{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":33,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":33,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"972172c7ee61","filters":{"venue":"Medicinal Chemistry"}},"results":[{"id":"W2128468782","doi":"10.2174/157340609788185909","title":"Possible Drug Candidates for Alzheimers Disease Deduced from Studying their Binding Interactions with α7 Nicotinic Acetylcholine Receptor","year":2009,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institute for Biological Sciences","funders":"National Cancer Institute","keywords":"Docking (animal); Chemistry; Nicotinic acetylcholine receptor; Hydrogen bond; Nicotinic agonist; Drug discovery; Molecule; Molecular dynamics; Biophysics; Receptor; Computational chemistry; Biochemistry; Biology; Medicine","authors":[{"name":"Ruo‐Xu Gu","is_ca":false},{"name":"Hui Gu","is_ca":false},{"name":"Zhi-Yuan Xie","is_ca":false},{"name":"Jingfang Wang","is_ca":true},{"name":"Hugo Arias‐Pulido","is_ca":false},{"name":"Dong‐Qing Wei","is_ca":false},{"name":"Kuo‐Chen Chou","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04208362176876451,"gpt":0.3208982408850127,"spread":0.2788146191162482,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339237,0.0003773903,0.0006520642,0.0004408012,0.0002037581,0.0002999536,0.0001789733,0.0002459457,0.004318051],"category_scores_gemma":[0.0001758748,0.0001460627,0.0003233505,0.0002776863,0.0001296951,0.0002268045,0.0001255977,0.0002075037,0.0004786055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001774794,"about_ca_system_score_gemma":0.0003380621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002901265,"about_ca_topic_score_gemma":0.0008557155,"domain_scores_codex":[0.9999648,0.00001037557,0.000002885973,0.000005974453,0.000008584035,0.000007330518],"domain_scores_gemma":[0.9999679,0.00001115979,0.000007642923,0.000001477372,0.000004764891,0.00000708559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005258389,0.001381991,0.01359757,0.002770136,0.0002880202,0.00528497,0.0002262415,0.02170634,0.707044,0.01149629,0.003074388,0.2278716],"study_design_scores_gemma":[0.004948846,0.01802688,0.05310638,0.0005894171,0.002962963,0.006293159,0.0008134343,0.06080123,0.774621,0.01174819,0.06590352,0.0001849324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9529687,0.02632873,0.006768072,0.0006360474,0.00006520788,0.0004103685,0.0009875597,0.0001870076,0.01164824],"genre_scores_gemma":[0.9660612,0.01389327,0.01429593,0.0002577209,0.0000337016,0.0001565733,0.001351625,0.00001034863,0.003939541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004318051,"threshold_uncertainty_score":0.01444536,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2046205615","doi":"10.2174/157340608784872235","title":"Truncation of the Krebs Cycle During Hypoglycemic Coma","year":2008,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Neurological Disorders and Treatments","field":"Neuroscience","cited_by":40,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Citric acid cycle; Tricarboxylic acid; Aminooxyacetic acid; Glutamate receptor; Biochemistry; Glutamine; Ketone bodies; Metabolism; Metabolic pathway; Biology; Chemistry; Amino acid","authors":[{"name":"Garnette R. Sutherland","is_ca":true},{"name":"Randy L. Tyson","is_ca":false},{"name":"Roland N. Auer","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02058573319759382,"gpt":0.2259523138490022,"spread":0.2053665806514084,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562904,0.000274832,0.0003618528,0.0002416308,0.0001893459,0.000304534,0.0001571038,0.0002021817,0.0008402314],"category_scores_gemma":[0.0003999932,0.0001101367,0.0001344853,0.0001818386,0.0004884136,0.0003539977,0.0004176885,0.0005480063,0.0002134681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003531622,"about_ca_system_score_gemma":0.0002734303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000524153,"about_ca_topic_score_gemma":0.000493486,"domain_scores_codex":[0.9999151,0.00001715786,0.00001011113,0.00001323757,0.00001702401,0.00002734186],"domain_scores_gemma":[0.9998192,0.00001384781,0.00008892888,0.00001610885,0.00002352707,0.0000384109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007353166,0.00009155305,0.008702472,0.0002925322,0.00005587161,0.002040918,0.0004509655,0.001791194,0.9488416,0.002606085,0.0005412838,0.0272323],"study_design_scores_gemma":[0.0001787412,0.005081165,0.138774,0.000143083,0.0001250649,0.007499716,0.0009583056,0.009312825,0.8161601,0.008247283,0.01344877,0.00007107047],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893249,0.003418368,0.004804241,0.0001582499,0.00005608796,0.00003221794,0.0001300793,0.0001419844,0.00193385],"genre_scores_gemma":[0.9978115,0.001091338,0.0005819893,0.00004074286,0.000006735666,0.0000145945,0.0001222178,0.000006712331,0.0003241293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008402314,"threshold_uncertainty_score":0.002810776,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2143000209","doi":"10.2174/157340606778250252","title":"A First QSAR Model for Galectin-3 Glycomimetic Inhibitors Based on 3D Docked Structures","year":2006,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Quantitative structure–activity relationship; Principal component analysis; Partial least squares regression; Molecular descriptor; Chemistry; Binding affinities; Artificial neural network; Artificial intelligence; Computational biology; Computer science; Stereochemistry; Machine learning; Biology; Biochemistry","authors":[{"name":"Suzanne Sirois","is_ca":true},{"name":"Denis Giguère","is_ca":false},{"name":"René Roy","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007768646001542558,"gpt":0.2239362804951727,"spread":0.2161676344936301,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000584184,0.0008310668,0.0009827806,0.0004031836,0.0001941232,0.0005564414,0.000632111,0.0006214538,0.001704905],"category_scores_gemma":[0.001356691,0.0002991902,0.001108568,0.0005080858,0.0002961804,0.0005277183,0.0003041203,0.0008258148,0.0004988113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006942843,"about_ca_system_score_gemma":0.0006560999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003388115,"about_ca_topic_score_gemma":0.002321372,"domain_scores_codex":[0.9997045,0.0001178013,0.00001503618,0.00004387942,0.00009167846,0.00002708158],"domain_scores_gemma":[0.9996238,0.000250775,0.00003805424,0.00001917929,0.00005950678,0.000008826035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006281721,0.0000323011,0.0004439653,0.00009497254,0.00004536341,0.00004662315,0.00002502218,0.9735141,0.006913727,0.002651223,0.0006233333,0.0155465],"study_design_scores_gemma":[0.00001115661,0.00006919649,0.000265484,0.000006443793,0.00001347446,0.0000238719,0.000004085146,0.9964192,0.001501727,0.0009579827,0.000719414,0.000007883326],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.08367647,0.001096943,0.9074433,0.0003981326,0.00006466775,0.0002299384,0.001403414,0.0008652391,0.004821877],"genre_scores_gemma":[0.8649214,0.001577925,0.1269597,0.0002185468,0.00005671535,0.000629868,0.001934035,0.0001174626,0.003584271],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003388115,"threshold_uncertainty_score":0.006736755,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2063369576","doi":"10.2174/1573406411208061133","title":"Identification of Small Molecule Sulfonic Acids as Ecto-5'-Nucleotidase Inhibitors","year":2012,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"5'-nucleotidase; Chemistry; Identification (biology); Small molecule; Molecule; Combinatorial chemistry; Computational biology; Biochemistry; Enzyme; Biology; Organic chemistry","authors":[{"name":"Aamer Saeed","is_ca":false},{"name":"Joanna Lecka","is_ca":false},{"name":"Jean Sévigny","is_ca":false},{"name":"Jamshed Iqbal","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01021076371940148,"gpt":0.2528994830052453,"spread":0.2426887192858439,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016398,0.0003376982,0.0003353255,0.0002401755,0.00008844357,0.0002095312,0.0001790787,0.000206493,0.001303519],"category_scores_gemma":[0.0001142423,0.000104061,0.0001872008,0.000181516,0.0001555553,0.0001410073,0.0001068972,0.0003016102,0.0002886585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423493,"about_ca_system_score_gemma":0.0002326986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005277339,"about_ca_topic_score_gemma":0.001626102,"domain_scores_codex":[0.9999329,0.00001662534,0.000005557007,0.000009556445,0.00001866593,0.00001666834],"domain_scores_gemma":[0.9999262,0.00001580523,0.00001661994,0.000003989175,0.00001624518,0.00002120366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002490452,0.00008739542,0.000461135,0.0001107155,0.00001611877,0.0001454728,0.00002204213,0.0003854984,0.988844,0.0001986056,0.00007480654,0.00940505],"study_design_scores_gemma":[0.0001397713,0.002614923,0.003799846,0.0000202354,0.00007005752,0.0005003918,0.00002737744,0.001074393,0.9840475,0.00006829303,0.007627533,0.000009825763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744174,0.01488991,0.006115656,0.0001559912,0.00003803723,0.0001769858,0.0003990917,0.00006838016,0.003738584],"genre_scores_gemma":[0.9796519,0.009621917,0.006592949,0.000079778,0.00003187377,0.00006086614,0.0007563173,0.00001027499,0.003194093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303519,"threshold_uncertainty_score":0.004360735,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2924765283","doi":"10.2174/1573406415666190319101329","title":"Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies","year":2019,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Laurentian University","funders":"National Research Foundation of Korea","keywords":"Tyrosinase; Kojic acid; Melanin; Chemistry; In vivo; Biochemistry; Arbutin; In vitro; Docking (animal); IC50; Enzyme; Stereochemistry; Biology","authors":[{"name":"Anser Ali","is_ca":false},{"name":"Zaman Ashraf","is_ca":false},{"name":"Muhammad Rafiq","is_ca":false},{"name":"Ajeet Kumar","is_ca":false},{"name":"Farukh Jabeen","is_ca":true},{"name":"Goon Joon Lee","is_ca":false},{"name":"Fahad Nazir","is_ca":false},{"name":"Mushtaq Ahmed","is_ca":false},{"name":"Myungchull Rhee","is_ca":false},{"name":"Eun Ha Choi","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01109787131742905,"gpt":0.2754495586456963,"spread":0.2643516873282672,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002613405,0.00089112,0.001165268,0.0003940946,0.0002421028,0.0006628222,0.000576924,0.0005258371,0.003498776],"category_scores_gemma":[0.0003105839,0.0002431719,0.001047558,0.000438272,0.0001494028,0.000385545,0.0002847334,0.0005325602,0.0005507699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003787332,"about_ca_system_score_gemma":0.000395578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002473209,"about_ca_topic_score_gemma":0.003745075,"domain_scores_codex":[0.9999338,0.00001491128,0.000003642195,0.00001543213,0.0000180645,0.00001394961],"domain_scores_gemma":[0.9999175,0.00003240039,0.00002003425,0.000004560935,0.00001496082,0.00001052047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00135802,0.0009871427,0.004100326,0.004126095,0.0006552608,0.001573825,0.00007577045,0.8242568,0.08526514,0.00578604,0.005477177,0.06633832],"study_design_scores_gemma":[0.0004291538,0.003105697,0.001816419,0.000135385,0.0006261364,0.0005018147,0.0001093611,0.9388667,0.03029302,0.00181068,0.02222918,0.00007641919],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8560564,0.05498433,0.05301101,0.0008593125,0.0002801819,0.0003421698,0.004825283,0.001091612,0.02854965],"genre_scores_gemma":[0.9392222,0.01378114,0.03835996,0.0002512861,0.00006289135,0.0002422127,0.002758332,0.00009381325,0.005228113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003498776,"threshold_uncertainty_score":0.0117045,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2147672878","doi":"10.2174/157340607779317625","title":"Biophysical Characterization of the Interaction of Endotoxins with Hemoglobins","year":2006,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network","funders":"","keywords":"Lipopolysaccharide; Bacterial outer membrane; Isothermal titration calorimetry; Immune system; Hemoglobin; Bacteria; Chemistry; Cytokine; Biochemistry; Cell biology; Microbiology; Biology; Immunology; Escherichia coli","authors":[{"name":"Jörg Howe","is_ca":false},{"name":"Malte U. Hammer","is_ca":false},{"name":"Christian Alexander","is_ca":false},{"name":"Manfred Rößle","is_ca":false},{"name":"K. Fournier","is_ca":false},{"name":"Jean‐Pierre Mach","is_ca":false},{"name":"Thierry Waelli","is_ca":false},{"name":"Reginald M. Gorczynski","is_ca":true},{"name":"Artur J. Ulmer","is_ca":false},{"name":"Ulrich Zähringer","is_ca":false},{"name":"Klaus Brandenburg","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003129646349729422,"gpt":0.1957003895090895,"spread":0.1925707431593601,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622316,0.0001259345,0.0001180262,0.0001173969,0.0001513448,0.0001575406,0.0001240342,0.0001652384,0.0005651496],"category_scores_gemma":[0.0004154162,0.00006477343,0.00008601656,0.000112413,0.0001510154,0.0001230636,0.0001131113,0.0003546746,0.0001246275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053173,"about_ca_system_score_gemma":0.00007670356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003226684,"about_ca_topic_score_gemma":0.0001427205,"domain_scores_codex":[0.999894,0.00002646508,0.000005568631,0.00001569165,0.00003483074,0.00002337041],"domain_scores_gemma":[0.9998234,0.00004838104,0.00004826831,0.00001079381,0.00003491922,0.00003428564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003151853,0.00001943852,0.0003287082,0.000009717176,0.000003505123,0.00002220835,0.00001888823,0.0001101996,0.9988249,0.00006724569,0.00003555772,0.0005280793],"study_design_scores_gemma":[0.00001094804,0.0002792909,0.0141576,0.000005986901,0.00001465783,0.0001901348,0.00007658156,0.006394886,0.9771906,0.0001110533,0.001557199,0.00001099854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960384,0.0003518391,0.002812651,0.00007973688,0.00001233911,0.000005694737,0.00009484226,0.00001552475,0.0005889892],"genre_scores_gemma":[0.9979063,0.0001979806,0.001148304,0.00004392326,0.000006887889,0.000009013916,0.0001932473,0.000006302794,0.0004881301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005651496,"threshold_uncertainty_score":0.0018906,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2108798400","doi":"10.2174/1573406053175238","title":"Selection of Molecular Descriptors with Artificial Intelligence for the Understanding of HIV-1 Protease Peptidomimetic Inhibitors-activity","year":2005,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":15,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Montreal General Hospital","funders":"","keywords":"Quantitative structure–activity relationship; Molecular descriptor; HIV-1 protease; Peptidomimetic; Feature selection; Protease; Artificial intelligence; Lipophilicity; Artificial neural network; Chemistry; Computational biology; Machine learning; Computer science; Stereochemistry; Biology; Biochemistry; Enzyme; Peptide","authors":[{"name":"Suzanne Sirois","is_ca":true},{"name":"C Tsoukas","is_ca":false},{"name":"Kuo‐Chen Chou","is_ca":false},{"name":"Dong‐Qing Wei","is_ca":false},{"name":"Colette Boucher","is_ca":false},{"name":"George Hatzakis","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04837339924905645,"gpt":0.2959517512888909,"spread":0.2475783520398344,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007249608,0.0005774318,0.0007567259,0.001105512,0.0001114835,0.0005074617,0.0002978346,0.0003667893,0.0004629452],"category_scores_gemma":[0.002129088,0.0001963642,0.0005142106,0.001088154,0.0002575075,0.0004732222,0.0002648869,0.0004370856,0.0001381726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003569448,"about_ca_system_score_gemma":0.0005079374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113568,"about_ca_topic_score_gemma":0.0009983139,"domain_scores_codex":[0.9996915,0.0001391082,0.00002562249,0.00003774773,0.00009101364,0.00001505005],"domain_scores_gemma":[0.9994699,0.0003612728,0.00006670621,0.0000260291,0.00006551795,0.00001056407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002217012,0.0002090361,0.005305877,0.0002331523,0.000150864,0.0001321541,0.00004011009,0.7817413,0.01925037,0.002335209,0.0004073484,0.1899729],"study_design_scores_gemma":[0.00001737765,0.0001316967,0.002099152,0.00001068187,0.00003360325,0.00003477062,0.00001103041,0.9916356,0.00405546,0.001470394,0.0004911829,0.00000901211],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3719942,0.00250027,0.6215057,0.0003539391,0.00003240061,0.0001581036,0.0002572069,0.0005013108,0.002696814],"genre_scores_gemma":[0.8708587,0.0009214614,0.127126,0.000055951,0.00002966535,0.0001422593,0.0003754242,0.00002518263,0.0004654129],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00113568,"threshold_uncertainty_score":0.003834009,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2041258384","doi":"10.2174/157340609787582945","title":"Synthesis and Hypoxia Selective Radiosensitization Potential of β-2-FAZA and β-3-FAZL: Fluorinated Azomycin β-Nucleosides","year":2009,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Mazandaran University of Medical Sciences; Canadian Institutes of Health Research; Ministry of Health and Medical Education","keywords":"Nitroimidazole; Nucleoside; Chemistry; Hypoxia (environmental); Stereochemistry; Combinatorial chemistry; Radiochemistry; Organic chemistry; Oxygen","authors":[{"name":"Piyush Kumar","is_ca":true},{"name":"Saeed Emami","is_ca":false},{"name":"Z. Kresolek","is_ca":false},{"name":"Jingyue Yang","is_ca":false},{"name":"Alexander McEwan","is_ca":false},{"name":"Leonard I. Wiebe","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00723283570263339,"gpt":0.2324197937480937,"spread":0.2251869580454604,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223113,0.000339747,0.0002158811,0.000152254,0.0001307798,0.000184706,0.0002094112,0.0003624572,0.0007071199],"category_scores_gemma":[0.0002166649,0.0001143702,0.0001630814,0.0001795929,0.000139735,0.00022466,0.0001186382,0.0003210727,0.0003908277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002065506,"about_ca_system_score_gemma":0.0001944807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005217454,"about_ca_topic_score_gemma":0.0007350126,"domain_scores_codex":[0.9999337,0.0000148457,0.000006170569,0.00001701466,0.00001551183,0.00001270186],"domain_scores_gemma":[0.9999124,0.00001981527,0.00002445474,0.00000937778,0.00001613201,0.00001793062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005129541,0.000008691271,0.00002772735,0.00004022515,0.000002771758,0.00004437681,0.00001814574,0.0001988171,0.997658,0.0001001191,0.00001766077,0.001832191],"study_design_scores_gemma":[0.000006428719,0.000133876,0.0002482213,0.000002247989,0.000005067671,0.00006408614,0.000003661448,0.0002222026,0.9973672,0.00001205717,0.001931044,0.000003916015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804283,0.003681423,0.0117847,0.00007722154,0.00002146468,0.0001175776,0.0007213081,0.0001023851,0.00306564],"genre_scores_gemma":[0.9758195,0.002468958,0.01795955,0.00004345851,0.0000118884,0.00009817785,0.0009226351,0.00004055255,0.002635268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007071199,"threshold_uncertainty_score":0.00236553,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2072271351","doi":"10.2174/157340606776930745","title":"In vitro Anti-Mycobacterial Activities of Various 2-Deoxyuridine, 2- Arabinouridine and 2-Arabinofluoro-2-deoxyuridine Analogues: Synthesis and Biological Studies","year":2006,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research","keywords":"In vitro; Tuberculosis; Deoxyuridine; Mycobacterium bovis; Chemistry; Mycobacterium tuberculosis; Mycobacterium; Microbiology; Medicine; Stereochemistry; Biology; Biochemistry; Pathology; DNA","authors":[{"name":"Rakesh Kumar","is_ca":true},{"name":"Dennis Kunimoto","is_ca":false},{"name":"Tracey Manning","is_ca":false},{"name":"Naveen C. Srivastav","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01899995177064992,"gpt":0.2419664298294068,"spread":0.2229664780587569,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003072503,0.0003948034,0.0003043935,0.0001710992,0.000111883,0.0001351973,0.0002208461,0.0002291457,0.001260028],"category_scores_gemma":[0.0002541801,0.0001514703,0.0001798341,0.0002300562,0.000131352,0.0001304262,0.00009133778,0.0002171942,0.0003094551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031289,"about_ca_system_score_gemma":0.0001308143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000355434,"about_ca_topic_score_gemma":0.0006027162,"domain_scores_codex":[0.9998603,0.00005848741,0.00001307521,0.00001681965,0.00003016523,0.00002109693],"domain_scores_gemma":[0.9998496,0.00006472866,0.00002656639,0.00001036047,0.00002495584,0.00002385123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003311395,0.00008549025,0.0001130465,0.0002183759,0.00001074614,0.00004134756,0.0000271108,0.0003054652,0.9951292,0.00003932515,0.00002723379,0.003671551],"study_design_scores_gemma":[0.00004345407,0.003621596,0.001277628,0.00001327102,0.00003130035,0.0001837395,0.00001118632,0.0003291453,0.9925125,0.00001666891,0.001955139,0.000004377645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657282,0.02923706,0.001939802,0.0000489933,0.00005169939,0.00005778202,0.0004948179,0.00003389016,0.002407695],"genre_scores_gemma":[0.9818511,0.0119356,0.003389297,0.00004397374,0.0000403962,0.00003273187,0.00107462,0.00001056514,0.001621746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260028,"threshold_uncertainty_score":0.00421524,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1989903543","doi":"10.2174/157340608786242089","title":"Hemoglobin Enhances the Biological Activity of Synthetic and Natural Bacterial (Endotoxic) Virulence Factors: A General Principle","year":2008,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network","funders":"","keywords":"Lipid A; Virulence; Biological activity; Virulence factor; Lipopolysaccharide; Hemoglobin; Lipopeptide; Cytokine; Microbiology; Biology; Tumor necrosis factor alpha; Chemistry; Biochemistry; Bacteria; Immunology; In vitro; Gene","authors":[{"name":"Jörg Howe","is_ca":false},{"name":"Walter Richter","is_ca":false},{"name":"Lynn D. Hawkins","is_ca":false},{"name":"Manfred Rößle","is_ca":false},{"name":"Christian Alexander","is_ca":false},{"name":"K. Fournier","is_ca":false},{"name":"J.-P. Mach","is_ca":false},{"name":"Thierry Waelli","is_ca":false},{"name":"Reginald M. Gorczynski","is_ca":true},{"name":"Artur J. Ulmer","is_ca":false},{"name":"Helmut Brade","is_ca":false},{"name":"Alla Zamyatina","is_ca":false},{"name":"Paul Kosma","is_ca":false},{"name":"Ernst Rietschel","is_ca":false},{"name":"Klaus Brandenburg","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02666443315769726,"gpt":0.2875841870441883,"spread":0.260919753886491,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342767,0.0003138474,0.0001690072,0.0001414615,0.00004348103,0.0001783305,0.0001048286,0.0002743291,0.0007194627],"category_scores_gemma":[0.0001874441,0.0000619579,0.0001500253,0.000085789,0.0001899946,0.0001365729,0.0001767912,0.0002407686,0.00009624695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007215891,"about_ca_system_score_gemma":0.00008321489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001054833,"about_ca_topic_score_gemma":0.00007265431,"domain_scores_codex":[0.9998156,0.0000792866,0.000009487947,0.00001924852,0.00004129576,0.00003505508],"domain_scores_gemma":[0.9997846,0.000087938,0.00004362906,0.00001851745,0.00002903078,0.00003622126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001982978,0.00003688951,0.0002850289,0.00006773099,0.000006660334,0.0000441995,0.00001401769,0.00004277728,0.9973478,0.0000528097,0.00001195408,0.001891744],"study_design_scores_gemma":[0.00002359933,0.001909902,0.008803624,0.00001074035,0.0000288876,0.0002338639,0.00002291478,0.0003893978,0.9870336,0.0000554123,0.001483571,0.0000043897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991867,0.004383747,0.002638764,0.00007594658,0.00001792896,0.00002998798,0.00007159986,0.0000220416,0.000892979],"genre_scores_gemma":[0.9966232,0.001084716,0.001536191,0.00006505119,0.00002647862,0.00001792169,0.00009450354,0.000005422114,0.0005464784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007194627,"threshold_uncertainty_score":0.002406836,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2046940454","doi":"10.2174/1573406053765477","title":"Investigation of Bioisosteric Effects on the Interaction of Substrates/ Inhibitors with the Methionyl-tRNA Synthetase from Escherichia coli","year":2005,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"","keywords":"Transfer RNA; Escherichia coli; Enzyme; Adenylate kinase; Aminoacyl tRNA synthetase; Biochemistry; Amino acid; Methionine; Chemistry; Biosynthesis; Amino Acyl-tRNA Synthetases; Stereochemistry; Biology; RNA; Gene","authors":[{"name":"Martha Vaughan","is_ca":true},{"name":"Peter B. Sampson","is_ca":false},{"name":"Elisabeth Daub","is_ca":true},{"name":"John F. Honek","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008598077768464404,"gpt":0.2180559068823793,"spread":0.2094578291139149,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002218276,0.0003703781,0.0003003207,0.0001189483,0.0000959075,0.0002482308,0.0003352923,0.0003554854,0.0006566456],"category_scores_gemma":[0.0004211142,0.0001485825,0.0001858467,0.0001719448,0.0001735589,0.0001774625,0.0001123105,0.0003799553,0.0002267211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739089,"about_ca_system_score_gemma":0.0001432519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007441403,"about_ca_topic_score_gemma":0.0005687878,"domain_scores_codex":[0.9997507,0.00007562896,0.00002143605,0.00003439784,0.00007035807,0.00004755914],"domain_scores_gemma":[0.9997094,0.0001388319,0.00006122533,0.00002396535,0.00004302099,0.00002352016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003428452,0.0001064867,0.0002831747,0.00005922811,0.00001559384,0.00005873979,0.0000258631,0.0003802427,0.9970674,0.00005004507,0.00002426469,0.001586238],"study_design_scores_gemma":[0.000007960271,0.0006403649,0.0009217491,0.000003583711,0.00001273204,0.00006104588,0.00001825241,0.0004552818,0.9974088,0.000006694595,0.0004598273,0.000003781736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970809,0.001231735,0.0005158616,0.00004162623,0.00001433707,0.00001514886,0.0000962659,0.00001607803,0.0009879872],"genre_scores_gemma":[0.9978833,0.0007628023,0.0006075295,0.00002295531,0.00000507882,0.0000094607,0.0001457613,0.000007908729,0.000555333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007441403,"threshold_uncertainty_score":0.00219667,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2326059217","doi":"10.4172/2161-0444.1000144","title":"Synthesis and Evaluation of Anticancer Activity of O-allylchalcone Derivatives","year":2013,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":10,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Agence Universitaire de la Francophonie; Université du Québec à Montréal","keywords":"Chemistry; Combinatorial chemistry; Pharmacology; Computational biology; Medicine; Biology","authors":[{"name":"Bathélémy Ngameni","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0238390609498234,"gpt":0.236698791187303,"spread":0.2128597302374796,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007817422,0.0003322623,0.0002329543,0.0003980734,0.0001180003,0.0001592465,0.0002287947,0.0001529429,0.001940322],"category_scores_gemma":[0.0001294673,0.0000682399,0.0001398397,0.000374429,0.0001403053,0.0001579026,0.0001215639,0.000198367,0.0003190253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000252743,"about_ca_system_score_gemma":0.0002123023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005944533,"about_ca_topic_score_gemma":0.001343635,"domain_scores_codex":[0.9999521,0.000009149592,0.000004934305,0.000008276016,0.00001354007,0.00001206241],"domain_scores_gemma":[0.9999102,0.00001092908,0.00001581716,0.00001023594,0.00002510765,0.0000275928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002700498,0.000136346,0.0004658668,0.0001700515,0.00001108665,0.0002368553,0.0000312353,0.0005154669,0.986562,0.000230653,0.0001248582,0.01124566],"study_design_scores_gemma":[0.00007315163,0.002804499,0.003713721,0.00001362629,0.00002594713,0.0002743714,0.0000285474,0.0006591079,0.9883128,0.00006836576,0.004015781,0.00001012861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879727,0.002912312,0.002911759,0.00006524759,0.00002360309,0.0001681881,0.0008061355,0.0001054261,0.005034603],"genre_scores_gemma":[0.9919053,0.002008549,0.002964168,0.0000385551,0.0000142798,0.00006287135,0.0007712425,0.00001435454,0.002220555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001940322,"threshold_uncertainty_score":0.006491005,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2050474231","doi":"10.2174/1573406411006030123","title":"Dimethyl-Carbamic Acid 2,3-Bis-Dimethylcarbamoyloxy-6-(4-Ethyl-Piperazine- 1-Carbonyl)-Phenyl Ester: A Novel Multi-Target Therapeutic Approach to Neuroprotection","year":2010,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre","funders":"National Institute on Aging","keywords":"Neuroprotection; Acetylcholinesterase; Pharmacology; Carbamic acid; In vivo; Mitochondrion; Antioxidant; Prodrug; Chemistry; Metabolite; Biochemistry; Biology; Enzyme","authors":[{"name":"Laurent Lecanu","is_ca":false},{"name":"Laurent Tillement","is_ca":false},{"name":"Althea McCourty","is_ca":false},{"name":"Georges Rammouz","is_ca":false},{"name":"Wenguo Yao","is_ca":false},{"name":"Janet Greeson","is_ca":false},{"name":"Vassilios Papadopoulos","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02796059915665003,"gpt":0.2899889554234634,"spread":0.2620283562668134,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263875,0.0004544101,0.0002453056,0.0001910267,0.0001201814,0.0001670939,0.00035955,0.0003290859,0.001273724],"category_scores_gemma":[0.00004941949,0.0001104159,0.0002213896,0.0001317788,0.0001283935,0.0002703758,0.0001764267,0.0004081021,0.0004800976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602326,"about_ca_system_score_gemma":0.0001812943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003708565,"about_ca_topic_score_gemma":0.0006023805,"domain_scores_codex":[0.9999392,0.00001007523,0.000004383799,0.00001363842,0.00001483644,0.00001791108],"domain_scores_gemma":[0.9999679,0.000002033813,0.000009976649,0.000002950363,0.00000669998,0.00001041417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001591685,0.00006204441,0.00006605815,0.0001126794,0.00001133723,0.0001150571,0.00001016612,0.0001373997,0.9911739,0.000196647,0.00008257292,0.007872929],"study_design_scores_gemma":[0.00005719046,0.001351514,0.0008980174,0.000007418015,0.00003393578,0.0005662385,0.00001025305,0.0005022915,0.9896671,0.00004439109,0.00685232,0.000009329883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9403665,0.02844501,0.02075585,0.0005578459,0.000149234,0.000217123,0.0004387122,0.0002706333,0.008799064],"genre_scores_gemma":[0.9759583,0.008755581,0.009384713,0.0001445256,0.00005041618,0.00007069551,0.0003106621,0.00001730483,0.005307807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273724,"threshold_uncertainty_score":0.004261017,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2119860611","doi":"10.2174/157340613804488323","title":"Synthesis and Opioid Activity of Novel 6-ketolevorphanol Derivatives","year":2012,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Agonist; Stereochemistry; Potency; Antagonist; Affinities; Opioid; Receptor; In vitro; Opioid receptor; Ring (chemistry); μ-opioid receptor; Pharmacology; Analgesic; Biochemistry; Medicine","authors":[{"name":"Zsuzsanna Gyulai","is_ca":false},{"name":"Antal Udvardy","is_ca":false},{"name":"Attila Bényei","is_ca":false},{"name":"Jakub Fichna","is_ca":true},{"name":"Katarzyna Gach","is_ca":false},{"name":"Martin Storr","is_ca":true},{"name":"Géza Tóth","is_ca":false},{"name":"Sándor Antus","is_ca":false},{"name":"Sándor Berényi","is_ca":false},{"name":"Anna Janecka","is_ca":false},{"name":"Attila Sipos","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04029656402345957,"gpt":0.274128388280647,"spread":0.2338318242571874,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005739088,0.0002540941,0.000156897,0.0001075578,0.00007016864,0.0001118488,0.0002001709,0.0001144868,0.001400809],"category_scores_gemma":[0.00006402385,0.00007300261,0.0001094555,0.00009698676,0.000103121,0.0001840066,0.0001089701,0.0002652978,0.0002389127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001304414,"about_ca_system_score_gemma":0.0001304981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000311968,"about_ca_topic_score_gemma":0.0005996573,"domain_scores_codex":[0.9999752,0.000004425721,0.000003240892,0.000004600898,0.000004904923,0.000007654051],"domain_scores_gemma":[0.9999617,0.000003987848,0.00001253661,0.000003258421,0.00000719975,0.00001135527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003822169,0.0000868341,0.0003199129,0.0002273085,0.00001588099,0.0003778946,0.00004934699,0.000715105,0.983557,0.0004925526,0.000110197,0.01366583],"study_design_scores_gemma":[0.0001327834,0.003570167,0.006724367,0.00003401057,0.00007643449,0.001163698,0.00008829808,0.001136278,0.9729934,0.0002428106,0.01380379,0.00003391305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869511,0.004887628,0.003626192,0.0001037419,0.00004166732,0.00005952821,0.0005145787,0.00003394812,0.003781649],"genre_scores_gemma":[0.9887397,0.004603908,0.003518955,0.00007682054,0.00002218254,0.00003769022,0.0005266573,0.000007148061,0.002466986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400809,"threshold_uncertainty_score":0.004686117,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4399095793","doi":"10.2174/0115734064304100240511112619","title":"In Silico Discovery and Predictive Modeling of Novel Acetylcholinesterase (AChE) Inhibitors for Alzheimer's Treatment","year":2024,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Memorial University of Newfoundland","funders":"King Saud University","keywords":"Galantamine; Donepezil; Memantine; Acetylcholinesterase; Rivastigmine; Ligand (biochemistry); Chemistry; Pharmacology; Enzyme; Medicine; Receptor; Disease; Dementia; Biochemistry; Internal medicine; NMDA receptor","authors":[{"name":"Humaera Noor Suha","is_ca":false},{"name":"Md Shamim Hossain","is_ca":false},{"name":"Shofiur Rahman","is_ca":false},{"name":"Abdullah N. Alodhayb","is_ca":false},{"name":"Md. Mainul Hossain","is_ca":false},{"name":"Sarkar M. A. Kawsar","is_ca":true},{"name":"Kabir M. Uddin","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04671790739302545,"gpt":0.3362745843194811,"spread":0.2895566769264556,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004141787,0.0007062989,0.0009428836,0.0006777421,0.0004082425,0.000887772,0.0008439167,0.001099775,0.002615504],"category_scores_gemma":[0.001192438,0.0004438909,0.0008084733,0.0004549376,0.0003390504,0.0003141201,0.0004014935,0.000556002,0.0002591822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006859658,"about_ca_system_score_gemma":0.001443861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01064816,"about_ca_topic_score_gemma":0.01049325,"domain_scores_codex":[0.9998977,0.00004074573,0.000004885477,0.00001203706,0.00002475933,0.00001975522],"domain_scores_gemma":[0.9995205,0.0003527988,0.00003943094,0.00001200245,0.00004753056,0.00002768361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005243549,0.00004189694,0.0008081744,0.00003905072,0.00002729402,0.00005377494,0.000007861833,0.9960062,0.0002817412,0.0007778259,0.000277623,0.001626208],"study_design_scores_gemma":[0.00001056581,0.00001634319,0.00007583413,0.000004318606,0.000007150807,0.000005034505,0.000006010906,0.9993512,0.0001149706,0.0002585179,0.0001489358,0.000001170381],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8382497,0.003137614,0.1169323,0.002010677,0.0002331206,0.0002514182,0.002607387,0.0009781027,0.0355996],"genre_scores_gemma":[0.96903,0.0005811207,0.02662269,0.0001751837,0.00003014983,0.0001872945,0.0009173715,0.00004848438,0.002407696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01064816,"threshold_uncertainty_score":0.02117234,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2046220489","doi":"10.2174/157340606776056214","title":"Drug Evolution Concept in Drug Design: 2. Chimera Method","year":2006,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":7,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Biotechnology Research Institute; National Research Council Canada","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Drug; Drug discovery; Chimera (genetics); Computational biology; Computer science; Combinatorial chemistry; Chemistry; Biology; Bioinformatics; Pharmacology; Genetics","authors":[{"name":"Gheorghe Roman","is_ca":false},{"name":"T. Popek","is_ca":false},{"name":"Carmen Lazar","is_ca":false},{"name":"Taira Kiyota","is_ca":false},{"name":"Alicja Kluczyk","is_ca":false},{"name":"Y. Konishi","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01091555782630056,"gpt":0.2855292459592411,"spread":0.2746136881329406,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001617373,0.0005776676,0.0009654757,0.0009070475,0.0003783056,0.001054935,0.001162605,0.001128998,0.003134137],"category_scores_gemma":[0.001719558,0.0004248579,0.001251406,0.0008459867,0.001260749,0.001106656,0.001236693,0.001651716,0.000975738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001067958,"about_ca_system_score_gemma":0.001275513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007988837,"about_ca_topic_score_gemma":0.0004806707,"domain_scores_codex":[0.999227,0.0003836307,0.00003631752,0.00009322492,0.0002178611,0.00004186912],"domain_scores_gemma":[0.9996508,0.0001860759,0.00003076189,0.00005531361,0.00004791804,0.00002908877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002086545,0.00008795021,0.0005395288,0.0005464217,0.0001571355,0.0002239541,0.0001572211,0.1603845,0.01335126,0.6622669,0.004169757,0.1579067],"study_design_scores_gemma":[0.0001964026,0.0001837408,0.0001960953,0.0001192843,0.00008924084,0.0007414376,0.00003186778,0.7172674,0.0117023,0.1814954,0.08790702,0.0000698068],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.002915197,0.002138444,0.9872274,0.0005240385,0.00007595785,0.0001026151,0.00007109198,0.0004729735,0.006472228],"genre_scores_gemma":[0.08105963,0.00274059,0.9109434,0.0004264562,0.00006458502,0.0005006021,0.0001605163,0.0001856712,0.003918537],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003134137,"threshold_uncertainty_score":0.0104847,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2159358920","doi":"10.2174/1573406053402488","title":"Synthesis of A/B-Ring Partial Analogs of Bruceantin as Potential Antimalarial Agents","year":2005,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Multicomponent Synthesis of Heterocycles","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"U.S. Public Health Service; U.S. Department of Veterans Affairs","keywords":"Moiety; Bioassay; Ring (chemistry); Natural product; Chemistry; Stereochemistry; Combinatorial chemistry; Antimalarial Agent; Biology; Organic chemistry; Plasmodium falciparum; Malaria","authors":[{"name":"Zhikai Guo","is_ca":false},{"name":"Suryanarayana Vangapandu","is_ca":true},{"name":"Alison Nimrod","is_ca":false},{"name":"Larry Walker","is_ca":true},{"name":"Robert D. Sindelar","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01358585580006448,"gpt":0.2568792762812702,"spread":0.2432934204812057,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630548,0.0002988663,0.0002470762,0.0003109278,0.0001483419,0.0001754765,0.0003572241,0.0002030512,0.003291113],"category_scores_gemma":[0.0001485477,0.0001392595,0.0001790401,0.0002292386,0.0001284848,0.0002235265,0.0002215059,0.0003146317,0.0007053004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001774293,"about_ca_system_score_gemma":0.0002194527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002116318,"about_ca_topic_score_gemma":0.0005624732,"domain_scores_codex":[0.9999354,0.00001419999,0.000009202679,0.00001323335,0.00001398577,0.00001408942],"domain_scores_gemma":[0.9999155,0.00001200513,0.00001979671,0.00001230378,0.00001463177,0.00002580161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002392224,0.0001456508,0.0001777728,0.0002082021,0.00002125012,0.0001439998,0.00003091798,0.001511527,0.978028,0.0008420966,0.00018986,0.01846148],"study_design_scores_gemma":[0.0003171135,0.008070106,0.002833641,0.00004043628,0.00009354967,0.0007201792,0.00003627676,0.002661166,0.9705658,0.0004571714,0.01418172,0.00002281051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667972,0.004483743,0.01369899,0.0001279148,0.00006840452,0.0005017755,0.0009112557,0.0001935846,0.01321718],"genre_scores_gemma":[0.9741462,0.003213321,0.01693151,0.0001347503,0.0000353784,0.0002117033,0.0007722878,0.00002622809,0.004528447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003291113,"threshold_uncertainty_score":0.01100981,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2219037964","doi":"10.2174/1573406411666150504123750","title":"Exploring the Synthesis and Anticancer Potential of L-Tyrosine-Platinum(II) Hybrid Molecules","year":2015,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Platinum; Tyrosine; Molecule; Chemistry; Combinatorial chemistry; Biochemistry; Organic chemistry; Catalysis","authors":[{"name":"Caroline Descôteaux","is_ca":false},{"name":"Kevin Brasseur","is_ca":false},{"name":"Valérie Leblanc","is_ca":false},{"name":"Éric Asselin","is_ca":false},{"name":"Gervais Bérubé","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09986703246077945,"gpt":0.2616403200809092,"spread":0.1617732876201298,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008877827,0.0002168139,0.0001931152,0.0001576174,0.0001061815,0.0002458596,0.0002529296,0.0002848051,0.0007823715],"category_scores_gemma":[0.0001009851,0.0001352672,0.0001792709,0.0001839509,0.0001251908,0.0002698741,0.0002132768,0.0002723072,0.0002509326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149308,"about_ca_system_score_gemma":0.0001068579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002087483,"about_ca_topic_score_gemma":0.0003584971,"domain_scores_codex":[0.9999464,0.000008006678,0.000004538085,0.00001537567,0.00001357881,0.00001218238],"domain_scores_gemma":[0.9999663,0.000005767532,0.00001078166,0.000004011982,0.000004828789,0.000008280193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006917813,0.00002944333,0.0001379586,0.0001237165,0.00001323905,0.0001218201,0.00003496042,0.0005234943,0.9929793,0.000492811,0.00003562877,0.005438384],"study_design_scores_gemma":[0.00001836359,0.0005085142,0.0006722103,0.000005687425,0.00002396416,0.0002350811,0.00001803493,0.0008946054,0.9937724,0.00006771259,0.0037743,0.000009113268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821752,0.00310106,0.01136042,0.00008141444,0.00002097689,0.00005348412,0.0001249521,0.00007919607,0.00300336],"genre_scores_gemma":[0.9868528,0.00120462,0.01008482,0.0000364342,0.000006091264,0.00003686636,0.0001042563,0.0000126288,0.001661433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007823715,"threshold_uncertainty_score":0.0026173,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2895849502","doi":"10.2174/1573406414666181015142633","title":"Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells","year":2018,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Conjugated system; Colorectal cancer; Chemistry; Cancer research; Cancer; Pharmacology; Medicine; Internal medicine; Organic chemistry","authors":[{"name":"Swagatika Das","is_ca":true},{"name":"Halise İnci Gül","is_ca":true},{"name":"Umashankar Das","is_ca":true},{"name":"Jan Balzarini","is_ca":false},{"name":"Stephen G. Dimmock","is_ca":false},{"name":"Jonathan R. Dimmock","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01131998774561275,"gpt":0.2475967943932414,"spread":0.2362768066476287,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008908441,0.0003080325,0.000158001,0.0001825477,0.0001076881,0.0001280394,0.0001222417,0.0001296704,0.001225804],"category_scores_gemma":[0.00008023997,0.00006962488,0.0001474919,0.0001918057,0.0001103439,0.0001376011,0.0001120398,0.0002132111,0.0001889503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001278044,"about_ca_system_score_gemma":0.0001614503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004993594,"about_ca_topic_score_gemma":0.001112668,"domain_scores_codex":[0.999965,0.000006870773,0.000003706822,0.000006775207,0.000008386179,0.00000939711],"domain_scores_gemma":[0.9999462,0.000008470127,0.00001470257,0.000004900376,0.00001293995,0.00001268934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003552122,0.00008055896,0.000462761,0.0002586992,0.0000118175,0.0001758617,0.00006554471,0.0007789281,0.9898817,0.0002423262,0.0001235207,0.007563031],"study_design_scores_gemma":[0.00005864469,0.003963186,0.004589483,0.00002497558,0.00005458644,0.0005151202,0.00005790511,0.0007713579,0.9816065,0.00007290012,0.008271521,0.00001389142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915892,0.003736487,0.001454331,0.00006341771,0.00001990302,0.0000415143,0.0003472462,0.00004056582,0.00270728],"genre_scores_gemma":[0.9928904,0.002778696,0.002033598,0.00002857288,0.000007681938,0.0000291839,0.0003512787,0.000007495861,0.001873031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225804,"threshold_uncertainty_score":0.00410068,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2950192587","doi":"10.2174/1573406415666190614095821","title":"Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold","year":2020,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"Higher Education Commision, Pakistan; Crohn's and Colitis Canada","keywords":"Nucleoside; Nucleotide; Nucleoside triphosphate; Biochemistry; Chemistry; Extracellular; Nucleoside-diphosphate kinase; IC50; Adenosine triphosphate; Enzyme; In vitro","authors":[{"name":"Saira Afzal","is_ca":false},{"name":"Sumera Zaib","is_ca":false},{"name":"Behzad Jafari","is_ca":false},{"name":"Peter Langer","is_ca":false},{"name":"Joanna Lecka","is_ca":true},{"name":"Jean Sévigny","is_ca":true},{"name":"Jamshed Iqbal","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007962769240274357,"gpt":0.2104557478857081,"spread":0.2024929786454337,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226566,0.0005704174,0.0003311697,0.0002440554,0.0001093219,0.0001672533,0.0003523017,0.0002836388,0.001254014],"category_scores_gemma":[0.0001003092,0.0001284503,0.0001941537,0.0002024195,0.0001422998,0.0001775922,0.0001479788,0.0005088077,0.0003306977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002709758,"about_ca_system_score_gemma":0.0002253089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008731688,"about_ca_topic_score_gemma":0.002256989,"domain_scores_codex":[0.9999368,0.000009946652,0.000004870692,0.00001472012,0.00001377636,0.00001985328],"domain_scores_gemma":[0.999959,0.000006568327,0.00001192785,0.000003482515,0.000008166234,0.00001077791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007051141,0.0002079929,0.0002838261,0.0003971914,0.00002855658,0.0002973629,0.00003887211,0.0008224577,0.9793963,0.0003863966,0.0008255719,0.01661026],"study_design_scores_gemma":[0.0005314834,0.004532715,0.004385466,0.00005526979,0.0001130013,0.001419837,0.00003977678,0.001703618,0.9578223,0.0001097533,0.02925322,0.00003350723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930047,0.04521183,0.01025886,0.0003580589,0.0002534517,0.0003267556,0.001542317,0.000360013,0.01164179],"genre_scores_gemma":[0.9703655,0.01480452,0.00644575,0.0001663054,0.00002989652,0.0001561109,0.001402027,0.00001666312,0.006613317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254014,"threshold_uncertainty_score":0.004195094,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2464355131","doi":"10.2174/1573406412666160710210907","title":"Effect of O6-Substituted Guanine Analogs on O6-methylguanine DNA-methyltransferase Expression and Glioblastoma Cells Viability","year":2016,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Moncton","funders":"","keywords":"Guanine; Glioblastoma; Methyltransferase; O-6-methylguanine-DNA methyltransferase; DNA methyltransferase; Chemistry; Cancer research; DNA; Temozolomide; Viability assay; Molecular biology; Biology; Biochemistry; In vitro; Methylation; Gene; Nucleotide","authors":[{"name":"Marc Cormier","is_ca":false},{"name":"Véronique Leblanc","is_ca":false},{"name":"Pier Morin","is_ca":false},{"name":"Mohamed Touaibia","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004965127334218911,"gpt":0.2497871727030658,"spread":0.2448220453688469,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004668027,0.0002628468,0.0001380945,0.0001094582,0.00005750598,0.00008739468,0.0001403172,0.0001291361,0.0009113008],"category_scores_gemma":[0.00007540135,0.00005102764,0.0001192197,0.0001007196,0.00006741207,0.00008151855,0.00008787469,0.0001586497,0.0001313992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001097708,"about_ca_system_score_gemma":0.00009929882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000623113,"about_ca_topic_score_gemma":0.0009147631,"domain_scores_codex":[0.9999707,0.000005996882,0.00000203065,0.000005402279,0.000008277686,0.000007646895],"domain_scores_gemma":[0.9999663,0.000006125061,0.00001220251,0.000002455228,0.000005279825,0.000007765698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008851901,0.0002087626,0.0008623533,0.0001727365,0.00002487283,0.0001251035,0.00002517378,0.002196756,0.9858822,0.0001343914,0.0001255989,0.009356894],"study_design_scores_gemma":[0.00006223247,0.004471104,0.003476784,0.00001462129,0.00005269728,0.0001480269,0.00002176341,0.002055693,0.9870325,0.00003708007,0.00261712,0.00001026718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968892,0.001614599,0.0002759111,0.00002387307,0.00001078134,0.00001217098,0.0001489914,0.00002104343,0.001003468],"genre_scores_gemma":[0.997456,0.001407408,0.000417152,0.00001616074,0.000002695312,0.000009714276,0.0001742443,0.000003910571,0.0005125463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009113008,"threshold_uncertainty_score":0.003048599,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2166535645","doi":"10.2174/1573406411666150212120628","title":"New Testosterone Derivatives as Semi-Synthetic Anticancer Agents Against Prostate Cancer: Synthesis and Preliminary Biological Evaluation","year":2015,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Cyproterone acetate; Prostate cancer; Antiandrogen; Testosterone (patch); Medicine; Abiraterone acetate; LNCaP; Bicalutamide; Androgen; Hormone; Pharmacology; Cancer; Internal medicine; Oncology; Androgen deprivation therapy; Androgen receptor","authors":[{"name":"Nathalie Morin","is_ca":false},{"name":"Julie Bruneau","is_ca":false},{"name":"Sébastien Fortin","is_ca":false},{"name":"Kevin Brasseur","is_ca":false},{"name":"Valérie Leblanc","is_ca":false},{"name":"Éric Asselin","is_ca":false},{"name":"Gervais Bérubé","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.08506915519158377,"gpt":0.3664941828855822,"spread":0.2814250276939985,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135034,0.0002792439,0.0002197375,0.0001698716,0.00009941962,0.0001407924,0.0001698316,0.0001537584,0.001706523],"category_scores_gemma":[0.00009120419,0.00008135608,0.0001989965,0.0001895422,0.0001057536,0.0001838848,0.0001036804,0.0002901691,0.0004614594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001083605,"about_ca_system_score_gemma":0.0001941632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002726034,"about_ca_topic_score_gemma":0.0005633985,"domain_scores_codex":[0.9999511,0.000009580674,0.000004699716,0.000006621154,0.00001840522,0.000009674573],"domain_scores_gemma":[0.999966,0.000004236413,0.000007210177,0.000002423149,0.000008104765,0.00001209972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003615851,0.0002551012,0.0002071335,0.001562397,0.00003003281,0.0003452948,0.0001166713,0.00156586,0.9690331,0.001338809,0.0005957648,0.02458832],"study_design_scores_gemma":[0.0001234512,0.007107451,0.001988963,0.00006938745,0.00007150687,0.000649888,0.00006823109,0.001129353,0.9517504,0.0002245614,0.03678346,0.00003338263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8681489,0.0915457,0.02203488,0.0002870231,0.000342291,0.0005239418,0.002017133,0.0002116757,0.0148885],"genre_scores_gemma":[0.9425705,0.03725006,0.01208992,0.00014121,0.00009213224,0.0001237959,0.0009663044,0.00002180556,0.006744227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706523,"threshold_uncertainty_score":0.005708873,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2016806277","doi":"10.2174/157340607782360335","title":"Design and Synthesis of New N-OMe Fluoro-Indole Melatoninergics","year":2007,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Women's Health Research Institute","funders":"National and Kapodistrian University of Athens; Wellcome Trust","keywords":"Xenopus; Indole test; Stereochemistry; Agonist; Melanophore; Agonistic behaviour; Partial agonist; Antagonist; Chemistry; Potency; Pharmacology; Biology; Receptor; In vitro; Biochemistry; Medicine; Gene; Genetics","authors":[{"name":"Andrew Tsotinis","is_ca":false},{"name":"J. Gourgourinis","is_ca":false},{"name":"Andreas Eleutheriades","is_ca":false},{"name":"Kathryn Davidson","is_ca":false},{"name":"David Sugden","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06996949263559149,"gpt":0.3894309356773196,"spread":0.3194614430417281,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533844,0.0002412542,0.0002591311,0.0001701193,0.0001256005,0.0001658932,0.0003570464,0.0002201277,0.001597642],"category_scores_gemma":[0.0001267221,0.0001310683,0.0002090572,0.0001063755,0.0001257929,0.0001675516,0.0001413166,0.0003302355,0.000428174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187825,"about_ca_system_score_gemma":0.0001448761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003487141,"about_ca_topic_score_gemma":0.0009258849,"domain_scores_codex":[0.9999434,0.000008574997,0.000006121773,0.00001152317,0.00001240432,0.00001799325],"domain_scores_gemma":[0.9999459,0.000006144741,0.00001632809,0.000003874715,0.000008411682,0.00001936301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000212787,0.0001295672,0.0001639302,0.0002479856,0.00001700142,0.0002798252,0.00005773098,0.001045408,0.9842772,0.0008169354,0.0001844091,0.01256708],"study_design_scores_gemma":[0.0002443828,0.00406873,0.00311083,0.00004725777,0.00006926629,0.0007050566,0.00005609078,0.001951156,0.9585032,0.0002223811,0.03098216,0.00003953998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571739,0.007394099,0.02092989,0.0001843307,0.0001479881,0.0004215653,0.0007306937,0.0002126714,0.01280482],"genre_scores_gemma":[0.975199,0.003737066,0.01410902,0.0001614895,0.00004013981,0.0001463363,0.0004893825,0.00001980522,0.00609785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597642,"threshold_uncertainty_score":0.005344629,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2096235252","doi":"10.2174/1573406411309060009","title":"Effects of Biphenyl Sulfonylamino Methyl Bisphosphonic Acids on Porphyromonas Gingivalis and Cytokine Secretion by Oral Epithelial Cells","year":2013,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Bone health and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Porphyromonas gingivalis; Secretion; Periodontitis; Bisphosphonate; Cytokine; Lipopolysaccharide; Chemistry; Pharmacology; Internal medicine; Medicine; Microbiology; Biology; Osteoporosis","authors":[{"name":"Леи Жао","is_ca":false},{"name":"Annie Marquis","is_ca":false},{"name":"Vu Dang La","is_ca":false},{"name":"Mariangela Agamennone","is_ca":false},{"name":"Fulvio Loiodice","is_ca":false},{"name":"Paolo Tortorella","is_ca":false},{"name":"Daniel Grenier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005732241333244596,"gpt":0.2377841309868152,"spread":0.2320518896535706,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154621,0.0003991577,0.0002099291,0.000149846,0.0001302882,0.000174684,0.0001179537,0.0002698671,0.0009226578],"category_scores_gemma":[0.0001232879,0.00008717618,0.0001759694,0.0001823308,0.0001379782,0.00010728,0.0001441922,0.0002747476,0.0002236849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001124728,"about_ca_system_score_gemma":0.0002628238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001420143,"about_ca_topic_score_gemma":0.001811117,"domain_scores_codex":[0.9998447,0.00004768997,0.00001853897,0.00001597813,0.00003828278,0.00003476398],"domain_scores_gemma":[0.9999037,0.00002411542,0.00002881601,0.000008442122,0.00001656068,0.00001833891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003830899,0.00005011334,0.000150916,0.00007155993,0.000003551829,0.00003319557,0.00001557662,0.00004654065,0.9975702,0.00001991722,0.00001755276,0.001637751],"study_design_scores_gemma":[0.0000712445,0.002853326,0.00917444,0.00001629871,0.00002604591,0.0001170641,0.00008445347,0.0004381604,0.9847659,0.00003219444,0.002412782,0.000008051028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993958,0.004213293,0.0004329373,0.0001036232,0.00005161653,0.00002572281,0.0002211784,0.0000187981,0.0009747929],"genre_scores_gemma":[0.9934675,0.00321307,0.001283161,0.0001252099,0.00003771251,0.00004613954,0.0002684537,0.000004498198,0.001554438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420143,"threshold_uncertainty_score":0.003086567,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1967291354","doi":"10.2174/15734064113099990031","title":"Synthesis and Biological Activities of 2,6-Dihydroxy-4-Isopentenyloxychalcone as an Antimicrobial and Anti-Inflammatory Compound","year":2014,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Antimicrobial; Anti-inflammatory; Microbiology; Chemistry; Combinatorial chemistry; Traditional medicine; Pharmacology; Biology; Medicine","authors":[{"name":"Laetitia Bonifait","is_ca":false},{"name":"Леи Жао","is_ca":false},{"name":"Jabrane Azelmat","is_ca":false},{"name":"Salvatore Genovese","is_ca":false},{"name":"Francesco Epifano","is_ca":false},{"name":"Daniel Grenier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0142221829509942,"gpt":0.2471437279702287,"spread":0.2329215450192345,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009028634,0.0003150555,0.0001946728,0.0003679666,0.000139656,0.0001287186,0.0001846828,0.0002419748,0.001316027],"category_scores_gemma":[0.00008079664,0.00006002475,0.000166335,0.0002716563,0.0001172109,0.0001950754,0.0001387896,0.0001968448,0.0003034912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001553502,"about_ca_system_score_gemma":0.0003323152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004083513,"about_ca_topic_score_gemma":0.0007427998,"domain_scores_codex":[0.9999508,0.00001146195,0.000005072596,0.000008195664,0.0000103213,0.00001404733],"domain_scores_gemma":[0.9999452,0.000007061367,0.00001026262,0.000006895988,0.00001040267,0.00002029381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001696649,0.0001070125,0.0002036324,0.0002388992,0.000009095186,0.0003380876,0.00003220878,0.0004688651,0.9877598,0.0002918527,0.0000910736,0.01028987],"study_design_scores_gemma":[0.00005706359,0.001361505,0.003251905,0.00002187347,0.00002838044,0.0004265273,0.00003281994,0.0004392499,0.9882442,0.0001381771,0.005983283,0.00001501833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816413,0.007926196,0.00455791,0.000170241,0.00005487498,0.0001600452,0.0007700199,0.00005994737,0.004659399],"genre_scores_gemma":[0.9897724,0.003143005,0.004253453,0.00006266524,0.00001956471,0.00003715687,0.0004705347,0.000008087817,0.002233248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316027,"threshold_uncertainty_score":0.004402578,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2160401835","doi":"10.2174/157340608786241981","title":"A Comparison of the Biological Properties of Small Molecular Weight Agonists and Antagonists of CD200:CD200R Interactions","year":2008,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Mediator; Effector; Immunology; Myeloid; Receptor; Rodent; Biology; Mast cell; Small molecule; Disease; Cancer research; Medicine; Pharmacology; Cell biology; Internal medicine; Genetics","authors":[{"name":"Reg Gorczynski","is_ca":true},{"name":"Ivo Boudakov","is_ca":false},{"name":"Ismat Khatri","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09635788280535086,"gpt":0.2909793321727891,"spread":0.1946214493674382,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181737,0.0002642144,0.0003647034,0.0002871359,0.00009942483,0.0002137292,0.0001438265,0.0002653327,0.002157484],"category_scores_gemma":[0.0002950536,0.00008919917,0.0002109152,0.0001519818,0.0001504882,0.0002715396,0.00007548149,0.0004814378,0.0003946352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008160005,"about_ca_system_score_gemma":0.0001119458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009857737,"about_ca_topic_score_gemma":0.0001934696,"domain_scores_codex":[0.9999328,0.00001846545,0.000008259976,0.000008747585,0.00001449985,0.00001728891],"domain_scores_gemma":[0.9998332,0.00007760427,0.00001976026,0.00001559999,0.00001817731,0.00003555982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008227384,0.0002631544,0.0001864806,0.0001579052,0.00003427926,0.00007056976,0.00002674672,0.0002297634,0.9812118,0.0001882747,0.0001261613,0.01668214],"study_design_scores_gemma":[0.0002767745,0.02540926,0.008164394,0.00002323328,0.0001842273,0.001116397,0.00006712542,0.0009189968,0.9555719,0.0003123321,0.007930025,0.00002539827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825271,0.01019934,0.001791262,0.0001510985,0.00007215354,0.00008365447,0.000325127,0.0000473277,0.004802966],"genre_scores_gemma":[0.9876679,0.006561002,0.0023183,0.0002064837,0.00006939361,0.00007846622,0.0007310401,0.00001456228,0.002352852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157484,"threshold_uncertainty_score":0.007217467,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3088104678","doi":"10.2174/1573406416666200925141703","title":"Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer","year":2020,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Higher Education Commision, Pakistan; Crohn's and Colitis Canada","keywords":"HeLa; Cytotoxicity; Cytotoxic T cell; MTT assay; Cell culture; Molecular biology; Western blot; Nucleotidase; Adenosine; Enzyme; Chemistry; Adenosine monophosphate; Dephosphorylation; Apoptosis; Cell; Biochemistry; Biology; Phosphatase; In vitro; Gene","authors":[{"name":"Jamshed Iqbal","is_ca":false},{"name":"Ayesha Basharat","is_ca":false},{"name":"Sehrish Bano","is_ca":false},{"name":"Syed Mobasher Ali Abid","is_ca":false},{"name":"Julie Pelletier","is_ca":true},{"name":"Jean Sévigny","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01006253617763177,"gpt":0.2641232889082271,"spread":0.2540607527305953,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008628084,0.000241079,0.0002292967,0.0003380123,0.0001823318,0.0001473682,0.0001353608,0.0001863277,0.0008895671],"category_scores_gemma":[0.0000939399,0.00008486185,0.0001900016,0.0002599531,0.00010513,0.0001078258,0.00008932906,0.0002315738,0.000168974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003310671,"about_ca_system_score_gemma":0.0002942824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213255,"about_ca_topic_score_gemma":0.002483292,"domain_scores_codex":[0.9999341,0.00000863914,0.000004587167,0.00001179874,0.00002403238,0.0000168139],"domain_scores_gemma":[0.999952,0.00000672843,0.00001332968,0.000003501045,0.00001647685,0.000007993654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001568993,0.00003990546,0.0003600448,0.0001471991,0.000009373601,0.00007878806,0.00001463087,0.0001145958,0.9905923,0.00006587404,0.0001050112,0.008315412],"study_design_scores_gemma":[0.00002443154,0.001043043,0.004007004,0.00001649411,0.00005248805,0.000412619,0.00003164379,0.0005087503,0.9876893,0.00002965046,0.006179542,0.000004905798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690832,0.02318464,0.002917779,0.0002489004,0.00004548702,0.0001367501,0.0005405353,0.00009000498,0.003752719],"genre_scores_gemma":[0.9749145,0.01465049,0.005464718,0.000133438,0.00003279329,0.0001038563,0.0008464812,0.00001415124,0.003839627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213255,"threshold_uncertainty_score":0.002975881,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2015700611","doi":"10.2174/157340607781745438","title":"Structure Function Analysis of West Nile Virus RNA Dependent RNA Polymerase: Molecular Model and Implications for Drug Design","year":2007,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true},"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"","keywords":"RNA polymerase; RNA-dependent RNA polymerase; Polymerase; Biology; RNA; Virology; Homology modeling; Enzyme; Genetics; Biochemistry; Gene","authors":[{"name":"Arezki Azzi","is_ca":true},{"name":"Sheng‐Xiang Lin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00963457973524368,"gpt":0.2720095002622122,"spread":0.2623749205269685,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007255953,0.000500041,0.0005863922,0.0002128358,0.0003101504,0.0004434287,0.000539876,0.0005840393,0.002455347],"category_scores_gemma":[0.0001238052,0.0001633661,0.0003922489,0.0002131069,0.0002355927,0.0004330705,0.0001152823,0.0003606205,0.000566819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005503136,"about_ca_system_score_gemma":0.0004548311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630442,"about_ca_topic_score_gemma":0.0007929878,"domain_scores_codex":[0.9999741,0.000006383311,0.0000013244,0.000006185501,0.000007442874,0.000004557563],"domain_scores_gemma":[0.9999788,0.000006980865,0.000004253106,0.000001835249,0.000004353625,0.000003651206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004050507,0.0001833354,0.00127051,0.0003760942,0.00005633758,0.0005069359,0.00009708173,0.7681849,0.1357102,0.06927528,0.001644894,0.02228937],"study_design_scores_gemma":[0.00004854241,0.0001573332,0.0002719483,0.0000103247,0.00001621308,0.00007879617,0.00002457308,0.9783168,0.007832241,0.01078847,0.002444139,0.00001051279],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7202826,0.007664234,0.2418836,0.002490479,0.0001580406,0.0001328626,0.001126183,0.0009443447,0.02531764],"genre_scores_gemma":[0.9514631,0.003891703,0.04006948,0.00009862833,0.00003069341,0.0001528767,0.0009807218,0.00005239256,0.003260212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002455347,"threshold_uncertainty_score":0.008213997,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2282635632","doi":"10.2174/1573406411666150430121640","title":"Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum","year":2015,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Antibacterial activity; Microbiology; Lipopolysaccharide; Porphyromonas gingivalis; Bacteria; Biology; Chemistry; Immunology","authors":[{"name":"Jabrane Azelmat","is_ca":false},{"name":"Serena Fiorito","is_ca":false},{"name":"Salvatore Genovese","is_ca":false},{"name":"Francesco Epifano","is_ca":false},{"name":"Daniel Grenier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009743374843910604,"gpt":0.2150927158725886,"spread":0.205349341028678,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007672843,0.0003297463,0.0001732518,0.0002704763,0.0001007166,0.0001526935,0.0001289776,0.0001943491,0.0005175883],"category_scores_gemma":[0.00008767547,0.00005551999,0.0001636364,0.0001715665,0.0001778433,0.0001263333,0.000131211,0.00029899,0.0001225522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113155,"about_ca_system_score_gemma":0.000289949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003823788,"about_ca_topic_score_gemma":0.0005608981,"domain_scores_codex":[0.9999541,0.000007465017,0.000003215257,0.0000082962,0.00001651237,0.00001033777],"domain_scores_gemma":[0.9999577,0.000007645885,0.00001086561,0.000003688184,0.000007100236,0.0000129528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005592025,0.00001698916,0.00007679281,0.00008971962,0.000002388975,0.00005586891,0.000007102975,0.00006746216,0.997068,0.00004520642,0.00001741216,0.002497219],"study_design_scores_gemma":[0.00002948284,0.001204411,0.005921535,0.00001552888,0.00002362136,0.0003255046,0.00001709562,0.0003228671,0.9894289,0.00004733411,0.002655814,0.000007907352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853871,0.00948211,0.001579504,0.0001123311,0.00003050258,0.00006276386,0.0004265551,0.00003392337,0.002885144],"genre_scores_gemma":[0.9949211,0.002354878,0.001545797,0.00005734257,0.00001593392,0.00001638055,0.0002743452,0.000004967413,0.0008094109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005175883,"threshold_uncertainty_score":0.001731455,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4406400543","doi":"10.2174/0115734064310145240822060730","title":"An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive","year":2025,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Nilotinib; Dasatinib; Kinase; Docking (animal); Kinome; Pharmacology; Parkinson's disease; Chemistry; In silico; Tyrosine kinase; Biochemistry; Biology; Medicine; Signal transduction; Disease","authors":[{"name":"Haruna Isiyaku Umar","is_ca":false},{"name":"Zainab Ashimiyu‐Abdusalam","is_ca":false},{"name":"Neeraj Kumar","is_ca":false},{"name":"Najwa Ahmad Kuthi","is_ca":false},{"name":"Omoboyede Victor","is_ca":false},{"name":"Zainab Naeem Abdulsalam","is_ca":false},{"name":"E. O. Aribo","is_ca":false},{"name":"Ridwan Opeyemi Bello","is_ca":false},{"name":"Yousef A. Bin Jardan","is_ca":true},{"name":"Hiba‐Allah Nafidi","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01263559118799483,"gpt":0.2803892550663238,"spread":0.2677536638783289,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005454432,0.001487537,0.00150928,0.001321372,0.0005795943,0.001152329,0.001364126,0.001359923,0.004795654],"category_scores_gemma":[0.001193349,0.0005891212,0.001783163,0.0009172541,0.0002834677,0.000484347,0.0007430019,0.0008775995,0.0005667536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007430905,"about_ca_system_score_gemma":0.001996728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009862406,"about_ca_topic_score_gemma":0.01418078,"domain_scores_codex":[0.9998507,0.00004444907,0.00001020794,0.00002574444,0.0000379596,0.00003083764],"domain_scores_gemma":[0.9996845,0.0001959685,0.00002490764,0.00001366228,0.00005165641,0.00002938508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002910176,0.000279346,0.002764917,0.0004236218,0.0003811044,0.0003147965,0.00005264105,0.968631,0.002255949,0.004107957,0.002597085,0.01790066],"study_design_scores_gemma":[0.00005048976,0.00006251622,0.0002113894,0.00001376576,0.00007174276,0.00002746864,0.00002462172,0.9966912,0.0003419863,0.001282191,0.001217036,0.000005485106],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5673674,0.007739284,0.3600677,0.002537207,0.0004392802,0.0008952381,0.01020843,0.007017445,0.04372811],"genre_scores_gemma":[0.7640687,0.002091937,0.2184618,0.0005756511,0.00008895835,0.001135149,0.008130327,0.000381512,0.005065901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009862406,"threshold_uncertainty_score":0.01960999,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2318920969","doi":"10.2174/157340611794859352","title":"Chemical Synthesis, Characterisation and Biological Evaluation of Furanic- Estradiol Derivatives as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1","year":2011,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Wilfrid Laurier University; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Hydroxysteroid dehydrogenase; Dehydrogenase; Combinatorial chemistry; Chemistry; 11β-hydroxysteroid dehydrogenase type 1; Enzyme; Biochemistry","authors":[{"name":"Siham Farhane","is_ca":true},{"name":"Yannick Laplante","is_ca":false},{"name":"Donald Poirier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1133063493926297,"gpt":0.3041589448177555,"spread":0.1908525954251258,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621067,0.0003023294,0.0002464938,0.000172364,0.0001244907,0.0001313354,0.0002382012,0.000215089,0.001120093],"category_scores_gemma":[0.0001545176,0.0001157579,0.0002170248,0.0002230896,0.0001218115,0.0001180887,0.0001142216,0.0002473859,0.0004524403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957115,"about_ca_system_score_gemma":0.0001715711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009163914,"about_ca_topic_score_gemma":0.001275951,"domain_scores_codex":[0.9999057,0.0000198179,0.0000076981,0.00001725912,0.00002406846,0.00002540052],"domain_scores_gemma":[0.9999204,0.00001526296,0.00001444781,0.000009524409,0.00002722011,0.00001322273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001287334,0.00006705929,0.000135471,0.0001029613,0.00001063376,0.0001124378,0.00002912527,0.000553673,0.9939876,0.0001544074,0.00006083161,0.004657184],"study_design_scores_gemma":[0.00002003233,0.0006956906,0.0008302958,0.000009605269,0.00001767284,0.0001198003,0.0000163992,0.0002673001,0.9919304,0.000025309,0.006058898,0.000008589923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806648,0.007608349,0.005406384,0.00009519124,0.00003828417,0.000197809,0.0008403988,0.00004687379,0.005101986],"genre_scores_gemma":[0.9781885,0.005875742,0.007095054,0.00006294697,0.00001632741,0.000105385,0.001300053,0.00002322191,0.007332744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120093,"threshold_uncertainty_score":0.003747106,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4392365481","doi":"10.2174/0115734064271581231219111952","title":"Biochemical and In Silico Studies on Triazole Derivatives as TyrosinaseInhibitors: Potential Treatment of Hyperpigmentation Related SkinDisorders","year":2024,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"Higher Education Commission, Pakistan","keywords":"Tyrosinase; Kojic acid; Chemistry; Hyperpigmentation; Melanin; Enzyme; Docking (animal); IC50; Stereochemistry; Biochemistry; Active site; Melasma; In vitro; Biology","authors":[{"name":"Yusra Choudhary","is_ca":false},{"name":"Atia‐tul Wahab","is_ca":false},{"name":"Humaira Zafar","is_ca":false},{"name":"Salman Siddiqui","is_ca":false},{"name":"Majid Khan","is_ca":false},{"name":"Khalid Mohammed Khan","is_ca":false},{"name":"Amer H. Asseri","is_ca":true},{"name":"M. Iqbal Choudhary","is_ca":false},{"name":"Atta‐ur Rahman","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01182934870182438,"gpt":0.304447585426982,"spread":0.2926182367251576,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005302638,0.001043967,0.001576383,0.000708581,0.0003246218,0.0008487793,0.0006551904,0.0006068939,0.004093581],"category_scores_gemma":[0.0007691057,0.0003139832,0.00218502,0.0007538476,0.0001792157,0.0003351868,0.0002796209,0.0005529465,0.000638658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005919238,"about_ca_system_score_gemma":0.0008046068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004381084,"about_ca_topic_score_gemma":0.007351402,"domain_scores_codex":[0.9997817,0.00005175127,0.00001465721,0.00005234862,0.00005862359,0.00004095749],"domain_scores_gemma":[0.9997203,0.0001332132,0.00006294221,0.00001035704,0.00004945222,0.00002374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00341769,0.002666748,0.02975854,0.007811242,0.001841135,0.002470197,0.0001379465,0.6842989,0.2026616,0.002661035,0.004756403,0.05751846],"study_design_scores_gemma":[0.0004582182,0.00840594,0.0166161,0.0003197337,0.002682413,0.001475047,0.0002350909,0.8498011,0.09873238,0.00131405,0.01979825,0.0001617133],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438491,0.02837543,0.01178107,0.0006459425,0.0001243934,0.0002601141,0.006255976,0.000526588,0.008181348],"genre_scores_gemma":[0.9685643,0.009571198,0.01367659,0.0001447565,0.0000281782,0.0001399217,0.00520917,0.00005363109,0.00261226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004381084,"threshold_uncertainty_score":0.01369441,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4220877871","doi":"10.2174/1573406418666220322154110","title":"1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)-4-Piperidone Hydrochloride and Related Compounds: PotentCytotoxins Demonstrate Greater Toxicity to Neoplasms than Non-Malignant Cells","year":2022,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"Mitacs","keywords":"Cytotoxicity; Toxicity; Chemistry; Potency; Apoptosis; Pharmacology; Doxorubicin; Chemotherapy; Stereochemistry; Cancer research; Toxicology; In vitro; Medicine; Biology; Biochemistry; Internal medicine; Organic chemistry","authors":[{"name":"Praveen K. Roayapalley","is_ca":true},{"name":"Jonathan R. Dimmock","is_ca":true},{"name":"Hiroshi Sakagami","is_ca":false},{"name":"Noriyki Okudaira","is_ca":false},{"name":"Rajendra K. Sharma","is_ca":true},{"name":"Umashankar Das","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01148454478787289,"gpt":0.2159848677169511,"spread":0.2045003229290782,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330591,0.0002844271,0.0001954496,0.0001217838,0.00008087388,0.0001002374,0.0001591603,0.0001641543,0.001409242],"category_scores_gemma":[0.0001241283,0.00009019313,0.0001692582,0.0001338126,0.0001374444,0.0001577708,0.0001119637,0.0003737488,0.0004185945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115672,"about_ca_system_score_gemma":0.0001807513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002816345,"about_ca_topic_score_gemma":0.0006803611,"domain_scores_codex":[0.9999076,0.0000217326,0.000007990144,0.00001727803,0.00003050392,0.00001485391],"domain_scores_gemma":[0.9999107,0.00001857157,0.00004366878,0.000007930257,0.00001023622,0.000008917792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001637926,0.00009881713,0.0003330762,0.0002359937,0.0000106513,0.00006823941,0.00001078693,0.0007706466,0.9899637,0.0001590921,0.00009241283,0.008092819],"study_design_scores_gemma":[0.0000891517,0.004695004,0.006649379,0.00003185782,0.00004147676,0.0005836572,0.00002155807,0.002524042,0.9772221,0.0000806843,0.008046316,0.0000147371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725918,0.0128019,0.009110854,0.000177743,0.00005500957,0.00008655261,0.0003892496,0.0001002818,0.00468676],"genre_scores_gemma":[0.9855752,0.005413717,0.006015,0.00007088952,0.00002055101,0.00005364328,0.0004209925,0.000009092908,0.002420917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409242,"threshold_uncertainty_score":0.00471437,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}