertainty_score":0.9999121,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2944823589","doi":"10.1177/0269881119844186","title":"Mitragynine (Kratom) impairs spatial learning and hippocampal synaptic transmission in rats","year":2019,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":43,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"","keywords":"Hippocampal formation; Neuroscience; Neurotransmission; Spatial learning; Psychology; Hippocampus; Transmission (telecommunications); Medicine; Computer science; Internal medicine; Receptor","authors":[{"name":"Zurina Hassan","is_ca":false},{"name":"Farah Wahida Suhaimi","is_ca":false},{"name":"Surash Ramanathan","is_ca":false},{"name":"King‐Hwa Ling","is_ca":false},{"name":"Mohamad Azmeer Effendy","is_ca":false},{"name":"Christian P. Müller","is_ca":false},{"name":"Hans C. Dringenberg","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03257449750547366,"gpt":0.4017084917431061,"spread":0.3691339942376324,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002468696,0.0004425626,0.001001403,0.0006787825,0.0001514455,0.00002407436,0.0004249849,0.000687453,0.0144379],"category_scores_gemma":[0.00007958474,0.0003958344,0.0002693774,0.000384722,0.0002734555,0.0002645364,0.00007140964,0.00311018,0.0002207416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506684,"about_ca_system_score_gemma":0.0002387962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002195361,"about_ca_topic_score_gemma":0.00001114747,"domain_scores_codex":[0.9952106,0.001883449,0.001338228,0.0004647665,0.0002823926,0.0008205489],"domain_scores_gemma":[0.9970271,0.001333461,0.0007818718,0.0001153665,0.0001878938,0.0005543249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008636962,0.0009465221,0.09575085,0.0001666076,0.0008228321,0.0007012548,0.001205027,0.001527556,0.8147389,0.00006855913,0.005652371,0.06978257],"study_design_scores_gemma":[0.05469024,0.007838053,0.08735835,0.0002620773,0.001882638,0.003762168,0.001249311,0.0196105,0.08503842,0.001718028,0.734634,0.001956183],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849039,0.006058904,0.0001908945,0.001622314,0.004644876,0.0005371828,0.00000631057,0.00003682477,0.001998743],"genre_scores_gemma":[0.9920225,0.004369986,0.0003632191,0.001963084,0.0007141016,0.00001867399,0.000003895246,0.00005550698,0.0004890379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7297005,"threshold_uncertainty_score":0.9998494,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4385406638","doi":"10.1111/nph.19162","title":"Biosynthesis of kratom opioids","year":2023,"lang":"en","type":"article","venue":"New Phytologist","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of New Brunswick; Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation","keywords":"Indole alkaloid; Tryptamine; Biosynthesis; Opium Poppy; O-methyltransferase; Biology; Biochemistry; Chemistry; Methyltransferase; Enzyme; Indole test; Gene; Botany; Papaver; Methylation","authors":[{"name":"Kyung‐Hee Kim","is_ca":true},{"name":"Mohammadamin Shahsavarani","is_ca":true},{"name":"Jorge Jonathan Oswaldo Garza‐García","is_ca":true},{"name":"Jack Edward Carlisle","is_ca":true},{"name":"Guo Jun","is_ca":true},{"name":"Vincenzo De Luca","is_ca":true},{"name":"Yang Qu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.163288845894473,"gpt":0.4424779176105156,"spread":0.2791890717160426,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000806771,0.0003042536,0.0005756106,0.0002750233,0.0002058228,0.00001232119,0.0005954441,0.0005341708,0.007471045],"category_scores_gemma":[0.0002782263,0.0002791565,0.0002354663,0.0008408976,0.0005615587,0.00009139394,0.0001726971,0.000563625,0.002665167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000451977,"about_ca_system_score_gemma":0.0002128099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122209,"about_ca_topic_score_gemma":0.00003858798,"domain_scores_codex":[0.9976156,0.0004613124,0.0005635505,0.0004586442,0.0001950302,0.0007059117],"domain_scores_gemma":[0.9977368,0.001252793,0.0002547842,0.0003553556,0.00008507965,0.0003151911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000546022,0.0003714682,0.05572375,0.0001236051,0.000477216,0.0001260245,0.0004773333,0.0003268201,0.3688614,0.005767873,0.4872122,0.0799863],"study_design_scores_gemma":[0.001189533,0.0001721546,0.01960128,0.00001484211,0.0001907578,0.0000195692,0.000138674,0.0007035646,0.3955844,0.002374053,0.5796517,0.0003595535],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398396,0.001286515,0.000154958,0.00508898,0.003534849,0.0005246071,0.0001749712,0.0007060034,0.0486895],"genre_scores_gemma":[0.9909477,0.0008576251,0.0002394718,0.001475581,0.0005647443,0.00004401307,0.00003232763,0.00004042161,0.005798106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09243947,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4281915367","doi":"10.1038/s41467-022-31100-1","title":"A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Brock University; University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Canada Foundation for Innovation; Universiti Malaya; Government of Canada; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Catharanthus roseus; Biosynthesis; Redox; Stereochemistry; Dioxygenase; ATP synthase; Chemistry; Biochemistry; Vinblastine; Enzyme; Biology; Organic chemistry","authors":[{"name":"Jasmine Ga May Eng","is_ca":true},{"name":"Mohammadamin Shahsavarani","is_ca":true},{"name":"Daniel Patrick Smith","is_ca":true},{"name":"Josef Hájíček","is_ca":false},{"name":"Vincenzo De Luca","is_ca":true},{"name":"Yang Qu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1023531724664069,"gpt":0.4334574996592935,"spread":0.3311043271928866,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00259685,0.000428084,0.0005502816,0.0004372114,0.004299334,0.000037682,0.002196281,0.000748372,0.0008248076],"category_scores_gemma":[0.0005732392,0.0004123634,0.0003595055,0.0006930656,0.0003748323,0.0002024015,0.001133484,0.003824871,0.00006991217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004621159,"about_ca_system_score_gemma":0.0005319941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000141718,"about_ca_topic_score_gemma":0.0007092291,"domain_scores_codex":[0.9953374,0.002205095,0.00076371,0.0006610852,0.0002765919,0.0007560932],"domain_scores_gemma":[0.9940016,0.003271698,0.0004517666,0.001707358,0.0002700262,0.0002975196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005076788,0.003296193,0.0006590525,0.00004987072,0.0008135291,0.00003319939,0.002606235,0.0006705064,0.8996273,0.009156618,0.06537176,0.01263891],"study_design_scores_gemma":[0.002023892,0.0003706861,0.001010235,0.000008399108,0.0004822697,0.0001397464,0.0005122767,0.002202565,0.1760921,0.0005854376,0.8160581,0.0005143405],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9221637,0.01911833,0.00006237026,0.04216337,0.004098927,0.003079205,0.004675888,0.0005835359,0.00405471],"genre_scores_gemma":[0.9866893,0.001900049,0.001287241,0.003398568,0.0003397733,0.002371263,0.0008209721,0.00008959081,0.003103185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7506863,"threshold_uncertainty_score":0.9998328,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2952787604","doi":"10.1021/jo010751z","title":"Asymmetric Synthesis of (−)-Eburnamonine and (+)-<i>e</i><i>pi</i>-Eburnamonine from (4<i>S</i>)-4-Ethyl-4-[2-(hydroxycarbonyl)ethyl]-2-butyrolactone","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Regina","funders":"","keywords":"Aldehyde; Chemistry; Lactam; Amide; Stereospecificity; Tryptamine; Stereochemistry; Catalysis; Organic chemistry","authors":[{"name":"Andrew G. H. Wee","is_ca":true},{"name":"Qing Yu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03439579493116394,"gpt":0.335944347309622,"spread":0.301548552378458,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002683201,0.0005217391,0.001114901,0.0001661441,0.0002833955,0.00002778833,0.001130024,0.0006138405,0.00642749],"category_scores_gemma":[0.0009134277,0.0003906137,0.0002956139,0.0008003343,0.0006628262,0.0001947753,0.0002798766,0.002098083,0.00002416547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001434162,"about_ca_system_score_gemma":0.0002459106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006717678,"about_ca_topic_score_gemma":0.00000926928,"domain_scores_codex":[0.9962599,0.0007643359,0.001463335,0.0003330303,0.0005275324,0.0006519077],"domain_scores_gemma":[0.9929554,0.004037744,0.001649543,0.0004865993,0.0003667614,0.0005039736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001569912,0.0005152655,0.01207819,0.00007736729,0.001076444,0.0001579977,0.0004492573,0.00005502879,0.9701346,0.000005320943,0.003175561,0.01070511],"study_design_scores_gemma":[0.002576069,0.0002253973,0.00372002,0.00009102991,0.001934035,0.001338342,0.0003524198,0.0002904317,0.9643461,0.0004794394,0.02423153,0.0004152518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713877,0.02008468,0.0001467475,0.002800224,0.0006415624,0.0001869432,0.00006320325,0.00003657583,0.004652372],"genre_scores_gemma":[0.9752137,0.02202588,0.0002061567,0.0008209079,0.001023498,0.000006158535,0.000005762758,0.00007749107,0.0006204498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02105597,"threshold_uncertainty_score":0.9998546,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}