{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":304,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":304,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"query_hash":"30e76170b2a6","filters":{"topic":"Plant-derived Lignans Synthesis and Bioactivity"}},"results":[{"id":"W2138640725","doi":"10.1007/s11103-005-2226-y","title":"Dirigent Proteins in Conifer Defense: Gene Discovery, Phylogeny, and Differential Wound- and Insect-induced Expression of a Family of DIR and DIR-like Genes in Spruce (Picea spp.)","year":2006,"lang":"en","type":"article","venue":"Plant Molecular Biology","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":213,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Forest Service; Natural Sciences and Engineering Research Council of Canada; Ministry of Forests, Lands and Natural Resource Operations; Genome British Columbia","keywords":"Biology; Phloem; Gene; Gene family; Gymnosperm; Subfamily; Botany; Gene expression; Gene expression profiling; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.01131369629064782,"gpt":0.2207088144861236,"spread":0.2093951181954758,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014164,0.0002505003,0.0004439637,0.0001209726,0.00003036357,0.00001417844,0.0001022833,0.0003015769,0.000001493005],"category_scores_gemma":[0.00002193743,0.0002045243,0.00004998428,0.00006438189,0.0002079024,0.000007757063,0.0002096502,0.00009794423,9.895385e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009071424,"about_ca_system_score_gemma":0.00004260772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213189,"about_ca_topic_score_gemma":0.0009894622,"domain_scores_codex":[0.9985384,0.0002084434,0.0003676399,0.0005119354,0.0000867796,0.0002867688],"domain_scores_gemma":[0.9995081,0.0000378353,0.0001709156,0.0002075198,0.00002309309,0.00005251395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000355964,0.000177761,0.06984056,0.00006620025,0.00003070036,0.00002527739,0.00002217087,0.000002136637,0.9286348,0.0000612681,0.000004139308,0.0007790803],"study_design_scores_gemma":[0.0008638956,0.0002865769,0.1544996,0.00005061127,0.0000183058,0.0000426918,0.000019757,0.00002174915,0.8437569,0.00008976497,0.0001469018,0.0002033149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991014,0.007460717,0.0006583385,0.0000141143,0.0000457346,0.0003948911,0.0003798604,0.000003789676,0.00002853499],"genre_scores_gemma":[0.9983822,0.0009456426,0.0003381504,0.00002589296,0.00003050684,0.00003100311,0.0002229715,0.00001507331,0.000008541363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0848779,"threshold_uncertainty_score":0.834026,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2006764912","doi":"10.1002/anie.201302327","title":"Total Synthesis of (+)‐Linoxepin by Utilizing the Catellani Reaction","year":2013,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Austrian Science Fund; University of Toronto; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Combinatorial chemistry; Lignan; Total synthesis; Stereochemistry; Metathesis; Moiety; Organic chemistry; Polymer","retraction":null,"screen_n_in":null,"score":{"opus":0.00978834161081564,"gpt":0.223681848049735,"spread":0.2138935064389194,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261358,0.0001046593,0.00009264544,0.00002413975,0.00005375081,0.00002512323,0.0001552943,0.0001056765,0.000128885],"category_scores_gemma":[0.0001211553,0.00007860066,0.00008172524,0.0000364198,0.00006741764,0.00001857653,0.00004451221,0.00006568943,0.00001879947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002382427,"about_ca_system_score_gemma":0.00001913297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002616305,"about_ca_topic_score_gemma":0.00001105243,"domain_scores_codex":[0.99931,0.00002671738,0.0001739931,0.000191384,0.000181064,0.0001168467],"domain_scores_gemma":[0.9994989,0.00005860961,0.0001374518,0.0001481378,0.0001252588,0.00003166352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000250099,0.00005800712,0.0002953212,0.000006255943,0.00005998298,2.568833e-7,0.00001322307,9.439544e-7,0.966048,0.00001998426,0.03111761,0.002355402],"study_design_scores_gemma":[0.00009333477,0.00002609913,0.003585363,0.00002125518,0.00001433692,0.00001792304,0.000149706,0.0000288386,0.9862592,0.00004959637,0.009660924,0.00009339482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850491,0.0001216542,0.0004152807,0.001310627,0.0004844929,0.0001458536,0.0002117112,0.00001391003,0.0122474],"genre_scores_gemma":[0.9982395,0.0002073641,0.00005949766,0.0001105577,0.0005769202,0.00005605842,0.0004311067,0.00001009496,0.0003088767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02145668,"threshold_uncertainty_score":0.3205242,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2052486577","doi":"10.1007/s11101-006-9025-1","title":"Cytochromes P450 in phenolic metabolism","year":2006,"lang":"en","type":"article","venue":"Phytochemistry Reviews","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Phenylpropanoid; Lignin; Shikimate pathway; Biochemistry; Hydroxylation; Monolignol; Cytochrome P450; Biosynthesis; Enzyme; Chemistry; Monooxygenase; Secondary metabolism; Biology; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.0128163969221614,"gpt":0.2426039607695438,"spread":0.2297875638473824,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018045,0.0002784512,0.0004521549,0.0000291923,0.0000483834,0.00002639495,0.0002710156,0.0002394146,0.00006175736],"category_scores_gemma":[0.00006557629,0.0002380897,0.0002042962,0.0001443789,0.00006945219,0.000006389136,0.00008361201,0.0001736565,0.00004531354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002025674,"about_ca_system_score_gemma":0.00004695789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005688234,"about_ca_topic_score_gemma":0.00005462597,"domain_scores_codex":[0.9985237,0.00008280824,0.0004184385,0.0004905403,0.0001195023,0.0003650395],"domain_scores_gemma":[0.9992188,0.0000126981,0.0001677036,0.0005076276,0.00002635774,0.00006684216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001883727,0.0001221995,0.0007267052,0.00008472658,0.00001115965,0.000003971585,0.000004452144,0.000002558701,0.9898917,0.00001989174,0.004759738,0.004354079],"study_design_scores_gemma":[0.0002324126,0.00001083924,0.005950545,0.0000526626,0.00001522654,0.00001901144,0.000005303078,0.00000419521,0.6814501,0.00007770283,0.3119439,0.0002380646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9421812,0.04006809,0.0001891319,0.0001434307,0.000061222,0.0004699162,0.00005903352,0.00002367718,0.01680428],"genre_scores_gemma":[0.9934382,0.003812425,0.0006519329,0.0001772118,0.0006863148,0.0001571718,0.0001825226,0.00002384781,0.00087032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3084416,"threshold_uncertainty_score":0.9709014,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1968445402","doi":"10.1021/jf990922p","title":"Quantitation of the Lignan Secoisolariciresinol Diglucoside in Baked Goods Containing Flax Seed or Flax Meal","year":2000,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Agriculture and Agri-Food Canada","funders":"","keywords":"Lignan; Food science; Chemistry; Meal; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01053002026992885,"gpt":0.2070924253156173,"spread":0.1965624050456884,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490633,0.0001426617,0.0002389391,0.00001175596,0.00006034763,0.00002377569,0.0001656666,0.0001555134,0.0000214566],"category_scores_gemma":[0.00004466037,0.00007017799,0.0001264091,0.000096219,0.0000572996,0.00001639089,0.00003343202,0.0001637854,2.189737e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001820667,"about_ca_system_score_gemma":0.00005965175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001755992,"about_ca_topic_score_gemma":0.00008171083,"domain_scores_codex":[0.9991357,0.00004864737,0.0003670968,0.0001381504,0.0001526404,0.0001577132],"domain_scores_gemma":[0.9994531,0.00003148505,0.0002924074,0.00009144574,0.00007114177,0.00006046374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002217388,0.00008066314,0.003959298,0.00004090478,0.00007351341,0.000002467059,0.0001122679,0.00002692223,0.9944219,0.000001675728,0.00009843118,0.0009602386],"study_design_scores_gemma":[0.0005535043,0.0003315982,0.1936904,0.0001123596,0.0000314437,0.0002265666,0.0005490881,0.000005425612,0.8040601,0.000007512174,0.0003212914,0.0001106463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985739,0.0005410521,0.000003390722,0.0001839161,0.00003612791,0.0000632353,0.00002096361,0.000002177395,0.000575229],"genre_scores_gemma":[0.9991767,0.0002826096,0.00008206429,0.00003084731,0.000145984,0.000001554475,0.00001048612,0.000005108604,0.0002646028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1903618,"threshold_uncertainty_score":0.2861775,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2470676528","doi":"10.1002/anie.201604528","title":"Copper‐Catalyzed Formal [2+2+1] Heteroannulation of Alkenes, Alkylnitriles, and Water: Method Development and Application to a Total Synthesis of (±)‐Sacidumlignan D","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; École Polytechnique Fédérale de Lausanne","keywords":"Domino; Catalysis; Chemistry; Copper; Cascade reaction; Quaternary carbon; Total synthesis; Combinatorial chemistry; Annulation; Formal synthesis; Organic chemistry; Enantioselective synthesis","retraction":null,"screen_n_in":null,"score":{"opus":0.007959204192236299,"gpt":0.2369077896404871,"spread":0.2289485854482508,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441524,0.0001152809,0.0001508316,0.00007210686,0.00003795254,0.00000887654,0.00007724309,0.00009536414,0.000008961272],"category_scores_gemma":[0.00006192012,0.00008027005,0.00003708682,0.00002808192,0.0000491303,0.00003050475,0.00009490355,0.00001970559,0.000001272746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002228952,"about_ca_system_score_gemma":0.00002024958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003150098,"about_ca_topic_score_gemma":0.0000159836,"domain_scores_codex":[0.9992051,0.00002173197,0.0002490731,0.0002452532,0.0001576834,0.0001212231],"domain_scores_gemma":[0.9995455,0.00004838283,0.000120244,0.0001074616,0.0001226896,0.00005570549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001396879,0.00004530772,0.0008832604,0.0000253804,0.000067513,2.446806e-7,0.00006557875,0.000002387883,0.9479169,0.00003098991,0.00009079184,0.05073198],"study_design_scores_gemma":[0.0002970575,0.00004497862,0.005839573,0.00006863722,0.0000189593,0.00002140632,0.00003860086,0.00002076624,0.9912345,0.00003389277,0.00226393,0.0001177237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9370174,0.0000478048,0.06207063,0.0002821192,0.00006658339,0.0001426522,0.0002285542,0.000006415052,0.0001378461],"genre_scores_gemma":[0.9959606,0.00007073658,0.003397371,0.00002563541,0.000140091,0.00006258746,0.000305528,0.000008949922,0.00002853068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05894318,"threshold_uncertainty_score":0.3273318,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1984159313","doi":"10.1186/1471-2229-14-82","title":"Identification and functional characterization of a flax UDP-glycosyltransferase glucosylating secoisolariciresinol (SECO) into secoisolariciresinol monoglucoside (SMG) and diglucoside (SDG)","year":2014,"lang":"en","type":"article","venue":"BMC Plant Biology","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Saskatchewan Research Council (Canada); University of Alberta; University of Prince Edward Island; Agriculture and Agri-Food Canada","funders":"Genome Prairie; University of Alberta; Genome Canada","keywords":"Aglycone; Glycosyltransferase; Biochemistry; Biology; Glycosylation; Biosynthesis; Glucuronidation; Uridine diphosphate; Gene; Enzyme; Glycoside; Botany","retraction":null,"screen_n_in":null,"score":{"opus":0.009707946875094589,"gpt":0.2034773381558036,"spread":0.193769391280709,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004597136,0.0002912212,0.0003772507,0.000137702,0.0002024162,0.00004486845,0.0001270821,0.0003741074,0.00001216365],"category_scores_gemma":[0.0001586526,0.0002659589,0.00007604256,0.00009252479,0.0001773809,0.00002785741,0.0001020012,0.0001375698,0.000003540572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001660865,"about_ca_system_score_gemma":0.00007017637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001523104,"about_ca_topic_score_gemma":0.000572806,"domain_scores_codex":[0.9981158,0.0003031467,0.0005069075,0.0006508332,0.0001070555,0.0003162272],"domain_scores_gemma":[0.9990674,0.0001582082,0.0002902435,0.0002933604,0.00008015865,0.0001106432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002935113,0.00007381834,0.04817287,0.0001016358,0.00005961784,8.094481e-7,0.00006324846,0.000003027032,0.9445109,0.0003127,0.00001928353,0.006388587],"study_design_scores_gemma":[0.0005383141,0.0002641202,0.2128534,0.00003342778,0.00004984551,0.00007522738,0.00002980041,0.001244525,0.7832447,0.0001755838,0.001201796,0.000289261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956795,0.0003216003,0.04192737,0.00007696004,0.0001529919,0.0002871259,0.0003519996,0.00002685021,0.00006007038],"genre_scores_gemma":[0.9971113,0.0004552287,0.0005157237,0.0001168144,0.0001839181,0.00003131133,0.001519789,0.00002470728,0.00004122082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1646805,"threshold_uncertainty_score":0.9999793,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4298111265","doi":"10.1002/advs.202202590","title":"Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Diabetic cardiomyopathy; Inflammation; In vivo; Pharmacology; Proinflammatory cytokine; In vitro; Gene silencing; Medicine; Chemistry; Cardiomyopathy; Heart failure; Immunology; Internal medicine; Biology; Gene; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.004400791095736652,"gpt":0.2084546114395402,"spread":0.2040538203438036,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007498598,0.0001266705,0.0001245351,0.00005324179,0.000713979,0.00005514803,0.0002179249,0.00002881723,0.000007034819],"category_scores_gemma":[0.0001679322,0.000124014,0.00003274465,0.00018967,0.0002119009,0.00003255399,0.0004023053,0.0001110981,0.000001704035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003851995,"about_ca_system_score_gemma":0.00006547278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001587542,"about_ca_topic_score_gemma":0.00000410942,"domain_scores_codex":[0.9986246,0.00007508387,0.0001652792,0.0004934857,0.000311356,0.0003301674],"domain_scores_gemma":[0.9995595,0.00002722921,0.0001165135,0.0001689371,0.00004457203,0.00008319875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001489612,0.00001324702,0.002737963,0.000006434191,0.000004195274,0.000002194706,0.00005445095,0.0003370379,0.9829607,0.00001939134,0.00003802698,0.01381146],"study_design_scores_gemma":[0.000216933,0.0001033175,0.001028963,0.00000882662,0.000005871102,0.00001757434,0.0003768977,0.0003345538,0.9937546,0.00003914241,0.003920152,0.0001931304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979379,0.0007227766,0.0005791852,0.0001347537,0.0001110903,0.0001426462,0.00005046048,0.00001712163,0.0003040977],"genre_scores_gemma":[0.9989002,0.00007180147,0.0007499097,0.00007234765,0.00005569317,0.00004232044,0.0000385118,0.000009606465,0.00005964879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01361833,"threshold_uncertainty_score":0.5491421,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2059272959","doi":"10.1139/v00-059","title":"Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"","keywords":"Lignan; Chemistry; Regioselectivity; Aryl; Human immunodeficiency virus (HIV); Organic chemistry; Virology; Catalysis","retraction":null,"screen_n_in":null,"score":{"opus":0.006349193219118392,"gpt":0.1931134719193109,"spread":0.1867642787001925,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824056,0.0001534866,0.0002577563,0.00003823603,0.00005877255,0.00001638495,0.0001939374,0.0001734123,0.0002153462],"category_scores_gemma":[0.00003605048,0.0001426129,0.0001232989,0.00006066231,0.0002064418,0.00001267486,0.00001211084,0.000136833,0.000001119246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000018336,"about_ca_system_score_gemma":0.0005080992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003315542,"about_ca_topic_score_gemma":0.0003397019,"domain_scores_codex":[0.9992048,0.00003052163,0.0002350658,0.0001734611,0.0001078412,0.0002483754],"domain_scores_gemma":[0.9992188,0.00001621668,0.0001813618,0.0001907932,0.00006782272,0.0003249998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007750902,0.00003407063,0.006063743,0.00004188511,0.00007072452,0.00006260739,0.00002578509,0.00000464033,0.9790869,6.099835e-7,0.0003521259,0.01417944],"study_design_scores_gemma":[0.0003083176,0.0001101547,0.008725489,0.0000694784,0.00002248216,0.000647505,0.00002637096,0.000004799371,0.9842418,0.00001952673,0.00566678,0.000157291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993307,0.001130181,0.000012799,0.0001213011,0.00003675316,0.0000350961,0.0001243725,0.000001406418,0.00523111],"genre_scores_gemma":[0.9988317,0.0003921201,0.00008734501,0.00002820019,0.0001779526,7.605007e-7,0.000008603473,0.00001331827,0.0004599399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01402215,"threshold_uncertainty_score":0.5815584,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2037811978","doi":"10.1002/anie.201408641","title":"A Bio‐Inspired Total Synthesis of Tetrahydrofuran Lignans","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; McGill University","keywords":"Lignan; Pinoresinol; Oxidative coupling of methane; Ferulic acid; Total synthesis; Phenols; Chemistry; Propenyl; Tetrahydrofuran; Biomimetic synthesis; Broad spectrum; Stereochemistry; Combinatorial chemistry; Organic chemistry; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01741482165102744,"gpt":0.2423371069407709,"spread":0.2249222852897435,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784833,0.000134937,0.0001453403,0.00006162161,0.00002776379,0.00001787973,0.0001800351,0.0001422398,0.00004368931],"category_scores_gemma":[0.0002601809,0.0001246122,0.0001151616,0.00006108552,0.00008036996,0.00001731735,0.00005736486,0.00005396425,0.00001104783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000364911,"about_ca_system_score_gemma":0.00007164627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005452783,"about_ca_topic_score_gemma":0.00001657853,"domain_scores_codex":[0.9991021,0.0000249039,0.0002094196,0.0002492932,0.0002718081,0.0001425418],"domain_scores_gemma":[0.9993914,0.00003198229,0.0001377545,0.0001679561,0.0001804974,0.0000904297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235182,0.0001453111,0.000874277,0.00001005128,0.00009637132,0.000003593881,0.00003676929,0.000008431283,0.9894251,0.00002881201,0.007803975,0.001443789],"study_design_scores_gemma":[0.00031139,0.00008754747,0.001302192,0.00004238845,0.0000236661,0.00003275507,0.00009731254,0.00003036373,0.9895615,0.00007151687,0.008290702,0.0001486393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824662,0.0001381348,0.001694071,0.0005854851,0.0008036281,0.0001095498,0.0005229213,0.00002469419,0.01365529],"genre_scores_gemma":[0.9979453,0.00007306175,0.000281722,0.00007272928,0.0008886259,0.00002926172,0.0004426777,0.00001379859,0.0002528041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154791,"threshold_uncertainty_score":0.5081538,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2951869188","doi":"10.1021/jo0161025","title":"Acid-Catalyzed Cyclization of 2,3-Dibenzylidenesuccinates:  Synthesis of Lignans (±)-Cagayanin and (±)-Galbulin","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba","funders":"","keywords":"Chemistry; Catalysis; Lignan; Aryl; Organic chemistry; Acid catalysis; Combinatorial chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.006568068760507553,"gpt":0.2068254648823022,"spread":0.2002573961217947,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005907984,0.0001525796,0.0003290876,0.00002703335,0.00004745157,0.000008107005,0.0003175579,0.0001581531,0.0001050767],"category_scores_gemma":[0.0004484084,0.0001066105,0.0001042964,0.0001194048,0.0001345537,0.000009884514,0.00008247641,0.000107041,6.688289e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001463814,"about_ca_system_score_gemma":0.0001056654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009609384,"about_ca_topic_score_gemma":0.000008614455,"domain_scores_codex":[0.9989786,0.00007655688,0.0004855366,0.0001260041,0.0001882521,0.0001450507],"domain_scores_gemma":[0.9985214,0.0001118936,0.0008601392,0.0002713181,0.0001674506,0.00006779782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002651689,0.0001014359,0.001595289,0.0000790182,0.0001321836,0.000004013113,0.00007478207,0.000007978722,0.9962001,0.000001030111,0.00007972398,0.001459214],"study_design_scores_gemma":[0.0003492533,0.00006332422,0.001969908,0.0001147529,0.0001477008,0.0004903381,0.0003187718,0.00001149999,0.9962115,0.00002948434,0.000182532,0.0001109313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996976,0.001584868,0.0008833312,0.000196225,0.00002965673,0.00005031248,0.00002322657,0.000002688465,0.0002536473],"genre_scores_gemma":[0.9967508,0.002896683,0.0001505928,0.00001586827,0.0001160073,7.622651e-7,0.000005967209,0.00001713843,0.00004613063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001348282,"threshold_uncertainty_score":0.434745,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4249778854","doi":"10.1002/ange.201302327","title":"Total Synthesis of (+)‐Linoxepin by Utilizing the Catellani Reaction","year":2013,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Austrian Science Fund; University of Toronto; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Stereochemistry; Lignan; Combinatorial chemistry; Ring (chemistry); Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01091537191076156,"gpt":0.2123117248012405,"spread":0.2013963528904789,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426596,0.0001364329,0.0001522088,0.00001444971,0.00007093763,0.00001873689,0.0001544262,0.0001362312,0.00005449442],"category_scores_gemma":[0.00007981442,0.00009376038,0.00009697487,0.00005431769,0.00008885332,0.000007090973,0.00005864491,0.00007042282,0.00001892114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001106053,"about_ca_system_score_gemma":0.00002357375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003706492,"about_ca_topic_score_gemma":0.00001582373,"domain_scores_codex":[0.9992569,0.00003721676,0.0001665672,0.0002289323,0.0001111468,0.0001992157],"domain_scores_gemma":[0.9994345,0.00005866176,0.0001093737,0.0002971416,0.00005194497,0.00004842075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001806481,0.00004708664,0.0005190612,0.00001462447,0.00004871294,3.373892e-7,0.00001851411,2.291891e-7,0.9837828,0.000004293846,0.0129777,0.002568616],"study_design_scores_gemma":[0.00007956896,0.00003309116,0.002260926,0.00001544074,0.00002401261,0.00001526094,0.0002063409,0.000003901645,0.9884155,0.00001159581,0.008809239,0.0001250647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898629,0.00051364,0.00001421769,0.0003444082,0.0000578643,0.000138877,0.00005502886,0.00001127756,0.009001804],"genre_scores_gemma":[0.9988895,0.0003146542,0.00005836383,0.0000885555,0.0001151577,0.00003971273,0.00005715729,0.00001460525,0.000422317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009026594,"threshold_uncertainty_score":0.3823437,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3004405824","doi":"10.3390/molecules25030565","title":"Utilization of Nutmeg (Myristica fragrans Houtt.) Seed Hydrodistillation Time to Produce Essential Oil Fractions with Varied Compositions and Pharmacological Effects","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"National Institute of Standards and Technology; Utah Agricultural Experiment Station","keywords":"Nutmeg; Myristica fragrans; Essential oil; Traditional medicine; Chemistry; Biology; Botany; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.009601102879764942,"gpt":0.2334221254111972,"spread":0.2238210225314323,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004470571,0.000135029,0.0001658741,0.00002678748,0.0001055129,0.00002038499,0.00006619686,0.00008506677,0.00002132497],"category_scores_gemma":[0.00006917585,0.0001126642,0.00003570061,0.0001171924,0.00008607543,0.000005703049,0.00004406819,0.00005859014,0.000009054262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005654188,"about_ca_system_score_gemma":0.00003133215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001004778,"about_ca_topic_score_gemma":0.000003787188,"domain_scores_codex":[0.9992103,0.00009210376,0.0001293101,0.0003249173,0.0001136975,0.0001296574],"domain_scores_gemma":[0.9996184,0.00003569364,0.00006942019,0.0001004308,0.00006329955,0.0001127662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003137871,0.0001364613,0.0002628033,0.00004210226,0.00007719421,0.000004650959,0.00005574164,0.0002293613,0.9974537,0.00003347038,0.0002281339,0.001162597],"study_design_scores_gemma":[0.0003975784,0.0004647609,0.009008916,0.00002283147,0.0001364089,0.00000950351,0.00001151641,0.002299366,0.9860182,0.000006225129,0.001459314,0.0001653966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527839,0.00006935534,0.04515809,0.0009688632,0.00001981751,0.0002063691,0.0001290817,0.00002578735,0.0006386865],"genre_scores_gemma":[0.9975766,0.00002755771,0.001764839,0.0002581225,0.00008102985,0.00002219691,0.0002187199,0.00001262242,0.00003834182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04479262,"threshold_uncertainty_score":0.4594311,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1992662258","doi":"10.1002/jms.726","title":"Lignans in resin of <i>Araucaria angustifolia</i> by gas chromatography/mass spectrometry","year":2004,"lang":"en","type":"article","venue":"Journal of Mass Spectrometry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Oregon State University","keywords":"Chemistry; Mass spectrometry; Chromatography; Gas chromatography; Gas chromatography–mass spectrometry; Araucaria; Forestry","retraction":null,"screen_n_in":null,"score":{"opus":0.005445003080037668,"gpt":0.2157598579861227,"spread":0.210314854906085,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007550074,0.0003151587,0.0006716003,0.0006684167,0.00005056306,0.00003641679,0.0005004582,0.0003103666,0.00004974091],"category_scores_gemma":[0.0001399093,0.000275926,0.0004304032,0.000853486,0.0001475976,0.00002610752,0.00005349932,0.0004071388,0.000003398634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001212038,"about_ca_system_score_gemma":0.0002324865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005678436,"about_ca_topic_score_gemma":0.00003711404,"domain_scores_codex":[0.9976995,0.0001313105,0.0008132908,0.0003507309,0.0004946702,0.0005104939],"domain_scores_gemma":[0.9985127,0.00005237994,0.0007467918,0.0003865449,0.0001172106,0.0001843422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002781331,0.0004496445,0.01135657,0.00004337756,0.000211332,0.00009559466,0.00002509847,0.00002413688,0.9855545,0.0001141944,0.001704443,0.0001429943],"study_design_scores_gemma":[0.001527148,0.00115109,0.01274357,0.0001497222,0.00006781668,0.000252925,0.0001758271,0.000001934403,0.9817525,0.001028221,0.0008525751,0.0002966663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882713,0.004270359,0.005125419,0.0003826743,0.0002238117,0.0001254302,0.0001035925,0.000008054643,0.001489362],"genre_scores_gemma":[0.9843966,0.001705762,0.01340707,0.00007978112,0.0003170567,0.000002145692,0.00001754098,0.0000356424,0.00003837189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008281656,"threshold_uncertainty_score":0.9999693,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2894830330","doi":"10.2147/dddt.s167382","title":"Synthesis and anticancer activity of dimeric podophyllotoxin derivatives","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; National Key Research and Development Program of China; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Etoposide; Chemistry; Triazole; Cytotoxicity; MTT assay; Click chemistry; Combinatorial chemistry; Stereochemistry; Cell growth; In vitro; Biochemistry; Biology; Chemotherapy; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.02212688997490328,"gpt":0.2391790370952296,"spread":0.2170521471203263,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829667,0.0001640126,0.0001988715,0.00004244591,0.0001157544,0.00001715367,0.00008165024,0.00006796864,0.00001602372],"category_scores_gemma":[0.00002607753,0.0001292074,0.00002554608,0.00006717363,0.0002552551,0.000008683931,0.00004667122,0.00003399893,0.00000124651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004785454,"about_ca_system_score_gemma":0.00006900262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001287662,"about_ca_topic_score_gemma":0.000005694871,"domain_scores_codex":[0.9991965,0.0001208995,0.0001267766,0.000287571,0.00009613625,0.0001720608],"domain_scores_gemma":[0.9996061,0.00007970805,0.00008872079,0.0001263541,0.00004378463,0.00005531178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002672165,0.0000628575,0.003166885,0.000008628414,0.00009918522,5.635255e-7,0.0002954577,6.074455e-8,0.8412226,0.000009198495,0.00006699302,0.1548004],"study_design_scores_gemma":[0.0002232422,0.00009140431,0.04074411,0.00002141996,0.000006027147,0.000003647925,0.00004144256,0.00001202027,0.9530734,0.0000255703,0.005578286,0.0001793603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938849,0.0009385858,0.004733258,0.00006862816,0.00003985333,0.0001630469,0.000004817388,0.000008623222,0.0001582707],"genre_scores_gemma":[0.9914957,0.001962454,0.006284064,0.00006370924,0.00005382202,0.00002543704,0.000002434504,0.00001354386,0.00009881546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.154621,"threshold_uncertainty_score":0.5268927,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2125421419","doi":"10.1080/13880200490505474","title":"Isolation and Characterization of Compounds with Anti-prostate Cancer Activity from<i>Arctium lappa</i>L. Using Bioactivity-guided Fractionation","year":2004,"lang":"en","type":"article","venue":"Pharmaceutical Biology","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Arctium lappa; LNCaP; Fractionation; Chemistry; Prostate cancer; Traditional medicine; Cytotoxicity; Cancer cell lines; Cancer; Chromatography; Medicine; Cancer cell; Biochemistry; In vitro; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.03590570508202822,"gpt":0.3214845804034991,"spread":0.2855788753214709,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374129,0.0001778664,0.0002389214,0.00005829814,0.0001079449,0.00001594405,0.00006616727,0.0001842658,0.00001401578],"category_scores_gemma":[0.00001974719,0.0001492103,0.00003910256,0.0001027281,0.0002423988,0.00003096276,0.0000574006,0.0001264227,9.230179e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004005774,"about_ca_system_score_gemma":0.0000881618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004557087,"about_ca_topic_score_gemma":0.00004324358,"domain_scores_codex":[0.998998,0.0001338961,0.0001755084,0.0003910513,0.00008911302,0.0002124641],"domain_scores_gemma":[0.9994614,0.00004188299,0.0001956145,0.0001295506,0.00009431369,0.00007722049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003988279,0.0001580786,0.03920554,0.00001839905,0.0001055508,7.832314e-7,0.00002662555,0.00004470248,0.9569002,0.00004859194,0.000001743331,0.003091007],"study_design_scores_gemma":[0.0009113254,0.0001239633,0.08073694,0.00002132099,0.00006662401,0.00001446338,0.00001103077,0.0009059581,0.9161543,0.00006288287,0.000807825,0.0001833597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852758,0.00009598499,0.01330741,0.0005284075,0.0001338109,0.000211119,0.0003885482,0.00001537568,0.00004355938],"genre_scores_gemma":[0.9979511,0.0006117946,0.0007855991,0.0001542012,0.0001495721,0.000013929,0.0003150117,0.00001518704,0.000003581041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04153141,"threshold_uncertainty_score":0.6084622,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2129676001","doi":"10.5539/jfr.v4n1p51","title":"Major Antifungals in Nutmeg Essential Oil against Aspergillus flavus and A. ochraceus","year":2014,"lang":"en","type":"article","venue":"Journal of Food Research","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Nutmeg; Safrole; Aspergillus flavus; Aspergillus ochraceus; Myristica fragrans; Chemistry; Chromatography; Food science; Aflatoxin; Essential oil; Mycotoxin; Botany; Biology; Ochratoxin A","retraction":null,"screen_n_in":null,"score":{"opus":0.02411699050828329,"gpt":0.3087616363624439,"spread":0.2846446458541605,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002046986,0.0001168913,0.0002479504,0.0002109835,0.0001041023,0.00006380399,0.0002487422,0.000175261,0.000007736485],"category_scores_gemma":[0.0004681931,0.00009004282,0.0001087971,0.0001371661,0.0001498023,0.00001144466,0.0001392708,0.00038396,0.000004497833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002123245,"about_ca_system_score_gemma":0.0001301508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001369923,"about_ca_topic_score_gemma":0.0001246064,"domain_scores_codex":[0.9982278,0.0004594992,0.0003080082,0.0002159402,0.0004253158,0.0003634753],"domain_scores_gemma":[0.999202,0.0001085115,0.0001282832,0.0001929239,0.0002161381,0.0001521329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002655756,0.0001386354,0.001084189,0.0000367613,0.00007450338,0.00003320602,0.00003968723,0.000005443483,0.9818349,0.00003343051,0.0006510946,0.01580256],"study_design_scores_gemma":[0.001051346,0.001115096,0.00485159,0.00010887,0.00001149785,0.0001493921,0.000131022,0.00005422278,0.9822873,0.00007334695,0.01001926,0.0001470189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956142,0.002123457,0.00004870025,0.0004981727,0.0001111476,0.00004615888,0.00001373929,0.000001764524,0.001542649],"genre_scores_gemma":[0.9973768,0.001720601,0.0002095578,0.00004147697,0.0004583558,0.000002225702,0.000005371242,0.00001335733,0.0001722453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01565554,"threshold_uncertainty_score":0.367184,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2951914250","doi":"10.1055/s-2006-926244","title":"Preparation of the Neolignan Natural Product Grossamide by a Continuous-Flow Process","year":2006,"lang":"en","type":"article","venue":"Synlett","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Natural product; Flow chemistry; Continuous flow; Process (computing); Product (mathematics); Organic chemistry; Combinatorial chemistry; Biochemical engineering; Catalysis; Programming language","retraction":null,"screen_n_in":null,"score":{"opus":0.003164529426340241,"gpt":0.2237581962240696,"spread":0.2205936667977294,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255003,0.0001270916,0.0001363687,0.00001208016,0.00007602858,0.00001673455,0.0001914111,0.00007474673,0.000004425473],"category_scores_gemma":[0.00004755082,0.00008440562,0.00008628692,0.0000726513,0.000106385,0.00000610539,0.00004185316,0.00006506652,0.000001819163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000757511,"about_ca_system_score_gemma":0.00004977178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008466518,"about_ca_topic_score_gemma":0.00009430553,"domain_scores_codex":[0.9991667,0.00006558266,0.0001735422,0.0002706703,0.0001431641,0.0001802872],"domain_scores_gemma":[0.9994791,0.000009522749,0.0001393929,0.0002864876,0.00006722908,0.00001834187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005715528,0.0000819811,0.0032055,0.00002196753,0.0000184292,3.899465e-7,0.00001893418,0.00002223251,0.9824784,0.00001380387,0.01331075,0.0007703876],"study_design_scores_gemma":[0.0001533239,0.00005460626,0.004906319,0.00001881018,0.0000150492,0.00001342888,0.00001415973,0.00007400149,0.9852489,0.00005255094,0.009325327,0.0001235255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973413,0.0007421447,0.00009857918,0.000366729,0.0001260329,0.0002670056,0.00008526351,0.00001142302,0.0009614752],"genre_scores_gemma":[0.9984892,0.00001069999,0.00008879057,0.0001045919,0.0001863963,0.00002015664,0.0001023278,0.00001103547,0.0009868193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003985426,"threshold_uncertainty_score":0.3441961,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2050835577","doi":"10.1055/s-2005-916213","title":"Four New Lignans from the Stems of<i>Kadsura heteroclita</i><u/>","year":2006,"lang":"en","type":"article","venue":"Planta Medica","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Lignan; Natural product; Stereochemistry; Spectral analysis; Chemistry; Physics","retraction":null,"screen_n_in":null,"score":{"opus":0.01314670400654826,"gpt":0.2036527602798262,"spread":0.1905060562732779,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987816,0.0001594612,0.000207923,0.00001585802,0.00006922292,0.0000180945,0.0003484203,0.0001600208,0.00004567634],"category_scores_gemma":[0.00005078074,0.0001022328,0.0001074928,0.00004988624,0.0000986344,0.000003817845,0.00007829747,0.00009859772,0.00001632621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006126269,"about_ca_system_score_gemma":0.0001015279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002661442,"about_ca_topic_score_gemma":0.0007608421,"domain_scores_codex":[0.9988881,0.00008847538,0.0002508009,0.0002842302,0.0002462378,0.0002421909],"domain_scores_gemma":[0.9992454,0.0001410479,0.000133488,0.0003735378,0.00002086648,0.0000856554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007939618,0.00006074244,0.011173,0.000007583168,0.00008321235,0.00001100923,0.00003984854,0.000001980537,0.9142128,0.00002824127,0.07038049,0.0039217],"study_design_scores_gemma":[0.0005588559,0.0001231099,0.02714126,0.00007748546,0.00006471337,0.00005184732,0.00008733669,0.00002021127,0.7467517,0.0001573238,0.2247228,0.0002433792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928664,0.001397642,0.0009633756,0.0008416121,0.0002755208,0.0001423361,0.0005611444,0.00001610402,0.002935866],"genre_scores_gemma":[0.9974436,0.0003056029,0.0002204262,0.0002743263,0.0009733519,0.000005960193,0.0003546806,0.00001389284,0.0004081358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1674612,"threshold_uncertainty_score":0.4168931,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2059714799","doi":"10.1248/bpb.31.1312","title":"The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-&amp;kappa;B Activation in RAW264.7 Macrophage Cells","year":2008,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Nitric oxide synthase; Nitric oxide; Lipopolysaccharide; Western blot; Molecular biology; NFKB1; Chemistry; Transcription factor; Macrophage; NF-κB; Gene expression; Signal transduction; Biology; Biochemistry; Gene; In vitro; Immunology","retraction":null,"screen_n_in":null,"score":{"opus":0.0557591110724094,"gpt":0.2855236704611807,"spread":0.2297645593887712,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005286307,0.0003090476,0.0002492942,0.00002040579,0.0005963372,0.00005762964,0.00035712,0.0003764966,0.00007539089],"category_scores_gemma":[0.0002851391,0.0001533247,0.0001213558,0.00009709346,0.0003939893,0.000009768002,0.0003475343,0.0005127415,0.00004139456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001867323,"about_ca_system_score_gemma":0.00003154417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004712482,"about_ca_topic_score_gemma":0.000009139284,"domain_scores_codex":[0.9977739,0.0005684207,0.0003710316,0.0005624363,0.0002004407,0.0005237908],"domain_scores_gemma":[0.9990063,0.0004181863,0.0001231728,0.0002657385,0.0000526692,0.0001339336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003565494,0.0001233197,0.0005491594,0.00000878753,0.0000188305,0.000008049787,0.00006503992,0.000002459094,0.9931633,0.00005044005,0.001111941,0.004542151],"study_design_scores_gemma":[0.0004429251,0.0001161031,0.001453513,0.00003181128,0.000006572515,0.00002913352,0.00004513584,0.00001415798,0.8553555,0.00006447526,0.142209,0.000231657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959705,0.001108608,0.0002254804,0.001786921,0.0001490067,0.0004436696,0.000020927,0.00002134385,0.0002735562],"genre_scores_gemma":[0.9953837,0.002048751,0.0002142847,0.001874643,0.0002793476,0.00005477948,0.00002203812,0.00001379534,0.0001086486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1410971,"threshold_uncertainty_score":0.6252398,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1973151923","doi":"10.1016/j.ultsonch.2011.05.012","title":"Application of ultrasound as pretreatment for extraction of podophyllotoxin from rhizomes of Podophyllum peltatum","year":2011,"lang":"en","type":"article","venue":"Ultrasonics Sonochemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Sonication; Podophyllotoxin; Ultrasound; Podophyllum; Extraction (chemistry); Chemistry; Ultrasonic sensor; Rhizome; Chromatography; Particle size; Solvent; Materials science; Botany; Medicine; Biochemistry; Organic chemistry; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.01197075896671454,"gpt":0.241330364867737,"spread":0.2293596059010225,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421326,0.0002031208,0.0003268115,0.00002722372,0.00003125232,0.000004014027,0.000230753,0.0002780427,0.0000280191],"category_scores_gemma":[0.0001751192,0.0001983085,0.0002115098,0.00006728892,0.0001372898,0.000007944707,0.00002763515,0.00006639941,0.000001135469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002139077,"about_ca_system_score_gemma":0.0001192709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003442663,"about_ca_topic_score_gemma":0.00001415837,"domain_scores_codex":[0.9988428,0.00002738176,0.0004106453,0.0003781695,0.0001500064,0.0001909567],"domain_scores_gemma":[0.998594,0.0001511432,0.0005551449,0.0004750199,0.0001600175,0.00006470611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003831538,0.0005533117,0.007846607,0.0001356419,0.0001967549,2.75244e-7,0.0001145579,0.000003741834,0.9894458,0.00006822528,0.00006411974,0.001187792],"study_design_scores_gemma":[0.0004528129,0.0002996611,0.006095635,0.00003800299,0.000100881,0.00001034691,0.0003106126,0.00001870384,0.9918185,0.0003593728,0.0003177697,0.0001776675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926535,0.0004803542,0.004454628,0.00000711384,0.00004935272,0.0003179853,0.001073573,0.000008600828,0.0009548552],"genre_scores_gemma":[0.991179,0.0002681882,0.007793386,0.0000069468,0.00006360655,0.0000544469,0.0005248131,0.00002311514,0.00008649315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003338759,"threshold_uncertainty_score":0.8086784,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3175277055","doi":"10.3390/molecules26123659","title":"Essential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"","keywords":"Sabinene; Podophyllotoxin; Juniper; Chemotype; Essential oil; Cupressaceae; Limonene; Botany; Composition (language); Horticulture; Biology; Chemistry; Stereochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.007975333477891842,"gpt":0.2183249348742608,"spread":0.2103496013963689,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005710126,0.0001213614,0.0001759174,0.00002016608,0.00005915246,0.00003254826,0.00004925695,0.00008912171,0.0000221637],"category_scores_gemma":[0.0000183981,0.0001136378,0.000045499,0.00003564551,0.000156073,0.000005594687,0.0001227446,0.00004934385,8.171025e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003754199,"about_ca_system_score_gemma":0.00002925654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001457533,"about_ca_topic_score_gemma":0.0001180727,"domain_scores_codex":[0.9992951,0.0000892727,0.0001139644,0.0002995313,0.00008464239,0.0001174731],"domain_scores_gemma":[0.9996412,0.00002697563,0.0000626558,0.0001741757,0.00004590966,0.00004907285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005664739,0.00008457492,0.002270883,0.00001635391,0.00007355975,0.00001182818,0.00003110358,0.000001215981,0.9944135,0.0002132253,0.00007402029,0.002753074],"study_design_scores_gemma":[0.0003728765,0.00003140677,0.02688171,0.00002223979,0.00004179981,0.00002255993,0.00005290961,0.0000396973,0.9713762,0.0001002431,0.0009246607,0.0001337204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959716,0.001100242,0.00164579,0.0001762963,0.00005665813,0.00002472477,0.0002252122,0.000005828846,0.000793622],"genre_scores_gemma":[0.9973419,0.0005697173,0.001638166,0.00006273954,0.00008675098,0.000002365841,0.0001819874,0.000009085042,0.0001073285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02461082,"threshold_uncertainty_score":0.4634016,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2057021918","doi":"10.1021/np8001354","title":"Nordihydroguaiaretic Acid Autoxidation Produces a Schisandrin-like Dibenzocyclooctadiene Lignan","year":2008,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Nordihydroguaiaretic acid; Lignan; Autoxidation; Chemistry; Aqueous solution; Quinone; Organic chemistry; Lipoxygenase","retraction":null,"screen_n_in":null,"score":{"opus":0.0116627265884037,"gpt":0.2145092775312462,"spread":0.2028465509428425,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003741589,0.0002159395,0.0002936987,0.00011019,0.0001663147,0.00002762697,0.00029814,0.0001244837,0.000005816569],"category_scores_gemma":[0.0004120397,0.0001581403,0.0001445306,0.0001835608,0.0001203818,0.00003818013,0.00007257188,0.0002765847,0.000007542541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003002062,"about_ca_system_score_gemma":0.000207192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005250334,"about_ca_topic_score_gemma":0.000006426449,"domain_scores_codex":[0.9985217,0.0001092327,0.000401738,0.0003469041,0.0003317748,0.0002886882],"domain_scores_gemma":[0.9987591,0.00001343273,0.0004554127,0.0003103604,0.0003650943,0.00009658591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002283173,0.0001463393,0.0008232917,0.00002459514,0.00009283155,0.0000503491,0.00008927154,0.000008510307,0.9912745,0.000004130613,0.004463029,0.002794839],"study_design_scores_gemma":[0.0004140887,0.0004145812,0.009961024,0.00004674849,0.00003793592,0.001744388,0.00002492384,0.00001258255,0.9697782,0.00001404026,0.0173302,0.0002212428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993331,0.004176063,0.00003440865,0.001250775,0.0009390383,0.0001578692,0.000006659933,0.00001115054,0.00009303893],"genre_scores_gemma":[0.9962562,0.0004974037,0.001391397,0.0001175976,0.001216076,0.000002347701,0.00002300902,0.00001925209,0.0004767687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02149625,"threshold_uncertainty_score":0.6448776,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1976611945","doi":"10.1021/tx700205j","title":"Oxidation of the Lignan Nordihydroguaiaretic Acid","year":2007,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Nordihydroguaiaretic acid; Lignan; Chemistry; Organic chemistry; Lipoxygenase; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.04730973176050128,"gpt":0.3512650600636943,"spread":0.3039553283031931,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001601647,0.00008946969,0.0001437614,0.00007905401,0.00004681787,0.00000629825,0.0004144058,0.000298951,0.00002114813],"category_scores_gemma":[0.0007233832,0.00006466308,0.00006996227,0.0002830137,0.0004740273,0.000002886778,0.0002915479,0.000281042,0.00000594014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000507104,"about_ca_system_score_gemma":0.0001293331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002415383,"about_ca_topic_score_gemma":0.0001242946,"domain_scores_codex":[0.9985737,0.0001994562,0.000231406,0.0002821557,0.0002518294,0.0004614634],"domain_scores_gemma":[0.999287,0.0001497563,0.00005590337,0.0003417558,0.00008661586,0.00007895091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234057,0.0001510962,0.002357716,0.00001637674,0.000009323136,0.000004033132,0.00001912059,4.69077e-7,0.9905717,0.0001606743,0.0002124972,0.006373626],"study_design_scores_gemma":[0.0002116494,0.0001150945,0.007590234,0.00001974897,0.000002197634,0.0000109589,0.00004806485,0.000007798275,0.9894497,0.0003044879,0.002169895,0.00007019773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961097,0.0001422697,0.00008887281,0.0006022342,0.00006138285,0.0001906224,0.000007038499,0.000003362341,0.002794485],"genre_scores_gemma":[0.9995406,0.00004489737,0.0001459495,0.00007096952,0.00009896999,0.00001491814,0.00001352285,0.000008954235,0.00006126572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006303428,"threshold_uncertainty_score":0.2636884,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2048809849","doi":"10.3390/molecules181113992","title":"Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings","year":2013,"lang":"en","type":"article","venue":"Molecules","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Triazole; Chemistry; Stereochemistry; Combinatorial chemistry; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.008334826898277563,"gpt":0.2143229197036475,"spread":0.2059880928053699,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235529,0.0002204046,0.0002992509,0.00005739453,0.00007447647,0.00003083641,0.0001602405,0.0001792456,0.00004773686],"category_scores_gemma":[0.0001356898,0.0001890169,0.0000918259,0.00009366812,0.0002094151,0.00001498858,0.000132571,0.00008306342,0.00000815544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009381336,"about_ca_system_score_gemma":0.00003354085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002812716,"about_ca_topic_score_gemma":0.00002377733,"domain_scores_codex":[0.9988963,0.0001200317,0.0001949661,0.0003855914,0.0001374871,0.0002656209],"domain_scores_gemma":[0.9993144,0.00007605193,0.0001545879,0.0002825102,0.00007983781,0.00009263893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007975879,0.0001115079,0.002786872,0.00003559186,0.0001038968,0.000001826473,0.00002801348,0.000002697558,0.9790634,0.00001508585,0.00007237389,0.01769898],"study_design_scores_gemma":[0.0002022964,0.0001005856,0.1008454,0.00003141426,0.00002616158,0.000007107635,0.00002505271,0.0002366836,0.8979386,0.00006689683,0.0003076992,0.0002121164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964958,0.0003411857,0.002187765,0.0002026424,0.00003336596,0.0002598116,0.00004514044,0.00001884658,0.0004154364],"genre_scores_gemma":[0.9983664,0.0002590587,0.001126427,0.00006689139,0.00004711234,0.0000500899,0.00001066516,0.00002410286,0.00004927182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09805851,"threshold_uncertainty_score":0.7707885,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3026313717","doi":"10.1155/2020/7286053","title":"Proapoptotic and Antiangiogenic Activities of <i>Arctium Lappa</i> L. on Breast Cancer Cell Lines","year":2020,"lang":"en","type":"article","venue":"Scientifica","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Arctium lappa; Downregulation and upregulation; Cell growth; Cancer; MCF-7; Chemistry; Traditional medicine; Apoptosis; Cancer research; IC50; Cell culture; Breast cancer; Cell; Pharmacology; In vitro; Medicine; Biology; Biochemistry; Internal medicine; Human breast","retraction":null,"screen_n_in":null,"score":{"opus":0.01238281997330286,"gpt":0.2164232492584818,"spread":0.2040404292851789,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009831339,0.0001144542,0.0001364756,0.00001895376,0.00007359443,0.00002870536,0.0001262806,0.00006798359,0.00003343615],"category_scores_gemma":[0.00001155176,0.00009260459,0.00007003818,0.00008820116,0.0001609034,0.000006786256,0.00007145157,0.00004131164,0.000003450866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004593337,"about_ca_system_score_gemma":0.00005270462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003373516,"about_ca_topic_score_gemma":0.00003288969,"domain_scores_codex":[0.9991928,0.00003719469,0.0001114474,0.0003608063,0.0001281562,0.0001695413],"domain_scores_gemma":[0.999625,0.00001210511,0.00007608601,0.0001651292,0.00003444912,0.00008722419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009482451,0.00007689577,0.0008877002,0.00005739238,0.00002309202,7.066855e-7,0.00006462666,0.000005364153,0.9950685,0.000008019266,0.001975612,0.001737266],"study_design_scores_gemma":[0.0001471303,0.0000974076,0.003399596,0.00001759459,0.00002055314,0.000004201689,0.0001061301,0.00005788737,0.9917155,0.000002227479,0.004312842,0.0001189379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974613,0.0003938669,0.00003026698,0.0007471125,0.0001414555,0.0001164584,0.0004829457,0.00000992991,0.0006166209],"genre_scores_gemma":[0.9991072,0.0002113462,0.00008361936,0.0001788695,0.0001397804,0.000007429032,0.00002199388,0.00001009204,0.0002396099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003353009,"threshold_uncertainty_score":0.3776306,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2053659309","doi":"10.1016/s0040-4039(99)02100-0","title":"Biocatalytic dediastereomerization of dibenzylbutanolides by plant cell cultures","year":2000,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Organic chemistry; Stereochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.004289874531834276,"gpt":0.19187518965057,"spread":0.1875853151187357,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000063586,0.0001586343,0.0001579252,0.00003064924,0.0000435403,0.00001598361,0.0001649405,0.0000999989,0.0001009375],"category_scores_gemma":[0.000007146127,0.0001354348,0.00007636791,0.00006609763,0.00009176592,0.00000730375,0.00001891646,0.00005294322,0.00001711562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001008374,"about_ca_system_score_gemma":0.00001385914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004473106,"about_ca_topic_score_gemma":0.000008849269,"domain_scores_codex":[0.9991624,0.00003976295,0.0001869234,0.000267291,0.0001260528,0.0002175621],"domain_scores_gemma":[0.9996231,0.00001355718,0.00007887359,0.0002166897,0.00001087562,0.00005690299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005483083,0.00008136852,0.001169911,0.00002446725,0.00002505716,0.000002126076,0.00004130116,0.00002226809,0.9853597,0.000001243916,0.01017214,0.003045628],"study_design_scores_gemma":[0.0002289036,0.00008003125,0.001649251,0.00001437488,0.00001911355,0.00001032222,0.00003085007,0.00001848826,0.9836766,0.0000016136,0.01408973,0.0001807277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979295,0.000308058,0.0002582482,0.00022559,0.00004758254,0.0001033974,0.0003513533,0.0000147927,0.0007615072],"genre_scores_gemma":[0.9982758,0.0002827598,0.0001493476,0.0005102394,0.00007929933,0.000005934986,0.0004465048,0.00001611272,0.0002340359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003917593,"threshold_uncertainty_score":0.552287,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1977574969","doi":"10.1021/jo0497454","title":"A Short Asymmetric Synthesis of (+)-Lyoniresinol Dimethyl Ether","year":2004,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba","funders":"","keywords":"Dimethyl ether; Ether; Chemistry; Lignan; Chiral auxiliary; Organic chemistry; Methanol; Enantioselective synthesis; Catalysis","retraction":null,"screen_n_in":null,"score":{"opus":0.008218028272319742,"gpt":0.2178864561501657,"spread":0.209668427877846,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006645705,0.0001644631,0.0002866647,0.00003313111,0.00005697595,0.00001058169,0.0004860596,0.0001768085,0.00005703486],"category_scores_gemma":[0.000388568,0.0001071108,0.0001845251,0.0001893542,0.0001309138,0.00000584329,0.00009067135,0.0001999914,0.000002878108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003953684,"about_ca_system_score_gemma":0.0002019988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009196258,"about_ca_topic_score_gemma":0.000003241616,"domain_scores_codex":[0.9989613,0.00006609865,0.0003869827,0.0001270189,0.0002650784,0.000193548],"domain_scores_gemma":[0.9989969,0.0001052876,0.0003311258,0.000354009,0.0001313853,0.00008133196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001376386,0.0001472808,0.0003867385,0.00003309872,0.0001907592,0.000006627461,0.00003484535,0.00001428069,0.994438,0.000001737085,0.0001369036,0.004472124],"study_design_scores_gemma":[0.0002475693,0.00007652766,0.001992105,0.00006232742,0.0001461456,0.0004445433,0.000141509,5.925379e-7,0.9962054,0.00005630857,0.0004995644,0.0001274317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996093,0.001245651,0.0009762017,0.0002605772,0.0000542049,0.00005023493,0.000015577,0.000003920843,0.001300681],"genre_scores_gemma":[0.9986187,0.0005604604,0.0004583457,0.00003774344,0.0002266406,9.088351e-7,0.000001809346,0.00002283743,0.0000725787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004344692,"threshold_uncertainty_score":0.4367851,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4238161613","doi":"10.1002/ange.201604528","title":"Copper‐Catalyzed Formal [2+2+1] Heteroannulation of Alkenes, Alkylnitriles, and Water: Method Development and Application to a Total Synthesis of (±)‐Sacidumlignan D","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; École Polytechnique Fédérale de Lausanne","keywords":"Domino; Catalysis; Chemistry; Copper; Cascade reaction; Quaternary carbon; Total synthesis; Annulation; Combinatorial chemistry; Formal synthesis; Organic chemistry; Enantioselective synthesis","retraction":null,"screen_n_in":null,"score":{"opus":0.008746110578503661,"gpt":0.2278682283179995,"spread":0.2191221177394958,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002765995,0.0001417986,0.000230557,0.00004765845,0.00004631471,0.000006557671,0.00007234055,0.0001141236,0.000003480725],"category_scores_gemma":[0.00003802445,0.00009115814,0.00003936048,0.00003771554,0.00005781467,0.00001393923,0.0001219431,0.00001835797,0.000001007411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000114939,"about_ca_system_score_gemma":0.00002380744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003454003,"about_ca_topic_score_gemma":0.00002220467,"domain_scores_codex":[0.9991629,0.00002759853,0.0002406397,0.0002824314,0.0001008258,0.0001856701],"domain_scores_gemma":[0.9995367,0.00004456609,0.00009639245,0.0001852363,0.00005707084,0.00008001501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001146949,0.00003553564,0.001363557,0.00005347452,0.00005450507,2.718439e-7,0.00009152458,7.077913e-7,0.9321629,0.000006979562,0.00002929747,0.06608657],"study_design_scores_gemma":[0.0002839079,0.00005411635,0.00416756,0.00005251892,0.00002511944,0.00001787883,0.00004376287,0.000003700044,0.9930475,0.00000905564,0.002144747,0.0001501003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991829,0.0001950259,0.007481234,0.0001032308,0.00001179872,0.0001814726,0.00009716557,0.000006374621,0.000094672],"genre_scores_gemma":[0.9950831,0.00009026821,0.004624155,0.00001887397,0.00003080022,0.00005037322,0.00006048642,0.00001161387,0.0000303549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06593647,"threshold_uncertainty_score":0.3717321,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2738142696","doi":"10.1039/c7md00273d","title":"Click chemistry-assisted synthesis of triazolo linked podophyllotoxin conjugates as tubulin polymerization inhibitors","year":2017,"lang":"en","type":"article","venue":"MedChemComm","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"King Saud University; Institute of Population and Public Health; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Podophyllotoxin; HeLa; Tubulin; Apoptosis; Chemistry; Click chemistry; Colchicine; Conjugate; Cell cycle; Microtubule; Programmed cell death; Cell cycle checkpoint; Docking (animal); Cell; Biochemistry; Cell biology; Stereochemistry; Biology; Combinatorial chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01340645447092283,"gpt":0.2520174765856513,"spread":0.2386110221147285,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003481593,0.000282063,0.000432257,0.0000346029,0.0002715495,0.00007143578,0.0005843199,0.0003759304,0.00009702872],"category_scores_gemma":[0.00107924,0.0002561638,0.00022227,0.00005265404,0.0003044895,0.00001334145,0.0002127708,0.0001252349,0.00001678689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001782302,"about_ca_system_score_gemma":0.0001082328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002027104,"about_ca_topic_score_gemma":0.00002136126,"domain_scores_codex":[0.9984932,0.00009942336,0.0004219513,0.0004559412,0.0002216918,0.0003078014],"domain_scores_gemma":[0.9981573,0.00009080721,0.0005559061,0.0009719976,0.00008945035,0.0001345386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000238928,0.0002016926,0.003112593,0.00005747462,0.000112553,0.000004830101,0.00002124764,8.219587e-7,0.984353,0.000008700637,0.0003088583,0.01157926],"study_design_scores_gemma":[0.000564098,0.00009318532,0.008276216,0.0000772917,0.00005946528,0.00001897778,0.00005994772,0.00002696288,0.9864924,0.00002006727,0.004014137,0.0002972449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931344,0.0002363514,0.00005654262,0.0005690613,0.0001401597,0.0002039078,0.0001184542,0.0000254028,0.005515752],"genre_scores_gemma":[0.9984109,0.0001876527,0.0002881461,0.00007298577,0.0002966103,0.00004218673,0.0001238216,0.00003531613,0.0005423718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01128202,"threshold_uncertainty_score":0.999989,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1971289691","doi":"10.1055/s-2007-993754","title":"Reversal of P-Glycoprotein-Mediated Drug Efflux by Eudesmin from <i>Haplophyllum perforatum</i> and Cytotoxicity Pattern versus Diphyllin, Podophyllotoxin and Etoposide","year":2007,"lang":"en","type":"article","venue":"Planta Medica","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal","funders":"Novartis Pharma; Institut National de la Santé et de la Recherche Médicale","keywords":"Podophyllotoxin; Etoposide; Lignan; Cytotoxicity; Pharmacology; P-glycoprotein; Efflux; Multiple drug resistance; In vivo; Doxorubicin; IC50; Cancer cell; Chemistry; In vitro; Biochemistry; Biology; Medicine; Cancer; Chemotherapy; Stereochemistry; Internal medicine; Biotechnology","retraction":null,"screen_n_in":null,"score":{"opus":0.00564568416232078,"gpt":0.2071854396050956,"spread":0.2015397554427749,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005226198,0.000279785,0.0003694832,0.00004893264,0.00009244808,0.00002047249,0.0002009815,0.0002916522,0.00002818928],"category_scores_gemma":[0.0001675005,0.0002454048,0.00005973189,0.00007056328,0.0003043621,0.00001094299,0.0001574496,0.00022396,0.000004377769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001465926,"about_ca_system_score_gemma":0.00006063793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006909652,"about_ca_topic_score_gemma":0.000418871,"domain_scores_codex":[0.9983312,0.0001022766,0.0003466377,0.0005361298,0.0003079341,0.0003757525],"domain_scores_gemma":[0.9989194,0.0002998957,0.0001936017,0.0002806204,0.00003703349,0.000269496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007787075,0.0001145867,0.01659591,0.00004694366,0.0001222274,0.00002675752,0.00009939141,8.330758e-8,0.9765021,0.000001511465,0.003144042,0.002567761],"study_design_scores_gemma":[0.001703508,0.0003401824,0.01826365,0.00008223757,0.00005927903,0.00002351747,0.0001349569,0.00004023975,0.9742447,0.000005316492,0.00478856,0.0003138319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962901,0.001058453,0.0003533222,0.0001688861,0.0001702948,0.0002542769,0.001456938,0.00001756451,0.0002301003],"genre_scores_gemma":[0.9974973,0.001037052,0.0002526824,0.0002246244,0.00021315,0.00000925126,0.0006785691,0.0000250084,0.0000623254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257348,"threshold_uncertainty_score":0.9999998,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2078740602","doi":"10.1089/acm.2006.12.971","title":"Trial of Essiac to Ascertain Its Effect in Women with Breast Cancer (TEA-BC)","year":2006,"lang":"en","type":"article","venue":"The Journal of Alternative and Complementary Medicine","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true},"ca_institutions":"University of Toronto","funders":"Health Canada","keywords":"Medicine; Breast cancer; Traditional medicine; Cancer; Alternative medicine; Oncology; Family medicine; Gynecology; Internal medicine; Pathology","retraction":null,"screen_n_in":null,"score":{"opus":0.01231903372408185,"gpt":0.2809950354565749,"spread":0.2686760017324931,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007513124,0.0001103865,0.0002769005,0.00006069511,0.00003018253,0.000002978022,0.0001484817,0.00001690914,0.00005192146],"category_scores_gemma":[0.000009733423,0.00005410292,0.00001885071,0.00007547405,0.00007516069,0.000006682567,0.0000405797,0.00007598203,1.354027e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002613381,"about_ca_system_score_gemma":0.00003211644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968769,"about_ca_topic_score_gemma":0.0005593346,"domain_scores_codex":[0.9991099,0.0001867188,0.0002718943,0.00008897392,0.0001988515,0.0001437103],"domain_scores_gemma":[0.9994918,0.00006852841,0.0002344923,0.00007943908,0.00007324458,0.0000525224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.09369218,0.0002309696,0.01089498,0.00003526779,0.0003624413,0.00002161071,0.0007556708,0.0001133271,0.8727708,0.00001351504,0.001854317,0.01925487],"study_design_scores_gemma":[0.07299699,0.02745021,0.1843364,0.0009089536,0.0002624055,0.0002504085,0.002689222,0.000045504,0.7045441,0.0001670096,0.005990559,0.000358211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968615,0.0003269964,0.0001208993,0.002245362,0.0000677018,0.0002147848,0.00005276009,5.770707e-7,0.0001094194],"genre_scores_gemma":[0.9988016,0.0003675809,0.0000253296,0.0002573226,0.0005065693,0.000006900137,0.000005168949,0.000005628481,0.00002391547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1734414,"threshold_uncertainty_score":0.2976204,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1980343196","doi":"10.1016/j.intimp.2008.05.009","title":"Saucerneol D, a naturally occurring sesquilignan, inhibits LPS-induced iNOS expression in RAW264.7 cells by blocking NF-κB and MAPK activation","year":2008,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"MAPK/ERK pathway; Kinase; Nitric oxide synthase; Nitric oxide; Molecular biology; Chemistry; Lipopolysaccharide; NF-κB; Mitogen-activated protein kinase; Protein kinase A; Extracellular; Signal transduction; Cell biology; Biology; Biochemistry; Endocrinology","retraction":null,"screen_n_in":null,"score":{"opus":0.0114292247291561,"gpt":0.2495612861115531,"spread":0.238132061382397,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001942972,0.000224058,0.0002041193,0.0001341175,0.0001132819,0.00002513462,0.0002712129,0.0002551921,0.00005337971],"category_scores_gemma":[0.00005268041,0.0002193647,0.00006087041,0.00007556672,0.000079428,0.00003621824,0.0002037453,0.0002545801,0.000007947095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007326799,"about_ca_system_score_gemma":0.00007152033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008737055,"about_ca_topic_score_gemma":0.00001408883,"domain_scores_codex":[0.9985938,0.0001576093,0.0003217144,0.000459132,0.0001866336,0.0002811114],"domain_scores_gemma":[0.9994587,0.00007335278,0.0001847892,0.0001299711,0.00009292555,0.00006028946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002858847,0.0001602074,0.002695334,0.000008699412,0.00006840301,0.00002301095,0.0001250252,0.00002307132,0.9935505,0.000002517358,0.001334116,0.001723164],"study_design_scores_gemma":[0.001262422,0.00009645206,0.002442784,0.00005265123,0.000007993734,0.00008366727,0.00004557866,0.0002567613,0.9904643,0.00000648216,0.005039521,0.0002414293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981874,0.0003517545,0.0001129728,0.000186389,0.0005234898,0.0002386492,0.00004662369,0.00001819511,0.0003345786],"genre_scores_gemma":[0.9983647,0.0003443416,0.0002016443,0.0005708863,0.0001664872,0.0000424485,0.0001064704,0.00002040754,0.0001826173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003705406,"threshold_uncertainty_score":0.8945432,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2074127558","doi":"10.1016/j.jep.2012.04.002","title":"Adipogenic constituents from the bark of Larix laricina du Roi (K. Koch; Pinaceae), an important medicinal plant used traditionally by the Cree of Eeyou Istchee (Quebec, Canada) for the treatment of type 2 diabetes symptoms","year":2012,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true},"ca_institutions":"University of Ottawa; Canadian Institutes of Health Research; Ontario Genomics; Université de Montréal","funders":"Canadian Institutes of Health Research; Cree Board of Health and Social Services of James Bay","keywords":"Traditional medicine; Bark (sound); Botany; Triterpene; Chemistry; Pinaceae; Diterpene; Biology; Stereochemistry; Pinus <genus>; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.0173706097149653,"gpt":0.2529385961901851,"spread":0.2355679864752198,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006354338,0.0001718222,0.000406905,0.00002321608,0.0001050936,0.000004441598,0.0003943303,0.000129018,0.00005749788],"category_scores_gemma":[0.00008840581,0.00008248902,0.0001724774,0.00005836288,0.0003532403,0.00001136319,0.00002361656,0.000125345,9.275857e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000559277,"about_ca_system_score_gemma":0.0006804427,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01018976,"about_ca_topic_score_gemma":0.02640636,"domain_scores_codex":[0.9985635,0.0002414183,0.0005546786,0.0001242936,0.0002679147,0.0002482447],"domain_scores_gemma":[0.997878,0.0007988978,0.0008375397,0.0002048469,0.0001852021,0.00009556043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006748874,0.0005125001,0.01868153,0.00001164251,0.001361149,0.000003538326,0.000242472,0.00001691773,0.9683599,0.00003153556,0.009450199,0.0006536668],"study_design_scores_gemma":[0.001622466,0.001481837,0.06313679,0.00002395264,0.001000173,0.00001976074,0.0003884834,0.0001092003,0.9138641,0.00001995527,0.01821942,0.0001138267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856612,0.01080453,0.00006035265,0.001425536,0.000589034,0.0002652636,0.001180638,0.000001041196,0.00001240989],"genre_scores_gemma":[0.9977171,0.001354184,0.00003988955,0.0003362095,0.0004305912,0.000006663103,0.00009058943,0.00001087052,0.00001385589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05449583,"threshold_uncertainty_score":0.9964015,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2952505260","doi":"10.3389/fchem.2019.00434","title":"Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents","year":2019,"lang":"en","type":"article","venue":"Frontiers in Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lakehead University","funders":"Yunnan Provincial Science and Technology Department; National Natural Science Foundation of China","keywords":"Podophyllotoxin; Cytotoxic T cell; Apoptosis; Chemistry; Topoisomerase; Biotinylation; Cell culture; MTT assay; Cancer cell; Sulforhodamine B; Cell growth; Cytotoxicity; In vivo; Biochemistry; In vitro; Pharmacology; Biology; Cancer; Stereochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.02666721326949613,"gpt":0.2558242795749115,"spread":0.2291570663054154,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000569476,0.0001852342,0.0002834908,0.00003710702,0.0000306062,0.00001400563,0.0001718736,0.000273372,0.00005922684],"category_scores_gemma":[0.0002352673,0.0001652157,0.00006086129,0.00008798223,0.0001399747,0.000007836329,0.00008876568,0.00008927874,0.000001563407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002610695,"about_ca_system_score_gemma":0.00009940568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001021008,"about_ca_topic_score_gemma":3.45543e-7,"domain_scores_codex":[0.998779,0.0001171176,0.0002378036,0.0004352508,0.0002150947,0.0002157239],"domain_scores_gemma":[0.9994607,0.00002558228,0.0001563066,0.0002290065,0.00007321936,0.00005518902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000198773,0.0001878172,0.01731798,0.00004192791,0.00007309969,0.00000191453,0.00001415298,0.0001143581,0.9799137,7.439132e-7,0.0001510018,0.001984603],"study_design_scores_gemma":[0.0007537663,0.00006397844,0.01864444,0.00005467797,0.00003056565,0.00001749972,0.0001472588,0.002718532,0.9772604,0.00002452891,0.00008136193,0.0002030082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947094,0.0007076471,0.003661959,0.00002389904,0.0001200007,0.0002997786,0.00004772749,0.000007701533,0.0004219128],"genre_scores_gemma":[0.9951652,0.0002738987,0.00435809,0.00001939754,0.00004033604,0.00001884596,0.00005995983,0.00001309962,0.00005122551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002653246,"threshold_uncertainty_score":0.6737299,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2981956000","doi":"10.2147/dddt.s215895","title":"&lt;p&gt;Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity&lt;/p&gt;","year":2019,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lakehead University","funders":"National Natural Science Foundation of China","keywords":"Podophyllotoxin; Etoposide; Cytotoxicity; Chemistry; Stereochemistry; Cell culture; Glucoside; Acetylation; In vitro; Pharmacology; Biochemistry; Biology; Chemotherapy; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.02059583938527535,"gpt":0.2040505863657764,"spread":0.183454746980501,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328052,0.0003063328,0.0003801476,0.00005796856,0.00009788657,0.00003707689,0.0001733226,0.0001419998,0.00001668604],"category_scores_gemma":[0.0000281699,0.0002357449,0.00006054757,0.00007823003,0.0001601069,0.00001692381,0.00009250261,0.00006931469,0.000004747782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001304869,"about_ca_system_score_gemma":0.0001303598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002947641,"about_ca_topic_score_gemma":0.000002817824,"domain_scores_codex":[0.9986079,0.0001445143,0.0002804585,0.0004820246,0.0001923086,0.0002927704],"domain_scores_gemma":[0.9993955,0.00008297725,0.0001434195,0.0002296528,0.00005535264,0.00009309508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004369662,0.0001559888,0.00136243,0.00004714325,0.0001749897,0.000001466491,0.000341926,0.000001056943,0.9839662,0.00005203506,0.0001394688,0.01332029],"study_design_scores_gemma":[0.0005326216,0.0001038525,0.00482348,0.00008470938,0.000009362661,0.000009260929,0.00004842646,0.0000265279,0.9856559,0.0000402687,0.008306506,0.0003590919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946688,0.003966181,0.0004705327,0.00007369825,0.0000353194,0.0004683656,0.00001135886,0.00001752789,0.0002882346],"genre_scores_gemma":[0.9938168,0.00251701,0.003133909,0.0001046331,0.00005211503,0.00006502029,0.00001996356,0.00002963319,0.000260928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0129612,"threshold_uncertainty_score":0.96134,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4378078312","doi":"10.1002/efd2.90","title":"Myristicin: From its biological effects in traditional medicine in plants to preclinical studies and use as ecological remedy in plant protection","year":2023,"lang":"en","type":"article","venue":"eFood","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Agencia Nacional de Investigación y Desarrollo","keywords":"Traditional medicine; Myristica fragrans; Nutmeg; Hepatoprotection; Medicine; Medicinal plants; Antimicrobial; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.1487043670640907,"gpt":0.3241643152310458,"spread":0.1754599481669551,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000481079,0.0001483523,0.0003273683,0.0001150189,0.00002892058,0.000007541703,0.00008072858,0.0002429054,0.000007134711],"category_scores_gemma":[0.001916968,0.0001038088,0.00002389613,0.0001403656,0.00007557672,0.000005848367,0.0000911294,0.0001737579,0.00001187965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002896515,"about_ca_system_score_gemma":0.00002387016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001777827,"about_ca_topic_score_gemma":0.001855894,"domain_scores_codex":[0.998634,0.000285755,0.0002766569,0.000455062,0.0001096361,0.0002388634],"domain_scores_gemma":[0.9992015,0.0005756643,0.00004467379,0.00009506115,0.00001168323,0.00007136483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001125913,0.0003939697,0.08147115,0.00003975629,0.00005590537,0.0003344174,0.0002692793,0.00002151023,0.9137867,0.00006429385,0.0005545493,0.001882541],"study_design_scores_gemma":[0.001045305,0.001502575,0.940404,0.0002138258,0.000004863373,0.00001608886,0.0001447549,0.00007665667,0.05562557,0.0005691061,0.0002445726,0.0001527051],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980382,0.0003156218,0.000009621956,0.0008552876,0.0001154449,0.0004976135,0.0001215087,0.00001447339,0.00003217],"genre_scores_gemma":[0.9987476,0.0005183343,0.00006057368,0.0002050724,0.0001493827,0.0001399685,0.0001606853,0.000005908114,0.00001251689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8589329,"threshold_uncertainty_score":0.42332,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1978657122","doi":"10.1002/biof.179","title":"Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells","year":2011,"lang":"en","type":"article","venue":"BioFactors","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Glutathione; Cytoprotection; Chemistry; Glutathione reductase; Oxidative stress; Redox; Biochemistry; Cysteine; Buthionine sulfoximine; Pharmacology; Biology; Enzyme; Glutathione peroxidase","retraction":null,"screen_n_in":null,"score":{"opus":0.0134823915885515,"gpt":0.2123602154155827,"spread":0.1988778238270312,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148086,0.0001396158,0.0001751045,0.00003781065,0.00004567445,0.000009223447,0.0001203127,0.0001219139,0.000005739931],"category_scores_gemma":[0.00003250912,0.00007814926,0.00005032678,0.00005567362,0.00010788,0.000004398749,0.00006784726,0.00007952142,8.207606e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006447284,"about_ca_system_score_gemma":0.00001797592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007763646,"about_ca_topic_score_gemma":0.00006866664,"domain_scores_codex":[0.9993076,0.00007090125,0.0001693312,0.0002192015,0.00007818396,0.0001548134],"domain_scores_gemma":[0.9996611,0.00001405075,0.000104726,0.0001651422,0.00001652614,0.00003846013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009619971,0.00008764271,0.002598503,0.00001646086,0.00003560851,9.864957e-7,0.0002626559,5.117903e-7,0.995082,0.000007973686,0.00001579683,0.001795637],"study_design_scores_gemma":[0.0001087639,0.000110118,0.03550669,0.00004203172,0.0000100085,8.148967e-7,0.0001072926,0.000009479702,0.9635522,0.000009935289,0.0004298805,0.0001128049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992477,0.0001951083,0.00002415517,0.00002004111,0.00008419262,0.0002023659,0.00004456467,0.000005892106,0.0001759764],"genre_scores_gemma":[0.9992795,0.0004721952,0.0001383781,0.00002161004,0.00003667807,0.00001246928,0.000009241912,0.000008075829,0.00002187129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03290819,"threshold_uncertainty_score":0.3186834,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2146357430","doi":"10.1371/journal.pone.0106057","title":"Dual Extraction of Essential Oil and Podophyllotoxin from Creeping Juniper (Juniperus horizontalis)","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"Dalhousie University","funders":"U.S. Forest Service; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Wyoming; U.S. Department of Agriculture","keywords":"Juniper; Podophyllotoxin; Botany; Biology; Chemistry; Stereochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01652100099152344,"gpt":0.2091273601033339,"spread":0.1926063591118104,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288178,0.0001241319,0.0002133923,0.00003133748,0.00005821097,0.00001802921,0.00007338796,0.0001486057,0.0000261273],"category_scores_gemma":[0.00007222575,0.0001193575,0.00004966034,0.0000326636,0.00007618997,0.000009410516,0.00006448849,0.00007280175,0.000004006729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005806582,"about_ca_system_score_gemma":0.00001726647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002555568,"about_ca_topic_score_gemma":0.0001232468,"domain_scores_codex":[0.9991705,0.00008501177,0.0001596774,0.0002781416,0.0001566428,0.0001500371],"domain_scores_gemma":[0.9995365,0.00003835204,0.0001012442,0.0002175804,0.0000429304,0.00006346438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001087041,0.0004137154,0.001284158,0.00003375092,0.000147951,0.000001357284,0.0000279706,4.571027e-7,0.9923288,0.00002019595,0.00002358678,0.005609343],"study_design_scores_gemma":[0.000327882,0.0001668397,0.006360647,0.00006655738,0.00008674955,0.000003863531,0.0000408748,0.00008571566,0.9922505,0.00002243803,0.0004361062,0.0001518504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980469,0.0002152593,0.0001913974,0.00008612378,0.00004452382,0.00003615503,0.00008421933,0.00001115394,0.001284295],"genre_scores_gemma":[0.9974903,0.0004159551,0.00135066,0.00004042641,0.0003889623,0.00000673174,0.0001004208,0.0000152964,0.0001912172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005457493,"threshold_uncertainty_score":0.486726,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2072881042","doi":"10.1016/j.seppur.2008.03.041","title":"An optimum ethanol–water solvent system for extraction of podophyllotoxin: Experimental study, diffusivity determination and modeling","year":2008,"lang":"en","type":"article","venue":"Separation and Purification Technology","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Podophyllotoxin; Extraction (chemistry); Partition coefficient; Solvent; Chromatography; Yield (engineering); Chemistry; Thermal diffusivity; Particle size; Moisture; Analytical Chemistry (journal); Materials science; Thermodynamics; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.02658057748469508,"gpt":0.3049292888739175,"spread":0.2783487113892223,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654954,0.000103787,0.0001334476,0.0001034964,0.0001654612,0.00001158607,0.00005940021,0.0001874261,0.000001109004],"category_scores_gemma":[0.000009548417,0.00008971625,0.00002409614,0.00003856896,0.00007200598,0.00002155188,0.0000205651,0.00004074984,4.168655e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000133489,"about_ca_system_score_gemma":0.00001441575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104795,"about_ca_topic_score_gemma":0.000008004683,"domain_scores_codex":[0.9992762,0.00005340788,0.0002042479,0.000295617,0.00006636367,0.0001041552],"domain_scores_gemma":[0.9995986,0.000007133944,0.00009814828,0.0001873869,0.0000787582,0.00003001052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009821241,0.000336687,0.0006864459,0.00001750341,0.00001185499,3.975287e-7,0.0002054497,0.00005196476,0.9970452,0.00008694619,0.000002776567,0.001456579],"study_design_scores_gemma":[0.000421514,0.0007680305,0.0006106995,0.00000497176,0.00001350233,0.00004980687,0.001013941,0.0239985,0.9729202,0.00001998766,0.00007292454,0.0001059467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632725,0.0001533813,0.03588162,0.00007753181,0.00004482625,0.0005054888,0.00001484557,0.00003085778,0.0000189863],"genre_scores_gemma":[0.9983903,0.00006368465,0.001254067,0.000006631615,0.00003280365,0.0001391094,0.00008777052,0.000008740098,0.00001686464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03511787,"threshold_uncertainty_score":0.3658522,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1978259040","doi":"10.1007/s11829-012-9236-x","title":"Biological activities of lignans and neolignans on the aphid Myzus persicae (Sulzer)","year":2012,"lang":"en","type":"article","venue":"Arthropod-Plant Interactions","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Animal and Plant Health Inspection Service","keywords":"Myzus persicae; Aphid; Fecundity; Context (archaeology); Biology; Lignan; Botany; Population; Horticulture; Traditional medicine; Chemistry; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.02798134313341993,"gpt":0.2465681131274359,"spread":0.218586769994016,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740186,0.0001853687,0.00018424,0.00005159841,0.0002268496,0.00002087186,0.0001264377,0.0001039061,0.0001157569],"category_scores_gemma":[0.00007085366,0.0001158527,0.0001154116,0.00005879326,0.0002939375,0.00001850731,0.00007926881,0.0001557633,0.00001901661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001130607,"about_ca_system_score_gemma":0.00002228375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006165174,"about_ca_topic_score_gemma":0.00006892538,"domain_scores_codex":[0.9990535,0.000134834,0.0001804382,0.000230677,0.0001026934,0.0002978659],"domain_scores_gemma":[0.9992371,0.0002577754,0.0001180459,0.0002726131,0.00002606708,0.00008839683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001266635,0.0003420002,0.005019301,0.000006658906,0.000130133,0.000001596178,0.0003853302,0.000002011776,0.9865524,0.001691396,0.003950852,0.001791633],"study_design_scores_gemma":[0.000168716,0.0004168724,0.007967811,0.00005555619,0.00003795747,0.0001847448,0.00269058,0.00001791773,0.9006898,0.00004206823,0.08748607,0.0002419209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949337,0.0003108401,0.0001337596,0.0007254991,0.0002789012,0.0001510927,0.0003888321,0.00001603421,0.003061321],"genre_scores_gemma":[0.9982759,0.0007879179,0.00008429914,0.0002839071,0.0002578825,0.00002546856,0.00008170933,0.00001191351,0.0001910226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08586264,"threshold_uncertainty_score":0.4724337,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1981786006","doi":"10.3390/molecules20023255","title":"Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4β-Triazolopodophyllotoxin Derivatives","year":2015,"lang":"en","type":"article","venue":"Molecules","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Chemistry; Cytotoxicity; Cycloaddition; Stereochemistry; MTT assay; Residue (chemistry); Triazole; Etoposide; Click chemistry; Glycoside; Combinatorial chemistry; In vitro; Organic chemistry; Catalysis; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.02930071843879845,"gpt":0.2404764968221274,"spread":0.211175778383329,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003451678,0.0001816784,0.0003216723,0.00005965961,0.00003266029,0.00001014022,0.0001636753,0.0001573058,0.000004871803],"category_scores_gemma":[0.0004160987,0.0001535462,0.00006919574,0.00008821999,0.0002578625,0.000006555169,0.0001093052,0.00005005186,9.133672e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007670523,"about_ca_system_score_gemma":0.00008885824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000035669,"about_ca_topic_score_gemma":0.000008564061,"domain_scores_codex":[0.9988827,0.0002240916,0.0002655721,0.0002832175,0.0001550242,0.0001894114],"domain_scores_gemma":[0.9992523,0.00009451724,0.0001930499,0.0002437933,0.0001213906,0.00009493135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002773675,0.0001192025,0.002377207,0.00003703651,0.00009350601,0.000002624618,0.00007718237,0.00004420074,0.9960896,0.00003671601,0.0001060395,0.000739345],"study_design_scores_gemma":[0.0002907267,0.0003323825,0.005374542,0.00004245163,0.00003033386,0.000008823517,0.000138508,0.0001426961,0.9932836,0.00009145369,0.00009430517,0.0001701458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914026,0.0009089406,0.00710378,0.00005331792,0.00002269841,0.0001901992,0.00006269185,0.00001037497,0.000245391],"genre_scores_gemma":[0.9932431,0.0001571553,0.006483834,0.00002872566,0.00002329116,0.00001656655,0.00001226364,0.00001725822,0.00001782805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002997335,"threshold_uncertainty_score":0.6261433,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2122406011","doi":"10.1002/cjce.5450810512","title":"Enhanced Production of Podophyllotoxin by Fed‐batch Cultivation of <i>Podophyllum hexandrum</i>","year":2003,"lang":"en","type":"article","venue":"The Canadian Journal of Chemical Engineering","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"","keywords":"Podophyllum; Podophyllotoxin; Biomass (ecology); Bioreactor; Fed-batch culture; Nutrient; Chemistry; Dry weight; Productivity; Botany; Food science; Pulp and paper industry; Biology; Fermentation; Agronomy; Engineering","retraction":null,"screen_n_in":null,"score":{"opus":0.005122103192067119,"gpt":0.1761207764035814,"spread":0.1709986732115143,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667856,0.00009318439,0.0001670127,0.00003942381,0.00002322369,0.000006521357,0.0001360202,0.00008798156,0.000005563484],"category_scores_gemma":[0.0003196238,0.00007174545,0.00008392674,0.00009154428,0.00005983125,0.0000071089,0.00000758193,0.0001133711,1.873681e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003045798,"about_ca_system_score_gemma":0.0001747225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001511699,"about_ca_topic_score_gemma":0.00004622303,"domain_scores_codex":[0.9993688,0.00002807908,0.0002588368,0.00008751155,0.0001083911,0.0001483954],"domain_scores_gemma":[0.9994498,0.00001818468,0.0001844412,0.0001251937,0.0001137363,0.0001085659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002213386,0.00001500665,0.0000613524,0.00002173873,0.00003618448,5.34219e-7,0.00003691455,0.000272949,0.9988469,0.00002589795,0.0003032356,0.0003571506],"study_design_scores_gemma":[0.0001368241,0.00006230862,0.00005716251,0.00004548685,0.0000144672,0.00003232309,0.00001465634,0.00001822472,0.9983943,0.00001628908,0.001131339,0.00007659815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998481,0.0003487159,0.000735281,0.0001099548,0.000138011,0.00005906956,0.00001467924,0.000001283539,0.0001119961],"genre_scores_gemma":[0.9995092,0.00001449721,0.000330934,0.00001467362,0.00008285556,0.000001232426,0.000005791077,0.00001054608,0.00003027934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028182,"threshold_uncertainty_score":0.2925695,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1969991719","doi":"10.1139/v99-220","title":"A short synthesis of both enantiomers of enterolactone","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false},"ca_institutions":"","funders":"","keywords":"Enterolactone; Chemistry; Lignan; Enantiomer; Enantioselective synthesis; Yield (engineering); Stereochemistry; Total synthesis; Organic chemistry; Catalysis","retraction":null,"screen_n_in":null,"score":{"opus":0.006341740238414649,"gpt":0.1950846336452656,"spread":0.1887428934068509,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936168,0.0001144963,0.0002736061,0.00004346838,0.00002621572,0.000007185012,0.0002466185,0.0001397711,0.0003587019],"category_scores_gemma":[0.00007002974,0.0001024289,0.0001882327,0.00006170595,0.0001529845,0.000005666582,0.000006965419,0.00008650552,6.869811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002127404,"about_ca_system_score_gemma":0.0004693772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003566436,"about_ca_topic_score_gemma":0.000327352,"domain_scores_codex":[0.999199,0.00002582656,0.0003488766,0.0001140051,0.0001165626,0.000195738],"domain_scores_gemma":[0.999256,0.00002053694,0.000181392,0.0001888964,0.00008335193,0.0002698813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007780862,0.00003421238,0.005809709,0.00005413319,0.0001265575,0.0000238674,0.00002478164,0.000007274848,0.9819388,3.234005e-7,0.0005513754,0.01135116],"study_design_scores_gemma":[0.0001248418,0.0000509033,0.004639761,0.0001018272,0.00003822264,0.0001948107,0.00006166218,0.000001644004,0.9882702,0.000003196533,0.006416475,0.00009646099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955207,0.0004918581,0.00001750668,0.00005635334,0.00003150331,0.00002579879,0.0001410851,7.453589e-7,0.003714491],"genre_scores_gemma":[0.9993469,0.0002149512,0.0001037457,0.00002055879,0.00009221369,8.538481e-7,0.000007498435,0.00001088042,0.0002024298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01125469,"threshold_uncertainty_score":0.4176928,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2733855591","doi":"10.1039/c7ra01476g","title":"Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects","year":2017,"lang":"en","type":"article","venue":"RSC Advances","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"National Institute for Nanotechnology; Alberta Hospital Edmonton","funders":"Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Bioassay; Isolation (microbiology); Botany; Biology; Traditional medicine; Horticulture; Chemistry; Microbiology; Medicine; Ecology","retraction":null,"screen_n_in":null,"score":{"opus":0.01148189240133719,"gpt":0.2492365389085903,"spread":0.2377546465072531,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429992,0.0001417837,0.0002135449,0.00001724172,0.0001672692,0.0000218363,0.0002510809,0.0001056532,0.000006303919],"category_scores_gemma":[0.0001168447,0.00008444361,0.00007953155,0.00002472588,0.0002855815,0.00001717127,0.0001064807,0.00004248524,8.074088e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000260417,"about_ca_system_score_gemma":0.00002375336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001472982,"about_ca_topic_score_gemma":0.0002172303,"domain_scores_codex":[0.9993054,0.00006783258,0.0001754691,0.0002396886,0.00008120299,0.0001304516],"domain_scores_gemma":[0.9990699,0.00009848565,0.0002962553,0.0004560764,0.00004855959,0.00003075018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000576471,0.00004248067,0.01485764,0.00003059703,0.00005794745,6.69063e-7,0.00006297897,0.000003730579,0.9770181,0.00003001222,0.00008555034,0.007752705],"study_design_scores_gemma":[0.0002929736,0.00009406255,0.04714438,0.00007922801,0.00002106296,0.000002234178,0.00006308289,0.00004959588,0.9479735,0.0002299949,0.003937606,0.0001122422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993399,0.004060692,0.001493045,0.0001834599,0.0001641691,0.0001504955,0.0001895917,0.000004900907,0.0003546189],"genre_scores_gemma":[0.997037,0.00220677,0.0005379204,0.00003010319,0.0001070103,0.000005867753,0.00003447986,0.000009167356,0.00003166584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03228674,"threshold_uncertainty_score":0.3443511,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2108182487","doi":"","title":"Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells.","year":2012,"lang":"en","type":"article","venue":"PubMed","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"Etoposide; Multiple drug resistance; Topoisomerase; Pharmacology; Podophyllotoxin; Cytotoxic T cell; Biology; Cancer research; Chemistry; Drug resistance; Biochemistry; Chemotherapy; In vitro; Stereochemistry; Microbiology","retraction":null,"screen_n_in":null,"score":{"opus":0.02421929302911909,"gpt":0.2502936411330611,"spread":0.226074348103942,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004152909,0.0003085698,0.0002867747,0.00007135163,0.0001935641,0.00003930551,0.0002426044,0.000178551,0.000008439586],"category_scores_gemma":[0.0001074649,0.0002705305,0.0001409036,0.0001397641,0.00009281435,0.00001750414,0.0001870846,0.0001279786,0.000006976596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001163752,"about_ca_system_score_gemma":0.0000325992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000304665,"about_ca_topic_score_gemma":0.000500257,"domain_scores_codex":[0.9981504,0.0001195382,0.0002254999,0.0004988719,0.0002064252,0.0007992464],"domain_scores_gemma":[0.9990047,0.0000559913,0.0001332139,0.0003674288,0.00007559064,0.0003630455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002271851,0.000317603,0.001413279,0.00002266476,0.0001479214,0.000001684721,0.0002103299,0.000007503807,0.9846962,0.00003052119,0.0008954208,0.0120297],"study_design_scores_gemma":[0.0004604683,0.00005632698,0.1845721,0.00001192334,0.00002799786,0.000001385381,0.00007853905,0.000002349288,0.7800161,0.000003209124,0.03443748,0.0003321419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956785,0.0002537825,0.0002821873,0.0002223593,0.0002858503,0.001457652,0.0004540145,0.0000275697,0.001338077],"genre_scores_gemma":[0.9946752,0.00003441238,0.0004329145,0.0009699157,0.0004918759,0.002865772,0.00007109148,0.00004410629,0.0004147063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2046801,"threshold_uncertainty_score":0.9999747,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1998002088","doi":"10.1016/j.indcrop.2014.10.055","title":"Aerial parts of Callitris species as a rich source of deoxypodophyllotoxin","year":2014,"lang":"en","type":"article","venue":"Industrial Crops and Products","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; Ligue Contre le Cancer","keywords":"Podophyllotoxin; Context (archaeology); Lignan; Podophyllum; Botany; Biology; Chemistry; Stereochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.02622350969875259,"gpt":0.221055408360661,"spread":0.1948318986619084,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004078515,0.0001448169,0.0002887769,0.00003511487,0.00005006323,0.00001585446,0.000122759,0.0002252153,0.00001931722],"category_scores_gemma":[0.0006309494,0.0001184343,0.00005167456,0.00009580241,0.0001969282,0.00000463738,0.00008674132,0.00009067762,0.00000152594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000037516,"about_ca_system_score_gemma":0.0000939353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002353054,"about_ca_topic_score_gemma":0.00001766967,"domain_scores_codex":[0.9989495,0.0001448613,0.0002634378,0.0003160898,0.0001426729,0.0001834632],"domain_scores_gemma":[0.9993296,0.00004094099,0.000193877,0.0002734529,0.00009877432,0.00006338907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004366843,0.00008686703,0.003394825,0.00002818819,0.00004599634,6.465448e-7,0.00005468936,0.000004257782,0.985235,0.0001160846,0.001341762,0.009255041],"study_design_scores_gemma":[0.0005594641,0.0004854354,0.00234781,0.00002223386,0.00002583017,0.000009382451,0.00003135325,0.000002039818,0.8776332,0.00003579191,0.1187186,0.0001287784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979815,0.0002033466,0.00003939585,0.0002302578,0.0002163216,0.0001846205,0.00004964233,0.00000512929,0.001089821],"genre_scores_gemma":[0.9979455,0.00008263456,0.0001226297,0.00002715162,0.001195549,0.000004223099,0.00002510467,0.00001155559,0.0005856263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1173769,"threshold_uncertainty_score":0.482961,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2079747871","doi":"10.1007/s13659-015-0057-3","title":"Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides","year":2015,"lang":"en","type":"article","venue":"Natural Products and Bioprospecting","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Chemistry; Cytotoxicity; Etoposide; Triazole; Moiety; MTT assay; Stereochemistry; Click chemistry; Cisplatin; Glycoside; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry; Biology; Chemotherapy","retraction":null,"screen_n_in":null,"score":{"opus":0.01887533131393762,"gpt":0.2440404843307641,"spread":0.2251651530168265,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004274361,0.0001872773,0.0002647475,0.00004282626,0.0000990662,0.00004115139,0.00008830074,0.000118577,0.00000135014],"category_scores_gemma":[0.0005699053,0.0001395695,0.00003767902,0.000119393,0.0001822331,0.00001930611,0.0001390606,0.0001274882,5.448699e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001340616,"about_ca_system_score_gemma":0.00004375267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001364958,"about_ca_topic_score_gemma":0.00003113457,"domain_scores_codex":[0.998918,0.00003974857,0.0001637202,0.0004888552,0.000157875,0.0002318117],"domain_scores_gemma":[0.9993874,0.00003843789,0.0001499445,0.0002067186,0.0001360197,0.00008140878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188898,0.00005107247,0.008666723,0.00006090699,0.00004325055,0.000002097593,0.00004112988,3.553051e-7,0.9698617,0.00005123184,0.00005807507,0.02094457],"study_design_scores_gemma":[0.0002618893,0.0001383123,0.02169887,0.00003806323,0.0000286685,0.00005119215,0.00009855394,0.00004994911,0.9769153,0.000063717,0.0004503671,0.0002051126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959349,0.003001694,0.000009994216,0.0004151608,0.0001656884,0.0002003406,0.00002627859,0.00001608542,0.0002298362],"genre_scores_gemma":[0.9982721,0.0002826262,0.0009489869,0.00002805489,0.0003171388,0.000006342602,0.00000401646,0.00001405904,0.0001266439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02073946,"threshold_uncertainty_score":0.569148,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2034982346","doi":"10.1016/j.cep.2009.07.011","title":"Radio frequency-assisted extraction of podophyllotoxin: Prototyping of packed bed extraction reactors and experimental observations","year":2009,"lang":"en","type":"article","venue":"Chemical Engineering and Processing - Process Intensification","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph; University of Saskatchewan","funders":"","keywords":"Extraction (chemistry); Solvent; Packed bed; Chromatography; Volumetric flow rate; Materials science; Analytical Chemistry (journal); Chemistry; Mechanics","retraction":null,"screen_n_in":null,"score":{"opus":0.02159144551433284,"gpt":0.2665285022806673,"spread":0.2449370567663345,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135678,0.0001427889,0.0001817325,0.00005584884,0.00004546642,0.00001875211,0.00005913581,0.0001579534,8.076367e-7],"category_scores_gemma":[0.000178811,0.0001372896,0.00003220957,0.0001263922,0.00006700189,0.00003914757,0.000009088361,0.0001000268,5.064918e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001582671,"about_ca_system_score_gemma":0.00003564642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006410141,"about_ca_topic_score_gemma":1.97269e-7,"domain_scores_codex":[0.9992251,0.00001174997,0.0002772813,0.0002671962,0.0001008047,0.0001178199],"domain_scores_gemma":[0.9994248,0.00001957724,0.0002105763,0.0001121658,0.0001809762,0.00005192099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008452906,0.0001030378,0.0002604046,0.0001985285,0.00001347887,2.269319e-7,0.0001612092,0.000008068278,0.9901477,0.00002867884,0.000002770682,0.008991423],"study_design_scores_gemma":[0.0001927492,0.00009696383,0.01014668,0.0001817482,0.00002122581,0.00003881456,0.0001609515,0.001897828,0.9870442,0.00004178629,0.00003117113,0.0001458992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965758,0.001122292,0.001957375,0.00007276887,0.00002539421,0.0001857436,0.000006821854,0.00002690392,0.00002688027],"genre_scores_gemma":[0.9962279,0.00006485557,0.003531593,0.00001259589,0.0000504191,0.00002807402,0.00006853027,0.00001218457,0.00000391205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009886276,"threshold_uncertainty_score":0.5598507,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2109240928","doi":"10.1177/2040206614566580","title":"Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor","year":2015,"lang":"en","type":"article","venue":"Antiviral chemistry & chemotherapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Lignan; Reverse transcriptase; Reverse-transcriptase inhibitor; Nucleoside Reverse Transcriptase Inhibitor; Enzyme; Human immunodeficiency virus (HIV); Biology; Nucleoside; Mechanism of action; In vitro; EC50; Drug; Virology; Pharmacology; Chemistry; Biochemistry; Stereochemistry; Viral disease; Antiretroviral therapy; Sida; Viral load; RNA","retraction":null,"screen_n_in":null,"score":{"opus":0.00906468489302717,"gpt":0.2314458601651324,"spread":0.2223811752721052,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003116948,0.0003054856,0.00033637,0.00003849205,0.00006027542,0.00003263799,0.0003123374,0.0002757346,0.00002594706],"category_scores_gemma":[0.00005933638,0.0002945876,0.0002249777,0.0001742191,0.0001759945,0.00002135411,0.00004322208,0.0001208824,0.000024662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002918068,"about_ca_system_score_gemma":0.0001482369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005104993,"about_ca_topic_score_gemma":0.000003554297,"domain_scores_codex":[0.9983819,0.00004242952,0.0004350999,0.0005471469,0.0002602104,0.0003332132],"domain_scores_gemma":[0.9988774,0.00001120635,0.0002724892,0.000551522,0.000129757,0.0001575985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004283997,0.0003158577,0.001048509,0.00006519509,0.00008942397,0.000008549747,0.000204329,0.000001738564,0.9909567,0.000002676603,0.004906285,0.001972369],"study_design_scores_gemma":[0.001264059,0.0001431667,0.0003769816,0.00005048084,0.00003423289,0.0000266306,0.0002747361,0.00004274193,0.9817103,0.00004059989,0.01569565,0.000340432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961377,0.0002262214,0.0003026719,0.0003244974,0.00008807171,0.0001967688,0.0001547113,0.00002610723,0.002543264],"genre_scores_gemma":[0.996927,0.0002628633,0.0002222895,0.0002410846,0.0003157413,0.00002041305,0.0001921157,0.00004368952,0.001774855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01078936,"threshold_uncertainty_score":0.9999506,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2189448670","doi":"10.1016/j.bmc.2015.09.039","title":"Ring substitution influences oxidative cyclisation and reactive metabolite formation of nordihydroguaiaretic acid analogues","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Nordihydroguaiaretic acid; Catechol; Quinone; Stereochemistry; Electrophilic substitution; Metabolite; Lignan; Intramolecular force; Polyphenol; Phenols; Electrophile; Antioxidant; Organic chemistry; Lipoxygenase; Biochemistry; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.02282069247342259,"gpt":0.2444707461782563,"spread":0.2216500537048338,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359285,0.0001571352,0.0002091326,0.00002954904,0.00005164988,0.00001240297,0.0001086547,0.0001574101,0.000005530657],"category_scores_gemma":[0.0003099086,0.0001331682,0.00003883881,0.0001051175,0.0002195505,0.00003097434,0.0000559639,0.0000881789,0.000001670892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003592218,"about_ca_system_score_gemma":0.0001048688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005007786,"about_ca_topic_score_gemma":0.0000104415,"domain_scores_codex":[0.9990711,0.00005133541,0.0002433723,0.0002540162,0.0002203387,0.0001598051],"domain_scores_gemma":[0.9993194,0.00001683825,0.0002312505,0.0001718243,0.0001407336,0.0001199572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009104118,0.00003288029,0.001828778,0.00005606246,0.00003968594,0.000001714088,0.0002626187,0.000001249146,0.9967253,0.00001758619,0.00002183983,0.0009212879],"study_design_scores_gemma":[0.0003920329,0.00008183318,0.006121059,0.00005359384,0.00007382969,0.00005772011,0.001052052,0.00007631363,0.9914662,0.00004558173,0.0004363725,0.000143385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960568,0.001616496,0.001486198,0.00006003599,0.00004645336,0.00009231972,0.00004797091,0.00001256386,0.0005811951],"genre_scores_gemma":[0.9990996,0.0002381857,0.0001874035,0.00002851724,0.0001639607,0.000006962098,0.0002530483,0.000007877159,0.00001442192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00525903,"threshold_uncertainty_score":0.5430441,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}