{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":47,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":47,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"c2162fb467e9","filters":{"venue":"Blood Cancer Discovery"}},"results":[{"id":"W2999773798","doi":"10.1158/0008-5472.bcd-19-0041","title":"Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; KWF Kankerbestrijding; China Scholarship Council","keywords":"Lymphoblastic Leukemia; Somatic evolution in cancer; Cancer research; Medicine; Biology; Leukemia; Genetics; Oncology; Gene","authors":[{"name":"Esmé Waanders","is_ca":false},{"name":"Zhaohui Gu","is_ca":false},{"name":"Stephanie M. Dobson","is_ca":true},{"name":"Željko Antić","is_ca":false},{"name":"Jeremy Chase Crawford","is_ca":false},{"name":"Xiaotu Ma","is_ca":false},{"name":"Michael N. Edmonson","is_ca":false},{"name":"Debbie Payne-Turner","is_ca":false},{"name":"Maartje van de Vorst","is_ca":false},{"name":"Marjolijn C.J. Jongmans","is_ca":false},{"name":"Irina McGuire","is_ca":false},{"name":"Xin Zhou","is_ca":false},{"name":"Wang Jian","is_ca":false},{"name":"Lei Shi","is_ca":false},{"name":"Stanley Pounds","is_ca":false},{"name":"Deqing Pei","is_ca":false},{"name":"Cheng Cheng","is_ca":false},{"name":"Guangchun Song","is_ca":false},{"name":"Yiping Fan","is_ca":false},{"name":"Ying Shao","is_ca":false},{"name":"Michael Rusch","is_ca":false},{"name":"Kelly McCastlain","is_ca":false},{"name":"Jiangyan Yu","is_ca":false},{"name":"Ruben van Boxtel","is_ca":false},{"name":"Francis Blokzijl","is_ca":false},{"name":"Ilaria Iacobucci","is_ca":false},{"name":"Kathryn G. Roberts","is_ca":false},{"name":"Ji Wen","is_ca":false},{"name":"Gang Wu","is_ca":false},{"name":"Jing Ma","is_ca":false},{"name":"John Easton","is_ca":false},{"name":"Geoffrey Neale","is_ca":false},{"name":"Scott R. Olsen","is_ca":false},{"name":"Kim E. Nichols","is_ca":false},{"name":"Ching‐Hon Pui","is_ca":false},{"name":"Jinghui Zhang","is_ca":false},{"name":"William E. Evans","is_ca":false},{"name":"Mary V. Relling","is_ca":false},{"name":"Jun J. Yang","is_ca":false},{"name":"Paul G. Thomas","is_ca":false},{"name":"John E. Dick","is_ca":true},{"name":"Roland P. Kuiper","is_ca":false},{"name":"Charles G. Mullighan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0106784456143328,"gpt":0.258021045144686,"spread":0.2473425995303533,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002323321,0.00008126064,0.0001170925,0.0007400556,0.000107015,0.0002667318,0.0001535096,0.000137848,0.0005232056],"category_scores_gemma":[0.0004041751,0.00007796406,0.00007109333,0.0003794833,0.0001769677,0.0001446171,0.0002060889,0.0001217926,0.00009143913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251317,"about_ca_system_score_gemma":0.00006372247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005059055,"about_ca_topic_score_gemma":0.0007689038,"domain_scores_codex":[0.9998616,0.00002878272,0.000008463774,0.00003441564,0.00003858417,0.00002806718],"domain_scores_gemma":[0.9998102,0.00004964508,0.00006811625,0.00002124694,0.00003198444,0.00001888651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007225919,0.00005083126,0.4393528,0.00006869013,0.00004462877,0.0007878672,0.0003952942,0.001680803,0.5245363,0.0004587811,0.0001478234,0.03175371],"study_design_scores_gemma":[0.00001391087,0.0003729628,0.9265276,0.00000900688,0.000047226,0.005259653,0.0003780714,0.007415874,0.05775239,0.0004638641,0.001747847,0.00001164031],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991568,0.0001816109,0.0003653482,0.000005784658,3.476807e-7,0.000004416291,0.00008291661,0.00001137093,0.0001914098],"genre_scores_gemma":[0.9993332,0.0000771894,0.0003584786,0.000005052436,8.492293e-7,0.000004288965,0.0001423722,0.000003520709,0.00007506353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007400556,"threshold_uncertainty_score":0.00175029,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4387128075","doi":"10.1158/2643-3230.bcd-23-0049","title":"IVIg Use Associated with Ten-Fold Reduction of Serious Infections in Multiple Myeloma Patients Treated with Anti-BCMA Bispecific Antibodies","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"Narodowa Agencja Wymiany Akademickiej","keywords":"Hypogammaglobulinemia; Medicine; Antibody; Multiple myeloma; Internal medicine; Immunology; Confidence interval; Cumulative incidence; Incidence (geometry); Gastroenterology; Cohort","authors":[{"name":"Guido Lancman","is_ca":true},{"name":"Kian Parsa","is_ca":false},{"name":"Krzysztof Kotlarz","is_ca":false},{"name":"Lisa Avery","is_ca":true},{"name":"Alaina Lurie","is_ca":false},{"name":"Alex Lieberman-Cribbin","is_ca":false},{"name":"Hearn Jay Cho","is_ca":false},{"name":"Samir Parekh","is_ca":false},{"name":"Shambavi Richard","is_ca":false},{"name":"Joshua Richter","is_ca":false},{"name":"Cesar Rodriguez","is_ca":false},{"name":"Adriana Rossi","is_ca":false},{"name":"Larysa Sanchez","is_ca":false},{"name":"Santiago Thibaud","is_ca":false},{"name":"Sundar Jagannath","is_ca":false},{"name":"Ajai Chari","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0270653576593723,"gpt":0.2764829583594968,"spread":0.2494176007001245,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003277177,0.000192826,0.0003613781,0.0001449356,0.0001132386,0.0003181233,0.0001020582,0.0001823374,0.0005084898],"category_scores_gemma":[0.001378967,0.00006620771,0.0003224915,0.0001847442,0.0001020933,0.0001481955,0.0001639925,0.0005096926,0.0000516568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194472,"about_ca_system_score_gemma":0.0002569415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000325691,"about_ca_topic_score_gemma":0.0004206073,"domain_scores_codex":[0.9996765,0.0001067993,0.00003997757,0.00004765626,0.00006952551,0.00005966761],"domain_scores_gemma":[0.9992489,0.0001714445,0.0003775829,0.00004442173,0.00005295342,0.0001045844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00784923,0.0005828718,0.8779571,0.000197811,0.0004878299,0.0006478553,0.0001592676,0.0004226285,0.02244703,0.00006820082,0.0004487401,0.08873135],"study_design_scores_gemma":[0.00007555317,0.005625778,0.9861157,0.00002635585,0.000349466,0.001414712,0.00008005525,0.0004660935,0.004282743,0.00005119799,0.001505391,0.000006935883],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971688,0.002133391,0.0001804157,0.00005266318,0.00001381673,0.00001401276,0.00005638233,0.00001414709,0.0003663143],"genre_scores_gemma":[0.9995509,0.0001918075,0.00006865089,0.00003049891,0.000008875468,0.000004244966,0.00004692133,0.000001130325,0.00009694715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005084898,"threshold_uncertainty_score":0.001733184,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3200480347","doi":"10.1158/2643-3230.bcd-20-0208","title":"NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity","year":2021,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; Parker Institute for Cancer Immunotherapy; Entertainment Industry Foundation; Cancer Research Institute; Burroughs Wellcome Fund; Stanford Maternal and Child Health Research Institute; American Association for Cancer Research","keywords":"Haematopoiesis; Progenitor cell; Proinflammatory cytokine; Cancer research; CD34; Endothelial stem cell; Stem cell; Bone marrow; Myeloid; Immunology; Biology; In vitro; Cell biology; Inflammation","authors":[{"name":"Rebecca M. Richards","is_ca":false},{"name":"Feifei Zhao","is_ca":false},{"name":"Katherine A. Freitas","is_ca":false},{"name":"Kevin R. Parker","is_ca":false},{"name":"Peng Xu","is_ca":false},{"name":"Amy C. Fan","is_ca":false},{"name":"Elena Sotillo","is_ca":false},{"name":"Mads Daugaard","is_ca":true},{"name":"Htoo Zarni Oo","is_ca":true},{"name":"Jie Liu","is_ca":false},{"name":"Wan‐Jen Hong","is_ca":false},{"name":"Poul H. Sorensen","is_ca":true},{"name":"Howard Y. Chang","is_ca":false},{"name":"Ansuman T. Satpathy","is_ca":false},{"name":"Robbie G. Majzner","is_ca":false},{"name":"Ravindra Majeti","is_ca":false},{"name":"Crystal L. Mackall","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01625178464506925,"gpt":0.3011283694173624,"spread":0.2848765847722931,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770184,0.0003104572,0.0003228078,0.0001345262,0.0001787366,0.0006536199,0.0003252637,0.0005224058,0.001879438],"category_scores_gemma":[0.0001668299,0.0001172646,0.0001452008,0.0001684429,0.0003671122,0.0002917698,0.0002927023,0.001234118,0.0006309156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658173,"about_ca_system_score_gemma":0.0002897926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004016535,"about_ca_topic_score_gemma":0.0008748689,"domain_scores_codex":[0.9997516,0.00003649704,0.00001120245,0.00005620862,0.00009832488,0.00004616664],"domain_scores_gemma":[0.9999303,0.0000162423,0.00001337495,0.000007877068,0.00001801668,0.00001428901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414047,0.00006279108,0.0001236407,0.00007962579,0.00001024849,0.0001224057,0.00002107611,0.0005985804,0.9796748,0.002187705,0.003804065,0.01307374],"study_design_scores_gemma":[0.00004389708,0.0003272962,0.0006271623,0.000009807531,0.00002738693,0.0002550231,0.00002528548,0.001900604,0.9554324,0.0007594996,0.04058047,0.0000112041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8197097,0.0273635,0.1043997,0.01023284,0.002464571,0.0004650907,0.002093882,0.002024947,0.03124576],"genre_scores_gemma":[0.9487843,0.009594048,0.01388712,0.00260328,0.0003306145,0.0001489051,0.0007482941,0.0001909918,0.0237125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879438,"threshold_uncertainty_score":0.006287277,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4409872473","doi":"10.1158/2643-3230.bcd-24-0342","title":"Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Canada First Research Excellence Fund; Terry Fox Foundation; International Development Research Centre; National Cancer Institute; University of Toronto; Canadian Cancer Society; Government of Ontario; Princess Margaret Cancer Foundation; St. Jude Children's Research Hospital; American Lebanese Syrian Associated Charities; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Atlas (anatomy); Haematopoiesis; Biology; Hierarchy; Genetics; Computational biology; Evolutionary biology; Stem cell; Political science","authors":[{"name":"Andy G.X. Zeng","is_ca":true},{"name":"Ilaria Iacobucci","is_ca":false},{"name":"Sayyam Shah","is_ca":true},{"name":"Amanda Mitchell","is_ca":true},{"name":"Gordon Wong","is_ca":true},{"name":"Suraj Bansal","is_ca":true},{"name":"David Chen","is_ca":true},{"name":"Qingsong Gao","is_ca":false},{"name":"Hyerin Kim","is_ca":true},{"name":"James A. Kennedy","is_ca":true},{"name":"Andrea Arruda","is_ca":true},{"name":"Mark D. Minden","is_ca":true},{"name":"Torsten Haferlach","is_ca":false},{"name":"Charles G. Mullighan","is_ca":false},{"name":"John E. Dick","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02081339611851763,"gpt":0.2909054888823361,"spread":0.2700920927638185,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007307578,0.0001758733,0.0003441477,0.0007679881,0.0003178011,0.0009426725,0.0004409056,0.0003861089,0.001050726],"category_scores_gemma":[0.001099727,0.0001912295,0.0003688568,0.001232826,0.0005062649,0.0004770456,0.0006488261,0.0009046847,0.000456723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007447728,"about_ca_system_score_gemma":0.0005630197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002153066,"about_ca_topic_score_gemma":0.006862819,"domain_scores_codex":[0.9996574,0.00005790871,0.00001867929,0.0001307104,0.0001087807,0.00002643884],"domain_scores_gemma":[0.9993905,0.000205078,0.00004867398,0.0001460024,0.0001655499,0.00004405588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005452909,0.00003397635,0.02741269,0.0008309549,0.0002813287,0.0003337753,0.001012919,0.01554634,0.6306167,0.0386826,0.05580591,0.2288975],"study_design_scores_gemma":[0.00004746737,0.0002470107,0.1395445,0.0002368714,0.0003425018,0.001699806,0.0007375566,0.0381275,0.2930289,0.04854011,0.477241,0.0002067354],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5031349,0.04040233,0.3563616,0.02305679,0.001613279,0.0001153726,0.04967798,0.006141168,0.01949656],"genre_scores_gemma":[0.8302921,0.01929762,0.1185206,0.004067122,0.0005817718,0.000162835,0.01737444,0.0007977917,0.008905694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002153066,"threshold_uncertainty_score":0.005403757,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3108186512","doi":"10.1158/2643-3230.bcd-20-0155","title":"Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; Canadian Cancer Society; Wellcome Trust","keywords":"Haematopoiesis; Myeloid leukemia; Myelopoiesis; Myeloid; Stem cell; Biology; Immunology; Cancer research; Leukemia; Regulator; Hematopoietic stem cell; Cell biology; Inflammation; Genetics; Gene","authors":[{"name":"Stephanie Z. Xie","is_ca":true},{"name":"Kerstin B. Kaufmann","is_ca":true},{"name":"Weijia Wang","is_ca":false},{"name":"Michelle Chan‐Seng‐Yue","is_ca":true},{"name":"Olga I. Gan","is_ca":true},{"name":"Elisa Laurenti","is_ca":true},{"name":"Laura García‐Prat","is_ca":true},{"name":"Shin‐ichiro Takayanagi","is_ca":true},{"name":"Stanley Ng","is_ca":true},{"name":"Changjiang Xu","is_ca":true},{"name":"Andy G.X. Zeng","is_ca":true},{"name":"Liqing Jin","is_ca":true},{"name":"Jessica McLeod","is_ca":true},{"name":"Elvin Wagenblast","is_ca":true},{"name":"Amanda Mitchell","is_ca":true},{"name":"James A. Kennedy","is_ca":true},{"name":"Qiang Liu","is_ca":true},{"name":"Héléna Boutzen","is_ca":true},{"name":"Melissa Kleinau","is_ca":true},{"name":"Joseph Jargstorf","is_ca":true},{"name":"Gareth D. Holmes","is_ca":true},{"name":"Yang Zhang","is_ca":false},{"name":"Véronique Voisin","is_ca":true},{"name":"Gary D. Bader","is_ca":true},{"name":"Jean Wang","is_ca":true},{"name":"Yusuf A. Hannun","is_ca":false},{"name":"Chiara Luberto","is_ca":false},{"name":"Timm Schroeder","is_ca":false},{"name":"Mark D. Minden","is_ca":true},{"name":"John E. Dick","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0126590363725166,"gpt":0.2071703709343803,"spread":0.1945113345618636,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004022294,0.0002578992,0.0002673643,0.0002563462,0.0002091996,0.0007317198,0.0003407365,0.0007746746,0.003600292],"category_scores_gemma":[0.0004494011,0.0001454699,0.0002738378,0.0001579773,0.0005915423,0.0003473051,0.0004431644,0.002004731,0.001611984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007817876,"about_ca_system_score_gemma":0.0004573005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00052424,"about_ca_topic_score_gemma":0.001702042,"domain_scores_codex":[0.999684,0.00004989358,0.00001580945,0.00004794157,0.0001556112,0.00004673874],"domain_scores_gemma":[0.9997677,0.00008151029,0.00002288149,0.00001334149,0.00007902758,0.00003558259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001658874,0.00020029,0.001523683,0.0008909441,0.00007446481,0.001504346,0.0001717204,0.0004929948,0.476225,0.0119145,0.3768515,0.1284916],"study_design_scores_gemma":[0.0003940806,0.000910554,0.01216674,0.0001878538,0.00007847494,0.002055269,0.0001880642,0.001467982,0.2191557,0.005638157,0.7576978,0.00005929432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.2610298,0.2474965,0.01499927,0.2467502,0.1171496,0.0005017531,0.004667028,0.00238595,0.1050199],"genre_scores_gemma":[0.6040516,0.1565003,0.004312476,0.05235562,0.05105255,0.0002616438,0.001909819,0.0003378984,0.1292181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003600292,"threshold_uncertainty_score":0.01204419,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4281960949","doi":"10.1158/2643-3230.bcd-21-0205","title":"Perspectives on the Risk-Stratified Treatment of Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre","funders":"Cancer Research UK","keywords":"Multiple myeloma; Risk stratification; Stratification (seeds); Medicine; Oncology; Intensive care medicine; Internal medicine; Biology","authors":[{"name":"Faith E. Davies","is_ca":false},{"name":"Charlotte Pawlyn","is_ca":false},{"name":"Saad Z. Usmani","is_ca":false},{"name":"Jesús F. San Miguel","is_ca":false},{"name":"Hermann Einsele","is_ca":false},{"name":"Eileen M. Boyle","is_ca":false},{"name":"Jill Corre","is_ca":false},{"name":"Daniel Auclair","is_ca":false},{"name":"Hearn Jay Cho","is_ca":false},{"name":"Sagar Lonial","is_ca":false},{"name":"Pieter Sonneveld","is_ca":false},{"name":"A. Keith Stewart","is_ca":true},{"name":"P. Leif Bergsagel","is_ca":false},{"name":"Martin Kaiser","is_ca":false},{"name":"Katja Weisel","is_ca":false},{"name":"Jonathan J. Keats","is_ca":false},{"name":"Joseph Mıkhael","is_ca":false},{"name":"Kathryn E. Morgan","is_ca":false},{"name":"Irene M. Ghobrial","is_ca":false},{"name":"Robert Z. Orlowski","is_ca":false},{"name":"Ola Landgren","is_ca":false},{"name":"Francesca Gay","is_ca":false},{"name":"Joseph Caers","is_ca":false},{"name":"Wee Joo Chng","is_ca":false},{"name":"Ajai Chari","is_ca":false},{"name":"Brian A. Walker","is_ca":false},{"name":"Shaji Kumar","is_ca":false},{"name":"Luciano J. Costa","is_ca":false},{"name":"Kenneth C. Anderson","is_ca":false},{"name":"Gareth J. Morgan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03138852994115597,"gpt":0.3023293460820964,"spread":0.2709408161409404,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02050117,0.001193203,0.002128393,0.001394989,0.001217103,0.005204803,0.002700957,0.007054296,0.005662716],"category_scores_gemma":[0.0211072,0.0004511339,0.002132505,0.0007819176,0.006332519,0.005446167,0.003189809,0.01700716,0.001652085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003996103,"about_ca_system_score_gemma":0.006343408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002212759,"about_ca_topic_score_gemma":0.003683248,"domain_scores_codex":[0.9911918,0.005650576,0.0004263166,0.0006083539,0.001697417,0.0004254048],"domain_scores_gemma":[0.9851739,0.009857696,0.0007356092,0.00068204,0.002278455,0.001272276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001221643,0.0006406598,0.002991275,0.002069689,0.0007883355,0.0007253578,0.0007991806,0.005049428,0.001934417,0.4641992,0.172016,0.3475649],"study_design_scores_gemma":[0.0004941709,0.0007887834,0.002844905,0.003006446,0.000416624,0.0009880859,0.0006793279,0.002575523,0.0007200279,0.454918,0.5324063,0.0001619544],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.001586361,0.1839619,0.01310241,0.7816616,0.007397213,0.00004610479,0.0001383594,0.00009054883,0.01201558],"genre_scores_gemma":[0.1021528,0.3809002,0.04427369,0.3728863,0.09061315,0.0004367456,0.0003747973,0.0001671659,0.008195183],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02050117,"threshold_uncertainty_score":0.1084218,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4387114589","doi":"10.1158/2643-3230.bcd-23-0062","title":"Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Baker Hughes (Canada); Institute of Cancer Research","funders":"National Cancer Institute","keywords":"Downregulation and upregulation; Cancer research; Enhancer; IRF4; In vivo; Transcription factor; Biology; Chemistry; Genetics; Gene","authors":[{"name":"Seth J. Welsh","is_ca":false},{"name":"Benjamin G. Barwick","is_ca":false},{"name":"Erin W. Meermeier","is_ca":false},{"name":"Daniel L. Riggs","is_ca":false},{"name":"Chang-Xin Shi","is_ca":false},{"name":"Yuan Xiao Zhu","is_ca":false},{"name":"Meaghen E. Sharik","is_ca":false},{"name":"Megan T. Du","is_ca":false},{"name":"Leslie D. Abrego Rocha","is_ca":false},{"name":"Victoria M. Garbitt","is_ca":false},{"name":"Caleb K. Stein","is_ca":false},{"name":"Joachim L. Petit","is_ca":false},{"name":"Nathalie Meurice","is_ca":false},{"name":"Yuliza Tafoya Alvarado","is_ca":false},{"name":"Rodrigo Fonseca","is_ca":false},{"name":"Kennedi T. Todd","is_ca":false},{"name":"Sochilt Brown","is_ca":false},{"name":"Zachery J. Hammond","is_ca":false},{"name":"Nicklus H. Cuc","is_ca":false},{"name":"Courtney Wittenberg","is_ca":false},{"name":"Camille Herzog","is_ca":false},{"name":"Anna V. Roschke","is_ca":false},{"name":"Yulia N. Demchenko","is_ca":false},{"name":"Wei-dong D. Chen","is_ca":false},{"name":"Peng Li","is_ca":false},{"name":"Wei Liao","is_ca":false},{"name":"Warren J. Leonard","is_ca":false},{"name":"Sagar Lonial","is_ca":false},{"name":"Nizar J. Bahlis","is_ca":true},{"name":"Paola Neri","is_ca":true},{"name":"Lawrence Boise","is_ca":false},{"name":"Marta Chesi","is_ca":false},{"name":"P. Leif Bergsagel","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04422116726956159,"gpt":0.3335979144618268,"spread":0.2893767471922652,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007764953,0.0002330356,0.0004849434,0.0002719056,0.0001990719,0.0006182884,0.0005684718,0.0008479742,0.001013054],"category_scores_gemma":[0.0004517255,0.0001431258,0.0002801957,0.0003532362,0.0005326244,0.0004732943,0.0005594293,0.002536424,0.0004656183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000930566,"about_ca_system_score_gemma":0.0002650223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003498564,"about_ca_topic_score_gemma":0.0009526981,"domain_scores_codex":[0.99964,0.00006883481,0.00002375249,0.00005996549,0.000152291,0.00005515652],"domain_scores_gemma":[0.9997777,0.00009683506,0.00004188084,0.00002034155,0.00003705338,0.00002619385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001458121,0.0004919614,0.001136008,0.001182246,0.0001635742,0.001140379,0.0001981378,0.001407642,0.6734874,0.009330341,0.03909207,0.2709121],"study_design_scores_gemma":[0.000902791,0.005283316,0.00553785,0.000156334,0.0003214451,0.003553118,0.0001773407,0.002497895,0.587488,0.004011197,0.390002,0.00006860671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5884623,0.2998865,0.01739871,0.05626279,0.006434795,0.0004355165,0.001032583,0.001312612,0.02877404],"genre_scores_gemma":[0.8748295,0.08880799,0.004534722,0.01451256,0.00283881,0.0003154977,0.000584118,0.0002357309,0.01334105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013054,"threshold_uncertainty_score":0.006751716,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4220858033","doi":"10.1158/2643-3230.bcd-21-0092","title":"Reconstructing Complex Cancer Evolutionary Histories from Multiple Bulk DNA Samples Using Pairtree","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; Vector Institute; Artificial Intelligence in Medicine (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health","keywords":"clone (Java method); Cancer; Genome; Phylogenetics; Disease; Complex disease","authors":[],"retraction":null,"screen_n_in":null,"score":{"opus":0.03286776492797187,"gpt":0.2526574427517208,"spread":0.2197896778237489,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006349409,0.0008126282,0.0008502411,0.002013029,0.001420273,0.002419346,0.002666953,0.003598089,0.003721712],"category_scores_gemma":[0.03444614,0.001040591,0.002088335,0.002310548,0.002988135,0.005723062,0.002359381,0.009523124,0.002116319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001948845,"about_ca_system_score_gemma":0.00141745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005264611,"about_ca_topic_score_gemma":0.01438313,"domain_scores_codex":[0.998417,0.000713572,0.00008413479,0.0003749902,0.0003536,0.00005668283],"domain_scores_gemma":[0.9873106,0.009096007,0.0006347061,0.001183349,0.001343647,0.0004316007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000507254,0.00006024155,0.01915708,0.001501259,0.001096507,0.001201391,0.003134538,0.06135312,0.01221071,0.1488337,0.3606539,0.3902902],"study_design_scores_gemma":[0.0001029305,0.00009453222,0.007369068,0.0006658264,0.0002212426,0.002016048,0.0008333514,0.1344579,0.009359425,0.4965127,0.3480343,0.0003327293],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.02378092,0.01198341,0.860424,0.08138096,0.008032337,0.00008824821,0.004267393,0.004450908,0.005591852],"genre_scores_gemma":[0.1860419,0.0162568,0.7465037,0.02602139,0.006373642,0.0003638855,0.005076926,0.004418258,0.008943539],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006349409,"threshold_uncertainty_score":0.03357929,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3009636168","doi":"10.1158/0008-5472.bcd-19-0039","title":"Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on <i>MIR300</i> Antiproliferative and PP2A-Activating Functions","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; National Institutes of Health; Cancer Research Society; National Natural Science Foundation of China; American Cyronics Society; U.S. Department of Defense","keywords":"Progenitor cell; Cancer research; Protein phosphatase 2; Biology; Stem cell; Immune system; Immunology; Leukemia; Apoptosis; Cell biology; Phosphatase; Phosphorylation","authors":[{"name":"Giovannino Silvestri","is_ca":false},{"name":"Rossana Trotta","is_ca":false},{"name":"Lorenzo Stramucci","is_ca":false},{"name":"Justin J. Ellis","is_ca":false},{"name":"Jason G. Harb","is_ca":false},{"name":"Paolo Neviani","is_ca":false},{"name":"Shuzhen Wang","is_ca":false},{"name":"Ann‐Kathrin Eisfeld","is_ca":false},{"name":"Christopher J. Walker","is_ca":false},{"name":"Bin Zhang","is_ca":false},{"name":"Klára Šrůtová","is_ca":false},{"name":"Carlo Gambacorti‐Passerini","is_ca":false},{"name":"Gabriel Pineda","is_ca":false},{"name":"Catriona Jamieson","is_ca":false},{"name":"Fabio Stagno","is_ca":false},{"name":"Paolo Vigneri","is_ca":false},{"name":"Georgios Nteliopoulos","is_ca":false},{"name":"Philippa C. May","is_ca":false},{"name":"Alistair Reid","is_ca":false},{"name":"Ramiro Garzon","is_ca":false},{"name":"Denis‐Claude Roy","is_ca":true},{"name":"Moutuaata M. Moutuou","is_ca":true},{"name":"Martin Guimond","is_ca":true},{"name":"Peter Hokland","is_ca":false},{"name":"Michael W. Deininger","is_ca":false},{"name":"Garrett Fitzgerald","is_ca":false},{"name":"Christopher Harman","is_ca":false},{"name":"Francesco Dazzi","is_ca":false},{"name":"Dragana Milojković","is_ca":false},{"name":"Jane F. Apperley","is_ca":false},{"name":"Guido Marcucci","is_ca":false},{"name":"Jianfei Qi","is_ca":false},{"name":"Kateřina Machová Poláková","is_ca":false},{"name":"Ying Zou","is_ca":false},{"name":"Xiaoxuan Fan","is_ca":false},{"name":"Maria R. Baer","is_ca":false},{"name":"Bruno Calabretta","is_ca":false},{"name":"Danilo Perrotti","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01585045797614332,"gpt":0.2071715928590338,"spread":0.1913211348828905,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009261814,0.0001555447,0.0002001554,0.0002276143,0.0001431669,0.0002455553,0.00008158457,0.0001613394,0.001584756],"category_scores_gemma":[0.0001813252,0.00008217274,0.0001274558,0.0001486215,0.000149769,0.0001222594,0.0001013837,0.0003107491,0.0002681436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002030615,"about_ca_system_score_gemma":0.0001072374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001957663,"about_ca_topic_score_gemma":0.0002159013,"domain_scores_codex":[0.9999244,0.000009248823,0.000009130494,0.00001992143,0.00002307244,0.00001409027],"domain_scores_gemma":[0.9999137,0.00001182352,0.00003718438,0.000005810251,0.000008076457,0.00002338632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003117805,0.0001936358,0.1483247,0.00008815686,0.00005370297,0.001030527,0.0000989846,0.0001778284,0.8147753,0.0003023523,0.0007256265,0.03111131],"study_design_scores_gemma":[0.0001469564,0.001781617,0.719964,0.00001936404,0.0001291177,0.01167728,0.0001337046,0.001733185,0.2572059,0.0004314262,0.006757644,0.00001995231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976491,0.0006227272,0.0004490383,0.0000682059,0.000006848444,0.00001535762,0.0002173831,0.00004065325,0.0009305024],"genre_scores_gemma":[0.9990344,0.0001177419,0.000247724,0.00003481547,0.00000755266,0.0000101861,0.0002189825,0.000004563984,0.0003240243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001584756,"threshold_uncertainty_score":0.005301595,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4388451947","doi":"10.1158/2643-3230.bcd-23-0061","title":"ETV4-Dependent Transcriptional Plasticity Maintains <i>MYC</i> Expression and Results in IMiD Resistance in Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Paula and Rodger Riney Foundation; American Society of Hematology; Multiple Myeloma Research Foundation","keywords":"Transcription factor; Enhancer; Chromatin immunoprecipitation; Chromatin; Biology; Cancer research; Genetics; Promoter; Gene expression; Gene","authors":[{"name":"Paola Neri","is_ca":true},{"name":"Benjamin G. Barwick","is_ca":false},{"name":"David Jung","is_ca":true},{"name":"Jonathan C. Patton","is_ca":false},{"name":"Ranjan Maity","is_ca":true},{"name":"Inès Tagoug","is_ca":true},{"name":"Caleb K. Stein","is_ca":false},{"name":"Rémi Tilmont","is_ca":true},{"name":"Noémie Leblay","is_ca":true},{"name":"Sungwoo Ahn","is_ca":true},{"name":"Holly Lee","is_ca":true},{"name":"Seth J. Welsh","is_ca":false},{"name":"Daniel L. Riggs","is_ca":false},{"name":"Nicholas Stong","is_ca":false},{"name":"Erin Flynt","is_ca":false},{"name":"Anjan Thakurta","is_ca":false},{"name":"Jonathan J. Keats","is_ca":false},{"name":"Sagar Lonial","is_ca":false},{"name":"P. Leif Bergsagel","is_ca":false},{"name":"Lawrence Boise","is_ca":false},{"name":"Nizar J. Bahlis","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02987792591273875,"gpt":0.2922991076502167,"spread":0.2624211817374779,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031327,0.0002344962,0.0001980518,0.0001682194,0.0001567468,0.0002916071,0.0002434679,0.0002568227,0.001690507],"category_scores_gemma":[0.0001080366,0.0001194504,0.0003234186,0.0001444019,0.0002120264,0.0001666769,0.0002226413,0.0006890443,0.0004310037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005298536,"about_ca_system_score_gemma":0.0001406048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005415528,"about_ca_topic_score_gemma":0.0006707896,"domain_scores_codex":[0.999867,0.00001586561,0.00001143047,0.00003806901,0.00003410705,0.00003349888],"domain_scores_gemma":[0.9999368,0.000009572609,0.00002341268,0.0000113732,0.000007055183,0.00001185155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005489777,0.00001252011,0.0002748016,0.0000169325,0.000004170867,0.00002194243,0.000004796538,0.0001062759,0.9980485,0.0000587351,0.0000450473,0.001351308],"study_design_scores_gemma":[0.000009339163,0.00007177755,0.004498675,0.000002981366,0.00001053594,0.0002336595,0.00001371538,0.001000606,0.9913584,0.00005425019,0.002742857,0.000003236884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905143,0.00147742,0.005207317,0.0001443186,0.00004067924,0.00002290978,0.0007720108,0.0002646277,0.001556322],"genre_scores_gemma":[0.9939421,0.00037089,0.001530801,0.00006104816,0.000006016418,0.00001890228,0.0008865457,0.00004623388,0.003137367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001690507,"threshold_uncertainty_score":0.005655289,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4404970989","doi":"10.1158/2643-3230.bcd-23-0258","title":"CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells","year":2024,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Hyundai Hope On Wheels; Saban Research Institute; CureSearch for Children's Cancer; National Cancer Institute; St. Baldrick's Foundation; University of Southern California","keywords":"Interleukin-3 receptor; Cancer research; Haematopoiesis; CD33; Immunotherapy; Progenitor cell; Cytokine release syndrome; Leukemia; T cell; Stem cell; Immunology; Medicine; Biology; CD34; Myeloid; Chimeric antigen receptor; Cell biology; Immune system","authors":[{"name":"Samy Jambon","is_ca":false},{"name":"Jianping Sun","is_ca":false},{"name":"Shawn Barman","is_ca":false},{"name":"Sakunthala Muthugounder","is_ca":false},{"name":"Xue Rachel Bito","is_ca":false},{"name":"Armita Shadfar","is_ca":false},{"name":"Alexandra E. Kovach","is_ca":false},{"name":"Brent L. Wood","is_ca":false},{"name":"Varsha Thoppey Manoharan","is_ca":true},{"name":"A. Sorana Morrissy","is_ca":true},{"name":"Deepa Bhojwani","is_ca":false},{"name":"Alan S. Wayne","is_ca":false},{"name":"Michael A. Pulsipher","is_ca":false},{"name":"Yong‐Mi Kim","is_ca":false},{"name":"Shahab Asgharzadeh","is_ca":false},{"name":"Chintan Parekh","is_ca":false},{"name":"Babak Moghimi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02216345704150889,"gpt":0.2911391256570107,"spread":0.2689756686155018,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009619667,0.0003026997,0.0001707187,0.0001150608,0.00009584552,0.0003350437,0.0001978491,0.0002029231,0.001307044],"category_scores_gemma":[0.0001031642,0.00006891964,0.0001063679,0.00008562359,0.0001635427,0.0001858548,0.0001676505,0.0003398003,0.0001834245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002591807,"about_ca_system_score_gemma":0.0001705646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000277021,"about_ca_topic_score_gemma":0.0002966503,"domain_scores_codex":[0.9998907,0.00001291988,0.00000744914,0.00002363046,0.00002679864,0.00003856083],"domain_scores_gemma":[0.9999294,0.000008882124,0.00002421269,0.000009415739,0.00001379927,0.00001427338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009248979,0.00002713501,0.0002878468,0.00001731162,0.000002532675,0.00002742171,0.000009271105,0.0002916688,0.9970631,0.000258956,0.00006062887,0.001861637],"study_design_scores_gemma":[0.00001351446,0.0002492393,0.0008624982,0.00000173893,0.00001018132,0.0001186617,0.000008273597,0.003355609,0.9943427,0.00005070392,0.0009846977,0.000002200823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904496,0.0001461619,0.008046769,0.00005724677,0.00001143975,0.00002823082,0.00006325554,0.0001476886,0.001049549],"genre_scores_gemma":[0.9966986,0.00005239369,0.002488112,0.00003170433,0.000003813651,0.00001259987,0.00005978944,0.00001837514,0.0006347541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307044,"threshold_uncertainty_score":0.004372478,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4319827008","doi":"10.1158/2643-3230.bcd-22-0086","title":"<i>In Vivo</i> Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; McMaster University; University of Toronto; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Stem cell; RNA-binding protein; In vivo; RNA; Cell biology; Computational biology; Biology; Genetics; Gene","authors":[{"name":"Ana Vujovic","is_ca":true},{"name":"Laura de Rooij","is_ca":true},{"name":"Ava Keyvani Chahi","is_ca":true},{"name":"He Tian Chen","is_ca":true},{"name":"Brian A. Yee","is_ca":false},{"name":"Sampath K. Loganathan","is_ca":true},{"name":"Lina Liu","is_ca":true},{"name":"Derek C.H. Chan","is_ca":true},{"name":"Amanda Tajik","is_ca":true},{"name":"Emily Tsao","is_ca":true},{"name":"Steven Moreira","is_ca":true},{"name":"Pratik Joshi","is_ca":true},{"name":"Joshua Xu","is_ca":true},{"name":"Nicholas Wong","is_ca":true},{"name":"Zaldy Balde","is_ca":true},{"name":"Soheil Jahangiri","is_ca":true},{"name":"Sasan Zandi","is_ca":true},{"name":"Stefan Aigner","is_ca":false},{"name":"John E. Dick","is_ca":true},{"name":"Mark D. Minden","is_ca":true},{"name":"Daniel Schramek","is_ca":true},{"name":"G Yeo","is_ca":false},{"name":"Kristin J. Hope","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02521687011719345,"gpt":0.2930405608347814,"spread":0.2678236907175879,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000206517,0.000465457,0.0003151126,0.0003215984,0.0001842683,0.0005296064,0.0002755963,0.0003549635,0.002650894],"category_scores_gemma":[0.0001606115,0.0001573018,0.0002547551,0.0001995426,0.0003026411,0.0001825145,0.0003277333,0.000681753,0.00101623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004356007,"about_ca_system_score_gemma":0.0002510168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005727722,"about_ca_topic_score_gemma":0.001257989,"domain_scores_codex":[0.9997503,0.00002632683,0.00002126408,0.00006956322,0.00009439373,0.00003823838],"domain_scores_gemma":[0.9998449,0.00003135015,0.00006144721,0.00002159212,0.00001751738,0.00002312189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001785978,0.000009710685,0.0002328094,0.000017304,0.000003121871,0.00003030605,0.00000568326,0.0001244565,0.9979178,0.0001094104,0.00009739933,0.001434132],"study_design_scores_gemma":[0.000002288059,0.00005877299,0.001060094,0.000002498623,0.000009565657,0.000190769,0.00001008964,0.0007434617,0.9952657,0.00004758198,0.002606125,0.000002967564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9338831,0.001530492,0.04469776,0.0005464453,0.00006602037,0.0001450932,0.005873533,0.002618594,0.01063887],"genre_scores_gemma":[0.9725243,0.0009118001,0.01600535,0.0002902972,0.0000105179,0.00006699012,0.004123863,0.0003374489,0.005729333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002650894,"threshold_uncertainty_score":0.008868098,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4220999992","doi":"10.1158/2643-3230.bcd-22-0013","title":"Patients Recently Treated for B-lymphoid Malignancies Show Increased Risk of Severe COVID-19","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"COVID-19 and healthcare impacts","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Hope Foundation; American Cancer Society","keywords":"Malignancy; Risk factor; Population; Cancer; Disease; Risk assessment","authors":[],"retraction":null,"screen_n_in":null,"score":{"opus":0.03486765714881442,"gpt":0.3310159339861123,"spread":0.2961482768372979,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156237,0.0000851873,0.0001749394,0.000297174,0.0003051321,0.0003961331,0.0001562298,0.000268217,0.003383478],"category_scores_gemma":[0.001745652,0.00005593883,0.0002631833,0.000565123,0.0001340829,0.0002123273,0.0004983009,0.0006030038,0.0001823004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002283229,"about_ca_system_score_gemma":0.0003519492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630147,"about_ca_topic_score_gemma":0.003464008,"domain_scores_codex":[0.9997217,0.00007479047,0.00002481427,0.00005044742,0.00005917158,0.00006901582],"domain_scores_gemma":[0.9986061,0.0001945537,0.0007945769,0.000045927,0.00008575017,0.0002731249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000158507,0.00003213181,0.9903291,0.00001551678,0.00004363995,0.0001604825,0.00006177329,0.00005758897,0.0006988075,0.00008748153,0.0005789374,0.007775984],"study_design_scores_gemma":[0.000004437628,0.0001179147,0.9975173,0.00001075204,0.00002192507,0.0007148418,0.0001628626,0.0001203585,0.000205405,0.00009098379,0.001029012,0.000004174933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956191,0.0009163023,0.0002801672,0.0005621024,0.00002171166,0.00001001032,0.0005103255,0.00001022783,0.002070013],"genre_scores_gemma":[0.9985495,0.0002994475,0.0001666866,0.0001529007,0.00002778022,0.000004319523,0.000422418,0.000003051847,0.000373945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003383478,"threshold_uncertainty_score":0.01131892,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3086857979","doi":"10.1158/2643-3230.bcd-20-0076","title":"PRPS-ST: A Protocol-Agnostic Self-training Method for Gene Expression–Based Classification of Blood Cancers","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; Spinal Cord Injury BC; University of British Columbia","funders":"National Cancer Institute; Terry Fox Research Institute","keywords":"Computer science; Gene expression; Gene; Porting; Training set; Artificial intelligence; Machine learning; Computational biology; Data mining; Biology; Genetics","authors":[{"name":"Aixiang Jiang","is_ca":true},{"name":"Laura K. Hilton","is_ca":true},{"name":"Jeffrey Tang","is_ca":true},{"name":"Christopher Rushton","is_ca":true},{"name":"Bruno M. Grande","is_ca":true},{"name":"David W. Scott","is_ca":true},{"name":"Ryan D. Morin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03953959371689576,"gpt":0.3265509782736628,"spread":0.2870113845567671,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003958453,0.0006725762,0.0005580606,0.001256951,0.0003993229,0.0008801466,0.001216922,0.0006737419,0.004872164],"category_scores_gemma":[0.008052075,0.0004707292,0.0007258194,0.0006981565,0.0005670175,0.0006539153,0.000859418,0.001387654,0.002684858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004021738,"about_ca_system_score_gemma":0.0009707605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005098712,"about_ca_topic_score_gemma":0.0008559729,"domain_scores_codex":[0.9979466,0.0005421956,0.0001976038,0.00051152,0.0007162506,0.00008581456],"domain_scores_gemma":[0.9970804,0.001252831,0.0003495729,0.0005566831,0.0006716157,0.00008891358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001136254,0.0004737155,0.01308001,0.0003893798,0.0002215139,0.0002731539,0.000204505,0.02908398,0.270587,0.003624568,0.01962475,0.6613012],"study_design_scores_gemma":[0.0001033294,0.0005049117,0.007490527,0.00002773431,0.00006210457,0.0004083896,0.0000392188,0.699491,0.2768998,0.003433789,0.01146551,0.00007382602],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.05507426,0.0001801676,0.9225038,0.0002287036,0.0001755618,0.0003714181,0.0008382474,0.01917295,0.001455019],"genre_scores_gemma":[0.3009174,0.0001711272,0.6882797,0.0003101098,0.0001496803,0.001057656,0.003219827,0.001564182,0.004330179],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004872164,"threshold_uncertainty_score":0.02093452,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4252017764","doi":"10.1158/2643-3249.bcd-19-0041","title":"Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institutes of Health; National Cancer Institute; KWF Kankerbestrijding; China Scholarship Council","keywords":"Somatic evolution in cancer; Biology; Somatic hypermutation; Genetics; Mutation; Leukemia; Deep sequencing; Cancer; Gene; Cancer research; Genome; B cell","authors":[{"name":"Esmé Waanders","is_ca":false},{"name":"Zhaohui Gu","is_ca":false},{"name":"Stephanie M. Dobson","is_ca":true},{"name":"Željko Antić","is_ca":false},{"name":"Jeremy Chase Crawford","is_ca":false},{"name":"Xiaotu Ma","is_ca":false},{"name":"Michael N. Edmonson","is_ca":false},{"name":"Debbie Payne-Turner","is_ca":false},{"name":"Maartje van de Vorst","is_ca":false},{"name":"Marjolijn C.J. Jongmans","is_ca":false},{"name":"Irina McGuire","is_ca":false},{"name":"Xin Zhou","is_ca":false},{"name":"Jian Wang","is_ca":false},{"name":"Lei Shi","is_ca":false},{"name":"Stanley Pounds","is_ca":false},{"name":"Deqing Pei","is_ca":false},{"name":"Cheng Cheng","is_ca":false},{"name":"Guangchun Song","is_ca":false},{"name":"Yiping Fan","is_ca":false},{"name":"Ying Shao","is_ca":false},{"name":"Michael Rusch","is_ca":false},{"name":"Kelly McCastlain","is_ca":false},{"name":"Jiangyan Yu","is_ca":false},{"name":"Ruben van Boxtel","is_ca":false},{"name":"Francis Blokzijl","is_ca":false},{"name":"Ilaria Iacobucci","is_ca":false},{"name":"Kathryn G. Roberts","is_ca":false},{"name":"Ji Wen","is_ca":false},{"name":"Gang Wu","is_ca":false},{"name":"Jing Ma","is_ca":false},{"name":"John Easton","is_ca":false},{"name":"Geoffrey Neale","is_ca":false},{"name":"Scott R. Olsen","is_ca":false},{"name":"Kim E. Nichols","is_ca":false},{"name":"Ching‐Hon Pui","is_ca":false},{"name":"Jinghui Zhang","is_ca":false},{"name":"William E. Evans","is_ca":false},{"name":"Mary V. Relling","is_ca":false},{"name":"Jun Yang","is_ca":false},{"name":"Paul G. Thomas","is_ca":false},{"name":"John E. Dick","is_ca":true},{"name":"Roland P. Kuiper","is_ca":false},{"name":"Charles G. Mullighan","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005172263114851585,"gpt":0.2139116121115461,"spread":0.2087393489966945,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450559,0.00007297915,0.00009987591,0.0006284269,0.00009823504,0.0002468184,0.0001196871,0.0001314559,0.0004532043],"category_scores_gemma":[0.0002850346,0.00008192331,0.00006700733,0.0003160573,0.0001705484,0.0001279275,0.0001669142,0.0001141075,0.00009633014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002268644,"about_ca_system_score_gemma":0.00005906671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000607215,"about_ca_topic_score_gemma":0.001053241,"domain_scores_codex":[0.9998974,0.00001701141,0.000006543982,0.0000277627,0.00002852483,0.00002275838],"domain_scores_gemma":[0.9998782,0.0000285233,0.00004520569,0.00001383759,0.0000190897,0.00001518429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006284809,0.00004356327,0.2404129,0.00006194849,0.00003548529,0.0005542866,0.0003273357,0.001263194,0.7282269,0.0003218125,0.0001353517,0.02798867],"study_design_scores_gemma":[0.0000153665,0.0003163058,0.9084254,0.000008825722,0.00003775427,0.003762576,0.000300827,0.005856741,0.07923768,0.0003486231,0.001676614,0.00001331174],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992035,0.000212243,0.0002535236,0.000006134419,3.129471e-7,0.000003998814,0.00009179065,0.00001191273,0.0002165111],"genre_scores_gemma":[0.9991519,0.0001228853,0.0003819822,0.000008506852,9.799245e-7,0.000005373992,0.0002003027,0.000004399144,0.0001236814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006284269,"threshold_uncertainty_score":0.001646042,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3206893004","doi":"10.1158/2643-3230.bcd-20-0216","title":"Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target","year":2021,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Vector Institute; Ontario Institute for Cancer Research; Amgen (Canada); Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Novo Nordisk Fonden; Canadian Institutes of Health Research; KWF Kankerbestrijding; Novo Nordisk; Canadian Cancer Society; Hospital for Sick Children; Government of Ontario","keywords":"Profiling (computer programming); Translation (biology); Messenger RNA; Central nervous system; Neuroscience; Computational biology; Biology; Computer science; Gene; Genetics","authors":[{"name":"Robert J. Vanner","is_ca":true},{"name":"Stephanie M. Dobson","is_ca":true},{"name":"Olga I. Gan","is_ca":true},{"name":"Jessica McLeod","is_ca":true},{"name":"Erwin M. Schoof","is_ca":false},{"name":"Ildiko Grandal","is_ca":true},{"name":"Jeff Wintersinger","is_ca":true},{"name":"Laura García‐Prat","is_ca":true},{"name":"Mohsen Hosseini","is_ca":true},{"name":"Stephanie Z. Xie","is_ca":true},{"name":"Liqing Jin","is_ca":true},{"name":"Nathan Mbong","is_ca":true},{"name":"Véronique Voisin","is_ca":true},{"name":"Michelle Chan‐Seng‐Yue","is_ca":true},{"name":"Theodore A. Kennedy","is_ca":true},{"name":"Esmé Waanders","is_ca":false},{"name":"Quaid Morris","is_ca":true},{"name":"Bo Porse","is_ca":false},{"name":"Steven M. Chan","is_ca":true},{"name":"Cynthia J. Guidos","is_ca":true},{"name":"Jayne S. Danska","is_ca":true},{"name":"Mark D. Minden","is_ca":true},{"name":"Charles G. Mullighan","is_ca":false},{"name":"John E. Dick","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01996526487059861,"gpt":0.2902066750362585,"spread":0.2702414101656599,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009903225,0.0002065061,0.0001525094,0.0003517061,0.0001382217,0.0003597972,0.00008360982,0.0001613657,0.00102903],"category_scores_gemma":[0.0001046165,0.00007178123,0.0001211814,0.00030782,0.0001109052,0.0001289311,0.0001559319,0.000246112,0.0003136476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299524,"about_ca_system_score_gemma":0.0001824715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003949704,"about_ca_topic_score_gemma":0.0007677879,"domain_scores_codex":[0.9999135,0.000009887008,0.000005444811,0.00002168134,0.0000327034,0.00001676971],"domain_scores_gemma":[0.9999398,0.000008649964,0.00002249693,0.000004314389,0.00001432741,0.00001042387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006182431,0.000008223391,0.000841076,0.00001625482,0.000003042803,0.00001835455,0.00000502964,0.00003170982,0.9972903,0.000021202,0.00004812343,0.001654913],"study_design_scores_gemma":[0.000009403456,0.0003118728,0.04645356,0.000007167212,0.0000324201,0.0003927817,0.00005963095,0.001327393,0.9483454,0.00008897908,0.002966334,0.000005096059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889024,0.001938129,0.004915931,0.0001453785,0.00002312987,0.00004547121,0.002401339,0.0001122417,0.001515923],"genre_scores_gemma":[0.9865681,0.001766309,0.006229485,0.0001177716,0.00001398932,0.00006174426,0.002386523,0.0000336614,0.002822489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102903,"threshold_uncertainty_score":0.003442526,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4413976388","doi":"10.1158/2643-3230.bcd-25-0005","title":"Timing Genomic Antigen Loss in Multiple Myeloma Treated with T Cell–Redirecting Immunotherapies","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Occupational Cancer Research Centre; University of Calgary","funders":"National Cancer Institute; National Institutes of Health","keywords":"Chimeric antigen receptor; CAR T-cell therapy; Multiple myeloma; Antigen; Immunology; Immunotherapy; Digital polymerase chain reaction; Medicine; Biology; Oncology; Cancer research; Genetics; Immune system; Polymerase chain reaction; Gene","authors":[{"name":"Marios Papadimitriou","is_ca":false},{"name":"Sungwoo Ahn","is_ca":true},{"name":"Benjamin Diamond","is_ca":false},{"name":"Holly Lee","is_ca":true},{"name":"John B. McIntyre","is_ca":true},{"name":"Marietta Truger","is_ca":false},{"name":"Michael Durante","is_ca":false},{"name":"Bachisio Ziccheddu","is_ca":false},{"name":"Katalin Osz","is_ca":true},{"name":"Ola Landgren","is_ca":false},{"name":"Leo Rasche","is_ca":false},{"name":"Nizar J. Bahlis","is_ca":true},{"name":"Paola Neri","is_ca":true},{"name":"Francesco Maura","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01903899341181398,"gpt":0.2854513872654947,"spread":0.2664123938536807,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199568,0.0001616124,0.0004824715,0.0003073604,0.0002289882,0.000799026,0.0003975069,0.001299853,0.0005947324],"category_scores_gemma":[0.0034795,0.000158829,0.0003157953,0.0003896469,0.0005262658,0.0005446307,0.0003636308,0.002190557,0.000253612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001426723,"about_ca_system_score_gemma":0.0005493524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345174,"about_ca_topic_score_gemma":0.00280989,"domain_scores_codex":[0.9995087,0.0001449976,0.000038599,0.0001073304,0.0001514675,0.0000488629],"domain_scores_gemma":[0.9987717,0.0006803331,0.0002441008,0.00006339624,0.0001665242,0.00007389637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006870072,0.0003739898,0.05468027,0.001493915,0.0004371394,0.00316146,0.0007005552,0.001920308,0.101412,0.003734518,0.09323996,0.7319759],"study_design_scores_gemma":[0.001924672,0.01208197,0.3441623,0.002310805,0.001931407,0.01494487,0.001199474,0.01258716,0.1697023,0.01961222,0.4192071,0.0003357476],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5429977,0.253256,0.01360913,0.1636719,0.009194575,0.0002116555,0.001327962,0.0008864141,0.01484465],"genre_scores_gemma":[0.9110348,0.0426066,0.002677939,0.03507312,0.004790964,0.0001128336,0.0003062719,0.0001070575,0.003290461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426723,"threshold_uncertainty_score":0.01035166,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4410595562","doi":"10.1158/2643-3230.bcd-25-0099","title":"B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with <i>MYC</i> and <i>BCL2</i> Rearrangements","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Optech (Canada)","funders":"H2020 Marie Skłodowska-Curie Actions; Fondazione Beretta; Fondazione Cariplo; American Society of Hematology; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"Gene silencing; B cell; Cancer research; Biology; Cell; Genetics; Gene; Antibody","authors":[{"name":"Gabriele Varano","is_ca":false},{"name":"Silvia Lonardi","is_ca":false},{"name":"Paola Sindaco","is_ca":false},{"name":"Ilaria Pietrini","is_ca":false},{"name":"Gaia Morello","is_ca":false},{"name":"Piera Balzarini","is_ca":false},{"name":"Filippo Vit","is_ca":false},{"name":"Hadas Neuman","is_ca":false},{"name":"Giorgio Bertolazzi","is_ca":false},{"name":"Silvia Brambillasca","is_ca":false},{"name":"Nicara C. Parr","is_ca":false},{"name":"Marco Chiarini","is_ca":false},{"name":"Silvia Bellesi","is_ca":false},{"name":"Elena Maiolo","is_ca":false},{"name":"Sabrina Giampaolo","is_ca":false},{"name":"Federica Mainoldi","is_ca":false},{"name":"Viveka Selvarasa","is_ca":false},{"name":"Hiroshi Arima","is_ca":false},{"name":"Vilma Pellegrini","is_ca":false},{"name":"Chiara Pagani","is_ca":false},{"name":"Mattia Bugatti","is_ca":false},{"name":"Cecilia Ranise","is_ca":false},{"name":"Tommaso M. Taddei","is_ca":false},{"name":"Takashi Sonoki","is_ca":false},{"name":"Hajdica Thanasi","is_ca":false},{"name":"Elena Morlacchi","is_ca":false},{"name":"Daniel Segura-Garzón","is_ca":false},{"name":"Emma Albertini","is_ca":false},{"name":"Rosa Daffini","is_ca":false},{"name":"Anojan Sivacegaram","is_ca":false},{"name":"Henry Yang","is_ca":false},{"name":"Ying Li","is_ca":false},{"name":"Valeria Cancila","is_ca":false},{"name":"Giada Cicio","is_ca":false},{"name":"Michela Robusto","is_ca":false},{"name":"Brian Leuzzi","is_ca":false},{"name":"Adrian Andronache","is_ca":false},{"name":"Paolo Trifiró","is_ca":false},{"name":"Mirko Riboni","is_ca":true},{"name":"Simone P. Minardi","is_ca":true},{"name":"Raoul J.P. Bonnal","is_ca":false},{"name":"Cristina López","is_ca":false},{"name":"Euplio Visco","is_ca":false},{"name":"Pasquale Capaccio","is_ca":false},{"name":"Sara Torretta","is_ca":false},{"name":"Lorenzo Pignataro","is_ca":false},{"name":"Camillo Almici","is_ca":false},{"name":"Mario Varasi","is_ca":false},{"name":"Luigi Maria Larocca","is_ca":false},{"name":"Reiner Siebert","is_ca":false},{"name":"Brunangelo Falini","is_ca":false},{"name":"Andrés J.M. Ferreri","is_ca":false},{"name":"Alessandra Tucci","is_ca":false},{"name":"Daniele Lorenzini","is_ca":false},{"name":"Antonello D. Cabras","is_ca":false},{"name":"Giancarlo Pruneri","is_ca":false},{"name":"Arianna Di Napoli","is_ca":false},{"name":"Marco Ungari","is_ca":false},{"name":"Marco Pizzi","is_ca":false},{"name":"Stefan Hohaus","is_ca":false},{"name":"Ciro Mercurio","is_ca":false},{"name":"Joo Y. Song","is_ca":false},{"name":"Wing C. Chan","is_ca":false},{"name":"Luisa Lorenzi","is_ca":false},{"name":"Riccardo Bomben","is_ca":false},{"name":"Maurilio Ponzoni","is_ca":false},{"name":"Ramit Mehr","is_ca":false},{"name":"Claudio Tripodo","is_ca":false},{"name":"Fabio Facchetti","is_ca":false},{"name":"Stefano Casola","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01386809793508148,"gpt":0.2705367684569447,"spread":0.2566686705218633,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006219,0.0001348864,0.0001060674,0.0001568443,0.0000717479,0.0003473822,0.000130532,0.0001493407,0.001208395],"category_scores_gemma":[0.00006639905,0.0001034379,0.0001227042,0.0001119424,0.0001042517,0.0001592292,0.0001469097,0.0004435473,0.0004652486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349534,"about_ca_system_score_gemma":0.00008997306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005937101,"about_ca_topic_score_gemma":0.0008773968,"domain_scores_codex":[0.999897,0.000009546101,0.000007413391,0.00002230503,0.0000262724,0.00003757793],"domain_scores_gemma":[0.9999284,0.00001168528,0.00002042889,0.00001089541,0.000006895347,0.00002171836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006607679,0.00001787093,0.0005493743,0.000005991273,0.000002310675,0.0000246769,0.000007123259,0.00003617299,0.998343,0.00007860715,0.00002474777,0.0008441258],"study_design_scores_gemma":[0.00001221947,0.0002172541,0.01920114,0.000002825198,0.00001762372,0.0004244176,0.0000413714,0.001348685,0.9771254,0.00005113224,0.001554414,0.000003533926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971554,0.0003738118,0.0008452056,0.00002264741,0.000004456491,0.000008739059,0.0002188306,0.00006547866,0.001305383],"genre_scores_gemma":[0.9978988,0.000176243,0.0003356815,0.00001948442,0.000002810559,0.000008629263,0.0003857319,0.00002190473,0.001150684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001208395,"threshold_uncertainty_score":0.004042506,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4407345273","doi":"10.1158/2643-3230.bcd-24-0140","title":"SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Toronto General Hospital; University of Calgary; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Suppressor of cytokine signaling 1; Myeloid leukemia; Cancer research; CD8; Leukemia; Immunotherapy; Cytotoxic T cell; Immunology; Medicine; Biology; Cancer; Immune system; Internal medicine; In vitro; Suppressor","authors":[{"name":"Enoch Tin","is_ca":true},{"name":"Sergio Rutella","is_ca":false},{"name":"Ismat Khatri","is_ca":true},{"name":"Yoosu Na","is_ca":true},{"name":"Yongran Yan","is_ca":true},{"name":"Neil MacLean","is_ca":true},{"name":"Jayakumar Vadakekolathu","is_ca":false},{"name":"Mark D. Minden","is_ca":true},{"name":"Aaron D. Schimmer","is_ca":true},{"name":"Jong Bok Lee","is_ca":true},{"name":"Zhang Li","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01176906278345112,"gpt":0.2694262694282391,"spread":0.257657206644788,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002540711,0.0002940118,0.0001960275,0.0001781558,0.0001139456,0.0002665699,0.0001597562,0.0003684387,0.002775176],"category_scores_gemma":[0.000222647,0.00005935422,0.0002044738,0.0000850022,0.0004149499,0.0001526923,0.0002578589,0.001212659,0.000673895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004070076,"about_ca_system_score_gemma":0.0003095841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003210712,"about_ca_topic_score_gemma":0.0005680093,"domain_scores_codex":[0.9998959,0.00002270357,0.000006073422,0.00001536513,0.00003063928,0.00002926309],"domain_scores_gemma":[0.9999086,0.00002619205,0.00001471743,0.000008656791,0.00002272166,0.00001910263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002620022,0.0002687782,0.001048942,0.0009822395,0.0001198052,0.0004614862,0.00005871048,0.000710284,0.6972549,0.008719763,0.1054214,0.1823338],"study_design_scores_gemma":[0.0009987311,0.003236673,0.01082049,0.0002318891,0.0001624319,0.001212895,0.00009821081,0.002005776,0.5147855,0.005567764,0.4608221,0.00005743975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6078377,0.2190004,0.01163322,0.07918979,0.01956044,0.0002561753,0.002880423,0.002496812,0.0571451],"genre_scores_gemma":[0.8712181,0.05964466,0.002401244,0.01960831,0.003686539,0.0001460637,0.00136405,0.00008515963,0.04184595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002775176,"threshold_uncertainty_score":0.009283841,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4410816810","doi":"10.1158/2643-3230.bcd-25-0049","title":"Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Heart, Lung, and Blood Institute; Division of Cancer Prevention, National Cancer Institute","keywords":"Lymphoblastic Leukemia; Genomics; Biology; Medicine; Leukemia; Genetics; Oncology; Gene; Genome","authors":[{"name":"Haley Newman","is_ca":false},{"name":"Shawn H.R. Lee","is_ca":false},{"name":"Petri Pölönen","is_ca":false},{"name":"Rawan Shraim","is_ca":false},{"name":"Yimei Li","is_ca":false},{"name":"Hongyan Liu","is_ca":false},{"name":"Richard Aplenc","is_ca":false},{"name":"Shovik Bandyopadhyay","is_ca":false},{"name":"Changya Chen","is_ca":false},{"name":"Meenakshi Devidas","is_ca":false},{"name":"Caroline Diorio","is_ca":false},{"name":"Kimberly P. Dunsmore","is_ca":false},{"name":"Omar Elghawy","is_ca":false},{"name":"Amira Elhachimi","is_ca":false},{"name":"Sumit Gupta","is_ca":true},{"name":"Junior Hall","is_ca":false},{"name":"Andrew D. Hughes","is_ca":false},{"name":"Stephen P. Hunger","is_ca":false},{"name":"Mignon L. Loh","is_ca":false},{"name":"Zachary Martinez","is_ca":false},{"name":"Michael F. McCoy","is_ca":false},{"name":"Cassidy G. Mullen","is_ca":false},{"name":"Stanley Pounds","is_ca":false},{"name":"Elizabeth A. Raetz","is_ca":false},{"name":"Anna Eames Seffernick","is_ca":false},{"name":"Gongping Shi","is_ca":false},{"name":"Jonathan Sussman","is_ca":false},{"name":"Kai Tan","is_ca":false},{"name":"Lahari Uppuluri","is_ca":false},{"name":"Tiffaney L. Vincent","is_ca":false},{"name":"Ruth Wang’ondu","is_ca":false},{"name":"Lena E. Winestone","is_ca":false},{"name":"Stuart S. Winter","is_ca":false},{"name":"Brent L. Wood","is_ca":false},{"name":"Gang Wu","is_ca":false},{"name":"Jason Xu","is_ca":false},{"name":"Wenjian Yang","is_ca":false},{"name":"Charles G. Mullighan","is_ca":false},{"name":"Jun J. Yang","is_ca":false},{"name":"Kira Bona","is_ca":false},{"name":"David T. Teachey","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01471057760145185,"gpt":0.3150397892164973,"spread":0.3003292116150455,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0063404,0.0001967709,0.0004674196,0.0003435308,0.0004936177,0.001039126,0.0004789906,0.001393806,0.0008542622],"category_scores_gemma":[0.0264415,0.0001263603,0.0004656243,0.0005071476,0.00116382,0.0006716154,0.0006464035,0.00334534,0.0003024943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009336531,"about_ca_system_score_gemma":0.0006926499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004669471,"about_ca_topic_score_gemma":0.008006542,"domain_scores_codex":[0.9960543,0.002967593,0.0001315333,0.0003107134,0.0004091926,0.0001266503],"domain_scores_gemma":[0.9865453,0.01112033,0.0007202649,0.000404105,0.0008805442,0.0003296519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005297837,0.0001525068,0.2417191,0.0005172372,0.001252223,0.0007593543,0.000987631,0.00275341,0.002453617,0.006547411,0.2049785,0.5325811],"study_design_scores_gemma":[0.001408583,0.003365979,0.6585602,0.003131989,0.00349331,0.002667218,0.001823564,0.01978519,0.007022698,0.05938241,0.238961,0.0003978601],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.309112,0.0942217,0.003368544,0.573727,0.008159251,0.00005178625,0.001595006,0.0001797181,0.009584959],"genre_scores_gemma":[0.8463501,0.03815256,0.001678569,0.09363391,0.01688027,0.0000587236,0.0005057568,0.0001290576,0.00261113],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0063404,"threshold_uncertainty_score":0.03353167,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4415596352","doi":"10.1158/2643-3230.bcd-25-0130","title":"CD70-Targeting CAR NK Cells Overcome BCMA Downregulation and Improve Survival in High-risk Multiple Myeloma Models","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; Conquer Cancer Foundation; Marcus Foundation; Tanoto Foundation; Johns Hopkins University; Paula and Rodger Riney Foundation; Multiple Myeloma Research Foundation; American Society of Clinical Oncology; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Leukemia and Lymphoma Society; National Institutes of Health","keywords":"Multiple myeloma; Downregulation and upregulation; Cytotoxicity; Cell culture; Tumor cells","authors":[{"name":"Paul Lin","is_ca":false},{"name":"Sunil Acharya","is_ca":false},{"name":"Francia Reyes-Silva","is_ca":false},{"name":"Rafet Başar","is_ca":false},{"name":"Nadima Uprety","is_ca":false},{"name":"Luz Yurany Moreno Rueda","is_ca":false},{"name":"Pei Lin","is_ca":false},{"name":"April L. Gilbert","is_ca":false},{"name":"Pinaki P. Banerjee","is_ca":false},{"name":"Dexing Fang","is_ca":false},{"name":"Chenyu Zhang","is_ca":false},{"name":"Ana Karen Nunez Cortes","is_ca":false},{"name":"Luciana Melo Garcia","is_ca":true},{"name":"May Daher","is_ca":false},{"name":"Luis Muniz-Feliciano","is_ca":false},{"name":"Gary Deyter","is_ca":false},{"name":"Vernikka Woods","is_ca":false},{"name":"Seema Rawal","is_ca":false},{"name":"Ping Li","is_ca":false},{"name":"Corry M. Jones","is_ca":false},{"name":"Rejeena Shrestha","is_ca":false},{"name":"Muzaffar H. Qazilbash","is_ca":false},{"name":"Krina K. Patel","is_ca":false},{"name":"Hans C. Lee","is_ca":false},{"name":"Richard E. Champlin","is_ca":false},{"name":"David Marín","is_ca":false},{"name":"Elizabeth J. Shpall","is_ca":false},{"name":"Robert Z. Orlowski","is_ca":false},{"name":"Katayoun Rezvani","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01260320883669987,"gpt":0.2701118362164872,"spread":0.2575086273797873,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003479178,0.0003844324,0.0004326655,0.0002158873,0.0001934156,0.0004455494,0.0004482795,0.000560528,0.001314624],"category_scores_gemma":[0.0002335719,0.0001056032,0.000222151,0.0001213044,0.000379959,0.0003406868,0.0003528222,0.00207624,0.0004607495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008094287,"about_ca_system_score_gemma":0.0005564812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031453,"about_ca_topic_score_gemma":0.003967828,"domain_scores_codex":[0.9998117,0.00002727396,0.00001062192,0.00003055383,0.00006485746,0.00005507484],"domain_scores_gemma":[0.9998856,0.0000185551,0.00001909516,0.00001157685,0.0000381725,0.0000271326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001339736,0.0008065283,0.0007833088,0.0006055094,0.0001068362,0.0003619233,0.0001387237,0.00124979,0.8256157,0.004953705,0.03908123,0.124957],"study_design_scores_gemma":[0.001014728,0.003954756,0.007633781,0.0001076985,0.0002046436,0.001418557,0.0001249847,0.003551821,0.781293,0.00181891,0.1988276,0.00004963894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.842781,0.06823868,0.02170833,0.03352934,0.004130445,0.0005448098,0.001532225,0.002184304,0.02535084],"genre_scores_gemma":[0.9370707,0.02385121,0.006220725,0.005005458,0.0006725682,0.0002326163,0.0008318315,0.0001247199,0.02599017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314624,"threshold_uncertainty_score":0.005872846,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4410192422","doi":"10.1158/2643-3230.bcd-24-0240","title":"DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; Spinal Cord Injury BC; Canada's Michael Smith Genome Sciences Centre; Simon Fraser University","funders":"NHLBI Division of Intramural Research; National Cancer Institute; Canadian Institutes of Health Research; Pharmacyclics; EUSA Pharma; National Institute of Allergy and Infectious Diseases; MorphoSys; Terry Fox Research Institute; Michael Smith Health Research BC; Ministerio de Ciencia e Innovación; Canada's Michael Smith Genome Sciences Centre; Fundación Cellex; St. Jude Children's Research Hospital; Gilead Sciences; TG Therapeutics; Pfizer; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Amgen; Incyte; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"DNA methylation; Lymphoma; DNA; Burkitt's lymphoma; Methylation; Cancer research; Computational biology; Biology; Medicine; Genetics; Immunology; Gene; Gene expression","authors":[{"name":"Nicole Thomas","is_ca":true},{"name":"Carlos A. García‐Prieto","is_ca":false},{"name":"Kostiantyn Dreval","is_ca":true},{"name":"Laura K. Hilton","is_ca":true},{"name":"Jeremy S. Abramson","is_ca":false},{"name":"Nancy L. Bartlett","is_ca":false},{"name":"Jeffrey Bethony","is_ca":false},{"name":"Jay Bowen","is_ca":false},{"name":"Anthony C. Bryan","is_ca":false},{"name":"Corey Casper","is_ca":false},{"name":"Maureen A. Dyer","is_ca":false},{"name":"Julie M. Gastier‐Foster","is_ca":false},{"name":"Alina S. Gerrie","is_ca":true},{"name":"Timothy C. Greiner","is_ca":false},{"name":"Nicholas B. Griner","is_ca":false},{"name":"Thomas G. Gross","is_ca":false},{"name":"Nancy L. Harris","is_ca":false},{"name":"John D. Irvin","is_ca":false},{"name":"Elaine S. Jaffe","is_ca":false},{"name":"Fábio E. Leal","is_ca":false},{"name":"Sam M. Mbulaiteye","is_ca":false},{"name":"Charles G. Mullighan","is_ca":false},{"name":"Andrew J. Mungall","is_ca":true},{"name":"Karen Mungall","is_ca":true},{"name":"Constance Namirembe","is_ca":false},{"name":"Ariela Noy","is_ca":false},{"name":"Martin Ogwang","is_ca":false},{"name":"Jackson Orem","is_ca":false},{"name":"German Ott","is_ca":false},{"name":"Hilary Petrello","is_ca":false},{"name":"Steven J. Reynolds","is_ca":false},{"name":"Steven H. Swerdlow","is_ca":false},{"name":"Alexandra Traverse‐Glehen","is_ca":false},{"name":"Wyndham H. Wilson","is_ca":false},{"name":"Marco A. Marra","is_ca":true},{"name":"Louis M. Staudt","is_ca":false},{"name":"David W. Scott","is_ca":true},{"name":"Manel Esteller","is_ca":false},{"name":"Ryan D. Morin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009172808857633568,"gpt":0.3035139083737359,"spread":0.2943410995161023,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338133,0.0001772761,0.0002176552,0.0007043928,0.0002249511,0.0003339769,0.0001262626,0.0001895923,0.001429543],"category_scores_gemma":[0.001014472,0.00011697,0.0001575369,0.0005091762,0.0002553767,0.0002061571,0.0005226401,0.0001872898,0.0001588528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729552,"about_ca_system_score_gemma":0.0001183914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001342051,"about_ca_topic_score_gemma":0.002057436,"domain_scores_codex":[0.9998477,0.00003897108,0.00001906339,0.00003905025,0.00002367433,0.00003155053],"domain_scores_gemma":[0.9995748,0.00009559271,0.0001879732,0.00005147352,0.00004713652,0.00004292079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004059524,0.00001290684,0.9631413,0.00002453656,0.00005221841,0.0003623276,0.0002635791,0.0001271663,0.0264285,0.00009333374,0.00007311659,0.009015032],"study_design_scores_gemma":[0.00001054837,0.000100945,0.9942617,0.000008116284,0.00003475426,0.002730401,0.0003735175,0.000387047,0.001453364,0.0002469157,0.0003869741,0.000005758046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991303,0.0001693158,0.0002551135,0.00001713449,9.346254e-7,0.000007205196,0.000117824,0.000005676318,0.0002964087],"genre_scores_gemma":[0.9994998,0.00004817604,0.000164461,0.00001145795,0.000001967087,0.000005193935,0.0001814334,0.000002202321,0.00008523017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429543,"threshold_uncertainty_score":0.004782259,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4248313354","doi":"10.1158/2643-3249.bcd-19-0039","title":"Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on <i>MIR300</i> Antiproliferative and PP2A-Activating Functions","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"National Institutes of Health; Cancer Research Society; National Natural Science Foundation of China; American Cyronics Society; U.S. Department of Defense","keywords":"Progenitor cell; Protein phosphatase 2; Cancer research; Biology; Immune system; Stem cell; Immunology; Leukemia; Apoptosis; Cell biology; Phosphatase; Phosphorylation","authors":[{"name":"Giovannino Silvestri","is_ca":false},{"name":"Rossana Trotta","is_ca":false},{"name":"Lorenzo Stramucci","is_ca":false},{"name":"Justin J. Ellis","is_ca":false},{"name":"Jason G. Harb","is_ca":false},{"name":"Paolo Neviani","is_ca":false},{"name":"Shuzhen Wang","is_ca":false},{"name":"Ann‐Kathrin Eisfeld","is_ca":false},{"name":"Christopher J. Walker","is_ca":false},{"name":"Bin Zhang","is_ca":false},{"name":"Klára Šrůtová","is_ca":false},{"name":"Carlo Gambacorti‐Passerini","is_ca":false},{"name":"Gabriel Pineda","is_ca":false},{"name":"Catriona Jamieson","is_ca":false},{"name":"Fabio Stagno","is_ca":false},{"name":"Paolo Vigneri","is_ca":false},{"name":"Georgios Nteliopoulos","is_ca":false},{"name":"Philippa C. May","is_ca":false},{"name":"Alistair Reid","is_ca":false},{"name":"Ramiro Garzon","is_ca":false},{"name":"Denis‐Claude Roy","is_ca":true},{"name":"Moutuaata M. Moutuou","is_ca":true},{"name":"Martin Guimond","is_ca":true},{"name":"Peter Hokland","is_ca":false},{"name":"Michael W. Deininger","is_ca":false},{"name":"Garrett Fitzgerald","is_ca":false},{"name":"Christopher Harman","is_ca":false},{"name":"Francesco Dazzi","is_ca":false},{"name":"Dragana Milojković","is_ca":false},{"name":"Jane F. Apperley","is_ca":false},{"name":"Guido Marcucci","is_ca":false},{"name":"Jianfei Qi","is_ca":false},{"name":"Kateřina Machová Poláková","is_ca":false},{"name":"Ying Zou","is_ca":false},{"name":"Xiaoxuan Fan","is_ca":false},{"name":"Maria R. Baer","is_ca":false},{"name":"Bruno Calabretta","is_ca":false},{"name":"Danilo Perrotti","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01585045797614332,"gpt":0.2071715928590338,"spread":0.1913211348828905,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007849424,0.0001677018,0.0002199553,0.0001725026,0.0001425486,0.0002325533,0.00008761321,0.0001531403,0.001284371],"category_scores_gemma":[0.0001037005,0.00009573728,0.0001498223,0.0001248058,0.0001399339,0.00009862466,0.0001038858,0.0003899942,0.000291327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017503,"about_ca_system_score_gemma":0.00014143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002852695,"about_ca_topic_score_gemma":0.0004317187,"domain_scores_codex":[0.9999304,0.000007462662,0.00000727078,0.00001760738,0.00002194457,0.00001528945],"domain_scores_gemma":[0.9999517,0.000006558615,0.00001741973,0.000005340472,0.000004187349,0.00001485267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006420716,0.00008053362,0.007335328,0.00003369535,0.00001335999,0.0002293118,0.00003067347,0.00009013552,0.9796229,0.0001375378,0.0002072693,0.01157721],"study_design_scores_gemma":[0.00009457803,0.001360957,0.1161719,0.000008883203,0.00006740634,0.004041061,0.0000719059,0.001051552,0.8703578,0.0002300842,0.006531092,0.00001273558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964364,0.001263231,0.0007437398,0.00007104101,0.000009904102,0.00001795941,0.0002451206,0.00006994669,0.001142724],"genre_scores_gemma":[0.9980981,0.0003343976,0.0004601075,0.00005016076,0.000006872735,0.00001868722,0.0003655069,0.000007375092,0.0006588501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284371,"threshold_uncertainty_score":0.004296601,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4412119851","doi":"10.1158/2643-3230.bcd-24-0327","title":"An Isoform-Specific RUNX1C–BTG2 Axis Governs AML Quiescence and Chemoresistance","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of General Medical Sciences; Leukemia Research Foundation; National Cancer Institute; National Heart, Lung, and Blood Institute; Foundation for the National Institutes of Health; Butler Family Foundation","keywords":"Gene isoform; Cancer research; Biology; Myeloid leukemia; RNA; Transcription factor; Transcription (linguistics); Messenger RNA; Promoter; Chemotherapy; Molecular biology; Gene expression; Gene; Genetics","authors":[{"name":"Cuijuan Han","is_ca":false},{"name":"Zhiping Zhang","is_ca":false},{"name":"Edie I. Crosse","is_ca":false},{"name":"Sogand Sajedi","is_ca":false},{"name":"Bin Lü","is_ca":false},{"name":"Xiyue Wang","is_ca":false},{"name":"Sadik Karma","is_ca":false},{"name":"Mitch Kostich","is_ca":false},{"name":"Sakthi H. Rajendran","is_ca":false},{"name":"Dylan B. Udy","is_ca":false},{"name":"Steven Chen","is_ca":false},{"name":"Alexander Calderon","is_ca":false},{"name":"Abimbola Eunice. Lawal","is_ca":false},{"name":"Patrick K. Reville","is_ca":false},{"name":"Hussein A. Abbas","is_ca":false},{"name":"Omar Abdel‐Wahab","is_ca":false},{"name":"Pedro Miura","is_ca":false},{"name":"Robert K. Bradley","is_ca":false},{"name":"Eric Wang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00470263058249781,"gpt":0.2435911064997337,"spread":0.2388884759172359,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341207,0.0001904295,0.0001817467,0.0001955059,0.0001490332,0.0002952196,0.0001258745,0.0001773067,0.0009098558],"category_scores_gemma":[0.0001280612,0.00008578107,0.0001226919,0.0001793456,0.0002787042,0.0001276753,0.0001571444,0.0002993411,0.0001544567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000573942,"about_ca_system_score_gemma":0.0003796747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009163491,"about_ca_topic_score_gemma":0.002056177,"domain_scores_codex":[0.9999062,0.000009534451,0.000004074715,0.00002836695,0.00003006764,0.00002182545],"domain_scores_gemma":[0.9999491,0.00000520092,0.00002105391,0.000004745795,0.000007555474,0.0000123367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060855,0.000007623644,0.002221173,0.00001658201,0.000004062412,0.00003750654,0.00001558848,0.000123978,0.993607,0.0003353324,0.0000614503,0.00346352],"study_design_scores_gemma":[0.00004738631,0.0003236587,0.08789738,0.0000142942,0.00003900179,0.0006831649,0.0001119942,0.003643108,0.8971401,0.0006178941,0.009469439,0.00001254425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902664,0.002509405,0.003694392,0.0003087609,0.00002003085,0.00003184798,0.0006154448,0.0001331506,0.00242047],"genre_scores_gemma":[0.9969797,0.0005032617,0.0008016645,0.00006554872,0.00000807238,0.00001468508,0.0003316682,0.00001634792,0.001279025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009163491,"threshold_uncertainty_score":0.004164279,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4417055360","doi":"10.1158/2643-3230.bcd-25-0246","title":"Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"AstraZeneca (Canada)","funders":"HCA International Foundation; Wellcome Trust; Nationales Centrum für Tumorerkrankungen Heidelberg; Wilhelm Sander-Stiftung; José Carreras Leukämie-Stiftung; Joachim Herz Stiftung; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum","keywords":"Juvenile myelomonocytic leukemia; Reprogramming; Fetus; Mutation; Gene; PTPN11; Leukemia","authors":[{"name":"Mark Hartmann","is_ca":false},{"name":"Maximilian Schönung","is_ca":false},{"name":"Jovana Rajak","is_ca":false},{"name":"Valentin Maurer","is_ca":false},{"name":"Ling Hai","is_ca":false},{"name":"Katharina Bauer","is_ca":false},{"name":"Mariam Hakobyan","is_ca":false},{"name":"Sina Stäble","is_ca":false},{"name":"Jens Langstein","is_ca":true},{"name":"Laura Jardine","is_ca":false},{"name":"Roland Roelz","is_ca":false},{"name":"Sheila Bohler","is_ca":false},{"name":"Eleonora Khabirova","is_ca":false},{"name":"Abdul‐Habib Maag","is_ca":false},{"name":"Dominik Vonficht","is_ca":false},{"name":"Dirk Lebrecht","is_ca":false},{"name":"Kathrin M. Bernt","is_ca":false},{"name":"Kai Tan","is_ca":false},{"name":"Changya Chen","is_ca":false},{"name":"Fatemeh Alikarami‬","is_ca":false},{"name":"Julia Meyer","is_ca":false},{"name":"Tobias Boch","is_ca":false},{"name":"Viktoria Flore","is_ca":false},{"name":"Pavlo Lutsik","is_ca":false},{"name":"Michael D. Milsom","is_ca":false},{"name":"Simon Raffel","is_ca":false},{"name":"Christian Buske","is_ca":false},{"name":"Simon Haas","is_ca":false},{"name":"Muzlifah Haniffa","is_ca":false},{"name":"Jan‐Philipp Mallm","is_ca":false},{"name":"Sam Behjati","is_ca":false},{"name":"Marc Jan Bonder","is_ca":false},{"name":"Stefan Fröhling","is_ca":false},{"name":"Elliot Stieglitz","is_ca":false},{"name":"Charlotte M. Niemeyer","is_ca":false},{"name":"Joschka Hey","is_ca":false},{"name":"Christian Flotho","is_ca":false},{"name":"Christoph Plass","is_ca":false},{"name":"Miriam Erlacher","is_ca":false},{"name":"Matthias Schlesner","is_ca":false},{"name":"Daniel B. Lipka","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01672271983316454,"gpt":0.30993910152471,"spread":0.2932163816915455,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005899461,0.0002460967,0.0002086233,0.0002501791,0.0002551305,0.0005967179,0.0002728428,0.0009687339,0.001110646],"category_scores_gemma":[0.0005056715,0.0001037736,0.000188058,0.0001902342,0.0007253714,0.0005040406,0.0004462345,0.002729574,0.0004318113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007778287,"about_ca_system_score_gemma":0.0002922771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295417,"about_ca_topic_score_gemma":0.001258233,"domain_scores_codex":[0.9997546,0.00005011987,0.0000148444,0.00004641988,0.00009671376,0.00003725158],"domain_scores_gemma":[0.9998079,0.00009591721,0.00002050282,0.00001150037,0.00003549275,0.00002871121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007538556,0.0001560107,0.002701696,0.0007835304,0.00006969986,0.003324968,0.0003281359,0.0006333521,0.3287026,0.05815148,0.2367664,0.3676283],"study_design_scores_gemma":[0.0001029737,0.0004149185,0.006842745,0.0002151386,0.00007309289,0.004331158,0.0002089772,0.0008958761,0.09699807,0.01411818,0.8757608,0.00003805087],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1721073,0.4630403,0.01318585,0.2707521,0.02557063,0.0001614823,0.0009145408,0.001243082,0.05302474],"genre_scores_gemma":[0.5265089,0.2933819,0.004285266,0.08509371,0.01986358,0.0001704778,0.0004904455,0.000173966,0.07003175],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001110646,"threshold_uncertainty_score":0.005643547,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4294771401","doi":"10.1158/2643-3249.lymphoma22-a19","title":"Abstract A19: Integrated single cell analysis reveals co-evolution of malignant B cells and the tumor microenvironment in transformed follicular lymphoma","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Biology; Diffuse large B-cell lymphoma; Follicular lymphoma; Transcriptome; Lymphoma; Somatic evolution in cancer; Tumor microenvironment; Cancer research; Phenotype; Cancer; Genetics; Gene; Immunology; Tumor cells; Gene expression","authors":[{"name":"Clémentine Sarkozy","is_ca":false},{"name":"Shaocheng Wu","is_ca":true},{"name":"Katsuyoshi Takata","is_ca":true},{"name":"Tomohiro Aoki","is_ca":true},{"name":"Susana Ben Neriah","is_ca":true},{"name":"Katy Milne","is_ca":true},{"name":"Brad H. Nelson","is_ca":true},{"name":"Andrew P. Weng","is_ca":true},{"name":"D. S. Scott","is_ca":true},{"name":"Jeffrey W. Craig","is_ca":true},{"name":"Christian Steidl","is_ca":true},{"name":"Andrew Roth","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006782715877148441,"gpt":0.2155351354521206,"spread":0.2087524195749721,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126398,0.0001281307,0.0001837755,0.0003693138,0.0001463848,0.0003358063,0.0001421983,0.0002136701,0.001291026],"category_scores_gemma":[0.0001523845,0.00009210985,0.0001424422,0.0002437489,0.0001417871,0.0001005882,0.0001530903,0.0002065654,0.0004416498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001841175,"about_ca_system_score_gemma":0.0000749543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007659335,"about_ca_topic_score_gemma":0.0007714741,"domain_scores_codex":[0.9998853,0.00001109991,0.00000707197,0.00004000657,0.00003309482,0.00002343035],"domain_scores_gemma":[0.9998999,0.00001957375,0.00001787306,0.00001550583,0.00002099014,0.0000261693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008858595,0.000008526864,0.00329776,0.000008577807,0.000003948868,0.00005494691,0.0000208611,0.00006436295,0.9953455,0.00001776877,0.00001982431,0.001069316],"study_design_scores_gemma":[0.00002122347,0.0004957819,0.2208412,0.000004436994,0.00004508417,0.001357243,0.0001874409,0.007621916,0.766839,0.0001558588,0.002419041,0.0000119018],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9955128,0.0001465121,0.003312937,0.00001510402,0.000005528972,0.00001032401,0.0005667477,0.00006726359,0.0003626953],"genre_scores_gemma":[0.9948941,0.00006284239,0.003302181,0.00001857295,0.000005173735,0.00001830186,0.001133958,0.00001968009,0.0005450974],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001291026,"threshold_uncertainty_score":0.004318953,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3108449195","doi":"10.1158/2643-3249.lymphoma20-po-32","title":"Abstract PO-32: NFKBIZ 3′ UTR mutations confer selective growth advantage and affect drug response in diffuse large B-cell lymphoma","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Occupational Cancer Research Centre; Spinal Cord Injury BC; Canadian Centre for Applied Research in Cancer Control; Simon Fraser University","funders":"","keywords":"Diffuse large B-cell lymphoma; Untranslated region; Biology; Mutation; Three prime untranslated region; Cancer research; Mutant; Cell growth; Signal transduction; CRISPR; Gene; Genetics; Lymphoma; Messenger RNA; Molecular biology; Immunology","authors":[{"name":"Sarah E. Arthur","is_ca":true},{"name":"Nicole Thomas","is_ca":true},{"name":"Jeffrey Tang","is_ca":true},{"name":"Christopher Rushton","is_ca":true},{"name":"Miguel Alcaide","is_ca":true},{"name":"Adèle Telenius","is_ca":true},{"name":"Shannon Healy","is_ca":true},{"name":"Anja Mottok","is_ca":true},{"name":"David W. Scott","is_ca":true},{"name":"Christian Steidl","is_ca":true},{"name":"Ryan D. Morin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009652214431649287,"gpt":0.2629226390862386,"spread":0.2532704246545894,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021626,0.0002178109,0.0001783577,0.0002018123,0.0001276225,0.0001522321,0.0001456755,0.0002995606,0.002385259],"category_scores_gemma":[0.00009034783,0.00008772582,0.000193147,0.0001269089,0.0002241561,0.00008382081,0.0001549457,0.0004110239,0.0005533809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700473,"about_ca_system_score_gemma":0.0001245394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006414852,"about_ca_topic_score_gemma":0.0005892593,"domain_scores_codex":[0.999903,0.00001552364,0.00001201985,0.00002248926,0.0000231928,0.00002373114],"domain_scores_gemma":[0.9999038,0.00002160013,0.00002187378,0.000011411,0.000005913043,0.00003534263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002239373,0.00009258615,0.0009239932,0.00001543456,0.000005065443,0.0002652151,0.00001096633,0.00008965896,0.9970182,0.00007868805,0.00005037005,0.00122587],"study_design_scores_gemma":[0.0001656692,0.001749157,0.032082,0.000008666647,0.00004173525,0.005087562,0.00006104285,0.002190433,0.9542233,0.0001287509,0.004247986,0.00001365881],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977973,0.0001514972,0.0006092109,0.00004324214,0.00001022974,0.00002342597,0.0003360574,0.00003816859,0.0009909234],"genre_scores_gemma":[0.9980505,0.00007038286,0.0005760849,0.00003205892,0.000003028741,0.00002192994,0.0003229223,0.00001417784,0.0009089267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002385259,"threshold_uncertainty_score":0.007979512,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3108297018","doi":"10.1158/2643-3249.lymphoma20-po-22","title":"Abstract PO-22: Compromised counterselection by FAS creates a lethal subtype of germinal center lymphoma","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Germinal center; Fas ligand; Biology; Apoptosis; Cancer research; B cell; Lymphoma; Programmed cell death; Immunology; Genetics; Antibody","authors":[{"name":"Raud Razzaghi","is_ca":false},{"name":"Shreya Agarwal","is_ca":false},{"name":"Nikita Kotlov","is_ca":false},{"name":"Olga Plotnikova","is_ca":false},{"name":"Krystle Nomie","is_ca":false},{"name":"Da Wei Huang","is_ca":false},{"name":"George W. Wright","is_ca":false},{"name":"Moyi Li","is_ca":false},{"name":"Katsuyoshi Takata","is_ca":true},{"name":"Chen Yao","is_ca":false},{"name":"John J. O’Shea","is_ca":false},{"name":"James D. Phelan","is_ca":false},{"name":"Stefania Pittaluga","is_ca":false},{"name":"David W. Scott","is_ca":true},{"name":"Jagan Muppidi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01587235240195315,"gpt":0.2583213546670012,"spread":0.2424490022650481,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008361867,0.0002948593,0.0002151331,0.0004152989,0.0001611585,0.0003652728,0.0001901096,0.0003103929,0.003145614],"category_scores_gemma":[0.0001366957,0.0001096817,0.0001370562,0.0002136364,0.0002602586,0.0001988945,0.0003245977,0.0005720955,0.0006074833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845147,"about_ca_system_score_gemma":0.0001271634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002859911,"about_ca_topic_score_gemma":0.0003660863,"domain_scores_codex":[0.9998161,0.00002335921,0.00001509643,0.0000506258,0.00005318999,0.00004161415],"domain_scores_gemma":[0.9998702,0.00001650301,0.00003716043,0.00001767919,0.000007857636,0.00005055659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003007748,0.0000812369,0.003272758,0.00003865878,0.00001693436,0.001824935,0.00004351596,0.00009828569,0.9888045,0.0003703473,0.0002035859,0.004944361],"study_design_scores_gemma":[0.0001039016,0.001263702,0.05098371,0.00001648719,0.00006135162,0.03134402,0.0002126899,0.001456397,0.9039857,0.0004288112,0.01012774,0.00001548495],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968913,0.0003067588,0.001108122,0.00006583162,0.00001519497,0.00002162781,0.0002712274,0.00009337137,0.001226587],"genre_scores_gemma":[0.9971009,0.0001365028,0.0004433222,0.00002988485,0.000005429087,0.00001226031,0.0003769597,0.0000224391,0.001872244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003145614,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4367603727","doi":"10.1158/2643-3249.aml23-a54","title":"Abstract A54: Polyamines are required for AML LSC function through their role in regulating eIF5A dependent protein synthesis","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Arginine; Haematopoiesis; Myeloid leukemia; Stem cell; Progenitor cell; Biology; Leukemia; Cancer research; Polyamine; Metabolite; Biochemistry; Myeloid; Cell biology; Immunology; Amino acid","authors":[{"name":"Vincent Rondeau","is_ca":true},{"name":"Cristiana O’Brien","is_ca":true},{"name":"Jacob M. Berman","is_ca":true},{"name":"Duhan Yendi","is_ca":true},{"name":"Tianyi Ling","is_ca":true},{"name":"Aleksandra Bourdine","is_ca":true},{"name":"Aarushi Gupta","is_ca":true},{"name":"Jonathan St‐Germain","is_ca":true},{"name":"Rachel Culp‐Hill","is_ca":false},{"name":"Julie A. Reisz","is_ca":false},{"name":"Soheil Jahangiri","is_ca":true},{"name":"Anastasia N. Tikhonova","is_ca":true},{"name":"Andrea Arruda","is_ca":true},{"name":"Mark D. Minden","is_ca":true},{"name":"Angelo D’Alessandro","is_ca":false},{"name":"Brian Raught","is_ca":true},{"name":"Courtney L. Jones","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01811990868516516,"gpt":0.2624131206114914,"spread":0.2442932119263262,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000815376,0.000206031,0.0002107639,0.0001405214,0.0002150367,0.0003362335,0.000145181,0.0002932906,0.006192576],"category_scores_gemma":[0.0001309795,0.00008615424,0.0002438331,0.0001489433,0.000178909,0.0001946527,0.000201926,0.0004612366,0.0009465939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177577,"about_ca_system_score_gemma":0.0002414935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006757788,"about_ca_topic_score_gemma":0.0009029412,"domain_scores_codex":[0.9999017,0.00000908117,0.00001192111,0.00003019391,0.00003009564,0.00001709625],"domain_scores_gemma":[0.9999003,0.0000128326,0.00003072078,0.000009060949,0.00001494931,0.0000321366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003522792,0.00002158557,0.0008775198,0.00004850449,0.000006389111,0.00009529117,0.00001058582,0.00004450675,0.9956428,0.00006868391,0.0002420368,0.002589752],"study_design_scores_gemma":[0.00004612351,0.0005270697,0.04182289,0.00002260325,0.00003425658,0.0006334537,0.00007433193,0.0006711399,0.9444575,0.0001322106,0.01157156,0.000006899626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870249,0.003361526,0.002260933,0.0004581976,0.0001284328,0.00003193484,0.002946927,0.0002010732,0.003586011],"genre_scores_gemma":[0.9901939,0.0009438097,0.001542703,0.0002053424,0.00001930569,0.00002883019,0.002601383,0.00003612848,0.004428566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006192576,"threshold_uncertainty_score":0.02071619,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4294919189","doi":"10.1158/2643-3230.bcd-22-0120","title":"Q&amp;A: John Dick on Stem Cells and Discoveries","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"","funders":"","keywords":"Stem cell; Environmental ethics; Biology; Philosophy; Cell biology","authors":[],"retraction":null,"screen_n_in":null,"score":{"opus":0.02585182521845221,"gpt":0.2791861573553381,"spread":0.2533343321368859,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005482185,0.001093708,0.0009435527,0.001952487,0.003302134,0.01111088,0.00180823,0.007243979,0.09843034],"category_scores_gemma":[0.01418704,0.0005814823,0.0008441174,0.001320093,0.00499158,0.007567495,0.003590703,0.01005689,0.05129486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004694652,"about_ca_system_score_gemma":0.005948877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004089621,"about_ca_topic_score_gemma":0.007302191,"domain_scores_codex":[0.9942476,0.0008668106,0.0002652598,0.000951349,0.00316652,0.0005025198],"domain_scores_gemma":[0.9872983,0.003409747,0.0004416866,0.0005358034,0.004039201,0.00427536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001138091,0.000009511209,0.00003462873,0.00005641063,0.000003124197,0.00004005346,0.00003927873,0.00003290372,0.0001266762,0.008084613,0.9736313,0.01793021],"study_design_scores_gemma":[0.000005322106,0.000009544673,0.00006733257,0.00009948234,9.668023e-7,0.00004091642,0.0000439178,0.00003192165,0.00005562324,0.004819041,0.9948198,0.000006187561],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.0004425822,0.08605249,0.003464024,0.5022713,0.2135258,0.0001474898,0.0003244508,0.0005706552,0.1932012],"genre_scores_gemma":[0.004707755,0.05428167,0.002288424,0.1847914,0.07532677,0.000145729,0.000211563,0.0005987973,0.6776479],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.09843034,"threshold_uncertainty_score":0.3292823,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3107639073","doi":"10.1158/2643-3249.lymphoma20-po-62","title":"Abstract PO-62: Overcoming venetoclax resistance in B-cell malignancies by antagonism of stromal TGF-beta-mediated drug resistance","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Stromal cell; Cancer research; Tumor microenvironment; Stroma; Venetoclax; Drug resistance; Biology; Leukemia; Medicine; Immunology; Chemistry; Chronic lymphocytic leukemia; Tumor cells","authors":[{"name":"Eugene Park","is_ca":false},{"name":"Jingyu Chen","is_ca":false},{"name":"A. P. Moore","is_ca":false},{"name":"Maurizio Mangolini","is_ca":false},{"name":"Joseph R. Byod","is_ca":false},{"name":"Hilde Schjerven","is_ca":false},{"name":"James C. Williamson","is_ca":false},{"name":"Paul J. Lehner","is_ca":false},{"name":"Michael Leitges","is_ca":true},{"name":"Alexander Egle","is_ca":false},{"name":"Marc Schmidt‐Supprian","is_ca":false},{"name":"Seth Frietze","is_ca":false},{"name":"Ingo Ringshausen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01165107891578242,"gpt":0.245988149186268,"spread":0.2343370702704856,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009171719,0.0002266735,0.0001916243,0.0002103844,0.0001226051,0.0002867575,0.0001619808,0.0001566086,0.002233829],"category_scores_gemma":[0.00006127449,0.00007680873,0.0001439702,0.0001504345,0.0001587901,0.0001353411,0.000123969,0.0008930933,0.0004515314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001289484,"about_ca_system_score_gemma":0.0002474095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005363789,"about_ca_topic_score_gemma":0.0009805537,"domain_scores_codex":[0.9999474,0.000007565996,0.000003486057,0.000008867726,0.00001378733,0.00001881732],"domain_scores_gemma":[0.9999706,0.000004400675,0.000006309299,0.000003794965,0.000002960075,0.00001199257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005368409,0.0003959347,0.0003906036,0.0001056015,0.00001346475,0.00008634292,0.00002379519,0.0002720044,0.9802148,0.0003559237,0.0004965229,0.01710808],"study_design_scores_gemma":[0.0003841325,0.005212266,0.007538442,0.00002800271,0.00005998951,0.0007580583,0.00005856299,0.002731763,0.9655204,0.0001972161,0.01750086,0.00001039888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878013,0.004052036,0.001511058,0.0003135431,0.0001038186,0.00008841209,0.0003312004,0.0001495927,0.005648922],"genre_scores_gemma":[0.9929449,0.001735152,0.00122602,0.00009214864,0.0000261901,0.00004125479,0.0003990375,0.00001355137,0.003521811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002233829,"threshold_uncertainty_score":0.007472932,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3110575363","doi":"10.1158/2643-3249.lymphoma20-po-26","title":"Abstract PO-26: Prognostic significance of Fc gamma receptor IIB expression in the response of previously untreated diffuse large B-cell lymphomas to anti-CD20 monoclonal antibodies: Differing impact of rituximab and obinutuzumab","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Simon Fraser University; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"Rituximab; International Prognostic Index; CHOP; CD20; Tissue microarray; Immunohistochemistry; Lymphoma; Medicine; Diffuse large B-cell lymphoma; Monoclonal antibody; Cancer research; Internal medicine; Oncology; Antibody; Immunology","authors":[{"name":"Laura K. Hilton","is_ca":true},{"name":"Małgorzata Nowicka","is_ca":false},{"name":"Margaret Ashton‐Key","is_ca":false},{"name":"Chantal E. Hargreaves","is_ca":false},{"name":"Chern Siang Lee","is_ca":false},{"name":"Russell B. Foxall","is_ca":false},{"name":"Matthew Carter","is_ca":false},{"name":"Stephen A. Beers","is_ca":false},{"name":"Kathleen N. Potter","is_ca":false},{"name":"Christopher R. Bolen","is_ca":false},{"name":"Christian Klein","is_ca":false},{"name":"Andrea Knapp","is_ca":false},{"name":"Farheen Mir","is_ca":false},{"name":"Matthew Rose‐Zerilli","is_ca":false},{"name":"Cathy Burton","is_ca":false},{"name":"Wolfgang Hiddemann","is_ca":false},{"name":"David W. Scott","is_ca":true},{"name":"Laurie H. Sehn","is_ca":true},{"name":"Umberto Vitolo","is_ca":false},{"name":"Maurizio Martelli","is_ca":false},{"name":"Marek Trněný","is_ca":false},{"name":"Graham W. Slack","is_ca":true},{"name":"Pedro Farinha","is_ca":true},{"name":"Jonathan C. Strefford","is_ca":false},{"name":"Mikkel Z. Oestergaard","is_ca":false},{"name":"Ryan D. Morin","is_ca":true},{"name":"Mark S. Cragg","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02231961598826306,"gpt":0.3019578942477443,"spread":0.2796382782594812,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003884872,0.0001709585,0.0002818153,0.0002701575,0.0001383818,0.0005571433,0.0001939249,0.0002587267,0.001851888],"category_scores_gemma":[0.0007137634,0.00009398444,0.0002427954,0.0003055018,0.0002354481,0.000192746,0.0001682627,0.0003369419,0.0004081975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002365335,"about_ca_system_score_gemma":0.0001282314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000303293,"about_ca_topic_score_gemma":0.0003699859,"domain_scores_codex":[0.9998083,0.00004828489,0.00001490763,0.0000662481,0.00002805677,0.00003428117],"domain_scores_gemma":[0.9995646,0.00009571944,0.000190369,0.00002384757,0.00003713724,0.00008826586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01451811,0.0002115471,0.9454099,0.0001058516,0.0002504782,0.0002022886,0.00008902553,0.0003819023,0.0213636,0.00005791029,0.0006063159,0.01680311],"study_design_scores_gemma":[0.000198948,0.001240079,0.9917796,0.00001781965,0.0002072223,0.0004808533,0.0001102208,0.0008504326,0.003774995,0.0001029932,0.001228164,0.000008692078],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986231,0.0005573397,0.0001170469,0.00002415914,0.000006150586,0.00001163706,0.0003163992,0.000005271613,0.0003388597],"genre_scores_gemma":[0.9990513,0.00008049849,0.00008267967,0.0000259652,0.00001054932,0.00001594884,0.0005147167,0.000003109339,0.0002151701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851888,"threshold_uncertainty_score":0.006195188,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4367553368","doi":"10.1158/2643-3249.aml23-ia03","title":"Abstract IA03: Inducing apoptosis in leukemia stem cells by targeting metabolism","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network","funders":"","keywords":"Myeloid leukemia; Leukemia; Cancer research; Stem cell; Apoptosis; Medicine; Cancer; Population; Disease; Myelodysplastic syndromes; Cancer stem cell; Immunology; Biology; Bone marrow; Internal medicine; Cell biology; Genetics","authors":[{"name":"Courtney L. Jones","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02077000338986654,"gpt":0.2875100773813973,"spread":0.2667400739915307,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248947,0.0003854813,0.0002966775,0.0005737517,0.000286563,0.00107504,0.0004371206,0.0005027801,0.008946326],"category_scores_gemma":[0.0001899717,0.0001762732,0.0003697967,0.0005928599,0.0002570804,0.0002354667,0.0003508173,0.0009101281,0.002891564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007863194,"about_ca_system_score_gemma":0.0007542626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186622,"about_ca_topic_score_gemma":0.001808934,"domain_scores_codex":[0.9998852,0.00001906313,0.00001044154,0.00001905015,0.00004001113,0.00002613087],"domain_scores_gemma":[0.999904,0.00001368837,0.00002090235,0.00001566069,0.00001725922,0.00002846086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002490215,0.0009488463,0.001979874,0.0005331027,0.00006506366,0.0005634933,0.0000735459,0.001849281,0.744286,0.01053819,0.05041807,0.1862544],"study_design_scores_gemma":[0.0006587008,0.002704015,0.008878454,0.0001300856,0.00009246087,0.002085319,0.0000708551,0.003053389,0.7774523,0.001872664,0.2029687,0.00003308388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6893656,0.05486562,0.01465214,0.01043035,0.00347143,0.0008159059,0.01239721,0.004461005,0.2095409],"genre_scores_gemma":[0.9017459,0.02127842,0.009068992,0.002023784,0.0003013049,0.0002491826,0.005960869,0.0002211097,0.05915045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008946326,"threshold_uncertainty_score":0.02992845,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4294775244","doi":"10.1158/2643-3249.lymphoma22-a24","title":"Abstract A24: <i>BTG1</i> mutations confer a fitness advantage and promote aggressive B cell lymphoma development by lowering the threshold for MYC induction","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Biology; Germinal center; Lymphoma; Cancer research; Mutation; B cell; Immunology; Genetics; Gene; Antibody","authors":[{"name":"Coraline Mlynarczyk","is_ca":false},{"name":"Matt Teater","is_ca":false},{"name":"Juhee Pae","is_ca":false},{"name":"Ling Wang","is_ca":false},{"name":"Jonatan Ersching","is_ca":false},{"name":"Antonin Papin","is_ca":false},{"name":"Darko Barišić","is_ca":false},{"name":"Ersilia Barin","is_ca":false},{"name":"Kenneth B. Hoehn","is_ca":false},{"name":"Zhengming Chen","is_ca":false},{"name":"Diu Nguyen","is_ca":false},{"name":"Chiara M. Evans","is_ca":false},{"name":"Ashley S. Doane","is_ca":false},{"name":"Michael G. Kharas","is_ca":false},{"name":"David W. Scott","is_ca":true},{"name":"Gabriel D. Victora","is_ca":false},{"name":"Ari Melnick","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00733294582110307,"gpt":0.2367027978724541,"spread":0.229369852051351,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126104,0.0003052628,0.0001974806,0.0003510922,0.0001574229,0.0003086637,0.000176749,0.0002907354,0.005047821],"category_scores_gemma":[0.0001161231,0.00008874695,0.0002447092,0.0002241324,0.0002485591,0.0001106359,0.0002107146,0.0005587901,0.0006518715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003118288,"about_ca_system_score_gemma":0.0001420328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320908,"about_ca_topic_score_gemma":0.001238219,"domain_scores_codex":[0.9998479,0.00001914059,0.00001104506,0.00004243909,0.00004103782,0.00003846904],"domain_scores_gemma":[0.9998723,0.00001372786,0.00004390436,0.00001040142,0.00000891745,0.00005075608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002327608,0.00003509323,0.002519512,0.00001862902,0.00001485285,0.00008439489,0.00000967503,0.00008230217,0.9953695,0.00008990217,0.0001776149,0.001365687],"study_design_scores_gemma":[0.00008503498,0.001272938,0.1627281,0.00001730116,0.00009296391,0.003104931,0.0001139117,0.002438385,0.821322,0.0003352574,0.008472715,0.00001647567],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9965714,0.0002758705,0.0009198096,0.0001092979,0.00001598104,0.00001327263,0.001204924,0.0001038389,0.0007854743],"genre_scores_gemma":[0.9971914,0.00008998567,0.0004153267,0.00006648504,0.000006197617,0.00001214982,0.0008075262,0.00003914833,0.001371757],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005047821,"threshold_uncertainty_score":0.01688665,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3109872911","doi":"10.1158/2643-3249.lymphoma20-po-10","title":"Abstract PO-10: Histone 1 deficiency drives lymphoma through disruption of 3D chromatin architecture","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Chromatin; Biology; Missense mutation; Genetics; Mutant; Gene; Histone; Molecular biology; Phenotype","authors":[{"name":"Nevin Yusufova","is_ca":false},{"name":"Matt Teater","is_ca":false},{"name":"Andreas Kloetgen","is_ca":false},{"name":"Alexey A. Soshnev","is_ca":false},{"name":"Adewola Osunade","is_ca":false},{"name":"Christopher R. Chin","is_ca":false},{"name":"Ashley S. Doane","is_ca":false},{"name":"Louis M. Staudt","is_ca":false},{"name":"David W. Scott","is_ca":true},{"name":"Neil L. Kelleher","is_ca":false},{"name":"Aristotelis Tsirigos","is_ca":false},{"name":"Marcin Imieliński","is_ca":false},{"name":"Yael David","is_ca":false},{"name":"David Allis","is_ca":false},{"name":"Ethel Cesarman","is_ca":false},{"name":"Ari Melnick","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01033149410809316,"gpt":0.2566450905430812,"spread":0.2463135964349881,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395891,0.0002994921,0.0002007085,0.0003309983,0.000181764,0.0004013877,0.0003206096,0.0003474665,0.004478446],"category_scores_gemma":[0.0000921052,0.0002083049,0.0001843265,0.0001522493,0.000383636,0.0001331687,0.0003261897,0.0007328486,0.001051349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004971597,"about_ca_system_score_gemma":0.0001915122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008914495,"about_ca_topic_score_gemma":0.00154727,"domain_scores_codex":[0.9997556,0.00003597661,0.00002246537,0.00005925275,0.00007103959,0.00005573462],"domain_scores_gemma":[0.9997618,0.00003744803,0.00006959129,0.00002046331,0.00001107893,0.00009967693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004960907,0.00002539146,0.0002050712,0.0000119093,0.000002689468,0.00005419743,0.000007561337,0.00002806173,0.9991145,0.00006268644,0.00003931705,0.000398933],"study_design_scores_gemma":[0.00002793783,0.0002092841,0.009362692,0.00000807081,0.00001291949,0.0006877432,0.00005672681,0.001555301,0.9853851,0.00006442941,0.002625223,0.00000456789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950712,0.0003269767,0.00181694,0.000115839,0.00002424543,0.00002319883,0.0008565202,0.0001946085,0.001570537],"genre_scores_gemma":[0.9939686,0.0001395252,0.0009247211,0.00006722526,0.000005574097,0.00002332175,0.0004824777,0.00006806052,0.004320559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004478446,"threshold_uncertainty_score":0.01498193,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4294771021","doi":"10.1158/2643-3249.lymphoma22-a12","title":"Abstract A12: Pervasive hypermutation of super-enhancer regions dysregulates oncogene expression in diffuse large B-cell lymphoma","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Simon Fraser University","funders":"","keywords":"Biology; Diffuse large B-cell lymphoma; Somatic hypermutation; Enhancer; Genetics; Gene; Cancer research; Germinal center; B cell; Gene expression","authors":[{"name":"Élodie Bal","is_ca":false},{"name":"Rahul Kumar","is_ca":false},{"name":"Mohammad Hadigol","is_ca":false},{"name":"Antony B. Holmes","is_ca":false},{"name":"Laura K. Hilton","is_ca":false},{"name":"Jui Wan Loh","is_ca":false},{"name":"Kostiantyn Dreval","is_ca":true},{"name":"Jasper Wong","is_ca":false},{"name":"Sofija Vlasevska","is_ca":false},{"name":"Clarissa Corinaldesi","is_ca":false},{"name":"Rajesh Kumar Soni Soni","is_ca":false},{"name":"Katia Basso","is_ca":false},{"name":"Ryan D. Morin","is_ca":true},{"name":"Hossein Khiabanian","is_ca":false},{"name":"Laura Pasqualucci","is_ca":false},{"name":"Riccardo Dalla‐Favera","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.012631251303587,"gpt":0.2578647238791112,"spread":0.2452334725755242,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009281513,0.0002047824,0.0001785205,0.0003259345,0.000111777,0.0002981693,0.0001010584,0.0001634524,0.002293569],"category_scores_gemma":[0.0001058709,0.0001129486,0.0001670515,0.0002420634,0.0001710805,0.00007152765,0.0001924426,0.0003471549,0.0005462114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663088,"about_ca_system_score_gemma":0.0001052096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005526461,"about_ca_topic_score_gemma":0.0007559233,"domain_scores_codex":[0.9998341,0.00002189768,0.00001232484,0.00004676555,0.0000522853,0.00003263],"domain_scores_gemma":[0.9998707,0.00002276847,0.00003626516,0.00001677014,0.0000119513,0.00004159797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007317315,0.0000151239,0.001201569,0.00001505872,0.000005279834,0.00005505409,0.000008422889,0.00002598716,0.9976903,0.00002337769,0.00003246751,0.0008542266],"study_design_scores_gemma":[0.00003738936,0.0005651159,0.139199,0.0000107113,0.00005252924,0.002029181,0.0001289787,0.001639083,0.8515158,0.0001027152,0.004709962,0.000009668532],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9969679,0.0005244045,0.001245034,0.00002938454,0.000009223956,0.000009817408,0.0005053343,0.0001033087,0.0006055834],"genre_scores_gemma":[0.997983,0.0001451099,0.0003897462,0.00002400242,0.000003086976,0.00001076181,0.0005326433,0.00002251786,0.0008891429],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002293569,"threshold_uncertainty_score":0.007672727,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4392384143","doi":"10.1158/2643-3249.bcdsymp24-p02","title":"Abstract P02: Uncovering Tailored Therapies for Acute Myeloid Leukemia in Children with Down Syndrome","year":2024,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"","keywords":"Myeloid leukemia; Medicine; Down syndrome; Myeloid; Intensive care medicine; Immunology; Psychiatry","authors":[{"name":"Billy Ta","is_ca":true},{"name":"Emma Rose Cheetham","is_ca":true},{"name":"Sophie Cardin","is_ca":true},{"name":"Verena Gress","is_ca":true},{"name":"Anne-Cécile Soufflet","is_ca":true},{"name":"Nehme Hachem","is_ca":true},{"name":"Mélanie Bilodeau","is_ca":true},{"name":"Sonia Cellot","is_ca":true},{"name":"Carolina Marmolejo","is_ca":true},{"name":"Louise Laramée","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01149696719486758,"gpt":0.2869133705003545,"spread":0.2754164033054869,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282774,0.0002822848,0.0002794005,0.0002234236,0.0001162125,0.0004033372,0.0002627331,0.0003595032,0.001505396],"category_scores_gemma":[0.000212697,0.00008350742,0.0002304803,0.0001536617,0.0001673617,0.0002124619,0.0003822463,0.0005810024,0.0003437251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002641613,"about_ca_system_score_gemma":0.0003892328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003482458,"about_ca_topic_score_gemma":0.000589923,"domain_scores_codex":[0.9999318,0.0000139748,0.00000536276,0.00001481296,0.00001681391,0.00001722314],"domain_scores_gemma":[0.9999349,0.00001416454,0.00001349912,0.000006401434,0.000008089578,0.00002292457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002316271,0.0007949635,0.01887258,0.0006099325,0.0001188146,0.001980178,0.0001695674,0.002368443,0.7824803,0.00258544,0.004713225,0.1829903],"study_design_scores_gemma":[0.001567709,0.02413555,0.08326488,0.0002500086,0.0006409915,0.01309419,0.0004876067,0.01220781,0.7576949,0.00214833,0.1044583,0.0000495961],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9760855,0.008226015,0.008343624,0.001447132,0.0001129803,0.0002752872,0.001222813,0.0001960769,0.004090613],"genre_scores_gemma":[0.9780052,0.006762243,0.01150916,0.0003858535,0.00005525491,0.0002090388,0.001088632,0.00002574635,0.001958749],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001505396,"threshold_uncertainty_score":0.005036056,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3109625190","doi":"10.1158/2643-3249.lymphoma20-po-40","title":"Abstract PO-40: FOXO1 mutations mimic positive selection signals to promote germinal center B-cell expansion and lymphomagenesis","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Germinal center; FOXO1; B cell; Biology; Cancer research; Cancer; PI3K/AKT/mTOR pathway; Lymphoma; Transcription factor; Mutant; Gene; Genetics; Signal transduction; Immunology; Antibody","authors":[{"name":"Mark P. Roberto","is_ca":false},{"name":"Gabriele Varano","is_ca":false},{"name":"Rosa Viñas-Castells","is_ca":false},{"name":"Antony B. Holmes","is_ca":false},{"name":"Rahul Kumar","is_ca":false},{"name":"Pedro Farinha","is_ca":true},{"name":"David W. Scott","is_ca":true},{"name":"David Dominguez-Sola","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.010457849226038,"gpt":0.2415434336151686,"spread":0.2310855843891306,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008963813,0.0002631289,0.0001441628,0.0003082475,0.0001415662,0.0002290682,0.0002071437,0.0002667656,0.005310147],"category_scores_gemma":[0.00006836886,0.0001149395,0.0002119747,0.0001342701,0.0002973554,0.0001618877,0.0003036538,0.0004382122,0.000832123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998881,"about_ca_system_score_gemma":0.0001382699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004191691,"about_ca_topic_score_gemma":0.0007132324,"domain_scores_codex":[0.9998798,0.00001277054,0.000008938411,0.0000243465,0.00004011963,0.00003387668],"domain_scores_gemma":[0.9999241,0.000006964206,0.00001987853,0.000009439299,0.000004470594,0.00003511486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009631071,0.00002783208,0.0001832676,0.00001384445,0.00000250129,0.00006431831,0.000007596005,0.00003503021,0.9982216,0.0001506888,0.0001270092,0.001070081],"study_design_scores_gemma":[0.00004683334,0.0003932554,0.004287259,0.000006702513,0.00001169861,0.0006305562,0.00003047094,0.0004613215,0.9873989,0.0001281097,0.006599319,0.000005609845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926138,0.0004965109,0.001730057,0.0002122932,0.00008715552,0.00002916662,0.0005311353,0.0002884991,0.004011352],"genre_scores_gemma":[0.9896365,0.0003564412,0.001417807,0.00007423027,0.0000153385,0.0000315904,0.0004783659,0.00005744018,0.007932311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005310147,"threshold_uncertainty_score":0.01776421,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3110516422","doi":"10.1158/2643-3249.lymphoma20-po-42","title":"Abstract PO-42: TBL1XR1 mutations drive extranodal lymphomagenesis by inducing a protumorigenic memory B-cell fate","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency; University of Toronto","funders":"","keywords":"Germinal center; BCL6; Biology; Transcription factor; Cancer research; Phenotype; Cell fate determination; Lymphoma; Reprogramming; B cell; Immune system; Cell; Gene; Immunology; Genetics; Antibody","authors":[{"name":"Leandro Venturutti","is_ca":false},{"name":"Matt Teater","is_ca":false},{"name":"Andrew Zhai","is_ca":true},{"name":"Amy Chadburn","is_ca":false},{"name":"Leena Babiker","is_ca":false},{"name":"Daleum Kim","is_ca":false},{"name":"Louis M. Staudt","is_ca":false},{"name":"Michael R. Green","is_ca":false},{"name":"Pedro Farinha","is_ca":true},{"name":"Andrew P. Weng","is_ca":true},{"name":"Christian Steidl","is_ca":true},{"name":"Ryan D. Morin","is_ca":true},{"name":"David W. Scott","is_ca":true},{"name":"Gil Privé","is_ca":true},{"name":"Ari Melnick","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02507749552767352,"gpt":0.2904823327413624,"spread":0.2654048372136889,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009780863,0.0003064054,0.000173228,0.0002397717,0.0001739822,0.0004047513,0.0002317454,0.0003271221,0.007924083],"category_scores_gemma":[0.00007302788,0.0001613534,0.0001744227,0.0001204045,0.0003017566,0.0001643261,0.0003059437,0.0006265189,0.001759037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002195339,"about_ca_system_score_gemma":0.000167937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004890542,"about_ca_topic_score_gemma":0.0006829394,"domain_scores_codex":[0.9998491,0.00002176476,0.00001638603,0.0000381377,0.0000451892,0.00002954446],"domain_scores_gemma":[0.9999146,0.0000115862,0.00002448718,0.00001304059,0.000006489101,0.00002988504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005408533,0.00001489814,0.0001982788,0.00002142535,0.000002661754,0.000129865,0.00001296394,0.00004298456,0.9981276,0.0001805311,0.00014443,0.0010703],"study_design_scores_gemma":[0.00003018576,0.0002295193,0.005045376,0.000007377653,0.00001182784,0.001309755,0.0000571523,0.000566643,0.9848156,0.0001194326,0.007801617,0.000005448164],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862559,0.0008482364,0.003701332,0.0003396197,0.0001201113,0.00004131181,0.0009626464,0.0006136912,0.00711698],"genre_scores_gemma":[0.9794849,0.0005256308,0.001795058,0.0001070406,0.00002034981,0.00003117556,0.0007419072,0.0001081855,0.01718585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007924083,"threshold_uncertainty_score":0.02650869,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3109158687","doi":"10.1158/2643-3249.lymphoma20-po-04","title":"Abstract PO-04: Noncoding mutations in mantle cell lymphoma disrupt regulation of HNRNPH1 by alternative splicing","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Simon Fraser University","funders":"","keywords":"Minigene; RNA splicing; Biology; Exonic splicing enhancer; Exon; Intron; Alternative splicing; Genetics; Exon skipping; Splicing factor; Silent mutation; Nonsense-mediated decay; Mutation; Cancer research; Molecular biology; RNA; Gene; Missense mutation","authors":[{"name":"Krysta M. Coyle","is_ca":true},{"name":"Quratulain Qureshi","is_ca":true},{"name":"Prasath Pararajalingam","is_ca":true},{"name":"Nicole Thomas","is_ca":true},{"name":"Timothy E. Audas","is_ca":true},{"name":"Ryan D. Morin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01310041543215035,"gpt":0.2738839860172324,"spread":0.260783570585082,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192044,0.0002654711,0.0001625864,0.0001802152,0.0001139731,0.0002260687,0.0001871503,0.0002840298,0.001580735],"category_scores_gemma":[0.0001848843,0.0001018206,0.0002686649,0.0001378883,0.0002513375,0.000101908,0.000178149,0.0003707051,0.0004317842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017249,"about_ca_system_score_gemma":0.0001187433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003893157,"about_ca_topic_score_gemma":0.0004619807,"domain_scores_codex":[0.9998763,0.00002193535,0.00001351964,0.00003619053,0.00003413083,0.00001808782],"domain_scores_gemma":[0.9998264,0.00005479076,0.00005513572,0.00001833114,0.000009248852,0.00003610675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007245437,0.0000247896,0.0007762393,0.00001811059,0.000006876245,0.0002357391,0.00001087457,0.00007129067,0.9978605,0.00005938624,0.00003858823,0.000825181],"study_design_scores_gemma":[0.0000224133,0.0002987728,0.01482897,0.000005438409,0.00002597366,0.002032093,0.00003370391,0.002675362,0.9784037,0.0000852884,0.001581479,0.000006814634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970716,0.0002134279,0.001826032,0.00004467855,0.0000148468,0.00001331539,0.0003511627,0.00006414461,0.0004007379],"genre_scores_gemma":[0.9976399,0.00007013336,0.001316487,0.00004549651,0.000004101971,0.00001068785,0.0003693333,0.00002601685,0.0005179415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580735,"threshold_uncertainty_score":0.005288124,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4414228279","doi":"10.1158/2643-3230.bcd-25-0280","title":"Perspectives on Newly Diagnosed Myeloma Treatment and Emerging Challenges","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Multiple myeloma; Immunotherapy; MEDLINE; Clinical Practice; Daratumumab; Cancer","authors":[{"name":"Cyrille Touzeau","is_ca":true},{"name":"Philippe Moreau","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02618619994958432,"gpt":0.329213792396261,"spread":0.3030275924466767,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01703103,0.0008841062,0.002567416,0.001435942,0.003288036,0.006689957,0.003486939,0.01295801,0.009239877],"category_scores_gemma":[0.04282795,0.0005153013,0.002246041,0.001223522,0.007175543,0.01358899,0.004278676,0.02744851,0.001636343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008190652,"about_ca_system_score_gemma":0.01395202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008758418,"about_ca_topic_score_gemma":0.01817528,"domain_scores_codex":[0.9905787,0.004455585,0.001225904,0.00114254,0.001825122,0.0007721273],"domain_scores_gemma":[0.9541058,0.03298562,0.001823047,0.0005512122,0.006743527,0.003790866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001576701,0.00006999791,0.0005620957,0.002646195,0.0001176674,0.001139243,0.001007531,0.0007325676,0.00022185,0.07492752,0.7951602,0.1232574],"study_design_scores_gemma":[0.00004359355,0.00006116781,0.0004048492,0.003970905,0.00006711687,0.001138947,0.00120156,0.0002335019,0.00008504734,0.04163746,0.9510919,0.00006382589],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0002022994,0.1734383,0.0005824908,0.7996494,0.0237217,0.000006569293,0.00006181403,0.00002405557,0.00231355],"genre_scores_gemma":[0.009772241,0.302082,0.001072602,0.5341517,0.1499573,0.00004672274,0.0001380014,0.00006020761,0.002719294],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01703103,"threshold_uncertainty_score":0.09006977,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4416198715","doi":"10.1158/2643-3230.bcd-25-0408","title":"The Global State of Blood Cancers: An Ongoing Challenge","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Global Cancer Incidence and Screening","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network","funders":"","keywords":"State (computer science); Cancer; Field (mathematics); Toll; Cancer treatment","authors":[{"name":"Lillian L. Siu","is_ca":true},{"name":"Peter J. Allen","is_ca":false},{"name":"Kenneth C. Anderson","is_ca":false},{"name":"Michael A. Carducci","is_ca":false},{"name":"Andrew E. Chapman","is_ca":false},{"name":"Steven J. Chmura","is_ca":false},{"name":"Sophia George","is_ca":false},{"name":"Lucy A. Godley","is_ca":false},{"name":"Ana P. Gomes","is_ca":false},{"name":"Carmen Guerra","is_ca":false},{"name":"Trey Ideker","is_ca":false},{"name":"Meredith S. Irwin","is_ca":false},{"name":"Marcela V. Maus","is_ca":false},{"name":"Sandra S. McAllister","is_ca":false},{"name":"Josefina Gómez Mendoza","is_ca":false},{"name":"John M. Salsman","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03640625996574852,"gpt":0.345158677566221,"spread":0.3087524176004725,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01247621,0.0009537484,0.002034789,0.002464666,0.00389771,0.01209447,0.002181718,0.008971712,0.02037797],"category_scores_gemma":[0.01643178,0.0006008155,0.001176586,0.003952748,0.006647067,0.02057319,0.007583221,0.01350518,0.005356885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005777137,"about_ca_system_score_gemma":0.01677762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01032794,"about_ca_topic_score_gemma":0.01592682,"domain_scores_codex":[0.9957871,0.001463634,0.0002881913,0.0004154285,0.001210956,0.0008347359],"domain_scores_gemma":[0.9853174,0.005267792,0.0009457822,0.0007943168,0.003346148,0.004328517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008513621,0.00007408475,0.002277637,0.001070681,0.0000582121,0.0001585084,0.001060848,0.0002824728,0.0003138448,0.06734136,0.7213356,0.2059416],"study_design_scores_gemma":[0.00001759376,0.00007444338,0.004385734,0.001941927,0.00004558833,0.0002638515,0.005498209,0.0002020958,0.0001552324,0.08182655,0.9055229,0.00006583767],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.001007737,0.09809452,0.0007007625,0.880389,0.01064877,0.0000102829,0.0007015388,0.00009975751,0.008347494],"genre_scores_gemma":[0.07413263,0.4580672,0.005890928,0.3936529,0.05342454,0.0001879333,0.002309185,0.000262563,0.0120721],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02037797,"threshold_uncertainty_score":0.06817108,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3106693055","doi":"10.1158/2643-3249.lymphoma20-ia08","title":"Abstract IA08: The role of gene expression in the classification of aggressive B-cell lymphoma","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Lymphoma; Gene expression profiling; B cell; Immunophenotyping; Computational biology; Follicular lymphoma; Cancer research; Oncology; Biology; Medicine; Gene; Internal medicine; Immunology; Gene expression; Genetics; Antigen; Antibody","authors":[{"name":"David W. Scott","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01838753245647009,"gpt":0.2569584069591793,"spread":0.2385708745027092,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002630702,0.0004917404,0.0004979876,0.00293958,0.0003867768,0.002155543,0.0007107317,0.0005285557,0.003287947],"category_scores_gemma":[0.00606127,0.0001116796,0.0004105901,0.00253678,0.00072675,0.0007082172,0.0009376406,0.001060169,0.002170158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007608203,"about_ca_system_score_gemma":0.0004798234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001513156,"about_ca_topic_score_gemma":0.0006922992,"domain_scores_codex":[0.9990649,0.0003276835,0.0001231435,0.0001673321,0.0002008709,0.0001161169],"domain_scores_gemma":[0.9974232,0.0007815025,0.0005047364,0.0001651888,0.0008245382,0.0003008646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001349881,0.00009821813,0.7150315,0.0004560506,0.000247501,0.0003820586,0.00028678,0.001039353,0.02092573,0.002024221,0.03478052,0.2233783],"study_design_scores_gemma":[0.00009225468,0.0004948265,0.9095531,0.0006568283,0.0003498584,0.003723573,0.0009618927,0.01073233,0.005110242,0.006351438,0.06189281,0.00008089137],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8761982,0.05046776,0.01403507,0.01008172,0.002790758,0.0002330732,0.01264683,0.000917862,0.03262876],"genre_scores_gemma":[0.9773436,0.003967048,0.007535913,0.0009548858,0.001021314,0.0001818687,0.006497333,0.0001432866,0.002354894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003287947,"threshold_uncertainty_score":0.01391262,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4392384615","doi":"10.1158/2643-3249.bcdsymp24-p19","title":"Abstract P19: Mitohormetic Regulation in Multiple Myeloma: Exploiting Mitochondrial Stress Responses for Therapeutic Gain","year":2024,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ontario Institute for Cancer Research; University Health Network","funders":"","keywords":"Multiple myeloma; Stress (linguistics); Medicine; Psychology; Internal medicine; Linguistics","authors":[{"name":"Serges P. Tsofack","is_ca":true},{"name":"Danielle Croucher","is_ca":false},{"name":"Benjamin G. Barwick","is_ca":false},{"name":"Zhihua Li","is_ca":false},{"name":"Ahmed Aman","is_ca":true},{"name":"Benjamin Haibe‐Kains","is_ca":false},{"name":"Suzanne Trudel","is_ca":true},{"name":"Lawrence Boise","is_ca":false},{"name":"Aaron D. Schimmer","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04870299445471482,"gpt":0.3412102441585546,"spread":0.2925072497038397,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892913,0.0003419733,0.0002450985,0.0001967572,0.0001879199,0.0003607198,0.000252526,0.0003833153,0.003628818],"category_scores_gemma":[0.00008227098,0.0000712851,0.0002261524,0.0002061009,0.0002306193,0.0001987705,0.0002125853,0.000671052,0.0008468114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721754,"about_ca_system_score_gemma":0.000235913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002105574,"about_ca_topic_score_gemma":0.0002481813,"domain_scores_codex":[0.9999301,0.000007922655,0.00000672967,0.00001681736,0.00002081029,0.00001762125],"domain_scores_gemma":[0.9999229,0.000007288623,0.0000328195,0.000007021932,0.00001146333,0.00001855084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003945036,0.00006818144,0.0005519572,0.000150791,0.00001309708,0.0001561686,0.000009795106,0.0001122995,0.9893077,0.0003263954,0.0005371505,0.00837201],"study_design_scores_gemma":[0.00007769291,0.001021157,0.006861321,0.00002588663,0.00004386657,0.001017623,0.00002025879,0.00072323,0.973308,0.000222025,0.01667302,0.000005906629],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9452521,0.01725583,0.0201871,0.00240564,0.0004129336,0.0003402451,0.003889212,0.001012295,0.009244769],"genre_scores_gemma":[0.9766352,0.005653069,0.006581919,0.0003865172,0.0001267133,0.00009422719,0.001960533,0.0000786173,0.008483211],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003628818,"threshold_uncertainty_score":0.01213962,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4367603663","doi":"10.1158/2643-3249.aml23-a16","title":"Abstract A16: Multi-omic analyses in genetically engineered mice reveal distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; IDH2; Haematopoiesis; Isocitrate dehydrogenase; Epigenetics; Progenitor cell; Myeloid; DNA methylation; Myeloid leukemia; Stem cell; Cancer research; IDH1; Genetics; Mutation; Gene; Gene expression; Enzyme; Biochemistry","authors":[{"name":"Jérôme Fortin","is_ca":true},{"name":"Ming-Feng Chiang","is_ca":true},{"name":"Cem Meydan","is_ca":false},{"name":"Jonathan Foox","is_ca":false},{"name":"Parameswaran Ramachandran","is_ca":true},{"name":"Julie Leca","is_ca":true},{"name":"François Lemonnier","is_ca":false},{"name":"Wanda Y. Li","is_ca":false},{"name":"Miki S. Gams","is_ca":true},{"name":"Takashi Sakamoto","is_ca":false},{"name":"Mandy Chu","is_ca":true},{"name":"Chantal Tobin","is_ca":true},{"name":"Eric Laugesen","is_ca":true},{"name":"Troy M. Robinson","is_ca":false},{"name":"Annick You-Ten","is_ca":true},{"name":"Daniel Butler","is_ca":false},{"name":"Thorsten Berger","is_ca":true},{"name":"Mark D. Minden","is_ca":true},{"name":"Ross L. Levine","is_ca":false},{"name":"Cynthia J. Guidos","is_ca":true},{"name":"Ari Melnick","is_ca":false},{"name":"Christopher E. Mason","is_ca":false},{"name":"Tak W. Mak","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02629545926025301,"gpt":0.3194442679006793,"spread":0.2931488086404263,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002684058,0.0008029799,0.0003760112,0.001505535,0.0003047173,0.0005746211,0.0004585425,0.0008828907,0.004995871],"category_scores_gemma":[0.0001322899,0.0003184868,0.000683303,0.0003661696,0.0006942906,0.0002458388,0.0005763991,0.001575731,0.001134179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004310314,"about_ca_system_score_gemma":0.0002167876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005797474,"about_ca_topic_score_gemma":0.0009180348,"domain_scores_codex":[0.9994186,0.0000496889,0.00006953086,0.0001893808,0.0001677633,0.00010503],"domain_scores_gemma":[0.9995314,0.00006699837,0.0001777924,0.00003939206,0.00002438383,0.0001599954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000971672,0.00003183671,0.0001427459,0.00001734025,0.000008070318,0.0001035687,0.0000138842,0.00004094797,0.9989041,0.0001351788,0.00003169841,0.000473302],"study_design_scores_gemma":[0.0000361819,0.0002540696,0.007038185,0.00001352276,0.00003668869,0.000817234,0.00005727198,0.0008079842,0.9883829,0.0001179418,0.00242692,0.00001121889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794362,0.0007825484,0.009954773,0.0002484489,0.0001135323,0.0001032275,0.006431021,0.0004367367,0.002493548],"genre_scores_gemma":[0.9720651,0.0005998255,0.006882187,0.0002536389,0.0000307541,0.0002023351,0.004689219,0.0005296097,0.01474722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004995871,"threshold_uncertainty_score":0.0167129,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4392366857","doi":"10.1158/2643-3249.bcdsymp24-p11","title":"Abstract P11: ARID1A mutations shape memory B-cell dynamics and confer sensitivity to SWI/SNF remodeling complex inhibition in lymphoma","year":2024,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Terry Fox Research Institute; University of British Columbia","funders":"","keywords":"ARID1A; SWI/SNF; Chromatin remodeling; Cancer research; Dynamics (music); Biology; Genetics; Cell biology; Mutation; Chemistry; Transcription factor; Gene; Physics","authors":[{"name":"Darko Barišić","is_ca":false},{"name":"Christopher R. Chin","is_ca":false},{"name":"Cem Meydan","is_ca":false},{"name":"Matt Teater","is_ca":false},{"name":"Ioanna Tsialta","is_ca":false},{"name":"Coraline Mlynarczyk","is_ca":false},{"name":"Christian Steidl","is_ca":false},{"name":"David W. Scott","is_ca":true},{"name":"Andrew P. Weng","is_ca":true},{"name":"Michael R. Green","is_ca":false},{"name":"Ari Melnick","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01354354032674164,"gpt":0.2643173962480908,"spread":0.2507738559213492,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256555,0.0002554072,0.0002250573,0.0002894924,0.0001205589,0.0002888567,0.0002156044,0.0003127184,0.00255123],"category_scores_gemma":[0.0001440534,0.0001474122,0.0002224921,0.0001248074,0.0002486325,0.0001460927,0.0002193136,0.0005453296,0.0005918107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002641172,"about_ca_system_score_gemma":0.0000892921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004380304,"about_ca_topic_score_gemma":0.0004200463,"domain_scores_codex":[0.9998409,0.00003130336,0.00002044045,0.00003284505,0.0000321361,0.00004237191],"domain_scores_gemma":[0.9997942,0.0000430175,0.00005592569,0.00001943134,0.00001189281,0.00007560795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000112642,0.00004039744,0.0002385731,0.000007173843,0.000003430021,0.00003997945,0.000006410397,0.00004744432,0.9990401,0.00003239321,0.00002657254,0.0004048837],"study_design_scores_gemma":[0.00003435078,0.0005444994,0.007522258,0.00000362069,0.00001396315,0.000390449,0.00003535699,0.00118084,0.9891861,0.00004214224,0.001041311,0.000005065715],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998068,0.0002869543,0.0006740396,0.00003668337,0.00001309707,0.00001243687,0.0003064582,0.00006377097,0.0005385284],"genre_scores_gemma":[0.9983707,0.00009911945,0.0003100845,0.00002519259,0.000004828308,0.00002052386,0.0002121094,0.00002265877,0.0009346901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00255123,"threshold_uncertainty_score":0.008534729,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3110051212","doi":"10.1158/2643-3249.lymphoma20-ia42","title":"Abstract IA42: Detecting and quantifying mutations associated with treatment resistance in aggressive lymphomas using ctDNA","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; Spinal Cord Injury BC; Queen's University; McGill University; Simon Fraser University","funders":"","keywords":"Oncology; Exome sequencing; Exome; Medicine; Precision medicine; Internal medicine; Diffuse large B-cell lymphoma; Lymphoma; Population; Digital polymerase chain reaction; Rituximab; Bioinformatics; Biology; Mutation; Pathology; Genetics; Gene","authors":[{"name":"Nicole Thomas","is_ca":true},{"name":"Laura K. Hilton","is_ca":true},{"name":"Neil R. Michaud","is_ca":false},{"name":"Kevin Bushell","is_ca":true},{"name":"Ryan N. Rys","is_ca":true},{"name":"Michael D. Jain","is_ca":false},{"name":"Lois E. Shepherd","is_ca":true},{"name":"Marco A. Marra","is_ca":true},{"name":"John Kuruvilla","is_ca":true},{"name":"Michael Crump","is_ca":true},{"name":"Koren K. Mann","is_ca":true},{"name":"Sarit Assouline","is_ca":true},{"name":"Christian Steidl","is_ca":true},{"name":"Mark S. Cragg","is_ca":false},{"name":"David W. Scott","is_ca":true},{"name":"Nathalie A. Johnson","is_ca":true},{"name":"Ryan D. Morin","is_ca":true},{"name":"Christopher Rushton","is_ca":true},{"name":"Sarah E. Arthur","is_ca":true},{"name":"Miguel Alcaide","is_ca":true},{"name":"Matthew C. Cheung","is_ca":true},{"name":"Aixiang Jiang","is_ca":true},{"name":"Krysta M. Coyle","is_ca":true},{"name":"Kirstie L.S. Cleary","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03169157068812597,"gpt":0.2752715269306022,"spread":0.2435799562424762,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001569236,0.0006156526,0.0004120815,0.003612601,0.0002606674,0.00185963,0.0004446004,0.0008931558,0.002622741],"category_scores_gemma":[0.003317296,0.0003064987,0.0003875286,0.002124873,0.0002802564,0.0002788087,0.0004801231,0.0005845825,0.0008240588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429035,"about_ca_system_score_gemma":0.0002258972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028903,"about_ca_topic_score_gemma":0.001583689,"domain_scores_codex":[0.9988781,0.0002764299,0.00008511836,0.0003630063,0.0003422142,0.00005511043],"domain_scores_gemma":[0.9986109,0.0003887179,0.0004331971,0.0001545688,0.000299963,0.0001125954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001653587,0.0002088387,0.6120046,0.0005913101,0.001055071,0.0003276951,0.0002192634,0.003290999,0.2955704,0.0003202765,0.00269247,0.08206546],"study_design_scores_gemma":[0.0001425106,0.001245401,0.8266745,0.0002681561,0.000786148,0.004275171,0.0002765957,0.01775172,0.1330671,0.0007488917,0.0146671,0.00009664147],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495082,0.01302615,0.0155275,0.0004320964,0.0001170398,0.0002881529,0.01612762,0.0008031452,0.004170054],"genre_scores_gemma":[0.9660532,0.00183602,0.01837053,0.0005610641,0.00008859549,0.000266323,0.01014792,0.0001068348,0.002569484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003612601,"threshold_uncertainty_score":0.008773983,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}