{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":685,"total_is_capped":false,"direct_labels_cover":2,"predictions_cover":685,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"adc3bf7cb1d7","filters":{"topic":"Click Chemistry and Applications"}},"results":[{"id":"W2586637063","doi":"10.1038/s41467-016-0009-6","title":"In situ click chemistry generation of cyclooxygenase-2 inhibitors","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":7552,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Cyclooxygenase; Isozyme; In vivo; Chemistry; Click chemistry; Drug discovery; Gene isoform; Biochemistry; Enzyme; Computational biology; Combinatorial chemistry; Biology; Biotechnology; Gene","authors":[{"name":"Atul Bhardwaj","is_ca":true},{"name":"Jatinder Kaur","is_ca":true},{"name":"Melinda Wuest","is_ca":true},{"name":"Frank Wuest","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03519072533094404,"gpt":0.3287441936233204,"spread":0.2935534682923763,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003966264,0.0006860456,0.0003738836,0.0002779811,0.0001679805,0.000374097,0.0004350707,0.0004984188,0.001981409],"category_scores_gemma":[0.0002717519,0.0002252812,0.0004673358,0.000232566,0.0002309275,0.0005277696,0.0003635679,0.0008559676,0.0004932069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796006,"about_ca_system_score_gemma":0.0002669867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002277541,"about_ca_topic_score_gemma":0.0004273396,"domain_scores_codex":[0.9997475,0.00003279169,0.0000173398,0.00005521487,0.00007473821,0.0000724874],"domain_scores_gemma":[0.9998858,0.00002426249,0.00003848533,0.00001302796,0.00001634914,0.00002211751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001009038,0.0001088616,0.0001218523,0.0002017442,0.00002733033,0.0003044005,0.00004429564,0.0007702952,0.9876408,0.002229154,0.0007139599,0.00773649],"study_design_scores_gemma":[0.00002264811,0.0004022487,0.0002395465,0.000004239425,0.00001786716,0.000265169,0.000007435734,0.001580504,0.9921541,0.0001335787,0.005160143,0.00001259526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8083931,0.01007004,0.154343,0.001059814,0.0007430182,0.000376597,0.001032942,0.001266776,0.02271493],"genre_scores_gemma":[0.9682093,0.004003374,0.01888669,0.0002120709,0.00009165535,0.0001150365,0.00037127,0.00005787029,0.008052666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001981409,"threshold_uncertainty_score":0.006628454,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2120573543","doi":"10.1039/b507207g","title":"Organic chemistry in water","year":2005,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":1322,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Pericyclic reaction; Chemistry; Organic reaction; Reactivity (psychology); Carbocation; Organic chemistry; Aqueous solution; Catalysis; Carbanion; Solvent; Green chemistry; Organic synthesis; Reaction mechanism","authors":[{"name":"Chao‐Jun Li","is_ca":true},{"name":"Liang Chen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05751195356903484,"gpt":0.3387310897270362,"spread":0.2812191361580014,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003899743,0.001005287,0.0006361564,0.0009574728,0.0007918771,0.001329777,0.0006975759,0.001307482,0.01692311],"category_scores_gemma":[0.0003853517,0.0003386409,0.000256026,0.001247162,0.00118074,0.00262302,0.00194975,0.002257749,0.01953237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001216972,"about_ca_system_score_gemma":0.0009532297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009290949,"about_ca_topic_score_gemma":0.001650103,"domain_scores_codex":[0.9996796,0.00004037052,0.00001701004,0.00005916322,0.0001571769,0.00004665258],"domain_scores_gemma":[0.9999087,0.00001697679,0.0000120907,0.00001257139,0.00002847929,0.00002125698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003547114,0.00007587323,0.00009457698,0.003068401,0.00002556102,0.0003457294,0.0002676983,0.0004523757,0.01880064,0.08498405,0.137098,0.7547517],"study_design_scores_gemma":[0.000003217815,0.00001408538,0.00004110853,0.0001779911,0.000001952502,0.0001252197,0.00001690283,0.00002632005,0.001088382,0.003913251,0.9945881,0.000003345772],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001176011,0.8606142,0.004497414,0.003012535,0.007540759,0.00007120643,0.00008158829,0.000149594,0.1228568],"genre_scores_gemma":[0.01268477,0.8101993,0.00381666,0.003049699,0.002738743,0.000126055,0.0001540538,0.00004399007,0.1671868],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01692311,"threshold_uncertainty_score":0.05661339,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1516646538","doi":"10.1038/nchembio.1867","title":"The promise and peril of chemical probes","year":2015,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":850,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; University of Toronto; Simon Fraser University; Structural Genomics Consortium; Princess Margaret Cancer Centre","funders":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill; National Institute of General Medical Sciences; Medical Research Council; Novartis Institutes for BioMedical Research; University of North Carolina at Chapel Hill; Janssen Research and Development; National Institutes of Health; University of Toronto; Harvard University; Österreichischen Akademie der Wissenschaften; Monash University; Cancer Research UK; National Center for Advancing Translational Sciences; Wellcome Trust; GlaxoSmithKline; Constellation Pharmaceuticals; Eli Lilly and Company; University of Dundee; University of Oxford; Pfizer","keywords":"Quality (philosophy); Computer science; Data science; Resource (disambiguation); Risk analysis (engineering); Business; Epistemology","authors":[{"name":"C.H. Arrowsmith","is_ca":true},{"name":"James E. Audia","is_ca":false},{"name":"Christopher P. Austin","is_ca":false},{"name":"Jonathan B. Baell","is_ca":false},{"name":"Jonathan P. Bennett","is_ca":false},{"name":"Julian Blagg","is_ca":false},{"name":"C. Bountra","is_ca":false},{"name":"Paul E. Brennan","is_ca":false},{"name":"Peter J. Brown","is_ca":true},{"name":"Mark E. Bunnage","is_ca":false},{"name":"Carolyn Buser‐Doepner","is_ca":false},{"name":"Adrian J. Carter","is_ca":false},{"name":"Philip Cohen","is_ca":false},{"name":"Robert A. Copeland","is_ca":false},{"name":"Ben Cravatt","is_ca":false},{"name":"Jayme L. Dahlin","is_ca":false},{"name":"Dashyant Dhanak","is_ca":false},{"name":"A.M. Edwards","is_ca":true},{"name":"Mathias Frederiksen","is_ca":false},{"name":"Stephen V. Frye","is_ca":false},{"name":"Nathanael S. Gray","is_ca":false},{"name":"Charles E. Grimshaw","is_ca":false},{"name":"David Hepworth","is_ca":false},{"name":"Trevor Howe","is_ca":false},{"name":"K. Huber","is_ca":false},{"name":"Jian Jin","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Joanne Kotz","is_ca":false},{"name":"Ryan G. Kruger","is_ca":false},{"name":"Derek Lowe","is_ca":false},{"name":"Mary M. Mader","is_ca":false},{"name":"Brian D. Marsden","is_ca":false},{"name":"Anke Mueller‐Fahrnow","is_ca":false},{"name":"Susanne Müller","is_ca":false},{"name":"Rónán C. O’Hagan","is_ca":false},{"name":"John P. Overington","is_ca":false},{"name":"Dafydd R. Owen","is_ca":false},{"name":"Saul H. Rosenberg","is_ca":false},{"name":"Ruth A. Ross","is_ca":true},{"name":"Bryan L. Roth","is_ca":false},{"name":"Matthieu Schapira","is_ca":true},{"name":"Stuart L. Schreiber","is_ca":false},{"name":"Brian K. Shoichet","is_ca":false},{"name":"M. Sundström","is_ca":false},{"name":"Giulio Superti-Furga","is_ca":false},{"name":"Jack Taunton","is_ca":false},{"name":"Leticia Toledo‐Sherman","is_ca":false},{"name":"Chris Walpole","is_ca":true},{"name":"Michael A. Walters","is_ca":false},{"name":"Timothy M. Willson","is_ca":false},{"name":"Paul Workman","is_ca":false},{"name":"Robert N. Young","is_ca":true},{"name":"William J. Zuercher","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01197405333482197,"gpt":0.2792166934164036,"spread":0.2672426400815816,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02804844,0.001078899,0.0009776107,0.002448606,0.002563085,0.01031308,0.003097337,0.008119388,0.01579986],"category_scores_gemma":[0.04768088,0.0007135879,0.0009158943,0.001775143,0.007644267,0.03386348,0.006737324,0.01277172,0.006843123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002453527,"about_ca_system_score_gemma":0.003671446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008458304,"about_ca_topic_score_gemma":0.0009498495,"domain_scores_codex":[0.9870368,0.004724394,0.0004786688,0.0009967729,0.006205832,0.000557459],"domain_scores_gemma":[0.9514719,0.02946743,0.001658552,0.005284009,0.006509816,0.005608364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002784833,0.0001523704,0.0008456186,0.001814967,0.00007241439,0.0003846656,0.0008107033,0.001024751,0.01074967,0.4828773,0.1867631,0.314226],"study_design_scores_gemma":[0.0000207251,0.00008154164,0.0001873857,0.0003320757,0.00001751084,0.0002804798,0.0003372715,0.0008093223,0.005083712,0.1326917,0.8601155,0.00004282664],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01045219,0.2033983,0.1168408,0.5289795,0.03277991,0.0001439388,0.001468942,0.005474475,0.100462],"genre_scores_gemma":[0.2178064,0.2931119,0.1915341,0.1642271,0.02462478,0.0009162977,0.003132822,0.003440838,0.1012058],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02804844,"threshold_uncertainty_score":0.1483361,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1968280004","doi":"10.1016/j.biomaterials.2014.03.001","title":"Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering","year":2014,"lang":"en","type":"review","venue":"Biomaterials","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":751,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"","keywords":"Self-healing hydrogels; Click chemistry; Bioorthogonal chemistry; Drug delivery; Biocompatibility; Tissue engineering; Materials science; Nanotechnology; Chemistry; Polymer chemistry; Biomedical engineering","authors":[{"name":"Yanjiao Jiang","is_ca":false},{"name":"Jing Chen","is_ca":false},{"name":"Chao Deng","is_ca":false},{"name":"Erik J. Suuronen","is_ca":true},{"name":"Zhiyuan Zhong","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02553351746365706,"gpt":0.3000144612133964,"spread":0.2744809437497394,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004949961,0.001044556,0.0008762137,0.001381967,0.0001920121,0.0009481211,0.000733546,0.001079145,0.00206048],"category_scores_gemma":[0.0003912051,0.0003171418,0.0002723483,0.001722165,0.0005449805,0.00155161,0.0006524493,0.001482503,0.001601902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005406901,"about_ca_system_score_gemma":0.0006168493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004055251,"about_ca_topic_score_gemma":0.001262767,"domain_scores_codex":[0.9998235,0.00001537898,0.00001257079,0.00003400485,0.00008807982,0.00002650269],"domain_scores_gemma":[0.9998447,0.00005986422,0.00003104983,0.000004712508,0.00003332346,0.00002629045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001228127,0.0001617397,0.0001477452,0.008476194,0.00006319951,0.0003568337,0.00006213353,0.0005209266,0.04992827,0.009125738,0.03281038,0.8982241],"study_design_scores_gemma":[0.00002942942,0.000200984,0.0005479933,0.0006898528,0.00007368552,0.001289093,0.00005227089,0.0003060551,0.01911971,0.002205945,0.9754423,0.0000426481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001020764,0.9938173,0.001536052,0.0003769374,0.0005357633,0.00001139734,0.00004546062,0.00003503897,0.002621329],"genre_scores_gemma":[0.005501166,0.9870002,0.001230864,0.0005056725,0.0004470284,0.0000209388,0.00006934419,0.000006485784,0.005218363],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00206048,"threshold_uncertainty_score":0.006892979,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4211115069","doi":"10.1038/s43586-021-00028-z","title":"Bioorthogonal chemistry","year":2021,"lang":"nl","type":"article","venue":"Nature Reviews Methods Primers","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":559,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences","keywords":"Bioorthogonal chemistry; Chemistry; Chemical biology; Click chemistry; Combinatorial chemistry; Bioconjugation; Tetrazine; Nanotechnology; Organic chemistry; Biochemistry; Materials science","authors":[{"name":"Samuel L. Scinto","is_ca":false},{"name":"Didier A. Bilodeau","is_ca":true},{"name":"Robert Hincapie","is_ca":false},{"name":"Wankyu Lee","is_ca":false},{"name":"Sean S. Nguyen","is_ca":false},{"name":"Minghao Xu","is_ca":false},{"name":"Christopher W. am Ende","is_ca":false},{"name":"M. G. Finn","is_ca":false},{"name":"Kathrin Lang","is_ca":false},{"name":"Qing Lin","is_ca":false},{"name":"John Paul Pezacki","is_ca":true},{"name":"Jennifer A. Prescher","is_ca":false},{"name":"Marc S. Robillard","is_ca":false},{"name":"Joseph M. Fox","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04084773897256575,"gpt":0.4271638263924606,"spread":0.3863160874198948,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007608272,0.001107556,0.0004603559,0.0008225113,0.000534404,0.001061155,0.0008863664,0.001331238,0.01162895],"category_scores_gemma":[0.0004105197,0.0005792897,0.0003749759,0.000555967,0.0005738255,0.00119226,0.001486235,0.002154156,0.01173821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006567677,"about_ca_system_score_gemma":0.0006365876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002785027,"about_ca_topic_score_gemma":0.0006286968,"domain_scores_codex":[0.9992872,0.0000977907,0.00003666179,0.0001642532,0.000284845,0.0001293218],"domain_scores_gemma":[0.9998603,0.0000221664,0.00002541194,0.00003765271,0.00003285455,0.00002160461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000135109,0.0002195773,0.0002208028,0.001003622,0.00007526146,0.0002378613,0.0001853365,0.0002274835,0.6550327,0.08993293,0.04133355,0.2113958],"study_design_scores_gemma":[0.0000203782,0.0001654602,0.0002178741,0.0000458287,0.00002094598,0.0003959441,0.00003176705,0.0004843646,0.610153,0.005131375,0.3833083,0.00002482122],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.07084256,0.06349161,0.388467,0.004707004,0.007691151,0.001225384,0.002273137,0.004282359,0.4570199],"genre_scores_gemma":[0.3833649,0.0507481,0.1231745,0.00385696,0.001493355,0.001290095,0.003999785,0.000540077,0.4315321],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01162895,"threshold_uncertainty_score":0.03890276,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2000998282","doi":"10.1021/ja2083027","title":"Cellular Consequences of Copper Complexes Used To Catalyze Bioorthogonal Click Reactions","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":395,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada; University of Ottawa; Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research","keywords":"Bioorthogonal chemistry; Chemistry; Copper; Click chemistry; Histidine; Ligand (biochemistry); Cycloaddition; Toxicity; Catalysis; Metabolism; Copper toxicity; Combinatorial chemistry; Redox; Biochemistry; Biophysics; Organic chemistry; Enzyme; Receptor","authors":[{"name":"David C. Kennedy","is_ca":true},{"name":"Craig S. McKay","is_ca":true},{"name":"Marc C.B. Legault","is_ca":true},{"name":"Dana C. Danielson","is_ca":true},{"name":"Jessie A. Blake","is_ca":true},{"name":"Adrian F. Pegoraro","is_ca":true},{"name":"Albert Stolow","is_ca":true},{"name":"Zoltán Mester","is_ca":true},{"name":"John Paul Pezacki","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0473036178858312,"gpt":0.2819538228099002,"spread":0.234650204924069,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002420973,0.0004209199,0.0004340078,0.00014792,0.0001788113,0.0003793384,0.0002077173,0.0003748515,0.0007161457],"category_scores_gemma":[0.0002466238,0.0001428382,0.0001953486,0.0002426297,0.0002339734,0.0002247318,0.0002451873,0.0003350184,0.0001789756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003255482,"about_ca_system_score_gemma":0.0001599859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117904,"about_ca_topic_score_gemma":0.001392202,"domain_scores_codex":[0.9996346,0.0001264227,0.0000346802,0.00006139927,0.00007813038,0.0000646694],"domain_scores_gemma":[0.9998057,0.00005272686,0.00004098672,0.00002463249,0.00005339043,0.00002247254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001666132,0.00002476007,0.0001422196,0.00005722256,0.00001024752,0.00006592196,0.00003976314,0.00006583137,0.9983631,0.00006721023,0.00006325768,0.0009338304],"study_design_scores_gemma":[0.000004010786,0.0002934698,0.0007582511,0.0000022104,0.000009486856,0.00005661104,0.00003096776,0.000242562,0.9980431,0.00001168546,0.0005453191,0.00000226518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933943,0.001838808,0.002910619,0.00007552675,0.00003947245,0.0000278466,0.0002353382,0.000106179,0.00137194],"genre_scores_gemma":[0.9953181,0.0008886603,0.001628909,0.00004913141,0.000008018418,0.00003792022,0.0003170706,0.00001684604,0.001735346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117904,"threshold_uncertainty_score":0.002395749,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2153004011","doi":"10.1039/b913281n","title":"“Click” methodologies: efficient, simple and greener routes to design dendrimers","year":2010,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":342,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Dendrimer; Click chemistry; Computer science; Nanotechnology; Simplicity; Macromolecule; Chemistry; Biochemical engineering; Combinatorial chemistry; Materials science; Engineering; Organic chemistry","authors":[{"name":"Grégory Franc","is_ca":true},{"name":"Ashok Kakkar","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2283177454091215,"gpt":0.4213201254148159,"spread":0.1930023800056944,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006056657,0.001056715,0.0005498045,0.001214043,0.0002747332,0.0004929634,0.0008678834,0.0007646041,0.002035749],"category_scores_gemma":[0.0003509038,0.0003999923,0.0004061722,0.0008855859,0.0005770623,0.001528779,0.0005664296,0.00139364,0.001984639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005853296,"about_ca_system_score_gemma":0.0003498386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003336533,"about_ca_topic_score_gemma":0.0006841052,"domain_scores_codex":[0.9997208,0.00003581597,0.00002203849,0.00005179542,0.0001324696,0.0000370799],"domain_scores_gemma":[0.9999285,0.00002036047,0.00001482352,0.00000768705,0.00001814831,0.00001060875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001329589,0.0003605272,0.0001890957,0.00750107,0.0001172939,0.00100788,0.0002714772,0.002739082,0.3946609,0.05442478,0.01924879,0.5193462],"study_design_scores_gemma":[0.00006934335,0.0004431092,0.0004819335,0.000315828,0.00004071496,0.002334261,0.00003925914,0.001432594,0.240387,0.003371735,0.75101,0.00007425273],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03236685,0.815495,0.1046594,0.001700703,0.002453702,0.0005751369,0.0002842323,0.0009629711,0.04150205],"genre_scores_gemma":[0.09148862,0.8090115,0.05850409,0.001450293,0.0006938661,0.0004767014,0.0003469949,0.0000915926,0.03793642],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002035749,"threshold_uncertainty_score":0.006810248,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2949252818","doi":"10.1021/jacs.9b02822","title":"Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":342,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Medical Research Council; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ministry of Science and Technology, Israel; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; Wellcome; Merck KGaA; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Rising Tide Foundation; Pfizer; Israel Science Foundation; Israel Cancer Research Fund","keywords":"Chemistry; Electrophile; Covalent bond; Ligand efficiency; Combinatorial chemistry; Drug discovery; Fragment (logic); Ligand (biochemistry); Cysteine; Selectivity; Deubiquitinating enzyme; Stereochemistry; High-throughput screening; Enzyme; Biochemistry; Organic chemistry; Receptor; Gene; Ubiquitin","authors":[{"name":"Efrat Resnick","is_ca":false},{"name":"A.R. Bradley","is_ca":false},{"name":"Jinrui Gan","is_ca":false},{"name":"A. Douangamath","is_ca":false},{"name":"T. Krojer","is_ca":false},{"name":"Ritika Sethi","is_ca":false},{"name":"Paul P. Geurink","is_ca":false},{"name":"A. Aimon","is_ca":false},{"name":"Gabriel Amitai","is_ca":false},{"name":"Dom Bellini","is_ca":false},{"name":"James M. Bennett","is_ca":false},{"name":"M. Fairhead","is_ca":false},{"name":"Oleg Fedorov","is_ca":false},{"name":"Ronen Gabizon","is_ca":false},{"name":"Jingxu Guo","is_ca":false},{"name":"A.N. Plotnikov","is_ca":false},{"name":"Nava Reznik","is_ca":false},{"name":"G.F. Ruda","is_ca":false},{"name":"L. Diaz Saez","is_ca":false},{"name":"Verena M. Straub","is_ca":false},{"name":"Tamás Szommer","is_ca":false},{"name":"Srikannathasan Velupillai","is_ca":false},{"name":"Daniel Zaidman","is_ca":false},{"name":"Yanling Zhang","is_ca":false},{"name":"Alun R. Coker","is_ca":false},{"name":"Christopher G. Dowson","is_ca":false},{"name":"Haim Barr","is_ca":false},{"name":"Chu Wang","is_ca":false},{"name":"K. Huber","is_ca":false},{"name":"Paul E. Brennan","is_ca":false},{"name":"Huib Ovaa","is_ca":false},{"name":"F. von Delft","is_ca":false},{"name":"Nir London","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008438640852305347,"gpt":0.2361901191006167,"spread":0.2277514782483114,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001426619,0.001170935,0.0006910135,0.0006697049,0.0003511611,0.0005979565,0.0006597168,0.0005427635,0.003272665],"category_scores_gemma":[0.0009776959,0.0003243338,0.0005610251,0.0006855465,0.0004324795,0.0007193088,0.0009287462,0.000963534,0.001019763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000506661,"about_ca_system_score_gemma":0.0003460369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003054205,"about_ca_topic_score_gemma":0.0009267207,"domain_scores_codex":[0.9992441,0.0001447958,0.00005344146,0.0001664879,0.000236566,0.0001546252],"domain_scores_gemma":[0.9996141,0.0001322728,0.00006972177,0.00007749711,0.00006240343,0.00004392401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002040573,0.0001721337,0.0004516179,0.0001911275,0.00005388943,0.000242118,0.0000778742,0.001292787,0.9693654,0.001444889,0.0006734568,0.02583065],"study_design_scores_gemma":[0.00002680331,0.000701892,0.0004710572,0.000006873177,0.0000253651,0.0002398632,0.00001600873,0.001375179,0.9915786,0.0002436226,0.00529665,0.00001808225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6626824,0.006004455,0.3091849,0.0004544584,0.0001378753,0.001806626,0.002396508,0.002550772,0.01478215],"genre_scores_gemma":[0.9155945,0.004240435,0.06673543,0.0002623768,0.00003823745,0.0009125254,0.002253576,0.00019048,0.009772545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003272665,"threshold_uncertainty_score":0.01094812,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2791054012","doi":"10.1002/chem.201705499","title":"The Hydrophobic Effect Applied to Organic Synthesis: Recent Synthetic Chemistry “in Water”","year":2018,"lang":"en","type":"review","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":340,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Miller Group (Canada)","funders":"Novartis; National Science Foundation","keywords":"Nanoreactor; Micelle; Amphiphile; Aqueous solution; Catalysis; Chemistry; Organic synthesis; Transition metal; Organic chemistry; Nanotechnology; Materials science; Copolymer; Polymer","authors":[{"name":"Bruce H. Lipshutz","is_ca":false},{"name":"Subir Ghorai","is_ca":true},{"name":"Margery Cortes‐Clerget","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02010859393561351,"gpt":0.2613562540566282,"spread":0.2412476601210146,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007444304,0.0008114146,0.0005300258,0.001395701,0.0003962251,0.0007922028,0.0005357908,0.0009002194,0.002571668],"category_scores_gemma":[0.0007238442,0.0004378903,0.0003177538,0.001726902,0.001201199,0.001745636,0.0009685769,0.001950855,0.002192691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008352272,"about_ca_system_score_gemma":0.0006936095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008286617,"about_ca_topic_score_gemma":0.001067235,"domain_scores_codex":[0.9997447,0.00003985825,0.00002878913,0.00006893256,0.00008524438,0.00003239451],"domain_scores_gemma":[0.9996496,0.0001582147,0.00004282179,0.00002482474,0.00009428311,0.0000302535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005391641,0.00008467612,0.0001474461,0.01238532,0.00005458193,0.0002402714,0.0001623217,0.0006971502,0.02157506,0.02747671,0.02151323,0.9156093],"study_design_scores_gemma":[0.000006351807,0.00008147156,0.0002045267,0.0005590135,0.0000215689,0.0005303129,0.00003357454,0.00009768461,0.006430178,0.002653973,0.9893644,0.00001690689],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006288293,0.9930093,0.001280963,0.0004896467,0.0006248986,0.00001032936,0.00001285627,0.00001592044,0.003927214],"genre_scores_gemma":[0.004524742,0.9902239,0.001203532,0.000497873,0.0005265934,0.0000175352,0.00002444053,0.000007420575,0.002973852],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002571668,"threshold_uncertainty_score":0.008603096,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3013682926","doi":"10.1039/c9cs00720b","title":"Advances in covalent kinase inhibitors","year":2020,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":323,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canadian Celiac Association; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Stichting Tegen Kanker; Canadian Institutes of Health Research; Austrian Science Fund","keywords":"Covalent bond; Electrophile; Cysteine; Nucleophile; Covalent binding; Chemistry; Combinatorial chemistry; Nanotechnology; Biochemistry; Enzyme; Organic chemistry; Materials science","authors":[{"name":"Ayah Abdeldayem","is_ca":true},{"name":"Yasir S. Raouf","is_ca":true},{"name":"Stefan N. Constantinescu","is_ca":false},{"name":"Richard Moriggl","is_ca":false},{"name":"Patrick T. Gunning","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05263339381324837,"gpt":0.3546244267497739,"spread":0.3019910329365255,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001017585,0.001002476,0.0008691533,0.002246005,0.0004210474,0.001275253,0.0009029434,0.001054526,0.00796742],"category_scores_gemma":[0.001111734,0.0005236686,0.0007607366,0.001778626,0.0005243559,0.002233676,0.0009991066,0.002757489,0.003455802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007368069,"about_ca_system_score_gemma":0.0008927109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007290315,"about_ca_topic_score_gemma":0.001368851,"domain_scores_codex":[0.9994249,0.000070344,0.00005373065,0.0001200726,0.0002547726,0.00007626766],"domain_scores_gemma":[0.9995728,0.0001972312,0.00006650263,0.00002005534,0.0001070825,0.00003625139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001222944,0.0002214939,0.0003917282,0.02191109,0.0001258215,0.000489343,0.0001725573,0.001289855,0.01548171,0.03560225,0.04846102,0.8757309],"study_design_scores_gemma":[0.00001410184,0.0001560904,0.0002849005,0.0007676674,0.00004964165,0.0006711793,0.00003248316,0.000221093,0.004525839,0.002287077,0.990972,0.00001783321],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009195764,0.9883146,0.001402719,0.0005529695,0.0005373119,0.00002257973,0.00008851862,0.00005161784,0.00810998],"genre_scores_gemma":[0.006316826,0.988387,0.00089134,0.0004831462,0.0003861039,0.00002830045,0.0001196908,0.00000925423,0.003378269],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00796742,"threshold_uncertainty_score":0.02665365,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2622009965","doi":"10.1016/j.ejmech.2017.06.019","title":"Covalent inhibitors design and discovery","year":2017,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":313,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Covalent bond; Chemistry; Drug discovery; Combinatorial chemistry; Computational biology; Biochemical engineering; Nanotechnology; Biochemistry; Organic chemistry; Engineering; Biology; Materials science","authors":[{"name":"Stéphane De Cesco","is_ca":true},{"name":"Jerry Kurian","is_ca":true},{"name":"Caroline Dufresne","is_ca":true},{"name":"Anthony Mittermaier","is_ca":true},{"name":"Nicolas Moitessier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1170122075022246,"gpt":0.3488963609730948,"spread":0.2318841534708702,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001026335,0.001489154,0.001487429,0.001835486,0.0003322252,0.001710556,0.001391979,0.001187031,0.003721661],"category_scores_gemma":[0.0009923531,0.0006534194,0.0006651366,0.001726884,0.0008004336,0.001900187,0.001417526,0.002667315,0.002586073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007135145,"about_ca_system_score_gemma":0.001080628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004110513,"about_ca_topic_score_gemma":0.0008753033,"domain_scores_codex":[0.9995987,0.00004678237,0.00003257444,0.00006362335,0.0001795486,0.00007879456],"domain_scores_gemma":[0.999715,0.00009396505,0.00006984714,0.00001979402,0.00006107877,0.00004025569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001475123,0.0001419678,0.0001317914,0.007399327,0.0001331354,0.0002377947,0.00005900054,0.0009719287,0.009295141,0.01543231,0.03735762,0.9286925],"study_design_scores_gemma":[0.00004902589,0.0002052668,0.0002807755,0.0008925044,0.0001402024,0.0007424646,0.00001873248,0.0006159387,0.00740276,0.003487315,0.9861377,0.00002741347],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001211995,0.984176,0.006381624,0.0006028785,0.001084484,0.00005723667,0.00008408161,0.0001228973,0.006278844],"genre_scores_gemma":[0.01088796,0.9748628,0.003356089,0.000974029,0.0007168692,0.00006706787,0.0001963961,0.0000217311,0.008917252],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003721661,"threshold_uncertainty_score":0.01245016,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2781191952","doi":"10.1021/jacs.7b08366","title":"“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":305,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Hewitt Foundation; Leukemia and Lymphoma Society","keywords":"Chemistry; Electrophile; Aryl; Drug discovery; Combinatorial chemistry; Small molecule; Covalent bond; Bioorthogonal chemistry; Conjugate; Stereochemistry; Biochemistry; Click chemistry; Organic chemistry","authors":[{"name":"D.E. Mortenson","is_ca":false},{"name":"Gabriel J. Brighty","is_ca":false},{"name":"Lars Plate","is_ca":false},{"name":"Grant A. L. Bare","is_ca":false},{"name":"Wentao Chen","is_ca":false},{"name":"Suhua Li","is_ca":false},{"name":"Hua Wang","is_ca":false},{"name":"Benjamin F. Cravatt","is_ca":false},{"name":"Stefano Forli","is_ca":false},{"name":"Evan T. Powers","is_ca":false},{"name":"K. Barry Sharpless","is_ca":false},{"name":"Ian A. Wilson","is_ca":false},{"name":"Jeffery W. Kelly","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0147485627568172,"gpt":0.2843429452222869,"spread":0.2695943824654697,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003726569,0.0005264728,0.0003026016,0.0002656666,0.000144048,0.0002924948,0.0003727621,0.0004227192,0.001230256],"category_scores_gemma":[0.0002381372,0.000154945,0.0003092684,0.0001631013,0.0003750694,0.0003896954,0.0005250363,0.0007448015,0.0004001025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296777,"about_ca_system_score_gemma":0.0002228041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001535457,"about_ca_topic_score_gemma":0.0003054622,"domain_scores_codex":[0.9998281,0.00004020062,0.0000138403,0.00004013243,0.00004078959,0.00003699438],"domain_scores_gemma":[0.9998964,0.00002575745,0.00003261672,0.000016349,0.00001381337,0.0000149953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002024962,0.00008868729,0.0002268053,0.0001686202,0.00002080063,0.0002126796,0.00005562992,0.0005794439,0.9794002,0.003629306,0.0003859903,0.01502944],"study_design_scores_gemma":[0.00003312627,0.0008639217,0.0003083783,0.000007293285,0.00002137027,0.0003633027,0.00001568964,0.001498044,0.9878763,0.0003962499,0.008606176,0.00001015857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8141829,0.00599965,0.1605307,0.0009959209,0.0002128153,0.0006830494,0.0005316374,0.0008617443,0.01600153],"genre_scores_gemma":[0.9446397,0.003789946,0.04322155,0.0003935265,0.00003759015,0.0002384164,0.0003640705,0.00004390825,0.007271234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230256,"threshold_uncertainty_score":0.004115641,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2401258374","doi":"10.1021/jm200452d","title":"Matched Molecular Pairs as a Medicinal Chemistry Tool","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":287,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Citation; Library science; Chemistry; Computer science","authors":[{"name":"Ed Griffen","is_ca":false},{"name":"Andrew G. Leach","is_ca":false},{"name":"Graeme R. Robb","is_ca":false},{"name":"Daniel J. Warner","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0169557843249972,"gpt":0.2522057431977696,"spread":0.2352499588727724,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00562686,0.00186342,0.001202617,0.004584915,0.0009618038,0.004024857,0.002646461,0.001663822,0.2341013],"category_scores_gemma":[0.01546156,0.001137956,0.00140337,0.00347334,0.0006846488,0.005819552,0.005137756,0.002022974,0.1004635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008622463,"about_ca_system_score_gemma":0.00111498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002534421,"about_ca_topic_score_gemma":0.0003688733,"domain_scores_codex":[0.9961897,0.001241865,0.0003761893,0.0004565512,0.00144997,0.0002856852],"domain_scores_gemma":[0.9945919,0.002431671,0.0004354094,0.00129893,0.0006719108,0.000570239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009459958,0.0003962059,0.001114584,0.0009151233,0.00008554151,0.0007551478,0.0001604004,0.002339786,0.005611135,0.07914256,0.3348765,0.5736571],"study_design_scores_gemma":[0.000338529,0.0003940435,0.0005458943,0.0001955446,0.00006442321,0.0008298957,0.00008585063,0.01778347,0.01429287,0.1108179,0.8545538,0.00009767242],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.008847824,0.004080049,0.6202553,0.005280559,0.002967451,0.001572639,0.02250567,0.1521514,0.1823391],"genre_scores_gemma":[0.1020315,0.004799463,0.759543,0.003109775,0.001279352,0.001862023,0.03798286,0.01135964,0.07803234],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2341013,"threshold_uncertainty_score":0.7831469,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3160292980","doi":"10.1038/s41565-021-00910-7","title":"Bioorthogonal catalytic patch","year":2021,"lang":"nl","type":"article","venue":"Nature Nanotechnology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":244,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Argonne National Laboratory; Office of Science; North Carolina State University; Jonsson Comprehensive Cancer Center; Zhejiang University; Canadian Light Source; Alfred P. Sloan Foundation; Fuzhou University; U.S. Department of Energy; University of North Carolina at Chapel Hill; National Science Foundation","keywords":"Bioorthogonal chemistry; Prodrug; Catalysis; Chemistry; Combinatorial chemistry; Nanotechnology; Biomolecule; In vivo; Drug delivery; Materials science; Click chemistry; Biochemistry; Biology","authors":[{"name":"Zhaowei Chen","is_ca":false},{"name":"Hongjun Li","is_ca":false},{"name":"Yijie Bian","is_ca":false},{"name":"Zejun Wang","is_ca":false},{"name":"Guojun Chen","is_ca":false},{"name":"Xudong Zhang","is_ca":false},{"name":"Yimin Miao","is_ca":false},{"name":"Di Wen","is_ca":false},{"name":"Jinqiang Wang","is_ca":false},{"name":"Gang Wan","is_ca":false},{"name":"Yi Zeng","is_ca":false},{"name":"Peter Abdou","is_ca":false},{"name":"Jun Fang","is_ca":false},{"name":"Song Li","is_ca":false},{"name":"Cheng‐Jun Sun","is_ca":false},{"name":"Zhen Gu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007330095848231417,"gpt":0.2572611884575289,"spread":0.2499310926092975,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183871,0.0004075809,0.0003002572,0.000175135,0.0002273334,0.0004340151,0.0007110508,0.0007079793,0.009125017],"category_scores_gemma":[0.0001981817,0.0002606995,0.000244476,0.0001913264,0.0002470112,0.0004550757,0.0005182405,0.0008651323,0.003949657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248116,"about_ca_system_score_gemma":0.0001843216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002126143,"about_ca_topic_score_gemma":0.0003152397,"domain_scores_codex":[0.9997215,0.00001641631,0.000009554953,0.0001183682,0.0000664959,0.00006768014],"domain_scores_gemma":[0.9999129,0.00001266119,0.00001445275,0.00003415946,0.00001151847,0.00001438515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141495,0.00005176254,0.0001002207,0.00008516882,0.00001019578,0.0001322107,0.00004570006,0.00006618156,0.9804145,0.003887722,0.001658303,0.01343389],"study_design_scores_gemma":[0.00001582089,0.0001068314,0.0002594289,0.00000325031,0.000007922246,0.0002193001,0.000012923,0.0003700237,0.9805803,0.000189796,0.01822953,0.00000479117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7856881,0.002409708,0.09375751,0.001191498,0.0008622337,0.0004481339,0.001419803,0.002241108,0.1119818],"genre_scores_gemma":[0.9315216,0.0008260342,0.01933636,0.0004920465,0.00008704589,0.0001752001,0.0009208199,0.0001598483,0.04648106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009125017,"threshold_uncertainty_score":0.03052622,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1964721952","doi":"10.1039/c2gc16421c","title":"Magnetic copper–iron nanoparticles as simple heterogeneous catalysts for the azide–alkyne click reaction in water","year":2012,"lang":"en","type":"article","venue":"Green Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":200,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Alkyne; Click chemistry; Bimetallic strip; Azide; Catalysis; Copper; Nanoparticle; Chemistry; Heterogeneous catalysis; Combinatorial chemistry; Magnetic nanoparticles; Chemical engineering; Materials science; Nanotechnology; Organic chemistry","authors":[{"name":"Reuben Hudson","is_ca":true},{"name":"Chao‐Jun Li","is_ca":true},{"name":"Audrey Moores","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0173983750249189,"gpt":0.2605645262763893,"spread":0.2431661512514704,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003133209,0.0003313857,0.0002172658,0.0003130462,0.0001904885,0.0003501714,0.0003797996,0.0003749251,0.0007737675],"category_scores_gemma":[0.0002338636,0.0002802914,0.0001808513,0.0001233238,0.0002644886,0.0004434462,0.0002393147,0.0003854789,0.0003478004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004365306,"about_ca_system_score_gemma":0.0001645845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007064605,"about_ca_topic_score_gemma":0.00155848,"domain_scores_codex":[0.9998124,0.00003079584,0.00001276807,0.00004125618,0.00006787835,0.0000348906],"domain_scores_gemma":[0.9999517,0.00001309746,0.000008236841,0.00000702533,0.00001030425,0.00000972109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004690452,0.00003550879,0.00006834089,0.0000644009,0.000005529578,0.00008321214,0.00003424536,0.0003336657,0.9921926,0.0008574574,0.0001877616,0.006090329],"study_design_scores_gemma":[0.00001392596,0.00008200416,0.0001323261,0.000002381159,0.000006309482,0.00004892444,0.000006599045,0.002329124,0.9955586,0.00008617894,0.001728409,0.000005295866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489002,0.003485225,0.03670734,0.0003378268,0.0001330724,0.0001285924,0.0001180411,0.0004258913,0.009763869],"genre_scores_gemma":[0.987688,0.0006079525,0.007834336,0.00003763139,0.00001642925,0.00002220987,0.00007476577,0.00004035388,0.003678307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007737675,"threshold_uncertainty_score":0.003167272,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1992831737","doi":"10.1021/bc200281k","title":"Regenerative Biomaterials that “Click”: Simple, Aqueous-Based Protocols for Hydrogel Synthesis, Surface Immobilization, and 3D Patterning","year":2011,"lang":"en","type":"review","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":196,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Click chemistry; Chemistry; Self-healing hydrogels; Cycloaddition; Nanotechnology; Tissue engineering; Combinatorial chemistry; Organic chemistry; Catalysis; Biomedical engineering; Materials science","authors":[{"name":"Chelsea M. Nimmo","is_ca":true},{"name":"Molly S. Shoichet","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09989903966220802,"gpt":0.3455512762831465,"spread":0.2456522366209384,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003747999,0.0009049221,0.0006655517,0.001318129,0.0001653984,0.0005306557,0.0005221091,0.0006218271,0.001552792],"category_scores_gemma":[0.0001656196,0.0003593728,0.0002833364,0.0009415873,0.000333982,0.001001678,0.0004215992,0.0007623836,0.002051293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004467259,"about_ca_system_score_gemma":0.0004145492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003716692,"about_ca_topic_score_gemma":0.0007995794,"domain_scores_codex":[0.999848,0.00001478285,0.00001437705,0.00002669954,0.0000762795,0.00001976221],"domain_scores_gemma":[0.9999585,0.00001099895,0.000009520612,0.000003078699,0.00001056621,0.000007256825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007064691,0.0001503736,0.0001232691,0.006637183,0.00006566423,0.000611113,0.0001170943,0.001071396,0.2353657,0.01376812,0.01189019,0.7301292],"study_design_scores_gemma":[0.00002197233,0.0002217432,0.0005315646,0.0004430474,0.00003943013,0.002541909,0.00004097528,0.0003802234,0.1117553,0.001827887,0.8821464,0.00004951413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005432105,0.9733877,0.009624207,0.0003448784,0.0004694471,0.00005326211,0.00007764682,0.0001515595,0.01045924],"genre_scores_gemma":[0.01825055,0.9623604,0.005734633,0.0002868604,0.0001468354,0.00006356737,0.0001193434,0.00001477877,0.01302302],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001552792,"threshold_uncertainty_score":0.005194604,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2326126796","doi":"10.1021/ja512880g","title":"Peptide/Protein Stapling and Unstapling: Introduction of <i>s</i> -Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":187,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of General Medical Sciences; Beef Cattle Research Council; National Institutes of Health; National Science Foundation","keywords":"Tetrazine; Chemistry; Peptide; Thioredoxin; Bioorthogonal chemistry; Cysteine; Regeneration (biology); Biochemistry; Combinatorial chemistry; Cell biology; Organic chemistry; Click chemistry; Enzyme","authors":[{"name":"Stephen P. Brown","is_ca":false},{"name":"Amos B. Smith","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01295401462684275,"gpt":0.2402837996032213,"spread":0.2273297849763786,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002929301,0.0004751909,0.0002663105,0.000190968,0.0001676505,0.0002741866,0.0003620281,0.0003433442,0.00103908],"category_scores_gemma":[0.0002423269,0.0002519892,0.0002303801,0.0001939657,0.0004340982,0.0003657727,0.000405562,0.0007263885,0.0004403633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000286628,"about_ca_system_score_gemma":0.0003288293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003592558,"about_ca_topic_score_gemma":0.0007912121,"domain_scores_codex":[0.9997832,0.00002214779,0.00002344382,0.00006590427,0.00006824094,0.00003699257],"domain_scores_gemma":[0.9998221,0.00002484392,0.00007828137,0.00002923446,0.00002368357,0.00002179905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003268981,0.0000114986,0.00003455156,0.00003756278,0.000004068404,0.00004007852,0.00002191339,0.00004765947,0.9978282,0.0002938502,0.00005955985,0.001588401],"study_design_scores_gemma":[0.00000381543,0.00006613874,0.0001564709,0.000001009722,0.000002712127,0.00007132701,0.000003044445,0.0001398694,0.9986644,0.00001968864,0.0008683146,0.000003184684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9343902,0.001206964,0.05721354,0.0001597022,0.00008044919,0.0004073708,0.0003953081,0.0006824865,0.005463947],"genre_scores_gemma":[0.9510929,0.001506647,0.03931198,0.0001625292,0.00002330157,0.0003625243,0.0006468312,0.0001708094,0.006722418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103908,"threshold_uncertainty_score":0.003476083,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1990816094","doi":"10.1021/ja0738125","title":"Convergent Preparation and Photophysical Characterization of Dimaleimide Dansyl Fluorogens:  Elucidation of the Maleimide Fluorescence Quenching Mechanism","year":2007,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":179,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Maleimide; Photochemistry; Quenching (fluorescence); Photoinduced electron transfer; Electron transfer; Fluorophore; Fluorescence; Intersystem crossing; Flash photolysis; Chromophore; Excited state; Reaction rate constant; Kinetics; Polymer chemistry; Singlet state","authors":[{"name":"Julia Guy","is_ca":true},{"name":"Karine Caron","is_ca":true},{"name":"Stéphane Dufresne","is_ca":true},{"name":"Stephen W. Michnick","is_ca":true},{"name":"Skene","is_ca":true},{"name":"Jeffrey W. Keillor","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008103166632354131,"gpt":0.2487381979845777,"spread":0.2406350313522236,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003619857,0.0003660755,0.0002964544,0.0001342243,0.00009916266,0.0002894877,0.0002835015,0.0002708937,0.0005608091],"category_scores_gemma":[0.0004434976,0.0001315416,0.0001501539,0.0001517261,0.0002282343,0.0004998999,0.0001658653,0.0005728244,0.0002323288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003926447,"about_ca_system_score_gemma":0.0001665322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003145291,"about_ca_topic_score_gemma":0.0006081464,"domain_scores_codex":[0.9998899,0.00001359563,0.000007712527,0.00002336944,0.00005050588,0.00001483967],"domain_scores_gemma":[0.9997866,0.00005694194,0.00006633188,0.00002283849,0.00003959448,0.00002768818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001839624,0.00001292219,0.00006408034,0.00002085656,0.000001226144,0.0000209158,0.00001527987,0.0001003735,0.9987827,0.0001187915,0.000008170134,0.000836248],"study_design_scores_gemma":[0.000002397179,0.00002949217,0.0002149119,7.29552e-7,0.000001487349,0.00002159318,0.000003089284,0.0004923969,0.9988481,0.00001286274,0.0003715777,0.000001514927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748717,0.0006645102,0.02283664,0.00006971419,0.00001406036,0.00007078901,0.0001754958,0.00005125409,0.001245835],"genre_scores_gemma":[0.9704416,0.001451938,0.02421243,0.00004031368,0.00000928982,0.00006259047,0.0004729933,0.00006219128,0.003246656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005608091,"threshold_uncertainty_score":0.002848864,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2003985473","doi":"10.1039/b809870k","title":"Dendrimer design using CuI-catalyzed alkyne–azide “click-chemistry”","year":2008,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":170,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Click chemistry; Dendrimer; Alkyne; Cycloaddition; Combinatorial chemistry; Chemistry; Macromolecule; Azide; Dispersity; Nanomaterials; Triazole; Catalysis; Nanotechnology; Organic chemistry; Materials science","authors":[{"name":"Grégory Franc","is_ca":true},{"name":"Ashok Kakkar","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1592062895316391,"gpt":0.3203707435769021,"spread":0.161164454045263,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108762,0.0004435078,0.0002731773,0.0002322754,0.0002221938,0.0003946262,0.0004326618,0.0003351689,0.001216025],"category_scores_gemma":[0.0002066282,0.0001927171,0.0002293291,0.0001834523,0.0002245726,0.0003898143,0.0002159128,0.0003254082,0.0006571051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000616692,"about_ca_system_score_gemma":0.0003511903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004140245,"about_ca_topic_score_gemma":0.0007832223,"domain_scores_codex":[0.9998932,0.00001164415,0.00001128689,0.00003271079,0.00002181508,0.00002930191],"domain_scores_gemma":[0.9999161,0.00001055328,0.00002608091,0.000009589579,0.00001747694,0.00002012532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001387956,0.00006234222,0.0001744341,0.0001097931,0.00001510614,0.0002004659,0.00002929748,0.002006172,0.9849241,0.002225637,0.0003443072,0.009769503],"study_design_scores_gemma":[0.0000330749,0.0002005133,0.0001848569,0.000002826221,0.00001164933,0.0001397074,0.00000472098,0.002897711,0.9907584,0.0001175226,0.005637848,0.00001108954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8381265,0.002678275,0.1418151,0.0006108651,0.0003340853,0.0006517186,0.0005462514,0.001825912,0.01341135],"genre_scores_gemma":[0.9555024,0.001008833,0.03728216,0.00009104754,0.0000269929,0.0001269166,0.0003223733,0.00007209724,0.005567174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216025,"threshold_uncertainty_score":0.004474401,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2080720352","doi":"10.1002/chem.201103244","title":"The First Well‐Defined Silver(I)‐Complex‐Catalyzed Cycloaddition of Azides onto Terminal Alkynes at Room Temperature","year":2011,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":166,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cycloaddition; Alkyne; Azide; Combinatorial chemistry; Catalysis; Chemistry; Computer science; Click chemistry; Scheme (mathematics); Organic chemistry; Mathematics","authors":[{"name":"James McNulty","is_ca":true},{"name":"Kunal Keskar","is_ca":true},{"name":"Ramesh Vemula","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02178181710257334,"gpt":0.2167043819740014,"spread":0.194922564871428,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716589,0.0004780539,0.0002928595,0.0001551184,0.0001847321,0.0003972696,0.0004966664,0.0004719511,0.001537966],"category_scores_gemma":[0.0002262205,0.0002523101,0.0002887454,0.0001874534,0.0003829682,0.0005407623,0.0003099047,0.0005708677,0.0008259856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549008,"about_ca_system_score_gemma":0.0002775693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005092716,"about_ca_topic_score_gemma":0.0008511418,"domain_scores_codex":[0.9997676,0.00002763229,0.0000151493,0.00005799236,0.00005512832,0.00007648206],"domain_scores_gemma":[0.9999226,0.00001567546,0.00001998811,0.00001144945,0.00001198088,0.00001814113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001438677,0.00005526703,0.0001654478,0.0002601396,0.00001602093,0.000423749,0.00014771,0.0002546461,0.9837787,0.002407835,0.001075167,0.01127137],"study_design_scores_gemma":[0.00001249805,0.0002247873,0.0003530988,0.000005227048,0.00000810549,0.0002985623,0.00001172767,0.0004846418,0.9897289,0.0001258861,0.008730587,0.00001589978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8535007,0.008718795,0.1015683,0.0005214685,0.0006209351,0.0005912305,0.001101494,0.001807885,0.03156929],"genre_scores_gemma":[0.9734153,0.002567981,0.01442588,0.00009051284,0.00003363446,0.00007042676,0.000333619,0.00008999802,0.008972576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537966,"threshold_uncertainty_score":0.005145073,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2611967614","doi":"10.1021/jacs.7b00513","title":"Designing Peptide and Protein Modified Hydrogels: Selecting the Optimal Conjugation Strategy","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":154,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Self-healing hydrogels; Chemistry; Biomolecule; Peptide; Protein engineering; Click chemistry; Tissue engineering; Drug delivery; Extracellular matrix; Combinatorial chemistry; Amino acid; Nanotechnology; Biochemistry; Biophysics; Enzyme; Organic chemistry; Biomedical engineering","authors":[{"name":"Stephanie A. Fisher","is_ca":true},{"name":"Alexander E. G. Baker","is_ca":true},{"name":"Molly S. Shoichet","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02544018206183929,"gpt":0.2825497724724466,"spread":0.2571095904106073,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007356387,0.0008779261,0.0004152176,0.0004765145,0.0002172186,0.000473216,0.0003403323,0.0004939146,0.0006493711],"category_scores_gemma":[0.000499303,0.0003778866,0.0002258699,0.0003990457,0.0002719163,0.0007387365,0.0002711756,0.0003779428,0.000485249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000457643,"about_ca_system_score_gemma":0.0004636463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003174764,"about_ca_topic_score_gemma":0.0009548622,"domain_scores_codex":[0.9997148,0.00005493763,0.00004204909,0.0000718439,0.00006309614,0.00005333509],"domain_scores_gemma":[0.99978,0.00005065188,0.00006925067,0.00001236466,0.00003760719,0.00005008058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005380921,0.00005454005,0.0001590781,0.0001320598,0.000008228147,0.00009940768,0.00002949393,0.0008935113,0.9937244,0.0005568839,0.00006329165,0.004225432],"study_design_scores_gemma":[0.00003470989,0.0002175183,0.0003075066,0.00001245682,0.00001835037,0.0001130166,0.00001698243,0.003332947,0.9931383,0.0001467116,0.002642545,0.00001902885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9001015,0.004573551,0.08717781,0.0003635102,0.00008320354,0.001026734,0.0003757877,0.0002537953,0.00604405],"genre_scores_gemma":[0.866837,0.004973277,0.1248035,0.000317735,0.00003664605,0.0005805701,0.0002605834,0.0001130372,0.002077549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008779261,"threshold_uncertainty_score":0.003890514,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2133096153","doi":"10.3390/molecules20059263","title":"Recent Advances in Click Chemistry Applied to Dendrimer Synthesis","year":2015,"lang":"en","type":"review","venue":"Molecules","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":152,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Click chemistry; Dendrimer; Chemistry; Combinatorial chemistry; Organic chemistry; Nanotechnology; Polymer science; Materials science","authors":[{"name":"Mathieu Arseneault","is_ca":true},{"name":"Caroline Wafer","is_ca":true},{"name":"Jean‐François Morin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04239273565894362,"gpt":0.3401335946813825,"spread":0.2977408590224389,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007671429,0.001176643,0.0009259749,0.002272968,0.000327182,0.0008528498,0.0006651169,0.0008498993,0.004186206],"category_scores_gemma":[0.0008639811,0.0005930416,0.0006669988,0.002563643,0.0004911665,0.001781497,0.0008046876,0.001568938,0.003161105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006680724,"about_ca_system_score_gemma":0.0007859063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006157954,"about_ca_topic_score_gemma":0.0008014258,"domain_scores_codex":[0.9996351,0.00003826366,0.0000447191,0.00009356231,0.0001451221,0.00004327423],"domain_scores_gemma":[0.9996358,0.0001595186,0.00005656981,0.00002185376,0.00009649389,0.00002966398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009152121,0.0001620056,0.0002607087,0.03583158,0.0001178824,0.000634943,0.0002039945,0.001214783,0.0439494,0.01341255,0.02114642,0.8829742],"study_design_scores_gemma":[0.00001293381,0.0001608436,0.0003861214,0.001054261,0.00009751622,0.001406583,0.00003323219,0.0002320479,0.01998497,0.00179315,0.9747961,0.00004221174],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009410095,0.9902508,0.002067761,0.0002368518,0.0003818821,0.00002303006,0.00006204967,0.00005208172,0.005984465],"genre_scores_gemma":[0.004957424,0.991019,0.001230119,0.000217593,0.0001978396,0.00002454661,0.00007364219,0.000007641595,0.002272132],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004186206,"threshold_uncertainty_score":0.01400429,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2046246277","doi":"10.1021/ja045742x","title":"Synthesis and Characterization of Dimaleimide Fluorogens Designed for Specific Labeling of Proteins","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":149,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Maleimide; Chemistry; Fluorescence; Cysteine; Covalent bond; Thiol; Dithiol; Recombinant DNA; Regioselectivity; Combinatorial chemistry; Biochemistry; Enzyme; Organic chemistry","authors":[{"name":"Stéphane Girouard","is_ca":true},{"name":"Marie-Hélène Houle","is_ca":true},{"name":"Alain Grandbois","is_ca":true},{"name":"Jeffrey W. Keillor","is_ca":true},{"name":"Stephen W. Michnick","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0156377942258288,"gpt":0.2426181042733298,"spread":0.226980310047501,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003060531,0.0002941697,0.0002206108,0.0002165701,0.0001090988,0.0002299419,0.0001986053,0.0002420618,0.000819216],"category_scores_gemma":[0.000377984,0.0001378013,0.00009874191,0.0002084651,0.0001731209,0.0002254258,0.00009663098,0.0003001702,0.0003485805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003588432,"about_ca_system_score_gemma":0.0002306391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003816574,"about_ca_topic_score_gemma":0.0006917413,"domain_scores_codex":[0.9998949,0.00001390201,0.00000998842,0.00002189688,0.00003852673,0.00002083847],"domain_scores_gemma":[0.9997982,0.00004089751,0.00005059825,0.000023012,0.00003718966,0.00005001925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002467378,0.00001620722,0.0001204842,0.00002120164,0.000001377285,0.00003179848,0.000009102324,0.00008252131,0.9982511,0.0001292058,0.00001813358,0.001294175],"study_design_scores_gemma":[0.000003509994,0.0000470154,0.000509868,0.000001126638,0.000002976323,0.00006881965,0.000002586218,0.0001941289,0.9980053,0.0000102204,0.001152865,0.000001451301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963196,0.001425794,0.03177857,0.00008765733,0.00002416955,0.0002021212,0.0005852199,0.0001404184,0.002560014],"genre_scores_gemma":[0.9428335,0.002096647,0.04650772,0.00007666935,0.00001522127,0.0001403753,0.002113617,0.00008017824,0.00613619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000819216,"threshold_uncertainty_score":0.002740502,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2942127610","doi":"10.1021/jacs.8b11912","title":"Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":148,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Novartis Institutes for BioMedical Research; National Institutes of Health; Canadian Institute for Advanced Research; University of California Berkeley; Howard Hughes Medical Institute","keywords":"Bioconjugation; Chemistry; Histidine; Combinatorial chemistry; Click chemistry; Cysteine; Covalent bond; Reagent; Azide; Lysine; Bioorthogonal chemistry; Surface modification; Biochemistry; Amino acid; Organic chemistry; Enzyme","authors":[{"name":"Shang Jia","is_ca":false},{"name":"Dan He","is_ca":false},{"name":"Christopher J. Chang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00967685738337791,"gpt":0.2524968559738956,"spread":0.2428199985905177,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003453398,0.0004608211,0.00019817,0.0002088003,0.0001592441,0.0002459797,0.0003270186,0.0003858406,0.0007352554],"category_scores_gemma":[0.0002062729,0.0001847358,0.0001871705,0.0002206876,0.0002555923,0.0002785855,0.0002920731,0.0004663824,0.0003379831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003476796,"about_ca_system_score_gemma":0.0002015106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003226736,"about_ca_topic_score_gemma":0.0006961693,"domain_scores_codex":[0.9998087,0.00003743429,0.0000178425,0.00004289061,0.00006219804,0.00003084805],"domain_scores_gemma":[0.999904,0.00001667944,0.00003085255,0.00001675747,0.00001528329,0.00001635814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001611561,0.00001066734,0.00004783908,0.00003791666,0.000003649556,0.00005081005,0.00001052594,0.0001098749,0.997389,0.0004147401,0.00007459184,0.001834242],"study_design_scores_gemma":[0.000003550867,0.00005919749,0.0001722424,0.00000123056,0.000003529799,0.0001378138,0.000003146182,0.0004839502,0.9972879,0.00003833825,0.001805592,0.000003539139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9020408,0.004140238,0.08639005,0.0003241344,0.0001759862,0.0001230737,0.0004062706,0.0007754737,0.005623876],"genre_scores_gemma":[0.9657742,0.002264762,0.02882411,0.0001038247,0.0000271952,0.00004813185,0.000308822,0.00004684827,0.00260213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007352554,"threshold_uncertainty_score":0.002522588,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2049769716","doi":"10.1038/ncomms5612","title":"Copper nanoparticle heterogeneous catalytic ‘click’ cycloaddition confirmed by single-molecule spectroscopy","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":145,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nanomaterial-based catalyst; Catalysis; Heterogeneous catalysis; Nanoparticle; Homogeneous catalysis; Click chemistry; Molecule; Chemistry; Cycloaddition; Leaching (pedology); Chemical engineering; Materials science; Combinatorial chemistry; Nanotechnology; Organic chemistry","authors":[{"name":"Matthew R. Decan","is_ca":true},{"name":"Stefania Impellizzeri","is_ca":true},{"name":"M. Luisa Marín","is_ca":true},{"name":"J. C. Scaiano","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01274852477541241,"gpt":0.2739109200807732,"spread":0.2611623953053608,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004241295,0.0006006646,0.0004171394,0.0003216318,0.0004679682,0.000572315,0.0008565227,0.0007679917,0.004597166],"category_scores_gemma":[0.000528296,0.0003858138,0.000218614,0.0003579456,0.0008833458,0.0005916164,0.0003745718,0.000968678,0.0009050593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000639306,"about_ca_system_score_gemma":0.0002317485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001045116,"about_ca_topic_score_gemma":0.00164683,"domain_scores_codex":[0.9994028,0.00006108858,0.00001732757,0.0002129606,0.0001797388,0.0001261378],"domain_scores_gemma":[0.9997323,0.00008264447,0.00006946837,0.00004673248,0.00004575754,0.00002307041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001201136,0.0000379638,0.0001174236,0.00006128218,0.00001161641,0.0001894717,0.00006770941,0.0001383392,0.9952404,0.0008418709,0.0009853119,0.002188522],"study_design_scores_gemma":[0.00001410168,0.0000524451,0.0006563109,0.000002598699,0.000006104803,0.00008594472,0.00001870175,0.001601852,0.9960299,0.0001130849,0.001408756,0.00001023671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558414,0.0007554893,0.02255587,0.0005464879,0.0002551364,0.0000763389,0.0006434189,0.0007705902,0.01855543],"genre_scores_gemma":[0.992894,0.0002147973,0.003650559,0.00008663494,0.0000203833,0.00003321872,0.0001935874,0.00004843881,0.002858355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004597166,"threshold_uncertainty_score":0.01537901,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2154819382","doi":"10.1002/anie.200454235","title":"A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates","year":2004,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":143,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences","keywords":"Glycoside hydrolase; Chemistry; Azide; Covalent bond; Steric effects; Enzyme; Nucleophile; Adduct; Biochemistry; Stereochemistry; Catalysis; Organic chemistry","authors":[{"name":"David J. Vocadlo","is_ca":true},{"name":"Carolyn R. Bertozzi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02623290661982372,"gpt":0.2753976806172576,"spread":0.2491647739974338,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039967,0.001090359,0.0006152282,0.0006268088,0.0004029914,0.000536083,0.0007241119,0.000829085,0.001193628],"category_scores_gemma":[0.0003056737,0.0004873991,0.0005606117,0.0004041748,0.0002634738,0.0004428105,0.0005014634,0.001527063,0.002013553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003571204,"about_ca_system_score_gemma":0.0004225381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003538686,"about_ca_topic_score_gemma":0.000854875,"domain_scores_codex":[0.9996865,0.00004771745,0.00002654742,0.00008596828,0.0001028226,0.00005045777],"domain_scores_gemma":[0.9998241,0.00003327435,0.00002710924,0.00003965889,0.00003883701,0.00003712932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001789398,0.00001573473,0.00002506336,0.00002583273,0.00000479866,0.00001755168,0.000006086902,0.00001062,0.9984186,0.00008184095,0.00009716304,0.001278911],"study_design_scores_gemma":[0.000009152205,0.0000826194,0.0008839263,0.000004707307,0.00001279066,0.0004829757,0.000008586942,0.0007043267,0.992982,0.0001806538,0.004634626,0.00001358882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.334133,0.003755374,0.6446055,0.001209527,0.0004376912,0.0009198551,0.00733026,0.002596732,0.005012085],"genre_scores_gemma":[0.497882,0.006227686,0.4576083,0.001240303,0.0001333272,0.002201705,0.01443275,0.0003577039,0.01991624],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001193628,"threshold_uncertainty_score":0.003993154,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2040953161","doi":"10.1002/ejoc.201200930","title":"Discovery of a Robust and Efficient Homogeneous Silver(I) Catalyst for the Cycloaddition of Azides onto Terminal Alkynes","year":2012,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":143,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"McMaster University","keywords":"Cycloaddition; Chemistry; Catalysis; Homogeneous; Ligand (biochemistry); Homogeneous catalysis; Combinatorial chemistry; Terminal (telecommunication); Triazole; Click chemistry; Polymer chemistry; Organic chemistry; Receptor","authors":[{"name":"James McNulty","is_ca":true},{"name":"Kunal Keskar","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01370695659128132,"gpt":0.2188792979643795,"spread":0.2051723413730981,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889866,0.0003867663,0.0002516238,0.0002856868,0.0001074034,0.0005571837,0.0005054722,0.0003690071,0.0005910788],"category_scores_gemma":[0.0002297289,0.0002195461,0.0002937972,0.0001443565,0.0002180717,0.0002087053,0.0002775971,0.0003871114,0.0004757613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053625,"about_ca_system_score_gemma":0.0002477513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004923461,"about_ca_topic_score_gemma":0.0008995141,"domain_scores_codex":[0.9998037,0.0000160397,0.00001670192,0.00004618952,0.00006808522,0.00004932729],"domain_scores_gemma":[0.9998991,0.00001307988,0.00002487773,0.00001339871,0.00002165863,0.00002779067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003016682,0.00002237916,0.00008327531,0.00002701226,0.000006655715,0.00008159393,0.00001241565,0.0001408779,0.9969128,0.000333912,0.00007714594,0.00227178],"study_design_scores_gemma":[0.00001088391,0.00007158545,0.000178551,0.000001334087,0.00000687085,0.00007151075,0.00000326861,0.0008213613,0.9979784,0.00002402253,0.0008284975,0.000003772366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442443,0.00184172,0.04652308,0.00021874,0.0001023593,0.0001536366,0.0003446097,0.0005742562,0.005997244],"genre_scores_gemma":[0.9890563,0.0004631815,0.008142748,0.00002276059,0.00001246823,0.00002776506,0.0001945348,0.0000378404,0.002042339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005910788,"threshold_uncertainty_score":0.002941072,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2134954211","doi":"10.1002/chem.200800767","title":"Metal‐Catalyzed One‐Step Synthesis: Towards Direct Alternatives to Multistep Heterocycle and Amino Acid Derivative Formation","year":2008,"lang":"en","type":"review","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":139,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Combinatorial chemistry; Catalysis; Yield (engineering); Propargyl; Chemistry; Natural product; Derivative (finance); Transition metal; Reaction conditions; Organic chemistry; Materials science","authors":[{"name":"Bruce A. Arndtsen","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06386566804109947,"gpt":0.3003546461852936,"spread":0.2364889781441941,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004377353,0.0007085128,0.0006894342,0.0006683574,0.0002231154,0.0006143695,0.001059303,0.0007243865,0.002568541],"category_scores_gemma":[0.0002023053,0.0003006413,0.0002756762,0.0005809444,0.0005092929,0.001031453,0.0005756873,0.0008295884,0.002462697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006472024,"about_ca_system_score_gemma":0.0004813636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005190958,"about_ca_topic_score_gemma":0.0009592674,"domain_scores_codex":[0.9997954,0.0000238004,0.00001147549,0.00005206276,0.00008222805,0.00003509062],"domain_scores_gemma":[0.9999299,0.00002219574,0.00001583084,0.00000710861,0.00001339253,0.00001161226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001876821,0.000387122,0.0002035335,0.005567958,0.00007158879,0.00108667,0.0002209808,0.002061426,0.2737688,0.03256718,0.005492181,0.6783848],"study_design_scores_gemma":[0.0001299439,0.001020862,0.0008583738,0.0003486313,0.00008186205,0.004545944,0.00007553664,0.001913429,0.3194903,0.005012088,0.6664535,0.00006938378],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04456903,0.8642005,0.04956083,0.0006975859,0.0006351001,0.0003354095,0.0001300447,0.0004671273,0.03940427],"genre_scores_gemma":[0.1964254,0.7146229,0.04338902,0.0005793188,0.0003551694,0.0003260346,0.0001974072,0.00006020884,0.04404461],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002568541,"threshold_uncertainty_score":0.008592606,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1530222901","doi":"10.3390/antibiotics1010001","title":"Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs","year":2012,"lang":"en","type":"review","venue":"Antibiotics","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":134,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Antifungal; Interchangeability; Computational biology; Schematic; Tetracycline; Lipophilicity; Computer science; Chemistry; Biology; Antibiotics; Stereochemistry; Biochemistry; Microbiology; Engineering","authors":[{"name":"Domenico Fuoco","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05200553254785666,"gpt":0.3531061897989149,"spread":0.3011006572510582,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003931974,0.0007316529,0.0009723225,0.002708566,0.000330495,0.0009706957,0.000837813,0.0008018856,0.001683383],"category_scores_gemma":[0.0003338646,0.0003254846,0.0004605965,0.00190776,0.0007168883,0.001317682,0.0005083307,0.001467696,0.001262309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001623382,"about_ca_system_score_gemma":0.0009374396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445744,"about_ca_topic_score_gemma":0.002032491,"domain_scores_codex":[0.99977,0.00003675227,0.0000310716,0.0000505031,0.00008797093,0.00002371977],"domain_scores_gemma":[0.9998863,0.00003529156,0.00002456048,0.000006182564,0.00003726775,0.00001037338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005541623,0.0001641051,0.0003041502,0.009307414,0.00005624889,0.0005048695,0.0001693783,0.002824089,0.01758622,0.08897527,0.01477471,0.865278],"study_design_scores_gemma":[0.0000181753,0.0002013818,0.0008822172,0.001041697,0.00004364995,0.00167297,0.0000540523,0.001179187,0.007200276,0.0106858,0.9769862,0.00003439366],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001945871,0.9788579,0.006238148,0.00112979,0.0004771648,0.00007163525,0.0001042973,0.00005633364,0.01111875],"genre_scores_gemma":[0.01512957,0.9691576,0.007066967,0.0006750683,0.0004063289,0.000090075,0.0001660938,0.000008141576,0.007300071],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002708566,"threshold_uncertainty_score":0.01177847,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2128736891","doi":"10.1002/anie.201001240","title":"Enzymatic Site‐Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling","year":2010,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":131,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Methyltransferase; Click chemistry; Methylation; Surface modification; Chemistry; Methionine; Protein methylation; Enzyme; Posttranslational modification; Biochemistry; Combinatorial chemistry; Cofactor; Stereochemistry; Amino acid; DNA","authors":[{"name":"Wibke Peters","is_ca":false},{"name":"Sophie Willnow","is_ca":false},{"name":"Mike Duisken","is_ca":false},{"name":"H. O. Kleine","is_ca":false},{"name":"Thomas Macherey","is_ca":false},{"name":"Kelly Duncan","is_ca":true},{"name":"David W. Litchfield","is_ca":true},{"name":"Bernhard Lüscher","is_ca":false},{"name":"Elmar G. Weinhold","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01623051088160923,"gpt":0.2558334211838866,"spread":0.2396029103022773,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004253239,0.0005956895,0.0003610461,0.0001755396,0.0001473373,0.0002192706,0.0003676043,0.0005011934,0.001294985],"category_scores_gemma":[0.0003343815,0.0002276219,0.0003154597,0.0002552492,0.0001819683,0.0003381154,0.0002749942,0.0005661535,0.0006553986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003364258,"about_ca_system_score_gemma":0.0002697398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004791714,"about_ca_topic_score_gemma":0.0008193861,"domain_scores_codex":[0.9997938,0.00003699183,0.00001702741,0.00004537866,0.0000576167,0.0000492276],"domain_scores_gemma":[0.9998741,0.0000332583,0.0000287844,0.00002224252,0.00002166474,0.00001999774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003377129,0.00001074514,0.00004432612,0.00003979511,0.000004093579,0.00006540219,0.00001279577,0.00008546178,0.9981248,0.0003452675,0.00007987952,0.00115371],"study_design_scores_gemma":[0.000006488484,0.00006154987,0.0001946113,0.000001590701,0.000002599452,0.00007585087,0.000003284862,0.0004181216,0.9976251,0.00003418136,0.001573022,0.000003574407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8990837,0.001929045,0.09178551,0.0002909094,0.0001119206,0.0003128741,0.0008793948,0.0006033816,0.005003301],"genre_scores_gemma":[0.9608422,0.001774882,0.03161327,0.0000613739,0.00001585623,0.0001641802,0.0008979166,0.00008401532,0.004546323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294985,"threshold_uncertainty_score":0.004332125,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2888471281","doi":"10.1002/anie.201712611","title":"Boronic Acids as Bioorthogonal Probes for Site‐Selective Labeling of Proteins","year":2018,"lang":"en","type":"review","venue":"Angewandte Chemie International Edition","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":130,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Bioorthogonal chemistry; Boronic acid; Chemistry; Hydroxylamine; Combinatorial chemistry; Organic chemistry; Click chemistry","authors":[{"name":"Burcin Akgun","is_ca":true},{"name":"Dennis G. Hall","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04060367488934025,"gpt":0.343537979860337,"spread":0.3029343049709967,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005327737,0.0009827941,0.0007472753,0.001733638,0.0002121055,0.0005268676,0.0005811999,0.0008451806,0.001827993],"category_scores_gemma":[0.0002944943,0.0004019994,0.00041193,0.001375405,0.0003324379,0.000913922,0.0005144493,0.001416743,0.001735101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004836542,"about_ca_system_score_gemma":0.0004782663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006249448,"about_ca_topic_score_gemma":0.001131999,"domain_scores_codex":[0.999786,0.00002790117,0.0000163125,0.00003851861,0.00009381743,0.00003746273],"domain_scores_gemma":[0.9999232,0.00002365229,0.0000150629,0.000004281151,0.00002304642,0.00001076856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001284988,0.0001888928,0.0002441174,0.01826821,0.0001289834,0.0004549199,0.0001795232,0.001719272,0.1700338,0.01795886,0.01630805,0.7743869],"study_design_scores_gemma":[0.00002767722,0.0002513709,0.0006319073,0.001022993,0.0001072532,0.001147144,0.00005677313,0.0006318747,0.07923896,0.00271719,0.9141142,0.00005267539],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002262781,0.9895019,0.003233086,0.0001967109,0.0002847335,0.00002493722,0.00004004718,0.00005146059,0.004404388],"genre_scores_gemma":[0.01124849,0.9812952,0.00322284,0.0002272108,0.0001376477,0.00004030958,0.00009205841,0.000009292491,0.003726829],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001827993,"threshold_uncertainty_score":0.006115198,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2037098086","doi":"10.1039/b921630h","title":"Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes","year":2009,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":128,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Steacie Institute for Molecular Sciences; University of Ottawa","funders":"","keywords":"Strain (injury); Dipole; Chemistry; Stereochemistry; Computational chemistry; Photochemistry; Organic chemistry; Biology","authors":[{"name":"Craig S. McKay","is_ca":true},{"name":"Joseph Moran","is_ca":true},{"name":"John Paul Pezacki","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02370168104721405,"gpt":0.2888882031362979,"spread":0.2651865220890839,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003459995,0.0006255893,0.0002567909,0.0002103563,0.000151155,0.0003732608,0.0004214355,0.0002826017,0.002640382],"category_scores_gemma":[0.0002972256,0.0003063318,0.0002182568,0.00017152,0.0003705994,0.0005381323,0.0005306989,0.0007277025,0.0009998769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000341502,"about_ca_system_score_gemma":0.0001792664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003047457,"about_ca_topic_score_gemma":0.0008777488,"domain_scores_codex":[0.9998199,0.00002921464,0.00001210335,0.00003378077,0.0000509892,0.00005389643],"domain_scores_gemma":[0.999862,0.0000445947,0.00003068555,0.00001845001,0.00001327254,0.00003106337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403076,0.0000574906,0.0001118758,0.000122603,0.000009628206,0.0001666462,0.00008994479,0.0004655074,0.9914464,0.002585428,0.0003101727,0.004494125],"study_design_scores_gemma":[0.00005096508,0.0002244631,0.0003518019,0.000008300585,0.000007451121,0.000118287,0.0000260027,0.0004854068,0.9932082,0.0001835278,0.00532236,0.00001332602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603527,0.002284307,0.02063561,0.0002497468,0.0001968872,0.0003153966,0.0003711276,0.0003992283,0.01519501],"genre_scores_gemma":[0.9888738,0.001924408,0.004312292,0.00004884172,0.00002412425,0.0001025789,0.0001947781,0.00006525373,0.004453882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002640382,"threshold_uncertainty_score":0.008832991,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2122031992","doi":"10.1039/c4ob01758g","title":"Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives","year":2014,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":123,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ministry of Education and Child Care","funders":"","keywords":"Chemistry; Antifungal; Triazole; 1,2,4-Triazole; Combinatorial chemistry; Stereochemistry; Medicinal chemistry; Organic chemistry; Microbiology","authors":[{"name":"Zhicheng Dai","is_ca":true},{"name":"Yongfei Chen","is_ca":true},{"name":"Mao Zhang","is_ca":false},{"name":"Shengkun Li","is_ca":true},{"name":"Tingting Yang","is_ca":true},{"name":"Li Shen","is_ca":false},{"name":"Jianxin Wang","is_ca":true},{"name":"Shao‐Song Qian","is_ca":false},{"name":"Hai‐Liang Zhu","is_ca":false},{"name":"Yonghao Ye","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006680006869144797,"gpt":0.2195575715175281,"spread":0.2128775646483833,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497834,0.0004876656,0.0003555118,0.0003096017,0.0001651731,0.0001747668,0.000347494,0.0003110642,0.001551404],"category_scores_gemma":[0.0001146148,0.0001427873,0.0002477607,0.0003854978,0.0001644609,0.00019143,0.0001736408,0.0003809617,0.0004365624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729144,"about_ca_system_score_gemma":0.000316038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007713711,"about_ca_topic_score_gemma":0.001720175,"domain_scores_codex":[0.999915,0.00001509274,0.000007958612,0.00001579879,0.00002204734,0.00002410723],"domain_scores_gemma":[0.999948,0.000005944663,0.00001665331,0.000005415305,0.00001391027,0.00001001824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001635867,0.0001237215,0.0001887142,0.0003359555,0.00001906315,0.00036891,0.00004013882,0.001826582,0.9832116,0.0005640908,0.0004091168,0.01274839],"study_design_scores_gemma":[0.0001348495,0.00288526,0.002367072,0.00003220443,0.00007092665,0.0009140492,0.00003350159,0.002909442,0.9781497,0.0001651792,0.01230149,0.00003638565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396144,0.01861277,0.02754401,0.0005706953,0.0001462584,0.0005465958,0.002249603,0.000663683,0.0100519],"genre_scores_gemma":[0.9710565,0.009488922,0.01405379,0.0001364198,0.00002489169,0.0001925773,0.001088058,0.00001648384,0.003942399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551404,"threshold_uncertainty_score":0.005189896,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3121401699","doi":"10.1021/acs.chemrev.0c00832","title":"Bioorthogonal Reactions Utilizing Nitrones as Versatile Dipoles in Cycloaddition Reactions","year":2021,"lang":"en","type":"review","venue":"Chemical Reviews","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":122,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioorthogonal chemistry; Chemistry; Nitrone; Cycloaddition; Reactivity (psychology); Combinatorial chemistry; Organic chemistry; Click chemistry; Catalysis","authors":[{"name":"Didier A. Bilodeau","is_ca":true},{"name":"Kaitlyn D. Margison","is_ca":true},{"name":"Mariam Serhan","is_ca":true},{"name":"John Paul Pezacki","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1037268026868561,"gpt":0.3804798833948955,"spread":0.2767530807080393,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003605036,0.0008844457,0.0006779714,0.001487699,0.0002009239,0.0004974951,0.0005332123,0.0006191219,0.001848943],"category_scores_gemma":[0.0002235122,0.0004295693,0.0003920106,0.001181445,0.0003278361,0.0008124874,0.0005187792,0.001363371,0.001901969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004837771,"about_ca_system_score_gemma":0.0003335146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000428056,"about_ca_topic_score_gemma":0.0008501525,"domain_scores_codex":[0.9998288,0.0000196982,0.00001232258,0.00003304911,0.00007597791,0.00003019893],"domain_scores_gemma":[0.9999393,0.00002109293,0.00001152341,0.000003774868,0.00001652836,0.000007637356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001188057,0.0002677753,0.0002538412,0.01344006,0.0001056116,0.0005907906,0.0001385405,0.0017419,0.1453081,0.0183201,0.01529444,0.8044199],"study_design_scores_gemma":[0.00002855996,0.000257226,0.0006216869,0.000715415,0.00007124017,0.001377275,0.00003881095,0.0005165163,0.06467468,0.001834781,0.9298199,0.00004393959],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004759707,0.9796117,0.004175361,0.0002544126,0.0003935606,0.00005035121,0.0000651029,0.00009651012,0.01059327],"genre_scores_gemma":[0.01570085,0.975284,0.002552864,0.000214772,0.0001371495,0.00005662291,0.0001066081,0.000009740377,0.005937382],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001848943,"threshold_uncertainty_score":0.006185293,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1964140147","doi":"10.1194/jlr.d002790","title":"Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry","year":2009,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":117,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; Child and Family Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Welch Foundation; National Institutes of Health; Michael Smith Health Research BC; National Institute of General Medical Sciences; Cancer Research Institute","keywords":"Myristoylation; Chemistry; Acylation; Palmitoylation; Palmitic acid; Click chemistry; Omega 3 fatty acid; Biochemistry; Fatty acid; Biotinylation; Stereochemistry; Cysteine; Combinatorial chemistry; Polyunsaturated fatty acid; Docosahexaenoic acid; Enzyme; Membrane","authors":[{"name":"Megan C. Yap","is_ca":true},{"name":"Morris A. Kostiuk","is_ca":true},{"name":"Dale D. O. Martin","is_ca":true},{"name":"Maneka A. Perinpanayagam","is_ca":true},{"name":"Pieter G. Hak","is_ca":true},{"name":"Siddam Anjaiah","is_ca":false},{"name":"Janaki R. Majjigapu","is_ca":false},{"name":"Gurram Rajaiah","is_ca":false},{"name":"Bernd O. Keller","is_ca":true},{"name":"Jennifer A. Prescher","is_ca":false},{"name":"Peng Wu","is_ca":false},{"name":"Carolyn R. Bertozzi","is_ca":false},{"name":"John R. Falck","is_ca":false},{"name":"Luc G. Berthiaume","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05895030959874051,"gpt":0.3581738164830012,"spread":0.2992235068842607,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008267928,0.001068514,0.0004735058,0.0005377518,0.0002258345,0.0003476771,0.0005816039,0.000771377,0.00141399],"category_scores_gemma":[0.0003910717,0.0003980774,0.0005461044,0.0004728439,0.0005263692,0.0006388975,0.0005784064,0.0009817119,0.0009435657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002669725,"about_ca_system_score_gemma":0.0002280855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002215165,"about_ca_topic_score_gemma":0.0003867678,"domain_scores_codex":[0.9995133,0.00009406728,0.00003708013,0.0001414314,0.0001293574,0.00008483128],"domain_scores_gemma":[0.9997107,0.00009413183,0.00006773203,0.00003575445,0.00003842534,0.00005330264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002617674,0.00001087029,0.00003864744,0.00002855007,0.000004414664,0.00003829935,0.00001418948,0.0000323453,0.9983847,0.0001306024,0.00003599676,0.00125527],"study_design_scores_gemma":[0.000006858812,0.00009764428,0.0002865235,0.000002708934,0.000005143778,0.0001700198,0.000008281736,0.0007260291,0.9975884,0.00007033598,0.001032369,0.000005663349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6627855,0.002721955,0.3281572,0.0003488896,0.0001570751,0.0003123716,0.0004962738,0.001591658,0.003429007],"genre_scores_gemma":[0.8125915,0.004249273,0.172662,0.0002907618,0.00006996269,0.0005996082,0.001357121,0.0001622265,0.008017653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141399,"threshold_uncertainty_score":0.004730284,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2009441746","doi":"10.1021/jo202264r","title":"Sensitivities of Some Imidazole-1-sulfonyl Azide Salts","year":2012,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":113,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Sulfonyl; Azide; Reagent; Imidazole; Hydrochloride; Inorganic chemistry; Organic chemistry; Polymer chemistry; Alkyl","authors":[{"name":"N. Fischer","is_ca":false},{"name":"Ethan D. Goddard‐Borger","is_ca":true},{"name":"Robert Greiner","is_ca":false},{"name":"Thomas M. Klapötke","is_ca":false},{"name":"Brian W. Skelton","is_ca":false},{"name":"Jörg Stierstorfer","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01160197972126417,"gpt":0.230292238842225,"spread":0.2186902591209609,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004111982,0.000438955,0.0003278527,0.0003083804,0.0001607456,0.0002861938,0.0004511816,0.0004453426,0.0007696988],"category_scores_gemma":[0.0007279505,0.0001766217,0.0001870952,0.0002560047,0.0002875098,0.0002556474,0.0002905772,0.0003657382,0.0002200046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003952828,"about_ca_system_score_gemma":0.0001439633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000809896,"about_ca_topic_score_gemma":0.001071554,"domain_scores_codex":[0.9993937,0.0001142912,0.00006429252,0.0000910948,0.000263953,0.00007261048],"domain_scores_gemma":[0.9996165,0.00008884914,0.00008412774,0.00003370857,0.0001343636,0.0000423219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007170582,0.000005250021,0.0002466525,0.00002366148,0.000004688814,0.00003693867,0.00002659258,0.00008987528,0.9987263,0.00002994273,0.00001839246,0.0007200256],"study_design_scores_gemma":[0.000001844379,0.0001029316,0.0004631123,0.000001207617,0.000004804493,0.00004055788,0.00001353075,0.0003594494,0.998787,0.000006811683,0.0002159996,0.000002942392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935283,0.001215248,0.003825872,0.00006293004,0.00002583737,0.0000279712,0.0001222419,0.00007671871,0.001114845],"genre_scores_gemma":[0.9938555,0.0008289373,0.003734767,0.00002699388,0.000009406281,0.00001995977,0.0001807817,0.00001989091,0.001323784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000809896,"threshold_uncertainty_score":0.002867997,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1976699213","doi":"10.1021/jo049702n","title":"Mechanisms of Staudinger Reactions within Density Functional Theory","year":2004,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":113,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Transition state; Chemistry; Azide; Density functional theory; Phosphazene; Reaction mechanism; Staudinger reaction; Reaction intermediate; Computational chemistry; Photochemistry; Concerted reaction; Stepwise reaction; Stereochemistry; Catalysis; Kinetics; Organic chemistry; Reaction rate constant; Order of reaction","authors":[{"name":"Wei Quan Tian","is_ca":true},{"name":"Yan Alexander Wang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0137421621354244,"gpt":0.2219981023235073,"spread":0.2082559401880829,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00214906,0.001274496,0.002287564,0.00167085,0.001839084,0.002050993,0.003415769,0.002816319,0.00506509],"category_scores_gemma":[0.002615815,0.0008045308,0.002336381,0.001098581,0.001805074,0.002841045,0.001615643,0.00238417,0.0009511812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002381645,"about_ca_system_score_gemma":0.001976612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005130744,"about_ca_topic_score_gemma":0.002634874,"domain_scores_codex":[0.9991461,0.0003060721,0.00003805053,0.00007197608,0.0002583616,0.0001794488],"domain_scores_gemma":[0.9989913,0.0005702482,0.00008563284,0.0001294599,0.0001487815,0.00007455146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005508008,0.00006659302,0.0005949556,0.0003836102,0.00008141985,0.000276971,0.0002125493,0.2759939,0.002118862,0.7109984,0.001212539,0.008005095],"study_design_scores_gemma":[0.00003187019,0.00003707454,0.0001874659,0.00003068336,0.00001774011,0.00006356976,0.00003908524,0.8991738,0.0008491725,0.09852471,0.00101108,0.00003369464],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3513555,0.007112188,0.5624341,0.001564608,0.0004822133,0.000588871,0.001007955,0.001037091,0.07441761],"genre_scores_gemma":[0.8936448,0.00374403,0.08960611,0.0004992966,0.0001208113,0.001306698,0.0008463848,0.0002802726,0.009951564],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005130744,"threshold_uncertainty_score":0.01728004,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2092787687","doi":"10.2174/092986710790820615","title":"Click-Chemistry Reactions in Radiopharmaceutical Chemistry: Fast &amp; Easy Introduction of Radiolabels into Biomolecules for In Vivo Imaging","year":2010,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":112,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Bioconjugation; Chemistry; Click chemistry; Biomolecule; Combinatorial chemistry; In vivo; Radiochemistry; Biochemistry","authors":[{"name":"Carmen Wängler","is_ca":true},{"name":"Ralf Schirrmacher","is_ca":true},{"name":"Peter Bartenstein","is_ca":false},{"name":"Björn Wängler","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04771563166910767,"gpt":0.3954184207556827,"spread":0.347702789086575,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001696702,0.001875775,0.001008021,0.001342339,0.0005866575,0.001567623,0.001055808,0.002120801,0.004878995],"category_scores_gemma":[0.0008138422,0.0007980628,0.0008377878,0.00212071,0.001831725,0.002957592,0.001612876,0.003126199,0.006444673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008262001,"about_ca_system_score_gemma":0.0004094092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002211069,"about_ca_topic_score_gemma":0.0001613957,"domain_scores_codex":[0.9984277,0.0003430637,0.0001558589,0.0003576168,0.0005432124,0.0001726254],"domain_scores_gemma":[0.9996144,0.0001176455,0.0001010054,0.00005086857,0.00006794165,0.00004818138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003574877,0.0003367501,0.0003868669,0.005129855,0.0001036316,0.001358128,0.0005549015,0.002183539,0.5179565,0.1820004,0.02124237,0.2683896],"study_design_scores_gemma":[0.00004813735,0.0006083376,0.0003815981,0.0002181402,0.00005267845,0.002988572,0.00004464077,0.001605712,0.5608191,0.01178015,0.4213178,0.0001350745],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.0325983,0.3227128,0.5767006,0.002692206,0.005354797,0.0007753248,0.001090193,0.003517908,0.05455783],"genre_scores_gemma":[0.3046672,0.3160448,0.2767485,0.00420766,0.003306995,0.001624409,0.002983568,0.001185542,0.08923125],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004878995,"threshold_uncertainty_score":0.0163219,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4281670905","doi":"10.1002/cpz1.419","title":"A Comprehensive Guide for Assessing Covalent Inhibition in Enzymatic Assays Illustrated with Kinetic Simulations","year":2022,"lang":"en","type":"article","venue":"Current Protocols","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":111,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"European Federation of Pharmaceutical Industries and Associations; McGill University","keywords":"Covalent bond; Chemistry; Potency; Combinatorial chemistry; Biochemistry; Stereochemistry; In vitro; Organic chemistry","authors":[{"name":"Elma Mons","is_ca":false},{"name":"Sander Roet","is_ca":false},{"name":"Robbert Q. Kim","is_ca":false},{"name":"Monique P. C. Mulder","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09278013291664453,"gpt":0.392909636079831,"spread":0.3001295031631865,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003662363,0.003134561,0.002078682,0.002051364,0.001098896,0.002128117,0.004074119,0.0021143,0.06711421],"category_scores_gemma":[0.007733215,0.002377824,0.001867604,0.001802736,0.0006059192,0.001911712,0.001949379,0.005065554,0.03790686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001112179,"about_ca_system_score_gemma":0.002705815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002859924,"about_ca_topic_score_gemma":0.004233798,"domain_scores_codex":[0.9981782,0.0004184003,0.0002360362,0.0001990395,0.0008491762,0.0001191352],"domain_scores_gemma":[0.9963784,0.001751339,0.0001947758,0.0006030498,0.0009580536,0.0001144083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006067891,0.0008419034,0.002753152,0.00563639,0.0003980463,0.001120537,0.000818183,0.08959278,0.09810431,0.09436899,0.4625399,0.2432191],"study_design_scores_gemma":[0.000209923,0.0002249691,0.001164592,0.0007775029,0.00009066295,0.0004752329,0.0001324986,0.1925438,0.07401198,0.04750349,0.6825838,0.0002816487],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.005841816,0.002644176,0.8425259,0.0009001128,0.0007025519,0.001541737,0.05446862,0.06483561,0.02653945],"genre_scores_gemma":[0.02042221,0.005913564,0.8903461,0.0008209125,0.0001903439,0.009508727,0.03330583,0.01706054,0.02243186],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.06711421,"threshold_uncertainty_score":0.2245194,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2889516867","doi":"10.1016/j.ccr.2018.08.009","title":"Photoactivated platinum-based anticancer drugs","year":2018,"lang":"en","type":"article","venue":"Coordination Chemistry Reviews","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":110,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Higher Education Commision, Pakistan; The World Academy of Sciences","keywords":"Chemistry; Prodrug; Nedaplatin; Cisplatin; Combinatorial chemistry; Oxaliplatin; Platinum; Small molecule; Carboplatin; Drug; Organic chemistry; Pharmacology; Biochemistry; Cancer; Catalysis; Chemotherapy","authors":[{"name":"Muhammad Imran","is_ca":false},{"name":"Wagma Ayub","is_ca":false},{"name":"Ian S. Butler","is_ca":true},{"name":"Zia-Ur-Rehman","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02862045426573146,"gpt":0.3065951971037299,"spread":0.2779747428379984,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460558,0.0003372776,0.0002778728,0.0002203161,0.0001647814,0.0005232009,0.0004040809,0.0004988736,0.005866545],"category_scores_gemma":[0.0001574809,0.0001814778,0.0002331061,0.0002330992,0.0002469693,0.0005149264,0.0004179048,0.0007106223,0.001259382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005983296,"about_ca_system_score_gemma":0.0001407681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003946068,"about_ca_topic_score_gemma":0.0008023359,"domain_scores_codex":[0.9998788,0.00001463215,0.00000468184,0.00003238005,0.00003499699,0.00003446769],"domain_scores_gemma":[0.9999626,0.00001056573,0.00001108754,0.000004930189,0.000004294225,0.000006510277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002128597,0.00006910267,0.00007918279,0.0004927902,0.00003831056,0.0002744917,0.00007461739,0.000506138,0.946825,0.005355972,0.003524241,0.04254737],"study_design_scores_gemma":[0.00005135776,0.0003137954,0.0005466061,0.00002955013,0.00003536533,0.0003393112,0.00002712513,0.000890828,0.954733,0.0004979054,0.04251964,0.00001543196],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7270468,0.08367949,0.04316977,0.003012377,0.001653433,0.0003566812,0.0006606732,0.001526327,0.1388944],"genre_scores_gemma":[0.9268452,0.02421807,0.004442173,0.0006475431,0.000169909,0.00007198793,0.0002476038,0.00007745218,0.04327999],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005866545,"threshold_uncertainty_score":0.0196256,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2151567491","doi":"10.1002/chem.200903484","title":"Boronic Acid Catalysis for Mild and Selective [3+2] Dipolar Cycloadditions to Unsaturated Carboxylic Acids","year":2010,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":102,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Chemistry; Decarboxylation; Catalysis; Boronic acid; Carboxylic acid; Organic chemistry; Nitrile; Combinatorial chemistry","authors":[{"name":"Hongchao Zheng","is_ca":true},{"name":"Robert McDonald","is_ca":true},{"name":"Dennis G. Hall","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009057717021855538,"gpt":0.2349303539960888,"spread":0.2258726369742332,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003495572,0.0006443482,0.0002605824,0.0003659066,0.0002496751,0.0003653679,0.0003479724,0.0003926958,0.001049084],"category_scores_gemma":[0.0001783468,0.0002489741,0.000228393,0.000220501,0.0003524047,0.0004293137,0.0005025669,0.0006250902,0.000751543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003527581,"about_ca_system_score_gemma":0.0003022735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005202284,"about_ca_topic_score_gemma":0.001473377,"domain_scores_codex":[0.9997968,0.00003458402,0.00001642642,0.00003505194,0.00006529121,0.00005179279],"domain_scores_gemma":[0.9999456,0.000009763118,0.000013514,0.000006424511,0.00000889093,0.00001570189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009398316,0.00003345973,0.00008260058,0.0002031396,0.000009759508,0.0001516316,0.00005183526,0.0003187518,0.986699,0.002225965,0.0003257403,0.009804129],"study_design_scores_gemma":[0.00003211697,0.0002038964,0.0002743972,0.00001097518,0.00001491531,0.0002788021,0.00001669141,0.001114984,0.9895471,0.0003075073,0.008178319,0.00002045415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8164381,0.0165264,0.1379596,0.0007359626,0.0004624077,0.0004062642,0.0004249164,0.001034349,0.0260121],"genre_scores_gemma":[0.9741286,0.004277325,0.01778996,0.0001444063,0.00005328506,0.00007482919,0.0002129369,0.00004124868,0.003277344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049084,"threshold_uncertainty_score":0.003509521,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1975036143","doi":"10.1016/j.jim.2009.07.008","title":"EdU incorporation is an alternative non-radioactive assay to [3H]thymidine uptake for in vitro measurement of mice T-cell proliferations","year":2009,"lang":"en","type":"article","venue":"Journal of Immunological Methods","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":101,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Thymidine; In vitro; Molecular biology; Chemistry; Biology; Biochemistry","authors":[{"name":"Yongmao Yu","is_ca":true},{"name":"Alka Arora","is_ca":true},{"name":"Weixian Min","is_ca":true},{"name":"Chaim M. Roifman","is_ca":true},{"name":"Eyal Grunebaum","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0839988826042036,"gpt":0.3816591763178473,"spread":0.2976602937136438,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006505489,0.001227221,0.0006341889,0.001837509,0.0005118674,0.0007920649,0.0006924156,0.0008782219,0.004073698],"category_scores_gemma":[0.0004641776,0.000506465,0.0004298929,0.0009460024,0.0004166835,0.0007085203,0.0005108543,0.001845048,0.00115968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004008369,"about_ca_system_score_gemma":0.0002881671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004711973,"about_ca_topic_score_gemma":0.001618539,"domain_scores_codex":[0.9991165,0.0002203879,0.0000732686,0.0002004251,0.0002743021,0.0001151238],"domain_scores_gemma":[0.9993112,0.00023815,0.000128485,0.0001170891,0.0001153425,0.00008970212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009224728,0.00003961215,0.0001828555,0.00008492708,0.00001075195,0.00003195225,0.00003131422,0.00006079151,0.9936941,0.0005494264,0.0001112091,0.005110654],"study_design_scores_gemma":[0.000005275019,0.0001285978,0.0008070883,0.00000612859,0.00001988199,0.00007599277,0.000008347427,0.0005695529,0.9960848,0.00007355378,0.002213527,0.000007292359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6227028,0.00757964,0.341235,0.0002638838,0.0004468277,0.000299305,0.002120997,0.005041951,0.02030947],"genre_scores_gemma":[0.7208632,0.003858263,0.2285456,0.0001746873,0.0001402975,0.0006358589,0.005068202,0.0004323972,0.04028155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004073698,"threshold_uncertainty_score":0.01362789,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2115880913","doi":"10.1002/anie.201005705","title":"Self‐Immobilizing Fluorogenic Imaging Agents of Enzyme Activity","year":2010,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":100,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Enzyme; Fluorescence; In vivo; Cell sorting; Enzyme assay; Chemistry; Sorting; Biochemistry; Computer science; Staining; Cell; Information retrieval; Combinatorial chemistry; Computational biology; Biology; Biotechnology; Genetics","authors":[{"name":"David H. Kwan","is_ca":true},{"name":"Hong‐Ming Chen","is_ca":true},{"name":"Khakhanang Ratananikom","is_ca":false},{"name":"Susan M. Hancock","is_ca":true},{"name":"Yoichiro Watanabe","is_ca":true},{"name":"Prachumporn T. Kongsaeree","is_ca":false},{"name":"Lacey Samuels","is_ca":true},{"name":"Stephen G. Withers","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0131910793021605,"gpt":0.2752249535814796,"spread":0.2620338742793191,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000661454,0.0006525425,0.0004084413,0.000455399,0.0001700033,0.0005218257,0.0006412153,0.0006765476,0.002585179],"category_scores_gemma":[0.0004921809,0.0003688644,0.0003660889,0.0004195083,0.0003535257,0.0007371114,0.0004885491,0.001089198,0.001345876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004937334,"about_ca_system_score_gemma":0.0002868481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000383466,"about_ca_topic_score_gemma":0.0004587664,"domain_scores_codex":[0.999604,0.00006511013,0.00002435653,0.0001026693,0.0001228418,0.00008105374],"domain_scores_gemma":[0.9996451,0.00009668777,0.0000797013,0.00006717971,0.00006770442,0.00004362829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003151023,0.00001542056,0.00007348206,0.0001037956,0.000006363428,0.00003915464,0.00002400969,0.0000578853,0.9947683,0.0005494564,0.0002389558,0.004091666],"study_design_scores_gemma":[0.000003553513,0.00002779557,0.0001735003,0.000004500495,0.000005315609,0.000054898,0.000003473127,0.0002288028,0.9969798,0.00003488391,0.002480254,0.000003173115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7003913,0.01585149,0.2622631,0.0005821964,0.0003572313,0.000313095,0.001167462,0.002302434,0.01677172],"genre_scores_gemma":[0.8889629,0.007796072,0.07939115,0.0002734138,0.0001135189,0.0003320745,0.001391792,0.0002789391,0.0214601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002585179,"threshold_uncertainty_score":0.008648276,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2063509443","doi":"10.1016/j.cbpa.2014.05.023","title":"Strain-promoted cycloadditions involving nitrones and alkynes — rapid tunable reactions for bioorthogonal labeling","year":2014,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":99,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada","funders":"","keywords":"Bioorthogonal chemistry; Nitrone; Cycloaddition; Alkyne; Chemistry; Reactivity (psychology); Moiety; Combinatorial chemistry; Addition reaction; Click chemistry; Organic chemistry; Catalysis","authors":[{"name":"Douglas A. MacKenzie","is_ca":false},{"name":"Allison R. Sherratt","is_ca":true},{"name":"Mariya Chigrinova","is_ca":false},{"name":"Lawrence L. W. Cheung","is_ca":false},{"name":"John Paul Pezacki","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1330435185021089,"gpt":0.4093446380435753,"spread":0.2763011195414664,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005163368,0.0009913561,0.0007321931,0.0006113712,0.0001528327,0.0007122183,0.0009717108,0.0006246887,0.001679563],"category_scores_gemma":[0.0002602561,0.000433611,0.0003247462,0.0007083616,0.0004910673,0.001250857,0.00072713,0.002009378,0.001675303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005405897,"about_ca_system_score_gemma":0.0002982703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657835,"about_ca_topic_score_gemma":0.001476162,"domain_scores_codex":[0.999837,0.00001858198,0.0000101846,0.00003503858,0.00005600986,0.00004321458],"domain_scores_gemma":[0.9999365,0.00002137524,0.00001367381,0.000005726835,0.00001347834,0.00000927011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002061096,0.0002417065,0.0001764806,0.005831614,0.0001931554,0.0006426933,0.0001754021,0.00189383,0.2131917,0.02798882,0.01949165,0.7299668],"study_design_scores_gemma":[0.00008729962,0.0003507431,0.000688615,0.0004436663,0.0001393799,0.001092202,0.00006994528,0.001442227,0.1760737,0.003637084,0.8158963,0.00007884374],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01826139,0.9488636,0.01281183,0.0007318256,0.001319483,0.0000956684,0.0001537362,0.0002469727,0.01751553],"genre_scores_gemma":[0.07691722,0.9017122,0.005908308,0.0005416003,0.0003616041,0.00008660671,0.0002699377,0.00004064827,0.01416182],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001679563,"threshold_uncertainty_score":0.005618691,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2328827040","doi":"10.1021/ol401655r","title":"Copper-Catalyzed Tandem Azide–Alkyne Cycloaddition, Ullmann Type C–N Coupling, and Intramolecular Direct Arylation","year":2013,"lang":"en","type":"article","venue":"Organic Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":99,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Acadia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Cycloaddition; Intramolecular force; Alkyne; Tandem; Azide; Catalysis; Combinatorial chemistry; Copper; Triazole; Ligand (biochemistry); Stereochemistry; Organic chemistry; Receptor","authors":[{"name":"Kasiviswanadharaju Pericherla","is_ca":true},{"name":"Amitabh Jha","is_ca":true},{"name":"Bharti Khungar","is_ca":true},{"name":"Anil Kumar","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005853919002143835,"gpt":0.2030240550817835,"spread":0.1971701360796397,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003411521,0.0009592683,0.0007224221,0.0004479604,0.000411573,0.0003140254,0.0009151284,0.0003583106,0.001258062],"category_scores_gemma":[0.0002273365,0.0003622253,0.0004115081,0.0004994493,0.0003130196,0.000390645,0.0005288525,0.0008019999,0.0008665699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007839234,"about_ca_system_score_gemma":0.0007151316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001714027,"about_ca_topic_score_gemma":0.004620172,"domain_scores_codex":[0.9995857,0.00004492909,0.00003239116,0.00009764283,0.00009429362,0.0001450344],"domain_scores_gemma":[0.9999272,0.000009628955,0.00001595268,0.00001480377,0.00001271631,0.00001965395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049233,0.00009290563,0.0001764556,0.0002938758,0.0000418919,0.0006812492,0.00006955252,0.0007575129,0.9734738,0.001283315,0.0007999722,0.02222458],"study_design_scores_gemma":[0.00002311769,0.0001803967,0.0004811601,0.000005420634,0.00002281374,0.0005359118,0.0000100168,0.0009710945,0.9927403,0.00007400341,0.004937157,0.00001857337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7917035,0.01071024,0.1603883,0.0004849433,0.0004111434,0.001100947,0.000968038,0.003273113,0.0309598],"genre_scores_gemma":[0.9495379,0.00327176,0.03931302,0.00007198613,0.00004884534,0.0002447035,0.000454845,0.00005750818,0.006999383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714027,"threshold_uncertainty_score":0.005687773,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2015702758","doi":"10.1021/jo8008935","title":"Expeditive Synthesis of Glycodendrimer Scaffolds Based on Versatile TRIS and Mannoside Derivatives","year":2008,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":97,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Tris; Chemistry; Combinatorial chemistry; Computer science","authors":[{"name":"Yoann M. Chabre","is_ca":true},{"name":"Christine Contino-Pepin","is_ca":true},{"name":"Virginie Placide","is_ca":true},{"name":"Tze Chieh Shiao","is_ca":true},{"name":"René Roy","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01354493901025186,"gpt":0.2258294580116926,"spread":0.2122845190014407,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099553,0.0005272077,0.0002894783,0.0002087061,0.0001078016,0.0002772086,0.0002695837,0.0001772322,0.001086418],"category_scores_gemma":[0.00009798525,0.0001148414,0.0001706424,0.0002324611,0.0001433615,0.00024109,0.0002186076,0.000352819,0.0004015241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267109,"about_ca_system_score_gemma":0.0002212632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003934495,"about_ca_topic_score_gemma":0.0007974918,"domain_scores_codex":[0.9999282,0.000006762326,0.000006319986,0.00001664351,0.00001647652,0.00002555875],"domain_scores_gemma":[0.9999228,0.000008361644,0.00002633959,0.000007297594,0.000007738443,0.00002748322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009768048,0.00002712771,0.0001069965,0.00004515939,0.000008117995,0.0001655208,0.00002323039,0.0005193898,0.9918402,0.0005049696,0.0001121567,0.006549354],"study_design_scores_gemma":[0.00002593215,0.0004659241,0.0007880768,0.000003827999,0.00002098868,0.000212677,0.00001051833,0.0008777048,0.9932434,0.00005961417,0.004279158,0.00001217861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755493,0.002405052,0.01379214,0.0001059497,0.00006496494,0.00009398197,0.0006788166,0.0003697579,0.006939961],"genre_scores_gemma":[0.9836886,0.00175842,0.01101273,0.00004702284,0.00001442095,0.00004515377,0.0004997778,0.00003321631,0.002900623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086418,"threshold_uncertainty_score":0.003634393,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2525661400","doi":"10.1021/jacs.6b06922","title":"Heterogeneous Photocatalytic Click Chemistry","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":94,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre in Green Chemistry and Catalysis; University of Ottawa","funders":"Beijing University of Chemical Technology; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Chemistry; Cycloaddition; Catalysis; Photocatalysis; Copper; Alkyne; Click chemistry; Azide; Oxide; Copper oxide; Moisture; Semiconductor; Doping; Heterogeneous catalysis; Irradiation; Photochemistry; Chemical engineering; Combinatorial chemistry; Organic chemistry; Optoelectronics","authors":[{"name":"Bowen Wang","is_ca":true},{"name":"Javier E. Durantini","is_ca":true},{"name":"Jun Nie","is_ca":false},{"name":"Anabel E. Lanterna","is_ca":true},{"name":"J. C. Scaiano","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01049485873296166,"gpt":0.2531346628278699,"spread":0.2426398040949083,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001821313,0.0005462257,0.0002376668,0.0002818427,0.0001615452,0.0004547331,0.0004569832,0.0003000177,0.002645879],"category_scores_gemma":[0.0002223114,0.0001822374,0.0002583821,0.0003419143,0.0001861446,0.0003530363,0.0002995592,0.0004129001,0.0008257091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004980168,"about_ca_system_score_gemma":0.0001948977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005235333,"about_ca_topic_score_gemma":0.0009524262,"domain_scores_codex":[0.9997402,0.00002321035,0.0000181868,0.00007721805,0.000068477,0.00007258102],"domain_scores_gemma":[0.9999275,0.00001205917,0.00002139715,0.00001151622,0.00001180827,0.00001562091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008273798,0.00009356165,0.000294348,0.0001516055,0.00003899308,0.0002689463,0.00003396126,0.0004391058,0.9798104,0.003859164,0.001397742,0.01352942],"study_design_scores_gemma":[0.00001142086,0.0001157348,0.0003378522,0.000003330653,0.00001656229,0.0001602449,0.000007682499,0.0006078452,0.992143,0.0001259402,0.006462841,0.000007468984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8847209,0.006399536,0.0512393,0.0003252216,0.0005361525,0.0004575503,0.002064594,0.001953011,0.05230375],"genre_scores_gemma":[0.986711,0.001290421,0.00478366,0.00007953845,0.00002330645,0.00007782727,0.0005191883,0.00003878047,0.006476351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002645879,"threshold_uncertainty_score":0.008851349,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3165777761","doi":"10.1021/acs.jmedchem.1c00217","title":"Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors","year":2021,"lang":"en","type":"review","venue":"Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":94,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Structural Genomics Consortium; Wellcome Trust","keywords":"Chemistry; Linker; Drug discovery; Combinatorial chemistry; Ring (chemistry); Drug; Anticancer drug; Molecule; Small molecule; Stereochemistry; Organic chemistry; Biochemistry; Pharmacology","authors":[{"name":"Jennifer Alisa Amrhein","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Thomas Hanke","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1572009964291545,"gpt":0.3495176035082055,"spread":0.192316607079051,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006295905,0.0007444644,0.0008067998,0.001664811,0.0003139683,0.0009542321,0.0006460462,0.0008111378,0.003781392],"category_scores_gemma":[0.0005329984,0.0004489117,0.0005352653,0.001266175,0.0005183354,0.001961997,0.0006436154,0.001849204,0.002114547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004657755,"about_ca_system_score_gemma":0.000586284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004056267,"about_ca_topic_score_gemma":0.0009646225,"domain_scores_codex":[0.9996984,0.00003870645,0.00003233101,0.00006221283,0.0001248691,0.00004349352],"domain_scores_gemma":[0.9998192,0.00007500785,0.00003114139,0.000009780092,0.00004320656,0.00002163671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001151069,0.0001908369,0.0002450319,0.02349358,0.00008348582,0.000889799,0.0002202991,0.00186324,0.05251211,0.04313895,0.02687725,0.8503703],"study_design_scores_gemma":[0.00001563165,0.0002401342,0.0003330542,0.001067199,0.00004226619,0.001237031,0.0000489224,0.00034988,0.009712652,0.003496307,0.9834312,0.00002583193],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001683273,0.9910323,0.001676177,0.0004148043,0.0003322733,0.00002090229,0.0000554599,0.00003743897,0.004747341],"genre_scores_gemma":[0.009219494,0.9854853,0.001736784,0.0004368297,0.000323507,0.00002710709,0.00009603428,0.000009436277,0.00266549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003781392,"threshold_uncertainty_score":0.01264995,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2292831572","doi":"10.1039/c6sc00005c","title":"Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":93,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Deutsche Forschungsgemeinschaft","keywords":"Disulfide bond; Labelling; Chemistry; Cyclic peptide; Water soluble; Combinatorial chemistry; Dual (grammatical number); Peptide; Biochemistry; Organic chemistry","authors":[{"name":"Tao Wang","is_ca":false},{"name":"Andreas Riegger","is_ca":false},{"name":"Markus Lamla","is_ca":false},{"name":"Sebastian Wiese","is_ca":true},{"name":"Patrick Oeckl","is_ca":false},{"name":"Markus Otto","is_ca":false},{"name":"Yuzhou Wu","is_ca":false},{"name":"Stephan Fischer","is_ca":false},{"name":"Holger Barth","is_ca":false},{"name":"Seah Ling Kuan","is_ca":false},{"name":"Tanja Weil","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02276014958495073,"gpt":0.2526147192743073,"spread":0.2298545696893566,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003741279,0.0005911674,0.0001832512,0.0002277862,0.0001313604,0.0002431081,0.0002826783,0.0003656927,0.001530532],"category_scores_gemma":[0.0002129842,0.0002304061,0.000125835,0.0002270325,0.0003090739,0.0004535237,0.0003429851,0.0005262455,0.0005696496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002866441,"about_ca_system_score_gemma":0.0003177262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002825414,"about_ca_topic_score_gemma":0.001148324,"domain_scores_codex":[0.9998399,0.00003508375,0.00001212467,0.00002851729,0.00005061512,0.00003361965],"domain_scores_gemma":[0.9998959,0.00002480948,0.00002807465,0.000009732802,0.00001019982,0.0000311143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008530827,0.00001753718,0.00003917268,0.00008317831,0.000003086502,0.00006704792,0.00002744295,0.000147918,0.9943889,0.0007696497,0.0001806084,0.004190122],"study_design_scores_gemma":[0.00001787274,0.000117074,0.0001685364,0.000003514224,0.000005737669,0.00008540151,0.000006488871,0.00101892,0.9948381,0.00009168495,0.003640144,0.00000658672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9187484,0.007204701,0.06505042,0.0003998703,0.0002591818,0.0001168519,0.0003363666,0.0005498875,0.007334315],"genre_scores_gemma":[0.9658815,0.00318996,0.02112756,0.0001031161,0.00005543205,0.00007525721,0.0004027206,0.00007235675,0.009092178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530532,"threshold_uncertainty_score":0.005120099,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2598528124","doi":"10.1016/j.bbapap.2017.05.009","title":"Modeling covalent-modifier drugs","year":2017,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":92,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Compute Canada","keywords":"Covalent bond; Chemistry; Combinatorial chemistry; Electrophile; Drug discovery; Ligand (biochemistry); Selectivity; Reactivity (psychology); Docking (animal); Stereochemistry; Organic chemistry; Biochemistry; Receptor","authors":[{"name":"Ernest Awoonor‐Williams","is_ca":true},{"name":"Andrew G. Walsh","is_ca":true},{"name":"Christopher N. Rowley","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1025380644673491,"gpt":0.3626189811733639,"spread":0.2600809167060148,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001998219,0.000979717,0.0004856789,0.0002122358,0.0001364341,0.0004866563,0.000814995,0.0006096311,0.002195316],"category_scores_gemma":[0.0002232641,0.0001939034,0.0003547169,0.0002281051,0.0003297818,0.0009759909,0.0005294406,0.0006829922,0.001069692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004042502,"about_ca_system_score_gemma":0.0003129355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004135449,"about_ca_topic_score_gemma":0.0005215316,"domain_scores_codex":[0.999916,0.00001353745,0.000004194842,0.00001880285,0.00003340526,0.00001418016],"domain_scores_gemma":[0.999961,0.00001535919,0.000009741115,0.000005349136,0.000005136273,0.000003311442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002221649,0.0001922737,0.0004498651,0.006272998,0.0002034693,0.0006425279,0.00009942907,0.0431197,0.4231693,0.1174793,0.01601982,0.3921292],"study_design_scores_gemma":[0.0000719701,0.0004260545,0.0004336951,0.0002798067,0.0002024949,0.0008430949,0.00003715701,0.05910344,0.5155258,0.01807863,0.4049332,0.00006472682],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1191531,0.4799888,0.3468889,0.00199565,0.001832279,0.0003300004,0.0007277974,0.002861473,0.04622211],"genre_scores_gemma":[0.4976794,0.4000032,0.06263914,0.0007453762,0.000621484,0.0004021206,0.0009635366,0.0002198509,0.03672585],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002195316,"threshold_uncertainty_score":0.007344127,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}