{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":235,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":235,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"a34c73639718","filters":{"topic":"Bioactive Compounds and Antitumor Agents"}},"results":[{"id":"W2037407093","doi":"10.3390/molecules190914902","title":"1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling","year":2014,"lang":"en","type":"review","venue":"Molecules","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":221,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Juglone; Plumbagin; Oxidative stress; Menadione; Cell biology; Lawsone; Oxidative phosphorylation; Reactive oxygen species; Signal transduction; Chemistry; Pro-oxidant; Redox; Biochemistry; Cell signaling; Biology","authors":[{"name":"Lars‐Oliver Klotz","is_ca":true},{"name":"Xiaoqing Hou","is_ca":true},{"name":"Claus Jacob","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1447821862825263,"gpt":0.4342533037244728,"spread":0.2894711174419465,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002050028,0.0006403664,0.000748172,0.001558973,0.0003295917,0.0007137851,0.0005397844,0.0006319336,0.003471431],"category_scores_gemma":[0.0001545002,0.0002135326,0.0003053734,0.00130375,0.0003622053,0.0009198766,0.0005640188,0.0009741376,0.001772748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000429481,"about_ca_system_score_gemma":0.0006214775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006618295,"about_ca_topic_score_gemma":0.001313455,"domain_scores_codex":[0.9999267,0.000009787246,0.000007919637,0.00001517727,0.00002896004,0.00001147342],"domain_scores_gemma":[0.9999284,0.00001982182,0.000014292,0.000003168024,0.00002387097,0.00001046004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009012035,0.0001500802,0.0002604508,0.02535334,0.0001022116,0.0004500709,0.0001657572,0.0006590809,0.02886686,0.008884362,0.01547041,0.9195473],"study_design_scores_gemma":[0.00001198732,0.0001072061,0.000889695,0.001082908,0.00006042807,0.001348834,0.00008399926,0.0000970691,0.004538065,0.003072118,0.9886911,0.00001646021],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007073748,0.9966575,0.0003565972,0.000213677,0.0001143797,0.00000891405,0.00003208732,0.00001457213,0.001894951],"genre_scores_gemma":[0.0038385,0.9940777,0.0002924282,0.00009450069,0.00008788269,0.000008645064,0.00004815166,0.000001800682,0.001550325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003471431,"threshold_uncertainty_score":0.01161313,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2787038964","doi":"10.1016/s2468-1253(18)30009-8","title":"Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":168,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University; University of Alberta; University of Toronto; Ottawa Hospital; BC Cancer Agency; Princess Margaret Cancer Centre; University of Ottawa; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Boston Biomedical; Cancer Research Institute","keywords":"Placebo; Medicine; Colorectal cancer; Refractory (planetary science); Internal medicine; Oncology; Clinical trial; Cancer; Alternative medicine; Biology; Pathology","authors":[{"name":"Derek J. Jonker","is_ca":true},{"name":"Louise Nott","is_ca":false},{"name":"Takayuki Yoshino","is_ca":false},{"name":"Sharlene Gill","is_ca":true},{"name":"Jeremy Shapiro","is_ca":false},{"name":"Atsushi Ohtsu","is_ca":false},{"name":"John Zalcberg","is_ca":false},{"name":"Michael M. Vickers","is_ca":true},{"name":"Alice C. Wei","is_ca":true},{"name":"Yuan Gao","is_ca":false},{"name":"Niall C. Tebbutt","is_ca":false},{"name":"Ben Markman","is_ca":false},{"name":"Timothy Price","is_ca":false},{"name":"Taito Esaki","is_ca":false},{"name":"Sheryl Koski","is_ca":true},{"name":"Matthew Hitron","is_ca":false},{"name":"Wěi Li","is_ca":false},{"name":"Youzhi Li","is_ca":false},{"name":"Nadine M Magoski","is_ca":true},{"name":"Chiang J. Li","is_ca":false},{"name":"John Simes","is_ca":false},{"name":"Dongsheng Tu","is_ca":true},{"name":"Christopher J. O’Callaghan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1117958393733001,"gpt":0.4385704081685156,"spread":0.3267745687952155,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001017174,0.001465919,0.002588803,0.0003041664,0.0002926211,0.0008358183,0.0006855798,0.001637672,0.0072521],"category_scores_gemma":[0.001456036,0.0004731797,0.001749994,0.0003519195,0.0008361827,0.0009569628,0.0003470975,0.002553568,0.0009880518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007221279,"about_ca_system_score_gemma":0.0006603225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146229,"about_ca_topic_score_gemma":0.00276493,"domain_scores_codex":[0.9996557,0.0001830109,0.00001986153,0.00005681939,0.00002437717,0.00006011525],"domain_scores_gemma":[0.9994168,0.0002290069,0.0001078111,0.00004051304,0.00003500075,0.0001708689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9841164,0.0009351952,0.0002106676,0.000866456,0.0009971963,0.00004366573,0.00003182598,0.0001669883,0.001655468,0.00008896465,0.0007534149,0.01013385],"study_design_scores_gemma":[0.9680471,0.02881732,0.001126102,0.0000675374,0.0005761251,0.00003621534,0.00002936738,0.0001930582,0.0001639991,0.0002334637,0.0006963002,0.00001359895],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9591866,0.02904604,0.0006925883,0.001933917,0.001937417,0.002583736,0.001336639,0.0001632375,0.003119724],"genre_scores_gemma":[0.9796798,0.009376646,0.00103161,0.00157508,0.0006074824,0.002234167,0.0009565004,0.00002505487,0.004513668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0072521,"threshold_uncertainty_score":0.0242607,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2981799902","doi":"10.3390/cancers11111646","title":"STAT3: An Emerging Therapeutic Target for Hepatocellular Carcinoma","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":135,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Health and Medical Research Fund; Terry Fox Foundation","keywords":"STAT3; Hepatocellular carcinoma; Medicine; STAT protein; Cancer research; Targeted therapy; Clinical trial; Transcription factor; Metastasis; Cancer; Oncology; Internal medicine; Biology; Signal transduction; Gene","authors":[{"name":"Carol Lee","is_ca":false},{"name":"ST Cheung","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3763264120059471,"gpt":0.5037783466143937,"spread":0.1274519346084466,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641028,0.0005222674,0.0006538779,0.001309047,0.0001760523,0.0004989114,0.0003871979,0.0006244727,0.003731197],"category_scores_gemma":[0.0002098577,0.0001361355,0.0004285259,0.0009771292,0.0002193998,0.0005808649,0.0003967026,0.001370099,0.001340885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820793,"about_ca_system_score_gemma":0.0006634396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006622333,"about_ca_topic_score_gemma":0.001812733,"domain_scores_codex":[0.9999197,0.00001311519,0.00001064447,0.00001401149,0.00003086024,0.00001179116],"domain_scores_gemma":[0.9999231,0.00003106219,0.0000118545,0.00000222596,0.00002283874,0.000008927416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001074142,0.00008564658,0.0002011969,0.01312314,0.00008297092,0.0001843522,0.00004694429,0.0004294109,0.005025273,0.003473625,0.02509504,0.952145],"study_design_scores_gemma":[0.00003021596,0.0001800275,0.0009302614,0.001855742,0.0001346417,0.00100818,0.00004264536,0.0001905741,0.001360793,0.001889948,0.9923595,0.00001752754],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003222632,0.9979233,0.0001337791,0.0003243753,0.0001763331,0.000004532744,0.00003691875,0.00001103394,0.00106755],"genre_scores_gemma":[0.001682864,0.9968151,0.0001460648,0.0002958006,0.0001334018,0.000006605465,0.00007666658,0.000001698345,0.0008416416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003731197,"threshold_uncertainty_score":0.01248211,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2094761209","doi":"10.1007/s12013-007-0037-2","title":"An Overview of DNA and RNA Bindings to Antioxidant Flavonoids","year":2007,"lang":"en","type":"article","venue":"Cell Biochemistry and Biophysics","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":110,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"DNA; Delphinidin; Chemistry; Kaempferol; RNA; Transfer RNA; Stereochemistry; Flavonoid; Quercetin; Biochemistry; Antioxidant; Cyanidin","authors":[{"name":"Charalabos D. Kanakis","is_ca":false},{"name":"Petros Α. Tarantilis","is_ca":false},{"name":"Moschos G. Polissiou","is_ca":false},{"name":"S. Diamantoglou","is_ca":true},{"name":"H.A. Tajmir‐Riahi","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0909659849509268,"gpt":0.4091885814139949,"spread":0.3182225964630681,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003760814,0.0007965169,0.001031173,0.001667921,0.0005841982,0.000727291,0.0006541079,0.0007158663,0.002340481],"category_scores_gemma":[0.0002213567,0.0005148908,0.0006006993,0.001213068,0.0003280544,0.001060371,0.000426434,0.001006316,0.001637111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000981285,"about_ca_system_score_gemma":0.0004520706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000999416,"about_ca_topic_score_gemma":0.001548115,"domain_scores_codex":[0.9998241,0.00003163988,0.00001759977,0.00004446977,0.00004906298,0.00003302173],"domain_scores_gemma":[0.9998726,0.00006474269,0.00001795934,0.000009884171,0.00002093106,0.00001383718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004472158,0.0001791484,0.0005816637,0.007542447,0.0001327762,0.0006648836,0.000226869,0.002253362,0.5836323,0.00663337,0.006142073,0.391564],"study_design_scores_gemma":[0.00002003208,0.0006708982,0.004407861,0.0004758556,0.000206153,0.002317694,0.0002211901,0.001140433,0.3164146,0.005598294,0.6684606,0.00006639711],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0274584,0.9244824,0.02787057,0.0009961401,0.000561238,0.00008953855,0.0005400488,0.0003015417,0.01770018],"genre_scores_gemma":[0.05659619,0.8995661,0.01486132,0.001143276,0.001091672,0.0001696566,0.001333405,0.00005593074,0.02518247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002340481,"threshold_uncertainty_score":0.007829726,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2154353832","doi":"10.1002/ptr.906","title":"Isolation of an antimicrobial compound from <i>Impatiens balsamina</i> L. using bioassay‐guided fractionation","year":2001,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":100,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Carleton University; Western University","funders":"","keywords":"Brine shrimp; Artemia salina; Antimicrobial; Fractionation; Bioassay; Pharmacognosy; Chromatography; Bioactive compound; Impatiens; Biology; Bacteria; Chemistry; Traditional medicine; Botany; Microbiology; Biological activity; Organic chemistry; Toxicity; Biochemistry; In vitro","authors":[{"name":"Xiaolong Yang","is_ca":true},{"name":"D. Kristen Summerhurst","is_ca":true},{"name":"Susan F. Koval","is_ca":true},{"name":"Christine Ficker","is_ca":true},{"name":"Myron L. Smith","is_ca":true},{"name":"Mark A. Bernards","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.4354282630916434,"gpt":0.550773071673836,"spread":0.1153448085821926,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007591793,0.0005973923,0.0003242265,0.000502567,0.0002262082,0.0002058623,0.0001647327,0.0002833415,0.0008853881],"category_scores_gemma":[0.0001450457,0.0001403077,0.0003414212,0.0002846392,0.0001816019,0.0002369934,0.000245933,0.0003750376,0.000346201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001161878,"about_ca_system_score_gemma":0.0001952002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008265639,"about_ca_topic_score_gemma":0.001087788,"domain_scores_codex":[0.9999634,0.000005449898,0.000003711804,0.000008907892,0.000009559644,0.000009009294],"domain_scores_gemma":[0.9999055,0.0000181399,0.00001975008,0.000008940601,0.00002400283,0.00002364844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005278114,0.00001935553,0.0001602045,0.00008029457,0.000006785655,0.00009664778,0.00001282408,0.00003428794,0.9951509,0.00001648505,0.0000287931,0.004340631],"study_design_scores_gemma":[0.00003262869,0.001003674,0.01025794,0.00001807761,0.00006780657,0.00080576,0.00003904286,0.0002572721,0.9819983,0.00006752696,0.005440444,0.00001151954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710039,0.01043801,0.01224141,0.0004583525,0.00008319244,0.0001815658,0.001226929,0.0003030629,0.004063522],"genre_scores_gemma":[0.9803149,0.003428455,0.01123148,0.0003054526,0.00006738754,0.00004717734,0.001589774,0.00003922626,0.002976102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008853881,"threshold_uncertainty_score":0.002961934,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3129058379","doi":"10.1016/j.jep.2021.113896","title":"Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: A review","year":2021,"lang":"en","type":"review","venue":"Journal of Ethnopharmacology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":94,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Ministry of Environment - Saskatchewan","keywords":"Phytochemical; Traditional medicine; Biology; Medicine","authors":[{"name":"Anil Kumar","is_ca":false},{"name":"Sarla Shashni","is_ca":false},{"name":"Pawan Kumar","is_ca":false},{"name":"Deepak Raj Pant","is_ca":false},{"name":"Ashok Singh","is_ca":false},{"name":"Raj Kumar Verma","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.429824795929596,"gpt":0.5431475198763285,"spread":0.1133227239467324,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002269672,0.0007839234,0.001097817,0.003315141,0.0002678549,0.0008190274,0.0005311673,0.0004376564,0.003552813],"category_scores_gemma":[0.0003022063,0.0002732727,0.0005181835,0.002921942,0.0002505862,0.0008874362,0.0005316424,0.000655681,0.0008025775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001819253,"about_ca_system_score_gemma":0.0006116293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001470085,"about_ca_topic_score_gemma":0.003068079,"domain_scores_codex":[0.9999063,0.00001021959,0.00002074549,0.00002511012,0.0000294072,0.000008167501],"domain_scores_gemma":[0.999848,0.00006250065,0.0000455328,0.000004253572,0.00002848544,0.00001114636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002358619,0.0001626331,0.001011819,0.04099362,0.0003012594,0.0004783974,0.0001677307,0.0004108236,0.008429834,0.001253764,0.008397806,0.9381565],"study_design_scores_gemma":[0.00005865816,0.0004086439,0.01246199,0.00765413,0.001554444,0.00467842,0.0003696794,0.000252758,0.003472487,0.001987849,0.9670064,0.00009438473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001027353,0.9973704,0.0001689351,0.0001079938,0.0000738431,0.000007591214,0.00009605016,0.00001125423,0.001136612],"genre_scores_gemma":[0.003297284,0.995436,0.0003329867,0.0001115006,0.00008574445,0.000004190937,0.00009384721,0.000001855653,0.0006366346],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003552813,"threshold_uncertainty_score":0.0118854,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2158182233","doi":"10.1093/toxsci/kfh182","title":"Application of Quantitative Structure-Toxicity Relationships for the Comparison of the Cytotoxicity of 14 p-Benzoquinone Congeners in Primary Cultured Rat Hepatocytes Versus PC12 Cells","year":2004,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":91,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cytotoxicity; Glutathione; Chemistry; Benzoquinone; Reactive oxygen species; Cytotoxic T cell; Hepatocyte; Quinone; Toxicity; Biochemistry; Hydrogen peroxide; In vitro; Enzyme; Organic chemistry","authors":[{"name":"Arno G. Siraki","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2838262276235889,"gpt":0.4576947473018386,"spread":0.1738685196782497,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003400418,0.001628939,0.0008566934,0.00232223,0.0002834147,0.0006619075,0.0007561817,0.0009014296,0.001819968],"category_scores_gemma":[0.004801618,0.0005410977,0.001230089,0.002613632,0.0004923851,0.0008928993,0.0007545983,0.001071054,0.0008432676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006537034,"about_ca_system_score_gemma":0.0004490097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007881002,"about_ca_topic_score_gemma":0.0009921617,"domain_scores_codex":[0.9970891,0.001490664,0.0003143162,0.0002945056,0.0007105556,0.0001009655],"domain_scores_gemma":[0.9941836,0.003244713,0.001043679,0.0004768836,0.0009658944,0.00008524536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008781993,0.0004853245,0.007245877,0.0009311555,0.0002761522,0.0002161038,0.0002712672,0.01222923,0.9484907,0.0007637725,0.0001503461,0.02806186],"study_design_scores_gemma":[0.00005821393,0.006266923,0.02845345,0.00004260843,0.0003308099,0.0007992749,0.0003392446,0.03852675,0.9216025,0.001166937,0.002329198,0.0000840413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7373129,0.007860432,0.2440076,0.0001917109,0.00007989971,0.001043399,0.004110835,0.001138343,0.00425495],"genre_scores_gemma":[0.9016839,0.002731394,0.0888585,0.0001044891,0.00003021594,0.001360306,0.00327922,0.0001016845,0.001850346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003400418,"threshold_uncertainty_score":0.01798332,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2075023632","doi":"10.1002/mc.20199","title":"Targeting NAD(P)H:Quinone Oxidoreductase (NQO1) in Pancreatic Cancer","year":2006,"lang":"en","type":"erratum","venue":"Molecular Carcinogenesis","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":90,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; Foundation of Hope for Research and Treatment of Mental Illness; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Pancreatic cancer; Biology; Clonogenic assay; NAD+ kinase; Pancreatic Intraepithelial Neoplasia; Cancer research; Pancreas; Cell culture; Cancer; Gemcitabine; Cancer cell; Molecular biology; Cell; Internal medicine; Endocrinology; Biochemistry; Enzyme; Medicine","authors":[{"name":"Anne Marie Lewis","is_ca":false},{"name":"Matthew Ough","is_ca":false},{"name":"Juan Du","is_ca":false},{"name":"Ming‐Sound Tsao","is_ca":true},{"name":"Larry W. Oberley","is_ca":false},{"name":"Joseph J. Cullen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06188180249549044,"gpt":0.3802559168254417,"spread":0.3183741143299512,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396496,0.0003919469,0.000389141,0.0004420961,0.0001939274,0.0003566837,0.0003746602,0.0006619295,0.002857113],"category_scores_gemma":[0.0003765501,0.0001191845,0.000111052,0.0004798938,0.0004086561,0.0004546079,0.0001557576,0.0006805446,0.001317138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004073651,"about_ca_system_score_gemma":0.0003129015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006910988,"about_ca_topic_score_gemma":0.001356002,"domain_scores_codex":[0.9999356,0.00001893996,0.000009561303,0.0000116204,0.00001665174,0.00000763866],"domain_scores_gemma":[0.9998827,0.00003984904,0.00002411508,0.000009851278,0.00002628551,0.00001716657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003341616,0.0005406914,0.005695675,0.004236695,0.00006359838,0.008601497,0.0001913415,0.001436224,0.5813087,0.005308376,0.03609595,0.3531797],"study_design_scores_gemma":[0.0003074201,0.002247272,0.01712745,0.0002171804,0.0002182178,0.01765616,0.0001886754,0.001590149,0.3897123,0.001127328,0.5695686,0.00003914766],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.4483944,0.4554592,0.02663907,0.01524875,0.01697422,0.0004542469,0.001440728,0.0009734838,0.03441602],"genre_scores_gemma":[0.5820021,0.3274332,0.03261134,0.002309847,0.002656526,0.0001534828,0.001999464,0.0001116254,0.05072245],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002857113,"threshold_uncertainty_score":0.009558022,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2091801473","doi":"10.1016/j.ijpharm.2007.06.032","title":"Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors","year":2007,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":89,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Ministry of Health and Medical Education","keywords":"Solubilization; Micelle; Chemistry; Pharmacology; Dosage form; Chromatography; Medicine; Organic chemistry; Aqueous solution; Biochemistry","authors":[{"name":"Ommoleila Molavi","is_ca":true},{"name":"Zengshuan Ma","is_ca":true},{"name":"Abdullah Mahmud","is_ca":true},{"name":"Aws Alshamsan","is_ca":true},{"name":"John Samuel","is_ca":true},{"name":"Raymond Lai","is_ca":true},{"name":"Glen S. Kwon","is_ca":false},{"name":"Afsaneh Lavasanifar","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1195586334171882,"gpt":0.4688840952086903,"spread":0.3493254617915021,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789003,0.000259804,0.0001403928,0.0001971314,0.0001298104,0.0001704572,0.000171728,0.0002075559,0.0007270198],"category_scores_gemma":[0.0001693943,0.0001204014,0.0001524091,0.0001329695,0.0001592678,0.0002610004,0.0001525199,0.0004126541,0.0001839501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004791113,"about_ca_system_score_gemma":0.0003073256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001722544,"about_ca_topic_score_gemma":0.002224543,"domain_scores_codex":[0.9999332,0.00001595199,0.000004127169,0.00001218717,0.00001466873,0.00001974073],"domain_scores_gemma":[0.9999466,0.00001133014,0.00001778046,0.000004150244,0.00001040162,0.000009814041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001428426,0.00002168604,0.00003430695,0.00004167734,0.000005011042,0.00001899034,0.00001439693,0.0002611495,0.9968924,0.000124495,0.00005222646,0.002390892],"study_design_scores_gemma":[0.00002866161,0.000238804,0.000268427,0.00000450807,0.00001551884,0.00005560847,0.000006137825,0.001744547,0.9959773,0.00001689836,0.001639785,0.000003803219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868448,0.003665443,0.007623712,0.000179826,0.0000502681,0.00006622221,0.0001005969,0.0001334675,0.00133574],"genre_scores_gemma":[0.9936734,0.001329868,0.003229198,0.00003132767,0.00001179822,0.00003485667,0.00007953776,0.00002685361,0.001583181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722544,"threshold_uncertainty_score":0.003476262,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2110961018","doi":"10.1089/dna.2008.0735","title":"DNA Adducts with Antioxidant Flavonoids: Morin, Apigenin, and Naringin","year":2008,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":89,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Morin; Naringin; Apigenin; DNA; Binding constant; Flavonoid; Polyphenol; Luteolin; Biology; Biochemistry; Fisetin; Chemistry; Antioxidant; Binding site; Chromatography","authors":[{"name":"Shohreh Nafisi","is_ca":false},{"name":"Mehrdad Hashemi","is_ca":false},{"name":"Mehdi Rajabi","is_ca":false},{"name":"Heidar Ali Tajmir-Riahi","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07387883988888011,"gpt":0.3431818375853843,"spread":0.2693029976965042,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978325,0.000405545,0.0002446598,0.000256279,0.0001884338,0.0001753139,0.0002756016,0.0005591564,0.001757873],"category_scores_gemma":[0.0003698064,0.0001451237,0.00021301,0.0001968944,0.0002211697,0.000376352,0.0002017617,0.0003868797,0.000312592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003183788,"about_ca_system_score_gemma":0.0001089179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005359623,"about_ca_topic_score_gemma":0.0005810473,"domain_scores_codex":[0.9998389,0.00003260801,0.000006623569,0.00005740375,0.00004324463,0.00002104777],"domain_scores_gemma":[0.9997569,0.00005881673,0.0001005086,0.0000164126,0.00003946284,0.00002797998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007278129,0.00001164797,0.0003038123,0.00008283412,0.0000150654,0.00001859047,0.00002401366,0.00006014334,0.9980772,0.00004343508,0.00002191219,0.001268553],"study_design_scores_gemma":[0.00001117181,0.0004176993,0.003161897,0.000009541079,0.00002448332,0.0001398889,0.00002317104,0.0004158616,0.9936935,0.00005401174,0.002043648,0.000005021676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804007,0.007739943,0.009801379,0.0001622983,0.00003946042,0.00005724289,0.000211587,0.0001350265,0.001452243],"genre_scores_gemma":[0.9891779,0.001702333,0.00608853,0.0001267412,0.00001847551,0.000048128,0.0003119452,0.00001684892,0.002509045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001757873,"threshold_uncertainty_score":0.005880654,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4242413941","doi":"10.1002/mc.20107","title":"Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer","year":2005,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":83,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; Foundation of Hope for Research and Treatment of Mental Illness; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Pancreatic cancer; Biology; Clonogenic assay; Cancer research; NAD+ kinase; Pancreatic Intraepithelial Neoplasia; Pancreas; Cancer; Cell culture; Cancer cell; Molecular biology; Cell; Endocrinology; Biochemistry; Enzyme","authors":[{"name":"Anne Marie Lewis","is_ca":false},{"name":"Matthew Ough","is_ca":false},{"name":"Marilyn M. Hinkhouse","is_ca":false},{"name":"Ming‐Sound Tsao","is_ca":true},{"name":"Larry W. Oberley","is_ca":false},{"name":"Joseph J. Cullen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07324748171060018,"gpt":0.395115716120495,"spread":0.3218682344098948,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160008,0.0001714472,0.0002274826,0.0001920033,0.0001544257,0.000199272,0.0001748723,0.0002454935,0.0006240907],"category_scores_gemma":[0.0001102681,0.00009068471,0.00008452764,0.0001924294,0.0002289575,0.0001697657,0.0001564404,0.0004186282,0.000142992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242011,"about_ca_system_score_gemma":0.000237752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003868697,"about_ca_topic_score_gemma":0.0009880032,"domain_scores_codex":[0.9999605,0.00001254145,0.00000380157,0.000006983322,0.000007407777,0.000008696996],"domain_scores_gemma":[0.9999444,0.00001205564,0.00001598291,0.000006471829,0.000006570524,0.00001448211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004373416,0.000126474,0.0007999565,0.000143883,0.000006369123,0.0001317642,0.00001547248,0.0001626409,0.9856883,0.0001177517,0.0001177805,0.01225223],"study_design_scores_gemma":[0.0001815357,0.004994282,0.01376205,0.00001771057,0.00008054769,0.001625093,0.00007574119,0.001054845,0.9656345,0.0002315778,0.01233408,0.000007945178],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834262,0.01105742,0.003427903,0.0004544558,0.00003826324,0.00005423148,0.00006668513,0.00006625654,0.001408563],"genre_scores_gemma":[0.9868225,0.008150017,0.003755509,0.00007675894,0.00003146781,0.00002591275,0.0001518723,0.000007621657,0.0009784194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006240907,"threshold_uncertainty_score":0.002087772,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1989526884","doi":"10.1038/sj.onc.1209251","title":"Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":81,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"University of Ottawa","keywords":"Soluble guanylyl cyclase; Biology; Apoptosis; Downregulation and upregulation; Carcinogenesis; Cancer research; Signal transduction; Cyclic guanosine monophosphate; Cell biology; Endocrinology; Cancer; Biochemistry; Nitric oxide; Gene; Guanylate cyclase","authors":[{"name":"Michael Fraser","is_ca":true},{"name":"Sandra L. Chan","is_ca":true},{"name":"Stewart Siu-Wa Chan","is_ca":true},{"name":"Ronald R. Fiscus","is_ca":false},{"name":"Benjamin K. Tsang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07322262851504488,"gpt":0.3953192335258515,"spread":0.3220966050108066,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703671,0.000178082,0.0002569192,0.0003743807,0.000258044,0.0002089761,0.0001480264,0.0002527076,0.001030613],"category_scores_gemma":[0.0002096735,0.0001171977,0.0002193176,0.0002473432,0.0002687835,0.0002152503,0.0001580727,0.000458088,0.0001343252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004313466,"about_ca_system_score_gemma":0.0003661919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003332637,"about_ca_topic_score_gemma":0.00348422,"domain_scores_codex":[0.9998777,0.00003069586,0.000008321095,0.00001299571,0.00002485604,0.00004529016],"domain_scores_gemma":[0.9999257,0.00002567331,0.00001176711,0.00001241549,0.00001032255,0.00001398682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008712506,0.0001421286,0.0009130423,0.00006110134,0.00001167606,0.000426993,0.0001038257,0.0001619288,0.9937516,0.0005016965,0.0002287291,0.002825897],"study_design_scores_gemma":[0.0002169389,0.001449253,0.03691871,0.00001187168,0.0000373438,0.0006944109,0.0002278573,0.002419905,0.9532294,0.0003742829,0.004410748,0.000009284488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954801,0.002530693,0.0004518761,0.0002068961,0.00003483622,0.00001972255,0.0002128494,0.00003119062,0.001031837],"genre_scores_gemma":[0.9978763,0.0006836003,0.0001877606,0.00003095394,0.000007436722,0.00002179403,0.0002366481,0.000002723657,0.0009526928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003332637,"threshold_uncertainty_score":0.006626487,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2070090424","doi":"10.1158/0008-5472.can-08-4754","title":"Peroxisome Proliferator-Activated Receptor-γ Contributes to the Inhibitory Effects of Embelin on Colon Carcinogenesis","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":76,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"XIAP; Peroxisome proliferator-activated receptor; Chemistry; Apoptosis; Carcinogenesis; Cancer research; Receptor; Endocrinology; Internal medicine; Colorectal cancer; Cancer; Biology; Medicine; Biochemistry; Programmed cell death; Caspase","authors":[{"name":"Yun Dai","is_ca":true},{"name":"Liang Qiao","is_ca":true},{"name":"Kwok Wah Chan","is_ca":false},{"name":"Mo Yang","is_ca":false},{"name":"Jieyu Ye","is_ca":false},{"name":"Juan Ma","is_ca":true},{"name":"Bing Zou","is_ca":true},{"name":"Qing Gu","is_ca":true},{"name":"Jide Wang","is_ca":true},{"name":"Roberta Pang","is_ca":true},{"name":"Hui Y. Lan","is_ca":true},{"name":"Benjamin C.Y. Wong","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1742573565843324,"gpt":0.5030674927568697,"spread":0.3288101361725373,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148872,0.0003688954,0.000223621,0.0002756497,0.0001100239,0.0002113956,0.0001452225,0.000257791,0.001080431],"category_scores_gemma":[0.0001104285,0.0001806007,0.000292203,0.0001222086,0.0002010454,0.0001842945,0.0002138555,0.0005756842,0.0002739336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490367,"about_ca_system_score_gemma":0.0001231938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002861142,"about_ca_topic_score_gemma":0.0003919945,"domain_scores_codex":[0.9999332,0.00001634495,0.000006502014,0.00001164581,0.00001264351,0.00001951943],"domain_scores_gemma":[0.9999187,0.00000838531,0.00003000076,0.000009390459,0.000008218851,0.00002527418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006440408,0.00003866532,0.0003754759,0.00005884119,0.000008296761,0.0001373296,0.00001286408,0.00004487155,0.9965944,0.0000405441,0.0000287242,0.002015883],"study_design_scores_gemma":[0.0001382514,0.001656132,0.04008768,0.00002557002,0.0001420583,0.001032599,0.0001179374,0.0008589047,0.9516095,0.0001466144,0.004172713,0.00001198991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923576,0.004137992,0.001663115,0.000167225,0.00002229594,0.00001746287,0.000112655,0.00005934051,0.00146237],"genre_scores_gemma":[0.9942795,0.00278846,0.0006231932,0.00008621494,0.000015961,0.00001609116,0.0001842753,0.00001089388,0.001995313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080431,"threshold_uncertainty_score":0.003614366,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1999544453","doi":"10.1039/b910133k","title":"Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry","year":2009,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":72,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Plumbagin; Cytotoxicity; Chemistry; Metal; Copper; Ligand (biochemistry); Fluorescence; Stereochemistry; Topoisomerase; DNA; Nuclear chemistry; In vitro; Biochemistry; Organic chemistry; Receptor; Biology","authors":[{"name":"Zhen‐Feng Chen","is_ca":false},{"name":"Ming‐Xiong Tan","is_ca":false},{"name":"Limin Liu","is_ca":false},{"name":"Yan‐Cheng Liu","is_ca":false},{"name":"Heng‐Shan Wang","is_ca":false},{"name":"Bin Yang","is_ca":false},{"name":"Yan Peng","is_ca":false},{"name":"Huagang Liu","is_ca":false},{"name":"Hong Liang","is_ca":false},{"name":"Chris Orvig","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1070014304390308,"gpt":0.3912184001388898,"spread":0.284216969699859,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000979377,0.00029249,0.0002377314,0.0002059693,0.0001454886,0.0001714947,0.000188533,0.0002520709,0.0008187415],"category_scores_gemma":[0.0001722618,0.00009422367,0.000128486,0.0002467784,0.0001382943,0.0001326309,0.0002541593,0.0002524283,0.0001653966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253665,"about_ca_system_score_gemma":0.0001784211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113884,"about_ca_topic_score_gemma":0.001230471,"domain_scores_codex":[0.9998872,0.00003535675,0.000007713199,0.00001707443,0.00003339353,0.00001916812],"domain_scores_gemma":[0.9999446,0.00001292092,0.000009414463,0.000007349199,0.00001452076,0.00001123552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005576166,0.00008489525,0.0008874239,0.0005767775,0.00003587708,0.0002524888,0.00005052916,0.0008387207,0.9741964,0.000197545,0.0003637857,0.02195789],"study_design_scores_gemma":[0.00003210175,0.001400844,0.005176824,0.00002306969,0.00004524603,0.0006388995,0.00003295391,0.001117802,0.9833401,0.00007318965,0.008110411,0.000008474603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648591,0.02671801,0.001866161,0.0002200118,0.00005948054,0.00005350843,0.00035952,0.00008390166,0.005780321],"genre_scores_gemma":[0.9909868,0.005354344,0.001017135,0.00004183626,0.00001420922,0.00002910993,0.0002676419,0.000004654999,0.002284197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00113884,"threshold_uncertainty_score":0.002738893,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2141287168","doi":"10.1002/adsc.200505248","title":"Synthesis of Aryl‐Substituted 1,4‐Benzoquinone <i>via</i> Water‐Promoted and In(OTf)<sub>3</sub>‐Catalyzed <i>in situ</i> Conjugate Addition‐Dehydrogenation of Aromatic Compounds to 1,4‐Benzoquinone in Water","year":2006,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":69,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Chemistry; Dehydrogenation; Regioselectivity; Catalysis; Conjugate; Nucleophile; Aryl; Medicinal chemistry; Quinone; In situ; 1,4-Benzoquinone; Benzoquinone; Nucleophilic addition; Organic chemistry; Alkyl","authors":[{"name":"Haibo Zhang","is_ca":false},{"name":"Li Liu","is_ca":false},{"name":"Xiaopeng Cheng","is_ca":false},{"name":"Dong Wang","is_ca":false},{"name":"Chao‐Jun Li","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02112138670805138,"gpt":0.2975020099596398,"spread":0.2763806232515884,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008607696,0.0003475003,0.0001742286,0.00007886427,0.0001404843,0.000142062,0.0002307682,0.0001582126,0.001520635],"category_scores_gemma":[0.0001118162,0.000166672,0.0001532657,0.00009572103,0.0001603531,0.00020757,0.0001382528,0.0002157685,0.0003894393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002012521,"about_ca_system_score_gemma":0.0002952058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005489233,"about_ca_topic_score_gemma":0.001006689,"domain_scores_codex":[0.9999484,0.000006769185,0.000003724791,0.00001386787,0.00001094842,0.00001637335],"domain_scores_gemma":[0.999936,0.000008847098,0.00002361923,0.000007883599,0.000009873869,0.00001378021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004158638,0.00001139565,0.00005902612,0.00007403725,0.00000298028,0.00005265079,0.00003072025,0.0001363118,0.9973041,0.0002022759,0.00004977689,0.002035095],"study_design_scores_gemma":[0.00001030394,0.0001453131,0.0002793247,0.000001527684,0.000005145521,0.00005559273,0.000006389923,0.0001564504,0.9973205,0.00002888555,0.001986557,0.000004039729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765708,0.001202373,0.01584585,0.00009020525,0.00006518436,0.00009982145,0.0004197808,0.0001646383,0.005541186],"genre_scores_gemma":[0.9910574,0.0005783005,0.005642901,0.00001570858,0.000004528107,0.0000283065,0.0001119867,0.00001833139,0.002542612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520635,"threshold_uncertainty_score":0.005087018,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3183131010","doi":"10.1016/j.cbi.2021.109574","title":"Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants","year":2021,"lang":"en","type":"review","venue":"Chemico-Biological Interactions","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":64,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Quinone; Chemistry; NAD+ kinase; Antioxidant; Oxidative stress; Oxidoreductase; Reactive oxygen species; Biochemistry; Enzyme","authors":[{"name":"Md Harunur Rashid","is_ca":true},{"name":"Dinesh Babu","is_ca":true},{"name":"Arno G. Siraki","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2558766741388018,"gpt":0.4384849016516901,"spread":0.1826082275128882,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003008942,0.0007852935,0.001057651,0.001361299,0.0001756084,0.0006612681,0.0005889123,0.0006152148,0.002850659],"category_scores_gemma":[0.0003190433,0.0001959656,0.000406758,0.001427928,0.0002219918,0.0006163371,0.0004205564,0.0008902323,0.001262969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003325808,"about_ca_system_score_gemma":0.0005818601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166841,"about_ca_topic_score_gemma":0.002601407,"domain_scores_codex":[0.9998994,0.00001420405,0.00001242569,0.00002145401,0.00004156775,0.00001097323],"domain_scores_gemma":[0.9998773,0.0000510923,0.00002498406,0.00000400042,0.00003291219,0.000009598229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001264392,0.000127086,0.0003317706,0.0215735,0.0001682948,0.0001869959,0.00005074107,0.0005189933,0.008952933,0.002509037,0.01255236,0.9529018],"study_design_scores_gemma":[0.00003112457,0.0002124763,0.002009261,0.002710542,0.0003204547,0.001060602,0.00005384372,0.0001626853,0.00354778,0.001313013,0.9885544,0.00002381689],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002909027,0.9985926,0.0001673786,0.00009630957,0.00006802072,0.000004581462,0.00002978502,0.000006217309,0.0007442965],"genre_scores_gemma":[0.001425505,0.9972143,0.0002559203,0.00008806998,0.00005866788,0.0000064037,0.00005455399,0.00000107696,0.000895498],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002850659,"threshold_uncertainty_score":0.009536386,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2102815947","doi":"10.1183/09031936.00084211","title":"Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH","year":2012,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":63,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Canadian Institutes of Health Research; Université Laval","keywords":"Plumbagin; Medicine; Apoptosis; Resistance (ecology); Cancer research; Immunology; Genetics; Biology; Ecology","authors":[{"name":"Audrey Courboulin","is_ca":true},{"name":"Marjorie Barrier","is_ca":true},{"name":"Tanya Perreault","is_ca":true},{"name":"Pierre Bonnet","is_ca":false},{"name":"Véronique Tremblay","is_ca":true},{"name":"Roxane Paulin","is_ca":true},{"name":"Ève Tremblay","is_ca":true},{"name":"Caroline Lambert","is_ca":true},{"name":"Maria Jacob","is_ca":true},{"name":"Sandra N. Bonnet","is_ca":true},{"name":"Steeve Provencher","is_ca":true},{"name":"Sébastien Bonnet","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1446492340617503,"gpt":0.4142097170000998,"spread":0.2695604829383496,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338058,0.0003247521,0.0004200432,0.0003153855,0.0001349036,0.000181475,0.0002262911,0.000336376,0.001481749],"category_scores_gemma":[0.0001816596,0.0001010601,0.0002047592,0.0001216197,0.0003242648,0.0002358768,0.0001588771,0.0007504391,0.0001930081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653972,"about_ca_system_score_gemma":0.0002259168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002454984,"about_ca_topic_score_gemma":0.0004190377,"domain_scores_codex":[0.999918,0.00002766287,0.000005654637,0.00001297625,0.00002047053,0.00001522736],"domain_scores_gemma":[0.9998945,0.00002455769,0.00002892582,0.00001241744,0.00001043956,0.00002900499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001529542,0.0004398572,0.00020868,0.0002058379,0.00002445949,0.0001443041,0.000031399,0.000160235,0.9881121,0.0001354991,0.00009574953,0.008912298],"study_design_scores_gemma":[0.0005048485,0.0124752,0.00652711,0.00003042147,0.00005634101,0.0009317942,0.00006883447,0.00110651,0.9711006,0.0002204101,0.006967378,0.00001057668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865536,0.007218946,0.00313494,0.0002899788,0.00007168621,0.0001093276,0.0001999703,0.0003172066,0.002104158],"genre_scores_gemma":[0.9913988,0.004098416,0.001654471,0.00009095485,0.00004095569,0.00009153596,0.0003093139,0.00003069617,0.002284882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481749,"threshold_uncertainty_score":0.004956901,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1974973003","doi":"10.1371/journal.pone.0107149","title":"Fatty Acid Esters of Phloridzin Induce Apoptosis of Human Liver Cancer Cells through Altered Gene Expression","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":62,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Atlantic Canada Opportunities Agency; Faculty of Medicine, Dalhousie University; Dalhousie University","keywords":"Phloretin; Cancer cell; Biochemistry; Apoptosis; Chemistry; Biology; Molecular biology; Cancer","authors":[{"name":"Sandhya Nair","is_ca":true},{"name":"Ziaullah","is_ca":true},{"name":"H.P. Vasantha Rupasinghe","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2589636743971476,"gpt":0.3984888751547728,"spread":0.1395252007576252,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000624571,0.00020386,0.0001475163,0.0001285873,0.00005954403,0.0001147038,0.00008378772,0.0001159228,0.0006253613],"category_scores_gemma":[0.00006540486,0.00008165314,0.0001660882,0.0001713437,0.00009610425,0.0001193525,0.0001180455,0.0002958584,0.0001452867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001589586,"about_ca_system_score_gemma":0.0001240394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007403687,"about_ca_topic_score_gemma":0.001063918,"domain_scores_codex":[0.9999392,0.000009457553,0.000007428758,0.00001146217,0.00001893054,0.00001348727],"domain_scores_gemma":[0.9999681,0.000005877271,0.000009437049,0.000004316877,0.000006635236,0.000005675451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001026091,0.00001084257,0.0001631471,0.00002721902,0.000003843063,0.00003130355,0.00001008703,0.00002749183,0.9985643,0.00002241978,0.00001130543,0.001025523],"study_design_scores_gemma":[0.00001017509,0.0003040214,0.002336373,0.000002851806,0.00001186538,0.0001140929,0.00001605564,0.0001520624,0.9959979,0.00001187215,0.001041015,0.000001646268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944719,0.002672,0.001518221,0.00006564098,0.00001375976,0.00002733272,0.000228457,0.00002334897,0.000979376],"genre_scores_gemma":[0.9923216,0.002291094,0.002064289,0.00005997499,0.000006807009,0.00003612809,0.0007410561,0.000007576333,0.002471514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007403687,"threshold_uncertainty_score":0.002092063,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4243529542","doi":"10.1155/2009/154321","title":"Structural analysis of DNA and RNA interactions with antioxidant flavonoids","year":2009,"lang":"en","type":"article","venue":"Spectroscopy An International Journal","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":62,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; National and Kapodistrian University of Athens; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Agricultural University of Athens; Islamic Azad University","keywords":"Chemistry; DNA; Stereochemistry; Delphinidin; Kaempferol; Antioxidant; Apigenin; Morin; Adduct; RNA; Flavonoid; Biochemistry; Organic chemistry; Cyanidin","authors":[{"name":"Charalabos D. Kanakis","is_ca":false},{"name":"Sh. Nafisi","is_ca":false},{"name":"Mehdi Rajabi","is_ca":false},{"name":"Azadeh Shadaloi","is_ca":false},{"name":"Petros Α. Tarantilis","is_ca":false},{"name":"Moschos G. Polissiou","is_ca":false},{"name":"J. Bariyanga","is_ca":false},{"name":"H.A. Tajmir‐Riahi","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06255516058498257,"gpt":0.4490929548708461,"spread":0.3865377942858635,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126321,0.0002152922,0.0001923514,0.0002094589,0.0001367601,0.0001103199,0.000200452,0.0002979684,0.001357822],"category_scores_gemma":[0.0002390777,0.0001315179,0.0003078384,0.0001504071,0.0001064749,0.0002243537,0.0001052811,0.0003264153,0.0003007855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445541,"about_ca_system_score_gemma":0.0001064932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000885656,"about_ca_topic_score_gemma":0.0006811575,"domain_scores_codex":[0.9998956,0.00001961751,0.000003927605,0.00002865978,0.00003068597,0.00002158585],"domain_scores_gemma":[0.9998636,0.00004082875,0.00004523401,0.00000628267,0.00003265107,0.0000113271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007673676,0.0000126811,0.000653479,0.00014489,0.00002106324,0.00004958506,0.00004351812,0.0003909447,0.9961265,0.0001005564,0.00004898952,0.002331222],"study_design_scores_gemma":[0.00001704821,0.0005297938,0.0223305,0.00002391643,0.00007301186,0.0002950054,0.0001182643,0.003734553,0.9668518,0.0002060706,0.00579626,0.00002381696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875519,0.006258316,0.003842596,0.0001131473,0.0000140888,0.00002316755,0.000339706,0.00003987909,0.001817091],"genre_scores_gemma":[0.9936057,0.002021028,0.002368786,0.00008052419,0.000007825656,0.0000235925,0.0004670481,0.00001111262,0.001414264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357822,"threshold_uncertainty_score":0.004542351,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2082627431","doi":"10.1139/y2012-134","title":"Anticancer activity and mechanism of juglone on human cervical carcinoma HeLa cells","year":2012,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":62,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"","keywords":"Juglone; HeLa; Mechanism (biology); Cervical carcinoma; Carcinoma; Chemistry; Cancer research; Cell biology; In vitro; Biology; Pharmacology; Cervical cancer; Biochemistry; Medicine; Cancer; Internal medicine","authors":[{"name":"Wei Zhang","is_ca":false},{"name":"Anheng Liu","is_ca":false},{"name":"Yan Li","is_ca":false},{"name":"Xingyu Zhao","is_ca":false},{"name":"Shijie Lv","is_ca":false},{"name":"Wenhe Zhu","is_ca":false},{"name":"Ying Jin","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1071163754653891,"gpt":0.4008443807959901,"spread":0.2937280053306009,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007741532,0.0003087758,0.0004228788,0.0004491185,0.0002337854,0.0001619368,0.0002197863,0.0001851027,0.00122337],"category_scores_gemma":[0.00008288014,0.0001012398,0.0003656616,0.0002837673,0.0001941754,0.0001651149,0.0001349028,0.0002828562,0.0002843316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250287,"about_ca_system_score_gemma":0.000268543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285068,"about_ca_topic_score_gemma":0.001561043,"domain_scores_codex":[0.999948,0.00001152809,0.000003663979,0.000009287562,0.00001348953,0.0000140305],"domain_scores_gemma":[0.999975,0.000005139333,0.000005728662,0.000002717081,0.000006633934,0.000004811262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004483376,0.0001934193,0.0007207441,0.0005665775,0.00002613776,0.0003080247,0.0000569841,0.0004518102,0.9853553,0.0003011476,0.0004515393,0.01111999],"study_design_scores_gemma":[0.0001109416,0.002399331,0.01319028,0.00004153045,0.00008353526,0.0006595572,0.00007119459,0.0009178738,0.9733729,0.0001709522,0.008967856,0.00001408131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489871,0.03861175,0.002278272,0.000550664,0.0001229282,0.0001335086,0.001096788,0.0001760575,0.008042952],"genre_scores_gemma":[0.979982,0.0147651,0.0009590982,0.0001695018,0.00003317641,0.00007801123,0.0005653425,0.00001153382,0.003436193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285068,"threshold_uncertainty_score":0.004092515,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1979553293","doi":"10.1016/j.molimm.2005.10.006","title":"Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: A new mechanism of action for SHP-2","year":2005,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":61,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"","keywords":"Protein tyrosine phosphatase; Phosphorylation; Phosphatase; Cell biology; Receptor; Activator (genetics); Repressor; Tyrosine phosphorylation; Biology; Biochemistry; Chemistry; Transcription factor; Gene","authors":[{"name":"Manon Richard","is_ca":true},{"name":"Nathalie Thibault","is_ca":true},{"name":"Patricia Veilleux","is_ca":true},{"name":"Geneviève Gareau-Pagé","is_ca":true},{"name":"André Beaulieu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1722075736972827,"gpt":0.4422539289834221,"spread":0.2700463552861395,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742113,0.0002647783,0.0002538762,0.00009741945,0.0001304154,0.0002336227,0.0002415781,0.0003328939,0.002075463],"category_scores_gemma":[0.000136171,0.0001092013,0.000266817,0.0000535864,0.0001862778,0.0001845294,0.0002063288,0.0005896023,0.0003401575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003075688,"about_ca_system_score_gemma":0.0002053258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004035665,"about_ca_topic_score_gemma":0.0007045574,"domain_scores_codex":[0.9998955,0.00001994391,0.000006660709,0.00001283139,0.00002503094,0.00004000391],"domain_scores_gemma":[0.9999278,0.00001634162,0.00001456926,0.00001144458,0.000008655785,0.00002120559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003405002,0.00002484938,0.000194042,0.00001770055,0.00000455274,0.00006148164,0.000007550815,0.00003095456,0.9982627,0.0001553961,0.00008018427,0.0008201129],"study_design_scores_gemma":[0.00006506061,0.0002023649,0.005892959,0.000002770026,0.000008363781,0.0002184661,0.00001754568,0.0006110751,0.9916352,0.00007049485,0.001272965,0.000002730847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957782,0.0007495953,0.00182056,0.0002910683,0.00004131975,0.00002159333,0.0001402182,0.00003934498,0.001118094],"genre_scores_gemma":[0.9964857,0.0002796688,0.0009468006,0.0001151667,0.00002041185,0.00002052043,0.0002340749,0.00001106747,0.0018865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002075463,"threshold_uncertainty_score":0.006943107,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2125465637","doi":"10.1021/jo701435p","title":"Total Synthesis of Streptonigrone","year":2007,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":60,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Total synthesis; Quinoline; Sequence (biology); Combinatorial chemistry; Surface modification; Key (lock); Stereochemistry; Organic chemistry; Biochemistry; Computer science","authors":[{"name":"Bryan Chan","is_ca":true},{"name":"Marco A. Ciufolini","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05438509649721856,"gpt":0.3783404282527812,"spread":0.3239553317555627,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132917,0.0004180846,0.0003580913,0.0003660172,0.0002444604,0.0002426889,0.0002650372,0.0001703619,0.004141645],"category_scores_gemma":[0.0001245373,0.00013113,0.0001733268,0.0003182483,0.000134524,0.0002738376,0.0003172205,0.0006058784,0.001760667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521019,"about_ca_system_score_gemma":0.0004675853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000348369,"about_ca_topic_score_gemma":0.001020434,"domain_scores_codex":[0.9998792,0.00001668743,0.000008643107,0.00002623909,0.00003728017,0.00003186818],"domain_scores_gemma":[0.9999365,0.000008237728,0.000009518133,0.00001007373,0.00001266035,0.00002307692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001611124,0.0001475163,0.0001769686,0.0004821362,0.00002440133,0.000329147,0.0001028117,0.001640604,0.9362948,0.00533692,0.001426011,0.05387756],"study_design_scores_gemma":[0.00006790018,0.001509823,0.001312496,0.00005038046,0.00003334626,0.0005760874,0.00004778873,0.001455734,0.9037119,0.0008454525,0.0903494,0.00003966169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7202465,0.01149782,0.1213908,0.0004025254,0.0007493959,0.001171954,0.007652636,0.002078226,0.1348101],"genre_scores_gemma":[0.9146418,0.008420495,0.0473591,0.0001674538,0.0000622658,0.0003490949,0.002493485,0.0001321887,0.02637417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004141645,"threshold_uncertainty_score":0.01385522,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2024421129","doi":"10.1155/2015/751348","title":"Advances in the Research and Development of Natural Health Products as Main Stream Cancer Therapeutics","year":2015,"lang":"en","type":"review","venue":"Evidence-based Complementary and Alternative Medicine","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":59,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; University of Windsor","funders":"","keywords":"Cancer; Medicine; Cancer therapy; Disease; Cancer treatment; Intensive care medicine; Internal medicine","authors":[{"name":"Pamela Ovadje","is_ca":true},{"name":"Alessia Roma","is_ca":true},{"name":"Matthew Steckle","is_ca":true},{"name":"Leah Nicoletti","is_ca":true},{"name":"John T. Arnason","is_ca":true},{"name":"Siyaram Pandey","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.7226954710158353,"gpt":0.6319151726244708,"spread":0.09078029839136448,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006244152,0.0006285195,0.0009406664,0.002602158,0.0003527727,0.001096301,0.000545516,0.000874214,0.004551004],"category_scores_gemma":[0.0006179534,0.0002594463,0.0006350554,0.002066999,0.0004755754,0.001298707,0.0006792141,0.001665386,0.001507957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005488239,"about_ca_system_score_gemma":0.001302093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007938101,"about_ca_topic_score_gemma":0.001597055,"domain_scores_codex":[0.9997364,0.00004287667,0.00003482642,0.00004696074,0.0001133502,0.00002567422],"domain_scores_gemma":[0.9996265,0.0001907073,0.00005243212,0.00001449599,0.00008759266,0.00002820116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008417906,0.0001668579,0.000324423,0.03623728,0.00009698176,0.0003642292,0.0001398546,0.000490506,0.008530014,0.01118804,0.01244119,0.9299363],"study_design_scores_gemma":[0.00001249787,0.000123267,0.0009301769,0.003433926,0.0001084565,0.00103089,0.0000805713,0.000126996,0.002263229,0.00314137,0.9887275,0.0000211193],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005303257,0.9948744,0.000514994,0.0003656744,0.0001530039,0.00001242003,0.0000447253,0.00001364883,0.003490801],"genre_scores_gemma":[0.002238351,0.9962085,0.0005582336,0.0001642388,0.00008886457,0.000009075474,0.00004169704,0.000002112437,0.0006888823],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004551004,"threshold_uncertainty_score":0.01522458,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2025424557","doi":"10.1139/y10-085","title":"Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":58,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Apoptosis; Annexin; Cell growth; Molecular biology; Cell biology; Cell cycle; Biology; Programmed cell death; Fragmentation (computing); Cancer cell; Fas receptor; Flow cytometry; Cell; MTT assay; Chemistry; Biochemistry; Cancer","authors":[{"name":"Nie Yingkun","is_ca":false},{"name":"Zhu Lvsong","is_ca":false},{"name":"YU Hui-min","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06374126087315204,"gpt":0.3714839500300471,"spread":0.3077426891568951,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007888263,0.0003113874,0.0003195324,0.000281522,0.000159138,0.0001572958,0.00008283045,0.0001525354,0.00119525],"category_scores_gemma":[0.00008515838,0.0000849309,0.0002882575,0.0002166101,0.0001006684,0.0001258591,0.0001457332,0.0003410708,0.0003958219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000226705,"about_ca_system_score_gemma":0.0002335895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002088547,"about_ca_topic_score_gemma":0.003519871,"domain_scores_codex":[0.9999154,0.00001741231,0.000009749519,0.00001037297,0.00002352669,0.00002359079],"domain_scores_gemma":[0.9999595,0.000007792843,0.000007309508,0.000006144308,0.00001038956,0.000008891443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005069958,0.0001518249,0.0008674833,0.0002125628,0.00002136916,0.0002427037,0.00005407178,0.0001640141,0.9906268,0.00008050312,0.0003338158,0.006737906],"study_design_scores_gemma":[0.0001596677,0.002266795,0.01700519,0.00003658069,0.00005737009,0.000905139,0.0001779005,0.0013959,0.9677721,0.0001088611,0.01010086,0.00001367644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821671,0.01021579,0.002094234,0.0002592316,0.00009481525,0.00006022779,0.0006355487,0.0001318553,0.004341073],"genre_scores_gemma":[0.9899718,0.003826878,0.0006397759,0.00009715063,0.00001764122,0.0000467247,0.001147961,0.00001407411,0.004237979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002088547,"threshold_uncertainty_score":0.004152775,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2809783990","doi":"10.1002/anie.201804351","title":"Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":55,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Australian Research Council; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Biosynthesis; Halogenation; Total synthesis; Stereochemistry; Biomimetic synthesis; Enzyme; Chlorine; Biochemistry; Organic chemistry","authors":[{"name":"Lauren A. M. Murray","is_ca":false},{"name":"Shaun M. K. McKinnie","is_ca":false},{"name":"Henry P. Pepper","is_ca":false},{"name":"Reto Erni","is_ca":false},{"name":"Zachary D. Miles","is_ca":false},{"name":"Michelle C. Cruickshank","is_ca":false},{"name":"Borja López‐Pérez","is_ca":false},{"name":"Bradley S. Moore","is_ca":false},{"name":"Jonathan H. George","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05349005272961124,"gpt":0.3512378066095562,"spread":0.2977477538799449,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828203,0.0004524651,0.000236999,0.000273597,0.0002320147,0.0006052618,0.0003341241,0.0002318132,0.00118661],"category_scores_gemma":[0.0002476372,0.0002379965,0.000348389,0.000234742,0.0005105786,0.0007240864,0.0005947602,0.0006978106,0.000630171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004572743,"about_ca_system_score_gemma":0.0006700915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005700125,"about_ca_topic_score_gemma":0.0009188101,"domain_scores_codex":[0.9998685,0.00001772524,0.000008382667,0.000040713,0.00003185505,0.00003286319],"domain_scores_gemma":[0.9998586,0.00001520704,0.00002785046,0.00004135917,0.00002901471,0.00002788182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009917369,0.00002000535,0.0003669107,0.0001283972,0.0000146109,0.0002335576,0.00006393877,0.0007101464,0.9736605,0.007173586,0.0001282103,0.01740096],"study_design_scores_gemma":[0.00001023913,0.0003211135,0.0007065597,0.00001736802,0.00003126312,0.0004396587,0.00005310171,0.001625397,0.980079,0.003041168,0.01366173,0.00001336844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8084412,0.00416147,0.1628694,0.0003897997,0.0001996932,0.0001628357,0.001015745,0.0008485096,0.02191146],"genre_scores_gemma":[0.9621344,0.002357908,0.03045181,0.00007053962,0.00001532583,0.00004450631,0.0006018193,0.00009517578,0.00422847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118661,"threshold_uncertainty_score":0.00396961,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2032786541","doi":"10.1016/s0022-2836(03)00444-3","title":"Structural Insights into the Activation of P.vivax Plasmepsin","year":2003,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":55,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canada Research Chairs","keywords":"Biology; Computational biology","authors":[{"name":"Nina Bernstein","is_ca":true},{"name":"M.M. Cherney","is_ca":true},{"name":"Charles A. Yowell","is_ca":false},{"name":"John B. Dame","is_ca":false},{"name":"Michael N.G. James","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07219434717894091,"gpt":0.4173164477245963,"spread":0.3451221005456554,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131492,0.0002854575,0.0001611965,0.00006495429,0.0001981549,0.000202801,0.0002763694,0.0002783283,0.001959201],"category_scores_gemma":[0.0001175366,0.00009742242,0.0001636395,0.00006410339,0.0002104899,0.0002154805,0.0001974463,0.0007379949,0.0003469854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315504,"about_ca_system_score_gemma":0.0002394066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004954207,"about_ca_topic_score_gemma":0.0005421322,"domain_scores_codex":[0.9999547,0.000009419534,0.00000269945,0.000007407939,0.00001057968,0.00001509913],"domain_scores_gemma":[0.9999665,0.00001000191,0.000008811666,0.00000240664,0.00000412445,0.000008087797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000484253,0.00005030206,0.0002813515,0.00007774963,0.00001379377,0.0008751919,0.00008137925,0.001612517,0.9874653,0.003877928,0.0003497542,0.004830352],"study_design_scores_gemma":[0.0001782134,0.0006770603,0.003661964,0.00002419172,0.0000325152,0.001617585,0.0001689148,0.006932159,0.968488,0.001728027,0.01646955,0.00002183205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832502,0.001869668,0.007340583,0.0009583855,0.0000857063,0.00004942564,0.0002337521,0.00005277967,0.006159383],"genre_scores_gemma":[0.9947042,0.001025861,0.001651383,0.0001961953,0.00001267002,0.00001196105,0.0002419397,0.000005602592,0.002150163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001959201,"threshold_uncertainty_score":0.006554186,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3031246863","doi":"10.1038/s41438-020-0301-9","title":"Hybrid de novo genome assembly of red gromwell (Lithospermum erythrorhizon) reveals evolutionary insight into shikonin biosynthesis","year":2020,"lang":"en","type":"article","venue":"Horticulture Research","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"McGill University; Purdue University; U.S. Department of Agriculture; National Institute of Food and Agriculture; National Science Foundation","keywords":"Biology; Genome; Sequence assembly; Gene; Proteome; Transcriptome; Botany; Whole genome sequencing; Genetics; Gene expression","authors":[{"name":"Robert Auber","is_ca":false},{"name":"Thiti Suttiyut","is_ca":false},{"name":"Rachel M. McCoy","is_ca":false},{"name":"Manoj Ghaste","is_ca":false},{"name":"Joseph W. Crook","is_ca":false},{"name":"Amanda L. Pendleton","is_ca":false},{"name":"Joshua R. Widhalm","is_ca":false},{"name":"Jennifer H. Wisecaver","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.183473896469251,"gpt":0.4439089783615162,"spread":0.2604350818922652,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004699696,0.0009955363,0.001237741,0.001306536,0.0006681888,0.001138833,0.0006275441,0.0006380928,0.00146149],"category_scores_gemma":[0.000894083,0.000583678,0.001557184,0.001426708,0.0002394253,0.0005013028,0.0008297841,0.001223625,0.001297769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007028623,"about_ca_system_score_gemma":0.001003887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005361516,"about_ca_topic_score_gemma":0.009484253,"domain_scores_codex":[0.999647,0.00003426175,0.00002612262,0.0001610743,0.00007690918,0.00005464803],"domain_scores_gemma":[0.9996223,0.0001024743,0.0000728841,0.00003904942,0.00009617765,0.0000670037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006619717,0.00008096218,0.005365867,0.0008735239,0.0001692958,0.0007578199,0.0003698627,0.003752516,0.964269,0.0005106506,0.001255697,0.02193276],"study_design_scores_gemma":[0.000406529,0.001121251,0.2124012,0.0005527497,0.00146109,0.00231193,0.001298044,0.1036036,0.5408785,0.002608668,0.1329373,0.000419091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7883369,0.004679104,0.1245068,0.0004724169,0.0002284762,0.0005343407,0.07249372,0.003863666,0.004884719],"genre_scores_gemma":[0.4841553,0.002688018,0.2770827,0.0002447581,0.00005184344,0.0005838887,0.2278421,0.002024459,0.005327023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005361516,"threshold_uncertainty_score":0.01066065,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2167995914","doi":"10.3233/spe-2009-0368","title":"Structural analysis of DNA and RNA interactions with antioxidant flavonoids","year":2009,"lang":"en","type":"article","venue":"","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Chemistry; Delphinidin; DNA; Kaempferol; Apigenin; RNA; Flavonoid; Antioxidant; Stereochemistry; Biochemistry; Naringin; Cyanidin; Chromatography","authors":[{"name":"Charalabos D. Kanakis","is_ca":false},{"name":"Sh. Nafisi","is_ca":true},{"name":"Mehdi Rajabi","is_ca":true},{"name":"Azadeh Shadaloi","is_ca":false},{"name":"Petros Α. Tarantilis","is_ca":false},{"name":"Moschos G. Polissiou","is_ca":false},{"name":"J. Bariyanga","is_ca":false},{"name":"H.A. Tajmir‐Riahi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08289936099426008,"gpt":0.4195633169172416,"spread":0.3366639559229815,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361048,0.0002277752,0.0002008067,0.000227857,0.0001417909,0.0001110615,0.0002067788,0.000302003,0.001446923],"category_scores_gemma":[0.0002509434,0.0001357029,0.0003328209,0.0001602439,0.0001056976,0.00023351,0.0001127908,0.0003362685,0.0003029434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002614963,"about_ca_system_score_gemma":0.0001095924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009646606,"about_ca_topic_score_gemma":0.0007388942,"domain_scores_codex":[0.9998879,0.00001995653,0.000004197646,0.00003100942,0.00003363362,0.00002328296],"domain_scores_gemma":[0.9998685,0.0000392598,0.00004213026,0.000006118706,0.00003313497,0.00001089314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008224462,0.00001414651,0.0007160369,0.0002014888,0.00002692356,0.00005332984,0.00004921858,0.000443956,0.9950927,0.0001311423,0.00006800161,0.003120884],"study_design_scores_gemma":[0.00001804233,0.0005607405,0.01928029,0.00002890964,0.00008220047,0.0003018378,0.0001166082,0.003583334,0.9682056,0.0002263264,0.007570871,0.00002527929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828363,0.009414881,0.004700261,0.0001406527,0.00001983988,0.00003051926,0.000438375,0.00004935049,0.002369875],"genre_scores_gemma":[0.9919568,0.002817736,0.002788163,0.0001031037,0.00001009164,0.00002906704,0.0005794271,0.00001366562,0.001701921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446923,"threshold_uncertainty_score":0.004840493,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2951239749","doi":"10.1021/ol016562k","title":"The Diels−Alder Reactions of Quinone Imine Ketals:  A Versatile Synthesis of Highly Substituted 5-Methoxyindoles","year":2001,"lang":"en","type":"article","venue":"Organic Letters","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":51,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Imine; Quinone; Yield (engineering); Organic chemistry; Diels–Alder reaction; Combinatorial chemistry; Catalysis","authors":[{"name":"Scott C. Banfield","is_ca":true},{"name":"Dylan B. England","is_ca":true},{"name":"Michael A. Kerr","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07855024250679302,"gpt":0.3689226271181528,"spread":0.2903723846113598,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005247577,0.0006495626,0.000256387,0.0004006017,0.0002465317,0.00027078,0.0005909199,0.0004647419,0.001837953],"category_scores_gemma":[0.0002421264,0.0003279071,0.0002935762,0.0002751925,0.0003739343,0.0006078253,0.0005365967,0.0007113568,0.0008374371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002844276,"about_ca_system_score_gemma":0.0001813129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001739326,"about_ca_topic_score_gemma":0.0005653573,"domain_scores_codex":[0.9998019,0.00004894142,0.00001476661,0.00003171612,0.00004339225,0.00005925234],"domain_scores_gemma":[0.9999194,0.00001433605,0.00002206354,0.00001289042,0.000009244032,0.00002196384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001913066,0.0001030674,0.0001633074,0.0005242969,0.00003843265,0.0007616524,0.0003716983,0.001448296,0.9638107,0.00683001,0.0008202278,0.024937],"study_design_scores_gemma":[0.00005812648,0.0009118662,0.0008675084,0.00002500962,0.00003368407,0.0009641543,0.00004812943,0.001450599,0.9720765,0.001177446,0.02233387,0.00005310804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8125598,0.02853803,0.1196222,0.0008404572,0.0005892397,0.0004820971,0.000686634,0.0008998793,0.03578169],"genre_scores_gemma":[0.9634371,0.009360361,0.01997672,0.0001088154,0.00007713246,0.0001200978,0.0002348279,0.00005455782,0.006630392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837953,"threshold_uncertainty_score":0.006148517,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2901553097","doi":"10.1039/c8ra07060a","title":"Facile synthesis of indole heterocyclic compounds based micellar nano anti-cancer drugs","year":2018,"lang":"en","type":"article","venue":"RSC Advances","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":50,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Institute of Population and Public Health; King Saud University","keywords":"Chemistry; Adduct; Indole test; Combinatorial chemistry; Micelle; Nano-; DNA adduct; Nuclear chemistry; Organic chemistry; Aqueous solution; Materials science","authors":[{"name":"Imran Ali","is_ca":false},{"name":"Sofi Danish Mukhtar","is_ca":false},{"name":"Ming‐Fa Hsieh","is_ca":false},{"name":"Zeid A. ALOthman","is_ca":false},{"name":"Abdulrahman Al‐Warthan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07295990619165443,"gpt":0.4079932002418778,"spread":0.3350332940502234,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007990889,0.0002761358,0.000188284,0.0001480265,0.0001030984,0.0001639894,0.000220496,0.000204959,0.001500003],"category_scores_gemma":[0.00005660627,0.00009195347,0.0001607209,0.0001535999,0.00009350895,0.0001928289,0.0001123701,0.0003473975,0.0006859422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184155,"about_ca_system_score_gemma":0.0002089602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004189963,"about_ca_topic_score_gemma":0.001629607,"domain_scores_codex":[0.9999602,0.000003609762,0.000003024367,0.000009457806,0.00001061937,0.00001313833],"domain_scores_gemma":[0.9999807,0.000002258413,0.000006878126,0.00000225077,0.000003843171,0.000004035948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004301938,0.00005508332,0.00006502539,0.0001451152,0.000007239016,0.0001241028,0.00002438659,0.0003355119,0.9898381,0.0008333558,0.000257523,0.008271518],"study_design_scores_gemma":[0.00001175806,0.0003320946,0.0005417613,0.00000720814,0.00001360292,0.0001013478,0.00001009376,0.0009043251,0.988101,0.0000739061,0.009893431,0.000009472917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8865059,0.01417357,0.06772301,0.0004443961,0.0002654582,0.0004084636,0.002065149,0.001022356,0.02739174],"genre_scores_gemma":[0.9677002,0.004558188,0.01688882,0.0001440014,0.0000247996,0.0001460159,0.0005921491,0.0000477301,0.009898009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001500003,"threshold_uncertainty_score":0.005018055,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2084996945","doi":"10.2478/bf02476181","title":"Antiinflammatory, analgesic and kinase inhibition activities of some acridine derivatives","year":2004,"lang":"en","type":"article","venue":"Open Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":49,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Indian Council for Cultural Relations; University of Alberta","keywords":"Chemistry; Condensation; Analgesic; Acridine; Aryl; Condensation reaction; Medicinal chemistry; Organic chemistry; Stereochemistry; Pharmacology; Catalysis; Medicine","authors":[{"name":"Sham M. Sondhi","is_ca":false},{"name":"G. Bhattacharjee","is_ca":false},{"name":"Rafid K. Jameel","is_ca":false},{"name":"Rakesh Shukla","is_ca":false},{"name":"Ram Raghubir","is_ca":false},{"name":"Olivier Lozach","is_ca":false},{"name":"Laurent Meijer","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08792190833813561,"gpt":0.407376147161374,"spread":0.3194542388232384,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104643,0.0004004276,0.000171757,0.0002852265,0.0001550357,0.0001194997,0.000148229,0.0001254491,0.0018931],"category_scores_gemma":[0.0001053262,0.0001048907,0.0001748377,0.0001882067,0.0001710324,0.0001231154,0.00009593879,0.0002790568,0.0003123855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249699,"about_ca_system_score_gemma":0.0001691607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000607134,"about_ca_topic_score_gemma":0.001121798,"domain_scores_codex":[0.99993,0.0000137908,0.000007500067,0.00000911233,0.00001774304,0.00002175509],"domain_scores_gemma":[0.9999313,0.000009708542,0.00002063095,0.000005509874,0.00001150459,0.00002126201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001990909,0.00003807621,0.0001026535,0.0001284441,0.000005778285,0.00008789478,0.00001888484,0.0001579968,0.9966959,0.00007945653,0.00005627052,0.002429486],"study_design_scores_gemma":[0.0000482518,0.001561516,0.0030321,0.00001020828,0.00002372582,0.0002296643,0.00001656144,0.0002992529,0.9924252,0.00003132546,0.002311614,0.00001054386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860139,0.007986742,0.001648019,0.0001397386,0.00004642583,0.00004543042,0.0003689399,0.00008421654,0.003666664],"genre_scores_gemma":[0.9938246,0.002737615,0.001483794,0.00003138812,0.00002557118,0.0000230632,0.0003563871,0.000008390349,0.001509229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018931,"threshold_uncertainty_score":0.006333053,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2017171169","doi":"10.1371/journal.pone.0022510","title":"Shikonin Increases Glucose Uptake in Skeletal Muscle Cells and Improves Plasma Glucose Levels in Diabetic Goto-Kakizaki Rats","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Stockholms Universitet; Hospital for Sick Children; Medical Research Council; Vetenskapsrådet; National Health and Medical Research Council; Karolinska Institutet","keywords":"Glucose uptake; GLUT4; Internal medicine; Skeletal muscle; Endocrinology; Insulin; Glucose transporter; Glucose homeostasis; Myocyte; Carbohydrate metabolism; Chemistry; Snf3; Insulin resistance; Biology; Medicine","authors":[{"name":"Anette I. Öberg","is_ca":false},{"name":"Kamal Yassin","is_ca":false},{"name":"Robert I. Csikasz","is_ca":false},{"name":"Nodi Dehvari","is_ca":false},{"name":"Irina G. Shabalina","is_ca":false},{"name":"Dana S. Hutchinson","is_ca":false},{"name":"Mona Wilcke","is_ca":false},{"name":"Claes‐Göran Östenson","is_ca":false},{"name":"Tore Bengtsson","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1643071748128553,"gpt":0.3333436180146576,"spread":0.1690364432018023,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997116,0.001356986,0.0008591146,0.0009789011,0.0003401297,0.0002936199,0.000438203,0.0006648651,0.002368997],"category_scores_gemma":[0.0001107901,0.0003838073,0.0005908717,0.0004406582,0.00046964,0.0004821288,0.000302892,0.00141802,0.0004805434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004432041,"about_ca_system_score_gemma":0.0004453689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001517533,"about_ca_topic_score_gemma":0.002789691,"domain_scores_codex":[0.999844,0.00001488402,0.00001951981,0.00003371808,0.00003789836,0.00004992132],"domain_scores_gemma":[0.9997383,0.00001292396,0.0000863826,0.00002276676,0.00002548728,0.0001140597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003443014,0.0008537961,0.0006843798,0.000151781,0.00003365821,0.00009198382,0.00003293889,0.00005025739,0.9916227,0.00004587899,0.00007771268,0.002911704],"study_design_scores_gemma":[0.001159631,0.01558738,0.02829852,0.00005716895,0.0002315703,0.0002881644,0.0002651335,0.0008192703,0.9507525,0.0001114177,0.002394238,0.00003500919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966747,0.001172893,0.0007100696,0.0001628239,0.00006061045,0.00004766352,0.0003174595,0.0001675343,0.0006864159],"genre_scores_gemma":[0.9872569,0.002523214,0.002566334,0.0002241969,0.00004167499,0.0001480341,0.001042687,0.00004682374,0.006150274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002368997,"threshold_uncertainty_score":0.007925034,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2154150745","doi":"10.1073/pnas.0803171105","title":"Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naïve vs. effector/memory CD4 <sup>+</sup> T cells","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Effector; Cytokine; Biology; IL-2 receptor; Interleukin 21; Cell biology; Gene knockdown; T cell; Molecular biology; Immunology; Cell culture; Immune system","authors":[{"name":"Kiri Honma","is_ca":false},{"name":"Daisuke Kimura","is_ca":false},{"name":"Norio Tominaga","is_ca":false},{"name":"Mana Miyakoda","is_ca":false},{"name":"T. Matsuyama","is_ca":true},{"name":"Katsuyuki Yui","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.105017909392948,"gpt":0.3688505206149645,"spread":0.2638326112220166,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002400127,0.0005427159,0.0004260535,0.0004133581,0.0001791649,0.0005916043,0.0002900005,0.0005043367,0.001764904],"category_scores_gemma":[0.0002209769,0.0002555404,0.0004590398,0.0001718073,0.0003970997,0.0004116812,0.0001840311,0.0009757036,0.0008087838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000429181,"about_ca_system_score_gemma":0.0002172853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002981037,"about_ca_topic_score_gemma":0.0004110021,"domain_scores_codex":[0.9996582,0.000062686,0.00003400643,0.00006301073,0.00005708523,0.0001250164],"domain_scores_gemma":[0.9998296,0.00002558637,0.00005363228,0.00001832524,0.0000286825,0.00004406755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003161882,0.00003460272,0.0009694186,0.00004531081,0.000006692976,0.00007523067,0.00001401257,0.00004094037,0.9972321,0.00003724319,0.00003643389,0.001191762],"study_design_scores_gemma":[0.0001784317,0.00114068,0.0518063,0.00003437788,0.0001404131,0.0009984709,0.0002351346,0.001849863,0.9406055,0.0002869928,0.002696859,0.00002703804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942111,0.002103007,0.001351369,0.0001000952,0.00007255388,0.00003990838,0.0003484261,0.00008781498,0.001685698],"genre_scores_gemma":[0.9940475,0.0009347606,0.001903606,0.000163601,0.00005771949,0.00006108329,0.0006726224,0.00003160846,0.002127569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764904,"threshold_uncertainty_score":0.005904138,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2085704486","doi":"10.1007/s12079-009-0084-0","title":"The lectin concanavalin‐A signals MT1‐MMP catalytic independent induction of COX‐2 through an IKKγ/NF‐κB‐dependent pathway","year":2010,"lang":"en","type":"article","venue":"Journal of Cell Communication and Signaling","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":46,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Montréal","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Concanavalin A; Lectin; NF-κB; Matrix metalloproteinase; Inflammation; Computer science; Cancer research; Medicine; Chemistry; Immunology; Biochemistry; Internal medicine; In vitro","authors":[{"name":"Asmaa Sina","is_ca":true},{"name":"Sébastien Proulx‐Bonneau","is_ca":true},{"name":"Alain Roy","is_ca":true},{"name":"Laurent Poliquin","is_ca":true},{"name":"Jian Cao","is_ca":false},{"name":"Borhane Annabi","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1165769033523747,"gpt":0.4088533024446194,"spread":0.2922763990922447,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148893,0.0004562109,0.0001786119,0.0002411427,0.0001862803,0.0003322154,0.0001286411,0.0002241976,0.0012702],"category_scores_gemma":[0.0001047808,0.0001209859,0.0003945231,0.0001727856,0.0002539014,0.0001947353,0.0001809097,0.0006751576,0.0004955725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003716695,"about_ca_system_score_gemma":0.0002996552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008266144,"about_ca_topic_score_gemma":0.001068745,"domain_scores_codex":[0.999853,0.00001876329,0.00001369689,0.000023134,0.00003946746,0.00005196367],"domain_scores_gemma":[0.9999056,0.0000108435,0.00002416563,0.00001450569,0.00001566897,0.00002920984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001092293,0.00002597152,0.0001352986,0.00004178004,0.000002776969,0.00005420105,0.000006983897,0.00002202416,0.9991354,0.00006612029,0.00002923582,0.0003710268],"study_design_scores_gemma":[0.00003043775,0.0001900494,0.01239301,0.00001105435,0.00001372277,0.0004154488,0.00004502284,0.0006781749,0.983713,0.0001240838,0.00238028,0.000005627723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864886,0.003260033,0.004352506,0.0002829199,0.000126716,0.0000695303,0.001141217,0.0001862526,0.004092033],"genre_scores_gemma":[0.9918239,0.001332918,0.00185324,0.000112317,0.00002834877,0.00006921944,0.0008888204,0.00001759685,0.00387356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0012702,"threshold_uncertainty_score":0.004249275,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1973407369","doi":"10.1016/j.freeradbiomed.2007.07.005","title":"Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F","year":2007,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo; University of Manitoba","funders":"National Cancer Institute","keywords":"Glutathione; Chemistry; Cytotoxicity; Buthionine sulfoximine; Hydrogen peroxide; Catalase; DNA damage; Reactive oxygen species; Biochemistry; Peroxidase; Hydroxyl radical; Sulfoxide; Antioxidant; Radical; DNA; Stereochemistry; In vitro; Enzyme; Organic chemistry","authors":[{"name":"Kimberley A. O’Hara","is_ca":true},{"name":"Xing Wu","is_ca":true},{"name":"Daywin Patel","is_ca":true},{"name":"Liang Hong","is_ca":true},{"name":"Jack C. Yalowich","is_ca":false},{"name":"Nan Chen","is_ca":true},{"name":"Valerie J. Goodfellow","is_ca":true},{"name":"Otunola Adedayo","is_ca":true},{"name":"Gary I. Dmitrienko","is_ca":true},{"name":"Brian B. Hasinoff","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07265312980657405,"gpt":0.4040340171229732,"spread":0.3313808873163991,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447874,0.0003173036,0.0004002105,0.0002531863,0.0003117001,0.0003200608,0.0004255342,0.000669436,0.001664005],"category_scores_gemma":[0.000290982,0.0001253751,0.0003056586,0.00008468804,0.0003638663,0.0004031317,0.0002353644,0.0003901441,0.0005155398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005146217,"about_ca_system_score_gemma":0.0002288784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006359572,"about_ca_topic_score_gemma":0.0003057063,"domain_scores_codex":[0.9998459,0.00005237625,0.000008233793,0.00002095892,0.00003103353,0.00004152749],"domain_scores_gemma":[0.9997738,0.0001004274,0.00003386817,0.00003430242,0.00003480421,0.00002278138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005384755,0.00004430016,0.0003005467,0.0001303372,0.00001261584,0.0003779884,0.00006056975,0.0004341499,0.992371,0.001650136,0.000218732,0.003861075],"study_design_scores_gemma":[0.00005319473,0.0008802867,0.002205373,0.00001038553,0.00001452632,0.0009695624,0.00004868624,0.001656712,0.9912426,0.0003785187,0.002528454,0.00001172772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749967,0.006606336,0.01009684,0.0005717482,0.00009997984,0.0001213972,0.0003470904,0.0002534265,0.00690638],"genre_scores_gemma":[0.9969181,0.0006417695,0.0005328708,0.00004329763,0.00001108389,0.00002110345,0.00007579697,0.000006309499,0.001749765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001664005,"threshold_uncertainty_score":0.005566657,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3100358749","doi":"10.1080/07391102.2020.1846622","title":"Antimicrobial activity of<i>Plumbago indica</i>and ligand screening of plumbagin against methicillin-resistant<i>Staphylococcus aureus</i>","year":2020,"lang":"en","type":"article","venue":"Journal of Biomolecular Structure and Dynamics","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"University of Sri Jayewardenepura","keywords":"Plumbagin; Antimicrobial; DNA gyrase; Staphylococcus aureus; Minimum inhibitory concentration; Chemistry; Antibacterial activity; Microbiology; Docking (animal); Traditional medicine; Biology; Bacteria; Biochemistry; Escherichia coli; Botany; Medicine","authors":[{"name":"Indeewarie Hemamali Dissanayake","is_ca":false},{"name":"Deshan Perera","is_ca":false},{"name":"Lakshika Keerthirathna","is_ca":false},{"name":"Saumya Nishanga Heendeniya","is_ca":false},{"name":"Raymond Anderson","is_ca":true},{"name":"David E. Williams","is_ca":true},{"name":"L.D.C. Peiris","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03903196942547921,"gpt":0.3391641869052981,"spread":0.3001322174798189,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007078647,0.0002770419,0.000271082,0.0001782387,0.0001196448,0.0001870401,0.0001513821,0.0001863814,0.001677278],"category_scores_gemma":[0.0001100794,0.0000634173,0.0002313575,0.0001264978,0.0001052804,0.0001326194,0.0001357875,0.0002607639,0.0002872128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102241,"about_ca_system_score_gemma":0.0001402956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004255283,"about_ca_topic_score_gemma":0.0007135331,"domain_scores_codex":[0.9999584,0.00001077772,0.000002153521,0.000009127496,0.00001314663,0.000006420183],"domain_scores_gemma":[0.9999578,0.00000987013,0.00001067505,0.000003269146,0.000008125889,0.00001019864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009748334,0.00003420738,0.000184994,0.0001697099,0.00000896682,0.00006926085,0.000008382118,0.0003802097,0.9945782,0.00004520876,0.00004026845,0.004383069],"study_design_scores_gemma":[0.00002838129,0.001526336,0.005628097,0.00002232211,0.00004533016,0.0005825214,0.00005253163,0.001974037,0.9843851,0.00008990492,0.005650702,0.00001470951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981293,0.009439251,0.003859668,0.0002316189,0.00002426448,0.0000690809,0.0003851275,0.0001379754,0.004559956],"genre_scores_gemma":[0.9909576,0.002410383,0.004401981,0.00007185105,0.00000756649,0.00001885698,0.0003779652,0.00001587001,0.001737977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677278,"threshold_uncertainty_score":0.005611062,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2049574160","doi":"10.1074/jbc.m113.457002","title":"Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan; Canadian Light Source","keywords":"Quinone; Chemistry; Cofactor; Stereochemistry; Flavin adenine dinucleotide; Reductase; Redox; Enzyme; Biochemistry","authors":[{"name":"Kevin Leung","is_ca":true},{"name":"Brian H. Shilton","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1113976887072063,"gpt":0.3869014440403148,"spread":0.2755037553331084,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008027603,0.0002129456,0.0002755745,0.00007520022,0.0001411204,0.0001802544,0.000287432,0.0002624897,0.001922737],"category_scores_gemma":[0.0001649863,0.0001468974,0.0001680787,0.00008064285,0.000150414,0.0001228472,0.0001512065,0.0004269234,0.000259497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005193455,"about_ca_system_score_gemma":0.0001576424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003059963,"about_ca_topic_score_gemma":0.004150166,"domain_scores_codex":[0.9998931,0.00001638759,0.000003476326,0.00002614081,0.00003530742,0.00002570694],"domain_scores_gemma":[0.9999353,0.00001754817,0.00001076062,0.000005578988,0.00001373806,0.00001717085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003293495,0.0000217248,0.0007709051,0.00007386667,0.00001301391,0.0001562689,0.00004325782,0.0003658867,0.9968376,0.0001010656,0.0002213104,0.001065547],"study_design_scores_gemma":[0.00009218403,0.000475819,0.02669216,0.00001284269,0.0000270524,0.0004787991,0.00007347155,0.005667469,0.9607809,0.000166543,0.005509612,0.00002320747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932762,0.001850112,0.002067427,0.0002146072,0.00002082584,0.00001037447,0.0004162175,0.0001065612,0.002037709],"genre_scores_gemma":[0.9974274,0.0003199944,0.0008881206,0.00009776512,0.00000509356,0.000004152694,0.000510934,0.000009766954,0.0007366792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003059963,"threshold_uncertainty_score":0.006432176,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2092211760","doi":"10.1016/j.ejmech.2010.05.046","title":"Design and synthesis of chloroquine analogs with anti-breast cancer property","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"NOSM University; Laurentian University; Sudbury Regional Hospital","funders":"Ontario Ministry of Research and Innovation","keywords":"Chemistry; Trifluoromethyl; Breast cancer; Amine gas treating; Cisplatin; Cancer; Cancer cell; Chloroquine; Stereochemistry; Tertiary amine; Pharmacology; Cell culture; Cancer cell lines; Cell growth; Chemical synthesis; Cancer research; Chemotherapy; In vitro; Internal medicine; Biochemistry; Medicine; Immunology; Biology; Organic chemistry; Malaria","authors":[{"name":"V. Raja Solomon","is_ca":true},{"name":"Changkun Hu","is_ca":true},{"name":"Hoyun Lee","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05930331805052082,"gpt":0.3495110839429834,"spread":0.2902077658924626,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672443,0.0003376334,0.0003213495,0.0002236553,0.000173368,0.0002105391,0.0004696133,0.0002944022,0.001967676],"category_scores_gemma":[0.0002318546,0.0001677775,0.0002205561,0.0001936542,0.0001828801,0.0002247406,0.0001941911,0.0003854528,0.0003376881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002949549,"about_ca_system_score_gemma":0.0003119141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005245414,"about_ca_topic_score_gemma":0.001025365,"domain_scores_codex":[0.99992,0.00001623633,0.00001115772,0.00001504267,0.0000133641,0.00002417382],"domain_scores_gemma":[0.999899,0.00001594502,0.00003142486,0.00001093064,0.00002078275,0.00002190261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001733989,0.0003047901,0.0006214907,0.0009228904,0.00004814561,0.001008996,0.0001456782,0.00518752,0.9402824,0.002420328,0.00101263,0.04631109],"study_design_scores_gemma":[0.0005946438,0.004215749,0.001312607,0.00003349383,0.00007740851,0.0007546654,0.00004452523,0.002505561,0.9658253,0.0002660396,0.02433545,0.00003459926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9485625,0.01020495,0.02589655,0.0004872507,0.000207193,0.0008965537,0.001473613,0.0003352231,0.0119361],"genre_scores_gemma":[0.986298,0.002647548,0.008508749,0.0001164052,0.00002488601,0.0001126097,0.0005009067,0.00001793575,0.001773026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001967676,"threshold_uncertainty_score":0.006582499,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2902749844","doi":"10.1139/bcb-2018-0310","title":"Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2–AMPK–PGC1α signaling pathway","year":2018,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"","keywords":"AMPK; Mitochondrion; Oxidative stress; PKM2; Cell biology; Apoptosis; Reactive oxygen species; Citric acid cycle; Oxidative phosphorylation; Biology; Signal transduction; AMP-activated protein kinase; Cancer research; Chemistry; Glycolysis; Biochemistry; Protein kinase A; Phosphorylation; Pyruvate kinase; Metabolism","authors":[{"name":"Bing Liu","is_ca":false},{"name":"Jiangbo Jin","is_ca":false},{"name":"Ziyu Zhang","is_ca":false},{"name":"Li Zuo","is_ca":false},{"name":"Meixiu Jiang","is_ca":false},{"name":"Caifeng Xie","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06204302198010215,"gpt":0.3379971820457495,"spread":0.2759541600656473,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006001805,0.0002714593,0.000204566,0.0002453917,0.0001270885,0.0001278607,0.0000858851,0.0001787111,0.0007986911],"category_scores_gemma":[0.00004773155,0.0000519593,0.0001836546,0.0001882198,0.0001175608,0.0001591998,0.0001108242,0.0003209025,0.0001219544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002422,"about_ca_system_score_gemma":0.0002067254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004513119,"about_ca_topic_score_gemma":0.001548689,"domain_scores_codex":[0.9999572,0.000007746521,0.000005011519,0.000006885091,0.00001055144,0.0000125794],"domain_scores_gemma":[0.9999768,0.000002819276,0.00000741517,0.000002797875,0.000003910364,0.000006318593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003246317,0.00009677446,0.0009238521,0.0001970379,0.00001951369,0.0001197941,0.00001254539,0.000206427,0.9879242,0.0001132501,0.00008924529,0.009972737],"study_design_scores_gemma":[0.000127139,0.001971669,0.01560056,0.00001674587,0.00007606143,0.0005425191,0.00005589388,0.0009788449,0.9750773,0.0001796944,0.005365009,0.000008499078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860923,0.009559871,0.002115564,0.0002689684,0.00004985,0.00003430345,0.0002337512,0.00008472027,0.001560771],"genre_scores_gemma":[0.995713,0.00280021,0.0004755357,0.00004322398,0.00000793247,0.00001391151,0.0001775373,0.000003559244,0.0007651637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007986911,"threshold_uncertainty_score":0.002671897,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1968042102","doi":"10.1007/s11033-008-9356-7","title":"Dual role of shikonin in early and late stages of collagen type II arthritis","year":2008,"lang":"en","type":"article","venue":"Molecular Biology Reports","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Arthritis; Cartilage; Messenger RNA; Tumor necrosis factor alpha; Cytokine; Type II collagen; Medicine; Collagen-induced arthritis; Interleukin; Immunology; Inflammation; Endocrinology; Andrology; Internal medicine; Chemistry; Anatomy; Biochemistry","authors":[{"name":"Qiaomei Dai","is_ca":false},{"name":"Jiao-qiao FANG","is_ca":true},{"name":"Fengshan Zhang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04702096478622669,"gpt":0.3705367066876031,"spread":0.3235157419013764,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639844,0.0003446563,0.0002657429,0.0004193042,0.0001743753,0.0003713538,0.0001555267,0.0003163042,0.0009883139],"category_scores_gemma":[0.0001459419,0.000146193,0.0002482914,0.0001287362,0.0003139515,0.0005486669,0.0002355285,0.0004620529,0.0002807948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881045,"about_ca_system_score_gemma":0.0002592097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003647463,"about_ca_topic_score_gemma":0.0005975168,"domain_scores_codex":[0.9998777,0.00002385072,0.00001171899,0.0000154897,0.00002300435,0.00004821596],"domain_scores_gemma":[0.9997889,0.00002857779,0.00004904413,0.00002028143,0.00004255075,0.00007068662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000616057,0.00001987486,0.00101069,0.00006237056,0.000005215136,0.0002142483,0.00001984208,0.00002158691,0.9951024,0.0003080157,0.0000275917,0.002592133],"study_design_scores_gemma":[0.0001068521,0.001503303,0.08531987,0.00003510193,0.00009700646,0.002104882,0.0003402696,0.0005541459,0.9038687,0.001197548,0.004849756,0.00002241804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976401,0.01749547,0.00301458,0.0002195997,0.00007904738,0.00002171441,0.0001681236,0.00007595041,0.002524422],"genre_scores_gemma":[0.9943961,0.001959573,0.0009517429,0.00003425268,0.00004213775,0.00001314784,0.0001188292,0.000007432295,0.002476956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009883139,"threshold_uncertainty_score":0.00330621,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1846814999","doi":"10.1016/j.tiv.2015.09.029","title":"Antigenotoxic, anti-photogenotoxic and antioxidant activities of natural naphthoquinone shikonin and acetylshikonin and Arnebia euchroma callus extracts evaluated by the umu-test and EPR method","year":2015,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Warszawski Uniwersytet Medyczny; University of Saskatchewan","keywords":"Genotoxicity; Chemistry; DPPH; Antioxidant; Cytotoxicity; Pharmacology; Apoptosis; Traditional medicine; Biochemistry; In vitro; Organic chemistry; Biology; Medicine; Toxicity","authors":[{"name":"Agata Skrzypczak","is_ca":false},{"name":"Natalia Przystupa","is_ca":false},{"name":"Anna Zgadzaj","is_ca":false},{"name":"Andrzej Parzonko","is_ca":false},{"name":"Katarzyna Sykłowska-Baranek","is_ca":false},{"name":"Katarzyna Paradowska","is_ca":false},{"name":"Grzegorz Nałęcz‐Jawecki","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09518259978800049,"gpt":0.4163275304472309,"spread":0.3211449306592304,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433047,0.0003629812,0.0001528218,0.0003881224,0.0001468666,0.00008581698,0.0001432604,0.0001662888,0.0009923801],"category_scores_gemma":[0.0001099166,0.0001065403,0.0002193672,0.0002255124,0.0001786344,0.0001981833,0.0001290139,0.0002155265,0.0001099672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002458,"about_ca_system_score_gemma":0.0001858944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009070331,"about_ca_topic_score_gemma":0.001263097,"domain_scores_codex":[0.9999222,0.00001866212,0.000008087562,0.000009811612,0.00002266509,0.00001857873],"domain_scores_gemma":[0.9998816,0.00003037247,0.0000244787,0.00001160761,0.00002930563,0.00002258994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002525884,0.00003855698,0.0003442554,0.00004936514,0.000007376927,0.00002681557,0.00002668493,0.0000847742,0.9977733,0.00007340325,0.000009329792,0.001313402],"study_design_scores_gemma":[0.0000152207,0.0007788454,0.007480483,0.00000437321,0.00003517572,0.0001096417,0.00003596157,0.0002810911,0.99073,0.00005014587,0.0004742545,0.000004810999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968398,0.001211226,0.0009971842,0.0000183844,0.00000815263,0.00001041564,0.0001275798,0.00001335645,0.000773969],"genre_scores_gemma":[0.9970642,0.0006198157,0.0006754812,0.00001451721,0.000005007921,0.000009496007,0.000215545,0.000003678557,0.001392364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009923801,"threshold_uncertainty_score":0.00331986,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2105546486","doi":"10.1128/iai.68.9.5462-5465.2000","title":"Role of Inducible Nitric Oxide Synthase in Resistance to<i>Mycobacterium leprae</i>in Mice","year":2000,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Mycobacterium leprae; Leprosy; Nitric oxide synthase; Biology; Immunity; Nitric oxide; Microbiology; Immunology; Mycobacterium; Bacteria; Immune system; Genetics","authors":[{"name":"Linda B. Adams","is_ca":false},{"name":"C. K. Job","is_ca":true},{"name":"James L. Krahenbuhl","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05422806203598708,"gpt":0.3700707771236951,"spread":0.3158427150877081,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004913133,0.000487916,0.0003733191,0.0007628204,0.0002840623,0.0006454145,0.0004428992,0.0008585746,0.001143736],"category_scores_gemma":[0.0002364986,0.0004418603,0.0004510797,0.0001637049,0.0007816859,0.0004083469,0.0002486757,0.001518416,0.0004322535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004667422,"about_ca_system_score_gemma":0.0003746518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006090884,"about_ca_topic_score_gemma":0.0007100577,"domain_scores_codex":[0.999647,0.00009079763,0.00003690248,0.00007064464,0.00005810726,0.00009640538],"domain_scores_gemma":[0.9993917,0.00009568637,0.0002149562,0.00005705613,0.0000346725,0.0002059903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00086811,0.000188924,0.0004278317,0.00003744133,0.000008160243,0.0001075065,0.0000402344,0.00009838153,0.9965608,0.0004183397,0.00005707597,0.00118734],"study_design_scores_gemma":[0.0003618225,0.002467913,0.007449422,0.0000518081,0.00005726223,0.001037625,0.0001248584,0.001520009,0.9828068,0.0004951399,0.003604852,0.00002251619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99224,0.001936574,0.002535326,0.0004781597,0.00004946221,0.00006603006,0.0005850805,0.000193589,0.001915769],"genre_scores_gemma":[0.9914078,0.001102568,0.003044579,0.0001932154,0.00001945195,0.0001042186,0.0004983292,0.00007006833,0.003559648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143736,"threshold_uncertainty_score":0.003826141,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2062642760","doi":"10.1039/c4ra11940a","title":"Synthesis of novel dispiropyrrolothiazoles by three-component 1,3-dipolar cycloaddition and evaluation of their antimycobacterial activity","year":2014,"lang":"en","type":"article","venue":"RSC Advances","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Sherbrooke","funders":"Compute Canada","keywords":"Antimycobacterial; Component (thermodynamics); 1,3-Dipolar cycloaddition; Cycloaddition; Chemistry; Combinatorial chemistry; Stereochemistry; Organic chemistry; Mycobacterium tuberculosis; Medicine; Tuberculosis; Physics","authors":[{"name":"Saoussen Haddad","is_ca":false},{"name":"Sarra Boudriga","is_ca":false},{"name":"François Porzio","is_ca":true},{"name":"Armand Soldera","is_ca":true},{"name":"Moheddine Askri","is_ca":false},{"name":"Dharmarajan Sriram","is_ca":false},{"name":"Perumal Yogeeswari","is_ca":false},{"name":"Michael Knorr","is_ca":false},{"name":"Yoann Rousselin","is_ca":false},{"name":"Marek M. Kubicki","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08067299642632356,"gpt":0.385601262345021,"spread":0.3049282659186975,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009018205,0.0003752254,0.000265266,0.0001843365,0.0001607764,0.0001781544,0.00033802,0.0002580219,0.001784466],"category_scores_gemma":[0.00009861046,0.0001251631,0.00021329,0.0002584998,0.0001096854,0.000129381,0.0001558193,0.0002985365,0.0005342631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002467767,"about_ca_system_score_gemma":0.0002344729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005996305,"about_ca_topic_score_gemma":0.002268682,"domain_scores_codex":[0.9999396,0.000006459607,0.000005597788,0.00001142526,0.00001976048,0.00001713931],"domain_scores_gemma":[0.9999689,0.000003041267,0.000009622527,0.000003623635,0.000006463919,0.000008373937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002212957,0.0001174122,0.0001940733,0.0004955619,0.00002317537,0.0005084239,0.0000539492,0.0009812502,0.9803696,0.0006794167,0.0004297464,0.01592608],"study_design_scores_gemma":[0.000118755,0.001934304,0.002215744,0.0000205145,0.00006508829,0.0005595364,0.00003044564,0.002119513,0.980388,0.0001209524,0.01240428,0.00002279058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620562,0.00697936,0.01541569,0.0002523652,0.0001166996,0.0005613751,0.001724881,0.0002452501,0.01264814],"genre_scores_gemma":[0.979721,0.005123136,0.01049795,0.00007661397,0.00001897541,0.000124463,0.0008388563,0.00002016226,0.003579007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784466,"threshold_uncertainty_score":0.005969644,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2341723586","doi":"10.1021/acs.biochem.5b00884","title":"Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":38,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ethidium bromide; Chemistry; Acridine orange; Intercalation (chemistry); DNA; Stereochemistry; Quinone; Biochemistry; Apoptosis; Organic chemistry","authors":[{"name":"Kevin Leung","is_ca":true},{"name":"Brian H. Shilton","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2022948895073023,"gpt":0.4467908554356698,"spread":0.2444959659283675,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545395,0.0003197418,0.0003919153,0.0001634965,0.0001607367,0.0002549262,0.0003459309,0.0003670884,0.001297065],"category_scores_gemma":[0.0005232744,0.000197164,0.0002259157,0.0001630684,0.0002187439,0.0002160452,0.0002793409,0.0004317066,0.0002716232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004347186,"about_ca_system_score_gemma":0.0001835737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001485661,"about_ca_topic_score_gemma":0.001724749,"domain_scores_codex":[0.9996588,0.000078126,0.00002416937,0.00008592894,0.00009389186,0.00005901064],"domain_scores_gemma":[0.9997876,0.00006924618,0.00004551868,0.00001797773,0.00004390655,0.00003581085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130106,0.00003202459,0.0002126577,0.00008521204,0.00002013878,0.00002245127,0.000031025,0.0002676149,0.9975932,0.00007198472,0.00005138823,0.00149931],"study_design_scores_gemma":[0.00002622651,0.0004562369,0.00142805,0.000007205256,0.00001895611,0.00009071987,0.00002509472,0.001732239,0.9927484,0.0000300073,0.003427638,0.000009242014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871984,0.004219435,0.006065357,0.0001254903,0.00003827058,0.00006259712,0.0001976221,0.00007484254,0.002018021],"genre_scores_gemma":[0.9920675,0.0009618032,0.004363644,0.0001258779,0.000009832646,0.00003942454,0.0004587828,0.00001441451,0.001958742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001485661,"threshold_uncertainty_score":0.004339099,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1483346783","doi":"10.1002/ptr.3503","title":"Shikonin Derivatives Protect Immune Organs from Damage and Promote Immune Responses <i>In Vivo</i> in Tumour‐bearing Mice","year":2011,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":38,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Department of Science and Technology of Jilin Province; University of Manitoba","keywords":"Immune system; CD19; Lymphocyte; Biology; Immunology; In vivo; Pharmacology; Natural killer cell; Cancer research; In vitro; Cytotoxic T cell; Biochemistry","authors":[{"name":"Long Su","is_ca":false},{"name":"Yan GuangZhi","is_ca":false},{"name":"Guan BaoJie","is_ca":false},{"name":"Wei Xu","is_ca":false},{"name":"Yang Zhang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2805862298595079,"gpt":0.4663316924170993,"spread":0.1857454625575914,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283075,0.0006567395,0.0003779003,0.000415087,0.000126786,0.0002208397,0.0001896758,0.0003143148,0.001013582],"category_scores_gemma":[0.00008758155,0.0001887933,0.0003322053,0.0001667806,0.00027349,0.000295807,0.0001271828,0.0008035995,0.0004129355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220583,"about_ca_system_score_gemma":0.0002181318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004287597,"about_ca_topic_score_gemma":0.0006576568,"domain_scores_codex":[0.9998745,0.00002152323,0.00001289087,0.00002240176,0.00002503971,0.00004370636],"domain_scores_gemma":[0.9998559,0.00002075614,0.00004451361,0.00001704117,0.00001231708,0.00004955398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005449744,0.0001079148,0.0001262743,0.00003520168,0.000005149484,0.00003140562,0.0000131107,0.00006628765,0.9979078,0.00003563793,0.00002714973,0.001099202],"study_design_scores_gemma":[0.0001175817,0.004235783,0.003254919,0.00000876152,0.000025148,0.0001447383,0.00002644552,0.0005492051,0.9904619,0.00003907019,0.00113098,0.000005388784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956985,0.00156645,0.0009629039,0.00009073599,0.00003004107,0.00003572879,0.0004174003,0.0001097998,0.001088396],"genre_scores_gemma":[0.9936157,0.001504933,0.001274527,0.0000749379,0.00002109926,0.00006067505,0.0007803099,0.00002711585,0.002640729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013582,"threshold_uncertainty_score":0.003390729,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2088983187","doi":"10.1016/j.bmc.2008.06.023","title":"The discovery of small molecule chemical probes of Bcl-XL and Mcl-1","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":36,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Steacie Institute for Molecular Sciences; Biotechnology Research Institute; McGill University; Ontario Institute for Cancer Research","funders":"Broad Institute; Abbott Laboratories","keywords":"Chemistry; Small molecule; In silico; Molecule; Chemical library; Scaffold; Combinatorial chemistry; Stereochemistry; Bcl-xL; Drug discovery; Biophysics; Biochemistry; Organic chemistry; Database","authors":[{"name":"Michaël Prakesch","is_ca":true},{"name":"A. Yu. Denisov","is_ca":true},{"name":"Marwen Naïm","is_ca":true},{"name":"Kalle Gehring","is_ca":true},{"name":"Prabhat Arya","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08559728218779089,"gpt":0.3535175244373098,"spread":0.2679202422495189,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000372039,0.0003749777,0.0002186857,0.0003657338,0.0002304955,0.0004409077,0.0004514266,0.0004708814,0.002487006],"category_scores_gemma":[0.0004103833,0.0002345901,0.0001907682,0.0001609276,0.0003607274,0.0005092783,0.0003646629,0.001130974,0.0003888922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005672451,"about_ca_system_score_gemma":0.0002824576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918772,"about_ca_topic_score_gemma":0.0006896973,"domain_scores_codex":[0.999921,0.00001636196,0.000003088028,0.00001413872,0.00002274496,0.00002260986],"domain_scores_gemma":[0.9998926,0.00003817888,0.00002232436,0.000008054311,0.00001520242,0.00002359754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005384302,0.0001566787,0.0002432915,0.0001907812,0.00002035972,0.0001720308,0.0000685748,0.0007843795,0.9516921,0.007812462,0.001242508,0.03707844],"study_design_scores_gemma":[0.000183218,0.0008955817,0.0005980457,0.00001443285,0.0000203811,0.000282453,0.00002797957,0.001582726,0.9752738,0.001077065,0.02002789,0.00001644114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8691919,0.03706517,0.06370505,0.005237153,0.0008081825,0.0004041094,0.001098256,0.0008148548,0.02167541],"genre_scores_gemma":[0.9650792,0.009631872,0.01393695,0.001036879,0.0001262702,0.0001700206,0.0005971868,0.00003059094,0.009390926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002487006,"threshold_uncertainty_score":0.008319855,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2075417276","doi":"10.1139/v05-121","title":"Ambident reactivity of phenoxyl radicals in DNA adduction","year":2005,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":35,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"National Institutes of Health; University of Guelph","keywords":"Chemistry; Radical; Deoxyguanosine; Reactivity (psychology); Photochemistry; Adduct; Peroxide; Reactive oxygen species; Peroxidase; Redox; Organic chemistry; Biochemistry; Enzyme","authors":[{"name":"Richard A. Manderville","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07732918907146771,"gpt":0.3796697182244986,"spread":0.3023405291530309,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002897517,0.0004785278,0.0002478042,0.0007126714,0.000211989,0.0003317097,0.0002820586,0.0004454428,0.0008980476],"category_scores_gemma":[0.0002916761,0.0001237214,0.0001907848,0.000646401,0.000373874,0.0003159193,0.0002365604,0.0004362414,0.0002985394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004356526,"about_ca_system_score_gemma":0.0003430455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001976241,"about_ca_topic_score_gemma":0.002218884,"domain_scores_codex":[0.999801,0.00003629758,0.00001112908,0.00004510032,0.00008172035,0.00002485044],"domain_scores_gemma":[0.9998059,0.00005778314,0.00005756566,0.000006394696,0.00006029333,0.0000120944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002148551,0.00008567519,0.005704641,0.007566212,0.0001605788,0.0010506,0.0003089699,0.003086586,0.768151,0.00913691,0.0016854,0.2028486],"study_design_scores_gemma":[0.00001524023,0.0007154749,0.02185014,0.0004907934,0.0002160587,0.00252114,0.0003218016,0.00180717,0.8080751,0.006357394,0.1575607,0.00006894629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1516821,0.8161958,0.01654629,0.0007040667,0.000533737,0.00006431927,0.0002684594,0.0001003531,0.01390485],"genre_scores_gemma":[0.5926762,0.3920489,0.005298085,0.0003260311,0.0002363977,0.00003909132,0.000196654,0.00001437075,0.009164258],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001976241,"threshold_uncertainty_score":0.003929496,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2994119889","doi":"10.1002/chem.201904607","title":"An Activatable Photosensitizer Targeting Human NAD(P)H: Quinone Oxidoreductase 1","year":2019,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":35,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"NAD+ kinase; Photosensitizer; Quinone; Oxidoreductase; Chemistry; Stereochemistry; Photochemistry; Biochemistry; Enzyme","authors":[{"name":"Elyse M. Digby","is_ca":true},{"name":"Oleg Sadovski","is_ca":true},{"name":"Andrew A. Beharry","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07695641304058672,"gpt":0.3950037925198306,"spread":0.3180473794792439,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008085499,0.0002124976,0.0001136335,0.00007638887,0.00006348749,0.0001333887,0.0001600906,0.0002598882,0.0007018403],"category_scores_gemma":[0.00005588637,0.00007709492,0.00009323587,0.00006832376,0.0001230462,0.0001154007,0.0001069819,0.0002499672,0.0001590623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417794,"about_ca_system_score_gemma":0.0001037903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657395,"about_ca_topic_score_gemma":0.0006272562,"domain_scores_codex":[0.9999608,0.000004929104,0.000001660149,0.00001529325,0.000008617752,0.000008718147],"domain_scores_gemma":[0.9999803,0.000005380839,0.000006150498,0.000001971903,0.000002328696,0.000003757391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002804029,0.00001318834,0.00003055876,0.00002139578,0.000001298474,0.00001218984,0.000006559811,0.00006572664,0.9987693,0.0000689174,0.00002600708,0.0009567367],"study_design_scores_gemma":[0.00000800548,0.0001671324,0.000478265,0.000001575038,0.000004292193,0.00006397007,0.00000411438,0.0004721731,0.9969393,0.00001404628,0.001845538,0.000001612926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861951,0.002395334,0.008562349,0.000162104,0.00003584677,0.00005973838,0.000163628,0.0001057058,0.002320281],"genre_scores_gemma":[0.9932019,0.000787292,0.002904016,0.00004703954,0.000006650902,0.00002324955,0.0001951807,0.000006938312,0.002827673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007018403,"threshold_uncertainty_score":0.002347887,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2027177342","doi":"10.1038/sj.bjc.6602171","title":"Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo","year":2004,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":35,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"National Cancer Institute; Canadian Institutes of Health Research; American Institute for Cancer Research","keywords":"Dicoumarol; In vivo; Mitomycin C; Pharmacology; Toxicity; Ratón; NAD+ kinase; In vitro; Chemistry; Biology; Enzyme; Biochemistry; Medicine; Immunology; Internal medicine","authors":[{"name":"Asher Begleiter","is_ca":true},{"name":"Marsha K. Leith","is_ca":true},{"name":"James A. Thliveris","is_ca":true},{"name":"Tyler Digby","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08621952986380309,"gpt":0.4214474722948882,"spread":0.3352279424310851,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867072,0.0003055373,0.0004091544,0.0002828311,0.0001299335,0.0002090479,0.0001426413,0.00029223,0.001527176],"category_scores_gemma":[0.0001714963,0.0001744077,0.000195881,0.0002044313,0.0001932607,0.0001501589,0.0001538874,0.0005890005,0.0003139751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003435978,"about_ca_system_score_gemma":0.0002521639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001747036,"about_ca_topic_score_gemma":0.00334291,"domain_scores_codex":[0.9998592,0.00002838654,0.00001101384,0.0000314933,0.00003200713,0.00003780984],"domain_scores_gemma":[0.9998177,0.00004161743,0.00003902708,0.00002520953,0.00002222269,0.00005440457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003029394,0.00007351045,0.000147767,0.00002577108,0.000005050337,0.00001488016,0.00001109002,0.0000477955,0.998377,0.00001972572,0.0000475577,0.0009270499],"study_design_scores_gemma":[0.00007339247,0.003139556,0.005109484,0.000005788586,0.00002598905,0.0001442954,0.0000194902,0.0005455779,0.9889242,0.00001626466,0.001991782,0.000004181332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956245,0.001662666,0.001142546,0.0001066301,0.00004602892,0.00005203637,0.0003031762,0.00008981892,0.0009725951],"genre_scores_gemma":[0.9955486,0.0009802564,0.0011454,0.00003644102,0.00001632335,0.00004172621,0.0005459256,0.00001912483,0.001666136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747036,"threshold_uncertainty_score":0.005108953,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2995594743","doi":"10.1038/s41598-019-55839-8","title":"Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":34,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"University of Delhi; Council of Scientific and Industrial Research, India; Indian Council of Medical Research","keywords":"Noscapine; Microtubule; Computational biology; Pharmacology; Bioinformatics; Chemistry; Biology; Genetics; Alkaloid; Stereochemistry","authors":[{"name":"Vartika Tomar","is_ca":true},{"name":"Neeraj Kumar","is_ca":false},{"name":"Ravi Tomar","is_ca":false},{"name":"Damini Sood","is_ca":false},{"name":"Neerupma Dhiman","is_ca":false},{"name":"Sujata K. Dass","is_ca":false},{"name":"Satya Prakash","is_ca":true},{"name":"Jitender Madan","is_ca":false},{"name":"Ramesh Chandra","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.176212714779303,"gpt":0.4437071556216723,"spread":0.2674944408423694,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000885038,0.0002217584,0.0001897968,0.0001506109,0.00008854323,0.000120383,0.0002146007,0.0001862183,0.001760129],"category_scores_gemma":[0.0001100965,0.00006244399,0.0001688288,0.0001161334,0.00009053393,0.0001565289,0.0001335243,0.0003588223,0.0002227948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001047143,"about_ca_system_score_gemma":0.00008628595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000260456,"about_ca_topic_score_gemma":0.0009703679,"domain_scores_codex":[0.9999503,0.00001156524,0.000004499279,0.000008340967,0.00001633089,0.000008971289],"domain_scores_gemma":[0.9999372,0.000007450069,0.00001619028,0.000005274483,0.00001685988,0.00001704551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004162871,0.0001667634,0.0002329008,0.0004685308,0.00002175273,0.000203231,0.00002490944,0.0005652168,0.9893494,0.0001502685,0.0002205,0.008180215],"study_design_scores_gemma":[0.00008331618,0.006266002,0.003063401,0.00004144741,0.00006843657,0.0005605832,0.00005487345,0.001273271,0.9740074,0.00007495814,0.01448909,0.0000171463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726443,0.01774153,0.002202909,0.0002130151,0.0001572412,0.0001294083,0.000749129,0.00007007998,0.006092331],"genre_scores_gemma":[0.9891343,0.004993433,0.001589604,0.00009050509,0.0000302224,0.00003980593,0.0004562953,0.000006881507,0.003659048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001760129,"threshold_uncertainty_score":0.005888224,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}