{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":931,"total_is_capped":false,"direct_labels_cover":1,"predictions_cover":931,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"8d472597082d","filters":{"topic":"Protein Tyrosine Phosphatases"}},"results":[{"id":"W1980740451","doi":"10.1016/j.cell.2007.05.047","title":"Endocrine Regulation of Energy Metabolism by the Skeleton","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2541,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Pennsylvania Department of Health; American Diabetes Association","keywords":"Biology; Osteocalcin; Endocrinology; Internal medicine; Glucose homeostasis; Insulin resistance; Bone remodeling; Insulin; Carbohydrate metabolism; Energy homeostasis; Adiponectin; Insulin receptor; Adipokine; Adipose tissue; Glucose uptake; Alkaline phosphatase; Biochemistry; Medicine; Obesity","authors":[{"name":"Na Kyung Lee","is_ca":false},{"name":"Hideaki Sowa","is_ca":false},{"name":"Eiichi Hinoi","is_ca":false},{"name":"Mathieu Ferron","is_ca":false},{"name":"Jong Deok Ahn","is_ca":false},{"name":"Cyrille B. Confavreux","is_ca":false},{"name":"Romain Dacquin","is_ca":false},{"name":"P. Joseph Mee","is_ca":false},{"name":"Marc D. McKee","is_ca":true},{"name":"Dae Young Jung","is_ca":false},{"name":"Zhiyou Zhang","is_ca":false},{"name":"Jason K. Kim","is_ca":false},{"name":"Franck Mauvais‐Jarvis","is_ca":false},{"name":"Patricia Ducy","is_ca":false},{"name":"Gérard Karsenty","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004007319868877987,"gpt":0.2127747066079078,"spread":0.2087673867390299,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522879,0.0003121027,0.0002049111,0.0004806128,0.000297718,0.0006405507,0.0002405438,0.0003200699,0.001725759],"category_scores_gemma":[0.0001654266,0.0002066602,0.0002307248,0.0003506127,0.0006053979,0.0005785159,0.0004809833,0.0005441116,0.0004300386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006158397,"about_ca_system_score_gemma":0.0003246397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408071,"about_ca_topic_score_gemma":0.003244919,"domain_scores_codex":[0.9999197,0.00001478393,0.000004123989,0.00001675146,0.00002312381,0.0000214515],"domain_scores_gemma":[0.9998969,0.00001880966,0.00002171242,0.00001191929,0.0000181244,0.00003256564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006429225,0.00003184523,0.001419407,0.0000988325,0.00002539764,0.0004604946,0.00004020428,0.000365316,0.9687833,0.009077055,0.0009299009,0.01812537],"study_design_scores_gemma":[0.0002305274,0.0004995402,0.06644095,0.00004602662,0.0000944196,0.002432964,0.0003336985,0.003806466,0.8668895,0.01104661,0.04812638,0.00005283449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8790359,0.06045317,0.02625441,0.003902463,0.0004367222,0.00004620549,0.0007953306,0.0002916306,0.02878416],"genre_scores_gemma":[0.9610922,0.01785376,0.004608047,0.0002004565,0.00008507425,0.00001708801,0.0003123795,0.00004736157,0.01578365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001725759,"threshold_uncertainty_score":0.005773246,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4210729786","doi":"10.1016/s0140-6736(12)61023-x","title":"Noonan syndrome","year":2013,"lang":"en","type":"review","venue":"The Lancet","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":769,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; European Commission","keywords":"Noonan syndrome; Short stature; Medicine; Disease; Pathophysiology; Heart disease; Bioinformatics; Pediatrics; Internal medicine; Biology","authors":[{"name":"Amy E. Roberts","is_ca":false},{"name":"Judith Allanson","is_ca":true},{"name":"Marco Tartaglia","is_ca":false},{"name":"Bruce D. Gelb","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05368501532697645,"gpt":0.3223023659680064,"spread":0.26861735064103,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004646883,0.001126599,0.001352556,0.001360555,0.0002970757,0.0008448787,0.0009533759,0.001685623,0.00411678],"category_scores_gemma":[0.001022098,0.0002298612,0.0003433949,0.000960594,0.0006646332,0.0008330295,0.0008033403,0.002698075,0.002197762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007358302,"about_ca_system_score_gemma":0.001046463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211328,"about_ca_topic_score_gemma":0.003042907,"domain_scores_codex":[0.9998038,0.00002874073,0.00001797865,0.00003210997,0.00009434173,0.00002297639],"domain_scores_gemma":[0.9998048,0.00008976954,0.00002319808,0.000007891968,0.00003603366,0.00003833131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001201344,0.000036342,0.0002028827,0.003237827,0.00008031513,0.002215306,0.00003033934,0.0002876268,0.001274836,0.005354789,0.2273208,0.7598388],"study_design_scores_gemma":[0.00005239479,0.00002145474,0.0004428733,0.00179018,0.00007933559,0.0066452,0.00002783523,0.00005706829,0.0002033505,0.002930466,0.9877337,0.00001621331],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001010935,0.9906674,0.0002399772,0.00218288,0.003051001,0.000003380805,0.00002395879,0.00001965719,0.003710647],"genre_scores_gemma":[0.001725992,0.9871699,0.0004275566,0.003150662,0.003555324,0.00000903827,0.00006910212,0.000005588447,0.003886813],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00411678,"threshold_uncertainty_score":0.01377195,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2143454794","doi":"10.1542/peds.2009-3207","title":"Noonan Syndrome: Clinical Features, Diagnosis, and Management Guidelines","year":2010,"lang":"en","type":"review","venue":"PEDIATRICS","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":619,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Novo Nordisk","keywords":"Noonan syndrome; Medicine; Short stature; Multidisciplinary approach; Disease; Deformity; Bioinformatics; Pediatrics; Intensive care medicine; Pathology; Internal medicine; Surgery","authors":[{"name":"Alicia Romanò","is_ca":false},{"name":"Judith Allanson","is_ca":true},{"name":"Jovanna Dahlgren","is_ca":false},{"name":"Bruce D. Gelb","is_ca":false},{"name":"Bryan D. Hall","is_ca":false},{"name":"Mary Ella Pierpont","is_ca":false},{"name":"Amy E. Roberts","is_ca":false},{"name":"Wanda Robinson","is_ca":false},{"name":"Clifford M. Takemoto","is_ca":false},{"name":"Jacqueline A. Noonan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06036347073880311,"gpt":0.3964795973441126,"spread":0.3361161266053095,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006263881,0.0009379914,0.001453074,0.002891513,0.0003237792,0.0007284248,0.001330136,0.001120264,0.002207698],"category_scores_gemma":[0.001327582,0.0002902588,0.0004232913,0.002257546,0.0004220218,0.001076147,0.0004704843,0.002211638,0.002290339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009619321,"about_ca_system_score_gemma":0.001749291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002549582,"about_ca_topic_score_gemma":0.005384027,"domain_scores_codex":[0.9996885,0.00006073897,0.00007514517,0.00003893627,0.0001159903,0.00002065629],"domain_scores_gemma":[0.9994999,0.0001737439,0.00008323145,0.000009781334,0.0001701705,0.00006313928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004638495,0.0001061458,0.0007745179,0.006266853,0.00004502769,0.001484408,0.00007031627,0.0004749914,0.0008238357,0.002238042,0.1812779,0.8063916],"study_design_scores_gemma":[0.00003097229,0.00003859865,0.00296625,0.009659454,0.0001122341,0.01440446,0.0001228174,0.0002219837,0.0002761583,0.002660594,0.9694793,0.00002708899],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003308579,0.9908555,0.0007418039,0.002860646,0.0007236839,0.00003821078,0.0001476957,0.00004122243,0.004260555],"genre_scores_gemma":[0.001739361,0.9919845,0.002339544,0.001145999,0.000570951,0.00005109303,0.0004032846,0.000006334248,0.001758901],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002891513,"threshold_uncertainty_score":0.007385492,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2070582535","doi":"10.1016/s1534-5807(02)00149-1","title":"Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B","year":2002,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":546,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada); SickKids Foundation; Hospital for Sick Children; McGill University","funders":"","keywords":"Leptin; Internal medicine; Endocrinology; Leptin receptor; Biology; Protein tyrosine phosphatase; Adipose tissue; Phosphorylation; Obesity; Phosphatase; Cell biology; Medicine","authors":[{"name":"Alan Cheng","is_ca":true},{"name":"Noriko Uetani","is_ca":true},{"name":"Paul D. Simoncic","is_ca":true},{"name":"Vikas P. Chaubey","is_ca":true},{"name":"Ailsa Lee-Loy","is_ca":true},{"name":"C. Jane McGlade","is_ca":true},{"name":"Brian P. Kennedy","is_ca":true},{"name":"Michel L. Tremblay","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01286746777186747,"gpt":0.2121460070077151,"spread":0.1992785392358477,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003046232,0.0005049589,0.0003933196,0.0004422773,0.0003055607,0.0005923564,0.0003987894,0.0003318868,0.001555388],"category_scores_gemma":[0.0004171137,0.0004025888,0.0003301332,0.000220469,0.0007415211,0.0004149946,0.0003791835,0.001206036,0.0003444391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006374306,"about_ca_system_score_gemma":0.00053645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00131189,"about_ca_topic_score_gemma":0.001853171,"domain_scores_codex":[0.9997935,0.00004160586,0.00001549506,0.00002754276,0.00003579443,0.00008620278],"domain_scores_gemma":[0.999826,0.00003214666,0.00003914739,0.00002176061,0.00001864869,0.00006243589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00352408,0.0001308703,0.0003336241,0.00005808719,0.00001338119,0.0001571639,0.00002763772,0.000153201,0.9908992,0.001039613,0.0001703502,0.00349286],"study_design_scores_gemma":[0.0003638989,0.0007641484,0.00729463,0.00001072438,0.00003421326,0.0003187612,0.00009597616,0.001967727,0.9845761,0.0004979023,0.004063325,0.00001273477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987107,0.006744863,0.003023984,0.000796117,0.0001742534,0.00003068015,0.0003295337,0.000133298,0.001660214],"genre_scores_gemma":[0.9897931,0.003414565,0.002114743,0.000113207,0.00004550319,0.00007406352,0.0004130025,0.00005394904,0.003977868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555388,"threshold_uncertainty_score":0.005203247,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2135086805","doi":"10.1124/pr.107.00106","title":"Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer","year":2008,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":541,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Dual-specificity phosphatase; Protein kinase A; MAPK/ERK pathway; Protein tyrosine phosphatase; Biology; Mitogen-activated protein kinase; Phosphatase; Kinase; Cell biology; Cancer; DUSP6; Cancer research; Protein phosphatase 2; Phosphorylation; Genetics","authors":[{"name":"Tarek Boutros","is_ca":true},{"name":"Éric Chevet","is_ca":true},{"name":"Peter Metrakos","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05488834551514027,"gpt":0.3499268237819086,"spread":0.2950384782667683,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005521625,0.001417173,0.001503448,0.001376033,0.0003433301,0.001026324,0.001362265,0.001044651,0.003466889],"category_scores_gemma":[0.0004308868,0.0003306955,0.0003330075,0.002539132,0.0007016684,0.001325924,0.000641292,0.001951463,0.003991216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007320745,"about_ca_system_score_gemma":0.0009791147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008708054,"about_ca_topic_score_gemma":0.002141462,"domain_scores_codex":[0.9998465,0.00001677046,0.00001703363,0.00002766318,0.00007437628,0.00001766691],"domain_scores_gemma":[0.9997973,0.00005990016,0.00002985641,0.000008265366,0.0000671351,0.00003755946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001326743,0.00009956954,0.0001177777,0.006873303,0.00006982526,0.0002401449,0.00003295715,0.0003545666,0.007470177,0.004157861,0.06918971,0.9112616],"study_design_scores_gemma":[0.0000437633,0.0000621865,0.0006000712,0.0006168561,0.00007537939,0.001182455,0.00004372955,0.0001149625,0.001344314,0.00235007,0.9935489,0.00001742817],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001655437,0.9966258,0.0005116183,0.0003420845,0.0005169681,0.000008838202,0.00002436388,0.0000231294,0.001781774],"genre_scores_gemma":[0.0007764276,0.9967619,0.0005078421,0.0002162028,0.0003181863,0.00001235388,0.00003706961,0.000002285729,0.001367631],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003466889,"threshold_uncertainty_score":0.01159793,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2011398963","doi":"10.1038/nrc2980","title":"Inside the human cancer tyrosine phosphatome","year":2010,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":507,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Protein tyrosine phosphatase; Suppressor; Biology; Receptor tyrosine kinase; Phosphorylation; Kinase; Phosphatase; Function (biology); Tyrosine kinase; Tyrosine; Tyrosine phosphorylation; Cell biology; Cancer; Signal transduction; Cancer research; Biochemistry; Genetics","authors":[{"name":"Sofi G. Julien","is_ca":true},{"name":"Nadia Dubé","is_ca":true},{"name":"Serge Hardy","is_ca":true},{"name":"Michel L. Tremblay","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03005890976887699,"gpt":0.3906701765316548,"spread":0.3606112667627778,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000559231,0.001339493,0.00146768,0.001155772,0.0003480611,0.001337893,0.001036245,0.002072956,0.002789475],"category_scores_gemma":[0.000501423,0.0004537325,0.0004298487,0.001802985,0.0009596523,0.001968821,0.001241746,0.00349954,0.003843384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009943865,"about_ca_system_score_gemma":0.001051453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001181445,"about_ca_topic_score_gemma":0.002156351,"domain_scores_codex":[0.9997713,0.00003979425,0.00002172827,0.00003673416,0.00009574672,0.00003484438],"domain_scores_gemma":[0.9998353,0.00005390754,0.00002381487,0.000009777573,0.00004660773,0.00003062795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001585858,0.00005637405,0.0001542023,0.005421459,0.00006008122,0.0004449939,0.00005206603,0.0005540447,0.00642179,0.009824354,0.1070112,0.8698408],"study_design_scores_gemma":[0.00001445886,0.00002060572,0.0001509246,0.0002832863,0.00002450406,0.0005996426,0.00001306498,0.00005518974,0.0006709206,0.00169409,0.996466,0.000007189807],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001157989,0.9967661,0.0002948145,0.000772257,0.0006252261,0.000003373691,0.00001953725,0.00001507811,0.00138784],"genre_scores_gemma":[0.001458826,0.9937977,0.0003104017,0.0008618734,0.0006735365,0.000009236179,0.00005723119,0.000003928705,0.002827198],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002789475,"threshold_uncertainty_score":0.009331703,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2049360086","doi":"10.1038/sj.onc.1203923","title":"Selected glimpses into the activation and function of Src kinase","year":2000,"lang":"en","type":"review","venue":"Oncogene","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":413,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Biology; Cell biology; Endosome; Protein tyrosine phosphatase; Tyrosine-protein kinase CSK; SH3 domain; Tyrosine kinase; Subcellular localization; Kinase; Receptor tyrosine kinase; Signal transduction; Cytoplasm","authors":[{"name":"Jeffrey D. Bjorge","is_ca":true},{"name":"Andrew Jakymiw","is_ca":true},{"name":"Donald J. Fujita","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01525251854127042,"gpt":0.2806128216633311,"spread":0.2653603031220607,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007984643,0.001500375,0.001462336,0.001811094,0.0003239722,0.001155052,0.001419019,0.001391881,0.001757022],"category_scores_gemma":[0.0006970071,0.0005044581,0.000394616,0.002402908,0.001346665,0.002210752,0.0009471893,0.003246306,0.002084063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001238766,"about_ca_system_score_gemma":0.0007775601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007790809,"about_ca_topic_score_gemma":0.001539618,"domain_scores_codex":[0.9997906,0.00002448737,0.00002826447,0.00004956808,0.0000800487,0.00002702879],"domain_scores_gemma":[0.9997354,0.00009495084,0.00002901166,0.00001655935,0.00007949208,0.00004462879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005033858,0.0001413093,0.0002652382,0.008060756,0.0001287815,0.00131353,0.000145257,0.001216338,0.02958416,0.0156267,0.08141271,0.8616018],"study_design_scores_gemma":[0.00006545825,0.00009839182,0.0005540077,0.0005948903,0.00007259865,0.001941564,0.00005045965,0.0001437807,0.006251297,0.003733454,0.9864731,0.00002097946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005607664,0.9942062,0.001009241,0.000686935,0.00137695,0.000009153829,0.00002599864,0.00002054303,0.00210425],"genre_scores_gemma":[0.002295555,0.9894832,0.001000041,0.0009780149,0.001705615,0.00001661011,0.00009453372,0.000007792109,0.004418655],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001811094,"threshold_uncertainty_score":0.008987904,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2033406586","doi":"10.1016/s0962-8924(01)02154-7","title":"SH2 domains, interaction modules and cellular wiring","year":2001,"lang":"en","type":"review","venue":"Trends in Cell Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":406,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Protein–protein interaction; Cell biology; Nucleic acid; Mutant; SH2 domain; Cell; Computational biology; Cell signaling; Signal transduction; Genetics; Gene; Protein tyrosine phosphatase","authors":[{"name":"Tony Pawson","is_ca":true},{"name":"Gerald Gish","is_ca":true},{"name":"Piers Nash","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03181912746522656,"gpt":0.3273741349055216,"spread":0.295555007440295,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004892848,0.0009822587,0.001393271,0.0008235466,0.0003732001,0.001428943,0.001470982,0.001401553,0.002458538],"category_scores_gemma":[0.0002757735,0.0004015605,0.0002391937,0.001536653,0.0009706343,0.00182501,0.0006247003,0.001470961,0.002104181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006393288,"about_ca_system_score_gemma":0.0004457877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007307787,"about_ca_topic_score_gemma":0.001365188,"domain_scores_codex":[0.9998833,0.00001134685,0.00001020222,0.00003181714,0.00004406118,0.00001922073],"domain_scores_gemma":[0.9999108,0.00003668369,0.00001438877,0.000005288316,0.0000183319,0.00001439818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003173108,0.00007287566,0.000619212,0.006326102,0.0001044051,0.0008295137,0.0001234849,0.001354993,0.03574632,0.01928036,0.0290356,0.9061898],"study_design_scores_gemma":[0.00004717914,0.00005986141,0.002081429,0.0004930031,0.000100328,0.002385779,0.0001247361,0.0004942779,0.006319315,0.01308029,0.9747866,0.0000271697],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001922869,0.9917632,0.001673699,0.0005165507,0.0003872802,0.000006839563,0.00004847153,0.00003809635,0.003643029],"genre_scores_gemma":[0.007687674,0.9842866,0.001129096,0.0005357731,0.000572147,0.00002302311,0.0001669691,0.000005245561,0.005593465],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002458538,"threshold_uncertainty_score":0.008224666,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1970469339","doi":"10.1038/nchembio.1528","title":"Targeting the disordered C terminus of PTP1B with an allosteric inhibitor","year":2014,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":383,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Allosteric regulation; Small molecule; Carcinogenesis; Binding site; Chemistry; Drug discovery; Cancer research; Cell biology; Computational biology; Biology; Biochemistry; Receptor; Gene","authors":[{"name":"Navasona Krishnan","is_ca":false},{"name":"Dorothy Koveal","is_ca":false},{"name":"Daniel Miller","is_ca":false},{"name":"Bin Xue","is_ca":false},{"name":"S. Dipikaa Akshinthala","is_ca":false},{"name":"Jaka Kragelj","is_ca":false},{"name":"Malene Ringkjøbing Jensen","is_ca":false},{"name":"Carla‐Maria Gauss","is_ca":false},{"name":"Rebecca Page","is_ca":false},{"name":"Martin Blackledge","is_ca":false},{"name":"Senthil K. Muthuswamy","is_ca":true},{"name":"Wolfgang Peti","is_ca":false},{"name":"Nicholas K. Tonks","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003279015804172804,"gpt":0.2316465185156203,"spread":0.2283675027114475,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002846493,0.0002673179,0.0002713064,0.0001261802,0.0002278349,0.0003902518,0.0005364004,0.0003756685,0.001360074],"category_scores_gemma":[0.0002319676,0.0001897465,0.0002288804,0.0001276179,0.0003072681,0.0002011455,0.0002806481,0.0009282943,0.000479905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008538048,"about_ca_system_score_gemma":0.0003781435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209276,"about_ca_topic_score_gemma":0.001748105,"domain_scores_codex":[0.9998242,0.0000197694,0.00001352423,0.00004107404,0.00005955902,0.00004192859],"domain_scores_gemma":[0.9999193,0.00001622322,0.00002162161,0.00000897731,0.000008696968,0.00002517228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002111019,0.0000508447,0.0001304841,0.00004428794,0.000009121231,0.00008099213,0.00001630091,0.0004870645,0.995906,0.0007207991,0.000210153,0.002132767],"study_design_scores_gemma":[0.00009227142,0.0001220237,0.0004715899,0.000006341029,0.00001895247,0.0003121267,0.00001153207,0.004668043,0.9903595,0.00009857074,0.003827967,0.00001090121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786155,0.001440021,0.01428298,0.0005232745,0.0001398263,0.00009419172,0.0002426241,0.0002436955,0.004417778],"genre_scores_gemma":[0.9921773,0.0005355409,0.004694754,0.0001356064,0.00001402983,0.00003668225,0.0001715105,0.0000307292,0.002203907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001360074,"threshold_uncertainty_score":0.00619483,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2061122212","doi":"10.1007/s10555-008-9126-y","title":"The tyrosine phosphatase Shp2 (PTPN11) in cancer","year":2008,"lang":"en","type":"review","venue":"Cancer and Metastasis Reviews","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":381,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"PTPN11; Protein tyrosine phosphatase; Juvenile myelomonocytic leukemia; Cancer research; Biology; Proto-oncogene tyrosine-protein kinase Src; Noonan syndrome; Phosphorylation; Phosphatase; Cancer; Oncogene; Receptor tyrosine kinase; Tyrosine phosphorylation; Mutation; Genetics; Gene; Cell cycle; KRAS","authors":[{"name":"Gordon Chan","is_ca":true},{"name":"Demetrios Kalaitzidis","is_ca":false},{"name":"Benjamin G. Neel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06822006417607326,"gpt":0.3793863017769613,"spread":0.311166237600888,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007438308,0.001177217,0.001491592,0.00118148,0.0003282687,0.0009630091,0.001182455,0.001482655,0.003026699],"category_scores_gemma":[0.00069756,0.0003691041,0.0003763192,0.002032857,0.0006419861,0.001455532,0.0008125319,0.002255297,0.002749673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008283475,"about_ca_system_score_gemma":0.001024065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009726667,"about_ca_topic_score_gemma":0.001769037,"domain_scores_codex":[0.9997934,0.00002520245,0.00002142381,0.00003249185,0.0001051235,0.00002239736],"domain_scores_gemma":[0.9997686,0.00007868164,0.00003172641,0.000007959586,0.00007622131,0.00003683271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001123903,0.00005880924,0.0001542242,0.006505273,0.00007576777,0.0003062007,0.00003381439,0.0006464573,0.004090578,0.004670226,0.09911358,0.8842326],"study_design_scores_gemma":[0.00003154221,0.00004767585,0.0003791988,0.0006082029,0.00006811143,0.0009585051,0.00002332823,0.0001177069,0.0005933173,0.001930951,0.9952304,0.00001097821],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009393883,0.9976106,0.0003278978,0.0003292819,0.0006973462,0.000004049595,0.00001038452,0.00001172849,0.0009148513],"genre_scores_gemma":[0.0006168067,0.9969036,0.0003054416,0.000226168,0.0005194987,0.000007174563,0.00002677357,0.00000164927,0.00139286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003026699,"threshold_uncertainty_score":0.01012528,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2104599144","doi":"10.1038/ng.641","title":"Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia","year":2010,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":373,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; University of California, San Francisco","keywords":"Juvenile myelomonocytic leukemia; Biology; Germline; Neurofibromatosis; Neurofibromin 1; Germline mutation; Costello syndrome; Missense mutation; Noonan syndrome; Genetics; PTPN11; Ubiquitin ligase; Cancer research; Mutation; Internal medicine; Endocrinology; Ubiquitin; KRAS; Haematopoiesis; Stem cell; Medicine","authors":[{"name":"Charlotte M. Niemeyer","is_ca":false},{"name":"Michelle Kang","is_ca":false},{"name":"Danielle H. Shin","is_ca":false},{"name":"Ingrid Furlan","is_ca":false},{"name":"Miriam Erlacher","is_ca":false},{"name":"Nancy Bunin","is_ca":false},{"name":"Severa Bunda","is_ca":true},{"name":"Jerry Z. Finklestein","is_ca":false},{"name":"Kathleen M. Sakamoto","is_ca":false},{"name":"Thomas A. Gorr","is_ca":false},{"name":"Parinda A. Mehta","is_ca":false},{"name":"Irene Schmid","is_ca":false},{"name":"Gabriele Kropshofer","is_ca":false},{"name":"Selim Corbacioglu","is_ca":false},{"name":"Peter Lang","is_ca":false},{"name":"Christoph Klein","is_ca":false},{"name":"Paul-Gerhard Schlegel","is_ca":false},{"name":"Andrea Heinzmann","is_ca":false},{"name":"Michaela Schneider","is_ca":false},{"name":"Jan Starý","is_ca":false},{"name":"Marry M. van den Heuvel‐Eibrink","is_ca":false},{"name":"Henrik Hasle","is_ca":false},{"name":"Franco Locatelli","is_ca":false},{"name":"Debbie S. Sakai","is_ca":false},{"name":"Sophie Archambeault","is_ca":false},{"name":"Leslie Chen","is_ca":false},{"name":"Ryan C. Russell","is_ca":true},{"name":"Stephanie S. Sybingco","is_ca":true},{"name":"Michael Ohh","is_ca":true},{"name":"Benjamin S. Braun","is_ca":false},{"name":"Christian Flotho","is_ca":false},{"name":"Mignon L. Loh","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006363565518400894,"gpt":0.2557953281022911,"spread":0.2494317625838902,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178184,0.001145376,0.0004119747,0.002018066,0.0007967,0.0005126211,0.0005433502,0.001103643,0.00321074],"category_scores_gemma":[0.0009715752,0.0003997897,0.0002970845,0.0008380744,0.001106163,0.0002330076,0.00077208,0.0008758507,0.000389016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006256522,"about_ca_system_score_gemma":0.0004465097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003077654,"about_ca_topic_score_gemma":0.004296321,"domain_scores_codex":[0.999665,0.00004106891,0.00003576936,0.00005894621,0.000120768,0.00007845591],"domain_scores_gemma":[0.9990423,0.0003332917,0.0003064217,0.00003795996,0.00003956263,0.0002404462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00119698,0.0001528509,0.06150362,0.0001380906,0.00009104819,0.4111995,0.0006760557,0.0008287225,0.5104795,0.002073629,0.001037382,0.01062272],"study_design_scores_gemma":[0.0002693424,0.000353292,0.2933759,0.00006398102,0.0002679947,0.59106,0.0008680378,0.002506821,0.1029199,0.00152086,0.006679987,0.0001138962],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996204,0.0003343409,0.0007175116,0.0002193301,0.00003028645,0.00002117071,0.0001932507,0.0001048421,0.002175433],"genre_scores_gemma":[0.9987115,0.0001351687,0.0004571786,0.00004111163,0.00002399123,0.000005170245,0.00005256688,0.00002280802,0.0005503775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00321074,"threshold_uncertainty_score":0.01074106,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2079933835","doi":"10.1038/nrm2126","title":"Emerging roles of nuclear protein phosphatases","year":2007,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":364,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Wellcome Trust","keywords":"Phosphatase; Biology; Cell biology; Nuclear protein; Protein phosphorylation; Phosphorylation; Nuclear transport; Transcription factor; Cell nucleus; Biochemistry; Protein kinase A; Gene; Nucleus","authors":[{"name":"Greg B. G. Moorhead","is_ca":true},{"name":"Laura Trinkle‐Mulcahy","is_ca":false},{"name":"Annegret Ulke‐Lemée","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01603706300091293,"gpt":0.326589092962394,"spread":0.3105520299614811,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001514552,0.001234318,0.00174983,0.001315897,0.0003647149,0.001937247,0.001781632,0.001773783,0.001811312],"category_scores_gemma":[0.0008958922,0.0004471428,0.00037571,0.001797426,0.001841974,0.002774487,0.001369481,0.003327987,0.001549907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001209375,"about_ca_system_score_gemma":0.001386914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008726224,"about_ca_topic_score_gemma":0.002038246,"domain_scores_codex":[0.9997173,0.00003851093,0.00003256827,0.00005495411,0.0001247391,0.00003193789],"domain_scores_gemma":[0.9995172,0.0002009437,0.00004230901,0.00002061896,0.0001526815,0.00006628631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002001915,0.00005714853,0.0002594733,0.006853312,0.00009692843,0.0006601821,0.0000947849,0.0009997956,0.009083662,0.02177755,0.05850232,0.9014148],"study_design_scores_gemma":[0.00003204255,0.00002526443,0.0002904167,0.0005092196,0.00005138062,0.0009884946,0.00006100704,0.0001359578,0.0009754105,0.005728341,0.991187,0.000015452],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001657855,0.9968516,0.0004717807,0.0008554483,0.0006650809,0.00000245397,0.00000983902,0.00001254823,0.000965464],"genre_scores_gemma":[0.0008466343,0.9968073,0.0003865205,0.000537087,0.0005551915,0.000005146524,0.00002060668,0.000001962297,0.0008396753],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001937247,"threshold_uncertainty_score":0.008774698,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1982603741","doi":"10.1016/s0960-9822(02)00697-8","title":"The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3","year":2002,"lang":"en","type":"article","venue":"Current Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":351,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; McGill University; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Biology; Protein tyrosine phosphatase; Regulator; Protein-Serine-Threonine Kinases; Kinase; Phosphatase; Janus; Negative regulator; Cell biology; Janus kinase; Tyrosine kinase; Protein-Tyrosine Kinases; Tyrosine; Signalling; Phosphorylation; Biochemistry; Protein kinase A; Signal transduction; Gene","authors":[{"name":"Paul D. Simoncic","is_ca":true},{"name":"Ailsa Lee-Loy","is_ca":true},{"name":"Dwayne L. Barber","is_ca":true},{"name":"Michel L. Tremblay","is_ca":true},{"name":"C. Jane McGlade","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.018221172741957,"gpt":0.2514402858199607,"spread":0.2332191130780037,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001795129,0.0004936998,0.0002862105,0.0002538021,0.0003870121,0.0006989258,0.0002745183,0.0002677349,0.0007690316],"category_scores_gemma":[0.0002225101,0.0001619874,0.0002360257,0.0001470192,0.0003518793,0.0002804392,0.00033057,0.0006123701,0.0005683191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003894299,"about_ca_system_score_gemma":0.0002898042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003598004,"about_ca_topic_score_gemma":0.0004909482,"domain_scores_codex":[0.9998574,0.00001615312,0.000008766585,0.00003206955,0.00004940786,0.00003606932],"domain_scores_gemma":[0.999905,0.00001148871,0.00002487194,0.000005389287,0.00001759654,0.0000356052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002865685,0.00002100926,0.0006980366,0.0001018103,0.0000119137,0.0004138916,0.00002300701,0.0001688236,0.9873611,0.001542481,0.0007317908,0.008639642],"study_design_scores_gemma":[0.0000732508,0.0002526404,0.008271037,0.00001490529,0.00004846951,0.002692613,0.00006393723,0.002607634,0.9617038,0.001491018,0.02276517,0.00001541197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.91249,0.05282285,0.01785781,0.001276668,0.001040665,0.0001161127,0.0005393544,0.0003532753,0.01350325],"genre_scores_gemma":[0.9806138,0.009809504,0.002613568,0.0001918907,0.0002460729,0.00004361493,0.0005113774,0.00003037706,0.00593979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007690316,"threshold_uncertainty_score":0.002825499,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2057358596","doi":"10.1016/j.cell.2010.08.023","title":"Phosphotyrosine Signaling: Evolving a New Cellular Communication System","year":2010,"lang":"en","type":"article","venue":"Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":347,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Eye Institute; Howard Hughes Medical Institute","keywords":"Biology; SH2 domain; Proto-oncogene tyrosine-protein kinase Src; Phosphorylation; Protein tyrosine phosphatase; Signal transduction; Cell biology; Tyrosine phosphorylation; Tyrosine; Kinase; Receptor tyrosine kinase; Cell signaling; Homology (biology); Tyrosine kinase; Computational biology; Genetics; Biochemistry; Gene","authors":[{"name":"Wendell A. Lim","is_ca":false},{"name":"Tony Pawson","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006542311322408689,"gpt":0.2099112807256839,"spread":0.2033689694032752,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00155523,0.0005318941,0.0007385158,0.0007282211,0.0008543928,0.003840336,0.001304644,0.001542236,0.002727194],"category_scores_gemma":[0.001137815,0.0003131683,0.0003599696,0.0004899596,0.002864868,0.007310522,0.001625945,0.002539342,0.001223196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001339655,"about_ca_system_score_gemma":0.001245249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003662483,"about_ca_topic_score_gemma":0.0004488923,"domain_scores_codex":[0.9996341,0.00006480915,0.00002320461,0.00008935231,0.000120543,0.00006779412],"domain_scores_gemma":[0.9993906,0.0001599457,0.00005695175,0.00009455183,0.0001416589,0.0001562653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004644608,0.0001804282,0.001512484,0.0003377658,0.00006822753,0.0005282181,0.0006855212,0.002648479,0.3415445,0.4950041,0.008374718,0.148651],"study_design_scores_gemma":[0.0001609765,0.0007993701,0.002463681,0.0002668058,0.0002073031,0.002328641,0.00116654,0.0233196,0.2442019,0.3813962,0.3435247,0.0001642812],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.3722874,0.0923451,0.4144418,0.05704358,0.00616711,0.0001168682,0.0005322493,0.002294114,0.05477169],"genre_scores_gemma":[0.811231,0.05011078,0.1101975,0.005813906,0.003061064,0.0001759135,0.0004217311,0.0002362124,0.01875195],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003840336,"threshold_uncertainty_score":0.009719968,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2099220382","doi":"10.1038/ng1963","title":"Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis","year":2007,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":320,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Royal Victoria Hospital; McGill University; Royal Victoria Regional Health Centre; Merck Canada Inc. (Canada); McGill University Health Centre","funders":"","keywords":"Biology; Carcinogenesis; Cancer research; Metastasis; Protein tyrosine phosphatase; Mammary gland; Protein kinase B; Genetically modified mouse; Mammary tumor; MAPK/ERK pathway; Receptor tyrosine kinase; Transgene; Breast cancer; Cancer; Signal transduction; Cell biology; Genetics; Gene","authors":[{"name":"Sofi G. Julien","is_ca":true},{"name":"Nadia Dubé","is_ca":true},{"name":"Michelle Read","is_ca":true},{"name":"Janice Penney","is_ca":true},{"name":"Marilène Paquet","is_ca":true},{"name":"Yongxin Han","is_ca":true},{"name":"Brian P. Kennedy","is_ca":true},{"name":"William J. Muller","is_ca":true},{"name":"Michel L. Tremblay","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009424190743949783,"gpt":0.2575251356767723,"spread":0.2481009449328225,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000243282,0.0008381723,0.0007187798,0.0008446303,0.0003357644,0.000688466,0.0007611344,0.0006218019,0.003964776],"category_scores_gemma":[0.0002351535,0.0006597938,0.0004784696,0.000375904,0.0005649474,0.0005507024,0.0003709278,0.002054297,0.0009928874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007486918,"about_ca_system_score_gemma":0.0007678955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002438146,"about_ca_topic_score_gemma":0.003317415,"domain_scores_codex":[0.9997172,0.00003315154,0.0000212215,0.00005438696,0.00006483567,0.0001092313],"domain_scores_gemma":[0.9995666,0.00006348252,0.0001083425,0.00005691763,0.00002289042,0.0001817954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007294471,0.0001222946,0.0001568656,0.00002787421,0.00001247455,0.00005878866,0.000009927989,0.0001246994,0.9968736,0.0002776306,0.0001869107,0.001419643],"study_design_scores_gemma":[0.0001146316,0.0007236383,0.002619105,0.00000781473,0.00002974472,0.0003268936,0.0000417599,0.0009930725,0.9926406,0.0001518909,0.002339935,0.00001093843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882354,0.003111878,0.003188237,0.0005849083,0.0002483677,0.00004473238,0.001327889,0.000654813,0.002603887],"genre_scores_gemma":[0.9870518,0.001264815,0.001226541,0.00009269663,0.00003112348,0.00005218439,0.0009996672,0.0001189361,0.009162109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003964776,"threshold_uncertainty_score":0.01326352,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2140982760","doi":"10.1126/science.1200840","title":"Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":318,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council; Cancer Research UK; National Institutes of Health; McGill University; Diamond Light Source; National Eye Institute; Wellcome Trust","keywords":"Extension (predicate logic); Proteoglycan; Cluster analysis; Computational biology; Cell biology; Mechanism (biology); Biology; Computer science; Neuroscience; Artificial intelligence; Physics","authors":[{"name":"C.H. Coles","is_ca":false},{"name":"Yingjie Shen","is_ca":false},{"name":"Alan P. Tenney","is_ca":false},{"name":"Christian Siebold","is_ca":false},{"name":"Geoffrey C. Sutton","is_ca":false},{"name":"Weixian Lu","is_ca":false},{"name":"John T. Gallagher","is_ca":false},{"name":"E. Yvonne Jones","is_ca":false},{"name":"John G. Flanagan","is_ca":false},{"name":"A.R. Aricescu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02758301038533082,"gpt":0.2528079215494186,"spread":0.2252249111640877,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008659447,0.0001748082,0.0001516362,0.00009651826,0.0001203531,0.0003064341,0.0001698115,0.0001974993,0.001393338],"category_scores_gemma":[0.0001010223,0.0001382363,0.0001657288,0.00007894584,0.0002208019,0.0001860368,0.0003171464,0.0004038259,0.0004204333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003743049,"about_ca_system_score_gemma":0.0001856312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003122875,"about_ca_topic_score_gemma":0.0007999082,"domain_scores_codex":[0.9999138,0.000008388045,0.000004501412,0.00002186453,0.00002429164,0.00002710562],"domain_scores_gemma":[0.9999294,0.00001082584,0.00001423392,0.00001042731,0.000007216792,0.00002783915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002087581,0.000004760924,0.00003536445,0.000006659463,9.652259e-7,0.00002742185,0.000004288067,0.00001341634,0.9993947,0.0001267712,0.00001504624,0.000349799],"study_design_scores_gemma":[0.000009115123,0.00005207069,0.004206226,0.000003983926,0.000003541607,0.000163975,0.00002255924,0.0006627,0.9938204,0.00008181322,0.0009701371,0.000003534696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949468,0.0006240707,0.001972947,0.00006193485,0.00001898107,0.00001236298,0.00006651854,0.00005382656,0.002242625],"genre_scores_gemma":[0.9969863,0.0002341719,0.0009401098,0.00004152499,0.000005813968,0.00001739482,0.0001077949,0.00001435222,0.001652535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393338,"threshold_uncertainty_score":0.004661202,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2042122259","doi":"10.1006/smim.2000.0223","title":"Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling","year":2000,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; Arthritis Society","keywords":"Protein tyrosine phosphatase; Cell biology; Signalling; Tyrosine; Phosphatase; Biology; Signal transduction; Extracellular; Cell; Autoimmunity; Cell signaling; SH2 domain; Chemistry; Phosphorylation; Biochemistry; Immunology; Immune system","authors":[{"name":"Jinyi Zhang","is_ca":false},{"name":"Ally-Khan Somani","is_ca":true},{"name":"Katherine A. Siminovitch","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01214704219211182,"gpt":0.2639155392286022,"spread":0.2517684970364904,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009724008,0.001273515,0.001541573,0.001052255,0.0003774848,0.001283958,0.001731059,0.001625017,0.002001117],"category_scores_gemma":[0.0005423757,0.0003225229,0.0003419316,0.001246951,0.001176289,0.001777944,0.0008420295,0.002405585,0.002276622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001014267,"about_ca_system_score_gemma":0.0007636201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006144295,"about_ca_topic_score_gemma":0.0008230064,"domain_scores_codex":[0.9998239,0.00002303798,0.00002089035,0.00003754831,0.00006827418,0.00002643368],"domain_scores_gemma":[0.9997303,0.00010025,0.00002916364,0.00001247089,0.00007674647,0.00005097787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003922203,0.00009554479,0.000310819,0.007056671,0.0001084469,0.001113588,0.00006981013,0.001054615,0.01653777,0.01338468,0.05162453,0.9082515],"study_design_scores_gemma":[0.00007207712,0.0000980491,0.0009459197,0.0005553825,0.0001033266,0.002620177,0.00007612557,0.0003240028,0.004400861,0.007306629,0.9834711,0.00002635266],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005258641,0.994451,0.0008270629,0.0008058398,0.00138048,0.000005992554,0.00001855601,0.00002004653,0.001965069],"genre_scores_gemma":[0.003436349,0.9920475,0.000486878,0.0004520182,0.001296824,0.0000117447,0.00004495667,0.000003086682,0.002220727],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002001117,"threshold_uncertainty_score":0.007359028,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2005076200","doi":"10.1074/jbc.m004852200","title":"Identification of Protein-tyrosine Phosphatase 1B as the Major Tyrosine Phosphatase Activity Capable of Dephosphorylating and Activating c-Src in Several Human Breast Cancer Cell Lines","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":311,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"National Cancer Institute; Medical Research Council; Medical Research Council Canada","keywords":"Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; Phosphatase; Tyrosine kinase; Tyrosine-protein kinase CSK; Biology; Tyrosine; SH3 domain; Receptor tyrosine kinase; Kinase; Chemistry; Biochemistry; Cancer research; Molecular biology; Phosphorylation; Cell biology; Signal transduction","authors":[{"name":"Jeffrey D. Bjorge","is_ca":true},{"name":"Andrew Pang","is_ca":true},{"name":"Donald J. Fujita","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01093740128197034,"gpt":0.2592848422579414,"spread":0.2483474409759711,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087266,0.0003256022,0.0002680951,0.0007489246,0.0002078712,0.0002851923,0.000141146,0.0002606284,0.0008816142],"category_scores_gemma":[0.0001644197,0.0001872833,0.0002494988,0.000485791,0.00009785527,0.00009592251,0.000114363,0.000355733,0.0004516879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658108,"about_ca_system_score_gemma":0.0002169799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001618439,"about_ca_topic_score_gemma":0.001936472,"domain_scores_codex":[0.9998968,0.000007912341,0.000006998917,0.00002446732,0.00004338929,0.00002045369],"domain_scores_gemma":[0.9999399,0.000008861995,0.00001190074,0.000005253013,0.00001556131,0.00001836912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004195839,0.00001291759,0.001013998,0.00003993436,0.000005356479,0.00009465854,0.00001811528,0.00002017512,0.9973823,0.00002172832,0.00004073244,0.001308102],"study_design_scores_gemma":[0.00002378953,0.0001704664,0.1203489,0.00001457171,0.00005456692,0.003065477,0.00005926783,0.001106236,0.8699737,0.00007585569,0.005097047,0.00001024104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877625,0.005961402,0.003161665,0.0001220607,0.00001991947,0.00005355222,0.001703057,0.00006618305,0.001149714],"genre_scores_gemma":[0.9784799,0.005122344,0.007308959,0.00009525591,0.000025406,0.0000846219,0.005656635,0.0000212743,0.003205634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618439,"threshold_uncertainty_score":0.003218055,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2034341688","doi":"10.1016/j.molcel.2006.06.001","title":"The Human and Mouse Complement of SH2 Domain Proteins—Establishing the Boundaries of Phosphotyrosine Signaling","year":2006,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":306,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"SH2 domain; Biology; Signal transduction; Phosphotyrosine-binding domain; Cell biology; Effector; GRB2; Computational biology; Signaling proteins; Protein–protein interaction; SH3 domain; HAMP domain; Signal transducing adaptor protein; Phosphorylation; Protein domain; Tyrosine kinase; Biochemistry; Gene","authors":[{"name":"Bernard A. Liu","is_ca":false},{"name":"Karl Jablonowski","is_ca":false},{"name":"Monica Raina","is_ca":true},{"name":"Michael Arcé","is_ca":false},{"name":"Tony Pawson","is_ca":true},{"name":"Piers Nash","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005126785862642484,"gpt":0.2128722697830925,"spread":0.2077454839204501,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003074114,0.000250259,0.0001534454,0.0003770014,0.0002186009,0.0005472836,0.0003437768,0.0005117357,0.001845019],"category_scores_gemma":[0.0004520605,0.0001687644,0.0001569391,0.0001482025,0.000512626,0.0004001498,0.0004117651,0.0005360321,0.0003346319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006425657,"about_ca_system_score_gemma":0.0003988397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00257139,"about_ca_topic_score_gemma":0.00301596,"domain_scores_codex":[0.9997945,0.00003477527,0.000009505589,0.00002840986,0.00006042388,0.00007237981],"domain_scores_gemma":[0.9997819,0.00004725743,0.0000310872,0.00003688621,0.00003885945,0.00006399469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000655819,0.000009299686,0.000917724,0.00002383534,0.000009682066,0.0002178699,0.00004297417,0.0001622025,0.983158,0.009807034,0.0002249735,0.00477045],"study_design_scores_gemma":[0.00008289856,0.0002412961,0.02187168,0.00002378583,0.00003379679,0.003589909,0.0001554538,0.002424565,0.9494205,0.004256677,0.01787755,0.00002180516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792191,0.003700134,0.005609248,0.0002610586,0.00005158675,0.00001952712,0.0002961266,0.00005255767,0.01079063],"genre_scores_gemma":[0.9963527,0.0003175907,0.001275475,0.00006757905,0.000006770533,0.000007477833,0.0001548435,0.000008903296,0.00180867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00257139,"threshold_uncertainty_score":0.00617224,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1987252087","doi":"10.1038/ncb1515","title":"Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1","year":2006,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":289,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institutes of Health","keywords":"Motility; Cell biology; Phosphatase; Polarity (international relations); Cell; Chemistry; Cell polarity; Biology; Biochemistry; Phosphorylation","authors":[{"name":"Miki Nishio","is_ca":false},{"name":"Kenichi Watanabe","is_ca":false},{"name":"Junko Sasaki","is_ca":false},{"name":"Choji Taya","is_ca":false},{"name":"Shunsuke Takasuga","is_ca":false},{"name":"Ryota Iizuka","is_ca":false},{"name":"Tamás Balla","is_ca":false},{"name":"Masakazu Yamazaki","is_ca":false},{"name":"Hiroshi Watanabe","is_ca":false},{"name":"Reietsu Itoh","is_ca":false},{"name":"Shoko Kuroda","is_ca":false},{"name":"Yasuo Horie","is_ca":false},{"name":"Irmgard Förster","is_ca":false},{"name":"Tak W. Mak","is_ca":true},{"name":"Hiromichi Yonekawa","is_ca":false},{"name":"Josef Penninger","is_ca":false},{"name":"Yasunori Kanaho","is_ca":false},{"name":"Akira Suzuki","is_ca":false},{"name":"Takehiko Sasaki","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.002182079199432841,"gpt":0.2079531636583979,"spread":0.2057710844589651,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001862334,0.0002552299,0.0001708615,0.0002643918,0.0003593663,0.0008387583,0.0002382362,0.0002183567,0.001137853],"category_scores_gemma":[0.0002855528,0.0002626028,0.0002008143,0.0001566534,0.0004598781,0.00044517,0.0007283773,0.000688888,0.0005645641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007070529,"about_ca_system_score_gemma":0.000393569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008769388,"about_ca_topic_score_gemma":0.001517929,"domain_scores_codex":[0.9998697,0.00001809571,0.000006565586,0.00001962306,0.00003769438,0.00004838503],"domain_scores_gemma":[0.9998876,0.00001522919,0.00003494087,0.00001094256,0.00001738263,0.00003394271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004150858,0.00001667327,0.001179023,0.00005284433,0.00001108411,0.0002247736,0.00005133036,0.0008303576,0.9843741,0.002747089,0.0005146157,0.009583156],"study_design_scores_gemma":[0.00008380616,0.0001256245,0.02984369,0.00001356406,0.00002541132,0.000657297,0.0001874451,0.01169303,0.9431896,0.002064958,0.01209131,0.00002425135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810463,0.003291368,0.005790315,0.0005800899,0.00006449701,0.00001606954,0.0002090056,0.0001491371,0.008853344],"genre_scores_gemma":[0.9935295,0.001308562,0.0009135898,0.00005863237,0.00001572873,0.00001362837,0.0001733652,0.00003318798,0.003953785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137853,"threshold_uncertainty_score":0.005130112,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2169763871","doi":"10.1128/mcb.20.22.8513-8525.2000","title":"The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":287,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; Protein tyrosine phosphatase; Receptor tyrosine kinase; Cell biology; Tropomyosin receptor kinase C; Tyrosine kinase; ROR1; Morphogenesis; Phosphatase; Proto-oncogene tyrosine-protein kinase Src; Kinase; Tyrosine; Platelet-derived growth factor receptor; Signal transduction; Receptor; Biochemistry; Phosphorylation; Gene","authors":[{"name":"Christiane R. Maroun","is_ca":false},{"name":"Monica A. Naujokas","is_ca":false},{"name":"Marina Holgado-Madruga","is_ca":false},{"name":"Albert J. Wong","is_ca":false},{"name":"Morag Park","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00690776689317422,"gpt":0.2206788915965416,"spread":0.2137711247033674,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001732305,0.0006544552,0.0002904902,0.0002861564,0.0003283585,0.0005502827,0.0003858285,0.000379651,0.001617859],"category_scores_gemma":[0.0002048754,0.0003543683,0.0003204779,0.0001901722,0.0003160139,0.0003451275,0.0004752809,0.0006598394,0.000787637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000637904,"about_ca_system_score_gemma":0.0004823655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006183,"about_ca_topic_score_gemma":0.001905613,"domain_scores_codex":[0.9997112,0.00003470211,0.00003129584,0.00004800198,0.0001104051,0.00006439869],"domain_scores_gemma":[0.9997602,0.00002283532,0.00008451999,0.00002117587,0.00001959193,0.00009176098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112152,0.00002316982,0.0002869906,0.00003256571,0.00000711273,0.0001583056,0.000008524627,0.00009536315,0.9982925,0.0002015783,0.00006005463,0.0007216473],"study_design_scores_gemma":[0.00005878427,0.00016061,0.0234806,0.0000157493,0.00002999376,0.001219288,0.00006346168,0.004077654,0.963263,0.0001834266,0.007434179,0.0000132662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908419,0.002783844,0.003591487,0.0002528128,0.00005446842,0.00003514023,0.000588098,0.00013508,0.00171723],"genre_scores_gemma":[0.9935219,0.0008131263,0.001418494,0.00006196647,0.00001539236,0.00004010559,0.0010115,0.00002578837,0.003091855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617859,"threshold_uncertainty_score":0.005412221,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2107546866","doi":"10.1128/mcb.22.12.4062-4072.2002","title":"Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":279,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Japan Society for the Promotion of Science; National Cancer Institute; School of Medicine, Stanford University; National Institutes of Health; McGill University","keywords":"Biology; Protein tyrosine phosphatase; Cell biology; Receptor tyrosine kinase; Phosphorylation; PI3K/AKT/mTOR pathway; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Tyrosine phosphorylation; Phosphatidylinositol; Phosphatase; Kinase; MAPK/ERK pathway; Tyrosine kinase; GRB2; Tyrosine; Molecular biology; Biochemistry","authors":[{"name":"Si Qing Zhang","is_ca":false},{"name":"William G. Tsiaras","is_ca":false},{"name":"Toshiyuki Araki","is_ca":false},{"name":"Gengyun Wen","is_ca":false},{"name":"Liliana Minichiello","is_ca":false},{"name":"Rüdiger Klein","is_ca":false},{"name":"Benjamin G. Neel","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008203254181976241,"gpt":0.2053044579311211,"spread":0.1971012037491448,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158653,0.0003547734,0.000134124,0.0001646104,0.0001465024,0.0004414132,0.0001751677,0.0001652455,0.001356587],"category_scores_gemma":[0.0001298917,0.0001574309,0.0002220701,0.0001407424,0.0001520401,0.0002490836,0.0003257059,0.0004345133,0.0004661312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003729926,"about_ca_system_score_gemma":0.0001582025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006531772,"about_ca_topic_score_gemma":0.000956576,"domain_scores_codex":[0.9998765,0.00001460367,0.000008864679,0.00002581246,0.0000371919,0.00003709176],"domain_scores_gemma":[0.9999449,0.000009153184,0.00001482466,0.00000682944,0.00001049787,0.00001385952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007628038,0.00001054872,0.0001678744,0.00002223358,0.00000354244,0.0000518199,0.000008818019,0.00005088716,0.9984492,0.0001757385,0.00007155001,0.0009113821],"study_design_scores_gemma":[0.00002799341,0.00008476989,0.01121291,0.000005798094,0.00001280932,0.0002824513,0.00005145012,0.002319398,0.9809279,0.0001244527,0.004943272,0.000006757276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898549,0.002886862,0.002763934,0.0001730245,0.00004573645,0.00002243014,0.0004363283,0.0001080309,0.003708594],"genre_scores_gemma":[0.9936539,0.001521411,0.0008235562,0.00006138765,0.00001307189,0.00003346803,0.0004819095,0.00002123778,0.003390064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356587,"threshold_uncertainty_score":0.004538298,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2109470426","doi":"10.2337/db08-0913","title":"Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress","year":2008,"lang":"en","type":"article","venue":"Diabetes","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":279,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Internal medicine; Endocrinology; Glucose homeostasis; Biology; Insulin; Insulin receptor; Endoplasmic reticulum; Unfolded protein response; Carbohydrate metabolism; Insulin resistance; Lipid metabolism; Homeostasis; Protein tyrosine phosphatase; Glucokinase; Glucose tolerance test; Medicine; Biochemistry; Receptor","authors":[{"name":"Mirela Delibegović","is_ca":false},{"name":"Derek J. Zimmer","is_ca":false},{"name":"Caitlin Kauffman","is_ca":false},{"name":"Kimberly J. Rak","is_ca":false},{"name":"Eun‐Gyoung Hong","is_ca":false},{"name":"You-Ree Cho","is_ca":false},{"name":"Jason K. Kim","is_ca":false},{"name":"Barbara B. Kahn","is_ca":false},{"name":"Benjamin G. Neel","is_ca":true},{"name":"Kendra K. Bence","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00941631473801458,"gpt":0.2025189133012053,"spread":0.1931025985631908,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775532,0.0007899371,0.0005907887,0.0004911298,0.0001608648,0.0002608312,0.0002654155,0.0003755397,0.002101944],"category_scores_gemma":[0.0001508567,0.0002238078,0.0002553969,0.0002152661,0.0003177099,0.0002764158,0.000211827,0.0008107434,0.0004506456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867272,"about_ca_system_score_gemma":0.00017364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003635769,"about_ca_topic_score_gemma":0.0005076157,"domain_scores_codex":[0.9998684,0.00001942526,0.00001499034,0.00003182916,0.00003353735,0.00003183876],"domain_scores_gemma":[0.9997674,0.00001355975,0.0001037805,0.00001555376,0.00001806405,0.00008159263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007809468,0.0001648809,0.0004627034,0.0000855098,0.0000232797,0.00005259146,0.000008662762,0.00009125879,0.9949033,0.0000445487,0.00008341044,0.003298832],"study_design_scores_gemma":[0.0006171709,0.003687778,0.0269869,0.00005085453,0.0002186639,0.001008109,0.00007231058,0.001687149,0.9624101,0.0001177468,0.003126641,0.00001669103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933378,0.002748469,0.002312538,0.0001643115,0.00005435555,0.00003304732,0.0004891431,0.0002474933,0.0006129474],"genre_scores_gemma":[0.9904174,0.002640975,0.00293966,0.000101409,0.00003391186,0.00007216311,0.00108859,0.00007067562,0.002635285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002101944,"threshold_uncertainty_score":0.007031739,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2118719488","doi":"10.1172/jci44972","title":"Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Ontario Ministry of Health and Long-Term Care; Howard Hughes Medical Institute","keywords":"PTPN11; Noonan syndrome; Protein tyrosine phosphatase; Hypertrophic cardiomyopathy; Biology; Endocrinology; PI3K/AKT/mTOR pathway; Cancer research; MAPK/ERK pathway; Mutation; PTEN; Internal medicine; Cardiomyopathy; Cell biology; Medicine; Signal transduction; Genetics; Heart failure; Gene","authors":[{"name":"Talita Miguel Marin","is_ca":false},{"name":"Kimberly Keith","is_ca":false},{"name":"Benjamin Davies","is_ca":false},{"name":"David A. Conner","is_ca":false},{"name":"Prajna Guha","is_ca":false},{"name":"Demetrios Kalaitzidis","is_ca":false},{"name":"Xue Wu","is_ca":true},{"name":"Jessica Lauriol","is_ca":false},{"name":"Bo Wang","is_ca":false},{"name":"Michael Bauer","is_ca":false},{"name":"Roderick T. Bronson","is_ca":false},{"name":"Kleber G. Franchini","is_ca":false},{"name":"Benjamin G. Neel","is_ca":true},{"name":"Maria Kontaridis","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08745430573202027,"gpt":0.3159085214508894,"spread":0.2284542157188691,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003534021,0.0009592167,0.000586077,0.0006719515,0.000302223,0.0002824719,0.000477691,0.00109682,0.001515578],"category_scores_gemma":[0.0001744719,0.0003746304,0.0004553444,0.0002065924,0.000492428,0.000342115,0.0001993346,0.001577883,0.0005490015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004127151,"about_ca_system_score_gemma":0.0004162655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007262218,"about_ca_topic_score_gemma":0.001390828,"domain_scores_codex":[0.9996779,0.00007027356,0.00004903471,0.00007240375,0.00006036316,0.00007004345],"domain_scores_gemma":[0.9996955,0.00003897756,0.00009598182,0.00002862504,0.00002411024,0.0001168305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007296932,0.0004201948,0.0002807169,0.00008493257,0.00002591584,0.0002928306,0.00002496982,0.0001912144,0.9957544,0.0002305299,0.0002666113,0.001698163],"study_design_scores_gemma":[0.0009006851,0.008303271,0.01205757,0.00006847778,0.0001582583,0.002461128,0.0001341707,0.00637856,0.9619874,0.0003072757,0.007202441,0.00004071174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890563,0.001715013,0.003437577,0.0007019839,0.0003112686,0.0001999317,0.001485394,0.0007225129,0.002370005],"genre_scores_gemma":[0.9846212,0.001668512,0.005110844,0.0004268519,0.00009041182,0.0004412715,0.001968124,0.0001015584,0.005571418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515578,"threshold_uncertainty_score":0.00507009,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2143963530","doi":"10.1136/jmg.2006.042796","title":"The cardiofaciocutaneous syndrome","year":2006,"lang":"en","type":"review","venue":"Journal of Medical Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":270,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Costello syndrome; PTPN11; Noonan syndrome; HRAS; Failure to thrive; Biology; Hypertelorism; KRAS; Cancer research; MAPK/ERK pathway; Mutation; Genetics; Medicine; Internal medicine; Kinase; Gene","authors":[{"name":"Amy E. Roberts","is_ca":false},{"name":"Judith Allanson","is_ca":true},{"name":"Suzanne K. Jadico","is_ca":false},{"name":"Maria Inês Kavamura","is_ca":false},{"name":"Jacqueline A. Noonan","is_ca":false},{"name":"John M. Opitz","is_ca":false},{"name":"Terry‐Lynn Young","is_ca":false},{"name":"Giovanni Neri","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01812208958461606,"gpt":0.3241717965936134,"spread":0.3060497070089973,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070828,0.001369571,0.0003699386,0.001116334,0.0008135872,0.0004888307,0.0003504092,0.0007820014,0.0185994],"category_scores_gemma":[0.001247531,0.0001224351,0.0003335849,0.001062682,0.0005831965,0.0002739989,0.0007898039,0.0006126165,0.001637322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713282,"about_ca_system_score_gemma":0.0007351342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004052032,"about_ca_topic_score_gemma":0.004211339,"domain_scores_codex":[0.9996772,0.00002900167,0.00001422337,0.0000938116,0.00009423376,0.0000916119],"domain_scores_gemma":[0.9997244,0.00005685511,0.00006427823,0.00001848413,0.00005522982,0.00008079962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004303551,0.0001687491,0.09110329,0.001252315,0.0003234596,0.3962655,0.001018622,0.0009140889,0.05767471,0.02292061,0.0893512,0.3385771],"study_design_scores_gemma":[0.00008547928,0.00009838351,0.06124664,0.0003802561,0.0001481806,0.8065526,0.0002989988,0.0004444743,0.003561832,0.002300711,0.1248217,0.00006083081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5973143,0.04057938,0.01013095,0.005491974,0.00147858,0.0003418024,0.005990593,0.001809278,0.3368632],"genre_scores_gemma":[0.9614326,0.006783463,0.002971913,0.00181905,0.000294076,0.0001060185,0.001675827,0.0001139354,0.02480306],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0185994,"threshold_uncertainty_score":0.06222117,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2024744542","doi":"10.1016/j.tins.2013.06.002","title":"Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization","year":2013,"lang":"en","type":"review","venue":"Trends in Neurosciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Montreal Clinical Research Institute; University of British Columbia","funders":"National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Neurexin; Postsynaptic potential; Neuroscience; Synapse; Protein tyrosine phosphatase; Agrin; Biology; Neuroligin; Neurotransmission; Postsynaptic density; Cell biology; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Receptor; Signal transduction; Biochemistry","authors":[{"name":"Hideto Takahashi","is_ca":true},{"name":"Ann Marie Craig","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04029732418721039,"gpt":0.3270293841975881,"spread":0.2867320600103778,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005220039,0.000972961,0.00106752,0.001080554,0.0002314202,0.001016975,0.001176895,0.001124351,0.002270456],"category_scores_gemma":[0.0004239531,0.0002676923,0.0002656773,0.001539248,0.0006391741,0.001432494,0.00077661,0.001885835,0.00211865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008024536,"about_ca_system_score_gemma":0.001124135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007834989,"about_ca_topic_score_gemma":0.001933026,"domain_scores_codex":[0.9998631,0.00001278697,0.00001547289,0.00002604162,0.00006173038,0.00002078985],"domain_scores_gemma":[0.9998314,0.00003437746,0.00003782105,0.000006451146,0.00005890274,0.0000310581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001109619,0.00003327655,0.0002153771,0.005416139,0.0000740322,0.0002434781,0.00002641681,0.000352018,0.005185969,0.0061061,0.04885652,0.9333797],"study_design_scores_gemma":[0.000027057,0.00003855761,0.0008129964,0.0006646648,0.00009749547,0.001238433,0.00004013106,0.0001630829,0.001362595,0.003136376,0.9923995,0.00001916311],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000289806,0.9967948,0.0005931277,0.0007208828,0.0003355956,0.000004571793,0.00003387822,0.00002526245,0.001202195],"genre_scores_gemma":[0.001594037,0.9961244,0.0004582224,0.0002702955,0.0002837017,0.000006546565,0.00005130533,0.000002425021,0.00120898],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002270456,"threshold_uncertainty_score":0.00759542,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2004731962","doi":"10.1073/pnas.1218173110","title":"NMR-based functional profiling of RASopathies and oncogenic RAS mutations","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Canada Research Chairs; Ontario Ministry of Health and Long-Term Care; Princess Margaret Hospital Foundation; Cancer Research Society","keywords":"Noonan syndrome; Allosteric regulation; Mutant; GTPase; Neurofibromin 1; Biology; GTPase-activating protein; Costello syndrome; Signal transduction; Mutation; Cell biology; Genetics; Gene; G protein; Receptor","authors":[{"name":"Matthew J. Smith","is_ca":true},{"name":"Benjamin G. Neel","is_ca":true},{"name":"Mitsuhiko Ikura","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02709367950051057,"gpt":0.2755156047787579,"spread":0.2484219252782473,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856269,0.0003737076,0.0001626323,0.0004188951,0.0001469013,0.0001635952,0.0001925706,0.0003242519,0.0007161839],"category_scores_gemma":[0.0001826106,0.0001092699,0.0001506964,0.0001609526,0.0001765067,0.0001662886,0.0001576527,0.0002867485,0.0001660486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914735,"about_ca_system_score_gemma":0.00008295463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005377269,"about_ca_topic_score_gemma":0.0006887299,"domain_scores_codex":[0.9999138,0.0000175719,0.000006125044,0.00002150885,0.00002140033,0.00001951492],"domain_scores_gemma":[0.9998474,0.00003635067,0.00003574461,0.00001209277,0.00003491146,0.00003344052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002637674,0.000004489914,0.0001541061,0.000009077535,0.00000243489,0.00001604365,0.00000954458,0.0000739426,0.9992926,0.00002599938,0.000007949077,0.0003774721],"study_design_scores_gemma":[0.000003755209,0.0001438186,0.006936775,0.00000312314,0.00002209275,0.0002808172,0.00004412828,0.003268071,0.9886329,0.00005469775,0.000602328,0.000007587265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891812,0.0004039572,0.008436408,0.0000612929,0.000007154589,0.00001806111,0.0007499161,0.00009983083,0.001042165],"genre_scores_gemma":[0.9895965,0.0004655377,0.008168547,0.0000327971,0.000006581024,0.00003450305,0.0006967586,0.00003274131,0.0009660023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007161839,"threshold_uncertainty_score":0.002395868,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2144146259","doi":"10.1016/j.beem.2007.08.004","title":"Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus","year":2007,"lang":"en","type":"review","venue":"Best Practice & Research Clinical Endocrinology & Metabolism","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Mount Sinai Hospital; University Health Network; University of Toronto","funders":"","keywords":"Insulin resistance; Insulin receptor; Protein tyrosine phosphatase; Insulin; Endocrinology; Internal medicine; Type 2 diabetes; Type 2 Diabetes Mellitus; Phosphorylation; IRS1; Dephosphorylation; Diabetes mellitus; Biology; Medicine; Phosphatase; Receptor; Biochemistry","authors":[{"name":"Shlomit Koren","is_ca":false},{"name":"I. George Fantus","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1031528505575023,"gpt":0.4516923393027854,"spread":0.3485394887452831,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006164425,0.001097705,0.001771235,0.001211383,0.0002542216,0.0007530302,0.001146766,0.001304135,0.002849231],"category_scores_gemma":[0.0004832507,0.0002795641,0.0004735032,0.001192774,0.0005241937,0.0009131169,0.0005339404,0.00287592,0.00245808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005150955,"about_ca_system_score_gemma":0.0005937424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008044492,"about_ca_topic_score_gemma":0.002108288,"domain_scores_codex":[0.9998416,0.00002073656,0.00001553921,0.00002840128,0.00007456014,0.00001921712],"domain_scores_gemma":[0.9998216,0.00007247785,0.0000263478,0.000005623494,0.00004567726,0.00002835887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002370369,0.0001907035,0.000150132,0.004721113,0.0001019014,0.0003572755,0.0000310237,0.0005112128,0.004704508,0.002785706,0.05052899,0.9356804],"study_design_scores_gemma":[0.0002033556,0.0002610397,0.0009198721,0.0009170442,0.0001555416,0.001898043,0.0000313594,0.0002544474,0.001657025,0.00185476,0.9918211,0.00002657425],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00033589,0.9967307,0.0005334292,0.0005227746,0.0005108613,0.000009692485,0.00002501233,0.00002060899,0.001311071],"genre_scores_gemma":[0.001577978,0.9954579,0.0005752985,0.0004617659,0.0003078796,0.00001766597,0.00005637627,0.000003276564,0.0015419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002849231,"threshold_uncertainty_score":0.009531617,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1991863758","doi":"10.1042/bj20081986","title":"Evolution of protein phosphatases in plants and animals","year":2008,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":253,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Phosphatase; Protein tyrosine phosphatase; Phosphorylation; Biology; Biochemistry; DUSP6; Serine; Threonine; Protein phosphorylation; Kinase; Phosphoprotein; Convergent evolution; Protein phosphatase 2; Computational biology; Gene; Protein kinase A; Phylogenetics","authors":[{"name":"Greg B. G. Moorhead","is_ca":true},{"name":"Veerle De Wever","is_ca":true},{"name":"George W. Templeton","is_ca":true},{"name":"David Kerk","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02029173475823882,"gpt":0.2905910213561527,"spread":0.2702992865979139,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000369534,0.0006256672,0.0007614431,0.001160323,0.0003209671,0.0006879449,0.000626716,0.0008901627,0.00139833],"category_scores_gemma":[0.0004386682,0.0002438475,0.0002576333,0.002007046,0.000662383,0.001172235,0.0005128518,0.001028017,0.001352923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007477351,"about_ca_system_score_gemma":0.0008475847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178006,"about_ca_topic_score_gemma":0.001188453,"domain_scores_codex":[0.9998529,0.0000169898,0.00001598088,0.00003815563,0.00006391659,0.0000120709],"domain_scores_gemma":[0.999892,0.00003312971,0.00001785456,0.000005638987,0.00003459438,0.00001681493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000677511,0.00002844524,0.000406671,0.006206607,0.00004574455,0.0004105375,0.0001035305,0.0006321547,0.007001644,0.008093015,0.01350713,0.9634968],"study_design_scores_gemma":[0.00001025977,0.00005317573,0.001622463,0.0007786663,0.0000447656,0.001740942,0.00006160738,0.0001048067,0.001143578,0.004904706,0.989523,0.0000121023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004744989,0.9964709,0.0003970983,0.0002838814,0.0001736741,0.00000391254,0.00001199622,0.000009932775,0.002174178],"genre_scores_gemma":[0.002027079,0.9962623,0.000365022,0.0001506533,0.0001324821,0.000004328056,0.00002154993,0.000001302224,0.001035364],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00139833,"threshold_uncertainty_score":0.005425274,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1973173778","doi":"10.1038/ng.904","title":"The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness","year":2011,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Royal Victoria Regional Health Centre; Canadian Institutes of Health Research; Princess Margaret Cancer Centre; Royal Victoria Hospital; University of Toronto; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"PTPN22; Calpain; Biology; Molecular biology; Immunology; Autoimmune disease; Autoimmunity; Antibody; Gene; Biochemistry; Genotype; Enzyme","authors":[{"name":"Jinyi Zhang","is_ca":true},{"name":"Naima Zahir","is_ca":true},{"name":"Qiuhong Jiang","is_ca":true},{"name":"Helen Miliotis","is_ca":true},{"name":"Stéphanie Heyraud","is_ca":true},{"name":"Xianwang Meng","is_ca":true},{"name":"Baoxia Dong","is_ca":true},{"name":"Gang Xie","is_ca":true},{"name":"Frank Qiu","is_ca":true},{"name":"Zhenyue Hao","is_ca":true},{"name":"Christopher A. McCulloch","is_ca":true},{"name":"Edward Keystone","is_ca":true},{"name":"Alan C. Peterson","is_ca":true},{"name":"Katherine A. Siminovitch","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007090732544122032,"gpt":0.2063910014012272,"spread":0.1993002688571052,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001980461,0.0004820199,0.0002668587,0.000301436,0.0001808818,0.0003348863,0.0002150115,0.0005072005,0.002482499],"category_scores_gemma":[0.0003953923,0.0001589995,0.0003145132,0.0001407598,0.0003161809,0.0001809327,0.0003280024,0.0007931186,0.0004278296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153523,"about_ca_system_score_gemma":0.0001025876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003531893,"about_ca_topic_score_gemma":0.0003973566,"domain_scores_codex":[0.999792,0.00004683991,0.00002672734,0.00004578398,0.00003821657,0.00005044102],"domain_scores_gemma":[0.9997181,0.00006043592,0.00008021331,0.00003399462,0.00001951892,0.00008765267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00054586,0.00005743843,0.002673039,0.00002075051,0.00002005849,0.003592595,0.00002178706,0.00006466494,0.9916943,0.0001527072,0.0001378137,0.001019007],"study_design_scores_gemma":[0.0003641341,0.001578827,0.1827974,0.00002283828,0.0001692685,0.08208274,0.0002137382,0.00493722,0.7224079,0.0007786963,0.004607382,0.00003978337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985173,0.0002978293,0.0004988583,0.00008310698,0.00002663224,0.000007414078,0.00009945873,0.00002324844,0.0004461871],"genre_scores_gemma":[0.9991085,0.00008355126,0.0001868144,0.00003458131,0.00001612825,0.00000481391,0.0001028628,0.00001126172,0.0004514645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002482499,"threshold_uncertainty_score":0.008304775,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2049020090","doi":"10.1136/jmedgenet-2015-103018","title":"Rare variants in <i>SOS2</i> and <i>LZTR1</i> are associated with Noonan syndrome","year":2015,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":245,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Noonan syndrome; Proband; Genetics; PTPN11; Missense mutation; Pedigree chart; Biology; Exome sequencing; Exome; Gene; Mutation; KRAS","authors":[{"name":"Guilherme Lopes Yamamoto","is_ca":false},{"name":"Meire Aguena","is_ca":false},{"name":"Monika Goś","is_ca":false},{"name":"Christina Hung","is_ca":false},{"name":"Jacek Pilch","is_ca":false},{"name":"Somayyeh Fahiminiya","is_ca":true},{"name":"Anna Abramowicz","is_ca":false},{"name":"Ingrid Cristian","is_ca":false},{"name":"Michelle Buscarilli","is_ca":false},{"name":"Michel Satya Naslavsky","is_ca":false},{"name":"Alexsandra C. Malaquias","is_ca":false},{"name":"Mayana Zatz","is_ca":false},{"name":"Olaf A. Bodamer","is_ca":false},{"name":"Jacek Majewski","is_ca":true},{"name":"Alexander A.L. Jorge","is_ca":false},{"name":"Alexandre C. Pereira","is_ca":false},{"name":"Chong Ae Kim","is_ca":false},{"name":"Maria Rita Passos‐Bueno","is_ca":false},{"name":"Débora Romeo Bertola","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01481811098303938,"gpt":0.2477166745522687,"spread":0.2328985635692293,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210151,0.0008853198,0.0003683248,0.001059592,0.0004500349,0.000400137,0.0003944073,0.0005750983,0.002315082],"category_scores_gemma":[0.001442577,0.0002560023,0.000367741,0.0007675612,0.0006347295,0.0001428598,0.0004643952,0.000311597,0.0002960243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490717,"about_ca_system_score_gemma":0.0002696881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003202039,"about_ca_topic_score_gemma":0.004360338,"domain_scores_codex":[0.9997566,0.00002942787,0.00003371606,0.00007550784,0.00006266843,0.00004204259],"domain_scores_gemma":[0.9993499,0.0001222792,0.0003644791,0.00003671679,0.00004586339,0.00008083176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000663503,0.00007732138,0.7711572,0.0002051216,0.000273971,0.08478752,0.001344561,0.0003056549,0.1298081,0.0005006564,0.0004691607,0.01040715],"study_design_scores_gemma":[0.00006876828,0.0001566315,0.773244,0.00008976443,0.000262058,0.2123263,0.0005197392,0.0005289018,0.01002132,0.0004067419,0.002347779,0.00002801679],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99854,0.0002183944,0.0002419225,0.0000428399,0.000004147078,0.000009196485,0.0001275416,0.00001483532,0.0008011218],"genre_scores_gemma":[0.9992909,0.0001609672,0.0002701152,0.0000265034,0.000006746412,0.000005026635,0.0001235213,0.000006597426,0.0001095668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003202039,"threshold_uncertainty_score":0.00774467,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2006224306","doi":"10.1073/pnas.0610906104","title":"Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy <i>in vivo</i>","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":244,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Pressure overload; Endocrinology; Biology; Internal medicine; Muscle hypertrophy; Stimulation; Signal transduction; Phosphatase; MAPK/ERK pathway; Heart failure; Phosphorylation; DUSP6; Cell biology; Medicine; Protein phosphatase 2","authors":[{"name":"Nicole H. Purcell","is_ca":false},{"name":"Benjamin J. Wilkins","is_ca":false},{"name":"Allen J. York","is_ca":false},{"name":"Marc K. Saba-El-Leil","is_ca":true},{"name":"Sylvain Meloche","is_ca":true},{"name":"Jeffrey Robbins","is_ca":false},{"name":"Jeffery D. Molkentin","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01391599406268416,"gpt":0.2554307523499697,"spread":0.2415147582872856,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002237508,0.0006786748,0.000362829,0.0004095593,0.0001947535,0.0003563058,0.0003514406,0.0004379487,0.0024063],"category_scores_gemma":[0.0001395838,0.0003007273,0.0004043167,0.0001426269,0.0005110372,0.0003057212,0.0001991311,0.001078945,0.0006373324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946642,"about_ca_system_score_gemma":0.0002516118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006036967,"about_ca_topic_score_gemma":0.001108234,"domain_scores_codex":[0.999781,0.00002858722,0.00002767515,0.00005072468,0.00005651924,0.00005558264],"domain_scores_gemma":[0.999715,0.00003954938,0.0000813735,0.00003169157,0.0000176599,0.0001147313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002278819,0.00009135339,0.0001265192,0.00002209515,0.000006009123,0.00004561008,0.000008005341,0.00005086561,0.9988492,0.00007796021,0.00004308227,0.0004513749],"study_design_scores_gemma":[0.0000728922,0.0008015967,0.004976199,0.00001001011,0.0000221987,0.000334379,0.00003652204,0.001238139,0.9911582,0.00006865243,0.001273491,0.000007699688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934896,0.0008562315,0.002557226,0.0002458293,0.00009091262,0.00004287857,0.0006677167,0.0002087877,0.001840772],"genre_scores_gemma":[0.9888555,0.0008933039,0.002706196,0.0001632449,0.00003202341,0.000105447,0.001126075,0.00008711201,0.006030987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0024063,"threshold_uncertainty_score":0.008049846,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2137303374","doi":"10.1002/ajmg.a.20665","title":"3D analysis of facial morphology","year":2004,"lang":"en","type":"article","venue":"American Journal of Medical Genetics Part A","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Wellcome Trust","keywords":"Logistic regression; Artificial intelligence; Contrast (vision); Identification (biology); Support vector machine; Facial recognition system; Computer science; Face (sociological concept); Pattern recognition (psychology); Psychology; Machine learning; Biology","authors":[{"name":"Peter Hammond","is_ca":false},{"name":"Tim J. Hutton","is_ca":false},{"name":"Judith Allanson","is_ca":true},{"name":"Linda Campbell","is_ca":false},{"name":"Raoul C. M. Hennekam","is_ca":false},{"name":"Sean B. Holden","is_ca":false},{"name":"Michael A. Patton","is_ca":false},{"name":"Adam Shaw","is_ca":false},{"name":"I. Karen Temple","is_ca":false},{"name":"Matthew Trotter","is_ca":false},{"name":"Kieran C. Murphy","is_ca":false},{"name":"Robin M. Winter","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008782374160354947,"gpt":0.2857535774366663,"spread":0.2769712032763114,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003668918,0.0004719232,0.0004114712,0.002479982,0.0001870954,0.0009991936,0.0003048332,0.000413936,0.004362032],"category_scores_gemma":[0.001253758,0.0003339231,0.0007702099,0.00105592,0.0002775691,0.0004791093,0.0007669952,0.0003049562,0.001436033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735957,"about_ca_system_score_gemma":0.0003155208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002515886,"about_ca_topic_score_gemma":0.002874267,"domain_scores_codex":[0.9996562,0.00005350028,0.00001799275,0.00007077773,0.0001707227,0.00003070511],"domain_scores_gemma":[0.9995795,0.0001274825,0.00004320571,0.0001122118,0.0001175605,0.00001990825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002666878,0.00008992154,0.02484582,0.0003115449,0.000207058,0.0006363556,0.0007080869,0.1112527,0.2305537,0.007038427,0.008163775,0.615926],"study_design_scores_gemma":[0.00001920138,0.0001109622,0.06570561,0.00007172224,0.00005693616,0.001545132,0.0003146442,0.8713282,0.03989002,0.00725698,0.01361323,0.00008725971],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1530298,0.0004575489,0.8324405,0.0002479521,0.00007580005,0.0001428074,0.003796567,0.003707049,0.006101987],"genre_scores_gemma":[0.7229369,0.0007761044,0.2683897,0.00009120266,0.00004066228,0.0001930992,0.003936235,0.0004086473,0.003227518],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004362032,"threshold_uncertainty_score":0.01459253,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2254051095","doi":"10.1038/ncomms9859","title":"Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; University Health Network; SickKids Foundation; Hospital for Sick Children; Princess Margaret Cancer Centre; Canada Research Chairs","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Dephosphorylation; Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; MAPK/ERK pathway; Phosphorylation; Cancer research; GTPase; Phosphatase; Biology; Small GTPase; Activator (genetics); Anti-apoptotic Ras signalling cascade; Carcinogenesis; Cell growth; Kinase; Glioma; Signal transduction; Effector; Cell biology; Cancer; Biochemistry; Receptor; Genetics","authors":[{"name":"Severa Bunda","is_ca":true},{"name":"Kelly Burrell","is_ca":true},{"name":"Pardeep Heir","is_ca":true},{"name":"Li‐Fan Zeng","is_ca":false},{"name":"Amir Alamsahebpour","is_ca":true},{"name":"Yoshihito Kano","is_ca":true},{"name":"Brian Raught","is_ca":true},{"name":"Zhong‐Yin Zhang","is_ca":false},{"name":"Gelareh Zadeh","is_ca":true},{"name":"Michael Ohh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02166474953791188,"gpt":0.2933263509766934,"spread":0.2716616014387815,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009632922,0.0003453148,0.0002240269,0.0001730859,0.0001152456,0.0002389592,0.0001836432,0.0001635425,0.001692325],"category_scores_gemma":[0.00006905839,0.0001094297,0.0001645839,0.0001744749,0.0001956355,0.0001350484,0.0001834532,0.000539374,0.0003486068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922911,"about_ca_system_score_gemma":0.0002075993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005432824,"about_ca_topic_score_gemma":0.001315789,"domain_scores_codex":[0.9998837,0.00001476413,0.00001005156,0.00001668575,0.0000421211,0.00003275274],"domain_scores_gemma":[0.9999485,0.000009476438,0.00001049832,0.000007651526,0.000004910089,0.00001897611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001239883,0.0000616041,0.0001103657,0.00002756228,0.000005599158,0.0000369083,0.000009132649,0.0000786595,0.9977654,0.0001279097,0.0001115515,0.001541327],"study_design_scores_gemma":[0.00001571505,0.0002449014,0.001403598,0.000001969963,0.000006580166,0.000102191,0.00001144542,0.0006336917,0.9951626,0.00002772203,0.002388112,0.000001585087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941432,0.0009667444,0.001584652,0.0001183496,0.0000494776,0.00002098639,0.0004019559,0.0001287998,0.002585856],"genre_scores_gemma":[0.9949608,0.0007050632,0.0007154765,0.0000293132,0.00001192439,0.00003075784,0.0005689433,0.00001501109,0.002962763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692325,"threshold_uncertainty_score":0.005661368,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2025316432","doi":"10.1016/j.ceb.2005.02.001","title":"Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP","year":2005,"lang":"en","type":"review","venue":"Current Opinion in Cell Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Health Canada; Cancer Research Institute","keywords":"Biology; Protein tyrosine phosphatase; Cell biology; Signal transduction; Dephosphorylation; Tyrosine kinase 2; Phosphatase; SH2 domain; Cytokine receptor; Phosphorylation; JAK-STAT signaling pathway; Receptor; SOCS3; Janus kinase 1; Receptor tyrosine kinase; Janus kinase; Biochemistry; STAT3; Platelet-derived growth factor receptor; Growth factor","authors":[{"name":"Annie Bourdeau","is_ca":true},{"name":"Nadia Dubé","is_ca":true},{"name":"Michel L. Tremblay","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03788044105027752,"gpt":0.325537138000393,"spread":0.2876566969501154,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267866,0.001135007,0.002300718,0.001189708,0.0003486372,0.001682223,0.00213431,0.002585893,0.00246413],"category_scores_gemma":[0.0009598676,0.0004384092,0.0003812094,0.002723966,0.001236625,0.003136936,0.0009555795,0.003356358,0.001815295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001315269,"about_ca_system_score_gemma":0.001604614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270193,"about_ca_topic_score_gemma":0.002290798,"domain_scores_codex":[0.9996912,0.00003450553,0.00003760967,0.00007481958,0.0001258985,0.00003593801],"domain_scores_gemma":[0.9995034,0.0001751981,0.00005900675,0.000016013,0.0001575788,0.00008879173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002226264,0.0000611617,0.0002436226,0.00955009,0.00008262237,0.0004725379,0.00007131288,0.0005657631,0.007590154,0.008056758,0.07579113,0.8972922],"study_design_scores_gemma":[0.00005097259,0.00006875767,0.0008170289,0.000931922,0.00008380142,0.002159137,0.0001001426,0.0002235956,0.0006771741,0.004661473,0.9902003,0.00002561919],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001239194,0.9977278,0.000326245,0.0007437225,0.0006301772,0.000002192924,0.00001175923,0.000006905341,0.0004273276],"genre_scores_gemma":[0.000808422,0.9963706,0.0003723144,0.0006588433,0.0009585021,0.000006528342,0.00003856281,0.000001793166,0.0007845132],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002585893,"threshold_uncertainty_score":0.009542942,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2016596969","doi":"10.1172/jci44929","title":"MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph; Princess Margaret Cancer Centre; Heart and Stroke Foundation; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Noonan syndrome; Costello syndrome; MAPK/ERK pathway; Mutation; Biology; Germline mutation; Cancer research; Endocrinology; Haploinsufficiency; Internal medicine; Phenotype; Kinase; Medicine; Genetics; Gene","authors":[{"name":"Xue Wu","is_ca":true},{"name":"Jeremy A. Simpson","is_ca":false},{"name":"Jenny H. Hong","is_ca":false},{"name":"Kyoung-Han Kim","is_ca":false},{"name":"Nirusha K. Thavarajah","is_ca":false},{"name":"Peter H. Backx","is_ca":false},{"name":"Benjamin G. Neel","is_ca":true},{"name":"Toshiyuki Araki","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06381907646871447,"gpt":0.2980467769607393,"spread":0.2342277004920248,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003084886,0.0009005809,0.0004714671,0.0006279199,0.0002834901,0.0003589232,0.0004658159,0.000848291,0.001687603],"category_scores_gemma":[0.0001654537,0.0003736971,0.000432733,0.0001812516,0.0004804133,0.0003891013,0.0002341271,0.001383759,0.0004815209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003505273,"about_ca_system_score_gemma":0.0003498041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008191246,"about_ca_topic_score_gemma":0.001676602,"domain_scores_codex":[0.9996915,0.00005439697,0.00004726082,0.00006332773,0.00006714132,0.0000763841],"domain_scores_gemma":[0.9997296,0.00002961593,0.00006582762,0.00002211633,0.00001982013,0.0001330922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007694585,0.0004410722,0.0001944691,0.00006635358,0.00001695341,0.0001693091,0.00004615003,0.0001739453,0.9959221,0.0002732371,0.0001517928,0.001775209],"study_design_scores_gemma":[0.000574481,0.006212251,0.009856338,0.00006548655,0.0001218862,0.001091294,0.0001976263,0.006096655,0.9694295,0.0004995566,0.005812095,0.00004288066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944313,0.0009575493,0.001509718,0.0003358709,0.0001362206,0.00007418944,0.0006285481,0.0002462732,0.001680267],"genre_scores_gemma":[0.9911762,0.001067621,0.001996399,0.0001681808,0.00002921507,0.0001395413,0.0006782845,0.00005239364,0.004692134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001687603,"threshold_uncertainty_score":0.005645633,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1980704335","doi":"10.1128/mcb.20.5.1526-1536.2000","title":"Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Protein tyrosine phosphatase; Stimulation; MAPK/ERK pathway; Cell biology; Phosphatase; Mechanism (biology); Function (biology); Growth factor; Dual-specificity phosphatase; DUSP6; Biochemistry; Phosphorylation; Protein phosphatase 2; Endocrinology; Receptor","authors":[{"name":"Zhongqing Shi","is_ca":false},{"name":"Dehua Yu","is_ca":false},{"name":"Morag Park","is_ca":true},{"name":"Mark S. Marshall","is_ca":false},{"name":"Gen‐Sheng Feng","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008153124601243834,"gpt":0.2303969258665292,"spread":0.2222438012652853,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433047,0.0006201758,0.0001967214,0.0001733792,0.0001604955,0.000283813,0.0002091073,0.0002643543,0.001289392],"category_scores_gemma":[0.00007498488,0.0001555638,0.0003402794,0.00008552557,0.0002238964,0.0002603296,0.0002929424,0.0005248159,0.0004101406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071101,"about_ca_system_score_gemma":0.0001834794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002669025,"about_ca_topic_score_gemma":0.0002600366,"domain_scores_codex":[0.9999311,0.000009731213,0.000004330308,0.00001389935,0.00001917863,0.00002176179],"domain_scores_gemma":[0.9999645,0.000005622442,0.000006448824,0.000004776216,0.000005929032,0.00001267815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248285,0.00003306728,0.0003618374,0.0000602615,0.000009636397,0.0002258463,0.000008535764,0.0001131833,0.9974036,0.0003811437,0.00004756228,0.00123054],"study_design_scores_gemma":[0.0000613278,0.0002368127,0.007929069,0.000007877339,0.00001808324,0.0007371274,0.00002728975,0.001978742,0.9863362,0.0002744922,0.00238631,0.000006625999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849347,0.005208552,0.006408737,0.0003266298,0.00006301849,0.00006479891,0.0002963223,0.0000958661,0.002601403],"genre_scores_gemma":[0.9946601,0.001518599,0.001351672,0.00004457099,0.00002404588,0.00005251656,0.0002068683,0.00000630505,0.002135399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289392,"threshold_uncertainty_score":0.004313469,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1918986430","doi":"10.1073/pnas.1419895112","title":"Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto","funders":"University of North Carolina at Chapel Hill; University of Toronto; Canada Research Chairs; McMaster University; Princess Margaret Cancer Foundation; Canada Foundation for Innovation; Canadian Cancer Society Research Institute; Cancer Research Society","keywords":"Effector; Mutation; Binding site; Cancer research; Cell biology; Genetics; Chemistry; Computational biology; Biology; Gene","authors":[{"name":"Mohammad T. Mazhab‐Jafari","is_ca":true},{"name":"Christopher B. Marshall","is_ca":true},{"name":"Matthew J. Smith","is_ca":true},{"name":"Geneviève M. C. Gasmi-Seabrook","is_ca":true},{"name":"Peter B. Stathopulos","is_ca":true},{"name":"Fuyuhiko Inagaki","is_ca":false},{"name":"Lewis E. Kay","is_ca":true},{"name":"Benjamin G. Neel","is_ca":true},{"name":"Mitsuhiko Ikura","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02335727718485846,"gpt":0.2839330480568619,"spread":0.2605757708720035,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006464187,0.0002174459,0.0001465447,0.0000625857,0.0001139609,0.0001255775,0.000203238,0.0001863512,0.0008385346],"category_scores_gemma":[0.00009885393,0.000119145,0.0001817736,0.00006763377,0.0002226967,0.0001403565,0.0002451424,0.0003304223,0.0002008724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002444877,"about_ca_system_score_gemma":0.0001211503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008718569,"about_ca_topic_score_gemma":0.0009260883,"domain_scores_codex":[0.9999106,0.00001623293,0.000007708083,0.00001767144,0.00002830263,0.00001952269],"domain_scores_gemma":[0.9999396,0.00001191908,0.00002087501,0.0000062443,0.000005288771,0.00001622105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005686338,0.000009323103,0.00005010892,0.00001429881,0.000004350913,0.00002308005,0.000008340376,0.0000454125,0.999518,0.00006725912,0.00001089098,0.0001919892],"study_design_scores_gemma":[0.00001367495,0.0001004164,0.001349894,0.000003005913,0.00000829729,0.0001087186,0.00002400436,0.001140023,0.9959538,0.00003019234,0.0012629,0.000005107295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985768,0.0002024181,0.0007328065,0.00002732884,0.000009845328,0.000005257225,0.0000628255,0.00001743577,0.0003652188],"genre_scores_gemma":[0.9985557,0.0001222268,0.0006115133,0.00001862095,0.000001739394,0.000006090908,0.00009610417,0.00000925212,0.0005786826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008718569,"threshold_uncertainty_score":0.002805233,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2091450174","doi":"10.1038/nature12396","title":"Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling","year":2013,"lang":"en","type":"article","venue":"Nature","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":222,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute","keywords":"PTPN11; Biology; Population; Cancer research; Juvenile myelomonocytic leukemia; Cell biology; Pathology; Genetics; Haematopoiesis; Stem cell; Medicine; Mutation","authors":[{"name":"Wentian Yang","is_ca":false},{"name":"Jianguo Wang","is_ca":false},{"name":"Douglas C. Moore","is_ca":false},{"name":"Haipei Liang","is_ca":false},{"name":"Mark S. Dooner","is_ca":false},{"name":"Qian Wu","is_ca":false},{"name":"Richard M. Terek","is_ca":false},{"name":"Qian Chen","is_ca":false},{"name":"Michael G. Ehrlich","is_ca":false},{"name":"Peter J. Quesenberry","is_ca":false},{"name":"Benjamin G. Neel","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006398798540628004,"gpt":0.2359925944605991,"spread":0.2295937959199711,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011801,0.0005912312,0.0002929137,0.0004311748,0.0003520258,0.000430771,0.0006056423,0.0007313336,0.002677784],"category_scores_gemma":[0.0002409351,0.0003984029,0.0004057584,0.0002130061,0.0005168765,0.000190265,0.0005788167,0.001062717,0.0006470538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064338,"about_ca_system_score_gemma":0.0002905523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006958264,"about_ca_topic_score_gemma":0.001536427,"domain_scores_codex":[0.9997982,0.00001826009,0.00002996455,0.00004523779,0.00006495172,0.00004338634],"domain_scores_gemma":[0.9997358,0.00006543995,0.00007833078,0.00002996442,0.00001051937,0.00007999661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002034899,0.0000420576,0.0005496082,0.00002742645,0.00001358125,0.00797995,0.00002569866,0.0001286293,0.9894426,0.0003759322,0.00009079573,0.001120346],"study_design_scores_gemma":[0.0001567326,0.0002745973,0.01694257,0.00001513156,0.0001206667,0.04041021,0.000154389,0.002814176,0.9326717,0.0003926709,0.006019587,0.00002755342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946792,0.0002462982,0.002512531,0.0001217187,0.0000524255,0.00003871993,0.0003897772,0.0001169871,0.001842252],"genre_scores_gemma":[0.9948061,0.0001988774,0.00107797,0.00004416589,0.00001240689,0.0000225962,0.000335011,0.00004837259,0.003454397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002677784,"threshold_uncertainty_score":0.008958101,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1980422861","doi":"10.1038/ni.2246","title":"Protein tyrosine phosphatases in lymphocyte activation and autoimmunity","year":2012,"lang":"en","type":"review","venue":"Nature Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Autoimmunity; Protein tyrosine phosphatase; Cell biology; Biology; Lymphocyte; Signal transduction; Receptor; Intracellular; Immunology; Lymphocyte activation; Immune system; T cell; Biochemistry","authors":[{"name":"Inmoo Rhee","is_ca":true},{"name":"André Veillette","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0169313923649197,"gpt":0.2973480496688399,"spread":0.2804166573039202,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007687279,0.001354654,0.001499351,0.001491592,0.0003187189,0.001128117,0.001204266,0.001671187,0.002274332],"category_scores_gemma":[0.0007553952,0.0004069118,0.0003366115,0.002186626,0.0008646198,0.001647618,0.0009475243,0.002844915,0.00179204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008415061,"about_ca_system_score_gemma":0.001134233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007602206,"about_ca_topic_score_gemma":0.001677343,"domain_scores_codex":[0.9997882,0.00002802094,0.00002814218,0.00003423236,0.00009397631,0.00002753403],"domain_scores_gemma":[0.9997421,0.00009227514,0.00003626389,0.00001066615,0.00007689801,0.00004190061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001444447,0.00007887716,0.0001435969,0.006366333,0.00006432396,0.000276486,0.00003132171,0.000435426,0.003150075,0.005624027,0.07970035,0.9039847],"study_design_scores_gemma":[0.00003455418,0.00003573175,0.0004295476,0.0007225182,0.00007527875,0.0009681283,0.00003021083,0.0001206582,0.0006413848,0.003084869,0.9938427,0.00001427515],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009172864,0.9976081,0.0003174666,0.0004676026,0.0006578137,0.000003410581,0.00001333358,0.0000101899,0.0008302371],"genre_scores_gemma":[0.0007867205,0.996356,0.000339629,0.000331323,0.0009203982,0.000008283038,0.00003096532,0.000002269124,0.001224351],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002274332,"threshold_uncertainty_score":0.007608414,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2129997470","doi":"10.1172/jci59492","title":"T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"National Health and Medical Research Council","keywords":"Protein tyrosine phosphatase; Autoimmunity; T cell; Biology; CD8; Immunology; Proinflammatory cytokine; T-cell receptor; Autoimmune disease; Inflammation; Regulatory T cell; Signal transduction; Cell biology; IL-2 receptor; Antigen; Antibody; Immune system","authors":[{"name":"Florian Wiede","is_ca":false},{"name":"Benjamin J. Shields","is_ca":false},{"name":"S. Chew","is_ca":false},{"name":"Konstantinos Kyparissoudis","is_ca":false},{"name":"Catherine van Vliet","is_ca":false},{"name":"Sandra Galić","is_ca":false},{"name":"Michel L. Tremblay","is_ca":true},{"name":"Sarah M. Russell","is_ca":false},{"name":"Dale I. Godfrey","is_ca":false},{"name":"Tony Tiganis","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04422168076924771,"gpt":0.3068431055594211,"spread":0.2626214247901734,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004395866,0.0008069159,0.0004182148,0.0009121734,0.0003244263,0.0005756987,0.0005266254,0.000906491,0.002277792],"category_scores_gemma":[0.0003240028,0.0004287012,0.0004153395,0.0003222834,0.0007268216,0.0004858303,0.0003320685,0.001965441,0.0007190607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005257624,"about_ca_system_score_gemma":0.0003968456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006431034,"about_ca_topic_score_gemma":0.001000319,"domain_scores_codex":[0.9993483,0.0001308462,0.00006250923,0.0001508762,0.0001606927,0.0001467156],"domain_scores_gemma":[0.9995551,0.00006806044,0.0001352487,0.00006281333,0.00003562014,0.000143175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004246699,0.0002285394,0.0002582477,0.00005454617,0.00001790648,0.000129565,0.00002873721,0.0001830342,0.9950005,0.0005496586,0.0002035624,0.002920941],"study_design_scores_gemma":[0.0003340434,0.001667508,0.002431,0.00003140611,0.00005805618,0.000993578,0.00003453737,0.00332178,0.9831393,0.000456892,0.007521369,0.00001052104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796051,0.003419578,0.01004295,0.0007762974,0.0001670663,0.0001684586,0.0008202072,0.0007180458,0.00428221],"genre_scores_gemma":[0.9813157,0.001931739,0.007267583,0.0002881442,0.00007701589,0.0002638235,0.0008091546,0.0001505095,0.007896417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002277792,"threshold_uncertainty_score":0.007619977,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2152550058","doi":"10.1093/carcin/bgn167","title":"Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells","year":2008,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"University of Hong Kong; Ministry of Education, Culture, Sports, Science and Technology; University of Ottawa","keywords":"Ovarian cancer; Kinase; Cancer research; MAPK/ERK pathway; Biology; Cell growth; Cancer cell; Cancer; Cell biology; Biochemistry","authors":[{"name":"David W. Chan","is_ca":false},{"name":"Vincent W.S. Liu","is_ca":false},{"name":"George S.W. Tsao","is_ca":false},{"name":"Kwok‐Ming Yao","is_ca":false},{"name":"Toru Furukawa","is_ca":false},{"name":"Karen K. L. Chan","is_ca":false},{"name":"Hys Ngan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00860934186035597,"gpt":0.2274322173339891,"spread":0.2188228754736331,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007792734,0.0002461559,0.0002317021,0.0001884198,0.0001489151,0.0002273133,0.0001205047,0.0002036457,0.0009032553],"category_scores_gemma":[0.00007877565,0.0001248542,0.0002412813,0.0001772854,0.0002045676,0.0001566156,0.0002145319,0.0005647113,0.0001953376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548477,"about_ca_system_score_gemma":0.0002070608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006747398,"about_ca_topic_score_gemma":0.0007866754,"domain_scores_codex":[0.999918,0.000009819752,0.000008601251,0.00001262563,0.00002591323,0.00002508332],"domain_scores_gemma":[0.9999496,0.000006771525,0.00001542089,0.000006780099,0.000005531171,0.00001599782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009536073,0.00002562593,0.0002590214,0.00002925479,0.000005851037,0.00005931029,0.00001611421,0.00005851888,0.9984938,0.00008329998,0.00004680363,0.0008270661],"study_design_scores_gemma":[0.00002869222,0.0002675293,0.009060035,0.000004303269,0.00002398473,0.0005011361,0.00002902421,0.001563639,0.9859574,0.00009645238,0.002462865,0.000005017821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968079,0.0007408204,0.00126845,0.000102436,0.00001863972,0.00001881137,0.0002246525,0.00008480556,0.0007334919],"genre_scores_gemma":[0.9984245,0.0002483383,0.000407374,0.00002905497,0.000003305982,0.00001531983,0.0001925455,0.000007531986,0.000672045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009032553,"threshold_uncertainty_score":0.003021657,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2035109614","doi":"10.1038/sj.gene.6364159","title":"The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status","year":2004,"lang":"en","type":"article","venue":"Genes and Immunity","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Abbott Laboratories","keywords":"PTPN22; Rheumatoid arthritis; Allele; Single-nucleotide polymorphism; Biology; Immunology; Rheumatoid factor; Internal medicine; Genetics; Genotype; Medicine; Gene","authors":[{"name":"A T Lee","is_ca":false},{"name":"Wentian Li","is_ca":false},{"name":"Anthony Liew","is_ca":false},{"name":"Claire Bombardier","is_ca":true},{"name":"Michael H. Weisman","is_ca":false},{"name":"Elena Massarotti","is_ca":false},{"name":"J Kent","is_ca":false},{"name":"Frederick Wolfe","is_ca":false},{"name":"A. B. Begovich","is_ca":false},{"name":"Peter K. Gregersen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006078909858840812,"gpt":0.2106664061533539,"spread":0.204587496294513,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007436962,0.0008040518,0.000764607,0.001286396,0.0003768658,0.0004488738,0.0004964598,0.0007799185,0.006241404],"category_scores_gemma":[0.001925431,0.0005874786,0.0008643813,0.0006953965,0.0005621274,0.0003391989,0.0004219687,0.0009442582,0.001327724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123414,"about_ca_system_score_gemma":0.00012853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003252237,"about_ca_topic_score_gemma":0.0003101557,"domain_scores_codex":[0.9991869,0.0003745241,0.0000635758,0.0001725739,0.0001370172,0.00006536816],"domain_scores_gemma":[0.9968347,0.001164877,0.00099397,0.0004975662,0.0001349225,0.0003740367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006636336,0.0007405811,0.360402,0.000161117,0.001120667,0.004123372,0.000269274,0.0003127813,0.6171169,0.0002571017,0.0004325735,0.008427356],"study_design_scores_gemma":[0.00008533607,0.001656157,0.9684685,0.00001645121,0.00047303,0.009862525,0.0000833281,0.0005597247,0.01772462,0.0001700769,0.0008800342,0.0000201935],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966428,0.0006486345,0.0009201374,0.00008256298,0.00003740469,0.00001246122,0.0001802461,0.00006162759,0.00141401],"genre_scores_gemma":[0.9968106,0.0002125736,0.0002610031,0.00003321483,0.0000507466,0.00001416019,0.0001560575,0.00003729923,0.002424309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006241404,"threshold_uncertainty_score":0.02087963,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2743219260","doi":"10.1016/j.biopsych.2017.07.023","title":"A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer’s Disease","year":2017,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":203,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre hospitalier universitaire de Québec; University of British Columbia; Université Laval","funders":"Program for Changjiang Scholars and Innovative Research Team in University; Fonds de Recherche du Québec - Santé; Huazhong University of Science and Technology; National Natural Science Foundation of China","keywords":"Synaptic plasticity; Biology; Neuroscience; Long-term potentiation; Neurotransmission; Cell biology; Hippocampus; Gene silencing; Receptor; Biochemistry","authors":[{"name":"Xiong Wang","is_ca":false},{"name":"Dan Liu","is_ca":false},{"name":"He‐Zhou Huang","is_ca":false},{"name":"Zhihao Wang","is_ca":false},{"name":"Tongyao Hou","is_ca":false},{"name":"Xin Yang","is_ca":false},{"name":"Pei Pang","is_ca":false},{"name":"Na Wei","is_ca":false},{"name":"Yafan Zhou","is_ca":false},{"name":"Marie-Josée Dupras","is_ca":true},{"name":"Frédéric Calon","is_ca":true},{"name":"Heng‐Ye Man","is_ca":false},{"name":"Jianguo Chen","is_ca":false},{"name":"Jian‐Zhi Wang","is_ca":false},{"name":"Sébastien Hébert","is_ca":true},{"name":"Youming Lu","is_ca":false},{"name":"Ling‐Qiang Zhu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02887816932114064,"gpt":0.2675774737639381,"spread":0.2386993044427975,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002483537,0.0006204785,0.0004433419,0.0002939661,0.0003283131,0.0003246837,0.0004806806,0.0005812418,0.00102903],"category_scores_gemma":[0.0002621986,0.000231563,0.0004349126,0.0001130824,0.0004632847,0.0003082276,0.0003687032,0.0007575091,0.0003037358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004644069,"about_ca_system_score_gemma":0.0002835077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005455293,"about_ca_topic_score_gemma":0.0007051844,"domain_scores_codex":[0.9998499,0.00002309194,0.00001740045,0.00004950229,0.00003270335,0.00002743131],"domain_scores_gemma":[0.9998688,0.00001086057,0.00005593968,0.0000116677,0.00001595861,0.00003687404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008232766,0.0001164396,0.001850492,0.00009004547,0.00007314196,0.002590871,0.00003120105,0.0001572753,0.9889025,0.0006954244,0.0003089938,0.004360297],"study_design_scores_gemma":[0.0007760836,0.001489762,0.1232194,0.00006376897,0.0008164127,0.02173415,0.0002316328,0.01162929,0.8287069,0.004221494,0.00704116,0.00006997403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993137,0.001799475,0.003227058,0.000241221,0.00008368499,0.00003667408,0.0001856256,0.0000897137,0.001199611],"genre_scores_gemma":[0.9973856,0.0004078799,0.001191323,0.00009297851,0.00001824633,0.00002772903,0.000137981,0.00001351981,0.0007249645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102903,"threshold_uncertainty_score":0.003442526,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2018012729","doi":"10.1007/s10555-008-9121-3","title":"PRL PTPs: mediators and markers of cancer progression","year":2008,"lang":"en","type":"review","venue":"Cancer and Metastasis Reviews","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Protein tyrosine phosphatase; Metastasis; Cancer; Tumor progression; Cancer research; Biology; Biomarker; Colorectal cancer; Tyrosine phosphorylation; Phosphorylation; Cell biology; Biochemistry; Genetics","authors":[{"name":"Darrell C. Bessette","is_ca":true},{"name":"Dexin Qiu","is_ca":true},{"name":"Catherine J. Pallen","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04236811890434106,"gpt":0.3883666563809811,"spread":0.3459985374766401,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001228627,0.001408291,0.001847127,0.001981363,0.0003828147,0.001685594,0.001483282,0.001823609,0.002141534],"category_scores_gemma":[0.001101677,0.0005521257,0.0004229346,0.002755196,0.001398183,0.001990292,0.0009665838,0.003418168,0.002384044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001197819,"about_ca_system_score_gemma":0.001246043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009893506,"about_ca_topic_score_gemma":0.001890455,"domain_scores_codex":[0.9996641,0.00004991753,0.0000362285,0.00005636741,0.0001577744,0.00003564636],"domain_scores_gemma":[0.9995337,0.0001967655,0.00006062165,0.00001671589,0.0001351452,0.00005714909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000164317,0.00005866228,0.0004091105,0.005517643,0.00008306829,0.0003291263,0.00007218379,0.0005793477,0.00556996,0.009257597,0.06120149,0.9167575],"study_design_scores_gemma":[0.0000413257,0.00005386717,0.0006957613,0.0005677179,0.00006402976,0.001305,0.00006050491,0.0001263587,0.001064443,0.004636837,0.9913645,0.00001971107],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000829041,0.9982747,0.0003314115,0.0003883596,0.0003949269,0.000003362333,0.00001255002,0.00001018484,0.0005015938],"genre_scores_gemma":[0.0007749287,0.9973606,0.0002930631,0.0002389985,0.0004772724,0.000009137786,0.00002785322,0.00000131177,0.0008167482],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002141534,"threshold_uncertainty_score":0.008690774,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2054519090","doi":"10.1038/ng.2900","title":"Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma","year":2014,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Biology; Lymphoma; Missense mutation; Cancer research; T-cell lymphoma; Frameshift mutation; Mutation; Gene; Genetics; Immunology","authors":[{"name":"Jay Gunawardana","is_ca":true},{"name":"Fong Chun Chan","is_ca":true},{"name":"Adèle Telenius","is_ca":true},{"name":"Bruce W. Woolcock","is_ca":true},{"name":"Robert Kridel","is_ca":true},{"name":"King Tan","is_ca":true},{"name":"Susana Ben‐Neriah","is_ca":true},{"name":"Anja Mottok","is_ca":true},{"name":"Raymond S. Lim","is_ca":true},{"name":"Merrill Boyle","is_ca":true},{"name":"Sanja Rogić","is_ca":true},{"name":"Lisa M. Rimsza","is_ca":false},{"name":"Chrystelle Guiter","is_ca":false},{"name":"Karen Leroy","is_ca":false},{"name":"Philippe Gaulard","is_ca":false},{"name":"Corinne Haïoun","is_ca":false},{"name":"Marco A. Marra","is_ca":true},{"name":"Kerry J. Savage","is_ca":true},{"name":"Joseph M. Connors","is_ca":true},{"name":"Sohrab P. Shah","is_ca":true},{"name":"Randy D. Gascoyne","is_ca":true},{"name":"Christian Steidl","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004193126112541316,"gpt":0.2265253020102247,"spread":0.2223321758976834,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002175326,0.0002461768,0.0002332739,0.0008605004,0.0002378817,0.0003866089,0.0002886122,0.0005293997,0.001619724],"category_scores_gemma":[0.001085703,0.0002108406,0.0001584495,0.0005215575,0.0004033154,0.0002365414,0.0004130707,0.0002301044,0.0003096649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004061933,"about_ca_system_score_gemma":0.0001610834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008633347,"about_ca_topic_score_gemma":0.0008904698,"domain_scores_codex":[0.9998114,0.00001840096,0.00002815233,0.00004039132,0.00006647208,0.00003530386],"domain_scores_gemma":[0.9996557,0.00009320996,0.000106174,0.00002808081,0.00002799834,0.00008878487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001776861,0.0001231667,0.2854149,0.0001824827,0.0001120248,0.1794469,0.000784952,0.0009182035,0.5063638,0.0006336749,0.0007029976,0.02353998],"study_design_scores_gemma":[0.0001083613,0.0003385716,0.5523168,0.00001880866,0.0002051061,0.3912817,0.0004467916,0.002156725,0.05034215,0.0006507362,0.002103505,0.00003067961],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986818,0.000329468,0.0001403911,0.00002943341,0.000006471158,0.000003381704,0.00004561923,0.00001096579,0.0007525835],"genre_scores_gemma":[0.9996586,0.00007974579,0.0000738786,0.000007347279,0.000008822017,0.000001192108,0.00003234477,0.000002372544,0.0001357611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619724,"threshold_uncertainty_score":0.005418539,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2118738797","doi":"10.1128/mcb.23.6.2017-2028.2003","title":"Phosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor","year":2003,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; McGill University","funders":"Wellcome Trust","keywords":"Phosphorylation; Biology; Tyrosine phosphorylation; Lipid raft; Jurkat cells; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; Dephosphorylation; Tyrosine; Signal transducing adaptor protein; Signal transduction; Tyrosine-protein kinase CSK; Tyrosine kinase; T-cell receptor; Molecular biology; Biochemistry; SH2 domain; T cell; Phosphatase; Immunology","authors":[{"name":"Dominique Davidson","is_ca":false},{"name":"Marcin Bakinowski","is_ca":false},{"name":"Matthew L. Thomas","is_ca":false},{"name":"Václav Hořejšı́","is_ca":false},{"name":"André Veillette","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004401983201820665,"gpt":0.196142087063875,"spread":0.1917401038620543,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000634196,0.0003072972,0.0001235198,0.0001395311,0.0001179373,0.0002576186,0.0001401658,0.0001524831,0.0006650232],"category_scores_gemma":[0.0000904863,0.00006958598,0.0001737109,0.0001201517,0.0001664316,0.0001531049,0.0001703322,0.0003821431,0.0002538413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001986015,"about_ca_system_score_gemma":0.0001195379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003013771,"about_ca_topic_score_gemma":0.0003424849,"domain_scores_codex":[0.9999021,0.00001452472,0.000008541427,0.00001762058,0.00001752497,0.00003963061],"domain_scores_gemma":[0.9999467,0.000009442132,0.00001429134,0.000005386018,0.000006100998,0.00001802904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007109917,0.00001419427,0.0001277953,0.00002173765,0.000001976177,0.00004455901,0.000006409949,0.00003757552,0.9988617,0.00004788455,0.00001523786,0.000749872],"study_design_scores_gemma":[0.00001958852,0.0001557357,0.006996754,0.000003469795,0.0000125057,0.0002413322,0.00001370615,0.001316247,0.9903141,0.00004389716,0.0008790659,0.000003607614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996624,0.001374188,0.0009185217,0.0000381583,0.00001178894,0.00001540706,0.0001450661,0.00003357934,0.0008393967],"genre_scores_gemma":[0.9984395,0.0005354065,0.0003958051,0.0000179273,0.000005614724,0.00001479973,0.0001521197,0.000005547448,0.0004332153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006650232,"threshold_uncertainty_score":0.002224684,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2070366486","doi":"10.1016/j.bbapap.2009.09.018","title":"The two faces of PTP1B in cancer","year":2009,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cancer; Context (archaeology); Carcinogenesis; Protein tyrosine phosphatase; Biology; Function (biology); Transmembrane protein; Cancer research; Computational biology; Bioinformatics; Signal transduction; Cell biology; Biochemistry; Genetics; Receptor","authors":[{"name":"Laurent Lessard","is_ca":true},{"name":"Matthew Stuible","is_ca":true},{"name":"Michel L. Tremblay","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02672096152505945,"gpt":0.3408160012070615,"spread":0.3140950396820021,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009976974,0.0008270686,0.001849481,0.001479085,0.0003691067,0.001177337,0.001324817,0.002290461,0.002280237],"category_scores_gemma":[0.0008732029,0.0004393692,0.0003681637,0.001740754,0.00115782,0.002381428,0.001240685,0.003171718,0.001735533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00106792,"about_ca_system_score_gemma":0.001053217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171363,"about_ca_topic_score_gemma":0.002190069,"domain_scores_codex":[0.9997388,0.00003940324,0.00003838987,0.00004769001,0.0001051989,0.00003054479],"domain_scores_gemma":[0.9997042,0.0001179882,0.00004172651,0.00001249392,0.00007902127,0.00004457057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001897975,0.00005164348,0.0002138306,0.007313576,0.00007631968,0.0005695937,0.00007192718,0.0003476175,0.002899229,0.006840224,0.05147997,0.9299464],"study_design_scores_gemma":[0.00005409796,0.00006557437,0.0007124864,0.001547198,0.00007673085,0.002461342,0.00005953029,0.0001311937,0.0006376055,0.004874327,0.9893566,0.00002331524],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006944379,0.9987556,0.0001263586,0.0005415851,0.0002182989,0.000001428643,0.000005421184,0.000003488646,0.0002784635],"genre_scores_gemma":[0.0007283005,0.9976187,0.0002025256,0.0004211562,0.0004502446,0.000004160849,0.00001722965,0.000001070036,0.0005565604],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002290461,"threshold_uncertainty_score":0.007748365,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2938096285","doi":"10.3390/ijms20081803","title":"The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis","year":2019,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Research Foundation of Korea; Burroughs Wellcome Fund; Massachusetts General Hospital; National Research Foundation; Université Laval; National Institutes of Health; March of Dimes Foundation","keywords":"MAPK/ERK pathway; Kinase; Osteoblast; Cell biology; Endocrinology; Internal medicine; Signal transduction; Biology; Chemistry; Cancer research; Medicine; Biochemistry","authors":[{"name":"Jung‐Min Kim","is_ca":false},{"name":"Yeon-Suk Yang","is_ca":false},{"name":"Kwang Hwan Park","is_ca":false},{"name":"Hwanhee Oh","is_ca":false},{"name":"Matthew B. Greenblatt","is_ca":false},{"name":"Jae‐Hyuck Shim","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007607191701723866,"gpt":0.2656400309478039,"spread":0.25803283924608,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387443,0.0005510419,0.0002344065,0.0002524588,0.0004322995,0.0004278498,0.0002603845,0.0003077786,0.002157304],"category_scores_gemma":[0.0001712319,0.0001843494,0.0002586744,0.0001499585,0.0002213501,0.000230138,0.0004427934,0.0005065976,0.001463613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997112,"about_ca_system_score_gemma":0.0006042093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007535898,"about_ca_topic_score_gemma":0.0009722724,"domain_scores_codex":[0.9998216,0.00002053723,0.00001549687,0.00004372897,0.00006240026,0.0000362217],"domain_scores_gemma":[0.9998715,0.000009704101,0.00003962777,0.00001095815,0.00003582424,0.00003241108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003091447,0.00005892292,0.001911171,0.0003926979,0.00003298242,0.0006073704,0.00003723945,0.0003293491,0.9668425,0.001805391,0.001725827,0.02594743],"study_design_scores_gemma":[0.00007909815,0.0004361756,0.079294,0.0001379158,0.00008595322,0.005746413,0.0001501517,0.003145182,0.7728575,0.00247247,0.1355352,0.000059874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8752295,0.05144458,0.02901913,0.002249878,0.0006569093,0.0001701546,0.007893507,0.002262759,0.03107356],"genre_scores_gemma":[0.9548807,0.01342207,0.007160884,0.0002357479,0.00006836234,0.0001021585,0.003310847,0.0001068268,0.02071228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157304,"threshold_uncertainty_score":0.007216871,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2121921857","doi":"10.1146/annurev.immunol.23.021704.115647","title":"Nonreceptor Protein-Tyrosine Phosphatases in Immune Cell Signaling","year":2007,"lang":"en","type":"review","venue":"Annual Review of Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Protein tyrosine phosphatase; Biology; Phosphorylation; Immune system; Signal transduction; Innate immune system; Cell biology; Tyrosine phosphorylation; Tyrosine; Phosphatase; Protein phosphorylation; Cell signaling; Receptor tyrosine kinase; Kinase; Tyrosine kinase; Cell; Biochemistry; Protein kinase A; Immunology","authors":[{"name":"Lily Pao","is_ca":false},{"name":"Karen Badour","is_ca":true},{"name":"Katherine Siminovitch","is_ca":true},{"name":"Benjamin G. Neel","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0171862174543357,"gpt":0.3168730968807855,"spread":0.2996868794264498,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005256688,0.001192261,0.00135897,0.001277099,0.0003561056,0.00078904,0.001062725,0.001109686,0.002986639],"category_scores_gemma":[0.0003180866,0.0002464823,0.0003192982,0.001967619,0.0005427377,0.001411671,0.0006671962,0.001611276,0.005531326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008091739,"about_ca_system_score_gemma":0.0008616097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005559861,"about_ca_topic_score_gemma":0.0007653263,"domain_scores_codex":[0.9997821,0.00003118484,0.00002182745,0.00003911522,0.0001016746,0.00002407031],"domain_scores_gemma":[0.9998598,0.00003419937,0.00002112439,0.000005914655,0.00004748556,0.00003147848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006401071,0.00007148705,0.0002109639,0.00594877,0.00005201761,0.0005014703,0.00005549077,0.0004490134,0.008990316,0.007029242,0.03496134,0.9416659],"study_design_scores_gemma":[0.00001629034,0.00005826949,0.000720443,0.0005590954,0.00003482906,0.001866747,0.0000375147,0.00009348115,0.001140917,0.003631806,0.9918293,0.00001136255],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001511087,0.9977186,0.0002910303,0.0001976609,0.0002822113,0.000004126189,0.000008061855,0.00001148533,0.001335803],"genre_scores_gemma":[0.00113125,0.9965753,0.0003204821,0.0001356185,0.0002963771,0.000005959303,0.0000230049,0.000001479084,0.00151053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002986639,"threshold_uncertainty_score":0.009991288,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}