{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":24,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":24,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"773b5e882fbd","filters":{"venue":"Cancer & Metabolism"}},"results":[{"id":"W2143681046","doi":"10.1186/2049-3002-2-12","title":"Metformin directly acts on mitochondria to alter cellular bioenergetics","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":431,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Jewish General Hospital; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Terry Fox Foundation; McGill University","keywords":"Metformin; Mitochondrion; Bioenergetics; Citric acid cycle; Glycolysis; Cellular respiration; Pharmacology; Biology; Respiration; Chemistry; Biochemistry; Cell biology; Metabolism; Endocrinology; Diabetes mellitus","authors":[{"name":"Sylvia Andrzejewski","is_ca":true},{"name":"Simon‐Pierre Gravel","is_ca":true},{"name":"Michaël Pollak","is_ca":true},{"name":"Julie St‐Pierre","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009116638104370257,"gpt":0.2572476271576801,"spread":0.2481309890533099,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002995468,0.0004095999,0.0004947569,0.0001254143,0.0001149491,0.0000614186,0.0004788888,0.0002310964,0.0002398211],"category_scores_gemma":[0.0001536856,0.0003614768,0.000225648,0.0002479225,0.00007492159,0.000009719025,0.0001344228,0.0001645226,0.0001437618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002997021,"about_ca_system_score_gemma":0.0001124953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005102188,"about_ca_topic_score_gemma":0.00005828519,"domain_scores_codex":[0.9977185,0.0001412408,0.0003508473,0.0007711969,0.0003418161,0.0006764099],"domain_scores_gemma":[0.9983879,0.00001960295,0.0001290017,0.0008902978,0.000164453,0.0004087179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000132154,0.000074703,0.00005229034,0.00002906028,0.000135402,0.000001738095,0.0001231557,0.0003005215,0.743071,0.002340817,0.02653872,0.2272004],"study_design_scores_gemma":[0.0003935215,0.00005826714,0.0001408752,0.00001349975,0.00006044701,4.798625e-7,0.000007235996,0.00001960561,0.4756344,0.0001046631,0.5233082,0.0002587631],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7531323,0.2349514,0.001886614,0.0002216358,0.005257492,0.000434391,0.000105521,0.00005447513,0.003956105],"genre_scores_gemma":[0.8945953,0.05876274,0.004090901,0.01939579,0.01409355,0.0008340731,0.0002270259,0.0002814248,0.007719143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4967695,"threshold_uncertainty_score":0.9998837,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2152647938","doi":"10.1186/2049-3002-1-22","title":"PGC-1α supports glutamine metabolism in breast cancer","year":2013,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; William Osler Health System","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; McGill University; U.S. Department of Defense","keywords":"Breast cancer; Glutamine; Metabolism; Computational biology; Computer science; Medicine; Bioinformatics; Biochemistry; Cancer; Chemistry; Internal medicine; Biology; Amino acid","authors":[{"name":"Shawn McGuirk","is_ca":true},{"name":"Simon‐Pierre Gravel","is_ca":true},{"name":"Geneviève Deblois","is_ca":true},{"name":"David Papadopoli","is_ca":true},{"name":"Brandon Faubert","is_ca":true},{"name":"André Wegner","is_ca":false},{"name":"Karsten Hiller","is_ca":false},{"name":"Daina Avizonis","is_ca":true},{"name":"Uri David Akavia","is_ca":true},{"name":"Russell G. Jones","is_ca":true},{"name":"Vincent Giguère","is_ca":true},{"name":"Julie St‐Pierre","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006744889008735303,"gpt":0.2502870337943439,"spread":0.2435421447856086,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003001264,0.0006403287,0.0008903015,0.0002512823,0.0001279581,0.0001092161,0.0006070085,0.0004033959,0.002965753],"category_scores_gemma":[0.00004173961,0.0005978652,0.0003344245,0.0005522948,0.000223483,0.00006061732,0.0002637917,0.000380696,0.0001040235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006861369,"about_ca_system_score_gemma":0.0005615517,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006978141,"about_ca_topic_score_gemma":0.001115867,"domain_scores_codex":[0.9964258,0.0001426751,0.0007125594,0.001116254,0.0004463212,0.001156397],"domain_scores_gemma":[0.9979584,0.00001428806,0.0002696501,0.0009416656,0.0003630926,0.0004528693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002053027,0.0002612587,0.007351391,0.00008521629,0.0003430428,0.000008047907,0.0003842886,0.0002592155,0.7330843,0.0005164565,0.1110678,0.1464337],"study_design_scores_gemma":[0.002047943,0.00001303651,0.2323016,0.00003659841,0.0001644131,0.00004007021,0.00008306736,0.00003742025,0.04483319,0.0001865534,0.7195625,0.0006935587],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.858878,0.1276127,0.00008785964,0.002286571,0.008291075,0.0008838958,0.000570724,0.00006550246,0.001323733],"genre_scores_gemma":[0.9176831,0.05351099,0.0004216632,0.004226844,0.0144042,0.002116545,0.0002002635,0.0001947337,0.007241719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6882511,"threshold_uncertainty_score":0.9996473,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3036780581","doi":"10.1186/s40170-020-00217-6","title":"Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer","year":2020,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"KU Leuven; Prostate Cancer Foundation of Australia; Movember Foundation; Department of Health and Aged Care, Australian Government; Australian Government; Prostate Cancer Foundation","keywords":"Lipidome; GPX4; Lipidomics; Cancer cell; Lipid metabolism; Lipid peroxidation; Polyunsaturated fatty acid; Chemistry; Enzalutamide; Prostate cancer; Biology; Biochemistry; Oxidative stress; Cancer; Androgen receptor; Fatty acid; Glutathione peroxidase; Superoxide dismutase","authors":[{"name":"Kaylyn D. Tousignant","is_ca":false},{"name":"Anja Rockstroh","is_ca":false},{"name":"Berwyck L. J. Poad","is_ca":false},{"name":"Ali Talebi","is_ca":false},{"name":"Reuben S. E. Young","is_ca":false},{"name":"Atefeh Taherian Fard","is_ca":false},{"name":"Rajesh Gupta","is_ca":false},{"name":"Tuo Zang","is_ca":false},{"name":"Chenwei Wang","is_ca":false},{"name":"Melanie Lehman","is_ca":true},{"name":"Johan Swinnen","is_ca":false},{"name":"Stephen J. Blanksby","is_ca":false},{"name":"Colleen C. Nelson","is_ca":false},{"name":"Martin C. Sadowski","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07128792087865814,"gpt":0.3117025410718659,"spread":0.2404146201932078,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002368885,0.0003567825,0.0008461073,0.0001153818,0.00009983522,0.00005296194,0.00009812725,0.000129394,0.0001475602],"category_scores_gemma":[0.00006261397,0.0003028887,0.0001424398,0.0005892563,0.00007900224,0.0001970632,0.0000697197,0.000459041,0.000007284159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000136079,"about_ca_system_score_gemma":0.0003678075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001814365,"about_ca_topic_score_gemma":0.0002669493,"domain_scores_codex":[0.9978443,0.0001048322,0.0004391762,0.0007350667,0.0003615734,0.0005150025],"domain_scores_gemma":[0.9990413,0.00003438412,0.0001295569,0.0002635483,0.0001652045,0.0003660585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001281781,0.0001381366,0.01471173,0.0002315747,0.0002332373,0.00002432629,0.006268107,0.0002266722,0.2686956,0.0001425246,0.0005668532,0.7074794],"study_design_scores_gemma":[0.01911693,0.0005398517,0.5296847,0.001331398,0.0008766226,0.00003671756,0.003406355,0.01723238,0.1862632,0.000149634,0.2394392,0.001923132],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496706,0.02836234,0.00001800764,0.01981119,0.0004376562,0.0009130897,0.00004477316,0.0001018624,0.0006405405],"genre_scores_gemma":[0.9480309,0.04129328,0.0002711567,0.008945955,0.0009164101,0.0003835842,0.000006950187,0.00007319063,0.00007852962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7055563,"threshold_uncertainty_score":0.9999423,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2168445252","doi":"10.1186/2049-3002-1-9","title":"p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production","year":2013,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Azrieli Foundation; Weizmann Institute of Science; Flight Attendant Medical Research Institute","keywords":"Gluconeogenesis; Glycolysis; Pentose phosphate pathway; Transcriptome; Metabolic pathway; Carcinogenesis; Biology; Transcription factor; Biochemistry; Citric acid cycle; Phosphoenolpyruvate carboxykinase; Cell biology; Gene expression; Chemistry; Gene; Metabolism","authors":[{"name":"Ido Goldstein","is_ca":false},{"name":"Keren Yizhak","is_ca":false},{"name":"Shalom Madar","is_ca":false},{"name":"Naomi Goldfinger","is_ca":false},{"name":"Eytan Ruppin","is_ca":false},{"name":"Varda Rotter","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007626107610773075,"gpt":0.2366889287232319,"spread":0.2290628211124588,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002021398,0.0002247542,0.0003079246,0.00004786095,0.000134586,0.00003145581,0.0002085049,0.0001403381,0.00009740306],"category_scores_gemma":[0.00008323053,0.0001527853,0.00009779526,0.0001551572,0.0002432057,0.00002212745,0.0001051524,0.0000902815,0.000006177905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006661448,"about_ca_system_score_gemma":0.0001023511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003645099,"about_ca_topic_score_gemma":0.00005997329,"domain_scores_codex":[0.9986503,0.0001178107,0.0003309847,0.0004510666,0.00018352,0.0002663813],"domain_scores_gemma":[0.9990074,0.00001341018,0.0002236459,0.0004547887,0.0002142289,0.00008651931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002987941,0.00003290326,0.0002764775,0.00004768646,0.0000583251,7.491415e-8,0.0002431002,0.00001960314,0.9343101,0.00003211853,0.0009052989,0.06404437],"study_design_scores_gemma":[0.0003613996,0.00003025402,0.008872882,0.00003506261,0.0001100205,0.000008366985,0.0001003286,0.00001557038,0.9089165,0.0002012868,0.081168,0.0001803518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.785327,0.2120105,0.00004142772,0.0002979736,0.001711193,0.0005103057,0.0000127497,0.00001442402,0.00007446705],"genre_scores_gemma":[0.9506154,0.04555814,0.000287871,0.0001027997,0.001771305,0.0004018393,0.00002111503,0.0000323795,0.001209128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1664523,"threshold_uncertainty_score":0.6230406,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2145558727","doi":"10.1186/2049-3002-1-18","title":"LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer","year":2013,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; McGill University Health Centre; Canadian Institutes of Health Research; University of Texas MD Anderson Cancer Center; McGill University; Cancer Research Institute","keywords":"Regulator; Breast cancer; Master regulator; Cancer; Cancer research; Medicine; Internal medicine; Computational biology; Bioinformatics; Oncology; Biology; Genetics; Gene; Transcription factor","authors":[{"name":"Fanny Dupuy","is_ca":true},{"name":"Takla Griss","is_ca":true},{"name":"Julianna Blagih","is_ca":true},{"name":"Gaëlle Bridon","is_ca":true},{"name":"Daina Avizonis","is_ca":true},{"name":"Zhifeng Dong","is_ca":true},{"name":"Doris R. Siwak","is_ca":false},{"name":"Matthew G. Annis","is_ca":true},{"name":"Gordon B. Mills","is_ca":false},{"name":"William J. Muller","is_ca":true},{"name":"Peter M. Siegel","is_ca":true},{"name":"Russell G. Jones","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01259460192589621,"gpt":0.260335592047793,"spread":0.2477409901218968,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001714557,0.0003719778,0.0009216198,0.0003040611,0.00004558413,0.00003175082,0.0001684045,0.000180729,0.002687727],"category_scores_gemma":[0.000127962,0.0003196099,0.0001201202,0.0007318871,0.00024273,0.0002858964,0.00008670318,0.0003479076,0.00001539115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171508,"about_ca_system_score_gemma":0.0006894845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005772675,"about_ca_topic_score_gemma":0.0002778566,"domain_scores_codex":[0.9974874,0.00009170363,0.0006621236,0.0005766147,0.0005249677,0.0006571488],"domain_scores_gemma":[0.9983591,0.00005901655,0.0003064935,0.0003605,0.0005598268,0.0003550168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001362444,0.0005502602,0.5468831,0.001416024,0.0007073729,0.00002888774,0.009625295,0.00004490769,0.3823203,0.0008219756,0.0152613,0.04097809],"study_design_scores_gemma":[0.003238411,0.00003653466,0.9412754,0.0002364822,0.0002958151,0.00002940856,0.0001270433,0.0003481226,0.04933446,0.0003636155,0.004406224,0.0003085154],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725794,0.02124334,0.000009086508,0.002810104,0.001093719,0.001417237,0.0004609119,0.00005278,0.0003334247],"genre_scores_gemma":[0.9927288,0.002869667,0.000473275,0.002044628,0.0006658264,0.0009116798,0.00002418223,0.00007008421,0.0002118604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3943923,"threshold_uncertainty_score":0.9999256,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2796145897","doi":"10.1186/s40170-018-0178-3","title":"Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner","year":2018,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Alberta Cancer Foundation; University of Calgary","funders":"National Cancer Institute; University of California, San Francisco; National Institutes of Health","keywords":"Phosphocholine; Choline kinase; Isocitrate dehydrogenase; Choline; Glioma; IDH1; Biology; Chemistry; Biochemistry; Phospholipid; Molecular biology; Enzyme; Mutant; Cancer research; Phosphatidylcholine","authors":[{"name":"Pavithra Viswanath","is_ca":false},{"name":"Marina Radoul","is_ca":false},{"name":"José Luis Izquierdo-García","is_ca":false},{"name":"H. Artee Luchman","is_ca":true},{"name":"J. Gregory Cairncross","is_ca":true},{"name":"Russell O. Pieper","is_ca":false},{"name":"Joanna J. Phillips","is_ca":false},{"name":"Sabrina M. Ronen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008420958632325809,"gpt":0.2537725282294991,"spread":0.2453515695971733,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00039674,0.0004680707,0.0006213954,0.0001825281,0.000150136,0.00006607295,0.0003465851,0.0003112496,0.0003009198],"category_scores_gemma":[0.0001003535,0.0004311609,0.0001437048,0.0003879066,0.0003867293,0.00002327891,0.0002452526,0.0002056476,0.00003074675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004527019,"about_ca_system_score_gemma":0.0001909656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105934,"about_ca_topic_score_gemma":0.001334819,"domain_scores_codex":[0.9974289,0.00009674658,0.0004919202,0.0009587682,0.000296368,0.0007273085],"domain_scores_gemma":[0.9986766,0.0000174758,0.0001784278,0.0006876308,0.0001818027,0.0002580829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005218183,0.00009504449,0.0004569632,0.0000321652,0.0001447679,0.00001053668,0.000331249,0.00004044651,0.9678153,0.0002044781,0.001350223,0.02899697],"study_design_scores_gemma":[0.001626605,0.00005322204,0.01044449,0.00004547642,0.0001264977,0.00003329906,0.00005607045,0.00008747206,0.6814415,0.0001590612,0.305458,0.0004682581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9219263,0.0738565,0.00007547037,0.0003885013,0.002622884,0.000385568,0.0001505794,0.00003536354,0.0005588153],"genre_scores_gemma":[0.9746902,0.01801653,0.0002626644,0.0006779305,0.004430009,0.000308927,0.00002748954,0.000087677,0.001498545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3041078,"threshold_uncertainty_score":0.999814,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1992215279","doi":"10.1186/2049-3002-1-1","title":"Why Cancer & Metabolism? Why now?","year":2013,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Carcinogenesis; Cancer; Epigenome; Biology; Cancer cell; Context (archaeology); Cell metabolism; Cancer research; Overnutrition; Bioinformatics; Cell; Genetics; Endocrinology; DNA methylation; Gene; Obesity","authors":[{"name":"Chi V. Dang","is_ca":false},{"name":"Michaël Pollak","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01473566233443486,"gpt":0.2722417089442749,"spread":0.25750604660984,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002545346,0.0007177101,0.0008867375,0.0001862062,0.0002609477,0.0001856028,0.0008187334,0.0004455459,0.00392618],"category_scores_gemma":[0.00008888733,0.0006603397,0.0004986534,0.0004879377,0.0002826119,0.00006014431,0.0003118742,0.0003936335,0.0003292126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005111229,"about_ca_system_score_gemma":0.0004609461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006097055,"about_ca_topic_score_gemma":0.003476134,"domain_scores_codex":[0.996282,0.0001716982,0.0006351885,0.001207324,0.000537716,0.001166033],"domain_scores_gemma":[0.9972203,0.00002103178,0.0003066754,0.001283725,0.0006056921,0.0005626163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006266971,0.00007002806,0.0002279492,0.00003681465,0.000294457,5.406766e-7,0.0001655845,0.0001055106,0.3851405,0.0003008404,0.5885827,0.02501241],"study_design_scores_gemma":[0.00144758,0.0000159753,0.006944448,0.00002921348,0.0003363558,0.000009956215,0.00005474493,0.00001498043,0.06597869,0.0003078214,0.9240647,0.000795544],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.528325,0.4323718,0.002232608,0.007485753,0.02271491,0.001622013,0.0006048529,0.0001952279,0.004447891],"genre_scores_gemma":[0.24625,0.3837602,0.008206922,0.1463459,0.1138665,0.01266579,0.001149241,0.001160331,0.08659505],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.335482,"threshold_uncertainty_score":0.9995848,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2162440897","doi":"10.1186/2049-3002-1-17","title":"Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers","year":2013,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Juravinski Cancer Centre; McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Gene knockdown; Biology; Microarray analysis techniques; Reactive oxygen species; Oncogene; Cancer research; Cell biology; Cell cycle; Gene expression; Cell; Biochemistry; Gene","authors":[{"name":"Meghan L. Verschoor","is_ca":true},{"name":"Chris P. Verschoor","is_ca":true},{"name":"Gurmit Singh","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008650674438996076,"gpt":0.2597511969303292,"spread":0.2511005224913331,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001185369,0.0002397543,0.0003287896,0.00003986326,0.0001122773,0.00006012235,0.0001240571,0.0001662227,0.0001000046],"category_scores_gemma":[0.00001782038,0.0001921316,0.00004505239,0.0001822256,0.0001225904,0.00003120674,0.0001093125,0.00008721819,0.000002101143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007024129,"about_ca_system_score_gemma":0.0002012476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002642409,"about_ca_topic_score_gemma":0.0007407154,"domain_scores_codex":[0.9986652,0.00009292262,0.0002218225,0.0005130146,0.000166747,0.0003402642],"domain_scores_gemma":[0.9992698,0.00000956275,0.0001582085,0.00023742,0.0001687642,0.0001562004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001110255,0.00005354741,0.1211397,0.00003078648,0.0002139778,0.000002493859,0.000293756,0.00008259841,0.8653212,0.0003896069,0.002730166,0.009631159],"study_design_scores_gemma":[0.001448448,0.00003302573,0.7972253,0.00006819949,0.0001054404,0.00001369643,0.0002311132,0.00002472658,0.1945372,0.0001546618,0.005765808,0.0003923784],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646815,0.032535,0.0002545032,0.0003150456,0.0001728295,0.0004707888,0.001172805,0.00001024274,0.0003872513],"genre_scores_gemma":[0.9922259,0.003978773,0.001954202,0.0003837644,0.0004736514,0.0005229632,0.0001181747,0.00002791859,0.0003146906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6760856,"threshold_uncertainty_score":0.7834901,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4225664734","doi":"10.1186/s40170-022-00282-z","title":"Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics","year":2022,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC","keywords":"Hyperinsulinemia; Biology; Immune system; Endocrinology; Transcriptome; Cancer research; Pancreas; Internal medicine; Pancreatic cancer; Insulin; Cancer; Immunology; Medicine; Gene expression; Gene; Genetics; Insulin resistance","authors":[{"name":"Anni Zhang","is_ca":true},{"name":"Ken Chu","is_ca":true},{"name":"Brian F. Daly","is_ca":true},{"name":"Titine J.J. Ruiter","is_ca":true},{"name":"Yan Dou","is_ca":true},{"name":"Jenny C.C. Yang","is_ca":true},{"name":"Twan J. J. de Winter","is_ca":true},{"name":"Justin Chhuor","is_ca":true},{"name":"Su Wang","is_ca":true},{"name":"Stéphane Flibotte","is_ca":true},{"name":"Yiwei Zhao","is_ca":true},{"name":"Xiaoke Hu","is_ca":true},{"name":"Hong Li","is_ca":true},{"name":"Elizabeth J. Rideout","is_ca":true},{"name":"David F. Schaeffer","is_ca":true},{"name":"James D. Johnson","is_ca":true},{"name":"Janel L. Kopp","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02017657588694292,"gpt":0.2768736061048953,"spread":0.2566970302179524,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004039531,0.0002132009,0.0009235924,0.00005877547,0.0002482899,0.000006775848,0.0001693841,0.00005783297,0.0003302057],"category_scores_gemma":[0.00004188301,0.0001449425,0.0001079106,0.0001747006,0.0003533283,0.00002815497,0.0001041215,0.0003955964,0.000003890636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131533,"about_ca_system_score_gemma":0.0003702524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004334508,"about_ca_topic_score_gemma":0.000008239542,"domain_scores_codex":[0.9982399,0.0002485893,0.0004361268,0.0003091725,0.0004292633,0.000336911],"domain_scores_gemma":[0.9991139,0.000302796,0.0001621874,0.0002945695,0.00003649418,0.00009003755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01348462,0.002434651,0.02494498,0.003094101,0.002217056,0.0001241356,0.03755553,0.0001814851,0.8634887,0.002052297,0.001624436,0.04879799],"study_design_scores_gemma":[0.04008007,0.0006131668,0.2544964,0.0004479527,0.003427244,0.00004946355,0.001399903,0.0002367637,0.4494994,0.0001963215,0.2490607,0.0004926678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8857766,0.1104401,0.00005760946,0.001428927,0.0002863622,0.001181141,0.00002251249,0.00001421952,0.000792542],"genre_scores_gemma":[0.9757556,0.01644273,0.001425215,0.001383075,0.0001411093,0.001727356,0.00001025085,0.00003799207,0.003076636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4139893,"threshold_uncertainty_score":0.5910585,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4377093889","doi":"10.1186/s40170-023-00306-2","title":"Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study","year":2023,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland","funders":"National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; American Heart Association; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital","keywords":"Dapagliflozin; Tolerability; Medicine; Observational study; Internal medicine; Chemotherapy; Oncology; Adverse effect; Diabetes mellitus; Type 2 diabetes; Endocrinology","authors":[{"name":"Lauren K. Park","is_ca":false},{"name":"Kian‐Huat Lim","is_ca":false},{"name":"J. L. Volkman","is_ca":false},{"name":"Mina Abdiannia","is_ca":false},{"name":"Hannah Johnston","is_ca":false},{"name":"Zack Nigogosyan","is_ca":false},{"name":"Marilyn J. Siegel","is_ca":false},{"name":"Janet B. McGill","is_ca":false},{"name":"Alexis M. McKee","is_ca":false},{"name":"Maamoun Salam","is_ca":false},{"name":"Rong M. Zhang","is_ca":false},{"name":"Da Ma","is_ca":false},{"name":"Karteek Popuri","is_ca":true},{"name":"Vincent Chow","is_ca":true},{"name":"Mirza Faisal Beg","is_ca":true},{"name":"William G. Hawkins","is_ca":false},{"name":"Linda R. Peterson","is_ca":false},{"name":"Joseph E. Ippolito","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02992456890926547,"gpt":0.3425159202851841,"spread":0.3125913513759186,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008776867,0.0002132087,0.0009067099,0.0001344519,0.000123015,0.00001217829,0.0001121962,0.00007401512,0.00002606009],"category_scores_gemma":[0.00009801247,0.0001286412,0.00004873454,0.0006682621,0.0002393004,0.0001574083,0.00003018767,0.0001953834,4.552249e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120626,"about_ca_system_score_gemma":0.0005717872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001825823,"about_ca_topic_score_gemma":0.0001823645,"domain_scores_codex":[0.9981212,0.0002253272,0.0004073196,0.0003961166,0.0005430155,0.0003070025],"domain_scores_gemma":[0.9985233,0.0004016481,0.0001397445,0.0003149544,0.0005295149,0.00009086855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02001899,0.002204464,0.9714054,0.0004791786,0.0002322284,0.000004324346,0.00177443,0.0000288884,0.0007859424,0.0001201784,0.00001752325,0.002928453],"study_design_scores_gemma":[0.07432171,0.002820692,0.9192126,0.0003893547,0.0003680214,0.000001296312,0.0003403926,0.0002435387,0.001744719,0.0001787248,0.0002453729,0.0001335092],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927344,0.000707078,0.0001722561,0.0003730797,0.00009591373,0.005680973,0.0001874046,0.00002355379,0.00002535991],"genre_scores_gemma":[0.9977781,0.0002075468,0.0003232091,0.00008669343,0.00004473384,0.001362046,0.00009221411,0.0000347835,0.00007071312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05430271,"threshold_uncertainty_score":0.5245837,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3136889170","doi":"10.1186/s40170-021-00247-8","title":"Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes","year":2021,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mutant; Isocitrate dehydrogenase; Citric acid cycle; Biology; IDH1; IDH2; Gene; Biochemistry; Enzyme","authors":[{"name":"Sinthu Pathmanapan","is_ca":true},{"name":"Olga Ilkayeva","is_ca":false},{"name":"John T. Martin","is_ca":false},{"name":"Adrian Kwan Ho Loe","is_ca":true},{"name":"Hongyuan Zhang","is_ca":false},{"name":"Guofang Zhang","is_ca":false},{"name":"Christopher B. Newgard","is_ca":false},{"name":"Jay S. Wunder","is_ca":true},{"name":"Benjamin A. Alman","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01241734580839978,"gpt":0.2725079701757108,"spread":0.2600906243673111,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001196727,0.0003686204,0.000937191,0.00008079457,0.0001543804,0.00006551433,0.00009100362,0.00009407298,0.0006465766],"category_scores_gemma":[0.00007174831,0.0002798171,0.000211874,0.0003557226,0.0001398704,0.000129134,0.0001171424,0.0002410077,0.00004970883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006470858,"about_ca_system_score_gemma":0.0002391236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002961086,"about_ca_topic_score_gemma":0.0001075948,"domain_scores_codex":[0.9980493,0.00005960023,0.0003798331,0.0006520906,0.0003702803,0.0004889241],"domain_scores_gemma":[0.9987349,0.00006468705,0.0001229878,0.0005441968,0.0001465078,0.0003867117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003226901,0.001621667,0.3744705,0.0004876351,0.002301811,0.007195752,0.001288987,0.000004340929,0.5424245,0.005475341,0.001718789,0.06268805],"study_design_scores_gemma":[0.003796292,0.00004873561,0.5952364,0.0001647946,0.001792095,0.0001956116,0.00007544591,0.00006553478,0.2603002,0.0002569345,0.137728,0.0003399696],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8874589,0.1087129,0.00004805665,0.001438505,0.0009303037,0.0003373605,0.0001944916,0.0000534657,0.0008260469],"genre_scores_gemma":[0.9892009,0.006850895,0.0004124127,0.0005820357,0.0004900791,0.0002158673,0.00007773109,0.00006233563,0.002107732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2821243,"threshold_uncertainty_score":0.9999654,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2337676298","doi":"10.1186/s40170-016-0149-5","title":"Molecular characterization of Gleason patterns 3 and 4 prostate cancer using reverse Warburg effect-associated genes","year":2016,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Ontario Institute for Cancer Research; Queen's University","funders":"Prostate Cancer Fight Foundation; Terry Fox Foundation; Prostate Cancer Canada; Ontario Institute for Cancer Research; Movember Foundation","keywords":"Prostate cancer; Biology; Stromal cell; Cancer research; Gene; Gene expression profiling; Cancer; Prostate; Gene expression; Phenotype; Oncology; Genetics; Medicine","authors":[{"name":"Ilinca Georgescu","is_ca":true},{"name":"R. J. Gooding","is_ca":true},{"name":"R. Christopher Doiron","is_ca":true},{"name":"Andrew G. Day","is_ca":true},{"name":"Shamini Selvarajah","is_ca":true},{"name":"Chris Davidson","is_ca":true},{"name":"David M. Berman","is_ca":true},{"name":"Paul C. Park","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008446137722471844,"gpt":0.2502482053853968,"spread":0.2418020676629249,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009313099,0.0001530755,0.000202112,0.00004395024,0.00003532906,0.00001075869,0.00006362669,0.0001163651,0.00003726294],"category_scores_gemma":[0.00001970779,0.0001194567,0.00006221436,0.00007810213,0.000058274,0.00001669287,0.00002610868,0.00003102841,5.53553e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003062011,"about_ca_system_score_gemma":0.00005051656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002508186,"about_ca_topic_score_gemma":0.00003209195,"domain_scores_codex":[0.9991403,0.00009599651,0.0001865772,0.0002768122,0.0001282353,0.0001720345],"domain_scores_gemma":[0.99947,0.000004078701,0.0001719176,0.0001661526,0.0001290875,0.00005875011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007553402,0.00001140232,0.04063178,0.00003918789,0.00007512708,4.672802e-7,0.00005022704,0.00002625334,0.9414128,0.000008453718,0.000009599882,0.01765915],"study_design_scores_gemma":[0.0008669203,0.00003127954,0.1684406,0.00009891293,0.00009078366,7.949332e-7,0.000002890878,0.00005139437,0.8223944,0.000004373087,0.007877679,0.0001399354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936931,0.003753153,0.001346998,0.0001303904,0.0003492095,0.0002767812,0.0004341416,0.00001292616,0.000003343449],"genre_scores_gemma":[0.9958372,0.003615405,0.00003130702,0.00008679567,0.0001137403,0.00004962711,0.000108289,0.00002901119,0.0001286684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1278088,"threshold_uncertainty_score":0.4871301,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4403109171","doi":"10.1186/s40170-024-00357-z","title":"Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles","year":2024,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Vancouver General Hospital; BC Children's Hospital; University of British Columbia; Pancreas Centre (Canada)","funders":"Canadian Cancer Society Research Institute; BC Cancer Foundation; Vancouver Coastal Health Research Institute; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"Organoid; Pancreatic cancer; Cancer; Biology; Cancer research; Internal medicine; Computational biology; Medicine; Cell biology; Genetics","authors":[{"name":"Hassan A. Ali","is_ca":true},{"name":"Joanna M. Karasinska","is_ca":true},{"name":"James T. Topham","is_ca":true},{"name":"Danisha Johal","is_ca":true},{"name":"Steve E. Kalloger","is_ca":true},{"name":"Andrew Metcalfe","is_ca":true},{"name":"Cassia Warren","is_ca":true},{"name":"A. Miyagi","is_ca":true},{"name":"Lan Valerie Tao","is_ca":true},{"name":"Maya Kevorkova","is_ca":true},{"name":"Shawn C. Chafe","is_ca":false},{"name":"Paul C. McDonald","is_ca":false},{"name":"Shoukat Dedhar","is_ca":true},{"name":"Seth J. Parker","is_ca":true},{"name":"Daniel J. Renouf","is_ca":true},{"name":"David F. Schaeffer","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01680793422931625,"gpt":0.2634184537419656,"spread":0.2466105195126493,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003177783,0.0005707631,0.0008623804,0.0002942383,0.0001175059,0.0001828854,0.0005131118,0.000240075,0.000943392],"category_scores_gemma":[0.00005369956,0.0004893401,0.0002828189,0.0008210718,0.0002256211,0.00003552622,0.0001665878,0.0003953989,0.00006598551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005950805,"about_ca_system_score_gemma":0.0007607368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009580823,"about_ca_topic_score_gemma":0.0007697254,"domain_scores_codex":[0.9968486,0.0001581576,0.0005846983,0.00116894,0.0003997215,0.0008398379],"domain_scores_gemma":[0.99879,0.00003075559,0.0001290688,0.0006601646,0.0001466032,0.0002434042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002422959,0.0001431889,0.01020293,0.0003080923,0.0004749315,0.00002621374,0.000861367,0.00004919057,0.8743438,0.004587698,0.02770325,0.081057],"study_design_scores_gemma":[0.0007482868,0.00002573704,0.04898196,0.0001563314,0.0002156699,0.00001498129,0.0001155502,0.00004892085,0.1553523,0.0002241591,0.7935162,0.0005998703],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5572618,0.4359825,0.00008185316,0.0002590236,0.005321653,0.0003776058,0.000207917,0.00006556733,0.0004420897],"genre_scores_gemma":[0.8389123,0.1446291,0.0002246226,0.0005555667,0.009587119,0.001135741,0.00007918805,0.0001348404,0.004741546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.765813,"threshold_uncertainty_score":0.9999699,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4394618759","doi":"10.1186/s40170-024-00341-7","title":"Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma","year":2024,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; Medical School, University of Michigan; National Cancer Institute; National Institutes of Health; Leah's Happy Hearts; Pediatric Brain Tumor Foundation; Ian's Friends Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; Sontag Foundation; Rogel Cancer Center, University of Michigan; Damon Runyon Cancer Research Foundation","keywords":"Hypoxanthine-guanine phosphoribosyltransferase; Hypoxanthine; Purine; Purine metabolism; Biochemistry; Biology; Chemistry; Molecular biology; Mutant; Enzyme; Gene","authors":[{"name":"Erik R. Peterson","is_ca":false},{"name":"Peter Sajjakulnukit","is_ca":false},{"name":"Andrew J. Scott","is_ca":false},{"name":"Caleb Heaslip","is_ca":false},{"name":"Anthony Andren","is_ca":false},{"name":"Kari Wilder-Romans","is_ca":false},{"name":"Weihua Zhou","is_ca":false},{"name":"Sravya Palavalasa","is_ca":false},{"name":"Navyateja Korimerla","is_ca":false},{"name":"Angelica Lin","is_ca":false},{"name":"Alexandra O’Brien","is_ca":false},{"name":"Ayesha U. Kothari","is_ca":false},{"name":"Zitong Zhao","is_ca":false},{"name":"Li Zhang","is_ca":false},{"name":"Meredith A. Morgan","is_ca":false},{"name":"Sriram Venneti","is_ca":false},{"name":"Carl Koschmann","is_ca":false},{"name":"Nada Jabado","is_ca":true},{"name":"Costas A. Lyssiotis","is_ca":false},{"name":"María G. Castro","is_ca":false},{"name":"Daniel Wahl","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01984490041380862,"gpt":0.3047120837147619,"spread":0.2848671833009533,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001079109,0.0003947653,0.0007166861,0.0003656793,0.00005600786,0.00007433563,0.0001002138,0.0001031207,0.001257419],"category_scores_gemma":[0.0000522461,0.0002746362,0.0002333275,0.0007772954,0.00007382229,0.0001201099,0.00003856461,0.0001619785,0.0001106586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004985037,"about_ca_system_score_gemma":0.0002437169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004658967,"about_ca_topic_score_gemma":0.001273236,"domain_scores_codex":[0.9979993,0.00004927556,0.0004406792,0.0006859713,0.0003261083,0.0004987331],"domain_scores_gemma":[0.9990099,0.0001049132,0.00005962332,0.0005237459,0.00006471328,0.0002370825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002733211,0.01848218,0.03036438,0.002848167,0.005034267,0.06051868,0.01044302,0.0000339442,0.5104246,0.02260404,0.04281655,0.293697],"study_design_scores_gemma":[0.008243921,0.0002417402,0.08686918,0.001306222,0.00099073,0.0001003326,0.00005898094,0.0001716319,0.1725061,0.0008476095,0.7282069,0.0004566779],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8322609,0.1590302,0.00000385764,0.00561068,0.0006483091,0.0008634187,0.000542472,0.0001757763,0.0008643725],"genre_scores_gemma":[0.9883391,0.005730894,0.0005923182,0.0002191344,0.0007537459,0.00151686,0.000126727,0.00007985478,0.00264131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6853903,"threshold_uncertainty_score":0.9999706,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4304807359","doi":"10.1186/s40170-022-00294-9","title":"Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls","year":2022,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"George & Fay Yee Centre for Healthcare Innovation; University of Manitoba; CancerCare Manitoba","funders":"Institute of Cancer Research; Canadian Institutes of Health Research; CancerCare Manitoba Foundation","keywords":"Lung cancer; Metabolite; Identification (biology); Cancer; Chemistry; Cancer cell; Biology; Medicine; Biochemistry; Internal medicine","authors":[{"name":"Julian O. Kim","is_ca":true},{"name":"Robert Balshaw","is_ca":true},{"name":"Connel Trevena","is_ca":true},{"name":"Shantanu Banerji","is_ca":true},{"name":"Leigh C. Murphy","is_ca":true},{"name":"David Dawe","is_ca":true},{"name":"Lawrence Tan","is_ca":true},{"name":"Sadeesh Srinathan","is_ca":true},{"name":"Gordon Buduhan","is_ca":true},{"name":"Biniam Kidane","is_ca":true},{"name":"Gefei Qing","is_ca":true},{"name":"Michael Domaratzki","is_ca":true},{"name":"Michel Aliani","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03427075193865343,"gpt":0.297790308161389,"spread":0.2635195562227356,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004249119,0.000277447,0.000783174,0.000199544,0.0001538902,0.00002030884,0.0006353786,0.00009197583,0.00003318833],"category_scores_gemma":[0.0001235532,0.0002790293,0.000204451,0.0002519111,0.0001823586,0.00002783469,0.0007708474,0.0001356256,5.6675e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003168964,"about_ca_system_score_gemma":0.0001973229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002250201,"about_ca_topic_score_gemma":0.001238012,"domain_scores_codex":[0.9979765,0.0001243543,0.0007418183,0.0006249553,0.0002128777,0.0003194413],"domain_scores_gemma":[0.9977168,0.00007095736,0.0009808897,0.0008037327,0.0003480191,0.00007962298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001792081,0.00008112178,0.001180481,0.0003181382,0.0009999381,6.542616e-7,0.0001693956,0.001489771,0.9909326,0.0002189048,0.0001776188,0.002639341],"study_design_scores_gemma":[0.005080186,0.0002147385,0.006882171,0.00001447975,0.001872711,0.000001587631,0.0004435135,0.002903118,0.9618894,0.00002379864,0.02038527,0.0002889699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8988186,0.08074147,0.002002099,0.00006714446,0.00172275,0.0007628022,0.01586338,0.000006617055,0.00001517518],"genre_scores_gemma":[0.9789842,0.01893738,0.0005223366,0.0000265732,0.0003265279,0.0006800123,0.0002294967,0.00004230692,0.0002511978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08016561,"threshold_uncertainty_score":0.9999662,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4387771126","doi":"10.1186/s40170-023-00318-y","title":"Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition","year":2023,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Medical Research Council; James Tudor Foundation; University of Bristol; Diabetes UK; European Research Council; Cancer Research UK; World Cancer Research Fund; McGill University; Bowel and Cancer Research","keywords":"Glutaminase; Colorectal cancer; Aspirin; Cancer; Metabolism; Medicine; Cancer research; Internal medicine; Glutamate receptor","authors":[{"name":"Amy K. Holt","is_ca":false},{"name":"Arafath K. Najumudeen","is_ca":false},{"name":"T J Collard","is_ca":false},{"name":"Hao Li","is_ca":false},{"name":"Laura M. Millett","is_ca":false},{"name":"Ashley J. Hoskin","is_ca":false},{"name":"Danny Legge","is_ca":false},{"name":"E Mortensson","is_ca":false},{"name":"Dustin J. Flanagan","is_ca":false},{"name":"Nicholas Jones","is_ca":false},{"name":"Madhu Kollareddy","is_ca":false},{"name":"Penny Timms","is_ca":false},{"name":"Matthew D. Hitchings","is_ca":false},{"name":"J. Cronin","is_ca":false},{"name":"Owen J. Sansom","is_ca":false},{"name":"Ann C. Williams","is_ca":false},{"name":"Emma E. Vincent","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01226694538470879,"gpt":0.2740718180348985,"spread":0.2618048726501897,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003460044,0.0004566777,0.0005827108,0.0001636148,0.0002248336,0.0001063451,0.0001860882,0.0002661232,0.00009564576],"category_scores_gemma":[0.00007609444,0.0004593577,0.0002065231,0.0006033516,0.0001693953,0.00003032139,0.0003243142,0.0001789605,0.00004395676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004271456,"about_ca_system_score_gemma":0.000268222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001970025,"about_ca_topic_score_gemma":0.00187318,"domain_scores_codex":[0.9972543,0.0001192774,0.0004059769,0.001082027,0.0003337341,0.0008047026],"domain_scores_gemma":[0.9986366,0.00001971489,0.0001561732,0.0004945644,0.0002432904,0.0004496287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002020096,0.00005129971,0.000253649,0.00006715437,0.0001083735,0.00001056763,0.0004835025,0.0001392299,0.8741703,0.0001546322,0.02008903,0.1042702],"study_design_scores_gemma":[0.0009831217,0.00004375433,0.01955388,0.00002724109,0.0001699738,0.00001339928,0.0002074239,0.0000188528,0.4141922,0.00005311883,0.5643092,0.0004278664],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9135693,0.08008643,0.00008044837,0.0005668066,0.003929551,0.0006552239,0.0005044757,0.0001394485,0.0004682555],"genre_scores_gemma":[0.9263391,0.05784865,0.0005463592,0.001978745,0.008317159,0.00115922,0.0002873491,0.0001419679,0.003381394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5442201,"threshold_uncertainty_score":0.9997858,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4410338584","doi":"10.1186/s40170-025-00391-5","title":"Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer","year":2025,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Universitätsklinikum Tübingen","keywords":"Ascites; Identification (biology); Ovarian cancer; Cancer; Medicine; Internal medicine; Biology; Gastroenterology; Ecology","authors":[{"name":"Sisi Deng","is_ca":false},{"name":"Qianlu Yang","is_ca":false},{"name":"Yogesh Singh","is_ca":false},{"name":"Gyuntae Bae","is_ca":false},{"name":"Nicolas Bézière","is_ca":false},{"name":"Lukas F. Mager","is_ca":true},{"name":"Stefan Kommoss","is_ca":false},{"name":"Jannik Sprengel","is_ca":false},{"name":"Christoph Trautwein","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007229767624540611,"gpt":0.2913393584116079,"spread":0.2841095907870673,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946931,0.0001571837,0.0004071085,0.0001805846,0.00003172915,0.0000149056,0.0001007649,0.00005114313,0.00001896043],"category_scores_gemma":[0.0001122434,0.0001358181,0.00008069746,0.0002629255,0.0001855231,0.000007634809,0.0001142269,0.00006515314,7.204726e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001231077,"about_ca_system_score_gemma":0.0001283607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008915506,"about_ca_topic_score_gemma":0.0002000436,"domain_scores_codex":[0.9990824,0.00004824193,0.0003305461,0.0003016641,0.00005824129,0.0001789377],"domain_scores_gemma":[0.9994232,0.00001855648,0.0001829306,0.0001897615,0.0001477116,0.00003781483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007746269,0.00002869191,0.07590991,0.0000625221,0.0001646046,1.910357e-7,0.00005826904,0.00001477135,0.9203131,0.0008536996,0.0001093208,0.002407472],"study_design_scores_gemma":[0.0005326681,0.00002167753,0.5613216,0.00004175476,0.00008826869,0.000002048064,0.00004262853,0.00001837492,0.4368948,0.0002277236,0.0007317039,0.00007679711],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.911641,0.08750653,0.000230025,0.0001347653,0.0001056149,0.0001524515,0.0001545956,0.00000269666,0.00007229745],"genre_scores_gemma":[0.9845553,0.01424518,0.0008637289,0.00003429213,0.00005575631,0.00003929719,0.00001202076,0.000009179633,0.000185236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4854117,"threshold_uncertainty_score":0.5538502,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4412708368","doi":"10.1186/s40170-025-00402-5","title":"Pharmacological inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) imparts selective leukemia cell death","year":2025,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University of Waterloo; Ontario Institute for Cancer Research; University of Guelph","funders":"","keywords":"Myeloid leukemia; In vivo; Haematopoiesis; Cell culture; Cancer research; Pharmacology; Cell growth; Programmed cell death; Myeloid; Leukemia; In vitro; Biology; Chemistry; Stem cell; Immunology; Apoptosis; Cell biology; Biochemistry","authors":[{"name":"Yingying Yang","is_ca":true},{"name":"Ekaterina Parfenova","is_ca":true},{"name":"Nikolina Vrdoljak","is_ca":true},{"name":"Mark D. Minden","is_ca":true},{"name":"Jessica Luc","is_ca":true},{"name":"Andrew C. Doxey","is_ca":true},{"name":"Paul A. Spagnuolo","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01167597164689446,"gpt":0.2847072493633954,"spread":0.2730312777165009,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001912251,0.0003655122,0.0004679863,0.0001642994,0.0001639204,0.00003457072,0.0002248459,0.0003997843,0.0002455566],"category_scores_gemma":[0.00008671526,0.0003349866,0.0001707217,0.0005270351,0.0001343906,0.0000303871,0.0001365511,0.0003295814,0.00001078522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002253694,"about_ca_system_score_gemma":0.0009107754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006211185,"about_ca_topic_score_gemma":0.00001014961,"domain_scores_codex":[0.9979498,0.0002222046,0.0004827112,0.0006693718,0.0002240464,0.0004518783],"domain_scores_gemma":[0.9988759,0.00002315979,0.0002479956,0.0002843097,0.0004196529,0.0001490484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005243961,0.000163631,0.003353337,0.00004547437,0.0002511501,8.154787e-7,0.0000882789,0.0002763947,0.9849686,0.0001178341,0.009347797,0.0008622807],"study_design_scores_gemma":[0.001611525,0.0001159505,0.001654291,0.00003403956,0.0001320877,0.000001749884,0.00004612258,0.00006614856,0.9631359,0.00006907059,0.03282375,0.0003093571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923567,0.00402187,0.000440863,0.0001699182,0.0008648578,0.0006888231,0.0001428663,0.00005536483,0.001258723],"genre_scores_gemma":[0.9952839,0.001539493,0.0004497023,0.0006393821,0.0005598001,0.0005002473,0.00027962,0.00003962396,0.0007082326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02347595,"threshold_uncertainty_score":0.9999102,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2040417994","doi":"10.1186/2049-3002-2-s1-p82","title":"Lung tumors and non-malignant airways from patients with chronic lung inflammatory disease bear distinct genetic and epigenetic disruptions corresponding to metabolic processes involved in senescence and methylation","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Vancouver General Hospital; University Health Network; Princess Margaret Cancer Centre; Occupational Cancer Research Centre","funders":"","keywords":"COPD; Lung; Medicine; Epigenetics; Lung cancer; DNA methylation; Inflammation; Disease; Pulmonary disease; Obstructive lung disease; Bioinformatics; Immunology; Pathology; Internal medicine; Oncology; Gene; Biology; Gene expression","authors":[{"name":"Emily A. Vucic","is_ca":true},{"name":"Kelsie L. Thu","is_ca":true},{"name":"Victor D. Martínez","is_ca":true},{"name":"Chiara Pastrello","is_ca":true},{"name":"John Yee","is_ca":true},{"name":"Igor Jurišica","is_ca":true},{"name":"Stephen Lam","is_ca":true},{"name":"Wan L. Lam","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004996237368249016,"gpt":0.2327628319541761,"spread":0.2277665945859271,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135639,0.0002340161,0.0002576396,0.0001092397,0.0001509528,0.00006760244,0.0001067916,0.00006323298,0.00000706794],"category_scores_gemma":[0.00009183229,0.0002034166,0.00002091644,0.0002221572,0.0001275924,0.00002584817,0.00009816873,0.0000748169,5.70107e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003001903,"about_ca_system_score_gemma":0.0002090465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002058913,"about_ca_topic_score_gemma":0.0008885569,"domain_scores_codex":[0.9986651,0.0000817976,0.0002521562,0.0005893235,0.000145938,0.000265715],"domain_scores_gemma":[0.9991892,0.00002714934,0.0001183591,0.0002889521,0.0001196499,0.0002566745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001758605,0.00003797058,0.9108264,0.0001769087,0.00004495659,0.000001545185,0.0003739472,0.0006774427,0.06899939,0.00004243752,0.00001772154,0.01862539],"study_design_scores_gemma":[0.0008887119,0.0000341446,0.9873943,0.0001454038,0.0001442527,3.31685e-7,0.00003347143,0.002066615,0.007005963,0.00004337644,0.001950865,0.0002925594],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.946286,0.04667908,0.006224418,0.00007158776,0.0000846347,0.0005229171,0.0001176291,0.000009255492,0.000004485299],"genre_scores_gemma":[0.9950755,0.003766349,0.0003729201,0.00007272323,0.0002005243,0.0003702015,0.00008219943,0.00003360352,0.00002603876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07656787,"threshold_uncertainty_score":0.8295088,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2052248798","doi":"10.1186/2049-3002-2-s1-p76","title":"Disruption of the endocannabinoid system is prominent in lung adenocarcinoma and associated with poor patient survival","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Endocannabinoid system; Adenocarcinoma; Lung; Medicine; Computer science; Internal medicine; Bioinformatics; Oncology; Biology; Cancer; Receptor","authors":[{"name":"Kelsie L. Thu","is_ca":true},{"name":"Roland Hubaux","is_ca":true},{"name":"Stephen Lam","is_ca":true},{"name":"Wan L. Lam","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009980889087703927,"gpt":0.2591438497111944,"spread":0.2491629606234904,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003777121,0.0001775772,0.0004909114,0.0001134451,0.00006625176,0.00001975568,0.0001101076,0.0000796429,0.00003497018],"category_scores_gemma":[0.0001000119,0.0001061763,0.00008490666,0.0004136279,0.0001521349,0.000056963,0.00008039296,0.0002449012,7.058165e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351296,"about_ca_system_score_gemma":0.0002492709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113606,"about_ca_topic_score_gemma":0.0002972559,"domain_scores_codex":[0.998209,0.0001879707,0.000330091,0.0003174145,0.0006124527,0.0003430971],"domain_scores_gemma":[0.9990907,0.00001222584,0.000175967,0.0003228878,0.0002559666,0.0001422643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001128223,0.0003641137,0.9228148,0.001888559,0.0003961394,0.00002955945,0.005987815,0.00003916484,0.02827188,0.003396303,0.01404034,0.02164312],"study_design_scores_gemma":[0.002608459,0.0001534899,0.9735051,0.0004814226,0.000186158,0.0000144248,0.0005210076,0.001215812,0.01300349,0.000008542481,0.008163009,0.0001391073],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882722,0.005474563,0.00001107181,0.004508066,0.0003130947,0.0009231564,0.00005456631,0.00001889091,0.0004243334],"genre_scores_gemma":[0.9979672,0.0000834182,0.000007978521,0.0002306672,0.000139377,0.0002669742,0.000006808974,0.00002887347,0.001268679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05069028,"threshold_uncertainty_score":0.4329743,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2084679459","doi":"10.1186/2049-3002-2-s1-p4","title":"Dual mode of action of metformin on mitochondrial metabolism","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Jewish General Hospital; McGill University Health Centre","funders":"","keywords":"Metformin; Bioenergetics; Mitochondrion; Respiration; Pharmacology; Citric acid cycle; Cellular respiration; Chemistry; Biology; Metabolism; Medicine; Endocrinology; Diabetes mellitus; Biochemistry; Anatomy","authors":[{"name":"Sylvia Andrzejewski","is_ca":true},{"name":"Simon‐Pierre Gravel","is_ca":true},{"name":"Julie St‐Pierre","is_ca":true},{"name":"Michaël Pollak","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02923056596506879,"gpt":0.3367431623377685,"spread":0.3075125963726997,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002615702,0.0003491336,0.001400433,0.0003670856,0.00005788102,0.000007930634,0.0001792892,0.0002365369,0.0005205101],"category_scores_gemma":[0.0002620792,0.0002863669,0.0003823809,0.0004355615,0.0001841481,0.0002049936,0.00005230919,0.0003377302,0.00003481648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003276125,"about_ca_system_score_gemma":0.0002231613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005380978,"about_ca_topic_score_gemma":0.00003074052,"domain_scores_codex":[0.9975443,0.000128121,0.0007462763,0.0004472018,0.0007078726,0.0004262605],"domain_scores_gemma":[0.9980817,0.0000990712,0.0004752331,0.0007296038,0.0003546248,0.000259774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001365224,0.0003386072,0.0000837878,0.0002285488,0.0005235355,0.000005480311,0.001079459,0.0001772242,0.7414731,0.04083017,0.002664174,0.2112307],"study_design_scores_gemma":[0.003713356,0.0001213204,0.007467611,0.0001058651,0.001436809,0.00001747612,0.00006609828,0.0001906025,0.6217397,0.0009990874,0.363914,0.0002280263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714701,0.01365802,0.001578308,0.000454491,0.005513509,0.000787522,0.0001702671,0.00009004315,0.006277801],"genre_scores_gemma":[0.9867335,0.002144895,0.003069998,0.000431768,0.00440283,0.00009975184,0.00003102452,0.00007975408,0.003006477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3612498,"threshold_uncertainty_score":0.9999589,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2023762860","doi":"10.1186/2049-3002-2-s1-p18","title":"Altered cancer cell metabolism and cachexia: Calculating the energetic cost of cancer","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Cachexia; Anaerobic glycolysis; Anaerobic exercise; Cancer; Cancer cachexia; Medicine; Glycolysis; Energy metabolism; Metabolism; Cancer research; Cancer cell; Internal medicine; Physiology","authors":[{"name":"Douglas E. Friesen","is_ca":true},{"name":"Vickie E. Baracos","is_ca":true},{"name":"Jack A. Tuszyński","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03404606478944722,"gpt":0.3557896334319486,"spread":0.3217435686425014,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004544724,0.0002712023,0.0007782403,0.00008575901,0.0002239358,0.00002485228,0.0001556154,0.0001229772,0.0007462583],"category_scores_gemma":[0.00005477591,0.000191098,0.0001285218,0.0002756066,0.0002059239,0.0001031521,0.00007055033,0.0003649706,0.000003399771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001077434,"about_ca_system_score_gemma":0.0002815538,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01338334,"about_ca_topic_score_gemma":0.001483627,"domain_scores_codex":[0.9979999,0.0001535118,0.0005550032,0.0004054682,0.0003809135,0.0005051808],"domain_scores_gemma":[0.9985852,0.000109673,0.0003140248,0.000409444,0.0002763665,0.000305246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000987664,0.000541156,0.07575314,0.005664644,0.001012143,0.00001289488,0.01181995,0.001429433,0.257249,0.02395998,0.02512429,0.5964457],"study_design_scores_gemma":[0.005355417,0.00002723842,0.2102104,0.0005752015,0.001279052,0.00001012724,0.0003618769,0.003977885,0.06055494,0.0003797024,0.7168692,0.0003988504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6887402,0.2948236,0.0003170744,0.00937766,0.002915053,0.0009849746,0.0001372809,0.00007905942,0.002625059],"genre_scores_gemma":[0.9607493,0.02807182,0.0006032748,0.006312642,0.002605872,0.0005924141,0.000009335135,0.00005889503,0.0009964206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.691745,"threshold_uncertainty_score":0.9931867,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2125534292","doi":"10.1186/2049-3002-2-s1-p27","title":"Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Glutamine; mTORC1; Prostate cancer; Metabolism; Cell growth; Cancer; Cell metabolism; Prostate; Biochemistry; Medicine; Cancer research; Bioinformatics; Biology; Computational biology; Amino acid; Internal medicine; Signal transduction; PI3K/AKT/mTOR pathway","authors":[{"name":"Qian Wang","is_ca":false},{"name":"Rae‐Anne Hardie","is_ca":false},{"name":"Seher Balaban","is_ca":false},{"name":"Mark Schreuder","is_ca":false},{"name":"Andrew J. Hoy","is_ca":false},{"name":"Michelle van Geldermalsen","is_ca":false},{"name":"Ladan Fazli","is_ca":true},{"name":"Rajini Nagarajah","is_ca":false},{"name":"Charles G. Bailey","is_ca":false},{"name":"John E.J. Rasko","is_ca":false},{"name":"Jeff Holst","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005402664070765974,"gpt":0.2246966580319831,"spread":0.2192939939612171,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003838751,0.0004079542,0.0006917181,0.0001752921,0.00006737417,0.00002788713,0.0001936097,0.0002208891,0.00005465727],"category_scores_gemma":[0.0000771362,0.0003714426,0.0001346596,0.0003245263,0.0002303727,0.00003037192,0.0001752658,0.0001869788,0.000002456407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001952842,"about_ca_system_score_gemma":0.0001209895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008193961,"about_ca_topic_score_gemma":0.0002148027,"domain_scores_codex":[0.9977981,0.0001221697,0.0005957718,0.0006932748,0.0002559111,0.000534771],"domain_scores_gemma":[0.9988409,0.00001623214,0.0003125956,0.0004104532,0.0002351189,0.0001846685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001643417,0.00009131277,0.002740617,0.0001600972,0.00006114223,0.000002319848,0.0003787444,0.0001442971,0.9738701,0.001571391,0.0008452265,0.01997044],"study_design_scores_gemma":[0.002510007,0.00004913339,0.08102437,0.00005738668,0.0001492856,0.000005003773,0.00007165447,0.00009391864,0.7747356,0.0004211843,0.1404764,0.0004059701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9181588,0.0797677,0.0001660328,0.0002193942,0.0005842073,0.0003635012,0.0001699002,0.0000199784,0.0005505169],"genre_scores_gemma":[0.9718618,0.02430179,0.0005914976,0.0004293825,0.0009932183,0.0001952371,0.0000986488,0.00007004199,0.001458387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1991344,"threshold_uncertainty_score":0.9998738,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2166026325","doi":"10.1186/2049-3002-2-s1-p90","title":"Metformin inhibits urothelial tumorigenesis in the UPII-mutant Ha-ras transgenic mouse model","year":2014,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Metformin; Genetically modified mouse; Medicine; Bladder cancer; Cancer; Population; Urothelial Cell; Urinary system; Transgene; Internal medicine; Urology; Pathology; Endocrinology; Biology; Diabetes mellitus; Genetics","authors":[{"name":"Zhongbo Liu","is_ca":false},{"name":"Noriko Yokoyama","is_ca":false},{"name":"Michaël Pollak","is_ca":true},{"name":"Xiaolin Zi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01312948846200331,"gpt":0.256229865475281,"spread":0.2431003770132777,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008097373,0.0003926398,0.0005010852,0.0001006572,0.0001307059,0.000059074,0.0006737487,0.0001873451,0.00008470112],"category_scores_gemma":[0.00007032636,0.0002913174,0.000272795,0.0002671916,0.0001315785,0.000018897,0.00006504971,0.0002351206,0.00001953119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002848542,"about_ca_system_score_gemma":0.0002859381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001704224,"about_ca_topic_score_gemma":0.0004484337,"domain_scores_codex":[0.9975919,0.0002442666,0.0004744645,0.0006414893,0.0003855952,0.000662326],"domain_scores_gemma":[0.9988229,0.00002121245,0.0001369288,0.000764522,0.0001076102,0.0001468832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002209879,0.000164539,0.0002285826,0.00006772805,0.0001385631,0.000001562893,0.001119927,0.003613019,0.8262766,0.002769884,0.002425471,0.1629731],"study_design_scores_gemma":[0.001233159,0.00003216718,0.0002802904,0.00001127338,0.000119678,0.000001892165,0.00006858029,0.0006811863,0.6232208,0.0006325894,0.373357,0.0003613988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8586527,0.1377528,0.001768849,0.0001188898,0.0005939986,0.0004003213,0.0001595629,0.00002197188,0.0005309882],"genre_scores_gemma":[0.9286012,0.0646636,0.0003465395,0.003264857,0.001733916,0.000559875,0.00004709697,0.00008275267,0.0007001755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3709315,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}