{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":1,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":1,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"c72f79202985","filters":{"venue":"Frontiers in Chemical Biology"}},"results":[{"id":"W4401102308","doi":"10.3389/fchbi.2024.1447622","title":"Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants","year":2024,"lang":"en","type":"article","venue":"Frontiers in Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute on Aging; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Pharmaceuticals Bayer; Genentech; Innovative Medicines Initiative; Canada Foundation for Innovation; Ontario Genomics Institute; Takeda Pharmaceutical Company; European Federation of Pharmaceutical Industries and Associations; Janssen Pharmaceuticals; Merck KGaA; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; McGill University; Boehringer Ingelheim; Pfizer","keywords":"Syk; Phosphorylation; Tyrosine phosphorylation; Cell biology; Receptor; Flow cytometry; Tyrosine kinase; Tyrosine; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Biology; Chemistry; Signal transduction; Biochemistry; Molecular biology","authors":[{"name":"Jacob L. Capener","is_ca":false},{"name":"James D. Vasta","is_ca":false},{"name":"V.L. Katis","is_ca":false},{"name":"Ani Michaud","is_ca":false},{"name":"Michael Beck","is_ca":false},{"name":"Sabrina Daglish","is_ca":false},{"name":"Sarit Cohen‐Kedar","is_ca":false},{"name":"Efrat Shaham Barda","is_ca":false},{"name":"Stefanie Howell","is_ca":false},{"name":"Iris Dotan","is_ca":false},{"name":"Matthew B. Robers","is_ca":false},{"name":"Alison D. Axtman","is_ca":false},{"name":"Frances M. Bashore","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03240977483169818,"gpt":0.3117285865433949,"spread":0.2793188117116967,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000684215,0.0007380971,0.0006919074,0.0003776813,0.000263215,0.0006154305,0.0008086725,0.001213791,0.001346623],"category_scores_gemma":[0.0005395475,0.0004217341,0.0004762259,0.0002822802,0.0004869103,0.0007211067,0.000495798,0.001483952,0.0008376465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008695708,"about_ca_system_score_gemma":0.0002514662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003745386,"about_ca_topic_score_gemma":0.00104637,"domain_scores_codex":[0.9988967,0.0001664927,0.00008156792,0.0002826006,0.0004569842,0.0001155961],"domain_scores_gemma":[0.9997126,0.00008203858,0.00007208608,0.00003319894,0.0000577528,0.00004216353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000303502,0.00002182408,0.00003777216,0.00002678634,0.000004721198,0.00001474386,0.00001298447,0.0001342883,0.9988733,0.0001144249,0.00003478948,0.0006939676],"study_design_scores_gemma":[0.000005241498,0.00008848453,0.0001724258,0.000002179092,0.000004661475,0.00005085946,0.000006355751,0.001578811,0.9974606,0.00002319193,0.0006023805,0.000004783446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8647658,0.002061222,0.1251241,0.0002768195,0.0001080573,0.0004494779,0.0009514941,0.0007689327,0.005494112],"genre_scores_gemma":[0.8683944,0.002006038,0.1174417,0.0002805027,0.00003033942,0.0009593145,0.002314831,0.0001474691,0.008425399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346623,"threshold_uncertainty_score":0.006309211,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}