{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":490,"total_is_capped":false,"direct_labels_cover":3,"predictions_cover":490,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"ee89edce7903","filters":{"venue":"Clinical Pharmacology & Therapeutics"}},"results":[{"id":"W2161620765","doi":"10.1002/cpt.147","title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2D6</i> and <i>CYP2C19</i> Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors","year":2015,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":975,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Heart, Lung, and Blood Institute","keywords":"Fluvoxamine; Escitalopram; Citalopram; CYP2C19; Paroxetine; Pharmacogenetics; Sertraline; Dosing; Medicine; Pharmacology; CYP2D6; Fluoxetine; Psychiatry; Anxiety; Serotonin; Internal medicine; Genotype; Antidepressant; Biology","authors":[{"name":"J K Hicks","is_ca":false},{"name":"JR Bishop","is_ca":false},{"name":"Katrin Sangkuhl","is_ca":false},{"name":"Müller Dj","is_ca":true},{"name":"Yuan Ji","is_ca":false},{"name":"SG Leckband","is_ca":false},{"name":"JS Leeder","is_ca":false},{"name":"RL Graham","is_ca":false},{"name":"DL Chiulli","is_ca":false},{"name":"Adrián LLerena","is_ca":false},{"name":"TC Skaar","is_ca":false},{"name":"Stuart A. Scott","is_ca":false},{"name":"Julia Stingl","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"KE Caudle","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.294731120690238,"gpt":0.567269353284168,"spread":0.2725382325939301,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006587692,0.0006344956,0.001312723,0.0001957504,0.0003257792,0.00003699653,0.0004532022,0.0008882878,0.0001330033],"category_scores_gemma":[0.0001454523,0.0006249586,0.0003514998,0.0003491971,0.001798628,0.000162047,0.0003736239,0.001444692,0.00001281067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006332676,"about_ca_system_score_gemma":0.0006200427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001560752,"about_ca_topic_score_gemma":0.00001395119,"domain_scores_codex":[0.9922379,0.002166788,0.00326631,0.001065854,0.0003264328,0.0009367266],"domain_scores_gemma":[0.9937359,0.002579168,0.00123665,0.0002974693,0.001112836,0.001037944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00837423,0.002675355,0.2688298,0.0002290988,0.005837528,0.00004021956,0.002273371,0.0004694693,0.237207,0.0002578701,0.1596176,0.3141884],"study_design_scores_gemma":[0.02283885,0.001601697,0.004457869,0.00001468839,0.005531495,0.00004491702,0.0005062493,0.007547289,0.1670799,0.001218958,0.7883738,0.0007841996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672964,0.01425515,0.001321326,0.005628859,0.007798996,0.002771606,0.0004655329,0.0001266911,0.000335463],"genre_scores_gemma":[0.8777315,0.02286135,0.01005431,0.08552342,0.003185778,0.0002358772,0.0001218696,0.0001512437,0.0001346798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6287562,"threshold_uncertainty_score":0.9996202,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2561831579","doi":"10.1002/cpt.597","title":"Clinical pharmacogenetics implementation consortium guideline (CPIC) for <i>CYP2D6</i> and <i>CYP2C19</i> genotypes and dosing of tricyclic antidepressants: 2016 update","year":2016,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":678,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institute of Mental Health; Agency for Healthcare Research and Quality; National Institutes of Health","keywords":"Dosing; Pharmacogenetics; Guideline; CYP2C19; CYP2D6; Tricyclic; Medicine; Pharmacology; Internal medicine; Genotype; Biology; Genetics","authors":[{"name":"JK Hicks","is_ca":false},{"name":"Katrin Sangkuhl","is_ca":false},{"name":"JJ Swen","is_ca":false},{"name":"VL Ellingrod","is_ca":false},{"name":"Müller Dj","is_ca":true},{"name":"Kazutaka Shimoda","is_ca":false},{"name":"JR Bishop","is_ca":false},{"name":"E D Kharasch","is_ca":false},{"name":"TC Skaar","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false},{"name":"Henry M. Dunnenberger","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"KE Caudle","is_ca":false},{"name":"Julia Stingl","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1937910252892181,"gpt":0.5511572408294994,"spread":0.3573662155402813,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004780563,0.0006450521,0.001364141,0.0002148268,0.0003629215,0.00003081671,0.0005761834,0.0008013642,0.0006058803],"category_scores_gemma":[0.0001165436,0.0005049568,0.000420761,0.0002520011,0.002203336,0.0002038914,0.0004179172,0.0008344682,0.00002935987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003381041,"about_ca_system_score_gemma":0.0003142614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006969345,"about_ca_topic_score_gemma":0.000005090269,"domain_scores_codex":[0.9921231,0.001995369,0.003418731,0.001156893,0.0002719748,0.001033917],"domain_scores_gemma":[0.9922064,0.004767883,0.001301039,0.000384808,0.0006040597,0.00073583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002730147,0.0009459031,0.09348923,0.00009274479,0.002483299,0.00001614125,0.0001276428,0.00001488533,0.3595782,0.0001379126,0.04565367,0.4947303],"study_design_scores_gemma":[0.02506976,0.0007062894,0.00983905,0.00002887297,0.005384114,0.00003338652,0.00006693172,0.0014197,0.1575995,0.001257132,0.7978602,0.0007351061],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503936,0.02163081,0.005777849,0.01169631,0.006960765,0.002085643,0.001162167,0.0001313431,0.0001615297],"genre_scores_gemma":[0.7508969,0.1628964,0.004733083,0.07867754,0.002268746,0.0001352413,0.00005910681,0.00013103,0.0002019945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7522065,"threshold_uncertainty_score":0.9997402,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2045567622","doi":"10.1067/mcp.2002.121152","title":"Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine","year":2002,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":606,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences","keywords":"Grapefruit juice; Fexofenadine; Chemistry; Pharmacokinetics; Organic anion-transporting polypeptide; Pharmacology; Organic anion transporter 1; Aspartame; Food science; Crossover study; Terfenadine; Oral administration; Biochemistry; Transporter; Medicine","authors":[{"name":"George K. Dresser","is_ca":true},{"name":"David G. Bailey","is_ca":true},{"name":"Brenda F. Leake","is_ca":true},{"name":"Ute I. Schwarz","is_ca":true},{"name":"Paul A. Dawson","is_ca":true},{"name":"David J. Freeman","is_ca":true},{"name":"Richard B. Kim","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08481314750014701,"gpt":0.3684336159384128,"spread":0.2836204684382658,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001572427,0.0003253167,0.0008440531,0.00009111094,0.0001648162,0.00000965565,0.0003728628,0.0002785585,0.005788528],"category_scores_gemma":[0.0001108576,0.0002198433,0.0003769937,0.0005745321,0.0005426274,0.00006584452,0.00003493963,0.0008335266,0.0001717763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005607053,"about_ca_system_score_gemma":0.00018405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000191573,"about_ca_topic_score_gemma":0.0001737456,"domain_scores_codex":[0.9966648,0.0002813017,0.001577131,0.000546967,0.0003681293,0.0005616416],"domain_scores_gemma":[0.9975821,0.0006592782,0.0003691355,0.0004682883,0.0002517319,0.0006694014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005488183,0.007570795,0.1656485,0.0004207547,0.002397064,0.0003425025,0.004442051,0.0000233717,0.766197,0.00006139119,0.01927728,0.02813116],"study_design_scores_gemma":[0.02711539,0.00429735,0.3548358,0.0004540647,0.01289749,0.0000872562,0.001773308,0.003030028,0.241649,0.0004684292,0.351671,0.00172089],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969877,0.00109828,0.0001529141,0.02635102,0.001088783,0.0009900569,0.00003766307,0.0001322175,0.0002720806],"genre_scores_gemma":[0.9439645,0.0009171555,0.0005818845,0.05302853,0.0004018521,0.00002336166,0.00003222275,0.00005605633,0.0009944034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5245479,"threshold_uncertainty_score":0.9951203,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2095161324","doi":"10.1038/clpt.2011.328","title":"Anti-TNF Monoclonal Antibodies in Inflammatory Bowel Disease: Pharmacokinetics-Based Dosing Paradigms","year":2012,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":503,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ulcerative colitis; Monoclonal antibody; Inflammatory bowel disease; Pharmacokinetics; Immunogenicity; Immunology; Crohn's disease; Dosing; Immune system; Disease; Concomitant; Antibody; Inflammation; Tumor necrosis factor alpha; Internal medicine; Pharmacology","authors":[{"name":"Íngrid Ordás","is_ca":false},{"name":"Diane R. Mould","is_ca":false},{"name":"B G Feagan","is_ca":true},{"name":"William J. Sandborn","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09053051746378393,"gpt":0.4243111106123778,"spread":0.3337805931485938,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001272099,0.001177973,0.001777518,0.0002906242,0.0001953584,0.00006484414,0.001128517,0.001282397,0.0002000473],"category_scores_gemma":[0.000041196,0.001123777,0.001446717,0.0002047936,0.001098937,0.00001823454,0.0004144789,0.001509713,0.0002004637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222594,"about_ca_system_score_gemma":0.001603639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.255408e-7,"about_ca_topic_score_gemma":0.000002383199,"domain_scores_codex":[0.9928245,0.002014135,0.002241628,0.001297686,0.0003544332,0.001267595],"domain_scores_gemma":[0.9967853,0.0003968969,0.0009492047,0.0009309225,0.000150278,0.0007874047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004776445,0.008223989,0.1914202,0.03473423,0.01156735,0.004351009,0.00009661223,0.001172812,0.002619941,0.00007822064,0.02225736,0.7187018],"study_design_scores_gemma":[0.002338477,0.00009158086,0.01313523,0.0007835801,0.006419639,0.00001237503,0.000003060119,0.0003122767,0.00009253455,0.00001198487,0.9756056,0.001193658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02763442,0.9663223,0.00004916077,0.0002070189,0.003675837,0.001666724,0.0002631757,0.00008482079,0.00009655477],"genre_scores_gemma":[0.005139589,0.98058,0.0001728872,0.009095104,0.003499124,0.0002923063,0.0008330361,0.0002637412,0.000124251],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9533482,"threshold_uncertainty_score":0.9991212,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2021635654","doi":"10.1038/clpt.2013.2","title":"Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":453,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; National Institute of General Medical Sciences; National Institute of Mental Health; National Heart, Lung, and Blood Institute; American Lebanese Syrian Associated Charities; Canadian Institutes of Health Research; Agency for Healthcare Research and Quality; National Institutes of Health","keywords":"Doxepin; Nortriptyline; Desipramine; Tricyclic; CYP2D6; Pharmacology; Pharmacogenetics; Clomipramine; CYP2C19; Dosing; Active metabolite; Medicine; Imipramine; Pharmacokinetics; Amitriptyline; Genotype; Chemistry; Internal medicine; Antidepressant; Cytochrome P450; Metabolism; Biochemistry","authors":[{"name":"J. Kevin Hicks","is_ca":false},{"name":"Jesse J. Swen","is_ca":false},{"name":"Caroline F. Thorn","is_ca":false},{"name":"Katrin Sangkuhl","is_ca":false},{"name":"E D Kharasch","is_ca":false},{"name":"V L Ellingrod","is_ca":false},{"name":"Todd C. Skaar","is_ca":false},{"name":"D Müller","is_ca":true},{"name":"Andrea Gaedigk","is_ca":false},{"name":"Julia Stingl","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2465648872691833,"gpt":0.5759832517471809,"spread":0.3294183644779976,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003530958,0.0005534602,0.001226909,0.0002080063,0.0003506168,0.0000450257,0.0004719698,0.0007523093,0.001023508],"category_scores_gemma":[0.00009382887,0.0005246054,0.0003515073,0.0002516992,0.001652344,0.0001835253,0.0003439417,0.001107683,0.00003100665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002387461,"about_ca_system_score_gemma":0.000207218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002350261,"about_ca_topic_score_gemma":0.000004511556,"domain_scores_codex":[0.9930208,0.001695253,0.003200647,0.0009479825,0.0002367295,0.0008985967],"domain_scores_gemma":[0.9935886,0.003644929,0.001103476,0.0003013644,0.0006652998,0.0006962896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001241407,0.001287026,0.2178767,0.0001501416,0.003017091,0.00001088183,0.0003529487,0.00007852372,0.2702906,0.00009513534,0.03935469,0.4662449],"study_design_scores_gemma":[0.03031716,0.001327797,0.1023674,0.00002074864,0.008698308,0.00005153976,0.0003623848,0.02898505,0.1328877,0.002236512,0.6915322,0.001213232],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727828,0.01303605,0.001469189,0.004829704,0.004752525,0.002558122,0.0003004723,0.00008973664,0.0001813975],"genre_scores_gemma":[0.8877426,0.04432793,0.006489545,0.05927895,0.001671847,0.0002079187,0.00007479814,0.00009792797,0.0001085175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6521775,"threshold_uncertainty_score":0.9998897,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2030471578","doi":"10.1016/j.clpt.2004.02.011","title":"Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity*1","year":2004,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":434,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Center for Research Resources; National Institute on Drug Abuse","keywords":"CYP2A6; Cotinine; Nicotine; Metabolite; Chemistry; Saliva; Pharmacology; Oral administration; Metabolism; Internal medicine; Cytochrome P450; Medicine; Biochemistry; CYP1A2","authors":[{"name":"D DEMPSEY","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04141083576189477,"gpt":0.4139102460128128,"spread":0.3724994102509181,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009214993,0.0004067159,0.0008352208,0.00008825263,0.0001138801,0.00001651201,0.0007044509,0.000572411,0.0001500166],"category_scores_gemma":[0.00006875292,0.0003789985,0.0004125343,0.0002738236,0.0006864824,0.00002078446,0.0003154622,0.0006519274,0.00006325135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002363738,"about_ca_system_score_gemma":0.0005168783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002393711,"about_ca_topic_score_gemma":0.00001605829,"domain_scores_codex":[0.9967316,0.000683078,0.0009570384,0.0008036495,0.0002694899,0.0005551616],"domain_scores_gemma":[0.998075,0.0001250955,0.0005036697,0.0007204028,0.0002886214,0.0002871774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008369136,0.00243627,0.003947218,0.00001141248,0.001511375,0.000001215873,0.00008654751,0.0002753192,0.9856982,0.0001385642,0.0003163911,0.004740607],"study_design_scores_gemma":[0.006905462,0.001824976,0.01485817,0.000005355595,0.0009974688,0.00002339223,0.00004692223,0.0001068,0.8971341,0.0002635255,0.07739659,0.0004372309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919684,0.002178286,0.002241384,0.001627477,0.001011763,0.0006261978,0.00003629888,0.00005075575,0.0002594171],"genre_scores_gemma":[0.9799882,0.003548554,0.0007591904,0.01368106,0.001547831,0.00004732892,0.00006494485,0.00007832233,0.0002845516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08856407,"threshold_uncertainty_score":0.9998662,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2089354656","doi":"10.1038/clpt.2009.311","title":"Obesity, Inflammation, and Cardiovascular Risk","year":2010,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":421,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Adipose tissue; Context (archaeology); Inflammation; Obesity; Disease; Medicine; Bioinformatics; Epidemiology; Metabolic syndrome; Dysfunctional family; Internal medicine; Endocrinology; Biology","authors":[{"name":"Patrick Mathieu","is_ca":true},{"name":"Isabelle Lemieux","is_ca":true},{"name":"J-P Després","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09156070844176087,"gpt":0.427290571305833,"spread":0.3357298628640721,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001539008,0.0005619138,0.003191091,0.0001883828,0.0001852781,0.00002968671,0.00028099,0.001204398,0.0002702361],"category_scores_gemma":[0.000165358,0.0004323892,0.001817312,0.0002371369,0.0007325204,0.00007747505,0.0001463398,0.001945267,0.0002028571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002908799,"about_ca_system_score_gemma":0.0007647518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004346484,"about_ca_topic_score_gemma":0.000002102684,"domain_scores_codex":[0.9960514,0.0009699251,0.001559083,0.0007014829,0.0003232944,0.000394767],"domain_scores_gemma":[0.9968508,0.0009919843,0.0006447132,0.0007499339,0.0002987646,0.0004638435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004128569,0.0002226175,0.001465888,0.00281915,0.00744561,0.00003336347,0.00002984287,5.841113e-7,0.000002033463,0.00001837491,0.002002999,0.9859182],"study_design_scores_gemma":[0.00158384,0.0001065292,0.001623859,0.0004915522,0.0787534,0.00009772861,0.000004540967,0.00001698289,0.000004541726,0.00007959743,0.9168974,0.0003400707],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002442951,0.9921655,0.00006811751,0.0002608614,0.002832329,0.001668046,0.00006198476,0.0001472897,0.0003528905],"genre_scores_gemma":[0.00002575062,0.9903429,0.0003301074,0.002135995,0.006392129,0.0001245019,0.0001541376,0.00009457059,0.0003998819],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9855782,"threshold_uncertainty_score":0.9998128,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2076194172","doi":"10.1038/sj.clpt.6100056","title":"Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":406,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Public Health Service; Health Canada; Deutsche Forschungsgemeinschaft; Vanderbilt University; GlaxoSmithKline","keywords":"Fexofenadine; Grapefruit juice; Pharmacology; Transporter; CYP3A4; Efflux; Chemistry; Organic anion-transporting polypeptide; Terfenadine; Pharmacokinetics; Biochemistry; Biology; Cytochrome P450; Metabolism; Gene","authors":[{"name":"Hartmut Glaeser","is_ca":false},{"name":"David G. Bailey","is_ca":true},{"name":"George K. Dresser","is_ca":true},{"name":"Jamie Gregor","is_ca":true},{"name":"Ute I. Schwarz","is_ca":true},{"name":"Jerry McGrath","is_ca":true},{"name":"Wooin Lee","is_ca":false},{"name":"Brenda F. Leake","is_ca":false},{"name":"Rommel G. Tirona","is_ca":true},{"name":"R B Kim","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05382730719279665,"gpt":0.4328564595144984,"spread":0.3790291523217017,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001850923,0.0001780715,0.0005636708,0.00008990001,0.00005194877,0.000003161237,0.0001521502,0.0001601341,0.00014414],"category_scores_gemma":[0.000007004713,0.0000987637,0.0003057605,0.0001714565,0.0009387245,0.00003495546,0.00001515754,0.0006946452,0.000002834264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002325723,"about_ca_system_score_gemma":0.00007440744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001899679,"about_ca_topic_score_gemma":0.00003576485,"domain_scores_codex":[0.9983026,0.0001483889,0.000830978,0.0002549925,0.0001534204,0.0003095623],"domain_scores_gemma":[0.9986576,0.0007854797,0.0001698271,0.0001803707,0.00007755181,0.0001291167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03326536,0.00306357,0.724593,0.0001717949,0.001008254,0.0004184344,0.00666604,0.0000190823,0.2189251,0.0001365826,0.001073083,0.01065965],"study_design_scores_gemma":[0.02728925,0.000895947,0.940217,0.000199782,0.001462159,0.00003180639,0.0006460249,0.0002342146,0.02566511,0.0009574007,0.002146632,0.0002547336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949681,0.001112309,0.0008497179,0.001836227,0.0003640105,0.0004926399,0.000004003089,0.00002616427,0.0003467904],"genre_scores_gemma":[0.9932142,0.000953129,0.0003588778,0.005066459,0.0001880095,0.000008057846,0.000006786374,0.00002074524,0.0001836745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2156239,"threshold_uncertainty_score":0.4027466,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4362735831","doi":"10.1002/cpt.2903","title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2D6</i>, <i>CYP2C19</i>, <i>CYP2B6</i>, <i>SLC6A4</i>, and <i>HTR2A</i> Genotypes and Serotonin Reuptake Inhibitor Antidepressants","year":2023,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":403,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Alberta Children's Hospital; University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institutes of Health; Patient-Centered Outcomes Research Institute","keywords":"CYP2C19; Pharmacogenetics; Serotonin reuptake inhibitor; Medicine; CYP2B6; CYP2D6; Guideline; Internal medicine; Genotype; Serotonin; CYP3A4; Biology; Genetics; Cytochrome P450","authors":[{"name":"Chad Bousman","is_ca":true},{"name":"James M. Stevenson","is_ca":false},{"name":"Laura B. Ramsey","is_ca":false},{"name":"Katrin Sangkuhl","is_ca":false},{"name":"J. Kevin Hicks","is_ca":false},{"name":"Jeffrey R. Strawn","is_ca":false},{"name":"Ajeet Singh","is_ca":false},{"name":"Gualberto Ruaño","is_ca":false},{"name":"Daniel J. Müller","is_ca":true},{"name":"Evangelia Eirini Tsermpini","is_ca":false},{"name":"Jacob T. Brown","is_ca":false},{"name":"Gillian C. Bell","is_ca":false},{"name":"J. Steven Leeder","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false},{"name":"Stuart A. Scott","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Kelly E. Caudle","is_ca":false},{"name":"Jeffrey R. Bishop","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.260799143689104,"gpt":0.5708299925254577,"spread":0.3100308488363537,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.008320654,0.001176871,0.001879434,0.0003915741,0.00103293,0.0001336195,0.0009535888,0.001454365,0.0005420597],"category_scores_gemma":[0.0001950854,0.001182822,0.0005922123,0.0009481951,0.002269232,0.0002983414,0.0009199998,0.002394302,0.0001824964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005743818,"about_ca_system_score_gemma":0.0005116417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001477557,"about_ca_topic_score_gemma":0.00002141272,"domain_scores_codex":[0.9881504,0.002678436,0.004376078,0.002149621,0.0005563025,0.002089121],"domain_scores_gemma":[0.9909659,0.004663874,0.001278668,0.0006706145,0.0009446402,0.001476312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003543274,0.001495845,0.1462594,0.0002746657,0.003985549,0.000153556,0.0006385595,0.0002585811,0.2164234,0.000146427,0.405865,0.2209557],"study_design_scores_gemma":[0.01941957,0.0008387112,0.01211237,0.0000215037,0.004607944,0.00006439245,0.0002729079,0.008978627,0.05938951,0.0007241533,0.8923309,0.001239402],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9485161,0.01344638,0.000696018,0.01483019,0.01511685,0.004602026,0.001651451,0.0007327212,0.0004082561],"genre_scores_gemma":[0.5453092,0.1661984,0.005842716,0.2710487,0.008424581,0.001003894,0.000778728,0.0004667325,0.0009270321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4864659,"threshold_uncertainty_score":0.9999072,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3114326816","doi":"10.1002/cpt.2149","title":"Clinical Pharmacogenetics Implementation Consortium Guideline for <i>CYP2D6</i>, <i>OPRM1</i>, and <i>COMT</i> Genotypes and Select Opioid Therapy","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":399,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Mental Health Research Canada; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Health and Medical Research Council; National Institute of General Medical Sciences; Medical Research Council; National Institutes of Health","keywords":"Pharmacogenetics; CYP2D6; Guideline; Opioid; Medicine; Pharmacology; Genotype; Internal medicine; Biology; Genetics; Gene; Cytochrome P450","authors":[{"name":"Kristine R. Crews","is_ca":false},{"name":"Andrew A. Monte","is_ca":false},{"name":"Rachel Huddart","is_ca":false},{"name":"Kelly E. Caudle","is_ca":false},{"name":"Evan D. Kharasch","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false},{"name":"Henry M. Dunnenberger","is_ca":false},{"name":"J. Steven Leeder","is_ca":false},{"name":"John T. Callaghan","is_ca":false},{"name":"Caroline Samer","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Cyrine E. Haidar","is_ca":false},{"name":"Sara L. Van Driest","is_ca":false},{"name":"Gualberto Ruaño","is_ca":false},{"name":"Katrin Sangkuhl","is_ca":false},{"name":"Larisa H. Cavallari","is_ca":false},{"name":"Daniel J. Müller","is_ca":true},{"name":"Cynthia A. Prows","is_ca":false},{"name":"Mohamed Nagy","is_ca":false},{"name":"Andrew A. Somogyi","is_ca":false},{"name":"Todd C. Skaar","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2469155098123062,"gpt":0.5716757893882056,"spread":0.3247602795758995,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004569361,0.0008017036,0.00137997,0.0001412845,0.0006910145,0.00009414027,0.0005364245,0.001012151,0.001156237],"category_scores_gemma":[0.00008971478,0.0007936067,0.0005182908,0.000381398,0.001456141,0.0001569123,0.0004200144,0.001847929,0.00003908906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004245484,"about_ca_system_score_gemma":0.0007246626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000646132,"about_ca_topic_score_gemma":0.00001453749,"domain_scores_codex":[0.991086,0.002789982,0.003007169,0.001534876,0.0003131142,0.001268879],"domain_scores_gemma":[0.9929993,0.003781163,0.0007992917,0.0004305889,0.0009927721,0.0009968415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002780423,0.002200779,0.08549385,0.0001101689,0.004896851,0.0001021219,0.0005170659,0.00008363484,0.2692138,0.0002113341,0.1242036,0.5101864],"study_design_scores_gemma":[0.01794974,0.0006702697,0.005000585,0.000006627184,0.003055254,0.00009454004,0.0001494598,0.003713416,0.1082385,0.0009789019,0.8593667,0.0007760694],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.8989444,0.06881089,0.001992554,0.01497776,0.01144066,0.002460918,0.0007252202,0.0002393479,0.0004082122],"genre_scores_gemma":[0.2782474,0.3021083,0.0108999,0.4022786,0.005099182,0.0003386172,0.0003712164,0.0002122815,0.0004445103],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.735163,"threshold_uncertainty_score":0.9997568,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2562778159","doi":"10.1002/cpt.583","title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for <i>CYP2C19</i> and Voriconazole Therapy","year":2016,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":393,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Cancer Institute; Children's Mercy Hospital; National Institutes of Health; Sick Kids Foundation; Instituto de Salud Carlos III; Federación Española de Enfermedades Raras","keywords":"CYP2C19; Pharmacogenetics; Voriconazole; Medicine; Medical physics; Internal medicine; Biology; Genotype","authors":[{"name":"Brad Moriyama","is_ca":false},{"name":"Aniwaa Owusu Obeng","is_ca":false},{"name":"Julia M. Barbarino","is_ca":false},{"name":"SR Penzak","is_ca":false},{"name":"SA Henning","is_ca":false},{"name":"Stuart A. Scott","is_ca":false},{"name":"John R. Wingard","is_ca":false},{"name":"HL McLeod","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Shane J. Cross","is_ca":false},{"name":"KE Caudle","is_ca":false},{"name":"TJ Walsh","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3670090222705866,"gpt":0.582856070294495,"spread":0.2158470480239084,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002146236,0.0002944042,0.0007581331,0.00005039683,0.0001477461,0.00001466013,0.0001811266,0.0003304738,0.0005423257],"category_scores_gemma":[0.0001516518,0.0001918981,0.0004142993,0.0001029447,0.0009088797,0.00008005611,0.00006896941,0.0003111729,0.00004093764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004053504,"about_ca_system_score_gemma":0.0003283859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002176004,"about_ca_topic_score_gemma":0.00000654004,"domain_scores_codex":[0.9963878,0.0003901955,0.001788714,0.0007123697,0.0002180498,0.0005028671],"domain_scores_gemma":[0.9957146,0.002329953,0.0003551358,0.0003338107,0.0009161065,0.0003504044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003043964,0.0005983165,0.5648541,0.00002892346,0.0008366126,0.000008170625,0.00002508283,1.447375e-7,0.06212907,0.00002779621,0.06600951,0.3024383],"study_design_scores_gemma":[0.02639239,0.002716371,0.3070942,0.00003144393,0.001621371,0.00001595161,0.0001178554,0.0001759901,0.02276247,0.0005802714,0.6381019,0.0003897208],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9452974,0.003758603,0.004389052,0.04242135,0.002336192,0.001518001,0.0000973728,0.0001016068,0.00008039925],"genre_scores_gemma":[0.7665041,0.05223503,0.003534174,0.1744117,0.002383937,0.00009245159,0.00002312539,0.00005571568,0.0007597104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5720924,"threshold_uncertainty_score":0.7825377,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2027255015","doi":"10.1038/clpt.2013.74","title":"Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium","year":2013,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":345,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Multidrug resistance-associated protein 2; Transporter; Bile Salt Export Pump; Abcg2; Pharmacology; Efflux; Drug; ATP-binding cassette transporter; Cholestasis; Pharmacokinetics; Chemistry; Medicine; Biochemistry; Internal medicine; Gene","authors":[{"name":"Kathleen M. Hillgren","is_ca":false},{"name":"Dietrich Keppler","is_ca":false},{"name":"A. Zur","is_ca":false},{"name":"Kathleen M. Giacomini","is_ca":false},{"name":"Bruno Stieger","is_ca":false},{"name":"Carol E. Cass","is_ca":true},{"name":"L Zhang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2187098658280976,"gpt":0.5060868766921303,"spread":0.2873770108640327,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.002100624,0.0007477484,0.004351147,0.0001052209,0.00009826715,0.00001954658,0.001330675,0.001333578,0.004194701],"category_scores_gemma":[0.00001354022,0.0004580714,0.002842097,0.0002328616,0.001255724,0.0001224109,0.00003412957,0.002686786,0.00009773424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004455243,"about_ca_system_score_gemma":0.0009349567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001012265,"about_ca_topic_score_gemma":0.00003031692,"domain_scores_codex":[0.9916028,0.0006315047,0.005520103,0.001103219,0.0005829569,0.0005594324],"domain_scores_gemma":[0.9951581,0.001302555,0.001877522,0.0009414276,0.0002799941,0.0004403553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001102596,0.002174263,0.01378081,0.001389013,0.01286821,0.0003344959,0.000197161,8.095108e-7,0.000049323,0.00003875059,0.008516603,0.9595479],"study_design_scores_gemma":[0.003121464,0.0003811347,0.002541685,0.001258022,0.02389753,0.00001654469,0.00008013758,0.00004519392,0.00001823686,0.00008400904,0.9681256,0.0004303846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01022907,0.9681966,0.0003338079,0.004720885,0.01330468,0.002237884,0.0006096607,0.0001311782,0.000236217],"genre_scores_gemma":[0.0008531241,0.9635075,0.0008872534,0.02946212,0.003062238,0.0001127886,0.001679572,0.0001479094,0.0002874522],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.959609,"threshold_uncertainty_score":0.9999629,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1971946342","doi":"10.1038/clpt.2013.103","title":"Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institutes of Health; National Heart, Lung, and Blood Institute; U.S. Department of Veterans Affairs; National Institute for Health and Care Research; St. Jude Children's Research Hospital","keywords":"Pharmacogenetics; Dosing; Carbamazepine; Medicine; Genotype; Pharmacology; Human leukocyte antigen; Immunology; Biology; Genetics; Epilepsy; Psychiatry; Gene; Antigen","authors":[{"name":"Susan G. Leckband","is_ca":false},{"name":"John R. Kelsoe","is_ca":false},{"name":"Henry M. Dunnenberger","is_ca":false},{"name":"Alfred L. George","is_ca":false},{"name":"Eric Tran","is_ca":false},{"name":"Reisel Berger","is_ca":false},{"name":"D Müller","is_ca":true},{"name":"Michelle Whirl‐Carrillo","is_ca":false},{"name":"Kelly E. Caudle","is_ca":false},{"name":"Munir Pirmohamed","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3055617217804912,"gpt":0.5670369111085714,"spread":0.2614751893280801,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009206721,0.0002974334,0.0007102322,0.0001003649,0.000177498,0.00002906772,0.0001445055,0.0003487762,0.0002374491],"category_scores_gemma":[0.0001433856,0.0002666058,0.0003228198,0.0001559781,0.0005208153,0.000112042,0.00009686939,0.0006244853,0.0001010841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006574909,"about_ca_system_score_gemma":0.0003294341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002064186,"about_ca_topic_score_gemma":0.000005862616,"domain_scores_codex":[0.9966048,0.0002957606,0.00180111,0.000595244,0.000186976,0.0005161263],"domain_scores_gemma":[0.9962919,0.001441739,0.0004103877,0.0002794391,0.001136016,0.0004404616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002728164,0.001058334,0.07080421,0.00009715499,0.002895465,0.00001700021,0.0001092861,0.00001730346,0.1702511,0.00002817736,0.04415649,0.7102927],"study_design_scores_gemma":[0.01821826,0.0008091338,0.2040745,0.00003452526,0.006982169,0.00009988892,0.0004167061,0.009504016,0.009066663,0.0003188048,0.7499442,0.0005311606],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478236,0.001385491,0.001907935,0.04019284,0.005145687,0.002913201,0.00005196857,0.0001790583,0.0004001536],"genre_scores_gemma":[0.7604268,0.01010407,0.0226179,0.2003814,0.005279634,0.0002943387,0.0001385747,0.0001318292,0.0006255263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7097615,"threshold_uncertainty_score":0.9999786,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2159542081","doi":"10.1038/clpt.2008.157","title":"Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case–Control Study","year":2008,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Maternal Mental Health During Pregnancy and Postpartum","field":"Medicine","cited_by":306,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; University of British Columbia; SickKids Foundation; Pacific Centre for Reproductive Medicine; Western University","funders":"Genome British Columbia","keywords":"Medicine; Breastfeeding; Codeine; Opiate; Opioid; Depression (economics); Pediatrics; Asymptomatic; Anesthesia; Obstetrics; Internal medicine; Morphine","authors":[{"name":"P Madadi","is_ca":true},{"name":"Michael R. Hayden","is_ca":true},{"name":"Bruce Carleton","is_ca":true},{"name":"Andrea Gaedigk","is_ca":false},{"name":"JS Leeder","is_ca":false},{"name":"Gideon Koren","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1108231251555927,"gpt":0.4146204736921658,"spread":0.303797348536573,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004945077,0.0002784221,0.0009350047,0.0001138658,0.000151878,0.000004747624,0.0001878201,0.0001825724,0.0002187445],"category_scores_gemma":[0.00001913291,0.0002503217,0.000308945,0.0001455814,0.0003341168,0.00009279803,0.0001149981,0.0005656885,0.000007327416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004013995,"about_ca_system_score_gemma":0.0001306211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003912531,"about_ca_topic_score_gemma":0.00000343104,"domain_scores_codex":[0.9969729,0.0003992933,0.001465626,0.0003727232,0.0003422023,0.0004473001],"domain_scores_gemma":[0.9982137,0.0005897907,0.0004723341,0.0002652131,0.0001556555,0.0003032736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006419191,0.002518588,0.946587,0.0007528166,0.002159995,0.007313783,0.0006707755,0.00005564703,0.03203946,7.134539e-7,0.00003298113,0.001449095],"study_design_scores_gemma":[0.02042714,0.003958785,0.8357015,0.0004422286,0.003393515,0.00587553,0.00007399898,0.00107855,0.1285212,0.000005246185,0.0002437451,0.0002784612],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955786,0.0009290916,0.0001004143,0.0004378004,0.001634056,0.001143285,0.0001131497,0.00005166862,0.00001190355],"genre_scores_gemma":[0.9945313,0.0007995375,0.0004367299,0.003604862,0.0003962746,0.00002569698,0.000002949613,0.00004303788,0.0001595817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1108854,"threshold_uncertainty_score":0.9999949,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2794417831","doi":"10.1002/cpt.1004","title":"Clinical Pharmacogenetics Implementation Consortium Guideline for <i>HLA</i> Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update","year":2018,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":302,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; BC Children's Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Medical Research Council; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; Canada Foundation for Innovation; National Institute of Allergy and Infectious Diseases; Australian Centre for HIV and Hepatitis Virology Research","keywords":"Oxcarbazepine; Carbamazepine; Toxic epidermal necrolysis; Pharmacogenetics; Medicine; Genotype; Allele; Eosinophilia; Pharmacology; Guideline; Human leukocyte antigen; Epilepsy; Immunology; Dermatology; Genetics; Psychiatry; Biology; Pathology; Gene","authors":[{"name":"Elizabeth J. Phillips","is_ca":false},{"name":"Chonlaphat Sukasem","is_ca":false},{"name":"Michelle Whirl‐Carrillo","is_ca":false},{"name":"Daniel J. Müller","is_ca":true},{"name":"Henry M. Dunnenberger","is_ca":false},{"name":"Wasun Chantratita","is_ca":false},{"name":"Barry R. Goldspiel","is_ca":false},{"name":"Yuan‐Tsong Chen","is_ca":false},{"name":"Bruce Carleton","is_ca":true},{"name":"Alfred L. George","is_ca":false},{"name":"Taisei Mushiroda","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Roseann S. Gammal","is_ca":false},{"name":"Munir Pirmohamed","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1847197132860234,"gpt":0.5213460437019938,"spread":0.3366263304159705,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001295486,0.0002826013,0.0008129271,0.0001079726,0.0001371381,0.00001586918,0.0001236792,0.0003279745,0.00007299955],"category_scores_gemma":[0.0001254049,0.0002617376,0.0002173301,0.0001485865,0.001434814,0.0001113281,0.0001425691,0.0004689988,0.00001494932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003285733,"about_ca_system_score_gemma":0.0003028435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001353288,"about_ca_topic_score_gemma":0.00001548339,"domain_scores_codex":[0.996568,0.0003070196,0.001942254,0.0005932823,0.000173233,0.0004162174],"domain_scores_gemma":[0.9965687,0.001253279,0.0006238024,0.0003382744,0.0008433523,0.0003725848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002535938,0.002122454,0.1417214,0.0002142436,0.00603738,0.00004101776,0.0002204832,0.000007264832,0.3388387,0.0001151832,0.1003748,0.4077711],"study_design_scores_gemma":[0.01284347,0.001206056,0.05746328,0.00002162562,0.005869805,0.00007487086,0.00007431907,0.003987157,0.01327439,0.0000976002,0.9047902,0.0002972566],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785134,0.001143691,0.002319529,0.01228607,0.003373118,0.001838343,0.0002903905,0.00008710201,0.0001483367],"genre_scores_gemma":[0.8432775,0.02123516,0.02596026,0.1055197,0.003412232,0.00005997454,0.0002339645,0.0001019019,0.0001993855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8044153,"threshold_uncertainty_score":0.9999835,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2134431157","doi":"10.1038/sj.clpt.6100104","title":"Naringin is a Major and Selective Clinical Inhibitor of Organic Anion-Transporting Polypeptide 1A2 (OATP1A2) in Grapefruit Juice","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"National Institute of General Medical Sciences","keywords":"Grapefruit juice; Fexofenadine; Naringin; Chemistry; Bioavailability; Pharmacology; Orange juice; Hesperidin; Pharmacokinetics; Chromatography; Food science; Medicine","authors":[{"name":"David G. Bailey","is_ca":true},{"name":"George K. Dresser","is_ca":true},{"name":"Brenda F. Leake","is_ca":false},{"name":"R B Kim","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05285124708051807,"gpt":0.4164629260516325,"spread":0.3636116789711144,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002932324,0.0003149606,0.001089807,0.000208924,0.00008180103,0.0000060982,0.0001939166,0.0006181448,0.0001506249],"category_scores_gemma":[0.00003813264,0.0002789571,0.000336265,0.0005820983,0.0006569205,0.00006944428,0.00004103414,0.001406853,0.00001437444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005689489,"about_ca_system_score_gemma":0.0002733683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001237887,"about_ca_topic_score_gemma":0.0001854951,"domain_scores_codex":[0.9960038,0.0001890213,0.002227702,0.0006590041,0.0002838084,0.0006366551],"domain_scores_gemma":[0.9977289,0.001005643,0.00046527,0.0002517972,0.0002097044,0.000338617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003953152,0.001847981,0.8567423,0.0001542068,0.0008705548,0.0002914254,0.0008535467,5.198436e-7,0.1283846,0.00003589317,0.0004200596,0.006445807],"study_design_scores_gemma":[0.0141302,0.002067187,0.8672891,0.0002297909,0.002472228,0.00005556969,0.0005536303,0.0001012622,0.1041421,0.000439165,0.008029156,0.0004906812],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926714,0.001181572,0.0008167354,0.003031065,0.001249656,0.0007098115,0.00001064545,0.00007891765,0.000250151],"genre_scores_gemma":[0.9744591,0.001522663,0.001588382,0.02144736,0.000643124,0.000008218892,0.00001060035,0.00006318297,0.0002573773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02424255,"threshold_uncertainty_score":0.9999663,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2015234747","doi":"10.1016/j.clpt.2006.02.006","title":"Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation","year":2006,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":276,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Cancer Institute; National Center for Research Resources; National Institute on Drug Abuse; U.S. Public Health Service","keywords":"Cotinine; Nicotine; CYP2A6; Odds ratio; Smoking cessation; Medicine; Metabolite; Confidence interval; Abstinence; Pharmacology; Internal medicine; Nicotine withdrawal; Physiology; Metabolism; Cytochrome P450; Psychiatry; CYP1A2","authors":[{"name":"Caryn Lerman","is_ca":true},{"name":"Rachel F. Tyndale","is_ca":true},{"name":"Freda Patterson","is_ca":true},{"name":"E. Paul Wileyto","is_ca":true},{"name":"Peter G. Shields","is_ca":true},{"name":"António Pinto","is_ca":true},{"name":"Neal L. Benowitz","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08963809978074626,"gpt":0.42237025566641,"spread":0.3327321558856637,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008531205,0.0002159252,0.0006051867,0.0001128475,0.00009750418,0.00001075497,0.0001471454,0.0003446861,0.0001495936],"category_scores_gemma":[0.00003219521,0.0001943527,0.0003560878,0.0002246364,0.0002856514,0.00008855783,0.00001934038,0.0004140357,0.000001731406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004174281,"about_ca_system_score_gemma":0.000148712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008550174,"about_ca_topic_score_gemma":0.000001601322,"domain_scores_codex":[0.9976549,0.0002012328,0.001157905,0.0003718173,0.0002825768,0.0003315769],"domain_scores_gemma":[0.9980743,0.0008695344,0.0003946493,0.0002318485,0.000333786,0.00009588882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003697177,0.005004377,0.6715232,0.0002190058,0.001323232,0.000004539353,0.0002985298,0.0005056505,0.2898525,0.0003707248,0.004396915,0.02280418],"study_design_scores_gemma":[0.02018632,0.0009282941,0.7033731,0.00003725323,0.007221463,0.00001114473,0.00002503639,0.002298172,0.2480987,0.00016899,0.01742873,0.0002228117],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863377,0.0004588301,0.006775755,0.003324869,0.001779592,0.000992157,0.00004507868,0.0001148235,0.0001712047],"genre_scores_gemma":[0.990945,0.0001998835,0.0004461482,0.006199194,0.001568103,0.00005712294,0.0003272209,0.00004495339,0.0002124145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04175379,"threshold_uncertainty_score":0.7925472,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2046426458","doi":"10.1038/clpt.2011.345","title":"Adaptive Licensing: Taking the Next Step in the Evolution of Drug Approval","year":2012,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":270,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canadian Agency for Drugs and Technologies in Health; Health Canada","funders":"","keywords":"Transformative learning; Legislature; Clinical pharmacology; Engineering ethics; Action (physics); Drug approval; Management science; Computer science; Risk analysis (engineering); Medicine; Psychology; Political science; Drug; Pharmacology; Law; Engineering","authors":[{"name":"H-G Eichler","is_ca":false},{"name":"Kenneth A. Oye","is_ca":false},{"name":"L G Baird","is_ca":false},{"name":"Éric Abadie","is_ca":false},{"name":"Jeffrey S. Brown","is_ca":false},{"name":"Chester Lee Drum","is_ca":false},{"name":"John G. Ferguson","is_ca":false},{"name":"S Garner","is_ca":false},{"name":"Peter K. Honig","is_ca":false},{"name":"Mathias Hukkelhoven","is_ca":false},{"name":"John C. W. Lim","is_ca":false},{"name":"Robyn Lim","is_ca":true},{"name":"Murray Lumpkin","is_ca":false},{"name":"G L Neil","is_ca":false},{"name":"Brian O’Rourke","is_ca":true},{"name":"Edmund J. Pezalla","is_ca":false},{"name":"D Shoda","is_ca":false},{"name":"Vicki Seyfert‐Margolis","is_ca":false},{"name":"Ellen V. Sigal","is_ca":false},{"name":"J. Sobotka","is_ca":false},{"name":"Derek S. Tan","is_ca":false},{"name":"T F Unger","is_ca":false},{"name":"Gigi Hirsch","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.7984869042927707,"gpt":0.5808708196287621,"spread":0.2176160846640086,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.04432295,0.000450764,0.003391482,0.0002847982,0.000222475,0.00004462305,0.001333015,0.0006778114,0.0002309859],"category_scores_gemma":[0.0004939149,0.0003367194,0.0008410473,0.0005107607,0.0006803138,0.0002290457,0.0001631681,0.001844902,0.0007625154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000835238,"about_ca_system_score_gemma":0.0006609656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001975938,"about_ca_topic_score_gemma":0.00006244235,"domain_scores_codex":[0.9836757,0.006467178,0.008383934,0.0006788873,0.0001387267,0.0006555421],"domain_scores_gemma":[0.9747201,0.01505187,0.009207051,0.0008174928,0.00009219015,0.0001112813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002672983,0.004349164,0.006364602,0.01728936,0.00784076,0.00001123461,0.01627546,0.0001129305,5.582158e-7,0.05646063,0.1039018,0.7871262],"study_design_scores_gemma":[0.0005976205,0.00008733256,0.0006629037,0.0005095826,0.0009410346,0.00001119694,0.001322411,0.001301554,3.928845e-8,0.0007268862,0.9935131,0.0003263066],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002600425,0.9783719,0.0006235273,0.01334321,0.003744147,0.002485597,0.0001061637,0.00002504955,0.001040327],"genre_scores_gemma":[0.003631639,0.9424747,0.0004502815,0.05052784,0.00246583,0.0002386041,0.00002364343,0.00007410772,0.0001133254],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8896114,"threshold_uncertainty_score":0.9999085,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2050094658","doi":"10.1038/clpt.2008.59","title":"Emerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport","year":2008,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":270,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"","keywords":"Drug metabolism; Kidney disease; Transporter; Medicine; Drug; Kidney; Disease; Metabolism; Pharmacology; Renal function; Gastrointestinal tract; Efflux; Liver disease; Internal medicine; Biology; Biochemistry","authors":[{"name":"TD Nolin","is_ca":false},{"name":"Judith Naud","is_ca":true},{"name":"FA Leblond","is_ca":true},{"name":"Vincent Pichette","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1333107435689933,"gpt":0.4807600368480687,"spread":0.3474492932790754,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005299867,0.0004824401,0.002820444,0.0001204689,0.00007696429,0.000001716224,0.0004130799,0.0002912116,0.00013677],"category_scores_gemma":[0.00004791585,0.0002567977,0.002473419,0.000328154,0.0009613689,0.00003486144,0.00003469489,0.001111571,0.000003755478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003997418,"about_ca_system_score_gemma":0.002071772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005515916,"about_ca_topic_score_gemma":4.954965e-7,"domain_scores_codex":[0.9968216,0.0004497501,0.001578239,0.0004852102,0.0003444788,0.0003206543],"domain_scores_gemma":[0.9971778,0.0007469523,0.0008191674,0.0005489292,0.0001342353,0.0005728719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009881006,0.008131938,0.01355002,0.06629883,0.02911847,0.0008208335,0.001068306,0.00003144349,0.0006429024,0.0001326033,0.01867267,0.851651],"study_design_scores_gemma":[0.002489075,0.0004420364,0.008308019,0.01852191,0.03540165,0.00003754778,0.000009506429,0.00002250621,0.0001115293,0.00006223786,0.9341766,0.0004173605],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006885656,0.9890947,0.0000104464,0.001219445,0.001323972,0.001255751,0.0001366629,0.00002386081,0.00004951628],"genre_scores_gemma":[0.006018598,0.9890145,0.00004619774,0.004123045,0.0003606807,0.00002923952,0.00002316935,0.00006526268,0.000319321],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.915504,"threshold_uncertainty_score":0.9999884,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2098436801","doi":"10.1016/j.clpt.2004.10.011","title":"Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence*","year":2005,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":265,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"CYP2A6; Nicotine; Addiction; Context (archaeology); Nicotine dependence; Cotinine; Smoking cessation; Cigarette smoke; Abstinence; Pharmacology; Medicine; Psychology; Psychiatry; Biology; Cytochrome P450; Internal medicine; Environmental health","authors":[{"name":"Viba Malaiyandi","is_ca":true},{"name":"Edward M. Sellers","is_ca":true},{"name":"Rachel F. Tyndale","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1175666542198994,"gpt":0.4839279612909477,"spread":0.3663613070710484,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006850055,0.0004218655,0.001245794,0.00008095253,0.0001065305,0.00001195616,0.0005187385,0.0009979468,0.00004270853],"category_scores_gemma":[0.00005205041,0.0003894073,0.0005939128,0.0001380608,0.0003181821,0.000003841707,0.0002706073,0.0004879091,0.000004397366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003790933,"about_ca_system_score_gemma":0.0003896139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001761019,"about_ca_topic_score_gemma":0.000005511169,"domain_scores_codex":[0.9967927,0.0004230525,0.001532967,0.000776154,0.0001082288,0.0003669294],"domain_scores_gemma":[0.9976645,0.000506065,0.001002942,0.0004812937,0.0002151435,0.0001301285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004919433,0.0006412758,0.0009308032,0.0006466882,0.001617385,1.199174e-7,0.00002179196,0.000005292037,0.002009993,0.00000964235,0.001840659,0.9922271],"study_design_scores_gemma":[0.001192564,0.0005871828,0.0004534708,0.0001389597,0.007891927,0.0000238369,0.000004965847,0.00001813888,0.0003210855,0.00002000619,0.9889771,0.0003707787],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003392357,0.9911195,0.002121547,0.0002990734,0.001004081,0.001827206,0.0001832916,0.00002120445,0.00003175498],"genre_scores_gemma":[0.001296183,0.9916005,0.003048585,0.001638018,0.001620514,0.000330436,0.0002492701,0.00009532319,0.0001212356],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9918564,"threshold_uncertainty_score":0.9998558,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2040550914","doi":"10.1038/sj.clpt.6100087","title":"The Pharmacogenetics Research Network: From SNP Discovery to Clinical Drug Response","year":2007,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":243,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; National Institute on Drug Abuse; Wellcome Trust","keywords":"Pharmacogenomics; Pharmacogenetics; Drug response; Addiction; Clinical pharmacology; Pharmacology; Medicine; Drug; Disease; Informatics; Bioinformatics; Computational biology; Biology; Psychiatry; Genetics; Genotype; Internal medicine; Gene","authors":[{"name":"Kathleen M. Giacomini","is_ca":false},{"name":"Christopher M. A. Brett","is_ca":false},{"name":"Russ B. Altman","is_ca":false},{"name":"N L Benowitz","is_ca":false},{"name":"M. Eileen Dolan","is_ca":false},{"name":"David A. Flockhart","is_ca":false},{"name":"J. A. Johnson","is_ca":false},{"name":"Daniel F. Hayes","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Ronald M. Krauss","is_ca":false},{"name":"Deanna L. Kroetz","is_ca":false},{"name":"Howard L. McLeod","is_ca":false},{"name":"Anne Nguyen","is_ca":false},{"name":"Mark J. Ratain","is_ca":false},{"name":"Mary V. Relling","is_ca":false},{"name":"Victor I. Reus","is_ca":false},{"name":"Dan M. Roden","is_ca":false},{"name":"Cathy Schaefer","is_ca":false},{"name":"Alan R. Shuldiner","is_ca":false},{"name":"Todd C. Skaar","is_ca":false},{"name":"Kelan G. Tantisira","is_ca":false},{"name":"Rachel F. Tyndale","is_ca":true},{"name":"L Wang","is_ca":false},{"name":"Richard M. Weinshilboum","is_ca":false},{"name":"Scott T. Weiss","is_ca":false},{"name":"Issam Zineh","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.7589401969495758,"gpt":0.7016421437167268,"spread":0.05729805323284898,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","open_science","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"category_scores_codex":[0.07682076,0.002365253,0.005889229,0.0007125323,0.003389135,0.0004635007,0.007169912,0.004580963,0.001155505],"category_scores_gemma":[0.000915401,0.001775015,0.003803167,0.002925091,0.0054786,0.0002123746,0.003940679,0.02131774,0.004808514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005300657,"about_ca_system_score_gemma":0.00365392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002136198,"about_ca_topic_score_gemma":0.00003595947,"domain_scores_codex":[0.925787,0.05543238,0.008170812,0.003391727,0.001627984,0.0055901],"domain_scores_gemma":[0.8904784,0.1012699,0.001954361,0.002230344,0.001148229,0.002918727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006060864,0.00142264,0.0002978354,0.0002550903,0.007021886,0.0003432879,0.0001496401,0.00008190406,0.00007137591,0.00004197467,0.3008757,0.6833778],"study_design_scores_gemma":[0.004070446,0.0005690082,0.0001891935,0.0005024668,0.01490715,0.0000368388,0.00006979454,0.0002442358,0.0001618547,0.0004833578,0.9769725,0.001793137],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004151307,0.9150274,0.0001898231,0.00578197,0.06711148,0.005624852,0.001073227,0.0003163076,0.0007235679],"genre_scores_gemma":[0.0001538513,0.8828034,0.000542137,0.07687185,0.0319453,0.0007421684,0.0002068184,0.0005632287,0.006171197],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6815847,"threshold_uncertainty_score":0.9997576,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2976816195","doi":"10.1002/cpt.2166","title":"PharmVar GeneFocus: <i>CYP2B6</i>","year":2021,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":239,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Medical Research Council; National Institutes of Health; Canada Research Chairs; Robert Bosch Stiftung; Horizon 2020 Framework Programme; European Federation of Pharmaceutical Industries and Associations; National Research Foundation; Canadian Institutes of Health Research; Australian Centre for HIV and Hepatitis Virology Research; European Commission; Vetenskapsrådet; Centre for Addiction and Mental Health; McGill University","keywords":"Medicine; Pharmacology","authors":[{"name":"Zeruesenay Desta","is_ca":false},{"name":"Ahmed El‐Boraie","is_ca":true},{"name":"Li Gong","is_ca":false},{"name":"Andrew A. Somogyi","is_ca":false},{"name":"Volker M. Lauschke","is_ca":false},{"name":"Collet Dandara","is_ca":false},{"name":"Kathrin Klein","is_ca":false},{"name":"Neil Miller","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Rachel F. Tyndale","is_ca":true},{"name":"Michelle Whirl‐Carrillo","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.5691523363200172,"gpt":0.6343200664153339,"spread":0.06516773009531673,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.004108607,0.002303081,0.007188663,0.0005076202,0.0007190619,0.000124409,0.002963561,0.004827355,0.01037864],"category_scores_gemma":[0.00008390901,0.002087656,0.004278027,0.001405059,0.001689045,0.0001724262,0.001270007,0.00962592,0.003755967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002948664,"about_ca_system_score_gemma":0.002414423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003733491,"about_ca_topic_score_gemma":0.000001874574,"domain_scores_codex":[0.979748,0.009950183,0.004612271,0.002619416,0.0006498699,0.002420295],"domain_scores_gemma":[0.9893032,0.00507206,0.001993578,0.001331485,0.000592236,0.001707403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001105229,0.002095104,0.00003056792,0.001946376,0.01016023,0.0006627237,0.00008251596,0.00001788776,0.0001363862,0.00006301099,0.1348485,0.8498461],"study_design_scores_gemma":[0.00359774,0.0001966411,0.000002728296,0.0006143333,0.04157354,0.00028095,0.00001985981,0.0001669096,0.0003735046,0.00007785618,0.9511904,0.001905584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008944722,0.953438,0.00008320921,0.001289237,0.03776015,0.002352623,0.0008082735,0.0004844465,0.003694633],"genre_scores_gemma":[0.000009286534,0.8895588,0.0004331197,0.0950757,0.01037928,0.0005547403,0.0005340551,0.0004767165,0.002978308],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8479406,"threshold_uncertainty_score":0.9989708,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2004772633","doi":"10.1038/clpt.2009.201","title":"Sustained Neurobehavioral Effects of Exposure to SSRI Antidepressants During Development: Molecular to Clinical Evidence","year":2009,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Maternal Mental Health During Pregnancy and Postpartum","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Mental Health","keywords":"Serotonergic; Clinical pharmacology; Serotonin reuptake inhibitor; Serotonin; Mood; Fluoxetine; Medicine; Serotonin Uptake Inhibitors; Psychiatry; Sertraline; Psychology; Prenatal exposure; Antidepressant; Pharmacology; Pregnancy; Internal medicine; Anxiety; Biology; Gestation","authors":[{"name":"Tim F. Oberlander","is_ca":true},{"name":"Jay A. Gingrich","is_ca":false},{"name":"Mark S. Ansorge","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09180549067901014,"gpt":0.4731599964903224,"spread":0.3813545058113122,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000787452,0.0002802455,0.000819927,0.0001247633,0.00009767692,0.000009666775,0.0003422378,0.000269837,0.00004413266],"category_scores_gemma":[0.0001479593,0.0002553686,0.0002135769,0.0002448478,0.0001214403,0.00006577273,0.0002045187,0.0006825702,0.00007281455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005547073,"about_ca_system_score_gemma":0.0002169478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001842982,"about_ca_topic_score_gemma":5.240098e-7,"domain_scores_codex":[0.9964254,0.0005549919,0.001503023,0.0005840945,0.0003136839,0.0006187551],"domain_scores_gemma":[0.997769,0.000692446,0.0002376111,0.0003957072,0.0001834009,0.0007218593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01668251,0.004816038,0.779598,0.003162538,0.0004449923,0.002623665,0.0008676841,0.00006164332,0.1543988,0.00001307045,0.0005174638,0.03681364],"study_design_scores_gemma":[0.003327048,0.005118426,0.8088815,0.001844189,0.0004588454,0.00003401209,0.000009745105,0.000007155514,0.1793623,0.0000168421,0.0007250754,0.0002149216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896625,0.001193708,0.000136508,0.00515928,0.002142746,0.001584713,0.000002372937,0.0000876572,0.0000305502],"genre_scores_gemma":[0.9257705,0.0005879517,0.001492181,0.07156754,0.0003151848,0.00003564501,0.00000226275,0.00002977525,0.0001989318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06640827,"threshold_uncertainty_score":0.9999899,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2887655204","doi":"10.1002/cpt.1112","title":"Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance","year":2018,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":229,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"National Institute on Drug Abuse","keywords":"Transporter; Organic anion transporter 1; Organic cation transport proteins; Drug; Pharmacology; Organic anion-transporting polypeptide; Drug development; Disposition; Chemistry; Medicine; Biochemistry; Psychology","authors":[{"name":"Maciej J. Zamek‐Gliszczynski","is_ca":false},{"name":"Mitchell E. Taub","is_ca":false},{"name":"Paresh P. Chothe","is_ca":false},{"name":"Xiaoyan Chu","is_ca":false},{"name":"Kathleen M. Giacomini","is_ca":false},{"name":"Richard B. Kim","is_ca":true},{"name":"Adrian S. Ray","is_ca":false},{"name":"Sophie L. Stocker","is_ca":false},{"name":"Jashvant D. Unadkat","is_ca":false},{"name":"Matthias Wittwer","is_ca":false},{"name":"Cindy Q. Xia","is_ca":false},{"name":"Sook Wah Yee","is_ca":false},{"name":"Lei Zhang","is_ca":false},{"name":"Yan Zhang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2865857439642586,"gpt":0.5248841825983547,"spread":0.2382984386340961,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003443976,0.0007503538,0.004510616,0.000364627,0.0001224835,0.000006596355,0.0006068801,0.001117895,0.0003427922],"category_scores_gemma":[0.00001398962,0.0006314385,0.002208119,0.0005275518,0.0008446322,0.00007695573,0.00001922085,0.001541471,0.00002172737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404802,"about_ca_system_score_gemma":0.001596072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002677566,"about_ca_topic_score_gemma":0.00008931325,"domain_scores_codex":[0.9910448,0.0003980043,0.006344645,0.00113864,0.0002936662,0.0007802387],"domain_scores_gemma":[0.9960716,0.001198618,0.001600406,0.0005515189,0.0002165866,0.00036123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001801172,0.004258974,0.005413321,0.01856233,0.007725084,0.0001709722,0.0009976535,7.860384e-7,0.00001741912,0.00003020003,0.02336469,0.9376574],"study_design_scores_gemma":[0.004724173,0.0003822393,0.0003369344,0.004720698,0.01051003,0.000008637968,0.0001038141,0.00001471675,0.00004556807,0.00004213704,0.9785578,0.0005532753],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002775273,0.9785482,0.002038265,0.002959782,0.008609092,0.004506652,0.0002858896,0.0001183755,0.0001585199],"genre_scores_gemma":[0.0002512931,0.9820894,0.007205413,0.007144687,0.001101477,0.0003124602,0.001048523,0.000172147,0.0006746069],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9551931,"threshold_uncertainty_score":0.9996137,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2138509705","doi":"10.1002/cpt.269","title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>UGT1A1</i> and Atazanavir Prescribing","year":2015,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":221,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Guideline; Atazanavir; Medicine; Pharmacogenetics; Medical physics; Family medicine; Biology; Genotype","authors":[{"name":"RS Gammal","is_ca":false},{"name":"MH Court","is_ca":false},{"name":"Cyrine E. Haidar","is_ca":false},{"name":"OF Iwuchukwu","is_ca":false},{"name":"Aditya H. Gaur","is_ca":false},{"name":"Maria L. Alvarellos","is_ca":false},{"name":"Chantal Guillemette","is_ca":true},{"name":"JL Lennox","is_ca":false},{"name":"Michelle Whirl‐Carrillo","is_ca":false},{"name":"SS Brummel","is_ca":false},{"name":"MJ Ratain","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"BR Schackman","is_ca":false},{"name":"KE Caudle","is_ca":false},{"name":"DW Haas","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2694700399285668,"gpt":0.5659185183564023,"spread":0.2964484784278355,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002336774,0.000254484,0.000618446,0.00003917369,0.0001077978,0.00001433439,0.0001672964,0.0003612565,0.00009446642],"category_scores_gemma":[0.00008161125,0.0002256867,0.0002171854,0.0001030149,0.0005259322,0.00005218442,0.0001241054,0.0006000765,0.00001777625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005160041,"about_ca_system_score_gemma":0.0006570406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000715745,"about_ca_topic_score_gemma":0.000003225706,"domain_scores_codex":[0.9965094,0.0002524225,0.001906771,0.0005819958,0.0002220154,0.0005273696],"domain_scores_gemma":[0.9972306,0.0007398082,0.0003698424,0.0002489087,0.000512646,0.0008982183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00829292,0.001597605,0.2196395,0.000362666,0.001333745,0.00007262405,0.0001178754,0.000005860597,0.02405393,0.00001591323,0.4633981,0.2811093],"study_design_scores_gemma":[0.02450307,0.002674886,0.004220523,0.00002355012,0.002525817,0.00008813824,0.0002535168,0.003216221,0.02128581,0.000174813,0.940706,0.0003276587],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600416,0.005376136,0.001883455,0.02622004,0.003692412,0.002251775,0.0001846946,0.0001351428,0.0002147741],"genre_scores_gemma":[0.6012204,0.006418372,0.01849589,0.367194,0.005472811,0.0001457997,0.0004929195,0.00008744331,0.0004723683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4773079,"threshold_uncertainty_score":0.9203238,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2048099302","doi":"10.1016/j.clpt.2006.08.011","title":"CYP2A6 genotype and the metabolism and disposition kinetics of nicotine","year":2006,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Center for Research Resources; National Institute on Drug Abuse","keywords":"CYP2A6; Cotinine; Nicotine; Metabolism; Pharmacology; Endocrinology; Internal medicine; Chemistry; Medicine; Cytochrome P450; CYP1A2","authors":[{"name":"Neal L. Benowitz","is_ca":true},{"name":"Gary E. Swan","is_ca":true},{"name":"P JACOBIII","is_ca":true},{"name":"Christina N. Lessov‐Schlaggar","is_ca":true},{"name":"Rachel F. Tyndale","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01663948883646598,"gpt":0.3375414490556897,"spread":0.3209019602192237,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005027776,0.0001662566,0.0003366333,0.00002017275,0.00006224583,0.000009064716,0.0001710192,0.0002095424,0.0000168623],"category_scores_gemma":[0.0000219167,0.0001165473,0.0001053981,0.00006887681,0.001163106,0.00000283763,0.0002061443,0.0002249667,0.000002369831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003742222,"about_ca_system_score_gemma":0.00002285578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001019052,"about_ca_topic_score_gemma":0.000008724882,"domain_scores_codex":[0.9984823,0.0003895682,0.0005319652,0.0003052584,0.00009031571,0.0002006228],"domain_scores_gemma":[0.9991746,0.0002383818,0.0002177013,0.000212046,0.000104016,0.0000532745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001445606,0.0006741932,0.01159788,0.0000198421,0.0006738534,3.581074e-7,0.00005663123,0.00002386495,0.9743708,0.0003933975,0.005620012,0.005123594],"study_design_scores_gemma":[0.02014745,0.001256622,0.06153192,0.0000105555,0.002879826,0.00004105107,0.00006669163,0.0006547491,0.6689165,0.0009719214,0.2430001,0.0005226895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849606,0.009825834,0.0006453613,0.003400916,0.0005627551,0.0003513574,0.0000146793,0.00001101506,0.0002275239],"genre_scores_gemma":[0.9870685,0.004574254,0.0005851739,0.006568904,0.00091722,0.0000133383,0.00002794034,0.00002392181,0.0002206962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3054543,"threshold_uncertainty_score":0.4752661,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2077136462","doi":"10.1067/mcp.2001.113185","title":"Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins","year":2001,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":208,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"American Association of Pharmaceutical Scientists; U.S. Public Health Service; Medical Research Council Canada; National Center for Research Resources; National Institute of General Medical Sciences; Medical Research Council; University of Washington","keywords":"Grapefruit juice; Chemistry; Felodipine; Orange juice; Furocoumarins; Orange (colour); Food science; Citrus paradisi; Pharmacokinetics; Metabolite; Pharmacology; Chromatography; Biochemistry; Rutaceae; Botany; Medicine; Endocrinology","authors":[{"name":"Sanjay V. Malhotra","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3144994907808211,"gpt":0.5280572764054656,"spread":0.2135577856246445,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001435168,0.0005932592,0.001160017,0.0002238134,0.0003440746,0.00002963556,0.0006088814,0.0005787189,0.002124742],"category_scores_gemma":[0.00001714054,0.0005113449,0.0002529256,0.0005437453,0.001280154,0.0001850901,0.0003318286,0.001939417,0.0001094051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006132498,"about_ca_system_score_gemma":0.0001757321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002164632,"about_ca_topic_score_gemma":0.00005023402,"domain_scores_codex":[0.9951923,0.001260406,0.001564339,0.0008161742,0.0003422033,0.0008246079],"domain_scores_gemma":[0.9965116,0.001324972,0.000775669,0.0003925277,0.0003977115,0.0005975186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01687385,0.01219167,0.55759,0.000399636,0.01174041,0.0003085734,0.003017222,0.001818555,0.1135743,0.000442251,0.05805375,0.2239898],"study_design_scores_gemma":[0.01022277,0.001202764,0.01632838,0.00002596226,0.003608816,0.00007623861,0.0003204741,0.005261133,0.01915921,0.0001344418,0.9430441,0.0006157596],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975175,0.007205741,0.0004346518,0.007320546,0.005434549,0.001124782,0.00005615264,0.0001515755,0.003097036],"genre_scores_gemma":[0.9294834,0.02005909,0.000764364,0.04755722,0.001152549,0.0001152915,0.00004345909,0.00008294847,0.0007416434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8849903,"threshold_uncertainty_score":0.9997338,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2917080169","doi":"10.1002/cpt.1409","title":"Clinical Pharmacogenetics Implementation Consortium Guideline for <scp>Cytochrome P450 (<i>CYP</i>)</scp><i>2D6</i> Genotype and Atomoxetine Therapy","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institutes of Health","keywords":"Atomoxetine; CYP2D6; Pharmacogenetics; Pharmacology; Medicine; Cytochrome P450; Guideline; Genotype; Atomoxetine hydrochloride; Pharmacokinetics; Attention deficit hyperactivity disorder; Internal medicine; Psychiatry; Metabolism; Biology; Genetics; Methylphenidate","authors":[{"name":"Jacob T. Brown","is_ca":false},{"name":"Jeffrey R. Bishop","is_ca":false},{"name":"Katrin Sangkuhl","is_ca":false},{"name":"Erika L. Nurmi","is_ca":false},{"name":"Daniel J. Müller","is_ca":true},{"name":"Jean Dinh","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Kelly E. Caudle","is_ca":false},{"name":"James T. McCracken","is_ca":false},{"name":"José de León","is_ca":false},{"name":"J. Steven Leeder","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1334353888882253,"gpt":0.5070233472240556,"spread":0.3735879583358304,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002400078,0.0005077586,0.001242388,0.0001368479,0.0001730488,0.00003818264,0.0002802267,0.0005588317,0.0009312397],"category_scores_gemma":[0.0001202872,0.0004662758,0.0005715991,0.0002672036,0.0005826023,0.0001344258,0.000154799,0.0009734983,0.0002650862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005571408,"about_ca_system_score_gemma":0.0004257417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000440039,"about_ca_topic_score_gemma":0.000003649349,"domain_scores_codex":[0.9946615,0.0006547997,0.002484382,0.001044982,0.0003824852,0.0007718804],"domain_scores_gemma":[0.9941061,0.003355851,0.0007902987,0.0005123476,0.0007734157,0.0004620533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002233471,0.00347269,0.5576475,0.000149825,0.004141004,0.00003483852,0.0002033307,0.00002411282,0.3129159,0.0000400406,0.07095131,0.04818594],"study_design_scores_gemma":[0.03789001,0.003890631,0.1213659,0.00001966784,0.002951332,0.00008734428,0.0005441033,0.003248774,0.00554139,0.0001204439,0.8240077,0.0003326754],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788212,0.003196733,0.00197147,0.009591698,0.002245107,0.003675547,0.0001085075,0.0001854689,0.0002042589],"genre_scores_gemma":[0.7883943,0.01367939,0.00598271,0.1882137,0.001901775,0.0001655823,0.000308331,0.000184221,0.001170051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7530564,"threshold_uncertainty_score":0.9999821,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2008228624","doi":"10.1038/clpt.2008.29","title":"Integrating Family Medicine and Pharmacy to Advance Primary Care Therapeutics","year":2008,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmaceutical Practices and Patient Outcomes","field":"Medicine","cited_by":195,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; St. Joseph’s Healthcare Hamilton; University of British Columbia; University of Ottawa; McMaster University; Child and Family Research Institute","funders":"","keywords":"Medicine; Multidisciplinary approach; Pharmacist; Pharmacy; Medical home; Clinical pharmacy; Family medicine; Health care; MEDLINE; Primary care; Nursing","authors":[{"name":"Kevin Pottie","is_ca":true},{"name":"Janusz Kaczorowski","is_ca":true},{"name":"Barbara Farrell","is_ca":true},{"name":"Zubin Austin","is_ca":true},{"name":"Carlos Rodrı́guez","is_ca":true},{"name":"Kathryn Gaebel","is_ca":true},{"name":"C. Paul Sellors","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.5029480220296687,"gpt":0.5943371294147648,"spread":0.09138910738509609,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000655518,0.00120584,0.004654192,0.0003535491,0.0003072832,0.00002705803,0.0006225646,0.000741024,0.0001600489],"category_scores_gemma":[0.0001003598,0.0008507381,0.0009317689,0.0006860974,0.001166602,0.0001619017,0.0004168462,0.004016539,0.0001924478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395077,"about_ca_system_score_gemma":0.0009361443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006903126,"about_ca_topic_score_gemma":0.000001188207,"domain_scores_codex":[0.9931888,0.001289852,0.002647233,0.001334247,0.0006065944,0.0009332836],"domain_scores_gemma":[0.9912071,0.005787081,0.0009637665,0.0006671947,0.0003950243,0.0009798205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006550823,0.0004636859,0.0008444326,0.00738877,0.00279078,0.0002321257,0.0005700653,4.528503e-7,0.00006757563,0.000008981222,0.005796077,0.981182],"study_design_scores_gemma":[0.004405715,0.001422832,0.000103776,0.004078767,0.01675971,0.000339028,0.00015391,0.00006625179,0.000005910493,0.00001087354,0.9719198,0.0007334383],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003677337,0.9833978,0.000128814,0.005275979,0.004303915,0.003446972,0.00006892383,0.0002143917,0.002795497],"genre_scores_gemma":[0.00003876721,0.7791573,0.001519249,0.2163893,0.002107182,0.0001358102,0.0001800802,0.0001774239,0.000294916],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9804485,"threshold_uncertainty_score":0.9993944,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1990359955","doi":"10.1038/clpt.2013.45","title":"ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans","year":2013,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Transporter; Pharmacology; Computational biology; Pharmacokinetics; Clinical pharmacology; In vivo; Drug; Computer science; Chemistry; Medicine; Biology; Biochemistry","authors":[{"name":"Maciej J. Zamek‐Gliszczynski","is_ca":false},{"name":"C A Lee","is_ca":false},{"name":"Agnès Poirier","is_ca":false},{"name":"Joe Bentz","is_ca":false},{"name":"Xiaoyan Chu","is_ca":false},{"name":"Harma Ellens","is_ca":false},{"name":"Toshihisa Ishikawa","is_ca":false},{"name":"Masoud Jamei","is_ca":false},{"name":"J. Cory Kalvass","is_ca":false},{"name":"Swati Nagar","is_ca":false},{"name":"K. Sandy Pang","is_ca":true},{"name":"Ken Korzekwa","is_ca":false},{"name":"Peter W. Swaan","is_ca":false},{"name":"Mitchell E. Taub","is_ca":false},{"name":"Ping Zhao","is_ca":false},{"name":"Aleksandra Galetin","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2338386338342339,"gpt":0.4729230737368746,"spread":0.2390844399026406,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005225646,0.0003772748,0.001855387,0.0002273412,0.00005379268,0.000005710367,0.0001034452,0.0006604992,0.0001552419],"category_scores_gemma":[0.000006459336,0.0003042928,0.0004289908,0.0001612435,0.0002787774,0.00006775388,0.000004276349,0.0006439373,0.000002038095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001687809,"about_ca_system_score_gemma":0.0001811902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000430549,"about_ca_topic_score_gemma":0.00001653214,"domain_scores_codex":[0.9970697,0.0001365659,0.001865933,0.0005045899,0.0001361835,0.0002870955],"domain_scores_gemma":[0.9983031,0.0009732361,0.0003172179,0.0001547614,0.0001036443,0.0001480287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007827624,0.001763029,0.001445623,0.02290623,0.002725169,0.00002428687,0.0009691528,0.0001636949,0.0001235243,0.0001342444,0.0002587914,0.9687035],"study_design_scores_gemma":[0.01780238,0.001464005,0.001831063,0.009534524,0.04557187,0.0000335294,0.00009736847,0.1269509,0.00002189718,0.002558989,0.7926863,0.00144715],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007771313,0.9554494,0.02824301,0.003187165,0.0006574416,0.004189931,0.0004287163,0.00004845245,0.00002458471],"genre_scores_gemma":[0.007075356,0.979138,0.01027263,0.001599715,0.0001185846,0.0003203945,0.001348516,0.00006869876,0.00005811885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9672564,"threshold_uncertainty_score":0.9999409,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2069218640","doi":"10.1038/clpt.2011.66","title":"The Human Placental Perfusion Model: A Systematic Review and Development of a Model to Predict In Vivo Transfer of Therapeutic Drugs","year":2011,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Perfusion; In vivo; Pharmacokinetics; Placenta; Fetus; Drug; Pharmacology; Medicine; Pregnancy; Internal medicine; Biology; Biotechnology","authors":[{"name":"J.R. Hutson","is_ca":true},{"name":"Ashley E. Davis","is_ca":true},{"name":"Gideon Koren","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2179108919265466,"gpt":0.4587818482045433,"spread":0.2408709562779966,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002150175,0.0005111143,0.004548568,0.0001260552,0.0001364048,0.000003676558,0.0004592944,0.0004306813,0.0000229977],"category_scores_gemma":[0.00002217397,0.0002992367,0.0005247696,0.0002047574,0.0004916454,0.00002702136,0.0001954282,0.0008499102,0.000003540518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007985721,"about_ca_system_score_gemma":0.0006151306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001022765,"about_ca_topic_score_gemma":0.000006100006,"domain_scores_codex":[0.9949386,0.0008743416,0.003087028,0.0004776995,0.0002501252,0.0003722224],"domain_scores_gemma":[0.9977579,0.00101777,0.0004919175,0.0004673839,0.0001215251,0.0001435592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002993548,0.001030687,0.00005506821,0.9246578,0.004438956,0.000004431783,0.003959226,0.00000625755,0.00005914851,0.0000812178,0.0002675277,0.06514033],"study_design_scores_gemma":[0.004727549,0.001227611,0.00002888222,0.838373,0.08233307,0.00004911851,0.0001902664,0.002269539,0.0001148547,0.0001830925,0.06954811,0.0009549225],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003952527,0.9927565,0.0003105491,0.0002274447,0.0001395565,0.00592314,0.00003677378,0.00002320451,0.0001875957],"genre_scores_gemma":[0.001442035,0.9930324,0.0003008977,0.00432331,0.00002882724,0.0006588751,0.000007409149,0.00005792145,0.0001483126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0862848,"threshold_uncertainty_score":0.999946,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2065390851","doi":"10.1038/clpt.2010.355","title":"A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity","year":2011,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":191,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Idiosyncrasy; Isoniazid; Metabolite; Clinical pharmacology; Mechanism (biology); Pharmacology; Medicine; Internal medicine; Tuberculosis; Pathology; Economics; Epistemology","authors":[{"name":"I G Metushi","is_ca":true},{"name":"Ping Cai","is_ca":true},{"name":"Xu Zhu","is_ca":true},{"name":"Takeshi Nakagawa","is_ca":true},{"name":"J P Uetrecht","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.5197160465884401,"gpt":0.5517765724236009,"spread":0.03206052583516084,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.005787132,0.001468329,0.004192376,0.0003476595,0.0009909209,0.00002859749,0.00240274,0.005455632,0.006254684],"category_scores_gemma":[0.0001115177,0.001078041,0.002667365,0.0008518269,0.001850503,0.0001413912,0.001110279,0.00863548,0.001899669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000489539,"about_ca_system_score_gemma":0.001092109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004711514,"about_ca_topic_score_gemma":0.00008083672,"domain_scores_codex":[0.9830058,0.009948041,0.003664247,0.001511637,0.0004228489,0.001447479],"domain_scores_gemma":[0.9892907,0.005544307,0.002938721,0.001252232,0.0003635035,0.0006106078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009693949,0.003258645,0.0001527194,0.004660973,0.0105841,0.0001083549,0.0006669037,0.000003703311,0.002329748,0.001058921,0.01798955,0.958217],"study_design_scores_gemma":[0.001930975,0.0007659889,0.00001036772,0.0004986608,0.01321607,0.0001315752,0.00003177711,0.0001547098,0.007498146,0.0009120743,0.9738602,0.0009894702],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006453657,0.9642475,0.0001168648,0.0008202919,0.01848808,0.00574621,0.0005223229,0.0003414178,0.003263694],"genre_scores_gemma":[0.002099667,0.9703022,0.00006842791,0.02278323,0.002072413,0.0008228054,0.00008254528,0.0002404174,0.001528322],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9572275,"threshold_uncertainty_score":0.9998066,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1965717563","doi":"10.1002/cpt.59","title":"From adaptive licensing to adaptive pathways: Delivering a flexible life‐span approach to bring new drugs to patients","year":2015,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":187,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institut National d'Excellence en Santé et en Services Sociaux; Canadian Agency for Drugs and Technologies in Health; Health Canada","funders":"European Federation of Pharmaceutical Industries and Associations","keywords":"Risk analysis (engineering); Sustainability; Business; Drug development; Life span; Adaptive strategies; New product development; Medicine; Drug; Marketing; Gerontology; Pharmacology","authors":[{"name":"H‐G Eichler","is_ca":false},{"name":"LG Baird","is_ca":false},{"name":"Richard Barker","is_ca":false},{"name":"Brigitte Bloechl‐Daum","is_ca":false},{"name":"Finn Børlum Kristensen","is_ca":false},{"name":"Jeffrey S. Brown","is_ca":false},{"name":"Rachel Chua","is_ca":false},{"name":"Susanna Del Signore","is_ca":false},{"name":"Ute Dugan","is_ca":false},{"name":"John Ferguson","is_ca":false},{"name":"S Garner","is_ca":false},{"name":"Wim Goettsch","is_ca":false},{"name":"Jeremy R.M. Haigh","is_ca":false},{"name":"Peter K. Honig","is_ca":false},{"name":"Anton Hoos","is_ca":false},{"name":"P Huckle","is_ca":false},{"name":"Tatsuya Kondo","is_ca":false},{"name":"Yann Le Cam","is_ca":false},{"name":"Hubert G. M. Leufkens","is_ca":false},{"name":"Robyn Lim","is_ca":true},{"name":"Carole Longson","is_ca":false},{"name":"Murray Lumpkin","is_ca":false},{"name":"John M. Maraganore","is_ca":false},{"name":"Brian O’Rourke","is_ca":true},{"name":"Kenneth A. Oye","is_ca":false},{"name":"Edmund J. Pezalla","is_ca":false},{"name":"Francesco Pignatti","is_ca":false},{"name":"June Raine","is_ca":false},{"name":"Guido Rasi","is_ca":false},{"name":"Tomas Salmonson","is_ca":false},{"name":"Dima Samaha","is_ca":true},{"name":"Sebastian Schneeweiß","is_ca":false},{"name":"PD Siviero","is_ca":false},{"name":"Matthew Skinner","is_ca":false},{"name":"J. Russell Teagarden","is_ca":false},{"name":"Toshiyoshi Tominaga","is_ca":false},{"name":"MR Trusheim","is_ca":false},{"name":"Sean Tunis","is_ca":false},{"name":"T F Unger","is_ca":false},{"name":"Spiros Vamvakas","is_ca":false},{"name":"Gigi Hirsch","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.696669527203476,"gpt":0.5022952081605061,"spread":0.1943743190429699,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006724103,0.000403071,0.001517063,0.0003661944,0.0001695957,0.00008837734,0.0006936673,0.0003392685,0.0001012626],"category_scores_gemma":[0.001067087,0.0005201814,0.0002174058,0.0004667809,0.00008433702,0.0003083477,0.0004171817,0.000559114,0.006494322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009005607,"about_ca_system_score_gemma":0.0005779593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001866378,"about_ca_topic_score_gemma":0.00004172394,"domain_scores_codex":[0.9929453,0.0007391447,0.00399199,0.00128713,0.0001859843,0.0008505005],"domain_scores_gemma":[0.9940641,0.001779321,0.001123616,0.0005508096,0.0003013597,0.002180782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00488686,0.005022421,0.1016945,0.0001089944,0.004277819,0.000008471131,0.1491459,0.05829643,0.0001548703,0.003512714,0.6548702,0.01802076],"study_design_scores_gemma":[0.02048642,0.007213623,0.101101,0.0003989251,0.0006880657,0.000003693475,0.01770869,0.1622939,0.0003316758,0.01089768,0.6743221,0.00455422],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8826619,0.0006083203,0.07786708,0.0293936,0.003983655,0.002324432,0.0002986122,0.000180688,0.002681758],"genre_scores_gemma":[0.4670367,0.00006231158,0.06564954,0.4633859,0.003294712,0.00009128523,0.00003293877,0.0001158519,0.000330725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4339923,"threshold_uncertainty_score":0.999725,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2064401742","doi":"10.1016/j.clpt.2004.10.005","title":"Effect of Grapefruit Juice Volume on the Reduction of Fexofenadine Bioavailability: Possible Role of Organic Anion Transporting Polypeptides*","year":2005,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University; Lawson Health Research Institute; London Health Sciences Centre","funders":"National Institute of General Medical Sciences","keywords":"Grapefruit juice; Fexofenadine; Chemistry; Bioavailability; Pharmacokinetics; Terfenadine; Crossover study; Pharmacology; Volume (thermodynamics); Volume of distribution; Food science; Chromatography; Medicine","authors":[{"name":"George K. Dresser","is_ca":true},{"name":"Richard B. Kim","is_ca":true},{"name":"David G. Bailey","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03041097844041151,"gpt":0.359090940454376,"spread":0.3286799620139644,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001967615,0.0002186886,0.0008116789,0.00009863338,0.00006300694,0.000001900844,0.0002227026,0.0002719151,0.0005077744],"category_scores_gemma":[0.00002740268,0.0001424884,0.0004046447,0.0003873022,0.0006744878,0.00004380032,0.00001360304,0.000529424,0.0000137892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003792904,"about_ca_system_score_gemma":0.000114978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007590663,"about_ca_topic_score_gemma":0.00000999122,"domain_scores_codex":[0.9974695,0.0003640746,0.001287107,0.0003189977,0.0002803276,0.0002799476],"domain_scores_gemma":[0.9982139,0.0005767046,0.0005951353,0.0003176834,0.0001944059,0.0001021905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003949267,0.00110151,0.02974283,0.0002239903,0.0005905268,0.000002622516,0.000319726,0.0000175266,0.9473433,0.00003773388,0.000136499,0.01653449],"study_design_scores_gemma":[0.003033397,0.004462003,0.01847787,0.0001221821,0.002332317,0.000008844459,0.0001437386,0.0002923085,0.9679196,0.00009067705,0.002991411,0.0001256927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930869,0.0008391165,0.00006012797,0.004522521,0.00047111,0.000738886,0.00001530594,0.00003925154,0.0002267883],"genre_scores_gemma":[0.9970354,0.0006353304,0.0002047099,0.001440684,0.0003248652,0.00001068638,0.00001201332,0.00003539772,0.0003008599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02057629,"threshold_uncertainty_score":0.5810508,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2011711268","doi":"10.1038/clpt.2008.57","title":"Toward Personalized Therapy for Smoking Cessation: A Randomized Placebo-controlled Trial of Bupropion","year":2008,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Cancer Institute; National Institute on Drug Abuse","keywords":"Bupropion; Placebo; Smoking cessation; Medicine; Quartile; Cotinine; Randomized controlled trial; Internal medicine; Clinical trial; Pharmacology; Nicotine; Anesthesia; Alternative medicine; Confidence interval","authors":[{"name":"Freda Patterson","is_ca":false},{"name":"R A Schnoll","is_ca":false},{"name":"EP Wileyto","is_ca":false},{"name":"António Pinto","is_ca":false},{"name":"LH Epstein","is_ca":false},{"name":"P G Shields","is_ca":false},{"name":"Larry W. Hawk","is_ca":false},{"name":"Rachel F. Tyndale","is_ca":true},{"name":"Neal L. Benowitz","is_ca":false},{"name":"Caryn Lerman","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1958475682510731,"gpt":0.4507949521844458,"spread":0.2549473839333727,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002298825,0.0002311876,0.001667484,0.0001118287,0.0001395777,0.000006648968,0.000145743,0.0003950723,0.0003630417],"category_scores_gemma":[0.0001576556,0.0001689582,0.001053229,0.0001421397,0.0007885055,0.00005473585,0.00001719193,0.0004012321,0.000001587228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005356906,"about_ca_system_score_gemma":0.0003317123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003369873,"about_ca_topic_score_gemma":1.005129e-7,"domain_scores_codex":[0.9969205,0.0008092694,0.00129871,0.0003493078,0.000354935,0.0002672481],"domain_scores_gemma":[0.9955099,0.0031772,0.0006111033,0.0001983605,0.0003988465,0.0001046382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9861062,0.001582045,0.003310186,0.00002253265,0.001809128,0.000008775147,0.0007382315,0.000003526115,0.002135512,0.00004099888,0.000903423,0.003339401],"study_design_scores_gemma":[0.9848545,0.002142654,0.00155677,0.00001900452,0.002828443,0.00001923823,0.0000574231,0.0006960729,0.002870951,0.0001752385,0.004623244,0.0001564996],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811721,0.0005204162,0.002410435,0.005076485,0.003154744,0.007377422,0.00000610714,0.00008810421,0.0001941828],"genre_scores_gemma":[0.9804503,0.004625328,0.0003358773,0.0116693,0.001331055,0.001145924,0.00004024344,0.00003871733,0.0003632696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00659282,"threshold_uncertainty_score":0.6889917,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2166210552","doi":"10.1002/cpt.280","title":"Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting","year":2015,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":180,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; National Institute on Drug Abuse; Wellcome Trust","keywords":"Workgroup; Standardization; Confusion; Pharmacogenetics; Nomenclature; Chemical nomenclature; Transparency (behavior); Computer science; Computational biology; Medicine; Biology; Genetics; Psychology; Gene; Taxonomy (biology); Genotype","authors":[{"name":"LV Kalman","is_ca":false},{"name":"Malin Lindqvist Appell","is_ca":false},{"name":"J.H. Black","is_ca":false},{"name":"GC Bell","is_ca":false},{"name":"Sotiria Boukouvala","is_ca":false},{"name":"Carsten Bruckner","is_ca":false},{"name":"Elspeth A. Bruford","is_ca":false},{"name":"KE Caudle","is_ca":false},{"name":"SA Coulthard","is_ca":false},{"name":"Ann K. Daly","is_ca":false},{"name":"AL Del Tredici","is_ca":false},{"name":"Johan T. den Dunnen","is_ca":false},{"name":"Katarzyna Drozda","is_ca":false},{"name":"Robin E. Everts","is_ca":false},{"name":"David A. Flockhart","is_ca":false},{"name":"Robert R. Freimuth","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false},{"name":"Houda Hachad","is_ca":false},{"name":"Toinette Hartshorne","is_ca":false},{"name":"Magnus Ingelman‐Sundberg","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"Volker M. Lauschke","is_ca":false},{"name":"DR Maglott","is_ca":false},{"name":"HL McLeod","is_ca":false},{"name":"GA McMillin","is_ca":false},{"name":"Meyer Ua","is_ca":false},{"name":"Müller Dj","is_ca":true},{"name":"D. A. Nickerson","is_ca":false},{"name":"WS Oetting","is_ca":false},{"name":"MA Pacanowski","is_ca":false},{"name":"Pratt Vm","is_ca":false},{"name":"MV Relling","is_ca":false},{"name":"Angharad M. Roberts","is_ca":false},{"name":"Rubinstein Ws","is_ca":false},{"name":"Katrin Sangkuhl","is_ca":false},{"name":"Matthias Schwab","is_ca":false},{"name":"Stuart A. Scott","is_ca":false},{"name":"SC Sim","is_ca":false},{"name":"RK Thirumaran","is_ca":false},{"name":"LH Toji","is_ca":false},{"name":"Rachel F. Tyndale","is_ca":true},{"name":"RHN van Schaik","is_ca":false},{"name":"Michelle Whirl‐Carrillo","is_ca":false},{"name":"K. L. B. Yeo","is_ca":false},{"name":"UM Zanger","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.7130136977464977,"gpt":0.6624251810135845,"spread":0.0505885167329132,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.009809626,0.001608663,0.004249827,0.0005695795,0.0006781565,0.0001297438,0.002678433,0.00300353,0.002340173],"category_scores_gemma":[0.0007784889,0.001500064,0.002384553,0.0008527177,0.0008958586,0.0001861379,0.0008098893,0.005749726,0.0005914902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004549016,"about_ca_system_score_gemma":0.001860544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002050206,"about_ca_topic_score_gemma":0.000002251573,"domain_scores_codex":[0.9849439,0.002802541,0.007855088,0.002079278,0.0005627231,0.001756488],"domain_scores_gemma":[0.9821507,0.00733676,0.007162268,0.0008375485,0.001193775,0.001318978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000267554,0.00158394,0.00006952116,0.0007152391,0.004761472,0.00006612197,0.0001173798,0.00002095285,0.0001504468,0.0000189833,0.3473572,0.6448712],"study_design_scores_gemma":[0.005643948,0.0003288791,0.00000481112,0.0003122217,0.02015956,0.0001345688,0.00003092187,0.001098164,0.0001186849,0.0004065745,0.9703646,0.001397056],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004957153,0.9426365,0.0003242099,0.008199697,0.03971567,0.004230896,0.002313699,0.0003710301,0.002158702],"genre_scores_gemma":[0.00002306427,0.9280226,0.003518204,0.04892081,0.01167749,0.001614417,0.002444393,0.0003642593,0.00341477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6434742,"threshold_uncertainty_score":0.9996661,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1586266234","doi":"10.1002/cpt.176","title":"Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group","year":2015,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; Indiana Clinical and Translational Sciences Institute; National Institute of Environmental Health Sciences; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Transporter; Ontogeny; Drug; Pharmacology; Medicine; Computational biology; Chemistry; Biology; Biochemistry; Internal medicine; Gene","authors":[{"name":"Kim L. R. Brouwer","is_ca":false},{"name":"Lauren M. Aleksunes","is_ca":false},{"name":"Barbara Brandys","is_ca":false},{"name":"Giacoia Gp","is_ca":false},{"name":"Gregory T. Knipp","is_ca":false},{"name":"Bernd Meibohm","is_ca":false},{"name":"Nigam Sk","is_ca":false},{"name":"Michael Rieder","is_ca":true},{"name":"Saskia N. de Wildt","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1933324047875961,"gpt":0.47056720107202,"spread":0.2772347962844239,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001717317,0.0004555099,0.003522022,0.0001206658,0.00008015101,0.000002923683,0.0004616905,0.000500945,0.0001543777],"category_scores_gemma":[0.000004763165,0.000284426,0.001355202,0.0003926494,0.0005061993,0.00003166791,0.00002728384,0.001227841,0.000002813302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004059276,"about_ca_system_score_gemma":0.0003915413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002528913,"about_ca_topic_score_gemma":0.00001350408,"domain_scores_codex":[0.9957038,0.0005016091,0.002710631,0.0004894098,0.0002863474,0.0003082119],"domain_scores_gemma":[0.9974827,0.0002512309,0.001329693,0.0005188184,0.0002195947,0.0001979572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001884715,0.003321379,0.006115649,0.1811085,0.007241677,0.00005360745,0.0007003651,1.880742e-7,0.00003979046,0.0001037284,0.01951582,0.7816108],"study_design_scores_gemma":[0.001424971,0.0001864156,0.0004255752,0.01010257,0.0799847,0.00001466939,0.00002069683,3.088941e-7,0.000003646346,0.0000453893,0.9075509,0.0002401256],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002855292,0.9936748,0.00002704143,0.001928927,0.001668251,0.002131326,0.00009961425,0.00002938641,0.0001551139],"genre_scores_gemma":[0.0004174612,0.9923501,0.0002348299,0.005754176,0.0005124675,0.00006667985,0.0001165431,0.00007455448,0.0004731872],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8880351,"threshold_uncertainty_score":0.9999608,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1987867942","doi":"10.1067/mcp.2000.107651","title":"Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking","year":2000,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre for Addiction and Mental Health; Coalition for Research in Women's Health","funders":"National Institute on Drug Abuse","keywords":"Nicotine; CYP2A6; Pharmacology; Placebo; Bioavailability; Crossover study; Methoxsalen; Nicotine patch; Cmax; Oral administration; Medicine; Chemistry; Internal medicine; Metabolism; Cytochrome P450; CYP1A2; Psoriasis; Dermatology","authors":[{"name":"Edward M. Sellers","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09260801774726429,"gpt":0.4211088306776664,"spread":0.3285008129304021,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006744538,0.0001761746,0.0004858772,0.00006979839,0.00008050855,0.000009382204,0.00006844194,0.0002778633,0.002313036],"category_scores_gemma":[0.00004394144,0.0001547725,0.000149372,0.0001795444,0.0007610316,0.00008076506,0.00003517947,0.0003816394,0.000007606999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004502691,"about_ca_system_score_gemma":0.0001134765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004815482,"about_ca_topic_score_gemma":0.000002661958,"domain_scores_codex":[0.9981947,0.0003299903,0.0006964743,0.0003503293,0.000197802,0.0002306923],"domain_scores_gemma":[0.9987122,0.0005939833,0.0001626174,0.0002151495,0.0001418106,0.0001742009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001440638,0.002302631,0.8627179,0.00006482388,0.0003391723,0.00002094568,0.0000907389,0.00000262439,0.0852327,0.00000645165,0.000824808,0.04695662],"study_design_scores_gemma":[0.004453133,0.001004081,0.9435131,0.00005980156,0.002326509,0.00005146702,0.00004639387,0.0001006967,0.04517167,0.0001339459,0.002978035,0.0001611688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977521,0.0003342495,0.00001856432,0.00106762,0.0001625001,0.0003585006,0.00001613045,0.00008491811,0.0002053586],"genre_scores_gemma":[0.9881126,0.001038391,0.0001285969,0.0103006,0.000259382,0.00001627397,0.00004932185,0.00002214468,0.00007270653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08079525,"threshold_uncertainty_score":0.998599,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2937367049","doi":"10.1002/cpt.1477","title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2B6</i> and Efavirenz‐Containing Antiretroviral Therapy","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":179,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"European and Developing Countries Clinical Trials Partnership; National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Minority Health and Health Disparities; Canadian Institutes of Health Research; National Institutes of Health; Partnership for Advanced Computing in Europe AISBL","keywords":"Efavirenz; CYP2B6; Discontinuation; Medicine; Reverse-transcriptase inhibitor; Pharmacogenetics; Adverse effect; Guideline; Pharmacology; Internal medicine; Oncology; Antiretroviral therapy; Human immunodeficiency virus (HIV); Virology; Genotype; Cytochrome P450; Biology; CYP1A2; Viral load; Pathology; Genetics","authors":[{"name":"Zeruesenay Desta","is_ca":false},{"name":"Roseann S. Gammal","is_ca":false},{"name":"Li Gong","is_ca":false},{"name":"Michelle Whirl‐Carrillo","is_ca":false},{"name":"Aditya H. Gaur","is_ca":false},{"name":"Chonlaphat Sukasem","is_ca":false},{"name":"Jennifer Hockings","is_ca":false},{"name":"Alan L. Myers","is_ca":false},{"name":"Marelize Swart","is_ca":false},{"name":"Rachel F. Tyndale","is_ca":true},{"name":"Collen Masimirembwa","is_ca":false},{"name":"Otito F. Iwuchukwu","is_ca":false},{"name":"Sanika Chirwa","is_ca":false},{"name":"Jeffrey L. Lennox","is_ca":false},{"name":"Andrea Gaedigk","is_ca":false},{"name":"Teri E. Klein","is_ca":false},{"name":"David W. Haas","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1044532864015122,"gpt":0.4935270597406963,"spread":0.389073773339184,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001824847,0.0004083237,0.001003545,0.0001054425,0.0001513437,0.00002911838,0.00018379,0.000337789,0.0006193889],"category_scores_gemma":[0.00002051432,0.0003421197,0.0004084534,0.0001502155,0.00037817,0.00008897496,0.000096658,0.0005329038,0.00009644734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006186255,"about_ca_system_score_gemma":0.0003961722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002870243,"about_ca_topic_score_gemma":0.000002259975,"domain_scores_codex":[0.9958913,0.0003817232,0.002085842,0.0007773907,0.0002500097,0.000613689],"domain_scores_gemma":[0.9973482,0.001234825,0.0004750646,0.0002941141,0.0003088244,0.0003389318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003324896,0.0009531879,0.7980566,0.00003579519,0.002562932,0.00002533565,0.000170758,0.000001869904,0.008698415,0.0000254808,0.0305367,0.155608],"study_design_scores_gemma":[0.0554689,0.006739206,0.05325948,0.00003187589,0.00319805,0.00003973983,0.0003601251,0.002454052,0.01005583,0.0001244337,0.867654,0.000614336],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976752,0.002129389,0.0005631167,0.01468244,0.002775147,0.002692999,0.00005044395,0.0001261646,0.0002283306],"genre_scores_gemma":[0.8464287,0.01215326,0.01078644,0.1264201,0.001549793,0.0001388994,0.0003138495,0.0001056692,0.002103296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8371173,"threshold_uncertainty_score":0.9999031,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2027744617","doi":"10.1038/clpt.2010.184","title":"Dipeptidyl Peptidase-4 Inhibitors Administered in Combination With Metformin Result in an Additive Increase in the Plasma Concentration of Active GLP-1","year":2010,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":177,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Metformin; Incretin; Glucagon-like peptide-1; In vivo; Dipeptidyl peptidase; Endocrinology; Internal medicine; Chemistry; Glucagon; Pharmacology; Dipeptidyl peptidase-4; Pharmacokinetics; Small intestine; Type 2 diabetes; Diabetes mellitus; Hormone; Medicine; Biology; Biochemistry; Enzyme","authors":[{"name":"Elizabeth Migoya","is_ca":false},{"name":"Raynald Bergeron","is_ca":true},{"name":"Jutta Miller","is_ca":false},{"name":"Rebekah Snyder","is_ca":false},{"name":"Michael Tanen","is_ca":false},{"name":"D Hilliard","is_ca":false},{"name":"Barry D. Weiss","is_ca":false},{"name":"Patrick Larson","is_ca":false},{"name":"Marie Gutierrez","is_ca":false},{"name":"Guoqiang Jiang","is_ca":false},{"name":"Fang Liu","is_ca":false},{"name":"Kelly Ann D. Pryor","is_ca":false},{"name":"Jun Yao","is_ca":false},{"name":"Lixia Zhu","is_ca":false},{"name":"Jens J. Holst","is_ca":false},{"name":"Carolyn F. Deacon","is_ca":false},{"name":"Gary Herman","is_ca":false},{"name":"Nancy A. Thornberry","is_ca":false},{"name":"John M. Amatruda","is_ca":false},{"name":"Debora Williams‐Herman","is_ca":false},{"name":"John A. Wagner","is_ca":false},{"name":"Ranabir SinhaRoy","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05141449335925543,"gpt":0.39199612142172,"spread":0.3405816280624646,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009297273,0.0001746589,0.0004064188,0.0001562044,0.00002606657,0.000009467488,0.0001518151,0.000187276,0.00005904083],"category_scores_gemma":[0.00004999859,0.0001207625,0.00005955192,0.0003533838,0.0003862527,0.000178402,0.00003115716,0.0006861844,0.000004901671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007537122,"about_ca_system_score_gemma":0.0001395926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003476315,"about_ca_topic_score_gemma":0.0009543792,"domain_scores_codex":[0.9980949,0.0004931544,0.0006585059,0.0002963415,0.0002000644,0.0002570671],"domain_scores_gemma":[0.9984033,0.0009574752,0.0002553667,0.0002030019,0.00009938311,0.00008144679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03152618,0.03347486,0.6669959,0.0001116078,0.001069501,0.0006790124,0.01436673,0.00002967863,0.04540002,0.0007705381,0.001410399,0.2041655],"study_design_scores_gemma":[0.05245744,0.01051995,0.8837592,0.0001642074,0.001139327,0.000008980938,0.003942409,0.003322537,0.03786656,0.0002930265,0.006180514,0.0003458795],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953278,0.00001825151,0.000002217319,0.002084433,0.0002651752,0.001429418,0.00002259335,0.00001458607,0.000835578],"genre_scores_gemma":[0.99483,0.0001096031,0.000200426,0.004389615,0.0001044027,0.0001435999,0.0001691175,0.00001537019,0.00003794019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2167632,"threshold_uncertainty_score":0.4924551,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2101566038","doi":"10.1038/clpt.2009.19","title":"Association of Nicotine Metabolite Ratio and CYP2A6 Genotype With Smoking Cessation Treatment in African-American Light Smokers","year":2009,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institute on Drug Abuse; U.S. Public Health Service","keywords":"CYP2A6; Cotinine; Odds ratio; Nicotine; Confidence interval; Smoking cessation; Genotype; Medicine; Quartile; Internal medicine; Pharmacogenetics; Pharmacology; Physiology; Genetics; Biology; CYP1A2; Cytochrome P450; Pathology; Metabolism","authors":[{"name":"MK Ho","is_ca":true},{"name":"JC Mwenifumbo","is_ca":true},{"name":"Nael Al Koudsi","is_ca":true},{"name":"Okuyemi Ks","is_ca":false},{"name":"JS Ahluwalia","is_ca":false},{"name":"NL Benowitz","is_ca":false},{"name":"Rachel F. Tyndale","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04995220118061289,"gpt":0.3952817783533171,"spread":0.3453295771727042,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005195392,0.0001572076,0.0005018132,0.0001243711,0.00004319007,0.000009009031,0.00005198579,0.0001492681,0.00003531766],"category_scores_gemma":[0.00001746213,0.0001222598,0.00007112879,0.0003359826,0.0001193432,0.00006442344,0.000008223662,0.0002649023,6.159956e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251839,"about_ca_system_score_gemma":0.0001169577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003352962,"about_ca_topic_score_gemma":0.00001561832,"domain_scores_codex":[0.9985251,0.00024391,0.0005351448,0.0002661532,0.0002137918,0.0002159271],"domain_scores_gemma":[0.9989346,0.0002803908,0.0004323519,0.0001325575,0.0001407106,0.00007939229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007704046,0.000835994,0.9512784,0.000006248934,0.000446363,0.000006255145,0.0008011769,0.00002233264,0.01455395,0.00001404305,0.00007496465,0.03118989],"study_design_scores_gemma":[0.0053615,0.002331012,0.9697396,0.00001423701,0.002595265,0.000003978476,0.0001906913,0.0002076376,0.01601804,0.00003735126,0.003381431,0.000119224],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874141,0.0002347212,0.00008696654,0.01143183,0.0002219615,0.0003821157,0.000004540792,0.00003418161,0.0001895627],"genre_scores_gemma":[0.9925587,0.001127355,0.0001666971,0.005796986,0.0001737337,0.00001639207,0.00002685798,0.00001437547,0.0001188619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03107067,"threshold_uncertainty_score":0.498561,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2039185379","doi":"10.1038/clpt.2014.126","title":"Pharmacogenomics of Human Uridine Diphospho-Glucuronosyltransferases and Clinical Implications","year":2014,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":165,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Glucuronidation; Glucuronosyltransferase; Uridine; Pharmacogenomics; Clinical pharmacology; Uridine diphosphate; Pharmacology; Drug metabolism; Xenobiotic; Pharmacogenetics; Drug; Chemistry; Computational biology; Enzyme; Biochemistry; Biology; RNA; Gene; Microsome","authors":[{"name":"Chantal Guillemette","is_ca":true},{"name":"Éric Lévesque","is_ca":true},{"name":"Michèle Rouleau","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2620271041099431,"gpt":0.5475852774856149,"spread":0.2855581733756718,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004062519,0.0006198411,0.001353223,0.000190659,0.0005135266,0.00002667658,0.0009708835,0.0008868364,0.0009349204],"category_scores_gemma":[0.00008103128,0.0006082275,0.000615018,0.000359493,0.002522101,0.0001258622,0.0003278714,0.002162494,0.00009368435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003747086,"about_ca_system_score_gemma":0.000193364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009831851,"about_ca_topic_score_gemma":0.000005899565,"domain_scores_codex":[0.9924076,0.002798474,0.002615548,0.001041703,0.0002220541,0.0009146194],"domain_scores_gemma":[0.9936277,0.003787432,0.0007219385,0.0005569837,0.0003737453,0.0009322325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001407205,0.005522997,0.2538418,0.000136243,0.00373137,0.00001597829,0.0003066809,0.0001606347,0.5292439,0.003529006,0.01647162,0.1856325],"study_design_scores_gemma":[0.01583516,0.001683239,0.07815997,0.00001771047,0.008449194,0.00004160945,0.00004199094,0.004508688,0.1386058,0.003812147,0.7476942,0.001150331],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780274,0.004002979,0.0008536078,0.008466263,0.005459058,0.0009280212,0.0002337232,0.0001818151,0.001847153],"genre_scores_gemma":[0.9189858,0.02222854,0.0005497853,0.05567713,0.002129759,0.00006595726,0.00005959479,0.0001026624,0.0002008167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7312226,"threshold_uncertainty_score":0.9999784,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2031083224","doi":"10.1038/clpt.2013.12","title":"International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Innovation Cluster (Canada)","funders":"National Institute of General Medical Sciences","keywords":"Clinical pharmacology; Transporter; Pharmacodynamics; Pharmacology; Pharmacogenetics; Pharmacokinetics; Allele; Medicine; Biology; Genetics; Computational biology; Gene; Genotype","authors":[{"name":"Kathleen M. Giacomini","is_ca":false},{"name":"Praveen Balimane","is_ca":false},{"name":"Sangeun Cho","is_ca":false},{"name":"Michael T. Eadon","is_ca":false},{"name":"Timi Edeki","is_ca":false},{"name":"Kathleen M. Hillgren","is_ca":false},{"name":"S-M Huang","is_ca":false},{"name":"Yuichi Sugiyama","is_ca":true},{"name":"Dietmar Weitz","is_ca":false},{"name":"Yujia Wen","is_ca":false},{"name":"Chenxi Xia","is_ca":false},{"name":"Sook Wah Yee","is_ca":false},{"name":"Heike Zimdahl","is_ca":false},{"name":"Mikko Niemi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04790878477863259,"gpt":0.3789119958174332,"spread":0.3310032110388006,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007426069,0.0004253052,0.000878093,0.0001245822,0.0001078982,0.00002018543,0.0004287242,0.0004940048,0.009572286],"category_scores_gemma":[0.000004382829,0.0003312402,0.0007427586,0.0001311155,0.0006807852,0.0001118333,0.00001705195,0.001227133,0.0003573334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005828113,"about_ca_system_score_gemma":0.0001270139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001051149,"about_ca_topic_score_gemma":0.000004352644,"domain_scores_codex":[0.9956506,0.0001416308,0.002429944,0.0007140678,0.0004564126,0.0006073097],"domain_scores_gemma":[0.9981021,0.0003630765,0.0003944005,0.0004414938,0.0001949828,0.0005039694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01057228,0.01183,0.6825389,0.00008750612,0.007489491,0.001628953,0.0006221878,0.00001041193,0.0657979,0.000118817,0.1897679,0.02953565],"study_design_scores_gemma":[0.01942972,0.003710736,0.3484405,0.0001308577,0.004146836,0.00006698373,0.0001709598,0.0006926566,0.007829131,0.000612852,0.6138524,0.000916375],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.784346,0.0002319988,0.0009467056,0.2014397,0.007984171,0.001486462,0.00009147201,0.0002582684,0.003215172],"genre_scores_gemma":[0.60926,0.001651996,0.0009571738,0.385588,0.001312472,0.00007518184,0.0001888413,0.00006096376,0.0009053032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4240845,"threshold_uncertainty_score":0.999914,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2112547742","doi":"10.1067/mcp.2000.110774","title":"Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients","year":2000,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":162,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University; London Health Sciences Centre","funders":"","keywords":"Grapefruit juice; Naringin; Felodipine; Naringenin; Chemistry; Pharmacology; Furanocoumarin; Citrus paradisi; CYP3A4; Drug interaction; Pharmacokinetics; Food science; Flavonoid; Rutaceae; Chromatography; Biochemistry; Botany; Cytochrome P450; Medicine; Metabolism; Biology","authors":[{"name":"Damian M. Bailey","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1501635440902356,"gpt":0.5123970513687449,"spread":0.3622335072785093,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001689468,0.0005537613,0.001073875,0.0001719508,0.0003124782,0.000022072,0.0005770852,0.0007239363,0.006467242],"category_scores_gemma":[0.00004262656,0.0004848679,0.0003094284,0.0004718738,0.001178097,0.00020913,0.0001697207,0.001882081,0.000239054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000047413,"about_ca_system_score_gemma":0.0001329354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005740376,"about_ca_topic_score_gemma":0.000002762497,"domain_scores_codex":[0.9950168,0.001903108,0.001251072,0.000782276,0.0002653988,0.0007814002],"domain_scores_gemma":[0.9964247,0.002075949,0.0004650307,0.000292878,0.0002340294,0.0005074193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01484478,0.002681009,0.02745089,0.0003297721,0.004713691,0.0000773471,0.001187013,0.0004908681,0.1317349,0.0000472104,0.01289718,0.8035454],"study_design_scores_gemma":[0.01403802,0.001805278,0.006068921,0.00003434626,0.003941765,0.00005495597,0.00005203203,0.00314443,0.2770573,0.0004003247,0.692766,0.0006366841],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838666,0.003229613,0.00001724843,0.002049632,0.004512829,0.001107774,0.00008760024,0.0001340589,0.004994695],"genre_scores_gemma":[0.9576653,0.01447486,0.0001577506,0.02503709,0.001138735,0.0001419919,0.00003587459,0.00007190485,0.001276506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8029087,"threshold_uncertainty_score":0.9997603,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2116823219","doi":"10.1038/sj.clpt.6100073","title":"The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Centre hospitalier de l'Université Laval; Hôpital de l'Enfant-Jésus","funders":"Hydro-Québec; Canada Research Chairs; Canadian Institutes of Health Research; Université Laval","keywords":"UGT2B7; Mycophenolate; Pharmacokinetics; Mycophenolic acid; Pharmacology; Chemistry; Allele; Medicine; Glucuronidation; Internal medicine; Biochemistry; Enzyme; Gene; Microsome; Transplantation","authors":[{"name":"Éric Lévesque","is_ca":true},{"name":"Robert Delage","is_ca":true},{"name":"Patrick Caron","is_ca":true},{"name":"Olivier Bernard","is_ca":true},{"name":"Félix Couture","is_ca":true},{"name":"Chantal Guillemette","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08041892493863081,"gpt":0.4406712799667477,"spread":0.3602523550281168,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007015101,0.0002245298,0.0004938351,0.0001017673,0.0000663596,0.000006312419,0.0001579656,0.0001377666,0.0002152376],"category_scores_gemma":[0.00001615763,0.0001165504,0.0002478229,0.000262128,0.0006676893,0.00002358924,0.00002878046,0.0004330637,0.0000122792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007196261,"about_ca_system_score_gemma":0.0001320941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004961331,"about_ca_topic_score_gemma":0.00001652884,"domain_scores_codex":[0.9979026,0.0003101691,0.0009158804,0.0002565393,0.0002097558,0.0004050626],"domain_scores_gemma":[0.9978397,0.001430787,0.0002465386,0.0002352678,0.00008826438,0.0001593759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05176546,0.004949601,0.8101614,0.0001659712,0.003154593,0.0002304395,0.001455082,0.00007318638,0.08898369,0.00002497921,0.0002866702,0.03874899],"study_design_scores_gemma":[0.01021604,0.006000756,0.9683341,0.00008730528,0.0008464458,0.00004332624,0.00007067378,0.0004655772,0.01348412,0.00008183403,0.000242663,0.0001271722],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993471,0.002438619,0.00002315682,0.002592979,0.0003458569,0.0009087194,0.00002967039,0.00001288956,0.0001771104],"genre_scores_gemma":[0.9886676,0.002251804,0.0001790995,0.008660126,0.0001069247,0.00003423689,0.000005692738,0.00002732926,0.00006715961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1581728,"threshold_uncertainty_score":0.4752789,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1999064448","doi":"10.1016/s0009-9236(03)00200-5","title":"Folic acid food fortification is associated with a decline in neuroblastoma","year":2003,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"Hospital for Sick Children; Health Sciences Centre; Pediatric Oncology Group; SickKids Foundation; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Hepatoblastoma; Neuroblastoma; Confidence interval; Incidence (geometry); Rate ratio; Pediatrics; Gastroenterology; Internal medicine; Biology","authors":[{"name":"Amy E. French","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1012766599793139,"gpt":0.4183061422281397,"spread":0.3170294822488258,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066437,0.0002523165,0.0006042327,0.0001684686,0.00007455209,0.0000147534,0.0002357198,0.0004006149,0.00030707],"category_scores_gemma":[0.0002914175,0.0002032216,0.0001497145,0.0006878521,0.0004711148,0.00006550685,0.00006688036,0.0009788238,0.00009828182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003600706,"about_ca_system_score_gemma":0.0009320014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002726622,"about_ca_topic_score_gemma":0.00003108562,"domain_scores_codex":[0.9969464,0.0006216015,0.0008571474,0.0005506393,0.0003943363,0.0006298845],"domain_scores_gemma":[0.9975254,0.001313632,0.0002379556,0.0003667761,0.0002753677,0.0002808833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02237779,0.02618094,0.6523309,0.0002537761,0.01251062,0.002166968,0.002214515,0.0001503776,0.1739748,0.0005198556,0.07445878,0.03286068],"study_design_scores_gemma":[0.1355972,0.03192015,0.4386693,0.0003178983,0.006289346,0.00082353,0.0003174418,0.03094531,0.1558497,0.002373887,0.1951324,0.001763922],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821178,0.0002446503,0.0007585634,0.01500331,0.0003887102,0.0008483569,0.00001239435,0.00009803243,0.0005282373],"genre_scores_gemma":[0.8903885,0.0003138138,0.0004742478,0.1082151,0.0001429015,0.00007328094,0.00001876301,0.00005987043,0.0003135504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2136616,"threshold_uncertainty_score":0.8287135,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2036706177","doi":"10.1038/sj.clpt.6100180","title":"Suppression of Niacin-induced Vasodilation with an Antagonist to Prostaglandin D2 Receptor Subtype 1","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Niacin; Medicine; Vasodilation; Antagonist; Pharmacology; Prostaglandin D2; Dyslipidemia; Receptor antagonist; B vitamins; Internal medicine; Endocrinology; Prostaglandin; Receptor","authors":[{"name":"Eseng Lai","is_ca":false},{"name":"Inge De Lepeleire","is_ca":false},{"name":"TM Crumley","is_ca":false},{"name":"Fang Liu","is_ca":false},{"name":"LA Wenning","is_ca":false},{"name":"N. Michiels","is_ca":false},{"name":"Eva Vets","is_ca":false},{"name":"Gary P. O’Neill","is_ca":true},{"name":"JA Wagner","is_ca":false},{"name":"Michael Berkwits","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08715680268425512,"gpt":0.434176956833854,"spread":0.3470201541495989,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001073017,0.000188544,0.0005875472,0.0001151309,0.0000917525,0.000009492945,0.0001481745,0.0002054084,0.0003285116],"category_scores_gemma":[0.00001576905,0.0001406678,0.00009137377,0.0002438381,0.0001532213,0.00006576152,0.00005989741,0.0003315499,0.00005009475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005702097,"about_ca_system_score_gemma":0.0001147829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001754424,"about_ca_topic_score_gemma":0.00002470758,"domain_scores_codex":[0.9981957,0.0001420336,0.0006608217,0.0003883492,0.0002503753,0.0003626873],"domain_scores_gemma":[0.9986814,0.0002644662,0.0002299825,0.0003101797,0.0002108592,0.0003031454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01470207,0.009031468,0.244646,0.0001711213,0.001507917,0.00007742408,0.00142752,0.00002536825,0.6684589,0.0001437708,0.02031897,0.03948943],"study_design_scores_gemma":[0.008139913,0.01610721,0.5946909,0.0001224306,0.002207086,0.0000116855,0.000371599,0.0001672021,0.2688179,0.00004155318,0.1089346,0.0003880466],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914204,0.00005478327,0.0005511979,0.004923393,0.001221375,0.001210762,0.000008995721,0.00006922436,0.0005398396],"genre_scores_gemma":[0.9727867,0.0002387621,0.002149271,0.02397687,0.0005998029,0.00002106436,0.00005199826,0.0000384428,0.0001370894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.399641,"threshold_uncertainty_score":0.5736265,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1989512634","doi":"10.1038/sj.clpt.6100033","title":"Cytochrome P4502D6 (CYP2D6) Gene Locus Heterogeneity: Characterization of Gene Duplication Events","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":149,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute","keywords":"Gene duplication; Gene; Locus (genetics); Genetics; Biology; CYP2D6; Allele; Polymerase chain reaction; Copy-number variation; Genotype; Genome","authors":[{"name":"Andrea Gaedigk","is_ca":false},{"name":"Liliane Ndjountché","is_ca":false},{"name":"Karthika Divakaran","is_ca":false},{"name":"L. DiAnne Bradford","is_ca":false},{"name":"Issam Zineh","is_ca":false},{"name":"Tim F. Oberlander","is_ca":true},{"name":"David C. Brousseau","is_ca":false},{"name":"D. Gail McCarver","is_ca":false},{"name":"J A Johnson","is_ca":false},{"name":"Sarah W. Alander","is_ca":false},{"name":"K. Wayne Riggs","is_ca":true},{"name":"J. Steven Leeder","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2036443214095765,"gpt":0.5107263157474201,"spread":0.3070819943378437,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003972315,0.0005988547,0.001011092,0.0003216594,0.0003174034,0.00001501888,0.0009485458,0.001133346,0.0007958086],"category_scores_gemma":[0.00003714602,0.0006090408,0.0005107335,0.0006419306,0.0007719297,0.0001720249,0.0002372324,0.001496387,0.0002752748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114678,"about_ca_system_score_gemma":0.0002063696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003963173,"about_ca_topic_score_gemma":0.000003532755,"domain_scores_codex":[0.9939475,0.001295233,0.002287769,0.0009243737,0.0004319747,0.001113165],"domain_scores_gemma":[0.9960444,0.0009766412,0.001144094,0.0005746651,0.000570129,0.0006900703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001417257,0.00194122,0.01573317,0.0000434092,0.001491337,0.00003944365,0.0002349121,0.0001022988,0.9382011,0.00003980921,0.0002822969,0.04047377],"study_design_scores_gemma":[0.004978852,0.0003443555,0.0684465,0.000008049766,0.001730597,0.00004334676,0.00001247685,0.001340631,0.8395912,0.0002852678,0.08268771,0.0005310117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798254,0.001622519,0.007991991,0.001752509,0.006736845,0.001250998,0.0002704682,0.0001724557,0.0003767873],"genre_scores_gemma":[0.9484164,0.006690246,0.000880754,0.0409203,0.00233326,0.00007732267,0.0002849539,0.000113008,0.0002838135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09860988,"threshold_uncertainty_score":0.9996361,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2068075375","doi":"10.1016/j.clpt.2003.10.006","title":"A novel functional polymorphism in the uridine diphosphate–glucuronosyltransferase 2B7 promoter with significant impact on promoter activity","year":2004,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":149,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Single-nucleotide polymorphism; UGT2B7; Morphine; Glucuronosyltransferase; Glucuronide; Chemistry; Uridine; Internal medicine; Glucuronidation; Biology; Pharmacology; Genotype; Biochemistry; Medicine; In vitro; Gene; Metabolism; RNA","authors":[{"name":"Yannick Duguay","is_ca":true},{"name":"Cecilie Báár","is_ca":true},{"name":"Frank Skorpen","is_ca":true},{"name":"Chantal Guillemette","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2072944586294889,"gpt":0.4715195295789867,"spread":0.2642250709494978,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002646209,0.000864118,0.0009050973,0.0002375216,0.0004262823,0.00006051456,0.0009559775,0.000732635,0.001284645],"category_scores_gemma":[0.00002169034,0.000539652,0.0005124246,0.0006679143,0.001182658,0.0001949754,0.0001029815,0.003834404,0.0002285641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113576,"about_ca_system_score_gemma":0.0007114146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004130878,"about_ca_topic_score_gemma":0.00001626929,"domain_scores_codex":[0.9943863,0.001597005,0.001045593,0.001097683,0.0005424613,0.001331003],"domain_scores_gemma":[0.9968717,0.001517492,0.0003440339,0.0005455815,0.0001789295,0.0005423204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03437722,0.03695194,0.02064323,0.00008244545,0.005127428,0.001062432,0.002740695,0.0237856,0.8342714,0.0005522209,0.004367909,0.0360375],"study_design_scores_gemma":[0.08228286,0.01043928,0.3039062,0.00009859884,0.00649424,0.0005636374,0.0001603032,0.006339627,0.4347269,0.001835296,0.1500807,0.003072294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648707,0.0006338496,0.001464342,0.02702683,0.003022732,0.002153229,0.0002211213,0.0001258036,0.0004813912],"genre_scores_gemma":[0.9117391,0.0009041033,0.0001901325,0.08521204,0.001398832,0.000313329,0.00004135472,0.00009791082,0.0001031615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3995445,"threshold_uncertainty_score":0.9997055,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3001449808","doi":"10.1002/cpt.1795","title":"Will Artificial Intelligence for Drug Discovery Impact Clinical Pharmacology?","year":2020,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":149,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health","keywords":"Context (archaeology); Drug discovery; Clinical pharmacology; Identification (biology); Clinical trial; Clinical Practice; Generative grammar; Drug; Pharmacology; Medicine; Data science; Artificial intelligence; Computer science; Bioinformatics; Internal medicine; Biology","authors":[{"name":"Alex Zhavoronkov","is_ca":true},{"name":"Quentin Vanhaelen","is_ca":true},{"name":"Tudor I. Oprea","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3585694479664162,"gpt":0.5906098123856323,"spread":0.2320403644192161,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","open_science","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.006156322,0.001342121,0.004995372,0.0003164634,0.0003285934,0.0003925655,0.005443766,0.001192576,0.0001286882],"category_scores_gemma":[0.0003277218,0.001109915,0.005100097,0.001235964,0.00126911,0.00120238,0.001829718,0.003675819,0.0003647393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003697308,"about_ca_system_score_gemma":0.004072073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002087391,"about_ca_topic_score_gemma":0.000001063981,"domain_scores_codex":[0.9828554,0.00722319,0.005385237,0.002707833,0.00056301,0.001265279],"domain_scores_gemma":[0.9613384,0.03441991,0.00212777,0.0009740379,0.000382748,0.0007571086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002320091,0.001171799,0.000007862667,0.0008576261,0.003793251,0.00008888463,0.00006572121,0.0004204863,0.000002440911,0.001450968,0.02800625,0.9639027],"study_design_scores_gemma":[0.0005639051,0.0008491087,0.000008678711,0.0003025689,0.005103443,0.00004410698,0.000006179264,0.05133284,0.00001489175,0.01121913,0.9295155,0.001039633],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002117016,0.5643973,0.4060276,0.005364448,0.02134675,0.002328393,0.0002207407,0.0002678059,0.00002577152],"genre_scores_gemma":[0.00003375351,0.9316645,0.02532444,0.03173237,0.01045389,0.0003969095,0.0001202561,0.0001615891,0.000112249],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9628631,"threshold_uncertainty_score":0.9999372,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}