{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":1349,"total_is_capped":false,"direct_labels_cover":4,"predictions_cover":1349,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"73f209f530c7","filters":{"topic":"Chemical Synthesis and Analysis"}},"results":[{"id":"W2041593863","doi":"10.1038/nchem.1062","title":"Contemporary strategies for peptide macrocyclization","year":2011,"lang":"en","type":"review","venue":"Nature Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1068,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Peptide; Cyclic peptide; Combinatorial chemistry; Drug discovery; Ring (chemistry); Molecule; Nanotechnology; Small molecule; Nanomaterials; Biochemistry; Organic chemistry","authors":[{"name":"CHRISTOPHER J. BRANFORD WHITE","is_ca":true},{"name":"Andrei K. Yudin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.028077322387928,"gpt":0.3168296954450466,"spread":0.2887523730571186,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001215749,0.001474578,0.001297467,0.001400776,0.0005810141,0.001354648,0.001600669,0.001147362,0.003258374],"category_scores_gemma":[0.001019651,0.0007072988,0.0004159763,0.001984478,0.001635502,0.002656622,0.001667798,0.002707675,0.002723721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00114363,"about_ca_system_score_gemma":0.0009899235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007027765,"about_ca_topic_score_gemma":0.001243626,"domain_scores_codex":[0.9995973,0.00005692839,0.00004108411,0.00008543616,0.0001517615,0.00006742983],"domain_scores_gemma":[0.9996701,0.0001568883,0.00004759805,0.00003024576,0.00006409368,0.00003103379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008496374,0.00009875885,0.00009725054,0.007194571,0.00004710297,0.0002434044,0.00009237497,0.001917252,0.01480368,0.02976207,0.01907209,0.9265865],"study_design_scores_gemma":[0.00002471457,0.0001389399,0.0002059002,0.0007583783,0.00003648301,0.0006598872,0.00004153328,0.0004626874,0.01083586,0.009856446,0.976949,0.00003013061],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007700352,0.9870581,0.005786804,0.0003835663,0.0005913382,0.00002244989,0.0000343589,0.00007600823,0.005277343],"genre_scores_gemma":[0.005037822,0.9868156,0.003703273,0.0004416985,0.0003935125,0.00006161755,0.00007499202,0.00002093802,0.00345042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003258374,"threshold_uncertainty_score":0.01090038,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2113450820","doi":"10.1039/c4sc03089c","title":"Macrocycles: lessons from the distant past, recent developments, and future directions","year":2014,"lang":"en","type":"article","venue":"Chemical Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":488,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Toronto Public Health","funders":"Canadian Institutes of Health Research; Québec Consortium for Drug Discovery; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke; GlaxoSmithKline; University of Toronto; AstraZeneca","keywords":"The Renaissance; Nanotechnology; Cognitive science; Computer science; Combinatorial chemistry; Chemistry; Psychology; Materials science; History","authors":[{"name":"Andrei K. Yudin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007334368554090918,"gpt":0.2417139205905678,"spread":0.2343795520364769,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002334763,0.000592865,0.0008970594,0.0009544761,0.0007651413,0.002402261,0.0009844407,0.001774612,0.003320931],"category_scores_gemma":[0.001845882,0.0002890564,0.0003342454,0.0009333859,0.003611064,0.007500571,0.001456343,0.003804015,0.001204079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001532778,"about_ca_system_score_gemma":0.001039799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089749,"about_ca_topic_score_gemma":0.002799964,"domain_scores_codex":[0.9996142,0.0001037237,0.00003591853,0.0000753852,0.0001172247,0.00005345112],"domain_scores_gemma":[0.9988486,0.0006523511,0.00008664318,0.00006776048,0.0001589194,0.0001856764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002979476,0.0001842881,0.000481996,0.007759911,0.00006028968,0.0008330512,0.001159595,0.001568864,0.006265833,0.191994,0.0619876,0.7274066],"study_design_scores_gemma":[0.00001731876,0.0001855442,0.0003425374,0.00124773,0.00001787007,0.0007618732,0.0005657139,0.0002445015,0.001450655,0.06504783,0.9300834,0.00003510832],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007424858,0.9891215,0.0006006638,0.00569582,0.001013235,0.00000265859,0.00001247306,0.00001278127,0.002798252],"genre_scores_gemma":[0.009555446,0.9825514,0.0009059346,0.003017049,0.002061412,0.00001071146,0.00001585958,0.00001163013,0.001870641],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003320931,"threshold_uncertainty_score":0.01234752,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2003071531","doi":"10.1021/ja064315b","title":"Highly Efficient Oxidative Amidation of Aldehydes with Amine Hydrochloride Salts","year":2006,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":439,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Citation; Computer science; Amine gas treating; Hydrochloride; Chemistry; Information retrieval; Library science; World Wide Web; Organic chemistry","authors":[{"name":"Woo‐Jin Yoo","is_ca":true},{"name":"Chao‐Jun Li","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003179665295686817,"gpt":0.2071886689692243,"spread":0.2040090036735375,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007371798,0.001156074,0.0005982222,0.0004240927,0.0002276266,0.0002202802,0.0006983082,0.0005093837,0.0008796842],"category_scores_gemma":[0.0004176421,0.0003890935,0.0004738957,0.0002130411,0.0002618865,0.0004622421,0.0006138775,0.001014836,0.0006098804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272672,"about_ca_system_score_gemma":0.0003231954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004182541,"about_ca_topic_score_gemma":0.001259499,"domain_scores_codex":[0.999495,0.00008170369,0.00005824683,0.00008650823,0.0001384301,0.0001400024],"domain_scores_gemma":[0.9997346,0.00003908689,0.00006555142,0.00003643424,0.00006404478,0.00006038218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007864892,0.00003987128,0.00009921809,0.0001290861,0.00002383274,0.0002073564,0.00003712959,0.0001304145,0.9932955,0.0002914277,0.0001789479,0.005488596],"study_design_scores_gemma":[0.00001099726,0.0001742866,0.0002722265,0.000003486568,0.00001058848,0.0001539719,0.000005665031,0.0002550691,0.9974489,0.00002902749,0.001628863,0.000006979732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8548447,0.007096057,0.1264653,0.0004866386,0.0003783503,0.0004200698,0.0008783955,0.001229418,0.008201003],"genre_scores_gemma":[0.9618959,0.002965083,0.03050451,0.0000813377,0.00005130854,0.00008567819,0.0005903905,0.00005643972,0.003769345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156074,"threshold_uncertainty_score":0.003898621,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2130595127","doi":"10.1021/ar030252f","title":"Ionic-Liquid-Supported Synthesis:  A Novel Liquid-Phase Strategy for Organic Synthesis","year":2006,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":433,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Ionic liquid; Reagent; Chemistry; Solubility; Organic synthesis; Phase (matter); Aqueous solution; Catalysis; Combinatorial chemistry; Ionic bonding; Aqueous two-phase system; Organic chemistry; Chemical engineering; Ion","authors":[{"name":"Weishi Miao","is_ca":true},{"name":"Tak Hang Chan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04784632062839733,"gpt":0.3706074684172895,"spread":0.3227611477888921,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002588291,0.0006631564,0.0004471852,0.0004863806,0.0002267159,0.0005407932,0.001006719,0.000566567,0.001872032],"category_scores_gemma":[0.0002642353,0.0002715196,0.0003996161,0.0004396738,0.0003037772,0.0006020034,0.0005175501,0.0009164953,0.001783126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004175577,"about_ca_system_score_gemma":0.000477898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002941472,"about_ca_topic_score_gemma":0.000492294,"domain_scores_codex":[0.9997378,0.00003898286,0.00002751091,0.00005463043,0.0001024782,0.00003860637],"domain_scores_gemma":[0.9999005,0.00002124594,0.00002174117,0.00001657633,0.00002069844,0.0000192298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004727765,0.00006499692,0.00003891558,0.0002953868,0.00001225745,0.0001516586,0.00002724553,0.0003570163,0.9735771,0.001745372,0.0004346339,0.02324819],"study_design_scores_gemma":[0.00002184727,0.0001252485,0.00008405145,0.0000151846,0.00001500532,0.0002499973,0.000006439911,0.001605685,0.9757415,0.0002937696,0.02182344,0.00001777665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2688178,0.02789845,0.6579312,0.001377545,0.001021502,0.000918675,0.001662266,0.004118854,0.0362536],"genre_scores_gemma":[0.6116931,0.01745047,0.3529596,0.0006534744,0.0002448032,0.0006773126,0.001533443,0.0004705862,0.01431723],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001872032,"threshold_uncertainty_score":0.0062626,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2071418326","doi":"10.1021/ja808332k","title":"Palladium-Catalyzed Direct Arylation of Azine and Azole <i>N</i>-Oxides: Reaction Development, Scope and Applications in Synthesis","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":414,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"Amgen","keywords":"Azine; Chemistry; Regioselectivity; Azole; Combinatorial chemistry; Catalysis; Palladium; Ligand (biochemistry); Organic chemistry; Antifungal; Receptor","authors":[{"name":"Louis‐Charles Campeau","is_ca":true},{"name":"David R. Stuart","is_ca":true},{"name":"Jean‐Philippe Leclerc","is_ca":true},{"name":"Mégan Bertrand-Laperle","is_ca":true},{"name":"Elisia Villemure","is_ca":true},{"name":"Ho‐Yan Sun","is_ca":true},{"name":"Sandrine Lasserre","is_ca":true},{"name":"Nicolas Guimond","is_ca":true},{"name":"Melanie Lecavallier","is_ca":true},{"name":"Keith Fagnou","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00550775364641084,"gpt":0.2303167646091795,"spread":0.2248090109627687,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022984,0.0006646643,0.0002686977,0.0001714567,0.0002374974,0.0002388257,0.000474804,0.0002968023,0.001110336],"category_scores_gemma":[0.0001675145,0.0002351094,0.0002557981,0.0001836984,0.000206922,0.0003843071,0.0003452446,0.0007120903,0.0005512441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551093,"about_ca_system_score_gemma":0.0002795111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004285686,"about_ca_topic_score_gemma":0.001396732,"domain_scores_codex":[0.9999009,0.00001499584,0.0000101842,0.00002587767,0.00002457542,0.00002349415],"domain_scores_gemma":[0.9999498,0.0000126513,0.0000140698,0.00000500691,0.000008736296,0.000009734422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001313149,0.00006367281,0.0002302564,0.0005064541,0.00002085136,0.0002507739,0.00007323422,0.0004778643,0.9750368,0.0008632359,0.0003792917,0.02196636],"study_design_scores_gemma":[0.00001219855,0.000224668,0.0002913176,0.000006850185,0.00001387436,0.000316745,0.00001334715,0.0003440045,0.9924192,0.000125454,0.006223612,0.00000884967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7642221,0.02735255,0.1635036,0.0007076258,0.0003230972,0.0006443079,0.001076759,0.000739275,0.04143072],"genre_scores_gemma":[0.9297462,0.02105197,0.03673356,0.0001466204,0.00004853656,0.0001743516,0.000585874,0.00007723096,0.01143559],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001110336,"threshold_uncertainty_score":0.003714502,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2012306698","doi":"10.1002/anie.200705468","title":"Direct and Waste‐Free Amidations and Cycloadditions by Organocatalytic Activation of Carboxylic Acids at Room Temperature","year":2008,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":386,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Chemistry; Organic chemistry; Carboxylic acid","authors":[{"name":"Raed M. Al‐Zoubi","is_ca":true},{"name":"Olivier Marion","is_ca":true},{"name":"Dennis G. Hall","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005503239741712978,"gpt":0.2068550995058878,"spread":0.2013518597641748,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004349005,0.0005577913,0.0002242606,0.0003277168,0.0002282419,0.0003948689,0.0004399807,0.0004189378,0.001973015],"category_scores_gemma":[0.000271769,0.0002699734,0.0003006677,0.000236291,0.000357856,0.0005642519,0.0005549663,0.0006705894,0.0007952584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394046,"about_ca_system_score_gemma":0.0002625838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001559163,"about_ca_topic_score_gemma":0.0004773692,"domain_scores_codex":[0.9996699,0.00004338796,0.00002363083,0.00006877342,0.00007602679,0.0001183098],"domain_scores_gemma":[0.9998797,0.00002187551,0.00003569225,0.00002527585,0.0000138391,0.00002366205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002600375,0.00003276583,0.0001006613,0.0001739466,0.00001497509,0.0001128134,0.00006931111,0.0002102984,0.9886391,0.002391051,0.0002795484,0.00771553],"study_design_scores_gemma":[0.00001525045,0.0001484454,0.0001903314,0.000004046861,0.000006912177,0.0001262835,0.000008640197,0.000194531,0.996532,0.0001391566,0.002624186,0.00001026839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9179211,0.006913649,0.05098231,0.0002616036,0.0002088661,0.0001440291,0.0006050541,0.0005621805,0.02240119],"genre_scores_gemma":[0.9852023,0.002010491,0.008420084,0.00005373232,0.00003158857,0.00006541951,0.000275134,0.00005970961,0.003881721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001973015,"threshold_uncertainty_score":0.00660038,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2104936679","doi":"10.1002/anie.200901317","title":"Chemoselectivity and the Curious Reactivity Preferences of Functional Groups","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":320,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Chemoselectivity; Categorization; Set (abstract data type); Computer science; Key (lock); Management science; Data science; Risk analysis (engineering); Engineering; Business; Artificial intelligence; Chemistry; Computer security","authors":[{"name":"Nicholas A. Afagh","is_ca":true},{"name":"Andrei K. Yudin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009104687644575619,"gpt":0.2302611133610994,"spread":0.2211564257165238,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002298213,0.0008469518,0.0006297817,0.0005216042,0.0007691329,0.001265423,0.001142872,0.001101703,0.003316874],"category_scores_gemma":[0.002642481,0.0006447466,0.0005314208,0.0004117458,0.0026711,0.002906688,0.00168837,0.003398338,0.001998595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006054392,"about_ca_system_score_gemma":0.000640679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003849253,"about_ca_topic_score_gemma":0.0006267668,"domain_scores_codex":[0.9984107,0.000354665,0.00009277127,0.0004104968,0.000527297,0.0002041864],"domain_scores_gemma":[0.9985227,0.0008537802,0.000191026,0.0002129708,0.0001703966,0.00004909257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001715286,0.00006321363,0.00106519,0.002384023,0.00008491443,0.0007407792,0.0006208282,0.0019768,0.8254825,0.08774171,0.002280183,0.07738826],"study_design_scores_gemma":[0.00002551844,0.0004888783,0.001633881,0.0001782211,0.00005457081,0.002547606,0.0003196324,0.00141509,0.8686974,0.0417133,0.08282255,0.0001033344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3624669,0.1025979,0.4055875,0.01244911,0.001758716,0.000429125,0.001062862,0.001459289,0.1121886],"genre_scores_gemma":[0.8791617,0.04179154,0.05678864,0.003693162,0.0005271647,0.0004291846,0.0006632109,0.0003952827,0.01655011],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003316874,"threshold_uncertainty_score":0.01215422,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2010560388","doi":"10.1038/nprot.2007.160","title":"Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion","year":2007,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":279,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Peptide; Cellulose; Combinatorial chemistry; Cleavage (geology); Amino acid; Chemistry; Membrane; Peptide synthesis; Biochemistry; Materials science","authors":[{"name":"Kai Hilpert","is_ca":true},{"name":"Dirk Winkler","is_ca":true},{"name":"Robert E. W. Hancock","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00903648897586372,"gpt":0.315293399113369,"spread":0.3062569101375053,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004153158,0.0007664505,0.0008052131,0.0004739763,0.000329913,0.0005606747,0.0008554342,0.0005618439,0.002023212],"category_scores_gemma":[0.0003494281,0.0004768319,0.0003581223,0.0007381918,0.0003470896,0.0006320507,0.0003859733,0.001061685,0.001832805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003057664,"about_ca_system_score_gemma":0.000648335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005329359,"about_ca_topic_score_gemma":0.001287402,"domain_scores_codex":[0.9995329,0.00004243151,0.00002198068,0.00008678412,0.0002640983,0.00005194496],"domain_scores_gemma":[0.9998056,0.00004714552,0.00003779884,0.00002397474,0.00003535902,0.00005013692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009272713,0.00001495422,0.00003822038,0.0001070714,0.00000731526,0.00004692084,0.00001342379,0.00009901827,0.9878825,0.0002645806,0.0006706225,0.0107627],"study_design_scores_gemma":[0.0000172137,0.00008656166,0.0002147988,0.000003938029,0.000009561899,0.0001415587,0.00000608742,0.001799539,0.9934809,0.0001319697,0.004096198,0.00001171442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3233119,0.007449109,0.6460506,0.0008462806,0.000641288,0.0005133465,0.003665898,0.006245279,0.01127632],"genre_scores_gemma":[0.3444096,0.005953843,0.6314676,0.0003027233,0.0001956582,0.0006090139,0.003943066,0.0008650898,0.01225336],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002023212,"threshold_uncertainty_score":0.006768346,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2945082191","doi":"10.1039/c9cs00191c","title":"Boronic acid catalysis","year":2019,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Boronic acid; Catalysis; Chemistry; Combinatorial chemistry; Organic chemistry","authors":[{"name":"Dennis G. Hall","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04962192052706472,"gpt":0.3311512392611055,"spread":0.2815293187340407,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004287192,0.00133774,0.0008645057,0.001588274,0.0003592644,0.0008860429,0.001000243,0.001117515,0.003712424],"category_scores_gemma":[0.0002539549,0.0004556489,0.0004156402,0.001388576,0.0005498152,0.0009266926,0.0009406108,0.001757579,0.004441385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001332783,"about_ca_system_score_gemma":0.0008968594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320424,"about_ca_topic_score_gemma":0.001777181,"domain_scores_codex":[0.9996917,0.00003923295,0.00002133828,0.0000618876,0.0001192942,0.00006655095],"domain_scores_gemma":[0.9999477,0.00001202146,0.000009496733,0.000005011872,0.00001498861,0.0000107561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001157832,0.0001219134,0.0001365368,0.01920002,0.0001340686,0.0005682346,0.0001384301,0.001385013,0.04143774,0.06282847,0.06779075,0.8061431],"study_design_scores_gemma":[0.00001909927,0.00004031384,0.0001333868,0.0005332166,0.00001730845,0.0005663125,0.00001636317,0.0001191899,0.00936293,0.003555617,0.9856216,0.0000146436],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009221147,0.9710926,0.002730681,0.0004140853,0.0009137223,0.00003933725,0.00008069987,0.00008345536,0.02372324],"genre_scores_gemma":[0.01198186,0.972547,0.002056018,0.0005208469,0.0003070382,0.00006664046,0.0001722443,0.00001165165,0.0123367],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003712424,"threshold_uncertainty_score":0.01241928,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2512582262","doi":"10.1038/nature19804","title":"Diversity-oriented synthesis yields novel multistage antimalarial inhibitors","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; National Institutes of Health; Global Health Innovative Technology Fund; Medicines for Malaria Venture; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Bicyclic molecule; Malaria; Drug discovery; Antimalarial Agent; Drug development; Biology; Natural product; Computational biology; Drug; Pharmacology; Chemistry; Stereochemistry; Plasmodium falciparum; Bioinformatics; Biochemistry; Immunology","authors":[{"name":"Nobutaka Kato","is_ca":false},{"name":"Eamon Comer","is_ca":false},{"name":"Tomoyo Sakata‐Kato","is_ca":false},{"name":"Arvind Sharma","is_ca":false},{"name":"Manmohan Sharma","is_ca":false},{"name":"Micah Maetani","is_ca":false},{"name":"Jessica Bastien","is_ca":false},{"name":"Nicolas M. B. Brancucci","is_ca":false},{"name":"Joshua A. Bittker","is_ca":false},{"name":"Victoria Corey","is_ca":false},{"name":"David C. Clarke","is_ca":false},{"name":"Emily R. Derbyshire","is_ca":false},{"name":"Gillian L. Dornan","is_ca":true},{"name":"Sandra Duffy","is_ca":false},{"name":"Sean Eckley","is_ca":false},{"name":"Maurice A. Itoe","is_ca":false},{"name":"Karin M. J. Koolen","is_ca":false},{"name":"Timothy A. Lewis","is_ca":false},{"name":"Ping S. Lui","is_ca":false},{"name":"Amanda K. Lukens","is_ca":false},{"name":"Emily Lund","is_ca":false},{"name":"Sandra March","is_ca":false},{"name":"Elamaran Meibalan","is_ca":false},{"name":"Bennett C. Meier","is_ca":false},{"name":"Jacob A. McPhail","is_ca":true},{"name":"Branko Mitasev","is_ca":false},{"name":"Eli L. Moss","is_ca":false},{"name":"Morgane Sayes","is_ca":false},{"name":"Yvonne Van Gessel","is_ca":false},{"name":"Mathias J. Wawer","is_ca":false},{"name":"Takashi Yoshinaga","is_ca":false},{"name":"Anne‐Marie Zeeman","is_ca":false},{"name":"Vicky M. Avery","is_ca":false},{"name":"Sangeeta N. Bhatia","is_ca":false},{"name":"John E. Burke","is_ca":true},{"name":"Flaminia Catteruccia","is_ca":false},{"name":"Jon Clardy","is_ca":false},{"name":"Paul A. Clemons","is_ca":false},{"name":"Koen J. Dechering","is_ca":false},{"name":"Jeremy R. Duvall","is_ca":false},{"name":"Michael A. Foley","is_ca":false},{"name":"Fabian Gusovsky","is_ca":false},{"name":"Clemens H. M. Kocken","is_ca":false},{"name":"Matthias Marti","is_ca":false},{"name":"Marshall Morningstar","is_ca":false},{"name":"Benito Muñoz","is_ca":false},{"name":"Daniel E. Neafsey","is_ca":false},{"name":"Amit Sharma","is_ca":false},{"name":"Elizabeth A. Winzeler","is_ca":false},{"name":"Dyann F. Wirth","is_ca":false},{"name":"Christina Scherer","is_ca":false},{"name":"Stuart L. Schreiber","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005079806518027162,"gpt":0.2171431341325371,"spread":0.2120633276145099,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002525139,0.0004942137,0.0002780702,0.0002384378,0.0002397831,0.0004515886,0.0003681013,0.0003653367,0.001408359],"category_scores_gemma":[0.0001948245,0.0002575586,0.0002008787,0.0002209729,0.0002178614,0.0004608257,0.0003962034,0.0008865369,0.000687208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005958519,"about_ca_system_score_gemma":0.0003782351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003456128,"about_ca_topic_score_gemma":0.001232194,"domain_scores_codex":[0.9998745,0.00001552189,0.000007899325,0.0000277328,0.00003710584,0.00003728967],"domain_scores_gemma":[0.9999242,0.00001621473,0.00001886711,0.00001159118,0.00001490712,0.00001430416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403561,0.00008779192,0.0002558301,0.0001483388,0.00002889151,0.0002603244,0.00007499916,0.002669392,0.9645305,0.006983528,0.0009976599,0.02382229],"study_design_scores_gemma":[0.00002932421,0.0003929502,0.0002900214,0.000009592577,0.00002354957,0.0002056964,0.00001201317,0.002701279,0.979117,0.0008791746,0.01632518,0.00001424243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8060256,0.007565059,0.1282106,0.001203903,0.0003431857,0.0003825307,0.001441813,0.0009249949,0.05390215],"genre_scores_gemma":[0.9542253,0.004374777,0.03049246,0.0002467673,0.0000472173,0.0001135942,0.0005327174,0.00009190916,0.009875162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408359,"threshold_uncertainty_score":0.004711449,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2053698356","doi":"10.1021/ja910544p","title":"Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Epimer; Electrophile; Nucleophile; Cyclic peptide; Amino acid; Molecule; Combinatorial chemistry; Nucleophilic addition; Peptide; Stereochemistry; Organic chemistry; Biochemistry; Catalysis","authors":[{"name":"Ryan Hili","is_ca":true},{"name":"Vishal Rai","is_ca":true},{"name":"Andrei K. Yudin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003283214105772792,"gpt":0.2261485392445161,"spread":0.2228653251387434,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600289,0.0003368502,0.0001568453,0.0002132953,0.000147375,0.000223878,0.0001404403,0.0001390121,0.001626535],"category_scores_gemma":[0.0002198031,0.0001013102,0.000129448,0.0001074495,0.0002013909,0.0002331054,0.0002866247,0.0003270339,0.0003613363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001790793,"about_ca_system_score_gemma":0.00016496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001842348,"about_ca_topic_score_gemma":0.0004217417,"domain_scores_codex":[0.9998707,0.00002074826,0.00001282654,0.00003667124,0.00002058989,0.00003840834],"domain_scores_gemma":[0.9998624,0.00003326506,0.00004279497,0.0000148825,0.00001447943,0.00003213477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001094457,0.00001840779,0.0001188947,0.00004838008,0.000004552503,0.000128737,0.00005256985,0.0002111044,0.9952981,0.0004330311,0.00005510655,0.003521796],"study_design_scores_gemma":[0.00001104184,0.0003129979,0.0005988809,0.000004080258,0.000005007649,0.0001175505,0.00001761239,0.0002545837,0.9954889,0.00005266992,0.003130275,0.000006318819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892993,0.001374048,0.004285839,0.00006367701,0.00005289875,0.00008465443,0.0001914877,0.0001214107,0.004526643],"genre_scores_gemma":[0.9933982,0.0008218671,0.00378382,0.00005001611,0.00001932752,0.00004466566,0.0001466097,0.00004234857,0.001693195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626535,"threshold_uncertainty_score":0.005441248,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2152596956","doi":"10.1002/anie.200605219","title":"Chemistry and Biology of the Aeruginosin Family of Serine Protease Inhibitors","year":2007,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Proteases; Serine; Chemistry; Serine protease; Amino acid; Biochemistry; Stereochemistry; Peptide; Protease; Structural biology; Structural chemistry; Chemical biology; Enzyme","authors":[{"name":"Karolina Ersmark","is_ca":true},{"name":"Juan R. Del Valle","is_ca":false},{"name":"Stephen Hanessian","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009290873400495673,"gpt":0.2508436628707951,"spread":0.2415527894702995,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113062,0.0003254029,0.0001584486,0.000200332,0.0001599354,0.0003465379,0.0001891499,0.0002129533,0.0006042062],"category_scores_gemma":[0.00008733394,0.0001155134,0.0001061656,0.0001675891,0.0001908321,0.0003841216,0.0001493221,0.0003658201,0.0003728228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004431606,"about_ca_system_score_gemma":0.0002406151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006719691,"about_ca_topic_score_gemma":0.0005274045,"domain_scores_codex":[0.9999473,0.00001053745,0.000002895692,0.000009267966,0.00001921023,0.00001078155],"domain_scores_gemma":[0.9999753,0.000002890807,0.000005504118,0.000002081799,0.000006963792,0.000007355617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137699,0.00003207395,0.000284641,0.0003441057,0.00001994586,0.0003741856,0.00007003209,0.001700351,0.9347731,0.0110284,0.0009852736,0.05027404],"study_design_scores_gemma":[0.00002852333,0.0002734483,0.001502261,0.00002745527,0.00001685642,0.001283728,0.00003324924,0.001768443,0.8347803,0.002752225,0.1575135,0.00001998736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5295979,0.3411838,0.0638331,0.003719909,0.0005345179,0.0001530957,0.0006209718,0.0005700162,0.05978667],"genre_scores_gemma":[0.8726637,0.09581392,0.01013244,0.0003794387,0.000211053,0.00008280797,0.0003455472,0.00003109124,0.02033994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006719691,"threshold_uncertainty_score":0.003215373,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2148129267","doi":"10.1021/jo3013258","title":"Direct Amidation of Carboxylic Acids Catalyzed by <i>ortho</i>-Iodo Arylboronic Acids: Catalyst Optimization, Scope, and Preliminary Mechanistic Study Supporting a Peculiar Halogen Acceleration Effect","year":2012,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Catalysis; Substituent; Amide; Organic chemistry; Carboxylic acid; Reagent; Combinatorial chemistry","authors":[{"name":"Nicolas Gernigon","is_ca":true},{"name":"Raed M. Al‐Zoubi","is_ca":true},{"name":"Dennis G. Hall","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004437684018486629,"gpt":0.225351645741257,"spread":0.2209139617227704,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957163,0.0005806822,0.0002535801,0.0001844098,0.00008959779,0.0001544796,0.0003081415,0.000301178,0.0006578495],"category_scores_gemma":[0.000199593,0.0001578635,0.0002350386,0.0001618306,0.0001250405,0.000218693,0.0002320063,0.0003373575,0.0003198845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001470133,"about_ca_system_score_gemma":0.0002154912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003304878,"about_ca_topic_score_gemma":0.0009261448,"domain_scores_codex":[0.9998752,0.00001963841,0.00001252071,0.00002503903,0.0000223896,0.00004513982],"domain_scores_gemma":[0.9999288,0.00001265294,0.00002139751,0.000007179472,0.0000122625,0.00001760641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001204726,0.00003502683,0.0001587129,0.0001237927,0.0000112853,0.00009005982,0.00002404459,0.0002028864,0.9955206,0.0001728168,0.00003532974,0.00350491],"study_design_scores_gemma":[0.000009629855,0.0003320267,0.0005361394,0.00000506032,0.0000143679,0.0001072393,0.000008403355,0.0005375174,0.9972759,0.00003133202,0.001136974,0.000005419656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839478,0.003858572,0.008590902,0.00007988063,0.00002950995,0.00005614127,0.0001716069,0.00007399645,0.003191619],"genre_scores_gemma":[0.9904269,0.00283971,0.005279247,0.00002669557,0.00001280636,0.00002600502,0.000210434,0.00001694579,0.001161304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006578495,"threshold_uncertainty_score":0.002200723,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2128994224","doi":"10.1073/pnas.0809052106","title":"Site-specific C-functionalization of free-(NH) peptides and glycine derivatives via direct C–H bond functionalization","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":222,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Surface modification; Combinatorial chemistry; Chemistry; Glycine; Peptide; Stereocenter; Nucleophile; Stereochemistry; Amino acid; Organic chemistry; Enantioselective synthesis; Catalysis; Biochemistry","authors":[{"name":"Liang Zhao","is_ca":true},{"name":"Oliver Baslé","is_ca":true},{"name":"Chao‐Jun Li","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0183043888070617,"gpt":0.2543003297303325,"spread":0.2359959409232708,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176903,0.0004401516,0.0001801418,0.0001291196,0.0001252894,0.0001279801,0.000264445,0.0002136998,0.001021271],"category_scores_gemma":[0.0001212105,0.0001315083,0.000168269,0.0001012629,0.0001759246,0.0001853374,0.0001742233,0.0002973075,0.0002646897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686515,"about_ca_system_score_gemma":0.0001523343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003376593,"about_ca_topic_score_gemma":0.0004979406,"domain_scores_codex":[0.9999216,0.00001386677,0.000005957388,0.0000172051,0.00002066426,0.00002082377],"domain_scores_gemma":[0.9999483,0.000009042203,0.00001455617,0.00000766742,0.000006386445,0.00001400604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003179966,0.000009595758,0.00003717221,0.00004147948,0.000003144424,0.0001085498,0.00001023702,0.00008280051,0.9973431,0.0001579157,0.00004554544,0.002128731],"study_design_scores_gemma":[0.000007221749,0.00009547253,0.0003179087,0.000001498861,0.000003565736,0.0002946187,0.000003998888,0.0001971692,0.9976528,0.00002809297,0.001393934,0.000003739726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759679,0.001972262,0.01629023,0.00009168114,0.00006290765,0.00008410286,0.0002266355,0.0001531664,0.005151179],"genre_scores_gemma":[0.9879915,0.0009049512,0.008562581,0.00004659989,0.00001667329,0.00002748235,0.0001604558,0.00002629988,0.002263301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021271,"threshold_uncertainty_score":0.003416479,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2299985318","doi":"10.1021/acscombsci.5b00198","title":"What is a “DNA-Compatible” Reaction?","year":2016,"lang":"en","type":"article","venue":"ACS Combinatorial Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"NIH Office of the Director; Natural Sciences and Engineering Research Council of Canada; Defense Advanced Research Projects Agency; National Institutes of Health","keywords":"Chemistry; DNA; Combinatorial chemistry; Computational biology; Biochemistry","authors":[{"name":"Marie L. Malone","is_ca":false},{"name":"Brian M. Paegel","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007891952906983392,"gpt":0.253829741847994,"spread":0.2459377889410106,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004062388,0.001123695,0.001315747,0.0008694432,0.0007717877,0.003419446,0.0009791907,0.002300615,0.003052552],"category_scores_gemma":[0.008818808,0.0006414079,0.0007507671,0.0009306028,0.003167272,0.005777324,0.0009131774,0.001963048,0.002567868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001367173,"about_ca_system_score_gemma":0.002059734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000435549,"about_ca_topic_score_gemma":0.0006503087,"domain_scores_codex":[0.9970747,0.0007615159,0.0002749679,0.000656612,0.0009819061,0.0002503198],"domain_scores_gemma":[0.9966171,0.001226897,0.0008079048,0.0003900832,0.00051947,0.0004385842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008791257,0.0007457473,0.006556718,0.007086109,0.0003158253,0.002219526,0.0007947407,0.006998599,0.4499389,0.2974544,0.005993071,0.2210173],"study_design_scores_gemma":[0.0001173322,0.001638928,0.0017061,0.0008839651,0.0002628107,0.003413677,0.001080508,0.008853678,0.6344702,0.1469794,0.200353,0.0002404666],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2706142,0.07891078,0.5453446,0.03487444,0.004037523,0.00110137,0.00149794,0.001885588,0.06173357],"genre_scores_gemma":[0.6931947,0.03104233,0.255823,0.006779726,0.000768166,0.0005969238,0.0008276345,0.0006152522,0.01035223],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004062388,"threshold_uncertainty_score":0.0214842,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2142218380","doi":"10.1002/1521-3773(20010119)40:2<339::aid-anie339>3.0.co;2-j","title":"Diversity-Based Organic Synthesis in the Era of Genomics and Proteomics","year":2001,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Steacie Institute for Molecular Sciences","funders":"","keywords":"Genomics; Proteomics; Identification (biology); Computational biology; Genome; Biology; Diversity (politics); Gene; Gene sequence; Data science; Sequence (biology); Genetics; Computer science; Political science","authors":[{"name":"Prabhat Arya","is_ca":true},{"name":"Doug T. H. Chou","is_ca":true},{"name":"Myung‐Gi Baek","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009287641059183747,"gpt":0.2199027320850403,"spread":0.2106150910258565,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001854048,0.000294046,0.0006985621,0.0005621965,0.0008936415,0.00153123,0.0006652495,0.001264365,0.002283303],"category_scores_gemma":[0.001414629,0.0003252925,0.0002589231,0.0006823702,0.00303008,0.00496034,0.001707589,0.00224721,0.0009797786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001850132,"about_ca_system_score_gemma":0.0009191083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004805807,"about_ca_topic_score_gemma":0.000847684,"domain_scores_codex":[0.9994249,0.0001774268,0.00002224322,0.00007471595,0.0001932626,0.0001074353],"domain_scores_gemma":[0.9993415,0.0003690681,0.00006407323,0.00006190494,0.00006672481,0.0000966786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003116076,0.00008495463,0.0008701769,0.00193636,0.00007746894,0.0006581834,0.00080796,0.004565381,0.0977747,0.5366287,0.01798847,0.3382961],"study_design_scores_gemma":[0.00005456626,0.0002607917,0.0004874206,0.000246083,0.00002843415,0.0006028255,0.00037781,0.002212886,0.03750129,0.6369146,0.3212256,0.00008768713],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07717329,0.6757913,0.1122132,0.06913967,0.004628655,0.00008288799,0.0003451769,0.0006558753,0.05996997],"genre_scores_gemma":[0.6169368,0.3008351,0.05182531,0.009589893,0.002177438,0.0001538495,0.0002114651,0.0001221648,0.01814794],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002283303,"threshold_uncertainty_score":0.01342368,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2226590694","doi":"10.1021/acs.accounts.5b00439","title":"Design, Synthesis, Assembly, and Engineering of Peptoid Nanosheets","year":2016,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; Defense Threat Reduction Agency","keywords":"Peptoid; Supramolecular chemistry; Nanomaterials; Polymer; Nanotechnology; Materials science; Surface modification; Monomer; Characterization (materials science); Ionic bonding; Chemistry; Molecule; Ion; Organic chemistry; Peptide","authors":[{"name":"Ellen J. Robertson","is_ca":false},{"name":"Alessia Battigelli","is_ca":false},{"name":"Caroline Proulx","is_ca":false},{"name":"Ranjan V. Mannige","is_ca":false},{"name":"Thomas K. Haxton","is_ca":false},{"name":"Lisa Yun","is_ca":false},{"name":"Stephen Whitelam","is_ca":false},{"name":"Ronald N. Zuckermann","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.029270799498632,"gpt":0.3075721851225219,"spread":0.2783013856238899,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930012,0.0002918694,0.0002162222,0.000262554,0.0002133098,0.0002977006,0.000327481,0.0002775476,0.0004943152],"category_scores_gemma":[0.0002136446,0.0003271143,0.0002237743,0.0002158525,0.0002010149,0.0003864489,0.0002484981,0.0003883353,0.0002983294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003837404,"about_ca_system_score_gemma":0.0002672501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002531609,"about_ca_topic_score_gemma":0.0005050944,"domain_scores_codex":[0.9998966,0.00001333438,0.00001305317,0.00002766141,0.00003262538,0.00001661503],"domain_scores_gemma":[0.9999375,0.00001320352,0.00001642296,0.000007234174,0.00001217319,0.00001343254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004915729,0.00003723735,0.0003554873,0.0001424925,0.00001360373,0.00009987658,0.00003637083,0.010395,0.9795827,0.002668986,0.00008516971,0.006534033],"study_design_scores_gemma":[0.00002238362,0.0001741415,0.0007041121,0.000008084614,0.000009403294,0.00007678292,0.00001877405,0.01626991,0.9771528,0.0003836046,0.005168792,0.00001105344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8969381,0.002042818,0.09358773,0.0001789634,0.00008581288,0.0005271913,0.0006178133,0.0002232422,0.005798281],"genre_scores_gemma":[0.8776312,0.001704668,0.1161057,0.00008178322,0.00001645245,0.0004612158,0.0004789402,0.00005636564,0.003463811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004943152,"threshold_uncertainty_score":0.002784193,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2023618081","doi":"10.3390/molecules15085282","title":"Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives","year":2010,"lang":"en","type":"review","venue":"Molecules","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Atlantic Cancer Research Institute; Mount Allison University","funders":"","keywords":"Peptoid; Chemistry; Solid-phase synthesis; Monomer; Combinatorial chemistry; Peptidomimetic; Side chain; Stereochemistry; Organic chemistry; Polymer; Peptide; Biochemistry","authors":[{"name":"Adrian S. Culf","is_ca":true},{"name":"Rodney J. Ouellette","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01666235731567782,"gpt":0.3521988555007882,"spread":0.3355364981851104,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577758,0.0006718174,0.0005718054,0.0006959563,0.000142315,0.0002953598,0.000381439,0.0004210177,0.001021498],"category_scores_gemma":[0.0001291657,0.0002925765,0.0003064875,0.0008485439,0.0001964174,0.0005942998,0.0003155885,0.0005491943,0.00163131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003411179,"about_ca_system_score_gemma":0.0003493157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003406176,"about_ca_topic_score_gemma":0.0005662636,"domain_scores_codex":[0.9999067,0.0000114101,0.000008551213,0.00002354435,0.00003589989,0.00001390381],"domain_scores_gemma":[0.9999654,0.000007333249,0.00001172986,0.000002803218,0.000008047949,0.000004624127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001033022,0.0001701743,0.0001872751,0.01821889,0.00006797726,0.0005788215,0.00009998005,0.001997196,0.32377,0.01239357,0.007634947,0.6347778],"study_design_scores_gemma":[0.00002644498,0.0004523916,0.0008010475,0.0008200184,0.00006950866,0.001959963,0.00004820173,0.0006139423,0.2472712,0.002339573,0.7455571,0.00004057003],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01080762,0.9686484,0.007386118,0.0002091249,0.0003381103,0.00007368623,0.0001627429,0.00007416699,0.01230003],"genre_scores_gemma":[0.03967884,0.9429991,0.007842452,0.0001703481,0.0001080845,0.00008632294,0.0002866992,0.00001678478,0.008811337],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001021498,"threshold_uncertainty_score":0.003417253,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2538778544","doi":"10.1038/nchem.2636","title":"Oxadiazole grafts in peptide macrocycles","year":2016,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Peptidomimetic; Peptide; Cyclic peptide; Intramolecular force; Oxadiazole; Aldehyde; Combinatorial chemistry; Amine gas treating; Hydrogen bond; Molecule; Stereochemistry; Organic chemistry","authors":[{"name":"John R. Frost","is_ca":true},{"name":"Conor C. G. Scully","is_ca":true},{"name":"Andrei K. Yudin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.002142834418314491,"gpt":0.2149833660773124,"spread":0.2128405316589979,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007594125,0.000155068,0.0001064913,0.0001314505,0.0001323982,0.0002488951,0.0001676284,0.0001454945,0.001658737],"category_scores_gemma":[0.00009949189,0.0001009844,0.00005650154,0.0001231095,0.0001702088,0.0002448357,0.000252789,0.0002947834,0.0003361723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229252,"about_ca_system_score_gemma":0.00009748115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003341368,"about_ca_topic_score_gemma":0.0007183761,"domain_scores_codex":[0.9999539,0.000005593513,0.00000277308,0.000008760585,0.000009695381,0.00001943459],"domain_scores_gemma":[0.9999633,0.00000819773,0.000008954617,0.00000503999,0.000002999819,0.00001159905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723595,0.00003753605,0.0002241832,0.00005673318,0.000004438083,0.0002426293,0.0000799414,0.00107065,0.9851829,0.005888793,0.0002271852,0.006812542],"study_design_scores_gemma":[0.00002815707,0.0006000397,0.001320957,0.000008883264,0.000008278739,0.0002063872,0.00003632547,0.001897837,0.9873384,0.0006178719,0.00792617,0.00001075285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921201,0.000729643,0.002137977,0.00005149515,0.00003240803,0.00001188226,0.00005091191,0.00006436495,0.004801203],"genre_scores_gemma":[0.9959266,0.0004311868,0.0007927261,0.00002375677,0.000006114704,0.000008695274,0.0000314498,0.00001255973,0.002766833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658737,"threshold_uncertainty_score":0.005549014,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2046032676","doi":"10.1021/ja035716j","title":"Catalytic Construction and Reconstruction of Guanidines:  Ti-Mediated Guanylation of Amines and Transamination of Guanidines","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"","keywords":"Chemistry; Transamination; Catalysis; Combinatorial chemistry; Organic chemistry; Biochemistry; Amino acid","authors":[{"name":"Tiow‐Gan Ong","is_ca":true},{"name":"Glenn P. A. Yap","is_ca":true},{"name":"D.S. Richeson","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005222155341618667,"gpt":0.2142472811668729,"spread":0.2090251258252542,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549123,0.0002754127,0.0002102867,0.0001120687,0.0001459486,0.0002416405,0.0005423191,0.0002433648,0.0005752252],"category_scores_gemma":[0.0002149017,0.0001873483,0.0001813731,0.0001135639,0.0002111784,0.0001412944,0.0002597938,0.0004523128,0.0002767916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003867014,"about_ca_system_score_gemma":0.0002171973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006752358,"about_ca_topic_score_gemma":0.001193548,"domain_scores_codex":[0.9998889,0.00001254558,0.000008022123,0.00002851974,0.00003185779,0.00003021576],"domain_scores_gemma":[0.9999394,0.000006104196,0.00001775163,0.00001252234,0.000008840298,0.00001535617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002773475,0.000007002057,0.00005676805,0.00003446402,0.000002749351,0.00004614224,0.00002449773,0.0001921025,0.9971964,0.0007855593,0.00003067335,0.001595859],"study_design_scores_gemma":[0.000007351343,0.0000471188,0.0002525326,0.00000148039,0.000003859239,0.00009507356,0.000006180812,0.0006865072,0.9970269,0.00004936732,0.00182005,0.000003710357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703566,0.0009890898,0.02278858,0.0000785847,0.00006184311,0.00007049785,0.0002247573,0.0003458141,0.005084219],"genre_scores_gemma":[0.9747183,0.0005294967,0.02097543,0.00001998891,0.00000698805,0.00004161904,0.0002511937,0.00005873368,0.003398299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006752358,"threshold_uncertainty_score":0.00280571,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2082198102","doi":"10.1021/cc0001001","title":"Solution- and Solid-Phase Strategies for the Design, Synthesis, and Screening of Libraries Based on Natural Product Templates:  A Comprehensive Survey","year":2001,"lang":"en","type":"review","venue":"Journal of Combinatorial Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"University of Alberta","funders":"","keywords":"Citation; Computer science; Social media; Reuse; Library science; Product (mathematics); World Wide Web; Information retrieval; Mathematics; Biology; Ecology","authors":[{"name":"Dennis G. Hall","is_ca":true},{"name":"Sukhdev Manku","is_ca":true},{"name":"Fan Wang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05506940910171357,"gpt":0.3436317443048407,"spread":0.2885623352031271,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006291246,0.001507774,0.002100917,0.009687291,0.0008687629,0.00245225,0.001319484,0.001144491,0.00342994],"category_scores_gemma":[0.006844241,0.0008218258,0.001630377,0.008195651,0.0007519066,0.0033168,0.00136063,0.001101243,0.001868061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009077885,"about_ca_system_score_gemma":0.002550688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001900359,"about_ca_topic_score_gemma":0.003890296,"domain_scores_codex":[0.9961053,0.0007123015,0.0004595071,0.0004639043,0.001999284,0.0002596926],"domain_scores_gemma":[0.9922507,0.004131459,0.0009877983,0.0006554736,0.001584954,0.0003895527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002210278,0.0006661946,0.003965006,0.00759619,0.0003769089,0.0001940811,0.0004660204,0.002824018,0.03336874,0.001546583,0.007285053,0.9414902],"study_design_scores_gemma":[0.0001917725,0.009435656,0.02854283,0.0052902,0.002066913,0.003168088,0.001931246,0.006677995,0.2053075,0.004881873,0.7321666,0.0003393349],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1090279,0.8087925,0.04346158,0.001845322,0.000147425,0.00116835,0.003885094,0.001225851,0.03044612],"genre_scores_gemma":[0.1439009,0.7707278,0.06175091,0.001865073,0.0001535647,0.0006595077,0.01275539,0.0003067241,0.007880138],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009687291,"threshold_uncertainty_score":0.03327167,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2095361639","doi":"10.4155/fmc.11.74","title":"Azapeptides and Their Therapeutic Potential","year":2011,"lang":"en","type":"review","venue":"Future Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Peptide; Chemistry; Amino acid residue; Amino acid; Combinatorial chemistry; Residue (chemistry); Stereochemistry; Biochemistry; Peptide sequence","authors":[{"name":"Caroline Proulx","is_ca":true},{"name":"David A. Sabatino","is_ca":true},{"name":"Robert Hopewell","is_ca":true},{"name":"Jochen Spiegel","is_ca":true},{"name":"Yésica García Ramos","is_ca":true},{"name":"William D. Lubell","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01350880059864491,"gpt":0.253939293217148,"spread":0.2404304926185031,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003351002,0.0005028306,0.0006221608,0.001058186,0.0002005434,0.0006589445,0.0004523704,0.0007922404,0.002665089],"category_scores_gemma":[0.0003248667,0.0001789757,0.0002022781,0.0008476324,0.0003964495,0.0008812395,0.0003878374,0.001477031,0.001757575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005030003,"about_ca_system_score_gemma":0.0003845633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004231992,"about_ca_topic_score_gemma":0.0008125458,"domain_scores_codex":[0.9998732,0.00002264039,0.00001341053,0.00002205085,0.00005495901,0.00001374801],"domain_scores_gemma":[0.9999197,0.00003532978,0.00001181769,0.00000307078,0.00002115625,0.000009035893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001137727,0.00007443875,0.0001381837,0.005939013,0.00003653402,0.0003901046,0.00006779593,0.0006074508,0.01050975,0.0156801,0.01491845,0.9515244],"study_design_scores_gemma":[0.00001660637,0.00009762851,0.0003870084,0.0007299455,0.00002326263,0.00183195,0.00003078038,0.0001213915,0.002497616,0.003228843,0.9910233,0.00001157936],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003783105,0.9965592,0.0002551549,0.0002082996,0.0001128768,0.000004003288,0.00001571306,0.000006783118,0.00245969],"genre_scores_gemma":[0.00320293,0.99393,0.0004451257,0.0002230506,0.0001671656,0.00001089671,0.00003588173,0.000001608242,0.001983335],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002665089,"threshold_uncertainty_score":0.008915663,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2109914800","doi":"10.1002/anie.201310937","title":"An Efficient and Modular Route to Sequence‐Defined Polymers Appended to DNA","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Polymer; Dispersity; DNA; Sequence (biology); Biopolymer; Combinatorial chemistry; Solid-phase synthesis; Modular design; Materials science; DNA sequencing; Nanotechnology; Chemistry; Computer science; Peptide; Organic chemistry; Polymer chemistry; Biochemistry","authors":[{"name":"Thomas G. W. Edwardson","is_ca":true},{"name":"Karina M. M. Carneiro","is_ca":true},{"name":"Christopher J. Serpell","is_ca":true},{"name":"Hanadi F. Sleiman","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009382676711308968,"gpt":0.2575609341907036,"spread":0.2481782574793946,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754736,0.0007734829,0.0003037305,0.0004443755,0.000220027,0.0003213131,0.0007911228,0.0005538249,0.001452611],"category_scores_gemma":[0.0002152967,0.0004745366,0.0004159937,0.0003559162,0.0002916819,0.0005123458,0.0006809472,0.001332872,0.001298108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003802102,"about_ca_system_score_gemma":0.0006122657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002855438,"about_ca_topic_score_gemma":0.00046553,"domain_scores_codex":[0.9998054,0.00002066468,0.00002066003,0.00006044875,0.0000495491,0.0000433431],"domain_scores_gemma":[0.9998854,0.00001912975,0.00004414943,0.00001638028,0.00001100358,0.00002393092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004096169,0.00006934837,0.0000389064,0.0001280602,0.000009326403,0.0001713118,0.00003760713,0.0007516662,0.9859007,0.002293283,0.0002764323,0.01028244],"study_design_scores_gemma":[0.00002336162,0.0003074835,0.0001993799,0.0000068078,0.000008806747,0.0002152396,0.000003380441,0.0009660143,0.990202,0.0002152047,0.00783588,0.00001640178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7044418,0.005414437,0.2620799,0.0009353149,0.0006348161,0.0009520625,0.001248711,0.003023798,0.02126929],"genre_scores_gemma":[0.8567559,0.003135845,0.1249714,0.000335121,0.00009673444,0.0005404621,0.0008869578,0.0002318404,0.01304587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452611,"threshold_uncertainty_score":0.004859507,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2129695455","doi":"10.1002/cphc.201001050","title":"Molecular Tweezers: Concepts and Applications","year":2011,"lang":"en","type":"review","venue":"ChemPhysChem","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Molecular tweezers; Nanotechnology; Tweezers; Optical tweezers; Materials science; Chemistry; Supramolecular chemistry; Physics; Molecule; Optics; Physical chemistry; Organic chemistry","authors":[{"name":"Jeanne Leblond Chain","is_ca":true},{"name":"Anne Petitjean","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02295394457747746,"gpt":0.3057970491221537,"spread":0.2828431045446763,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006816396,0.001218848,0.001089789,0.002139521,0.0005589254,0.001405938,0.001374498,0.002108459,0.005147209],"category_scores_gemma":[0.0006661459,0.0005113485,0.0004387468,0.001962868,0.001663176,0.002926224,0.001268349,0.003022011,0.004542472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001197823,"about_ca_system_score_gemma":0.0007776594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006872981,"about_ca_topic_score_gemma":0.000666736,"domain_scores_codex":[0.9995671,0.0000567162,0.00003386569,0.00008891875,0.0002085294,0.00004492863],"domain_scores_gemma":[0.9997796,0.00009808048,0.00002648944,0.00001652039,0.00005497809,0.00002442115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005835145,0.0001086765,0.00009934211,0.008286994,0.00004120815,0.0002721749,0.0001759947,0.00122622,0.01443008,0.05485046,0.03541258,0.885038],"study_design_scores_gemma":[0.000006492483,0.00003512703,0.000090563,0.0006026994,0.000008055358,0.0004120538,0.00002486508,0.0001696901,0.002032348,0.006133009,0.9904696,0.0000154577],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002427264,0.9912065,0.001757038,0.0004968778,0.0004160065,0.00001233679,0.00001812231,0.0000438369,0.005806609],"genre_scores_gemma":[0.00331267,0.9865841,0.002381026,0.0005152709,0.0004610329,0.00004145745,0.00003442332,0.00001121692,0.006658839],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005147209,"threshold_uncertainty_score":0.01721919,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2121151545","doi":"10.1002/anie.200704711","title":"Enamide Synthesis by Copper‐Catalyzed Cross‐Coupling of Amides and Potassium Alkenyltrifluoroborate Salts","year":2008,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Halide; Potassium; Chemistry; Catalysis; Copper; Coupling (piping); Combinatorial chemistry; Organic chemistry; Medicinal chemistry; Materials science","authors":[{"name":"Yuri Bolshan","is_ca":true},{"name":"Robert A. Batey","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01007685092688852,"gpt":0.2449072534674652,"spread":0.2348304025405767,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598656,0.0007391559,0.0003100176,0.0002642847,0.0002480177,0.0003344045,0.0003902886,0.000341633,0.002006325],"category_scores_gemma":[0.0001804976,0.0002778449,0.0002501951,0.0002025209,0.000231652,0.0004889931,0.000404831,0.0004754723,0.001060678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003084521,"about_ca_system_score_gemma":0.0003334844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005445495,"about_ca_topic_score_gemma":0.0009686231,"domain_scores_codex":[0.9998382,0.00001604806,0.0000248371,0.00004459577,0.00003667666,0.00003960231],"domain_scores_gemma":[0.9999274,0.000005480066,0.00001783344,0.0000151412,0.00001634255,0.00001777815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006276672,0.00003773612,0.00006801966,0.0001465019,0.00001428448,0.0002415113,0.00004090654,0.0001931521,0.9907617,0.0007261421,0.0001675656,0.007539707],"study_design_scores_gemma":[0.00001520311,0.0001186952,0.0001742511,0.000005066749,0.000008662811,0.0002122229,0.00000559954,0.0001306086,0.9940335,0.00004912016,0.005240966,0.000006176094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8860837,0.006215228,0.06442287,0.0002751079,0.0004084862,0.0004712237,0.000998662,0.001156275,0.03996835],"genre_scores_gemma":[0.9513314,0.004625208,0.02993645,0.00006085007,0.00004005637,0.0001582658,0.000667598,0.000129823,0.01305043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006325,"threshold_uncertainty_score":0.006711841,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2575712535","doi":"10.1039/c6ra25879d","title":"In situ Raman spectroscopy distinguishes between reversible and irreversible thiol modifications in<scp>l</scp>-cysteine","year":2017,"lang":"en","type":"article","venue":"RSC Advances","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Raman spectroscopy; In situ; Cysteine; Thiol; Chemistry; Spectroscopy; Breakage; Materials science; Biochemistry; Organic chemistry; Physics; Optics","authors":[{"name":"Paul Bazylewski","is_ca":true},{"name":"Ranjith Divigalpitiya","is_ca":false},{"name":"Giovanni Fanchini","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01393188921368597,"gpt":0.2816933932291562,"spread":0.2677615040154702,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000246366,0.0004360832,0.0001377381,0.0002186491,0.0002784448,0.0002383719,0.0004728551,0.0004567243,0.003413721],"category_scores_gemma":[0.0004169062,0.0002219063,0.0001928441,0.0001750155,0.0004217192,0.0002620696,0.0002572305,0.0007359091,0.0004036816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247846,"about_ca_system_score_gemma":0.0001969744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159968,"about_ca_topic_score_gemma":0.00245437,"domain_scores_codex":[0.9998226,0.00002003424,0.00001037188,0.00005145585,0.00005484304,0.00004082976],"domain_scores_gemma":[0.9997453,0.00006964916,0.00006911039,0.00003619891,0.00005396539,0.00002568581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002498831,0.000005959103,0.00009009162,0.00001875771,0.000003494671,0.0000207543,0.00002199132,0.00001845132,0.9991303,0.00005005314,0.00004230938,0.0005729661],"study_design_scores_gemma":[0.000001586744,0.00003396183,0.0009909888,0.000001681764,0.000003705511,0.00003461915,0.00002163836,0.000212604,0.9983405,0.0000219536,0.0003334905,0.000003309482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907112,0.0003424774,0.005848823,0.0001390493,0.00003976793,0.0000154015,0.0002640757,0.0001019545,0.00253732],"genre_scores_gemma":[0.9902908,0.0004330678,0.004833433,0.00007102481,0.00000925535,0.00002741145,0.0004132163,0.0000528485,0.003868937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003413721,"threshold_uncertainty_score":0.01142001,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1995938340","doi":"10.1016/j.chembiol.2005.01.011","title":"Exploring New Chemical Space by Stereocontrolled Diversity-Oriented Synthesis","year":2005,"lang":"en","type":"review","venue":"Chemistry & Biology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Steacie Institute for Molecular Sciences; University of Ottawa","funders":"National Cancer Institute","keywords":"Chemical space; Small molecule; Biology; Chemical biology; Computational biology; Natural product; Protein–protein interaction; Drug discovery; Biochemistry","authors":[{"name":"Prabhat Arya","is_ca":true},{"name":"Reni Joseph","is_ca":true},{"name":"Zhonghong Gan","is_ca":true},{"name":"Bojana Rakić","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05998328137411948,"gpt":0.2844250682445689,"spread":0.2244417868704494,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006896632,0.001210205,0.001703944,0.00102222,0.0003995346,0.001179491,0.002076885,0.0007625605,0.002019904],"category_scores_gemma":[0.0003190496,0.0005658487,0.0004560183,0.001512235,0.001346341,0.002029603,0.001141179,0.001989334,0.00203636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000898104,"about_ca_system_score_gemma":0.0006368485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005486738,"about_ca_topic_score_gemma":0.0009388399,"domain_scores_codex":[0.9997589,0.0000313596,0.0000172331,0.00004700123,0.00009689725,0.0000485743],"domain_scores_gemma":[0.9999052,0.00003449284,0.00001583671,0.00001191654,0.00002204582,0.00001046302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001352385,0.000140637,0.0001756664,0.007681152,0.0001097866,0.000553588,0.0001589622,0.004874254,0.07193357,0.08192088,0.01917347,0.8131427],"study_design_scores_gemma":[0.00009083652,0.0002565606,0.0002762705,0.0004201993,0.00007180458,0.001341339,0.00005533193,0.002333062,0.06867977,0.02593694,0.9004631,0.00007475074],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006913437,0.9137046,0.0498371,0.0008241904,0.001547133,0.000112116,0.0001657202,0.0004097645,0.02648589],"genre_scores_gemma":[0.04325273,0.9176672,0.02786674,0.0007629411,0.0005379423,0.0001617004,0.0003061876,0.00005663723,0.009387925],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002076885,"threshold_uncertainty_score":0.006757259,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2009915902","doi":"10.1110/ps.073287008","title":"Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5","year":2007,"lang":"en","type":"article","venue":"Protein Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Women's Health Research Institute","funders":"Argonne National Laboratory","keywords":"Aggrecanase; Aggrecan; Chemistry; Active site; Gene isoform; Enzyme; Crystal structure; Biochemistry; Stereochemistry; Crystallography; Osteoarthritis; Articular cartilage; Gene","authors":[{"name":"Lidia Mosyak","is_ca":true},{"name":"Katy E. Georgiadis","is_ca":false},{"name":"Tania Shane","is_ca":false},{"name":"Kristine Svenson","is_ca":false},{"name":"Tracy Hebert","is_ca":false},{"name":"Thomas McDonagh","is_ca":false},{"name":"Stewart A. Mackie","is_ca":false},{"name":"Stéphane Olland","is_ca":false},{"name":"Laura Lin","is_ca":false},{"name":"Xiaotian Zhong","is_ca":false},{"name":"Ronald Kriz","is_ca":false},{"name":"Erica Reifenberg","is_ca":false},{"name":"Lisa A. Collins‐Racie","is_ca":false},{"name":"Christopher Corcoran","is_ca":false},{"name":"Bethany A. Freeman","is_ca":false},{"name":"Richard Zollner","is_ca":false},{"name":"Tod H. Marvell","is_ca":false},{"name":"Matthew D. Vera","is_ca":false},{"name":"Phaik‐Eng Sum","is_ca":false},{"name":"Edward R. LaVallie","is_ca":false},{"name":"Mark Stahl","is_ca":false},{"name":"W.S. Somers","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006585792474349516,"gpt":0.2475222432369744,"spread":0.2409364507626249,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003298567,0.0004554431,0.0004958334,0.0003768067,0.0005721704,0.0007646953,0.0007855757,0.0007845063,0.003276284],"category_scores_gemma":[0.0008659434,0.0004310213,0.0003149825,0.0005547418,0.0002522538,0.0006210746,0.0003170324,0.001521242,0.0005866362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001309835,"about_ca_system_score_gemma":0.0008722196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003840429,"about_ca_topic_score_gemma":0.004407506,"domain_scores_codex":[0.9997336,0.00003094579,0.00002016387,0.0000437949,0.0001355585,0.00003603461],"domain_scores_gemma":[0.9997041,0.00006004653,0.00007337254,0.00001576448,0.00008883753,0.0000579271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002308005,0.0008727322,0.01436701,0.001333576,0.0004612022,0.00167351,0.001477717,0.01682252,0.8335918,0.02759847,0.03922759,0.06026596],"study_design_scores_gemma":[0.001548052,0.001078912,0.06891078,0.0002398069,0.000827358,0.003664064,0.002055875,0.1082437,0.5055897,0.008954627,0.2986127,0.0002744315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548644,0.01275007,0.009863986,0.002110618,0.000292679,0.00009816186,0.00768104,0.0004715615,0.01186757],"genre_scores_gemma":[0.8994244,0.007262234,0.0367301,0.0004806593,0.00009026146,0.0001547596,0.03784108,0.000164632,0.01785189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003840429,"threshold_uncertainty_score":0.01096028,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4213335899","doi":"10.1039/d2cs00022a","title":"A guide to secondary coordination sphere editing","year":2022,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Coordination sphere; Chemistry; Computer science; Astrobiology; Physics; Crystallography","authors":[{"name":"Marcus W. Drover","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03232486925484181,"gpt":0.3309143626443292,"spread":0.2985894933894874,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006466127,0.0009996684,0.0009502043,0.001544967,0.0006221869,0.001569134,0.001953848,0.001393943,0.04083251],"category_scores_gemma":[0.0006427109,0.0007787892,0.0006477865,0.001271922,0.0008941793,0.001474839,0.001839001,0.003095865,0.04023312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009304814,"about_ca_system_score_gemma":0.0008853585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121252,"about_ca_topic_score_gemma":0.002380115,"domain_scores_codex":[0.9996831,0.00004901117,0.00003411353,0.0000692336,0.0001111682,0.00005342055],"domain_scores_gemma":[0.9998119,0.00006573279,0.00002459978,0.00002525626,0.00004380377,0.00002870766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006277869,0.00007849334,0.00005517979,0.004998568,0.00005127792,0.0004042769,0.0001460899,0.0005736806,0.01674609,0.03650768,0.3629265,0.5774494],"study_design_scores_gemma":[0.000005972569,0.00001360259,0.00003123279,0.0001159754,0.000003675069,0.0002385216,0.000005555866,0.00003181361,0.00145744,0.001837626,0.9962519,0.000006731246],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00137903,0.768559,0.06372118,0.004226433,0.01017935,0.0004379756,0.002955997,0.004742761,0.1437983],"genre_scores_gemma":[0.01737831,0.7304783,0.06143438,0.00602458,0.002296715,0.0009390588,0.00387011,0.0007206433,0.1768579],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04083251,"threshold_uncertainty_score":0.1365984,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2011397327","doi":"10.1023/b:jnmr.0000032611.72827.de","title":"Novel Techniques for Weak Alignment of Proteins in Solution Using Chemical Tags Coordinating Lanthanide Ions","year":2004,"lang":"en","type":"article","venue":"Journal of Biomolecular NMR","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Deutsche Forschungsgemeinschaft","keywords":"Lanthanide; Chemistry; Linker; Molecule; Ion; Residual dipolar coupling; Cysteine; Dipole; Tensor (intrinsic definition); Crystallography; Anisotropy; Computational chemistry; Organic chemistry; Enzyme","authors":[{"name":"Takahisa Ikegami","is_ca":false},{"name":"Laurent Verdier","is_ca":false},{"name":"Peyman Sakhaii","is_ca":false},{"name":"S. Grimme","is_ca":false},{"name":"Barbara Pescatore","is_ca":false},{"name":"Krishna Saxena","is_ca":false},{"name":"Klaus M. Fiebig","is_ca":true},{"name":"Christian Griesinger","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01469626097377189,"gpt":0.2778299830275384,"spread":0.2631337220537665,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001308695,0.0009457105,0.0006522848,0.0004584802,0.0007366942,0.001075006,0.001374881,0.0008764621,0.00165528],"category_scores_gemma":[0.001093967,0.0008848672,0.00041776,0.0004556854,0.0009735851,0.001378193,0.001469167,0.003413165,0.001110872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006030917,"about_ca_system_score_gemma":0.0004773706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003854094,"about_ca_topic_score_gemma":0.001197518,"domain_scores_codex":[0.9994233,0.0001216636,0.00004415273,0.0001375677,0.0001751608,0.00009819524],"domain_scores_gemma":[0.9990877,0.0003206439,0.0002310194,0.0001526182,0.0001118185,0.00009617279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005250106,0.000008577848,0.00004629311,0.00006198083,0.000006091336,0.00002835442,0.00003520277,0.00006155059,0.9965814,0.0005151628,0.0001239018,0.00247899],"study_design_scores_gemma":[0.00001202742,0.00003443152,0.00009382326,0.00000354812,0.000009720862,0.0001247374,0.00001712317,0.001097999,0.9957678,0.0001323162,0.002698387,0.000008005625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.360874,0.003693745,0.626003,0.001332039,0.0004934242,0.0002704143,0.000315247,0.002217915,0.004800284],"genre_scores_gemma":[0.5742675,0.003446345,0.4033912,0.0008633235,0.0001970558,0.0005283474,0.0009200546,0.0009235314,0.0154626],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00165528,"threshold_uncertainty_score":0.006921113,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2535582297","doi":"10.1021/acs.accounts.6b00403","title":"Multicomponent Hetero-[4 + 2] Cycloaddition/Allylboration Reaction: From Natural Product Synthesis to Drug Discovery","year":2016,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Alberta Cancer Board","keywords":"Cycloaddition; Chemistry; Piperidine; Allylic rearrangement; Natural product; Combinatorial chemistry; Tandem; Pyran; Drug discovery; Atom economy; Organic chemistry; Catalysis","authors":[{"name":"Dennis G. Hall","is_ca":true},{"name":"Taras Rybak","is_ca":true},{"name":"Tristan Verdelet","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02004657602919253,"gpt":0.3127472921198669,"spread":0.2927007160906744,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005419767,0.0007310013,0.0007502317,0.0008365661,0.0003412894,0.0008060602,0.0007668845,0.0008145199,0.001659063],"category_scores_gemma":[0.0002371444,0.0006833174,0.0005069045,0.0008958443,0.0007022156,0.001282869,0.001320167,0.001649814,0.001424782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005730636,"about_ca_system_score_gemma":0.0004643197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003380197,"about_ca_topic_score_gemma":0.0007189942,"domain_scores_codex":[0.9996196,0.00004314309,0.00002344294,0.0001367521,0.00009229033,0.00008479534],"domain_scores_gemma":[0.999915,0.00001589202,0.00001894381,0.00001216104,0.00001478422,0.00002317037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004061502,0.0003526853,0.0004734756,0.002175446,0.0001013222,0.0008243539,0.0004067096,0.00288625,0.72004,0.02639096,0.003757774,0.2421849],"study_design_scores_gemma":[0.0001012995,0.001405201,0.0009057181,0.0001432933,0.0001143775,0.001808906,0.00008919917,0.006496558,0.7923348,0.006852264,0.1896006,0.0001477816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2750133,0.2642828,0.3819795,0.002207528,0.001681837,0.001269634,0.000808527,0.002697932,0.07005905],"genre_scores_gemma":[0.7041083,0.1144705,0.1523188,0.001364908,0.0004917232,0.0006423827,0.0009846238,0.0002724916,0.02534649],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001659063,"threshold_uncertainty_score":0.005550146,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2794348009","doi":"10.1073/pnas.1711837115","title":"Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Protein Data Bank (RCSB PDB); Peptide; Protein Data Bank; Amino acid; Computational biology; Biochemistry; Function (biology); Peptide sequence; Chemistry; Protein structure; Biology; Genetics; Gene","authors":[{"name":"Michael Garton","is_ca":true},{"name":"Satra Nim","is_ca":true},{"name":"Tracy A. Stone","is_ca":true},{"name":"Kyle Ethan Wang","is_ca":true},{"name":"Charles M. Deber","is_ca":true},{"name":"Philip M. Kim","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04057533774553539,"gpt":0.3400738214502382,"spread":0.2994984837047028,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004978654,0.0005197042,0.0003945359,0.0006893204,0.0003194097,0.0005744266,0.000833683,0.000344589,0.007533756],"category_scores_gemma":[0.000784633,0.0004457019,0.000456379,0.0005693134,0.0001829429,0.0004419519,0.0008165443,0.0009912981,0.00371736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002990111,"about_ca_system_score_gemma":0.0004335986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004391705,"about_ca_topic_score_gemma":0.0005992833,"domain_scores_codex":[0.9997393,0.00002980439,0.0000358859,0.00007454825,0.0000912921,0.00002907765],"domain_scores_gemma":[0.9997225,0.00004706142,0.00004858051,0.00009553092,0.00005388465,0.00003240084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005261638,0.000337099,0.001513881,0.0003754697,0.00006232053,0.0005239974,0.0001283159,0.004293779,0.896468,0.004475038,0.006038372,0.08525756],"study_design_scores_gemma":[0.000209682,0.0006824699,0.0008111444,0.00002614144,0.00005530614,0.001008504,0.00006414383,0.03586032,0.9189022,0.001039356,0.04128639,0.00005427787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3192809,0.001394686,0.6440236,0.0005306652,0.0005438352,0.00233427,0.004753353,0.01065526,0.01648346],"genre_scores_gemma":[0.4826531,0.001164166,0.4960369,0.0002962798,0.00004521905,0.002009288,0.006390641,0.00121409,0.01019025],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007533756,"threshold_uncertainty_score":0.02520293,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2146790106","doi":"10.1021/ol051428b","title":"Boc-Protected Amines via a Mild and Efficient One-Pot Curtius Rearrangement","year":2005,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Curtius rearrangement; Chemistry; Carbamate; Sodium azide; Isocyanate; Malonate; Medicinal chemistry; Azide; Organic chemistry; Decarboxylation; Trifluoromethanesulfonate; Derivative (finance); Catalysis","authors":[{"name":"H. Lebel","is_ca":true},{"name":"Olivier Leogane","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006131466836369776,"gpt":0.1975657822224717,"spread":0.1914343153861019,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004705314,0.001356923,0.0007499708,0.0004689182,0.000462356,0.0002599791,0.001067433,0.000587307,0.003855272],"category_scores_gemma":[0.0004260878,0.0003701778,0.0004272151,0.0003632497,0.0004570089,0.0005622843,0.000918867,0.001177728,0.002466568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754993,"about_ca_system_score_gemma":0.0007599443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009093445,"about_ca_topic_score_gemma":0.002064712,"domain_scores_codex":[0.9995551,0.0000529295,0.00003543674,0.00009556329,0.0001152728,0.0001458156],"domain_scores_gemma":[0.9998312,0.00003062327,0.00003742272,0.00003352689,0.00002953793,0.00003760632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073582,0.00009738005,0.00006220589,0.000324062,0.00004019311,0.0005675799,0.0001036489,0.0003825027,0.9852138,0.001680097,0.00145202,0.00996916],"study_design_scores_gemma":[0.00007052792,0.0003785089,0.000560981,0.0000166549,0.00002715232,0.0007420984,0.00002077527,0.0008137743,0.9776382,0.00031061,0.01938381,0.00003688977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6993039,0.008868282,0.2115211,0.001774875,0.001342339,0.0028564,0.002308011,0.007560375,0.06446474],"genre_scores_gemma":[0.9217455,0.006699816,0.04736785,0.0005640535,0.0002007684,0.0008278701,0.001492621,0.0004769913,0.02062451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003855272,"threshold_uncertainty_score":0.01289713,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2331418330","doi":"10.1021/ol201475j","title":"A Remarkably Simple Protocol for the <i>N</i>-Formylation of Amino Acid Esters and Primary Amines","year":2011,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"Formylation; Chemistry; Primary (astronomy); Simple (philosophy); Protocol (science); Amino acid; Combinatorial chemistry; Organic chemistry; Biochemistry; Catalysis","authors":[{"name":"Mojmı́r Suchý","is_ca":true},{"name":"Adam A. H. Elmehriki","is_ca":true},{"name":"Robert H. E. Hudson","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01494289897177283,"gpt":0.230318529922611,"spread":0.2153756309508382,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005675412,0.001046591,0.0005996513,0.000353363,0.0005118182,0.0003532555,0.001006583,0.0005784126,0.003719209],"category_scores_gemma":[0.0003937246,0.0004254656,0.0004551497,0.0003490314,0.0003360409,0.0007076872,0.0006753551,0.001367423,0.00238721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000350717,"about_ca_system_score_gemma":0.0007815314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005600223,"about_ca_topic_score_gemma":0.001149961,"domain_scores_codex":[0.9996536,0.00006621144,0.00004000164,0.00009002016,0.00009299533,0.00005724819],"domain_scores_gemma":[0.9998628,0.00002699167,0.00002903341,0.00003029206,0.00002516344,0.00002567188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007942478,0.00004987907,0.00005161541,0.0003538526,0.00001829348,0.0002439534,0.00005212844,0.0002543225,0.9805549,0.001370128,0.001540357,0.01543113],"study_design_scores_gemma":[0.00003503081,0.0002235644,0.0003326088,0.00001589944,0.00001909499,0.0008053352,0.00001541712,0.0003698225,0.958629,0.0004494376,0.03906181,0.00004286247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1706959,0.009267191,0.767366,0.0009072936,0.001211463,0.002281648,0.003322087,0.003072555,0.0418758],"genre_scores_gemma":[0.5015491,0.0191704,0.4154027,0.0009352777,0.000304489,0.003336121,0.006360855,0.0008518188,0.05208934],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003719209,"threshold_uncertainty_score":0.01244199,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2313299612","doi":"10.1021/ja508588b","title":"Pd-Catalyzed Chemoselective Carbonylation of Aminophenols with Iodoarenes: Alkoxycarbonylation vs Aminocarbonylation","year":2014,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Carbonylation; Propane; Ligand (biochemistry); Catalysis; Base (topology); Palladium; Medicinal chemistry; Organic chemistry; Combinatorial chemistry; Carbon monoxide; Receptor","authors":[{"name":"Tongyu Xu","is_ca":true},{"name":"Howard Alper","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004290905189930806,"gpt":0.2112143133279358,"spread":0.206923408138005,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002450597,0.0005674509,0.0002396402,0.0002110273,0.0001602352,0.0001810675,0.0003631339,0.0003451255,0.001011431],"category_scores_gemma":[0.0002158609,0.0002118195,0.0002627684,0.000318714,0.0002659634,0.0003584318,0.0004062614,0.0005615395,0.0005931796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003260918,"about_ca_system_score_gemma":0.0003972252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006486968,"about_ca_topic_score_gemma":0.001393282,"domain_scores_codex":[0.9998292,0.00002157363,0.00001110221,0.00004316375,0.0000434316,0.00005159692],"domain_scores_gemma":[0.9998733,0.00002107664,0.00003360943,0.00001821757,0.00002728891,0.00002655278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005948352,0.00001373717,0.00004916481,0.00004130726,0.000004683174,0.00006809511,0.00001320971,0.00006890726,0.9982235,0.000121636,0.00002382141,0.00131254],"study_design_scores_gemma":[0.000004258071,0.00003718193,0.0001428466,0.000001233539,0.000003095754,0.00005997732,0.000003081827,0.00009153678,0.9990109,0.00001094856,0.0006326395,0.000002193201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686923,0.00185584,0.02154968,0.0001588921,0.00007214475,0.0001182972,0.0004346928,0.0002257196,0.006892374],"genre_scores_gemma":[0.982084,0.001906538,0.01104909,0.00008308101,0.00001954757,0.00006302237,0.00041472,0.00005991026,0.004320046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011431,"threshold_uncertainty_score":0.003383577,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2112613432","doi":"10.1002/bip.22327","title":"Analysis of <i>N</i>‐amino‐imidazolin‐2‐one peptide turn mimic 4‐position substituent effects on conformation by X‐ray crystallography","year":2013,"lang":"en","type":"article","venue":"Biopolymers","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Dihedral angle; Substituent; Chemistry; Tetrapeptide; Side chain; Conformational isomerism; Turn (biochemistry); Peptide; Residue (chemistry); Stereochemistry; Amino acid; Crystallography; Molecule; Organic chemistry","authors":[{"name":"Caroline Proulx","is_ca":true},{"name":"William D. Lubell","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003432874934936863,"gpt":0.1948416341838798,"spread":0.191408759248943,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217254,0.0002459672,0.0001958888,0.00008312987,0.00009312035,0.0001746224,0.0001687185,0.0001750473,0.0009166263],"category_scores_gemma":[0.0003254895,0.0001165064,0.000157806,0.0001110525,0.000138967,0.0001187767,0.00007783977,0.000264413,0.000157047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178481,"about_ca_system_score_gemma":0.0001220558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008180786,"about_ca_topic_score_gemma":0.0009227694,"domain_scores_codex":[0.9999119,0.00002031913,0.000005097077,0.00001265924,0.00002993034,0.00002001021],"domain_scores_gemma":[0.9998317,0.00005828018,0.00005030374,0.0000126564,0.00002829999,0.00001881891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000154226,0.00001139972,0.0002612085,0.00002081858,0.000005517679,0.00005431377,0.0000147727,0.000696589,0.9980301,0.00003917215,0.00001616184,0.0006957083],"study_design_scores_gemma":[0.00001625664,0.0002928467,0.002446188,0.000003552476,0.00001436873,0.00006499229,0.00002398318,0.003174419,0.9933742,0.00001984977,0.0005630829,0.000006409091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982373,0.0002585267,0.0007403348,0.00001654065,0.000003833746,0.000007770982,0.00009715744,0.00001251269,0.0006260886],"genre_scores_gemma":[0.9979085,0.0002449014,0.001178981,0.00001298405,0.000001526042,0.0000121615,0.0001981132,0.00001167212,0.000431223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009166263,"threshold_uncertainty_score":0.003066421,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2006383598","doi":"10.1021/ol027160v","title":"Synthesis of Biologically Active Dicarba Analogues of the Peptide Hormone Oxytocin Using Ring-Closing Metathesis","year":2002,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Ring-closing metathesis; Oxytocin; Peptide; Biological activity; Metathesis; Combinatorial chemistry; Salt metathesis reaction; Stereochemistry; Hormone; Closing (real estate); Peptide hormone; Ring (chemistry); Cyclic peptide; Biochemistry; Organic chemistry; In vitro; Endocrinology; Biology","authors":[{"name":"Jake L. Stymiest","is_ca":true},{"name":"B.F. Mitchell","is_ca":true},{"name":"Susan Wong","is_ca":true},{"name":"John C. Vederas","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01435491262377082,"gpt":0.207611111406962,"spread":0.1932561987831912,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372393,0.0004287768,0.0003330313,0.0001808747,0.0001816452,0.0002548812,0.0004173345,0.0003709875,0.002944766],"category_scores_gemma":[0.0002439745,0.0002223861,0.0002828193,0.0001649679,0.0002135114,0.0002601381,0.0003177153,0.0005750749,0.0008765344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829935,"about_ca_system_score_gemma":0.0001741535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001906478,"about_ca_topic_score_gemma":0.0003868998,"domain_scores_codex":[0.9998416,0.00002460501,0.00001751685,0.00004343359,0.00003172467,0.00004116691],"domain_scores_gemma":[0.9998653,0.00002057745,0.00003933759,0.0000209086,0.00001872013,0.00003518476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130278,0.00002565643,0.00005332414,0.00009879213,0.00001034272,0.0001268624,0.00003150439,0.0001453435,0.9950756,0.0004799537,0.00009299577,0.003729349],"study_design_scores_gemma":[0.00004456822,0.0008514858,0.0004945759,0.000006158752,0.00002242053,0.0003986655,0.00001322555,0.0002093485,0.9916868,0.00008278624,0.006177455,0.00001255446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680551,0.005308013,0.01144312,0.000248603,0.0001997587,0.0001659083,0.0007807856,0.0002486945,0.01355009],"genre_scores_gemma":[0.9791331,0.002341232,0.01264233,0.000121757,0.00004313112,0.00007545177,0.0005547499,0.00004803462,0.005040269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002944766,"threshold_uncertainty_score":0.009851217,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3047282804","doi":"10.1021/acssuschemeng.0c03816","title":"Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion","year":2020,"lang":"en","type":"article","venue":"ACS Sustainable Chemistry & Engineering","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Queen's University; Centre National de la Recherche Scientifique; Queen's University Belfast","keywords":"Active ingredient; Extrusion; Hydrazone; Solvent; Hydantoin; Chemistry; Combinatorial chemistry; Organic chemistry; Materials science; Medicine; Pharmacology","authors":[{"name":"Deborah E. Crawford","is_ca":false},{"name":"Andrea Porcheddu","is_ca":false},{"name":"Aaron S. McCalmont","is_ca":false},{"name":"Francesco Delogu","is_ca":false},{"name":"Stuart L. James","is_ca":false},{"name":"Evelina Colacino","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004850844937908003,"gpt":0.2075470831002062,"spread":0.2026962381622982,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002964569,0.0003817735,0.0003071618,0.0002352735,0.0001744285,0.0004201849,0.0003243032,0.0003171953,0.001704774],"category_scores_gemma":[0.000232828,0.000224518,0.0003156505,0.0002990684,0.0002147409,0.0006148897,0.0002953333,0.0005652237,0.0007989808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001785842,"about_ca_system_score_gemma":0.0001991309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001390607,"about_ca_topic_score_gemma":0.0004058269,"domain_scores_codex":[0.9998353,0.00001794206,0.00001485085,0.00004203307,0.00006640732,0.00002345893],"domain_scores_gemma":[0.9998996,0.00003067436,0.00002905234,0.00001302986,0.0000167599,0.00001082589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000723588,0.00001887945,0.00003183692,0.00006595095,0.000003995779,0.00003260742,0.00002105069,0.0001411672,0.9951094,0.0002659619,0.00004267834,0.004194004],"study_design_scores_gemma":[0.00001144029,0.00009139006,0.0001661584,0.000002633606,0.000005433772,0.00002267166,0.000005397062,0.0005816675,0.9976702,0.00003233118,0.001406438,0.000004203296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9109765,0.002346362,0.07983873,0.0001112806,0.0001039271,0.0001389921,0.0006913097,0.0004522467,0.005340632],"genre_scores_gemma":[0.9453261,0.001695129,0.04609909,0.00003651142,0.00002948526,0.0000670449,0.0003743276,0.0001159149,0.006256297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704774,"threshold_uncertainty_score":0.005703092,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2026975505","doi":"10.1139/v00-089","title":"The Suzuki, the Heck, and the Stille reaction - three versatile methods for the introduction of new C-C bonds on solid support","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"","keywords":"Stille reaction; Chemistry; Heck reaction; Suzuki reaction; Coupling reaction; Solid-phase synthesis; Combinatorial chemistry; Molecule; Catalysis; Organic chemistry; Palladium","authors":[{"name":"Robert Franzén","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008696512959411713,"gpt":0.2653066845734699,"spread":0.2566101716140582,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009464911,0.001863608,0.001050343,0.001912477,0.0008737614,0.0008861751,0.00105488,0.0009437834,0.002764539],"category_scores_gemma":[0.0006994078,0.0006283566,0.000963892,0.00124631,0.001166428,0.001457801,0.001307412,0.001920275,0.002677399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005761476,"about_ca_system_score_gemma":0.0007140239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005942389,"about_ca_topic_score_gemma":0.001540569,"domain_scores_codex":[0.9991764,0.0001409817,0.00005904457,0.000137714,0.0003454783,0.0001403109],"domain_scores_gemma":[0.9997783,0.00006241201,0.00005476838,0.00003608326,0.00003357282,0.00003479889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007012532,0.0003475701,0.00084278,0.004614237,0.0004236249,0.001368497,0.0004232602,0.00223048,0.4744893,0.04006268,0.007905175,0.4665912],"study_design_scores_gemma":[0.0000783607,0.001343245,0.0009493848,0.0000805155,0.0001270984,0.002653161,0.0001159308,0.0008685273,0.8071703,0.004594389,0.1818345,0.0001846495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.1494469,0.4686826,0.295492,0.001998791,0.003226262,0.00189963,0.002066858,0.003005183,0.07418188],"genre_scores_gemma":[0.4688289,0.2785216,0.1812601,0.001146792,0.0008307325,0.001570926,0.001668161,0.0002362341,0.06593654],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002764539,"threshold_uncertainty_score":0.009248376,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2314443567","doi":"10.1021/ol201005s","title":"Efficient and Controllably Selective Preparation of Esters Using Uronium-Based Coupling Agents","year":2011,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Reagent; Phenol; Selectivity; Alcohol; Primary (astronomy); Coupling (piping); Coupling reaction; Combinatorial chemistry; Base (topology); Tertiary alcohols; Organic chemistry; Catalysis","authors":[{"name":"Jean–d’Amour K. Twibanire","is_ca":true},{"name":"T. Bruce Grindley","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.011925492212328,"gpt":0.2317168107753109,"spread":0.219791318562983,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004421323,0.0008155485,0.0004867894,0.0003524048,0.0002109362,0.0004251776,0.0004509264,0.0004145595,0.001617059],"category_scores_gemma":[0.0004822217,0.0004424449,0.0002969562,0.0003445353,0.0002337758,0.0006739239,0.000598919,0.0005983385,0.001431321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224965,"about_ca_system_score_gemma":0.0002937991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002059306,"about_ca_topic_score_gemma":0.00039739,"domain_scores_codex":[0.9997347,0.00004938201,0.00003415982,0.00005830832,0.00005519505,0.00006823503],"domain_scores_gemma":[0.9997868,0.00003603184,0.00006435119,0.00003395998,0.00003423512,0.00004470333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006326424,0.00001171348,0.00004254276,0.00009352158,0.000005552844,0.0001055635,0.00001868239,0.00007990603,0.9950178,0.0002211205,0.00006304795,0.004277314],"study_design_scores_gemma":[0.00000573754,0.00002994159,0.00006349034,0.000004254679,0.00000415459,0.00006449232,0.000003338886,0.0001048737,0.9979399,0.00002178883,0.001754459,0.000003488603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8497515,0.009497279,0.1236218,0.0003586903,0.0003212027,0.0004793565,0.0006267421,0.000835126,0.01450825],"genre_scores_gemma":[0.9109978,0.008977759,0.06340504,0.0002581183,0.00008497832,0.0003141151,0.000606649,0.0003007369,0.01505488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617059,"threshold_uncertainty_score":0.005409539,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2069196817","doi":"10.1021/ar8000052","title":"The Practice of Ring Constraint in Peptidomimetics Using Bicyclic and Polycyclic Amino Acids","year":2008,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Peptidomimetic; Chemistry; Small molecule; Combinatorial chemistry; Amino acid; Drug discovery; Proteolysis; Proteolytic enzymes; Stereochemistry; Computational biology; Enzyme; Peptide; Biochemistry; Biology","authors":[{"name":"Stephen Hanessian","is_ca":true},{"name":"Luciana Auzzas","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04400918178875081,"gpt":0.3654493752804204,"spread":0.3214401934916696,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000944095,0.0005571688,0.0005813517,0.000543508,0.0005285746,0.0008934346,0.0008718303,0.0008214889,0.003485156],"category_scores_gemma":[0.001601707,0.0004287531,0.0004386636,0.0009082205,0.00176666,0.001448525,0.001264232,0.0019527,0.001727747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006212685,"about_ca_system_score_gemma":0.0006437163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004265349,"about_ca_topic_score_gemma":0.0005155932,"domain_scores_codex":[0.9992164,0.0002005111,0.0001066159,0.0002076374,0.0001945408,0.00007424241],"domain_scores_gemma":[0.9994262,0.0002025766,0.0001326133,0.0001505913,0.00005097262,0.00003700971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008927874,0.0002341505,0.0004580737,0.003404448,0.00009715263,0.001319458,0.0006120871,0.02218368,0.3386726,0.352245,0.005772633,0.274108],"study_design_scores_gemma":[0.0003611806,0.003552793,0.0004846176,0.0004887661,0.00009936649,0.002915733,0.0001553552,0.01941474,0.3498486,0.06855288,0.5538433,0.000282707],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1569994,0.1394352,0.5900539,0.003812977,0.002942717,0.0008436808,0.0008580759,0.001910477,0.1031437],"genre_scores_gemma":[0.5644077,0.05476181,0.3604051,0.002745261,0.0007112874,0.0009656369,0.0005420599,0.0004094314,0.01505158],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003485156,"threshold_uncertainty_score":0.01165897,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2004433174","doi":"10.1002/chem.200600735","title":"An Easy‐To‐Use, Regioselective, and Robust Bis(amidate) Titanium Hydroamination Precatalyst: Mechanistic and Synthetic Investigations toward the Preparation of Tetrahydroisoquinolines and Benzoquinolizine Alkaloids","year":2006,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hydroamination; Regioselectivity; Combinatorial chemistry; Titanium; Chemistry; Organic chemistry; Catalysis","authors":[{"name":"Zhe Zhang","is_ca":true},{"name":"David C. Leitch","is_ca":true},{"name":"Man Lu","is_ca":true},{"name":"Brian O. Patrick","is_ca":true},{"name":"Laurel L. Schafer","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01283672062913167,"gpt":0.2274729264777372,"spread":0.2146362058486055,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882682,0.0003473685,0.0001637034,0.0001512914,0.0001331022,0.0002166359,0.0004147208,0.0003448946,0.0005367436],"category_scores_gemma":[0.0002087175,0.0001837436,0.0002056602,0.00008200436,0.0001975902,0.0002199293,0.0002418251,0.000401598,0.0003847085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119617,"about_ca_system_score_gemma":0.0001842928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002998855,"about_ca_topic_score_gemma":0.0006660225,"domain_scores_codex":[0.999876,0.00001327049,0.00001224117,0.00002656131,0.00005113815,0.00002066692],"domain_scores_gemma":[0.9998871,0.00001683908,0.00004412993,0.00001350248,0.00002278666,0.00001565353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001585224,0.000008573701,0.00003726537,0.00003366948,0.000003230367,0.000038876,0.00001305665,0.00005604116,0.998421,0.00008130568,0.00001635086,0.001274919],"study_design_scores_gemma":[0.000005212661,0.0001153833,0.0003076307,0.000001644724,0.000005547939,0.0001532676,0.000005692475,0.000200492,0.9981165,0.00001396766,0.001070682,0.000003922255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971364,0.002425956,0.02199099,0.0001554688,0.00003822199,0.0001423865,0.0002663353,0.0002439769,0.003372717],"genre_scores_gemma":[0.983166,0.001143144,0.01304424,0.0000321786,0.0000106225,0.0000343533,0.000243402,0.00003684482,0.002289196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005367436,"threshold_uncertainty_score":0.00179559,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2623628426","doi":"10.1021/acs.accounts.7b00114","title":"Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications","year":2017,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Peptidomimetic; Peptide synthesis; Combinatorial chemistry; Semicarbazide; Amino acid; Peptide; Alkylation; Stereochemistry; Organic chemistry; Biochemistry","authors":[{"name":"Ramesh Chingle","is_ca":true},{"name":"Caroline Proulx","is_ca":true},{"name":"William D. Lubell","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0908443478881088,"gpt":0.481868682635525,"spread":0.3910243347474162,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003245701,0.0005914808,0.0002757777,0.0004113096,0.000183924,0.0002884081,0.00032694,0.0003572508,0.003423622],"category_scores_gemma":[0.000302522,0.0002271127,0.0002727406,0.0003512891,0.0002216601,0.0005947029,0.0003982882,0.001154177,0.001948112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003984981,"about_ca_system_score_gemma":0.0002430437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001827748,"about_ca_topic_score_gemma":0.0004685447,"domain_scores_codex":[0.9998176,0.00002534819,0.00002008909,0.00005786852,0.00005351698,0.00002557267],"domain_scores_gemma":[0.9998794,0.0000280698,0.00003597996,0.00001803016,0.00002669236,0.00001181868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007089763,0.00004191206,0.00007690604,0.0004117703,0.00001550819,0.0001653402,0.00005088452,0.0006616732,0.9677537,0.005143071,0.0009209164,0.02468742],"study_design_scores_gemma":[0.00005180616,0.0004313799,0.0003688504,0.00004194615,0.00002508419,0.0004927855,0.00001746303,0.001915109,0.937139,0.001395985,0.05809618,0.00002431046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.347991,0.07425772,0.5043429,0.00198317,0.001333655,0.0009388624,0.002245578,0.001925683,0.06498139],"genre_scores_gemma":[0.7576128,0.0459289,0.171854,0.001168595,0.0003056282,0.000945513,0.001509615,0.0002784069,0.02039649],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003423622,"threshold_uncertainty_score":0.01145321,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2316075424","doi":"10.1021/ar400210c","title":"Air- and Moisture-Stable Amphoteric Molecules: Enabling Reagents in Synthesis","year":2014,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto","keywords":"Aziridine; Nucleophile; Electrophile; Aldehyde; Chemistry; Hemiaminal; Combinatorial chemistry; Molecule; Organic chemistry; Nucleophilic addition; Amine gas treating; Ring (chemistry); Catalysis","authors":[{"name":"Zhi He","is_ca":true},{"name":"Adam Zajdlik","is_ca":true},{"name":"Andrei K. Yudin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02114739337771209,"gpt":0.3100841494403328,"spread":0.2889367560626207,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007321404,0.0005764263,0.0002060143,0.0005393308,0.0001790614,0.0004699861,0.0004764518,0.0004998901,0.001586471],"category_scores_gemma":[0.0002908901,0.0003682384,0.0002138231,0.0002874553,0.0005296466,0.001119253,0.0007003883,0.0008967944,0.001196161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003486556,"about_ca_system_score_gemma":0.000210721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001918408,"about_ca_topic_score_gemma":0.0002445788,"domain_scores_codex":[0.9997588,0.00004554507,0.0000213407,0.00005014662,0.00008122424,0.00004295428],"domain_scores_gemma":[0.999879,0.00002704031,0.00002838945,0.00001591119,0.00001738825,0.00003223851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008760366,0.0001268771,0.0002923567,0.0004485631,0.00001480064,0.0002567934,0.000200628,0.0008407074,0.9326823,0.01883752,0.0006075272,0.04560437],"study_design_scores_gemma":[0.00005521454,0.0007461723,0.0005094486,0.0000801586,0.00002129796,0.0005919102,0.00005140949,0.001142939,0.9211738,0.002575685,0.07300696,0.00004508397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4883271,0.1247345,0.3103104,0.001757329,0.0006902298,0.0008753698,0.001262457,0.002013996,0.0700286],"genre_scores_gemma":[0.7659013,0.05220729,0.1700519,0.0005506839,0.0002264964,0.0003723981,0.0004453868,0.0001559467,0.01008856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586471,"threshold_uncertainty_score":0.005307257,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2280289181","doi":"10.1039/c5sc03856a","title":"Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Ferring Research Institute; Alberta Glycomics Centre; Royal Society of Chemistry; Royal Society","keywords":"Chemistry; Combinatorial chemistry; Nucleophile; Peptide; Nucleophilic aromatic substitution; Amino acid; Cyclic peptide; Reactivity (psychology); Aqueous solution; Stereochemistry; Nucleophilic substitution; Organic chemistry; Biochemistry","authors":[{"name":"Shiva Kalhor‐Monfared","is_ca":true},{"name":"Mohammad Reza Jafari","is_ca":true},{"name":"James T Patterson","is_ca":false},{"name":"Pavel I. Kitov","is_ca":true},{"name":"John J. Dwyer","is_ca":false},{"name":"John M. Nuss","is_ca":false},{"name":"Ratmir Derda","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006750143431886737,"gpt":0.2188010880875681,"spread":0.2120509446556813,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848202,0.0004033858,0.0001427718,0.0001932996,0.0002064792,0.0002010795,0.0001568968,0.0002572751,0.001651612],"category_scores_gemma":[0.0001885805,0.0001248708,0.0001264511,0.0001317786,0.0001912941,0.0002266707,0.0001875179,0.0003283419,0.0005428779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757955,"about_ca_system_score_gemma":0.0002741881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004607539,"about_ca_topic_score_gemma":0.001306362,"domain_scores_codex":[0.9998857,0.00001988702,0.000008582258,0.00003032472,0.00002364842,0.00003194168],"domain_scores_gemma":[0.9999114,0.00001780885,0.00002801582,0.00001063935,0.000008466997,0.00002360915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009116323,0.00001208006,0.00006603223,0.0000378017,0.000003036558,0.00007175171,0.00001622699,0.000102859,0.994144,0.0002677809,0.0001793679,0.005007807],"study_design_scores_gemma":[0.00001376478,0.0002192373,0.0006433768,0.000004234907,0.000004207917,0.0001767004,0.00000623686,0.0002515225,0.993687,0.00004510118,0.004942147,0.000006505973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509006,0.008817885,0.02923051,0.0003667137,0.0003349792,0.0003004397,0.000767759,0.0004630124,0.008818213],"genre_scores_gemma":[0.9719436,0.002837773,0.01696067,0.0001710903,0.00004506081,0.0001318063,0.0006447249,0.00007629832,0.007188964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651612,"threshold_uncertainty_score":0.005525231,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2032883295","doi":"10.1021/jo0106501","title":"Universal Solid-Phase Approach for the Immobilization, Derivatization, and Resin-to-Resin Transfer Reactions of Boronic Acids","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"China Scholarship Council","keywords":"Derivatization; Chemistry; Diethanolamine; Boronic acid; Hydrolysis; Anhydrous; Organic chemistry; Combinatorial chemistry; High-performance liquid chromatography","authors":[{"name":"Michel Gravel","is_ca":true},{"name":"Kim A. Thompson","is_ca":true},{"name":"Mark Zak","is_ca":true},{"name":"C.D. Berube","is_ca":true},{"name":"Dennis G. Hall","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008970780861471067,"gpt":0.2630827769267954,"spread":0.2541119960653243,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005409053,0.001212072,0.0006246524,0.0006164528,0.0003575962,0.0003154646,0.000777728,0.0007876104,0.001856394],"category_scores_gemma":[0.0003212714,0.0004984311,0.0005810315,0.000471581,0.0004295591,0.0003497314,0.0007147592,0.001148121,0.002238877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004317708,"about_ca_system_score_gemma":0.0005487441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002153154,"about_ca_topic_score_gemma":0.0005730254,"domain_scores_codex":[0.9995031,0.00009465396,0.00003562842,0.0001282913,0.0001643883,0.00007382745],"domain_scores_gemma":[0.9998199,0.00003775676,0.00004411897,0.00004131555,0.00003316975,0.00002375237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003715343,0.00004340631,0.00004259401,0.0002586284,0.00001287938,0.00006496601,0.00002810665,0.0001482895,0.9891599,0.0008181643,0.0001910676,0.009194852],"study_design_scores_gemma":[0.000009249678,0.0001734853,0.0001800923,0.000008976543,0.00001045902,0.0002478736,0.000008686484,0.0007130121,0.9897019,0.0001709803,0.008764007,0.00001136242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.318435,0.01880154,0.6451679,0.0003852945,0.0004606778,0.001385814,0.001347155,0.002832482,0.01118424],"genre_scores_gemma":[0.6095595,0.01272568,0.3645694,0.0003412847,0.0001180786,0.001128933,0.002357761,0.0002298263,0.00896951],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001856394,"threshold_uncertainty_score":0.006210208,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2055939327","doi":"10.1038/srep09344","title":"Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; In vivo; Phenotype; Biochemistry; Cell biology; Biology; Gene; Genetics","authors":[{"name":"Yingmin Zhu","is_ca":false},{"name":"Haijun Chen","is_ca":false},{"name":"Stephen Boulton","is_ca":true},{"name":"Fang Mei","is_ca":false},{"name":"Na Ye","is_ca":false},{"name":"Giuseppe Melacini","is_ca":true},{"name":"Jia Zhou","is_ca":false},{"name":"Xiaodong Cheng","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01801978423264054,"gpt":0.2653207138840368,"spread":0.2473009296513962,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002527064,0.0003928495,0.0003107373,0.0001513402,0.0001063171,0.0001533068,0.0002068258,0.0002739308,0.00153924],"category_scores_gemma":[0.0001509376,0.0001187015,0.0002518047,0.0001160454,0.0001536312,0.0002030716,0.0001109927,0.000696859,0.0005526245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000190096,"about_ca_system_score_gemma":0.0001708894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002048264,"about_ca_topic_score_gemma":0.0003598042,"domain_scores_codex":[0.9999429,0.00001049663,0.000005514175,0.00001257454,0.00001667205,0.00001183578],"domain_scores_gemma":[0.999934,0.00001460955,0.00001650088,0.000005824344,0.00001384362,0.00001528029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001598188,0.00006466339,0.00004869272,0.00004695415,0.000008024455,0.00003284913,0.000008140412,0.0001461767,0.9964399,0.00008323517,0.00007560579,0.00288598],"study_design_scores_gemma":[0.00002829411,0.0008941574,0.0008510984,0.000005382216,0.00001685544,0.0001485446,0.000006277644,0.0005970904,0.9949942,0.00004104687,0.002411514,0.0000054995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631993,0.00989123,0.01910633,0.0004166005,0.00007908814,0.0002446085,0.001792993,0.0001868826,0.005082966],"genre_scores_gemma":[0.9671058,0.00782622,0.01737995,0.0004046308,0.0000497755,0.0002315841,0.0024901,0.00003518058,0.004476796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153924,"threshold_uncertainty_score":0.005149245,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2089708297","doi":"10.1002/1097-0282(2000)55:2<101::aid-bip20>3.0.co;2-o","title":"Design, synthesis, and conformational analysis of azacycloalkane amino acids as conformationally constrained probes for mimicry of peptide secondary structures","year":2000,"lang":"en","type":"review","venue":"Biopolymers","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Dipeptide; Chemistry; Amino acid; Peptide; Mimicry; Combinatorial chemistry; Stereochemistry; Peptide synthesis; Biochemistry","authors":[{"name":"Liliane Halab","is_ca":true},{"name":"Francis Gosselin","is_ca":true},{"name":"William D. Lubell","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01657277017405413,"gpt":0.2790901985528438,"spread":0.2625174283787897,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003185706,0.0007160307,0.0005316949,0.0006077323,0.0002052849,0.0005307923,0.000565633,0.0004929474,0.0007903188],"category_scores_gemma":[0.0001990187,0.0002395717,0.0001746097,0.000782581,0.0004094765,0.0005738146,0.000258158,0.000720172,0.001056465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008094913,"about_ca_system_score_gemma":0.0003864025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006611544,"about_ca_topic_score_gemma":0.001076384,"domain_scores_codex":[0.9998719,0.00002058634,0.000009328235,0.00003468671,0.00004773285,0.0000158814],"domain_scores_gemma":[0.9999444,0.00001590098,0.00001253696,0.000006056931,0.00001435865,0.000006750747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009985432,0.0001160763,0.0002049083,0.003872454,0.00003384702,0.0005921588,0.0001091887,0.003508447,0.5413527,0.017913,0.002704642,0.4294928],"study_design_scores_gemma":[0.00004758124,0.0003690947,0.0007070895,0.0002206104,0.0000469288,0.001811145,0.0000480579,0.001257426,0.571787,0.00309246,0.4205746,0.00003798844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04483612,0.8977821,0.03540359,0.0005678958,0.0004364719,0.0001899019,0.0001407362,0.000125721,0.02051741],"genre_scores_gemma":[0.09691624,0.8621168,0.02567006,0.0003661699,0.0001258655,0.0002163107,0.0002331176,0.00003159878,0.01432397],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008094913,"threshold_uncertainty_score":0.005873322,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1981628065","doi":"10.1021/cb3006227","title":"Computational Design of Enone-Binding Proteins with Catalytic Activity for the Morita–Baylis–Hillman Reaction","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; Howard Hughes Medical Institute","keywords":"Enone; Catalysis; Morita therapy; Chemistry; Biology; Stereochemistry; Biochemistry; Mathematics; Pure mathematics","authors":[{"name":"Sinisa Bjelic","is_ca":false},{"name":"Lucas G. Nivón","is_ca":true},{"name":"Nihan Çelebi‐Ölçüm","is_ca":false},{"name":"Gert Kiss","is_ca":false},{"name":"Carolyn F. Rosewall","is_ca":true},{"name":"Helena M. Lovick","is_ca":true},{"name":"Erica L. Ingalls","is_ca":true},{"name":"Jasmine L. Gallaher","is_ca":true},{"name":"J. Seetharaman","is_ca":false},{"name":"Scott Lew","is_ca":false},{"name":"G.T. Montelione","is_ca":false},{"name":"J.F. Hunt","is_ca":false},{"name":"Forrest E. Michael","is_ca":true},{"name":"K. N. Houk","is_ca":false},{"name":"David Baker","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01499336925079736,"gpt":0.2428054390793648,"spread":0.2278120698285674,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005716414,0.0007034711,0.0009164818,0.0005095002,0.0004186522,0.0007616216,0.001123328,0.001054667,0.001503292],"category_scores_gemma":[0.00114065,0.0005498608,0.0005482511,0.0003279661,0.0004407476,0.0003586292,0.0003560241,0.0005738895,0.000187329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001184296,"about_ca_system_score_gemma":0.001786982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004213941,"about_ca_topic_score_gemma":0.005655592,"domain_scores_codex":[0.9999164,0.00002716944,0.000003891873,0.00001646907,0.00001418037,0.00002179053],"domain_scores_gemma":[0.9997477,0.0001598404,0.00001777092,0.000009484877,0.00003077793,0.00003450319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002907123,0.0001467992,0.002065158,0.0001349533,0.00007214978,0.0002566298,0.00004199162,0.9815338,0.004659669,0.004378255,0.0006997336,0.005720162],"study_design_scores_gemma":[0.00009492,0.00005890284,0.0002026351,0.000005222463,0.0000218561,0.00001270939,0.00002940675,0.9971402,0.001223722,0.0007636844,0.0004422877,0.000004546736],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658018,0.0005418274,0.02736289,0.0005302829,0.00005116035,0.0001346112,0.0003697145,0.0003090813,0.00489868],"genre_scores_gemma":[0.9238238,0.000340215,0.07276328,0.0001685765,0.00001508285,0.0003902918,0.0008604863,0.00008722546,0.001551059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004213941,"threshold_uncertainty_score":0.008592725,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2106927509","doi":"10.1006/jmbi.1999.3352","title":"A heterodimeric coiled-coil peptide pair selected in vivo from a designed library- versus -library ensemble 1 1Edited by A. R. Fersht","year":2000,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences","keywords":"In vivo; Template; Coiled coil; Biology; Rational design; DNA; Complementation; Protein-fragment complementation assay; Computational biology; Peptide; Genetics; Biophysics; Biochemistry; Phenotype; Nanotechnology; Gene; Materials science","authors":[{"name":"Katja M. Arndt","is_ca":false},{"name":"Joelle N. Pelletier","is_ca":true},{"name":"Kristian M. Müller","is_ca":false},{"name":"Tom Alber","is_ca":false},{"name":"Stephen W. Michnick","is_ca":true},{"name":"Andreas Plückthun","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004907902148978285,"gpt":0.2138979249714543,"spread":0.208990022822476,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006219151,0.0004334652,0.0006558642,0.0003351842,0.0004606788,0.0004678281,0.000334437,0.0003733232,0.003316036],"category_scores_gemma":[0.0003196735,0.0002268281,0.0002119343,0.0003792157,0.000219888,0.0002724433,0.0003977853,0.0006041408,0.001180894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002949031,"about_ca_system_score_gemma":0.0002241841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001591459,"about_ca_topic_score_gemma":0.0005075384,"domain_scores_codex":[0.999508,0.00009349138,0.00002640977,0.0001765058,0.0001064569,0.00008907288],"domain_scores_gemma":[0.9997415,0.00004594564,0.00002774943,0.00003269931,0.00003702653,0.0001150337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158519,0.00005180444,0.0001895088,0.00001834929,0.00001033084,0.00003458929,0.00001329539,0.0001762681,0.9975889,0.0001069366,0.0001343436,0.00155989],"study_design_scores_gemma":[0.00002604098,0.0003782804,0.0006972993,0.000002799645,0.00001862354,0.0001463461,0.00001435764,0.00172617,0.9951504,0.00002407912,0.001806872,0.000008689623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732504,0.0004524987,0.02201746,0.00009443073,0.00008603856,0.0001251863,0.0004621706,0.0002995807,0.003212184],"genre_scores_gemma":[0.9696285,0.0002716134,0.02211277,0.0001593165,0.00002755369,0.0001154973,0.001026801,0.0001387148,0.006519351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003316036,"threshold_uncertainty_score":0.01109326,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}