{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":36,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":36,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"4d53a0d75cf7","filters":{"venue":"Drug Resistance Updates"}},"results":[{"id":"W2171452890","doi":"10.1054/drup.2000.0152","title":"Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment","year":2000,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":519,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Pseudomonas aeruginosa; Antibiotics; Efflux; Antibiotic resistance; Microbiology; Periplasmic space; Biology; Resistance (ecology); Bacterial outer membrane; Bacteria; Genetics; Gene; Ecology; Escherichia coli","authors":[{"name":"Robert E. W. Hancock","is_ca":true},{"name":"David P. Speert","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00525736061795576,"gpt":0.2436045997669158,"spread":0.2383472391489601,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002001156,0.0004601995,0.0004213577,0.00009441363,0.0001270956,0.0000862796,0.0002619149,0.000164994,0.0001604147],"category_scores_gemma":[0.00003446427,0.0003675903,0.0001301822,0.000208221,0.0001824957,0.00001575491,0.00003564546,0.0001115426,0.00005871807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407703,"about_ca_system_score_gemma":0.000079373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004420725,"about_ca_topic_score_gemma":0.001780643,"domain_scores_codex":[0.9978808,0.0001199863,0.000383972,0.0008430018,0.0002077777,0.0005644526],"domain_scores_gemma":[0.9989401,0.00004717878,0.0001095188,0.0007214354,0.00003836411,0.000143426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02242602,0.002998432,0.1479065,0.0006198728,0.0009849104,0.0009222954,0.001671902,0.0004812545,0.7302951,0.01973873,0.05254887,0.01940614],"study_design_scores_gemma":[0.006046035,0.000864101,0.4288797,0.0009170715,0.0001074978,0.00003078594,0.0003907942,0.00004326231,0.4490007,0.007148156,0.1042416,0.002330331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892837,0.002887888,0.00003146947,0.0005005943,0.00007738206,0.0003690494,0.00009000296,0.00003330316,0.006726648],"genre_scores_gemma":[0.9760872,0.003004349,0.002979429,0.0001776331,0.00008868348,0.00001202563,0.0001439903,0.00005368929,0.01745308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2812944,"threshold_uncertainty_score":0.9998776,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2123781894","doi":"10.1016/j.drup.2007.01.003","title":"Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy","year":2007,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":452,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Cell cycle; Programmed cell death; Context (archaeology); Cell biology; Cyclin-dependent kinase; Biology; Cell growth; Apoptosis; Cancer research; Protein kinase B; Regulator; PI3K/AKT/mTOR pathway; Signal transduction; Genetics; Gene","authors":[{"name":"Subbareddy Maddika","is_ca":true},{"name":"Sudharsana Rao Ande","is_ca":true},{"name":"Soumya Panigrahi","is_ca":true},{"name":"Ted Paranjothy","is_ca":true},{"name":"Kazimierz Węglarczyk","is_ca":true},{"name":"Anne Zuse","is_ca":true},{"name":"Mohsen Eshraghi","is_ca":true},{"name":"Kailash Manda","is_ca":true},{"name":"Emilia Wiecheć","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05591776088849937,"gpt":0.3349819565211766,"spread":0.2790641956326773,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004183476,0.0009168238,0.002197866,0.0003704233,0.0002624114,0.00009749508,0.0004502092,0.0005734694,0.00009167705],"category_scores_gemma":[0.00004955131,0.0008025386,0.000697555,0.0005768657,0.0001331294,0.00009197433,0.0001070194,0.0007529375,0.00003689004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236695,"about_ca_system_score_gemma":0.0006898504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008107277,"about_ca_topic_score_gemma":0.0005228571,"domain_scores_codex":[0.9964386,0.0001309613,0.001003565,0.001292008,0.0003048367,0.0008300456],"domain_scores_gemma":[0.9965687,0.0005373689,0.0008947719,0.001255009,0.000372112,0.0003720471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001003741,0.002252145,0.0004689355,0.140567,0.001278531,0.0001995646,0.00143045,0.00001048919,0.004338634,0.001478857,0.1488409,0.6981307],"study_design_scores_gemma":[0.001663388,0.00006076717,0.00006477674,0.006648146,0.000954256,0.00001021279,0.0001216287,0.000004064043,0.002727093,0.0001975945,0.9867651,0.0007829701],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007959685,0.9876254,0.0004694056,0.000297486,0.000463637,0.003407901,0.002100543,0.0002111714,0.004628439],"genre_scores_gemma":[0.0008476955,0.9898198,0.001482989,0.0002950832,0.0003604533,0.001236941,0.001156413,0.0003270968,0.004473574],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8379242,"threshold_uncertainty_score":0.9994426,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2068541511","doi":"10.1016/j.drup.2004.07.002","title":"Leishmaniasis: drugs in the clinic, resistance and new developments","year":2004,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":403,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Centers for Disease Control and Prevention","keywords":"Miltefosine; Pentamidine; Leishmaniasis; Leishmania; Medicine; Antifungal drugs; Amphotericin B; Drug resistance; Antifungal; Pharmacology; Fluconazole; Intensive care medicine; Immunology; Visceral leishmaniasis; Biology; Dermatology; Internal medicine; Microbiology; Pneumonia; Parasite hosting; Computer science","authors":[{"name":"Marc Ouellette","is_ca":true},{"name":"Jolyne Drummelsmith","is_ca":true},{"name":"Barbara Papadopoulou","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06026731808428146,"gpt":0.3660137248391854,"spread":0.3057464067549039,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001950837,0.0009378267,0.003031614,0.000509827,0.0003230118,0.000236661,0.001015974,0.0003378083,0.00009861014],"category_scores_gemma":[0.0009193463,0.0006186926,0.000428301,0.001357844,0.0004318048,0.0002306891,0.0003331375,0.001469924,0.0003512252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007002895,"about_ca_system_score_gemma":0.002057282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006782104,"about_ca_topic_score_gemma":0.001964471,"domain_scores_codex":[0.9942049,0.0005071255,0.001617725,0.001321495,0.001295494,0.001053268],"domain_scores_gemma":[0.996525,0.001110717,0.0005819972,0.001300806,0.0001690364,0.0003123838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005011953,0.0005178897,0.0006767788,0.10354,0.001338356,0.001053048,0.007169589,6.211141e-8,3.272118e-7,0.002662846,0.4472138,0.435326],"study_design_scores_gemma":[0.001182136,0.00001851933,0.001099971,0.04948278,0.0004611702,0.00002808626,0.0007964158,3.027099e-8,0.000001879641,0.0007445295,0.9456463,0.000538216],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000677912,0.9787748,0.000002129958,0.004159588,0.0001428874,0.002378875,0.00004138586,0.0000912042,0.01434137],"genre_scores_gemma":[0.00005792103,0.939746,0.002311092,0.00040273,0.0002403271,0.000410589,0.0001492619,0.0001288394,0.05655322],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4984324,"threshold_uncertainty_score":0.9996265,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2114168745","doi":"10.1016/j.drup.2015.08.001","title":"International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus","year":2015,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":330,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Sanofi Pasteur; Astellas Foundation for Research on Metabolic Disorders; Astellas Pharma; Bundesministerium für Bildung und Forschung; Cidara Therapeutics; National Institute of Allergy and Infectious Diseases; Medical Research Council; Celgene; Pfizer; Dainippon Sumitomo Pharma; Janssen Pharmaceuticals; Gilead Sciences; Radboud Universiteit; Sanofi; European Commission; Viropharma; Bristol-Myers Squibb","keywords":"Azole; Voriconazole; Micafungin; Aspergillosis; Aspergillus fumigatus; Itraconazole; Echinocandin; Medicine; Intensive care medicine; Drug resistance; Aspergillus; Amphotericin B; Esophageal candidiasis; Microbiology; Biology; Antifungal; Immunology; Fluconazole; Dermatology","authors":[{"name":"Paul E. Verweij","is_ca":false},{"name":"Michelle Ananda‐Rajah","is_ca":false},{"name":"David R. Andes","is_ca":false},{"name":"Maiken Cavling Arendrup","is_ca":false},{"name":"Roger J. M. Brüggemann","is_ca":false},{"name":"Anuradha Chowdhary","is_ca":false},{"name":"Oliver A. Cornely","is_ca":false},{"name":"David W. Denning","is_ca":false},{"name":"Andreas H. Groll","is_ca":false},{"name":"Koichi Izumikawa","is_ca":false},{"name":"Bart Jan Kullberg","is_ca":false},{"name":"Katrien Lagrou","is_ca":false},{"name":"Johan Maertens","is_ca":false},{"name":"Jacques F. Meis","is_ca":false},{"name":"Pippa Newton","is_ca":false},{"name":"Iain Page","is_ca":false},{"name":"Seyedmojtaba Seyedmousavi","is_ca":false},{"name":"Donald C. Sheppard","is_ca":true},{"name":"Claudio Viscoli","is_ca":false},{"name":"Adilia Warris","is_ca":false},{"name":"J. Peter Donnelly","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02548187277548414,"gpt":0.295827424816365,"spread":0.2703455520408809,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005041565,0.0002083842,0.0002777335,0.00007283226,0.00009923992,0.00003187878,0.0001898645,0.00006835489,0.000160784],"category_scores_gemma":[0.00008523469,0.0001438945,0.0001269695,0.0002348691,0.0001733259,0.0001164179,0.00006279167,0.0001813376,0.00004187704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672614,"about_ca_system_score_gemma":0.00005713381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007871979,"about_ca_topic_score_gemma":0.00008901655,"domain_scores_codex":[0.998134,0.00007683423,0.0004069259,0.0003747248,0.0007508572,0.0002567151],"domain_scores_gemma":[0.9988011,0.00007678089,0.0001668057,0.000571263,0.0002477523,0.000136293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008996502,0.001508984,0.03147315,0.0005241836,0.001104717,0.00007942488,0.002006072,0.00002657847,0.02239121,0.04699656,0.8799626,0.004930051],"study_design_scores_gemma":[0.002314814,0.0001502816,0.06138514,0.0008479279,0.0000459668,0.000001546322,0.001937914,0.00009504702,0.03417406,0.000839199,0.8978859,0.0003221527],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8872639,0.004823238,0.0002723379,0.01291122,0.001242956,0.0009131014,0.0001036515,0.0001490778,0.09232054],"genre_scores_gemma":[0.9905267,0.00246819,0.0002509396,0.0005241955,0.0001181373,0.00004698907,0.0001467427,0.00002418924,0.005893857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032629,"threshold_uncertainty_score":0.5867848,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2087950464","doi":"10.1016/s1368-7646(02)00021-3","title":"Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms","year":2002,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":324,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"","keywords":"Ganciclovir; Foscarnet; Virology; Famciclovir; Herpes simplex virus; Cidofovir; Biology; Thymidine kinase; Valaciclovir; Herpesviridae; Antiviral drug; Drug resistance; Human cytomegalovirus; Nucleoside analogue; DNA polymerase; Cytomegalovirus; Virus; Polymerase; Nucleoside; Viral disease; DNA; Microbiology; Genetics","authors":[{"name":"Christian Gilbert","is_ca":true},{"name":"Julie Bestman‐Smith","is_ca":true},{"name":"Guy Boivin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03304748137064542,"gpt":0.3666449093710895,"spread":0.3335974280004441,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005686864,0.0007086801,0.003033951,0.0003637879,0.0001238942,0.00005715514,0.0002331458,0.0003913755,0.0001043572],"category_scores_gemma":[0.000301682,0.0005623357,0.0007094367,0.0007462201,0.0002146485,0.000111403,0.0001284235,0.0004913657,0.0001806496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001682804,"about_ca_system_score_gemma":0.0002427023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002055584,"about_ca_topic_score_gemma":0.0001275293,"domain_scores_codex":[0.9962787,0.0003212666,0.001448159,0.0009413242,0.0004671481,0.0005434242],"domain_scores_gemma":[0.9974432,0.0003479995,0.0006051353,0.001034927,0.0001656279,0.0004030817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002185347,0.001210344,0.00007666645,0.02625335,0.001774322,0.0005229791,0.0001824802,7.502094e-8,0.000006866282,0.004475813,0.01794421,0.9473343],"study_design_scores_gemma":[0.0007001061,0.00007553306,0.00002273706,0.02219055,0.001591547,0.000008964042,0.00002712312,3.673686e-7,0.0001918948,0.0003902131,0.9743655,0.0004354216],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006301739,0.989424,0.00008802327,0.0002051074,0.0002251621,0.00138802,0.0002936181,0.0001004314,0.007645418],"genre_scores_gemma":[0.001960911,0.9870592,0.005334311,0.0002797933,0.00009410037,0.0001187132,0.000087471,0.0001335664,0.0049319],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9564213,"threshold_uncertainty_score":0.9996828,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4200113990","doi":"10.1016/j.drup.2021.100794","title":"An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment","year":2021,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":292,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"CancerCare Manitoba; Children's Hospital Research Institute of Manitoba; University of Manitoba; Research Institute in Oncology and Hematology","funders":"Silesian University of Technology","keywords":"Medicine; Hydroxychloroquine; Pandemic; Lopinavir; Coronavirus disease 2019 (COVID-19); Ribavirin; Intensive care medicine; Ritonavir; Interim analysis; Clinical endpoint; Randomized controlled trial; Interim; Disease; Internal medicine; Viral load; Virology; Virus; Infectious disease (medical specialty)","authors":[{"name":"Sylwester Drożdżal","is_ca":false},{"name":"Jakub Rosik","is_ca":false},{"name":"Kacper Lechowicz","is_ca":false},{"name":"Filip Machaj","is_ca":false},{"name":"Bartosz Szostak","is_ca":false},{"name":"Jarosław Przybyciński","is_ca":false},{"name":"Shahrokh Lorzadeh","is_ca":false},{"name":"Katarzyna Kotfis","is_ca":false},{"name":"Saeid Ghavami","is_ca":true},{"name":"Marek Łoś","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.113283966716191,"gpt":0.4875776992917716,"spread":0.3742937325755806,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008883828,0.001143461,0.004027178,0.0003737506,0.0004619413,0.0001792887,0.0006012281,0.0003328297,0.00009750039],"category_scores_gemma":[0.002416648,0.0007173044,0.001279411,0.0006887084,0.0004635231,0.0001189094,0.0001201943,0.0006345221,0.0001066383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001697894,"about_ca_system_score_gemma":0.003916149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006787918,"about_ca_topic_score_gemma":0.0002933538,"domain_scores_codex":[0.9942971,0.0005523588,0.001106826,0.001932024,0.001038641,0.001072984],"domain_scores_gemma":[0.9917403,0.004754325,0.0005318614,0.002017793,0.0003811745,0.000574471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003423296,0.002478233,0.00001281262,0.0631431,0.005517912,0.00115249,0.0003991605,0.0000168861,0.00002055902,0.002342797,0.02316328,0.8983294],"study_design_scores_gemma":[0.002598856,0.0008441064,0.000002613739,0.008337136,0.003311886,0.00000554406,0.00008659492,0.00002113741,0.0001034771,0.0003095644,0.9836964,0.0006826796],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004221933,0.9855965,0.0006398534,0.008150595,0.0001767451,0.004227161,0.0007550411,0.0002296725,0.0001821669],"genre_scores_gemma":[0.000283118,0.9839632,0.001149051,0.00593786,0.0005590876,0.001929115,0.002054855,0.0002292635,0.003894477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9605331,"threshold_uncertainty_score":0.9995278,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2040642086","doi":"10.1016/j.drup.2012.06.001","title":"Insights into the global molecular epidemiology of carbapenem non-susceptible clones of Acinetobacter baumannii","year":2012,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":262,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"","keywords":"Acinetobacter baumannii; Multilocus sequence typing; Biology; Microbiology; Antibiotics; Molecular epidemiology; Antibiotic resistance; Carbapenem; Outbreak; Population; Multiple drug resistance; Typing; Genetics; Virology; Gene; Medicine; Bacteria; Genotype; Pseudomonas aeruginosa; Environmental health","authors":[{"name":"Nabil Karah","is_ca":false},{"name":"Arnfinn Sundsfjord","is_ca":false},{"name":"K. J. Towner","is_ca":true},{"name":"Ørjan Samuelsen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01943733421591278,"gpt":0.3102078049370245,"spread":0.2907704707211118,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005830742,0.0007393055,0.002336445,0.00008436517,0.00009691252,0.0000120102,0.001364083,0.0006536494,0.00003301319],"category_scores_gemma":[0.0002402438,0.0004989798,0.0008029109,0.0003907421,0.0008744527,0.00001284329,0.000452684,0.0002708186,0.00002510761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008286064,"about_ca_system_score_gemma":0.0002907199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006971764,"about_ca_topic_score_gemma":0.0004545482,"domain_scores_codex":[0.9960527,0.000695317,0.001588973,0.000813062,0.0002518505,0.0005980912],"domain_scores_gemma":[0.996001,0.0001943839,0.001618313,0.001797954,0.0002539693,0.0001343497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002749257,0.002613661,0.1401984,0.2473121,0.01752784,0.0001523172,0.002599523,0.00007047201,0.04972718,0.07052216,0.06229586,0.4042312],"study_design_scores_gemma":[0.0002080463,0.00005969948,0.001225202,0.00276671,0.0007499917,0.000006070465,0.00007269545,5.86228e-7,0.002889323,0.0005684959,0.9908928,0.0005603585],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03081047,0.9665425,0.0001955216,0.00006255846,0.0004117082,0.0006778553,0.0001058944,0.00001199996,0.001181468],"genre_scores_gemma":[0.0713379,0.9249665,0.00168437,0.00007804477,0.0002910356,0.00004824196,0.0008054341,0.00008171314,0.0007067539],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.928597,"threshold_uncertainty_score":0.9997462,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2029697713","doi":"10.1016/j.drup.2008.08.005","title":"SPARC in cancer biology: Its role in cancer progression and potential for therapy","year":2008,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"Matricellular protein; Cancer; Colorectal cancer; Cancer research; Biology; Tumor progression; Ovarian cancer; Cancer cell; Phenotype; Medicine; Extracellular matrix; Genetics; Gene","authors":[{"name":"Isabella T. Tai","is_ca":true},{"name":"Michelle Tang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04108337212371253,"gpt":0.3901327339218124,"spread":0.3490493617980998,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000139345,0.0003770924,0.001547705,0.0002085482,0.00008807272,0.00001435115,0.000108691,0.0002344287,0.00003082936],"category_scores_gemma":[0.00002995099,0.0002607337,0.0001647648,0.0002887716,0.0001415621,0.00006326444,0.00006874092,0.0003129838,0.000003941095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631013,"about_ca_system_score_gemma":0.0002245716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001992889,"about_ca_topic_score_gemma":0.00188754,"domain_scores_codex":[0.9983233,0.00007548794,0.0005114413,0.0005569203,0.0001416916,0.0003911462],"domain_scores_gemma":[0.9993824,0.0000692711,0.0002293581,0.0001911791,0.00006420493,0.00006357204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004541842,0.0001640736,0.001501166,0.007608241,0.0001435535,0.00005475879,0.0001955028,2.42502e-7,0.00003099035,0.00005055812,0.00469209,0.9851046],"study_design_scores_gemma":[0.001412535,0.00004234172,0.0004728189,0.01812331,0.0000854567,0.000007975914,0.00004359417,0.000003689304,0.0001040028,0.0001545093,0.9792641,0.0002855978],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002162096,0.994204,0.000001011841,0.0005441284,0.0001542132,0.00257004,0.0001583115,0.00002705467,0.0001791066],"genre_scores_gemma":[0.001171815,0.9938505,0.0001905092,0.0001188326,0.0002277505,0.002895087,0.0001226441,0.00004991783,0.00137294],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9848191,"threshold_uncertainty_score":0.9999845,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4387731505","doi":"10.1016/j.drup.2023.101012","title":"Antibiotic failure: Beyond antimicrobial resistance","year":2023,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Perelman School of Medicine, University of Pennsylvania; Defense Threat Reduction Agency; Killam Trusts; Brain and Behavior Research Foundation; National Institute of General Medical Sciences; United Therapeutics Corporation; International Association for Dental Research; University of British Columbia; University of Pennsylvania; National Institutes of Health; ACE Foundation; Procter and Gamble","keywords":"Antibiotic resistance; Antibiotics; Intensive care medicine; Medicine; Sepsis; Antimicrobial; Microbiome; Biology; Microbiology; Immunology; Bioinformatics","authors":[{"name":"César de la Fuente‐Núñez","is_ca":false},{"name":"Angela Cesaro","is_ca":false},{"name":"Robert E. W. Hancock","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01472030605848085,"gpt":0.2833561460175726,"spread":0.2686358399590917,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0006349034,0.001322565,0.00240623,0.0003074488,0.0003590519,0.0003155433,0.001768848,0.0009507719,0.00005164929],"category_scores_gemma":[0.000344607,0.001242034,0.001009454,0.0009635788,0.000559817,0.0000209646,0.0005461416,0.0006088631,0.0009118116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001447889,"about_ca_system_score_gemma":0.0006163245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005691327,"about_ca_topic_score_gemma":0.001290683,"domain_scores_codex":[0.9942601,0.0003953724,0.001509339,0.002096719,0.0004989973,0.00123942],"domain_scores_gemma":[0.9960614,0.0001413793,0.001063049,0.00227685,0.0002081005,0.0002492447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001730263,0.0001503317,0.00006901849,0.046186,0.001030673,0.0002226513,0.00004143605,9.024533e-7,0.001082355,0.001084996,0.9375142,0.01244445],"study_design_scores_gemma":[0.0002886075,0.00001389371,0.0000205624,0.01279331,0.0004630923,0.00001649407,0.00003137959,1.381337e-7,0.0009143683,0.0001118733,0.9840173,0.001328991],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003516009,0.9933212,0.00004416396,0.0002397328,0.001042873,0.001193157,0.0009671331,0.0002182485,0.002621862],"genre_scores_gemma":[0.0001191512,0.9167069,0.002400936,0.000124641,0.0009940229,0.00003792693,0.00366407,0.0004378938,0.07551446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.07661433,"threshold_uncertainty_score":0.9999526,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2092643107","doi":"10.1016/j.drup.2011.01.001","title":"Creeping baselines and adaptive resistance to antibiotics","year":2011,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Antibiotic resistance; Resistance (ecology); Adaptive response; Adaptation (eye); Biology; Antibiotics; Mechanism (biology); Drug resistance; Intensive care medicine; Evolutionary biology; Biotechnology; Genetics; Medicine; Ecology; Neuroscience","authors":[{"name":"Lucía Fernández","is_ca":true},{"name":"Elena B. M. Breidenstein","is_ca":true},{"name":"Robert E. W. Hancock","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02539359851969317,"gpt":0.2899207888008317,"spread":0.2645271902811385,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000493395,0.0009364848,0.001638212,0.0002028707,0.0002327426,0.000136019,0.0008528588,0.0005180823,0.00003345032],"category_scores_gemma":[0.0003489062,0.0008630737,0.0003531063,0.0004008079,0.0003321195,0.00001555592,0.0004641582,0.0003228435,0.0000864118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006625064,"about_ca_system_score_gemma":0.0002622365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008388645,"about_ca_topic_score_gemma":0.0007412886,"domain_scores_codex":[0.9961821,0.0002790679,0.0009808446,0.001562588,0.0002456027,0.0007497338],"domain_scores_gemma":[0.997399,0.0001044806,0.0005879801,0.001363241,0.0002350457,0.0003102848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002422795,0.000591365,0.0008344284,0.07140138,0.002989891,0.0003326948,0.0006876436,0.000002576163,0.001486663,0.01708144,0.4901262,0.4120429],"study_design_scores_gemma":[0.0001502807,0.00003349514,0.00005350245,0.009340495,0.0003015679,0.00000895339,0.00006080601,3.814088e-7,0.0006221975,0.0001106346,0.9883242,0.0009934948],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003520645,0.9942415,0.0006742161,0.00007175542,0.0003507289,0.0009562486,0.0003927073,0.0000575485,0.002903231],"genre_scores_gemma":[0.0004073755,0.9634632,0.01633538,0.0001749051,0.000507994,0.000015145,0.0004539964,0.0001956038,0.01844634],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.498198,"threshold_uncertainty_score":0.999382,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2794341756","doi":"10.1016/j.drup.2018.01.004","title":"Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018","year":2018,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Hepatitis C virus research","field":"Medicine","cited_by":196,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"NS5A; Hepatitis C virus; NS5B; NS3; Medicine; Virology; Drug resistance; Hepacivirus; Virus; Drug development; Drug; Pharmacology; Biology; Genetics","authors":[{"name":"M.C. Sorbo","is_ca":false},{"name":"Valeria Cento","is_ca":false},{"name":"Velia Chiara Di Maio","is_ca":false},{"name":"A Howe","is_ca":true},{"name":"Féderico García","is_ca":false},{"name":"Carlo Federico Perno","is_ca":false},{"name":"Francesca Ceccherini‐Silberstein","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05785593860325694,"gpt":0.3852783326130977,"spread":0.3274223940098408,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.00328452,0.001345684,0.004744844,0.0005566364,0.000810038,0.0002930858,0.001016099,0.0009382582,0.0005071074],"category_scores_gemma":[0.004796112,0.001082489,0.001085556,0.001625715,0.0022921,0.0004094344,0.0004672068,0.002353713,0.001628912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009745129,"about_ca_system_score_gemma":0.001681647,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003287019,"about_ca_topic_score_gemma":0.03582162,"domain_scores_codex":[0.9905546,0.001667407,0.002862698,0.002202811,0.001162669,0.001549771],"domain_scores_gemma":[0.9922881,0.002242331,0.001303442,0.002372418,0.0008852573,0.0009084478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002651135,0.0004989182,0.00135589,0.01347653,0.001467512,0.0004408293,0.0002189577,3.312388e-8,0.000002400372,0.001195468,0.8541077,0.1269707],"study_design_scores_gemma":[0.0009117073,0.00003682937,0.000276464,0.02410156,0.0008205778,0.00001321962,0.00001759749,0.000008116387,0.00002529049,0.0006059623,0.9722102,0.0009724233],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000680635,0.9849201,0.00004788065,0.001246881,0.0009008892,0.002299168,0.002799099,0.0004136358,0.006691693],"genre_scores_gemma":[0.0001732099,0.9481309,0.001352418,0.000404718,0.0008733062,0.0004052495,0.00229531,0.0002866231,0.04607827],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1259983,"threshold_uncertainty_score":0.9999479,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2920869071","doi":"10.1016/j.drup.2018.03.003","title":"Glioblastoma cancer stem cell biology: Potential theranostic targets","year":2019,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; Southlake Regional Health Center; CancerCare Manitoba","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; Royan Institute","keywords":"Glioblastoma; Stem cell; Cancer stem cell; Biology; Cancer research; Stem cell biology; Brain cancer; Cancer; Computational biology; Medicine; Cell biology; Genetics; Gene","authors":[{"name":"Farzaneh Sharifzad","is_ca":false},{"name":"Saeid Ghavami","is_ca":true},{"name":"Javad Verdi","is_ca":false},{"name":"Soura Mardpour","is_ca":false},{"name":"Mahsa Mollapour Sisakht","is_ca":false},{"name":"Zahra Azizi","is_ca":true},{"name":"Adeleh Taghikhani","is_ca":false},{"name":"Marek Łoś","is_ca":false},{"name":"Esmail Fakharian","is_ca":false},{"name":"Marzieh Ebrahimi","is_ca":false},{"name":"Amir Ali Hamidieh","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02210126948574178,"gpt":0.3150508559541841,"spread":0.2929495864684424,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002307087,0.0007945446,0.002974621,0.0002793841,0.000112805,0.00005627048,0.0004125235,0.0003793602,0.001105125],"category_scores_gemma":[0.00001095212,0.0005847544,0.0009840504,0.0004658985,0.0001855112,0.00006969893,0.0001168857,0.0006246417,0.0006871647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003366769,"about_ca_system_score_gemma":0.0008805168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006064652,"about_ca_topic_score_gemma":0.0002074348,"domain_scores_codex":[0.9969035,0.0001834878,0.0008243953,0.00101915,0.0003443899,0.0007250719],"domain_scores_gemma":[0.9978893,0.0001408394,0.0006107494,0.0009689046,0.0001520462,0.0002381745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003003106,0.0001608642,0.000008507243,0.06119087,0.0007730171,0.0001343501,0.00009465907,0.000002473872,0.000105386,0.00008931261,0.05310979,0.8840305],"study_design_scores_gemma":[0.0007280765,0.00004962127,0.000001798505,0.01058604,0.003498488,0.00001191751,0.00003370977,0.000001739272,0.0003969063,0.00002163187,0.9841091,0.0005609829],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005264286,0.9926587,0.00003073018,0.0002355613,0.001731274,0.00151871,0.0009911878,0.0001155219,0.002665644],"genre_scores_gemma":[0.0002406679,0.9519296,0.0001900952,0.0002242431,0.0006718951,0.0002442988,0.0004082733,0.000174046,0.04591691],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9309993,"threshold_uncertainty_score":0.999808,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3042832159","doi":"10.1016/j.drup.2020.100719","title":"FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy","year":2020,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":189,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Lopinavir; Hydroxychloroquine; Favipiravir; Ritonavir; Azithromycin; Clinical trial; Chloroquine; Pharmacology; Intensive care medicine; Virology; Immunology; Disease; Antibiotics; Coronavirus disease 2019 (COVID-19); Malaria; Virus; Internal medicine; Viral load; Biology","authors":[{"name":"Sylwester Drożdżal","is_ca":false},{"name":"Jakub Rosik","is_ca":false},{"name":"Kacper Lechowicz","is_ca":false},{"name":"Filip Machaj","is_ca":false},{"name":"Katarzyna Kotfis","is_ca":false},{"name":"Saeid Ghavami","is_ca":true},{"name":"Marek Łoś","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.12587865412803,"gpt":0.4819622007752686,"spread":0.3560835466472386,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001033164,0.001151475,0.004098468,0.0003096565,0.0003938201,0.0001435766,0.0009227297,0.0003142131,0.00009916577],"category_scores_gemma":[0.003865519,0.0007679267,0.001392739,0.0009809671,0.0006501484,0.0001275338,0.0002092142,0.001171561,0.0001084188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007154908,"about_ca_system_score_gemma":0.003710932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004526776,"about_ca_topic_score_gemma":0.00004867995,"domain_scores_codex":[0.9942173,0.0004044591,0.001305278,0.001795608,0.001166948,0.001110437],"domain_scores_gemma":[0.9912487,0.005906236,0.0007337342,0.00110838,0.000374077,0.0006288585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006275537,0.0005703489,0.000006441063,0.1242232,0.004966293,0.0003665461,0.000537411,0.000002181644,0.0001776342,0.0002213237,0.08466923,0.7779838],"study_design_scores_gemma":[0.004690424,0.0002373092,8.804772e-7,0.004705299,0.001822889,0.000004180079,0.00005338473,0.00005372222,0.0001959558,0.0002983143,0.9871658,0.0007718063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008622872,0.9692115,0.001734234,0.02110909,0.0001949345,0.006656244,0.0004858732,0.0003598797,0.0002396875],"genre_scores_gemma":[0.00008568936,0.9752555,0.001581246,0.01542502,0.0008752171,0.002187741,0.0004609842,0.0003020416,0.003826585],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9024966,"threshold_uncertainty_score":0.9994771,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2767031674","doi":"10.1016/j.drup.2017.10.003","title":"Not only P-glycoprotein: Amplification of the ABCB1- containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins","year":2017,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministry of Health, British Columbia; Sapienza Università di Roma; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Multiple drug resistance; Biology; Efflux; P-glycoprotein; Cancer cell; Cancer research; Drug resistance; ATP-binding cassette transporter; Epigenetics; Locus (genetics); Vinca; Gene; Cancer; Genetics; Pharmacology; Transporter","authors":[{"name":"Ilaria Genovese","is_ca":false},{"name":"Andrea Ilari","is_ca":false},{"name":"Yehuda G. Assaraf","is_ca":false},{"name":"Francesco Fazi","is_ca":false},{"name":"Gianni Colotti","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03416051113123444,"gpt":0.3147363883626371,"spread":0.2805758772314026,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001348285,0.001317568,0.004892108,0.0003933191,0.0004918713,0.00006123066,0.001699738,0.001022617,0.00008527827],"category_scores_gemma":[0.0002344798,0.0009583204,0.001218969,0.0008429695,0.0009610433,0.0004042492,0.0001422035,0.001267289,0.000004534545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006975317,"about_ca_system_score_gemma":0.001900025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003209004,"about_ca_topic_score_gemma":0.001954725,"domain_scores_codex":[0.9913219,0.0006509455,0.003574154,0.001625501,0.001934917,0.0008926194],"domain_scores_gemma":[0.986235,0.0002483266,0.008426139,0.003477938,0.001288003,0.0003245438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0254202,0.007027572,0.0003510589,0.4242955,0.007555497,0.0004076548,0.006866892,0.00005636146,0.3832351,0.01259862,0.03065748,0.1015281],"study_design_scores_gemma":[0.003906821,0.0001555326,0.0003361277,0.1835759,0.002494704,0.000007223701,0.0004689618,0.00001073978,0.2360561,0.000268355,0.5714388,0.001280633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01464682,0.9684001,0.0001184336,0.0008151308,0.0007390606,0.01028835,0.003303383,0.0001700171,0.001518705],"genre_scores_gemma":[0.1437783,0.8245227,0.001437721,0.00003916992,0.0001113182,0.0008403044,0.001661875,0.0003207228,0.02728782],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5407814,"threshold_uncertainty_score":0.9999576,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1964137986","doi":"10.1016/s1368-7646(02)00003-1","title":"Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway","year":2002,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"National Cancer Institute","keywords":"XIAP; Ovarian cancer; PI3K/AKT/mTOR pathway; Protein kinase B; Cancer research; Cisplatin; Inhibitor of apoptosis; Programmed cell death; Apoptosis; Biology; Kinase; Cancer; Signal transduction; Cancer cell; Cell biology; Caspase; Chemotherapy; Genetics","authors":[{"name":"Jin Q. Cheng","is_ca":false},{"name":"Xiuxian Jiang","is_ca":true},{"name":"Michael Fraser","is_ca":true},{"name":"Ming Li","is_ca":true},{"name":"Han C. Dan","is_ca":false},{"name":"Mei Sun","is_ca":false},{"name":"Benjamin K. Tsang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009680834590482428,"gpt":0.2352078145243284,"spread":0.2255269799338459,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003422109,0.0003800518,0.001130573,0.0001536253,0.00003551475,0.000009657787,0.000506226,0.0003405531,0.00002714474],"category_scores_gemma":[0.00004030895,0.0002922296,0.0003696431,0.0006049505,0.0001457485,0.000007882102,0.0001686107,0.0001958397,5.409917e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001076709,"about_ca_system_score_gemma":0.0002902971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002933046,"about_ca_topic_score_gemma":0.002314588,"domain_scores_codex":[0.9974899,0.000169095,0.001193495,0.0005301844,0.0003185727,0.0002988101],"domain_scores_gemma":[0.9979498,0.00002168575,0.001112162,0.0007422194,0.0001317355,0.00004235174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002972557,0.000807711,0.0005090471,0.0311214,0.0002317387,0.000003223075,0.0004020466,0.00005627538,0.8372142,0.002091301,0.0005480893,0.1267177],"study_design_scores_gemma":[0.0005715075,0.0000330929,0.0001840171,0.01498954,0.00007712253,2.800578e-7,0.00007997495,0.000006865915,0.8564706,0.0002828916,0.1269817,0.0003224328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04903374,0.9490101,0.000004795957,0.00003724858,0.00009081006,0.001371721,0.0002311444,0.000003751662,0.0002166479],"genre_scores_gemma":[0.1206753,0.876807,0.0005251077,0.000009488369,0.00006435286,0.0003296602,0.0002076967,0.0000537317,0.001327696],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1264336,"threshold_uncertainty_score":0.999953,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2273626774","doi":"10.1016/j.drup.2016.02.001","title":"Could drugs inhibiting the mevalonate pathway also target cancer stem cells?","year":2016,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba","funders":"","keywords":"Mevalonate pathway; Cancer; Cancer stem cell; Cancer research; Carcinogenesis; Cancer cell; Metastasis; Hippo signaling pathway; Biology; Signal transduction; Epithelial–mesenchymal transition; Stem cell; Cell biology; Bioinformatics; Reductase; Genetics; Biochemistry; Enzyme","authors":[{"name":"Wirginia Likus","is_ca":false},{"name":"Krzysztof Siemianowicz","is_ca":false},{"name":"Konrad Bieńk","is_ca":false},{"name":"Malgorzata Maria Pakula","is_ca":false},{"name":"Himani Pathak","is_ca":false},{"name":"Chhanda Dutta","is_ca":false},{"name":"Qiong Wang","is_ca":false},{"name":"Shahla Shojaei","is_ca":false},{"name":"Yehuda G. Assaraf","is_ca":false},{"name":"Saeid Ghavami","is_ca":true},{"name":"Artur Cieślar‐Pobuda","is_ca":false},{"name":"Marek Łoś","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01300497741820996,"gpt":0.2755649961688785,"spread":0.2625600187506685,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007341068,0.0007987148,0.001351352,0.00008331416,0.0003301604,0.0001263965,0.0009538818,0.0004441585,0.0001268643],"category_scores_gemma":[0.00003317637,0.0004877157,0.0007346542,0.0002321981,0.0003369106,0.00001249104,0.0003199941,0.0004200156,0.0001023366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100702,"about_ca_system_score_gemma":0.0007831385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003734529,"about_ca_topic_score_gemma":0.0002589645,"domain_scores_codex":[0.99647,0.0003666422,0.0008498245,0.001096739,0.0004285513,0.0007882254],"domain_scores_gemma":[0.9976615,0.00009815443,0.0007818285,0.001083078,0.0002049234,0.0001705161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005492965,0.00003718957,0.000001846298,0.004862116,0.0004198558,0.000001113924,0.000162199,0.000001792163,0.002273779,0.0005304301,0.5135236,0.4781312],"study_design_scores_gemma":[0.0002952083,0.000006994757,3.489596e-7,0.004493046,0.0002338871,0.000003309826,0.00008901489,4.051619e-7,0.007858614,0.00007112975,0.9862488,0.0006992746],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003619992,0.9868905,0.00003230359,0.0003913301,0.008332649,0.0007978465,0.001576302,0.00004705715,0.001895827],"genre_scores_gemma":[0.00004103318,0.9355831,0.00009122487,0.0003689177,0.01386876,0.000494605,0.0003283628,0.0001623149,0.04906166],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4774319,"threshold_uncertainty_score":0.9997575,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1965156600","doi":"10.1016/j.drup.2011.04.002","title":"The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms","year":2011,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Government of Ontario","keywords":"Efflux; Kinase; Biology; Cancer research; Pharmacology; Signal transduction; Cancer; Drug resistance; Cell biology; Genetics","authors":[{"name":"Methvin Isaac","is_ca":true},{"name":"Allan Siu","is_ca":true},{"name":"Jan Jongstra","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03263143506265965,"gpt":0.2976015274292069,"spread":0.2649700923665473,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001081541,0.001446254,0.003257677,0.0001941027,0.0009595597,0.0002252828,0.001347783,0.0004912399,0.0002342911],"category_scores_gemma":[0.000180023,0.0009654578,0.001561382,0.0009306544,0.0004176005,0.0002537718,0.0002383395,0.001146671,0.0003432698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006180725,"about_ca_system_score_gemma":0.0008606339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001303225,"about_ca_topic_score_gemma":0.00242822,"domain_scores_codex":[0.9939932,0.0004070251,0.001708511,0.001662042,0.000892024,0.00133723],"domain_scores_gemma":[0.994274,0.0008357445,0.001256767,0.002931127,0.0003556075,0.0003467329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002355411,0.0006036052,0.000001442651,0.02689348,0.002785033,0.000562868,0.001971121,3.044738e-7,0.0004099339,0.2163695,0.2893827,0.4586647],"study_design_scores_gemma":[0.001138826,0.00003546255,0.000002136574,0.01514497,0.001250943,0.00001937278,0.0002778054,0.00000137805,0.001294644,0.02913539,0.9507085,0.000990559],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002428911,0.9892417,0.000312675,0.0008951024,0.001575059,0.002690139,0.0003048506,0.0003738657,0.004582366],"genre_scores_gemma":[0.00006125392,0.8896371,0.005460809,0.000544092,0.0005674492,0.0007701174,0.0003997663,0.0003661224,0.1021934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6613258,"threshold_uncertainty_score":0.9998287,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2156149052","doi":"10.1016/j.drup.2006.08.001","title":"Methods and biomarkers for the diagnosis and prognosis of cancer and other diseases: Towards personalized medicine","year":2006,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"CancerCare Manitoba; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Space Agency; CancerCare Manitoba Foundation; Muscular Dystrophy Association; Manitoba Health Research Council; Manitoba Medical Service Foundation; Health Sciences Centre Foundation; Parent Project Muscular Dystrophy","keywords":"Personalized medicine; Cancer; Computational biology; Bioinformatics; Biology; Medicine; Genetics","authors":[{"name":"Judy E. Anderson","is_ca":true},{"name":"Lise Lotte Hansen","is_ca":false},{"name":"Frank C. Mooren","is_ca":false},{"name":"Markus Post","is_ca":false},{"name":"Hubert Hug","is_ca":false},{"name":"Anne Zuse","is_ca":true},{"name":"Marek Łoś","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.080257720066636,"gpt":0.4580474344439079,"spread":0.3777897143772719,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009849855,0.0004433684,0.001982901,0.0002382708,0.0001894002,0.00005293217,0.0001669059,0.0001678785,0.000151525],"category_scores_gemma":[0.0003760264,0.0002410746,0.0002435318,0.0003886024,0.001320789,0.00004947611,0.0001070033,0.0002158667,3.915313e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007381428,"about_ca_system_score_gemma":0.0002458186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001280316,"about_ca_topic_score_gemma":0.0006832837,"domain_scores_codex":[0.9978404,0.000204961,0.0006081058,0.0006242807,0.000359166,0.0003630522],"domain_scores_gemma":[0.9969229,0.00204626,0.0003237711,0.0003431789,0.000155291,0.0002086211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002859467,0.0000574118,0.002675828,0.0378544,0.001085463,0.000004283479,0.0002009478,7.469978e-9,0.000002888785,0.0002752923,0.02398484,0.9335727],"study_design_scores_gemma":[0.001198978,0.00004774412,0.0008053872,0.01189878,0.00410633,0.000004638264,0.0001526444,0.00001343874,0.00001932043,0.0001207558,0.9813948,0.0002372145],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001309275,0.9928027,0.00003367704,0.002811128,0.0000544393,0.002743158,0.001189134,0.0000230475,0.0002117391],"genre_scores_gemma":[0.0000329763,0.992547,0.002391721,0.0001782585,0.0002089035,0.002401824,0.00007288472,0.00008379419,0.002082686],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9574099,"threshold_uncertainty_score":0.9830735,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4211153257","doi":"10.1016/j.drup.2003.10.002","title":"DNA methylation and cancer therapy","year":2003,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; CpG site; Methylation; Biology; DNA methyltransferase; Epigenomics; RNA-Directed DNA Methylation; Methyltransferase; DNA; Illumina Methylation Assay; Epigenetics of physical exercise; Epigenetics; Cancer epigenetics; Cancer research; Genetics; Molecular biology; Gene; Gene expression","authors":[{"name":"Moshe Szyf","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02666833700517556,"gpt":0.3297473750495071,"spread":0.3030790380443315,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002687047,0.0003283014,0.0005455446,0.00006663772,0.00009616883,0.00005477769,0.000147377,0.0002664079,0.0000327934],"category_scores_gemma":[0.00003207344,0.000274974,0.0001606156,0.0001356989,0.00006478553,0.000003663713,0.00003947702,0.000117572,0.000006266093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002305361,"about_ca_system_score_gemma":0.0001258145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005853065,"about_ca_topic_score_gemma":0.00006977186,"domain_scores_codex":[0.9985947,0.0001924882,0.0003444314,0.0005250974,0.0001281825,0.000215124],"domain_scores_gemma":[0.9991833,0.00003250864,0.000264479,0.0003776584,0.00007293281,0.00006914716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001295322,0.00002022592,0.00002110459,0.001269133,0.0001383266,9.69174e-7,0.00002005935,0.000001018183,0.001158804,0.0001337222,0.002447784,0.9947759],"study_design_scores_gemma":[0.0001398986,0.00001158717,0.000008968434,0.0005099867,0.00008775597,4.694348e-7,0.000004300351,3.33866e-7,0.005102828,0.0002064266,0.9936104,0.000317063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005031818,0.9977698,0.00007256731,0.00003542143,0.000178644,0.0003776672,0.00006897416,0.00001062159,0.0009831074],"genre_scores_gemma":[0.0000610999,0.9926135,0.0004252791,0.00004664714,0.0001910926,0.0001252016,0.0005296068,0.00005979955,0.005947753],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9944589,"threshold_uncertainty_score":0.9999703,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1973344697","doi":"10.1016/j.drup.2015.01.001","title":"RhoGTPases – A novel link between cytoskeleton organization and cisplatin resistance","year":2015,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"RhoC; RHOA; RHOB; Biology; Actin cytoskeleton; Cell biology; PAK1; CDC42; Cisplatin; GTPase; Cytoskeleton; Cancer research; Kinase; Signal transduction; Cell; Genetics","authors":[{"name":"Daphna Mokady","is_ca":true},{"name":"David Meiri","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02294902211328728,"gpt":0.2889868471376309,"spread":0.2660378250243436,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004529996,0.0005492315,0.001023327,0.0001390013,0.0001906467,0.0001221367,0.0003354235,0.0004557203,0.0000205492],"category_scores_gemma":[0.0003757877,0.0005110942,0.0001565311,0.0004713986,0.0001423882,0.00001341048,0.0002025285,0.0002308263,0.00002196274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006868324,"about_ca_system_score_gemma":0.0003842757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002848526,"about_ca_topic_score_gemma":0.00006412052,"domain_scores_codex":[0.9976617,0.0001531398,0.0006722619,0.0008527203,0.0003033597,0.0003567958],"domain_scores_gemma":[0.9982269,0.00006100007,0.0005483201,0.0006452623,0.0003165978,0.0002019603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001737252,0.0001359155,0.0001854067,0.03728547,0.0009563445,0.000051404,0.0002082319,0.000009026533,0.003349533,0.004061335,0.07600697,0.8775766],"study_design_scores_gemma":[0.0003339495,0.00001261478,0.000008213355,0.00307419,0.0002741623,0.00000578482,0.00001001183,7.954164e-7,0.001445967,0.0001404592,0.9941148,0.0005791116],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001319762,0.9967301,0.001277356,0.0001802858,0.00007760445,0.0006510608,0.0004141706,0.0000568852,0.0004805066],"genre_scores_gemma":[0.0004161981,0.9829603,0.003259404,0.00004857948,0.001266837,0.00006184097,0.00566277,0.000136554,0.006187463],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9181077,"threshold_uncertainty_score":0.999734,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1976097884","doi":"10.1054/drup.2001.0190","title":"Lamivudine resistance in hepatitis B: mechanisms and clinical implications","year":2001,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Lamivudine; Virology; Hepatitis B virus; Hepatitis B; Medicine; Nucleoside analogue; Seroconversion; Orthohepadnavirus; Immunology; Viral replication; Biology; Virus; Hepadnaviridae; Nucleoside; Genetics","authors":[{"name":"Karl P. Fischer","is_ca":true},{"name":"Klaus S. Gutfreund","is_ca":false},{"name":"D. Lorne Tyrrell","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04996537674272774,"gpt":0.37843679687203,"spread":0.3284714201293022,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008169821,0.0006651334,0.003276606,0.0003594708,0.0001888501,0.0000568353,0.0003146551,0.0003949284,0.00008425487],"category_scores_gemma":[0.0007991656,0.0005834479,0.0004209238,0.001039445,0.0003308443,0.0001182995,0.0002073842,0.0008312835,0.0001384439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003608574,"about_ca_system_score_gemma":0.0003330501,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002412334,"about_ca_topic_score_gemma":0.0653663,"domain_scores_codex":[0.9957228,0.0003185823,0.001823933,0.001148522,0.0003510836,0.0006350594],"domain_scores_gemma":[0.9970987,0.0008249995,0.000577493,0.001063759,0.0001844769,0.0002505718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001784188,0.0008226408,0.04386612,0.04289608,0.001271769,0.001052819,0.0002589998,3.94577e-8,0.000001216512,0.09466539,0.1508548,0.6641317],"study_design_scores_gemma":[0.0005119718,0.00002229089,0.008119199,0.01878111,0.0007523245,0.00002160198,0.000008063831,6.964323e-7,6.342442e-7,0.004597895,0.9666985,0.000485767],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005519357,0.9886236,0.0001069079,0.00253693,0.0001942626,0.001520263,0.0003315485,0.0001438175,0.006487436],"genre_scores_gemma":[0.0001070862,0.9745488,0.007567749,0.0002993523,0.0002176788,0.0004701873,0.0003850155,0.0001257748,0.01627833],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8158436,"threshold_uncertainty_score":0.9996617,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2073200741","doi":"10.1016/j.drup.2012.03.003","title":"Immunotherapy: A useful strategy to help combat multidrug resistance","year":2012,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Center for Research Resources; National Cancer Institute; National Institute on Aging; Fondation des Etoiles; Owens Foundation","keywords":"Immunotherapy; Cytotoxic T cell; Multiple drug resistance; Immune system; Cancer immunotherapy; Cancer; Immunology; Medicine; Biology; Drug resistance; Internal medicine; Microbiology","authors":[{"name":"Tyler J. Curiel","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03083223295627444,"gpt":0.2973822250195601,"spread":0.2665499920632857,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.00121709,0.001714487,0.003832425,0.0006886931,0.0007967907,0.0002042895,0.002136206,0.001102244,0.002055019],"category_scores_gemma":[0.0001274348,0.001446451,0.001210546,0.001033751,0.0005346576,0.0004226975,0.0002833204,0.001528326,0.007378822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004146896,"about_ca_system_score_gemma":0.0005246327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005923504,"about_ca_topic_score_gemma":0.0003394127,"domain_scores_codex":[0.9926044,0.001927375,0.001938358,0.001365158,0.0002092082,0.001955511],"domain_scores_gemma":[0.9950525,0.001135646,0.001042797,0.002431051,0.0002107342,0.000127258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002142621,0.0007213444,0.00001351466,0.008554398,0.003159418,0.00004390313,0.001510259,8.319116e-7,0.00244303,0.001919952,0.1090016,0.8704892],"study_design_scores_gemma":[0.001056992,0.0000506639,0.00004557195,0.008061578,0.0005092108,0.00003920418,0.0001952226,2.215461e-8,0.001298523,0.00006651186,0.9870666,0.001609919],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002131742,0.9926878,0.00003751521,0.0001993712,0.001888185,0.002135453,0.0006629806,0.0003984094,0.001777089],"genre_scores_gemma":[0.0003246892,0.8091929,0.0002569638,0.0002565921,0.0001458744,0.000583411,0.00104548,0.0002983036,0.1878958],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.878065,"threshold_uncertainty_score":0.9995601,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2071822666","doi":"10.1054/drup.2000.0126","title":"Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase","year":2000,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Medical Research Council; Health Canada","keywords":"Reverse transcriptase; Context (archaeology); Nucleoside; Drug resistance; Biology; Nucleoside Reverse Transcriptase Inhibitor; Enzyme; Drug; Human immunodeficiency virus (HIV); Virology; Amino acid; Genetics; Pharmacology; RNA; Biochemistry; Gene","authors":[{"name":"Matthias Götte","is_ca":false},{"name":"Mark A. Wainberg","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006801987319243661,"gpt":0.2251592288602605,"spread":0.2183572415410168,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002920231,0.0003156516,0.0005939751,0.0002551328,0.00006812155,0.00001783256,0.0001770785,0.0001069732,0.0005655698],"category_scores_gemma":[0.00007018176,0.0002972959,0.0001448689,0.0006865715,0.000087591,0.0001374541,0.00002520198,0.0001934388,0.0001384436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433964,"about_ca_system_score_gemma":0.0001098309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000247203,"about_ca_topic_score_gemma":0.0005581941,"domain_scores_codex":[0.9977983,0.00005858469,0.000686229,0.0005529395,0.0004419879,0.0004619548],"domain_scores_gemma":[0.9990538,0.00007225132,0.00009015392,0.0004655504,0.00007034039,0.0002479267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007893604,0.001678354,0.02547235,0.001051908,0.0002908642,0.0009206276,0.009563596,0.00001396052,0.3194974,0.005262636,0.627015,0.001339682],"study_design_scores_gemma":[0.004598878,0.00002607691,0.003930583,0.002504603,0.0001356784,0.000003235554,0.001204256,0.0000151962,0.7554456,0.001695204,0.2298629,0.0005778003],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810832,0.001138389,0.00004629677,0.01207261,0.00007320155,0.0007251552,0.00008095516,0.00008917,0.004691077],"genre_scores_gemma":[0.9227651,0.0002145745,0.02653412,0.0006694918,0.00004245634,0.00007282256,0.0001432674,0.00005131244,0.04950684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4359482,"threshold_uncertainty_score":0.9999479,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1986171300","doi":"10.1016/j.drup.2004.06.004","title":"Prediction of drug sensitivity and drug resistance in cancer by transcriptional and proteomic profiling","year":2004,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre; Institute for Research in Immunology and Cancer; McGill University","funders":"National Cancer Institute; Cancer Research Society; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; Breast Cancer Alliance; Cancer Research Institute","keywords":"Drug resistance; Proteomics; Computational biology; Drug; Biology; Bioinformatics; Drug response; Cancer; Tumor microenvironment; Drug development; Medicine; Pharmacology; Gene; Genetics","authors":[{"name":"Moulay A. Alaoui‐Jamali","is_ca":true},{"name":"Ilaria Dupré","is_ca":true},{"name":"He Qiang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01158990424308681,"gpt":0.2557509097724516,"spread":0.2441610055293648,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004213526,0.0004016288,0.000815687,0.00009558376,0.0000838278,0.00004174995,0.000125146,0.0002036238,0.000003139677],"category_scores_gemma":[0.00006267773,0.0004021228,0.0001298245,0.0001521451,0.0002316918,0.00001210413,0.00007344307,0.0002522446,4.798667e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001361108,"about_ca_system_score_gemma":0.0004602008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001512387,"about_ca_topic_score_gemma":0.004889717,"domain_scores_codex":[0.9980278,0.0001406097,0.0006010943,0.0007583149,0.0001749706,0.000297233],"domain_scores_gemma":[0.9990988,0.00006913736,0.0003471721,0.0003073987,0.00008718324,0.00009031004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004198785,0.002398092,0.01152851,0.4320975,0.003331307,0.0002156822,0.004433511,0.000267939,0.2007323,0.01264511,0.1195211,0.2086302],"study_design_scores_gemma":[0.0009369933,0.0000151615,0.0002412321,0.01070093,0.0002961758,0.000004923445,0.00004669363,0.000004912854,0.01033025,0.0003652406,0.9764598,0.000597711],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0311109,0.964375,0.000034704,0.0001724311,0.0001292588,0.0009473085,0.003148166,0.00001018213,0.00007210956],"genre_scores_gemma":[0.007666021,0.988841,0.0009503252,0.0000303223,0.0001280169,0.0002464644,0.001099551,0.00005593432,0.000982387],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8569387,"threshold_uncertainty_score":0.9998431,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2071538535","doi":"10.1016/j.drup.2009.02.001","title":"Mutational ‘hot-spots’ in mammalian, bacterial and protozoal dihydrofolate reductases associated with antifolate resistance: Sequence and structural comparison","year":2009,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Antifolate; Biology; Dihydrofolate reductase; Plasmodium falciparum; Genetics; Antimetabolite; Malaria; Gene; Immunology","authors":[{"name":"Jordan P. Volpato","is_ca":true},{"name":"Joelle N. Pelletier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02741926110272969,"gpt":0.3193452072151339,"spread":0.2919259461124042,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003723382,0.0008631636,0.00243715,0.0003637758,0.000234821,0.0001817487,0.0001697556,0.0002873334,0.00005706422],"category_scores_gemma":[0.0001480383,0.0006396216,0.0001164861,0.0007158576,0.0003284576,0.0002666076,0.00005870358,0.0005470756,0.000008702164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004227345,"about_ca_system_score_gemma":0.0006638627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001193071,"about_ca_topic_score_gemma":0.00077661,"domain_scores_codex":[0.9964055,0.0002696295,0.001093697,0.001047805,0.0005518763,0.0006315287],"domain_scores_gemma":[0.9983082,0.0002315009,0.0007050202,0.0003519655,0.0001676567,0.0002356372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02541844,0.003174328,0.08365779,0.1290128,0.01135429,0.02272874,0.01480517,0.000009774079,0.0003200686,0.004531953,0.05471365,0.650273],"study_design_scores_gemma":[0.007688511,0.0001528826,0.02897224,0.08200377,0.00283279,0.0003023031,0.0002244386,0.0000362361,0.0001955623,0.0006616826,0.8745025,0.002427043],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1008383,0.8942894,8.689531e-7,0.0006328863,0.00009893669,0.003204757,0.0004914432,0.0001050617,0.0003383514],"genre_scores_gemma":[0.02654507,0.9389901,0.003228456,0.00004745043,0.0001725761,0.0004860791,0.007697449,0.000145675,0.02268721],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8197889,"threshold_uncertainty_score":0.9996055,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1986396848","doi":"10.1016/j.drup.2008.04.001","title":"Progress and challenges in the identification of biomarkers for EGFR and VEGFR targeting anticancer agents","year":2008,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre","funders":"Fondation de France; American Association for Cancer Research","keywords":"Medicine; Biomarker; Biomarker discovery; Trastuzumab; Imatinib; Drug; Clinical trial; Breast cancer; Druggability; Personalized medicine; Sunitinib; Oncology; Cancer; Pharmacology; Bioinformatics; Cancer research; Internal medicine; Biology; Proteomics","authors":[{"name":"Christophe Le Tourneau","is_ca":true},{"name":"Laura Vidal","is_ca":true},{"name":"Lillian L. Siu","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1392766723441191,"gpt":0.4201719401740726,"spread":0.2808952678299535,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001417958,0.0002812232,0.001034031,0.0002438361,0.00009964693,0.00004018622,0.00027048,0.0001505932,0.000006599477],"category_scores_gemma":[0.0003789114,0.0001934426,0.0001262515,0.0003547504,0.000496749,0.00007105821,0.00006441647,0.0002534679,0.000001858674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001130142,"about_ca_system_score_gemma":0.0002182159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000010476,"about_ca_topic_score_gemma":0.0000557923,"domain_scores_codex":[0.9975621,0.0002400079,0.000811452,0.0005712656,0.0004602918,0.0003549294],"domain_scores_gemma":[0.9983803,0.000529208,0.0004248497,0.0004517404,0.0001415042,0.00007239567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000111361,0.0001123102,0.0004552274,0.1043303,0.0002133804,0.00003086095,0.001114276,2.869265e-8,0.000006997485,0.0002651465,0.009955782,0.8834043],"study_design_scores_gemma":[0.0004174492,0.00002738478,0.0006188655,0.01291823,0.0001808089,0.00001800541,0.000434662,0.00001101993,0.00004260354,0.00006999879,0.9850876,0.0001733453],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004401326,0.9947869,0.000001897446,0.001966704,0.00009253107,0.00241609,0.00009307302,0.00001536133,0.0001873581],"genre_scores_gemma":[0.001060572,0.997253,0.0004257958,0.00002089951,0.0001022122,0.0007384467,0.0001286308,0.00005194875,0.0002185001],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9751319,"threshold_uncertainty_score":0.7888359,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1993572662","doi":"10.1054/drup.2002.0235","title":"HIV drug resistance and implications for the introduction of antiretroviral therapy in resource-poor countries","year":2001,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Intensive care medicine; Drug resistance; Antiretroviral therapy; Developing country; Human immunodeficiency virus (HIV); Drug; Transmission (telecommunications); Resource (disambiguation); Immunology; Viral load; Pharmacology; Biology; Computer science","authors":[{"name":"Marco Petrella","is_ca":true},{"name":"Bluma Brenner","is_ca":true},{"name":"Hugues Loemba","is_ca":true},{"name":"Mark A. Wainberg","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00856328859968757,"gpt":0.2516728424776016,"spread":0.243109553877914,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003919327,0.0001815547,0.0003151254,0.0001289882,0.0002102264,0.00003210729,0.0001235581,0.00004146872,0.00002965208],"category_scores_gemma":[0.00008382401,0.0001259826,0.00006162973,0.0003585472,0.0002354469,0.0001128656,0.00002050871,0.00009921685,0.000004770628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008828307,"about_ca_system_score_gemma":0.00007172097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000702148,"about_ca_topic_score_gemma":0.0005352753,"domain_scores_codex":[0.9987935,0.00004213633,0.0003779807,0.0003475588,0.0001737755,0.0002650598],"domain_scores_gemma":[0.9989943,0.0002852981,0.0001490251,0.0003876899,0.0001341605,0.00004956171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003704391,0.0002998833,0.2537687,0.0002146232,0.0002147274,0.00000796237,0.003067195,0.000003873911,0.001365452,0.01467877,0.7185008,0.004173573],"study_design_scores_gemma":[0.002059793,0.0000166171,0.06148317,0.00009631277,0.0000556786,0.000004122769,0.0007819856,0.00001381994,0.004956183,0.001018732,0.9293721,0.000141511],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6181298,0.01681751,0.0001769702,0.3621609,0.0000716589,0.001415891,0.00008168203,0.00006798698,0.001077593],"genre_scores_gemma":[0.8478168,0.008057942,0.00291986,0.0005455331,0.000268463,0.0003167636,0.0002574721,0.00004019863,0.139777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3616153,"threshold_uncertainty_score":0.5137421,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1971110677","doi":"10.1016/j.drup.2004.02.004","title":"New cancer therapeutics: target-specific in, cytotoxics out?","year":2004,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Cancer; Clinical trial; Biomarker; Medicine; Drug development; Proteomics; Targeted therapy; Biomarker discovery; Computational biology; Drug; Cancer research; Bioinformatics; Pharmacology; Biology; Internal medicine","authors":[{"name":"Henk J. Broxterman","is_ca":false},{"name":"N H Georgopapadakou","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008700666978959477,"gpt":0.2475809144283475,"spread":0.238880247449388,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009000349,0.0002051387,0.0001743245,0.0000498019,0.00006133868,0.00004031004,0.000293787,0.0001301937,0.00005570279],"category_scores_gemma":[0.000006584309,0.0002009738,0.00008084909,0.0001163768,0.00005438034,0.000007437447,0.00006206375,0.0001291305,0.00003691981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006914083,"about_ca_system_score_gemma":0.0001792127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004981668,"about_ca_topic_score_gemma":0.004596759,"domain_scores_codex":[0.9988467,0.00002380987,0.0002420895,0.0004171884,0.0001203557,0.0003498694],"domain_scores_gemma":[0.9993787,0.000006032696,0.00007497851,0.0004073379,0.00005180921,0.00008111564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002188551,0.0001176208,0.003867042,0.00003499928,0.00007813434,0.00001385949,0.0005593497,0.0005486188,0.9652116,0.002091147,0.02496254,0.002296205],"study_design_scores_gemma":[0.0007807819,0.00001398414,0.0007388833,0.00004579612,0.000007582387,9.88407e-7,0.0001034547,0.000002912932,0.4615269,0.001643097,0.5348682,0.0002673456],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252902,0.05394362,0.01175055,0.003901512,0.0007451115,0.0005710445,0.0001181884,0.00006320898,0.003616597],"genre_scores_gemma":[0.9521315,0.01898093,0.01332249,0.001928266,0.0006141311,0.00006217672,0.000273578,0.0000829698,0.01260398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5099057,"threshold_uncertainty_score":0.8195472,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1987122879","doi":"10.1016/s1368-7646(03)00024-4","title":"The interface between ErbB and non-ErbB receptors in tumor invasion: clinical implications and opportunities for target discovery","year":2003,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"National Cancer Institute; Breast Cancer Society of Canada; Cancer Research Society","keywords":"ErbB; Biology; Receptor tyrosine kinase; Receptor; Drug discovery; Signal transduction; Cancer research; Context (archaeology); Cell signaling; Bioinformatics; Cell biology; Genetics","authors":[{"name":"Moulay A. Alaoui‐Jamali","is_ca":true},{"name":"He Qiang","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1794879031040422,"gpt":0.4597632419439453,"spread":0.2802753388399031,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00239364,0.0004449474,0.00177973,0.0001900924,0.0002772326,0.000214334,0.0004095877,0.0002292345,0.00002023493],"category_scores_gemma":[0.0007608687,0.0002991697,0.0002426631,0.0003029466,0.000879575,0.0001761379,0.0001815542,0.0008782707,0.000007391382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002620954,"about_ca_system_score_gemma":0.001178485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001041062,"about_ca_topic_score_gemma":0.000153621,"domain_scores_codex":[0.9966128,0.0004264247,0.001300643,0.0007928692,0.0003049629,0.0005622268],"domain_scores_gemma":[0.9952672,0.00306939,0.0003919193,0.0008299757,0.0001465943,0.0002949393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001829534,0.0001321337,0.004239474,0.02137075,0.0003314235,0.00002779662,0.0002408799,6.048754e-8,6.201404e-7,0.0019429,0.2467198,0.7248112],"study_design_scores_gemma":[0.0004565823,0.00006297731,0.0003035417,0.01335523,0.0002517445,0.00001135275,0.0004373995,8.454636e-7,0.000007858036,0.0009899351,0.9838315,0.0002910189],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003948279,0.9888625,0.00007838844,0.00647726,0.000225968,0.002566868,0.0004706029,0.00002642727,0.0008971205],"genre_scores_gemma":[0.000350993,0.9856692,0.0009060206,0.0001626984,0.0002864587,0.0004739467,0.0003071827,0.00009494929,0.01174858],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7371117,"threshold_uncertainty_score":0.9999461,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1969152525","doi":"10.1016/j.drup.2004.06.001","title":"The emergence of HIV resistance and new antiretrovirals: are we winning?","year":2004,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Human immunodeficiency virus (HIV); Resistance (ecology); Perspective (graphical); Antiretroviral therapy; Virology; Medicine; Biology; Viral load; Computer science; Artificial intelligence; Ecology","authors":[{"name":"Mark A. Wainberg","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03205993354073074,"gpt":0.3110628451451023,"spread":0.2790029116043716,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003740809,0.0005277605,0.001435579,0.0001347681,0.0005046682,0.00005315406,0.0007532777,0.0002888017,0.0001916941],"category_scores_gemma":[0.0001990076,0.0003304782,0.0003212576,0.0004145951,0.0007756462,0.0000942981,0.0001838877,0.0005559861,0.0004431362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000858339,"about_ca_system_score_gemma":0.0005682825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003639192,"about_ca_topic_score_gemma":0.0006431057,"domain_scores_codex":[0.9973389,0.0003883247,0.0007836568,0.0006626926,0.0001287099,0.0006977123],"domain_scores_gemma":[0.9976843,0.0005657272,0.0007132059,0.0008588919,0.00009672051,0.00008116222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002964817,0.0001588444,0.0002402234,0.02011144,0.001695454,0.0001010768,0.0004315887,2.810089e-7,0.00003984672,0.005838985,0.7107593,0.2603265],"study_design_scores_gemma":[0.0004636238,0.0000205346,0.00003012875,0.01495722,0.0002493893,0.000007655383,0.0001672451,9.798385e-9,0.0001415056,0.0005358204,0.983138,0.0002889051],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001826979,0.9961923,0.00001011288,0.001179773,0.0002305393,0.0006235847,0.0006382771,0.00004898345,0.001058134],"genre_scores_gemma":[0.000160301,0.9046106,0.0001471883,0.000008880394,0.00003677561,0.0000653826,0.0003464751,0.00004413871,0.09458022],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2723787,"threshold_uncertainty_score":0.9999147,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4407599227","doi":"10.1016/j.drup.2025.101213","title":"Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis","year":2025,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"H2020 Marie Skłodowska-Curie Actions; FP7 People: Marie-Curie Actions; National Institutes of Health; Universidad de Zaragoza; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; European Commission; Horizon 2020 Framework Programme","keywords":"Antibiotics; Medicine; Lactam; Tuberculosis; Microbiology; Chemistry; Biology; Pathology","authors":[{"name":"Santiago Ramón‐García","is_ca":false},{"name":"Rubén González del Río","is_ca":false},{"name":"María Pilar Arenaz-Callao","is_ca":false},{"name":"Helena I. Boshoff","is_ca":false},{"name":"Joaquín Rullás","is_ca":false},{"name":"Sara Anca","is_ca":false},{"name":"Mónica Cacho Izquierdo","is_ca":false},{"name":"Esther Porras de Francisco","is_ca":false},{"name":"Ángel Santos-Villarejo","is_ca":false},{"name":"Alfonso Mendoza-Losana","is_ca":false},{"name":"Santiago Ferrer","is_ca":false},{"name":"Charles J. Thompson","is_ca":true},{"name":"David Barros-Aguirre","is_ca":false},{"name":"Robert H. Bates","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0657759882485501,"gpt":0.4339001372049818,"spread":0.3681241489564316,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005605721,0.0002784904,0.0004357399,0.0001456505,0.0003613621,0.00003125038,0.0004320788,0.0001397058,0.0002426939],"category_scores_gemma":[0.00006237077,0.0001983098,0.0002188849,0.0004204543,0.0002584402,0.0000799617,0.00003572955,0.0001618428,0.00001235243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006614984,"about_ca_system_score_gemma":0.0001070123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000346595,"about_ca_topic_score_gemma":0.0002123117,"domain_scores_codex":[0.9982834,0.0002730099,0.0004711094,0.0004064807,0.0001293402,0.0004366828],"domain_scores_gemma":[0.9981829,0.0008649175,0.0001655242,0.0004824807,0.0001802292,0.0001239321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008455484,0.009004921,0.02931999,0.0007991453,0.004395681,0.00003549804,0.004399977,0.001835287,0.3008798,0.03455114,0.1331189,0.4732042],"study_design_scores_gemma":[0.002236254,0.00006076068,0.003247507,0.00001357556,0.0005809608,4.865198e-7,0.0001459674,0.001544646,0.3374683,0.0008718527,0.6536742,0.0001554709],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952772,0.03250471,0.0003081024,0.005750358,0.002140427,0.001811961,0.0005006104,0.0001050469,0.004106759],"genre_scores_gemma":[0.9795031,0.009910298,0.001039054,0.001410389,0.0001784271,0.0001229189,0.00008643094,0.00002803269,0.007721345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5205553,"threshold_uncertainty_score":0.8086837,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2800029404","doi":"10.1016/j.drup.2018.04.001","title":"Corrigendum to “Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018” [Drug Resist. Updates 37 (March) (2018) 17–39]","year":2018,"lang":"en","type":"erratum","venue":"Drug Resistance Updates","topic":"Hepatitis C virus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Drug; Virology; Drug resistance; Medicine; Relevance (law); Hepatitis C virus; Virus; Biology; Pharmacology; Genetics; Political science","authors":[{"name":"M.C. Sorbo","is_ca":false},{"name":"Valeria Cento","is_ca":false},{"name":"Velia Chiara Di Maio","is_ca":false},{"name":"A Howe","is_ca":true},{"name":"Féderico García","is_ca":false},{"name":"Carlo Federico Perno","is_ca":false},{"name":"Francesca Ceccherini‐Silberstein","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03217018304041553,"gpt":0.3204840388718854,"spread":0.2883138558314698,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"category_scores_codex":[0.005367243,0.002504271,0.004482939,0.00122712,0.002060788,0.0008163412,0.002707999,0.001815597,0.002190707],"category_scores_gemma":[0.00951257,0.002329597,0.001039736,0.002724676,0.003116342,0.0008643367,0.00150438,0.005811763,0.003014106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002140601,"about_ca_system_score_gemma":0.003344106,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002599646,"about_ca_topic_score_gemma":0.2533631,"domain_scores_codex":[0.9825117,0.002112121,0.004076357,0.004535797,0.003120997,0.003643023],"domain_scores_gemma":[0.9863964,0.001596018,0.001852463,0.004998547,0.00257751,0.002579022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001884977,0.0006342974,0.004653988,0.0008985268,0.00103361,0.0006080035,0.0006958464,5.575346e-7,0.0001786192,0.0005369418,0.9880206,0.0008540261],"study_design_scores_gemma":[0.002300143,0.0001351231,0.01217405,0.005303761,0.0005203464,0.00001337257,0.000186102,0.00007564545,0.0008172584,0.001909979,0.9742983,0.002265895],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.1183345,0.2384021,0.0006112518,0.1479362,0.1291994,0.02321674,0.08192635,0.006302427,0.2540711],"genre_scores_gemma":[0.009090344,0.1277713,0.0032319,0.003829553,0.004227102,0.0006463262,0.01384217,0.0007582922,0.836603],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.5825319,"threshold_uncertainty_score":0.9995966,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W7117586634","doi":"10.1016/j.drup.2025.101349","title":"AMPKα2 attenuates doxorubicin induced ferroptosis by promoting NCOA4 degradation in triple negative breast cancer","year":2025,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Medical and Health Research Project of Zhejiang Province; Natural Science Foundation of Ningbo; Higher Education Discipline Innovation Project; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Triple-negative breast cancer; Doxorubicin; Degradation (telecommunications); Breast cancer; Cancer; Apoptosis","authors":[{"name":"Xinjun Liu","is_ca":false},{"name":"Zizhen Si","is_ca":false},{"name":"Linbo Li","is_ca":false},{"name":"Miao Zhou","is_ca":false},{"name":"Ki-Young Lee","is_ca":true},{"name":"Xidi Wang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01015032993666657,"gpt":0.2806916703124635,"spread":0.2705413403757969,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004812713,0.0003475629,0.0006198796,0.0002989646,0.0001826785,0.00008755196,0.0002202997,0.0001418691,0.0002011761],"category_scores_gemma":[0.0001775675,0.0003083191,0.0001231452,0.001421287,0.00009756235,0.0002883744,0.0000706594,0.0004051417,0.00001477542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005316912,"about_ca_system_score_gemma":0.0002637548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001754784,"about_ca_topic_score_gemma":0.004961199,"domain_scores_codex":[0.9975705,0.0001684488,0.0006565393,0.0006968921,0.0003683622,0.0005392167],"domain_scores_gemma":[0.9988484,0.0001469988,0.0002367606,0.0003820984,0.0002568869,0.000128835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002289886,0.001191214,0.5623966,0.001302307,0.000470967,0.0000225849,0.003397057,0.00001087858,0.2118804,0.0007279586,0.1560293,0.06028093],"study_design_scores_gemma":[0.005877025,0.00006739356,0.2487111,0.004215442,0.0003069725,0.000003879378,0.003298369,0.000715474,0.7267988,0.0005709192,0.008676149,0.0007585454],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672327,0.002535252,0.00002780069,0.02700824,0.0002318862,0.001006511,0.0001523339,0.0001238384,0.001681432],"genre_scores_gemma":[0.9911399,0.0007271681,0.0003407935,0.00122566,0.00007501157,0.0005716123,0.0001385915,0.00004211585,0.005739095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5149184,"threshold_uncertainty_score":0.9999369,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4410266122","doi":"10.1016/j.drup.2025.101251","title":"MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma","year":2025,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University; Princess Margaret Cancer Centre; University Health Network","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero della Salute; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"PTEN; Downregulation and upregulation; Head and neck squamous-cell carcinoma; Cancer research; microRNA; PI3K/AKT/mTOR pathway; Head and neck; Mechanism (biology); Medicine; Head and neck cancer; Basal cell; Oncology; Internal medicine; Biology; Cancer; Signal transduction; Gene; Genetics; Surgery","authors":[{"name":"Claudio Pulito","is_ca":false},{"name":"Sebastiano Vaccarella","is_ca":false},{"name":"Alina Catalina Palcau","is_ca":false},{"name":"Federica Ganci","is_ca":false},{"name":"Renata Brandi","is_ca":false},{"name":"Carlotta Frascolla","is_ca":false},{"name":"Andrea Sacconi","is_ca":false},{"name":"Valeria Canu","is_ca":false},{"name":"Anna Benedetti","is_ca":false},{"name":"Valentina De Pascale","is_ca":false},{"name":"Sara Donzelli","is_ca":false},{"name":"Anne-Sophie Fisch","is_ca":false},{"name":"Valentina Manciocco","is_ca":false},{"name":"Renato Covello","is_ca":false},{"name":"Fulvia Pimpinelli","is_ca":false},{"name":"Aldo Morrone","is_ca":false},{"name":"Raul Pellini","is_ca":false},{"name":"Paola Muti","is_ca":false},{"name":"Jalna Meens","is_ca":true},{"name":"Christina Karamboulas","is_ca":true},{"name":"Anthony C. Nichols","is_ca":true},{"name":"Sabrina Strano","is_ca":false},{"name":"Konrad Klinghammer","is_ca":false},{"name":"Ingeborg Tinhofer","is_ca":false},{"name":"Laurie Ailles","is_ca":true},{"name":"Giulia Fontemaggi","is_ca":false},{"name":"Giovanni Blandino","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005825822523603009,"gpt":0.2379051853537052,"spread":0.2320793628301022,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002310387,0.000355313,0.0004648522,0.000211127,0.00009431734,0.00002554914,0.0005469698,0.0002466265,0.00002804871],"category_scores_gemma":[0.0002009534,0.0003843919,0.0001741198,0.0005982344,0.0001606042,0.00001095344,0.0001844316,0.00007620296,0.00001464372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000960211,"about_ca_system_score_gemma":0.0003310826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001544221,"about_ca_topic_score_gemma":0.001604924,"domain_scores_codex":[0.9976202,0.00007027297,0.0007732556,0.000742341,0.0003427417,0.0004511955],"domain_scores_gemma":[0.9980111,0.00007128835,0.0004184041,0.0009302453,0.0004401149,0.0001288299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008600213,0.0001522664,0.001538652,0.0003780093,0.00003899723,0.000002360144,0.0002311968,0.0001757053,0.9839229,0.0001838392,0.01246415,0.0000519035],"study_design_scores_gemma":[0.00139481,0.00007705975,0.005246752,0.0002266876,0.00005758933,8.153025e-7,0.0001112942,0.0000254595,0.9733973,0.0003875994,0.01872211,0.0003525486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898766,0.003560619,0.003512513,0.000429539,0.0003063316,0.0005732315,0.0002668011,0.00002502695,0.00144939],"genre_scores_gemma":[0.9846965,0.00004912595,0.007970169,0.0002908298,0.0001034462,0.00007162536,0.000290001,0.00005193554,0.006476334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052563,"threshold_uncertainty_score":0.9998608,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4413147816","doi":"10.1016/j.drup.2025.101291","title":"Defining homologous recombination deficiency status in pancreatic ductal adenocarcinoma: Clinical implications for evaluating response to platinum chemotherapy","year":2025,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"MD Precision (Canada)","funders":"Science and Technology Planning Project of Guangdong Province; Guangzhou Science and Technology Program key projects; National Natural Science Foundation of China","keywords":"Pancreatic ductal adenocarcinoma; Homologous recombination; Chemotherapy; Medicine; Oncology; Adenocarcinoma; Internal medicine; Pancreatic cancer; Biology; Genetics; Cancer; Gene","authors":[{"name":"Yanxia Wang","is_ca":false},{"name":"Fan-Cheng Kong","is_ca":true},{"name":"Xiaohua Situ","is_ca":false},{"name":"Tiantian Yang","is_ca":false},{"name":"T. Sun","is_ca":true},{"name":"Zhongpeng Xie","is_ca":false},{"name":"Wang Pingling","is_ca":false},{"name":"Yu Chen","is_ca":false},{"name":"Neng Jiang","is_ca":false},{"name":"Yu Dong","is_ca":true},{"name":"Zhaofan Luo","is_ca":false},{"name":"Zunfu Ke","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03174208239471961,"gpt":0.4030723445521907,"spread":0.3713302621574711,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002300104,0.0002193712,0.0004940726,0.0004100078,0.0002149451,0.00004321228,0.0001760867,0.000120971,0.00004664572],"category_scores_gemma":[0.002382119,0.0002291052,0.0001300022,0.0009529556,0.0001119295,0.0001075496,0.00003338604,0.0002439983,0.00001883501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006036848,"about_ca_system_score_gemma":0.0006642674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002063516,"about_ca_topic_score_gemma":0.0000950328,"domain_scores_codex":[0.9973764,0.0003089412,0.0009353425,0.0006584081,0.0002078153,0.0005131304],"domain_scores_gemma":[0.9967039,0.002077501,0.0002226163,0.0005531258,0.0003158254,0.0001270703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01878553,0.0007416477,0.9011175,0.0002967053,0.0001124464,0.00001119062,0.002044292,0.00009182449,0.02239402,0.02112529,0.02006494,0.01321463],"study_design_scores_gemma":[0.007209543,0.0003060477,0.9669879,0.0005674593,0.00007566225,0.000008172819,0.0004612707,0.0002425925,0.003017391,0.01749603,0.003362408,0.0002654914],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635332,0.003790031,0.002469953,0.02689227,0.0002539104,0.001624491,0.0000885309,0.0001170628,0.001230496],"genre_scores_gemma":[0.966098,0.0002049038,0.027578,0.002131967,0.00004471448,0.0009302756,0.0001316568,0.00003845622,0.002842067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06587043,"threshold_uncertainty_score":0.9342639,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4415641574","doi":"10.1016/j.drup.2025.101319","title":"ZBP1 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Sherbrooke","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; Foundation for Innovative Research Groups of the National Natural Science Foundation of China; Foundation for Innovative Research Groups of Hubei Province of China; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Breast Cancer Research Foundation","keywords":"Synthetic lethality; Poly ADP ribose polymerase; PARP inhibitor; Ovarian cancer; DNA damage; DNA repair; Olaparib; Programmed cell death","authors":[{"name":"Shen-Nan Shi","is_ca":false},{"name":"Qiuyang Xu","is_ca":false},{"name":"Zhiqi Liao","is_ca":false},{"name":"Wenjian Gong","is_ca":false},{"name":"Yilin Cui","is_ca":false},{"name":"Jiahao Liu","is_ca":false},{"name":"Xiaofei Jiao","is_ca":false},{"name":"Yijie Wu","is_ca":false},{"name":"Mengshi Luo","is_ca":false},{"name":"Linghui Wang","is_ca":false},{"name":"Yuanjia Wen","is_ca":false},{"name":"Wen Pan","is_ca":false},{"name":"Xuejiao Zhao","is_ca":false},{"name":"Marilyne Labrie","is_ca":true},{"name":"Zhiyong Ding","is_ca":false},{"name":"Gordon B. Mills","is_ca":false},{"name":"Ding Ma","is_ca":false},{"name":"Guang‐Nian Zhao","is_ca":false},{"name":"Qinglei Gao","is_ca":false},{"name":"Yong Fang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01111696408568013,"gpt":0.3024694275648923,"spread":0.2913524634792121,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000546208,0.000236809,0.0004203502,0.0004046144,0.0001337809,0.00005569893,0.00006405922,0.0001292126,0.0002899237],"category_scores_gemma":[0.0002176251,0.0002374169,0.00005253699,0.0008207068,0.0002078517,0.000162906,0.00004028545,0.0002801191,0.00001891426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005046799,"about_ca_system_score_gemma":0.0002409691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006412218,"about_ca_topic_score_gemma":0.004547641,"domain_scores_codex":[0.9981014,0.0001676964,0.0004718966,0.0005895948,0.0002937779,0.0003756819],"domain_scores_gemma":[0.9989924,0.0002204952,0.0001082241,0.0003666686,0.0001625034,0.0001497353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01279312,0.0006657889,0.09133832,0.002208611,0.0003755084,0.0002812807,0.004618005,0.00008528855,0.7916487,0.0117717,0.08019455,0.004019149],"study_design_scores_gemma":[0.007427068,0.00009193741,0.1391697,0.004185626,0.0001155361,0.00001524176,0.001331189,0.0001008775,0.7398558,0.004780767,0.1023087,0.0006176727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545513,0.002444549,0.0002349026,0.03623175,0.0004000402,0.0008419981,0.000173276,0.0001147307,0.005007491],"genre_scores_gemma":[0.9932736,0.001195191,0.0002793607,0.002724718,0.0001016096,0.0003036771,0.0001202893,0.0000259997,0.001975604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05179294,"threshold_uncertainty_score":0.9681579,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}