{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":535,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":535,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"0eb5ace212dc","filters":{"topic":"Cholinesterase and Neurodegenerative Diseases"}},"results":[{"id":"W2805257646","doi":"10.1093/brain/awy132","title":"The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease","year":2018,"lang":"en","type":"review","venue":"Brain","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":1848,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Alzheimer Society; AXA Research Fund; Agence Nationale de la Recherche; National Research Council Sri Lanka","keywords":"Pathophysiology; Cholinergic; Cholinergic system; Neuroscience; Disease; Alzheimer's disease; Medicine; Psychology; Pathology","authors":[{"name":"Harald Hampel","is_ca":false},{"name":"M.‐Marsel Mesulam","is_ca":false},{"name":"A. Claudio Cuello","is_ca":true},{"name":"Martin R. Farlow","is_ca":false},{"name":"Ezio Giacobini","is_ca":false},{"name":"George T. Grossberg","is_ca":false},{"name":"Ara S. Khachaturian","is_ca":false},{"name":"Andrea Vergallo","is_ca":false},{"name":"Enrica Cavedo","is_ca":false},{"name":"Peter J. Snyder","is_ca":false},{"name":"Zaven S. Khachaturian","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08998758937444085,"gpt":0.374067354222015,"spread":0.2840797648475742,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007970819,0.0004508108,0.0008373161,0.001238903,0.000228909,0.0006784782,0.0006337714,0.001002075,0.002773443],"category_scores_gemma":[0.0007217953,0.0001129299,0.0005107253,0.0006827475,0.0003259112,0.0007821445,0.0004700399,0.001893138,0.001377648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005125045,"about_ca_system_score_gemma":0.0008286731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009789752,"about_ca_topic_score_gemma":0.001977146,"domain_scores_codex":[0.9996395,0.00009476949,0.00005867157,0.0000425267,0.0001349814,0.00002956681],"domain_scores_gemma":[0.9997802,0.00007765731,0.00003419241,0.000008035186,0.00007550752,0.0000243536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002465993,0.0001732946,0.0002644176,0.01204766,0.0001243331,0.0003701387,0.0001265932,0.0002979939,0.003942783,0.003801885,0.03431917,0.9442852],"study_design_scores_gemma":[0.00009989282,0.0005111627,0.002231296,0.0062402,0.0001983471,0.001624216,0.00008453926,0.0001541739,0.001391809,0.003777006,0.9836562,0.00003123017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003424276,0.9967005,0.0001491903,0.0007447795,0.0004211325,0.000008000486,0.00001946451,0.000009086381,0.001605501],"genre_scores_gemma":[0.002543072,0.9948525,0.0003509252,0.0004816939,0.000565487,0.000015692,0.00004205565,0.00000294797,0.001145645],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002773443,"threshold_uncertainty_score":0.009278059,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2111863354","doi":"10.1038/nrn1035","title":"Neurobiology of butyrylcholinesterase","year":2003,"lang":"en","type":"review","venue":"Nature reviews. Neuroscience","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":880,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Acetylcholine; Cholinergic; Serine hydrolase; Choline; Enzyme; Neuroscience; Cholinesterase; Nervous system; Chemistry; Neurotransmission; Biochemistry; Serine; Biology; Aché; Pharmacology; Receptor","authors":[{"name":"Sultan Darvesh","is_ca":true},{"name":"David A. Hopkins","is_ca":true},{"name":"Changiz Geula","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1230501289923292,"gpt":0.4578532292571864,"spread":0.3348031002648571,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008093038,0.001744027,0.002109038,0.002279561,0.0004222775,0.001659817,0.001668328,0.002247858,0.003130662],"category_scores_gemma":[0.0005928741,0.0004147812,0.0005247606,0.002429328,0.001187186,0.002773242,0.001036348,0.002760475,0.003919264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001245947,"about_ca_system_score_gemma":0.001547882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001871431,"about_ca_topic_score_gemma":0.003375513,"domain_scores_codex":[0.9998171,0.0000279599,0.00002768575,0.00003428085,0.0000720365,0.00002112755],"domain_scores_gemma":[0.9997221,0.00008956869,0.0000359162,0.00001393732,0.000102476,0.00003606183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001613465,0.00009416287,0.0002836815,0.01111527,0.0001006037,0.0006524335,0.00007582372,0.0004818622,0.005004688,0.007113175,0.07681003,0.8981068],"study_design_scores_gemma":[0.00002700484,0.00004301346,0.0005498238,0.001470872,0.0000593429,0.001493382,0.00004673758,0.00005742344,0.0005257765,0.003175534,0.9925328,0.00001809247],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005033375,0.9982017,0.0001396922,0.0002959269,0.0004035548,0.000002953948,0.00001000872,0.000005458346,0.0008902734],"genre_scores_gemma":[0.0003299907,0.9981774,0.0001589473,0.0002189028,0.0003389853,0.000005665563,0.00002246622,0.00000101306,0.0007466287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003130662,"threshold_uncertainty_score":0.01047313,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2155039139","doi":"10.1016/s1474-4422(03)00502-7","title":"Treatment of Alzheimer's disease; current status and new perspectives","year":2003,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":725,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"American Academy of Neurology; Pfizer","keywords":"Rivastigmine; Memantine; Galantamine; Donepezil; Medicine; Disease; Tacrine; Dementia; Alzheimer's disease; Pharmacology; Acetylcholinesterase; Bioinformatics; Internal medicine; Biology","authors":[{"name":"Elio Scarpini","is_ca":true},{"name":"Philip Schelterns","is_ca":true},{"name":"Howard Feldman","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08731596543438518,"gpt":0.3504418202794293,"spread":0.2631258548450441,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008353989,0.001399504,0.004917036,0.001522424,0.0008867313,0.00463587,0.002257165,0.00569258,0.01088641],"category_scores_gemma":[0.004647463,0.0004957523,0.00173479,0.00229684,0.003068003,0.007358009,0.001115085,0.007584301,0.002743401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001603732,"about_ca_system_score_gemma":0.00307483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002027438,"about_ca_topic_score_gemma":0.006837134,"domain_scores_codex":[0.9986144,0.0004119384,0.0002420414,0.0002102943,0.00035793,0.0001633375],"domain_scores_gemma":[0.9929301,0.004521251,0.0005914556,0.0001386813,0.001194563,0.000623952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006257371,0.0008955883,0.001383444,0.01228239,0.0005543607,0.0006711133,0.0002107486,0.0008877857,0.001993782,0.01062084,0.05948571,0.9047568],"study_design_scores_gemma":[0.003553316,0.004756562,0.005304505,0.008887572,0.001525561,0.001995732,0.00103336,0.001255338,0.0008564535,0.02464918,0.9460204,0.0001621015],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000589422,0.9843241,0.0003647494,0.01172113,0.001180002,0.00001000699,0.0000411095,0.00002269827,0.001746824],"genre_scores_gemma":[0.007667897,0.9755262,0.001252092,0.007564559,0.006643652,0.00005171299,0.0001104547,0.00001436007,0.001169062],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01088641,"threshold_uncertainty_score":0.04418069,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2154992193","doi":"10.1016/j.neubiorev.2011.03.001","title":"Revisiting the cholinergic hypothesis in the development of Alzheimer's disease","year":2011,"lang":"en","type":"review","venue":"Neuroscience & Biobehavioral Reviews","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":481,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary; University of Lethbridge","funders":"","keywords":"Cholinergic; Alzheimer's disease; Neuroscience; Disease; Psychology; Degenerative disease; Cholinergic neuron; Medicine; Central nervous system disease; Internal medicine","authors":[{"name":"Laura A. Craig","is_ca":true},{"name":"Nancy S. Hong","is_ca":true},{"name":"Robert J. McDonald","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.4057189359059125,"gpt":0.4376313169659748,"spread":0.03191238106006233,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001289274,0.001083266,0.001992947,0.002211686,0.0003749804,0.001407304,0.001396298,0.001940794,0.002482932],"category_scores_gemma":[0.0008998935,0.0003300272,0.0004611155,0.002284058,0.00101982,0.002655132,0.001079488,0.002746194,0.001502175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009438508,"about_ca_system_score_gemma":0.00187187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002526971,"about_ca_topic_score_gemma":0.005295027,"domain_scores_codex":[0.9997953,0.00004585303,0.00003584515,0.00002914593,0.00007264035,0.00002130067],"domain_scores_gemma":[0.9994876,0.0002573857,0.00006145649,0.00001581153,0.0001370922,0.00004048559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001614763,0.0001029585,0.0002674988,0.01757078,0.0001446501,0.0006488487,0.0001301718,0.0003768867,0.002501524,0.01079595,0.04051589,0.9267834],"study_design_scores_gemma":[0.00005590406,0.00009771466,0.001264832,0.005062263,0.0001599628,0.001884665,0.0001608296,0.0001227132,0.0004562411,0.007263747,0.9834422,0.00002886479],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005415005,0.999119,0.00004089094,0.0003519931,0.000132861,0.000001084374,0.000003541599,0.000001546993,0.0002950311],"genre_scores_gemma":[0.0003207581,0.9990196,0.00006811382,0.0001502576,0.0002152119,0.00000174381,0.000006054203,4.333382e-7,0.0002178418],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002526971,"threshold_uncertainty_score":0.008306205,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2903299905","doi":"10.14283/jpad.2018.43","title":"Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research","year":2019,"lang":"en","type":"review","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":355,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche sur Alzheimer; Canadian Institutes of Health Research; Alzheimer Society; Merck Canada; AXA Research Fund; Agence Nationale de la Recherche; Sorbonne Université","keywords":"Cholinergic; Neuroscience; Dementia; Disease; Rivastigmine; Cholinergic neuron; Neurodegeneration; Medicine; Alzheimer's disease; Cholinergic system; Pathogenesis; Donepezil; Psychology; Internal medicine","authors":[{"name":"Harald Hampel","is_ca":false},{"name":"M.‐Marsel Mesulam","is_ca":false},{"name":"A. Claudio Cuello","is_ca":true},{"name":"Ara S. Khachaturian","is_ca":false},{"name":"Andrea Vergallo","is_ca":false},{"name":"Martin R. Farlow","is_ca":false},{"name":"Peter J. Snyder","is_ca":false},{"name":"Ezio Giacobini","is_ca":false},{"name":"Zaven S. Khachaturian","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.4067319508572091,"gpt":0.5067138568799471,"spread":0.09998190602273793,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001929094,0.0009070893,0.002269777,0.003643223,0.0003251068,0.001645568,0.001241438,0.001708173,0.002791261],"category_scores_gemma":[0.002091847,0.0003174201,0.0008843641,0.003660808,0.0009917666,0.002733555,0.0009800942,0.002926984,0.0009062077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00108935,"about_ca_system_score_gemma":0.002751093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001564524,"about_ca_topic_score_gemma":0.003016604,"domain_scores_codex":[0.9995252,0.0001196312,0.00009089858,0.00006828556,0.0001587168,0.00003725226],"domain_scores_gemma":[0.9982734,0.001156819,0.0001672817,0.00003401734,0.000288491,0.0000799456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000149312,0.00006743279,0.0002568989,0.06464884,0.0002312433,0.0003280658,0.0001705255,0.0003134058,0.001009774,0.007269914,0.02666103,0.8988935],"study_design_scores_gemma":[0.00005210498,0.0002062652,0.001998698,0.03867401,0.0005935458,0.001869857,0.0003135203,0.0001503022,0.0002802875,0.008633421,0.9471896,0.00003830095],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002817307,0.9995207,0.00001797069,0.000197859,0.0000941396,0.000001044311,0.000002461897,0.00000115158,0.0001365419],"genre_scores_gemma":[0.0002302981,0.9993925,0.00003991053,0.0001491597,0.0001155084,0.000001449224,0.00000488985,2.980774e-7,0.00006596376],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003643223,"threshold_uncertainty_score":0.01020211,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2136873160","doi":"10.7326/0003-4819-148-5-200803040-00008","title":"Current Pharmacologic Treatment of Dementia: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians","year":2008,"lang":"en","type":"article","venue":"Annals of Internal Medicine","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":350,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Dementia; Guideline; Tolerability; Memantine; Mood; Quality of life (healthcare); Clinical trial; Donepezil; Intensive care medicine; MEDLINE; Alternative medicine; Adverse effect; Family medicine; Psychiatry; Disease; Internal medicine; Nursing","authors":[{"name":"Amir Qaseem","is_ca":false},{"name":"Vincenza Snow","is_ca":false},{"name":"J. Thomas Cross","is_ca":false},{"name":"Mary Ann Forciea","is_ca":false},{"name":"Robert Hopkins","is_ca":false},{"name":"Paul Shekelle","is_ca":false},{"name":"Alan Adelman","is_ca":false},{"name":"David R. Mehr","is_ca":false},{"name":"Kenneth G. Schellhase","is_ca":false},{"name":"Doug Campos‐Outcalt","is_ca":false},{"name":"Pasqualina Santaguida","is_ca":true},{"name":"Douglas K Owens","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1568127141389124,"gpt":0.4903783363833689,"spread":0.3335656222444565,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005682167,0.001248062,0.002120187,0.004064098,0.001222713,0.001228987,0.003872502,0.006465063,0.006354101],"category_scores_gemma":[0.01404704,0.0007106528,0.002868735,0.003150473,0.0007529129,0.001932195,0.001202044,0.007985758,0.005441543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003561265,"about_ca_system_score_gemma":0.01121272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02341577,"about_ca_topic_score_gemma":0.04996785,"domain_scores_codex":[0.9952426,0.001382454,0.00125215,0.0002102232,0.001676292,0.0002363548],"domain_scores_gemma":[0.988332,0.002342605,0.001349797,0.0001993102,0.007081304,0.0006949141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008406506,0.0002265793,0.0008406246,0.003614915,0.0001145671,0.0002921227,0.0001235735,0.0005206278,0.0003467471,0.001297285,0.8036133,0.1889256],"study_design_scores_gemma":[0.0009319636,0.0001949977,0.01148986,0.03488682,0.000574227,0.00133766,0.0002927713,0.001614991,0.0004720474,0.006408064,0.9416833,0.0001133181],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.005508864,0.2740221,0.05610182,0.456015,0.03119158,0.0204674,0.02071085,0.002066303,0.133916],"genre_scores_gemma":[0.02599604,0.3463051,0.3197118,0.1798097,0.01037322,0.02264197,0.03179979,0.0003305703,0.06303186],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02341577,"threshold_uncertainty_score":0.04655898,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2144075042","doi":"10.1517/14740338.2014.914168","title":"Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine","year":2014,"lang":"en","type":"review","venue":"Expert Opinion on Drug Safety","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":301,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institute of Health Economics","funders":"","keywords":"Rivastigmine; Donepezil; Galantamine; Medicine; Memantine; Clinical trial; Disease; Intensive care medicine; Alzheimer's disease; Dementia; Pharmacology; Psychiatry; Internal medicine","authors":[{"name":"Filip Zemek","is_ca":false},{"name":"Lucie Drtinová","is_ca":false},{"name":"Eugenie Nepovimová","is_ca":false},{"name":"Vendula Šepsová","is_ca":false},{"name":"Jan Korábečný","is_ca":false},{"name":"Jiřı́ Klimeš","is_ca":true},{"name":"Kamil Kuča","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05566749583418899,"gpt":0.3762010186461809,"spread":0.3205335228119919,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009336531,0.0006001287,0.001637247,0.0009455776,0.0001266124,0.0006228568,0.00064584,0.0008325505,0.004353945],"category_scores_gemma":[0.001590727,0.000114677,0.001061655,0.0008491587,0.0001732918,0.0005350508,0.0002985189,0.0007488368,0.0008843847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000470964,"about_ca_system_score_gemma":0.0007209181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006873711,"about_ca_topic_score_gemma":0.001332436,"domain_scores_codex":[0.9995919,0.0001039492,0.00009266647,0.00005396024,0.0001321548,0.00002536174],"domain_scores_gemma":[0.9994823,0.0002249337,0.0001445529,0.000008488365,0.0001199293,0.00001973499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0004107968,0.00005957768,0.000313455,0.05706051,0.0008000773,0.0001932778,0.00004213368,0.0002635822,0.001169792,0.001129679,0.01882115,0.919736],"study_design_scores_gemma":[0.0007398366,0.001402381,0.009718749,0.07417581,0.005248191,0.004865094,0.0002086835,0.0004643296,0.002523035,0.003366818,0.8972098,0.00007727927],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002480782,0.9986113,0.0000418782,0.0002251497,0.00009949741,0.000006203519,0.00003935745,0.000002346122,0.0007261393],"genre_scores_gemma":[0.003658277,0.9952645,0.0001387683,0.0002728808,0.0001672346,0.0000159058,0.00007813469,0.00000106068,0.0004032491],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004353945,"threshold_uncertainty_score":0.01456541,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2774623109","doi":"10.3390/molecules22122098","title":"Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":293,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Ministère des Armées; European Synchrotron Radiation Facility; Dalhousie Medical Research Foundation","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Chemistry; Decamethonium; Isothermal titration calorimetry; Ligand (biochemistry); Torpedo; Cholinergic; Stereochemistry; Rational design; Radioligand; Binding site; Hydrolase; Biophysics; Biochemistry; Enzyme; Acetylcholine receptor; Aché; Receptor; Biology; Neuroscience","authors":[{"name":"Terrone L. Rosenberry","is_ca":false},{"name":"Xavier Brazzolotto","is_ca":false},{"name":"Ian R. Macdonald","is_ca":true},{"name":"M. Wandhammer","is_ca":false},{"name":"M. Trovaslet-Leroy","is_ca":false},{"name":"Sultan Darvesh","is_ca":true},{"name":"Florian Nachon","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05080775021622023,"gpt":0.3736349437069566,"spread":0.3228271934907364,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002634731,0.0004167795,0.000523885,0.0002274429,0.000209066,0.0003281789,0.0006674003,0.0004309876,0.001041502],"category_scores_gemma":[0.0005404872,0.0002145354,0.0002808896,0.0003422476,0.0002493968,0.0002585716,0.000120421,0.0005557318,0.0001785849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008388179,"about_ca_system_score_gemma":0.0003655189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008989795,"about_ca_topic_score_gemma":0.006771855,"domain_scores_codex":[0.9997049,0.00004589438,0.00002105583,0.00004462313,0.0001385917,0.00004490994],"domain_scores_gemma":[0.9998066,0.00007924922,0.0000327336,0.00001233096,0.00004784915,0.00002131734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006570308,0.0003224812,0.003345276,0.0003017312,0.0001853011,0.0002399637,0.0001753986,0.006862902,0.9779567,0.0007030564,0.000623899,0.00862635],"study_design_scores_gemma":[0.00005317913,0.0003027149,0.007011371,0.00001125074,0.00007049069,0.0003289284,0.00006336366,0.01674289,0.9717805,0.00009340432,0.003515542,0.00002643948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884448,0.004992751,0.003307649,0.0002053603,0.00001993713,0.0000299432,0.0003212637,0.00005364198,0.002624697],"genre_scores_gemma":[0.9920071,0.002244309,0.002652405,0.00008127175,0.000009204444,0.00002420522,0.001227188,0.00001865711,0.001735512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008989795,"threshold_uncertainty_score":0.0178749,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2732879716","doi":"10.1007/s13238-017-0437-z","title":"Carboxylesterases in lipid metabolism: from mouse to human","year":2017,"lang":"en","type":"review","venue":"Protein & Cell","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":289,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; Lipid metabolism; Xenobiotic; Enzyme; Gene knockdown; Biochemistry; Metabolism; Metabolic pathway; Gene","authors":[{"name":"Jihong Lian","is_ca":true},{"name":"Randal C. Nelson","is_ca":true},{"name":"Richard Lehner","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1451803816377635,"gpt":0.4044258431930463,"spread":0.2592454615552828,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005842889,0.0007706966,0.0009408492,0.0019881,0.0001553888,0.0008652457,0.0007050131,0.0009492736,0.002941584],"category_scores_gemma":[0.0003440839,0.0002622333,0.0004023068,0.001487228,0.0005053337,0.001083425,0.0006121247,0.001525587,0.002914451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004254814,"about_ca_system_score_gemma":0.0007023404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006794992,"about_ca_topic_score_gemma":0.0008196715,"domain_scores_codex":[0.9998522,0.00002091854,0.0000239414,0.00003389254,0.00005291187,0.00001605378],"domain_scores_gemma":[0.9998591,0.00003659632,0.0000261411,0.0000077626,0.00004682384,0.00002361809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000227218,0.0000916879,0.0005072527,0.01257546,0.00008437112,0.0005125561,0.0001207177,0.0002356188,0.03096527,0.006388654,0.02489748,0.9233938],"study_design_scores_gemma":[0.00001579464,0.0001017919,0.0009280676,0.001155955,0.00009098381,0.00161996,0.00004040417,0.00004045453,0.003445992,0.00145076,0.9910923,0.00001758504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004460824,0.9965248,0.0004398997,0.0003160359,0.0001762676,0.00000614517,0.00006266364,0.00002538431,0.002002758],"genre_scores_gemma":[0.001696502,0.9954315,0.000623133,0.0002805231,0.0001184738,0.00001185719,0.0001163227,0.000006711992,0.001714838],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002941584,"threshold_uncertainty_score":0.009840548,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2144363852","doi":"","title":"Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":266,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Rivastigmine; Galantamine; Donepezil; Medicine; Placebo; Adverse effect; Internal medicine; Randomized controlled trial; Meta-analysis; Dementia; Confidence interval; Disease; Alternative medicine","authors":[{"name":"Krista L. Lanctôt","is_ca":true},{"name":"Kenneth K. Yau","is_ca":false},{"name":"Lyla R. Khan","is_ca":false},{"name":"Barbara A. Liu","is_ca":false},{"name":"Maysoon Loulou","is_ca":false},{"name":"Thomas R. Einarson","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08129242181646693,"gpt":0.3005125962015452,"spread":0.2192201743850783,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02167286,0.004026731,0.01930294,0.007787195,0.0006673107,0.003161605,0.002408599,0.002996474,0.003695493],"category_scores_gemma":[0.03760374,0.002235717,0.06136146,0.005837151,0.0006828399,0.001607246,0.001461475,0.002697028,0.0004294849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00213286,"about_ca_system_score_gemma":0.002051929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005786525,"about_ca_topic_score_gemma":0.007949639,"domain_scores_codex":[0.9808796,0.0121305,0.003185828,0.001868151,0.001529337,0.000406576],"domain_scores_gemma":[0.9800217,0.01452536,0.003137252,0.0008969718,0.001010168,0.0004085113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005172606,0.00002036009,0.004021319,0.02738466,0.9605463,0.00006936643,0.00002251921,0.0005719195,0.0001253642,0.00005006149,0.0002071891,0.001808424],"study_design_scores_gemma":[0.001401062,0.0002157173,0.00230017,0.001140246,0.9940401,0.00005263616,0.00001411519,0.0002538256,0.00008512088,0.0001174197,0.0003683104,0.00001129818],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03582615,0.955369,0.003348113,0.0005959279,0.0007650075,0.0008053418,0.002420014,0.0001345314,0.000735877],"genre_scores_gemma":[0.7444444,0.2411806,0.006923159,0.001118731,0.0006743952,0.002461052,0.002155865,0.0001128333,0.0009289704],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02167286,"threshold_uncertainty_score":0.1146184,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2943149722","doi":"10.1007/s12035-019-1605-3","title":"Cholinergic Differentiation of Human Neuroblastoma SH-SY5Y Cell Line and Its Potential Use as an In vitro Model for Alzheimer’s Disease Studies","year":2019,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":245,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"","keywords":"Choline acetyltransferase; Neurite; Cholinergic; Acetylcholinesterase; Cholinergic neuron; SH-SY5Y; Cell culture; Biology; Neuroblastoma; Cell biology; In vitro; Internal medicine; Neuroscience; Endocrinology; Medicine; Biochemistry; Enzyme","authors":[{"name":"Liana Marengo de Medeiros","is_ca":false},{"name":"Marco Antônio De Bastiani","is_ca":false},{"name":"Eduardo Pacheco Rico","is_ca":false},{"name":"Patrícia Schönhofen","is_ca":false},{"name":"Bianca Pfaffenseller","is_ca":true},{"name":"Bianca Wollenhaupt-Aguiar","is_ca":true},{"name":"Lucas Kich Grün","is_ca":false},{"name":"Florencia María Barbé‐Tuana","is_ca":false},{"name":"Eduardo R. Zimmer","is_ca":false},{"name":"Mauro A. A. Castro","is_ca":false},{"name":"Richard B. Parsons","is_ca":false},{"name":"Fábio Klamt","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04951309395966124,"gpt":0.3292259150422705,"spread":0.2797128210826093,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004098979,0.000333246,0.0004208205,0.0004614719,0.0005045906,0.0003528736,0.0003043758,0.0002882377,0.0009719071],"category_scores_gemma":[0.0001755294,0.0001422888,0.0004622212,0.0004059511,0.0002163957,0.000361063,0.0003135327,0.0008573213,0.0006444514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003348993,"about_ca_system_score_gemma":0.0004212234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004917977,"about_ca_topic_score_gemma":0.007121277,"domain_scores_codex":[0.999796,0.00002213574,0.00004843954,0.00003391288,0.00006562382,0.0000339523],"domain_scores_gemma":[0.9998629,0.00003204408,0.00001293743,0.00002771577,0.0000443752,0.00001994906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009046071,0.00004902763,0.00042848,0.00005405773,0.000007675203,0.0002033546,0.00009727302,0.00004514324,0.9970971,0.0002188971,0.00004768836,0.001660764],"study_design_scores_gemma":[0.00001063036,0.0002613513,0.005922271,0.00001585086,0.00005689255,0.0006025006,0.0001135792,0.0005764315,0.9877328,0.00009736358,0.004603733,0.000006622143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646243,0.008010472,0.01469473,0.0002175374,0.0001706083,0.000132641,0.001797122,0.000112212,0.01024041],"genre_scores_gemma":[0.9557209,0.008690773,0.01671277,0.00008501734,0.00004636657,0.0002062757,0.003717084,0.00004082212,0.01477997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004917977,"threshold_uncertainty_score":0.009778678,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2140719894","doi":"10.1185/030079905x56565","title":"Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period","year":2005,"lang":"en","type":"article","venue":"Current Medical Research and Opinion","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":230,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Novartis Pharma; Novartis","keywords":"Rivastigmine; Donepezil; Tolerability; Medicine; Adverse effect; Discontinuation; Cholinesterase; Internal medicine; Dementia; Population; Randomized controlled trial; Disease","authors":[{"name":"Roger Bullock","is_ca":false},{"name":"Jacques Touchon","is_ca":false},{"name":"Howard Bergman","is_ca":true},{"name":"Giuseppe Gambina","is_ca":false},{"name":"Yunsheng He","is_ca":false},{"name":"Günter Rapatz","is_ca":false},{"name":"Jennifer Nagel","is_ca":false},{"name":"Roger Lane","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1425517985465833,"gpt":0.4508608017460685,"spread":0.3083090031994851,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0030969,0.000673515,0.003241158,0.0005071387,0.0002907216,0.0005859025,0.0006239712,0.001177244,0.001792195],"category_scores_gemma":[0.003354247,0.0003786341,0.002109093,0.0005301784,0.0005521886,0.0006325075,0.0004094984,0.0009798229,0.0002631613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007549648,"about_ca_system_score_gemma":0.0008749074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007645845,"about_ca_topic_score_gemma":0.001760664,"domain_scores_codex":[0.9975128,0.001380127,0.0003402277,0.0003448076,0.0002156876,0.0002062698],"domain_scores_gemma":[0.9984249,0.000375827,0.0006964749,0.0001085698,0.00007956386,0.0003147241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9395527,0.00825487,0.003778848,0.001699926,0.002727746,0.00007833674,0.00008922624,0.0002756756,0.002709303,0.00005768818,0.0004876419,0.04028819],"study_design_scores_gemma":[0.7324785,0.2249003,0.03902769,0.0001353252,0.001354601,0.0001187622,0.00003395074,0.0003005946,0.0006661339,0.0001081948,0.0008509423,0.00002498977],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851135,0.01194472,0.0002431955,0.0001877662,0.0002376276,0.001029281,0.0003213544,0.00003035594,0.0008922861],"genre_scores_gemma":[0.9940174,0.003006646,0.0004368944,0.0003089262,0.0002259049,0.001074836,0.0003875091,0.000003358262,0.0005386391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003241158,"threshold_uncertainty_score":0.0163781,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4213301132","doi":"10.3390/antiox11020408","title":"Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation","year":2022,"lang":"en","type":"review","venue":"Antioxidants","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":227,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; U.S. Department of Defense","keywords":"Oxidative stress; Antioxidant; Neurodegeneration; Reactive oxygen species; Reactive nitrogen species; Chemistry; Pharmacology; Biochemistry; Oxidative phosphorylation; Medicine; Pathology","authors":[{"name":"Anushruti Ashok","is_ca":false},{"name":"Syed Suhail Andrabi","is_ca":false},{"name":"Saffar Mansoor","is_ca":false},{"name":"Youzhi Kuang","is_ca":false},{"name":"Brian K. Kwon","is_ca":true},{"name":"Vinod Labhasetwar","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1061014793230243,"gpt":0.3764076686496348,"spread":0.2703061893266104,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002626271,0.0006014555,0.001129716,0.001018376,0.0002463947,0.001585282,0.0006840742,0.002086053,0.003156863],"category_scores_gemma":[0.002028567,0.0002676096,0.0007411354,0.00062709,0.0008642009,0.002075054,0.0008367283,0.003197326,0.001054778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009098822,"about_ca_system_score_gemma":0.001240342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008352821,"about_ca_topic_score_gemma":0.00101961,"domain_scores_codex":[0.9995534,0.0001385449,0.00003906334,0.0000824712,0.0001375771,0.00004890583],"domain_scores_gemma":[0.9989549,0.0005061372,0.0001285788,0.00003608353,0.0002755586,0.00009864863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006649513,0.0009235655,0.0004335295,0.009539829,0.0001346811,0.000531929,0.0003034178,0.001197277,0.04469646,0.01352041,0.01987615,0.9081777],"study_design_scores_gemma":[0.0005869162,0.007005875,0.002711207,0.005687762,0.0003501423,0.002138091,0.0002955193,0.003419376,0.03888973,0.01291892,0.9258553,0.0001411017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005117537,0.9792883,0.005943629,0.005395835,0.0008015811,0.00009932479,0.00007047738,0.00008549326,0.003197786],"genre_scores_gemma":[0.04590907,0.9375988,0.008858953,0.003796373,0.0009342119,0.0002661023,0.0001961031,0.00004486689,0.002395577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003156863,"threshold_uncertainty_score":0.01388919,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2107857520","doi":"10.1517/14728222.11.2.161","title":"Targeting acetylcholinesterase to treat neurodegeneration","year":2007,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":213,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba","funders":"","keywords":"Acetylcholinesterase; Acetylcholine; Cholinergic; Neurodegeneration; Pharmacology; Alzheimer's disease; Disease; Medicine; Neuroscience; Aché; Cholinesterase; Muscarinic acetylcholine receptor; Chemistry; Internal medicine; Biology; Biochemistry; Enzyme; Receptor","authors":[{"name":"Ulrike Holzgrabe","is_ca":false},{"name":"Petra Kapková","is_ca":true},{"name":"Vildan Alptüzün","is_ca":false},{"name":"Josef Scheiber","is_ca":false},{"name":"Eva Kugelmann","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1564226520126159,"gpt":0.4447747027527863,"spread":0.2883520507401705,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003868492,0.0009581965,0.001312631,0.001479858,0.0002158397,0.0005261284,0.0007780627,0.001092643,0.005036343],"category_scores_gemma":[0.0001715846,0.0001837206,0.0003402936,0.0009707323,0.0003177432,0.0006451849,0.0004297833,0.00130799,0.004651437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004703951,"about_ca_system_score_gemma":0.0004999702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008700171,"about_ca_topic_score_gemma":0.001674686,"domain_scores_codex":[0.9998924,0.00001628768,0.000008363822,0.00001832627,0.00005028157,0.00001443518],"domain_scores_gemma":[0.9999449,0.00001356899,0.00001029452,0.000002415583,0.000019955,0.000008966451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001287242,0.0002574103,0.000121415,0.009214997,0.000117572,0.000807677,0.00008823799,0.0006544536,0.03247524,0.004318622,0.03200149,0.9198141],"study_design_scores_gemma":[0.0001047536,0.0003725463,0.0007775223,0.001464542,0.0001079135,0.00264036,0.00005692103,0.000285812,0.00533454,0.002179588,0.9866545,0.0000209048],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001002875,0.9910057,0.00114992,0.0005366409,0.0004502346,0.0000339821,0.00003223155,0.00003886815,0.005749465],"genre_scores_gemma":[0.003353887,0.990783,0.001129412,0.0005441183,0.000221512,0.00003742334,0.00007966327,0.000005120023,0.003845836],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005036343,"threshold_uncertainty_score":0.01684827,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2315120195","doi":"10.2174/1567205013666160404120542","title":"Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease","year":2016,"lang":"en","type":"review","venue":"Current Alzheimer Research","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":209,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Veterans Affairs Canada","funders":"Canadian Institutes of Health Research","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Neuroscience; Cholinergic; Dementia; Neurotransmitter; Acetylcholine; Alzheimer's disease; Cholinesterase; Psychology; Medicine; Aché; Disease; Internal medicine; Chemistry; Central nervous system; Enzyme; Biochemistry","authors":[{"name":"Sultan Darvesh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3932117321800884,"gpt":0.5374206331975706,"spread":0.1442089010174822,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004101492,0.0004460801,0.0003966385,0.0003874553,0.0001710521,0.0004844289,0.0002880773,0.0007837113,0.001250264],"category_scores_gemma":[0.0002348654,0.0001417721,0.0002797937,0.0002483608,0.0003831188,0.0003773968,0.0002500124,0.001085669,0.0004967293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004045806,"about_ca_system_score_gemma":0.0003966871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005680329,"about_ca_topic_score_gemma":0.001025854,"domain_scores_codex":[0.999842,0.00003813002,0.0000105569,0.00002892571,0.00005647819,0.00002382295],"domain_scores_gemma":[0.9999044,0.00001782399,0.00002150816,0.000008949514,0.00002607003,0.00002127159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007173548,0.0003566834,0.001329332,0.001018337,0.00008475167,0.0007405985,0.00009215073,0.0006853663,0.8382311,0.003061444,0.003357649,0.1503253],"study_design_scores_gemma":[0.0003608429,0.005046399,0.007372661,0.0003340276,0.0004602311,0.006355177,0.0001125374,0.002935958,0.7858595,0.002514144,0.188576,0.00007250385],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2327257,0.7184532,0.0251186,0.00689049,0.001193345,0.0002408981,0.0003686583,0.0003451727,0.01466383],"genre_scores_gemma":[0.7014039,0.2646407,0.01964629,0.002441072,0.000526373,0.0001382947,0.0005910212,0.00003891139,0.0105735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001250264,"threshold_uncertainty_score":0.004182577,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2056978169","doi":"10.1016/s0166-4328(00)00261-8","title":"Alzheimer's disease: more than a ‘cholinergic disorder' — evidence that cholinergic–monoaminergic interactions contribute to EEG slowing and dementia","year":2000,"lang":"en","type":"review","venue":"Behavioural Brain Research","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroscience; Monoaminergic; Cholinergic; Basal forebrain; Cholinergic neuron; Psychology; Neocortex; Electroencephalography; Hippocampus; Dementia; Serotonergic; Alzheimer's disease; Medicine; Disease; Internal medicine; Serotonin","authors":[{"name":"Hans C. Dringenberg","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2994947097351768,"gpt":0.4867319691332481,"spread":0.1872372593980713,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004965142,0.0009939626,0.002296529,0.002264014,0.000238925,0.0008313999,0.0008786902,0.001156724,0.003255277],"category_scores_gemma":[0.0008068359,0.0002431955,0.0003404616,0.002906832,0.0004348804,0.001462065,0.0005610863,0.001109275,0.001811125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004880197,"about_ca_system_score_gemma":0.001068815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002317023,"about_ca_topic_score_gemma":0.005511035,"domain_scores_codex":[0.999838,0.00002172439,0.00003845458,0.00003161505,0.00005884429,0.00001125387],"domain_scores_gemma":[0.9996678,0.0001334458,0.00006686229,0.00001141142,0.00008427667,0.00003622745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001631669,0.00006761296,0.0003298571,0.01074468,0.0001239224,0.0003904434,0.00004339577,0.0001368483,0.001230376,0.0007164686,0.0266066,0.9594467],"study_design_scores_gemma":[0.00009574562,0.0001692045,0.004874594,0.004950151,0.0004326623,0.00401193,0.0001450188,0.000100996,0.0004680078,0.001746816,0.9829701,0.00003483374],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001189066,0.9987029,0.00008372476,0.0002312037,0.0002398111,0.000003704164,0.00001455525,0.000005621917,0.0005995726],"genre_scores_gemma":[0.0006377734,0.9980434,0.0001917564,0.0002575223,0.0003062292,0.000004913745,0.00002723928,9.236325e-7,0.0005302524],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003255277,"threshold_uncertainty_score":0.01089001,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2155842706","doi":"10.1007/s00335-010-9284-4","title":"Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins","year":2010,"lang":"en","type":"article","venue":"Mammalian Genome","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; National Institute of Environmental Health Sciences; American Lebanese Syrian Associated Charities; National Human Genome Research Institute; St. Jude Children's Research Hospital","keywords":"Pseudogene; Biology; Gene nomenclature; Gene; Carboxylesterase; Gene family; Genetics; Human genome; Genome; Nomenclature; Enzyme; Biochemistry","authors":[{"name":"Roger S. Holmes","is_ca":false},{"name":"Matt W. Wright","is_ca":false},{"name":"Stanley J. F. Laulederkind","is_ca":false},{"name":"Laura A. Cox","is_ca":false},{"name":"Masakiyo Hosokawa","is_ca":false},{"name":"Teruko Imai","is_ca":false},{"name":"Shun Ishibashi","is_ca":false},{"name":"Richard Lehner","is_ca":true},{"name":"Masao Miyazaki","is_ca":false},{"name":"E.J. Perkins","is_ca":false},{"name":"Philip M. Potter","is_ca":false},{"name":"Matthew R. Redinbo","is_ca":false},{"name":"Jacques Robert","is_ca":false},{"name":"Tetsuo Satoh","is_ca":false},{"name":"Tetsuro Yamashita","is_ca":false},{"name":"Bingfan Yan","is_ca":false},{"name":"Tsuyoshi Yokoi","is_ca":false},{"name":"Rudolf Zechner","is_ca":false},{"name":"Lois J. Maltais","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01897266823805388,"gpt":0.2742852158007585,"spread":0.2553125475627047,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001404339,0.002790599,0.002340328,0.004778804,0.002079194,0.001567668,0.003504672,0.002380994,0.03290836],"category_scores_gemma":[0.005113845,0.0008148914,0.001715515,0.006183512,0.001645971,0.00175645,0.001056575,0.005729902,0.03262156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001390604,"about_ca_system_score_gemma":0.003959919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003847296,"about_ca_topic_score_gemma":0.006156787,"domain_scores_codex":[0.9983491,0.0005206959,0.0004035878,0.0002740527,0.0002925997,0.0001599452],"domain_scores_gemma":[0.9943948,0.001233894,0.000712442,0.000595325,0.002588224,0.0004753504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001234743,0.0002316244,0.001630092,0.00356136,0.00009019349,0.001218804,0.0005304096,0.001172842,0.05553995,0.02785438,0.6807449,0.2261908],"study_design_scores_gemma":[0.0001080028,0.0002165641,0.003253976,0.0006829948,0.00008907656,0.002168045,0.0002547844,0.0004736316,0.007103757,0.005296345,0.9802985,0.00005430309],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03270179,0.08799536,0.4497827,0.04480793,0.09136368,0.005760939,0.09349091,0.01510951,0.1789871],"genre_scores_gemma":[0.03077077,0.02992308,0.7363307,0.01430384,0.002907469,0.006735686,0.09581305,0.002814635,0.08040076],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.03290836,"threshold_uncertainty_score":0.1100894,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4220993307","doi":"10.1093/brain/awac096","title":"Reimagining cholinergic therapy for Alzheimer’s disease","year":2022,"lang":"en","type":"review","venue":"Brain","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":174,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Basal forebrain; Cholinergic; Cholinergic neuron; Neuroscience; Memantine; Alzheimer's disease; Donepezil; Disease; Medicine; Acetylcholinesterase; Psychology; Dementia; Internal medicine; Biology","authors":[{"name":"Ezio Giacobini","is_ca":false},{"name":"Abraham Fisher","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2628301668772831,"gpt":0.4476347435420774,"spread":0.1848045766647944,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004195547,0.0004240365,0.000630937,0.0009060364,0.0001412715,0.000624392,0.0005283122,0.0007047078,0.004508913],"category_scores_gemma":[0.000393503,0.00009431483,0.0004944071,0.0004605159,0.0002583643,0.0007059039,0.0004460045,0.001459375,0.001512262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565761,"about_ca_system_score_gemma":0.0004321138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004461017,"about_ca_topic_score_gemma":0.001277451,"domain_scores_codex":[0.9998047,0.00004358007,0.0000332301,0.000024106,0.00007567128,0.00001874522],"domain_scores_gemma":[0.9998834,0.00003943868,0.00002470826,0.000005164144,0.0000344179,0.00001280761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003458323,0.0001900831,0.0002345374,0.01321331,0.0001642563,0.000838275,0.000171234,0.0002076933,0.02111871,0.005104397,0.02724177,0.93117],"study_design_scores_gemma":[0.00009994863,0.0004652642,0.001307144,0.002310364,0.0001831488,0.002526031,0.00006612032,0.0001380065,0.003667738,0.002380497,0.9868356,0.00002022503],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001445414,0.9930747,0.0003966506,0.0006741324,0.0007964072,0.00001739598,0.00004546193,0.00002272293,0.003527167],"genre_scores_gemma":[0.009699577,0.9811709,0.001158923,0.0009923064,0.001113542,0.00003246087,0.000184105,0.0000116407,0.005636569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004508913,"threshold_uncertainty_score":0.01508379,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W20646326","doi":"10.1016/j.aquatox.2003.11.004","title":"Acetylcholinesterase inhibition as a biomarker of adverse effect","year":2004,"lang":"en","type":"article","venue":"Aquatic Toxicology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan; Global Institute for Water Security","funders":"Plymouth University; Department for Environment, Food and Rural Affairs, UK Government","keywords":"Acetylcholinesterase; Hemolymph; Aché; Mytilus; Neurotoxicity; Neutral red; Toxicology; Pharmacology; Cytotoxicity; Organophosphate; Biomarker; Chemistry; Toxicity; Biology; Pesticide; Biochemistry; Enzyme; In vitro; Ecology","authors":[{"name":"Carrie J. Rickwood","is_ca":true},{"name":"Tamara S. Galloway","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02112872185870506,"gpt":0.3203347384557469,"spread":0.2992060165970418,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006527213,0.0005133711,0.0003958406,0.001432118,0.0004450576,0.0005585433,0.0002779947,0.0007639629,0.001229541],"category_scores_gemma":[0.0009709941,0.0001923958,0.0002743819,0.0007175489,0.0005891207,0.0003532553,0.0003293103,0.0007388164,0.0002457827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003240964,"about_ca_system_score_gemma":0.0005132733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002321987,"about_ca_topic_score_gemma":0.003499891,"domain_scores_codex":[0.9995779,0.000117853,0.00004233907,0.00005350323,0.0001678684,0.0000404701],"domain_scores_gemma":[0.9991054,0.0001935396,0.0003267064,0.00004408769,0.0002087,0.0001216431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003784385,0.0006431678,0.3541639,0.000348647,0.0003239907,0.001019391,0.0004414549,0.0004975416,0.6165131,0.0004505159,0.0004392018,0.02137477],"study_design_scores_gemma":[0.00005998716,0.007966384,0.5508571,0.00006205755,0.0004244781,0.002970298,0.0007748755,0.00238703,0.4307567,0.0005826778,0.003118867,0.00003956671],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867982,0.004221461,0.002965488,0.0001373149,0.00007358564,0.00006485357,0.000475031,0.00006789379,0.005196025],"genre_scores_gemma":[0.994758,0.001148948,0.001744603,0.00008678707,0.00002498786,0.00004966288,0.0001988898,0.000004729481,0.001983488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002321987,"threshold_uncertainty_score":0.004616916,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2024623973","doi":"10.1097/00002093-200304000-00011","title":"Inhibition of Human Cholinesterases by Drugs Used to Treat Alzheimer Disease","year":2003,"lang":"en","type":"article","venue":"Alzheimer Disease & Associated Disorders","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of New Brunswick; Mount Saint Vincent University; Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Cholinesterase; Galantamine; Physostigmine; Donepezil; Rivastigmine; Pharmacology; Aché; Acetylcholine; Alzheimer's disease; Tacrine; Chemistry; Biochemistry; Internal medicine; Enzyme; Medicine; Disease; Dementia","authors":[{"name":"Sultan Darvesh","is_ca":true},{"name":"Ryan Walsh","is_ca":false},{"name":"Rohit Kumar","is_ca":true},{"name":"Angela Caines","is_ca":true},{"name":"Sheila Roberts","is_ca":true},{"name":"David I. MaGee","is_ca":true},{"name":"Kenneth Rockwood","is_ca":false},{"name":"Earl Martin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03172525753105169,"gpt":0.3087539808753446,"spread":0.2770287233442929,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004704117,0.0007637853,0.0008865243,0.0005165802,0.0001902206,0.0003949849,0.0003189307,0.0004372206,0.002437262],"category_scores_gemma":[0.0003479654,0.0002235014,0.0003222785,0.000566143,0.0003035395,0.0003603481,0.0002812959,0.0006352394,0.0009592021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004370064,"about_ca_system_score_gemma":0.0004041475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121721,"about_ca_topic_score_gemma":0.002221187,"domain_scores_codex":[0.9996086,0.0001119544,0.00004734585,0.00004650641,0.0001231568,0.00006247913],"domain_scores_gemma":[0.9998714,0.00002718078,0.00003728536,0.00001813539,0.00002917271,0.00001679495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009235272,0.0003074002,0.0006429143,0.0006745319,0.00009173611,0.0001641069,0.00006489227,0.0001198374,0.9573004,0.0002946148,0.0005097571,0.03890629],"study_design_scores_gemma":[0.0002009679,0.003386294,0.003461755,0.00007791328,0.0001282863,0.0009405175,0.00003691974,0.0002072173,0.9697456,0.00009003936,0.02171246,0.00001204201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6508794,0.3252699,0.00806829,0.0006200152,0.0004496113,0.0004619686,0.0006621788,0.0002740921,0.01331448],"genre_scores_gemma":[0.8074988,0.1720404,0.009558468,0.0003465992,0.0001773559,0.000254549,0.001167857,0.00004015078,0.008915906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002437262,"threshold_uncertainty_score":0.008153439,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2072688677","doi":"10.1021/jm8002075","title":"Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Chemistry; Acetylcholinesterase; Stereochemistry; Phenothiazine; Moiety; Cholinesterase; Catalytic triad; Active site; Enzyme; Biochemistry; Pharmacology; Aché","authors":[{"name":"Sultan Darvesh","is_ca":true},{"name":"Katherine Valenta Darvesh","is_ca":true},{"name":"Robert McDonald","is_ca":true},{"name":"Diane Mataija","is_ca":true},{"name":"Ryan Walsh","is_ca":true},{"name":"Sam Mothana","is_ca":true},{"name":"Oksana Lockridge","is_ca":true},{"name":"Earl Martin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02115056036294405,"gpt":0.2535483030634773,"spread":0.2323977427005332,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002040616,0.0003801265,0.0004174545,0.0002483717,0.00009100203,0.0003037421,0.0003801052,0.0003800981,0.0007244632],"category_scores_gemma":[0.0002401061,0.0001712646,0.0002975471,0.0002207326,0.0002286839,0.0003248915,0.0002044773,0.0004697648,0.000223072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002116511,"about_ca_system_score_gemma":0.000117404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004481148,"about_ca_topic_score_gemma":0.0005693291,"domain_scores_codex":[0.9997774,0.00003643809,0.00002544119,0.00003331035,0.00006153659,0.0000659689],"domain_scores_gemma":[0.9998469,0.00003273121,0.0000352674,0.00002444633,0.00002711997,0.00003341194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003422439,0.00005426368,0.000186481,0.0000737858,0.00002016455,0.0001118702,0.00001610778,0.0001172787,0.9945855,0.0002701666,0.00004093886,0.004181235],"study_design_scores_gemma":[0.00006704504,0.00138735,0.002190472,0.000004863595,0.00003081782,0.0006437723,0.00001178707,0.0004910226,0.9938105,0.00006109668,0.001294721,0.000006550634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861019,0.008019695,0.0025861,0.00006776809,0.00003589822,0.00005602345,0.0001716896,0.0000930528,0.0028679],"genre_scores_gemma":[0.9954435,0.001697868,0.001341378,0.00004281172,0.00001062105,0.00002896038,0.0001909463,0.00001155819,0.001232378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007244632,"threshold_uncertainty_score":0.002423584,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1981945499","doi":"10.1097/nen.0b013e31823cc7a6","title":"Butyrylcholinesterase Is Associated With β-Amyloid Plaques in the Transgenic APP<sub>SWE</sub>/PSEN1dE9 Mouse Model of Alzheimer Disease","year":2011,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Butyrylcholinesterase; Thioflavin; Immunostaining; Pathology; Alzheimer's disease; Genetically modified mouse; Acetylcholinesterase; Senile plaques; Amyloid (mycology); Immunohistochemistry; Biology; Transgene; Aché; Medicine; Disease; Biochemistry; Enzyme","authors":[{"name":"Sultan Darvesh","is_ca":true},{"name":"Meghan K. Cash","is_ca":true},{"name":"G. Andrew Reid","is_ca":true},{"name":"Earl Martin","is_ca":true},{"name":"Arnold Mitnitski","is_ca":true},{"name":"Changiz Geula","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05557986016765855,"gpt":0.2884073281358777,"spread":0.2328274679682191,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003228767,0.00141348,0.0008658461,0.001726318,0.0005814559,0.0006764779,0.0003503341,0.001263405,0.001970478],"category_scores_gemma":[0.0002119138,0.000694942,0.0007466403,0.0006115767,0.0005390288,0.000722752,0.0004385494,0.001758265,0.0009000259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941185,"about_ca_system_score_gemma":0.0002441844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093024,"about_ca_topic_score_gemma":0.001546071,"domain_scores_codex":[0.999605,0.00003563345,0.00006256292,0.000119706,0.0001142556,0.00006284654],"domain_scores_gemma":[0.9995595,0.00003176515,0.0001691306,0.00003959678,0.00005099833,0.0001491215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003515213,0.0001526773,0.0003983114,0.00005404779,0.00002310922,0.0004692645,0.00006179701,0.00003015779,0.9975538,0.00009664232,0.00006225634,0.0007464605],"study_design_scores_gemma":[0.0003079181,0.002604659,0.07244404,0.00008801815,0.0002871766,0.008511615,0.0002262781,0.00203858,0.9060922,0.0009307024,0.006407358,0.00006130785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918704,0.002270161,0.002744841,0.0002784375,0.00007465554,0.00008632504,0.0009205348,0.0001964073,0.001558299],"genre_scores_gemma":[0.9759511,0.00404887,0.005912772,0.000258554,0.00007078768,0.000263238,0.002367586,0.0001876486,0.01093962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001970478,"threshold_uncertainty_score":0.006591856,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2160272501","doi":"10.1002/hep.25961","title":"Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia","year":2012,"lang":"en","type":"article","venue":"Hepatology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; European Commission; Heart and Stroke Foundation of Canada","keywords":"Lipogenesis; Internal medicine; Endocrinology; Steatosis; Hyperlipidemia; Fatty liver; Sterol regulatory element-binding protein; Apolipoprotein B; Polyunsaturated fatty acid; Chemistry; Nonalcoholic fatty liver disease; Hyperinsulinemia; Insulin resistance; Biology; Lipid metabolism; Cholesterol; Fatty acid; Obesity; Medicine; Diabetes mellitus; Biochemistry; Sterol","authors":[{"name":"Ariel D. Quiroga","is_ca":true},{"name":"Lena Li","is_ca":true},{"name":"Martin Trötzmüller","is_ca":false},{"name":"Randy Nelson","is_ca":true},{"name":"Spencer D. Proctor","is_ca":true},{"name":"Harald Köfeler","is_ca":false},{"name":"Richard Lehner","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03054180023056029,"gpt":0.3022843258948075,"spread":0.2717425256642472,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167777,0.001054727,0.0003105655,0.0003850178,0.0001624412,0.0002926091,0.0002838379,0.0004148109,0.003202294],"category_scores_gemma":[0.0001440893,0.0001887159,0.0001829434,0.0002780644,0.0005853876,0.0001951387,0.0003637246,0.0003645605,0.0007061444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344352,"about_ca_system_score_gemma":0.0001768283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002414608,"about_ca_topic_score_gemma":0.0002793696,"domain_scores_codex":[0.9998569,0.00002531964,0.00002687103,0.0000371633,0.00003068885,0.00002315447],"domain_scores_gemma":[0.9997469,0.0000340557,0.0001339292,0.00001615431,0.00001279668,0.00005621114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001243644,0.00005930832,0.003685111,0.0001988344,0.00004050181,0.0003570751,0.00001904062,0.00007243077,0.9889309,0.0001593844,0.0001343027,0.005099433],"study_design_scores_gemma":[0.0001360056,0.0005257807,0.03339139,0.00004515254,0.0001384484,0.003946732,0.00007183469,0.0004478605,0.9563754,0.0001852147,0.004725321,0.00001094358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990046,0.005149864,0.002641473,0.0002638692,0.00004183187,0.00002450551,0.000567795,0.0001836542,0.001081141],"genre_scores_gemma":[0.9884964,0.004149309,0.002493241,0.00008983003,0.00002139339,0.00004355454,0.0008329294,0.00004588223,0.003827421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003202294,"threshold_uncertainty_score":0.01071274,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2006152123","doi":"10.1016/j.neuroscience.2015.04.039","title":"Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model","year":2015,"lang":"en","type":"article","venue":"Neuroscience","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie Medical Research Foundation","keywords":"Neuroscience; Butyrylcholinesterase; Amyloid (mycology); Knockout mouse; Alzheimer's disease; Amyloid β; Chemistry; Biology; Pathology; Medicine; Aché; Biochemistry; Acetylcholinesterase; Disease; Receptor; Enzyme","authors":[{"name":"G. Andrew Reid","is_ca":true},{"name":"Sultan Darvesh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1268715758938134,"gpt":0.3664611447164502,"spread":0.2395895688226369,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005099759,0.00183186,0.0008310328,0.002090326,0.0005790507,0.0008329949,0.000842259,0.001366355,0.002611884],"category_scores_gemma":[0.0002982546,0.000664931,0.0007069046,0.0005473895,0.0008486402,0.0008385062,0.000451293,0.001937847,0.0007412664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006334423,"about_ca_system_score_gemma":0.000457756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002066361,"about_ca_topic_score_gemma":0.002897535,"domain_scores_codex":[0.9994598,0.00007309386,0.00009029279,0.0001225803,0.0001199926,0.0001342539],"domain_scores_gemma":[0.9992709,0.00006173596,0.0002927244,0.00006367635,0.00008288797,0.0002281493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007917976,0.0002206506,0.0001701619,0.00005659556,0.00003872534,0.0001511231,0.00003881533,0.00005573333,0.9975209,0.0001810034,0.00009287475,0.0006815728],"study_design_scores_gemma":[0.0001459808,0.0005130597,0.003624976,0.00003030153,0.0001901241,0.0004768702,0.0001062747,0.000905966,0.9920928,0.000321078,0.001574877,0.00001767039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903881,0.002099936,0.00407023,0.00045006,0.0001424334,0.00006993047,0.0009081791,0.0003438841,0.001527265],"genre_scores_gemma":[0.9785821,0.002753452,0.005977138,0.0002258891,0.00005182633,0.0001825374,0.001091014,0.0002269533,0.01090912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002611884,"threshold_uncertainty_score":0.008737624,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1990854180","doi":"10.1002/cne.10751","title":"Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus","year":2003,"lang":"en","type":"article","venue":"The Journal of Comparative Neurology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Thalamus; Biology; Acetylcholine; Neuroscience; Cholinergic; Cholinesterase; Aché; Central nervous system; Internal medicine; Endocrinology; Enzyme; Medicine; Biochemistry","authors":[{"name":"Sultan Darvesh","is_ca":true},{"name":"David A. Hopkins","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0491037705598984,"gpt":0.3411022978692582,"spread":0.2919985273093598,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123475,0.0002145366,0.0002351719,0.000919202,0.00008041301,0.0004867376,0.0001319847,0.0001404781,0.001965774],"category_scores_gemma":[0.0003427761,0.0001540613,0.0001801233,0.0005222433,0.0002159373,0.0002071285,0.0002540333,0.0001055564,0.0003821544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002169468,"about_ca_system_score_gemma":0.000147159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002562762,"about_ca_topic_score_gemma":0.002980663,"domain_scores_codex":[0.9999008,0.00001524282,0.00001047293,0.00002466871,0.00002961903,0.0000191919],"domain_scores_gemma":[0.9999211,0.00001460589,0.00002137803,0.000006946713,0.00002208933,0.00001391722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009673703,0.00003177883,0.06885908,0.0004772572,0.0002061199,0.006172588,0.002113285,0.0002070466,0.8661746,0.0008966636,0.0003796724,0.05351447],"study_design_scores_gemma":[0.000107142,0.001231303,0.8067228,0.000212535,0.0002991065,0.0482037,0.002895148,0.002133218,0.126225,0.001544766,0.01035553,0.00006981289],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757219,0.01113483,0.006124424,0.00006988713,0.00001631577,0.00004756675,0.0006323674,0.00007821086,0.006174625],"genre_scores_gemma":[0.9941058,0.002829516,0.001449371,0.00003378882,0.000006265773,0.00001998438,0.0003682183,0.00001827153,0.001168831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562762,"threshold_uncertainty_score":0.006576121,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2008784533","doi":"10.1074/jbc.m412644200","title":"A Family of Acetylcholine-gated Chloride Channel Subunits in Caenorhabditis elegans","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true},"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Caenorhabditis elegans; Acetylcholine; Chloride channel; Chemistry; Cell biology; Biology; Genetics; Pharmacology; Gene","authors":[{"name":"Igor Putrenko","is_ca":true},{"name":"Mahvash Zakikhani","is_ca":true},{"name":"Joseph A. Dent","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04528520476233981,"gpt":0.2911180165853379,"spread":0.2458328118229981,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004828947,0.0003802001,0.0001338517,0.0003268481,0.0004722812,0.0002480437,0.0002322528,0.000253174,0.0007524635],"category_scores_gemma":[0.0001272272,0.0001361282,0.000169161,0.0001539468,0.0001528811,0.0001816421,0.0001967486,0.0002798015,0.0004773476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002888264,"about_ca_system_score_gemma":0.0004185923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006089631,"about_ca_topic_score_gemma":0.007521448,"domain_scores_codex":[0.9999284,0.000002337564,0.000004974866,0.00002642853,0.00002920861,0.000008607872],"domain_scores_gemma":[0.9999309,0.000004317721,0.00001757684,0.000006186903,0.00002087698,0.00002029097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009746847,0.00001498923,0.002296275,0.0001390355,0.00001115859,0.0005017556,0.00003922022,0.0002127568,0.9854813,0.000242502,0.0006319659,0.01033152],"study_design_scores_gemma":[0.0001821758,0.0008546241,0.3249807,0.0002469678,0.0002006538,0.007955409,0.0003576683,0.00745852,0.5294793,0.001336106,0.1268252,0.0001226958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597214,0.008202862,0.0135477,0.0002679639,0.0002412274,0.0002033994,0.006010452,0.001195603,0.01060951],"genre_scores_gemma":[0.9640819,0.004193625,0.01660178,0.0001695607,0.00002219285,0.000159237,0.005280159,0.00003587248,0.009455687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006089631,"threshold_uncertainty_score":0.01210839,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2056604025","doi":"10.2174/1567205054367829","title":"An Overview of Phenserine Tartrate, A Novel Acetylcholinesterase Inhibitor for the Treatment of Alzheimers Disease","year":2005,"lang":"en","type":"review","venue":"Current Alzheimer Research","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Active Ethernet Passive Optical Networks Over λ MultipleXing (Canada)","funders":"Division of Chemistry","keywords":"Physostigmine; Acetylcholinesterase inhibitor; Cholinesterase; Acetylcholinesterase; Tolerability; Donepezil; Acetylcholine; Pharmacology; Alzheimer's disease; Cholinergic; Galantamine; Amyloid beta; Medicine; Amyloid precursor protein; Neuroscience; Internal medicine; Chemistry; Disease; Psychology; Dementia; Adverse effect; Biochemistry; Enzyme","authors":[{"name":"Nigel H. Greig","is_ca":false},{"name":"Kumar Sambamurti","is_ca":false},{"name":"Qian-sheng Yu","is_ca":false},{"name":"Arnold Brossi","is_ca":false},{"name":"Gosse Bruinsma","is_ca":true},{"name":"Debomoy K. Lahiri","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.7206795462904803,"gpt":0.6014282851800552,"spread":0.1192512611104251,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003595724,0.0008776945,0.0007651468,0.001994084,0.0002621386,0.0007221372,0.0006273261,0.0009138585,0.003517625],"category_scores_gemma":[0.0002732729,0.0002333807,0.000586345,0.00117015,0.0001766801,0.001003071,0.0003060533,0.001736096,0.002197481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003901824,"about_ca_system_score_gemma":0.0005296945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008712598,"about_ca_topic_score_gemma":0.002039689,"domain_scores_codex":[0.9998598,0.00002831822,0.00002205076,0.00002757542,0.00004314992,0.0000190362],"domain_scores_gemma":[0.9998902,0.00003111388,0.00002031419,0.000003912246,0.00003375361,0.00002073027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004785986,0.0005464636,0.0003973295,0.008783987,0.0001562596,0.0006297077,0.0000963819,0.0005894616,0.02000191,0.003857742,0.05125478,0.9132073],"study_design_scores_gemma":[0.0001022551,0.001191064,0.001969062,0.0009108174,0.0001687539,0.002816634,0.00003725027,0.0003341782,0.002325088,0.00100187,0.989117,0.00002617876],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002044596,0.9875697,0.001135095,0.0009515773,0.0006298852,0.00007452924,0.0001769646,0.00006746506,0.007350162],"genre_scores_gemma":[0.005255948,0.984629,0.002192443,0.001071716,0.0007784722,0.00008852321,0.0004427393,0.00001193076,0.005529213],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003517625,"threshold_uncertainty_score":0.01176763,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2136022643","doi":"10.1002/anie.200800522","title":"Total Synthesis of (+)‐Fawcettidine","year":2008,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Annulation; Chemistry; Key (lock); Stereochemistry; Computer science; Organic chemistry; Catalysis","authors":[{"name":"Jennifer A. Kozak","is_ca":true},{"name":"Gregory R. Dake","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02762392807860221,"gpt":0.2817879050333476,"spread":0.2541639769547454,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285835,0.0004665058,0.0003647571,0.0002652068,0.0002298735,0.0002193678,0.0004773942,0.0003275615,0.003300442],"category_scores_gemma":[0.0001528913,0.0001370365,0.0002564667,0.000289047,0.0001260998,0.0004205702,0.0004326651,0.0004605233,0.001625215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003192048,"about_ca_system_score_gemma":0.0004594631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005724374,"about_ca_topic_score_gemma":0.001204356,"domain_scores_codex":[0.9998956,0.000009071957,0.00001191577,0.000024605,0.0000284039,0.00003047991],"domain_scores_gemma":[0.9999477,0.000005946595,0.000009255691,0.00001033506,0.00001194368,0.00001480263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001064975,0.00003630938,0.0001023972,0.0003822826,0.00002833598,0.0004036252,0.0001236907,0.0005127539,0.9715006,0.001929378,0.000433116,0.024441],"study_design_scores_gemma":[0.00003511381,0.0003543847,0.0006853996,0.00001768571,0.00002915814,0.0004937932,0.00001606061,0.0005377457,0.9752741,0.000324796,0.02221377,0.00001792451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8565421,0.006929235,0.07154308,0.0003419218,0.0002909832,0.0006064893,0.00307401,0.0009467551,0.05972554],"genre_scores_gemma":[0.9552476,0.003722298,0.02479292,0.0000959438,0.00002561356,0.0001911717,0.001049455,0.00009223587,0.01478269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003300442,"threshold_uncertainty_score":0.01104105,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2045800802","doi":"10.1016/j.cca.2006.11.005","title":"A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India","year":2006,"lang":"en","type":"article","venue":"Clinica Chimica Acta","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Health Sciences Centre","funders":"","keywords":"Butyrylcholinesterase; Ghrelin; Internal medicine; Medicine; Acetylcholinesterase; Endocrinology; Creatine kinase; Toxicity; Adverse effect; Cholinesterase; Physiology; Aché; Biology; Hormone; Biochemistry; Enzyme","authors":[{"name":"Indumathi Manoharan","is_ca":false},{"name":"Rathnam Boopathy","is_ca":false},{"name":"Sultan Darvesh","is_ca":true},{"name":"Oksana Lockridge","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04630046921354568,"gpt":0.370593275037544,"spread":0.3242928058239983,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760535,0.0003351817,0.0002508369,0.001340217,0.002329304,0.0006415105,0.0005175533,0.001117384,0.002537343],"category_scores_gemma":[0.0009585398,0.0002486029,0.0002944362,0.001305867,0.0006999146,0.0003833101,0.0007805043,0.001028221,0.0002880569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006206409,"about_ca_system_score_gemma":0.00112628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07173632,"about_ca_topic_score_gemma":0.04201503,"domain_scores_codex":[0.9996176,0.00007244841,0.00004209788,0.00005187856,0.00005866267,0.0001573885],"domain_scores_gemma":[0.9991136,0.0001939074,0.000174949,0.00003995228,0.0001789718,0.0002985517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001295833,0.0002698202,0.9213508,0.00007080138,0.00003707033,0.06606054,0.00609561,0.00004838056,0.001916894,0.0002137921,0.00148273,0.002323932],"study_design_scores_gemma":[0.00001853526,0.0004308864,0.9498752,0.00003486223,0.00006279643,0.0318681,0.01517473,0.0001389479,0.0003168294,0.0001087242,0.001935834,0.0000345752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926842,0.0002145607,0.00008900568,0.001252369,0.00005311945,0.000049235,0.0006213773,0.0000134568,0.005022723],"genre_scores_gemma":[0.9981539,0.0002079863,0.00007413419,0.000607592,0.00004593611,0.000009905876,0.0001597528,0.000002510064,0.000738177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07173632,"threshold_uncertainty_score":0.1426376,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2948322960","doi":"10.1016/j.trci.2019.03.004","title":"The role of acetylcholinesterase inhibitors such as neostigmine and rivastigmine on chronic pain and cognitive function in aging: A review of recent clinical applications","year":2019,"lang":"en","type":"review","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Rivastigmine; Neostigmine; Dementia; Chronic pain; Medicine; Acetylcholinesterase; Alzheimer's disease; Analgesic; Disease; Cognition; Anesthesia; Physical therapy; Donepezil; Psychiatry; Internal medicine","authors":[{"name":"Jabril Eldufani","is_ca":true},{"name":"Gilbert Blaise","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.359679253345677,"gpt":0.5591606113691664,"spread":0.1994813580234894,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006557497,0.0007764672,0.00173802,0.00285998,0.0002554785,0.0008801616,0.0008004629,0.0009262352,0.004380032],"category_scores_gemma":[0.0009981318,0.0002820959,0.001014123,0.002620773,0.0003016844,0.001095339,0.0005635316,0.001182294,0.001049836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004356291,"about_ca_system_score_gemma":0.001157627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198244,"about_ca_topic_score_gemma":0.002401955,"domain_scores_codex":[0.9998117,0.00003614105,0.00004615538,0.00003416558,0.00005732871,0.00001457378],"domain_scores_gemma":[0.9994879,0.0003224251,0.0000723358,0.000009760342,0.0000858466,0.0000217231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.000156762,0.00009797078,0.0001862619,0.0731424,0.0002280538,0.0002143674,0.0001106362,0.0003182054,0.001293602,0.001662881,0.01342727,0.9091615],"study_design_scores_gemma":[0.00007940862,0.0004421284,0.00225489,0.03110691,0.001081931,0.002172363,0.000175231,0.0001812998,0.0007329715,0.001926074,0.9598005,0.00004618918],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008274559,0.9994618,0.00003029112,0.0000808029,0.00004960876,0.000003559103,0.00001206891,0.000002423134,0.0002766076],"genre_scores_gemma":[0.0003670914,0.9992761,0.00007120807,0.00007369435,0.00004443387,0.000005105863,0.00001465006,6.008136e-7,0.0001470472],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004380032,"threshold_uncertainty_score":0.01465261,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1978130969","doi":"10.2165/00002512-200118110-00006","title":"Cholinergic Adverse Effects of Cholinesterase Inhibitors in Alzheimer??s Disease","year":2001,"lang":"en","type":"review","venue":"Drugs & Aging","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Adverse effect; Donepezil; Acetylcholinesterase; Galantamine; Rivastigmine; Cholinesterase; Cholinergic; Alzheimer's disease; Clinical trial; Disease; Pharmacology; Internal medicine; Dementia","authors":[{"name":"Serge Gauthier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03275454582207475,"gpt":0.3469148485294261,"spread":0.3141603027073513,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006960768,0.0008912308,0.002339489,0.002047615,0.0002398944,0.0007129867,0.000800487,0.001098286,0.003297615],"category_scores_gemma":[0.0008648934,0.0002338086,0.0006406881,0.002106212,0.0002636342,0.0007442768,0.0003688083,0.000828745,0.001192204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003895093,"about_ca_system_score_gemma":0.0006614837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002032305,"about_ca_topic_score_gemma":0.005433338,"domain_scores_codex":[0.9997864,0.00003935201,0.00004795298,0.00002848353,0.00008499969,0.00001283797],"domain_scores_gemma":[0.9995092,0.0002286703,0.0001220464,0.00001282293,0.00009849829,0.00002868682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003151963,0.000118459,0.0004589567,0.01556006,0.0003135204,0.0006009182,0.00003972861,0.0002591681,0.001650542,0.0005067755,0.01355291,0.9666238],"study_design_scores_gemma":[0.0003679667,0.0009353113,0.009306774,0.008105624,0.002248931,0.008277613,0.0001270916,0.0002942425,0.001958873,0.001444127,0.966871,0.00006230347],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002954928,0.9985606,0.00008949271,0.0001313786,0.00008148349,0.000005014423,0.00002045503,0.000006072303,0.0008099733],"genre_scores_gemma":[0.001361795,0.9975598,0.0001794328,0.0001670123,0.00013416,0.000005112351,0.00002609064,8.900707e-7,0.0005657575],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003297615,"threshold_uncertainty_score":0.01103169,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2030018752","doi":"10.1016/j.clinbiochem.2005.04.008","title":"Relationship between serum butyrylcholinesterase and the metabolic syndrome","year":2005,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"St. John’s Health Sciences Centre; Memorial University of Newfoundland","funders":"","keywords":"Internal medicine; Metabolic syndrome; Endocrinology; Insulin resistance; Triglyceride; Medicine; Butyrylcholinesterase; Abdominal obesity; Obesity; Population; Diabetes mellitus; Biology; Cholesterol; Enzyme; Biochemistry","authors":[{"name":"Edward Randell","is_ca":true},{"name":"Maria S. Mathews","is_ca":true},{"name":"Hongwei Zhang","is_ca":true},{"name":"Jim S. Seraj","is_ca":true},{"name":"Guang Sun","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07202154437111069,"gpt":0.385080707240779,"spread":0.3130591628696683,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007173667,0.0005118501,0.0006222296,0.001403093,0.0004208802,0.0006283562,0.0003139272,0.001117485,0.00206213],"category_scores_gemma":[0.004971375,0.0004144291,0.0004741523,0.001336744,0.0005840565,0.0005630932,0.0002848814,0.001768074,0.0002373848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939406,"about_ca_system_score_gemma":0.0005111013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002175345,"about_ca_topic_score_gemma":0.001601689,"domain_scores_codex":[0.9995178,0.0002259078,0.00006434173,0.00006492861,0.00007827278,0.00004877144],"domain_scores_gemma":[0.9957047,0.002107523,0.0009499738,0.0002552073,0.0003808148,0.0006018346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009201791,0.00007811331,0.995089,0.00001194719,0.0001601666,0.0007470879,0.0000211958,0.00009193365,0.0009525929,0.00008539902,0.00007447982,0.001767877],"study_design_scores_gemma":[0.00002754383,0.0002810489,0.995561,0.000006373178,0.0001041363,0.002775431,0.0000554628,0.0005526103,0.0002899313,0.000201458,0.0001375772,0.000007368963],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934464,0.003236527,0.0004616217,0.0005076967,0.00005430921,0.00001175514,0.0002037354,0.00002574862,0.002052111],"genre_scores_gemma":[0.9989248,0.0003972455,0.0001931749,0.00007364667,0.00005825797,0.000005051729,0.00009950718,0.000002378421,0.0002459219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002175345,"threshold_uncertainty_score":0.006898522,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2048167422","doi":"10.1016/j.arr.2011.01.003","title":"Revisiting the cholinergic hypothesis of behavioral and psychological symptoms in dementia of the Alzheimer's type","year":2011,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of New Brunswick; University of Toronto; Sunnybrook Health Science Centre; Canada Research Chairs; Health Sciences Centre","funders":"Canadian Institutes of Health Research","keywords":"Apathy; Irritability; Dementia; Disinhibition; Psychology; Anxiety; Psychosis; Psychiatry; Depression (economics); Personality changes; Alzheimer's disease; Clinical psychology; Medicine; Disease; Personality; Internal medicine; Cognition","authors":[{"name":"T Bismarck Pinto","is_ca":true},{"name":"Krista L. Lanctôt","is_ca":true},{"name":"Nathan Herrmann","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.5200208055376033,"gpt":0.5098377568208529,"spread":0.01018304871675046,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001204116,0.001183058,0.002956636,0.002851248,0.0002833301,0.001305223,0.001213785,0.001698021,0.002286592],"category_scores_gemma":[0.001054648,0.000355566,0.0006634949,0.002905603,0.0008514597,0.002345235,0.000993501,0.002635336,0.001098881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007038584,"about_ca_system_score_gemma":0.001510462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002626999,"about_ca_topic_score_gemma":0.005442136,"domain_scores_codex":[0.9997783,0.00004595684,0.00004815322,0.00003415343,0.0000747435,0.00001863418],"domain_scores_gemma":[0.9992707,0.0004452209,0.00008697202,0.00001547292,0.0001422965,0.00003924262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001824923,0.00009838722,0.0003153334,0.0294906,0.0002667353,0.0004338826,0.0001056127,0.0002271913,0.001416812,0.003611174,0.02403438,0.9398174],"study_design_scores_gemma":[0.000137059,0.0002319961,0.004073158,0.01367012,0.0006864258,0.003642318,0.0003240064,0.0002110816,0.000531168,0.006305725,0.9701228,0.00006410309],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004367858,0.9995878,0.00002248831,0.0001456687,0.00007525148,8.442502e-7,0.000003209488,8.282787e-7,0.0001203052],"genre_scores_gemma":[0.0002818205,0.9992679,0.00005545608,0.0001143754,0.0001566938,0.000001496162,0.000007685189,3.384841e-7,0.0001141583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002956636,"threshold_uncertainty_score":0.007649362,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2054637070","doi":"10.1016/j.jalz.2011.11.005","title":"Benefits of combined cholinesterase inhibitor and memantine treatment in moderate–severe Alzheimer's disease","year":2012,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Center for Diagnosis and Research on Alzheimer's Disease","funders":"H. Lundbeck A/S","keywords":"Memantine; Donepezil; Cholinesterase; Combination therapy; Medicine; Rivastigmine; Pharmacology; Acetylcholinesterase; Alzheimer's disease; Internal medicine; Dementia; Disease; Biology","authors":[{"name":"Serge Gauthier","is_ca":true},{"name":"José Luís Molinuevo","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0896778210447526,"gpt":0.3363744418999209,"spread":0.2466966208551683,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009547389,0.0007783949,0.002631673,0.002153027,0.0001765954,0.0006664565,0.0008020679,0.001032708,0.00244143],"category_scores_gemma":[0.001521673,0.0002689432,0.001095286,0.001991235,0.0002170344,0.000540088,0.0003502868,0.0004980364,0.0003945946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004284951,"about_ca_system_score_gemma":0.0009541938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009641176,"about_ca_topic_score_gemma":0.002607316,"domain_scores_codex":[0.9995524,0.0001499829,0.0001098595,0.00005761384,0.0001078945,0.00002229135],"domain_scores_gemma":[0.9993931,0.000385731,0.0001317922,0.000008274972,0.00006008673,0.00002107903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006841965,0.0001047226,0.000457835,0.2654543,0.002255129,0.0004222344,0.00008839163,0.0002216785,0.001352631,0.000549751,0.00572428,0.7226849],"study_design_scores_gemma":[0.001809161,0.003020919,0.02383624,0.338321,0.03103079,0.0138736,0.0007345403,0.0005361419,0.003536772,0.002960065,0.580213,0.0001276383],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002567584,0.9994346,0.00001569529,0.0000352664,0.00002712363,0.000005284996,0.00001012702,0.000001431341,0.00021373],"genre_scores_gemma":[0.003429783,0.996192,0.0001303084,0.00007893184,0.00004023662,0.00001412243,0.00001813098,5.678637e-7,0.00009602692],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002631673,"threshold_uncertainty_score":0.008167446,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2141339944","doi":"10.1517/14740338.3.5.425","title":"The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer’s disease","year":2004,"lang":"en","type":"review","venue":"Expert Opinion on Drug Safety","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Galantamine; Medicine; Rivastigmine; Donepezil; Adverse effect; Cholinesterase; Dementia; Memantine; Disease; Pharmacology; Drug; Internal medicine; Intensive care medicine","authors":[{"name":"Sarah Thompson","is_ca":true},{"name":"Krista L. Lanctôt","is_ca":true},{"name":"Nathan Herrmann","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1180668148422715,"gpt":0.3888932999723099,"spread":0.2708264851300385,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0080374,0.0006117591,0.002078438,0.0009154266,0.0006001561,0.001856522,0.0005547598,0.001736093,0.004318221],"category_scores_gemma":[0.02295039,0.0003124746,0.002843413,0.0009719534,0.0009528011,0.00135976,0.0009584744,0.002888617,0.0004047274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001107208,"about_ca_system_score_gemma":0.001086463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354957,"about_ca_topic_score_gemma":0.003297904,"domain_scores_codex":[0.9926801,0.004471168,0.0008337583,0.0003172531,0.001510512,0.0001871906],"domain_scores_gemma":[0.9818497,0.0135123,0.002803512,0.0003075248,0.0009899368,0.0005370288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02337903,0.0005987909,0.03850592,0.03322332,0.01467238,0.00189324,0.0006490071,0.001297273,0.001949371,0.009703134,0.0159045,0.858224],"study_design_scores_gemma":[0.01404208,0.01885574,0.4798822,0.04993872,0.06960239,0.01686263,0.002599572,0.004404582,0.003269872,0.1158129,0.2240273,0.0007020934],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03299753,0.9444895,0.0004585318,0.01376876,0.0006263374,0.00003431152,0.0002805749,0.0000108519,0.007333679],"genre_scores_gemma":[0.4533421,0.5315956,0.001478875,0.006032988,0.005268307,0.00009374672,0.0002604588,0.00001216853,0.001915747],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0080374,"threshold_uncertainty_score":0.04250634,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2085475081","doi":"10.1177/1756285609102724","title":"Review: Therapy for Alzheimer's disease: how effective are current treatments?","year":2009,"lang":"en","type":"article","venue":"Therapeutic Advances in Neurological Disorders","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Memantine; Medicine; Tolerability; Disease; Rivastigmine; Alzheimer's disease; Cholinesterase; Neurotransmitter receptor; Intensive care medicine; Pharmacology; Donepezil; Internal medicine; Dementia; Receptor; Adverse effect","authors":[{"name":"Krista L. Lanctôt","is_ca":true},{"name":"Ryan D. Rajaram","is_ca":true},{"name":"Nathan Herrmann","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03884627347654957,"gpt":0.3714684075139778,"spread":0.3326221340374282,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00207456,0.001306683,0.006086178,0.002325607,0.00046047,0.001791533,0.001462996,0.003103371,0.006632613],"category_scores_gemma":[0.009975703,0.0003484988,0.001666213,0.004063446,0.000794194,0.002167893,0.0005120853,0.001653955,0.001576671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001464277,"about_ca_system_score_gemma":0.002601965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003511524,"about_ca_topic_score_gemma":0.008317316,"domain_scores_codex":[0.9988142,0.0005470401,0.0002336581,0.00008881874,0.0002776768,0.00003863159],"domain_scores_gemma":[0.9967169,0.002172137,0.0004691293,0.00004278249,0.0004789396,0.000120086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0007312793,0.00004585945,0.0003527369,0.3144816,0.002665188,0.0002474672,0.0001016015,0.0003888484,0.0003365861,0.001437323,0.1375601,0.5416515],"study_design_scores_gemma":[0.0007923151,0.0004026664,0.004824827,0.3710738,0.01551727,0.001370542,0.0004391794,0.0002958799,0.000345301,0.00544594,0.5994148,0.00007739172],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005969391,0.9977354,0.0000443547,0.001299307,0.0005358015,0.00001624229,0.00003717513,0.000003938724,0.000268118],"genre_scores_gemma":[0.001221213,0.9964557,0.0001455345,0.001467115,0.0004470943,0.00002582518,0.00003093338,0.000001781543,0.0002048714],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006632613,"threshold_uncertainty_score":0.02218837,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2912352250","doi":"10.3389/fnins.2019.00062","title":"The Brain NGF Metabolic Pathway in Health and in Alzheimer’s Pathology","year":2019,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Merck Canada; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Basal forebrain; Cholinergic; Cholinergic neuron; Neuroscience; Cognitive decline; Nerve growth factor; Entorhinal cortex; Astrogliosis; Alzheimer's disease; Dementia; Hippocampus; Internal medicine; Endocrinology; Medicine; Psychology; Disease; Central nervous system; Receptor","authors":[{"name":"A. Claudio Cuello","is_ca":true},{"name":"Rowan Pentz","is_ca":true},{"name":"Hélène Hall","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09626312556561203,"gpt":0.3779311552259321,"spread":0.2816680296603201,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003631773,0.0003740259,0.000343731,0.0005822603,0.000284022,0.0008269338,0.0002834839,0.0008404432,0.001124469],"category_scores_gemma":[0.00022852,0.00008677211,0.0001950174,0.0002711127,0.001082877,0.0009112734,0.0005270008,0.0006796722,0.0002377323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001086,"about_ca_system_score_gemma":0.0007092695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002394213,"about_ca_topic_score_gemma":0.002688074,"domain_scores_codex":[0.9999,0.00002232508,0.000005736235,0.00001861714,0.00002130266,0.00003198979],"domain_scores_gemma":[0.9999059,0.00001998726,0.00002348076,0.00000518293,0.00001735952,0.00002797332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003596714,0.0004900348,0.03119832,0.005279982,0.0002428158,0.006751686,0.00193474,0.002305251,0.1722562,0.1156064,0.0221343,0.6382035],"study_design_scores_gemma":[0.0001964944,0.001965638,0.3009107,0.003561794,0.0003419365,0.01234524,0.00503202,0.003031744,0.05304563,0.264524,0.3548222,0.0002225639],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1011217,0.8778939,0.001499052,0.009580796,0.0005269502,0.00001212765,0.0001624619,0.00003792128,0.009165174],"genre_scores_gemma":[0.4837856,0.5076963,0.001498412,0.0009647635,0.0006803598,0.00003389192,0.0001319061,0.000007053407,0.005201577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002394213,"threshold_uncertainty_score":0.007879496,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1996705438","doi":"10.1016/j.neurobiolaging.2013.04.026","title":"Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase","year":2013,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia Hospital","funders":"Ministry of Education, Science and Technology","keywords":"Choline acetyltransferase; Neurotrophin; Nerve growth factor; Neurotrophic factors; Cholinergic neuron; Neural stem cell; Cholinergic; Acetylcholine; Neuroscience; Brain-derived neurotrophic factor; Transplantation; Biology; Stem cell; Endocrinology; Internal medicine; Cell biology; Medicine; Biochemistry","authors":[{"name":"Dongsun Park","is_ca":false},{"name":"Yun‐Hui Yang","is_ca":false},{"name":"Dae Kwon Bae","is_ca":false},{"name":"Sun Hee Lee","is_ca":false},{"name":"Goeun Yang","is_ca":false},{"name":"Jangbeen Kyung","is_ca":false},{"name":"Dajeong Kim","is_ca":false},{"name":"Ehn‐Kyoung Choi","is_ca":false},{"name":"Seong Won Lee","is_ca":false},{"name":"Gonhyung Kim","is_ca":false},{"name":"Jin Tae Hong","is_ca":false},{"name":"Kyung‐Chul Choi","is_ca":false},{"name":"Hong Jun Lee","is_ca":false},{"name":"Seung Up Kim","is_ca":true},{"name":"Yun-Bae Kim","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01875903104492209,"gpt":0.2826568643811914,"spread":0.2638978333362693,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002503891,0.0007152986,0.0004902385,0.0007084088,0.0001702311,0.0003417025,0.0003403677,0.0005472898,0.001727401],"category_scores_gemma":[0.0001499091,0.0002335695,0.0005848611,0.0002751366,0.0005074663,0.0003221114,0.0002297554,0.001298249,0.0003681345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859939,"about_ca_system_score_gemma":0.0004636839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001752056,"about_ca_topic_score_gemma":0.001787694,"domain_scores_codex":[0.9998234,0.00001655569,0.0000252684,0.0000422195,0.00003545254,0.00005715704],"domain_scores_gemma":[0.9997957,0.00001810911,0.00005390911,0.00002477156,0.00002198017,0.00008564967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001057134,0.0002937954,0.0003814508,0.00003634168,0.00002933112,0.00008720678,0.00003998516,0.0001014338,0.9944618,0.0001279362,0.0001228296,0.003260772],"study_design_scores_gemma":[0.00028228,0.001988937,0.009521187,0.00001549508,0.000155231,0.0002295756,0.0001159148,0.001642458,0.9830687,0.0002051029,0.002754498,0.00002051891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954118,0.001047451,0.001696295,0.000209424,0.00009829463,0.00002840957,0.0006434726,0.0001349784,0.0007298516],"genre_scores_gemma":[0.9886043,0.0012197,0.001504166,0.0001559541,0.00003022814,0.0001086026,0.00126497,0.00004743248,0.007064706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752056,"threshold_uncertainty_score":0.00577873,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2891960083","doi":"10.1021/acssensors.8b00697","title":"Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and<i>In Vivo</i>Imaging","year":2018,"lang":"en","type":"article","venue":"ACS Sensors","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"Central China Normal University; Natural Science Foundation of Hubei Province; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Zebrafish; In vivo; Chemistry; Cell biology; Biochemistry; Enzyme; Biology; Aché; Biotechnology","authors":[{"name":"Shiyu Liu","is_ca":false},{"name":"Hao Xiong","is_ca":false},{"name":"Jiaqian Yang","is_ca":false},{"name":"Shu-Hou Yang","is_ca":false},{"name":"Yingfu Li","is_ca":true},{"name":"Wen‐Chao Yang","is_ca":false},{"name":"Guang‐Fu Yang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01840495545410028,"gpt":0.27681313585255,"spread":0.2584081803984498,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004662975,0.0004822842,0.0002550021,0.0002104372,0.0001733373,0.0002984412,0.0006425058,0.001046794,0.000554333],"category_scores_gemma":[0.0002805839,0.0002251223,0.0003640106,0.0001403603,0.000363999,0.0005410701,0.0003691122,0.0007162733,0.0003117108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004145945,"about_ca_system_score_gemma":0.0002569746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003605141,"about_ca_topic_score_gemma":0.0004647259,"domain_scores_codex":[0.9998497,0.0000333989,0.000006527122,0.00003689047,0.00003808953,0.00003530427],"domain_scores_gemma":[0.9998884,0.0000240934,0.00002805268,0.00001281298,0.00002571224,0.0000209088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002245747,0.00001659714,0.0000384906,0.00004232533,0.000004057197,0.00005938407,0.00001954133,0.0001743359,0.9960025,0.0007062498,0.00008637522,0.002827712],"study_design_scores_gemma":[0.000005250763,0.0001031511,0.0001202874,0.000003373717,0.000005805892,0.0001196747,0.000007305759,0.001107991,0.996445,0.00008384187,0.001991815,0.000006525512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6629817,0.009624474,0.3162882,0.001373206,0.0002344151,0.0003335845,0.0002705709,0.0005462389,0.008347644],"genre_scores_gemma":[0.8529171,0.004767631,0.1368362,0.0005419674,0.00004066508,0.0002519248,0.0002552909,0.00005028075,0.004338947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046794,"threshold_uncertainty_score":0.003008127,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2074919962","doi":"10.1016/j.tox.2006.11.069","title":"Sensitivity of butyrylcholinesterase knockout mice to (−)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission","year":2006,"lang":"en","type":"article","venue":"Toxicology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"National Cancer Institute; Medical Research and Materiel Command; Canadian Institutes of Health Research; Research Nova Scotia; Nova Scotia Health Research Foundation","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Aché; Cholinesterase; Huperzine A; Chemistry; Acetylcholine; Pharmacology; Internal medicine; Endocrinology; Biochemistry; Enzyme; Biology; Medicine","authors":[{"name":"Ellen G. Duysen","is_ca":false},{"name":"Bin Li","is_ca":false},{"name":"Sultan Darvesh","is_ca":true},{"name":"Oksana Lockridge","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01844025276950472,"gpt":0.2782709276379492,"spread":0.2598306748684445,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003848079,0.001312306,0.0005755896,0.001658978,0.0003173287,0.0006716061,0.0007630446,0.001169813,0.005679758],"category_scores_gemma":[0.0004292791,0.0005341959,0.0006357972,0.0002746973,0.001278121,0.0008254243,0.0004921765,0.001754899,0.001112268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000392336,"about_ca_system_score_gemma":0.0003778934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539102,"about_ca_topic_score_gemma":0.002046326,"domain_scores_codex":[0.999499,0.00004935008,0.00007225642,0.0001964823,0.0001021396,0.0000808715],"domain_scores_gemma":[0.9985744,0.0002696302,0.0005462577,0.0001902191,0.00008301168,0.0003365441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002862179,0.00006576768,0.000414443,0.00004041552,0.00003357996,0.0003146338,0.00003785331,0.00005616772,0.9972203,0.000351482,0.00010863,0.001070521],"study_design_scores_gemma":[0.0000564872,0.0005574871,0.00719898,0.00002078036,0.00007754927,0.002373306,0.00007403622,0.000415748,0.9865243,0.0005579747,0.002125105,0.00001831578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766132,0.001307225,0.01176723,0.0007567552,0.0002143278,0.0001150855,0.003475108,0.0008840748,0.004867023],"genre_scores_gemma":[0.9743669,0.001155138,0.009163814,0.00043387,0.00003624777,0.0001690744,0.002158397,0.0002796667,0.01223684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005679758,"threshold_uncertainty_score":0.01900065,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2091134922","doi":"10.1016/j.neuroscience.2012.12.054","title":"Butyrylcholinesterase and the cholinergic system","year":2013,"lang":"en","type":"article","venue":"Neuroscience","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Choline acetyltransferase; Butyrylcholinesterase; Acetylcholine; Cholinergic; Neuropil; Acetylcholinesterase; Neuroscience; Cholinergic neuron; Biology; Cholinergic Fibers; Neurotransmitter; Central nervous system; Internal medicine; Endocrinology; Aché; Medicine; Biochemistry","authors":[{"name":"G. Andrew Reid","is_ca":true},{"name":"Nageswararao Chilukuri","is_ca":false},{"name":"Sultan Darvesh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0132230831819605,"gpt":0.2486849444316535,"spread":0.235461861249693,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003078713,0.0002946479,0.0002427068,0.00052711,0.0002270269,0.0007281521,0.0003121,0.0007897185,0.001722243],"category_scores_gemma":[0.0003031297,0.00007958781,0.00009460495,0.0003499814,0.0006878669,0.0007575416,0.0003198906,0.0007508876,0.0002520976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006200762,"about_ca_system_score_gemma":0.0006372079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003811995,"about_ca_topic_score_gemma":0.005354706,"domain_scores_codex":[0.9999256,0.00002234269,0.000006818115,0.00001014056,0.00001969163,0.00001547642],"domain_scores_gemma":[0.9998775,0.00004667464,0.0000277977,0.000007098117,0.0000209438,0.00001998233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005888609,0.001014921,0.02419023,0.003238999,0.0005596465,0.01130037,0.0008150142,0.002572953,0.2722287,0.09891552,0.01196253,0.5673124],"study_design_scores_gemma":[0.0006150214,0.002276756,0.2023059,0.001468757,0.0005632736,0.01847373,0.002220585,0.003292038,0.1299836,0.271432,0.3671897,0.0001786114],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0844041,0.8927119,0.0009388847,0.007866157,0.0003533206,0.00001155343,0.00007388654,0.00001211784,0.01362801],"genre_scores_gemma":[0.497078,0.4859329,0.001076612,0.001326088,0.001084353,0.00001661334,0.0001002313,0.000003239788,0.01338194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003811995,"threshold_uncertainty_score":0.007579565,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1585491343","doi":"10.1046/j.1365-2044.2000.055002144.x","title":"Succinylcholine‐associated postoperative myalgia","year":2000,"lang":"en","type":"review","venue":"Anaesthesia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"myalgia; Medicine; Anesthesia; Internal medicine","authors":[{"name":"Shanna Wong","is_ca":true},{"name":"Frances Chung","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05552194855066579,"gpt":0.3552293700819256,"spread":0.2997074215312598,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002622111,0.0009951849,0.001232747,0.001427779,0.0002313873,0.000519543,0.0005374451,0.0008326343,0.003177909],"category_scores_gemma":[0.000627662,0.0001678368,0.0003911427,0.001638936,0.000267325,0.000862995,0.0004091043,0.0007964081,0.002384809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002838038,"about_ca_system_score_gemma":0.0006138594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007951133,"about_ca_topic_score_gemma":0.001342005,"domain_scores_codex":[0.9998267,0.0000257707,0.00002919038,0.00002522409,0.00007448305,0.0000185596],"domain_scores_gemma":[0.99976,0.00009473094,0.00006469083,0.000008219334,0.00005093997,0.00002148988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001023778,0.0000868323,0.0005034561,0.01449956,0.00007761308,0.00130562,0.00005159345,0.0002161432,0.002230325,0.0006645824,0.02386844,0.9563934],"study_design_scores_gemma":[0.00008734502,0.0006707749,0.01118436,0.009988138,0.0003527334,0.04214226,0.0002088527,0.0002011407,0.002131304,0.001744821,0.9312456,0.00004271683],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003257854,0.9978103,0.0001027587,0.0001062279,0.0002778636,0.00000708601,0.0000123489,0.00000820361,0.00134941],"genre_scores_gemma":[0.001029233,0.9977422,0.00007805672,0.0001164712,0.0001862927,0.000005208083,0.00001928172,9.772381e-7,0.0008224086],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003177909,"threshold_uncertainty_score":0.01063114,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2044039824","doi":"10.1016/j.clinbiochem.2003.10.007","title":"Association of a salivary acetylcholinesterase with Alzheimer's disease and response to cholinesterase inhibitors","year":2003,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Alzheimer Society","keywords":"Acetylcholinesterase; Saliva; Aché; Cholinergic; Cholinesterase; Internal medicine; Endocrinology; Alzheimer's disease; Enzyme assay; Acetylcholine; Enzyme; Disease; Medicine; Psychology; Chemistry; Biochemistry","authors":[{"name":"Rachel Sayer","is_ca":false},{"name":"Emma Law","is_ca":false},{"name":"Peter Connelly","is_ca":false},{"name":"Kieran C. Breen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02978371459340179,"gpt":0.3461877500301836,"spread":0.3164040354367818,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001045703,0.0006344162,0.001001343,0.001219671,0.0007089964,0.0006752174,0.0004044836,0.00130744,0.001641312],"category_scores_gemma":[0.005388229,0.0003683985,0.001029422,0.001182329,0.000540952,0.0005828281,0.0003306507,0.002082632,0.0003570825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004294808,"about_ca_system_score_gemma":0.0004555273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002974555,"about_ca_topic_score_gemma":0.001783784,"domain_scores_codex":[0.9991426,0.00028053,0.000155473,0.0001106171,0.0001689153,0.0001418629],"domain_scores_gemma":[0.9948809,0.001842962,0.001319031,0.0003282733,0.0007302332,0.0008985474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002724758,0.0004229219,0.9897613,0.00003595318,0.0001925508,0.001837905,0.000142889,0.00005774481,0.002563378,0.00002712408,0.0001177908,0.002115735],"study_design_scores_gemma":[0.00003383223,0.001207163,0.9943374,0.000006236908,0.00009342252,0.003142569,0.0001853776,0.000212311,0.0004823758,0.00004434458,0.0002463404,0.000008617963],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970449,0.0007922255,0.0001439749,0.0002328941,0.00004558282,0.00002372708,0.0001452621,0.00001691936,0.001554541],"genre_scores_gemma":[0.9991767,0.0001117931,0.00006199663,0.00008976176,0.00003473523,0.00000833333,0.0001095351,0.000002520104,0.0004045671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002974555,"threshold_uncertainty_score":0.00591445,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1578593546","doi":"10.1177/070674371405901202","title":"Long-Term Efficacy and Toxicity of Cholinesterase Inhibitors in the Treatment of Alzheimer Disease","year":2014,"lang":"en","type":"review","venue":"The Canadian Journal of Psychiatry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Cholinesterase; Medicine; Disease; Rivastigmine; Pharmacotherapy; Adverse effect; Galantamine; Clinical trial; Donepezil; Alzheimer's disease; Intensive care medicine; Drug; Pharmacology; Dementia; Internal medicine","authors":[{"name":"David B. Hogan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05596237582289276,"gpt":0.352814153858675,"spread":0.2968517780357822,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007902326,0.0005688824,0.001699943,0.002196203,0.0002677298,0.0008141727,0.0007896699,0.00088029,0.00274952],"category_scores_gemma":[0.0009693963,0.0002220026,0.0006646002,0.00208997,0.0003633496,0.0006466506,0.0005233874,0.0008455386,0.0008073624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006412987,"about_ca_system_score_gemma":0.001366916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003021284,"about_ca_topic_score_gemma":0.007485068,"domain_scores_codex":[0.9997296,0.00005297535,0.0000559598,0.0000301962,0.0001113976,0.00001980991],"domain_scores_gemma":[0.9995901,0.0002070223,0.00007949568,0.000007498611,0.00008893801,0.00002697093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001291208,0.00006114272,0.0003299867,0.05799612,0.0003000337,0.0003408299,0.0001130761,0.0002563384,0.001100969,0.001566385,0.01100726,0.9267988],"study_design_scores_gemma":[0.00008717445,0.0002992871,0.005731854,0.03044638,0.001146078,0.004816979,0.0002517645,0.0001581248,0.0008639374,0.001951308,0.954201,0.00004620858],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000098537,0.9995607,0.00001333315,0.000056132,0.00002054233,0.000001579282,0.000006668406,9.516765e-7,0.0002416021],"genre_scores_gemma":[0.00068985,0.9990989,0.00003870737,0.00003620342,0.00002648967,0.000001936944,0.000008474797,3.120561e-7,0.00009911422],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003021284,"threshold_uncertainty_score":0.009198129,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1971352874","doi":"10.1185/030079903125002450","title":"Strategies for continued successful treatment of Alzheimer's disease: switching cholinesterase inhibitors","year":2003,"lang":"en","type":"review","venue":"Current Medical Research and Opinion","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Novartis Pharma; Novartis","keywords":"Medicine; Cholinesterase; Rivastigmine; Disease; Donepezil; Alzheimer's disease; Pharmacology; Intensive care medicine; Internal medicine; Dementia","authors":[{"name":"Serge Gauthier","is_ca":true},{"name":"Murat Emre","is_ca":false},{"name":"Martin R. Farlow","is_ca":false},{"name":"Roger Bullock","is_ca":false},{"name":"George T. Grossberg","is_ca":false},{"name":"Steven G. Potkin","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2977216713706416,"gpt":0.5340669825974191,"spread":0.2363453112267775,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005405375,0.0005976502,0.0007110457,0.0008243168,0.001096814,0.001853046,0.001158157,0.002708429,0.004692732],"category_scores_gemma":[0.006724298,0.000172798,0.0007360711,0.0004319143,0.0007057489,0.002363978,0.001851226,0.004268415,0.001518163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001437121,"about_ca_system_score_gemma":0.002955672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107833,"about_ca_topic_score_gemma":0.003390824,"domain_scores_codex":[0.9976707,0.0009956795,0.0002152625,0.0001998519,0.0006713906,0.0002471228],"domain_scores_gemma":[0.9973462,0.0008379778,0.0003655136,0.0001187055,0.0006609596,0.0006707077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002540954,0.001223944,0.003422198,0.001387533,0.0001087324,0.001288348,0.001730189,0.0005002393,0.003384651,0.009509437,0.1143374,0.8628532],"study_design_scores_gemma":[0.0009062034,0.002625865,0.02054622,0.005579003,0.0004398656,0.004795025,0.00472479,0.002663025,0.004262296,0.04625659,0.9070703,0.0001307884],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.08131345,0.1375519,0.04632755,0.6158518,0.007927611,0.001646474,0.0002333958,0.001090664,0.1080572],"genre_scores_gemma":[0.5272296,0.1169346,0.09957757,0.2104549,0.00971247,0.001646353,0.0006890408,0.000220586,0.03353503],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005405375,"threshold_uncertainty_score":0.02858675,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2559716120","doi":"10.1016/j.ejmech.2016.12.005","title":"2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"Ontario Mental Health Foundation; Canada Foundation for Innovation","keywords":"Chemistry; Cholinesterase; Antioxidant; Structure–activity relationship; Biochemistry; Pharmacology; Stereochemistry; In vitro","authors":[{"name":"Tarek Mohamed","is_ca":true},{"name":"Praveen P. N. Rao","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03986360962242318,"gpt":0.2761299765800019,"spread":0.2362663669575787,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003650002,0.0005609184,0.000372691,0.0002454649,0.0001596274,0.0002002094,0.000552293,0.0002888991,0.001887824],"category_scores_gemma":[0.0001729915,0.0001675471,0.0002446013,0.0002286782,0.0001834225,0.000304216,0.0001952781,0.0004543707,0.0004249109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215508,"about_ca_system_score_gemma":0.0002157506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007980745,"about_ca_topic_score_gemma":0.002270461,"domain_scores_codex":[0.9999273,0.00001835696,0.00000507508,0.00001196876,0.00001204654,0.00002520604],"domain_scores_gemma":[0.9999446,0.000009655862,0.00001498437,0.000005244007,0.00001323,0.0000122645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001601871,0.0005158809,0.0007006676,0.000745489,0.00008657276,0.0006868923,0.0002216381,0.002698874,0.9471127,0.001707027,0.00141309,0.04250911],"study_design_scores_gemma":[0.002019785,0.02428578,0.01208952,0.0001611331,0.0004513867,0.002672374,0.0001831002,0.009692751,0.9009764,0.0007822291,0.04655676,0.0001288557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9440541,0.03673812,0.0100233,0.0005036695,0.0001832825,0.0002500298,0.0006815067,0.0003135382,0.007252409],"genre_scores_gemma":[0.9784266,0.01310318,0.003752704,0.0001873227,0.00003696113,0.00007917132,0.0005006541,0.00001762509,0.003895849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887824,"threshold_uncertainty_score":0.00631541,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2139618199","doi":"10.1016/j.fitote.2011.11.009","title":"Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species","year":2011,"lang":"en","type":"article","venue":"Fitoterapia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Winnipeg","funders":"Manitoba Health Research Council","keywords":"Acetylcholinesterase; Biology; Traditional medicine; Anti-inflammatory; Chemistry; Pharmacology; Enzyme; Biochemistry; Medicine","authors":[{"name":"Abbas Mollataghi","is_ca":false},{"name":"Emilie Coudiere","is_ca":true},{"name":"A. Hamid A. Hadi","is_ca":false},{"name":"Mat Ropi Mukhtar","is_ca":false},{"name":"Khalijah Awang","is_ca":false},{"name":"Marc Litaudon","is_ca":false},{"name":"Athar Ata","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03783778328635093,"gpt":0.2627976238164224,"spread":0.2249598405300714,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007149199,0.0004827756,0.0002374754,0.0005469452,0.0002887449,0.0001453285,0.0001052143,0.0002087919,0.002385586],"category_scores_gemma":[0.0001032793,0.0001142053,0.0001975232,0.000241891,0.000227904,0.0001702088,0.0001544153,0.000376783,0.0002602249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001350993,"about_ca_system_score_gemma":0.0002862929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008905742,"about_ca_topic_score_gemma":0.001810738,"domain_scores_codex":[0.9999691,0.000004326786,0.000003823236,0.000005254719,0.000007947104,0.000009523746],"domain_scores_gemma":[0.9999261,0.00001407933,0.00001614333,0.000003994649,0.00001650884,0.00002322944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007800365,0.00009281608,0.0005644999,0.0001769009,0.00001845436,0.0001165696,0.00006093497,0.00007635308,0.9929247,0.00008219553,0.00006318651,0.005043293],"study_design_scores_gemma":[0.0001151478,0.004977132,0.02746252,0.0000506746,0.0001896214,0.0006061971,0.0001983769,0.0001479684,0.9607331,0.000141376,0.005360953,0.00001697683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938092,0.002542838,0.0005821187,0.0001101343,0.00002517072,0.00003796694,0.0003226495,0.00003037917,0.002539646],"genre_scores_gemma":[0.9929407,0.00234523,0.0009841827,0.0001047399,0.00001907424,0.00003496572,0.0004085154,0.000006012546,0.003156584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002385586,"threshold_uncertainty_score":0.007980585,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2990998939","doi":"10.3389/fphar.2019.01417","title":"Editorial: Natural Products-Based Drugs: Potential Therapeutics Against Alzheimer’s Disease and Other Neurological Disorders","year":2019,"lang":"en","type":"editorial","venue":"Frontiers in Pharmacology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Disease; Pharmacology; Drug discovery; Bioinformatics; Internal medicine; Biology","authors":[{"name":"Muhammad Ayaz","is_ca":false},{"name":"Farhat Ullah","is_ca":false},{"name":"Abdul Sadiq","is_ca":false},{"name":"Myeong Ok Kim","is_ca":false},{"name":"Tahir Ali","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01266131872007961,"gpt":0.3091947201337591,"spread":0.2965334014136795,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003729423,0.003986785,0.002805911,0.003100472,0.002542536,0.005023835,0.002634694,0.009231987,0.03200059],"category_scores_gemma":[0.01179633,0.000783338,0.002139639,0.001033003,0.00158082,0.004108339,0.001330376,0.01105652,0.02475262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001969449,"about_ca_system_score_gemma":0.001925082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007802823,"about_ca_topic_score_gemma":0.002641247,"domain_scores_codex":[0.9976532,0.0003859389,0.0002988811,0.0003197807,0.001168807,0.0001734146],"domain_scores_gemma":[0.9920017,0.002269758,0.0006798516,0.0001745236,0.003040818,0.001833383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004873982,0.00001063487,0.00001446818,0.0001934611,0.00001023489,0.00008037624,0.000006130411,0.00001608795,0.00006369221,0.0001438352,0.9943627,0.005049624],"study_design_scores_gemma":[0.00008167317,0.00004232996,0.0001951586,0.000349762,0.00004136651,0.0003508042,0.00002664703,0.0001056728,0.0001398065,0.0009250556,0.9977248,0.00001691277],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0000309213,0.005131036,0.00009566927,0.0200474,0.9725438,0.00002291886,0.00007256822,0.00005309381,0.002002584],"genre_scores_gemma":[0.0003361549,0.004605759,0.00008379859,0.01310821,0.9675913,0.00002032786,0.00005258775,0.0000282429,0.01417371],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.03200059,"threshold_uncertainty_score":0.1070526,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2607980041","doi":"10.3233/jad-170164","title":"Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer’s Disease","year":2017,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Nova Scotia Health Research Foundation; Dalhousie Medical Research Foundation","keywords":"Butyrylcholinesterase; Biomarker; Disease; Alzheimer's disease; Medicine; Neuroscience; Biology; Acetylcholinesterase; Internal medicine; Aché; Biochemistry; Enzyme","authors":[{"name":"Ian R. Macdonald","is_ca":true},{"name":"Selena P. Maxwell","is_ca":true},{"name":"G. Andrew Reid","is_ca":true},{"name":"Meghan K. Cash","is_ca":true},{"name":"Drew R. DeBay","is_ca":true},{"name":"Sultan Darvesh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09676233877570185,"gpt":0.3639690319512239,"spread":0.2672066931755221,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001551784,0.0008163491,0.0005551554,0.002138262,0.00027014,0.000610936,0.0002964035,0.000687343,0.0006467177],"category_scores_gemma":[0.001510156,0.000417813,0.0003011169,0.0008447144,0.0005276142,0.0006403213,0.0005234685,0.0005529886,0.0002630569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002944929,"about_ca_system_score_gemma":0.0002223411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302468,"about_ca_topic_score_gemma":0.002128883,"domain_scores_codex":[0.9991177,0.0002128783,0.00007352347,0.0002301917,0.0002905858,0.00007514683],"domain_scores_gemma":[0.9990801,0.0002915275,0.0002616068,0.00008192665,0.0002149101,0.00006998248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007293453,0.0001123163,0.04115666,0.0002840015,0.0002434539,0.0001600345,0.0002834136,0.001233946,0.9336155,0.0002765849,0.0002416006,0.02166324],"study_design_scores_gemma":[0.00004529467,0.001254136,0.3888827,0.00013738,0.0003808114,0.002311941,0.0003637561,0.02671065,0.5734807,0.001491508,0.004833167,0.0001078508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465973,0.01042057,0.03943963,0.00007915574,0.00005466715,0.00008856039,0.0005909711,0.0002952548,0.002434071],"genre_scores_gemma":[0.9464931,0.004027781,0.04688551,0.00009376175,0.00003906727,0.0001238974,0.0007170059,0.00003325603,0.001586596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138262,"threshold_uncertainty_score":0.008206666,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2162938476","doi":"10.2174/156720507781788774","title":"NGF-Cholinergic Dependency in Brain Aging, MCI and Alzheimers Disease","year":2007,"lang":"en","type":"review","venue":"Current Alzheimer Research","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Choline acetyltransferase; Cholinergic; Nerve growth factor; Basal forebrain; Nucleus basalis; Cholinergic neuron; Neurotrophin; Low-affinity nerve growth factor receptor; Neuroscience; Tropomyosin receptor kinase A; Alzheimer's disease; Internal medicine; Cholinergic Fibers; Endocrinology; Biology; Receptor; Medicine; Disease","authors":[{"name":"A. Claudio Cuello","is_ca":true},{"name":"Andreina Bruno","is_ca":false},{"name":"Kelly Bell","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.6198406789737027,"gpt":0.6079850944271186,"spread":0.01185558454658409,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655517,0.0004190041,0.0002513075,0.0004623884,0.0002047075,0.0003072421,0.0001530302,0.0002096777,0.000620046],"category_scores_gemma":[0.0001388462,0.00007901927,0.0001502583,0.0002051892,0.0002747516,0.0002139634,0.0002079943,0.000342983,0.0001328829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998615,"about_ca_system_score_gemma":0.0002508457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002147241,"about_ca_topic_score_gemma":0.003093723,"domain_scores_codex":[0.9999459,0.000008487833,0.000008100459,0.00001046334,0.00001839389,0.000008699115],"domain_scores_gemma":[0.9999306,0.000008892442,0.00002307448,0.000004917978,0.00001400396,0.00001844454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00485885,0.0004455201,0.04951096,0.001609308,0.0002156516,0.01227813,0.0004603933,0.0002393572,0.7950368,0.002449531,0.0007112183,0.1321843],"study_design_scores_gemma":[0.00008162652,0.003167201,0.8461567,0.0002413084,0.0003834717,0.01866441,0.0004196432,0.0003248587,0.1076277,0.002800691,0.02009357,0.00003885316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.804462,0.1895037,0.0004319256,0.0002216683,0.00007349535,0.00002700795,0.0002328223,0.00002765905,0.005019732],"genre_scores_gemma":[0.9428933,0.05368322,0.0004415601,0.00009626387,0.0001143105,0.00003476738,0.0002870057,0.000002733208,0.002446776],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002147241,"threshold_uncertainty_score":0.00426954,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}