{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":222,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":222,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"61311a98985e","filters":{"topic":"Pharmacological Receptor Mechanisms and Effects"}},"results":[{"id":"W3208556307","doi":"10.1016/s2214-109x(21)00448-4","title":"Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Global Health","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":400,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Impact; McMaster University","funders":"Rainwater Charitable Foundation; York University; McMaster University; University of Ottawa","keywords":"Medicine; Placebo; Randomized controlled trial; Clinical endpoint; Clinical trial; Emergency department; Intention-to-treat analysis; Internal medicine; Physical therapy; Emergency medicine; Psychiatry; Alternative medicine","authors":[{"name":"Gilmar Reis","is_ca":false},{"name":"Eduardo Augusto dos Santos Moreira-Silva","is_ca":false},{"name":"Daniela Carla Medeiros Silva","is_ca":false},{"name":"Lehana Thabane","is_ca":true},{"name":"Aline Cruz Milagres","is_ca":false},{"name":"Thiago Santiago Ferreira","is_ca":false},{"name":"Castilho Vitor Quirino dos Santos","is_ca":false},{"name":"Vitoria Helena de Souza Campos","is_ca":false},{"name":"Ana Maria Ribeiro Nogueira","is_ca":false},{"name":"Ana Paula Figueiredo Guimaraes Almeida","is_ca":false},{"name":"Eduardo Diniz Callegari","is_ca":false},{"name":"Adhemar Dias de Figueiredo Neto","is_ca":false},{"name":"Leonardo Cançado Monteiro Savassi","is_ca":false},{"name":"Maria Izabel Campos Simplicio","is_ca":false},{"name":"Luciene Barra Ribeiro","is_ca":false},{"name":"Rosemary Oliveira","is_ca":false},{"name":"Ofir Harari","is_ca":false},{"name":"Jamie I. Forrest","is_ca":false},{"name":"Hinda Ruton","is_ca":false},{"name":"Sheila Sprague","is_ca":true},{"name":"Paula McKay","is_ca":true},{"name":"А. В. Глущенко","is_ca":true},{"name":"Craig R. Rayner","is_ca":false},{"name":"Eric J. Lenze","is_ca":false},{"name":"Angela M. Reiersen","is_ca":false},{"name":"Gordon Guyatt","is_ca":true},{"name":"Edward J. Mills","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02732576398539328,"gpt":0.37523736797848,"spread":0.3479116039930867,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004570672,0.002309996,0.004113946,0.0004337202,0.0005223303,0.00155763,0.001039946,0.00322483,0.006271873],"category_scores_gemma":[0.007270111,0.0006798653,0.003476649,0.0003522352,0.001445414,0.001424658,0.001041894,0.002910848,0.0005483572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008115294,"about_ca_system_score_gemma":0.001577855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009095191,"about_ca_topic_score_gemma":0.001272287,"domain_scores_codex":[0.9962404,0.002704782,0.0001974822,0.0004356696,0.0001374422,0.000284267],"domain_scores_gemma":[0.9967973,0.00134001,0.0007815214,0.0003023704,0.0001658886,0.0006129647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9879563,0.002618952,0.0002973204,0.0006027695,0.0008221713,0.00001743171,0.00003264521,0.0001548592,0.0005402117,0.0001040086,0.0002890483,0.006564236],"study_design_scores_gemma":[0.9440547,0.05316633,0.001083061,0.00009385086,0.0005581668,0.00001640308,0.00001696701,0.0002756739,0.0001289614,0.0002400429,0.0003504213,0.00001543337],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973996,0.009006848,0.001095209,0.001662885,0.001377703,0.008603595,0.001116217,0.0001004052,0.003040974],"genre_scores_gemma":[0.9814191,0.001907574,0.00282319,0.001196894,0.00066163,0.009489061,0.000678142,0.00002006291,0.001804381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006271873,"threshold_uncertainty_score":0.02417237,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3200660426","doi":"10.1111/bph.15539","title":"THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels","year":2021,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":249,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Key (lock); Clinical pharmacology; Computer science; Section (typography); Computational biology; Pharmacology; Information retrieval; Medicine; Biology","authors":[{"name":"S P H Alexander","is_ca":false},{"name":"Alistair Mathie","is_ca":false},{"name":"John A. Peters","is_ca":false},{"name":"Emma L. Veale","is_ca":false},{"name":"Jörg Striessnig","is_ca":false},{"name":"Eamonn Kelly","is_ca":false},{"name":"Jane F Armstrong","is_ca":false},{"name":"Elena Faccenda","is_ca":false},{"name":"Simon D Harding","is_ca":false},{"name":"Adam J Pawson","is_ca":false},{"name":"Christopher Southan","is_ca":false},{"name":"Jamie A. Davies","is_ca":false},{"name":"Richard W. Aldrich","is_ca":false},{"name":"Bernard Attali","is_ca":false},{"name":"Austin M. Baggetta","is_ca":false},{"name":"Elvir Bećirović","is_ca":false},{"name":"Martin Biel","is_ca":false},{"name":"Roslyn M. Bill","is_ca":false},{"name":"William A. Catterall","is_ca":false},{"name":"Alex C. Conner","is_ca":false},{"name":"Paul Davies","is_ca":false},{"name":"Markus Delling","is_ca":false},{"name":"Francesco Di Virgilio","is_ca":false},{"name":"Simonetta Falzoni","is_ca":false},{"name":"Stefanie Fenske","is_ca":false},{"name":"Chandy George","is_ca":false},{"name":"Steven A. Goldstein","is_ca":false},{"name":"Stephan Grissmer","is_ca":false},{"name":"Kotdaji Ha","is_ca":false},{"name":"Verena Hammelmann","is_ca":false},{"name":"Israel Hanukoglu","is_ca":false},{"name":"Mike Jarvis","is_ca":false},{"name":"Anders A. Jensen","is_ca":false},{"name":"Leonard K. Kaczmarek","is_ca":false},{"name":"Stephan Kellenberger","is_ca":false},{"name":"Charles Kennedy","is_ca":false},{"name":"Brian King","is_ca":false},{"name":"Philip Kitchen","is_ca":false},{"name":"Joseph W. Lynch","is_ca":false},{"name":"Edward Perez‐Reyes","is_ca":false},{"name":"Leigh D. Plant","is_ca":false},{"name":"Lachlan D. Rash","is_ca":false},{"name":"Dejian Ren","is_ca":false},{"name":"Mootaz M. Salman","is_ca":false},{"name":"Lucia G. Sivilotti","is_ca":false},{"name":"Trevor G. Smart","is_ca":false},{"name":"Terrance P. Snutch","is_ca":true},{"name":"Jinbin Tian","is_ca":false},{"name":"James S. Trimmer","is_ca":false},{"name":"Charlotte Van den Eynde","is_ca":false},{"name":"Joris Vriens","is_ca":false},{"name":"Aguan Wei","is_ca":false},{"name":"Brenda T. Winn","is_ca":false},{"name":"Heike Wulff","is_ca":false},{"name":"Haoxing Xu","is_ca":false},{"name":"Lixia Yue","is_ca":false},{"name":"Xiaoli Zhang","is_ca":false},{"name":"Michael X. Zhu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009341213945938457,"gpt":0.3131688216506959,"spread":0.3038276077047574,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004169096,0.00180899,0.001948549,0.00364133,0.001047808,0.006823529,0.003865816,0.003887583,0.1292674],"category_scores_gemma":[0.01094947,0.001273125,0.001035956,0.003213385,0.001793399,0.005378151,0.003039246,0.007877884,0.2286927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00218497,"about_ca_system_score_gemma":0.007405408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002288512,"about_ca_topic_score_gemma":0.003498262,"domain_scores_codex":[0.9959941,0.000807935,0.0004923003,0.0003433661,0.002056789,0.0003055651],"domain_scores_gemma":[0.9928241,0.002122474,0.0005644758,0.0006003154,0.003062499,0.0008261875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002791023,0.00003418938,0.00003629129,0.0008104126,0.00000569679,0.00006437042,0.00006267787,0.0001778481,0.001011183,0.008731497,0.8504242,0.1386137],"study_design_scores_gemma":[0.000005297395,0.00002162365,0.00003688631,0.0002132444,0.000002117143,0.000134109,0.00001088208,0.00004070579,0.0001830352,0.001867362,0.9974762,0.000008535506],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.0009356171,0.2129114,0.112001,0.05409874,0.06552376,0.001561707,0.01511559,0.01936555,0.5184866],"genre_scores_gemma":[0.004429962,0.2214841,0.05968111,0.03183078,0.01464682,0.001550173,0.02007034,0.004815087,0.6414917],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1292674,"threshold_uncertainty_score":0.4324427,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1561309798","doi":"10.1113/jphysiol.2006.116178","title":"The sigma‐1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus","year":2006,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"NMDA receptor; Long-term potentiation; Neuroscience; Neurotransmission; Excitatory postsynaptic potential; Chemistry; Synaptic plasticity; Agonist; Postsynaptic potential; Hippocampus; Receptor; Biology; Inhibitory postsynaptic potential; Biochemistry","authors":[{"name":"Marzia Martina","is_ca":true},{"name":"Marie‐Eve B.‐Turcotte","is_ca":true},{"name":"Samantha Halman","is_ca":true},{"name":"Richard Bergeron","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006071968010250413,"gpt":0.2305481656980445,"spread":0.2244761976877941,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007617603,0.0002204863,0.0003579253,0.0001955516,0.0001035071,0.0001831115,0.0001333738,0.0001514452,0.0007932184],"category_scores_gemma":[0.0001517382,0.0001590526,0.0001813942,0.000152715,0.000221966,0.0002224902,0.0001099022,0.0003785204,0.0002969911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213404,"about_ca_system_score_gemma":0.0002355617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267829,"about_ca_topic_score_gemma":0.002321827,"domain_scores_codex":[0.9999275,0.000009105991,0.000006101423,0.00001001556,0.00001736626,0.00002987805],"domain_scores_gemma":[0.99993,0.000008115007,0.00002175142,0.000007026571,0.00001152374,0.00002160562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004190724,0.0000163104,0.0003261048,0.0000373057,0.000005576922,0.00008479138,0.00001986615,0.00002856225,0.9975102,0.00006438069,0.00002870222,0.001459078],"study_design_scores_gemma":[0.00008744971,0.001484368,0.02795615,0.00001881149,0.00007969879,0.0004849958,0.0001096494,0.0007362302,0.9679019,0.0002451134,0.0008796857,0.0000158806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970911,0.00154965,0.000564486,0.00009185509,0.0000139364,0.000005174405,0.000111631,0.00003727466,0.0005349918],"genre_scores_gemma":[0.9963036,0.001853031,0.0005994533,0.00004355405,0.00001262851,0.00001176878,0.0001666997,0.000009292748,0.001000076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001267829,"threshold_uncertainty_score":0.002653599,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2093109116","doi":"10.1254/jphs.crj04005x","title":"The Role of Sigma Receptors in Depression","year":2005,"lang":"en","type":"review","venue":"Journal of Pharmacological Sciences","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Serotonergic; Antidepressant; Glutamatergic; Neuroscience; Dorsal raphe nucleus; Neurotransmission; Receptor; Pharmacology; Mechanism of action; 5-HT receptor; Hippocampus; Psychology; Medicine; Serotonin; Chemistry; Glutamate receptor; Internal medicine; In vitro; Biochemistry","authors":[{"name":"Jordanna E. Bermack","is_ca":true},{"name":"Guy Debonnel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03899064662085815,"gpt":0.3958426116243988,"spread":0.3568519650035407,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004030241,0.0007654399,0.00120993,0.001508837,0.0003132277,0.0006582525,0.0008470765,0.001211068,0.001808116],"category_scores_gemma":[0.0003348741,0.0002691659,0.0003197872,0.001581769,0.0004387422,0.0008750891,0.0004992333,0.001124781,0.002042935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006346923,"about_ca_system_score_gemma":0.0007992685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001340709,"about_ca_topic_score_gemma":0.002184076,"domain_scores_codex":[0.9998608,0.00002569505,0.00002245617,0.00002314147,0.0000536842,0.00001429537],"domain_scores_gemma":[0.9998614,0.00004710657,0.00002370584,0.000005029619,0.00004378922,0.00001898169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009776842,0.00005714013,0.0003384051,0.008971748,0.00005685128,0.0006596216,0.00008002328,0.0004630328,0.005439565,0.003823126,0.0145671,0.9654457],"study_design_scores_gemma":[0.00003901035,0.0001857939,0.002286982,0.002653433,0.00009074512,0.004124735,0.0001322244,0.000148314,0.001589783,0.004344598,0.9843794,0.0000250538],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001978754,0.9984913,0.0001497838,0.0001747308,0.0001014323,0.00000310701,0.00000817881,0.000005808447,0.0008678003],"genre_scores_gemma":[0.0009667764,0.9981515,0.0001520505,0.00009865065,0.00009750087,0.000003862774,0.00001396214,5.653091e-7,0.0005151785],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001808116,"threshold_uncertainty_score":0.006048739,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2047823540","doi":"10.1152/jn.00321.2002","title":"Spreading Depression: Imaging and Blockade in the Rat Neocortical Brain Slice","year":2002,"lang":"en","type":"article","venue":"Journal of Neurophysiology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"","keywords":"Cortical spreading depression; NMDA receptor; CNQX; Neuroscience; Glutamate receptor; Chemistry; Anesthesia; Electrophysiology; Migraine; Pharmacology; Receptor; Medicine; Internal medicine; Psychology; AMPA receptor","authors":[{"name":"Trent Anderson","is_ca":true},{"name":"R. David Andrew","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01350091596302382,"gpt":0.265698817010617,"spread":0.2521979010475932,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003588021,0.0008945552,0.0003849443,0.0002838939,0.0002170039,0.0002459457,0.0008100453,0.0004736116,0.0008495836],"category_scores_gemma":[0.000121962,0.0003299693,0.0004830283,0.0002630597,0.0003131659,0.0003447179,0.0002797852,0.0009568566,0.0006296362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003557123,"about_ca_system_score_gemma":0.0004286718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003290941,"about_ca_topic_score_gemma":0.006472002,"domain_scores_codex":[0.9998618,0.0000167964,0.00001232325,0.00003789145,0.00003291184,0.00003827158],"domain_scores_gemma":[0.9998845,0.00001652783,0.00002525754,0.00001987464,0.00002794358,0.00002598869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000351689,0.00001554535,0.00002052258,0.0000281567,0.000003339657,0.00003375458,0.00001404245,0.00002990273,0.9990428,0.00004671923,0.00001413605,0.0007159476],"study_design_scores_gemma":[0.00002430455,0.0006442674,0.001419952,0.000008742925,0.00002739434,0.0002355621,0.00002106849,0.001326064,0.9953842,0.0000412819,0.0008628016,0.000004382748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8801551,0.006899017,0.1027156,0.0003677941,0.0001318185,0.0006036587,0.001331718,0.0007487527,0.007046577],"genre_scores_gemma":[0.8641163,0.00874634,0.1158954,0.0001482836,0.00004727967,0.0007420555,0.001460086,0.0001756311,0.008668643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003290941,"threshold_uncertainty_score":0.006543577,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2995628793","doi":"10.1124/pr.118.016311","title":"Imidazoline Receptor System: The Past, the Present, and the Future","year":2019,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Imidazoline receptor; Agmatine; Moxonidine; Rilmenidine; Clonidine; Receptor; Agonist; Chemistry; Pharmacology; Allosteric regulation; Stereochemistry; Biochemistry; Endocrinology; Medicine; Amino acid; Arginine","authors":[{"name":"Pascal Bousquet","is_ca":true},{"name":"Alan L. Hudson","is_ca":true},{"name":"Jesús A. Garcı́a-Sevilla","is_ca":true},{"name":"Jun‐Xu Li","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05844273434299099,"gpt":0.3711513324988874,"spread":0.3127085981558965,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004493831,0.0009248622,0.001333307,0.001287433,0.0002363286,0.001086811,0.001111016,0.0009805528,0.003814034],"category_scores_gemma":[0.0004447263,0.0002147921,0.0003055394,0.001654566,0.0005084237,0.00144144,0.0004985442,0.001762969,0.002378184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006063866,"about_ca_system_score_gemma":0.0009355222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077577,"about_ca_topic_score_gemma":0.00289221,"domain_scores_codex":[0.999887,0.00002154208,0.00001531517,0.00002507383,0.00003487793,0.00001622431],"domain_scores_gemma":[0.9998235,0.00007139039,0.0000326464,0.000005391623,0.00004006243,0.00002707339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001832416,0.00008043885,0.0001308768,0.01283098,0.00005927773,0.0002481484,0.00004447626,0.0003175261,0.004252963,0.004882349,0.03833964,0.93863],"study_design_scores_gemma":[0.00003776526,0.000136999,0.0007322698,0.002564671,0.0001299311,0.001207019,0.00008306714,0.0001410957,0.0005213493,0.002818592,0.9916025,0.00002466298],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005795786,0.9990366,0.00008119521,0.0001957785,0.000166353,0.000001348813,0.000008342116,0.000005298083,0.0004472447],"genre_scores_gemma":[0.0004289167,0.9986095,0.0001492461,0.000154936,0.0002045953,0.000002689824,0.00001336149,8.653071e-7,0.0004357292],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003814034,"threshold_uncertainty_score":0.01275927,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1695278265","doi":"10.3109/10799893.2015.1015737","title":"Sigma receptors [<b>σ</b>Rs]: biology in normal and diseased states","year":2015,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"University of Illinois at Urbana-Champaign","keywords":"Sigma-1 receptor; Receptor; Cell biology; Biology; Signal transduction; Sigma receptor; Biochemistry; Agonist","authors":[{"name":"Colin G. Rousseaux","is_ca":true},{"name":"Stephanie F. Greene","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01492741863982799,"gpt":0.2676790332421973,"spread":0.2527516146023693,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002299917,0.0005763164,0.0005607685,0.0006168023,0.000227022,0.0007803478,0.0003437237,0.000858478,0.002372553],"category_scores_gemma":[0.0002769735,0.0001345195,0.0003716146,0.0008568272,0.0003350472,0.0007915926,0.0003275228,0.0007884743,0.001354621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003598249,"about_ca_system_score_gemma":0.0005602914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007249612,"about_ca_topic_score_gemma":0.0008035937,"domain_scores_codex":[0.9998909,0.00002309646,0.0000212397,0.00001919168,0.00002863661,0.00001690331],"domain_scores_gemma":[0.9998788,0.0000309363,0.00002809785,0.000004252713,0.00003370179,0.00002418364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004685173,0.00004627311,0.00111041,0.008703474,0.0001776411,0.001010943,0.0001979794,0.0006356279,0.03198794,0.006437025,0.05841796,0.8908063],"study_design_scores_gemma":[0.00002426486,0.0004211248,0.003097097,0.001183098,0.0001207233,0.003087252,0.0001742727,0.000175395,0.003650114,0.003902492,0.9841312,0.0000330599],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002022188,0.991687,0.001173464,0.001079214,0.0009652709,0.00001093106,0.0001003048,0.00004768468,0.002914065],"genre_scores_gemma":[0.009690415,0.9840973,0.001028231,0.001228104,0.0008827335,0.00002150609,0.0001653654,0.000008785293,0.002877671],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002372553,"threshold_uncertainty_score":0.007937014,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2037506486","doi":"10.1523/jneurosci.0458-14.2014","title":"NMDA Receptors Are Upregulated and Trafficked to the Plasma Membrane after Sigma-1 Receptor Activation in the Rat Hippocampus","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Sigma-1 receptor; NMDA receptor; Chemistry; Sigma receptor; Receptor; Neuroscience; Agonist; Cell biology; Glutamate receptor; AMPA receptor; Hippocampus; Dendritic spine; Hippocampal formation; Biology; Biochemistry","authors":[{"name":"Mohan Pabba","is_ca":true},{"name":"Adrian Y. C. Wong","is_ca":true},{"name":"Nina Ahlskog","is_ca":true},{"name":"Elitza Hristova","is_ca":true},{"name":"Dante Biscaro","is_ca":true},{"name":"Wissam B. Nassrallah","is_ca":true},{"name":"Johnny K. Ngsee","is_ca":true},{"name":"Melissa A. Snyder","is_ca":true},{"name":"Jean-Claude Béı̈que","is_ca":true},{"name":"Richard Bergeron","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01085030413498471,"gpt":0.2468997521376125,"spread":0.2360494480026278,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008335245,0.0004471773,0.000553353,0.0003514724,0.0001751044,0.0002911693,0.0001737145,0.0003104216,0.001557931],"category_scores_gemma":[0.0001382637,0.0002725496,0.0003584792,0.0002222334,0.0003308049,0.0002858001,0.0002028403,0.0009553886,0.0004462224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003193552,"about_ca_system_score_gemma":0.000328866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408093,"about_ca_topic_score_gemma":0.00208958,"domain_scores_codex":[0.999858,0.000008582595,0.00001334702,0.00002452569,0.00004052246,0.00005496746],"domain_scores_gemma":[0.9998642,0.00000544406,0.00004741735,0.00001026492,0.00002132052,0.00005123499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006947158,0.00003494382,0.0005311072,0.00006672327,0.00001576777,0.0002167886,0.00004914731,0.00001523484,0.9971928,0.00003987536,0.00004613296,0.001096773],"study_design_scores_gemma":[0.00009214138,0.001336371,0.04929411,0.00002464309,0.00009111829,0.0009021468,0.0003834151,0.0003435321,0.946283,0.0001258531,0.001102814,0.00002083981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961365,0.002039092,0.0005450189,0.0001326606,0.0000561811,0.0000117522,0.0002893281,0.00006555852,0.0007239475],"genre_scores_gemma":[0.9931555,0.001942683,0.0006318734,0.00009663639,0.00003049703,0.00005239728,0.0004419072,0.00001721643,0.00363118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557931,"threshold_uncertainty_score":0.005211771,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2028079848","doi":"10.1152/jn.00654.2004","title":"Blocking the Anoxic Depolarization Protects Without Functional Compromise Following Simulated Stroke in Cortical Brain Slices","year":2004,"lang":"en","type":"article","venue":"Journal of Neurophysiology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"","keywords":"Cortical spreading depression; Depolarization; Neuroscience; Electrophysiology; Chemistry; Membrane potential; Glutamate receptor; NMDA receptor; Neuroprotection; AMPA receptor; Neocortex; Biophysics; Receptor; Biology; Anesthesia; Medicine","authors":[{"name":"Trent Anderson","is_ca":true},{"name":"Cathryn R. Jarvis","is_ca":true},{"name":"Alyson J. Biedermann","is_ca":true},{"name":"Christine Molnar","is_ca":true},{"name":"R. David Andrew","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01534202977040171,"gpt":0.2711457466677799,"spread":0.2558037168973782,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143264,0.000478721,0.0004186895,0.0001879244,0.0001971331,0.0003250535,0.0004481257,0.000278708,0.001107716],"category_scores_gemma":[0.00009675961,0.0002156301,0.0003018896,0.0002067171,0.0002670265,0.0002334657,0.0002100112,0.0006945046,0.0003614271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003847092,"about_ca_system_score_gemma":0.0005699726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004144665,"about_ca_topic_score_gemma":0.007212819,"domain_scores_codex":[0.9998686,0.0000100199,0.00002016574,0.00002329272,0.00002856525,0.00004927797],"domain_scores_gemma":[0.9999096,0.00001419375,0.00002387449,0.00001056034,0.00001587135,0.00002592483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001995563,0.00003875122,0.00006987009,0.00006838766,0.00001222742,0.00008900008,0.00003648079,0.00006723071,0.9986054,0.00008222093,0.00003550153,0.0006953016],"study_design_scores_gemma":[0.00003908002,0.0006961444,0.003909956,0.0000169784,0.00003918657,0.0002425931,0.00007953066,0.0006176927,0.9935164,0.00007531557,0.0007601744,0.000006948052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914992,0.002256508,0.002031137,0.0001169625,0.00004215571,0.00007315612,0.0009739936,0.00008470879,0.002922104],"genre_scores_gemma":[0.9904541,0.002853359,0.002592299,0.00007273802,0.00001161235,0.0001281366,0.001024267,0.0000258363,0.002837682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004144665,"threshold_uncertainty_score":0.008241117,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3128198726","doi":"10.1002/alz.12302","title":"Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Caprion (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Tolerability; Biomarker; Ex vivo; In vivo; Alzheimer's disease; Medicine; Pharmacology; Genetically modified mouse; Receptor; Pathology; Oncology; Internal medicine; Transgene; Chemistry; Disease; Biology; Biochemistry; Adverse effect","authors":[{"name":"Nicholas J. Izzo","is_ca":false},{"name":"Carla M. Yuede","is_ca":false},{"name":"Kelsie M. LaBarbera","is_ca":false},{"name":"Colleen S. Limegrover","is_ca":false},{"name":"Courtney Rehak","is_ca":false},{"name":"Raymond Yurko","is_ca":false},{"name":"Lora Waybright","is_ca":false},{"name":"Gary C. Look","is_ca":false},{"name":"Gilbert M. Rishton","is_ca":false},{"name":"Hank Safferstein","is_ca":false},{"name":"Mary E. Hamby","is_ca":false},{"name":"Claire Williams","is_ca":false},{"name":"Kelsey Sadlek","is_ca":false},{"name":"Hannah M. Edwards","is_ca":false},{"name":"Charles S. Davis","is_ca":false},{"name":"Michael Grundman","is_ca":false},{"name":"Lon S. Schneider","is_ca":false},{"name":"Steven T. DeKosky","is_ca":false},{"name":"Daniel Chelsky","is_ca":true},{"name":"Ian Pike","is_ca":false},{"name":"Christopher M. Henstridge","is_ca":false},{"name":"Kaj Blennow","is_ca":false},{"name":"Henrik Zetterberg","is_ca":false},{"name":"Harry LeVine","is_ca":false},{"name":"Tara L. Spires‐Jones","is_ca":false},{"name":"John R. Cirrito","is_ca":false},{"name":"Susan M. Catalano","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1582871649049838,"gpt":0.4133029228342438,"spread":0.25501575792926,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007556429,0.001094263,0.001004973,0.0005904084,0.0002444996,0.0006995645,0.0007420208,0.00109169,0.003743201],"category_scores_gemma":[0.0003501369,0.0002293199,0.0006606722,0.0004740962,0.0005498611,0.0005261048,0.000241357,0.001379363,0.0006371958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004624063,"about_ca_system_score_gemma":0.0008183636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000670392,"about_ca_topic_score_gemma":0.001722097,"domain_scores_codex":[0.9997887,0.00005996326,0.00002323114,0.00004459887,0.00004217711,0.00004134382],"domain_scores_gemma":[0.9997123,0.0000224392,0.00007687591,0.00002481129,0.00004975463,0.0001139175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1202191,0.03098506,0.003280058,0.002524717,0.0007647994,0.0007987866,0.0002542106,0.001524253,0.6304318,0.001369381,0.005222843,0.202625],"study_design_scores_gemma":[0.1106161,0.6339141,0.01785959,0.0003498744,0.001552677,0.001884049,0.0001465065,0.001647361,0.1933058,0.0006735361,0.03794016,0.0001102829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735891,0.01648901,0.002231376,0.0007391757,0.0002858351,0.002306829,0.001372475,0.0001582109,0.00282801],"genre_scores_gemma":[0.9746054,0.01137212,0.00390181,0.0005372053,0.0001897351,0.001829525,0.001349701,0.00003330677,0.00618127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003743201,"threshold_uncertainty_score":0.01252228,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3043525935","doi":"10.1186/s12916-020-01685-9","title":"Safety of psychotropic medications in people with COVID-19: evidence review and practical recommendations","year":2020,"lang":"en","type":"review","venue":"BMC Medicine","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Allergan; National Institutes of Health; Italfarmaco; Berlin Institute of Health; Servier; Medical Research Council; Gedeon Richter; King's College London; Department of Health and Social Care; Maudsley Charity; Sunovion; Mylan; South London and Maudsley NHS Foundation Trust; National Institute for Health and Care Research; Teva Pharmaceutical Industries; AstraZeneca; Eli Lilly and Company; H. Lundbeck A/S; Patient-Centered Outcomes Research Institute; Sanofi; National Institute of Mental Health; Pfizer","keywords":"Medicine; Context (archaeology); Psychotropic Agent; Psychotropic drug; Pandemic; Public health; Psychiatry; Medical emergency; MEDLINE; Coronavirus disease 2019 (COVID-19); Intensive care medicine; Disease; Drug; Nursing; Infectious disease (medical specialty)","authors":[{"name":"Giovanni Ostuzzi","is_ca":false},{"name":"Davide Papola","is_ca":false},{"name":"Chiara Gastaldon","is_ca":false},{"name":"Georgios Schoretsanitis","is_ca":false},{"name":"Federico Bertolini","is_ca":false},{"name":"Francesco Amaddeo","is_ca":false},{"name":"Alessandro Cuomo","is_ca":false},{"name":"Robin Emsley","is_ca":false},{"name":"Andrea Fagiolini","is_ca":false},{"name":"Giuseppe Imperadore","is_ca":false},{"name":"Taishiro Kishimoto","is_ca":false},{"name":"Giulia Michencigh","is_ca":false},{"name":"Michela Nosè","is_ca":false},{"name":"Marianna Purgato","is_ca":false},{"name":"Serdar Dursun","is_ca":true},{"name":"Brendon Stubbs","is_ca":false},{"name":"David Taylor","is_ca":false},{"name":"Graham Thornicroft","is_ca":false},{"name":"Philip B. Ward","is_ca":false},{"name":"Christoph Hiemke","is_ca":false},{"name":"Christoph U. Correll","is_ca":false},{"name":"Corrado Barbui","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1093213303207959,"gpt":0.4637217061263641,"spread":0.3544003758055682,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02082996,0.001884775,0.004153257,0.008520781,0.001338249,0.004179991,0.004535884,0.00677221,0.007378366],"category_scores_gemma":[0.07857096,0.001236345,0.007443051,0.004846033,0.001209182,0.004921259,0.002712192,0.005860514,0.001787197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00439845,"about_ca_system_score_gemma":0.02216092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008652138,"about_ca_topic_score_gemma":0.01686899,"domain_scores_codex":[0.9876781,0.004124914,0.004398196,0.0006994164,0.002672255,0.0004271473],"domain_scores_gemma":[0.9290046,0.04614022,0.009534481,0.001007027,0.01304181,0.001271935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003193156,0.0001921054,0.001685138,0.4346432,0.003303579,0.0003824551,0.0005761692,0.0007341826,0.0003398368,0.003576356,0.05602232,0.4982254],"study_design_scores_gemma":[0.0002478773,0.0001503436,0.002049906,0.8125141,0.00831214,0.0003024968,0.0004990526,0.0003432805,0.0002234054,0.004838232,0.1704491,0.00007014308],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006931657,0.9424407,0.00197042,0.04694688,0.003225231,0.001006132,0.0007019682,0.0000626332,0.002952785],"genre_scores_gemma":[0.008480511,0.9635695,0.01165309,0.01277124,0.001043634,0.001106173,0.0006185067,0.00001568777,0.0007416494],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02082996,"threshold_uncertainty_score":0.1101606,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2067388722","doi":"10.1016/s0891-0618(00)00106-x","title":"Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy","year":2000,"lang":"en","type":"article","venue":"Journal of Chemical Neuroanatomy","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Douglas Mental Health University Institute; McGill University","funders":"","keywords":"In situ hybridization; Sigma receptor; Receptor; Biology; Substantia nigra; Hippocampal formation; Sigma-1 receptor; Dentate gyrus; Neuroscience; NMDA receptor; Internal medicine; Messenger RNA; Agonist; Dopamine; Medicine; Genetics; Gene","authors":[{"name":"Kiyoyuki Kitaichi","is_ca":true},{"name":"Jean‐Guy Chabot","is_ca":true},{"name":"Fabian F. Moebius","is_ca":false},{"name":"Astrid Flandorfer","is_ca":false},{"name":"Hartmut Glossmann","is_ca":false},{"name":"Rémi Quirion","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02389234030396667,"gpt":0.2937095895672972,"spread":0.2698172492633306,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159685,0.0003503756,0.0002459152,0.0002642865,0.0001898225,0.0003245327,0.0003377382,0.0002636508,0.0009222768],"category_scores_gemma":[0.0001179406,0.0002067682,0.0002289197,0.0001179018,0.0003347783,0.0002603907,0.0001700698,0.000565536,0.0002585639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002701779,"about_ca_system_score_gemma":0.000252479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008554783,"about_ca_topic_score_gemma":0.001870145,"domain_scores_codex":[0.9999141,0.00001231057,0.00001154994,0.00002153484,0.0000172091,0.00002333133],"domain_scores_gemma":[0.9998726,0.00002423266,0.00004969811,0.0000138583,0.00001445641,0.00002516959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003939473,0.000003922485,0.00003525819,0.000009413106,0.000001583576,0.00002192145,0.000008824808,0.0000224197,0.999319,0.0002599157,0.000005651913,0.0002727694],"study_design_scores_gemma":[0.00001045386,0.000188023,0.001459489,0.000006581606,0.00002607894,0.0002774565,0.00003840934,0.0004356838,0.9961298,0.0001463375,0.001276579,0.000005178867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898301,0.001619098,0.006766241,0.0001815329,0.00003202481,0.00001850123,0.0002467316,0.00006278375,0.001242983],"genre_scores_gemma":[0.990932,0.001612507,0.004458979,0.00005863528,0.00001356182,0.00002390757,0.0003402541,0.00003173152,0.00252844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009222768,"threshold_uncertainty_score":0.003085256,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2023756943","doi":"10.1523/jneurosci.5618-10.2011","title":"Cocaine Hijacks σ1 Receptor to Initiate Induction of Activated Leukocyte Cell Adhesion Molecule: Implication for Increased Monocyte Adhesion and Migration in the CNS","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"National Center for Research Resources; National Institute on Drug Abuse; National Institute of Mental Health; National Institutes of Health","keywords":"ALCAM; Cell adhesion molecule; Cell biology; Cell adhesion; Downregulation and upregulation; Monocyte; Protein kinase B; Biology; Immunology; Signal transduction; Cell; Biochemistry","authors":[{"name":"Honghong Yao","is_ca":false},{"name":"Keejun Kim","is_ca":false},{"name":"Ming Duan","is_ca":false},{"name":"Teruo Hayashi","is_ca":false},{"name":"Ming‐Lei Guo","is_ca":false},{"name":"Susan Morgello","is_ca":false},{"name":"Alexander Prat","is_ca":true},{"name":"John Wang","is_ca":false},{"name":"Tsung‐Ping Su","is_ca":false},{"name":"Shilpa Buch","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04591752301731513,"gpt":0.2986455647111164,"spread":0.2527280416938013,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005997788,0.000231137,0.0001666623,0.0001568278,0.0001526207,0.0001709526,0.000105518,0.000217873,0.001434546],"category_scores_gemma":[0.00005921916,0.00008492224,0.0002184611,0.00008082268,0.0001103583,0.0001539101,0.0001598418,0.0003962793,0.0002264231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248233,"about_ca_system_score_gemma":0.0002103571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005712648,"about_ca_topic_score_gemma":0.001372494,"domain_scores_codex":[0.9999433,0.000006970113,0.000004499878,0.00001083789,0.00001216598,0.00002223551],"domain_scores_gemma":[0.9999667,0.000001879544,0.00001081412,0.000002625694,0.000004260544,0.00001355582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001242988,0.00004270344,0.0007106494,0.00005164673,0.000008806405,0.0002085721,0.00001402545,0.00002301561,0.9960593,0.0001325781,0.00006962226,0.002554844],"study_design_scores_gemma":[0.0000408411,0.001285622,0.0692087,0.00004127093,0.00006946311,0.003024182,0.0001111322,0.0009212817,0.920186,0.0003303509,0.004763485,0.00001776385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996022,0.002122094,0.0006160138,0.0001503152,0.00003413132,0.00001781377,0.0001376975,0.00002044062,0.0008795196],"genre_scores_gemma":[0.9944097,0.002443857,0.001030684,0.0001079761,0.00002327717,0.00003367547,0.000182524,0.000006154086,0.001762176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001434546,"threshold_uncertainty_score":0.004799008,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2127189084","doi":"10.1145/2491185.2491215","title":"FleXam","year":2013,"lang":"en","type":"article","venue":"","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Computer science","authors":[{"name":"Sajad Shirali-Shahreza","is_ca":true},{"name":"Yashar Ganjali","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006800317836501118,"gpt":0.2398580236248543,"spread":0.2330577057883532,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008269487,0.001372552,0.001548878,0.001431598,0.0007410562,0.002455961,0.00254231,0.002121071,0.8304538],"category_scores_gemma":[0.001792251,0.0006987176,0.0006955565,0.0008722246,0.0007779804,0.001234828,0.002542797,0.002130726,0.6753418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000627784,"about_ca_system_score_gemma":0.001045263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007658694,"about_ca_topic_score_gemma":0.0006793342,"domain_scores_codex":[0.9992105,0.00013333,0.00003544256,0.0001585515,0.00031364,0.0001485055],"domain_scores_gemma":[0.9991937,0.0001310335,0.0000523114,0.0001418653,0.0001288524,0.0003521805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003787598,0.0005266205,0.0003394138,0.004278484,0.0001317946,0.0009472753,0.0001038608,0.0003403741,0.04084956,0.01339306,0.5650951,0.3702068],"study_design_scores_gemma":[0.0002521203,0.0002970315,0.0006186516,0.0003309649,0.00003696572,0.0004814598,0.0000466566,0.000173084,0.004890517,0.001597152,0.9912611,0.00001437077],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.002868986,0.01335822,0.003518089,0.004507235,0.00414173,0.0004556596,0.01829893,0.003791838,0.9490593],"genre_scores_gemma":[0.03141492,0.008435897,0.002181052,0.001833467,0.000872674,0.0004091721,0.01850049,0.0008785377,0.9354738],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1695462,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1980297810","doi":"10.1038/sj.bjp.0704294","title":"Modulation of serotonergic neurotransmission by short‐ and long‐term treatments with sigma ligands","year":2001,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Sigma receptor; Serotonergic; Pentazocine; Pharmacology; Receptor; Chemistry; Sigma-1 receptor; 5-HT receptor; Serotonin; Agonist; Internal medicine; Medicine; Biochemistry; Analgesic","authors":[{"name":"Jordanna E. Bermack","is_ca":true},{"name":"Guy Debonnel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009351908377967495,"gpt":0.2773201455470919,"spread":0.2679682371691244,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008130668,0.0002509077,0.0003737735,0.00009711235,0.00009044023,0.0002259323,0.0002170447,0.0002518323,0.001004256],"category_scores_gemma":[0.0001868093,0.00009936796,0.0001939552,0.0001056486,0.000196414,0.0001368169,0.0001981228,0.0005354451,0.0002552577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002080622,"about_ca_system_score_gemma":0.0001704083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00049267,"about_ca_topic_score_gemma":0.001918342,"domain_scores_codex":[0.9998944,0.00002184085,0.00001358722,0.00001761725,0.00002188524,0.00003066969],"domain_scores_gemma":[0.999856,0.00002671937,0.00004303596,0.00001532384,0.00001591362,0.00004294007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001027678,0.00004793461,0.0003105234,0.00006744519,0.00002161726,0.0000688656,0.00002283621,0.0000359335,0.9958215,0.00003641436,0.0000455948,0.002493667],"study_design_scores_gemma":[0.0001767903,0.008847238,0.02797149,0.00003999058,0.0001263619,0.0005524253,0.000124338,0.0008270163,0.9580133,0.00007098861,0.003228831,0.00002126482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957559,0.002850776,0.0005817319,0.00005343577,0.00003200291,0.0000143728,0.0001588411,0.00002692511,0.0005259531],"genre_scores_gemma":[0.9948264,0.002427537,0.001000861,0.0000569918,0.00003386289,0.00005002443,0.0004126152,0.000007544231,0.001184009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004256,"threshold_uncertainty_score":0.003359556,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2218846395","doi":"10.1016/j.ijpharm.2015.12.055","title":"A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor","year":2015,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Irish Research Council; Fonds de Recherche du Québec - Santé; Irish Cancer Society","keywords":"Prostate cancer; Cyclodextrin; Chemistry; Cancer research; Receptor; Pharmacology; Sigma receptor; Cancer; Medicine; Internal medicine; Biochemistry","authors":[{"name":"Kathleen A. Fitzgerald","is_ca":false},{"name":"Meenakshi Malhotra","is_ca":false},{"name":"Matt Gooding","is_ca":false},{"name":"Florence Sallas","is_ca":false},{"name":"James Evans","is_ca":false},{"name":"Raphael Darcy","is_ca":false},{"name":"Caitríona M. O’Driscoll","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05101723768722837,"gpt":0.3683323166176241,"spread":0.3173150789303957,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009182649,0.0001952172,0.0001470091,0.0001172766,0.0001134258,0.0001812625,0.0001395013,0.0002454771,0.0003761952],"category_scores_gemma":[0.00006192287,0.00009397027,0.0001618316,0.00006344984,0.0001168761,0.0001548037,0.0001236319,0.0002131168,0.0001434988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003229869,"about_ca_system_score_gemma":0.0001676628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007446362,"about_ca_topic_score_gemma":0.001362392,"domain_scores_codex":[0.9999447,0.000004690113,0.000005270721,0.000015012,0.00001904836,0.00001134601],"domain_scores_gemma":[0.9999703,0.000005369528,0.00001023736,0.000002333804,0.000006160223,0.000005495887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001422823,0.000005151511,0.0000232309,0.00001745631,0.000001689071,0.00001066954,0.000003343092,0.00005126411,0.9986901,0.00004787404,0.00001959991,0.001115388],"study_design_scores_gemma":[0.000004944139,0.00006850246,0.0003884752,0.000001375044,0.0000069175,0.00004057456,0.000003348893,0.0007972842,0.9975706,0.000006502736,0.001108148,0.000003386391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781252,0.001669828,0.01733503,0.0001427181,0.00006574504,0.00007711645,0.0002219824,0.0001559841,0.002206367],"genre_scores_gemma":[0.9896036,0.0007605247,0.007045584,0.00007449231,0.000008774857,0.00004779736,0.0001458831,0.00001212933,0.002301258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007446362,"threshold_uncertainty_score":0.002343416,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2341426049","doi":"10.1021/acs.chemrestox.5b00305","title":"The Combination of Anti-CTLA-4 and PD1–/– Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury","year":2015,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Liver injury; Medicine; Immune system; Pharmacology; Isoniazid; Drug; Immunology; Pathology; Tuberculosis","authors":[{"name":"Alastair Mak","is_ca":true},{"name":"Jack Uetrecht","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06016126621871541,"gpt":0.3852826008648577,"spread":0.3251213346461423,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000424064,0.0009713003,0.0006866241,0.001179716,0.0002371303,0.000444783,0.0005643989,0.0009723253,0.002021113],"category_scores_gemma":[0.0002268467,0.0003770415,0.0006535174,0.0002278735,0.000594389,0.000512569,0.0002699104,0.00244699,0.0004071108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003553656,"about_ca_system_score_gemma":0.0002851545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000463279,"about_ca_topic_score_gemma":0.0009370008,"domain_scores_codex":[0.999374,0.0001226247,0.00006833945,0.000135208,0.0001646976,0.0001352017],"domain_scores_gemma":[0.9996043,0.00005080561,0.0001266314,0.0000606737,0.00002317658,0.0001344442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009433973,0.0007541318,0.0004314849,0.00008224077,0.00003812788,0.0002114237,0.00002776236,0.0001417447,0.9934105,0.0003068888,0.0001395197,0.003512719],"study_design_scores_gemma":[0.0003137389,0.01018976,0.004567501,0.00002302077,0.00008708785,0.001196545,0.00005309311,0.002103793,0.9775336,0.0002098376,0.00370201,0.00001997848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898679,0.001039878,0.004777414,0.0005906524,0.0001656466,0.0001893959,0.0005515997,0.0003137868,0.002503666],"genre_scores_gemma":[0.9873424,0.0009957235,0.006156015,0.0003424394,0.00007750757,0.0002441236,0.0004716922,0.00005644827,0.004313631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002021113,"threshold_uncertainty_score":0.006761253,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3209822455","doi":"10.1136/bmj-2021-068060","title":"Inhaled and intranasal ciclesonide for the treatment of covid-19 in adult outpatients: CONTAIN phase II randomised controlled trial","year":2021,"lang":"en","type":"article","venue":"BMJ","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true},"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre; University of British Columbia; McGill University Health Centre","funders":"McGill University Health Centre; Covis Pharma; McGill University; GlaxoSmithKline","keywords":"Medicine; Ciclesonide; Placebo; Interquartile range; Confidence interval; Population; Randomized controlled trial; Inhaler; Internal medicine; Physical therapy; Pediatrics; Anesthesia; Asthma","authors":[{"name":"Nicole Ezer","is_ca":true},{"name":"Sara Belga","is_ca":true},{"name":"Nick Daneman","is_ca":true},{"name":"Adrienne K. Chan","is_ca":true},{"name":"Benjamin M. Smith","is_ca":true},{"name":"Shay-Anne Daniels","is_ca":true},{"name":"Kristen Moran","is_ca":false},{"name":"Charlotte Besson","is_ca":true},{"name":"Louisa Y Smyth","is_ca":false},{"name":"Susan J. Bartlett","is_ca":true},{"name":"Andrea Benedetti","is_ca":true},{"name":"James G. Martin","is_ca":true},{"name":"Todd C. Lee","is_ca":true},{"name":"Emily G. McDonald","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02374057479648086,"gpt":0.3546050271583548,"spread":0.330864452361874,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001745963,0.001426651,0.004176911,0.0004125306,0.0005982866,0.001274482,0.001113014,0.002344257,0.007812443],"category_scores_gemma":[0.002387595,0.0006698993,0.001723223,0.0006856028,0.001060571,0.0006016065,0.000368991,0.001965676,0.0008476247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001855361,"about_ca_system_score_gemma":0.003641181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01071239,"about_ca_topic_score_gemma":0.02763751,"domain_scores_codex":[0.9991328,0.0003642348,0.00006951694,0.0001615698,0.0001074224,0.0001643967],"domain_scores_gemma":[0.9988335,0.0002582128,0.0002892773,0.00006164194,0.0001381991,0.0004191602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9815275,0.003381331,0.0005010367,0.002135199,0.0007626586,0.00004470242,0.00003990099,0.00009318811,0.001294638,0.00004957899,0.0007519372,0.009418197],"study_design_scores_gemma":[0.9813119,0.01690192,0.0009730359,0.00006724578,0.000228396,0.00001177956,0.00001146623,0.00006149652,0.00005412195,0.0000149287,0.0003590175,0.00000476601],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9208737,0.02522474,0.001297453,0.00146846,0.001815292,0.0399489,0.004942779,0.0002246561,0.004203999],"genre_scores_gemma":[0.932346,0.01510495,0.003392064,0.002521605,0.001280062,0.03713243,0.002931417,0.00003224382,0.00525922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01071239,"threshold_uncertainty_score":0.02613521,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2420761013","doi":"10.1371/journal.pone.0157021","title":"Pharmacological Investigations of the Dissociative ‘Legal Highs’ Diphenidine, Methoxphenidine and Analogues","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute on Drug Abuse; National Institute of Mental Health; Medical Research Council; National Institutes of Health","keywords":"Pharmacology; Reuptake; Dopamine; Norepinephrine transporter; Chemistry; Reuptake inhibitor; Norepinephrine; Opioid; Phencyclidine; Serotonin; NMDA receptor; Internal medicine; Medicine; Receptor; Biochemistry","authors":[{"name":"Jason Wallach","is_ca":false},{"name":"Heather Kang","is_ca":false},{"name":"Tristan Colestock","is_ca":false},{"name":"Hamilton Morris","is_ca":false},{"name":"Zuner A. Bortolotto","is_ca":false},{"name":"Graham L. Collingridge","is_ca":true},{"name":"David Lodge","is_ca":false},{"name":"Adam L. Halberstadt","is_ca":false},{"name":"Simon D. Brandt","is_ca":false},{"name":"Adeboye Adejare","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04042946017301361,"gpt":0.2662902801594966,"spread":0.225860819986483,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166126,0.0001881545,0.0001876161,0.0001252444,0.0001361756,0.0001739489,0.0001900908,0.0003099771,0.003342211],"category_scores_gemma":[0.0002743623,0.0001270939,0.0001456676,0.0001458489,0.0003213416,0.0002986749,0.000149914,0.0005154961,0.0003440636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208549,"about_ca_system_score_gemma":0.0001370451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000682671,"about_ca_topic_score_gemma":0.001422194,"domain_scores_codex":[0.9999136,0.00002296001,0.000005739706,0.00001555279,0.00002053361,0.00002167328],"domain_scores_gemma":[0.9998732,0.00003788927,0.00003473094,0.00001319698,0.00001809089,0.00002296208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009320519,0.0001569938,0.0005402819,0.000390705,0.00001865627,0.0002418662,0.0001329979,0.00005125664,0.9821349,0.0007771774,0.0001695212,0.01445355],"study_design_scores_gemma":[0.0003463122,0.02256318,0.06072329,0.0001059863,0.00009522532,0.004113966,0.0007267692,0.0009672957,0.8867348,0.0005551979,0.02303934,0.00002861447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987611,0.004976945,0.0007098561,0.0001983944,0.00002762912,0.00005857592,0.0001827565,0.00001045511,0.006224297],"genre_scores_gemma":[0.9885114,0.005775583,0.001877334,0.0002099655,0.00004620259,0.000041037,0.0003243804,0.000004279764,0.003209739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003342211,"threshold_uncertainty_score":0.01118082,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1598400473","doi":"10.1186/1744-8069-1-1","title":"Molecular Pain, a New Era of Pain Research and Medicine","year":2005,"lang":"en","type":"editorial","venue":"Molecular Pain","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Pain medicine; Medicine; Neuroscience; Chronic pain; Molecular biomarkers; Bioinformatics; Psychology; Psychiatry; Biology; Internal medicine","authors":[{"name":"Jianguo G. Gu","is_ca":false},{"name":"Min Zhuo","is_ca":true},{"name":"Michael J. Caterina","is_ca":false},{"name":"Amy B. MacDermott","is_ca":false},{"name":"Annika B. Malmberg","is_ca":false},{"name":"Volker Neugebauer","is_ca":false},{"name":"Megumu Yoshimura","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01658863589029229,"gpt":0.337713903948353,"spread":0.3211252680580607,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003546557,0.002414308,0.001664346,0.001912559,0.00157242,0.00532968,0.00180475,0.005286311,0.005028669],"category_scores_gemma":[0.009470792,0.0005390401,0.001102814,0.0007429803,0.003015398,0.004207197,0.0008726885,0.01586288,0.003354783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001470982,"about_ca_system_score_gemma":0.001708272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004877483,"about_ca_topic_score_gemma":0.001173339,"domain_scores_codex":[0.9976643,0.0004696097,0.0002605671,0.0002587203,0.001238544,0.0001082186],"domain_scores_gemma":[0.9896311,0.004787689,0.0005251871,0.0003117077,0.003369218,0.001375062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005917818,0.00002031859,0.00005175606,0.0006441451,0.00002954064,0.0002481804,0.00007144251,0.00004465461,0.0003011763,0.003185913,0.9687334,0.02661039],"study_design_scores_gemma":[0.00002493863,0.00004551312,0.0001968622,0.0002925486,0.00002886516,0.0006278032,0.00007325566,0.0001223742,0.0001250874,0.003604644,0.9948463,0.0000117815],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00007987123,0.03438291,0.000349631,0.03457305,0.9287856,0.000009965377,0.00001164728,0.00004953862,0.001757731],"genre_scores_gemma":[0.0009574028,0.02856178,0.0003383001,0.01777378,0.9449958,0.00001161714,0.0000130264,0.00001946493,0.007328701],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.00532968,"threshold_uncertainty_score":0.01875615,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3012249945","doi":"10.1096/fj.201901921r","title":"Sigma‐1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Junta de Andalucía","keywords":"SNi; Neuropathic pain; Nerve injury; Dorsal root ganglion; Peripheral nerve injury; Medicine; Sciatic nerve; ATF3; Neuroinflammation; Sciatic nerve injury; Neuroscience; Anesthesia; Anatomy; Internal medicine; Inflammation; Chemistry; Biology; Dorsum; Gene expression","authors":[{"name":"Inmaculada Bravo‐Caparrós","is_ca":false},{"name":"M. Carmen Ruiz‐Cantero","is_ca":false},{"name":"Gloria Perazzoli","is_ca":false},{"name":"Shane J. Cronin","is_ca":false},{"name":"José Miguel Vela","is_ca":false},{"name":"Mohamed F. Hamed","is_ca":false},{"name":"Josef Penninger","is_ca":true},{"name":"José M. Baeyens","is_ca":false},{"name":"Enrique J. Cobos","is_ca":false},{"name":"Francisco R. Nieto","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006668041311617499,"gpt":0.2306093633286278,"spread":0.2239413220170103,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799971,0.0004556685,0.0005277739,0.0002954268,0.0001576643,0.0003669084,0.0002001785,0.0004800558,0.001295477],"category_scores_gemma":[0.0001370126,0.0002139622,0.0004185644,0.0001730905,0.0005763024,0.0002952644,0.0002771536,0.0009369565,0.0003266605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267716,"about_ca_system_score_gemma":0.000327743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006693845,"about_ca_topic_score_gemma":0.0008886711,"domain_scores_codex":[0.9997533,0.00003889166,0.00002614008,0.00004046153,0.000045543,0.00009575322],"domain_scores_gemma":[0.9998243,0.000006731537,0.00007056532,0.000009790519,0.00002143583,0.00006718329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007381954,0.00005227996,0.0005883179,0.0001215184,0.000007849391,0.0001121817,0.0000320867,0.00004239748,0.9960813,0.0000875487,0.00006353712,0.00207275],"study_design_scores_gemma":[0.000194259,0.002325088,0.0932139,0.000106426,0.0001490278,0.0008984451,0.0004791282,0.001611997,0.8977587,0.0004858493,0.002734651,0.00004251207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899555,0.005795176,0.002195748,0.0002019711,0.00004950487,0.00003659563,0.0003241286,0.0001293356,0.001312015],"genre_scores_gemma":[0.9937931,0.002463606,0.0009352552,0.000103441,0.00001874475,0.00006583484,0.0002416054,0.00001802022,0.002360378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295477,"threshold_uncertainty_score":0.004333794,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4229043634","doi":"10.1080/15548627.2022.2063003","title":"Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine","year":2022,"lang":"en","type":"article","venue":"Autophagy","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute on Drug Abuse; National Institutes of Health; Johns Hopkins University; U.S. Department of Health and Human Services","keywords":"TFEB; Sigma-1 receptor; Biology; Autophagy; TARDBP; C9orf72; Karyopherin; Cell biology; Nuclear transport; Frontotemporal lobar degeneration; Amyotrophic lateral sclerosis; Parkin; Frontotemporal dementia; SOD1; Biochemistry; Cell nucleus; Trinucleotide repeat expansion; Parkinson's disease; Receptor; Nucleus; Medicine; Pathology","authors":[{"name":"Shao‐Ming Wang","is_ca":false},{"name":"Hsiang-En Wu","is_ca":false},{"name":"Yuko Yasui","is_ca":false},{"name":"Michal Geva","is_ca":false},{"name":"Michael R. Hayden","is_ca":true},{"name":"Tangui Maurice","is_ca":false},{"name":"Mauro Cozzolino","is_ca":false},{"name":"Tsung‐Ping Su","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007395112417740309,"gpt":0.2352599445594066,"spread":0.2278648321416663,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008725861,0.0002039446,0.0001946048,0.0000904706,0.0001153498,0.0002048645,0.000138629,0.0002331041,0.001163397],"category_scores_gemma":[0.00007595211,0.00008513906,0.0002007004,0.00005489592,0.0001332616,0.0001401154,0.000206208,0.0003941827,0.0003510229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203789,"about_ca_system_score_gemma":0.0001333941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003379095,"about_ca_topic_score_gemma":0.0005579973,"domain_scores_codex":[0.999931,0.000012455,0.000007493376,0.00001474285,0.00001585682,0.00001840515],"domain_scores_gemma":[0.9999374,0.000008454468,0.00002199491,0.000005432291,0.000006903456,0.00001973866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001236117,0.00001012626,0.00005889735,0.000019509,0.000002373244,0.0000479943,0.000005717039,0.00002500193,0.9992243,0.00005780286,0.00002750462,0.0003971468],"study_design_scores_gemma":[0.00001714777,0.0001830963,0.002318539,0.000004777129,0.000006875563,0.0002296715,0.00001926821,0.0007253358,0.9949678,0.00003460626,0.001489296,0.000003597729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957639,0.0008967713,0.001654555,0.0001055925,0.00002361355,0.00001467235,0.0002277383,0.00007607428,0.001237044],"genre_scores_gemma":[0.9963871,0.0004854602,0.001220103,0.00005228205,0.000007182323,0.00001525912,0.0004115855,0.000015215,0.001405835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163397,"threshold_uncertainty_score":0.003891945,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2946645772","doi":"10.1016/j.nbd.2019.05.009","title":"Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor","year":2019,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health; Teva Pharmaceutical Industries; National Institute for Health and Care Research; Johns Hopkins University","keywords":"Huntingtin; Sigma-1 receptor; Neuroprotection; Sigma receptor; Pharmacology; Huntingtin Protein; Agonist; Chemistry; Receptor; Biology; Neuroscience; Mutant; Biochemistry","authors":[{"name":"Chelsy R. Eddings","is_ca":false},{"name":"Nicolas Arbez","is_ca":false},{"name":"Sergey Akimov","is_ca":false},{"name":"Michal Geva","is_ca":false},{"name":"Michael R. Hayden","is_ca":true},{"name":"Christopher A. Ross","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0071763999777189,"gpt":0.2298694170411586,"spread":0.2226930170634397,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000911708,0.0002609765,0.0003200703,0.0001671605,0.0001555249,0.0002290168,0.000257496,0.0002644528,0.0007931903],"category_scores_gemma":[0.0001156249,0.0001214514,0.0001574801,0.00009761548,0.0001732449,0.0001809396,0.0001121031,0.0005184418,0.0001753479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000256564,"about_ca_system_score_gemma":0.0003048202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068707,"about_ca_topic_score_gemma":0.002628039,"domain_scores_codex":[0.9999473,0.000008624766,0.000006349092,0.000008266874,0.000008656581,0.00002077751],"domain_scores_gemma":[0.9999042,0.00001450816,0.00002701596,0.00001470332,0.00001208654,0.00002751071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001081239,0.0000507265,0.0003325081,0.00003871274,0.00001762269,0.00009693606,0.00002063042,0.00005939444,0.9960824,0.0001052289,0.0000587065,0.002055991],"study_design_scores_gemma":[0.0001859444,0.003501813,0.01372667,0.00001871905,0.00006010278,0.0003649949,0.00009300186,0.000819704,0.9800349,0.0002243356,0.0009565406,0.00001320192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978231,0.0009933002,0.0004464172,0.00007265009,0.00001870004,0.000005700916,0.0001254813,0.00005137885,0.0004633431],"genre_scores_gemma":[0.9971846,0.001048216,0.0004326316,0.00003487644,0.00000912206,0.000008591705,0.0001999939,0.00001011088,0.001071805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068707,"threshold_uncertainty_score":0.00265348,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2777237974","doi":"10.1016/j.jalz.2017.11.009","title":"AF710B, an M1/sigma‐1 receptor agonist with long‐lasting disease‐modifying properties in a transgenic rat model of Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true},"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Israel Institute for Biological Research; Merck Canada; Alzheimer's Society; Consortium canadien en neurodégénérescence associée au vieillissement; McGill University","keywords":"Neuroinflammation; Agonist; Neuropathology; Medicine; Sigma-1 receptor; Pharmacology; Genetically modified mouse; Endocrinology; Disease; Internal medicine; Cognitive decline; Receptor; Neuroscience; Psychology; Transgene; Dementia; Chemistry","authors":[{"name":"Hélène Hall","is_ca":true},{"name":"M. Florencia Iulita","is_ca":true},{"name":"Palma Gubert","is_ca":true},{"name":"Lisi Flores Aguilar","is_ca":true},{"name":"Adriana Ducatenzeiler","is_ca":true},{"name":"Abraham Fisher","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05419240417989615,"gpt":0.2903878932548724,"spread":0.2361954890749763,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000417238,0.001009868,0.0006462966,0.0006477374,0.0003526764,0.0003031861,0.0004677972,0.0006712369,0.00179604],"category_scores_gemma":[0.00009187518,0.0003170765,0.0004582821,0.0002908788,0.0003751683,0.0004022862,0.0001732986,0.001245476,0.0007858037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003831312,"about_ca_system_score_gemma":0.0005578984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247659,"about_ca_topic_score_gemma":0.002350245,"domain_scores_codex":[0.9998218,0.00002706673,0.00001939234,0.00002663745,0.00004133049,0.00006366766],"domain_scores_gemma":[0.9998358,0.00001003377,0.00004684089,0.00001570873,0.0000261087,0.00006549157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001111949,0.0003744073,0.0001566829,0.00006652508,0.00001159377,0.0000910353,0.0000226568,0.0000288686,0.995599,0.00006703477,0.0001233153,0.002346849],"study_design_scores_gemma":[0.00044683,0.01107114,0.005995791,0.00003208239,0.00009979124,0.0007073657,0.00006141327,0.0004501568,0.9787755,0.0001010105,0.002241598,0.00001736803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913849,0.003555849,0.002173396,0.000329313,0.00009743889,0.00007737659,0.0006929041,0.0003016918,0.001387182],"genre_scores_gemma":[0.9820118,0.004567968,0.004530168,0.0001864533,0.00006176771,0.0002512092,0.001246342,0.00005405277,0.007090295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179604,"threshold_uncertainty_score":0.006008327,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3152217306","doi":"10.1007/s13311-021-01022-9","title":"The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models","year":2021,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Fundação Luso-Americana para o Desenvolvimento; Universidade de Coimbra; Fundação para a Ciência e a Tecnologia; Karolinska Institutet; Fundo Regional para a Ciência e Tecnologia","keywords":"Sigma-1 receptor; Mitochondrion; Neuroprotection; Cell biology; Biology; Inositol trisphosphate receptor; Endoplasmic reticulum; Pharmacology; Chemistry; Receptor; Inositol; Agonist; Biochemistry","authors":[{"name":"Luana Naia","is_ca":false},{"name":"Philip T. T. Ly","is_ca":true},{"name":"Sandra I. Mota","is_ca":false},{"name":"Carla Lopes","is_ca":false},{"name":"Carina Maranga","is_ca":false},{"name":"Patrícia Coelho","is_ca":false},{"name":"Noga Gershoni‐Emek","is_ca":false},{"name":"Maria Ankarcrona","is_ca":false},{"name":"Michal Geva","is_ca":false},{"name":"Michael R. Hayden","is_ca":true},{"name":"A. Cristina Rego","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01848191230699497,"gpt":0.263666797278065,"spread":0.24518488497107,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001949943,0.0002707131,0.0004234952,0.0002366477,0.0001571395,0.0002713261,0.0003023348,0.0003868511,0.001386803],"category_scores_gemma":[0.0001545633,0.0001470821,0.0002487385,0.0001090641,0.0002488274,0.0001968713,0.0001673008,0.0007326681,0.000355068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294995,"about_ca_system_score_gemma":0.000212662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008552669,"about_ca_topic_score_gemma":0.001788678,"domain_scores_codex":[0.9998817,0.00002613531,0.00001518714,0.0000186187,0.00002279019,0.00003559949],"domain_scores_gemma":[0.9998624,0.00001860652,0.00003330505,0.0000225793,0.00001800161,0.00004513812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008445717,0.00006529653,0.0001758449,0.00003242471,0.00001197976,0.000109728,0.00002720807,0.00005596246,0.9967573,0.0001516634,0.00005798296,0.001709992],"study_design_scores_gemma":[0.00009164352,0.001870815,0.004587986,0.00001246381,0.00003496049,0.0003321666,0.00007477032,0.000954146,0.9908369,0.000111677,0.001083549,0.000008958564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966322,0.0009476815,0.001145805,0.000118646,0.00003005324,0.00002060282,0.0002546795,0.00007467932,0.000775655],"genre_scores_gemma":[0.9964934,0.0005418826,0.0007577928,0.0000281626,0.000007773759,0.00001668224,0.0002153692,0.00001356282,0.001925506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386803,"threshold_uncertainty_score":0.004639268,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2027637695","doi":"10.1089/neu.2005.22.277","title":"Spreading Depression Expands Traumatic Injury in Neocortical Brain Slices","year":2005,"lang":"en","type":"article","venue":"Journal of Neurotrauma","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Heart and Stroke Foundation of Canada","keywords":"Cortical spreading depression; Neocortex; Traumatic brain injury; Neuroscience; Medicine; NMDA receptor; Anesthesia; Psychology; Receptor; Internal medicine; Psychiatry","authors":[{"name":"Alanna J. Church","is_ca":true},{"name":"R. David Andrew","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03462141858504068,"gpt":0.3484018520192069,"spread":0.3137804334341662,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142002,0.0007430465,0.0002472854,0.000260653,0.0002250921,0.000271538,0.0007533956,0.0003185321,0.001731002],"category_scores_gemma":[0.00007289652,0.000225964,0.000418657,0.0002925993,0.000263515,0.000249573,0.0003102616,0.0009830812,0.0007050827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002680603,"about_ca_system_score_gemma":0.000376364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002408484,"about_ca_topic_score_gemma":0.005015433,"domain_scores_codex":[0.9998192,0.00001463448,0.00002225002,0.00004741083,0.00005772591,0.00003882507],"domain_scores_gemma":[0.99991,0.00001439161,0.00002115387,0.00001712998,0.00001935207,0.00001811469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009858044,0.00004150734,0.00006941936,0.00007514626,0.00000703781,0.00009820145,0.00004896505,0.00006356376,0.9984034,0.0001295619,0.00004472717,0.0009200055],"study_design_scores_gemma":[0.00004502746,0.0005751551,0.003410711,0.00002747297,0.00003169867,0.0004327815,0.00005495508,0.001466747,0.9915311,0.0001294534,0.002287129,0.000007779613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458866,0.006029279,0.03175511,0.0002705118,0.0002574614,0.0004115041,0.002670743,0.000395276,0.01232361],"genre_scores_gemma":[0.9393532,0.006490938,0.04321803,0.0001615554,0.00005244642,0.0005685775,0.002250162,0.0001080086,0.007797133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002408484,"threshold_uncertainty_score":0.00579077,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2081937032","doi":"10.1017/s1461145708008547","title":"Further evidence for an antidepressant potential of the selective σ1 agonist SA 4503: electrophysiological, morphological and behavioural studies","year":2008,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Montreal Neurological Institute and Hospital; Hôpital Louis-H Lafontaine; McGill University; Université de Montréal","funders":"","keywords":"Serotonergic; Agonist; Hippocampal formation; Electrophysiology; Hippocampus; Antidepressant; Neuroscience; Antagonist; Inhibitory postsynaptic potential; Internal medicine; Endocrinology; Pharmacology; Medicine; Serotonin; Psychology; Receptor","authors":[{"name":"Guillaume Lucas","is_ca":true},{"name":"Vladimir V. Rymar","is_ca":true},{"name":"Abbas F. Sadikot","is_ca":true},{"name":"Guy Debonnel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0801446925942661,"gpt":0.3807668360838616,"spread":0.3006221434895955,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349605,0.0003043161,0.0003365026,0.0001605973,0.0001269303,0.0001516861,0.00019564,0.0003403579,0.001729319],"category_scores_gemma":[0.00009581463,0.00009029916,0.000317698,0.0001416736,0.0001444121,0.0001415773,0.0001068509,0.0004465194,0.0004243192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009654799,"about_ca_system_score_gemma":0.0001387209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004298085,"about_ca_topic_score_gemma":0.0008878025,"domain_scores_codex":[0.9999541,0.00001177976,0.000006718423,0.000006746654,0.00001007059,0.00001068923],"domain_scores_gemma":[0.9999151,0.00001772232,0.00002248726,0.00001250755,0.00001765537,0.00001444757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001709833,0.00004658255,0.0002855259,0.00009556997,0.00001209201,0.00008870368,0.00001297511,0.0000275126,0.9966161,0.00003322846,0.00001606309,0.002594627],"study_design_scores_gemma":[0.0001269055,0.01233879,0.05917563,0.00004828722,0.000200056,0.002198435,0.0001351985,0.0009105913,0.9209142,0.0001789375,0.003755022,0.00001801768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989697,0.00467563,0.003499418,0.0001482688,0.00002617548,0.00006716374,0.0004092785,0.00004361596,0.001433373],"genre_scores_gemma":[0.9913772,0.00417025,0.002726451,0.0001769807,0.00004282688,0.0000531513,0.0005074887,0.000006100219,0.0009395909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729319,"threshold_uncertainty_score":0.005785108,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3111810969","doi":"10.3389/fphar.2020.577678","title":"The Large Action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19","year":2020,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Coronavirus; Chlorpromazine; Context (archaeology); Medicine; Pandemic; Coronavirus disease 2019 (COVID-19); Antipsychotic; Disease; Virology; Psychiatry; Pharmacology; Schizophrenia (object-oriented programming); Infectious disease (medical specialty); Biology; Internal medicine","authors":[{"name":"Émmanuel Stip","is_ca":true},{"name":"Tahir A. Rizvi","is_ca":false},{"name":"Farah Mustafa","is_ca":false},{"name":"Syed Fahad Javaid","is_ca":false},{"name":"Salahdein Aburuz","is_ca":false},{"name":"Nahida Nayaz Ahmed","is_ca":false},{"name":"Karim Abdel Aziz","is_ca":false},{"name":"Danilo Arnone","is_ca":false},{"name":"Aravinthan Subbarayan","is_ca":false},{"name":"Fadwa Al Mugaddam","is_ca":true},{"name":"Gulfaraz Khan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03175632532293857,"gpt":0.3385057594976228,"spread":0.3067494341746842,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002687054,0.000318755,0.0006999003,0.0006204841,0.0005254459,0.002169283,0.0007663431,0.002432494,0.003654202],"category_scores_gemma":[0.003822647,0.0001313911,0.0006093468,0.0005983268,0.00141272,0.002715564,0.001221269,0.003699353,0.0008786417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00130749,"about_ca_system_score_gemma":0.004206182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156832,"about_ca_topic_score_gemma":0.003163461,"domain_scores_codex":[0.9989589,0.0005486858,0.00009720061,0.0001153813,0.0001813683,0.00009845261],"domain_scores_gemma":[0.9972844,0.001509943,0.0002174746,0.00007749743,0.0006290204,0.0002816514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004604534,0.0001447842,0.001269807,0.01177171,0.0001181627,0.001750237,0.001848391,0.0003858609,0.003118041,0.03667794,0.06341552,0.8790391],"study_design_scores_gemma":[0.0000654529,0.0004687512,0.001789273,0.007105045,0.0001339002,0.003304996,0.002147425,0.0002613022,0.001145183,0.01931817,0.9642081,0.00005248911],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.002444788,0.9180574,0.001117507,0.06700271,0.002757463,0.00001918317,0.000046146,0.00002857319,0.008526276],"genre_scores_gemma":[0.03361955,0.9302738,0.002769393,0.02286061,0.006007487,0.00007703256,0.00006665596,0.00002325715,0.004302217],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003654202,"threshold_uncertainty_score":0.01421064,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2055480661","doi":"10.1038/sj.tpj.6500373","title":"Haloperidol induces apoptosis via the σ2 receptor system and Bcl-XS","year":2006,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Health Canada; Saskatchewan Health Research Foundation; Saskatchewan Cancer Agency","keywords":"Haloperidol; Apoptosis; Receptor; Chemistry; Pharmacology; Neuroscience; Medicine; Biology; Biochemistry; Dopamine","authors":[{"name":"Zhao Wei","is_ca":true},{"name":"Darrell D. Mousseau","is_ca":true},{"name":"Yilong Dai","is_ca":true},{"name":"Xia Cao","is_ca":true},{"name":"Li Xm","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01069070362637483,"gpt":0.2437987354319689,"spread":0.2331080318055941,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281402,0.0003208126,0.0001702715,0.0003741847,0.0002185529,0.0003248905,0.0001796965,0.0002696362,0.001973079],"category_scores_gemma":[0.0001866095,0.0001297762,0.0002246737,0.0001567496,0.000226296,0.0002222054,0.0002011719,0.0004195013,0.0003965185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116728,"about_ca_system_score_gemma":0.0002326495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005480006,"about_ca_topic_score_gemma":0.000739606,"domain_scores_codex":[0.9998608,0.0000317039,0.000007201351,0.00001039153,0.00003380786,0.00005616803],"domain_scores_gemma":[0.9998505,0.00003635089,0.00004076387,0.00002842955,0.00001612251,0.00002778078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001092578,0.00008094348,0.001057062,0.00007854631,0.00003539047,0.0004005787,0.00004918529,0.0001039228,0.9883621,0.0005531464,0.0002969686,0.00788951],"study_design_scores_gemma":[0.0001283898,0.001191455,0.02379584,0.00001766565,0.00004896538,0.001001637,0.0001267856,0.0007518755,0.9693899,0.0005386526,0.002993169,0.00001560573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914418,0.002931834,0.001264891,0.0003396547,0.00003108981,0.00001876672,0.0002207902,0.0001646757,0.003586583],"genre_scores_gemma":[0.9968377,0.0008344,0.0002686922,0.0000735611,0.00001518807,0.00001364096,0.0001382297,0.000005661527,0.001812909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001973079,"threshold_uncertainty_score":0.006600678,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1700971463","doi":"10.1046/j.1365-2125.2003.01825.x","title":"Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady‐state in healthy subjects","year":2003,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Pharmacokinetics; Pharmacology; Anticonvulsant; Phenobarbital; Carbamazepine; Metabolite; Chemistry; Active metabolite; Oral administration; Medicine; Internal medicine; Epilepsy","authors":[{"name":"Géraldine M. Ferron","is_ca":true},{"name":"Alain Patat","is_ca":false},{"name":"Virginia Parks","is_ca":false},{"name":"Paul Rolan","is_ca":false},{"name":"Steven Troy","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06827370664692188,"gpt":0.4242591758030635,"spread":0.3559854691561417,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003849668,0.0002774614,0.0004439392,0.0001583314,0.0003121953,0.0003414062,0.00009941981,0.0003163766,0.001370012],"category_scores_gemma":[0.0007917496,0.0001697502,0.0001633225,0.0001055993,0.0002087051,0.000168079,0.0001020696,0.0002572091,0.0003724548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942787,"about_ca_system_score_gemma":0.0001821219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002406938,"about_ca_topic_score_gemma":0.002116826,"domain_scores_codex":[0.9997374,0.00006743903,0.00001634868,0.00008590751,0.00005859724,0.00003427158],"domain_scores_gemma":[0.9997117,0.00008376834,0.00007801726,0.00002827005,0.00003173114,0.00006646336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01440611,0.001197652,0.8750243,0.000134042,0.0005395666,0.002271654,0.0006380609,0.0003907091,0.06748254,0.0001381003,0.0006574157,0.03711988],"study_design_scores_gemma":[0.0001505387,0.006529497,0.987163,0.00000469837,0.0001420497,0.002224691,0.00007466412,0.0005299028,0.002286154,0.00004954591,0.0008362125,0.000009122595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988354,0.0004184438,0.0001858975,0.0000142617,0.000004532532,0.00001443803,0.00008346065,0.00001257286,0.0004310877],"genre_scores_gemma":[0.9992381,0.0001125611,0.0001130632,0.00004520753,0.000009327908,0.000008336053,0.0001492323,0.000002874287,0.0003212735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002406938,"threshold_uncertainty_score":0.004785895,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2166527415","doi":"10.1677/joe.0.1820011","title":"Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids","year":2004,"lang":"en","type":"article","venue":"Journal of Endocrinology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Neuroactive steroid; Allopregnanolone; Endocrinology; Internal medicine; Dehydroepiandrosterone; Dorsal raphe nucleus; Serotonergic; Pregnanolone; Pregnenolone; Pregnenolone sulfate; Chemistry; Androgen; Serotonin; GABAA receptor; Receptor; Biology; Steroid; Medicine; Hormone","authors":[{"name":"Malika Robichaud","is_ca":true},{"name":"Guy Debonnel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0138559094393322,"gpt":0.2689293830822732,"spread":0.255073473642941,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006044666,0.0002134186,0.0002025838,0.0001378059,0.00009996834,0.000195349,0.0001205596,0.0001972885,0.001870278],"category_scores_gemma":[0.0001187229,0.0001197728,0.0001539364,0.00008266388,0.0002491736,0.0001303212,0.00008186193,0.0003644796,0.0003846441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612182,"about_ca_system_score_gemma":0.0001805986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007597821,"about_ca_topic_score_gemma":0.001466233,"domain_scores_codex":[0.9999336,0.00001054763,0.000003324679,0.00001439815,0.00001298098,0.00002509512],"domain_scores_gemma":[0.9999028,0.00001589795,0.00002963901,0.00001197155,0.000009370762,0.0000302318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100821,0.00006350395,0.001069232,0.0000506289,0.00001313704,0.0001578227,0.0000332066,0.00004794445,0.9912395,0.00006667151,0.00004429838,0.006113162],"study_design_scores_gemma":[0.00009768962,0.007018181,0.06480044,0.0000197917,0.00006382668,0.0008734792,0.0001957658,0.0005356665,0.9243672,0.0001062811,0.001908336,0.00001338656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961361,0.00174378,0.0004596064,0.00007026045,0.00002384851,0.00001119011,0.0002209935,0.00002300547,0.001311217],"genre_scores_gemma":[0.9934047,0.002104272,0.0006827761,0.00004024319,0.00002445542,0.00002508711,0.0002608817,0.000006653923,0.003450815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870278,"threshold_uncertainty_score":0.0062567,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3154903409","doi":"10.3390/ijms22084082","title":"Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"National Institute on Aging; National Institute of Neurological Disorders and Stroke; Russian Science Support Foundation","keywords":"Sigma-1 receptor; Receptor; Endoplasmic reticulum; Biology; Effector; Cell biology; Biochemistry; Agonist","authors":[{"name":"Vladimir Zhemkov","is_ca":false},{"name":"Michal Geva","is_ca":false},{"name":"Michael R. Hayden","is_ca":true},{"name":"Ilya Bezprozvanny","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01131557073468404,"gpt":0.286900247791249,"spread":0.275584677056565,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003328238,0.000495934,0.0003999404,0.0004205077,0.0002392088,0.0004318274,0.0002078639,0.0005365709,0.0004952484],"category_scores_gemma":[0.0001013741,0.0001258714,0.0004450383,0.0002667842,0.0005892981,0.0002657411,0.000354072,0.000423202,0.0002181484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004315272,"about_ca_system_score_gemma":0.0002494374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006391859,"about_ca_topic_score_gemma":0.0005923792,"domain_scores_codex":[0.9998596,0.0000367853,0.00001556097,0.00002663261,0.00003214817,0.00002921106],"domain_scores_gemma":[0.9999149,0.00000889521,0.00003723748,0.000005530224,0.00001362846,0.00001992249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006835687,0.00005500331,0.005294927,0.000637229,0.00006246373,0.000931853,0.000130429,0.0002211707,0.9701256,0.001878641,0.0003166487,0.01966243],"study_design_scores_gemma":[0.0001507271,0.001707401,0.07730563,0.0002191139,0.0003075433,0.005699102,0.0005849163,0.002736667,0.8845035,0.003997692,0.02272504,0.0000625125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8450267,0.1443142,0.006812165,0.001575296,0.000095138,0.00004611058,0.0002382731,0.0001171245,0.001774907],"genre_scores_gemma":[0.9434768,0.05198449,0.002135065,0.0002556094,0.00007783137,0.00003064592,0.0002131775,0.000006001007,0.001820356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006391859,"threshold_uncertainty_score":0.003130913,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2049591446","doi":"10.1002/syn.20085","title":"Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus","year":2004,"lang":"en","type":"article","venue":"Synapse","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"NMDA receptor; Sigma-1 receptor; Sigma receptor; Glutamatergic; Agonist; Neuroscience; Long-term potentiation; AMPA receptor; Chemistry; Hippocampal formation; Receptor; Pharmacology; Neurotransmission; Glutamate receptor; Biology; Biochemistry","authors":[{"name":"Jordanna E. Bermack","is_ca":true},{"name":"Guy Debonnel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01014021866324499,"gpt":0.2622228733659773,"spread":0.2520826547027323,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007080227,0.0002698669,0.0003405107,0.0002188555,0.00008079733,0.0002499533,0.0001954312,0.0001903209,0.0009879802],"category_scores_gemma":[0.0001322198,0.0001503607,0.0002126543,0.0001092093,0.0002167911,0.0002343207,0.0002126839,0.0003050571,0.0001998934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001930007,"about_ca_system_score_gemma":0.000163883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006374621,"about_ca_topic_score_gemma":0.001374424,"domain_scores_codex":[0.9999125,0.00001546663,0.00001178505,0.00001363535,0.00001961919,0.0000269115],"domain_scores_gemma":[0.9999313,0.000009059503,0.00001773416,0.000005702619,0.00001332411,0.00002283496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002251647,0.000007344796,0.0004307578,0.00003016735,0.000007545802,0.00008583927,0.00001996719,0.00001298673,0.9978084,0.00004313957,0.000006720778,0.001321961],"study_design_scores_gemma":[0.00005517938,0.001476967,0.07699151,0.00003310584,0.0001004645,0.001024663,0.0004164708,0.0006322231,0.9181129,0.0002121434,0.0009264796,0.00001778662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971506,0.00120162,0.0005387118,0.0000343088,0.000006402949,0.000008069054,0.0001076984,0.00001302891,0.0009394881],"genre_scores_gemma":[0.996506,0.001613113,0.0007051296,0.00003745417,0.000006839618,0.00001686251,0.0001334702,0.000004663569,0.0009765027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009879802,"threshold_uncertainty_score":0.003305137,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2806871172","doi":"10.1186/s13024-018-0259-3","title":"Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse","year":2018,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Child and Family Research Institute","funders":"Teva Pharmaceutical Industries","keywords":"Neuroprotection; Transcriptome; Neurology; Neuroscience; Gene expression; Neurochemistry; Gene; Biology; Bioinformatics; Cell biology; Medicine; Genetics","authors":[{"name":"Rebecca Kusko","is_ca":false},{"name":"Jennifer Dreymann","is_ca":false},{"name":"Jermaine Ross","is_ca":false},{"name":"Yoonjeong Cha","is_ca":false},{"name":"Renan Escalante-Chong","is_ca":false},{"name":"Marta Garcia‐Miralles","is_ca":false},{"name":"Liang Tan","is_ca":false},{"name":"Michael E. Burczynski","is_ca":false},{"name":"Ben Zeskind","is_ca":false},{"name":"Daphna Laifenfeld","is_ca":false},{"name":"Mahmoud A. Pouladi","is_ca":false},{"name":"Michal Geva","is_ca":false},{"name":"Iris Grossman","is_ca":false},{"name":"Michael R. Hayden","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0163935122708532,"gpt":0.2469463959926836,"spread":0.2305528837218304,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001818084,0.0004730072,0.0004087116,0.000752726,0.0002266048,0.0003745549,0.00030234,0.0004325855,0.001514224],"category_scores_gemma":[0.00009279008,0.0002446017,0.0004790782,0.0003580671,0.0003447383,0.0001557639,0.0001890201,0.0008913072,0.0007148485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002714278,"about_ca_system_score_gemma":0.0001856159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008338125,"about_ca_topic_score_gemma":0.001796653,"domain_scores_codex":[0.9998083,0.000007986166,0.00001391128,0.00007029887,0.00005773128,0.00004185753],"domain_scores_gemma":[0.9996976,0.00003902711,0.0001070327,0.00003811771,0.00004262516,0.00007564355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008937743,0.00001106969,0.0001855637,0.00001483523,0.000006295205,0.00004285257,0.000009714081,0.00002316947,0.9991736,0.00003243414,0.00002879178,0.0003823271],"study_design_scores_gemma":[0.00005397932,0.0005200796,0.02866368,0.00001864085,0.00006827342,0.0005720166,0.00007471906,0.0009333469,0.9655039,0.00009333615,0.003484742,0.00001332293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972061,0.00200213,0.009457956,0.0001813174,0.00006517008,0.00009496797,0.01378527,0.0003403277,0.002011956],"genre_scores_gemma":[0.9503856,0.002279127,0.01382062,0.0002507957,0.0000416148,0.0003461171,0.019366,0.0003821015,0.01312803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001514224,"threshold_uncertainty_score":0.00506562,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3011896036","doi":"10.1002/jmv.25752","title":"Potentially repurposing adamantanes for COVID‐19","year":2020,"lang":"en","type":"letter","venue":"Journal of Medical Virology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Virology; Repurposing; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus Infections; Betacoronavirus; Medicine; Drug repositioning; Biology; Outbreak; Infectious disease (medical specialty); Pharmacology; Disease; Drug","authors":[{"name":"Nevio Cimolai","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02858052666149567,"gpt":0.328995123564872,"spread":0.3004145969033764,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011209,0.000565873,0.0007143993,0.0002039352,0.0006645385,0.001117603,0.0007938077,0.008690914,0.003972692],"category_scores_gemma":[0.002851535,0.0002360096,0.0007461751,0.000146381,0.001030619,0.001001235,0.0004932837,0.006190449,0.001991383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001188509,"about_ca_system_score_gemma":0.0005245866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003335098,"about_ca_topic_score_gemma":0.0006446037,"domain_scores_codex":[0.9994625,0.0001401499,0.00007805392,0.00005748534,0.0001459942,0.0001158159],"domain_scores_gemma":[0.9994481,0.0002757728,0.00006991444,0.00004236855,0.00004980822,0.0001140036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003458306,0.00066211,0.003367617,0.0009080992,0.0001566134,0.1569534,0.0004771443,0.0009420498,0.05575743,0.04690172,0.5834975,0.1469181],"study_design_scores_gemma":[0.001033238,0.001028283,0.001589607,0.0001566084,0.00007051498,0.04176887,0.0001909487,0.001352982,0.02815109,0.02003177,0.9045743,0.00005179084],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04803045,0.05450896,0.00312776,0.8205453,0.03442519,0.0001769093,0.0003300809,0.0003072249,0.03854813],"genre_scores_gemma":[0.4851076,0.03642003,0.00563105,0.3433231,0.06774458,0.0003373168,0.0004214478,0.0001495722,0.0608653],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.008690914,"threshold_uncertainty_score":0.01328993,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3215398075","doi":"10.1007/s40265-021-01636-5","title":"Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence","year":2021,"lang":"en","type":"review","venue":"Drugs","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"","funders":"W. M. Keck Foundation","keywords":"Medicine; Fluvoxamine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pharmacotherapy; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Intensive care medicine; Betacoronavirus; Pandemic; Virology; Psychiatry; Internal medicine; Disease; Outbreak; Infectious disease (medical specialty); Fluoxetine","authors":[{"name":"Shelley N. Facente","is_ca":false},{"name":"Angela M. Reiersen","is_ca":false},{"name":"Eric J. Lenze","is_ca":false},{"name":"David R. Boulware","is_ca":false},{"name":"Jeffrey D. Klausner","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.16758524708012,"gpt":0.4518696597222465,"spread":0.2842844126421266,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001878366,0.0006719448,0.002393217,0.002593947,0.0003290341,0.001433198,0.001416787,0.001769618,0.003514712],"category_scores_gemma":[0.003578799,0.0004015444,0.00181334,0.002295273,0.0005412826,0.001716362,0.0005505033,0.001966623,0.0006862186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006844107,"about_ca_system_score_gemma":0.001703288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001543166,"about_ca_topic_score_gemma":0.002973371,"domain_scores_codex":[0.9994279,0.0001198063,0.0001870155,0.00008450624,0.0001504281,0.00003025793],"domain_scores_gemma":[0.9973196,0.001784971,0.0003699993,0.00003359224,0.000412869,0.00007897493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004129082,0.0001511926,0.0004128178,0.129199,0.0006920566,0.0002503024,0.0001240663,0.0002141846,0.0007606515,0.001716594,0.0252406,0.8408256],"study_design_scores_gemma":[0.000335408,0.000803827,0.003474224,0.1678521,0.004168993,0.002432568,0.0003074589,0.0003124473,0.0006650329,0.002575698,0.8170008,0.00007152122],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007064865,0.9993796,0.00002701073,0.0002763726,0.00009274545,0.000005081229,0.00001175229,0.000002327643,0.0001344431],"genre_scores_gemma":[0.0005868911,0.9987308,0.0001140963,0.0003540089,0.0001220592,0.000009965807,0.00001632486,0.00000109484,0.0000645996],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003514712,"threshold_uncertainty_score":0.01175785,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4406235559","doi":"10.1016/j.tjpad.2024.100016","title":"Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial","year":2025,"lang":"en","type":"article","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Toronto Western Hospital; Dynacast (Canada); Greenfield Research (Canada); University of British Columbia Hospital; Bruyère; Western University; Baycrest Hospital; South Health Campus; Parkwood Institute; SKiN Health; Island Health","funders":"","keywords":"Disease; Medicine; Internal medicine","authors":[{"name":"Stephen Macfarlane","is_ca":false},{"name":"Timo Grimmer","is_ca":false},{"name":"Ken Teo","is_ca":false},{"name":"Terence J. O’Brien","is_ca":false},{"name":"Mark Woodward","is_ca":false},{"name":"Jennifer Grunfeld","is_ca":false},{"name":"Alastair Mander","is_ca":false},{"name":"Amy Brodtmann","is_ca":false},{"name":"Bruce J. Brew","is_ca":false},{"name":"Philip Morris","is_ca":false},{"name":"C Short","is_ca":false},{"name":"Susan Kurrle","is_ca":false},{"name":"Rosalyn Lai","is_ca":false},{"name":"Sneha Bharadwaj","is_ca":false},{"name":"Peter Drysdale","is_ca":false},{"name":"Jonathan Sturm","is_ca":false},{"name":"Simon J.G. Lewis","is_ca":false},{"name":"Dávid Barton","is_ca":false},{"name":"Chris Kalafatis","is_ca":false},{"name":"Richard Perry","is_ca":false},{"name":"Nicholas Mannering","is_ca":false},{"name":"Josephine Emer MacSweeney","is_ca":false},{"name":"Stephen Pearson","is_ca":false},{"name":"Craig Evans","is_ca":false},{"name":"Vivek Krishna","is_ca":false},{"name":"Alex Thompson","is_ca":false},{"name":"Malathy Munisamy","is_ca":false},{"name":"Neel S. Bhatt","is_ca":false},{"name":"Aliya Asher","is_ca":false},{"name":"Jennifer Lynch","is_ca":false},{"name":"Sterre Malou Rutgers","is_ca":false},{"name":"P. L. J. Dautzenberg","is_ca":false},{"name":"Niels D. Prins","is_ca":false},{"name":"Patrick Oschmann","is_ca":false},{"name":"Paweł Tacik","is_ca":false},{"name":"Oliver Peters","is_ca":false},{"name":"Jens Wiltfang","is_ca":false},{"name":"Alexandre Henri‐Bhargava","is_ca":true},{"name":"Eric E. Smith","is_ca":true},{"name":"Stephen Pasternak","is_ca":true},{"name":"Andrew Frank","is_ca":true},{"name":"Howard Chertkow","is_ca":true},{"name":"Ging‐Yuek Robin Hsiung","is_ca":true},{"name":"Sharon Cohen","is_ca":false},{"name":"Luca M. Villa","is_ca":false},{"name":"Elizabeth Gordón","is_ca":false},{"name":"Thomas Jubault","is_ca":true},{"name":"Nicolas Guizard","is_ca":true},{"name":"A. Tucker","is_ca":false},{"name":"Walter E. Kaufmann","is_ca":false},{"name":"Kun Jin","is_ca":false},{"name":"William R Chezem","is_ca":false},{"name":"Christopher U. Missling","is_ca":false},{"name":"Marwan N. Sabbagh","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03982232699634509,"gpt":0.3600186675016275,"spread":0.3201963405052824,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001399836,0.0008136356,0.001027468,0.0002197216,0.0002386723,0.0007028978,0.0004795988,0.0007705736,0.004143162],"category_scores_gemma":[0.000732968,0.000204269,0.001258626,0.0002481004,0.0003512402,0.0003904834,0.0001612751,0.001442231,0.0006264019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005785247,"about_ca_system_score_gemma":0.0009285826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00118412,"about_ca_topic_score_gemma":0.00426573,"domain_scores_codex":[0.9997639,0.0001230945,0.00001521563,0.00002885581,0.00003063459,0.00003831695],"domain_scores_gemma":[0.9995937,0.00008331853,0.0001048182,0.0000277755,0.00004851785,0.0001418533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7953124,0.01028848,0.003213655,0.002433643,0.003195514,0.0001619853,0.0001219627,0.0008927608,0.0158439,0.0003382263,0.009112858,0.1590846],"study_design_scores_gemma":[0.8757507,0.09623586,0.01517322,0.0002691329,0.002372295,0.0002212996,0.00006107768,0.0006533656,0.001725323,0.0003344236,0.00716959,0.00003373152],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454158,0.03889822,0.0006405088,0.001447235,0.0004046733,0.002181926,0.003681247,0.000152609,0.007177672],"genre_scores_gemma":[0.9671046,0.01678503,0.001848207,0.002148479,0.0003978259,0.002137005,0.004896552,0.000034376,0.00464788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004143162,"threshold_uncertainty_score":0.01386023,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1964995550","doi":"10.1139/cjc-2014-0552","title":"Recent advances in process development for opiate-derived pharmaceutical agents","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"Brock University","funders":"","keywords":"Nalbuphine; Thebaine; Chemistry; Opiate; Buprenorphine; (+)-Naloxone; Pharmacology; Biochemical engineering; Morphine; Opioid; Codeine; Medicine","authors":[{"name":"Tomáš Hudlický","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04082475686452589,"gpt":0.3346523138617837,"spread":0.2938275569972578,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001496088,0.001047747,0.0006381086,0.001261208,0.0004780714,0.001133427,0.0007884969,0.000735617,0.003019126],"category_scores_gemma":[0.0009616123,0.0005089568,0.0008319589,0.00127029,0.0008415398,0.002063569,0.001259175,0.001717921,0.001975341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008357418,"about_ca_system_score_gemma":0.001199396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007173377,"about_ca_topic_score_gemma":0.0008961231,"domain_scores_codex":[0.999206,0.0001044392,0.00007636514,0.0001973221,0.000318318,0.00009762454],"domain_scores_gemma":[0.9994131,0.0002453816,0.0001082785,0.00006028136,0.000130086,0.00004283828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002564128,0.0003373794,0.0007271487,0.01496532,0.0001452972,0.0007158213,0.000614694,0.003204016,0.3138967,0.02512543,0.003101979,0.6369098],"study_design_scores_gemma":[0.0000446995,0.00120727,0.001254538,0.0005917017,0.0002158092,0.002570336,0.0002532161,0.002931235,0.4179316,0.007504517,0.56539,0.000105169],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03967016,0.7818971,0.1433373,0.00168937,0.0007141673,0.0002389205,0.0002464487,0.0004673889,0.03173914],"genre_scores_gemma":[0.1269234,0.7943559,0.06867768,0.0006509739,0.000807784,0.0001790218,0.0004354132,0.0001545597,0.007815256],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003019126,"threshold_uncertainty_score":0.01009995,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4317425523","doi":"10.3390/ijms24031971","title":"Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection","year":2023,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Concordia University; Université du Québec à Montréal","funders":"National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois","keywords":"Neuroprotection; Endoplasmic reticulum; Unfolded protein response; Autophagy; Sigma-1 receptor; Cell biology; Subcellular localization; Mitochondrion; Flux (metallurgy); Biology; Chemistry; Neuroscience; Biochemistry; Cytoplasm; Apoptosis; Receptor; Agonist","authors":[{"name":"Véronik Lachance","is_ca":true},{"name":"Sara-Maude Bélanger","is_ca":true},{"name":"Célia Hay","is_ca":true},{"name":"Victoria Le Corvec","is_ca":true},{"name":"Vina Banouvong","is_ca":true},{"name":"Mathieu Lapalme","is_ca":true},{"name":"Khadija Tarmoun","is_ca":true},{"name":"Guillaume Beaucaire","is_ca":true},{"name":"Marc Lussier","is_ca":true},{"name":"Saı̈d Kourrich","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1048286771414206,"gpt":0.3749610683930759,"spread":0.2701323912516552,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003862585,0.0008396548,0.0009767974,0.002281915,0.0002862478,0.000688999,0.000660709,0.0008054955,0.003486372],"category_scores_gemma":[0.0003800008,0.0003036188,0.0004664886,0.001966564,0.000284541,0.0009814762,0.0004815781,0.00148327,0.001824533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000564959,"about_ca_system_score_gemma":0.001036157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142151,"about_ca_topic_score_gemma":0.001742093,"domain_scores_codex":[0.9999013,0.00001314339,0.00002012974,0.00002210537,0.00003172136,0.00001161191],"domain_scores_gemma":[0.9998405,0.00005980143,0.00002294717,0.000005001285,0.00005110918,0.00002050693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001467803,0.00008896885,0.0002147801,0.02956162,0.0001143345,0.0003286164,0.000079064,0.0004590696,0.006485106,0.005238713,0.03138074,0.9259022],"study_design_scores_gemma":[0.00001538943,0.000157218,0.0008474365,0.002813372,0.0001354113,0.001103826,0.00004741852,0.00008815551,0.001255049,0.001668054,0.9918504,0.00001819027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001769224,0.9979514,0.0001816949,0.0002240447,0.0001885971,0.000005699681,0.00003913848,0.00001023577,0.001222228],"genre_scores_gemma":[0.0006833554,0.9981955,0.0002262655,0.0001468104,0.0001151787,0.000007253141,0.00005318658,0.000001383605,0.0005712071],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003486372,"threshold_uncertainty_score":0.01166308,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2004815722","doi":"10.1371/journal.pone.0011496","title":"Endoplasmic Reticulum Protein Targeting of Phospholamban: A Common Role for an N-Terminal Di-Arginine Motif in ER Retention?","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Toronto General Hospital; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Endoplasmic reticulum; Phospholamban; Arginine; ER retention; Golgi apparatus; Cell biology; Biology; Chemistry; Amino acid; Biochemistry; Gene; Mutant","authors":[{"name":"Parveen Sharma","is_ca":true},{"name":"Vladimir Ignatchenko","is_ca":true},{"name":"Kevin P. Grace","is_ca":true},{"name":"Claudia Ursprung","is_ca":true},{"name":"Thomas Kislinger","is_ca":true},{"name":"Anthony O. Gramolini","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01955270860894351,"gpt":0.2563480150961478,"spread":0.2367953064872043,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993718,0.0004228183,0.0004326309,0.0001800426,0.0001636949,0.0004140202,0.0004102634,0.0005542397,0.001524211],"category_scores_gemma":[0.0001613655,0.0001298457,0.0003599431,0.0001463888,0.0002992644,0.0005647991,0.0003612686,0.0003857832,0.001093427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002864993,"about_ca_system_score_gemma":0.0001077168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001042161,"about_ca_topic_score_gemma":0.000104188,"domain_scores_codex":[0.9998581,0.00001124965,0.00001708468,0.00006787899,0.00002597665,0.00001971919],"domain_scores_gemma":[0.9998111,0.00001232273,0.0000894662,0.0000208231,0.00002578332,0.00004052064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003633042,0.00003048171,0.00110316,0.0001358348,0.00001388431,0.0006644938,0.00003827243,0.00008142569,0.9943118,0.0003821934,0.00009109431,0.00278411],"study_design_scores_gemma":[0.0001036242,0.0004174076,0.04424752,0.00006534305,0.00008728804,0.01060345,0.0002553309,0.004423927,0.9252928,0.001123084,0.01334292,0.00003745143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824283,0.006115471,0.009051039,0.0004626598,0.00005277982,0.00003492454,0.0002933679,0.0001017271,0.001459741],"genre_scores_gemma":[0.9857093,0.002552491,0.007331203,0.0003039086,0.00003814648,0.00003538702,0.001020679,0.00004390335,0.00296501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001524211,"threshold_uncertainty_score":0.005098999,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1673459884","doi":"","title":"Antidepressants upregulate messenger RNA levels of the neuroprotective enzyme superoxide dismutase (SOD1).","year":2000,"lang":"en","type":"article","venue":"PubMed","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Neuroprotection; Superoxide dismutase; Bupropion; Pharmacology; Doxepin; Amitriptyline; Viability assay; SOD1; Antidepressant; Venlafaxine; Chemistry; Messenger RNA; Endocrinology; Internal medicine; Medicine; Oxidative stress; Cell; Biochemistry; Gene; Hippocampus","authors":[{"name":"Xin-Min Li","is_ca":true},{"name":"Jennifer Chlan‐Fourney","is_ca":false},{"name":"A. V. Juorio","is_ca":false},{"name":"Vern L. Bennett","is_ca":false},{"name":"Satish Shrikhande","is_ca":false},{"name":"Rudy Bowen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01556571156636877,"gpt":0.2251741584113952,"spread":0.2096084468450265,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007300498,0.000271766,0.0001778736,0.0001615665,0.0001497234,0.0002103724,0.00009660068,0.000205001,0.001885284],"category_scores_gemma":[0.0001595634,0.0001358494,0.0001881041,0.0001033683,0.0001306281,0.0001160192,0.00006832363,0.00021604,0.000393705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002278744,"about_ca_system_score_gemma":0.0001229945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004897059,"about_ca_topic_score_gemma":0.001194372,"domain_scores_codex":[0.999935,0.000008513618,0.000007284556,0.00001842298,0.00001668525,0.00001401233],"domain_scores_gemma":[0.9998604,0.00003705616,0.00005849495,0.000009872445,0.00001954465,0.00001457239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105298,0.00001407145,0.0004797292,0.00007447817,0.000008086491,0.00005915253,0.00001372139,0.00001151343,0.9970951,0.00002463329,0.00003582555,0.002078369],"study_design_scores_gemma":[0.00003245389,0.0008548782,0.04874742,0.00003151779,0.00007859158,0.0004926104,0.00008930045,0.0001552667,0.9468166,0.00005476153,0.002641909,0.000004822401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903007,0.005659708,0.0009831099,0.0001542085,0.00005563554,0.00002930714,0.0007039088,0.00004337936,0.002070147],"genre_scores_gemma":[0.9861674,0.006265938,0.00246939,0.0001365337,0.0000403227,0.00005087413,0.001043343,0.00001153764,0.003814751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885284,"threshold_uncertainty_score":0.006306946,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4366140579","doi":"10.7326/m22-3305","title":"Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19","year":2023,"lang":"en","type":"article","venue":"Annals of Internal Medicine","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Achieve Life Sciences (Canada); McGill University Health Centre; Stantec (Canada); Impact; McMaster University","funders":"Universidade Federal de Ouro Preto; University of Toronto; University of Oxford; McMaster University; King's College London; McGill University; McGill University Health Centre; Rainwater Charitable Foundation; Pontifícia Universidade Católica de Minas Gerais; National Institute for Health and Care Research; University of Minnesota; Georgetown University","keywords":"Medicine; Budesonide; Fluvoxamine; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Asthma; Pediatrics; Internal medicine; Psychiatry; Virology; Outbreak; Disease; Fluoxetine","authors":[{"name":"Gilmar Reis","is_ca":true},{"name":"Eduardo Augusto dos Santos Moreira Silva","is_ca":false},{"name":"Daniela Carla Medeiros Silva","is_ca":false},{"name":"Lehana Thabane","is_ca":true},{"name":"Vitoria Helena de Souza Campos","is_ca":true},{"name":"Thiago Santiago Ferreira","is_ca":false},{"name":"Castilho Vitor Quirino dos Santos","is_ca":false},{"name":"Ana Maria Ribeiro Nogueira","is_ca":false},{"name":"Leonardo Cançado Monteiro Savassi","is_ca":false},{"name":"Adhemar Dias de Figueiredo Neto","is_ca":false},{"name":"Carina Bitarães","is_ca":false},{"name":"Aline Cruz Milagres","is_ca":false},{"name":"Eduardo Diniz Callegari","is_ca":false},{"name":"Maria Izabel Campos Simplicio","is_ca":false},{"name":"Luciene Barra Ribeiro","is_ca":false},{"name":"Rosemary Oliveira","is_ca":false},{"name":"Ofir Harari","is_ca":false},{"name":"Lindsay A. Wilson","is_ca":false},{"name":"Jamie I. Forrest","is_ca":true},{"name":"Hinda Ruton","is_ca":false},{"name":"Sheila Sprague","is_ca":true},{"name":"Paula McKay","is_ca":true},{"name":"Christina M. Guo","is_ca":false},{"name":"Gordon Guyatt","is_ca":true},{"name":"Craig R. Rayner","is_ca":false},{"name":"David R. Boulware","is_ca":false},{"name":"Nicole Ezer","is_ca":true},{"name":"Todd C. Lee","is_ca":true},{"name":"Emily G. McDonald","is_ca":true},{"name":"Mona Bafadhel","is_ca":false},{"name":"Christopher Butler","is_ca":false},{"name":"Josue Rodrigues Silva","is_ca":false},{"name":"Mark Dybul","is_ca":false},{"name":"Edward J. Mills","is_ca":true},{"name":"D. William Cameron","is_ca":false},{"name":"James Orbinski","is_ca":false},{"name":"Sonal Singh","is_ca":false},{"name":"Kristian Thorlund","is_ca":false},{"name":"Jonas Häggström","is_ca":false},{"name":"Heloísa A. Costa","is_ca":false},{"name":"Nayara S. Drumont","is_ca":false},{"name":"Stephanny Kelvyn Bessa","is_ca":false},{"name":"João V.B. Vieira","is_ca":false},{"name":"Vania R Campos","is_ca":false},{"name":"Lineria HM Suterio","is_ca":false},{"name":"Adelino de Melo Freire Júnior","is_ca":false},{"name":"Ana Carolina Fialho Dias Rocha","is_ca":false},{"name":"Ana Paula de Faria Gonçalves","is_ca":false},{"name":"Andressa França","is_ca":false},{"name":"Carlos Eduardo Dias Igídio","is_ca":false},{"name":"Igor César de Oliveira Sousa","is_ca":false},{"name":"Iracema Luisa Quintino de Carvalho","is_ca":false},{"name":"Larissa Maria Manini Benavides","is_ca":false},{"name":"Patrícia de Oliveira Pereira","is_ca":false},{"name":"Phelipy Marques de Sousa","is_ca":false},{"name":"Sabrina de Almeida Lima","is_ca":false},{"name":"Silvia Helena Sousa Pietra Pedroso","is_ca":false},{"name":"Snaydia Viegas Resende","is_ca":false},{"name":"Wellington da Silva Rocha","is_ca":false},{"name":"Thamiris Caldeira Alves","is_ca":false},{"name":"Aline Lúcia de Jesus Martins","is_ca":false},{"name":"Amanda Gouvêa Mesquita","is_ca":false},{"name":"Amanda Larissa Alves Mendes","is_ca":false},{"name":"Anna Beatriz Oliveira Mendes","is_ca":false},{"name":"Anna Clara de Jesus Oliveira","is_ca":false},{"name":"Carolina Couto de Azevedo Cysne","is_ca":false},{"name":"Clara Bensemann Gontijo Pereira","is_ca":false},{"name":"Cecília Campos Siqueira","is_ca":false},{"name":"Ednilson Barbosa Dias","is_ca":false},{"name":"Emanuelle Cristina Soares Gonçalves","is_ca":false},{"name":"Fernanda Leal Guimarães","is_ca":false},{"name":"Flavio E Giorgeto","is_ca":false},{"name":"Gabriel Torga Saade Rodrigues","is_ca":false},{"name":"Gislânia Neres de Sousa","is_ca":false},{"name":"Júlia Campos de Rezende","is_ca":false},{"name":"Júlia Diniz Assis Moreira","is_ca":false},{"name":"Isabela Canabrava Soares","is_ca":false},{"name":"João Victor Barbosa Silveira","is_ca":false},{"name":"Joselaine Gomes de Souza","is_ca":false},{"name":"Juliana Marques Santos Ferreira","is_ca":false},{"name":"Kênia Sthéfhane Guimarães Gonçalves","is_ca":false},{"name":"Laura Campos Oliveira","is_ca":false},{"name":"Layane Maria de Almeida","is_ca":false},{"name":"Letícia Campos Siqueira","is_ca":false},{"name":"Letícia de Fátimas Costa","is_ca":false},{"name":"Lorena Gabrielle Miranda Maciel","is_ca":false},{"name":"Lorena Giovanna Silva Peixoto","is_ca":false},{"name":"Lorena Mesquita Alves","is_ca":false},{"name":"Luana Rosa Rodrigues","is_ca":false},{"name":"Marcela Luíza Amaral Resende Lara","is_ca":true},{"name":"Luíza Lanna França Reis","is_ca":false},{"name":"M. Horacio","is_ca":false},{"name":"Maria Eduarda Martins Soares","is_ca":false},{"name":"Maria Luiza Magalhães Parreiras","is_ca":false},{"name":"Mariana Cristina Flores Mariano","is_ca":false},{"name":"Marina Guimarães Bragatto","is_ca":false},{"name":"Matheus Andrade Almeida e Silva","is_ca":false},{"name":"Mayra Estefane Silva dos Santos","is_ca":false},{"name":"Mirele Augusta Batista Ribeiro","is_ca":false},{"name":"Nayara Santos Drumond","is_ca":false},{"name":"Pedro Hosken Fernandes Guimarães","is_ca":false},{"name":"Pollyana Maria Silva Diniz","is_ca":false},{"name":"Roberta Dumont Paiva Lopes","is_ca":false},{"name":"Sheila Soares Anselmo","is_ca":false},{"name":"Tainara Silva Vieira","is_ca":false},{"name":"Tatiana Aparecida Gomes da Silva","is_ca":false},{"name":"Thais Campos Siqueira","is_ca":false},{"name":"Vânia Regina Carmo","is_ca":false},{"name":"Vitor Augusto Lima do Vale","is_ca":false},{"name":"Vitor Vilaça Oliveira","is_ca":false},{"name":"Wedsley Sander Lopes dos Santos","is_ca":false},{"name":"Aline Daniele de Almeida Abreu","is_ca":false},{"name":"Bernardo Saraiva Resende de Camargos","is_ca":false},{"name":"Camila Araújo Heringer","is_ca":false},{"name":"Daniel Jacinto Mendonça Filho","is_ca":false},{"name":"Eriane Damasia Faria de Almeida Abreu","is_ca":false},{"name":"Felipe augusto Pereira Barnabé","is_ca":false},{"name":"Felipe Alves Vieira","is_ca":false},{"name":"Gabriella Fagundes Carvalho","is_ca":false},{"name":"Higor Gomes Mussi","is_ca":false},{"name":"Hilton Cardoso Arruda Macedo","is_ca":false},{"name":"Igor Bernardes Caciquinho","is_ca":false},{"name":"João Pedro Ribeiro Santos","is_ca":false},{"name":"João Ricardo Garcia Costa","is_ca":false},{"name":"José Lauro Guimarães Cardoso","is_ca":false},{"name":"Júlia Berlim de Abreu","is_ca":false},{"name":"Lorena Rodrigues de Carvalho","is_ca":false},{"name":"Lorena Amaral de Oliveira","is_ca":false},{"name":"Luana Rocha Oliveira Matos","is_ca":false},{"name":"Marcela Ferreira Brito","is_ca":false},{"name":"Mariana Cavaliere Batista e Silva","is_ca":false},{"name":"Matheus Lucca Ângelo Costa Rodrigues","is_ca":false},{"name":"Mateus de Oliveira Ferreira","is_ca":false},{"name":"Murilo Passinati Perez","is_ca":false},{"name":"Natalia Batista Zanetti","is_ca":false},{"name":"Rafaela Ribeiro de Almeida","is_ca":false},{"name":"Sarah Jeniffer da Silva Jamar","is_ca":false},{"name":"Sofia Caporalli Barbosa","is_ca":false},{"name":"Sofia Vianna von Bentzeen Rios","is_ca":false},{"name":"Stella Silva Rosa","is_ca":false},{"name":"Thomaz Takashi Ferreira Morimoto","is_ca":false},{"name":"Verônica de Araújo Libânio costa","is_ca":false},{"name":"Vitor Augusto Alves da Silva","is_ca":false},{"name":"Amanda Cypestre Alves Batista","is_ca":false},{"name":"Ana Flávia Gomes Viana","is_ca":false},{"name":"Ângela Rodrigues Vieira Santos","is_ca":false},{"name":"Anna Luiza Ribeiro Flores","is_ca":false},{"name":"Arthur Guimarães Rodrigues Dutra","is_ca":false},{"name":"Bruna Luiza Maia","is_ca":false},{"name":"Clarisse Lourdes Nadú de Almeida","is_ca":false},{"name":"Daniel Domingues Barbosa","is_ca":false},{"name":"Daniela Medeiros","is_ca":false},{"name":"D Silva","is_ca":false},{"name":"Diuly Ane Faria Rezende","is_ca":false},{"name":"Felipe Menezes Andrade","is_ca":false},{"name":"Fernanda Rúbia Batista","is_ca":true},{"name":"Gabriela Ferreira Reis","is_ca":true},{"name":"Giovane Carvalho Constantino Ferreira de Paula","is_ca":false},{"name":"Geovani de Araújo Júnior","is_ca":false},{"name":"Henrique Amaral Fonseca Pires","is_ca":false},{"name":"Jéssica Aguilar da Silva","is_ca":false},{"name":"Isabela Lovatti Rovetta","is_ca":false},{"name":"Júlia Silva Rangel","is_ca":true},{"name":"Julia Lima Soares de Paula","is_ca":false},{"name":"Juliana de Oliveira Costa","is_ca":false},{"name":"Lucas Júnio da Silva","is_ca":false},{"name":"Luis Gustavo Fernandes Dias","is_ca":false},{"name":"Lívia Francino Oliveira","is_ca":false},{"name":"Lucas Rodrigues Pereira Barros","is_ca":false},{"name":"Lucas de Souza Gontijo Pessoa","is_ca":false},{"name":"Lucas Klier Silva","is_ca":false},{"name":"Maria Luísa Lara Lanza Stabile","is_ca":false},{"name":"Mariana da Rocha Assis Pinto","is_ca":false},{"name":"Nicholas Vanzin Cunha","is_ca":false},{"name":"Paloma Álister Vilela da Silva","is_ca":false},{"name":"Rafael Silva Rodrigues Soares","is_ca":false},{"name":"Thais Gomes de Oliveira","is_ca":false},{"name":"Victor Oliveira de Araújo","is_ca":false},{"name":"Wesley Costa Arcanjo","is_ca":false},{"name":"A Vanetti","is_ca":false},{"name":"Ana Carolina Araújo Lage Santos","is_ca":false},{"name":"Ariade Gomes Freitas","is_ca":false},{"name":"Felipe Viana Santos","is_ca":false},{"name":"Fernanda Freitas Pinheiro","is_ca":false},{"name":"Fernanda Perez Rocha","is_ca":false},{"name":"Filipe Viana Santos","is_ca":false},{"name":"Giulia de Jesus Marcolino","is_ca":false},{"name":"Humberto Drumond Filho","is_ca":false},{"name":"Isabela Gontijo Mendonça","is_ca":false},{"name":"Isadora Gomides Faria","is_ca":false},{"name":"José Victor Mendes Milhomem","is_ca":false},{"name":"Larissa Milagres Mol","is_ca":false},{"name":"Letícia de Fátima Costa","is_ca":false},{"name":"Marcelo Bernardes Rocha Júnior","is_ca":false},{"name":"Maria Constancio Miranda","is_ca":false},{"name":"Nathália Euclides Gonçalves","is_ca":false},{"name":"Suzana Cristina Ricco","is_ca":false},{"name":"Thiago Araújo do Nascimento","is_ca":false},{"name":"Amanda Luiza do Espírito Santo Pinheiro","is_ca":false},{"name":"Ana Carolina Matos Ferreira","is_ca":false},{"name":"Ana Luiza Silva Taveira","is_ca":false},{"name":"Bruno Victor de Souza Lima","is_ca":false},{"name":"Débora Siqueira Diana","is_ca":false},{"name":"Emanuela Pontes Pereira Silveira","is_ca":false},{"name":"Francisca Lina Campos Gonçalves","is_ca":false},{"name":"Gabriel C. Costa","is_ca":false},{"name":"Geraldo César Barroso de Souza","is_ca":false},{"name":"Guilherme Aurelio D'Oliveira Alves","is_ca":false},{"name":"Isadora Luiza Teixeira Neto","is_ca":false},{"name":"Jordanna Porto Inácio","is_ca":false},{"name":"J. Silverio","is_ca":false},{"name":"Lara Silveira Marques","is_ca":false},{"name":"Larissa Martins do Nascimento","is_ca":false},{"name":"Larissa Oliveira Moreira","is_ca":false},{"name":"Lorena Luiza Soares de Oliveira","is_ca":false},{"name":"Lucas Eduardo Lessa Mussi","is_ca":false},{"name":"Lucas Medeiros Ruas","is_ca":false},{"name":"Luiza Nogueira Assis Barbosa","is_ca":false},{"name":"Luiz Otávio de Sousa","is_ca":false},{"name":"Marcelo Rodrigues da Costa Fernandes","is_ca":false},{"name":"Maria Eduarda Guimarães de Souza","is_ca":false},{"name":"Maria Thereza Figueiredo Bélem Calazans","is_ca":false},{"name":"Mariana Rodrigues Marinho de Bastos","is_ca":false},{"name":"Pedro Henrique Arcanjo Alvarenga","is_ca":false},{"name":"Quimberli Vassinave Cujuí","is_ca":false},{"name":"Rafaela Valadares Diniz","is_ca":false},{"name":"Rafael Cota Andrade Ferreira de Souza","is_ca":false},{"name":"Rita de Cássia Silva","is_ca":false},{"name":"Vinícius Alves Corrêa","is_ca":false},{"name":"Vinícius Carvalho de Oliveira","is_ca":false},{"name":"Vitória Aparecida Cunha","is_ca":false},{"name":"Viviane Costa Santos","is_ca":false},{"name":"Ana Paula Figueiredo Guimaraes Almeida","is_ca":false},{"name":"Ana Paula Guimarães Alves de Carvalho","is_ca":false},{"name":"Antônio Henrique Batista Jorge","is_ca":false},{"name":"Artur Pimenta Ribeiro","is_ca":false},{"name":"Elisângela Santos Sena","is_ca":false},{"name":"Cleide Rocha Veloso","is_ca":false},{"name":"Gonçalvino Eleutério Murta","is_ca":false},{"name":"Inara Maria Gomes Cardoso","is_ca":false},{"name":"João Warley Alves","is_ca":false},{"name":"Jorge Fernando Rocha Veloso","is_ca":false},{"name":"Joyce Souto Barbosa Pimenta de Figueiredo","is_ca":false},{"name":"Karolina Campos Sampaio Lopes","is_ca":false},{"name":"Larissa Vieira Souza","is_ca":false},{"name":"Loren Montanha Costa","is_ca":false},{"name":"Ludimila Pereira de Souza","is_ca":false},{"name":"Maria de Fátima César Lima","is_ca":false},{"name":"Maria Izabel Silveira Gonçalves","is_ca":false},{"name":"Marizete Gislaine Mendes","is_ca":false},{"name":"Mayra Darlliane Loiola Silva","is_ca":false},{"name":"Raissa Rocha e Fonseca","is_ca":false},{"name":"Samuel de Oliveira","is_ca":false},{"name":"Thiago Rodrigues Ferro","is_ca":false},{"name":"Ana Carolina Aguiar Estevam","is_ca":false},{"name":"Ana Martins de Oliveira","is_ca":false},{"name":"André Henrique de Sousa Oliveira","is_ca":false},{"name":"Carla Stefany Oliveira França","is_ca":false},{"name":"Hayka K. Rodrigues Freire","is_ca":false},{"name":"Laís Aparecida dos Reis Gama","is_ca":false},{"name":"Laylla Michelle Pereira","is_ca":false},{"name":"Luciléia Alcântara Gomes e Silva","is_ca":false},{"name":"Patrícia Santana Assis","is_ca":false},{"name":"Regiane Aparecida de Andrade","is_ca":false},{"name":"Thaís de Paula Ferreira da Silva","is_ca":false},{"name":"Thiago de Alcântara César","is_ca":false},{"name":"Adriana Marcos Mendes Rabelo","is_ca":false},{"name":"Aline do Carmo Rosa","is_ca":false},{"name":"Ana Paula Vilas Boas Wherberth","is_ca":false},{"name":"André Gustavo Pinto de Souza","is_ca":false},{"name":"André Luiz Souza Gomes","is_ca":false},{"name":"Arthur Henrique Nunes Leite Oliveira","is_ca":false},{"name":"Damiana Rogai Siqueira","is_ca":false},{"name":"Emanuel Peixoto Pinto","is_ca":false},{"name":"Felipe Coelho Soares de Oliveira","is_ca":false},{"name":"Felipe Fraga Damaceno","is_ca":false},{"name":"Guilherme Rhis","is_ca":false},{"name":"Iandra Silva Almeida","is_ca":false},{"name":"Igor Barros de Araújo Borges","is_ca":false},{"name":"Igor Brandão Rocha","is_ca":false},{"name":"Jéssica Genoveva Boline Passarelli Capaz Pinto da Silva","is_ca":false},{"name":"Jorge Carlos do Amaral Júnior","is_ca":false},{"name":"José Pio Marques","is_ca":false},{"name":"Laura Lima Vargas","is_ca":false},{"name":"Lorena Cristina Ferreira Batista","is_ca":false},{"name":"Luiz Eduardo Coelho Fava","is_ca":false},{"name":"Luiza de Azevedo Freitas Giles","is_ca":false},{"name":"Marina Lacerda Marques","is_ca":false},{"name":"Maura Alina Morais Veríssimo","is_ca":true},{"name":"Neila Rodrigues Vargas de Paula","is_ca":false},{"name":"Pâmela de Sousa Dias Demuner","is_ca":false},{"name":"Ramail Santos Pouzas","is_ca":false},{"name":"Roberta Coelho de Marco","is_ca":false},{"name":"Renata Guimarães Siqueira Fernandes","is_ca":false},{"name":"Rita Lopes Mourão","is_ca":false},{"name":"Sabrina Stefany da Silva Souza","is_ca":false},{"name":"Ana Beatriz Amorim","is_ca":false},{"name":"Carolina Francisca Martins","is_ca":false},{"name":"Geovanna Carla Cordeiro","is_ca":false},{"name":"Huisnei Ferreira Lourenço","is_ca":false},{"name":"João Victor Fagundes dos Santos","is_ca":false},{"name":"João Veloso","is_ca":false},{"name":"Júlia Alves Santos","is_ca":false},{"name":"Júlia senra Nogueira","is_ca":false},{"name":"Jussara Carolina Assis Ribeiro Nascimento","is_ca":false},{"name":"Lavínia de Fátima Baldim Martins","is_ca":false},{"name":"Lucca Batista Rocha de Menezes","is_ca":false},{"name":"Mariana das Graças de Aquino Santos","is_ca":false},{"name":"Rafael Augusto de Carvalho Leão","is_ca":false},{"name":"Vitor Franco Moreira","is_ca":false},{"name":"Amanda Diniz Friedmann","is_ca":false},{"name":"Bárbara Carvalho Chaves","is_ca":false},{"name":"Janaína Leyner de Andrade Oliveira","is_ca":false},{"name":"Luiz Felipe de Oliveira Braga","is_ca":false},{"name":"Luiza Gabriele Dutra Duarte","is_ca":false},{"name":"Marcela Julia Rufino Duque","is_ca":false},{"name":"M. Emiliano","is_ca":false},{"name":"Rafaela Carolina Silveira","is_ca":false},{"name":"Virgínia Mara Santos Moreira","is_ca":false},{"name":"Aline Dias Bedetti","is_ca":false},{"name":"Amanda Faria Simoni Campos","is_ca":false},{"name":"Andressa Cartaxo de Almeida","is_ca":false},{"name":"Anna Carolina Motta Costa","is_ca":false},{"name":"Clara Tornelli de Almeida Cunha","is_ca":false},{"name":"Cristiana Silva Mascarenhas","is_ca":false},{"name":"Daniel Ananias da silva","is_ca":false},{"name":"Diana Antoniazzi de Sá Ribeiro","is_ca":false},{"name":"D. Brandão","is_ca":false},{"name":"Érico Henrique Araújo de Morais","is_ca":false},{"name":"Felipe César Soares","is_ca":false},{"name":"Flávia Marcella Sena Gonçalves Borba","is_ca":false},{"name":"Karinna Guimarães Gomes","is_ca":false},{"name":"Marco Wellington Junio Estevam","is_ca":false},{"name":"Matheus Ramos Lopes","is_ca":false},{"name":"Marina Eduarda Santos","is_ca":false},{"name":"Maryane de Oliveira Silva","is_ca":false},{"name":"Nágella Samara Eleutério da Silva","is_ca":false},{"name":"Rafael Rocha Carneir","is_ca":false},{"name":"Rayane Elen Fernandes Silva","is_ca":false},{"name":"Ruan Carling Schott Wondollinger","is_ca":false},{"name":"Yuri Barbosa de Menezes","is_ca":false},{"name":"Bárbara Ellen Souza Rezende","is_ca":false},{"name":"Gabriel Antônio Simões Costa","is_ca":false},{"name":"Gabriel Marcos theodoro Cardoso","is_ca":false},{"name":"Graziela Cesar de Sousa","is_ca":false},{"name":"Graziele Aparecida Silva","is_ca":false},{"name":"Isabela Cristina de Oliveira Campos","is_ca":false},{"name":"Lara Silva Souza","is_ca":false},{"name":"Laura Nacife Rabello","is_ca":false},{"name":"Roberta Ellen Santos Oliveira","is_ca":false},{"name":"Bárbara Nogueira Roberti","is_ca":false},{"name":"Bruno Reis Garcia","is_ca":false},{"name":"Bruno Rocha Gelape","is_ca":false},{"name":"Carina Daniela Lira Moreira Figueiredo","is_ca":false},{"name":"João Vitor Rocha Cachoeira","is_ca":false},{"name":"Júlia Romano Ferreira Santos","is_ca":false},{"name":"Sarah de Resende Silva","is_ca":false},{"name":"Thalita Oliva Rios","is_ca":false},{"name":"Túlio Fonseca e Silva Quadros","is_ca":false},{"name":"Bethany Barber","is_ca":false},{"name":"Camelia Capraru","is_ca":false},{"name":"Camille Lemieux","is_ca":false},{"name":"Daniel Li","is_ca":false},{"name":"David Smookler","is_ca":false},{"name":"Joshua Booth","is_ca":false},{"name":"Magdalena Kuczynski","is_ca":false},{"name":"Maria Kristina Marquez","is_ca":false},{"name":"Seham Noureldin","is_ca":false},{"name":"S Jeganathan","is_ca":false},{"name":"Tharmegan Tharmaratnam","is_ca":false},{"name":"Wesam Aleyadeh","is_ca":false},{"name":"Jeff Powis","is_ca":false},{"name":"Maureen Taylor","is_ca":false},{"name":"Adrienne K. Chan","is_ca":false},{"name":"Elsa Salvant","is_ca":false},{"name":"Christopher J Graham","is_ca":false},{"name":"Marc Dagher","is_ca":false},{"name":"William Parreira Duarte","is_ca":false},{"name":"Duílio de Castro","is_ca":false},{"name":"Flávio Pimenta Silveira","is_ca":false},{"name":"Alber Alípio Ribeiro","is_ca":false},{"name":"Vittorio Medioli","is_ca":false},{"name":"Augusto Viana da Rocha","is_ca":false},{"name":"Hilton Soares de Oliveira","is_ca":false},{"name":"Tânia Maria de Resende Amaral","is_ca":false},{"name":"Christiano Augusto Xavier Pereira","is_ca":false},{"name":"Nádia Cristina Dias Duarte Tomé","is_ca":false},{"name":"João Marcelo Diegues Pereira","is_ca":false},{"name":"Diogo Jonata Ribeiro","is_ca":false},{"name":"Humberto Guimarães Souto","is_ca":false},{"name":"Dulce Pimenta Gonçalves","is_ca":false},{"name":"A. Barcelos","is_ca":false},{"name":"André Luiz Coelho Merlo","is_ca":false},{"name":"Edna Gomes Leite","is_ca":false},{"name":"Caroline Martins Sangali","is_ca":false},{"name":"Angelo Oswaldo de Araujo Santos","is_ca":false},{"name":"Glauciane Resende do Nascimento","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08574649826669666,"gpt":0.4069866918969032,"spread":0.3212401936302066,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021449,0.0004078269,0.001610372,0.0003128045,0.000209572,0.0003625544,0.0004388951,0.0006895032,0.003026698],"category_scores_gemma":[0.001090685,0.0002457183,0.0009230381,0.000207918,0.0003589869,0.0002495036,0.000302638,0.0008529969,0.0002636251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003720513,"about_ca_system_score_gemma":0.0006352905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006049207,"about_ca_topic_score_gemma":0.001365884,"domain_scores_codex":[0.9994418,0.0002764628,0.00005682987,0.0000828296,0.0000717318,0.00007030682],"domain_scores_gemma":[0.9994127,0.0001585904,0.0002139539,0.00002528545,0.00002679216,0.0001627273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7721828,0.01332197,0.008815123,0.004091636,0.00207324,0.0001416956,0.00008416841,0.0006079613,0.0129344,0.0002158683,0.001248378,0.1842827],"study_design_scores_gemma":[0.7246237,0.2349823,0.03296201,0.0004137596,0.001005675,0.0002487042,0.00004533567,0.0006661453,0.001948757,0.0001548837,0.002928657,0.00002006424],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822174,0.01250734,0.0005112374,0.0005400461,0.0002541894,0.002064202,0.00028738,0.0000477821,0.001570432],"genre_scores_gemma":[0.994366,0.00230632,0.001042997,0.0003065627,0.0001703815,0.00118652,0.000156038,0.000003857274,0.0004613804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003026698,"threshold_uncertainty_score":0.01012528,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2333844717","doi":"10.1152/jn.00701.2011","title":"Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole cell recording from CA1 neurons","year":2012,"lang":"en","type":"article","venue":"Journal of Neurophysiology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Heart and Stroke Foundation of Canada","keywords":"Afterhyperpolarization; Dibucaine; Depolarization; Neuroscience; Rheobase; Chemistry; Electrophysiology; Orthodromic; Antidromic; Excitatory postsynaptic potential; Membrane potential; Anesthesia; Medicine; Internal medicine; Inhibitory postsynaptic potential; Biology","authors":[{"name":"Sean H. White","is_ca":true},{"name":"Christine Brisson","is_ca":true},{"name":"R. David Andrew","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02394552728020733,"gpt":0.2498488582121542,"spread":0.2259033309319469,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001209158,0.0002737441,0.0004063706,0.0001540966,0.0002796343,0.000341129,0.0004308741,0.0004428147,0.0009518969],"category_scores_gemma":[0.000148907,0.000152647,0.0002565288,0.0002240339,0.0002881358,0.0004540432,0.0001985475,0.0006755286,0.0001879481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004097456,"about_ca_system_score_gemma":0.0004549189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002772306,"about_ca_topic_score_gemma":0.006287241,"domain_scores_codex":[0.9998591,0.000006565654,0.00001566399,0.00003813579,0.00003843885,0.00004224272],"domain_scores_gemma":[0.9999161,0.00001398341,0.00002407321,0.00001038061,0.00001621649,0.00001924834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722641,0.00002333741,0.0002212541,0.00006278907,0.000007830903,0.00005197673,0.00002807611,0.00003960514,0.9974715,0.00006202247,0.0000281081,0.001831282],"study_design_scores_gemma":[0.00004426992,0.0005605213,0.02270947,0.00001370605,0.00005192928,0.0002869267,0.00008991129,0.001576872,0.9725467,0.00008396814,0.002024614,0.00001113162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895001,0.003008133,0.003663169,0.0001435042,0.00004842309,0.00007148529,0.0006467878,0.0001099649,0.002808357],"genre_scores_gemma":[0.9863417,0.003563318,0.007068941,0.0001564446,0.0000196597,0.0001833225,0.0005521523,0.00003205048,0.002082422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002772306,"threshold_uncertainty_score":0.005512416,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2599156055","doi":"10.1002/mds.26976","title":"Trial of dextromethorphan/quinidine to treat levodopa‐induced dyskinesia in Parkinson's disease","year":2017,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Avanir Pharmaceuticals","keywords":"Dextromethorphan; Quinidine; Dyskinesia; Levodopa; Medicine; Parkinson's disease; Degenerative disease; Anesthesia; Central nervous system disease; Disease; Physical medicine and rehabilitation; Pharmacology; Internal medicine","authors":[{"name":"Susan H. Fox","is_ca":true},{"name":"Leonard Verhagen Metman","is_ca":false},{"name":"John G. Nutt","is_ca":false},{"name":"Matthew Brodsky","is_ca":false},{"name":"Stewart A. Factor","is_ca":false},{"name":"Anthony E. Lang","is_ca":true},{"name":"Laura E. Pope","is_ca":false},{"name":"Nadine Knowles","is_ca":false},{"name":"João Siffert","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02175309167527783,"gpt":0.3169618436053134,"spread":0.2952087519300355,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001552022,0.001438893,0.002893442,0.0004014634,0.0003990516,0.000704643,0.000992467,0.001326715,0.003504604],"category_scores_gemma":[0.001115559,0.0005426516,0.001159758,0.0003246042,0.0009013226,0.0006880308,0.0003559089,0.002047656,0.0006894358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000629902,"about_ca_system_score_gemma":0.001151297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008315643,"about_ca_topic_score_gemma":0.001668513,"domain_scores_codex":[0.9994797,0.0002780402,0.00004567784,0.00007995172,0.00003493838,0.00008182041],"domain_scores_gemma":[0.9993045,0.0001908438,0.00011775,0.00006873144,0.0000704891,0.0002477145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.957808,0.010212,0.0005024835,0.0004794089,0.0005349087,0.00005895742,0.00004986264,0.0002426939,0.008275729,0.00006824299,0.0004072856,0.02136039],"study_design_scores_gemma":[0.7686598,0.2270843,0.002017545,0.00003026749,0.0002246964,0.00005257177,0.00001607705,0.0003091293,0.001121614,0.0000547372,0.0004192757,0.0000100333],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939883,0.00218837,0.0002886846,0.0002952466,0.0002138678,0.001548023,0.000511621,0.00007718085,0.0008886651],"genre_scores_gemma":[0.9936795,0.001319084,0.0007030659,0.0004106465,0.0002085106,0.001573878,0.0008627606,0.00001808234,0.001224411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003504604,"threshold_uncertainty_score":0.01172405,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4316496279","doi":"10.1016/j.cmi.2023.01.010","title":"Efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: a systematic review and meta-analysis","year":2023,"lang":"en","type":"review","venue":"Clinical Microbiology and Infection","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University; University of Ottawa; University of Windsor; Impact; McMaster University; University of Toronto","funders":"Hallym University","keywords":"Medicine; Randomized controlled trial; Observational study; Meta-analysis; Placebo; Internal medicine; Adverse effect; Cochrane Library; Fluvoxamine; Intensive care medicine; Serotonin","authors":[{"name":"Jiawen Deng","is_ca":true},{"name":"Daniel Rayner","is_ca":true},{"name":"Harikrishnaa Ba Ramaraju","is_ca":false},{"name":"Umaima Abbas","is_ca":true},{"name":"Cristian Garcia","is_ca":true},{"name":"Kiyan Heybati","is_ca":false},{"name":"Fangwen Zhou","is_ca":true},{"name":"Emma Huang","is_ca":true},{"name":"Ye‐Jean Park","is_ca":true},{"name":"Myron Moskalyk","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09698994756270174,"gpt":0.4264107263886527,"spread":0.3294207788259509,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00481452,0.00174556,0.0132204,0.002609313,0.0003327004,0.002140596,0.001727921,0.001748067,0.004436966],"category_scores_gemma":[0.0108379,0.0009183707,0.02067419,0.004008477,0.0005083343,0.001280372,0.001201735,0.001500948,0.0003198061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00135248,"about_ca_system_score_gemma":0.002107722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004971059,"about_ca_topic_score_gemma":0.01644317,"domain_scores_codex":[0.9971856,0.0008992618,0.001007943,0.0004203953,0.0003381537,0.0001485727],"domain_scores_gemma":[0.9945928,0.003679555,0.001187777,0.0001463512,0.0003071091,0.00008640462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003616595,0.00005395474,0.004312991,0.5539869,0.4067909,0.0001311587,0.00008955276,0.0005092284,0.0003598076,0.000146662,0.001356761,0.02864553],"study_design_scores_gemma":[0.001487177,0.0003346054,0.006757608,0.03589649,0.9516388,0.0001194803,0.00008110707,0.0001461762,0.0001099306,0.000207665,0.003177147,0.00004389725],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00338353,0.9955059,0.0001829741,0.0001036118,0.0000826938,0.00008456244,0.0004988116,0.00001070249,0.0001471386],"genre_scores_gemma":[0.08832827,0.9083687,0.0009228321,0.0009031533,0.0001857537,0.000258625,0.0007324296,0.00001496845,0.0002852719],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0132204,"threshold_uncertainty_score":0.02546191,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4389989731","doi":"10.1073/pnas.2306090120","title":"Highly specific σ <sub>2</sub> R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; University of North Carolina at Chapel Hill; National Institutes of Health; Welch Foundation","keywords":"Neuropathic pain; Sigma; Finite element method; Ligand (biochemistry); Stress (linguistics); Sigma-1 receptor; Materials science; Receptor; Medicine; Physics; Pharmacology; Internal medicine; Thermodynamics; Philosophy","authors":[{"name":"Muhammad Saad Yousuf","is_ca":false},{"name":"James J. Sahn","is_ca":false},{"name":"Hongfen Yang","is_ca":false},{"name":"Eric T. David","is_ca":false},{"name":"Stephanie Shiers","is_ca":false},{"name":"Marisol Mancilla Moreno","is_ca":false},{"name":"Jonathan Iketem","is_ca":false},{"name":"Danielle M. Royer","is_ca":false},{"name":"Chelsea D. Garcia","is_ca":false},{"name":"Jennifer Zhang","is_ca":false},{"name":"Veronica M. Hong","is_ca":false},{"name":"Subhaan M. Mian","is_ca":false},{"name":"Ayesha Ahmad","is_ca":false},{"name":"Benedict J. Kolber","is_ca":false},{"name":"Daniel J. Liebl","is_ca":false},{"name":"Stephen F. Martin","is_ca":false},{"name":"Theodore J. Price","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02771100162467356,"gpt":0.2795027355302064,"spread":0.2517917339055329,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005693435,0.000267127,0.0002758706,0.000105944,0.00007659932,0.0001273437,0.0001674706,0.0002271289,0.001850906],"category_scores_gemma":[0.00005634926,0.00007825052,0.0001806555,0.00006900894,0.0001476787,0.0001244474,0.0001089893,0.0005213617,0.000400922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001063415,"about_ca_system_score_gemma":0.0001101199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926106,"about_ca_topic_score_gemma":0.0004053838,"domain_scores_codex":[0.999938,0.000008564197,0.000006850737,0.000009564061,0.000016816,0.00002021077],"domain_scores_gemma":[0.9999672,0.000004080205,0.00001308141,0.000003247178,0.000002823436,0.00000947432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002699941,0.00003497198,0.00009130677,0.00003447119,0.000005860607,0.0000413035,0.000004008095,0.00004737624,0.997382,0.00004924339,0.0000641415,0.001975353],"study_design_scores_gemma":[0.00006290482,0.001697506,0.002529819,0.000006594402,0.00001512415,0.0005248241,0.0000238829,0.0002761187,0.9925525,0.00003165479,0.002273299,0.00000570192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942507,0.001492194,0.001867488,0.0001279651,0.00004035693,0.00002310741,0.0004084682,0.0001041676,0.001685662],"genre_scores_gemma":[0.9935963,0.001002589,0.002499877,0.0001089045,0.00001636997,0.00003256023,0.0006475055,0.00001882434,0.002077071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001850906,"threshold_uncertainty_score":0.006191909,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3096009901","doi":"10.1016/j.neuropharm.2020.108360","title":"Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection","year":2020,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Institute of Aging; Priority Academic Program Development of Jiangsu Higher Education Institutions","keywords":"Mitophagy; PINK1; Parkin; MPTP; Substantia nigra; Dopaminergic; Cell biology; Autophagy; Chemistry; Mitochondrion; Agonist; Hydroxydopamine; Pars compacta; Biology; Receptor; Dopamine; Endocrinology; Internal medicine; Biochemistry; Parkinson's disease; Medicine; Apoptosis","authors":[{"name":"Mingmei Wang","is_ca":false},{"name":"Chunlei Wan","is_ca":false},{"name":"Tao He","is_ca":false},{"name":"Chaojun Han","is_ca":false},{"name":"Kailian Zhu","is_ca":false},{"name":"John L. Waddington","is_ca":false},{"name":"Xuechu Zhen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01701926790766184,"gpt":0.2520848160227725,"spread":0.2350655481151107,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674434,0.0003173786,0.000284032,0.0002197178,0.0001820893,0.0003311343,0.0001943263,0.0003437584,0.001625731],"category_scores_gemma":[0.0001061801,0.0001738136,0.0004456658,0.00009574174,0.0002293623,0.000257649,0.0002174244,0.0005043138,0.0003253254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003238462,"about_ca_system_score_gemma":0.0002016484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008835302,"about_ca_topic_score_gemma":0.001693452,"domain_scores_codex":[0.9999155,0.0000150992,0.000008240432,0.00001432074,0.00001448875,0.00003230887],"domain_scores_gemma":[0.9998935,0.000009629696,0.00003638482,0.00001040972,0.00001604508,0.00003401158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005033233,0.00001721509,0.0005897499,0.00004216896,0.00001435754,0.0001040835,0.0000153235,0.0000327172,0.997157,0.0002693397,0.00004696321,0.001207795],"study_design_scores_gemma":[0.00006948701,0.0009249167,0.07699993,0.0000433837,0.0000852406,0.0008160478,0.0002522887,0.001294852,0.9169419,0.0005540302,0.001996426,0.00002146715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905795,0.005722472,0.001901778,0.0003083805,0.0000413934,0.00000923639,0.0002983886,0.00005970264,0.001079056],"genre_scores_gemma":[0.9945962,0.001803082,0.0007335845,0.00005998052,0.00001120186,0.000009109503,0.0002502671,0.00001199736,0.002524733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625731,"threshold_uncertainty_score":0.005438566,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2085854123","doi":"10.1159/000376549","title":"Sigma-1 and N-Methyl-&lt;smlcap&gt;D&lt;/smlcap&gt;-Aspartate Receptors: A Partnership with Beneficial Outcomes","year":2015,"lang":"en","type":"article","venue":"Complex Psychiatry","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Neuroprotection; Excitotoxicity; NMDA receptor; Neuroscience; Receptor; Synaptic plasticity; Nitric oxide; Cell biology; Chemistry; Biology; Pharmacology; Biochemistry; Endocrinology","authors":[{"name":"Mohan Pabba","is_ca":true},{"name":"Etienne Sibille","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03856009981062067,"gpt":0.2992505438693203,"spread":0.2606904440586996,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002359009,0.0004469054,0.0003363647,0.0002233697,0.0001436204,0.0004461954,0.0002207903,0.0003704032,0.001787418],"category_scores_gemma":[0.0001241834,0.00007636585,0.000284999,0.0001973842,0.0002623834,0.0002763083,0.0003831215,0.0003993157,0.0003142707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003731224,"about_ca_system_score_gemma":0.0004704287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006038233,"about_ca_topic_score_gemma":0.001609095,"domain_scores_codex":[0.999869,0.00003009064,0.00001677399,0.00001631288,0.00003225922,0.00003551751],"domain_scores_gemma":[0.9999123,0.000007112635,0.00002744505,0.000005466422,0.00001588371,0.00003190508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002782858,0.0002117625,0.003801953,0.002048826,0.0001883609,0.001512441,0.0002063125,0.0003822259,0.8139714,0.0102076,0.002339786,0.1623464],"study_design_scores_gemma":[0.0004710744,0.006626257,0.0627083,0.0005994464,0.0006188316,0.006026877,0.0009163535,0.001357215,0.7472861,0.01432634,0.158976,0.00008729354],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6244944,0.3406796,0.008460497,0.006010344,0.0004570844,0.00009038449,0.000829821,0.0002672723,0.01871052],"genre_scores_gemma":[0.8685581,0.1182659,0.003631942,0.0009223131,0.0002016659,0.00007063212,0.0004167422,0.00002003504,0.007912524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787418,"threshold_uncertainty_score":0.005979538,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4285729443","doi":"10.1021/acs.jmedchem.2c00582","title":"Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministero della Salute; Natural Sciences and Engineering Research Council of Canada; Università di Pisa; GlaxoSmithKline","keywords":"Chemistry; Allosteric regulation; G protein-coupled receptor; Functional selectivity; Receptor; Ligand (biochemistry); Allosteric modulator; Stereochemistry; Pharmacology; Biochemistry; Biology","authors":[{"name":"Francesca Gado","is_ca":false},{"name":"Rebecca Ferrisi","is_ca":false},{"name":"Beatrice Polini","is_ca":false},{"name":"Kawthar A. Mohamed","is_ca":true},{"name":"Caterina Ricardi","is_ca":false},{"name":"Elena Lucarini","is_ca":false},{"name":"Sara Carpi","is_ca":false},{"name":"Federica Domenichini","is_ca":false},{"name":"Lesley Stevenson","is_ca":false},{"name":"Simona Rapposelli","is_ca":false},{"name":"Giuseppe Saccomanni","is_ca":false},{"name":"Paola Nieri","is_ca":false},{"name":"Gabriella Ortore","is_ca":false},{"name":"Roger G. Pertwee","is_ca":false},{"name":"Carla Ghelardini","is_ca":false},{"name":"Lorenzo Di Cesare Mannelli","is_ca":false},{"name":"Grazia Chiellini","is_ca":false},{"name":"Robert B. Laprairie","is_ca":true},{"name":"Clementina Manera","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02372931291003973,"gpt":0.2651181968481776,"spread":0.2413888839381379,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002064028,0.0004121763,0.0003850031,0.000236005,0.0001781931,0.0004467444,0.0003557815,0.0002451579,0.002520886],"category_scores_gemma":[0.0001189796,0.0001561356,0.0002583308,0.0002525445,0.0001484629,0.0002685197,0.0002864117,0.0005801338,0.0006058706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003444836,"about_ca_system_score_gemma":0.0002993825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007355767,"about_ca_topic_score_gemma":0.002645559,"domain_scores_codex":[0.9999348,0.00001160214,0.000005466712,0.00001424102,0.00001410725,0.00001978411],"domain_scores_gemma":[0.9999639,0.000003483103,0.000008625377,0.000003869877,0.000009011421,0.00001110303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009255302,0.0004948637,0.0003696178,0.0005510068,0.00006265051,0.0002260734,0.00009694603,0.007166065,0.9425826,0.002269493,0.001353687,0.04390135],"study_design_scores_gemma":[0.0007969499,0.004344602,0.001710233,0.00006586004,0.0002160634,0.000776226,0.0001134012,0.0148531,0.9493657,0.0008509161,0.02682925,0.00007770443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429541,0.01296585,0.03037468,0.000674261,0.0001398607,0.0006641982,0.00155335,0.0003940897,0.01027963],"genre_scores_gemma":[0.9603748,0.007234905,0.02317405,0.0003449124,0.00002205235,0.0002742755,0.0009281168,0.0000779231,0.007568881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002520886,"threshold_uncertainty_score":0.008433223,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3096226745","doi":"10.3233/jhd-200440","title":"Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study","year":2020,"lang":"en","type":"article","venue":"Journal of Huntington s Disease","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Pride; Huntington's disease; Psychology; Stage (stratigraphy); Gerontology; Medicine; Internal medicine; Disease; Biology; Political science","authors":[{"name":"Andrew McGarry","is_ca":false},{"name":"Mika Leinonen","is_ca":false},{"name":"Karl Kieburtz","is_ca":false},{"name":"Michal Geva","is_ca":false},{"name":"C. Warren Olanow","is_ca":false},{"name":"Michael R. Hayden","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04894755235556672,"gpt":0.2791275053475795,"spread":0.2301799529920127,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004256244,0.0005480361,0.00136356,0.0001659774,0.0003158504,0.0006539757,0.0005108108,0.0007396702,0.00167572],"category_scores_gemma":[0.00378254,0.0002104682,0.001273823,0.0001894759,0.0002078867,0.0002742833,0.0005077614,0.001117768,0.0002224802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171103,"about_ca_system_score_gemma":0.0003646535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006317791,"about_ca_topic_score_gemma":0.001352395,"domain_scores_codex":[0.9989957,0.0005573283,0.00008086186,0.000144348,0.0001382871,0.00008351291],"domain_scores_gemma":[0.9974952,0.00077376,0.0005934418,0.0003381766,0.0003095187,0.0004899091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5979447,0.007054173,0.2765097,0.001412831,0.008909719,0.0004821334,0.0007053436,0.0008136255,0.01400026,0.000163058,0.002085757,0.08991864],"study_design_scores_gemma":[0.02785497,0.08725267,0.8720375,0.0001523723,0.005970378,0.0004405759,0.0001524309,0.001026081,0.002321688,0.0002511816,0.002467779,0.00007238302],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960569,0.001952463,0.0003256471,0.0000796448,0.00003868872,0.0001575685,0.0007820969,0.00001324765,0.0005937038],"genre_scores_gemma":[0.9969024,0.0004964919,0.0005597952,0.0001319099,0.00004559334,0.0002205624,0.001209041,0.000006397267,0.000427664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004256244,"threshold_uncertainty_score":0.02250946,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}