{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":614,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":614,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"query_hash":"69628958488d","filters":{"topic":"Barrier Structure and Function Studies"}},"results":[{"id":"W2125411036","doi":"10.1101/cshperspect.a020412","title":"The Blood–Brain Barrier","year":2015,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Biology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":3282,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Biology; Neuroscience; Cognitive science; Environmental ethics; Library science; Psychology; Computer science; Philosophy","retraction":null,"screen_n_in":null,"score":{"opus":0.07092032220162008,"gpt":0.3591032169868933,"spread":0.2881828947852733,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005647884,0.0004445862,0.001125792,0.0002184145,0.0003716112,0.00006811409,0.000743345,0.000361234,0.00002741903],"category_scores_gemma":[0.002871016,0.0002776786,0.0002749574,0.0005553302,0.0008755559,0.00005425592,0.0003835856,0.0008526694,0.00006813515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338642,"about_ca_system_score_gemma":0.000271604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001651334,"about_ca_topic_score_gemma":0.00001451616,"domain_scores_codex":[0.9971889,0.0006901129,0.000466996,0.000958953,0.0001449259,0.0005501604],"domain_scores_gemma":[0.9974887,0.001412968,0.0002520397,0.0006669229,0.00007333038,0.0001060532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002413573,0.0000599746,0.00005770886,0.0004885785,0.0001844929,0.00005925709,0.0006782073,3.418328e-7,0.0008891055,0.939438,0.001231641,0.05688848],"study_design_scores_gemma":[0.0001889394,0.00006937447,0.00001824978,0.0002548551,0.00009575266,0.00000717769,0.0001199823,7.923528e-7,0.00006593548,0.0004264841,0.9984469,0.0003055042],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003605476,0.9943722,0.00001361439,0.0001921645,0.001558413,0.0005681391,0.00004241027,0.00009253219,0.003124483],"genre_scores_gemma":[0.0008272549,0.9975269,0.00003275592,0.0001267179,0.000494183,0.0002315097,3.295722e-7,0.0000469155,0.0007133647],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9972153,"threshold_uncertainty_score":0.9999675,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2107798346","doi":"10.1096/fj.04-3458fje","title":"Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line","year":2005,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":1340,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Open Society Foundations; Université Paris Descartes; Institut National de la Santé et de la Recherche Médicale; Leverhulme Trust; Multiple Sclerosis Society of Canada; Sidaction; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Multiple Sclerosis Society; Wellcome Trust; Centre National de la Recherche Scientifique; Wellcome","keywords":"Blood–brain barrier; Endothelium; Cell biology; CD31; Endothelial stem cell; Biology; Chemokine; Cell culture; Immunology; Angiogenesis; Cancer research; Inflammation; Neuroscience; Central nervous system; In vitro; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.03267748413557786,"gpt":0.2415294501440604,"spread":0.2088519660084826,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003820342,0.0001902373,0.0002383311,0.0001017316,0.0008119116,0.00009078658,0.0004275944,0.00005334249,0.00035295],"category_scores_gemma":[0.0003201805,0.0001093599,0.0001613708,0.0001814994,0.0003841624,0.0001728563,0.00008745679,0.0005055367,0.00004159746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002051416,"about_ca_system_score_gemma":0.00005262305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007823035,"about_ca_topic_score_gemma":0.00001443162,"domain_scores_codex":[0.9983378,0.0002538705,0.0004408865,0.0002162757,0.0004285498,0.0003226313],"domain_scores_gemma":[0.9990799,0.0001514271,0.0002588626,0.0002769503,0.0001167229,0.0001161028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009073363,0.00005198481,0.00007024186,0.000009222937,0.00001556555,0.00001165151,0.003114876,0.00003242824,0.9894787,0.0005985262,0.005325614,0.001200449],"study_design_scores_gemma":[0.001064312,0.0002466775,0.00007015534,0.00002878813,0.00002760932,0.0003066169,0.0005385549,0.00002976657,0.9848243,0.0003482817,0.01238097,0.0001339543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898336,0.0006365298,0.0001321375,0.005309846,0.0004711222,0.0001481937,0.00003256129,0.00003901936,0.00339702],"genre_scores_gemma":[0.9901659,0.0001427067,0.00007383827,0.003136326,0.001474811,0.000005449866,3.087969e-7,0.00002149499,0.004979108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007055361,"threshold_uncertainty_score":0.624465,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2159745814","doi":"10.1136/gut.2005.085373","title":"Alterations in intestinal permeability","year":2006,"lang":"en","type":"review","venue":"Gut","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":633,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Barrier function; Tight junction; Context (archaeology); Intestinal permeability; Biology; Inflammation; Gastrointestinal tract; Immunology; Cell biology; Pathology; Medicine; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.1158142809572249,"gpt":0.3636490919501528,"spread":0.247834810992928,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008022918,0.0001868782,0.000544006,0.0001086371,0.0001050946,0.00003744242,0.0001470439,0.00008381621,0.00006909353],"category_scores_gemma":[0.0004858331,0.0001401464,0.0001438782,0.0003525701,0.00009803054,0.0000530634,0.00006842143,0.0003174467,0.000141084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006140834,"about_ca_system_score_gemma":0.00008963385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000313587,"about_ca_topic_score_gemma":0.00007009403,"domain_scores_codex":[0.9988438,0.0001414576,0.0003459867,0.0003890125,0.0001150918,0.0001646146],"domain_scores_gemma":[0.9993697,0.0002486682,0.00009203691,0.0002458127,0.00001689491,0.00002690041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001573896,0.0000286475,0.00004524991,0.00165042,0.000003196898,0.00001876256,0.00005573739,0.000001336482,0.000007134069,0.001637558,0.003836671,0.9927137],"study_design_scores_gemma":[0.0000350398,0.00001097459,0.00007833984,0.000479029,0.00003299545,0.00004783008,0.000002575866,0.000002736953,0.000002760454,0.0003292551,0.9988527,0.0001258044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009973949,0.9778119,0.00008873756,0.00002857096,0.0005675995,0.0002881146,0.00003917402,0.00005092602,0.02111495],"genre_scores_gemma":[0.0002144203,0.9977356,0.0000721734,0.0001051779,0.0002310526,0.00009678221,0.00001236801,0.00001391709,0.001518535],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.995016,"threshold_uncertainty_score":0.5715004,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2080938528","doi":"10.1038/nrn2995","title":"Engaging neuroscience to advance translational research in brain barrier biology","year":2011,"lang":"en","type":"review","venue":"Nature reviews. Neuroscience","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":586,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Blood–brain barrier; Neuroscience; Disease; Medicine; Cerebrospinal fluid; Brain disease; Psychology; Central nervous system; Pathology","retraction":null,"screen_n_in":null,"score":{"opus":0.2823532348230848,"gpt":0.4870582295553426,"spread":0.2047049947322578,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004423435,0.001028362,0.002581561,0.001981395,0.001121382,0.0002121656,0.003405937,0.0007838022,0.0000549174],"category_scores_gemma":[0.01511951,0.0007765196,0.0005866803,0.01080554,0.001480519,0.0006646994,0.0008099282,0.006428203,0.0002243045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489713,"about_ca_system_score_gemma":0.0007142598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008313088,"about_ca_topic_score_gemma":0.00001941416,"domain_scores_codex":[0.9873713,0.004107976,0.001657983,0.003889976,0.001138741,0.00183405],"domain_scores_gemma":[0.9951516,0.00208699,0.0005268462,0.001510139,0.0001585572,0.0005658583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001025218,0.00004686955,0.00002232954,0.001856555,8.549796e-7,0.00005267119,0.0001865074,0.00000191459,0.001867548,0.01071106,0.001623831,0.9836196],"study_design_scores_gemma":[0.000117923,0.0001375602,0.00006079329,0.003051161,0.00002611399,0.0001881184,0.000004761235,0.000008402555,0.00006792332,0.0009619432,0.9946972,0.0006780695],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004822015,0.9872938,0.0005984462,0.0005827532,0.004843523,0.002963438,0.0001402334,0.0001140939,0.003458888],"genre_scores_gemma":[0.0004588627,0.9880696,0.0003163604,0.009433036,0.0003403698,0.0005906441,0.000004717351,0.00008454351,0.0007018437],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9930734,"threshold_uncertainty_score":0.9994686,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1995195889","doi":"10.1111/j.1471-4159.2008.05492.x","title":"Involvement of the low‐density lipoprotein receptor‐related protein in the transcytosis of the brain delivery vector Angiopep‐2","year":2008,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":551,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Montréal; Angiochem (Canada)","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"Transcytosis; LRP1; Blood–brain barrier; Biology; Endocytic cycle; Receptor; Lactoferrin; LDL receptor; Cell biology; Biochemistry; Lipoprotein; Endocrinology; Central nervous system; Endocytosis; Cholesterol","retraction":null,"screen_n_in":null,"score":{"opus":0.01981845277435594,"gpt":0.2102484323079038,"spread":0.1904299795335479,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905906,0.0001472192,0.0002607423,0.0000344438,0.0001887311,0.000009190153,0.0007206449,0.00007996696,0.00002622087],"category_scores_gemma":[0.0006584902,0.00007274678,0.0003095007,0.000559458,0.000367861,0.00007669039,0.00008881478,0.0005877683,5.684537e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003005157,"about_ca_system_score_gemma":0.0001181243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001888191,"about_ca_topic_score_gemma":0.000006207238,"domain_scores_codex":[0.9981611,0.0002804064,0.0005928754,0.0001653106,0.0006425926,0.00015768],"domain_scores_gemma":[0.9986448,0.0001740646,0.0006431909,0.0003702634,0.0001328397,0.00003489821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009930304,0.00009036699,0.001223512,0.00004993446,0.00001668186,0.00001190044,0.001439352,0.0000174317,0.9958341,0.00001005223,0.00105847,0.0001488726],"study_design_scores_gemma":[0.0005074271,0.00008291526,0.04678322,0.0001223099,0.00002048808,0.0001682277,0.0002509998,0.000004208742,0.9513263,0.00006619051,0.0006015887,0.00006610506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995891,0.0001323055,0.000005351129,0.003217178,0.0002640683,0.0002612574,0.00000995445,0.000004195526,0.0002147385],"genre_scores_gemma":[0.9989585,0.000052709,0.00001425738,0.0007152462,0.00007280971,0.000005448288,1.100576e-7,0.000009229131,0.000171707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0455597,"threshold_uncertainty_score":0.2966527,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2078412655","doi":"10.1093/brain/awl317","title":"TGF-  receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis","year":2006,"lang":"en","type":"article","venue":"Brain","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":547,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"German-Israeli Foundation for Scientific Research and Development","keywords":"Epileptogenesis; Extracellular; Blood–brain barrier; Albumin; Receptor; Neuroscience; Astrocyte; Chemistry; Epilepsy; Internal medicine; Central nervous system; Biology; Medicine; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01946989926664465,"gpt":0.2465558128760172,"spread":0.2270859136093726,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545847,0.0002161372,0.0002721255,0.0001638214,0.000155015,0.00004828902,0.0001957859,0.0001261729,0.0004594715],"category_scores_gemma":[0.0008586941,0.0001949085,0.00008408222,0.0006709048,0.0002068836,0.0001404454,0.00009681401,0.0001885837,0.0003218021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000581421,"about_ca_system_score_gemma":0.00004909434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002374095,"about_ca_topic_score_gemma":0.0004501117,"domain_scores_codex":[0.9982384,0.0001266257,0.0004086184,0.0005310986,0.0002897847,0.0004054955],"domain_scores_gemma":[0.9990892,0.0004548718,0.00007907755,0.0002502586,0.00003389753,0.00009274214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001484701,0.000103181,0.04692631,0.00001948091,0.00001023787,0.00002764001,0.0008368859,0.00001171113,0.8155692,0.002495616,0.1248151,0.009036165],"study_design_scores_gemma":[0.00146762,0.0001405325,0.1299239,0.00002382356,0.00001125997,0.000006996268,0.0003889001,0.0002182459,0.5214996,0.001881178,0.3439654,0.0004725374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921054,0.0001855014,0.0003663268,0.004051776,0.0005290543,0.0002385536,0.0000299823,0.0001459791,0.002347375],"genre_scores_gemma":[0.9929307,0.00002208744,0.0006260786,0.004803996,0.0002754779,0.00005284768,0.00001358928,0.00002518537,0.001250108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2940696,"threshold_uncertainty_score":0.7948136,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1506045573","doi":"10.1002/glia.22575","title":"Glial influence on the blood brain barrier","year":2013,"lang":"en","type":"review","venue":"Glia","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":534,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"Blood–brain barrier; Biology; Central nervous system; Neuroscience; Homeostasis; Astrocyte; Phenotype; Endothelium; Neuroglia; Cell biology; Inflammation; Microglia; Endothelial stem cell; Immunology; In vitro; Endocrinology; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.07244220120256166,"gpt":0.314751050197452,"spread":0.2423088489948904,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001473101,0.0004202234,0.0007511663,0.00007984594,0.0004112482,0.0001431666,0.0006715853,0.000212584,0.0007145893],"category_scores_gemma":[0.001874441,0.0002160988,0.0003236418,0.000373579,0.0002558247,0.00008910452,0.0001874045,0.0006568815,0.002267645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002135219,"about_ca_system_score_gemma":0.000100937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000991176,"about_ca_topic_score_gemma":0.000001731679,"domain_scores_codex":[0.9980257,0.0002943844,0.0003734762,0.0005928239,0.0003684546,0.0003451578],"domain_scores_gemma":[0.9979136,0.0009838034,0.0002296725,0.0007398145,0.00003944549,0.00009368062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007167404,0.00003064771,0.000003942199,0.001779638,0.0001187809,0.00004396707,0.0002229972,6.150096e-7,0.0002470329,0.02343062,0.1305874,0.8435272],"study_design_scores_gemma":[0.00006880468,0.00005042464,0.000004362615,0.0007008687,0.0001727704,0.00003503454,0.000005695955,2.427003e-7,0.0001767085,0.0003586268,0.9981833,0.0002431781],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000150042,0.9842908,0.000003459615,0.0004052733,0.001732061,0.0009072371,0.0001201403,0.0001127012,0.01227824],"genre_scores_gemma":[0.00008724017,0.9859939,0.000007925323,0.004324926,0.000540616,0.0002703881,0.000002028195,0.00003865777,0.008734372],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8675959,"threshold_uncertainty_score":0.9985092,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2042652697","doi":"10.1074/jbc.m905251199","title":"Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":484,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"University of Alberta; Consiglio Nazionale delle Ricerche; Yale University","keywords":"Occludin; Tight junction; Cell biology; PDZ domain; Cytoplasm; Chinese hamster ovary cell; Colocalization; Immunoprecipitation; Cell adhesion molecule; Chemistry; Cell junction; Biology; Biochemistry; Receptor; Cell","retraction":null,"screen_n_in":null,"score":{"opus":0.03662811956621109,"gpt":0.2543790462744714,"spread":0.2177509267082603,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159478,0.00009455925,0.00016226,0.00001606813,0.0001247214,0.00001434862,0.00008404384,0.00006740821,0.0003585476],"category_scores_gemma":[0.00009081627,0.00004471485,0.00005893954,0.0001047348,0.0001982119,0.00007332066,0.00002227425,0.0002466691,0.000001768371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001714629,"about_ca_system_score_gemma":0.00001164891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000159164,"about_ca_topic_score_gemma":1.76912e-7,"domain_scores_codex":[0.9993085,0.00004978252,0.0002351658,0.0001322176,0.0001884253,0.00008588058],"domain_scores_gemma":[0.9994626,0.0001088791,0.0002414246,0.00006638266,0.00007467504,0.00004601954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006042802,0.00004115066,0.001119399,0.00000897283,0.0000167561,0.00000798065,0.00003262461,0.00002227392,0.9952059,0.00001110945,0.0007464703,0.002183027],"study_design_scores_gemma":[0.0005972768,0.0003380705,0.02131476,0.00003599088,0.00002911007,0.0007529233,0.0001923198,0.00003841611,0.9652056,0.0001690129,0.01123791,0.00008860932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996943,0.0001232912,0.0001268496,0.0004965778,0.0001295241,0.00003132924,0.000003005793,0.000007504332,0.002138935],"genre_scores_gemma":[0.9991167,0.0001944489,0.00005099065,0.0002518812,0.0001744206,0.000001024199,0.000001066468,0.000003093311,0.0002064009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03000036,"threshold_uncertainty_score":0.3925845,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2131810438","doi":"10.1053/j.gastro.2008.10.081","title":"Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis","year":2008,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":438,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Tight junction; Colitis; Immune system; Immune Dysfunction; Immunology; Medicine; Cell biology; Cancer research; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.020852326886498,"gpt":0.2355717871243614,"spread":0.2147194602378635,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005687445,0.0001283776,0.0002175601,0.0001395567,0.0002823004,0.000006557857,0.00005290446,0.00005199823,0.00004015027],"category_scores_gemma":[0.00009210666,0.0001173746,0.00002822423,0.0001087808,0.0001666828,0.0001075088,0.00007446401,0.00007310649,0.000007367543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005174823,"about_ca_system_score_gemma":0.00002183086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000189752,"about_ca_topic_score_gemma":0.00001741863,"domain_scores_codex":[0.9990084,0.00007981942,0.0002911691,0.0002775088,0.0001206468,0.0002224703],"domain_scores_gemma":[0.9996434,0.0000403313,0.0001092065,0.00009724886,0.0000580981,0.00005167035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001200961,0.00004557599,0.01496489,0.0000042617,0.00002469283,0.00000199595,0.0009095817,0.000004531503,0.9819247,0.00009333584,0.0004036092,0.0004218688],"study_design_scores_gemma":[0.0007875306,0.0003424369,0.3428043,0.000004157163,0.000005475616,0.00003935658,0.0001561733,0.000005123666,0.6538363,0.00001689069,0.001960288,0.00004197651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880545,0.00003874081,0.01054468,0.000263831,0.0007734528,0.0002066283,0.000009958029,0.0000412021,0.0000670278],"genre_scores_gemma":[0.9986672,0.00001374226,0.0003705071,0.0007361918,0.00005396968,0.00005427925,0.000007320124,0.000008431078,0.00008833154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3280884,"threshold_uncertainty_score":0.4786398,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2007217012","doi":"10.1016/j.febslet.2011.04.066","title":"How do immune cells overcome the blood–brain barrier in multiple sclerosis?","year":2011,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":409,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"Blood–brain barrier; Multiple sclerosis; Immune system; Central nervous system; Inflammation; Immunology; Infiltration (HVAC); Neuroinflammation; Biology; Leukocyte Trafficking; Neuroscience; Chemokine","retraction":null,"screen_n_in":null,"score":{"opus":0.09700781339334512,"gpt":0.2530063073753833,"spread":0.1559984939820381,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003031417,0.0006215585,0.001255499,0.0002399302,0.0003559668,0.0002619196,0.0009134071,0.0002435056,0.0001103902],"category_scores_gemma":[0.0004419013,0.0003846135,0.0005891688,0.0006542669,0.0004119085,0.000210981,0.0003345492,0.0009792979,0.0001323034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000589693,"about_ca_system_score_gemma":0.00004676794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004405798,"about_ca_topic_score_gemma":0.00001445247,"domain_scores_codex":[0.997148,0.0005427889,0.0005356121,0.0008479469,0.0003249181,0.0006007859],"domain_scores_gemma":[0.9976639,0.00090148,0.0003804299,0.000947273,0.00001664067,0.00009029212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006239754,0.0001725984,0.0001356292,0.00639519,0.0005152966,0.0002662538,0.003406023,0.000003755971,0.07080807,0.001632744,0.08251035,0.8340917],"study_design_scores_gemma":[0.0003285788,0.0000228818,0.00008461832,0.001104301,0.0002012621,0.00002546056,0.00002929477,4.179529e-7,0.001021218,0.0000174697,0.9967256,0.0004389592],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00037297,0.9933348,0.00003431813,0.001996614,0.002593507,0.0009802104,0.0001410453,0.00008538912,0.0004611034],"genre_scores_gemma":[0.001456159,0.988291,0.00003517206,0.008040016,0.0003976656,0.0002273923,0.000006492839,0.00008678229,0.001459303],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9142152,"threshold_uncertainty_score":0.9998606,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2089371584","doi":"10.1016/j.bbamem.2008.10.028","title":"Tight junctions as targets of infectious agents","year":2008,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":396,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Simon Fraser University","funders":"Howard Hughes Medical Institute","keywords":"Tight junction; Cell biology; Cell junction; Biology; Occludin; Virulence; Intracellular; Actin cytoskeleton; Cytoplasm; Pathogenesis; Claudin; Cytoskeleton; Transmembrane protein; Microbiology; Cell; Immunology; Genetics; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.05707202358975617,"gpt":0.3296857422970783,"spread":0.2726137187073221,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009162286,0.001168004,0.002542205,0.0009261789,0.0006232071,0.00009967441,0.000852396,0.0006025412,0.000176444],"category_scores_gemma":[0.0003093927,0.0009002807,0.001424639,0.002359021,0.00099357,0.0002912899,0.0004075484,0.0006632624,0.0005464471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008988041,"about_ca_system_score_gemma":0.0004119227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005622618,"about_ca_topic_score_gemma":0.000003790707,"domain_scores_codex":[0.9954854,0.000444524,0.001200267,0.001442144,0.0007424405,0.0006852797],"domain_scores_gemma":[0.9968607,0.0004356809,0.001192248,0.001117675,0.0001401745,0.0002535336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003168403,0.00309591,0.000002156941,0.03515453,0.004146509,0.0002964178,0.003350863,0.000002253543,0.5660767,0.003746366,0.1239964,0.259815],"study_design_scores_gemma":[0.0003577337,0.0002359491,0.00002069843,0.0009310454,0.0006219172,0.0003299003,0.00001542617,0.000001610564,0.08459149,0.0001343263,0.9118894,0.0008705119],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01102021,0.9661558,0.00001087726,0.0004027455,0.006692059,0.001958651,0.001216676,0.0006918011,0.01185115],"genre_scores_gemma":[0.01472712,0.981838,0.00002499758,0.0004512316,0.0006119034,0.0001592091,0.0001623314,0.0001474533,0.001877788],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.787893,"threshold_uncertainty_score":0.9993448,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2047459797","doi":"10.1016/j.semcdb.2015.01.002","title":"Anatomy and physiology of the blood–brain barrier","year":2015,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":380,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Biology; Blood–brain barrier; Neuroscience; Homeostasis; Barrier function; Anatomy; Blood flow; Central nervous system; Physiology; Endocrinology; Cell biology; Internal medicine; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.03100690610510328,"gpt":0.2972347416220131,"spread":0.2662278355169098,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759772,0.0002668798,0.0008576611,0.0001081554,0.00009584436,0.000005637649,0.0001975821,0.0002802529,0.00002513244],"category_scores_gemma":[0.0001662265,0.0001545633,0.0000647443,0.000259986,0.0007167278,0.0000230869,0.0005259459,0.0002697915,0.000003957263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000236529,"about_ca_system_score_gemma":0.0001530548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008338909,"about_ca_topic_score_gemma":0.000007115463,"domain_scores_codex":[0.9986089,0.0002563895,0.000367518,0.000480308,0.000063864,0.0002229499],"domain_scores_gemma":[0.999212,0.0004073737,0.0001804651,0.0001305134,0.00001392826,0.00005573246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002616798,0.00005018558,0.001370891,0.00301978,0.00005873146,0.00001414861,0.001725204,3.103175e-8,0.01140382,0.000628945,0.003245034,0.978457],"study_design_scores_gemma":[0.0002338322,0.00005573748,0.00006360925,0.0003755322,0.00004904162,0.0001496942,0.0001496726,1.677703e-7,0.002206295,0.0006993432,0.9958193,0.0001977218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008085678,0.9881334,4.052218e-7,0.00002788063,0.0004536494,0.0002760362,0.00006507073,0.000008482412,0.002949386],"genre_scores_gemma":[0.003186693,0.995595,0.00009616424,0.0003003137,0.00002751416,0.00003099223,0.000007744324,0.0000118579,0.0007436555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9925743,"threshold_uncertainty_score":0.6302908,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2068462003","doi":"10.1097/wco.0b013e328337f451","title":"Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments","year":2010,"lang":"en","type":"review","venue":"Current Opinion in Neurology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":352,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"","keywords":"Medicine; Traumatic brain injury; Cerebral edema; Edema; Blood–brain barrier; Brain edema; Inflammation; Anesthesia; Neuroscience; Central nervous system; Internal medicine; Psychology","retraction":null,"screen_n_in":null,"score":{"opus":0.1760895799543832,"gpt":0.4070733231384198,"spread":0.2309837431840366,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003041266,0.0004608768,0.00154892,0.0007465022,0.00005888838,0.00001512418,0.00053819,0.0004576268,0.00006700651],"category_scores_gemma":[0.0003518516,0.000379958,0.0001949097,0.0008133758,0.0001867445,0.00007676541,0.0002188819,0.001444483,0.00003308349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002734859,"about_ca_system_score_gemma":0.0002030133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003121188,"about_ca_topic_score_gemma":0.000009126451,"domain_scores_codex":[0.9966053,0.000773474,0.001134126,0.0007747125,0.0002643811,0.0004479932],"domain_scores_gemma":[0.9983839,0.0006201128,0.0005355532,0.0003771419,0.00002143441,0.00006181125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003111755,0.0001074759,0.0001009003,0.005048151,0.000009306925,0.000001914163,0.0002088062,3.447646e-7,0.00003812037,0.009716446,0.0003588216,0.9843786],"study_design_scores_gemma":[0.00041734,0.000187928,0.0004740785,0.001339377,0.00002253239,0.00004533693,0.000005143842,0.000007583107,0.00002495065,0.005180159,0.9919868,0.0003088251],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002027382,0.9667029,0.0002455542,0.0002818842,0.03085166,0.001371883,0.00006471137,0.00005301571,0.0002256291],"genre_scores_gemma":[0.001895482,0.9972739,0.00002822415,0.0003507277,0.0001256298,0.0002447083,0.00001906351,0.0000478072,0.00001440947],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9916279,"threshold_uncertainty_score":0.9998652,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2903766786","doi":"10.3389/fnins.2018.00930","title":"Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier","year":2018,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":337,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"Neuroinflammation; Inflammation; Blood–brain barrier; Immune system; Insulin resistance; Diabetes mellitus; Medicine; Metabolic syndrome; Microglia; Immunology; Systemic inflammation; Neuroscience; Biology; Endocrinology; Central nervous system","retraction":null,"screen_n_in":null,"score":{"opus":0.03452713170780891,"gpt":0.3083703518775999,"spread":0.273843220169791,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006320591,0.0004855148,0.001572726,0.0005624817,0.0003054953,0.0001069315,0.000839806,0.000145107,0.000009272925],"category_scores_gemma":[0.003374317,0.0002717097,0.0004304682,0.00161981,0.002424494,0.0002426862,0.0002519639,0.0005344332,0.000006001369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002212284,"about_ca_system_score_gemma":0.0001746041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000963302,"about_ca_topic_score_gemma":8.299473e-7,"domain_scores_codex":[0.9964631,0.0008465999,0.0007040442,0.001014287,0.000533414,0.0004386117],"domain_scores_gemma":[0.9979321,0.0006334914,0.0005851511,0.0007064026,0.00003243611,0.0001104263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007203837,0.0004054088,0.002682748,0.006711185,0.0002486573,0.0005884688,0.002508623,0.00008522648,0.00168158,0.03855635,0.03157291,0.9142385],"study_design_scores_gemma":[0.001158866,0.0005708778,0.002649288,0.001039996,0.0004060857,0.0007174581,0.00001214922,0.0002282306,0.0001229467,0.0007799023,0.9917488,0.0005654164],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003674175,0.9890702,0.0001915355,0.00008997574,0.00443306,0.001357352,0.0001132901,0.0000456919,0.001024676],"genre_scores_gemma":[0.003452819,0.9953595,0.00005037982,0.0003304988,0.0000837534,0.00007233315,9.921303e-7,0.00003422808,0.0006154855],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9601759,"threshold_uncertainty_score":0.9999735,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2136838641","doi":"10.1038/sj.mn.7800212","title":"Blood—Brain Barrier Permeability Precedes Senile Plaque Formation in an Alzheimer Disease Model","year":2003,"lang":"en","type":"article","venue":"Microcirculation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":336,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Blood–brain barrier; Senile plaques; Disease; Pathology; Alzheimer's disease; Medicine; Permeability (electromagnetism); Chemistry; Internal medicine; Central nervous system; Biochemistry; Membrane","retraction":null,"screen_n_in":null,"score":{"opus":0.04642477081300929,"gpt":0.2784600048518194,"spread":0.2320352340388101,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752565,0.0001524381,0.00013216,0.00009754943,0.0002425707,0.00005861716,0.00007450498,0.00007432375,0.00006737993],"category_scores_gemma":[0.0002961275,0.0001470653,0.00005471122,0.0002209316,0.00006824424,0.0008622939,0.00001772667,0.0001195381,0.00001385063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004861536,"about_ca_system_score_gemma":0.0000459897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007523015,"about_ca_topic_score_gemma":0.0000548246,"domain_scores_codex":[0.998714,0.0002132571,0.0002714174,0.0003995575,0.0001795682,0.0002222267],"domain_scores_gemma":[0.9994411,0.00006599959,0.00007833061,0.0002531999,0.0000524463,0.000108934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006341941,0.0001017471,0.03346818,0.00002588963,0.000006790445,0.000003991157,0.003466383,0.01719814,0.9412552,0.00315182,0.0002201177,0.001038294],"study_design_scores_gemma":[0.001985219,0.00006934471,0.1281,0.00002526217,0.0001533428,0.00004199969,0.0005312685,0.1652804,0.6773999,0.02304173,0.002559786,0.0008118299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918584,0.0001138169,0.006445621,0.0001815964,0.0001190514,0.0003607296,0.00003386678,0.0000763319,0.0008106311],"genre_scores_gemma":[0.9987665,0.000005746112,0.0003010161,0.000760315,0.00003190737,0.00004432015,0.00002308174,0.00001442147,0.00005263312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2638554,"threshold_uncertainty_score":0.599715,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1985775190","doi":"10.1016/j.bbadis.2010.06.017","title":"Disruption of central nervous system barriers in multiple sclerosis","year":2010,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":334,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Blood–brain barrier; Central nervous system; Immune system; Neuroscience; Biology; Pathology; Immunology; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.04223845211617797,"gpt":0.2751515618260183,"spread":0.2329131097098403,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001496685,0.0007966609,0.001971979,0.0004716764,0.0001396467,0.00005837515,0.0008062681,0.000368833,0.00001439288],"category_scores_gemma":[0.0007752969,0.000687893,0.001392536,0.001031319,0.0005536926,0.0001664425,0.0003235627,0.0005871721,0.00000953493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000109873,"about_ca_system_score_gemma":0.0004848036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004275045,"about_ca_topic_score_gemma":0.000005268585,"domain_scores_codex":[0.9957479,0.000613605,0.001180117,0.001141273,0.0007149409,0.0006021817],"domain_scores_gemma":[0.9968082,0.0002409346,0.001105516,0.001179751,0.00009724711,0.0005683833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005751254,0.0006710126,0.00002642667,0.03531708,0.0004119734,0.0000850022,0.0004023209,0.00001155678,0.8534046,0.00179431,0.0001864534,0.1071142],"study_design_scores_gemma":[0.002766866,0.0004595071,0.005391318,0.02825835,0.006399902,0.00001916263,0.0003218695,0.0001728132,0.921955,0.0001209335,0.03071294,0.003421375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5354062,0.4553033,0.00008315399,0.0001828074,0.001536413,0.002678598,0.00436153,0.0001972663,0.0002507177],"genre_scores_gemma":[0.6555634,0.3439356,0.00005926261,0.00007350365,0.00007611237,0.0001183537,0.00008423535,0.00008277997,0.000006791764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1201572,"threshold_uncertainty_score":0.9995572,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2006572450","doi":"10.1002/glia.1104","title":"Glial cell influence on the human blood‐brain barrier","year":2001,"lang":"en","type":"review","venue":"Glia","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":320,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Biology; Blood–brain barrier; Immune system; Cell biology; Chemokine; Microglia; Cell adhesion molecule; Neuroinflammation; Inflammation; Major histocompatibility complex; Central nervous system; Antigen presentation; Neuroscience; Immunology; T cell","retraction":null,"screen_n_in":null,"score":{"opus":0.06558439294452495,"gpt":0.3202745893432877,"spread":0.2546901963987628,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001950142,0.0004984796,0.0008336392,0.0001088037,0.0007481063,0.0001280415,0.0007803258,0.0002449094,0.0006195926],"category_scores_gemma":[0.0006107038,0.0002846469,0.0003935213,0.0005562269,0.0002868069,0.00006867501,0.00019287,0.0008099847,0.0007955637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003199015,"about_ca_system_score_gemma":0.00008509011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001242928,"about_ca_topic_score_gemma":0.000004488545,"domain_scores_codex":[0.9976515,0.0003276272,0.0004563596,0.0007192187,0.0004236415,0.0004216559],"domain_scores_gemma":[0.9980994,0.000633034,0.0002893453,0.0008372359,0.0000347095,0.0001062047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003003564,0.0002433297,0.00005371165,0.007853786,0.0002548276,0.00063027,0.001035385,0.000005516534,0.003040824,0.03781916,0.3108439,0.6381892],"study_design_scores_gemma":[0.0001133112,0.00007253967,0.000006259037,0.0006442479,0.0002248378,0.00003416899,0.000009441703,1.03725e-7,0.0004128962,0.0003456378,0.9978263,0.0003102891],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000480318,0.943495,0.00000299182,0.000181066,0.001363408,0.0007674551,0.0001374802,0.0001399745,0.05343225],"genre_scores_gemma":[0.0004481586,0.9801572,0.000004354669,0.003248562,0.0007151868,0.0001344678,0.000004603587,0.00005251787,0.01523494],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6869823,"threshold_uncertainty_score":0.9999824,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2146367607","doi":"10.1136/gut.2008.150888","title":"Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse","year":2008,"lang":"en","type":"article","venue":"Gut","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":319,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Vernon Jubilee Hospital; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Spermine; Ethylmorphine; Spermidine; Putrescine; Chemistry; Biochemistry; Hydroxylation; Microsome; Demethylation; Acetanilide; Pharmacology; Biology; Enzyme; Organic chemistry; Gene expression","retraction":null,"screen_n_in":null,"score":{"opus":0.07093346993829336,"gpt":0.2586804721698651,"spread":0.1877470022315718,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059122,0.0001135435,0.0001277733,0.00004679647,0.0003733238,0.00002707044,0.0002219954,0.0000311176,0.00003025335],"category_scores_gemma":[0.0008143554,0.0000770793,0.00004879027,0.0002711524,0.0002930389,0.00005151163,0.00007886111,0.0002035552,0.0000467055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003730039,"about_ca_system_score_gemma":0.00003602815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001736169,"about_ca_topic_score_gemma":0.00007483418,"domain_scores_codex":[0.9988611,0.0001435857,0.0001947864,0.0003460837,0.0001945418,0.0002599368],"domain_scores_gemma":[0.9993234,0.0002529964,0.00004740995,0.0002998845,0.00003999039,0.00003635356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002931199,0.0004618411,0.2007687,0.00007905244,0.00001561529,0.0004951531,0.05589791,0.0008829177,0.7157519,0.00483616,0.01140503,0.009112586],"study_design_scores_gemma":[0.0008273415,0.0002757224,0.778772,0.00002792089,0.0000206842,0.001654598,0.002711232,0.0006314616,0.1961951,0.001167177,0.01720564,0.0005111102],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952108,0.00005691916,0.0000881625,0.0007451102,0.0002633118,0.0001647277,0.0000117356,0.00005222282,0.003406995],"genre_scores_gemma":[0.9978241,0.00002905647,0.0001571879,0.001418405,0.00009441355,0.00003041842,9.320964e-7,0.000007294987,0.0004382156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5780033,"threshold_uncertainty_score":0.3143203,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2144960514","doi":"10.1111/j.1750-3639.2000.tb00248.x","title":"Inflammatory Mediators of Cerebral Endothelium: A Role in Ischemic Brain Inflammation","year":2000,"lang":"en","type":"review","venue":"Brain Pathology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":316,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Heart and Stroke Foundation of Canada","keywords":"Inflammation; Chemokine; Blood–brain barrier; Cell adhesion molecule; Neuroinflammation; Proinflammatory cytokine; Microglia; Ischemia; Immunology; Endothelium; Medicine; Vascular permeability; Brain ischemia; Central nervous system; Pathology; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.02049773650850966,"gpt":0.2808785507519793,"spread":0.2603808142434696,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004074834,0.0004780296,0.001610106,0.000663301,0.00007080205,0.0000142052,0.0004374382,0.0006196883,0.0002432156],"category_scores_gemma":[0.001134206,0.0004127001,0.0003216339,0.0006072322,0.0003601509,0.0001332592,0.0001585188,0.0006427808,0.0001408421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006769298,"about_ca_system_score_gemma":0.0002546659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005050766,"about_ca_topic_score_gemma":0.00002553676,"domain_scores_codex":[0.9965863,0.0008298123,0.001137706,0.0007371629,0.0002605256,0.000448479],"domain_scores_gemma":[0.9975325,0.001230195,0.0006300151,0.0005050422,0.0000240234,0.00007815016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002745432,0.00002085453,0.00008666452,0.002541292,0.0000212113,0.0001503788,0.001125512,0.000002188022,0.003065092,0.000807927,0.002864608,0.9892868],"study_design_scores_gemma":[0.0004179403,0.00004982077,0.00003736565,0.0006336683,0.00005665292,0.000320241,0.00004061533,0.000002103591,0.001181374,0.000418102,0.996514,0.0003281032],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003819092,0.9827296,0.00001483308,0.0002617756,0.0007368343,0.0009129558,0.000143981,0.0001166356,0.01126427],"genre_scores_gemma":[0.000750694,0.9971359,0.00006097119,0.000624667,0.0004297905,0.0002543228,0.00003750361,0.00007731877,0.0006288028],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9936494,"threshold_uncertainty_score":0.9998325,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3048754617","doi":"10.1038/s41586-020-2589-x","title":"Interpericyte tunnelling nanotubes regulate neurovascular coupling","year":2020,"lang":"en","type":"article","venue":"Nature","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":312,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre; Université de Montréal; Montreal General Hospital","funders":"","keywords":"Neurovascular bundle; Pericyte; Retina; Cell biology; Coupling (piping); Gap junction; Neuroscience; Biology; Organelle; Intracellular; Anatomy; Biophysics; Chemistry; Endothelial stem cell; Materials science; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.02181474747684482,"gpt":0.2474346281328039,"spread":0.2256198806559591,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004857179,0.0001565922,0.0001820766,0.00003418163,0.000219959,0.00006121637,0.0002204059,0.0003522329,0.00006521125],"category_scores_gemma":[0.0005001638,0.000127177,0.0001138248,0.0003917333,0.00006488363,0.0001295813,0.0001090307,0.001492257,0.00006063071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009465106,"about_ca_system_score_gemma":0.00001313612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000101689,"about_ca_topic_score_gemma":4.014036e-7,"domain_scores_codex":[0.9989022,0.00002342854,0.0001474149,0.0004557368,0.0002589468,0.0002122721],"domain_scores_gemma":[0.9995595,0.00007264501,0.00004664971,0.0001823751,0.00004128172,0.00009755367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000153302,0.00001490433,0.0006417417,0.00006803754,0.00003625914,0.0001305366,0.00206612,0.002107953,0.9762697,0.002912128,0.01175621,0.003843128],"study_design_scores_gemma":[0.0005603581,0.0001169143,0.001106484,0.00002933782,0.00004697626,0.00004567825,0.0002076414,0.01529418,0.6053407,0.0005225645,0.3763099,0.0004192524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772814,0.002761421,0.002687682,0.01038769,0.002828218,0.0002483844,0.00001433627,0.0005642743,0.003226602],"genre_scores_gemma":[0.980193,0.0001342032,0.0001373892,0.01892077,0.0004341823,0.00000366554,0.000001010496,0.00002165561,0.0001541859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.370929,"threshold_uncertainty_score":0.6483195,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2063038783","doi":"10.1371/journal.pone.0023789","title":"Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":295,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Hypervascularity; Blood–brain barrier; Occludin; Angiogenesis; Cerebral amyloid angiopathy; Neuroinflammation; Vascular permeability; Pathology; Tight junction; Biology; Alzheimer's disease; Medicine; Neuroscience; Cancer research; Cell biology; Disease; Central nervous system; Dementia","retraction":null,"screen_n_in":null,"score":{"opus":0.09338783676248032,"gpt":0.2365221214041551,"spread":0.1431342846416748,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798655,0.0002134013,0.0003496901,0.0001147701,0.000257056,0.0000329447,0.0001016798,0.00007164625,0.0001545569],"category_scores_gemma":[0.0009873478,0.0001958173,0.000104138,0.0002985688,0.0003390193,0.0002337702,0.0001388608,0.0001637735,0.000007488727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001888948,"about_ca_system_score_gemma":0.00004709578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001448351,"about_ca_topic_score_gemma":0.00005846502,"domain_scores_codex":[0.9982285,0.0002209075,0.0002443973,0.0006487249,0.0003178516,0.0003396079],"domain_scores_gemma":[0.9990537,0.0001607761,0.00006358542,0.0003909316,0.00007689837,0.0002540771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000382492,0.001585075,0.8211161,0.0001052255,0.0005242829,0.0002013551,0.004726685,0.000001613891,0.1694522,0.0004174294,0.00007123492,0.001416342],"study_design_scores_gemma":[0.001246791,0.00009979363,0.8095741,0.00004626091,0.0009618056,0.00001220306,0.0002626936,0.0001395451,0.1857823,0.001406011,0.00005065131,0.0004178549],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973485,0.001296697,0.00001009068,0.0003786051,0.00008202168,0.0003551761,0.00005472426,0.00007107126,0.0004030907],"genre_scores_gemma":[0.9980896,0.00006035599,0.0003621426,0.001334564,0.00006316043,0.00003546696,0.000001690659,0.0000205589,0.00003248321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01633012,"threshold_uncertainty_score":0.7985198,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2001267675","doi":"10.1016/j.jneuroim.2010.08.011","title":"Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":279,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Multiple sclerosis; Experimental autoimmune encephalomyelitis; Blood–brain barrier; Tight junction; Central nervous system; Encephalomyelitis; Immunology; Inflammation; Endothelium; Pathology; Endothelial stem cell; Medicine; Vascular permeability; Biology; In vitro; Neuroscience; Cell biology","retraction":null,"screen_n_in":null,"score":{"opus":0.03879977624955712,"gpt":0.255052669892864,"spread":0.2162528936433069,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004594363,0.000128994,0.0002460034,0.0001182848,0.0001950193,0.00003929234,0.0002707861,0.00009895072,0.0000164119],"category_scores_gemma":[0.002359331,0.00008328951,0.0001025236,0.000178487,0.000376892,0.0002259272,0.00007751464,0.0008611959,0.000001862007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007347808,"about_ca_system_score_gemma":0.00003151522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005798105,"about_ca_topic_score_gemma":0.00003004845,"domain_scores_codex":[0.9987022,0.0003030829,0.0003689599,0.0002280001,0.0001953292,0.0002024798],"domain_scores_gemma":[0.9988279,0.0005889894,0.0001998241,0.0002762748,0.00006976629,0.00003720071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008066328,0.00005710868,0.002318691,0.000003888324,0.000009710063,0.000009335857,0.001304687,0.00007209913,0.9939811,0.0002852221,0.00003317736,0.001844362],"study_design_scores_gemma":[0.002425577,0.0005019386,0.9317555,0.00001274365,0.00006669229,0.0006873097,0.0004629543,0.001254,0.05708159,0.004000497,0.001550716,0.0002005223],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969588,0.000131498,0.0003315744,0.001681992,0.0006283903,0.0001126804,0.000004373294,0.000009189752,0.0001415191],"genre_scores_gemma":[0.9982007,0.0002677826,0.0001183974,0.001307022,0.0000704896,0.000006001223,1.377978e-7,0.000008806596,0.00002069101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9368995,"threshold_uncertainty_score":0.3741516,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2792281792","doi":"10.7554/elife.34861","title":"Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection","year":2018,"lang":"en","type":"article","venue":"eLife","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":279,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Seventh Framework Programme; National Institutes of Health; National Eye Institute; Center for Visual Science; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Canadian Institutes of Health Research; University of Rochester; Research to Prevent Blindness","keywords":"Actin; Pericyte; Cell biology; Biology; Cytoskeleton; SMA*; Immunolabeling; Biophysics; Cell; Endothelial stem cell; Biochemistry; Immunology; In vitro","retraction":null,"screen_n_in":null,"score":{"opus":0.03897017070858116,"gpt":0.297124839631447,"spread":0.2581546689228658,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009186086,0.0001330572,0.0001665107,0.00008353322,0.0003625622,0.00003486104,0.0001063033,0.00007475055,0.00006078728],"category_scores_gemma":[0.0008191492,0.0001227713,0.0000650019,0.0003281598,0.0001111281,0.000284965,0.00005130926,0.00006189683,0.000005835931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001729581,"about_ca_system_score_gemma":0.00003332394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003317343,"about_ca_topic_score_gemma":0.00004726766,"domain_scores_codex":[0.9988589,0.00007706393,0.0002728254,0.0003329774,0.0002594186,0.0001988445],"domain_scores_gemma":[0.999225,0.0001263179,0.0002469027,0.0002139998,0.0001426568,0.00004515539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001146687,0.0000257424,0.0001291302,0.00003064462,0.000007615101,1.634555e-7,0.0006902536,0.000004650748,0.9796922,0.00005881782,0.0003871004,0.01885901],"study_design_scores_gemma":[0.0003268504,0.0003778557,0.005255142,0.00001856929,0.00002206983,0.000002742228,0.0003409442,0.0002377514,0.9767264,0.00007794329,0.01649162,0.0001221155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535505,0.0001460518,0.04277096,0.00009793665,0.001409579,0.0004284863,0.00002051679,0.0001268781,0.001449115],"genre_scores_gemma":[0.9983957,0.0000852879,0.0004553495,0.0001989726,0.0004923595,0.00007414589,0.000005237842,0.00002133256,0.0002716005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04484523,"threshold_uncertainty_score":0.500647,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1981910576","doi":"10.1136/gut.47.1.112","title":"Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse","year":2000,"lang":"en","type":"article","venue":"Gut","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":274,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"","keywords":"Paracellular transport; Transcellular; Glucagon-like peptide-2; Barrier function; Chemistry; Intestinal epithelium; Tight junction; Intestinal mucosa; Internal medicine; Endocrinology; Biophysics; Cell biology; Biochemistry; Biology; Epithelium; Peptide; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.02232718627528908,"gpt":0.2231469653588954,"spread":0.2008197790836063,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311845,0.0001531589,0.0001864231,0.00005612469,0.0001741138,0.00003146791,0.0001463391,0.00005481885,0.000283675],"category_scores_gemma":[0.00006552682,0.0001040643,0.00005937501,0.0002143264,0.000263045,0.000131277,0.00001478364,0.0001884405,0.00002704536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007279438,"about_ca_system_score_gemma":0.000021795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005496609,"about_ca_topic_score_gemma":0.00004505818,"domain_scores_codex":[0.998813,0.0001517657,0.0002601365,0.000316941,0.0002451474,0.0002129776],"domain_scores_gemma":[0.9995449,0.0001448924,0.00006091527,0.0001902389,0.00001740656,0.00004165927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002106456,0.00004016177,0.001004647,0.00002220777,0.000006446624,0.00001478489,0.002997748,0.00002346063,0.9827176,0.0006654836,0.0002266118,0.01207024],"study_design_scores_gemma":[0.001681915,0.0008521988,0.01805901,0.00004954672,0.00009451473,0.00009870568,0.001706702,0.0004370212,0.861421,0.003717459,0.1113757,0.0005061926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950973,0.0004560519,0.000982292,0.00009905969,0.0001906392,0.0001816615,0.0000222611,0.00003078714,0.002939902],"genre_scores_gemma":[0.9980744,0.0002463014,0.00004989786,0.0005319598,0.00009159729,0.00002133279,0.000002022701,0.00001018265,0.0009723755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1212966,"threshold_uncertainty_score":0.4243617,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2124077349","doi":"10.1016/j.nbd.2015.02.029","title":"Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":271,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institute of Neurological Disorders and Stroke; Korea National Institute of Health; Israel Science Foundation","keywords":"Synaptogenesis; Epilepsy; Excitatory postsynaptic potential; Neuroscience; Blood–brain barrier; Albumin; Medicine; Psychology; Internal medicine; Central nervous system; Inhibitory postsynaptic potential","retraction":null,"screen_n_in":null,"score":{"opus":0.05545092943354681,"gpt":0.271447515731039,"spread":0.2159965862974922,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002406528,0.0002663094,0.0005109967,0.0002049405,0.0001045405,0.000008575212,0.0002601425,0.0001322906,0.00001905449],"category_scores_gemma":[0.001397702,0.0002458684,0.0002086446,0.00037148,0.0004240436,0.0002671061,0.0001117459,0.0001127937,0.000004605482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002821118,"about_ca_system_score_gemma":0.0002200158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001867548,"about_ca_topic_score_gemma":0.000005037073,"domain_scores_codex":[0.9978138,0.0004012939,0.0005695348,0.0006182343,0.0002358479,0.0003612527],"domain_scores_gemma":[0.9987137,0.0003940066,0.0002723599,0.000344733,0.00007556289,0.0001996711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000689924,0.0001257561,0.01667216,0.0000517518,0.00004603747,0.00001269364,0.001005484,0.004487591,0.976356,0.0002621136,0.0001976709,0.00009284443],"study_design_scores_gemma":[0.004892341,0.0009102862,0.01161216,0.0001065461,0.00043352,0.000005848138,0.001116286,0.001426445,0.974176,0.004606849,0.0001145478,0.0005991693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978055,0.0001974227,0.0005337392,0.000186201,0.0006869377,0.0002546546,0.00007907477,0.00005107327,0.0002054394],"genre_scores_gemma":[0.998615,0.00001400415,0.0001801054,0.001008885,0.00005299611,0.0000439063,0.000006598896,0.00002591425,0.00005263314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005059997,"threshold_uncertainty_score":0.9999993,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2006610133","doi":"10.1016/j.expneurol.2004.08.008","title":"Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood–brain barrier","year":2004,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":265,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Nitric oxide; Chemistry; Blood–brain barrier; Soluble guanylyl cyclase; Sodium nitroprusside; Endothelial stem cell; In vitro; Permeability (electromagnetism); Enos; Pharmacology; Nitric oxide synthase; Biochemistry; Endocrinology; Biology; Central nervous system","retraction":null,"screen_n_in":null,"score":{"opus":0.02155529038482657,"gpt":0.2637193752342104,"spread":0.2421640848493838,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120011,0.0001400602,0.0002188234,0.00005627203,0.0001907226,0.000007034716,0.0002645164,0.00006654715,0.000009615518],"category_scores_gemma":[0.00009160574,0.0000859997,0.00005828437,0.0001966612,0.0008236909,0.00008998379,0.0002310795,0.0002053786,3.098021e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008665551,"about_ca_system_score_gemma":0.00001928774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001153431,"about_ca_topic_score_gemma":0.00001045165,"domain_scores_codex":[0.9988071,0.0002186043,0.0002722716,0.000359676,0.0001569353,0.0001854131],"domain_scores_gemma":[0.999371,0.00007972459,0.0001067277,0.0003900216,0.00001478054,0.00003775748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255747,0.0001119526,0.001234313,0.000003775917,0.000003568793,0.000002802695,0.0008357328,0.0008175455,0.9956492,0.001177819,0.000003013432,0.00003475576],"study_design_scores_gemma":[0.0008570531,0.0002007701,0.017091,0.0000010616,0.000005651413,0.0000401783,0.00009422909,0.0007461642,0.9777593,0.00311976,0.00001523689,0.00006960455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988584,0.0001117271,0.00001145561,0.0004761601,0.000092731,0.0002279711,0.00002310068,0.00001407711,0.0001844132],"genre_scores_gemma":[0.9978659,0.000003885938,0.00002567152,0.002045031,0.0000155556,0.00001677975,5.608405e-7,0.00001159289,0.00001507674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01788986,"threshold_uncertainty_score":0.3506966,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1964426997","doi":"10.1016/j.neuroimage.2006.12.040","title":"Three-dimensional cerebral vasculature of the CBA mouse brain: A magnetic resonance imaging and micro computed tomography study","year":2007,"lang":"en","type":"article","venue":"NeuroImage","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":265,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Sunnybrook Research Institute","keywords":"Magnetic resonance imaging; Circle of Willis; Computed tomography; Cerebral circulation; Atlas (anatomy); Cerebral arteries; Tomography; Pulmonary vasculature; Brain atlas; Neuroimaging; Medicine; Anatomy; Biology; Neuroscience; Radiology; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.01337156806029806,"gpt":0.2314323208730093,"spread":0.2180607528127113,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001846615,0.0001960736,0.0002097346,0.0001052409,0.0003231859,0.00004546341,0.0002434551,0.00003432911,0.00001574987],"category_scores_gemma":[0.0001562617,0.0001375711,0.0001060854,0.0006044745,0.0004238115,0.0001124825,0.0003098922,0.0003148567,0.000001808746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000593949,"about_ca_system_score_gemma":0.00001426382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002958927,"about_ca_topic_score_gemma":0.00007720206,"domain_scores_codex":[0.9984671,0.0000986079,0.0002535721,0.000517058,0.0003757551,0.0002879066],"domain_scores_gemma":[0.9990655,0.0002726762,0.00009557291,0.0004357978,0.00006741416,0.00006300123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001744813,0.0002051295,0.3968064,0.00002398015,0.00001058178,0.00009874991,0.0008175753,0.000007408472,0.5845155,0.0002536402,0.007099521,0.009987009],"study_design_scores_gemma":[0.0009514019,0.0001246123,0.962558,0.00001040321,0.00002045361,0.00008402633,0.00006177637,0.0001509616,0.03236115,0.0001754635,0.003357316,0.0001443986],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965696,0.001320362,0.0001166885,0.0006386961,0.0004994259,0.0004312852,0.00002459318,0.00006738816,0.0003319769],"genre_scores_gemma":[0.9964584,0.000002587677,0.0002362088,0.003088556,0.00006773879,0.000003261341,3.61107e-7,0.00002017578,0.0001227111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5657516,"threshold_uncertainty_score":0.5609987,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2039857463","doi":"10.1523/jneurosci.2088-07.2007","title":"Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":259,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"Occludin; Angiotensin II; Blood–brain barrier; Tight junction; Proinflammatory cytokine; Astrocyte; Cell biology; Biology; Angiotensin II receptor type 1; Inflammation; Endocrinology; Chemistry; Receptor; Immunology; Central nervous system; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.05898914752599372,"gpt":0.2779302780836258,"spread":0.2189411305576321,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0009995393,0.0002160797,0.0003658271,0.000262386,0.0007930968,0.0001064359,0.0002971306,0.00007335722,0.000005127925],"category_scores_gemma":[0.01106779,0.0001702626,0.0001512064,0.00070367,0.0003423028,0.0005765488,0.0001303754,0.0002353601,0.000001824609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003466606,"about_ca_system_score_gemma":0.00005668896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002513534,"about_ca_topic_score_gemma":0.000005470697,"domain_scores_codex":[0.9977007,0.00005727496,0.0006144078,0.000536815,0.0005503882,0.000540396],"domain_scores_gemma":[0.9976526,0.0008870693,0.0005668811,0.0002317655,0.0003188603,0.0003428416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006715567,0.0000347122,0.001072913,0.00000599226,0.000004289838,0.00001567512,0.0002637364,0.00002401263,0.9851043,0.0003472991,0.0093985,0.003057026],"study_design_scores_gemma":[0.005549281,0.005079661,0.2033955,0.0001588657,0.000124025,0.0008608899,0.0002634223,0.0006000131,0.5952457,0.002764609,0.1853597,0.0005983418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9254134,0.0001993389,0.06213538,0.008558344,0.003054024,0.0004618613,0.00004890845,0.0000366042,0.00009208254],"genre_scores_gemma":[0.970131,0.0001074603,0.001540543,0.02720726,0.0003069862,0.000005518704,7.690483e-8,0.00001889872,0.0006822739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3898585,"threshold_uncertainty_score":0.9972624,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1964508300","doi":"10.1371/journal.pone.0020599","title":"Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":239,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Lakehead University","keywords":"Occludin; Tight junction; Blood–brain barrier; Cell biology; Claudin; Biology; Extracellular matrix; Matrix metalloproteinase; Leukemia; Chemistry; Cancer research; Immunology; Central nervous system; Neuroscience; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.03556663158590956,"gpt":0.2148274307559191,"spread":0.1792607991700095,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003441581,0.0002136136,0.0003111912,0.00004551401,0.0003732341,0.0000309086,0.0001864573,0.00009136869,0.0002898312],"category_scores_gemma":[0.0007901503,0.0001468026,0.0000644308,0.0002476346,0.0004377399,0.0001994472,0.000138516,0.0002603292,0.000007932239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001707441,"about_ca_system_score_gemma":0.00002972307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003568059,"about_ca_topic_score_gemma":0.000008551197,"domain_scores_codex":[0.9982723,0.0002696227,0.0003351753,0.0004781642,0.0003849976,0.0002597354],"domain_scores_gemma":[0.9990311,0.0001752512,0.0002079404,0.000395008,0.00007501237,0.0001156609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001087858,0.0002207154,0.0009680744,0.0001120725,0.0001092676,0.000001395102,0.0009338047,8.127736e-8,0.9969409,0.00009872507,0.0003635983,0.0001426026],"study_design_scores_gemma":[0.0004669357,0.0002039818,0.0006027793,0.00002630373,0.0003534096,0.000005432868,0.0002255181,0.00009788491,0.9968828,0.0003163369,0.0006481723,0.0001704716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970927,0.0005303582,0.000120457,0.000206627,0.00005527366,0.0008471482,0.0001484999,0.00008110668,0.0009177995],"genre_scores_gemma":[0.9973422,0.00005047268,0.0002995949,0.0002876153,0.00004171918,0.0001025147,0.00000537718,0.00002326506,0.001847286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009294869,"threshold_uncertainty_score":0.5986437,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3000536289","doi":"10.3390/ijms21020591","title":"Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":232,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Israel Science Foundation; National Institutes of Health; Stiftung Tierärztliche Hochschule Hannover; Deutsche Forschungsgemeinschaft; European Commission; U.S. Department of Defense","keywords":"Epileptogenesis; Epilepsy; Blood–brain barrier; Neuroscience; Medicine; Biology; Central nervous system","retraction":null,"screen_n_in":null,"score":{"opus":0.05843126002386059,"gpt":0.3217337436129822,"spread":0.2633024835891216,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002720214,0.0003037206,0.0006997927,0.0003292951,0.0003407819,0.0002205345,0.0006954665,0.0001016816,0.00006590576],"category_scores_gemma":[0.00129473,0.0001750907,0.0003162517,0.0005576152,0.001242753,0.0002676194,0.0003482188,0.0003467568,8.278953e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003439314,"about_ca_system_score_gemma":0.0006645733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000577681,"about_ca_topic_score_gemma":0.000004129418,"domain_scores_codex":[0.9971371,0.0003401589,0.000828911,0.0004425991,0.001066016,0.0001851694],"domain_scores_gemma":[0.9979826,0.0004555644,0.001033143,0.0001478412,0.0002444631,0.0001363949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006569928,0.0002189978,0.003079735,0.004760695,0.006912969,0.01054888,0.002506766,0.0009098575,0.4638061,0.07389161,0.001287192,0.4314202],"study_design_scores_gemma":[0.005071326,0.001759773,0.003159069,0.01296278,0.005571076,0.1223867,0.0007519605,0.0002602808,0.1552686,0.009663536,0.680171,0.002973952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09436306,0.9002042,0.0004411299,0.001969753,0.002198184,0.0003955157,0.0002011891,0.00001454919,0.0002124052],"genre_scores_gemma":[0.1631241,0.8344702,0.0005804117,0.001340844,0.000283903,0.00001805405,0.000001755001,0.0000301714,0.0001505042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6788837,"threshold_uncertainty_score":0.713999,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2150094514","doi":"10.1242/dev.129.7.1775","title":"Permeability barrier dysfunction in transgenic mice overexpressing claudin 6","year":2002,"lang":"en","type":"article","venue":"Development","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":229,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Involucrin; Biology; Claudin; Loricrin; Filaggrin; Genetically modified mouse; Cell biology; Transgene; Tight junction; Downregulation and upregulation; KLF4; Premature aging; Immunology; Keratinocyte; Genetics; Gene; SOX2; Embryonic stem cell; Cell culture","retraction":null,"screen_n_in":null,"score":{"opus":0.0492012111736681,"gpt":0.2417911184575867,"spread":0.1925899072839186,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001431005,0.0001547828,0.0001593422,0.00009794691,0.0002535108,0.0000360773,0.0001056704,0.00006684825,0.001011021],"category_scores_gemma":[0.0001472538,0.0001388001,0.00004174655,0.0002934376,0.00007062161,0.0001748177,0.00004291627,0.0001762444,0.0001352951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001363245,"about_ca_system_score_gemma":0.00002830657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005620685,"about_ca_topic_score_gemma":0.00003296347,"domain_scores_codex":[0.9986392,0.00007974775,0.0002974463,0.0004421851,0.000257918,0.0002835579],"domain_scores_gemma":[0.9996306,0.00007807119,0.00004680048,0.0001551654,0.00002151532,0.00006781315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000159673,0.0002786994,0.04357269,0.0001113762,0.0000334406,0.00002238994,0.03238641,0.0001102987,0.7496751,0.0006034794,0.009009929,0.1640365],"study_design_scores_gemma":[0.001480425,0.0000432148,0.2005058,0.00005102538,0.00001117224,0.00002371528,0.0004660091,0.0004558269,0.4494581,0.0004029525,0.346519,0.0005828385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837407,0.0001422931,0.0008831347,0.0002724627,0.0009031989,0.0001946011,0.000003871841,0.00008872084,0.01377099],"genre_scores_gemma":[0.9970183,0.0000312291,0.0005664791,0.0008523145,0.00006106136,0.00003872246,9.04904e-7,0.00001095562,0.001419997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.337509,"threshold_uncertainty_score":0.9999022,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2111982133","doi":"10.1007/s00401-009-0541-0","title":"Pathology and new players in the pathogenesis of brain edema","year":2009,"lang":"en","type":"review","venue":"Acta Neuropathologica","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":228,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; University of Toronto","funders":"","keywords":"Pathogenesis; Edema; Medicine; Magic bullet; Pathology; Cerebral edema; Brain edema; Aquaporin 4; Bioinformatics; Biology; Anesthesia; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.1141916155003895,"gpt":0.326075434339116,"spread":0.2118838188387264,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004685817,0.0004777588,0.001454219,0.0002345195,0.0001451621,0.00003743391,0.0006728125,0.0003109635,0.00001997551],"category_scores_gemma":[0.002171133,0.0002674535,0.0002560042,0.0007025451,0.0003165702,0.00006773846,0.0002176383,0.0005762413,0.00001049027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001099338,"about_ca_system_score_gemma":0.00007809609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002324873,"about_ca_topic_score_gemma":0.000002273659,"domain_scores_codex":[0.9961094,0.00172623,0.0006697777,0.0008703487,0.0002469657,0.0003773257],"domain_scores_gemma":[0.9970067,0.001820287,0.0004700722,0.0006161148,0.00001580077,0.00007099922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001380451,0.00003729241,0.00001608774,0.0004398867,0.000003706883,0.001794476,0.0003774169,1.748702e-7,0.001618869,0.0007345434,0.002343516,0.9926202],"study_design_scores_gemma":[0.0001759911,0.00036801,0.001799948,0.000273715,0.000146882,0.003702417,0.00004306609,3.370388e-7,0.00002297389,0.0003963035,0.9927835,0.0002868968],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001272119,0.9945225,0.00001664253,0.0007836204,0.0003675862,0.0006935318,0.00005494602,0.00005575714,0.002233327],"genre_scores_gemma":[0.004745582,0.9909167,0.00006042886,0.003906645,0.0001274526,0.00003321328,0.000003681638,0.00002628247,0.0001799601],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9923334,"threshold_uncertainty_score":0.9999778,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2153753664","doi":"10.1016/s0002-9440(10)61243-6","title":"Transforming Growth Factor-β Regulation of Epithelial Tight Junction Proteins Enhances Barrier Function and Blocks Enterohemorrhagic Escherichia coli O157:H7-Induced Increased Permeability","year":2005,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":222,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Occludin; Tight junction; Paracellular transport; Barrier function; Claudin; Cell biology; Biology; Signal transduction; MAPK/ERK pathway; Epithelium; Cell junction; Adherens junction; Cadherin; Permeability (electromagnetism); Cell; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01325719778027706,"gpt":0.2395124931222483,"spread":0.2262552953419713,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003331689,0.0002026199,0.0005051176,0.0002008518,0.0001895016,0.00001744985,0.0001126792,0.00008391793,0.0001013688],"category_scores_gemma":[0.0003623727,0.0001600763,0.0001275416,0.0003158169,0.0005477172,0.0003743808,0.00002411939,0.0003170276,0.000001663288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005732256,"about_ca_system_score_gemma":0.00008093802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003401326,"about_ca_topic_score_gemma":0.00001897453,"domain_scores_codex":[0.9981401,0.0003855184,0.0006369803,0.0003090017,0.0002959832,0.0002324],"domain_scores_gemma":[0.9985716,0.0001483286,0.0007849426,0.0001427658,0.0002313932,0.0001209283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006612903,0.00005652157,0.004665665,0.00001383648,0.00002059458,0.000006113511,0.001096772,0.000004953225,0.9604736,0.00008284824,0.000009545587,0.03290824],"study_design_scores_gemma":[0.001121613,0.002637689,0.1254336,0.00002230756,0.0001056257,0.0003669134,0.00075693,0.0000852523,0.8682387,0.0006036041,0.0004366538,0.0001910496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900641,0.00004456393,0.008619483,0.0002866711,0.0005026547,0.0002186767,0.00001432893,0.0000205968,0.0002288535],"genre_scores_gemma":[0.9985259,0.00005145652,0.0007289897,0.000310634,0.0003300865,0.000009551262,8.37575e-7,0.00001366349,0.00002888986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1207679,"threshold_uncertainty_score":0.6527721,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1598970150","doi":"10.1046/j.1471-4159.2002.01201.x","title":"High transcytosis of melanotransferrin (P97) across the blood–brain barrier","year":2002,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":217,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Transcytosis; Blood–brain barrier; Endocytosis; Transferrin receptor; Transferrin; Cell biology; Receptor; Tight junction; Receptor-mediated endocytosis; Vesicular transport protein; Biology; Recombinant DNA; Biophysics; Biochemistry; Neuroscience; Central nervous system; Gene; Vesicle","retraction":null,"screen_n_in":null,"score":{"opus":0.025810652096422,"gpt":0.2455122823724814,"spread":0.2197016302760594,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154853,0.0001741665,0.0003172312,0.00002767344,0.0002016971,0.00003437059,0.0004824699,0.00008171848,0.0003443193],"category_scores_gemma":[0.0004865985,0.0001126515,0.0002695169,0.0002505772,0.0002763449,0.000121989,0.00003222927,0.0004791082,0.000003308406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000808721,"about_ca_system_score_gemma":0.0000174167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002005148,"about_ca_topic_score_gemma":6.971162e-7,"domain_scores_codex":[0.9984596,0.00007591222,0.0005489745,0.0001947877,0.000474906,0.0002458239],"domain_scores_gemma":[0.9988654,0.0003789797,0.0002791509,0.0002618517,0.000107555,0.0001070827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006450467,0.00005574643,0.0002073017,0.00003263734,0.0000357792,0.00005957152,0.0009946416,0.00001900579,0.9952631,0.00004103919,0.002562493,0.0006641619],"study_design_scores_gemma":[0.0008062721,0.0001810231,0.001299964,0.00002190268,0.00007487807,0.0007979626,0.0001989362,0.000008873988,0.9877833,0.0001190755,0.008597597,0.0001102259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950113,0.0003176301,0.0001240335,0.002936741,0.0004626084,0.00004897145,0.0000498589,0.00001317299,0.001035705],"genre_scores_gemma":[0.997248,0.000281901,0.00003381469,0.001401407,0.0002837747,0.00000208035,1.361942e-7,0.00001619612,0.0007327144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00747983,"threshold_uncertainty_score":0.4593795,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2164959062","doi":"10.1099/mic.0.040139-0","title":"Lactobacillus rhamnosus GG attenuates interferon-γ and tumour necrosis factor-α-induced barrier dysfunction and pro-inflammatory signalling","year":2010,"lang":"en","type":"article","venue":"Microbiology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":209,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Foundation of Canada; North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; Crohn's and Colitis Foundation","keywords":"Lactobacillus rhamnosus; Barrier function; Tumor necrosis factor alpha; Chemokine; Tight junction; Intestinal epithelium; Cytokine; Proinflammatory cytokine; Biology; Inflammation; Microbiology; Immunology; Probiotic; Epithelium; Cell biology","retraction":null,"screen_n_in":null,"score":{"opus":0.02177376206685239,"gpt":0.2321271476743795,"spread":0.2103533856075271,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122389,0.0002600243,0.0002877501,0.0001100344,0.0003642757,0.0000744405,0.000115699,0.0002318649,0.0001254103],"category_scores_gemma":[0.0002255173,0.0002095194,0.00004574453,0.00009564037,0.0003764735,0.0001508756,0.0001776433,0.000469592,0.00003109636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001736283,"about_ca_system_score_gemma":0.00002725397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002288698,"about_ca_topic_score_gemma":0.0001161224,"domain_scores_codex":[0.9986403,0.00009440238,0.0002585943,0.0006038023,0.00004739418,0.0003555315],"domain_scores_gemma":[0.9993542,0.000196238,0.0001139214,0.0001650783,0.00005916674,0.0001114415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008035846,0.000007270209,0.007023903,0.0000162124,0.00001592611,0.000005753448,0.0005386823,2.512521e-7,0.9894144,0.0001085543,0.0001777344,0.002610969],"study_design_scores_gemma":[0.0006326078,0.0002391488,0.00962052,0.00001065373,0.00002375701,0.0002767287,0.0001501428,0.0000206425,0.9793179,0.0002098482,0.009199897,0.0002981661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973524,0.000111384,0.00009408603,0.0003092562,0.00152187,0.0002187652,0.00005071036,0.000103472,0.0002380165],"genre_scores_gemma":[0.9988431,0.00003920324,0.00006042156,0.0005974748,0.0001638421,0.00001987605,0.000005038328,0.00002110762,0.0002498908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0100965,"threshold_uncertainty_score":0.8543954,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2041787605","doi":"10.1083/jcb.200309134","title":"Sinuous is a <i>Drosophila</i> claudin required for septate junction organization and epithelial tube size control","year":2004,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":206,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Septate junctions; Biology; Claudin; Paracellular transport; Tight junction; Septate; Vertebrate; Anatomy; Cell junction; Insect; Cell biology; Gene; Genetics; Botany","retraction":null,"screen_n_in":null,"score":{"opus":0.01364391863173008,"gpt":0.2339733169538286,"spread":0.2203293983220985,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002644561,0.0001060541,0.0002166924,0.0000395984,0.0002552225,0.00001631857,0.0001118994,0.00007587104,0.00002269909],"category_scores_gemma":[0.0006018936,0.00006249605,0.00005204503,0.0001491821,0.0001919084,0.00008950406,0.0000233738,0.0001302451,0.000005076182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002651276,"about_ca_system_score_gemma":0.00004969205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003522929,"about_ca_topic_score_gemma":0.000001406563,"domain_scores_codex":[0.9992543,0.0001110802,0.0002856921,0.0001193801,0.00007609926,0.00015348],"domain_scores_gemma":[0.9989294,0.000428101,0.000314183,0.00008766611,0.0001974943,0.00004311152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000422354,0.00001390785,0.00005121637,0.000005060104,0.00001428525,0.000001618212,0.0005948256,0.00005349225,0.9977446,0.000282964,0.0002957597,0.0005199561],"study_design_scores_gemma":[0.003807534,0.001063645,0.0003572434,0.000006087971,0.0001415401,0.0003603121,0.0001025246,0.00001777454,0.9635738,0.0197494,0.0107113,0.0001089021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796585,0.0003055026,0.01333256,0.004667814,0.001496182,0.0002209185,0.00003526127,0.00001773669,0.0002655262],"genre_scores_gemma":[0.994862,0.0005497631,0.0001217805,0.003933405,0.0003823545,0.000001423094,4.432125e-7,0.0000106283,0.0001382156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03417083,"threshold_uncertainty_score":0.2548515,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1985474890","doi":"10.1523/jneurosci.1338-12.2013","title":"Retinoic Acid Induces Blood–Brain Barrier Development","year":2013,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":204,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Blood–brain barrier; Retinoic acid; Cell biology; Biology; Human brain; Neuroscience; Central nervous system; Cell culture; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.03796832454151427,"gpt":0.2603269282180924,"spread":0.2223586036765782,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000312751,0.0001698421,0.0002324268,0.0002038671,0.0004185755,0.0001851947,0.0005973398,0.00004844445,0.0001206334],"category_scores_gemma":[0.002341809,0.00011985,0.00008247495,0.0005726708,0.0003202876,0.0008303073,0.0001427558,0.0003636983,0.00004845662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002024207,"about_ca_system_score_gemma":0.0001692387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001471038,"about_ca_topic_score_gemma":4.526877e-7,"domain_scores_codex":[0.9979556,0.0001132525,0.0005287879,0.0003157647,0.0007385387,0.0003480398],"domain_scores_gemma":[0.9988278,0.0001634587,0.000420884,0.0001860026,0.0001631057,0.0002387119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006885537,0.00002692505,0.0005727789,0.000003897755,0.000001779721,0.00004023094,0.0003991326,0.000003862535,0.9927735,0.00009396115,0.003002801,0.003074293],"study_design_scores_gemma":[0.0003027661,0.0002369577,0.03870165,0.00001770013,0.000009511538,0.000723417,0.00009742104,0.00001850526,0.9130738,0.0003649308,0.04628582,0.0001674654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940331,0.00008755075,0.0003592405,0.00198017,0.002029596,0.0001065435,0.000001263957,0.00002531879,0.001377236],"genre_scores_gemma":[0.9910023,0.00003782403,0.0006366592,0.007183603,0.0001702773,0.000005472462,2.880123e-8,0.00001064548,0.000953252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0796996,"threshold_uncertainty_score":0.4887341,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2483981362","doi":"10.1523/jneurosci.0587-16.2016","title":"Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery","year":2016,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":204,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"National Institute of Neurological Disorders and Stroke; European Commission; National Institutes of Health; BrainsWay; Nova Scotia Health Research Foundation; Israel Science Foundation","keywords":"Neuroprotection; Blood–brain barrier; Glutamate receptor; Neuroscience; Drug; Pharmacology; Drug delivery; Medicine; Psychology; Central nervous system; Chemistry; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.03404094558252221,"gpt":0.272569617107737,"spread":0.2385286715252148,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003611079,0.0001354517,0.0001875982,0.0001779811,0.0004922141,0.0001023381,0.0003069215,0.00003325934,0.000006034768],"category_scores_gemma":[0.00408975,0.00008412314,0.00007824077,0.0003764455,0.0003415383,0.0007008165,0.00009474916,0.0001369321,0.000002189189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001614509,"about_ca_system_score_gemma":0.0000785917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001674697,"about_ca_topic_score_gemma":0.000001455346,"domain_scores_codex":[0.998667,0.0001010079,0.0003734345,0.000344589,0.0002368324,0.0002771564],"domain_scores_gemma":[0.9983006,0.0007943768,0.0003696773,0.0001697434,0.0001747666,0.0001908483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005082986,0.00001579324,0.001255677,0.000004616904,0.000001634287,0.000006436509,0.00006861555,0.000002403465,0.9935846,0.0002999316,0.001123367,0.003586116],"study_design_scores_gemma":[0.00312176,0.001366733,0.1664227,0.0000769897,0.00009087506,0.002611344,0.0000785077,0.0001598052,0.6911952,0.005119284,0.1292734,0.0004834675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786789,0.0000656495,0.006909684,0.01267775,0.001235187,0.0002557873,0.00004650555,0.00003525319,0.00009529749],"genre_scores_gemma":[0.9958763,0.0002080045,0.0001770105,0.003163196,0.0001407611,0.00001358945,5.463026e-8,0.00001357019,0.0004075123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3023894,"threshold_uncertainty_score":0.4896109,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3041523647","doi":"10.1053/j.gastro.2020.07.003","title":"High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":199,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"European Research Council; Ministry of Science and Technology, Israel; Israel Science Foundation; Sun Yat-sen University; Wellcome Trust; Deutsches Krebsforschungszentrum; Garvan Institute of Medical Research; Canadian Institute for Advanced Research; Leona M. and Harry B. Helmsley Charitable Trust; Bill and Melinda Gates Foundation; Howard Hughes Medical Institute","keywords":"Tight junction; Barrier function; Cell biology; Biology; Intestinal epithelium; Lipopolysaccharide; Intestinal mucosa; Immune system; Tumor necrosis factor alpha; Inflammation; Gut flora; Chemistry; Epithelium; Immunology; Internal medicine; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.01768268055455093,"gpt":0.2198429880619993,"spread":0.2021603075074484,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005431789,0.0001486599,0.0002665672,0.00006064917,0.0001118122,0.00001882097,0.000119522,0.00005455053,0.0001078534],"category_scores_gemma":[0.0002053445,0.0001326868,0.00005013379,0.0001227466,0.0004708197,0.0001196737,0.0001983156,0.0001489526,0.00001301899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007048208,"about_ca_system_score_gemma":0.000008302964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002360911,"about_ca_topic_score_gemma":0.00001982884,"domain_scores_codex":[0.9988906,0.00009711456,0.0002630755,0.0004103048,0.0001031591,0.0002357743],"domain_scores_gemma":[0.9995269,0.00005076966,0.000134873,0.0001471178,0.00004626641,0.00009406062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009288714,0.00001353695,0.05985848,0.00002977128,0.00003558902,0.000007927243,0.000384646,0.000007873173,0.93267,0.0007000186,0.005054621,0.0003086652],"study_design_scores_gemma":[0.003009846,0.00406225,0.6800418,0.00003618887,0.0001979301,0.000369084,0.0005987165,0.0001136464,0.3031637,0.0009732752,0.00713089,0.0003026146],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927634,0.00005046392,0.004173411,0.002147123,0.0005807642,0.0001023114,0.00004876044,0.00005391301,0.00007987397],"genre_scores_gemma":[0.9953676,0.00001836414,0.0003078066,0.004077853,0.0001462323,0.00000422671,0.00000352278,0.00001162483,0.00006278973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6295063,"threshold_uncertainty_score":0.5410812,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2509275084","doi":"10.1038/onc.2016.289","title":"The role of claudins in cancer metastasis","year":2016,"lang":"en","type":"review","venue":"Oncogene","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":194,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; Metastasis; Carcinogenesis; Cancer; Claudin; Cancer research; Cancer metastasis; Cell biology; Genetics; Tight junction","retraction":null,"screen_n_in":null,"score":{"opus":0.0840122545481275,"gpt":0.3761593174876983,"spread":0.2921470629395708,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338801,0.0001937111,0.0007472507,0.00007855469,0.0001010475,0.00001205859,0.0003020376,0.00009019727,0.0001402395],"category_scores_gemma":[0.0001559102,0.00008895738,0.0002343314,0.0003636105,0.0001386454,0.00002993585,0.0001136912,0.0001424759,0.00006870308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000635039,"about_ca_system_score_gemma":0.0001617767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002707116,"about_ca_topic_score_gemma":0.0001133161,"domain_scores_codex":[0.9987934,0.0001617537,0.0003685486,0.000288815,0.0001833391,0.0002041582],"domain_scores_gemma":[0.9989466,0.0004090549,0.0002776214,0.0003104613,0.0000242104,0.00003204897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002777203,0.00000497626,0.000003211086,0.0002063919,0.00003004682,0.000001457282,0.00001869397,3.773746e-8,0.0002751371,0.0006967924,0.0003894019,0.9983711],"study_design_scores_gemma":[0.00005687985,0.00001369153,0.000001027638,0.0008010995,0.000113807,0.000005598443,0.000009776493,8.809136e-8,0.002394753,0.0002773033,0.9962251,0.0001008723],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004142275,0.9890843,0.000003475848,0.00004586407,0.0005857095,0.0002046473,0.0001994775,0.000008656276,0.009863716],"genre_scores_gemma":[0.00009074411,0.9981481,0.000007382654,0.00004334731,0.0001567538,0.0001004354,5.568283e-7,0.00001925711,0.00143335],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9982702,"threshold_uncertainty_score":0.3627577,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2120786836","doi":"10.1242/jcs.113.1.45","title":"Analysis of tight junctions during neutrophil transendothelial migration","year":2000,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":191,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Biology; Tight junction; Cell biology","retraction":null,"screen_n_in":null,"score":{"opus":0.0118520687759838,"gpt":0.2342696492998839,"spread":0.2224175805239001,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226632,0.00007385965,0.0002071891,0.0005056193,0.0003105524,0.00003790414,0.000251221,0.00002086575,0.0004566268],"category_scores_gemma":[0.00005517663,0.00005351943,0.0001787074,0.002405114,0.0003655126,0.0004328581,0.000009565048,0.0001192433,0.000005577009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002664855,"about_ca_system_score_gemma":0.00008288401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007279983,"about_ca_topic_score_gemma":0.00001344678,"domain_scores_codex":[0.9987289,0.00003703349,0.0003640505,0.000159479,0.0005566825,0.0001538063],"domain_scores_gemma":[0.9993739,0.00004702249,0.000234123,0.0001273545,0.0001324639,0.00008516982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005878944,0.00003064718,0.0009315332,0.000003238604,0.00001505936,0.000005400622,0.0005993714,0.002212437,0.9951842,0.00004480503,0.00004108255,0.0008734585],"study_design_scores_gemma":[0.0003393004,0.0001209055,0.05864875,0.00000561938,0.0002776717,0.00004661859,0.00008197745,0.0005506998,0.9365356,0.00007446799,0.003238325,0.00008005402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938025,0.00004241955,0.0003670063,0.0002908237,0.0004356582,0.00002940231,0.000005550982,0.000006365698,0.005020222],"genre_scores_gemma":[0.9983717,0.0002338119,0.0001345567,0.00008364115,0.00009054779,4.22742e-7,4.780282e-8,0.000002745127,0.001082539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05864857,"threshold_uncertainty_score":0.4999743,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3044994694","doi":"10.1186/s12987-020-00209-0","title":"Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human","year":2020,"lang":"en","type":"article","venue":"Fluids and Barriers of the CNS","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":189,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Transcytosis; Receptor; Insulin-like growth factor 1 receptor; Transferrin receptor; Blood–brain barrier; Biology; Human brain; LRP1; LDL receptor; Cell biology; Endocrinology; Endocytosis; Neuroscience; Biochemistry; Lipoprotein; Central nervous system; Growth factor","retraction":null,"screen_n_in":null,"score":{"opus":0.0134867520454187,"gpt":0.2263161090649517,"spread":0.212829357019533,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715946,0.0001573358,0.0003493676,0.00002742209,0.0002921129,0.0000210647,0.0002473376,0.00007626333,0.00006876233],"category_scores_gemma":[0.001058163,0.00007739112,0.00007694535,0.0002059599,0.001170827,0.00007524301,0.0001992493,0.000183684,4.729598e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005990538,"about_ca_system_score_gemma":0.00002036541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006146351,"about_ca_topic_score_gemma":0.00001982153,"domain_scores_codex":[0.998669,0.0003538861,0.0003545861,0.0002544544,0.0002192371,0.000148823],"domain_scores_gemma":[0.9991716,0.0003758135,0.0001751034,0.0001767343,0.00002688248,0.00007391248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001144098,0.000007255963,0.01207985,0.00006001027,0.00001251958,8.132184e-8,0.01925129,0.000001668761,0.9659684,0.0001965778,0.001973402,0.0003345597],"study_design_scores_gemma":[0.001671241,0.0000985517,0.00645206,0.00006580805,0.00002641629,0.000001110421,0.003101358,0.0000884211,0.9870552,0.0001744802,0.001152863,0.0001124741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930829,0.0004903768,0.00001947159,0.005815896,0.0001771115,0.0002524954,0.0001048215,0.000009447849,0.00004742372],"genre_scores_gemma":[0.9989756,0.0002951757,0.00001977496,0.0005728035,0.00005061492,0.000008041873,0.000001874216,0.00001115605,0.00006495057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02108685,"threshold_uncertainty_score":0.431396,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2805982252","doi":"10.1093/brain/awy131","title":"The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics","year":2018,"lang":"en","type":"review","venue":"Brain","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Multiple Sclerosis Society; Canada Research Chairs; Multiple Sclerosis Society of Canada; Hotchkiss Brain Institute; Alberta Innovates; University of Calgary","keywords":"Multiple sclerosis; Microbiome; Blood–brain barrier; Intestinal Microbiome; Tight junction; Inflammatory bowel disease; Pathophysiology; Immune system; Gastrointestinal tract; Intestinal permeability; Disease; Immunology; Biology; Medicine; Intestinal mucosa; Neuroscience; Bioinformatics; Central nervous system; Pathology; Cell biology; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.2033938061915519,"gpt":0.3546428987778303,"spread":0.1512490925862785,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815563,0.0001915962,0.0004071841,0.00005480608,0.0004651995,0.00004606521,0.0002236651,0.000114796,0.00000197653],"category_scores_gemma":[0.001351578,0.0001119799,0.0001115792,0.0002010476,0.0003935029,0.0000286535,0.0001058281,0.0001730861,0.000006856919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001871126,"about_ca_system_score_gemma":0.00006838555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002029169,"about_ca_topic_score_gemma":0.00002969602,"domain_scores_codex":[0.9988862,0.0001767496,0.0002841421,0.0003870995,0.00004256767,0.0002232772],"domain_scores_gemma":[0.9962098,0.003295119,0.0001424713,0.0002847313,0.00003419364,0.00003365593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008074204,0.000005738678,0.00001535669,0.0002565658,0.000010668,1.366321e-7,0.00007693674,1.845009e-8,0.0003803395,0.001757459,0.002307339,0.9951814],"study_design_scores_gemma":[0.0001269269,0.00005706457,0.0002896541,0.0003299871,0.00004542408,0.00001095859,0.00001693762,0.000006699172,0.00001291936,0.00415364,0.9948277,0.0001220255],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002710027,0.9975604,0.0002873185,0.0007215632,0.0003492156,0.0007831198,0.0001408333,0.00002768186,0.0001027989],"genre_scores_gemma":[0.0001841227,0.9972001,0.0001327431,0.001391221,0.0002026553,0.000647179,0.000004991272,0.00002308844,0.0002138398],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9950594,"threshold_uncertainty_score":0.4566409,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1982252520","doi":"10.1038/labinvest.3700281","title":"Mouse syngenic in vitro blood–brain barrier model: a new tool to examine inflammatory events in cerebral endothelium","year":2005,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Armand Frappier Museum","funders":"Centre National de la Recherche Scientifique; University of Bern","keywords":"Endothelium; Occludin; Blood–brain barrier; In vivo; Cell biology; Endothelial stem cell; Biology; Cell adhesion molecule; Tight junction; Inflammation; Cell adhesion; Immunology; Pathology; In vitro; Cell; Central nervous system; Medicine; Neuroscience; Biochemistry; Endocrinology","retraction":null,"screen_n_in":null,"score":{"opus":0.01788814003257768,"gpt":0.2339216885007523,"spread":0.2160335484681746,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002953938,0.0002650048,0.0002634687,0.000372305,0.00009631975,0.00003242037,0.0002191024,0.0001363752,0.00004049289],"category_scores_gemma":[0.001051698,0.0002739818,0.00003749504,0.000976664,0.00008219865,0.0006640634,0.00008687764,0.0002995013,0.00007773114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511852,"about_ca_system_score_gemma":0.0003405516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003917718,"about_ca_topic_score_gemma":0.000470303,"domain_scores_codex":[0.9979294,0.0002141794,0.000519445,0.0005733219,0.0003601214,0.0004035555],"domain_scores_gemma":[0.9991137,0.0001007393,0.0001177104,0.0003595236,0.00005648457,0.0002518924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006946695,0.00002411708,0.00630595,0.00001494325,0.000005227742,0.000005677144,0.002593597,0.004097881,0.984773,0.0005668327,0.0009015067,0.0006417864],"study_design_scores_gemma":[0.001494489,0.00004455764,0.009859825,0.00002686326,0.00001183887,0.000002940307,0.0000914612,0.003034591,0.9808283,0.001053963,0.003186853,0.00036428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971792,0.00006447183,0.00014624,0.001626983,0.0001979184,0.0004736321,0.00006210844,0.0001223274,0.0001271468],"genre_scores_gemma":[0.9856108,0.000007609814,0.001562666,0.01137765,0.0002435775,0.0001032075,0.000007185531,0.00003887589,0.001048357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0115683,"threshold_uncertainty_score":0.9999712,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2058032884","doi":"10.1186/1744-8069-6-74","title":"Peripheral Nerve Injury and TRPV1-Expressing Primary Afferent C-Fibers Cause Opening of the Blood-Brain Barrier","year":2010,"lang":"en","type":"article","venue":"Molecular Pain","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":183,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Krembil Foundation; Ontario Neurotrauma Foundation","keywords":"Evans Blue; Extravasation; Medicine; Blood–brain barrier; Anesthesia; Peripheral nerve injury; Sciatic nerve; Vascular permeability; Nerve injury; Chemistry; Neuroscience; Central nervous system; Pathology; Endocrinology; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.01028698568779828,"gpt":0.2336328270001965,"spread":0.2233458413123982,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000434912,0.0001692719,0.0001993782,0.00004443889,0.0002811576,0.00006932211,0.0002007376,0.0000827987,0.00004402908],"category_scores_gemma":[0.0007495432,0.0001190021,0.00009167524,0.0001681081,0.0003185189,0.00009448671,0.0002492286,0.000345931,5.780053e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009105664,"about_ca_system_score_gemma":0.00004244089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001708449,"about_ca_topic_score_gemma":0.000009859633,"domain_scores_codex":[0.9985359,0.000432995,0.0002013713,0.0003408776,0.0002612589,0.0002275641],"domain_scores_gemma":[0.9992591,0.0001568933,0.0001048648,0.0003688815,0.0000263149,0.00008390189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002001644,0.00001200196,0.002498719,0.00001895769,0.00001784457,0.00001699798,0.0007384645,0.000005901563,0.9919239,0.00055342,0.0003935649,0.003800239],"study_design_scores_gemma":[0.0004625236,0.0000812679,0.007944476,0.00003322962,0.00005051969,0.0000331185,0.0001276548,0.0001471297,0.9840167,0.0003726947,0.006510627,0.0002200784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964277,0.0001198242,0.001035188,0.0006261088,0.0004116367,0.0001922012,0.00001277011,0.00003030818,0.00114424],"genre_scores_gemma":[0.99573,0.000003879908,0.0004494147,0.003325792,0.00004692138,0.0000148185,8.293004e-7,0.00002164646,0.0004066418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007907191,"threshold_uncertainty_score":0.4852764,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2153571309","doi":"10.1208/s12248-008-9018-7","title":"Recent Advances in Blood–Brain Barrier Disruption as a CNS Delivery Strategy","year":2008,"lang":"en","type":"review","venue":"The AAPS Journal","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":183,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Blood–brain barrier; Neuroscience; Medicine; Biology; Central nervous system","retraction":null,"screen_n_in":null,"score":{"opus":0.06637013819628886,"gpt":0.3430960738497221,"spread":0.2767259356534332,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003415444,0.0004100331,0.000885319,0.0002260704,0.0006926928,0.0001326169,0.0005392343,0.0001664184,0.000334318],"category_scores_gemma":[0.0005645843,0.0002279364,0.000358352,0.0006133718,0.000249989,0.0003813827,0.0001165679,0.001492878,0.0001151134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009492813,"about_ca_system_score_gemma":0.0003616565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003537717,"about_ca_topic_score_gemma":0.00001719672,"domain_scores_codex":[0.9971558,0.0008020063,0.00072725,0.0003930458,0.0004902835,0.0004315608],"domain_scores_gemma":[0.9984483,0.0004717585,0.0005593069,0.0003158688,0.00006530082,0.0001394832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002052702,0.00002272234,0.00000365879,0.000146229,0.00003174041,0.0002289546,0.0002039826,0.00001161548,0.0000223213,0.0002126062,0.001986389,0.9971092],"study_design_scores_gemma":[0.0002457753,0.0001137062,0.00001063259,0.0009441496,0.0001536605,0.008531679,0.00009263235,9.32206e-7,0.00001618985,0.001255589,0.988385,0.0002500877],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002003826,0.9927513,0.00001382678,0.0002159011,0.001237774,0.0002966872,0.00002639198,0.00002586016,0.005231871],"genre_scores_gemma":[0.0001154732,0.9975236,0.000008518909,0.0005699181,0.0007761716,0.00002663413,0.000002677957,0.00003504772,0.0009419583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9968592,"threshold_uncertainty_score":0.9294978,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3003353139","doi":"10.1073/pnas.1912012117","title":"Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":180,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Heart, Lung, and Blood Institute; Cardiovascular Institute of Philadelphia; National Institute of Mental Health; American Heart Association","keywords":"Nanocarriers; Blood–brain barrier; Cerebral circulation; Targeted drug delivery; Transcytosis; Nanomedicine; Pharmacology; Inflammation; Cancer research; Medicine; Drug; Chemistry; Receptor; Central nervous system; Immunology; Internal medicine; Nanotechnology; Materials science; Endocytosis","retraction":null,"screen_n_in":null,"score":{"opus":0.02743592530858602,"gpt":0.2972959514550886,"spread":0.2698600261465026,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0008019452,0.0001150827,0.00021295,0.00009937676,0.0003256621,0.00001766855,0.0008738161,0.00005530434,0.00001810701],"category_scores_gemma":[0.008816951,0.00006154396,0.00007892207,0.002239753,0.0007419395,0.0002520981,0.0002804679,0.0002407771,0.000001420824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000122894,"about_ca_system_score_gemma":0.00003821315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003067276,"about_ca_topic_score_gemma":8.484457e-8,"domain_scores_codex":[0.9978351,0.00001637338,0.000347282,0.0003601871,0.001258279,0.0001828019],"domain_scores_gemma":[0.998926,0.0003161292,0.0003245082,0.0000115494,0.000340484,0.00008134334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003219592,0.000007123132,0.001704569,0.00003072098,0.00001371571,4.375459e-9,0.003492233,0.000114754,0.981223,0.008338443,0.0048739,0.0001693101],"study_design_scores_gemma":[0.0001038379,0.0001298421,0.01559725,0.0000410085,0.00001423549,0.000001971252,0.0005086644,0.00008441569,0.977275,0.003788734,0.002382347,0.00007270924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9295758,0.00007792349,0.000008199204,0.06612827,0.00005477186,0.0003769979,0.00002163885,0.00001521267,0.003741167],"genre_scores_gemma":[0.9869443,0.000005635827,0.0005645262,0.01213419,0.0001919483,0.00001496464,2.634797e-8,0.000004267814,0.0001401547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05736847,"threshold_uncertainty_score":0.9995322,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2137803034","doi":"10.1111/j.1462-5822.2005.00656.x","title":"Attaching and effacing pathogen-induced tight junction disruption in vivo","year":2005,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":179,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Tight junction; Biology; Pathogen; Claudin; Microbiology; Cell biology; Septate junctions; Barrier function; Cell junction; Transmembrane protein; Epithelium; Effector; Intestinal epithelium; In vivo; Virulence; Intracellular; Gap junction; Cell; Receptor; Genetics; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.01912229785429162,"gpt":0.2395750946880387,"spread":0.2204527968337471,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133773,0.0001347721,0.000169949,0.0001136718,0.0001773256,0.00001938674,0.0000611968,0.0001212765,0.00006408991],"category_scores_gemma":[0.0000639463,0.0001170222,0.00003390069,0.0001337582,0.00007547467,0.0001112612,0.00006756817,0.0001870916,0.00003594307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004080475,"about_ca_system_score_gemma":0.00000863097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001113306,"about_ca_topic_score_gemma":0.00004623524,"domain_scores_codex":[0.9990061,0.0001367958,0.0001999064,0.0003927378,0.00002877874,0.0002356867],"domain_scores_gemma":[0.9997024,0.00006124801,0.00006333616,0.0001262486,0.0000112584,0.00003552742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001712239,0.0000108572,0.001118146,0.000006403852,0.000002504952,0.000007035464,0.000411474,0.00001012846,0.9930317,0.000248902,0.00008978673,0.005045913],"study_design_scores_gemma":[0.000421345,0.00004772635,0.0007565896,0.000008321203,0.00000850492,0.0001100838,0.00009154433,0.0001090046,0.9541528,0.00006502359,0.04407879,0.0001503114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965715,0.0003191158,0.001161571,0.0002503462,0.0006545784,0.0001233788,0.000008456705,0.00004806113,0.0008629474],"genre_scores_gemma":[0.9988366,0.00004719939,0.0001058663,0.0005359477,0.0001617155,0.000007083279,0.000005661031,0.00001026918,0.0002896042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04398901,"threshold_uncertainty_score":0.4772026,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2065318944","doi":"10.1016/j.brainresrev.2005.07.004","title":"The critical component to establish in vitro BBB model: Pericyte","year":2005,"lang":"en","type":"review","venue":"Brain Research Reviews","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":177,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Northern British Columbia; University of British Columbia; St. Paul's Hospital","funders":"","keywords":"Pericyte; Blood–brain barrier; Cell biology; Angiogenesis; Biology; Neuroscience; Endothelial stem cell; Central nervous system; Tight junction; Vascular permeability; Cell type; In vitro; Cell; Cancer research; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.4449099965773489,"gpt":0.5348802790215247,"spread":0.08997028244417582,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006827115,0.0005306451,0.002134746,0.000504743,0.0007876882,0.0004912473,0.001612018,0.0002151282,0.00005175822],"category_scores_gemma":[0.03217228,0.0002993303,0.000573623,0.002388724,0.0006732935,0.0001640064,0.00104104,0.002203429,0.0009486967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003394566,"about_ca_system_score_gemma":0.0003986154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001682884,"about_ca_topic_score_gemma":0.00003554926,"domain_scores_codex":[0.9898416,0.00489038,0.001341298,0.00121452,0.001322468,0.001389746],"domain_scores_gemma":[0.9900462,0.007920923,0.0001419993,0.001306471,0.0001616208,0.0004228019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001647111,0.00002582703,3.682421e-8,0.002146001,0.000004225657,0.0000181944,0.00009902236,0.000001184758,0.00005774347,0.00214911,0.1177009,0.8777813],"study_design_scores_gemma":[0.00006935565,0.00003904456,4.242495e-7,0.002609882,0.00002267809,0.0000235786,0.00001759924,0.0000892656,0.000009942836,0.0002225512,0.996605,0.0002906545],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[4.36157e-7,0.9837664,0.0001635755,0.005443038,0.0003700846,0.003224009,0.00006033328,0.00004118229,0.006930958],"genre_scores_gemma":[0.000006332737,0.9911802,0.0004144341,0.00159508,0.0005224852,0.002003425,0.000006133328,0.00006640542,0.004205535],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8789041,"threshold_uncertainty_score":0.9999459,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1543001415","doi":"10.1155/2015/708306","title":"Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?","year":2015,"lang":"en","type":"review","venue":"Neural Plasticity","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":175,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science","keywords":"Blood–brain barrier; Proinflammatory cytokine; Central nervous system; Inflammation; Neuroscience; Neuroinflammation; Myelin; Multiple sclerosis; Oxidative stress; Medicine; Biology; Immunology; Endocrinology","retraction":null,"screen_n_in":null,"score":{"opus":0.0624091709496349,"gpt":0.3247535046352533,"spread":0.2623443336856184,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007699951,0.0004086408,0.0008142826,0.0002012063,0.0003748956,0.0002104484,0.0003977668,0.0002486441,0.000005908718],"category_scores_gemma":[0.004128092,0.0002188504,0.0001181047,0.000741999,0.000277602,0.0002499237,0.0001757831,0.001130529,0.00000766721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000445642,"about_ca_system_score_gemma":0.00008153672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000618354,"about_ca_topic_score_gemma":0.0001456217,"domain_scores_codex":[0.9967063,0.001317507,0.0006489288,0.0005457486,0.0004268135,0.0003546723],"domain_scores_gemma":[0.9948369,0.004479692,0.000307625,0.0002717029,0.00002646633,0.00007767091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001073494,0.000008703193,0.001082638,0.0007877505,0.00001204006,0.0000178435,0.0007943193,0.00001064002,0.00009742152,0.0002595041,0.0002297762,0.9966886],"study_design_scores_gemma":[0.0003630802,0.00009124508,0.005199694,0.0005873466,0.000222363,0.0000570005,0.00005757796,0.0003109225,0.00002156849,0.0005782637,0.9922069,0.0003040758],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0302081,0.9591816,0.0001583996,0.007772594,0.0005721628,0.001712118,0.0001745968,0.00007755205,0.0001428668],"genre_scores_gemma":[0.07823005,0.9179401,0.00001591967,0.00135194,0.002016185,0.0001917412,0.00006170436,0.00007852603,0.0001138555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9963846,"threshold_uncertainty_score":0.8924462,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}