{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":818,"total_is_capped":false,"direct_labels_cover":1,"predictions_cover":818,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"cde18f9d463e","filters":{"topic":"Protein Degradation and Inhibitors"}},"results":[{"id":"W2041535798","doi":"10.1038/nature09504","title":"Selective inhibition of BET bromodomains","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4296,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Public Health Service; Cancer Research UK; Wellcome Trust","keywords":"Bromodomain; BRD4; Epigenetics; Chromatin; BET inhibitor; Small molecule; Histone; Fusion protein; Chemistry; Binding site; Computational biology; Acetylation; Biology; Cell biology; Cancer research; Biochemistry; Gene","authors":[{"name":"P. Filippakopoulos","is_ca":false},{"name":"Jun Qi","is_ca":false},{"name":"S. Picaud","is_ca":false},{"name":"Y. Shen","is_ca":false},{"name":"William Smith","is_ca":false},{"name":"O. Fedorov","is_ca":false},{"name":"Elizabeth M. Morse","is_ca":false},{"name":"T. Keates","is_ca":false},{"name":"Tyler Hickman","is_ca":false},{"name":"I. Felletar","is_ca":false},{"name":"Martin Philpott","is_ca":false},{"name":"Shonagh Munro","is_ca":false},{"name":"Michael R. McKeown","is_ca":false},{"name":"Yuchuan Wang","is_ca":false},{"name":"Amanda L. Christie","is_ca":false},{"name":"Nathan West","is_ca":false},{"name":"Michael J. Cameron","is_ca":false},{"name":"Brian E. Schwartz","is_ca":false},{"name":"Tom D. Heightman","is_ca":false},{"name":"Nicholas La Thangue","is_ca":false},{"name":"Christopher A. French","is_ca":false},{"name":"Olaf Wiest","is_ca":false},{"name":"Andrew L. Kung","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"James E. Bradner","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00277973780960531,"gpt":0.2342449400341446,"spread":0.2314652022245393,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178786,0.0003768419,0.000341981,0.0002583399,0.0001841872,0.0003370391,0.0003160076,0.000274214,0.001706315],"category_scores_gemma":[0.000152176,0.0001534453,0.0002209031,0.0002058289,0.0001868435,0.0001803811,0.0001662375,0.0005738441,0.0004081651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004906127,"about_ca_system_score_gemma":0.0002033816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004411611,"about_ca_topic_score_gemma":0.001110836,"domain_scores_codex":[0.9998493,0.00001547565,0.00001071002,0.00002642957,0.00004618683,0.00005181325],"domain_scores_gemma":[0.999933,0.00001932172,0.00001414542,0.00001037015,0.000007528754,0.00001557963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004832085,0.00008878364,0.0001058161,0.00007862502,0.00001979074,0.00005117921,0.00001248561,0.0002273152,0.9914929,0.001075973,0.0003701341,0.005993871],"study_design_scores_gemma":[0.00003848765,0.0001338347,0.0005135671,0.000002943366,0.0000106586,0.0001340924,0.000004605329,0.0007865851,0.9929974,0.00008730662,0.005286862,0.000003615495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648622,0.009587024,0.01089655,0.0004388493,0.0002594491,0.0001210199,0.0009367209,0.0003968241,0.01250136],"genre_scores_gemma":[0.9842044,0.003501349,0.003464427,0.0001271318,0.00003126787,0.00006471579,0.0006029269,0.00004702113,0.007956692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706315,"threshold_uncertainty_score":0.005708158,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2123647733","doi":"10.1016/j.cell.2012.02.013","title":"Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1752,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada Research Chairs; Ontario Institute for Cancer Research; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Acetylation; Biology; BRD4; Histone; Computational biology; Genetics; Structural similarity; BET inhibitor; Epigenetics; Biochemistry; DNA; Gene","authors":[{"name":"P. Filippakopoulos","is_ca":false},{"name":"S. Picaud","is_ca":true},{"name":"Maria Mangos","is_ca":true},{"name":"Tracy Keates","is_ca":true},{"name":"Jean‐Philippe Lambert","is_ca":true},{"name":"Dalia Baršytė-Lovejoy","is_ca":true},{"name":"I. Felletar","is_ca":true},{"name":"Rudolf Volkmer","is_ca":false},{"name":"Susanne Müller","is_ca":false},{"name":"Tony Pawson","is_ca":true},{"name":"Anne‐Claude Gingras","is_ca":true},{"name":"C.H. Arrowsmith","is_ca":true},{"name":"Stefan Knapp","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01339970949480928,"gpt":0.2479835714959281,"spread":0.2345838620011188,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735996,0.0002557361,0.0002170604,0.000186965,0.0001544511,0.0001775505,0.0002386441,0.0001415158,0.0006506472],"category_scores_gemma":[0.0001690778,0.0001213035,0.0003002368,0.0002020755,0.0001270755,0.0001196335,0.0001767226,0.000357225,0.0001782351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429179,"about_ca_system_score_gemma":0.0002537852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009214929,"about_ca_topic_score_gemma":0.001903463,"domain_scores_codex":[0.9999213,0.0000126257,0.000004603064,0.00001528342,0.00003304331,0.00001313987],"domain_scores_gemma":[0.9999402,0.00001066997,0.00001250925,0.000007431479,0.00001105592,0.00001809676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001575347,0.00006012129,0.001351807,0.00006524443,0.00002407551,0.0001117515,0.00002390636,0.0006491812,0.9926867,0.0001866538,0.0001737808,0.004509293],"study_design_scores_gemma":[0.00005152964,0.0002780305,0.02236251,0.000007011778,0.00006183251,0.0006925411,0.00004838104,0.007627374,0.962418,0.0001911559,0.006247128,0.00001462978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916732,0.001609699,0.004943252,0.0001351027,0.00001394325,0.00002281037,0.0005743051,0.00005436801,0.0009733774],"genre_scores_gemma":[0.9848275,0.00124117,0.01002854,0.00008068855,0.000007087883,0.00001731831,0.002821309,0.00001885252,0.0009576791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009214929,"threshold_uncertainty_score":0.002488077,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2003872705","doi":"10.1038/nrd4286","title":"Targeting bromodomains: epigenetic readers of lysine acetylation","year":2014,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1245,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Bromodomain; Acetylation; BRD4; Epigenetics; BET inhibitor; Chromatin; Drug discovery; Lysine; Computational biology; Transcriptional regulation; Biology; Regulator; Histone; Chemistry; Cell biology; Biochemistry; Transcription factor; Amino acid; Gene","authors":[{"name":"P. Filippakopoulos","is_ca":false},{"name":"Stefan Knapp","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01540294611039873,"gpt":0.3141765041191744,"spread":0.2987735580087757,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007333646,0.0008688846,0.001224529,0.001121402,0.0001881807,0.0009329599,0.001049526,0.0008916364,0.001969863],"category_scores_gemma":[0.0004927248,0.0003665046,0.0003674175,0.001118274,0.0005965147,0.001031567,0.0006704911,0.00187658,0.001622603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005718382,"about_ca_system_score_gemma":0.0004114245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004034842,"about_ca_topic_score_gemma":0.001355413,"domain_scores_codex":[0.9998174,0.00002255966,0.00001534387,0.00002756434,0.00008345774,0.00003365184],"domain_scores_gemma":[0.9998288,0.00007184058,0.00003277385,0.000008815848,0.00003762574,0.00002009069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000139334,0.00005962216,0.0002590375,0.005925124,0.0001192394,0.0003312737,0.00004246557,0.0006454724,0.01784626,0.00811139,0.02615164,0.9403691],"study_design_scores_gemma":[0.00004613483,0.00008685604,0.0005445115,0.0005532127,0.0001030863,0.001287289,0.00002231843,0.000232268,0.00805271,0.002769722,0.986279,0.00002298328],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005770927,0.9948213,0.001548454,0.0003988949,0.0003288088,0.00001044324,0.00003665576,0.00004411197,0.002234189],"genre_scores_gemma":[0.004583563,0.9912528,0.0008940067,0.0004654651,0.0002086176,0.00001485418,0.00008298497,0.000005880844,0.002491723],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001969863,"threshold_uncertainty_score":0.00658989,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2982554531","doi":"10.1038/s41573-019-0047-y","title":"Targeted protein degradation: expanding the toolbox","year":2019,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":938,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Wellcome Trust","keywords":"Drug discovery; Ubiquitin; Protein degradation; Computational biology; Proteasome; Toolbox; Proteolysis; Ubiquitin ligase; Chemical biology; Drug; Drug development; Bioinformatics; Computer science; Biology; Pharmacology; Cell biology; Biochemistry; Enzyme","authors":[{"name":"Matthieu Schapira","is_ca":true},{"name":"Matthew F. Calabrese","is_ca":false},{"name":"Alex N. Bullock","is_ca":false},{"name":"Craig M. Crews","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02643913160446375,"gpt":0.3262636766066986,"spread":0.2998245450022348,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001661202,0.001839611,0.002604948,0.00326416,0.0003671985,0.002378448,0.002019398,0.002923612,0.004230981],"category_scores_gemma":[0.001449967,0.0005008863,0.0007318988,0.003072062,0.001558876,0.003099563,0.001636845,0.00500172,0.003857215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001640699,"about_ca_system_score_gemma":0.001576119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044838,"about_ca_topic_score_gemma":0.002386945,"domain_scores_codex":[0.9994529,0.0000854134,0.00005528838,0.00008790462,0.0002547593,0.0000637967],"domain_scores_gemma":[0.9988856,0.00052597,0.0001176907,0.00004454087,0.0002534132,0.0001729373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001685095,0.00008930032,0.0001002916,0.009202613,0.00008821694,0.0001659106,0.0000276041,0.0005758151,0.002234961,0.007331963,0.08643275,0.8935819],"study_design_scores_gemma":[0.00004328969,0.00008160196,0.0002816477,0.001290116,0.00006806898,0.0006775704,0.00002250297,0.0002003622,0.000392875,0.003519865,0.9934024,0.00001969798],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003848739,0.9980197,0.0003119767,0.0005379233,0.0004045245,0.000003229487,0.00001479564,0.00001771105,0.0006516695],"genre_scores_gemma":[0.000365893,0.9975677,0.000291155,0.0007096797,0.0004391977,0.000006325061,0.00003407863,0.000002972514,0.0005829183],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004230981,"threshold_uncertainty_score":0.01415402,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2171613528","doi":"10.1038/nature13393","title":"Targeting transcription regulation in cancer with a covalent CDK7 inhibitor","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":900,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute","keywords":"Cyclin-dependent kinase 7; Cyclin-dependent kinase; Kinase; Transcription factor; Transcription (linguistics); Cancer research; Biology; Chemistry; Cell biology; Biochemistry; Cell; Cell cycle; Protein kinase A; Cyclin-dependent kinase 2; Gene","authors":[{"name":"Nicholas Kwiatkowski","is_ca":false},{"name":"Tinghu Zhang","is_ca":false},{"name":"Peter B. Rahl","is_ca":false},{"name":"Brian J. Abraham","is_ca":false},{"name":"Jessica Reddy","is_ca":false},{"name":"Scott B. Ficarro","is_ca":false},{"name":"Anahita Dastur","is_ca":false},{"name":"Arnaud Amzallag","is_ca":false},{"name":"Sridhar Ramaswamy","is_ca":false},{"name":"Bethany Tesar","is_ca":false},{"name":"Catherine E. Jenkins","is_ca":true},{"name":"Nancy M. Hannett","is_ca":false},{"name":"Douglas W. McMillin","is_ca":false},{"name":"Takaomi Sanda","is_ca":false},{"name":"Taebo Sim","is_ca":false},{"name":"Nam Doo Kim","is_ca":false},{"name":"Thomas Look","is_ca":false},{"name":"Constantine S. Mitsiades","is_ca":false},{"name":"Andrew P. Weng","is_ca":true},{"name":"Jennifer R. Brown","is_ca":false},{"name":"Cyril H. Benes","is_ca":false},{"name":"Jarrod A. Marto","is_ca":false},{"name":"Richard A. Young","is_ca":false},{"name":"Nathanael S. Gray","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004797204971728208,"gpt":0.2364676590853878,"spread":0.2316704541136596,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003397395,0.0003381776,0.0002160796,0.0002800096,0.0002944887,0.0005472226,0.0005289055,0.0002982992,0.001345398],"category_scores_gemma":[0.000235572,0.0001937122,0.000239421,0.0001925733,0.0003494463,0.0003281225,0.0003003496,0.0007125608,0.0003929233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008956899,"about_ca_system_score_gemma":0.0004851035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008384,"about_ca_topic_score_gemma":0.00254303,"domain_scores_codex":[0.9998249,0.00002488115,0.00001202364,0.000033598,0.00005614406,0.00004842538],"domain_scores_gemma":[0.9999119,0.00001780547,0.000023958,0.00001735513,0.00001254332,0.00001644291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003410091,0.0001296193,0.0006437272,0.0001715666,0.0000454988,0.0002226155,0.00003202306,0.001309552,0.9689395,0.008999369,0.000976192,0.01818941],"study_design_scores_gemma":[0.00002466885,0.0001759493,0.0003763635,0.00000477004,0.00001731704,0.0002369571,0.000009531917,0.001400368,0.9883052,0.0002982434,0.009143676,0.000006931345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.904677,0.02406816,0.04563975,0.001987372,0.0004403643,0.0002160252,0.0005943345,0.000787187,0.02158979],"genre_scores_gemma":[0.9853397,0.004232307,0.00514013,0.0001397733,0.00003433593,0.00005040787,0.0001673263,0.00004360466,0.004852292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001345398,"threshold_uncertainty_score":0.006498754,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2226721679","doi":"10.1038/nature16508","title":"Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":629,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"Congressionally Directed Medical Research Programs; National Human Genome Research Institute; National Cancer Institute; Dana-Farber/Harvard Cancer Center; Ludwig Center at Harvard; National Institutes of Health; Cancer Research UK; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense; Princess Margaret Cancer Foundation; Cancer Prevention and Research Institute of Texas; Susan G. Komen for the Cure","keywords":"Bromodomain; BRD4; Triple-negative breast cancer; BET inhibitor; Chromatin; Cancer research; Breast cancer; Cancer; Epigenetics; Biology; Gene; Genetics","authors":[{"name":"Shaokun Shu","is_ca":false},{"name":"Charles Y. Lin","is_ca":false},{"name":"Housheng Hansen He","is_ca":true},{"name":"Robert M. Witwicki","is_ca":false},{"name":"Doris P. Tabassum","is_ca":false},{"name":"Justin M. Roberts","is_ca":false},{"name":"Michalina Janiszewska","is_ca":false},{"name":"Sung Jin Huh","is_ca":false},{"name":"Yi Liang","is_ca":true},{"name":"Jeremy Ryan","is_ca":false},{"name":"Ernest Doherty","is_ca":false},{"name":"Hisham Mohammed","is_ca":false},{"name":"Hao Guo","is_ca":false},{"name":"Daniel G. Stover","is_ca":false},{"name":"Muhammad B. Ekram","is_ca":false},{"name":"Guillermo Peluffo","is_ca":false},{"name":"Jonathan D. Brown","is_ca":false},{"name":"Clive S. D’Santos","is_ca":false},{"name":"Ian E. Krop","is_ca":false},{"name":"Deborah Dillon","is_ca":false},{"name":"Michael R. McKeown","is_ca":false},{"name":"Christopher J. Ott","is_ca":false},{"name":"Jun Qi","is_ca":false},{"name":"Min Ni","is_ca":false},{"name":"Prakash K. Rao","is_ca":false},{"name":"Melissa Duarte","is_ca":false},{"name":"Shwu-Yuan Wu","is_ca":false},{"name":"Cheng-Ming Chiang","is_ca":false},{"name":"Lars Anders","is_ca":false},{"name":"Richard A. Young","is_ca":false},{"name":"Eric P. Winer","is_ca":false},{"name":"Antony Letai","is_ca":false},{"name":"William T. Barry","is_ca":false},{"name":"Jason S. Carroll","is_ca":false},{"name":"Henry W. Long","is_ca":false},{"name":"Myles Brown","is_ca":false},{"name":"X. Shirley Liu","is_ca":false},{"name":"Clifford A. Meyer","is_ca":false},{"name":"James E. Bradner","is_ca":false},{"name":"Kornélia Polyák","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003928327806201479,"gpt":0.251001048709911,"spread":0.2470727209037095,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002722878,0.0001272622,0.0003331034,0.0002509914,0.0001457594,0.000350298,0.0001291666,0.0003017543,0.001953019],"category_scores_gemma":[0.000306044,0.00011746,0.000166614,0.0001647453,0.0001306426,0.0001472459,0.0001263393,0.0004834385,0.0002612969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427795,"about_ca_system_score_gemma":0.000141983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004203221,"about_ca_topic_score_gemma":0.0007553555,"domain_scores_codex":[0.9998652,0.00002091717,0.00001017531,0.00001592008,0.00004510016,0.00004284029],"domain_scores_gemma":[0.9998584,0.00004013055,0.00003025919,0.00001607527,0.00001561557,0.00003954868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003616589,0.000284559,0.008319691,0.00008302522,0.00005344677,0.0005838376,0.0000679453,0.0006941646,0.9553868,0.0006720487,0.00142644,0.02881148],"study_design_scores_gemma":[0.0004160143,0.006978415,0.1691556,0.00003313977,0.0001811966,0.01112729,0.000385365,0.005999965,0.7747443,0.001361711,0.02958088,0.00003622654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925261,0.003936279,0.0003135217,0.0003348622,0.0000343662,0.00001391757,0.0002150706,0.00003788496,0.002588035],"genre_scores_gemma":[0.9971124,0.0008261398,0.000122512,0.00008186548,0.000008422225,0.00001151209,0.000217771,0.00000555116,0.001613714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001953019,"threshold_uncertainty_score":0.006533444,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3102624934","doi":"10.1038/s41467-020-19532-z","title":"The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":574,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Institute of Genetics; Japan Science and Technology Agency; Japan Agency for Medical Research and Development; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; University of Dundee; Asahi Glass Foundation; Takeda Science Foundation","keywords":"Degron; Gene knockdown; Mutant; Cell biology; Yeast; Degradation (telecommunications); Saccharomyces cerevisiae; Function (biology); Phenotype; Protein degradation; Auxin; Chemistry; Biology; Gene; Biochemistry; Computer science; Ubiquitin ligase; Ubiquitin","authors":[{"name":"Aisha Yesbolatova","is_ca":false},{"name":"Yuichiro Saito","is_ca":false},{"name":"Naomi Kitamoto","is_ca":false},{"name":"Hatsune Makino‐Itou","is_ca":false},{"name":"Rieko Ajima","is_ca":false},{"name":"Risako Nakano","is_ca":false},{"name":"Hirofumi Nakaoka","is_ca":false},{"name":"Kosuke Fukui","is_ca":false},{"name":"Kanae Gamo","is_ca":false},{"name":"Yusuke Tominari","is_ca":false},{"name":"Haruki Takeuchi","is_ca":false},{"name":"Yumiko Saga","is_ca":false},{"name":"Ken‐ichiro Hayashi","is_ca":false},{"name":"Masato T. Kanemaki","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01217306286600655,"gpt":0.2527165831789991,"spread":0.2405435203129925,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00101398,0.001308552,0.0005167897,0.001669124,0.0007042892,0.0008901817,0.0008634639,0.0009381281,0.00348841],"category_scores_gemma":[0.0002258091,0.0008876091,0.0007814692,0.0005123646,0.000764059,0.0006084757,0.000746879,0.0014834,0.002147579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006643625,"about_ca_system_score_gemma":0.0005936784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008368746,"about_ca_topic_score_gemma":0.002419946,"domain_scores_codex":[0.999127,0.0001492768,0.0001223581,0.0002359487,0.0002641301,0.0001012702],"domain_scores_gemma":[0.9995478,0.00006768865,0.0001414506,0.0001003205,0.0000379358,0.0001048097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001596672,0.00003796258,0.0001346162,0.00008002377,0.00001063232,0.00008469744,0.00003319698,0.0001286532,0.9941745,0.001129501,0.0004528578,0.003573615],"study_design_scores_gemma":[0.00004899775,0.0001393552,0.000985425,0.00001203734,0.00001725256,0.0004045258,0.00001546159,0.001018377,0.9763997,0.00009143899,0.02085448,0.00001305626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5586985,0.007692135,0.3901319,0.001465606,0.000736131,0.001452281,0.01387112,0.0106344,0.01531794],"genre_scores_gemma":[0.698864,0.008067628,0.2284257,0.0005057814,0.0001293969,0.002258178,0.009580153,0.002247381,0.04992168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00348841,"threshold_uncertainty_score":0.01166993,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2237475663","doi":"10.1016/j.cell.2015.11.062","title":"Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":497,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute","keywords":"Biology; Breast cancer; Computational biology; Cancer; Small hairpin RNA; Point mutation; Gene; Genetics; Genomics; Genome-wide association study; Genome; Bioinformatics; Mutation; Single-nucleotide polymorphism; RNA; Genotype","authors":[{"name":"Richard Marcotte","is_ca":true},{"name":"Azin Sayad","is_ca":true},{"name":"Kevin R. Brown","is_ca":true},{"name":"Félix Sanchez-Garcia","is_ca":false},{"name":"Jüri Reimand","is_ca":true},{"name":"Maliha Haider","is_ca":true},{"name":"Carl Virtanen","is_ca":true},{"name":"James E. Bradner","is_ca":false},{"name":"Gary D. Bader","is_ca":true},{"name":"Gordon B. Mills","is_ca":false},{"name":"Dana Pe’er","is_ca":false},{"name":"Jason Moffat","is_ca":true},{"name":"Benjamin G. Neel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006695832529943527,"gpt":0.2053287445523454,"spread":0.1986329120224019,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012639,0.0001338316,0.0002427063,0.000809813,0.0001644212,0.0004695904,0.0001588742,0.0002473182,0.003737826],"category_scores_gemma":[0.0003362933,0.0001240596,0.0001493695,0.0006245589,0.0001959247,0.0001399495,0.0002167455,0.0002031928,0.0003904293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123878,"about_ca_system_score_gemma":0.0001388158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009035966,"about_ca_topic_score_gemma":0.001179944,"domain_scores_codex":[0.9998817,0.00001513147,0.00000610725,0.00003850037,0.00002867529,0.00002981696],"domain_scores_gemma":[0.9998097,0.00006486914,0.00006727387,0.00001707741,0.00001578373,0.00002548176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002525636,0.0001019139,0.3124212,0.0001906978,0.000325245,0.001600161,0.0003275403,0.002095619,0.6059003,0.005214989,0.001569133,0.06772748],"study_design_scores_gemma":[0.00003538613,0.0002813416,0.939058,0.00002730308,0.0003312742,0.004420378,0.0003765872,0.001987301,0.03846841,0.003996952,0.0109989,0.00001821243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936752,0.002226521,0.0004577583,0.0002807464,0.000004058981,0.000004380646,0.001510932,0.00003605242,0.001804295],"genre_scores_gemma":[0.9983662,0.0004725584,0.0001198418,0.00004222343,0.00000446719,0.000002813635,0.0004898541,0.000008321927,0.0004936447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003737826,"threshold_uncertainty_score":0.01250434,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2024469844","doi":"10.1073/pnas.1310658110","title":"RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":481,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust; GlaxoSmithKline; Pfizer","keywords":"Bromodomain; Selectivity; Chemistry; BET inhibitor; Biochemistry; Gene; Epigenetics","authors":[{"name":"S. Picaud","is_ca":false},{"name":"Christopher Wells","is_ca":false},{"name":"I. Felletar","is_ca":false},{"name":"Deborah H. Brotherton","is_ca":false},{"name":"Sarah Martin","is_ca":false},{"name":"P. Savitsky","is_ca":false},{"name":"Beatriz Díez-Dacal","is_ca":false},{"name":"Martin Philpott","is_ca":false},{"name":"C. Bountra","is_ca":false},{"name":"Hannah Lingard","is_ca":false},{"name":"O. Fedorov","is_ca":false},{"name":"Susanne Müller","is_ca":false},{"name":"Paul E. Brennan","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"P. Filippakopoulos","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02047971555116908,"gpt":0.2644422861358543,"spread":0.2439625705846852,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439566,0.000214051,0.0003058845,0.0001403746,0.0001081064,0.0002214362,0.000165201,0.000222533,0.001247444],"category_scores_gemma":[0.00007173476,0.00009011284,0.0001684679,0.00009628128,0.0001113386,0.0001193147,0.00009304215,0.0004626893,0.0003954389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379849,"about_ca_system_score_gemma":0.0001249081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002044003,"about_ca_topic_score_gemma":0.0005584927,"domain_scores_codex":[0.9999433,0.000009990942,0.000003998018,0.00001175032,0.00001649592,0.00001451299],"domain_scores_gemma":[0.9999651,0.00001215686,0.000006884311,0.000002789131,0.000003324479,0.000009732705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002387461,0.00006350593,0.0002116968,0.00007696041,0.000009369404,0.0000578909,0.000009267023,0.0002224578,0.9891701,0.0003157785,0.0002009533,0.009423247],"study_design_scores_gemma":[0.0001096833,0.0007667133,0.002101327,0.000005354829,0.00001532672,0.0008074821,0.000008647008,0.001152505,0.9865346,0.00006500688,0.008425764,0.000007726213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617749,0.01602076,0.0123437,0.0003073959,0.00009219697,0.0001567997,0.0005365438,0.000227252,0.008540495],"genre_scores_gemma":[0.9745481,0.006389678,0.009949123,0.0001638214,0.00002925716,0.00008835648,0.001271918,0.00002971619,0.007530012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247444,"threshold_uncertainty_score":0.0041731,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2000832682","doi":"10.1016/j.molcel.2007.06.027","title":"Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme","year":2007,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":441,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Université Laval; University of Toronto; Université de Sherbrooke; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Transcription (linguistics); Transcription factor; Computational biology; Interaction network; Cell biology; Genetics; Gene","authors":[{"name":"Celia Jerónimo","is_ca":true},{"name":"Diane Forget","is_ca":true},{"name":"Annie Bouchard","is_ca":true},{"name":"Qintong Li","is_ca":false},{"name":"Gordon Chua","is_ca":true},{"name":"Christian Poitras","is_ca":true},{"name":"Cynthia Thérien","is_ca":true},{"name":"Dominique Bergeron","is_ca":true},{"name":"Sylvie Bourassa","is_ca":true},{"name":"Jack Greenblatt","is_ca":true},{"name":"Benoı̂t Chabot","is_ca":true},{"name":"Guy G. Poirier","is_ca":true},{"name":"Timothy R. Hughes","is_ca":true},{"name":"Mathieu Blanchette","is_ca":true},{"name":"David H. Price","is_ca":false},{"name":"Benoit Coulombe","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009670997196912508,"gpt":0.2525091586157963,"spread":0.2428381614188838,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456965,0.0002531091,0.0003522167,0.0008308725,0.0003752759,0.0002985263,0.0001727976,0.0001542114,0.0007420459],"category_scores_gemma":[0.0003564687,0.0001414238,0.0004041668,0.0007082563,0.0001890309,0.0002317507,0.0001665174,0.000299853,0.0002664146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564097,"about_ca_system_score_gemma":0.0003955131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294968,"about_ca_topic_score_gemma":0.002736274,"domain_scores_codex":[0.9998873,0.00002031138,0.000008443498,0.00004120029,0.00002471404,0.00001796478],"domain_scores_gemma":[0.9996996,0.0001124972,0.00007506735,0.00004322529,0.00003349666,0.0000361899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008069074,0.00008793689,0.01413365,0.0002504982,0.0001255625,0.0003039866,0.00005861984,0.004719103,0.9557813,0.001676544,0.0004247604,0.02163112],"study_design_scores_gemma":[0.00006946556,0.0005521399,0.1684857,0.0000310898,0.0005739587,0.001862536,0.0001396353,0.1143507,0.6991726,0.005311162,0.009408075,0.00004306359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98773,0.0008712218,0.00945765,0.00004643581,0.000004264688,0.00001669756,0.001185867,0.0001215849,0.0005663031],"genre_scores_gemma":[0.9823335,0.0005280667,0.0117657,0.00002413274,0.000005537487,0.00002317695,0.004828691,0.00003350007,0.0004577238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294968,"threshold_uncertainty_score":0.002585948,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2027275928","doi":"10.1038/nchembio.1197","title":"Target validation using chemical probes","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":435,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"University of Toronto; University of Oxford; Harvard University; Pfizer","keywords":"Relevance (law); Chemical biology; Computer science; Computational biology; Interpretation (philosophy); Biochemical engineering; Data science; Biology; Engineering","authors":[{"name":"Mark E. Bunnage","is_ca":false},{"name":"Eugene L. Piatnitski Chekler","is_ca":false},{"name":"Lyn H. Jones","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007007253976963497,"gpt":0.2589165346044496,"spread":0.2519092806274861,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00392334,0.002185883,0.001162066,0.001264444,0.001214348,0.002147136,0.00114859,0.002414448,0.00396711],"category_scores_gemma":[0.003300634,0.001041537,0.001277785,0.0008741294,0.001394558,0.001562469,0.001552681,0.002965644,0.003371095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001841832,"about_ca_system_score_gemma":0.001623977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006555289,"about_ca_topic_score_gemma":0.001007468,"domain_scores_codex":[0.9960403,0.001060806,0.0002591341,0.0009789466,0.001168031,0.0004927902],"domain_scores_gemma":[0.9972302,0.0008192026,0.0004572172,0.0006886165,0.0006835848,0.0001211734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002044929,0.00005874289,0.0002688257,0.000196508,0.00003324505,0.0001064433,0.00005320696,0.0008119123,0.9862686,0.002336399,0.0004633437,0.009198268],"study_design_scores_gemma":[0.00001368727,0.000139098,0.0001577257,0.00001489251,0.000018238,0.00009833151,0.00001434227,0.00170341,0.992558,0.0002621658,0.005007366,0.00001275337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2840184,0.005763893,0.6636251,0.001658008,0.0006275222,0.00141358,0.001476179,0.003975905,0.03744138],"genre_scores_gemma":[0.7581748,0.006042713,0.1993704,0.001997678,0.0001156334,0.001979006,0.004110484,0.001264225,0.0269452],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00396711,"threshold_uncertainty_score":0.02074885,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2299417213","doi":"10.1158/1535-7163.mct-15-0843","title":"An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":432,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University College of the North","funders":"","keywords":"Cancer; In vivo; Combination therapy; Cancer cell; Pharmacology; Medicine; Computational biology; Cancer therapy; Drug; Cancer research; Cancer treatment; Biology; Internal medicine; Genetics","authors":[{"name":"Jennifer O’Neil","is_ca":false},{"name":"Yair Benita","is_ca":false},{"name":"Igor Feldman","is_ca":false},{"name":"Mélissa Chénard","is_ca":false},{"name":"Brian S. Roberts","is_ca":false},{"name":"Yaping Liu","is_ca":true},{"name":"Jing Li","is_ca":true},{"name":"Astrid M. Kral","is_ca":false},{"name":"Serguei Lejnine","is_ca":false},{"name":"Andrey Loboda","is_ca":false},{"name":"William T. Arthur","is_ca":false},{"name":"Răzvan Cristescu","is_ca":false},{"name":"Brian B. Haines","is_ca":false},{"name":"Christopher Winter","is_ca":false},{"name":"Theresa Zhang","is_ca":false},{"name":"Andrew Bloecher","is_ca":false},{"name":"Stuart D. Shumway","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03619010624958395,"gpt":0.3574481275927425,"spread":0.3212580213431586,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001064404,0.001205579,0.001747902,0.002192866,0.0005663945,0.0008022105,0.0005772832,0.0005585641,0.00380684],"category_scores_gemma":[0.0009556718,0.0005295426,0.0007219304,0.00163042,0.0002904728,0.0004827745,0.0007833496,0.0007176707,0.001510705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004904117,"about_ca_system_score_gemma":0.001137734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007998465,"about_ca_topic_score_gemma":0.003484995,"domain_scores_codex":[0.9988472,0.0002149498,0.00009549224,0.0001899228,0.000532389,0.0001199751],"domain_scores_gemma":[0.9994816,0.0001581579,0.00007141527,0.00007568276,0.0001671419,0.00004608736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004802151,0.0008848927,0.005966353,0.000489941,0.0002326595,0.0004867736,0.00007380571,0.004109488,0.9192886,0.0007221984,0.002507105,0.06475792],"study_design_scores_gemma":[0.0004710019,0.00927552,0.02256242,0.00008784595,0.001068479,0.002241788,0.0001634136,0.01567524,0.8930801,0.001154857,0.05411294,0.0001064359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8291257,0.02376136,0.08945656,0.001236025,0.0002243743,0.006026986,0.0232135,0.002379446,0.02457602],"genre_scores_gemma":[0.830593,0.01468683,0.1183888,0.0008734662,0.0001332076,0.003051492,0.01895631,0.0003159384,0.01300106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00380684,"threshold_uncertainty_score":0.01273513,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2299219969","doi":"10.1016/s2352-3026(15)00247-1","title":"Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study","year":2016,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":431,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre","funders":"Agence Nationale de la Recherche","keywords":"Medicine; Bromodomain; Internal medicine; Leukemia; Oncology","authors":[{"name":"Céline Berthon","is_ca":false},{"name":"Emmanuel Raffoux","is_ca":false},{"name":"Xavier Thomas","is_ca":false},{"name":"Norbert Vey","is_ca":false},{"name":"Carlos Gomez‐Roca","is_ca":false},{"name":"Karen Yee","is_ca":true},{"name":"David Taussig","is_ca":false},{"name":"Keyvan Rezaï","is_ca":false},{"name":"Christophe Roumier","is_ca":false},{"name":"Patrice Herait","is_ca":false},{"name":"Carmen Kahatt","is_ca":false},{"name":"Bruno Quesnel","is_ca":false},{"name":"Mauricette Michallet","is_ca":false},{"name":"Christian Récher","is_ca":false},{"name":"François Lokiec","is_ca":false},{"name":"Claude Preudhomme","is_ca":false},{"name":"Hervé Dombret","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01162699876201042,"gpt":0.2695873245110347,"spread":0.2579603257490243,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001073891,0.001172663,0.002122558,0.0003184164,0.0002498633,0.001069375,0.0007196711,0.0006839643,0.003123243],"category_scores_gemma":[0.0007167363,0.0003356519,0.001330373,0.00035046,0.0006325482,0.0006527306,0.0003327486,0.002428746,0.0006279189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009494102,"about_ca_system_score_gemma":0.000968034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021326,"about_ca_topic_score_gemma":0.002723695,"domain_scores_codex":[0.9997218,0.0001167821,0.00001602646,0.00003884092,0.00003302758,0.00007353363],"domain_scores_gemma":[0.9995531,0.0001026672,0.00008279167,0.00003686708,0.00002208891,0.0002024414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6754246,0.02521362,0.006932453,0.001903653,0.002744624,0.0002688764,0.0004302393,0.004133288,0.03792024,0.0006941698,0.004556573,0.2397776],"study_design_scores_gemma":[0.5850488,0.3723701,0.02898311,0.0001403132,0.001031721,0.0005606789,0.0001932679,0.001982612,0.003367344,0.0005956614,0.00566627,0.00006012106],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940888,0.003118577,0.0003777983,0.0003064436,0.0001045839,0.0004433442,0.0004454794,0.00007002897,0.001044977],"genre_scores_gemma":[0.9879329,0.004139465,0.0011611,0.0007793856,0.0001349956,0.0006927825,0.001798863,0.00002556345,0.003335082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003123243,"threshold_uncertainty_score":0.01044834,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1974631163","doi":"10.1016/j.febslet.2012.04.045","title":"The bromodomain interaction module","year":2012,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Genome Canada; Wellcome Trust; Novartis Foundation","keywords":"Bromodomain; Acetylation; Histone; Lysine; Computational biology; Proteome; Chemistry; Epigenetics; Translation (biology); Biochemistry; Biology; Cell biology; Gene; Amino acid; Messenger RNA","authors":[{"name":"P. Filippakopoulos","is_ca":false},{"name":"Stefan Knapp","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03125933788246484,"gpt":0.2989202822770627,"spread":0.2676609443945979,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002045219,0.0005138208,0.0005539659,0.0004470066,0.0001819522,0.0005739713,0.0006015546,0.0005167678,0.002564409],"category_scores_gemma":[0.0001634564,0.0001701727,0.0002173566,0.0004265521,0.0002969061,0.0004478045,0.0004580227,0.0006306463,0.003794191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003998835,"about_ca_system_score_gemma":0.0002454884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002783952,"about_ca_topic_score_gemma":0.0002551083,"domain_scores_codex":[0.9998952,0.00001248554,0.000007546319,0.00002455485,0.00004026732,0.00001992206],"domain_scores_gemma":[0.9999456,0.00001195532,0.00001714362,0.000004064706,0.000009982679,0.0000111653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003092957,0.00008814097,0.0006205619,0.006338846,0.0001005953,0.0006073642,0.00009111666,0.0006345272,0.2885967,0.01024817,0.01659642,0.6757682],"study_design_scores_gemma":[0.00002183124,0.0001427793,0.00170616,0.0001717594,0.00004055395,0.002522232,0.00002458169,0.0001446992,0.06805211,0.0008351965,0.9263208,0.00001718542],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01768062,0.9441854,0.006464379,0.0004553521,0.0005186906,0.00008271143,0.0005941732,0.0003171972,0.02970141],"genre_scores_gemma":[0.1651907,0.7686795,0.009344818,0.001450058,0.0004215562,0.0001484306,0.002150782,0.00006655462,0.05254751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002564409,"threshold_uncertainty_score":0.008578777,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2512442926","doi":"10.1038/nchembio.2166","title":"Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":372,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; Ministero dello Sviluppo Economico; Ontario Genomics Institute; Hope Funds for Cancer Research; Diamond Light Source; National Human Genome Research Institute; Wellcome Trust; National Institutes of Health; Ontario Genomics; Genome Canada; Ontario Ministry of Economic Development and Innovation; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Deutsche Forschungsgemeinschaft; Dana-Farber/Harvard Cancer Center; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Kinase; Enhancer; Cell biology; Biology; Transcription factor; Cyclin-dependent kinase; Processivity; Gene expression; Transcription (linguistics); Gene; Chemistry; Molecular biology; Genetics; Polymerase; Cell cycle","authors":[{"name":"Tinghu Zhang","is_ca":false},{"name":"Nicholas Kwiatkowski","is_ca":false},{"name":"Sarah E. Dixon-Clarke","is_ca":false},{"name":"Brian J. Abraham","is_ca":false},{"name":"Ann Katrin Greifenberg","is_ca":false},{"name":"Scott B. Ficarro","is_ca":false},{"name":"Jonathan M. Elkins","is_ca":false},{"name":"Yanke Liang","is_ca":false},{"name":"Nancy M. Hannett","is_ca":false},{"name":"Theresa Manz","is_ca":false},{"name":"Mingfeng Hao","is_ca":false},{"name":"Bartlomiej Bartkowiak","is_ca":false},{"name":"Arno L. Greenleaf","is_ca":false},{"name":"Jarrod A. Marto","is_ca":false},{"name":"Matthias Geyer","is_ca":false},{"name":"Alex N. Bullock","is_ca":false},{"name":"Richard A. Young","is_ca":false},{"name":"Nathanael S. Gray","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005339544952155734,"gpt":0.2519261609122563,"spread":0.2465866159601005,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003930424,0.0003946053,0.0002525667,0.0001820343,0.0002493278,0.0003337719,0.0004728179,0.0003366008,0.001782451],"category_scores_gemma":[0.0002373147,0.0001824513,0.0002638655,0.0001727541,0.0002701521,0.0002851425,0.0003055574,0.0008346774,0.0003934229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007015266,"about_ca_system_score_gemma":0.0003491323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007660979,"about_ca_topic_score_gemma":0.001722544,"domain_scores_codex":[0.9998473,0.00002249567,0.00001377512,0.00002911458,0.00004378402,0.00004349033],"domain_scores_gemma":[0.9998914,0.00001615946,0.0000317744,0.00001560614,0.00001971905,0.00002533677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002487707,0.0001293593,0.0002184721,0.0001271144,0.00003032206,0.0001747942,0.00003918189,0.00111224,0.9846082,0.003607655,0.0003754818,0.009328512],"study_design_scores_gemma":[0.00003234617,0.0001716141,0.0001903966,0.000004025667,0.00001363204,0.0001409707,0.000007233062,0.0008447956,0.9938783,0.0001091352,0.004601235,0.000006330171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475258,0.00405785,0.03685431,0.0004367395,0.0001704039,0.0002535736,0.0003382541,0.0003074445,0.0100556],"genre_scores_gemma":[0.9828812,0.001647453,0.008970802,0.0000978629,0.00001524182,0.00005733794,0.0002035538,0.00003908069,0.006087437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001782451,"threshold_uncertainty_score":0.005962908,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3095840616","doi":"10.1177/2472555220965528","title":"E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones","year":2020,"lang":"en","type":"review","venue":"SLAS DISCOVERY","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":369,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"FP7 Ideas: European Research Council; European Commission; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; McGill University","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Drug discovery; Computational biology; Cereblon; Protein degradation; Ubiquitin-Protein Ligases; Proteasome; Chemistry; Biology; Biochemistry; DNA","authors":[{"name":"Tasuku Ishida","is_ca":false},{"name":"Alessio Ciulli","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03057431257181093,"gpt":0.2985406958382705,"spread":0.2679663832664596,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028043,0.001158598,0.001816556,0.001982969,0.0002480895,0.00164917,0.001147167,0.00146558,0.003233084],"category_scores_gemma":[0.0010973,0.0004599789,0.000728143,0.00207057,0.0006613772,0.001845825,0.0008088486,0.002928807,0.002491391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001079779,"about_ca_system_score_gemma":0.001246304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032224,"about_ca_topic_score_gemma":0.00248375,"domain_scores_codex":[0.9997579,0.00003253598,0.00002944897,0.0000500285,0.00008395744,0.00004615822],"domain_scores_gemma":[0.9996605,0.0001432406,0.00004681651,0.00001423657,0.00009277408,0.0000424158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002934661,0.00007412447,0.0002322726,0.01481415,0.0001822727,0.0002549528,0.00003474111,0.0006200778,0.003657723,0.00722252,0.05044489,0.9221687],"study_design_scores_gemma":[0.00005115385,0.0001021428,0.0003427392,0.001757703,0.0001718325,0.0007867875,0.00002670601,0.0001582553,0.001425387,0.001803079,0.9933501,0.00002408014],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001299298,0.9984505,0.0002679719,0.0003085229,0.0001862809,0.000004947189,0.00003474602,0.00001571519,0.0006013194],"genre_scores_gemma":[0.001004551,0.9970018,0.0003968347,0.0004624724,0.0001397813,0.000009189765,0.00009931147,0.000003908016,0.00088215],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003233084,"threshold_uncertainty_score":0.01081574,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3138474425","doi":"10.1038/s41416-021-01321-0","title":"Achieving clinical success with BET inhibitors as anti-cancer agents","year":2021,"lang":"en","type":"review","venue":"British Journal of Cancer","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":354,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada","keywords":"Medicine; Cancer; Oncology; Bioinformatics; Internal medicine; Biology","authors":[{"name":"Tatiana Shorstova","is_ca":true},{"name":"William D. Foulkes","is_ca":true},{"name":"Michael Witcher","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04076842658982904,"gpt":0.4049207177462221,"spread":0.364152291156393,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000859048,0.000901223,0.001368595,0.001419617,0.0002762872,0.001180414,0.0009529005,0.00171027,0.004212406],"category_scores_gemma":[0.001024418,0.0003476551,0.0005673924,0.0009640097,0.0005560814,0.001263576,0.0006509781,0.003712859,0.003158202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008262497,"about_ca_system_score_gemma":0.0005820054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005741467,"about_ca_topic_score_gemma":0.001810769,"domain_scores_codex":[0.9997509,0.00004718751,0.00002893745,0.00004125065,0.00009783431,0.00003386763],"domain_scores_gemma":[0.9996495,0.000183018,0.00003748553,0.00001028507,0.00007950169,0.00004013732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002735869,0.0001424556,0.0001208295,0.007652866,0.0001070942,0.0003030677,0.00006074467,0.0006286905,0.003310245,0.009598777,0.04561863,0.932183],"study_design_scores_gemma":[0.00008162305,0.000206747,0.0004823853,0.001360441,0.00005744362,0.0007999613,0.00002177853,0.000120405,0.001040033,0.001923655,0.9938914,0.00001420826],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000353122,0.9958763,0.0002733088,0.0007230033,0.0003966714,0.00001033045,0.0000352133,0.00001906407,0.002312968],"genre_scores_gemma":[0.00233874,0.9934708,0.000462585,0.0008682464,0.0003197459,0.0000231849,0.00006902866,0.00000679688,0.002440873],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004212406,"threshold_uncertainty_score":0.01409191,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3173153622","doi":"10.1038/s41568-021-00367-9","title":"MYC protein interactors in gene transcription and cancer","year":2021,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":352,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Structural Genomics Consortium; Sunnybrook Hospital; University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Interactome; Transcription factor; Biology; Carcinogenesis; Epigenetics; Promoter; Computational biology; Gene; Cell biology; Transcription (linguistics); Cancer research; Genetics; Gene expression","authors":[{"name":"Corey Lourenco","is_ca":true},{"name":"Diana Resetca","is_ca":true},{"name":"Cornelia Redel","is_ca":true},{"name":"Peter Lin","is_ca":true},{"name":"Alannah S. MacDonald","is_ca":true},{"name":"Roberto Ciaccio","is_ca":false},{"name":"Tristan M. G. Kenney","is_ca":true},{"name":"Yong Wei","is_ca":true},{"name":"David W. Andrews","is_ca":true},{"name":"Maria Sunnerhagen","is_ca":false},{"name":"C.H. Arrowsmith","is_ca":true},{"name":"Brian Raught","is_ca":true},{"name":"Linda Z. Penn","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02906492708313017,"gpt":0.3708726183859068,"spread":0.3418076913027766,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007679423,0.00152424,0.001997105,0.001946894,0.0003636865,0.001359773,0.001519359,0.002036564,0.00484046],"category_scores_gemma":[0.0005276539,0.0005310117,0.0005573523,0.002874938,0.0009411774,0.001638854,0.001210641,0.003040398,0.004460435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001265541,"about_ca_system_score_gemma":0.0008636387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101888,"about_ca_topic_score_gemma":0.002235388,"domain_scores_codex":[0.9997584,0.00003456967,0.00002469914,0.00003637723,0.0001070501,0.00003898708],"domain_scores_gemma":[0.9996983,0.0001232967,0.00004682444,0.00001143484,0.0000738332,0.00004628033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002448143,0.00008062703,0.0001418273,0.01015586,0.00009141258,0.0002307881,0.00003353062,0.0006852685,0.003792858,0.01112459,0.1360031,0.8374153],"study_design_scores_gemma":[0.00003144785,0.00005813044,0.0005053147,0.00133162,0.00006141761,0.0007536253,0.00002140865,0.0001159397,0.0003773679,0.002961871,0.9937682,0.00001367229],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003032027,0.9988753,0.00007000692,0.0002310566,0.0002525635,0.00000168849,0.00001114714,0.000006087508,0.0005217406],"genre_scores_gemma":[0.0003020523,0.9983017,0.00006563256,0.0002268286,0.00029719,0.000004379748,0.00002808533,0.000001349064,0.0007726778],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00484046,"threshold_uncertainty_score":0.01619297,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2016988770","doi":"10.1073/pnas.1216363109","title":"Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":348,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Bromodomain; BET inhibitor; BRD4; Epigenetics; Transcription factor; Biology; Cancer research; Gene knockdown; Gene; Ectopic expression; Cell biology; Molecular biology; Genetics","authors":[{"name":"William W. Lockwood","is_ca":false},{"name":"Kreshnik Zejnullahu","is_ca":false},{"name":"James E. Bradner","is_ca":false},{"name":"Harold Varmus","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02537418135966299,"gpt":0.2853383197730813,"spread":0.2599641384134184,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002270739,0.0003578518,0.0004047847,0.0003542242,0.0001874734,0.0003768695,0.0001840706,0.0003539555,0.001543194],"category_scores_gemma":[0.0002299064,0.0002200243,0.000306748,0.0003378052,0.0001681895,0.000165235,0.0002025981,0.0006023943,0.0004934218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003382499,"about_ca_system_score_gemma":0.0002115158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002572549,"about_ca_topic_score_gemma":0.002308313,"domain_scores_codex":[0.999605,0.00007142546,0.00005595341,0.00006798806,0.0001269477,0.00007264758],"domain_scores_gemma":[0.9997606,0.00007743399,0.00004010823,0.0000394561,0.00004073269,0.00004161092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073231,0.00007316009,0.0004186746,0.00002315158,0.00001065808,0.00003189736,0.00002405898,0.0001191186,0.9982783,0.00004630795,0.00005190935,0.0008153701],"study_design_scores_gemma":[0.00001611786,0.0009483756,0.01002068,0.000004145134,0.000017197,0.0002225325,0.00005430398,0.001292072,0.9860659,0.00003083604,0.001322211,0.000005680745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933769,0.001929106,0.001638639,0.0001075452,0.00003520522,0.00005650576,0.001085654,0.0000775141,0.001693009],"genre_scores_gemma":[0.9901648,0.001598179,0.001506121,0.0001054768,0.0000101132,0.00009812268,0.002729661,0.0000227778,0.003764693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002572549,"threshold_uncertainty_score":0.005162477,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4220990424","doi":"10.1038/s41573-022-00409-3","title":"The emerging role of mass spectrometry-based proteomics in drug discovery","year":2022,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":347,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph","funders":"","keywords":"Drug discovery; Proteomics; Mass spectrometry; Computational biology; Drug; Chemistry; Data science; Pharmacology; Computer science; Medicine; Chromatography; Biology; Biochemistry","authors":[{"name":"Felix Meissner","is_ca":false},{"name":"Jennifer Geddes‐McAlister","is_ca":true},{"name":"Matthias Mann","is_ca":true},{"name":"Marcus Bantscheff","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01024856041706307,"gpt":0.2894495030299467,"spread":0.2792009426128836,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002616102,0.001639812,0.002744889,0.00268978,0.0002907765,0.002068831,0.001879227,0.002570207,0.003127421],"category_scores_gemma":[0.002015945,0.000472123,0.0008088967,0.00379305,0.001590174,0.003216255,0.001306086,0.00406997,0.002771383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001283839,"about_ca_system_score_gemma":0.001410839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398023,"about_ca_topic_score_gemma":0.002311605,"domain_scores_codex":[0.9992884,0.0001366734,0.00004863569,0.00009769015,0.0003660969,0.00006254232],"domain_scores_gemma":[0.9983428,0.0009692038,0.0001487778,0.00005985952,0.0003393609,0.0001401318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001988461,0.0001108802,0.0001705751,0.01282414,0.0002644301,0.0002229221,0.00003446611,0.000975,0.005471244,0.01006203,0.04690835,0.9227569],"study_design_scores_gemma":[0.0000731348,0.0001755812,0.0007554141,0.001811776,0.0001996112,0.001113501,0.00004078503,0.0006065606,0.001430053,0.008323087,0.9854203,0.00005026011],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007235156,0.9976351,0.00077988,0.0004703803,0.0003114583,0.000003988896,0.00001730141,0.0000200104,0.0006895514],"genre_scores_gemma":[0.0005113342,0.9974202,0.0006985305,0.0005778909,0.0003606536,0.000006234993,0.00003003499,0.000003193555,0.0003920291],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003127421,"threshold_uncertainty_score":0.01383549,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4386446579","doi":"10.1038/s41392-023-01589-z","title":"Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials","year":2023,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":344,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Chengdu University; Jiangxi University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine; National Natural Science Foundation of China","keywords":"Drug discovery; Computational biology; Drug development; Biology; Drug; Bioinformatics; Pharmacology","authors":[{"name":"Xin Xie","is_ca":true},{"name":"Tingting Yu","is_ca":false},{"name":"Xiang Li","is_ca":false},{"name":"Nan Zhang","is_ca":false},{"name":"Leonard J. Foster","is_ca":true},{"name":"Cheng Peng","is_ca":false},{"name":"Wei Huang","is_ca":false},{"name":"Gu He","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1058780823456495,"gpt":0.4042721095420451,"spread":0.2983940271963956,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008861194,0.0009563727,0.001311434,0.00232112,0.0002370939,0.001217465,0.0008882678,0.001101141,0.003809078],"category_scores_gemma":[0.0009365553,0.0003200971,0.0006205725,0.002208611,0.0005160861,0.00151367,0.0008440458,0.002197521,0.002033752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007083667,"about_ca_system_score_gemma":0.001030786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005801207,"about_ca_topic_score_gemma":0.001219233,"domain_scores_codex":[0.9997765,0.00003940826,0.00002732903,0.00004376096,0.00008208202,0.00003090418],"domain_scores_gemma":[0.999531,0.0002483521,0.00005408266,0.00001279819,0.0001006216,0.00005311993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001640819,0.0001502666,0.0001630914,0.0206426,0.0001042902,0.000253192,0.00007462284,0.0006985451,0.004611093,0.006724208,0.03063625,0.9357777],"study_design_scores_gemma":[0.00003834646,0.0002190389,0.0004183212,0.002432279,0.0001328755,0.0008745861,0.0000454233,0.0001549007,0.001202637,0.002236069,0.9922253,0.00002016885],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000187623,0.9978604,0.0002911919,0.0003318701,0.0001891325,0.000007700984,0.00002129862,0.00001300784,0.001097849],"genre_scores_gemma":[0.0007074209,0.9980322,0.000279659,0.0003265117,0.0001333369,0.000009280593,0.00003331486,0.000002388439,0.000475963],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003809078,"threshold_uncertainty_score":0.01274258,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2747084483","doi":"10.1038/nm.4379","title":"Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation","year":2017,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Bromodomain; BRD4; BET inhibitor; Cancer research; Ubiquitin ligase; Prostate cancer; Biology; mTORC1; Signal transducing adaptor protein; Protein kinase B; Chemistry; Cell biology; Cancer; Ubiquitin; Epigenetics; Biochemistry; Genetics; Gene; Signal transduction","authors":[{"name":"Pingzhao Zhang","is_ca":false},{"name":"Dejie Wang","is_ca":false},{"name":"Yu Zhao","is_ca":false},{"name":"Shancheng Ren","is_ca":false},{"name":"Kun Gao","is_ca":false},{"name":"Zhenqing Ye","is_ca":false},{"name":"Shangqian Wang","is_ca":false},{"name":"Chun-Wu Pan","is_ca":false},{"name":"Yasheng Zhu","is_ca":false},{"name":"Yuqian Yan","is_ca":false},{"name":"Yinhui Yang","is_ca":false},{"name":"Di Wu","is_ca":false},{"name":"Yundong He","is_ca":false},{"name":"Jun Zhang","is_ca":false},{"name":"Daru Lu","is_ca":false},{"name":"Xiuping Liu","is_ca":false},{"name":"Long Yu","is_ca":false},{"name":"Shimin Zhao","is_ca":false},{"name":"Yao Li","is_ca":false},{"name":"Dong Lin","is_ca":true},{"name":"Yuzhuo Wang","is_ca":true},{"name":"Liguo Wang","is_ca":false},{"name":"Yu Chen","is_ca":false},{"name":"Yinghao Sun","is_ca":false},{"name":"Chenji Wang","is_ca":false},{"name":"Haojie Huang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005170535343120824,"gpt":0.2670491265184531,"spread":0.2618785911753323,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414091,0.0002398547,0.0002763868,0.0003155713,0.000202551,0.0005837927,0.0002132199,0.0002034159,0.002008981],"category_scores_gemma":[0.0001720404,0.0002183253,0.0002563865,0.0002322442,0.0001901792,0.0001870531,0.0002331505,0.0006708529,0.0003556684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000427009,"about_ca_system_score_gemma":0.0001994834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000335887,"about_ca_topic_score_gemma":0.0007459974,"domain_scores_codex":[0.9998521,0.00001735362,0.00001006483,0.00002529082,0.00004355455,0.00005181339],"domain_scores_gemma":[0.9999194,0.00001230809,0.00002335412,0.00001100912,0.000007989431,0.00002585383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005511742,0.0001145221,0.003934019,0.00005052158,0.00003555973,0.0003990783,0.00001791546,0.0003843952,0.9849024,0.0008787686,0.0005742472,0.008157452],"study_design_scores_gemma":[0.0001270283,0.0008114512,0.06763863,0.00001201792,0.00007448607,0.005798362,0.00006779822,0.004942858,0.9095398,0.0005657942,0.01040409,0.0000176226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948758,0.001451107,0.0008615722,0.0002475873,0.00002798548,0.00001679853,0.0004471549,0.000114804,0.00195717],"genre_scores_gemma":[0.9982968,0.0003146246,0.0002560789,0.00003661844,0.000006161807,0.00000842817,0.0002516733,0.00001248302,0.0008171138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002008981,"threshold_uncertainty_score":0.006720662,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3008322752","doi":"10.1126/sciadv.aay5064","title":"PHOTACs enable optical control of protein degradation","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":298,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institutes of Health; National Cancer Institute; New York University; York University; Howard Hughes Medical Institute","keywords":"Degradation (telecommunications); Protein degradation; Modular design; Computer science; Control (management); Biophysics; Chemistry; Cell biology; Biology; Biochemistry; Telecommunications; Artificial intelligence","authors":[{"name":"Martin Reynders","is_ca":false},{"name":"Bryan S. Matsuura","is_ca":false},{"name":"Marleen Bérouti","is_ca":false},{"name":"Daniele Simoneschi","is_ca":false},{"name":"Antonio Marzio","is_ca":false},{"name":"Michele Pagano","is_ca":false},{"name":"Dirk Trauner","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009361328203190755,"gpt":0.2499912143661777,"spread":0.240629886162987,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741137,0.0002893592,0.0001478344,0.0001401788,0.0001472199,0.0003366206,0.0002916513,0.0003758058,0.001513466],"category_scores_gemma":[0.000153166,0.0001546207,0.0001943299,0.0001421659,0.0003016781,0.0003121113,0.0003282239,0.0006321543,0.0003094105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000408593,"about_ca_system_score_gemma":0.0002055548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000294092,"about_ca_topic_score_gemma":0.0003942831,"domain_scores_codex":[0.9998573,0.00001307506,0.00000777398,0.00004710733,0.00004947707,0.00002526892],"domain_scores_gemma":[0.9999007,0.00001983656,0.00003807437,0.00001397201,0.00001167573,0.00001574399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004342065,0.000009310023,0.00003990199,0.00002873685,0.000003071517,0.00001825035,0.000009619791,0.0001263282,0.9948742,0.001351114,0.0001258338,0.003370217],"study_design_scores_gemma":[0.000007033816,0.00004712462,0.0001560225,0.000001573515,0.00000216465,0.00006383567,0.000003577639,0.0006935424,0.9957132,0.0001084544,0.003200359,0.000003179885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8711758,0.003202294,0.1089163,0.0005600354,0.0001994213,0.0001216129,0.0006682517,0.00131467,0.01384163],"genre_scores_gemma":[0.9675072,0.001193354,0.02560431,0.0001821826,0.00002369296,0.00008272268,0.0001972826,0.00006693435,0.005142406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513466,"threshold_uncertainty_score":0.005062997,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2135676046","doi":"10.1158/1078-0432.ccr-12-3066","title":"Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma","year":2013,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":295,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Bromodomain; Glioblastoma; Biology; Cancer research; Computational biology; Medicine; Genetics; Epigenetics; Gene","authors":[{"name":"Zhixiang Cheng","is_ca":false},{"name":"Yuanying Gong","is_ca":false},{"name":"Yufang Ma","is_ca":false},{"name":"Kaihua Lu","is_ca":false},{"name":"Xiang Lu","is_ca":false},{"name":"Larry A. Pierce","is_ca":false},{"name":"Reid C. Thompson","is_ca":false},{"name":"Susanne Müller","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Jialiang Wang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0788149943909722,"gpt":0.4284188748675226,"spread":0.3496038804765503,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155156,0.0003177983,0.0003020637,0.0002418456,0.000128176,0.0001953002,0.0001387098,0.0001420135,0.0005378564],"category_scores_gemma":[0.00007184957,0.00007745999,0.0001691659,0.0001555273,0.0001424096,0.0001245479,0.0001205224,0.0003225884,0.000126908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000293868,"about_ca_system_score_gemma":0.0001688524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004719124,"about_ca_topic_score_gemma":0.001384553,"domain_scores_codex":[0.9999316,0.000006737629,0.000006004207,0.00001296137,0.00002305123,0.00001975612],"domain_scores_gemma":[0.9999591,0.000006460768,0.00001433481,0.000004613258,0.000004815859,0.00001077501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009926221,0.00004834637,0.0003583932,0.00003794522,0.000008740527,0.00003774761,0.000009280954,0.0001526429,0.9969217,0.00006239813,0.00005077259,0.002212738],"study_design_scores_gemma":[0.0000559601,0.0008497065,0.007349022,0.000007646428,0.0000517053,0.0005178245,0.00002582124,0.001165963,0.9868418,0.00005072873,0.003079519,0.000004219241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971602,0.001217621,0.0006988312,0.00003738601,0.00001068972,0.00002708359,0.0001704386,0.00003105481,0.0006466149],"genre_scores_gemma":[0.9973134,0.001068768,0.0006611828,0.0000276203,0.000004328105,0.0000230028,0.0004071204,0.000007684061,0.0004868884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005378564,"threshold_uncertainty_score":0.002132177,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1995827055","doi":"10.1021/ja412434f","title":"Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains","year":2014,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; European Commission; British Heart Foundation; Wellcome Trust; Wellcome","keywords":"Bromodomain; Chemistry; BRD4; Small molecule; Selectivity; Lead compound; Binding site; Combinatorial chemistry; Stereochemistry; Biochemistry; In vitro; DNA","authors":[{"name":"Duncan A. Hay","is_ca":false},{"name":"Oleg Fedorov","is_ca":false},{"name":"Sarah Martin","is_ca":false},{"name":"Dean C. Singleton","is_ca":false},{"name":"C. Tallant","is_ca":false},{"name":"Christopher Wells","is_ca":false},{"name":"S. Picaud","is_ca":false},{"name":"Martin Philpott","is_ca":false},{"name":"Octovia Monteiro","is_ca":false},{"name":"Catherine Rogers","is_ca":false},{"name":"Stuart J. Conway","is_ca":false},{"name":"Timothy P. C. Rooney","is_ca":false},{"name":"Anthony Tumber","is_ca":false},{"name":"Clarence Yapp","is_ca":false},{"name":"P. Filippakopoulos","is_ca":false},{"name":"Mark E. Bunnage","is_ca":false},{"name":"Susanne Müller","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Christopher J. Schofield","is_ca":false},{"name":"Paul E. Brennan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006335565921639335,"gpt":0.2271048963405571,"spread":0.2207693304189177,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074435,0.0004941525,0.0004647366,0.0003029864,0.0001494504,0.0003376614,0.0005955257,0.0002869011,0.001320667],"category_scores_gemma":[0.0001557553,0.0002024237,0.0002963648,0.0003030661,0.0001799213,0.0001994404,0.0002797102,0.0005940953,0.0005075052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000595491,"about_ca_system_score_gemma":0.0003078475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007787194,"about_ca_topic_score_gemma":0.002332907,"domain_scores_codex":[0.9998927,0.00001749268,0.000007511362,0.0000167413,0.00003549512,0.00003000224],"domain_scores_gemma":[0.9999599,0.000005645789,0.0000095588,0.000003540935,0.000009429074,0.00001194139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003424599,0.0001782248,0.0003598099,0.0002984194,0.00004443827,0.0002328266,0.00004180909,0.002768765,0.9793729,0.0006403556,0.0004505496,0.01526949],"study_design_scores_gemma":[0.0005471387,0.002630973,0.002320333,0.00003161366,0.0001213962,0.0007044387,0.00006803258,0.004974907,0.9687434,0.0002392763,0.01957964,0.00003885002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581608,0.0137073,0.01987914,0.0003341921,0.00006455008,0.0004334698,0.001070808,0.0003274755,0.006022231],"genre_scores_gemma":[0.9704183,0.00869179,0.01410467,0.0001694162,0.00002153779,0.0002415507,0.001407325,0.00003112066,0.004914276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320667,"threshold_uncertainty_score":0.004418075,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2028561673","doi":"10.1021/jm300346w","title":"Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canada Foundation for Innovation; Wellcome Trust; Cancer Research UK; Takeda Pharmaceuticals North America; Abbott Laboratories; Wellcome; GlaxoSmithKline; Canadian Institutes of Health Research; National Institute for Health and Care Research; Novartis; Pfizer","keywords":"Bromodomain; Druggability; Chemistry; Computational biology; Lysine; Drug discovery; Epigenetics; Amino acid; Biochemistry; Gene; Biology","authors":[{"name":"Lewis R. Vidler","is_ca":false},{"name":"Nathan Brown","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Swen Hoelder","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01226193625074663,"gpt":0.2757646594124243,"spread":0.2635027231616777,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003695608,0.0001924428,0.0003300964,0.001306033,0.0002069167,0.0003600233,0.0001764309,0.0002493473,0.0007885438],"category_scores_gemma":[0.0008025282,0.00009175953,0.0003945841,0.0006868708,0.0001713712,0.0002913573,0.0001639778,0.0002787622,0.0001879786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002341698,"about_ca_system_score_gemma":0.0001721282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006693938,"about_ca_topic_score_gemma":0.0008195849,"domain_scores_codex":[0.9998091,0.00004034434,0.00001530157,0.0000305787,0.00007929969,0.00002552389],"domain_scores_gemma":[0.9993735,0.0002519015,0.0001554927,0.00005170529,0.0001099852,0.00005753582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001267357,0.0002304134,0.04455705,0.0002957475,0.00009989036,0.0002151911,0.0001417157,0.01739162,0.8859635,0.001252856,0.0003883782,0.0481962],"study_design_scores_gemma":[0.00008435895,0.00193765,0.178259,0.00003008755,0.0002560247,0.001172985,0.0002257326,0.2722383,0.5378187,0.002348245,0.005549223,0.00007975391],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901833,0.0003740495,0.007357059,0.00003246377,0.00000447881,0.0000337782,0.0006938473,0.00014283,0.001178265],"genre_scores_gemma":[0.987447,0.000216192,0.01080954,0.00001480132,0.00000239039,0.00002334706,0.001178162,0.00001819985,0.0002903408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306033,"threshold_uncertainty_score":0.002637923,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2616008841","doi":"10.1126/scitranslmed.aah5084","title":"BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure","year":2017,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BIO (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Bromodomain; Transactivation; BRD4; Pressure overload; Heart failure; Induced pluripotent stem cell; Coactivator; Cancer research; Epigenetics; Biology; Medicine; Bioinformatics; Transcription factor; Internal medicine; Gene; Genetics; Cardiac hypertrophy","authors":[{"name":"Qiming Duan","is_ca":false},{"name":"Sarah McMahon","is_ca":false},{"name":"Priti Anand","is_ca":false},{"name":"Hirsh Shah","is_ca":false},{"name":"Hazel T. Salunga","is_ca":false},{"name":"Yu Huang","is_ca":false},{"name":"Rongli Zhang","is_ca":false},{"name":"Aarathi Sahadevan","is_ca":false},{"name":"Madeleine E. Lemieux","is_ca":true},{"name":"Jonathan D. Brown","is_ca":false},{"name":"Deepak Srivastava","is_ca":false},{"name":"James E. Bradner","is_ca":false},{"name":"Timothy A. McKinsey","is_ca":false},{"name":"Saptarsi M. Haldar","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01111003851060657,"gpt":0.2657487783509653,"spread":0.2546387398403588,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951545,0.000271337,0.0002933555,0.0001939286,0.0001188252,0.0001709377,0.0001894846,0.0002185788,0.00094698],"category_scores_gemma":[0.00009731852,0.0000969508,0.000191734,0.0000995233,0.0002162195,0.0001462482,0.0001425461,0.0005292395,0.0002133476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332437,"about_ca_system_score_gemma":0.0001807856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002041734,"about_ca_topic_score_gemma":0.000450375,"domain_scores_codex":[0.9999275,0.00001207069,0.000006519791,0.00001239995,0.00001899003,0.00002244538],"domain_scores_gemma":[0.999956,0.000007013016,0.00001262416,0.000004113941,0.000004190356,0.00001604518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006890988,0.0001773182,0.0002308873,0.00008962216,0.00001733552,0.00003278772,0.00001626763,0.0002220966,0.9931933,0.0001750986,0.0001422062,0.005013949],"study_design_scores_gemma":[0.0006382717,0.005165366,0.0184242,0.00003287397,0.0001308138,0.0005040179,0.00009399145,0.00344049,0.9595805,0.0004703155,0.01149824,0.00002080537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992348,0.003502561,0.001772063,0.0001717536,0.00006968256,0.00003361303,0.0002743613,0.0001196106,0.001708495],"genre_scores_gemma":[0.9952726,0.001861053,0.0007940462,0.0001267648,0.00002077326,0.00003801103,0.0003984219,0.00001811689,0.001470259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00094698,"threshold_uncertainty_score":0.003167927,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2152855058","doi":"10.1093/nar/gkn061","title":"LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":251,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"P-TEFb; snRNP; Molecular biology; RNA polymerase II; Biology; RNA; Chemistry; Gene expression; Biochemistry; RNA splicing; Gene; Promoter","authors":[{"name":"Brian J. Krueger","is_ca":false},{"name":"Cármen Jerónimo","is_ca":false},{"name":"Bibhuti Bhusan Roy","is_ca":false},{"name":"A. Bouchard","is_ca":false},{"name":"Charlotte Barrandon","is_ca":false},{"name":"S. A. Byers","is_ca":false},{"name":"C. E. Searcey","is_ca":false},{"name":"H. John Cooper","is_ca":false},{"name":"Olivier Bensaude","is_ca":false},{"name":"E. A. Cohen","is_ca":false},{"name":"Benoit Coulombe","is_ca":false},{"name":"David H. Price","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05123672583281211,"gpt":0.295641692870347,"spread":0.2444049670375349,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035505,0.0003947268,0.0002684867,0.0002782102,0.000293581,0.0003975027,0.0002580126,0.0002738812,0.001612681],"category_scores_gemma":[0.000181001,0.0001784269,0.000336463,0.0001750292,0.0002788903,0.0002074752,0.0003153753,0.0003781972,0.001334899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003610215,"about_ca_system_score_gemma":0.0002072941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005632299,"about_ca_topic_score_gemma":0.001006583,"domain_scores_codex":[0.9998491,0.00001557829,0.00001157596,0.0000450935,0.000054375,0.00002433925],"domain_scores_gemma":[0.9998192,0.0000235046,0.00004955471,0.00002001446,0.00003543336,0.00005232558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006273866,0.000005794611,0.0004155205,0.0000434312,0.0000134669,0.000135065,0.00001042234,0.00002809491,0.9973601,0.00007701408,0.0000586321,0.001789737],"study_design_scores_gemma":[0.000008714583,0.0001156869,0.011604,0.00001606024,0.00002795952,0.0009347319,0.00004879948,0.0007781915,0.9795628,0.0001184184,0.006777148,0.000007628161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831195,0.005042392,0.007604946,0.000165214,0.00006300226,0.00002854009,0.0008968507,0.0002449329,0.002834501],"genre_scores_gemma":[0.9819753,0.00147022,0.00537614,0.0001748879,0.00003955773,0.00004832554,0.004167293,0.0001095821,0.006638739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001612681,"threshold_uncertainty_score":0.005394995,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1965466808","doi":"10.1016/j.molcel.2005.05.012","title":"Binding of pRB to the PHD Protein RBP2 Promotes Cellular Differentiation","year":2005,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Biology; E2F; Transcription factor; Cell biology; Retinoblastoma protein; Chromatin; Pioneer factor; Forkhead Transcription Factors; Chromatin immunoprecipitation; Promoter; Genetics; Chromatin remodeling; Gene; Gene expression; Cell cycle","authors":[{"name":"Elizaveta V. Benevolenskaya","is_ca":false},{"name":"Heather L. Murray","is_ca":false},{"name":"Philip E. Branton","is_ca":true},{"name":"Richard A. Young","is_ca":false},{"name":"William G. Kaelin","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007227782632790802,"gpt":0.2050898648381059,"spread":0.1978620822053151,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951351,0.0003150796,0.0003449056,0.0002804432,0.0003237539,0.0005932943,0.0002286806,0.0002549972,0.002661653],"category_scores_gemma":[0.0001968856,0.0002895137,0.0002904404,0.000188155,0.0002736877,0.0002141898,0.0003126486,0.0009870633,0.001152608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006446556,"about_ca_system_score_gemma":0.0003478912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354208,"about_ca_topic_score_gemma":0.002712953,"domain_scores_codex":[0.999786,0.00002545104,0.000012413,0.00003791445,0.00006284713,0.00007549687],"domain_scores_gemma":[0.9998139,0.00004181036,0.00002559602,0.00002980786,0.0000195561,0.00006936479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977738,0.00002537716,0.0001009802,0.00003558572,0.000004572681,0.0000397318,0.000009354764,0.00005627609,0.9978712,0.0001721313,0.0001749515,0.001312124],"study_design_scores_gemma":[0.00001902051,0.00007036412,0.001954237,0.000002193106,0.000004178328,0.0001000268,0.00001450692,0.0004706596,0.99246,0.00004122717,0.004861099,0.000002503657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666078,0.0123427,0.009541931,0.000607277,0.000195833,0.00005007616,0.0007289459,0.0005322899,0.009393075],"genre_scores_gemma":[0.9826147,0.001918049,0.002866818,0.00009802914,0.00003918498,0.00002600669,0.000823094,0.00007847515,0.01153562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002661653,"threshold_uncertainty_score":0.008904099,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3136508589","doi":"10.1016/j.cell.2021.03.026","title":"BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Resverlogix (Canada)","funders":"National Health and Medical Research Council; Deutsche Forschungsgemeinschaft; Australian Research Council; QIMR Berghofer Medical Research Institute","keywords":"Biology; Inflammation; Bromodomain; Cytokine storm; Cardiac dysfunction; Immunology; Myocarditis; Cytokine; HMGB1; Viral Myocarditis; Virus; Internal medicine; Coronavirus disease 2019 (COVID-19); Heart failure; Gene; Medicine; Infectious disease (medical specialty); Disease; Acetylation; Genetics","authors":[{"name":"Richard J. Mills","is_ca":false},{"name":"Sean J. Humphrey","is_ca":false},{"name":"Patrick R.J. Fortuna","is_ca":false},{"name":"Mary Lor","is_ca":false},{"name":"Simon R. Foster","is_ca":false},{"name":"Gregory A. Quaife-Ryan","is_ca":false},{"name":"Rebecca L. Johnston","is_ca":false},{"name":"Troy Dumenil","is_ca":false},{"name":"Cameron Bishop","is_ca":false},{"name":"Rajeev Rudraraju","is_ca":false},{"name":"Daniel J. Rawle","is_ca":false},{"name":"Thuy T. T. Le","is_ca":false},{"name":"Wei Zhao","is_ca":false},{"name":"Leo Lee","is_ca":false},{"name":"Charley Mackenzie-Kludas","is_ca":false},{"name":"Neda R. Mehdiabadi","is_ca":false},{"name":"Christopher Halliday","is_ca":true},{"name":"Dean Gilham","is_ca":true},{"name":"Li Fu","is_ca":true},{"name":"Stephen J. Nicholls","is_ca":false},{"name":"Jan O. Johansson","is_ca":false},{"name":"Michael Sweeney","is_ca":false},{"name":"Norman C.W. Wong","is_ca":true},{"name":"Ewelina Kulikowski","is_ca":true},{"name":"Kamil A. Sokolowski","is_ca":false},{"name":"Brian Wan-Chi Tse","is_ca":false},{"name":"Lynn Devilée","is_ca":false},{"name":"Holly K. Voges","is_ca":false},{"name":"Liam Reynolds","is_ca":false},{"name":"Sophie Krumeich","is_ca":false},{"name":"Ellen Mathieson","is_ca":false},{"name":"Dad Abu-Bonsrah","is_ca":false},{"name":"Kathy Karavendzas","is_ca":false},{"name":"Brendan Griffen","is_ca":false},{"name":"Drew M. Titmarsh","is_ca":false},{"name":"David A. Elliott","is_ca":false},{"name":"James McMahon","is_ca":false},{"name":"Andreas Suhrbier","is_ca":false},{"name":"Kanta Subbarao","is_ca":false},{"name":"Enzo R. Porrello","is_ca":false},{"name":"Mark J. Smyth","is_ca":false},{"name":"Christian Engwerda","is_ca":false},{"name":"Kelli P. A. MacDonald","is_ca":false},{"name":"Tobias Bald","is_ca":false},{"name":"David E. James","is_ca":false},{"name":"James E. Hudson","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01115273077099616,"gpt":0.2303323790153184,"spread":0.2191796482443223,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763547,0.0005535387,0.0005600407,0.0003200568,0.0003047518,0.0004389029,0.0002885572,0.0003970231,0.002335906],"category_scores_gemma":[0.000166899,0.0001712855,0.0003273636,0.0002348419,0.0003150723,0.0002549524,0.0001616632,0.001262044,0.0005593187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076457,"about_ca_system_score_gemma":0.0003605607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005222993,"about_ca_topic_score_gemma":0.001420531,"domain_scores_codex":[0.9998137,0.00003203823,0.00001690155,0.00002418723,0.00003376039,0.00007940033],"domain_scores_gemma":[0.9999293,0.00001141708,0.00001655684,0.00000810558,0.000008193637,0.00002633999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004619113,0.000684376,0.0003260533,0.0001804653,0.00005404251,0.0001061283,0.00002808677,0.0004622779,0.9843598,0.0007116631,0.0008870113,0.00758092],"study_design_scores_gemma":[0.0006552265,0.002860368,0.008073014,0.00004214689,0.000101433,0.0004044125,0.0000957434,0.002716122,0.9702013,0.0003300904,0.01449722,0.00002296759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825785,0.006560002,0.002415824,0.0005970134,0.0003833575,0.00009715534,0.001220363,0.0002507319,0.005897028],"genre_scores_gemma":[0.9879951,0.003238008,0.001649452,0.0001778976,0.00007905942,0.0001000507,0.001237647,0.00003315105,0.005489654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002335906,"threshold_uncertainty_score":0.007814407,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2137429553","doi":"10.1158/0008-5472.can-15-0236","title":"Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Institutes of Health Research; Rosetrees Trust; Cancer Research UK; Wellcome Trust","keywords":"Bromodomain; Cancer research; Cancer; Leukemia; Small molecule; Cancer therapy; Medicine; Chemistry; Pharmacology; Internal medicine; Biochemistry; Epigenetics; Gene","authors":[{"name":"S. Picaud","is_ca":false},{"name":"O. Fedorov","is_ca":false},{"name":"Angeliki Thanasopoulou","is_ca":false},{"name":"Katharina Leonards","is_ca":false},{"name":"Katherine L. Jones","is_ca":false},{"name":"Julia Meier","is_ca":false},{"name":"Heidi Olzscha","is_ca":false},{"name":"Octovia Monteiro","is_ca":false},{"name":"Sarah Martin","is_ca":false},{"name":"Martin Philpott","is_ca":false},{"name":"Anthony Tumber","is_ca":false},{"name":"P. Filippakopoulos","is_ca":false},{"name":"Clarence Yapp","is_ca":false},{"name":"Christopher Wells","is_ca":false},{"name":"Ka Hing","is_ca":false},{"name":"Andrew J. Bannister","is_ca":false},{"name":"Samuel C. Robson","is_ca":false},{"name":"Umesh Kumar","is_ca":false},{"name":"Nigel J. Parr","is_ca":false},{"name":"Kevin Lee","is_ca":false},{"name":"Dave Lugo","is_ca":false},{"name":"Philip Jeffrey","is_ca":false},{"name":"S. Taylor","is_ca":false},{"name":"Matteo Vecellio","is_ca":false},{"name":"C. Bountra","is_ca":false},{"name":"Paul E. Brennan","is_ca":false},{"name":"Alison O’Mahony","is_ca":false},{"name":"Sharlene Velichko","is_ca":false},{"name":"Susanne Müller","is_ca":false},{"name":"Duncan A. Hay","is_ca":false},{"name":"Danette L. Daniels","is_ca":false},{"name":"Marjeta Urh","is_ca":false},{"name":"Nicholas B. La Thangue","is_ca":false},{"name":"Tony Kouzarides","is_ca":false},{"name":"Rab K. Prinjha","is_ca":false},{"name":"Jürg Schwaller","is_ca":false},{"name":"Stefan Knapp","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1686787036596094,"gpt":0.3887608295033915,"spread":0.2200821258437821,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335456,0.0004023412,0.0004557582,0.0002094066,0.0001343281,0.0002506664,0.0003772148,0.0002794823,0.001145217],"category_scores_gemma":[0.00007367644,0.0001448656,0.0002284211,0.000186013,0.0001526412,0.0002100619,0.0001836674,0.0007493508,0.0003860152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004374553,"about_ca_system_score_gemma":0.000297834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005580721,"about_ca_topic_score_gemma":0.001394809,"domain_scores_codex":[0.9999393,0.000006293112,0.000003592861,0.00001432872,0.00002008353,0.00001650461],"domain_scores_gemma":[0.9999779,0.000003107235,0.000005337883,0.000002254075,0.000003225054,0.000008154901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001901831,0.0001236086,0.0001119657,0.00009005712,0.00001475762,0.00007203849,0.0000126254,0.0005462331,0.9873765,0.0003581431,0.0002993742,0.01080456],"study_design_scores_gemma":[0.0003530639,0.001642872,0.001103488,0.00001022646,0.00004791531,0.0005777422,0.000009321527,0.003085588,0.9819499,0.00009879444,0.01110705,0.00001411304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9358275,0.01578342,0.03519383,0.000550431,0.0001469163,0.0006122945,0.001272448,0.0006278567,0.009985282],"genre_scores_gemma":[0.9812045,0.004736118,0.009043878,0.0001133604,0.00001679134,0.0001917119,0.0008553456,0.0000262573,0.003811957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145217,"threshold_uncertainty_score":0.003831148,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2117138389","doi":"10.1128/mcb.01297-08","title":"Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes","year":2008,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Bromodomain; Histone acetyltransferase; PHD finger; Zinc finger; Acetyltransferase; Acetylation; Biology; Histone; PCAF; Enhancer; Chromatin; Genetics; Histone H3; Cell biology; Chemistry; Transcription factor; Gene","authors":[{"name":"Mukta Ullah","is_ca":true},{"name":"Nadine Pelletier","is_ca":true},{"name":"Lin Xiao","is_ca":true},{"name":"Songping Zhao","is_ca":true},{"name":"Kainan Wang","is_ca":true},{"name":"Cindy Degerny","is_ca":true},{"name":"Soroush Tahmasebi","is_ca":true},{"name":"Christelle Cayrou","is_ca":true},{"name":"Yannick Doyon","is_ca":true},{"name":"Siew-Lee Goh","is_ca":true},{"name":"Nathalie Champagne","is_ca":true},{"name":"Jacques Côté","is_ca":true},{"name":"Xiang-Jiao Yang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007204628355651102,"gpt":0.2300025420595001,"spread":0.222797913703849,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005742772,0.0002369586,0.0001637828,0.0002266275,0.0002795644,0.0004768114,0.0004033225,0.0002774354,0.00169949],"category_scores_gemma":[0.0001123875,0.0002700185,0.0002208046,0.0001055499,0.000127815,0.0002971545,0.0002040904,0.0003199989,0.0007007008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007726633,"about_ca_system_score_gemma":0.0001631234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001286182,"about_ca_topic_score_gemma":0.001657773,"domain_scores_codex":[0.9999359,0.000003852822,0.000002568242,0.00002838484,0.00001198503,0.00001720588],"domain_scores_gemma":[0.9999141,0.000006981385,0.00002469052,0.000006588998,0.000009140278,0.0000385313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003013198,0.00005441681,0.001786457,0.00005062422,0.00002497423,0.000178683,0.00007746366,0.000507664,0.993063,0.001140956,0.0001952282,0.002619253],"study_design_scores_gemma":[0.0002752292,0.0006923761,0.1657506,0.00004858329,0.0001136776,0.00188072,0.0003231647,0.06896784,0.7392487,0.003754316,0.0188643,0.0000805489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946712,0.0007657549,0.002863747,0.0001108225,0.00001313599,0.00001801364,0.0001370647,0.0001548215,0.001265513],"genre_scores_gemma":[0.9959316,0.00025933,0.001498227,0.0000566822,0.000009455723,0.00001216733,0.0005729738,0.00001675481,0.001642864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169949,"threshold_uncertainty_score":0.005685329,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2780843582","doi":"10.1038/nature25169","title":"Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":227,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre; McMaster University; SickKids Foundation; University Health Network; University of Toronto; Ontario Institute for Cancer Research; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"Ependymoma; Enhancer; Profiling (computer programming); Computational biology; Biology; Cancer research; Medicine; Genetics; Pathology; Gene; Computer science; Transcription factor","authors":[{"name":"Stephen C. Mack","is_ca":false},{"name":"Kristian W. Pajtler","is_ca":false},{"name":"Lukas Chávez","is_ca":false},{"name":"Konstantin Okonechnikov","is_ca":false},{"name":"Kelsey C. Bertrand","is_ca":false},{"name":"Xiuxing Wang","is_ca":false},{"name":"Serap Erkek","is_ca":false},{"name":"Alexander Federation","is_ca":false},{"name":"Anne Song","is_ca":false},{"name":"Christine Lee","is_ca":false},{"name":"Xin Wang","is_ca":false},{"name":"Laura McDonald","is_ca":true},{"name":"James J. Morrow","is_ca":false},{"name":"Alina Saiakhova","is_ca":false},{"name":"Patrick Sin‐Chan","is_ca":true},{"name":"Qiulian Wu","is_ca":false},{"name":"Kulandaimanuvel Antony Michealraj","is_ca":true},{"name":"Tyler E. Miller","is_ca":false},{"name":"Christopher G. Hubert","is_ca":false},{"name":"Marina Ryzhova","is_ca":false},{"name":"Livia Garzia","is_ca":true},{"name":"Laura Donovan","is_ca":true},{"name":"Stephen M. Dombrowski","is_ca":false},{"name":"Daniel C. Factor","is_ca":false},{"name":"Betty Luu","is_ca":true},{"name":"Claudia L.L. Valentim","is_ca":false},{"name":"Ryan C. Gimple","is_ca":false},{"name":"Andrew R. Morton","is_ca":false},{"name":"Leo J.Y. Kim","is_ca":false},{"name":"Briana C. Prager","is_ca":false},{"name":"John J. Y. Lee","is_ca":true},{"name":"Xiaochong Wu","is_ca":true},{"name":"Jennifer Zuccaro","is_ca":true},{"name":"Yuan Thompson","is_ca":true},{"name":"Borja Holgado","is_ca":true},{"name":"Jüri Reimand","is_ca":true},{"name":"Susan Q. Ke","is_ca":false},{"name":"Adam Tropper","is_ca":false},{"name":"Sisi Lai","is_ca":false},{"name":"Senthuran Vijayarajah","is_ca":false},{"name":"Sylvia Doan","is_ca":false},{"name":"Vaidehi Mahadev","is_ca":false},{"name":"Ana Fernández‐Miñán","is_ca":false},{"name":"Susanne Gröbner","is_ca":false},{"name":"Matthias Lienhard","is_ca":false},{"name":"Marc Zapatka","is_ca":false},{"name":"Zhiqin Huang","is_ca":false},{"name":"Kenneth Aldape","is_ca":true},{"name":"Ángel M. Carcaboso","is_ca":false},{"name":"Peter J. Houghton","is_ca":false},{"name":"Stephen T. Keir","is_ca":false},{"name":"Till Milde","is_ca":false},{"name":"Hendrik Witt","is_ca":false},{"name":"Yan Li","is_ca":false},{"name":"Chaojun Li","is_ca":false},{"name":"Xiu‐Wu Bian","is_ca":false},{"name":"David Jones","is_ca":false},{"name":"Ian C. Scott","is_ca":true},{"name":"Sheila K. Singh","is_ca":true},{"name":"Annie Huang","is_ca":true},{"name":"Peter B. Dirks","is_ca":true},{"name":"Éric Bouffet","is_ca":true},{"name":"James E. Bradner","is_ca":false},{"name":"Vijay Ramaswamy","is_ca":true},{"name":"Nada Jabado","is_ca":true},{"name":"James T. Rutka","is_ca":true},{"name":"Paul A. Northcott","is_ca":false},{"name":"Mathieu Lupien","is_ca":true},{"name":"Peter Lichter","is_ca":false},{"name":"Andrey Korshunov","is_ca":false},{"name":"Peter C. Scacheri","is_ca":false},{"name":"Stefan M. Pfister","is_ca":false},{"name":"Marcel Kool","is_ca":false},{"name":"Michael D. Taylor","is_ca":true},{"name":"Jeremy N. Rich","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006555520905130795,"gpt":0.2965779770880875,"spread":0.2900224561829567,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002858868,0.0002767871,0.0002577271,0.0002524309,0.0001576638,0.0005245178,0.0002489796,0.000318591,0.00141421],"category_scores_gemma":[0.0001916329,0.0001377718,0.0001649443,0.0001443651,0.0002195758,0.0003509613,0.0002368226,0.0008727887,0.000297861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274488,"about_ca_system_score_gemma":0.0002094964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001836551,"about_ca_topic_score_gemma":0.0005571314,"domain_scores_codex":[0.9999057,0.00001302012,0.000005281898,0.00001945446,0.00003085433,0.00002570364],"domain_scores_gemma":[0.9999471,0.00001592755,0.00001278759,0.00000956382,0.000005409766,0.000009306917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007053953,0.0001536166,0.0006033755,0.00007348421,0.00001646634,0.0004583138,0.00003317861,0.00176293,0.9609318,0.005046026,0.0005170746,0.02969823],"study_design_scores_gemma":[0.00008685967,0.0004910893,0.001669204,0.00001183586,0.00003848799,0.001271797,0.00002250914,0.006050618,0.9754393,0.001286554,0.01362163,0.00001018352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9310822,0.004050015,0.04517272,0.0007721257,0.0001531422,0.0001824964,0.0005479046,0.0005734029,0.01746597],"genre_scores_gemma":[0.9884827,0.001231833,0.006858579,0.00007863917,0.00001417777,0.00004666269,0.0001831391,0.00004623695,0.003058242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141421,"threshold_uncertainty_score":0.004730999,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2286718346","doi":"10.1021/acs.jmedchem.5b01865","title":"Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Structural Genomics Consortium; National Cancer Institute; National Institutes of Health; Ministero dello Sviluppo Economico; Österreichische Forschungsförderungsgesellschaft; Boehringer Ingelheim Fonds; Ontario Ministry of Economic Development and Innovation; Pershing Square Sohn Cancer Research Alliance; Wellcome Trust; Genome Canada; Boehringer Ingelheim; Pfizer; Eli Lilly and Company; Canadian Institutes of Health Research; Wellcome; Pershing Square Foundation; GlaxoSmithKline; Burroughs Wellcome Fund","keywords":"Chemistry; In vivo; Structure–activity relationship; Stereochemistry; Pharmacology; In vitro; Biochemistry","authors":[{"name":"Laetitia J. Martin","is_ca":false},{"name":"Manfred Koegl","is_ca":false},{"name":"Gerd Bader","is_ca":false},{"name":"Xiaoling Cockcroft","is_ca":false},{"name":"O. Fedorov","is_ca":false},{"name":"Dennis Fiegen","is_ca":false},{"name":"Thomas Gerstberger","is_ca":false},{"name":"Marco H. Hofmann","is_ca":false},{"name":"Anja Hohmann","is_ca":false},{"name":"Dirk Kessler","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Petr Knesl","is_ca":false},{"name":"Stefan Kornigg","is_ca":false},{"name":"Susanne Müller","is_ca":false},{"name":"Herbert Nar","is_ca":false},{"name":"Catherine Rogers","is_ca":false},{"name":"Klaus Rumpel","is_ca":false},{"name":"Otmar Schaaf","is_ca":false},{"name":"Steffen Steurer","is_ca":false},{"name":"C. Tallant","is_ca":false},{"name":"Christopher R. Vakoc","is_ca":false},{"name":"Markus Zeeb","is_ca":false},{"name":"Andreas Zoephel","is_ca":false},{"name":"Mark Pearson","is_ca":false},{"name":"Guido Boehmelt","is_ca":false},{"name":"Darryl B. McConnell","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00775703748647166,"gpt":0.2445047407153881,"spread":0.2367477032289164,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772384,0.0003724273,0.0003885298,0.0002160499,0.0001617506,0.0003607329,0.0005207562,0.0002938476,0.001368152],"category_scores_gemma":[0.0001157229,0.000213026,0.0002196476,0.0001657302,0.0001543654,0.0001922418,0.0001605458,0.0005033216,0.0005181755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006122161,"about_ca_system_score_gemma":0.0004449626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000664209,"about_ca_topic_score_gemma":0.001413337,"domain_scores_codex":[0.9999253,0.00001356363,0.000007273599,0.00001593045,0.00001914234,0.00001883229],"domain_scores_gemma":[0.9999641,0.000004402167,0.00000873149,0.000003430026,0.00000682832,0.00001255324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004489268,0.0002684834,0.0001574601,0.0001459333,0.00002240534,0.0001285254,0.00002178599,0.004001586,0.9845883,0.0009493593,0.0003475577,0.008919588],"study_design_scores_gemma":[0.0006859192,0.002449775,0.0008487777,0.00001673572,0.0000687,0.0004298208,0.00002175306,0.009144403,0.9701412,0.0001836599,0.01598535,0.00002397281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495021,0.005068477,0.03260553,0.0005577793,0.0001327665,0.0009571004,0.001635217,0.00038803,0.009153072],"genre_scores_gemma":[0.9741994,0.003425328,0.01680064,0.0001597882,0.00001521013,0.0001704492,0.001466617,0.00002679429,0.003735779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368152,"threshold_uncertainty_score":0.004576981,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4292295879","doi":"10.1039/d2cs00387b","title":"Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders","year":2022,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; FP7 Ideas: European Research Council; Biotechnology and Biological Sciences Research Council; European Commission; Directorate for Biological Sciences; European Federation of Pharmaceutical Industries and Associations; Horizon 2020 Framework Programme; University of Dundee; H2020 Marie Skłodowska-Curie Actions; Innovative Medicines Initiative; McGill University","keywords":"DNA ligase; Ubiquitin ligase; Small molecule; Chemistry; Computational biology; Combinatorial chemistry; Biochemistry; Stereochemistry; Ubiquitin; DNA; Biology; Gene","authors":[{"name":"Claudia J. Diehl","is_ca":false},{"name":"Alessio Ciulli","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05672681427050509,"gpt":0.2969829266204442,"spread":0.2402561123499391,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004416927,0.0009752946,0.0008183511,0.001603492,0.0002186939,0.0007631199,0.0007550321,0.0009576935,0.002127264],"category_scores_gemma":[0.0005566632,0.0003834164,0.0004058878,0.001285654,0.0003861536,0.001160031,0.0005931833,0.002213782,0.002336915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008187423,"about_ca_system_score_gemma":0.0005713021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006508044,"about_ca_topic_score_gemma":0.001089731,"domain_scores_codex":[0.9998223,0.00002710684,0.00001531792,0.00003200351,0.00007780832,0.00002541944],"domain_scores_gemma":[0.9998571,0.00005411558,0.00002090713,0.000006587278,0.00004340006,0.00001802261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001312139,0.0001514892,0.000126935,0.01301226,0.000108493,0.0003394271,0.00007961136,0.001258278,0.01440091,0.01698232,0.0652681,0.888141],"study_design_scores_gemma":[0.00001626207,0.00009375541,0.000208475,0.0007077125,0.00003602178,0.0004283795,0.00001553088,0.00015784,0.002446109,0.001057497,0.9948191,0.00001332773],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003910683,0.9958701,0.0005396194,0.000312728,0.0004861744,0.00001120491,0.00002991747,0.00002405929,0.002335196],"genre_scores_gemma":[0.002125698,0.9941585,0.0005058623,0.0003729269,0.0002091882,0.00002083173,0.00006024638,0.00000528244,0.002541492],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002127264,"threshold_uncertainty_score":0.007116377,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2063887542","doi":"10.1021/jm200640v","title":"3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Cancer Research UK; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Bromodomain; Acetylation; Chemistry; BRD4; Histone; Lysine; Epigenetics; Biochemistry; Chromatin; PHD finger; Histone Acetyltransferases; Transcription factor; Computational biology; Gene; Biology; Amino acid","authors":[{"name":"David S. Hewings","is_ca":false},{"name":"Minghua Wang","is_ca":false},{"name":"Martin Philpott","is_ca":false},{"name":"O. Fedorov","is_ca":false},{"name":"Sagar Uttarkar","is_ca":false},{"name":"P. Filippakopoulos","is_ca":false},{"name":"S. Picaud","is_ca":false},{"name":"Chaitanya Vuppusetty","is_ca":false},{"name":"Brian D. Marsden","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Stuart J. Conway","is_ca":false},{"name":"Tom D. Heightman","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01290468324358886,"gpt":0.2417098870984178,"spread":0.228805203854829,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477496,0.0005180276,0.000441867,0.0001837541,0.0001239319,0.0002311346,0.0008447265,0.0002910386,0.001327569],"category_scores_gemma":[0.0001783087,0.0002037857,0.0002703969,0.0002024919,0.0002615527,0.0002229353,0.0001714993,0.0006460235,0.0005968456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000355987,"about_ca_system_score_gemma":0.000187346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395533,"about_ca_topic_score_gemma":0.0009326192,"domain_scores_codex":[0.9998716,0.00003504186,0.000008937792,0.00001952387,0.00003188463,0.00003287461],"domain_scores_gemma":[0.9999262,0.00001747939,0.00002438628,0.000008278581,0.00001058336,0.00001297576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003658842,0.0001050104,0.0001963774,0.0002045578,0.00002217085,0.00009489356,0.00002520013,0.00082422,0.9917778,0.0005532068,0.0002312878,0.005599444],"study_design_scores_gemma":[0.000223516,0.001656071,0.001274514,0.0000115698,0.0000303118,0.000348828,0.00002160071,0.0009974893,0.9846761,0.000108916,0.01063447,0.00001664253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437144,0.02965044,0.01692786,0.0003632696,0.0001414289,0.0002922806,0.001000809,0.0003389156,0.007570666],"genre_scores_gemma":[0.9709868,0.01232021,0.01024202,0.0001736848,0.00002910802,0.0001273099,0.0008957385,0.00002305249,0.005202105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327569,"threshold_uncertainty_score":0.004441202,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3100577837","doi":"10.1182/blood.2020008676","title":"CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Energy; International Development Research Centre; Office of Science; Government of Ontario; Bristol-Myers Squibb","keywords":"Cereblon; Ubiquitin ligase; Cancer research; Cell biology; Integrated stress response; Stem cell; Chemistry; Biology; Myeloid leukemia; Leukemia; Ubiquitin; Immunology; Biochemistry; Translation (biology)","authors":[{"name":"Christine Surka","is_ca":false},{"name":"Liqing Jin","is_ca":true},{"name":"Nathan Mbong","is_ca":true},{"name":"Chin-Chun Lu","is_ca":false},{"name":"In Sock Jang","is_ca":false},{"name":"Emily Rychak","is_ca":false},{"name":"Derek Mendy","is_ca":false},{"name":"Thomas Clayton","is_ca":false},{"name":"Elizabeth A. Tindall","is_ca":false},{"name":"Christy Hsu","is_ca":false},{"name":"Celia Fontanillo","is_ca":false},{"name":"Eileen Tran","is_ca":false},{"name":"Adrian Contreras","is_ca":false},{"name":"Stanley Ng","is_ca":true},{"name":"Mary E. Matyskiela","is_ca":false},{"name":"Kai Wang","is_ca":false},{"name":"Philip P. Chamberlain","is_ca":false},{"name":"Brian E. Cathers","is_ca":false},{"name":"James Carmichael","is_ca":false},{"name":"Joshua D. Hansen","is_ca":false},{"name":"Jean Wang","is_ca":true},{"name":"Mark D. Minden","is_ca":true},{"name":"Jinhong Fan","is_ca":false},{"name":"Daniel W. Pierce","is_ca":false},{"name":"Michael Pourdehnad","is_ca":false},{"name":"Mark Rolfe","is_ca":false},{"name":"Antonia Lopez‐Girona","is_ca":false},{"name":"John E. Dick","is_ca":true},{"name":"Gang Lu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009025599242421198,"gpt":0.202692558490278,"spread":0.1936669592478568,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032403,0.0003570164,0.0002782023,0.000244089,0.0001151208,0.0002609471,0.0002292672,0.0002391962,0.0008380628],"category_scores_gemma":[0.00009988754,0.0001095758,0.0001962386,0.0001881482,0.0001754949,0.0001226134,0.0001782079,0.0003877952,0.0002774098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004909692,"about_ca_system_score_gemma":0.0002603991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005930756,"about_ca_topic_score_gemma":0.001631634,"domain_scores_codex":[0.9998873,0.00001194979,0.00001021614,0.00002522107,0.00004861243,0.00001659578],"domain_scores_gemma":[0.9999499,0.000004433906,0.00001625721,0.000004179175,0.000008546691,0.00001670064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002354329,0.00004752998,0.0009683428,0.00007861744,0.00002083421,0.0001015004,0.00001032473,0.0004502725,0.9833192,0.0002940389,0.0003621096,0.01411172],"study_design_scores_gemma":[0.00008284892,0.0005345672,0.004190894,0.000005642856,0.00003370026,0.0009781158,0.00001238882,0.001306304,0.9803526,0.00006950799,0.01242569,0.000007624627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792607,0.006889266,0.006967187,0.0002855918,0.00005298052,0.0001611884,0.0009551508,0.0005591668,0.00486873],"genre_scores_gemma":[0.9891503,0.002738107,0.00414682,0.0001381115,0.00001073388,0.00005643785,0.001318139,0.0000260522,0.002415254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008380628,"threshold_uncertainty_score":0.003562212,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2984431814","doi":"10.1093/jncics/pkz093","title":"Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors","year":2019,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ottawa Hospital","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; GlaxoSmithKline","keywords":"Bromodomain; Medicine; Nut; Cancer research; Internal medicine; Biochemistry; Biology","authors":[{"name":"Sarina A. Piha‐Paul","is_ca":false},{"name":"Christine L. Hann","is_ca":false},{"name":"Christopher A. French","is_ca":false},{"name":"Sophie Cousin","is_ca":false},{"name":"Irene Braña","is_ca":false},{"name":"Phillippe A. Cassier","is_ca":false},{"name":"Víctor Moreno","is_ca":false},{"name":"Johann S. de Bono","is_ca":false},{"name":"Sara Harward","is_ca":false},{"name":"Geraldine Ferron‐Brady","is_ca":false},{"name":"Olena Barbash","is_ca":false},{"name":"Anastasia Wyce","is_ca":false},{"name":"Yuehui Wu","is_ca":false},{"name":"Thierry Horner","is_ca":false},{"name":"Meg Annan","is_ca":false},{"name":"Nigel J. Parr","is_ca":false},{"name":"Rabinder Prinjha","is_ca":true},{"name":"Christopher L. Carpenter","is_ca":false},{"name":"John Hilton","is_ca":true},{"name":"David S. Hong","is_ca":true},{"name":"Naomi B. Haas","is_ca":false},{"name":"Mark C. Markowski","is_ca":false},{"name":"Arindam Dhar","is_ca":false},{"name":"Peter J. O’Dwyer","is_ca":false},{"name":"Geoffrey I. Shapiro","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009424531050998724,"gpt":0.2753434312589721,"spread":0.2659189002079734,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001065549,0.0009387463,0.001323024,0.0003080971,0.0002662237,0.0005465148,0.0005404889,0.0006182507,0.00214183],"category_scores_gemma":[0.0004832575,0.0004181028,0.0007026932,0.0002397138,0.0004384305,0.0004901902,0.0002372343,0.001528278,0.0004356914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007215521,"about_ca_system_score_gemma":0.001178541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009418497,"about_ca_topic_score_gemma":0.002781135,"domain_scores_codex":[0.9997033,0.0001370436,0.00001647759,0.00005989162,0.00003423428,0.00004908205],"domain_scores_gemma":[0.999597,0.00006060104,0.00009339026,0.00003825265,0.00003513475,0.0001755979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3806081,0.09168784,0.01900738,0.001207013,0.001519341,0.0006328506,0.0005055937,0.006273718,0.3617728,0.0004490143,0.005467957,0.1308684],"study_design_scores_gemma":[0.1887728,0.7442897,0.02181416,0.0000286469,0.0006102854,0.0007297819,0.00007250774,0.003240479,0.0356748,0.0001953602,0.004537352,0.0000340798],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946997,0.001333409,0.0006622734,0.0001396737,0.00003614935,0.001463583,0.0007615096,0.0000799602,0.0008237251],"genre_scores_gemma":[0.9924098,0.0009828135,0.001702344,0.000285671,0.0000444775,0.001183997,0.001629269,0.00002572459,0.001735843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00214183,"threshold_uncertainty_score":0.007165134,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2604744033","doi":"10.1021/acs.jmedchem.6b01781","title":"A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Discovery Centre","funders":"","keywords":"Linker; Bromodomain; Ubiquitin ligase; Chemistry; Ubiquitin; DNA ligase; Protein degradation; Target protein; Click chemistry; Ternary complex; Proteolysis; Native chemical ligation; Small molecule; Biochemistry; Ubiquitin-Protein Ligases; Cell biology; Combinatorial chemistry; Chemical synthesis; DNA; Biology; Enzyme; In vitro","authors":[{"name":"Ryan P. Wurz","is_ca":false},{"name":"Ken Dellamaggiore","is_ca":true},{"name":"Hannah Dou","is_ca":false},{"name":"Noelle Javier","is_ca":false},{"name":"Mei-Chu Lo","is_ca":false},{"name":"John D. McCarter","is_ca":true},{"name":"Dane Mohl","is_ca":true},{"name":"Christine Sastri","is_ca":true},{"name":"J. Russell Lipford","is_ca":true},{"name":"Victor J. Cee","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02649876102437507,"gpt":0.2790411026217938,"spread":0.2525423415974187,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004170819,0.0006863317,0.0002614258,0.0003678814,0.0001911172,0.0002749169,0.0004769821,0.0005597443,0.002262618],"category_scores_gemma":[0.0002536038,0.0003072218,0.0003946324,0.0002363252,0.0002774135,0.0005545343,0.0003095342,0.0008367423,0.001063959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003541639,"about_ca_system_score_gemma":0.0002706502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306892,"about_ca_topic_score_gemma":0.0003942679,"domain_scores_codex":[0.9997534,0.00004253203,0.00001657409,0.00006447251,0.00008402034,0.00003895581],"domain_scores_gemma":[0.999878,0.0000255841,0.0000407812,0.00001704964,0.00001297349,0.00002551986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008263726,0.0000525561,0.00005151073,0.00008421114,0.00001203761,0.00008735254,0.00001236077,0.0002033715,0.9920815,0.0007718207,0.0003342991,0.006226202],"study_design_scores_gemma":[0.00001825597,0.0002854288,0.000215494,0.000002943104,0.00001214112,0.000310081,0.000002755876,0.0009036082,0.9917262,0.00008051135,0.006431642,0.00001099714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6146052,0.007871475,0.3549159,0.0008562143,0.0004644431,0.0008839306,0.001898464,0.004501288,0.01400308],"genre_scores_gemma":[0.8509336,0.003675628,0.1305148,0.0004813382,0.0000866734,0.000446888,0.00147267,0.0001443984,0.01224414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262618,"threshold_uncertainty_score":0.007569253,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2560915683","doi":"10.1021/jacs.6b11467","title":"Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":201,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Structural Genomics Consortium; Engineering and Physical Sciences Research Council; Wellcome Trust; Wellcome","keywords":"Chemistry; Isothermal titration calorimetry; Affinities; Bromodomain; Binding affinities; Selectivity; Molecular dynamics; Computational chemistry; Ligand (biochemistry); Binding energy; Interaction energy; Free energy perturbation; Biological system; Stereochemistry; Molecule; Physical chemistry","authors":[{"name":"Matteo Aldeghi","is_ca":false},{"name":"Alexander Heifetz","is_ca":false},{"name":"Michael J. Bodkin","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Philip C. Biggin","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006635071517930045,"gpt":0.2259788436639183,"spread":0.2193437721459883,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438576,0.0006929691,0.0006944296,0.0007542842,0.0003209129,0.0005209327,0.0008508672,0.0005890247,0.001352826],"category_scores_gemma":[0.00360921,0.0003637144,0.0004963895,0.0004535351,0.0003504274,0.0005717747,0.000389423,0.0007877177,0.0004831601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000769363,"about_ca_system_score_gemma":0.0008948178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002728025,"about_ca_topic_score_gemma":0.002100501,"domain_scores_codex":[0.999485,0.0001415528,0.00002604563,0.00006471104,0.0002242399,0.00005832334],"domain_scores_gemma":[0.998566,0.0009786854,0.00009552401,0.0001167713,0.0001969125,0.000046202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001575263,0.0000554026,0.002352099,0.00007502107,0.00002651197,0.00004476271,0.00002410607,0.952861,0.02695107,0.003425422,0.0004291797,0.01359791],"study_design_scores_gemma":[0.000009161409,0.00003951847,0.0004190387,0.000003196162,0.000004459169,0.00001262321,0.000006032157,0.9877325,0.0102463,0.001340226,0.0001795546,0.000007429401],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6727542,0.0005279382,0.3180772,0.0002195426,0.00003359537,0.00008790282,0.0007035757,0.001282151,0.006313873],"genre_scores_gemma":[0.959572,0.0001876437,0.03886996,0.00005202593,0.000007313796,0.0001267041,0.0004073288,0.00009107511,0.0006860315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002728025,"threshold_uncertainty_score":0.007607996,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1966585118","doi":"10.1371/journal.pone.0083190","title":"RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Resverlogix (Canada)","funders":"Alberta Innovates","keywords":"Bromodomain; BRD4; Epigenetics; Apolipoprotein B; Inducer; BET inhibitor; Binding site; Chemistry; Acetylation; In vivo; Biology; Biochemistry; Cholesterol; Genetics; Gene","authors":[{"name":"Kevin G. McLure","is_ca":true},{"name":"Emily M. Gesner","is_ca":true},{"name":"Laura Tsujikawa","is_ca":true},{"name":"Olesya A. Kharenko","is_ca":true},{"name":"Sarah Attwell","is_ca":true},{"name":"Eric Campeau","is_ca":true},{"name":"Sylwia Wasiak","is_ca":true},{"name":"Adam J. Stein","is_ca":false},{"name":"André White","is_ca":false},{"name":"Eric Fontano","is_ca":false},{"name":"R.K. Suto","is_ca":false},{"name":"Norman C.W. Wong","is_ca":true},{"name":"Gregory S. Wagner","is_ca":true},{"name":"Henrik C. Hansen","is_ca":true},{"name":"Peter R. Young","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03025521576782595,"gpt":0.2369448331627485,"spread":0.2066896173949225,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726354,0.0002162931,0.0003079459,0.0002132782,0.0001248569,0.0001801104,0.0001774474,0.00028441,0.002054099],"category_scores_gemma":[0.0001166849,0.0001181873,0.0001663843,0.000114687,0.0002063272,0.00008102224,0.0001270747,0.0005359537,0.0006016576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001834439,"about_ca_system_score_gemma":0.0001145016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001660245,"about_ca_topic_score_gemma":0.000252453,"domain_scores_codex":[0.9999237,0.00002070101,0.000005706764,0.00001512329,0.00001982948,0.00001500704],"domain_scores_gemma":[0.9999635,0.000008994744,0.00001042443,0.000004459248,0.000002444432,0.0000101099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001926172,0.000353348,0.001227925,0.0001330171,0.00002970777,0.0004030911,0.00002710119,0.0001723678,0.9642925,0.0006395021,0.0007321269,0.03006316],"study_design_scores_gemma":[0.001090605,0.008439359,0.01749301,0.00002705161,0.00009928455,0.006420069,0.00005016222,0.001056609,0.9245218,0.0004094467,0.04036548,0.00002703936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816111,0.006911942,0.004136354,0.0005341735,0.0001152487,0.0001053669,0.0007174213,0.0002476453,0.005620746],"genre_scores_gemma":[0.9851683,0.002459705,0.004636618,0.0002792722,0.00003826684,0.0001228939,0.0009899422,0.00002817761,0.006276729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002054099,"threshold_uncertainty_score":0.006871641,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2096783705","doi":"10.1021/jm3010515","title":"Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; Novartis Foundation; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Acetylation; Histone Acetyltransferases; Chemistry; Histone; BRD4; Small molecule; Epigenetics; Chromatin; Biochemistry; Histone acetyltransferase; Lysine; Structure–activity relationship; Computational biology; In vitro; Amino acid; DNA; Biology; Gene","authors":[{"name":"Paul V. Fish","is_ca":false},{"name":"P. Filippakopoulos","is_ca":false},{"name":"Gerwyn Bish","is_ca":false},{"name":"Paul E. Brennan","is_ca":false},{"name":"Mark E. Bunnage","is_ca":false},{"name":"Andrew S. Cook","is_ca":false},{"name":"Oleg Federov","is_ca":false},{"name":"Brian S. Gerstenberger","is_ca":false},{"name":"Hannah M. Jones","is_ca":false},{"name":"Stefan Knapp","is_ca":false},{"name":"Brian D. Marsden","is_ca":false},{"name":"Karl Nocka","is_ca":false},{"name":"Dafydd R. Owen","is_ca":false},{"name":"Martin Philpott","is_ca":false},{"name":"S. Picaud","is_ca":false},{"name":"Michael J. Primiano","is_ca":false},{"name":"Michael J. Ralph","is_ca":false},{"name":"Nunzio Sciammetta","is_ca":false},{"name":"John D. Trzupek","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01162130374228581,"gpt":0.2608740894839077,"spread":0.2492527857416219,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002971522,0.000451698,0.0003454456,0.000318389,0.000178776,0.0002547411,0.0005139193,0.0003947929,0.001672129],"category_scores_gemma":[0.000253944,0.0001788183,0.000297942,0.0002357406,0.0002655089,0.0002258483,0.0002707465,0.0006856589,0.0003409232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000426232,"about_ca_system_score_gemma":0.0004031038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006372799,"about_ca_topic_score_gemma":0.001460064,"domain_scores_codex":[0.9998415,0.00002527218,0.000008325929,0.00003128362,0.0000493038,0.00004422654],"domain_scores_gemma":[0.9998988,0.00002471979,0.0000271737,0.000009350219,0.00001760855,0.00002228438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003005523,0.000189213,0.0002002954,0.00009251763,0.00002209233,0.0001942271,0.00003984127,0.002235807,0.9872809,0.0008073873,0.0001743627,0.008462694],"study_design_scores_gemma":[0.0001978713,0.002934609,0.0007765517,0.000008035919,0.00004212372,0.0004055127,0.00001985416,0.002131571,0.9893107,0.0001593097,0.003998928,0.00001493875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9490367,0.003365718,0.03818412,0.0004166595,0.00006639878,0.0005824358,0.0008538087,0.0002404622,0.007253797],"genre_scores_gemma":[0.9803541,0.002142751,0.01360672,0.0001800993,0.00001773421,0.0001437916,0.0005982782,0.00002206702,0.002934468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672129,"threshold_uncertainty_score":0.005593777,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2196777184","doi":"10.1039/c5sc03115j","title":"A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain","year":2015,"lang":"en","type":"article","venue":"Chemical Science","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":191,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Structural Genomics Consortium","funders":"Janssen Pharmaceuticals; Engineering and Physical Sciences Research Council; Ministero dello Sviluppo Economico; Swansea University; Worldwide Cancer Research; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Takeda Pharmaceutical Company; European Federation of Pharmaceutical Industries and Associations; AbbVie; Wellcome; Merck; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Novartis Pharma; Novartis; European Commission; Pfizer","keywords":"Bromodomain; Fragment (logic); Chemistry; Combinatorial chemistry; Stereochemistry; Computational biology; Biochemistry; Computer science; Biology; Epigenetics; Algorithm","authors":[{"name":"Oakley B. Cox","is_ca":true},{"name":"T. Krojer","is_ca":true},{"name":"P.M. Collins","is_ca":false},{"name":"Octovia Monteiro","is_ca":true},{"name":"R. Talon","is_ca":true},{"name":"A.R. Bradley","is_ca":true},{"name":"O. Fedorov","is_ca":true},{"name":"Jahangir Amin","is_ca":false},{"name":"Brian D. Marsden","is_ca":true},{"name":"John Spencer","is_ca":false},{"name":"F. von Delft","is_ca":true},{"name":"Paul E. Brennan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02217427758218534,"gpt":0.2444993015377055,"spread":0.2223250239555202,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002942662,0.0009244618,0.00077834,0.0005981899,0.000272898,0.0005258361,0.0005444582,0.0005062483,0.00480257],"category_scores_gemma":[0.0004127125,0.0002718222,0.000417381,0.0005733775,0.0004157654,0.000405068,0.0006636762,0.00139016,0.00245008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000399459,"about_ca_system_score_gemma":0.0003349826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004384978,"about_ca_topic_score_gemma":0.0009362347,"domain_scores_codex":[0.9997302,0.00002741651,0.00001472025,0.00005781746,0.0001051247,0.00006473414],"domain_scores_gemma":[0.9998535,0.00003454389,0.00002155178,0.00002313285,0.0000245051,0.00004268368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003040177,0.0001299673,0.0001511445,0.0001096978,0.00001872421,0.0002051024,0.00004928259,0.0005227419,0.9820055,0.0002972092,0.0004874029,0.01571921],"study_design_scores_gemma":[0.0001108262,0.002000406,0.001305028,0.00001953197,0.00006133762,0.001268103,0.00004167294,0.0009324002,0.9732463,0.0001719469,0.02080162,0.00004089432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8582169,0.007845904,0.1032251,0.0005993099,0.0002635941,0.001372213,0.007156842,0.002106037,0.01921411],"genre_scores_gemma":[0.9267392,0.003844702,0.03993777,0.0003799071,0.00004806662,0.00060672,0.01096714,0.000249197,0.01722734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00480257,"threshold_uncertainty_score":0.01606625,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2904329518","doi":"10.1016/j.molcel.2018.11.006","title":"Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Heart and Stroke Foundation; University of Toronto; SickKids Foundation; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Structural Genomics Consortium; National Institute of General Medical Sciences; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Uehara Memorial Foundation; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Medical Research Council; Cancer Research Society; Genome Canada; Boehringer Ingelheim; University of Toronto; Eesti Teadusagentuur; AbbVie; Merck; Pfizer; Natural Sciences and Engineering Research Council of Canada; Alfred P. Sloan Foundation","keywords":"Bromodomain; Interactome; BRD4; BET inhibitor; Biology; Computational biology; Protein–protein interaction; Chromatin; Plasma protein binding; Genetics; Acetylation; Gene; Cell biology","authors":[{"name":"Jean‐Philippe Lambert","is_ca":true},{"name":"S. Picaud","is_ca":false},{"name":"Takao Fujisawa","is_ca":false},{"name":"Huayun Hou","is_ca":true},{"name":"P. Savitsky","is_ca":false},{"name":"Liis Uusküla-Reimand","is_ca":true},{"name":"Gagan D. Gupta","is_ca":true},{"name":"Hala Abdouni","is_ca":true},{"name":"Zhen‐Yuan Lin","is_ca":true},{"name":"Monika Tucholska","is_ca":true},{"name":"James D.R. Knight","is_ca":true},{"name":"Beatriz Gonzalez-Badillo","is_ca":true},{"name":"Nicole St‐Denis","is_ca":true},{"name":"J.A. Newman","is_ca":false},{"name":"Manuel Stucki","is_ca":false},{"name":"Laurence Pelletier","is_ca":true},{"name":"Nuno Bandeira","is_ca":false},{"name":"Michael D. Wilson","is_ca":true},{"name":"P. Filippakopoulos","is_ca":false},{"name":"Anne‐Claude Gingras","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007724121999411446,"gpt":0.2632018455588547,"spread":0.2554777235594433,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240755,0.0001895086,0.0004138255,0.0002560138,0.0002034027,0.0003458073,0.0001561772,0.0002621021,0.001965956],"category_scores_gemma":[0.0001345208,0.0001354549,0.0003287086,0.0001818459,0.0002205338,0.0002504546,0.0001922872,0.0005982892,0.00040204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806816,"about_ca_system_score_gemma":0.0001415534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004994501,"about_ca_topic_score_gemma":0.001107244,"domain_scores_codex":[0.9997774,0.00001849769,0.0000141353,0.00004801258,0.00006604652,0.00007591931],"domain_scores_gemma":[0.9999074,0.000019982,0.00002467689,0.00001019659,0.00001096215,0.00002678971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000206373,0.00002965637,0.000210279,0.00003360706,0.00001187393,0.00003273492,0.00001053162,0.00005189882,0.997853,0.00004099619,0.00004398593,0.001475034],"study_design_scores_gemma":[0.00002227254,0.0003274895,0.0219727,0.000005227368,0.00002490772,0.0002868517,0.00006432131,0.0009818739,0.9736908,0.00006864738,0.002547976,0.000006889632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935918,0.002132869,0.001931124,0.0001180192,0.00003303957,0.00002898651,0.0006736442,0.00007935054,0.001411172],"genre_scores_gemma":[0.9939163,0.001032252,0.001373443,0.0001476791,0.000008286723,0.00004671903,0.000806756,0.00003028782,0.002638189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965956,"threshold_uncertainty_score":0.006576836,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2550348382","doi":"10.1182/blood.v106.11.2605.2605","title":"Stable Suppression of a Novel Oncogene, AHI-1, in Human Cutaneous T-Cell Leukemia Cells Normalizes Its Transforming Activity In Vitro and In Vivo and Aberrant Expression of AHI-1 Is Also Present in Leukemic Sezary Cells from Patients with Sezary Syndrome.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Biology; Autocrine signalling; Cell culture; Leukemia; Provirus; Gene knockdown; Molecular biology; RNA interference; Small hairpin RNA; Cancer research; Immunology; Gene; RNA; Genetics","authors":[{"name":"Ashley Ringrose","is_ca":true},{"name":"Youwen Zhou","is_ca":true},{"name":"Emily M. Pang","is_ca":true},{"name":"Ann Lin","is_ca":true},{"name":"Xiaojiang Li","is_ca":false},{"name":"Irene Li","is_ca":true},{"name":"Andrew P. Weng","is_ca":true},{"name":"Xiaoyan Jiang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005937374710615574,"gpt":0.2053744587937163,"spread":0.1994370840831008,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290849,0.0004481182,0.0002588412,0.0003034955,0.0001728085,0.0003235534,0.0001717233,0.0001931115,0.001976491],"category_scores_gemma":[0.0001152132,0.0001373193,0.0002282489,0.0002247474,0.0002333836,0.00009833777,0.0001280392,0.0005885434,0.0004449367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441336,"about_ca_system_score_gemma":0.0001838228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677782,"about_ca_topic_score_gemma":0.0009214033,"domain_scores_codex":[0.9998553,0.00001977555,0.00001684953,0.00003963646,0.00004089201,0.00002764391],"domain_scores_gemma":[0.9998724,0.00003004828,0.00003717218,0.00002313982,0.000009819043,0.0000273558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001721811,0.00001532319,0.00006162804,0.000005945712,0.000001504621,0.00001434347,0.000004816602,0.00001779148,0.9994991,0.00002134277,0.000009866882,0.0003310572],"study_design_scores_gemma":[0.000008891924,0.0002481526,0.001411916,0.000001894569,0.00001101443,0.0001649075,0.00001278368,0.0004844533,0.9968638,0.00000868649,0.0007815579,0.000001770175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942667,0.0005724411,0.003182093,0.00003735155,0.00002845662,0.0000616895,0.0005642952,0.000138129,0.001148867],"genre_scores_gemma":[0.9927744,0.0003867069,0.002919293,0.00001817744,0.000008374492,0.00005433597,0.001009659,0.00003656073,0.002792554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001976491,"threshold_uncertainty_score":0.006612003,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3015646212","doi":"10.1038/s41467-020-15290-0","title":"Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"SKiN Health","funders":"Congressionally Directed Medical Research Programs; National Center for Advancing Translational Sciences; Melanoma Research Alliance; National Cancer Institute; Yale University; U.S. Department of Health and Human Services; National Natural Science Foundation of China; U.S. Department of Defense","keywords":"Macrophage; Cancer research; Cancer; BRD4; Cancer cell; Chemistry; Cell biology; Bromodomain; Biology; Biochemistry; Genetics; Histone; DNA; In vitro","authors":[{"name":"Mingzhu Yin","is_ca":true},{"name":"Ying Guo","is_ca":false},{"name":"Rui Hu","is_ca":false},{"name":"Wesley L. Cai","is_ca":false},{"name":"Yao Li","is_ca":false},{"name":"Shiyao Pei","is_ca":false},{"name":"Hongyin Sun","is_ca":false},{"name":"Cong Peng","is_ca":false},{"name":"Jiali Li","is_ca":false},{"name":"Rui Ye","is_ca":false},{"name":"Qiaohong Yang","is_ca":false},{"name":"Nenghui Wang","is_ca":false},{"name":"Yongguang Tao","is_ca":false},{"name":"Xiang Chen","is_ca":true},{"name":"Qin Yan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01838858552513328,"gpt":0.3020018338926679,"spread":0.2836132483675347,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054365,0.0002109048,0.0002261321,0.0001804835,0.0001001111,0.0001285846,0.000181215,0.0001268478,0.000953504],"category_scores_gemma":[0.00004393041,0.00007708492,0.0001557983,0.0001287637,0.0001035196,0.0000827593,0.0001198777,0.0003314748,0.0003169559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535994,"about_ca_system_score_gemma":0.000244473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004156968,"about_ca_topic_score_gemma":0.001197094,"domain_scores_codex":[0.9999335,0.00001094022,0.000005132992,0.00000856161,0.00001993271,0.00002203149],"domain_scores_gemma":[0.9999791,0.000003214476,0.000004951919,0.000002285635,0.000003032425,0.000007361645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000224643,0.00009921895,0.0002290951,0.00007336887,0.000009779596,0.00004931092,0.000006074531,0.000111117,0.9949908,0.0001172693,0.000226314,0.003863006],"study_design_scores_gemma":[0.00008236364,0.000698445,0.003009984,0.000004278895,0.00001421764,0.0003015257,0.00001074722,0.00076811,0.9891558,0.00003648546,0.005915056,0.000002979477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851408,0.005726078,0.002936179,0.0002316539,0.00004684367,0.00005837878,0.0006460442,0.0001375256,0.005076467],"genre_scores_gemma":[0.9895014,0.00274409,0.002164717,0.0001139843,0.00001069748,0.00004253576,0.00139459,0.00001109868,0.004016926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000953504,"threshold_uncertainty_score":0.003189743,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1932584694","doi":"10.1161/circresaha.115.307004","title":"Bromodomain-Containing Protein 4","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":186,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Survivin; microRNA; BRD4; Downregulation and upregulation; Apoptosis; Cell cycle; Bromodomain; Cell growth; Chemistry; Cell biology; Epigenetics; Biology; Biochemistry; Gene","authors":[{"name":"Jolyane Meloche","is_ca":true},{"name":"François Potus","is_ca":true},{"name":"Mylène Vaillancourt","is_ca":true},{"name":"Alice Bourgeois","is_ca":true},{"name":"Ian Johnson","is_ca":true},{"name":"Laure Deschamps","is_ca":true},{"name":"Sophie Chabot","is_ca":true},{"name":"Grégoire Ruffenach","is_ca":true},{"name":"Sarah Henry","is_ca":true},{"name":"Sandra Breuils‐Bonnet","is_ca":true},{"name":"Ève Tremblay","is_ca":true},{"name":"Valérie Nadeau","is_ca":true},{"name":"Caroline Lambert","is_ca":true},{"name":"Renée Paradis","is_ca":true},{"name":"Steeve Provencher","is_ca":true},{"name":"Sébastien Bonnet","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1437878241753064,"gpt":0.3854728962561591,"spread":0.2416850720808527,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002558837,0.0003433617,0.000247435,0.0002175757,0.0002629599,0.0002925835,0.0004811385,0.0005139293,0.01032465],"category_scores_gemma":[0.0002818252,0.0001079939,0.0002610091,0.000160072,0.000374801,0.0001539718,0.0003580714,0.0005281239,0.003036272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339381,"about_ca_system_score_gemma":0.000274011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001996789,"about_ca_topic_score_gemma":0.0001863892,"domain_scores_codex":[0.9998047,0.0000398924,0.00001386598,0.00004768688,0.00005459059,0.0000393908],"domain_scores_gemma":[0.9998732,0.00002605908,0.00003031231,0.00001453347,0.00001239004,0.00004355496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002571199,0.0002942355,0.008541349,0.001199068,0.0000920574,0.001843344,0.00007527148,0.0005871982,0.8934671,0.007960685,0.01628303,0.06708539],"study_design_scores_gemma":[0.001083493,0.002976829,0.02699491,0.0001804075,0.0002093965,0.02226377,0.0001262014,0.002688765,0.5192165,0.003321056,0.4208862,0.00005232951],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8021508,0.05532796,0.03705055,0.008654998,0.002258238,0.0008817352,0.01563361,0.002206358,0.07583579],"genre_scores_gemma":[0.9478798,0.005584943,0.01074024,0.002064081,0.0002064517,0.0002711754,0.005328781,0.00005505881,0.02786942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01032465,"threshold_uncertainty_score":0.0345394,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1951559178","doi":"10.1016/j.molcel.2015.09.002","title":"EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling","year":2015,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Mental Health Research Canada; Hospital for Sick Children; University Health Network","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Biology; Epigenome; Epigenetics; Transcription factor; Cancer research; Epidermal growth factor receptor; Bromodomain; Carcinogenesis; Transcriptome; Enhancer; Genetics; Mutation; DNA methylation; Gene; Gene expression; Cancer","authors":[{"name":"Feng Liu","is_ca":false},{"name":"Gary C. Hon","is_ca":false},{"name":"Genaro R. Villa","is_ca":false},{"name":"Kristen M. Turner","is_ca":false},{"name":"Shiro Ikegami","is_ca":false},{"name":"Huijun Yang","is_ca":false},{"name":"Zhen Ye","is_ca":false},{"name":"Bin Li","is_ca":false},{"name":"Samantha Kuan","is_ca":false},{"name":"Ah Young Lee","is_ca":false},{"name":"Ciro Zanca","is_ca":false},{"name":"Bowen Wei","is_ca":false},{"name":"Greg Lucey","is_ca":false},{"name":"David Jenkins","is_ca":false},{"name":"Wei Zhang","is_ca":false},{"name":"Cathy L. Barr","is_ca":true},{"name":"Frank B. Furnari","is_ca":false},{"name":"Timothy F. Cloughesy","is_ca":false},{"name":"William H. Yong","is_ca":false},{"name":"Timothy C. Gahman","is_ca":false},{"name":"Andrew K. Shiau","is_ca":false},{"name":"Webster K. Cavenee","is_ca":false},{"name":"Bing Ren","is_ca":false},{"name":"Paul S. Mischel","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01643594838255873,"gpt":0.2331048341559888,"spread":0.2166688857734301,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009637047,0.0002127826,0.0001436189,0.0003388586,0.0001360122,0.0003268434,0.0001392257,0.0001630867,0.00138194],"category_scores_gemma":[0.0001140026,0.0001612073,0.0001892948,0.000158222,0.0001427078,0.0002434324,0.000183408,0.0003182543,0.0002385378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000399341,"about_ca_system_score_gemma":0.0001980539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146861,"about_ca_topic_score_gemma":0.002434809,"domain_scores_codex":[0.9999182,0.000009354771,0.000005801523,0.00001723522,0.00001853452,0.0000308513],"domain_scores_gemma":[0.999928,0.000006270049,0.00002882257,0.000008537836,0.000006853452,0.00002156336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003679624,0.00005746837,0.005913297,0.0000263263,0.00002574958,0.0003853048,0.00001618645,0.0002256065,0.9866551,0.0006971158,0.0003103799,0.005319514],"study_design_scores_gemma":[0.00003970598,0.0003254435,0.1191395,0.000008227328,0.00007853527,0.0023847,0.0001041954,0.003909121,0.8656331,0.0007654232,0.007601826,0.00001017832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935769,0.001878337,0.002124557,0.0001913123,0.00002353847,0.0000130733,0.000249677,0.0001234986,0.001819091],"genre_scores_gemma":[0.9979731,0.0004104158,0.0002978181,0.00003090862,0.000004579573,0.000006578643,0.000143361,0.000008920618,0.001124397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00138194,"threshold_uncertainty_score":0.004623055,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2100150541","doi":"10.1101/gad.223396.113","title":"Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity","year":2013,"lang":"en","type":"article","venue":"Genes & Development","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Compute Canada","keywords":"Biology; Histone acetyltransferase; Chromatin; Histone Acetyltransferases; Protein subunit; Acetyltransferase; Histone; Chromatin remodeling; Histone H4; Histone H1; Cell biology; Histone octamer; Histone H3; Genetics; Acetylation; Nucleosome; Gene","authors":[{"name":"Marie‐Eve Lalonde","is_ca":true},{"name":"Nikita Avvakumov","is_ca":true},{"name":"Karen C. Glass","is_ca":false},{"name":"France‐Hélène Joncas","is_ca":true},{"name":"Nehmé Saksouk","is_ca":true},{"name":"Michael Holliday","is_ca":false},{"name":"Éric R. Paquet","is_ca":true},{"name":"Kezhi Yan","is_ca":true},{"name":"Qiong Tong","is_ca":false},{"name":"Brianna J. Klein","is_ca":false},{"name":"Song Tan","is_ca":false},{"name":"Xiang‐Jiao Yang","is_ca":true},{"name":"Tatiana G. Kutateladze","is_ca":false},{"name":"Jacques Côté","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01438632752042767,"gpt":0.2347214120253747,"spread":0.220335084504947,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081129,0.0001930289,0.00009352312,0.00006831184,0.0001002377,0.000269692,0.0001528361,0.000142393,0.001178833],"category_scores_gemma":[0.0001641757,0.0001092192,0.00009444235,0.00006236645,0.0001608014,0.0001940484,0.0002180135,0.0002851439,0.0003821791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032728,"about_ca_system_score_gemma":0.0001177436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003641158,"about_ca_topic_score_gemma":0.0008790038,"domain_scores_codex":[0.9999113,0.00001061037,0.000005585381,0.00003141044,0.00002007808,0.00002107834],"domain_scores_gemma":[0.9999142,0.00002082079,0.00002231863,0.00001237024,0.000005902692,0.00002440876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004989031,0.00000594965,0.0002524428,0.000006065816,0.000001819894,0.00001900884,0.000006488404,0.00001731732,0.9987923,0.0001289427,0.00001453401,0.0007051919],"study_design_scores_gemma":[0.000009172396,0.00003734674,0.005982629,0.000002492558,0.000005670729,0.0001529312,0.00001827661,0.0009583833,0.9904442,0.00008719981,0.002298801,0.00000276734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959622,0.0004076716,0.002479217,0.00004100675,0.00001246971,0.000003760625,0.00007737616,0.00003815283,0.0009781973],"genre_scores_gemma":[0.9971138,0.0001401656,0.001002854,0.00002162946,0.000003911441,0.000003399593,0.0001795183,0.00002291094,0.001511747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178833,"threshold_uncertainty_score":0.003943563,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4364356934","doi":"10.1021/acscentsci.2c01317","title":"Rational Chemical Design of Molecular Glue Degraders","year":2023,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Mark Foundation For Cancer Research; Innovative Genomics Institute; Novartis Institutes for BioMedical Research; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Computational biology; Chemistry; Ubiquitin; Ubiquitin ligase; Covalent bond; Target protein; Proteasome; Protein degradation; Biochemistry; Combinatorial chemistry; Biology; Gene","authors":[{"name":"Ethan S. Toriki","is_ca":false},{"name":"James W. Papatzimas","is_ca":false},{"name":"Kaila Nishikawa","is_ca":false},{"name":"Dustin Dovala","is_ca":false},{"name":"Andreas O. Frank","is_ca":false},{"name":"Matthew J. Hesse","is_ca":false},{"name":"Daniela Danková","is_ca":false},{"name":"Jae-Geun Song","is_ca":false},{"name":"Megan Bruce-Smythe","is_ca":false},{"name":"Heidi Struble","is_ca":false},{"name":"F. García","is_ca":false},{"name":"Scott M. Brittain","is_ca":false},{"name":"Andrew C. Kile","is_ca":false},{"name":"Lynn M. McGregor","is_ca":false},{"name":"Jeffrey M. McKenna","is_ca":false},{"name":"John A. Tallarico","is_ca":false},{"name":"Markus Schirle","is_ca":false},{"name":"Daniel K. Nomura","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01631584461292817,"gpt":0.2541396342241705,"spread":0.2378237896112423,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004938431,0.0006037206,0.0002714068,0.0002945991,0.0001777651,0.0003250492,0.0004136013,0.000493832,0.0009017783],"category_scores_gemma":[0.000310593,0.0002409195,0.0003483041,0.0001996071,0.0002246163,0.0004027247,0.0003540315,0.0005883163,0.0006222273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004666961,"about_ca_system_score_gemma":0.0004024438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003519142,"about_ca_topic_score_gemma":0.0008577895,"domain_scores_codex":[0.999706,0.00004669049,0.00003195477,0.00005048937,0.0001020755,0.00006279766],"domain_scores_gemma":[0.999874,0.00001285617,0.00004485773,0.00001527454,0.00002794512,0.00002514127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002115038,0.0002327006,0.000270443,0.0005454461,0.00005194178,0.0004004715,0.0000915207,0.009393355,0.959417,0.008978824,0.0008111561,0.01959572],"study_design_scores_gemma":[0.0001154031,0.00140295,0.0002864193,0.00003016397,0.00002299097,0.000191665,0.00003150785,0.004977964,0.9642995,0.0007181166,0.02789389,0.00002937774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7966748,0.007591396,0.1667024,0.0009209663,0.0003472572,0.001303838,0.001113011,0.0008315946,0.0245149],"genre_scores_gemma":[0.9183694,0.007628901,0.066312,0.000285096,0.00003852828,0.0004049111,0.0006403096,0.00008591261,0.00623494],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0009017783,"threshold_uncertainty_score":0.00338608,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}