{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":428,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":428,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"22ca1e3de29e","filters":{"topic":"Phosphodiesterase function and regulation"}},"results":[{"id":"W1972029787","doi":"10.1038/nrd4228","title":"Advances in targeting cyclic nucleotide phosphodiesterases","year":2014,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":769,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cyclic nucleotide; Phosphodiesterase; Cyclic nucleotide phosphodiesterase; Nucleotide; Compartmentalization (fire protection); cGMP-specific phosphodiesterase type 5; Signalling; Pharmacology; Signal transduction; Biology; Intracellular; Medicine; Cell biology; Biochemistry; Erectile dysfunction; Enzyme; Internal medicine; Gene","authors":[{"name":"Donald H. Maurice","is_ca":true},{"name":"Hengming Ke","is_ca":false},{"name":"Faiyaz Ahmad","is_ca":false},{"name":"Yousheng Wang","is_ca":false},{"name":"Jay H. Chung","is_ca":false},{"name":"Vincent C. Manganiello","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009515156501613995,"gpt":0.3152611343199794,"spread":0.3057459778183654,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008297295,0.001110464,0.001571104,0.001550947,0.0002178493,0.001057581,0.001004728,0.001039186,0.002996754],"category_scores_gemma":[0.0007809976,0.000349968,0.0005192358,0.001698287,0.0006089221,0.001376842,0.0009620655,0.002412148,0.001889218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007075813,"about_ca_system_score_gemma":0.0008782173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007588349,"about_ca_topic_score_gemma":0.001872586,"domain_scores_codex":[0.9997934,0.00002764125,0.00001737658,0.00003209987,0.00009252044,0.00003700378],"domain_scores_gemma":[0.9997563,0.0001036009,0.00003215754,0.00001022186,0.00006418827,0.00003343973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001037681,0.00008432625,0.000145975,0.009108026,0.0001006206,0.0002396495,0.00003034908,0.0007980267,0.008360828,0.006609004,0.03498567,0.9394338],"study_design_scores_gemma":[0.00004427229,0.000104883,0.0004079331,0.000977151,0.0001324554,0.0007166464,0.0000226988,0.0002513421,0.002074771,0.003026539,0.9922206,0.00002069503],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002557287,0.9963954,0.0008994657,0.0005532149,0.0003527629,0.000008735647,0.00003178274,0.00002263125,0.001480285],"genre_scores_gemma":[0.001402403,0.9964167,0.0005758213,0.0004188714,0.0002211971,0.000009491869,0.00004692092,0.000003034165,0.0009055442],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002996754,"threshold_uncertainty_score":0.01002508,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2119856466","doi":"10.1016/j.neuron.2007.04.015","title":"Behavioral Phenotypes of Disc1 Missense Mutations in Mice","year":2007,"lang":"en","type":"article","venue":"Neuron","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":533,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Medical Research Council Canada; Ministry of Education, Culture, Sports, Science and Technology","keywords":"DISC1; Missense mutation; Prepulse inhibition; Rolipram; Mutant; Mutation; Antidepressant; Phenotype; Schizophrenia (object-oriented programming); Pharmacology; Genetics; Psychology; Biology; Psychiatry; Neuroscience; Phosphodiesterase; Gene; Hippocampus; Biochemistry","authors":[{"name":"Steven J. Clapcote","is_ca":true},{"name":"Tatiana V. Lipina","is_ca":true},{"name":"J. Kirsty Millar","is_ca":false},{"name":"Shaun Mackie","is_ca":false},{"name":"Sheila Christie","is_ca":false},{"name":"Fumiaki Ogawa","is_ca":false},{"name":"Jason P. Lerch","is_ca":true},{"name":"Keith Trimble","is_ca":true},{"name":"Masashi Uchiyama","is_ca":false},{"name":"Yoshiyuki Sakuraba","is_ca":false},{"name":"Hideki Kaneda","is_ca":false},{"name":"Toshihiko Shiroishi","is_ca":false},{"name":"Miles D. Houslay","is_ca":false},{"name":"R. Mark Henkelman","is_ca":true},{"name":"John G. Sled","is_ca":true},{"name":"Yoichi Gondo","is_ca":false},{"name":"David J. Porteous","is_ca":false},{"name":"John Roder","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01239296755370314,"gpt":0.2768170665710217,"spread":0.2644240990173186,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000300372,0.002588378,0.0007986577,0.003785249,0.0006491894,0.0006897449,0.0008437246,0.001664674,0.006143025],"category_scores_gemma":[0.0005172014,0.000782263,0.0007589626,0.0007781753,0.00173631,0.0003859357,0.001201878,0.001985763,0.001227133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009549501,"about_ca_system_score_gemma":0.000453406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002464003,"about_ca_topic_score_gemma":0.004025171,"domain_scores_codex":[0.9992694,0.00007747851,0.0001125629,0.0002116038,0.0002240451,0.0001048762],"domain_scores_gemma":[0.9990345,0.0001601119,0.0003685809,0.00005624806,0.00005455608,0.0003259879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003330038,0.00007470159,0.0006788816,0.0000622398,0.00002806403,0.001195007,0.00006588451,0.0001673471,0.9955441,0.0002365503,0.0002235565,0.001390719],"study_design_scores_gemma":[0.0002534546,0.0005410507,0.04312637,0.0001145801,0.0002872551,0.0129729,0.0003758766,0.001825108,0.9359158,0.0005032818,0.003999685,0.00008447959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842883,0.001656895,0.00353898,0.0006061535,0.0001953813,0.00007402673,0.004313102,0.0006898514,0.004637376],"genre_scores_gemma":[0.9730814,0.001903845,0.004840518,0.0004683507,0.00007903538,0.0001601267,0.003249553,0.0006308905,0.01558629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006143025,"threshold_uncertainty_score":0.02055049,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2014500068","doi":"10.1161/circulationaha.106.655266","title":"Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility","year":2007,"lang":"en","type":"article","venue":"Circulation","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":528,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; University of Alberta; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Contractility; Medicine; Sildenafil; Internal medicine; Ventricle; Pulmonary hypertension; Phosphodiesterase 3; cGMP-specific phosphodiesterase type 5; Amrinone; Afterload; Cardiology; Inotrope; Endocrinology; Phosphodiesterase; Protein kinase A; Kinase; Chemistry; Biology; Cell biology","authors":[{"name":"Jayan Nagendran","is_ca":false},{"name":"Stephen L. Archer","is_ca":false},{"name":"Daniel Soliman","is_ca":false},{"name":"Vikram Gurtu","is_ca":false},{"name":"Rohit Moudgil","is_ca":false},{"name":"Alois Haromy","is_ca":false},{"name":"Chantal St. Aubin","is_ca":false},{"name":"Linda Webster","is_ca":false},{"name":"Ivan M. Rebeyka","is_ca":false},{"name":"David B. Ross","is_ca":false},{"name":"Peter E. Light","is_ca":false},{"name":"Jason R.B. Dyck","is_ca":false},{"name":"Evangelos D. Michelakis","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01102074681232692,"gpt":0.257599014830393,"spread":0.2465782680180661,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576302,0.0001972345,0.00023019,0.000155468,0.0001014277,0.0001658593,0.00008562367,0.000180073,0.001244942],"category_scores_gemma":[0.0001585588,0.0001087245,0.0001421005,0.00009762432,0.0002459869,0.00009198635,0.0001258394,0.0002374536,0.0002270919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009590815,"about_ca_system_score_gemma":0.0000823417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002565097,"about_ca_topic_score_gemma":0.000328206,"domain_scores_codex":[0.9998902,0.00001521862,0.00001093764,0.00003765304,0.00002907865,0.00001680632],"domain_scores_gemma":[0.9998982,0.00002182913,0.00003992072,0.000008526475,0.000007423637,0.00002412743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003449008,0.0000225162,0.01390343,0.00009278033,0.00002699727,0.0005709436,0.00004118756,0.00004285603,0.9793738,0.00004702627,0.00009419649,0.00543945],"study_design_scores_gemma":[0.00007074478,0.001372294,0.7094979,0.00003837205,0.0001332807,0.007977379,0.0001729007,0.0005550961,0.2767689,0.0001188048,0.003281513,0.00001279549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923524,0.005456275,0.001013631,0.0001080959,0.00003191951,0.00001130677,0.000195461,0.00002441913,0.0008064567],"genre_scores_gemma":[0.9970841,0.001175135,0.0007463919,0.00007243238,0.00004437159,0.000009430567,0.0002967771,0.000006198924,0.0005653211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244942,"threshold_uncertainty_score":0.004164696,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2131727392","doi":"10.1111/bjd.14164","title":"Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate‐to‐severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)","year":2015,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":479,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre de Recherche Dermatologique du Québec Métropolitain; SKiN Health","funders":"Celgene","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Adverse effect; Psoriasis Area and Severity Index; Internal medicine; Dermatology Life Quality Index; Nausea; Randomized controlled trial; Population; Tolerability; Dermatology; Psoriatic arthritis; Pathology; Alternative medicine","authors":[{"name":"C. Paul","is_ca":false},{"name":"Jennifer Clay Cather","is_ca":false},{"name":"Melinda Gooderham","is_ca":true},{"name":"Yves Poulin","is_ca":true},{"name":"Ulrich Mrowietz","is_ca":false},{"name":"J. Crowley","is_ca":false},{"name":"ChiaChi Hu","is_ca":false},{"name":"R.M. Stevens","is_ca":false},{"name":"Kara N. Shah","is_ca":false},{"name":"R. M. Day","is_ca":false},{"name":"Giampiero Girolomoni","is_ca":false},{"name":"A.B. Gottlieb","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007377866692009705,"gpt":0.2451757533723236,"spread":0.2377978866803139,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002836277,0.001361661,0.002416532,0.0003997015,0.0003946465,0.001029819,0.000690787,0.001591566,0.005494689],"category_scores_gemma":[0.001967933,0.0006258672,0.001913786,0.0003585465,0.0008618195,0.0008172779,0.0003057763,0.002294824,0.0007388245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004025347,"about_ca_system_score_gemma":0.0008928929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003285871,"about_ca_topic_score_gemma":0.0007409931,"domain_scores_codex":[0.999212,0.0004444272,0.00006172508,0.0001365069,0.00006966747,0.00007567144],"domain_scores_gemma":[0.9990528,0.0002834021,0.0002672094,0.00006758742,0.00006138447,0.0002676172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9705054,0.007096597,0.000690725,0.0006926644,0.0007142411,0.00003624729,0.00004333651,0.0002101482,0.003630962,0.00006722403,0.0006484925,0.01566404],"study_design_scores_gemma":[0.9582468,0.03948591,0.001392106,0.00002210575,0.0002169737,0.00002816952,0.000007477596,0.000156593,0.0001955276,0.00004028319,0.0002011255,0.000006944203],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859817,0.005736846,0.0005826849,0.0006727478,0.0003648001,0.003952466,0.0008370259,0.0001230325,0.00174862],"genre_scores_gemma":[0.9830766,0.003953832,0.001887868,0.001230893,0.0006078091,0.005740244,0.001149311,0.000025931,0.002327697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005494689,"threshold_uncertainty_score":0.01838154,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2067780273","doi":"10.1038/nature08488","title":"Sleep deprivation impairs cAMP signalling in the hippocampus","year":2009,"lang":"en","type":"article","venue":"Nature","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":470,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Sleep deprivation; Hippocampus; Hippocampal formation; Synaptic plasticity; Sleep (system call); Phosphodiesterase; Neuroscience; Protein kinase A; Neuroscience of sleep; Neuroplasticity; Endocrinology; Psychology; Internal medicine; Biology; Medicine; Circadian rhythm; Kinase; Slow-wave sleep; Enzyme; Cell biology; Electroencephalography; Receptor; Biochemistry","authors":[{"name":"Christopher G. Vecsey","is_ca":false},{"name":"George S. Baillie","is_ca":false},{"name":"Devan Jaganath","is_ca":false},{"name":"Robbert Havekes","is_ca":false},{"name":"Andrew Daniels","is_ca":false},{"name":"Mathieu E. Wimmer","is_ca":false},{"name":"Ted T. Huang","is_ca":false},{"name":"Kim M. Brown","is_ca":false},{"name":"Xiang‐Yao Li","is_ca":true},{"name":"Giannina Descalzi","is_ca":true},{"name":"Susan S. Kim","is_ca":true},{"name":"Tao Chen","is_ca":true},{"name":"Yuze Shang","is_ca":true},{"name":"Min Zhuo","is_ca":true},{"name":"Miles D. Houslay","is_ca":false},{"name":"Ted Abel","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004713799793679765,"gpt":0.235688009734045,"spread":0.2309742099403653,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009327899,0.000380329,0.0004011159,0.0003547102,0.000214011,0.0003617921,0.0003244616,0.0003385906,0.002015437],"category_scores_gemma":[0.0001725819,0.0002824692,0.0003186557,0.0001855917,0.0007622096,0.0004535784,0.000268413,0.0009525475,0.0003140147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006817231,"about_ca_system_score_gemma":0.0007142815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006523705,"about_ca_topic_score_gemma":0.01707454,"domain_scores_codex":[0.9999177,0.000007435417,0.0000104354,0.00001367212,0.00001830609,0.00003233138],"domain_scores_gemma":[0.9998153,0.00002715936,0.00005109054,0.00002839815,0.00001605951,0.00006199468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002724199,0.00004318784,0.0003780563,0.00005102539,0.00002765849,0.0001753037,0.00002614469,0.00006283189,0.9941987,0.0001304862,0.0001914247,0.001990954],"study_design_scores_gemma":[0.0003451955,0.001826214,0.05615823,0.0000280751,0.0001175373,0.0006323439,0.000398422,0.0008905533,0.9364299,0.0008783083,0.002264658,0.00003063478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960801,0.001584888,0.0004240552,0.0004690218,0.0001106629,0.00000909454,0.0005903703,0.00005512145,0.0006767532],"genre_scores_gemma":[0.9947217,0.001405287,0.0003686411,0.0001970723,0.00002359284,0.0000210014,0.0004679998,0.00002989694,0.002764907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006523705,"threshold_uncertainty_score":0.01297146,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2151950207","doi":"10.1164/rccm.200610-1563oc","title":"Effect of 1-Year Treatment with Roflumilast in Severe Chronic Obstructive Pulmonary Disease","year":2007,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":325,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Roflumilast; Medicine; COPD; Exacerbation; Placebo; Bronchodilator; Adverse effect; Internal medicine; Tiotropium bromide; Obstructive lung disease; Pulmonary function testing; Anesthesia; Lung; Lung function; Asthma","authors":[{"name":"Peter M.A. Calverley","is_ca":false},{"name":"Fernando Sánchez-Toril","is_ca":false},{"name":"Andrew McIvor","is_ca":true},{"name":"Peter Teichmann","is_ca":false},{"name":"Dirk Bredenbroeker","is_ca":false},{"name":"Leonardo M. Fabbri","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004791280011951555,"gpt":0.2703169989365715,"spread":0.2655257189246199,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001547311,0.000920247,0.002728177,0.0002990456,0.0004529711,0.0006681675,0.0006082912,0.002153962,0.002723834],"category_scores_gemma":[0.002872475,0.0002856402,0.002068163,0.0002503438,0.0006750933,0.0007450325,0.000404858,0.002074373,0.0003338073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004698289,"about_ca_system_score_gemma":0.0007384236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001393298,"about_ca_topic_score_gemma":0.001997883,"domain_scores_codex":[0.9993603,0.0002987467,0.00005875282,0.00009829998,0.00004730769,0.0001366732],"domain_scores_gemma":[0.9979772,0.0008097343,0.000435179,0.00008969317,0.0000832333,0.0006049568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9493349,0.01176178,0.00377821,0.0006893163,0.0008194101,0.00006210394,0.00005446109,0.0004401098,0.002928704,0.00003595428,0.0005434573,0.0295515],"study_design_scores_gemma":[0.3567796,0.5802886,0.05751505,0.0001651763,0.001794413,0.0001181977,0.00005917066,0.0006571521,0.001476455,0.00009261582,0.001007688,0.00004584474],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903528,0.007633933,0.0001068871,0.0003591603,0.0002807323,0.0002509383,0.0003103164,0.00003007924,0.0006752147],"genre_scores_gemma":[0.9952592,0.002041386,0.0002604602,0.0005703651,0.0003508166,0.0003354521,0.0005178556,0.000004583857,0.000659915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002728177,"threshold_uncertainty_score":0.009112179,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2147812298","doi":"10.1124/mol.64.3.533","title":"Cyclic Nucleotide Phosphodiesterase Activity, Expression, and Targeting in Cells of the Cardiovascular System","year":2003,"lang":"en","type":"review","venue":"Molecular Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":320,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Heart and Stroke Foundation; Queen's University","funders":"","keywords":"Nucleotide; Cyclic nucleotide phosphodiesterase; Cell biology; Effector; Phosphodiesterase; Cyclic nucleotide; Vascular smooth muscle; Biology; Transcription factor; Cell; Motility; Biochemistry; Chemistry; Smooth muscle; Endocrinology; Enzyme; Gene","authors":[{"name":"Donald H. Maurice","is_ca":true},{"name":"Daniel Palmer","is_ca":false},{"name":"Douglas G. Tilley","is_ca":false},{"name":"Heather A. Dunkerley","is_ca":false},{"name":"Stuart J. Netherton","is_ca":false},{"name":"Daniel R. Raymond","is_ca":false},{"name":"Hisham S. Elbatarny","is_ca":false},{"name":"Sandra L. Jimmo","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01196937693629123,"gpt":0.2701154471579879,"spread":0.2581460702216967,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008013151,0.001092146,0.00182253,0.001376389,0.0003242648,0.001183909,0.001520115,0.001481822,0.002045609],"category_scores_gemma":[0.0005947644,0.0004313206,0.0003427233,0.001923153,0.0008107005,0.001351768,0.0005388475,0.001978914,0.002263544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00087675,"about_ca_system_score_gemma":0.001163578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001351272,"about_ca_topic_score_gemma":0.002417482,"domain_scores_codex":[0.9998335,0.00001665563,0.00002107803,0.00003607069,0.00007629614,0.00001641571],"domain_scores_gemma":[0.9997525,0.00008687639,0.00003042461,0.00001210976,0.00008417313,0.00003406676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001539414,0.00008113682,0.0001982376,0.006111063,0.00005355181,0.000375321,0.00005278928,0.0007022808,0.01532079,0.004703358,0.02108554,0.951162],"study_design_scores_gemma":[0.00004390692,0.0001324314,0.001159693,0.001133992,0.0001220565,0.002198234,0.0000684937,0.0002491671,0.004716929,0.003015488,0.9871281,0.00003142312],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003336646,0.9967911,0.0009439524,0.0002743132,0.0003368468,0.000007093503,0.00002404716,0.00001903391,0.001269912],"genre_scores_gemma":[0.001219463,0.9960781,0.0008010278,0.0001922154,0.000221858,0.00001003938,0.00003851394,0.00000274053,0.00143598],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002045609,"threshold_uncertainty_score":0.006843209,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2107034951","doi":"10.1161/01.res.0000261934.56938.38","title":"cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular System","year":2007,"lang":"en","type":"review","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":309,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Medical Research Council; Fondation Leducq; Heart and Stroke Foundation of Canada","keywords":"Phosphodiesterase; Enzyme; Chemistry; Biochemistry; Internal medicine; Endocrinology; Biology; Pharmacology; Medicine","authors":[{"name":"Miles D. Houslay","is_ca":true},{"name":"George S. Baillie","is_ca":true},{"name":"Donald H. Maurice","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1995087198904605,"gpt":0.4108901540509594,"spread":0.211381434160499,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184409,0.0002297445,0.0001773197,0.0004732706,0.0002366824,0.0002979411,0.0002454968,0.0004690966,0.0008376393],"category_scores_gemma":[0.00006812566,0.0001229117,0.0002114831,0.0002358975,0.0003589932,0.0002191926,0.0003187633,0.0005436238,0.000355388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004736323,"about_ca_system_score_gemma":0.0003440106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125071,"about_ca_topic_score_gemma":0.001384261,"domain_scores_codex":[0.99993,0.00001318367,0.000006267754,0.00001942983,0.00001792384,0.00001314803],"domain_scores_gemma":[0.9999714,0.000003709226,0.000006575478,0.000002743447,0.000006539232,0.000008990562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002419965,0.000103388,0.003182455,0.0005835848,0.00004592614,0.001167044,0.0001293384,0.0009051487,0.8908231,0.01237763,0.002002413,0.08843814],"study_design_scores_gemma":[0.0001508101,0.001347574,0.101617,0.000467207,0.0003141556,0.00816281,0.0004718268,0.005070652,0.4721174,0.02191251,0.3882351,0.0001329501],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3345962,0.6008191,0.02208147,0.003989927,0.001128176,0.0001089237,0.0005634982,0.0002654801,0.03644731],"genre_scores_gemma":[0.7849714,0.1717633,0.01652538,0.001008649,0.0006583882,0.00006646518,0.0006292238,0.00001722055,0.02436006],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00125071,"threshold_uncertainty_score":0.003436446,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2130392097","doi":"10.1124/jpet.109.155994","title":"Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"PDE10A; Prepulse inhibition; Pharmacology; Chemistry; Phencyclidine; Phosphodiesterase; NMDA receptor; Schizophrenia (object-oriented programming); Internal medicine; Neuroscience; Psychology; Receptor; Medicine; Biochemistry; Enzyme; Psychiatry","authors":[{"name":"Steven M. Grauer","is_ca":true},{"name":"Virginia Pulito","is_ca":false},{"name":"Rachel L. Navarra","is_ca":false},{"name":"Michy P. Kelly","is_ca":false},{"name":"Cody Kelley","is_ca":false},{"name":"Radka Graf","is_ca":false},{"name":"Barbara Langen","is_ca":false},{"name":"Sheree F. Logue","is_ca":false},{"name":"Julie Brennan","is_ca":false},{"name":"Lixin Jiang","is_ca":false},{"name":"Erik I. Charych","is_ca":false},{"name":"Ute Egerland","is_ca":false},{"name":"Feng Liu","is_ca":false},{"name":"Karen L. Marquis","is_ca":false},{"name":"Michael S. Malamas","is_ca":false},{"name":"Thorsten Hage","is_ca":false},{"name":"Thomas A. Comery","is_ca":false},{"name":"Nicholas J. Brandon","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02185420643969116,"gpt":0.334003919534452,"spread":0.3121497130947608,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004162873,0.0009845856,0.0006784219,0.0008407208,0.0003791506,0.0004325686,0.0005041024,0.0004428019,0.002548683],"category_scores_gemma":[0.0003777742,0.0004868825,0.0004024543,0.0003123626,0.0006205312,0.000459089,0.0001583778,0.00161641,0.0004206372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008514058,"about_ca_system_score_gemma":0.001006813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004012284,"about_ca_topic_score_gemma":0.01041973,"domain_scores_codex":[0.9998622,0.00002794304,0.00001098741,0.00001427288,0.00002911299,0.00005555228],"domain_scores_gemma":[0.9995517,0.00004159731,0.00008807452,0.00002740911,0.00003973833,0.0002515095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02217091,0.005588462,0.001887933,0.0002264589,0.0001742172,0.0002444333,0.0001032755,0.0006999101,0.9510825,0.0006242203,0.001203074,0.01599446],"study_design_scores_gemma":[0.008080096,0.1160212,0.04387771,0.0001202066,0.0007154056,0.001038981,0.0004640667,0.00562825,0.8187658,0.0009936591,0.004183845,0.0001107042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996029,0.001021967,0.0003590616,0.0002902733,0.00005945269,0.00005975047,0.000658891,0.00008025205,0.001441302],"genre_scores_gemma":[0.9943722,0.001639873,0.0004845891,0.00009526091,0.00002453379,0.0000926383,0.0009009549,0.00001560843,0.00237426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004012284,"threshold_uncertainty_score":0.008526206,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2170451911","doi":"10.1172/jci15506","title":"Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development","keywords":"Rolipram; Xylazine; Phosphodiesterase; Pentobarbital; Ketamine; Pharmacology; Endocrinology; Chemistry; Internal medicine; Anesthesia; Medicine; Enzyme; Biochemistry","authors":[{"name":"Annette Robichaud","is_ca":true},{"name":"Panagiota B. Stamatiou","is_ca":true},{"name":"S.-L. Catherine Jin","is_ca":false},{"name":"Nicholas Lachance","is_ca":true},{"name":"Dwight Macdonald","is_ca":true},{"name":"France Laliberté","is_ca":true},{"name":"Susana Liu","is_ca":true},{"name":"Zheng Huang","is_ca":true},{"name":"Marco Conti","is_ca":false},{"name":"Chi‐Chung Chan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05860576188850777,"gpt":0.3252972989974723,"spread":0.2666915371089646,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002927607,0.001215309,0.0005070582,0.001321131,0.0003385318,0.0003803993,0.0005353803,0.0008407751,0.003272088],"category_scores_gemma":[0.0002200801,0.0007088519,0.0008480541,0.0003330869,0.0007634571,0.0004278214,0.000420125,0.001561909,0.0006647301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006163495,"about_ca_system_score_gemma":0.0003987759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009589671,"about_ca_topic_score_gemma":0.001816846,"domain_scores_codex":[0.9995963,0.00005492714,0.00006418406,0.0001327579,0.00006961608,0.00008221089],"domain_scores_gemma":[0.9994987,0.00005316372,0.0002288951,0.00003835913,0.00002424005,0.0001566603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003719401,0.00009679739,0.0002308586,0.00003399156,0.00001285422,0.0001035079,0.00002365018,0.0000639998,0.9979212,0.0001691429,0.00005453532,0.0009174973],"study_design_scores_gemma":[0.0003323184,0.002045512,0.009596914,0.00004159784,0.00009937756,0.001046053,0.0001116792,0.001509023,0.9797086,0.000143477,0.005342149,0.00002330536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872958,0.001227325,0.006610136,0.0003580467,0.0001075964,0.0001659548,0.002291067,0.0003379877,0.001606036],"genre_scores_gemma":[0.9688448,0.00240515,0.01138877,0.0003136866,0.00006253578,0.000505637,0.002889502,0.0003030371,0.01328708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003272088,"threshold_uncertainty_score":0.01094621,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2152248242","doi":"10.1503/jpn.110011","title":"A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health","year":2011,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":241,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false},"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Monoaminergic; Monoamine neurotransmitter; GSK-3; Dopamine; Schizophrenia (object-oriented programming); Neurotransmission; Neuroscience; Protein kinase B; Psychiatry; Psychology; Medicine; Pharmacology; Serotonin; Biology; Signal transduction; Internal medicine; Receptor; Cell biology","authors":[{"name":"Jean‐Martin Beaulieu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01343524184637986,"gpt":0.266352004517791,"spread":0.2529167626714112,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002799245,0.0004670775,0.000252913,0.0004650736,0.0002890597,0.0007645794,0.0002528982,0.000584282,0.001491519],"category_scores_gemma":[0.0001472247,0.0001384199,0.0004390652,0.0003137609,0.0005118842,0.0005021364,0.0005778948,0.001023991,0.0003856522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00048682,"about_ca_system_score_gemma":0.0006419582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008314779,"about_ca_topic_score_gemma":0.001601015,"domain_scores_codex":[0.9998962,0.0000215963,0.000006746855,0.00002532192,0.00001972492,0.00003044521],"domain_scores_gemma":[0.9999197,0.000009395958,0.00002638076,0.000003904232,0.00001237281,0.00002834737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004103219,0.0003512785,0.02363896,0.009191331,0.0007227501,0.003161193,0.001384527,0.002974872,0.3900245,0.08038441,0.02997106,0.4540919],"study_design_scores_gemma":[0.0005749269,0.00258376,0.2275674,0.003053299,0.001115696,0.008418393,0.002442369,0.006692538,0.1386665,0.1083448,0.500231,0.0003092651],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2246177,0.7118844,0.01383002,0.02086051,0.002153892,0.00009677101,0.001010107,0.0003161262,0.02523054],"genre_scores_gemma":[0.5927406,0.3872381,0.00620602,0.002229243,0.0007459097,0.00008256641,0.0006325991,0.00002804539,0.01009692],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001491519,"threshold_uncertainty_score":0.004989624,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1981700374","doi":"10.1002/art.34627","title":"Oral apremilast in the treatment of active psoriatic arthritis: Results of a multicenter, randomized, double‐blind, placebo‐controlled study","year":2012,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Arthritis Research Centre of Canada; Probity Medical Research","funders":"Celgene","keywords":"Apremilast; Medicine; Placebo; Psoriatic arthritis; Internal medicine; Adverse effect; Randomized controlled trial; Rheumatology; Clinical endpoint; Arthritis; Alternative medicine; Pathology","authors":[{"name":"Georg Schett","is_ca":false},{"name":"J. Wollenhaupt","is_ca":false},{"name":"Kim Papp","is_ca":true},{"name":"Rik Joos","is_ca":false},{"name":"J. Rodrigues","is_ca":true},{"name":"Adele R. Vessey","is_ca":false},{"name":"ChiaChi Hu","is_ca":false},{"name":"Randall M. Stevens","is_ca":false},{"name":"Kurt L. de Vlam","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01644179589336447,"gpt":0.2723456008344723,"spread":0.2559038049411079,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006994092,0.00135629,0.004685746,0.0005263775,0.0005876306,0.001073575,0.0009123681,0.002158595,0.00422371],"category_scores_gemma":[0.003684098,0.0007567587,0.001975294,0.0005409286,0.001054461,0.001057701,0.0003170146,0.001650272,0.0005981053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003464088,"about_ca_system_score_gemma":0.001098014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003072096,"about_ca_topic_score_gemma":0.0005209402,"domain_scores_codex":[0.9972906,0.001729189,0.0002598732,0.0002991607,0.00028066,0.0001405023],"domain_scores_gemma":[0.997269,0.00085289,0.0007035467,0.0002166567,0.0003092603,0.0006486644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9473546,0.01389262,0.000666639,0.001441015,0.00161782,0.00005733066,0.00005966195,0.000200744,0.006834264,0.00004261253,0.0004428151,0.02738999],"study_design_scores_gemma":[0.9018819,0.09375332,0.002279887,0.00004840748,0.0008656895,0.00003918807,0.00001131363,0.0001565566,0.0005062522,0.00002528834,0.0004194861,0.0000126501],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634327,0.0247251,0.001790192,0.0008581356,0.001011103,0.005544721,0.0008715158,0.0001947732,0.001571858],"genre_scores_gemma":[0.9763833,0.01106972,0.003112929,0.001275563,0.001814111,0.003911495,0.0008382687,0.00004419481,0.001550375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006994092,"threshold_uncertainty_score":0.03698879,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2053045480","doi":"10.1523/jneurosci.3355-09.2009","title":"Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development","year":2009,"lang":"en","type":"review","venue":"Journal of Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"DISC1; Schizophrenia (object-oriented programming); Disease; Neuroscience; Psychosis; Psychiatry; Psychology; Identification (biology); Brain development; Medicine; Biology; Genetics; Pathology","authors":[{"name":"Nicholas J. Brandon","is_ca":true},{"name":"J. Kirsty Millar","is_ca":false},{"name":"Carsten Korth","is_ca":false},{"name":"Hazel Sive","is_ca":false},{"name":"Karun K. Singh","is_ca":false},{"name":"Akira Sawa","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03988665375593287,"gpt":0.284610229796423,"spread":0.2447235760404902,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005309853,0.000801637,0.001075651,0.001507095,0.0003395807,0.0008533603,0.0009664702,0.001223418,0.002897682],"category_scores_gemma":[0.0006176555,0.0002440399,0.0002761347,0.001475133,0.0005796587,0.001677623,0.0005658616,0.001312955,0.003457197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008860878,"about_ca_system_score_gemma":0.0009246195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206769,"about_ca_topic_score_gemma":0.001873801,"domain_scores_codex":[0.9998791,0.00001722361,0.00001739094,0.00002339457,0.00005038541,0.00001247791],"domain_scores_gemma":[0.9997609,0.00008598149,0.00003496888,0.000009879373,0.00007046133,0.00003787277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009092016,0.00003342839,0.0001841347,0.006660955,0.00003283941,0.0002983558,0.00005666289,0.0002887178,0.002036118,0.004107591,0.02676231,0.959448],"study_design_scores_gemma":[0.00001353241,0.00006025118,0.0008414315,0.001436898,0.00003389805,0.001556385,0.00007512897,0.00006764146,0.0004999429,0.002552314,0.9928496,0.00001297616],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001481206,0.9975305,0.00020067,0.0005394169,0.0002399818,0.00000386523,0.00001488321,0.000007943359,0.001314529],"genre_scores_gemma":[0.0006219168,0.997858,0.0003409404,0.0001614472,0.0001581886,0.000005160239,0.00002462505,0.000001178855,0.0008285559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002897682,"threshold_uncertainty_score":0.009693682,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2120904086","doi":"10.1038/sj.emboj.7601113","title":"An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics","year":2006,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Wellcome Trust; Heart and Stroke Foundation of Canada","keywords":"Biology; Dynamics (music); Cell biology; Computational biology; Biochemistry","authors":[{"name":"Debbie Willoughby","is_ca":false},{"name":"Wei Wong","is_ca":false},{"name":"Jerome Schaack","is_ca":false},{"name":"John D. Scott","is_ca":false},{"name":"Dermot M.F. Cooper","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007785264528340356,"gpt":0.2272546200735815,"spread":0.2194693555452411,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246037,0.0002871277,0.0003154832,0.0002924262,0.0004539782,0.0008141067,0.0006157101,0.0004845114,0.002112279],"category_scores_gemma":[0.0003934109,0.0004225285,0.0002783747,0.0001397837,0.0004540542,0.0009076903,0.0007655174,0.0009804309,0.0007731329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001518672,"about_ca_system_score_gemma":0.0004037213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261033,"about_ca_topic_score_gemma":0.001315571,"domain_scores_codex":[0.9998475,0.00001896897,0.00000872636,0.00003881574,0.00002931139,0.0000566219],"domain_scores_gemma":[0.9998307,0.00003191654,0.00002190362,0.0000258263,0.0000271585,0.00006236817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003172516,0.00001572313,0.0001385996,0.00001749171,0.000004482674,0.00004196411,0.00001386035,0.00005613245,0.998016,0.0007209584,0.00006282898,0.0005945839],"study_design_scores_gemma":[0.00007627276,0.00006763459,0.008730058,0.000005349543,0.00001800139,0.0001617338,0.00007107545,0.005659768,0.9825051,0.000618472,0.002074435,0.00001208507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876553,0.001564412,0.007978746,0.0005090341,0.0001542884,0.00002814079,0.0001974458,0.0002003485,0.001712391],"genre_scores_gemma":[0.992405,0.0003786443,0.003061465,0.0000695421,0.00002698669,0.00001772462,0.0002595014,0.00005175743,0.003729464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002112279,"threshold_uncertainty_score":0.01101875,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2072477505","doi":"10.2174/156800705774322058","title":"CREB, Synapses and Memory Disorders: Past Progress and Future Challenges","year":2005,"lang":"en","type":"review","venue":"Current Drug Targets - CNS & Neurological Disorders","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":186,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"","keywords":"CREB; Neuronal memory allocation; Neuroscience; Long-term potentiation; Aplysia; Synaptic plasticity; Transcription factor; Biology; Neuroplasticity; Cell biology; Metaplasticity; Gene; Genetics; Receptor","authors":[{"name":"Sheena A. Josselyn","is_ca":true},{"name":"Peter Nguyen","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02189130959391541,"gpt":0.2922035506718325,"spread":0.2703122410779171,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008266246,0.0009008654,0.00152628,0.001513274,0.0004166722,0.001095622,0.0010212,0.001918291,0.003534638],"category_scores_gemma":[0.0008570604,0.0002572855,0.0003640011,0.001652685,0.0007919457,0.002416716,0.0007791236,0.001988559,0.002105232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008653846,"about_ca_system_score_gemma":0.001257372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199443,"about_ca_topic_score_gemma":0.002745789,"domain_scores_codex":[0.9998623,0.00003188323,0.00002034499,0.00002312445,0.00004506379,0.00001722734],"domain_scores_gemma":[0.9995155,0.0002461993,0.00003818997,0.00001616163,0.0001123055,0.0000715168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001249814,0.00008521885,0.0001900979,0.008348108,0.0000638948,0.0003308585,0.00008924082,0.0003582817,0.001215315,0.005359847,0.05247351,0.9313607],"study_design_scores_gemma":[0.0000284428,0.0001278756,0.0009030332,0.003091319,0.0000770474,0.001696668,0.0001748218,0.0001197562,0.0003194988,0.007145349,0.9862948,0.00002133368],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005707625,0.9984901,0.0000725869,0.0006986086,0.000244709,0.000001239647,0.000005513877,0.000005175887,0.0004249446],"genre_scores_gemma":[0.0004527248,0.9980277,0.0001691035,0.0003681069,0.0004026112,0.000003329678,0.00001105098,0.000001231127,0.0005641027],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003534638,"threshold_uncertainty_score":0.01182455,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2049374415","doi":"10.1111/odi.12275","title":"Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets","year":2014,"lang":"en","type":"review","venue":"Oral Diseases","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Signal transduction; Phosphodiesterase; Cyclic nucleotide; Cyclic guanosine monophosphate; Biology; Second messenger system; Cell biology; Intracellular; Cyclic adenosine monophosphate; Cell signaling; Nucleotide; Endocrinology; Biochemistry; Receptor; Enzyme; Gene","authors":[{"name":"Faiyaz Ahmad","is_ca":false},{"name":"Tsuyoshi Murata","is_ca":false},{"name":"Kasumi Shimizu","is_ca":false},{"name":"Eva Degerman","is_ca":false},{"name":"Donald H. Maurice","is_ca":true},{"name":"Vincent Manganiello","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01759056802458366,"gpt":0.2897319235886741,"spread":0.2721413555640904,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003887265,0.000605365,0.0006465566,0.0006105042,0.0002373966,0.001159236,0.0004325486,0.0008779278,0.004406518],"category_scores_gemma":[0.0002336784,0.0001557567,0.0002396615,0.0006448403,0.0003403426,0.0008137333,0.0004777774,0.001604892,0.002823103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005464168,"about_ca_system_score_gemma":0.0006238897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003235963,"about_ca_topic_score_gemma":0.0006679453,"domain_scores_codex":[0.999859,0.00002260538,0.00000943719,0.00002482663,0.00004976317,0.00003428228],"domain_scores_gemma":[0.9999069,0.00001120411,0.0000171814,0.000004120941,0.00003060559,0.00002999566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006945363,0.000273757,0.0005163427,0.005066959,0.0000591171,0.0005304425,0.0001077946,0.0005473067,0.08152857,0.01780949,0.06125013,0.8316155],"study_design_scores_gemma":[0.0001710615,0.0004869211,0.001319839,0.000808878,0.00009459636,0.001100673,0.00006997478,0.0004497606,0.01587154,0.00646092,0.9731377,0.00002814346],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003151632,0.9846213,0.001682778,0.003531756,0.001068546,0.00003494134,0.0002961737,0.00008752926,0.005525347],"genre_scores_gemma":[0.02885319,0.9561054,0.002957535,0.002131565,0.001400499,0.0000896881,0.000592684,0.00002635784,0.007843035],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004406518,"threshold_uncertainty_score":0.01474124,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1974790023","doi":"10.1016/j.neuroscience.2003.11.009","title":"Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington′s disease transgenic mice prior to the onset of motor symptoms","year":2004,"lang":"en","type":"article","venue":"Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health","keywords":"Huntington's disease; Phosphodiesterase; Huntingtin; Internal medicine; Striatum; Endocrinology; Genetically modified mouse; Biology; Neurodegeneration; Transgene; Messenger RNA; Medicine; Gene; Disease; Genetics; Dopamine; Biochemistry; Enzyme","authors":[{"name":"Andrea L.O. Hebb","is_ca":true},{"name":"H.A. Robertson","is_ca":true},{"name":"Eileen M. Denovan‐Wright","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01364253601145433,"gpt":0.2455840972528129,"spread":0.2319415612413586,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000110122,0.0004934862,0.0006314077,0.0009166433,0.0003291185,0.0006048644,0.0002960245,0.0007800422,0.002201582],"category_scores_gemma":[0.0001788157,0.0005544202,0.000316155,0.0002490499,0.0006657572,0.0003379111,0.0002202944,0.001443497,0.0004705211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005953106,"about_ca_system_score_gemma":0.0003276374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003163599,"about_ca_topic_score_gemma":0.007238888,"domain_scores_codex":[0.9998329,0.000009148858,0.00001210282,0.00004721358,0.00004866247,0.00004999266],"domain_scores_gemma":[0.9996265,0.00003402877,0.0001504004,0.0000151728,0.00003465872,0.0001392433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002449713,0.00003179552,0.0003703792,0.00001814114,0.000009087468,0.0001793912,0.00003696525,0.000025694,0.9983761,0.0001047269,0.00005285543,0.0005499054],"study_design_scores_gemma":[0.0001001597,0.0004882564,0.08314647,0.00003139377,0.0001111166,0.001661706,0.0002966301,0.0008547163,0.9103274,0.0005204576,0.002430193,0.00003149306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942907,0.001138491,0.001524669,0.0002242293,0.00005720303,0.00001428928,0.001207181,0.0001683813,0.001374839],"genre_scores_gemma":[0.9867258,0.0008973068,0.001527656,0.0001553546,0.00002597865,0.00005811314,0.001538436,0.0001163989,0.008954971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003163599,"threshold_uncertainty_score":0.007365048,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1537435549","doi":"10.1038/ng.3302","title":"PDE3A mutations cause autosomal dominant hypertension with brachydactyly","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation; Mount Sinai Hospital","funders":"Deutsche Hochdruckliga; Deutsche Stiftung für Herzforschung; U.S. Department of Veterans Affairs; Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft; American Heart Association; University of Utah","keywords":"Brachydactyly; Biology; Internal medicine; Endocrinology; Missense mutation; Mutation; Genetics; Medicine; Gene","authors":[{"name":"Philipp G. Maass","is_ca":false},{"name":"Atakan Aydın","is_ca":false},{"name":"Friedrich C. Luft","is_ca":false},{"name":"Carolin Schächterle","is_ca":false},{"name":"Anja Weise","is_ca":false},{"name":"Sigmar Stricker","is_ca":false},{"name":"Carsten Lindschau","is_ca":false},{"name":"Martin Vaegler","is_ca":false},{"name":"Fatimunnisa Qadri","is_ca":false},{"name":"Hakan R. Toka","is_ca":false},{"name":"Herbert Schulz","is_ca":false},{"name":"Peter Krawitz","is_ca":false},{"name":"Dmitri Parkhomchuk","is_ca":false},{"name":"Jochen Hecht","is_ca":false},{"name":"Irene Hollfinger","is_ca":false},{"name":"Yvette Wefeld‐Neuenfeld","is_ca":false},{"name":"Eireen Bartels‐Klein","is_ca":false},{"name":"Astrid Mühl","is_ca":false},{"name":"Martin Kann","is_ca":false},{"name":"Herbert Schuster","is_ca":false},{"name":"David Chitayat","is_ca":true},{"name":"Martin G. Bialer","is_ca":false},{"name":"Thomas F. Wienker","is_ca":false},{"name":"Jürg Ott","is_ca":false},{"name":"Katharina Rittscher","is_ca":false},{"name":"Thomas Liehr","is_ca":false},{"name":"Jens Jordan","is_ca":false},{"name":"Ghislaine Plessis","is_ca":false},{"name":"Jens Tank","is_ca":false},{"name":"Knut Mai","is_ca":false},{"name":"Ramin Naraghi","is_ca":false},{"name":"Russell Hodge","is_ca":false},{"name":"M Hopp","is_ca":false},{"name":"Lars‐Olof Hattenbach","is_ca":false},{"name":"Andreas Busjahn","is_ca":false},{"name":"Anita Rauch","is_ca":false},{"name":"Fabrice Vandeput","is_ca":false},{"name":"Maolian Gong","is_ca":false},{"name":"Franz Rüschendorf","is_ca":false},{"name":"Norbert Hübner","is_ca":false},{"name":"Hermann Haller","is_ca":false},{"name":"Stefan Mundlos","is_ca":false},{"name":"N Bilginturan","is_ca":false},{"name":"Matthew A. Movsesian","is_ca":false},{"name":"Enno Klußmann","is_ca":false},{"name":"Okan Toka","is_ca":false},{"name":"Sylvia Bähring","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01302358554171426,"gpt":0.2480162320357023,"spread":0.234992646493988,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962667,0.001769404,0.0006055803,0.00123683,0.0006419662,0.0004717532,0.0008516533,0.001854175,0.003242793],"category_scores_gemma":[0.0008180747,0.0004813801,0.0009555056,0.0008423738,0.001480654,0.0002680363,0.0009191726,0.00126947,0.0004793356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006589872,"about_ca_system_score_gemma":0.0007175062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004329341,"about_ca_topic_score_gemma":0.007477148,"domain_scores_codex":[0.9995821,0.00003627531,0.00005124301,0.0001222627,0.0001382129,0.00006985624],"domain_scores_gemma":[0.9993943,0.0001506332,0.0002190784,0.00002461346,0.0000210188,0.0001904165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006706622,0.00009461412,0.01928617,0.0001810694,0.0003262436,0.4437728,0.0003776442,0.0008292641,0.5225094,0.002456798,0.002328154,0.007167207],"study_design_scores_gemma":[0.0005769397,0.000289617,0.2156683,0.0001141426,0.0007208869,0.6880832,0.0002943377,0.003484226,0.07722299,0.002895789,0.01045724,0.0001923986],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797741,0.001720023,0.006141623,0.001625443,0.0004235175,0.0000872688,0.002220636,0.000483516,0.007523946],"genre_scores_gemma":[0.9946998,0.0004330836,0.002548969,0.0002792834,0.0001137904,0.00001915415,0.0002577192,0.00008907642,0.001559105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004329341,"threshold_uncertainty_score":0.01084822,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2230518119","doi":"10.2147/copd.s89849","title":"Roflumilast: a review of its use in the treatment of COPD","year":2016,"lang":"en","type":"article","venue":"International Journal of COPD","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute for Health and Care Research; McGill University; Takeda Pharmaceuticals International; Takeda Pharmaceuticals North America","keywords":"COPD; Roflumilast; Chronic bronchitis; Placebo; Systemic inflammation; Bronchitis; Exacerbation; Diabetes mellitus","authors":[],"retraction":null,"screen_n_in":null,"score":{"opus":0.02049438483015831,"gpt":0.2949281682299372,"spread":0.2744337833997789,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007281969,0.0008014205,0.001889531,0.0028754,0.0003475625,0.0009858006,0.001171557,0.001111258,0.004771385],"category_scores_gemma":[0.001320555,0.0002958818,0.001326467,0.002574385,0.0003615223,0.00115596,0.0005638022,0.001719076,0.001565541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000506689,"about_ca_system_score_gemma":0.0009857034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386536,"about_ca_topic_score_gemma":0.002666119,"domain_scores_codex":[0.9996433,0.00007186035,0.00009896293,0.00005664203,0.0001056238,0.00002367342],"domain_scores_gemma":[0.999398,0.000329632,0.00009418408,0.00001265601,0.0001257148,0.0000397718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002145438,0.0001205353,0.0001987247,0.06351521,0.0002573519,0.000305177,0.00009686896,0.000258203,0.001246904,0.001456463,0.03113585,0.9011942],"study_design_scores_gemma":[0.00008639261,0.0003591442,0.001634574,0.02262758,0.000796729,0.002338009,0.00008086694,0.0001316826,0.000349277,0.0009022119,0.9706551,0.00003844215],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000105764,0.998976,0.00006128295,0.0001645108,0.0001787564,0.000009648277,0.00002426993,0.000004765997,0.0004751264],"genre_scores_gemma":[0.0004871962,0.9987094,0.0001361846,0.0002005245,0.0001781049,0.00001306757,0.00003807128,0.000001630927,0.0002357822],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004771385,"threshold_uncertainty_score":0.01596189,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2109143421","doi":"10.1016/s2213-2600(13)70187-5","title":"Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials","year":2013,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Bronchodilator; Asthma; Placebo; COPD; Bronchodilator Agents; Clinical trial; Internal medicine; Pulmonary function testing; Inhalation; Anesthesia","authors":[{"name":"Lui Franciosi","is_ca":true},{"name":"Zuzana Diamant","is_ca":false},{"name":"Katharine H. Banner","is_ca":false},{"name":"Rob Zuiker","is_ca":false},{"name":"Nicoletta Morelli","is_ca":false},{"name":"Ingrid M. C. Kamerling","is_ca":false},{"name":"Marieke L. de Kam","is_ca":false},{"name":"Jacobus Burggraaf","is_ca":false},{"name":"Adam F. Cohen","is_ca":false},{"name":"Mario Cazzola","is_ca":false},{"name":"Luigino Calzetta","is_ca":false},{"name":"Dave Singh","is_ca":false},{"name":"Domenico Spina","is_ca":false},{"name":"Michael Walker","is_ca":true},{"name":"Clive Page","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04435133549590786,"gpt":0.3262270745161338,"spread":0.2818757390202259,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004749573,0.001217427,0.003159011,0.0004018251,0.0004095977,0.001141342,0.0007242078,0.002015958,0.001869928],"category_scores_gemma":[0.003294772,0.0005476379,0.002677998,0.0004550627,0.001075879,0.001025545,0.0003364057,0.002310353,0.0003439519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006783156,"about_ca_system_score_gemma":0.0005824305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009003857,"about_ca_topic_score_gemma":0.001872344,"domain_scores_codex":[0.9984143,0.0008192732,0.0001808408,0.0002595329,0.0001554536,0.0001706608],"domain_scores_gemma":[0.9980464,0.0008751165,0.0004882961,0.0001254003,0.0001425702,0.0003222258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8480018,0.003889474,0.01566468,0.00329822,0.01131826,0.0001997387,0.0002630071,0.0007759465,0.01678551,0.0002320593,0.002120888,0.09745041],"study_design_scores_gemma":[0.640209,0.2265687,0.1012763,0.0004264764,0.01842501,0.0005585607,0.000255265,0.0008498988,0.004549517,0.0005779166,0.006157129,0.0001463126],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330446,0.06020621,0.0004780293,0.001386965,0.0003484147,0.0005602192,0.001187853,0.00006197091,0.002725905],"genre_scores_gemma":[0.9848151,0.01133738,0.0004482508,0.001021547,0.0003477641,0.0002648821,0.0009950548,0.0000127734,0.0007572621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004749573,"threshold_uncertainty_score":0.02511841,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2133704905","doi":"10.1124/mol.104.002246","title":"Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes","year":2004,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Rolipram; Proinflammatory cytokine; Tumor necrosis factor alpha; Molecular biology; T cell; CD8; Monocyte; Chemistry; Biology; Immunology; Phosphodiesterase; Pharmacology; Biochemistry; Immune system; Inflammation; Enzyme","authors":[{"name":"Susan J. Smith","is_ca":false},{"name":"L B Cieslinski","is_ca":false},{"name":"Robert Newton","is_ca":false},{"name":"Louise Donnelly","is_ca":false},{"name":"Peter Fenwick","is_ca":false},{"name":"Andrew G. Nicholson","is_ca":false},{"name":"Peter J. Barnes","is_ca":false},{"name":"Mary S. Barnette","is_ca":false},{"name":"Mark A. Giembycz","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01176628024811817,"gpt":0.3078456498108342,"spread":0.296079369562716,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000281983,0.0003842029,0.0003851218,0.0002316254,0.0001599421,0.0002938692,0.0003932403,0.0004177026,0.00078466],"category_scores_gemma":[0.000161734,0.0002823227,0.0003050359,0.0001143643,0.0001995289,0.0001628264,0.000123295,0.0006071242,0.0004732158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003533158,"about_ca_system_score_gemma":0.0003504388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310807,"about_ca_topic_score_gemma":0.002875931,"domain_scores_codex":[0.9999053,0.00002286025,0.00000495255,0.00001342165,0.00002267526,0.00003069654],"domain_scores_gemma":[0.9999436,0.00001121933,0.00001026407,0.000006290967,0.00001170692,0.00001693238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003688603,0.00006887568,0.0001717003,0.00005620387,0.000009548331,0.0000953898,0.00002107563,0.0001220374,0.9939529,0.0001930495,0.000163337,0.004776985],"study_design_scores_gemma":[0.0001156785,0.001527497,0.002166835,0.00000739134,0.00003976831,0.0004399619,0.0000173009,0.000534532,0.9906535,0.00005153891,0.004440482,0.000005454982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701201,0.01608545,0.007197187,0.0006778114,0.000117949,0.0001510773,0.0006995109,0.0001654437,0.004785439],"genre_scores_gemma":[0.9815242,0.008234357,0.003567822,0.0002129269,0.00007362726,0.00008898404,0.001421401,0.00003027373,0.004846528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310807,"threshold_uncertainty_score":0.002624989,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2049576864","doi":"10.1073/pnas.1004361107","title":"<i>Disrupted-in-schizophrenia</i> 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"DISC1; Mitochondrion; Biology; Function (biology); Cell biology; Gene; Genetics","authors":[{"name":"Young-Un Park","is_ca":false},{"name":"Jae‐Hoon Jeong","is_ca":false},{"name":"Haeryun Lee","is_ca":false},{"name":"Ji Young Mun","is_ca":false},{"name":"Joung‐Hun Kim","is_ca":false},{"name":"Jong Seo Lee","is_ca":false},{"name":"Minh Dang Nguyen","is_ca":true},{"name":"Sung‐Sik Han","is_ca":false},{"name":"Pann‐Ghill Suh","is_ca":false},{"name":"Sang Ki Park","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007618072641979122,"gpt":0.2627245486799226,"spread":0.2551064760379435,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120917,0.0005111614,0.0002177931,0.0002186676,0.0002874572,0.0002961375,0.0001959002,0.0003125428,0.0008577612],"category_scores_gemma":[0.00009972726,0.0000990998,0.000208549,0.0001183786,0.0002667694,0.0001566479,0.0002900184,0.0002875605,0.0003682757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005318522,"about_ca_system_score_gemma":0.0001788038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009956681,"about_ca_topic_score_gemma":0.001419071,"domain_scores_codex":[0.9999231,0.00001287489,0.000008329414,0.00002011537,0.00001584877,0.00001970509],"domain_scores_gemma":[0.9999112,0.000005974668,0.00004467543,0.000006101602,0.000006274842,0.00002576366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111161,0.000007676537,0.001141543,0.00004281212,0.000007261265,0.0003588051,0.00001722142,0.00004872764,0.9967152,0.0002153245,0.0000883524,0.001245917],"study_design_scores_gemma":[0.00002505846,0.0001693495,0.03938653,0.0000252748,0.00004872036,0.004367892,0.00008862941,0.001349731,0.9456822,0.0002521131,0.008590365,0.00001410761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910472,0.002992236,0.00334869,0.0002889117,0.00004912855,0.00001866597,0.0006441862,0.00008864645,0.001522364],"genre_scores_gemma":[0.9948536,0.0008925853,0.002326985,0.00009824456,0.00001077004,0.000009819993,0.0007296402,0.00001777315,0.001060671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009956681,"threshold_uncertainty_score":0.003858864,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2045678725","doi":"10.1016/j.neuron.2010.06.002","title":"Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development","year":2010,"lang":"en","type":"article","venue":"Neuron","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"Regulator; Neuroscience; Embryonic stem cell; DISC1; Master regulator; Embryogenesis; Biology; Cell biology; Embryo; Genetics; Gene; Transcription factor","authors":[{"name":"Karun K. Singh","is_ca":false},{"name":"Xuecai Ge","is_ca":false},{"name":"Yingwei Mao","is_ca":false},{"name":"Laurel Drane","is_ca":false},{"name":"Konstantinos Meletis","is_ca":false},{"name":"Benjamin A. Samuels","is_ca":false},{"name":"Li-Huei Tsai","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006697953802495711,"gpt":0.248242888213289,"spread":0.2415449344107933,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189501,0.0005744436,0.0002839751,0.0004550362,0.0006168672,0.0007344833,0.0004456847,0.0003585035,0.002149296],"category_scores_gemma":[0.0002003011,0.0003014018,0.0001427595,0.0001796776,0.0004090167,0.0003166618,0.0004797552,0.0006149512,0.0006448273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001549412,"about_ca_system_score_gemma":0.0004475479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009509533,"about_ca_topic_score_gemma":0.002410965,"domain_scores_codex":[0.9998702,0.00001206961,0.00001205392,0.00003753659,0.00003650311,0.00003165187],"domain_scores_gemma":[0.9998478,0.00001615488,0.00004498829,0.00001079949,0.00002123138,0.00005915523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001898854,0.000008518596,0.0004252788,0.00005797238,0.000005148743,0.0002283595,0.00001114431,0.000106587,0.9956454,0.0008194708,0.000243357,0.00225892],"study_design_scores_gemma":[0.00001258685,0.00002741437,0.007326812,0.000008361937,0.00001035246,0.0005654575,0.00004779386,0.0007087453,0.9835982,0.0002080627,0.007478567,0.000007793112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478593,0.01801349,0.01539515,0.001220085,0.0003519078,0.00007046967,0.002776328,0.0003075577,0.01400563],"genre_scores_gemma":[0.9824638,0.002212672,0.004486441,0.0001294993,0.00002493406,0.00002330646,0.001795065,0.00005334882,0.008810796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002149296,"threshold_uncertainty_score":0.01124179,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2130370960","doi":"10.1111/j.1476-5381.2011.01524.x","title":"GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses","year":2011,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph","funders":"","keywords":"Rolipram; Hippocampal formation; Pharmacology; Hippocampus; Microdialysis; Medicine; Chemistry; Internal medicine; Central nervous system; Phosphodiesterase; Biochemistry; Enzyme","authors":[{"name":"Olga Bruno","is_ca":false},{"name":"Ernesto Fedele","is_ca":false},{"name":"Jos Prickaerts","is_ca":false},{"name":"Linda A. Parker","is_ca":true},{"name":"Elisa Canepa","is_ca":false},{"name":"Chiara Brullo","is_ca":false},{"name":"Anna Cavallero","is_ca":false},{"name":"Elena Gardella","is_ca":false},{"name":"André Luís Balbi","is_ca":false},{"name":"Cinzia Domenicotti","is_ca":false},{"name":"Eva Bollen","is_ca":false},{"name":"Tim Vanmierlo","is_ca":false},{"name":"Katharina Erb","is_ca":true},{"name":"Cheryl L. Limebeer","is_ca":true},{"name":"Francesca Argellati","is_ca":false},{"name":"Umberto M. Marinari","is_ca":false},{"name":"M.A. Pronzato","is_ca":false},{"name":"Roberta Ricciarelli","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01619061424000145,"gpt":0.2541891841704036,"spread":0.2379985699304022,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109143,0.0005384481,0.0004342526,0.0003071273,0.0001044392,0.0001664693,0.0004260964,0.0004426181,0.001593772],"category_scores_gemma":[0.00008543599,0.0001503486,0.0003357479,0.0001322218,0.0002063597,0.000222904,0.0001190088,0.0008675287,0.0007348435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001528923,"about_ca_system_score_gemma":0.0001557734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003909114,"about_ca_topic_score_gemma":0.0007995295,"domain_scores_codex":[0.9999505,0.000007545879,0.000003489946,0.00001024276,0.00001227831,0.00001599931],"domain_scores_gemma":[0.9999614,0.000003984494,0.00001149495,0.000004228119,0.000006191873,0.00001275512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008948694,0.0003583583,0.0001693625,0.0001964746,0.00003845496,0.0001161259,0.00001530648,0.00012414,0.9862579,0.0001428475,0.0002940316,0.01139207],"study_design_scores_gemma":[0.001644202,0.01555128,0.009665273,0.0000719504,0.00021047,0.001520359,0.00004975676,0.0009270352,0.9550617,0.0001761351,0.01509085,0.00003088133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715747,0.01894048,0.002759681,0.0006933608,0.0001031374,0.0001109747,0.000909763,0.0002783232,0.004629682],"genre_scores_gemma":[0.9732375,0.0130413,0.006233686,0.0004888471,0.00005661618,0.00009189362,0.002106521,0.00004163157,0.004701991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593772,"threshold_uncertainty_score":0.005331695,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2098878066","doi":"10.1161/circresaha.111.300003","title":"Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart","year":2012,"lang":"en","type":"article","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Contractility; Endoplasmic reticulum; Calcium; Phosphodiesterase; ATPase; Cell biology; Basal (medicine); Internal medicine; Endocrinology; Calcium signaling; Calcium ATPase; Chemistry; Ryanodine receptor 2; Biology; Medicine; Enzyme; Biochemistry; Ryanodine receptor","authors":[{"name":"Sanja Beca","is_ca":true},{"name":"Faiyaz Ahmad","is_ca":true},{"name":"Weixing Shen","is_ca":true},{"name":"Jie Liu","is_ca":true},{"name":"Samy Makary","is_ca":true},{"name":"Nazari Polidovitch","is_ca":true},{"name":"Junhui Sun","is_ca":true},{"name":"Steven Hockman","is_ca":true},{"name":"Youn Wook Chung","is_ca":true},{"name":"Matthew A. Movsesian","is_ca":true},{"name":"Elizabeth Murphy","is_ca":true},{"name":"Vincent C. Manganiello","is_ca":true},{"name":"Peter H. Backx","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07719243857453972,"gpt":0.3651227600131259,"spread":0.2879303214385862,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005467425,0.0007537241,0.0004637667,0.0008963977,0.0004674334,0.0006445235,0.0007301453,0.0009262268,0.002086695],"category_scores_gemma":[0.0002352872,0.0006378666,0.0008516261,0.0003296847,0.0008358689,0.0004869669,0.0004611634,0.001318932,0.0008820393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007351016,"about_ca_system_score_gemma":0.0003476741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007725099,"about_ca_topic_score_gemma":0.00141064,"domain_scores_codex":[0.999624,0.0000572423,0.0000481395,0.0001133186,0.00008794869,0.0000693765],"domain_scores_gemma":[0.9995766,0.00004130124,0.0001667939,0.00004756592,0.00002507191,0.0001426464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001913521,0.00003270131,0.0003392224,0.0000412637,0.000006405908,0.00004842893,0.00001654348,0.00003722589,0.9986708,0.0001302883,0.00005165351,0.0004342088],"study_design_scores_gemma":[0.0002292615,0.000481469,0.01962428,0.00005426634,0.00008722406,0.0006050244,0.00009768315,0.002206413,0.972592,0.0002692739,0.003735768,0.00001743482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815845,0.004362706,0.009691195,0.0006191082,0.0001118279,0.0001042159,0.001487329,0.0003944865,0.001644646],"genre_scores_gemma":[0.9824618,0.002168766,0.008951704,0.0002815891,0.00003690807,0.000345313,0.001007096,0.0001493786,0.004597478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002086695,"threshold_uncertainty_score":0.006980717,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2013686136","doi":"10.1016/s0002-9440(10)65087-0","title":"Dextran Sulfate Sodium-Induced Colonic Histopathology, but not Altered Epithelial Ion Transport, Is Reduced by Inhibition of Phosphodiesterase Activity","year":2000,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"Medical Research Council; Crohn's and Colitis Foundation of Canada; Medical Research Council Canada; Crohn's and Colitis Foundation","keywords":"Rolipram; Phosphodiesterase inhibitor; Colitis; Histopathology; Myeloperoxidase; Pentoxifylline; Endocrinology; Internal medicine; Phosphodiesterase; Stimulation; Chemistry; Pharmacology; Medicine; Inflammation; Pathology; Biochemistry","authors":[{"name":"Natalia Diaz-Granados","is_ca":true},{"name":"Kathryn L. Howe","is_ca":true},{"name":"Jun Lü","is_ca":true},{"name":"Derek M. McKay","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00886676170472186,"gpt":0.2396503146237459,"spread":0.2307835529190241,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775707,0.0007812183,0.0006339261,0.0006414787,0.0002312741,0.0004125778,0.0002621561,0.0005937577,0.002563149],"category_scores_gemma":[0.000206648,0.0003434853,0.0004358276,0.0003116445,0.000608699,0.0003475864,0.0002057108,0.001302572,0.000497736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004959173,"about_ca_system_score_gemma":0.0004747108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057669,"about_ca_topic_score_gemma":0.001526828,"domain_scores_codex":[0.9997494,0.00003328712,0.00002236451,0.00004036294,0.00006588972,0.00008863666],"domain_scores_gemma":[0.9994053,0.00005510077,0.0001613707,0.0000751296,0.00004846589,0.0002547557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000545505,0.00005735386,0.0001295179,0.00002543186,0.00000668187,0.00008499607,0.000007785339,0.0000214477,0.9985679,0.00006372618,0.00002976066,0.0004598141],"study_design_scores_gemma":[0.00005904293,0.001145592,0.009469284,0.00000887419,0.00002584731,0.0004912307,0.00004120918,0.0004860824,0.9875158,0.00007139993,0.0006779494,0.000007589621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942529,0.0009095554,0.002301345,0.0003091972,0.0001022691,0.00003287596,0.0003830724,0.0002423262,0.001466409],"genre_scores_gemma":[0.9941419,0.0006466962,0.001383294,0.00006789868,0.00001468918,0.0000242598,0.0004654532,0.00004375995,0.003212024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002563149,"threshold_uncertainty_score":0.008574605,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2043379639","doi":"10.1016/s0028-3908(00)00142-8","title":"PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway","year":2001,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Pharmacology; Neuroscience; Medicine; Chemistry; Biology","authors":[{"name":"Annette Robichaud","is_ca":true},{"name":"Chantal Savoie","is_ca":true},{"name":"Panagiota B. Stamatiou","is_ca":true},{"name":"F.D. Tattersall","is_ca":false},{"name":"C C Chan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01084644182661778,"gpt":0.2522296443340253,"spread":0.2413832025074076,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002463425,0.0006963686,0.0006085362,0.0005110479,0.0002996541,0.0004657195,0.0004707912,0.0006666239,0.002677082],"category_scores_gemma":[0.0004289661,0.0002934509,0.000665293,0.0001156103,0.0007875013,0.0006832285,0.0004475317,0.002170867,0.0004293926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001377787,"about_ca_system_score_gemma":0.0003561699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433552,"about_ca_topic_score_gemma":0.002460746,"domain_scores_codex":[0.9998053,0.00001900998,0.00001435983,0.00003992172,0.00003427698,0.000087156],"domain_scores_gemma":[0.9995881,0.0001329508,0.0000839652,0.00004526676,0.00003349398,0.0001162043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00116909,0.00009794787,0.0001737447,0.00003337091,0.000012611,0.000167006,0.00002632546,0.00006379896,0.9968485,0.0001564714,0.00010435,0.001146713],"study_design_scores_gemma":[0.0001032124,0.0006725014,0.002307487,0.000006347587,0.00002398462,0.0001187405,0.00004640649,0.0004961882,0.9950609,0.0000955066,0.00106324,0.000005545092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992838,0.001361205,0.001778038,0.0006421494,0.0002724783,0.000082502,0.000382624,0.0001640135,0.002479048],"genre_scores_gemma":[0.9857737,0.0007095376,0.001150988,0.0003231986,0.0001099625,0.00009661668,0.0004205957,0.00008068977,0.01133469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002677082,"threshold_uncertainty_score":0.009996593,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2010709967","doi":"10.1016/j.jacc.2013.05.057","title":"Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes","year":2013,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Deutsche Herzstiftung; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; European Commission; Fondation Leducq; Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Internal medicine; Stimulation; Endocrinology; Phosphodiesterase; Medicine; Phosphodiesterase 3; Contractility; Nitric oxide; Cyclic guanosine monophosphate; Nitric oxide synthase; Cyclic adenosine monophosphate; Adrenergic; Receptor; Biology; Enzyme; Biochemistry","authors":[{"name":"Hind Mehel","is_ca":false},{"name":"Julius Emons","is_ca":false},{"name":"Christiane Vettel","is_ca":false},{"name":"Katrin Wittköpper","is_ca":false},{"name":"Danilo Seppelt","is_ca":false},{"name":"Matthias Dewenter","is_ca":false},{"name":"Susanne Lutz","is_ca":false},{"name":"Samuel Sossalla","is_ca":false},{"name":"Lars S. Maier","is_ca":false},{"name":"Patrick Lechêne","is_ca":false},{"name":"Jérôme Leroy","is_ca":false},{"name":"Florence Lefebvre","is_ca":false},{"name":"Audrey Varin","is_ca":false},{"name":"Thomas Eschenhagen","is_ca":false},{"name":"Stanley Nattel","is_ca":true},{"name":"Dobromir Dobrev","is_ca":false},{"name":"Wolfram‐Hubertus Zimmermann","is_ca":false},{"name":"Viacheslav O. Nikolaev","is_ca":false},{"name":"Grégoire Vandecasteele","is_ca":false},{"name":"Rodolphe Fischmeister","is_ca":false},{"name":"Ali El‐Armouche","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00917957540910203,"gpt":0.2497462129980563,"spread":0.2405666375889543,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406158,0.0002606363,0.000409186,0.0003123712,0.0002050919,0.0004227466,0.0001188769,0.0002736379,0.001626641],"category_scores_gemma":[0.0002314694,0.000325941,0.0002822999,0.0002005662,0.0003687596,0.000178575,0.0001799225,0.0005627204,0.000243122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783958,"about_ca_system_score_gemma":0.0001403722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003520115,"about_ca_topic_score_gemma":0.0004702916,"domain_scores_codex":[0.999879,0.00002212856,0.00001167728,0.00003084607,0.00002182748,0.00003456002],"domain_scores_gemma":[0.9998957,0.00002305979,0.00002500771,0.00001595204,0.000006791939,0.00003343715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002574231,0.00007939731,0.003267116,0.00005742531,0.00003271661,0.0006116759,0.00006244209,0.00004682387,0.9914081,0.00008394845,0.0001077541,0.001668443],"study_design_scores_gemma":[0.0004999478,0.002498551,0.2877156,0.00002811629,0.0003077161,0.004590043,0.0005788191,0.001412052,0.6988297,0.0003656475,0.003150638,0.00002311301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977018,0.001212498,0.0003642617,0.00008955151,0.00005214763,0.000008320442,0.000139048,0.00001380064,0.0004185805],"genre_scores_gemma":[0.997573,0.0006188101,0.000353473,0.00009054048,0.00004382061,0.00002607471,0.000279057,0.000009698381,0.001005592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626641,"threshold_uncertainty_score":0.005441666,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2010713047","doi":"10.1016/j.bmcl.2007.10.033","title":"Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Phenanthrene; IC50; Oral administration; Analgesic; Indole test; Orally active; Imidazole; Stereochemistry; Carboxylic acid; In vitro; Biochemistry; Organic chemistry","authors":[{"name":"Bernard Côté","is_ca":true},{"name":"Louise Boulet","is_ca":true},{"name":"Christine Brideau","is_ca":true},{"name":"David Claveau","is_ca":true},{"name":"Diane Ethier","is_ca":true},{"name":"Richard Frenette","is_ca":true},{"name":"Marc Gagnon","is_ca":true},{"name":"André Giroux","is_ca":true},{"name":"Jocelyne Guay","is_ca":true},{"name":"Sébastien Guiral","is_ca":true},{"name":"Joseph A. Mancini","is_ca":true},{"name":"Evelyn Martins","is_ca":true},{"name":"Frédéric Massé","is_ca":true},{"name":"Nathalie Méthot","is_ca":true},{"name":"Denis Riendeau","is_ca":true},{"name":"Joel Rubin","is_ca":true},{"name":"Daigen Xu","is_ca":true},{"name":"Hongping Yu","is_ca":true},{"name":"Yves Ducharme","is_ca":true},{"name":"Richard W. Friesen","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004358412619657795,"gpt":0.2204888019506904,"spread":0.2161303893310326,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810212,0.0003374794,0.0003759086,0.0001861182,0.0001244861,0.000206099,0.0003648626,0.0002366881,0.001286432],"category_scores_gemma":[0.0001170652,0.0001487325,0.0001141669,0.0001990425,0.0001679609,0.0002351535,0.0001818119,0.0005684819,0.0003122003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331374,"about_ca_system_score_gemma":0.0001556559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000262532,"about_ca_topic_score_gemma":0.0009834559,"domain_scores_codex":[0.9999324,0.00001282933,0.000004493608,0.000009714564,0.00001671523,0.00002382213],"domain_scores_gemma":[0.9999696,0.000005371619,0.000007938019,0.000003776938,0.000003207026,0.00001004345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001723377,0.0002287638,0.000240546,0.0002041024,0.00002405782,0.0003584203,0.00005584161,0.001558731,0.9607817,0.0009114527,0.0007755432,0.03313746],"study_design_scores_gemma":[0.000757153,0.005123897,0.00330226,0.00002386285,0.00008640974,0.00141075,0.00003603451,0.002522113,0.9690816,0.0002786129,0.01735036,0.00002693373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686162,0.01887997,0.004700151,0.0003584969,0.0001573596,0.0001025197,0.0004454363,0.0002714298,0.006468458],"genre_scores_gemma":[0.9835666,0.008933885,0.002106569,0.00009440517,0.00004017197,0.00004076558,0.000468828,0.00001899335,0.004729787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286432,"threshold_uncertainty_score":0.004303515,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2167614851","doi":"10.1523/jneurosci.4219-10.2011","title":"<i>Disc1</i>Point Mutations in Mice Affect Development of the Cerebral Cortex","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Department of Psychiatry, University of Toronto; University of Toronto; National Alliance for Research on Schizophrenia and Depression","keywords":"Affect (linguistics); Neuroscience; DISC1; Cerebral cortex; Point mutation; Psychology; Biology; Mutation; Genetics; Communication; Gene","authors":[{"name":"Frankie H. F. Lee","is_ca":true},{"name":"Marc P. Fadel","is_ca":true},{"name":"Kate Preston-Maher","is_ca":false},{"name":"Sabine P. Cordes","is_ca":true},{"name":"Steven J. Clapcote","is_ca":false},{"name":"David J. Price","is_ca":false},{"name":"John Roder","is_ca":true},{"name":"Albert H.C. Wong","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0229971816207023,"gpt":0.2486882493311554,"spread":0.2256910677104531,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003011809,0.001560596,0.0004586999,0.001484173,0.0005718883,0.0005666213,0.0005851684,0.001061496,0.006756375],"category_scores_gemma":[0.0002213668,0.0005372305,0.0004205448,0.0003835533,0.001160106,0.0002963315,0.0007108607,0.001151474,0.001893456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007481007,"about_ca_system_score_gemma":0.0004307601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002103918,"about_ca_topic_score_gemma":0.002747541,"domain_scores_codex":[0.9996316,0.00005036011,0.00005861725,0.0001014003,0.00009657616,0.00006146065],"domain_scores_gemma":[0.9994324,0.00006196958,0.0002881395,0.00002892062,0.00002330877,0.0001652123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004517389,0.00008888538,0.0004514919,0.00009801086,0.00002695407,0.0007012652,0.00005397967,0.0001725173,0.9943904,0.0005787074,0.0005584208,0.002427582],"study_design_scores_gemma":[0.0003334528,0.0005588438,0.01441058,0.00009178658,0.0001195183,0.005676371,0.0001389973,0.001878432,0.9640579,0.0005434437,0.01215533,0.00003543686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735097,0.0016667,0.007823641,0.0009882206,0.0002091112,0.0001835784,0.006312738,0.00128135,0.008025015],"genre_scores_gemma":[0.9680727,0.001453484,0.01146457,0.0003980928,0.00007613982,0.0001944859,0.002799092,0.0006096849,0.01493174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006756375,"threshold_uncertainty_score":0.02260232,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2151425122","doi":"10.1124/mol.104.004853","title":"Vascular Endothelial Cell Cyclic Nucleotide Phosphodiesterases and Regulated Cell Migration: Implications in Angiogenesis","year":2004,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Angiogenesis; Phosphodiesterase 3; Forskolin; Phosphodiesterase; Umbilical vein; Biology; Cell biology; Endothelial stem cell; Cell migration; Pharmacology; Cell; Biochemistry; Enzyme; Cancer research; Receptor","authors":[{"name":"Stuart J. Netherton","is_ca":true},{"name":"Donald H. Maurice","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005723289441968769,"gpt":0.2338554010782093,"spread":0.2281321116362405,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000356747,0.0005658506,0.0003995255,0.0005594285,0.0003477739,0.0007977312,0.0005920454,0.0009780541,0.001054633],"category_scores_gemma":[0.000297214,0.0002460836,0.0001944483,0.0003962906,0.0008027159,0.0008847277,0.0002236425,0.00104952,0.0002850887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007871643,"about_ca_system_score_gemma":0.0003814059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007526163,"about_ca_topic_score_gemma":0.0008367196,"domain_scores_codex":[0.999893,0.00003281936,0.000005690361,0.00001437422,0.00001693174,0.00003714476],"domain_scores_gemma":[0.9998555,0.00003573659,0.00002941198,0.0000124306,0.00001954625,0.00004734012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002196012,0.0003553226,0.001081328,0.0003289148,0.00002576874,0.001539308,0.0001324625,0.0009524716,0.9197744,0.03464673,0.001456648,0.03751076],"study_design_scores_gemma":[0.0004760699,0.002301401,0.04814972,0.0001725674,0.0001506876,0.006440547,0.0005639954,0.007758284,0.8619351,0.03214172,0.03980967,0.0001001939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6883873,0.2340408,0.03478529,0.01457692,0.001334813,0.000107725,0.0005321075,0.0002798588,0.02595512],"genre_scores_gemma":[0.9397196,0.04568405,0.006605692,0.0007653775,0.0004456223,0.00006867297,0.000177762,0.00001809639,0.006515175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054633,"threshold_uncertainty_score":0.005711317,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2046225958","doi":"10.1016/s1367-5931(00)00224-6","title":"The next generation of PDE4 inhibitors","year":2001,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Rheumatoid arthritis; Clinical trial; Medicine; Pulmonary disease; Disease; Asthma; Pharmacology; Immunology; Internal medicine","authors":[{"name":"Zheng Huang","is_ca":true},{"name":"Yves Ducharme","is_ca":true},{"name":"Dwight Macdonald","is_ca":true},{"name":"Annette Robichaud","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1736957818726307,"gpt":0.393814393047794,"spread":0.2201186111751633,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001162266,0.00136821,0.001804314,0.000897377,0.0003202164,0.001362664,0.001614783,0.001907488,0.00854989],"category_scores_gemma":[0.0006524159,0.0003553392,0.0008337155,0.0006462774,0.0007797906,0.00302502,0.0008119839,0.004874589,0.005174516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008724993,"about_ca_system_score_gemma":0.0007434723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006716388,"about_ca_topic_score_gemma":0.001634245,"domain_scores_codex":[0.9997815,0.00003504044,0.00001650638,0.00005305526,0.00007124933,0.00004265054],"domain_scores_gemma":[0.9997637,0.00009297427,0.00002460096,0.00001378293,0.00005364511,0.00005138739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004155215,0.0001926007,0.0001918632,0.003550717,0.00009271113,0.0003907825,0.00004966229,0.0006557397,0.01137088,0.01213851,0.09092814,0.8800229],"study_design_scores_gemma":[0.0001559074,0.0002782796,0.0003619693,0.0004693313,0.00007982673,0.0008091353,0.00003085529,0.0002592407,0.002061271,0.00458171,0.9908862,0.00002623874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009644788,0.9786919,0.004118391,0.006695678,0.002478374,0.00003535778,0.0001106514,0.0001247697,0.00678035],"genre_scores_gemma":[0.005390103,0.9630573,0.00542633,0.01136913,0.002162223,0.0001084541,0.0003946048,0.00003043276,0.01206132],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00854989,"threshold_uncertainty_score":0.02860224,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2068788937","doi":"10.1038/sj.bjp.0704457","title":"Assessing the emetic potential of PDE4 inhibitors in rats","year":2002,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Zaprinast; Pharmacology; Chemistry; Rolipram; Xylazine; Phosphodiesterase inhibitor; Aminophylline; Phosphodiesterase; Endocrinology; Ketamine; Medicine; Anesthesia; Biochemistry","authors":[{"name":"Annette Robichaud","is_ca":true},{"name":"Chantal Savoie","is_ca":true},{"name":"Panagiota B. Stamatiou","is_ca":true},{"name":"Nicholas Lachance","is_ca":true},{"name":"Paul Jolicoeur","is_ca":true},{"name":"Roberta Rasori","is_ca":true},{"name":"C C Chan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01310321596455183,"gpt":0.2849727749419598,"spread":0.271869558977408,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000517635,0.001252734,0.0007893649,0.0009766272,0.0002399597,0.0003440873,0.0004559151,0.0008160535,0.002177513],"category_scores_gemma":[0.0005081326,0.0004103051,0.0006355243,0.000362138,0.0007273198,0.0007773567,0.0003528725,0.001881135,0.0005549869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005293826,"about_ca_system_score_gemma":0.0004710084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007881994,"about_ca_topic_score_gemma":0.001414939,"domain_scores_codex":[0.9995989,0.00005903299,0.00002843172,0.00008441035,0.00007602545,0.0001531924],"domain_scores_gemma":[0.9992995,0.00008957968,0.0002326347,0.0000667073,0.00009173803,0.0002198292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005961775,0.001165442,0.0007094562,0.0001236879,0.00004619058,0.0001791779,0.00007700387,0.0002351039,0.98492,0.0001572063,0.0001593465,0.006265638],"study_design_scores_gemma":[0.0003326979,0.04090552,0.009597732,0.00001861265,0.000183402,0.0003319427,0.0001604172,0.001080304,0.9450755,0.0001377314,0.002149693,0.00002649449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908,0.003225995,0.002785556,0.0002312512,0.0001084559,0.0001759577,0.0007325705,0.0001823318,0.001758004],"genre_scores_gemma":[0.9746652,0.007523813,0.005271072,0.0003402848,0.0001791931,0.0005141178,0.001437724,0.00005937496,0.01000929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177513,"threshold_uncertainty_score":0.007284462,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1989014719","doi":"10.1016/j.febslet.2012.07.058","title":"Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center","year":2012,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Bimetal; Phosphodiesterase; In vitro; Enzyme; Boron; Catechol; Biochemistry; Stereochemistry; Combinatorial chemistry; Organic chemistry","authors":[{"name":"Yvonne R. Freund","is_ca":false},{"name":"Tsutomu Akama","is_ca":false},{"name":"M.R. Alley","is_ca":false},{"name":"Joana Antunes","is_ca":false},{"name":"Chen Dong","is_ca":false},{"name":"Kurt Jarnagin","is_ca":false},{"name":"Richard H. Kimura","is_ca":false},{"name":"James A. Nieman","is_ca":true},{"name":"Kirk R. Maples","is_ca":false},{"name":"Jacob J. Plattner","is_ca":false},{"name":"Fernando Rock","is_ca":false},{"name":"Rashmi Sharma","is_ca":true},{"name":"Rajeshwar Singh","is_ca":true},{"name":"Virginia Sanders","is_ca":false},{"name":"Yasheen Zhou","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01248766838825154,"gpt":0.2375271607134349,"spread":0.2250394923251834,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283402,0.0003486388,0.0002826467,0.0001307029,0.0001549528,0.0003773531,0.0005038019,0.000357265,0.001891941],"category_scores_gemma":[0.0001563122,0.0001982143,0.0001995382,0.0001036685,0.0002782325,0.0003072128,0.0002858946,0.0005211344,0.0003427285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004671612,"about_ca_system_score_gemma":0.0001823284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008472452,"about_ca_topic_score_gemma":0.0009716279,"domain_scores_codex":[0.9998572,0.00002236244,0.000007817039,0.0000274548,0.00003331574,0.00005177868],"domain_scores_gemma":[0.9999598,0.000009027607,0.00001218582,0.000004594198,0.00000416211,0.000010246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000233655,0.00007175469,0.0001342805,0.00009843225,0.00001493118,0.00009086668,0.00002501542,0.0007051791,0.9917241,0.001757099,0.0002096886,0.004935184],"study_design_scores_gemma":[0.00005204914,0.0002563493,0.0001587389,0.000002513175,0.00001124294,0.00007530053,0.000006496362,0.0008248509,0.9956294,0.0000965517,0.002878731,0.00000761083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731022,0.003004034,0.01385261,0.0005346203,0.00007197224,0.00006649587,0.0002371222,0.0002527185,0.008878305],"genre_scores_gemma":[0.9867377,0.0009693688,0.008331254,0.0001612733,0.00001387854,0.00002676199,0.000164282,0.00003175281,0.003563839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001891941,"threshold_uncertainty_score":0.006329179,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4295452439","doi":"10.1038/s41467-022-32994-7","title":"A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Basic and Applied Basic Research Foundation of Guangdong Province; Peking University; National Key Research and Development Program of China; Campbell Family Mental Health Research Institute; National Natural Science Foundation of China","keywords":"Fluorescence; Aequorea victoria; Second messenger system; Green fluorescent protein; Intracellular; Endogeny; Cell biology; HEK 293 cells; Yellow fluorescent protein; In vivo; Biophysics; Biology; Chemistry; Receptor; Biochemistry; Genetics; Gene","authors":[{"name":"Liang Wang","is_ca":false},{"name":"Chunling Wu","is_ca":false},{"name":"Wanling Peng","is_ca":false},{"name":"Ziliang Zhou","is_ca":false},{"name":"Jianzhi Zeng","is_ca":false},{"name":"Xuelin Li","is_ca":false},{"name":"Yini Yang","is_ca":false},{"name":"Shuguang Yu","is_ca":false},{"name":"Ye Zou","is_ca":false},{"name":"Mian Huang","is_ca":false},{"name":"Chang Liu","is_ca":false},{"name":"Yefei Chen","is_ca":false},{"name":"Yi Li","is_ca":false},{"name":"Panpan Ti","is_ca":false},{"name":"Wenfeng Liu","is_ca":false},{"name":"Yufeng Gao","is_ca":false},{"name":"Wei Zheng","is_ca":false},{"name":"Haining Zhong","is_ca":false},{"name":"Shangbang Gao","is_ca":false},{"name":"Zhonghua Lu","is_ca":false},{"name":"Pei‐Gen Ren","is_ca":false},{"name":"Ho Leung Ng","is_ca":false},{"name":"Jie He","is_ca":false},{"name":"Shoudeng Chen","is_ca":false},{"name":"Min Xu","is_ca":false},{"name":"Yulong Li","is_ca":false},{"name":"Jun Chu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00734476450003837,"gpt":0.2558236783598519,"spread":0.2484789138598135,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002308917,0.0002436611,0.0001916859,0.0001370093,0.0001054045,0.0002594859,0.0004188015,0.0005547334,0.0007340211],"category_scores_gemma":[0.0001781445,0.000143703,0.0001297178,0.0001365927,0.0002135191,0.0002344119,0.0002370263,0.0007534645,0.0004683593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331657,"about_ca_system_score_gemma":0.0001779486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004282258,"about_ca_topic_score_gemma":0.0005257201,"domain_scores_codex":[0.9998878,0.00002324235,0.000005024115,0.00002823041,0.00003651517,0.00001923921],"domain_scores_gemma":[0.999904,0.0000212145,0.00002175903,0.00001063604,0.00001437937,0.00002792225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007936199,0.000004027101,0.0000204945,0.000007857522,6.301963e-7,0.00001199896,0.000002382709,0.00003689783,0.9993162,0.00006052171,0.000032147,0.00049887],"study_design_scores_gemma":[0.000005931475,0.00004865249,0.0003032302,0.000001892881,0.000003264152,0.0001161244,0.000003645594,0.002013364,0.9958408,0.00003202097,0.001627383,0.000003576815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8326702,0.001444071,0.1609917,0.0006220699,0.0001175956,0.0001343112,0.0007176589,0.0007906609,0.002511722],"genre_scores_gemma":[0.8545004,0.0008324087,0.1391795,0.0001661266,0.00002525782,0.0001374623,0.0008542202,0.0001054256,0.004199222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007340211,"threshold_uncertainty_score":0.002455592,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2116714338","doi":"10.1161/circresaha.111.250464","title":"Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca <sup>2+</sup> Release and Cardiac Contractility, Independently of L-Type Ca <sup>2+</sup> Current","year":2011,"lang":"en","type":"article","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary; Queen's University; University Health Network","funders":"National Institutes of Health; University of Toronto; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Endoplasmic reticulum; Contractility; Calcium; Internal medicine; Chemistry; Phosphodiesterase; Biophysics; Endocrinology; Medicine; Biology; Enzyme; Biochemistry","authors":[{"name":"Sanja Beca","is_ca":true},{"name":"Peter B. Helli","is_ca":true},{"name":"Jeremy A. Simpson","is_ca":true},{"name":"Dongling Zhao","is_ca":true},{"name":"Gerrie P. Farman","is_ca":true},{"name":"Peter P. Jones","is_ca":true},{"name":"Xixi Tian","is_ca":true},{"name":"Lindsay S. Wilson","is_ca":true},{"name":"Faiyaz Ahmad","is_ca":true},{"name":"S.R. Wayne Chen","is_ca":true},{"name":"Matthew A. Movsesian","is_ca":true},{"name":"Vincent Manganiello","is_ca":true},{"name":"Donald H. Maurice","is_ca":true},{"name":"Marco Conti","is_ca":true},{"name":"Peter H. Backx","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0427226054990063,"gpt":0.30889280429658,"spread":0.2661701987975737,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003160784,0.0005712272,0.0002978647,0.000265118,0.0002221108,0.0004021012,0.0004243258,0.000439365,0.001727563],"category_scores_gemma":[0.0002137552,0.0002926909,0.0003301546,0.000103891,0.0006852699,0.000338706,0.0003630458,0.0006190888,0.0004543579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005062509,"about_ca_system_score_gemma":0.0002818679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003134992,"about_ca_topic_score_gemma":0.000638728,"domain_scores_codex":[0.9998322,0.00002725371,0.00002472356,0.00005372742,0.00002827329,0.0000339035],"domain_scores_gemma":[0.999689,0.00003463594,0.0001482579,0.000032138,0.00001899293,0.0000770649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005125767,0.00004710356,0.001315614,0.00005302409,0.000006041054,0.00007181476,0.00001243733,0.00003195568,0.996789,0.00007760675,0.00004436645,0.001038444],"study_design_scores_gemma":[0.0001898116,0.001270833,0.03726672,0.00003070461,0.00006892414,0.0006836342,0.00008932266,0.0007417524,0.9566599,0.0001091861,0.002876041,0.00001325045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927902,0.002097338,0.002896892,0.000287718,0.00003526693,0.0000689239,0.000822878,0.00009903465,0.0009016708],"genre_scores_gemma":[0.9912357,0.001460216,0.003379283,0.0001420109,0.00002326133,0.0001655626,0.0008120441,0.00003921525,0.002742733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727563,"threshold_uncertainty_score":0.005779207,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1752163017","doi":"10.1113/jphysiol.2007.140210","title":"Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness","year":2007,"lang":"en","type":"review","venue":"The Journal of Physiology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"DISC1; Mental illness; Schizophrenia (object-oriented programming); Psychiatry; Psychology; Neuroscience; Medicine; Biology; Gene; Genetics; Mental health","authors":[{"name":"J. Kirsty Millar","is_ca":false},{"name":"Shaun Mackie","is_ca":false},{"name":"Steven J. Clapcote","is_ca":true},{"name":"Hannah Murdoch","is_ca":false},{"name":"Ben Pickard","is_ca":false},{"name":"Sheila Christie","is_ca":false},{"name":"Walter Muir","is_ca":false},{"name":"Douglas Blackwood","is_ca":false},{"name":"John Roder","is_ca":true},{"name":"Miles D. Houslay","is_ca":false},{"name":"David J. Porteous","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04692353860690377,"gpt":0.335639940296977,"spread":0.2887164016900732,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006807814,0.001201384,0.001567646,0.002060418,0.000314444,0.0008830993,0.001075181,0.00185925,0.002874843],"category_scores_gemma":[0.0007707771,0.0003336638,0.0003484694,0.002109306,0.0008586813,0.001844724,0.0007978262,0.002594603,0.003030546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001062473,"about_ca_system_score_gemma":0.001040623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001434668,"about_ca_topic_score_gemma":0.00268287,"domain_scores_codex":[0.9998349,0.00003016109,0.00002787855,0.00002839126,0.00006515132,0.00001339524],"domain_scores_gemma":[0.999665,0.0001185976,0.0000472083,0.00001266537,0.00009490993,0.00006164139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001235419,0.00006828013,0.0003090811,0.007547298,0.00007169091,0.0005466277,0.00007538959,0.0004795561,0.002159521,0.005897651,0.07837807,0.9043433],"study_design_scores_gemma":[0.00002310916,0.0000537524,0.001040356,0.001554263,0.00004614541,0.002473571,0.00005689363,0.00009431906,0.000252652,0.002790103,0.9916005,0.00001439106],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008717048,0.9977224,0.0002263229,0.0006273157,0.0003876899,0.000002977657,0.00001045264,0.000008811297,0.0009268195],"genre_scores_gemma":[0.0005137275,0.9972669,0.0003974762,0.0003422615,0.0003800159,0.000006181805,0.00002585755,0.000002349371,0.00106526],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002874843,"threshold_uncertainty_score":0.009617329,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1995559527","doi":"10.1161/circresaha.107.156422","title":"PI3Kγ Is Required for PDE4, not PDE3, Activity in Subcellular Microdomains Containing the Sarcoplasmic Reticular Calcium ATPase in Cardiomyocytes","year":2007,"lang":"en","type":"article","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University; University of Calgary","funders":"","keywords":"Sarcoplasm; Calcium; Cell biology; Reticular connective tissue; ATPase; Chemistry; Calcium ATPase; Subcellular localization; Endoplasmic reticulum; Biophysics; Biology; Biochemistry; Enzyme; Anatomy; Cytoplasm","authors":[{"name":"Benoît‐Gilles Kerfant","is_ca":true},{"name":"Dongling Zhao","is_ca":true},{"name":"Ilka Lorenzen‐Schmidt","is_ca":true},{"name":"Lindsay S. Wilson","is_ca":true},{"name":"Shitian Cai","is_ca":true},{"name":"S. R. Wayne Chen","is_ca":true},{"name":"Donald H. Maurice","is_ca":true},{"name":"Peter H. Backx","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08676807596898532,"gpt":0.3737099767794062,"spread":0.2869419008104208,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181965,0.0006468481,0.0003698171,0.0002969661,0.0003867124,0.0005902779,0.0004853811,0.0004572301,0.001646179],"category_scores_gemma":[0.0002935645,0.0003874093,0.0006934904,0.0001772053,0.0005273359,0.0003345658,0.0005472182,0.0008626308,0.001030084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005734477,"about_ca_system_score_gemma":0.0004673694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001647915,"about_ca_topic_score_gemma":0.001526763,"domain_scores_codex":[0.9998425,0.0000165105,0.00002347309,0.00004032507,0.00003048056,0.00004658647],"domain_scores_gemma":[0.9997396,0.00002841564,0.0001100604,0.00003815644,0.00002440057,0.00005935412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001845351,0.000009932925,0.0002824948,0.00002951309,0.000009319355,0.0001541488,0.00001861135,0.00004116604,0.9987475,0.0001226146,0.00003110634,0.0003691716],"study_design_scores_gemma":[0.0001186446,0.00009263193,0.02485778,0.00002479527,0.00007762513,0.0008889824,0.0001111741,0.001430366,0.9685338,0.000255289,0.003592473,0.00001636576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910049,0.002228155,0.003945134,0.0003489128,0.00007776127,0.00003267663,0.0007293457,0.0001391097,0.001494088],"genre_scores_gemma":[0.9932035,0.001202827,0.001770113,0.0001423103,0.00002072715,0.00005688754,0.0008419788,0.00006716941,0.002694388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647915,"threshold_uncertainty_score":0.005507052,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3043541583","doi":"10.1016/j.phrs.2020.105078","title":"Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders","year":2020,"lang":"en","type":"review","venue":"Pharmacological Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"National Health and Medical Research Council; Australian Research Council; Sultan Qaboos University; Indian Council of Medical Research; Macquarie University","keywords":"Apremilast; Medicine; Roflumilast; Adverse effect; Atopic dermatitis; Phosphodiesterase; Pharmacology; Disease; Internal medicine; COPD; Immunology; Psoriatic arthritis; Enzyme","authors":[{"name":"Abid Bhat","is_ca":false},{"name":"Bipul Ray","is_ca":false},{"name":"Arehally M. Mahalakshmi","is_ca":false},{"name":"Sunanda Tuladhar","is_ca":false},{"name":"DN Nandakumar","is_ca":false},{"name":"Malathi Srinivasan","is_ca":false},{"name":"Musthafa Mohamed Essa","is_ca":false},{"name":"Saravana Babu Chidambaram","is_ca":false},{"name":"Gilles J. Guillemin","is_ca":false},{"name":"Meena Kishore Sakharkar","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1374044233877811,"gpt":0.4636342922313814,"spread":0.3262298688436004,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005827614,0.001187895,0.001549201,0.001686956,0.0002248554,0.0009415348,0.0008231935,0.00106761,0.004145803],"category_scores_gemma":[0.0005454707,0.0002612969,0.000409463,0.001757365,0.0004791442,0.001016309,0.0007351306,0.002297256,0.002133338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005351094,"about_ca_system_score_gemma":0.0008116911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008106368,"about_ca_topic_score_gemma":0.002192629,"domain_scores_codex":[0.9998859,0.00001844459,0.00001387181,0.00002075653,0.00004305519,0.00001805971],"domain_scores_gemma":[0.9998531,0.00006716402,0.00001997647,0.000005169496,0.00003468341,0.00001983281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002106595,0.0001112043,0.00008445991,0.01138039,0.0001038667,0.0002515433,0.00003102641,0.0004336152,0.003522931,0.004160753,0.03795628,0.9417533],"study_design_scores_gemma":[0.00007996988,0.0001464497,0.0004903509,0.002302449,0.0002070916,0.001021298,0.00004082685,0.000170735,0.0008178589,0.002869839,0.9918323,0.00002087904],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001040693,0.998333,0.0001974267,0.0002128138,0.0002702585,0.000005060161,0.00002041778,0.000009406061,0.0008475391],"genre_scores_gemma":[0.0007011154,0.9977499,0.0003210392,0.000200479,0.0002156774,0.000008864142,0.00003881313,0.000002304479,0.0007617318],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004145803,"threshold_uncertainty_score":0.01386911,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1970285386","doi":"10.1016/j.neuron.2014.11.007","title":"A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects","year":2014,"lang":"en","type":"article","venue":"Neuron","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Systems, Applications & Products in Data Processing (Canada); Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Western University; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Johns Hopkins University","keywords":"Dopamine receptor D2; DISC1; Antipsychotic; Neuroscience; Dopamine receptor; Dopamine; Schizophrenia (object-oriented programming); Receptor; Psychology; Chemistry; Biology; Psychiatry; Genetics; Gene","authors":[{"name":"Ping Su","is_ca":true},{"name":"Shupeng Li","is_ca":true},{"name":"Sheng Chen","is_ca":true},{"name":"Tatiana V. Lipina","is_ca":true},{"name":"Min Wang","is_ca":true},{"name":"Terence K.Y. Lai","is_ca":true},{"name":"Frankie H. F. Lee","is_ca":true},{"name":"Hailong Zhang","is_ca":true},{"name":"Dongxu Zhai","is_ca":true},{"name":"Stephen S. G. Ferguson","is_ca":true},{"name":"José N. Nóbrega","is_ca":true},{"name":"Albert H.C. Wong","is_ca":true},{"name":"John Roder","is_ca":true},{"name":"Paul Fletcher","is_ca":true},{"name":"Fang Liu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008861688087448463,"gpt":0.2418114517198029,"spread":0.2329497636323544,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879558,0.0005689749,0.0002907856,0.0003127542,0.0004254628,0.0006358539,0.0003542546,0.0005012321,0.001929798],"category_scores_gemma":[0.0002173585,0.0002187208,0.0003031523,0.0001177248,0.0002947994,0.0002792415,0.0003158751,0.0004788664,0.0003634846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001297305,"about_ca_system_score_gemma":0.0002946008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001219236,"about_ca_topic_score_gemma":0.001814827,"domain_scores_codex":[0.9998986,0.00001877367,0.000009249836,0.00002142876,0.00002547972,0.00002646424],"domain_scores_gemma":[0.9998645,0.00001329479,0.0000560603,0.0000125997,0.00001452819,0.00003908749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007747324,0.00005780423,0.002295612,0.0001134004,0.00005334584,0.0009110037,0.00003484325,0.0002995627,0.9909953,0.001785815,0.0003672159,0.002311273],"study_design_scores_gemma":[0.0001847289,0.000443792,0.07599548,0.00003395616,0.0001430083,0.004853985,0.0001935281,0.006252042,0.8979542,0.001833526,0.0120738,0.00003802376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849562,0.0046788,0.003672329,0.001078848,0.000119687,0.00005311828,0.0006746338,0.0001187628,0.004647705],"genre_scores_gemma":[0.9947008,0.0008682782,0.001242627,0.000125306,0.00001563337,0.00001242634,0.0004216714,0.00001554744,0.0025977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001929798,"threshold_uncertainty_score":0.009412706,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1955942895","doi":"10.1124/jpet.103.064691","title":"Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Rolipram; Cytokine; Tumor necrosis factor alpha; Peripheral blood mononuclear cell; Ovalbumin; T cell; Chemistry; Molecular biology; Biology; In vitro; Phosphodiesterase; Immunology; Immune system; Biochemistry; Enzyme","authors":[{"name":"David Claveau","is_ca":true},{"name":"S L Chen","is_ca":false},{"name":"Stephen J. O’Keefe","is_ca":false},{"name":"Dennis M. Zaller","is_ca":false},{"name":"Angela Styhler","is_ca":false},{"name":"S. Liu","is_ca":false},{"name":"Zheng Huang","is_ca":false},{"name":"Donald W. Nicholson","is_ca":false},{"name":"Joseph A. Mancini","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01219050924459143,"gpt":0.2809521604573458,"spread":0.2687616512127544,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002994787,0.0005666302,0.0004376174,0.0002076105,0.0001254151,0.0003127932,0.000258912,0.0002846395,0.001873429],"category_scores_gemma":[0.0001805299,0.0002242974,0.0002367095,0.0001594533,0.000197944,0.0001804602,0.000139685,0.0008546928,0.0007325201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001979196,"about_ca_system_score_gemma":0.0003471027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003483715,"about_ca_topic_score_gemma":0.0008074878,"domain_scores_codex":[0.999739,0.00005136065,0.00002200361,0.00003108515,0.00003484926,0.0001217496],"domain_scores_gemma":[0.9998361,0.00005858023,0.00002677526,0.00001950425,0.00001168574,0.00004729557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008974507,0.0001125648,0.0001187363,0.00005480547,0.000004504566,0.00006843527,0.0000113731,0.00008213258,0.9970939,0.00006602962,0.00009459904,0.001395494],"study_design_scores_gemma":[0.0001565883,0.001530271,0.001757679,0.000005906662,0.00001719822,0.0002044446,0.00001341638,0.0004499277,0.9946871,0.00002500243,0.0011488,0.000003628188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874738,0.005050571,0.001844866,0.0001577593,0.0001603854,0.00006327285,0.0005615067,0.0001382116,0.004549747],"genre_scores_gemma":[0.9927561,0.00195996,0.001366248,0.00009184153,0.00009533911,0.0000560799,0.0007089705,0.00002396318,0.002941454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873429,"threshold_uncertainty_score":0.00626725,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2789822035","doi":"10.1016/j.niox.2018.03.008","title":"Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets","year":2018,"lang":"en","type":"review","venue":"Nitric Oxide","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Jewish General Hospital","funders":"Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; Bundesministerium für Bildung und Forschung; Russian Foundation for Basic Research; Irish Research Council; Deutsche Forschungsgemeinschaft","keywords":"Prostacyclin; Riociguat; Platelet; cGMP-dependent protein kinase; Cell biology; Protein kinase A; Phosphorylation; Chemistry; Platelet activation; Iloprost; Kinase; Soluble guanylyl cyclase; PDE10A; Phosphodiesterase; Biology; Biochemistry; Receptor; Guanylate cyclase; Mitogen-activated protein kinase kinase; Immunology; Enzyme","authors":[{"name":"Stephanie Makhoul","is_ca":false},{"name":"Elena Walter","is_ca":false},{"name":"Oliver Pagel","is_ca":false},{"name":"Ulrich Walter","is_ca":false},{"name":"Albert Sickmann","is_ca":false},{"name":"Stepan Gambaryan","is_ca":false},{"name":"Albert Smolenski","is_ca":false},{"name":"René P. Zahedi","is_ca":true},{"name":"Kerstin Jurk","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01602021784962643,"gpt":0.2575598651995147,"spread":0.2415396473498883,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000553939,0.0006308871,0.0008963943,0.001011931,0.0002117476,0.000719891,0.0006886612,0.0007871306,0.001170935],"category_scores_gemma":[0.0006312188,0.0002268419,0.0002511463,0.001129283,0.0005101774,0.0008144625,0.000600452,0.001362281,0.0005988468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004239494,"about_ca_system_score_gemma":0.001031437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008834448,"about_ca_topic_score_gemma":0.001415153,"domain_scores_codex":[0.9998653,0.00001876614,0.00002313491,0.00003054113,0.0000486454,0.00001358627],"domain_scores_gemma":[0.9997696,0.0001064729,0.00004136713,0.000007013702,0.00005203154,0.00002350236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001489976,0.00004986017,0.0002934038,0.01591738,0.00007740596,0.0003768188,0.0000593637,0.0003746981,0.005113778,0.005236965,0.01785599,0.9544953],"study_design_scores_gemma":[0.00003935357,0.0001558737,0.001954506,0.002972231,0.000206852,0.001977181,0.00008500995,0.0001785444,0.002449627,0.004613392,0.9853357,0.00003163144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001373721,0.9990595,0.00007556817,0.0001898289,0.0001546065,0.000001864887,0.00001060294,0.000002121758,0.0003685274],"genre_scores_gemma":[0.0008135028,0.9985195,0.00008960765,0.0001136064,0.0002043747,0.000002584171,0.00001611382,5.319887e-7,0.0002401877],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001170935,"threshold_uncertainty_score":0.003917158,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2042242996","doi":"10.1016/j.coph.2005.04.001","title":"Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors","year":2005,"lang":"en","type":"review","venue":"Current Opinion in Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Phosphodiesterase; Roflumilast; Medicine; Phosphodiesterase 3; Adverse effect; Asthma; Pulmonary disease; Clinical trial; Pharmacology; Limiting; Intensive care medicine; Bioinformatics; Internal medicine; Enzyme; Chemistry; Biology; Biochemistry","authors":[{"name":"Mark A. Giembycz","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04772506309881403,"gpt":0.3705159320219377,"spread":0.3227908689231237,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008563367,0.001247864,0.002270265,0.0006778305,0.0002759784,0.0007906767,0.001313997,0.00154097,0.00403867],"category_scores_gemma":[0.0005556613,0.0002001468,0.0005839719,0.000630129,0.0005197748,0.001138609,0.0004301032,0.002641389,0.002662734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004935029,"about_ca_system_score_gemma":0.0004448237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004702317,"about_ca_topic_score_gemma":0.00136953,"domain_scores_codex":[0.9998332,0.00002857527,0.00001807056,0.00003239667,0.0000594073,0.00002828287],"domain_scores_gemma":[0.9998174,0.00008775037,0.00002770668,0.000007014051,0.00003335801,0.00002682091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004301175,0.0001528876,0.0001428551,0.004899611,0.0001130434,0.0004794152,0.00003128313,0.0004019219,0.004934407,0.002910336,0.04252289,0.9429813],"study_design_scores_gemma":[0.000320051,0.0006247457,0.001209729,0.0009522457,0.0002175939,0.002779778,0.00004639439,0.0002624196,0.00293509,0.002408338,0.9882088,0.00003480566],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008560098,0.9924365,0.001134414,0.001398184,0.00127048,0.00001641321,0.00003921949,0.00004874762,0.002800073],"genre_scores_gemma":[0.004819995,0.9859453,0.0011864,0.001782474,0.001233467,0.00003299748,0.000116236,0.00001095761,0.004872126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00403867,"threshold_uncertainty_score":0.01351064,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2500951909","doi":"10.1136/heartjnl-2015-309223","title":"Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality","year":2016,"lang":"en","type":"article","venue":"Heart","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Health Sciences Centre","funders":"NIHR Oxford Biomedical Research Centre; Medical Research Council; National Institute for Health and Care Research; British Heart Foundation; Amgen","keywords":"Medicine; Internal medicine; Type 2 diabetes; Aspirin; Myocardial infarction; Retrospective cohort study; Diabetes mellitus; Mortality rate; Cardiology; Endocrinology","authors":[{"name":"Simon Anderson","is_ca":false},{"name":"David Hutchings","is_ca":false},{"name":"Mark Woodward","is_ca":false},{"name":"Kazem Rahimi","is_ca":false},{"name":"Martin K. Rutter","is_ca":false},{"name":"Mike Kirby","is_ca":false},{"name":"Geoff Hackett","is_ca":false},{"name":"Andrew W. Trafford","is_ca":false},{"name":"Adrian Heald","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03732279141771348,"gpt":0.278270393144303,"spread":0.2409476017265895,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001171482,0.000241383,0.0003497381,0.0003784059,0.0002037059,0.0006099197,0.0004006615,0.000488724,0.004656405],"category_scores_gemma":[0.004855569,0.0002340367,0.0009456781,0.0009070535,0.0001789428,0.0003207542,0.0004141738,0.0006881479,0.0004571666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275262,"about_ca_system_score_gemma":0.0002702374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004874494,"about_ca_topic_score_gemma":0.004479736,"domain_scores_codex":[0.9994288,0.0001411072,0.00008176274,0.0001584413,0.0001150797,0.00007479837],"domain_scores_gemma":[0.9973046,0.0004746959,0.001618801,0.0002534533,0.0001578727,0.0001905931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000583247,0.00004576365,0.9954947,0.00005721907,0.0002163335,0.0000518221,0.00001904045,0.00005428052,0.0002247787,0.00001568105,0.0002340199,0.003003155],"study_design_scores_gemma":[0.00001959299,0.00009229322,0.9993317,0.00001555291,0.0001112808,0.00009690232,0.00001680358,0.00008160631,0.00004569465,0.00001326452,0.0001733078,0.000001994326],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901727,0.003219725,0.0002582363,0.0002854452,0.00006593858,0.00001763342,0.004573412,0.00002158465,0.001385119],"genre_scores_gemma":[0.9965636,0.0009684846,0.00023991,0.00007730801,0.00007220476,0.00001121894,0.001537871,0.000004169184,0.0005250905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004874494,"threshold_uncertainty_score":0.0155772,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2131055445","doi":"10.1186/1465-9921-12-140","title":"Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects","year":2011,"lang":"en","type":"article","venue":"Respiratory Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; McMaster University","funders":"","keywords":"Roflumilast; Medicine; Bronchoconstriction; Allergen; Immunology; Eosinophil cationic protein; Eosinophil; Methacholine; Neutrophil elastase; Sputum; Asthma; Pharmacology; Inflammation; Allergy; Internal medicine; Lung; Respiratory disease; Pathology; COPD","authors":[{"name":"Gail M. Gauvreau","is_ca":true},{"name":"Louis‐Philippe Boulet","is_ca":true},{"name":"Christine Schmid-Wirlitsch","is_ca":false},{"name":"Johanne Côté","is_ca":true},{"name":"MyLinh Duong","is_ca":true},{"name":"Kieran J. Killian","is_ca":true},{"name":"Joanne Milot","is_ca":true},{"name":"Francine Deschesnes","is_ca":true},{"name":"Tara X. Strinich","is_ca":true},{"name":"Richard M. Watson","is_ca":true},{"name":"Dirk Bredenbröker","is_ca":false},{"name":"Paul M. O’Byrne","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1756188158713546,"gpt":0.3545227539186947,"spread":0.1789039380473401,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003459316,0.0003541013,0.001350431,0.0001423455,0.0002052222,0.0002109257,0.0002136006,0.0004125501,0.001697032],"category_scores_gemma":[0.0005583474,0.0001693037,0.0003127854,0.0001092574,0.0002549281,0.0001765201,0.0001274271,0.0006485321,0.000208997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944299,"about_ca_system_score_gemma":0.0002238797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004581111,"about_ca_topic_score_gemma":0.0009908873,"domain_scores_codex":[0.9998478,0.00005815902,0.00001266929,0.0000208556,0.00002823881,0.0000322968],"domain_scores_gemma":[0.9997124,0.00009409177,0.00006949454,0.00001154156,0.00001955835,0.00009296826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2686649,0.01872481,0.04760136,0.001820239,0.0007838511,0.000826448,0.0004123066,0.000617107,0.4808432,0.00007795503,0.001400201,0.1782276],"study_design_scores_gemma":[0.03684019,0.4205031,0.5132072,0.00008671101,0.0008674124,0.001003838,0.0001634662,0.0008919938,0.02266851,0.00009523433,0.003639654,0.00003266504],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964176,0.00279383,0.0001169473,0.0001012035,0.00003594565,0.0001094951,0.00006965813,0.00002352107,0.0003317583],"genre_scores_gemma":[0.9980945,0.0008367376,0.0002315982,0.0001385381,0.00007449753,0.00005689552,0.0001216693,0.000002523278,0.0004431247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001697032,"threshold_uncertainty_score":0.005677164,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2014705718","doi":"10.1074/jbc.m110.140004","title":"Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Phosphodiesterase; Cell biology; VE-cadherin; Intracellular; Cadherin; Vascular permeability; Signal transduction; Biology; Endothelial stem cell; Protein kinase A; Biochemistry; Cell; Chemistry; Phosphorylation; Enzyme; Endocrinology; In vitro","authors":[{"name":"Sarah Rampersad","is_ca":true},{"name":"Jeffrey D. Ovens","is_ca":true},{"name":"Elaine Huston","is_ca":false},{"name":"M. Bibiana Umana","is_ca":true},{"name":"Lindsay S. Wilson","is_ca":true},{"name":"Stuart J. Netherton","is_ca":true},{"name":"Martin J. Lynch","is_ca":false},{"name":"George S. Baillie","is_ca":false},{"name":"Miles D. Houslay","is_ca":false},{"name":"Donald H. Maurice","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0176219311874842,"gpt":0.2480888890944963,"spread":0.2304669579070121,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237692,0.0002163973,0.0002623061,0.0002809523,0.0002564464,0.0002890131,0.0001950704,0.0002653578,0.00130139],"category_scores_gemma":[0.0001403884,0.0002084706,0.0002979218,0.0001619264,0.0003077518,0.0001857574,0.0003977415,0.000459519,0.0005507636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006298108,"about_ca_system_score_gemma":0.0002384005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009360651,"about_ca_topic_score_gemma":0.001099788,"domain_scores_codex":[0.9998351,0.00002850282,0.00001672338,0.00004445224,0.00004248564,0.00003277462],"domain_scores_gemma":[0.9999418,0.00001136881,0.00001538838,0.00001086542,0.000007727852,0.00001277138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003721959,0.000007300036,0.0001769283,0.00001558868,0.000002939737,0.00002497211,0.000005456686,0.00008803756,0.9987941,0.00009896433,0.00002027519,0.0007280865],"study_design_scores_gemma":[0.000009320259,0.00007538924,0.003214867,0.000002904551,0.000009745375,0.0001618812,0.00002127863,0.001448741,0.9921116,0.00006356098,0.00287664,0.00000417969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897461,0.001322819,0.006736321,0.0001694059,0.00003386383,0.00002199686,0.0002809062,0.00006168395,0.001626796],"genre_scores_gemma":[0.9874337,0.0007160132,0.007310156,0.00008860587,0.000008285872,0.00003038597,0.0004591099,0.00001621661,0.003937536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130139,"threshold_uncertainty_score":0.00456965,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2156992491","doi":"10.1095/biolreprod66.1.180","title":"Effect of Type 3 and Type 4 Phosphodiesterase Inhibitors on the Maintenance of Bovine Oocytes in Meiotic Arrest1","year":2002,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Rolipram; Oocyte; Theca; Biology; Phosphodiesterase; Milrinone; Internal medicine; Andrology; Endocrinology; Cell biology; Ovary; Embryo; Biochemistry; Enzyme; Medicine","authors":[{"name":"Mario A. Mayes","is_ca":true},{"name":"Marc‐André Sirard","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01035026011924534,"gpt":0.2365255893495062,"spread":0.2261753292302609,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035479,0.0002860705,0.0005573677,0.0002080876,0.0001854252,0.0003691414,0.0003168904,0.0002125999,0.001062821],"category_scores_gemma":[0.0004075406,0.0001295781,0.0002873542,0.0001572373,0.0001475043,0.0001900109,0.0001606936,0.0003578042,0.0002153341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440419,"about_ca_system_score_gemma":0.0003031153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002138649,"about_ca_topic_score_gemma":0.00446848,"domain_scores_codex":[0.9997689,0.00006381444,0.00002925318,0.00003624626,0.00003809666,0.00006371119],"domain_scores_gemma":[0.999752,0.00008452155,0.00006638641,0.00002092522,0.00002992969,0.00004621855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002820198,0.0001712104,0.0006203623,0.0001813379,0.00002912758,0.00008158055,0.00006446369,0.00009231848,0.9895077,0.00005502094,0.0001733688,0.006203393],"study_design_scores_gemma":[0.0001751953,0.004970042,0.01576646,0.00003983523,0.0001376923,0.0002386053,0.00008655793,0.0009941806,0.969636,0.00003416021,0.0079057,0.00001550471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828672,0.01438038,0.0004779896,0.00009401113,0.00009844241,0.00003844608,0.0003666149,0.00003075232,0.001646155],"genre_scores_gemma":[0.9900011,0.005581156,0.001530317,0.00009841683,0.00006328058,0.00004033483,0.0006687999,0.00002773941,0.001988861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138649,"threshold_uncertainty_score":0.004252434,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2026527102","doi":"10.1038/bjp.2008.297","title":"Can the anti‐inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?","year":2008,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Apremilast; Medicine; Tolerability; COPD; Asthma; Pharmacology; Intensive care medicine; Disease; Immunology; Internal medicine; Adverse effect; Psoriatic arthritis","authors":[{"name":"M A Giembycz","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01004422135191403,"gpt":0.2508203963237004,"spread":0.2407761749717864,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01865415,0.0007147299,0.001922086,0.0006947522,0.002209568,0.01098418,0.001821266,0.008105843,0.01051452],"category_scores_gemma":[0.0283169,0.0004826947,0.001458467,0.0004603979,0.01820291,0.01882423,0.004722411,0.0223875,0.004925894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003084839,"about_ca_system_score_gemma":0.007366286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120903,"about_ca_topic_score_gemma":0.001875124,"domain_scores_codex":[0.9932853,0.003523369,0.0002926301,0.0005912951,0.001360538,0.0009469505],"domain_scores_gemma":[0.9782701,0.01256013,0.001738706,0.001197292,0.002456842,0.003777097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001419065,0.0006359808,0.002360302,0.002918656,0.0004150384,0.001343209,0.005946097,0.0009982456,0.004168703,0.2971323,0.3581993,0.3244632],"study_design_scores_gemma":[0.0002401389,0.0004516586,0.0008896031,0.002461691,0.000105831,0.0008566676,0.004632411,0.0007462765,0.001286138,0.5584119,0.4297437,0.0001738893],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004234656,0.1231731,0.004415663,0.8454042,0.00941142,0.00003024064,0.00009902134,0.0001674828,0.0130641],"genre_scores_gemma":[0.1968088,0.2439872,0.01044787,0.5107028,0.02195973,0.0002173126,0.0002457963,0.0002934699,0.01533702],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01865415,"threshold_uncertainty_score":0.09865379,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2038550935","doi":"10.1165/ajrcmb.26.6.4743","title":"PDE4 Inhibitors Attenuate Fibroblast Chemotaxis and Contraction of Native Collagen Gels","year":2002,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Chemotaxis; Contraction (grammar); Fibroblast; Chemistry; Cell biology; Biophysics; Medicine; Biochemistry; Internal medicine; Biology; In vitro","authors":[{"name":"Tadashi Kohyama","is_ca":true},{"name":"Xiangde Liu","is_ca":true},{"name":"Fuqiang Wen","is_ca":true},{"name":"Yun Zhu","is_ca":true},{"name":"Hangjun Wang","is_ca":true},{"name":"Hui Jung Kim","is_ca":true},{"name":"Hajime Takizawa","is_ca":true},{"name":"L B Cieslinski","is_ca":true},{"name":"Mary S. Barnette","is_ca":true},{"name":"Stephen I. Rennard","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006036821601962194,"gpt":0.2261109575021098,"spread":0.2200741359001476,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982396,0.0005137951,0.0003694586,0.0002307233,0.0001365657,0.0002819779,0.0002026018,0.000260532,0.001356541],"category_scores_gemma":[0.0002069731,0.0001947524,0.000270675,0.00008922843,0.0001538746,0.0001380708,0.0001715607,0.0005364738,0.0002821376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003161532,"about_ca_system_score_gemma":0.0003779457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001586312,"about_ca_topic_score_gemma":0.003429736,"domain_scores_codex":[0.9998242,0.00004198585,0.0000127426,0.00001805529,0.00003535277,0.00006762464],"domain_scores_gemma":[0.999841,0.0000368893,0.00004441597,0.00001096799,0.00001702121,0.00004964679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004786813,0.00009539276,0.00009574493,0.00005861153,0.000009315237,0.00004011674,0.00001442214,0.00009825092,0.996825,0.00003212364,0.00009426395,0.002158181],"study_design_scores_gemma":[0.0001566167,0.003042383,0.008159441,0.00001435584,0.00003951228,0.0002255882,0.00004812,0.002291479,0.983451,0.00003313512,0.002530179,0.000008197006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899226,0.005416051,0.0020807,0.0001496266,0.00008998745,0.0000508224,0.0002439343,0.0001273368,0.001918926],"genre_scores_gemma":[0.9882966,0.00320399,0.00317107,0.000164396,0.00005397696,0.00008978388,0.0003888411,0.00002127385,0.004610215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586312,"threshold_uncertainty_score":0.004538059,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2234382447","doi":"10.1038/mp.2015.194","title":"Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits","year":2016,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke","keywords":"DISC1; Dopamine transporter; Dopamine; Dopamine Plasma Membrane Transport Proteins; Amphetamine; Neuroscience; Schizophrenia (object-oriented programming); Dopamine receptor; Dopamine receptor D2; Dopaminergic; Biology; Psychology; Psychiatry; Genetics; Gene","authors":[{"name":"Svenja V. Trossbach","is_ca":false},{"name":"Verian Bader","is_ca":false},{"name":"Laura Hecher","is_ca":false},{"name":"M.E. Pum","is_ca":false},{"name":"Shababa T. Masoud","is_ca":true},{"name":"Ingrid Prikulis","is_ca":false},{"name":"Sandra Schäble","is_ca":false},{"name":"M A de Souza Silva","is_ca":false},{"name":"Ping Su","is_ca":true},{"name":"Benoit Boulat","is_ca":false},{"name":"Caroline Chwiesko","is_ca":false},{"name":"Gereon Poschmann","is_ca":false},{"name":"Kai Stühler","is_ca":false},{"name":"Kelly M. Lohr","is_ca":false},{"name":"Kristen A. Stout","is_ca":false},{"name":"Angela Oskamp","is_ca":false},{"name":"Susan F. Godsave","is_ca":false},{"name":"Andreas Müller‐Schiffmann","is_ca":false},{"name":"Thomas Bilzer","is_ca":false},{"name":"Heinz Steiner","is_ca":false},{"name":"Peter J. Peters","is_ca":false},{"name":"Andreas Bauer","is_ca":false},{"name":"Magdalena Sauvage","is_ca":false},{"name":"Amy J. Ramsey","is_ca":true},{"name":"Gary W. Miller","is_ca":false},{"name":"F Liu","is_ca":true},{"name":"Philip Seeman","is_ca":true},{"name":"Nicholas J. Brandon","is_ca":false},{"name":"J.P. Huston","is_ca":false},{"name":"Carsten Korth","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008872192027705214,"gpt":0.2576028341781971,"spread":0.2487306421504919,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125899,0.001092884,0.0002711419,0.0007447596,0.0002446022,0.0001881755,0.0001995118,0.000421372,0.001322428],"category_scores_gemma":[0.0001590239,0.0002732857,0.0002805663,0.0002292158,0.0004496593,0.0001172449,0.0003608512,0.0005398435,0.0002263988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236265,"about_ca_system_score_gemma":0.0002430944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001425775,"about_ca_topic_score_gemma":0.001985414,"domain_scores_codex":[0.999856,0.00002085852,0.00002215113,0.0000403557,0.00003645239,0.00002411344],"domain_scores_gemma":[0.9996843,0.00002055455,0.0001850328,0.00001439846,0.00001113005,0.00008455452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003062418,0.00007605142,0.0024513,0.00003446453,0.00002415518,0.0009002681,0.00003032771,0.00006893073,0.9951211,0.00007038652,0.00004214338,0.0008744779],"study_design_scores_gemma":[0.0001100008,0.002342233,0.2406494,0.00003419769,0.0001880866,0.02074824,0.0001977281,0.003415265,0.7298326,0.000325427,0.002116166,0.00004061355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985323,0.0002646234,0.0006994901,0.00004159774,0.00001042071,0.000007559455,0.0002554972,0.00004319072,0.0001452325],"genre_scores_gemma":[0.997874,0.0002958134,0.0008532447,0.00003212765,0.000006549776,0.000008488328,0.0003574399,0.00001426933,0.0005580785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425775,"threshold_uncertainty_score":0.004423916,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}