{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":11,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":11,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"238d4fe56bae","filters":{"venue":"Expert Opinion on Orphan Drugs"}},"results":[{"id":"W1525227301","doi":"10.1517/21678707.2015.1046434","title":"Pathogenic mechanisms and the prospect of gene therapy for choroideremia","year":2015,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Spark Therapeutics; National Institutes of Health; Canadian Institutes of Health Research; National Institute for Health and Care Research; Alberta Innovates - Health Solutions; National Eye Institute; Wellcome Trust","keywords":"Choroideremia; Medicine; Genetic enhancement; Bioinformatics; Gene; Genetics; Biology; Ophthalmology","authors":[{"name":"Ioannis Dimopoulos","is_ca":true},{"name":"Stephanie Chan","is_ca":true},{"name":"Robert E. MacLaren","is_ca":false},{"name":"Ian M. MacDonald","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01760066621009843,"gpt":0.275906289690686,"spread":0.2583056234805876,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003001572,0.000118659,0.0001283011,0.0000212545,0.00005201804,0.00001342812,0.0001247186,0.00007117455,0.000007074372],"category_scores_gemma":[0.000050052,0.00007643385,0.0000709868,0.00003959793,0.00007852318,0.000002666354,0.0000315251,0.00002784521,0.000002143498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006591551,"about_ca_system_score_gemma":0.00006019066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007124727,"about_ca_topic_score_gemma":8.260182e-7,"domain_scores_codex":[0.9993336,0.00004371996,0.0001475256,0.0002174868,0.0001270947,0.0001306013],"domain_scores_gemma":[0.9995984,0.00001822836,0.00007092423,0.0001880402,0.00006936748,0.00005503556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006718841,0.0001973202,0.0003573189,0.00001719837,0.0001608242,4.403978e-7,0.003689794,0.00001202261,0.9035402,0.01326217,0.03456506,0.0374788],"study_design_scores_gemma":[0.008896993,0.0009817217,0.0003976369,0.00001724555,0.000002074835,0.000006138881,0.0009190952,0.00007475848,0.8313026,0.004314071,0.1528236,0.0002640282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9053733,0.06116779,0.01615648,0.005626224,0.001792802,0.003706094,0.00004382159,0.00005659991,0.006076924],"genre_scores_gemma":[0.9869492,0.006223389,0.004428936,0.001196299,0.0002487642,0.0002291924,0.0001305804,0.00003246799,0.0005611592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182585,"threshold_uncertainty_score":0.3116882,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2560073692","doi":"10.1080/21678707.2017.1264300","title":"Rare tumors in gynaecological cancers and the lack of therapeutic options and clinical trials","year":2016,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Biobank; Clinical trial; Intensive care medicine; Expert opinion; Incidence (geometry); Cancer; Pathology; Internal medicine; Bioinformatics","authors":[{"name":"Victoria Mandilaras","is_ca":true},{"name":"Katherine Karakasis","is_ca":true},{"name":"Blaise Clarke","is_ca":true},{"name":"Amit M. Oza","is_ca":true},{"name":"Stéphanie Lheureux","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1567302190808919,"gpt":0.4498017616627763,"spread":0.2930715425818844,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001356968,0.0001227747,0.0006030479,0.00005716945,0.00004074304,0.000009135162,0.00005035818,0.0000851324,0.0003358524],"category_scores_gemma":[0.0003935786,0.00005253953,0.0001173525,0.0000785516,0.0003544099,0.00003232544,0.00003017361,0.00008600663,0.000005747122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001119019,"about_ca_system_score_gemma":0.0001058048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009944119,"about_ca_topic_score_gemma":0.0000126543,"domain_scores_codex":[0.9983847,0.0005284213,0.0005355214,0.0002672368,0.0001452265,0.0001388595],"domain_scores_gemma":[0.9971124,0.002408252,0.0001490678,0.0002044637,0.00002814426,0.00009767206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005497708,0.001204508,0.1677711,0.00003635671,0.0005071778,0.000025483,0.00284239,0.000002209704,0.0001709066,0.03565934,0.00737095,0.7789119],"study_design_scores_gemma":[0.05692434,0.002528041,0.8971023,0.0008322202,0.00006256047,0.00002145782,0.001179634,0.00007728237,0.00113574,0.001735116,0.03814336,0.0002579447],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8595483,0.02825053,0.00003630173,0.1062391,0.001277648,0.002403423,0.00005131613,0.00004682715,0.002146468],"genre_scores_gemma":[0.9630728,0.03475029,0.00008027924,0.001650881,0.0001921666,0.0001433055,0.000003245444,0.000009995937,0.00009705844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7786539,"threshold_uncertainty_score":0.3677348,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4385458457","doi":"10.1080/21678707.2023.2241347","title":"Real world data for rare diseases research: The beginner’s guide to registries","year":2023,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Disease; Medical record; Rare disease; Summary of Product Characteristics; Disease registry; MEDLINE; Product (mathematics); Family medicine; Medical emergency; Data science; Drug; Pathology; Computer science; Pharmacology","authors":[{"name":"Federica Pisa","is_ca":false},{"name":"Ariel E. Arias","is_ca":true},{"name":"Emily W. Bratton","is_ca":false},{"name":"Maribel Salas","is_ca":false},{"name":"Janet Sultana","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1106638838175293,"gpt":0.423275749054378,"spread":0.3126118652368487,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004936312,0.0001713881,0.0001438116,0.0001428421,0.0004268699,0.0001047493,0.001056753,0.00004906362,0.00001989158],"category_scores_gemma":[0.0005661555,0.0001249674,0.00009483442,0.0004090833,0.000173431,0.000006408259,0.0007880355,0.0000713098,0.00008581216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002676522,"about_ca_system_score_gemma":0.0001919814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000163377,"about_ca_topic_score_gemma":0.000095176,"domain_scores_codex":[0.9982635,0.000116589,0.0002075981,0.0006664387,0.0002968966,0.0004489803],"domain_scores_gemma":[0.9977518,0.0001612002,0.00005403726,0.001672763,0.0001501283,0.0002100432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003194959,0.00005102244,0.0000923375,0.000009323975,0.00003453814,0.00000349836,0.0001524767,0.00002330658,0.003331614,0.0009952538,0.9886386,0.006348471],"study_design_scores_gemma":[0.0003396566,0.0002071805,0.001027085,0.00003182613,0.000002331722,0.000001052178,0.001305577,0.00006640352,0.004037428,0.0001376841,0.992659,0.0001847371],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6284873,0.02618627,0.001027293,0.2697758,0.01187391,0.01135344,0.02902444,0.001000264,0.02127131],"genre_scores_gemma":[0.8624,0.02350644,0.001234142,0.007612319,0.01131117,0.001744408,0.0370604,0.0003050909,0.05482607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2621635,"threshold_uncertainty_score":0.5096022,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2737330112","doi":"10.1080/21678707.2017.1359086","title":"Morbidity and mortality associated with Farber disease and prospects for therapy","year":2017,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Montreal Children's Hospital","funders":"National Institutes of Health","keywords":"Medicine; Disease; Intensive care medicine; Adult-onset Still's disease; Internal medicine","authors":[{"name":"Edward H. Schuchman","is_ca":false},{"name":"John J. Mitchell","is_ca":true},{"name":"Alex Solyom","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06523544874345108,"gpt":0.3782282851747972,"spread":0.3129928364313461,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127587,0.0001752387,0.0002541486,0.00004631277,0.0004302537,0.0001136003,0.0001059801,0.00006904555,0.00005243817],"category_scores_gemma":[0.000495511,0.0001242993,0.00004596325,0.00003938966,0.0002451841,0.0001456769,0.00005690391,0.0001150417,0.000003081477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005827547,"about_ca_system_score_gemma":0.00008670605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001806543,"about_ca_topic_score_gemma":0.00001733624,"domain_scores_codex":[0.9987864,0.00003769128,0.0001173637,0.0004062926,0.0003803979,0.000271891],"domain_scores_gemma":[0.9988958,0.00008912307,0.00009453294,0.000480457,0.0001200809,0.0003199769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005823746,0.001634668,0.9409789,0.0001465314,0.000602288,0.00007108514,0.002956741,5.206541e-7,0.001808469,0.001596287,0.01012214,0.03425866],"study_design_scores_gemma":[0.006774156,0.0007543717,0.9797542,0.0001733396,0.000007540842,0.000002782066,0.0001136131,0.0002685944,0.001320555,0.0002832006,0.01033885,0.000208805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916568,0.002899135,0.00001616471,0.003244304,0.000121606,0.001332023,0.00003377329,0.00005465527,0.0006415275],"genre_scores_gemma":[0.9966445,0.001837404,0.00005866026,0.0004379053,0.0001870286,0.000207204,0.00004636457,0.0000347778,0.0005461726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03877532,"threshold_uncertainty_score":0.5068777,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3019361312","doi":"10.1080/21678707.2020.1760837","title":"Advances in therapeutic treatment options for ANCA-associated vasculitis","year":2020,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Rituximab; Maintenance therapy; Intensive care medicine; Guideline; ANCA-Associated Vasculitis; Vasculitis; Cyclophosphamide; Expert opinion; Immunology; Internal medicine; Disease; Chemotherapy; Pathology; Lymphoma","authors":[{"name":"Shealynn Carpenter","is_ca":true},{"name":"Jan Willem Cohen Tervaert","is_ca":true},{"name":"Elaine Yacyshyn","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03436985990012032,"gpt":0.3269259203116747,"spread":0.2925560604115544,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005892464,0.0001898196,0.0003315182,0.00009910058,0.0001265747,0.00001728263,0.00006518069,0.0001256631,0.0003264519],"category_scores_gemma":[0.00004569208,0.0001498005,0.0002656014,0.0002827371,0.00003980622,0.0001072843,0.000009661386,0.0001150477,0.00008534851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002677356,"about_ca_system_score_gemma":0.00008862374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003026034,"about_ca_topic_score_gemma":0.000007018783,"domain_scores_codex":[0.9988693,0.00005591844,0.0002708677,0.0003469377,0.0001802929,0.0002766976],"domain_scores_gemma":[0.9994223,0.0000953261,0.00006175215,0.0001801148,0.0000554554,0.0001850665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001607011,0.007015645,0.003076517,0.0001721482,0.001852368,0.00008490385,0.03854395,0.0008960443,0.005193254,0.08706488,0.02346503,0.8310282],"study_design_scores_gemma":[0.02321294,0.004328285,0.006099856,0.0005116129,0.00004946961,0.00001523699,0.003035498,0.002252877,0.001943986,0.001370861,0.9566781,0.0005012722],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1267892,0.38752,0.01267502,0.3922193,0.008055695,0.01721917,0.001274976,0.00270551,0.05154105],"genre_scores_gemma":[0.9567425,0.03741571,0.0003676285,0.003339149,0.0005108056,0.0006524404,0.0005270921,0.00004899673,0.0003956718],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9332131,"threshold_uncertainty_score":0.6108686,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4391470543","doi":"10.1080/21678707.2024.2313766","title":"Orphan drugs approved in Canada: health technology assessment, price negotiation, and government formulary listing","year":2024,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":7,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"Arthur B. McDonald-Canadian Astroparticle Physics Research Institute; Fraser Institute; Wilfrid Laurier University; Canadian Institute for Health Information","funders":"","keywords":"Formulary; Medicine; Orphan drug; Listing (finance); Government (linguistics); Negotiation; List price; Pharmacology; Bioinformatics; Business; Finance; Law; Political science","authors":[{"name":"Nigel S. B. Rawson","is_ca":true},{"name":"J. F. Adams","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1247249976088999,"gpt":0.4065759861865942,"spread":0.2818509885776944,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005798995,0.0002907481,0.0008293804,0.0004241406,0.0002342779,0.0001257614,0.0002649265,0.0001470196,0.0001742395],"category_scores_gemma":[0.0006400369,0.0003582407,0.00005832735,0.0004928976,0.00004498879,0.0004451107,0.0001134055,0.0003515258,0.0001147919],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007263251,"about_ca_system_score_gemma":0.001732775,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2014091,"about_ca_topic_score_gemma":0.04131817,"domain_scores_codex":[0.9952122,0.0002158069,0.002813612,0.000898485,0.000250232,0.0006096658],"domain_scores_gemma":[0.997535,0.0007262854,0.001014616,0.0004613833,0.00003071209,0.000231938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004809505,0.0003601174,0.04472893,0.001546808,0.000214267,0.00001036275,0.02222717,0.0002554459,0.00003071529,0.7031435,0.197421,0.03001353],"study_design_scores_gemma":[0.001903711,0.0002590921,0.01831425,0.0009953112,0.000001549634,0.00001536113,0.02770219,0.06484756,0.00005003533,0.005530097,0.8794206,0.0009602239],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1965051,0.07628723,0.01538139,0.6790522,0.009880105,0.004977007,0.00102738,0.0006384026,0.01625115],"genre_scores_gemma":[0.9715785,0.002620611,0.003079239,0.02122993,0.0005704832,0.0003528716,0.00009893349,0.00008177175,0.0003876683],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7750734,"threshold_uncertainty_score":0.9998869,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2970900708","doi":"10.1080/21678707.2019.1651641","title":"Recent developments with defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome","year":2019,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"","funders":"","keywords":"Defibrotide; Medicine; Hepatic veno-occlusive disease; Transplantation; Disease; Chemotherapy; Intensive care medicine; Clinical trial; Hematopoietic stem cell transplantation; Surgery; Internal medicine","authors":[{"name":"Christine Duncan","is_ca":false},{"name":"Justine M. Kahn","is_ca":false},{"name":"Stephan A. Grupp","is_ca":false},{"name":"Paul G. Richardson","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01847546117997082,"gpt":0.2831116279990802,"spread":0.2646361668191094,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007377442,0.0002124982,0.0003173987,0.00008979747,0.00008743982,0.00001100711,0.0000718369,0.00005287874,0.0001600902],"category_scores_gemma":[0.00001426523,0.0001307749,0.00009136997,0.0001472105,0.00004612933,0.00005563943,0.000006444366,0.00004226883,0.00006680533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002778511,"about_ca_system_score_gemma":0.0001880904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002374368,"about_ca_topic_score_gemma":0.000001600392,"domain_scores_codex":[0.9987202,0.00003894933,0.0003076313,0.0003071773,0.0004070737,0.0002190018],"domain_scores_gemma":[0.999017,0.0002548757,0.0001419211,0.0003438099,0.0001133799,0.0001290044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.05977128,0.01196963,0.2462053,0.005482966,0.005620326,0.0002578863,0.1312163,0.001708669,0.02453647,0.005109093,0.004042804,0.5040793],"study_design_scores_gemma":[0.0463736,0.0199375,0.4165256,0.008248786,0.0003863946,0.000886487,0.008577267,0.002553833,0.1797823,0.0002351307,0.3148807,0.001612397],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914173,0.001698093,0.0007242517,0.001202748,0.0009413688,0.003507226,0.00004191163,0.0000570134,0.0004100832],"genre_scores_gemma":[0.9920719,0.004325342,0.002184674,0.0002012358,0.0000943702,0.0004101087,0.000261687,0.00005142606,0.0003993083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5024669,"threshold_uncertainty_score":0.5332847,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2626803060","doi":"10.1080/21678707.2017.1341307","title":"Ultra-orphan drugs: can we afford the price","year":2017,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":5,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Orphan drug; Medicine; Pharmacology; Bioinformatics","authors":[{"name":"Devidas Menon","is_ca":true},{"name":"Tania Stafinski","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2420690762339051,"gpt":0.4302075575686553,"spread":0.1881384813347502,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.008682768,0.0004242244,0.0009768442,0.0002776438,0.001737223,0.0005298313,0.001571384,0.0002418538,0.001279756],"category_scores_gemma":[0.002104623,0.0004115491,0.0002754037,0.0001356883,0.0002632274,0.0006618402,0.0001344744,0.0003551741,0.005108862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006469619,"about_ca_system_score_gemma":0.0002052899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002014376,"about_ca_topic_score_gemma":0.00007711425,"domain_scores_codex":[0.9948862,0.0003565288,0.002729137,0.0009766299,0.000258492,0.0007930477],"domain_scores_gemma":[0.9932664,0.0009808876,0.00295223,0.002357589,0.00007999304,0.0003629022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001223734,0.0004323912,0.004381773,0.0002125105,0.0002491355,0.000002807144,0.05749472,0.00006787596,0.00003306536,0.3217311,0.6041787,0.01109355],"study_design_scores_gemma":[0.001258961,0.0001403949,0.002320549,0.0002030197,0.000001590624,0.00000459329,0.004603275,0.0006119935,0.000230239,0.008344626,0.9816729,0.0006078145],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04206407,0.0131772,0.0009295311,0.7910083,0.01259549,0.002737672,0.0006292533,0.0003481347,0.1365103],"genre_scores_gemma":[0.941314,0.006641605,0.0007639813,0.04024508,0.003824584,0.0005009487,0.00008685466,0.0001448671,0.006478083],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8992499,"threshold_uncertainty_score":0.9998336,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2507172233","doi":"10.1080/21678707.2016.1232649","title":"Applying integrated care systems to rare diseases","year":2016,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Intensive care medicine","authors":[{"name":"Réjean Hébert","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1824855625707687,"gpt":0.4090593145999395,"spread":0.2265737520291708,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001891691,0.0003134935,0.0008808859,0.000484657,0.0002524198,0.0001356443,0.0004225473,0.0001526401,0.0007747642],"category_scores_gemma":[0.00149619,0.000285641,0.000153675,0.000264941,0.00005012913,0.0003946663,0.00007769429,0.00009876453,0.009431784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001282553,"about_ca_system_score_gemma":0.0001493326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005529216,"about_ca_topic_score_gemma":0.000009690006,"domain_scores_codex":[0.9958076,0.0002928352,0.00235715,0.0008525772,0.0001668169,0.0005230226],"domain_scores_gemma":[0.9970714,0.0007174576,0.0008420359,0.000776485,0.0001175379,0.0004750803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001778521,0.0002685732,0.01739563,0.0004654261,0.0001609242,0.000004002628,0.01585598,0.000224274,0.00007061812,0.1873751,0.7567148,0.02128686],"study_design_scores_gemma":[0.0009752152,0.0001313328,0.001032586,0.0006966893,8.314357e-7,0.000002029284,0.008768849,0.0002558812,0.00004647035,0.0003372548,0.9872578,0.0004950599],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1774985,0.2027493,0.07062347,0.3929341,0.06185667,0.02832591,0.01609246,0.003615812,0.04630384],"genre_scores_gemma":[0.9723378,0.0007948583,0.000733393,0.01836108,0.002135435,0.003138431,0.0002052524,0.0001291985,0.002164487],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7948394,"threshold_uncertainty_score":0.9999596,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2895884786","doi":"10.1080/21678707.2018.1536542","title":"Advances in emerging therapeutics for oculopharyngeal muscular dystrophy","year":2018,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"","funders":"","keywords":"Medicine; Oculopharyngeal muscular dystrophy; Muscular dystrophy; Internal medicine","authors":[{"name":"Pradeep Harish","is_ca":false},{"name":"George Dickson","is_ca":false},{"name":"Alberto Malerba","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03677599223228073,"gpt":0.3498005528771954,"spread":0.3130245606449146,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009280885,0.0002457307,0.0002058229,0.0001684496,0.0002164378,0.00004857576,0.0003404652,0.00004851216,0.0001080366],"category_scores_gemma":[0.0001268362,0.000223274,0.0001106723,0.0003028344,0.0001785924,0.0002047511,0.00005713992,0.00006798034,0.00008317948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004469684,"about_ca_system_score_gemma":0.0000456444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003786741,"about_ca_topic_score_gemma":0.000001915911,"domain_scores_codex":[0.9981066,0.0001744247,0.000267376,0.0006847258,0.0003494649,0.0004173895],"domain_scores_gemma":[0.9992045,0.0001774381,0.00008830959,0.0003619622,0.0000638979,0.0001038718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004960572,0.0004860524,0.0001993958,0.00002797342,0.000006996239,0.000007165777,0.003337614,0.0002216503,0.8972808,0.003664594,0.001503354,0.09276834],"study_design_scores_gemma":[0.000985792,0.0004464632,0.0002030357,0.00003608262,0.000001113499,0.00000140294,0.00017778,0.001167723,0.7692468,0.0003283331,0.2271675,0.0002379558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770301,0.005034812,0.003867063,0.002708665,0.005640419,0.001709803,0.00008210749,0.0002548654,0.00367219],"genre_scores_gemma":[0.9909181,0.002757245,0.0007682354,0.004339846,0.0008543386,0.0002088949,0.00000835107,0.00005375568,0.00009124364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2256642,"threshold_uncertainty_score":0.9104849,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2144559222","doi":"10.1517/21678707.2015.1092868","title":"Potential of antisense therapy for facioscapulohumeral muscular dystrophy","year":2015,"lang":"en","type":"article","venue":"Expert Opinion on Orphan Drugs","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Facioscapulohumeral muscular dystrophy; Gene knockdown; Muscular dystrophy; Homeobox; Medicine; Gene; Genetic enhancement; Transcription factor; Genetics; Bioinformatics; Cancer research; Biology","authors":[{"name":"Bo Bao","is_ca":true},{"name":"Toshifumi Yokota","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0193670907872162,"gpt":0.2968967167902125,"spread":0.2775296260029962,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051457,0.0001578815,0.0001704832,0.00004296247,0.00005626852,0.000006805806,0.0001511521,0.0001452286,0.00002653158],"category_scores_gemma":[0.00003151066,0.0001395597,0.0001719601,0.0000432312,0.00009494013,0.000004358692,0.00003691692,0.00004341618,0.000008699543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006017208,"about_ca_system_score_gemma":0.00005859027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001981208,"about_ca_topic_score_gemma":3.600989e-7,"domain_scores_codex":[0.9991197,0.00006773102,0.000176801,0.000309178,0.0001246817,0.0002019371],"domain_scores_gemma":[0.9994157,0.000007996669,0.00008121693,0.0003029984,0.00009706571,0.00009505478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002669126,0.0003305718,0.00008073188,0.0000100287,0.000100545,7.797335e-7,0.0003846531,0.0002114628,0.9556836,0.0003777118,0.02990022,0.01025057],"study_design_scores_gemma":[0.007293029,0.003624699,0.0008906567,0.00001965884,0.000003291751,0.000005074613,0.0007307936,0.0002290266,0.6600736,0.0005439381,0.3261307,0.000455571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991954,0.003440225,0.002473837,0.0003800145,0.0009354518,0.0003716143,0.00004446604,0.00001805012,0.0003823337],"genre_scores_gemma":[0.9969404,0.001012077,0.0005102197,0.0006079915,0.000446763,0.00004900603,0.000308848,0.00002392426,0.0001007731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2962305,"threshold_uncertainty_score":0.5691078,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}