{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":67,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":67,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"4b4c0caea937","filters":{"venue":"Metabolic Engineering"}},"results":[{"id":"W2016652826","doi":"10.1016/j.ymben.2013.05.004","title":"Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production","year":2013,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":417,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Lawrence Berkeley National Laboratory; Biological and Environmental Research; Directorate for Biological Sciences; Petroleum Technology Research Centre; Gyeongsang National University","keywords":"Metabolic engineering; Escherichia coli; Alcohol; Limonene; Production (economics); Chemistry; Biochemistry; Biotechnology; Food science; Biology; Enzyme; Economics","authors":[{"name":"Jorge Alonso-Gutiérrez","is_ca":false},{"name":"Rossana Chan","is_ca":false},{"name":"Tanveer S. Batth","is_ca":false},{"name":"Paul D. Adams","is_ca":false},{"name":"Jay D. Keasling","is_ca":false},{"name":"Christopher J. Petzold","is_ca":false},{"name":"Taek Soon Lee","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006656740572559443,"gpt":0.2011067605871071,"spread":0.1944500200145477,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736883,0.0004113729,0.0002166599,0.0003220992,0.0001931352,0.0004739128,0.0002816925,0.0002566646,0.0004471049],"category_scores_gemma":[0.0001978615,0.0001652874,0.0002835249,0.0004007522,0.0001469511,0.0001731636,0.0003071132,0.0004425014,0.0003276527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004321109,"about_ca_system_score_gemma":0.0004813573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002335191,"about_ca_topic_score_gemma":0.003266104,"domain_scores_codex":[0.9998171,0.00003439159,0.00001842289,0.00001914622,0.00006751332,0.00004348458],"domain_scores_gemma":[0.9999386,0.00001232039,0.00001075683,0.000006870742,0.00001747877,0.00001389384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001232294,0.0000936007,0.0004160128,0.00004288529,0.000008374017,0.00009799367,0.00002043389,0.0006243562,0.9939942,0.0003822251,0.00004378316,0.00415289],"study_design_scores_gemma":[0.000006585804,0.0000755916,0.000700697,0.000002955734,0.00001241821,0.00008738034,0.00003067119,0.001126175,0.9961835,0.00004519975,0.001723388,0.000005453095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98348,0.0004501846,0.01289517,0.0002806128,0.00004553021,0.00006391147,0.0003957175,0.0001058484,0.002283156],"genre_scores_gemma":[0.9838638,0.0006426962,0.010859,0.0000629967,0.000004927784,0.00002857295,0.0005720147,0.00004178367,0.003924155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002335191,"threshold_uncertainty_score":0.004643202,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2004174459","doi":"10.1016/j.ymben.2010.02.002","title":"Chlamydomonas starchless mutant defective in ADP-glucose pyrophosphorylase hyper-accumulates triacylglycerol","year":2010,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Algal biology and biofuel production","field":"Energy","cited_by":384,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Arizona State University; University of Alberta; Science Foundation Arizona","keywords":"Chlamydomonas; Biochemistry; Metabolic engineering; Biofuel; Mutant; Photosynthesis; Chloroplast; Metabolic pathway; Starch; Biology; Chemistry; Enzyme; Biotechnology; Gene","authors":[{"name":"Yantao Li","is_ca":false},{"name":"Danxiang Han","is_ca":false},{"name":"Guongrong Hu","is_ca":false},{"name":"David Dauvillée","is_ca":false},{"name":"Milton R. Sommerfeld","is_ca":false},{"name":"Steven Ball","is_ca":false},{"name":"Qiang Hu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008212334867225562,"gpt":0.2216781852698206,"spread":0.2134658504025951,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000205458,0.00101999,0.0004137659,0.0004126427,0.0003076407,0.0006721799,0.0006878714,0.0005151751,0.001207054],"category_scores_gemma":[0.0002094325,0.0005315413,0.0004601587,0.0005498656,0.0005866586,0.000376549,0.0007653445,0.001150297,0.0005926718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008385078,"about_ca_system_score_gemma":0.0006918002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004183698,"about_ca_topic_score_gemma":0.004346561,"domain_scores_codex":[0.9997504,0.00001859344,0.00003331117,0.00004566212,0.00009539792,0.00005657236],"domain_scores_gemma":[0.9996221,0.00007181395,0.00007871124,0.00008500875,0.00002830766,0.0001139483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006115188,0.00001449328,0.000070799,0.000009515584,0.000003556324,0.00005389511,0.000007679133,0.00002240091,0.9994418,0.00005769268,0.0000153871,0.0002415704],"study_design_scores_gemma":[0.00002389067,0.0000794113,0.003413005,0.000004317219,0.00002775902,0.0003589752,0.00006063146,0.0005822405,0.9944503,0.00007627477,0.0009103183,0.00001275624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942837,0.0002570546,0.003509071,0.0001561077,0.00009253946,0.00002208833,0.0006089459,0.0001709023,0.0008995389],"genre_scores_gemma":[0.9944395,0.0002158673,0.001557956,0.00005374609,0.00000839257,0.00002145861,0.0008186984,0.00008795803,0.002796469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004183698,"threshold_uncertainty_score":0.008318722,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2050461585","doi":"10.1016/j.ymben.2011.02.002","title":"Optimization of a heterologous pathway for the production of flavonoids from glucose","year":2011,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":314,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of General Medical Sciences; Petroleum Technology Research Centre; National Science Foundation","keywords":"Naringenin; Chalcone synthase; Biochemistry; Metabolic engineering; Cerulenin; Enzyme; Fermentation; Flavonoid; Chemistry; Biology; Biosynthesis; Fatty acid synthase","authors":[{"name":"Christine Nicole S. Santos","is_ca":false},{"name":"Mattheos Koffas","is_ca":false},{"name":"Gregory Stephanopoulos","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09539392719690196,"gpt":0.3517481274572256,"spread":0.2563542002603236,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002308888,0.0006631934,0.0006101706,0.0002936725,0.0002186716,0.000836576,0.0004930717,0.0004083996,0.0007682633],"category_scores_gemma":[0.000259664,0.0001604314,0.0005266116,0.0006793176,0.0002300518,0.0004086148,0.0003995498,0.00105315,0.0005108592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006416677,"about_ca_system_score_gemma":0.0004895261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002003214,"about_ca_topic_score_gemma":0.002029511,"domain_scores_codex":[0.9997893,0.0000396343,0.00002587918,0.00004065763,0.00006191265,0.0000427204],"domain_scores_gemma":[0.9999033,0.00002245378,0.00002420527,0.0000145583,0.00001454303,0.00002087411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001270723,0.00009637266,0.0001707185,0.00005081384,0.00001214973,0.00007815265,0.00001961972,0.000691177,0.9953082,0.0003115125,0.00005156587,0.003082647],"study_design_scores_gemma":[0.00001607142,0.000138447,0.0008582062,0.000008502187,0.00002404983,0.0001154799,0.00003699237,0.002336157,0.9938658,0.00008762581,0.00250147,0.00001118205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620909,0.0006908837,0.03230037,0.0003490264,0.00008373151,0.0001370127,0.001279506,0.0002599888,0.002808561],"genre_scores_gemma":[0.9613904,0.0008114729,0.03132829,0.00004955301,0.00001032841,0.00008842133,0.002849752,0.0001453529,0.00332642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002003214,"threshold_uncertainty_score":0.004655719,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2030168212","doi":"10.1016/j.ymben.2012.01.007","title":"Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene α-santalene in a fed-batch mode","year":2012,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":251,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Fondation Chalmers; Knut och Alice Wallenbergs Stiftelse","keywords":"Saccharomyces cerevisiae; Metabolic engineering; Biochemistry; Farnesyl diphosphate synthase; Reductase; Biology; Farnesyl pyrophosphate; Squalene; Yeast; Gene; Enzyme; Phosphatase; ATP synthase; Chemistry","authors":[{"name":"Gionata Scalcinati","is_ca":false},{"name":"Christoph Knuf","is_ca":false},{"name":"Siavash Partow","is_ca":false},{"name":"Yun Chen","is_ca":false},{"name":"Jérôme Maury","is_ca":false},{"name":"Michel Schalk","is_ca":false},{"name":"Laurent Daviet","is_ca":false},{"name":"Jens Nielsen","is_ca":false},{"name":"Verena Siewers","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005863180046202295,"gpt":0.2138500094984815,"spread":0.2079868294522792,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158167,0.0003150645,0.0002061133,0.0001627785,0.0001154251,0.0006786531,0.0002466607,0.000147822,0.0004244225],"category_scores_gemma":[0.0001765307,0.0001656163,0.0001889994,0.0002073969,0.0002982685,0.0002089729,0.0001811184,0.0003748108,0.0001585181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006327656,"about_ca_system_score_gemma":0.000204268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002279098,"about_ca_topic_score_gemma":0.002484194,"domain_scores_codex":[0.9999141,0.000009820687,0.00001061747,0.00002674376,0.00002706394,0.00001176193],"domain_scores_gemma":[0.9998759,0.00003406951,0.00002770302,0.00001872165,0.00002147999,0.00002221415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001368147,0.00002252201,0.0001806068,0.00001320079,0.00000407587,0.00001699433,0.00002013502,0.0003151431,0.9982412,0.0001665905,0.00001883789,0.0008639294],"study_design_scores_gemma":[0.00001603679,0.0000545914,0.001109708,0.000002519891,0.000009184552,0.00002476192,0.00002199915,0.005548522,0.9925073,0.00006367426,0.0006336393,0.000007945764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955242,0.0002779567,0.003002671,0.00007507332,0.0000306449,0.00001183524,0.0002778827,0.0001304185,0.0006694365],"genre_scores_gemma":[0.9968761,0.0001742741,0.001636147,0.0000161393,0.000003517624,0.0000105084,0.0001848804,0.00003177607,0.001066516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279098,"threshold_uncertainty_score":0.004591048,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2884144545","doi":"10.1016/j.ymben.2018.07.016","title":"Metabolic engineering in the host Yarrowia lipolytica","year":2018,"lang":"en","type":"review","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":235,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Office of Naval Research; Natural Sciences and Engineering Research Council of Canada; Welch Foundation; U.S. Department of Energy","keywords":"Yarrowia; Metabolic engineering; Organism; Yeast; Biology; Metabolic pathway; Synthetic biology; Host (biology); Flux (metallurgy); Model organism; Metabolic flux analysis; Industrial microbiology; Saccharomyces cerevisiae; Computational biology; Biochemistry; Metabolism; Chemistry; Gene; Genetics","authors":[{"name":"Ahmad Mohammad Abdel‐Mawgoud","is_ca":false},{"name":"Kelly A. Markham","is_ca":false},{"name":"Claire M. Palmer","is_ca":false},{"name":"Nian Liu","is_ca":false},{"name":"Gregory Stephanopoulos","is_ca":false},{"name":"Hal S. Alper","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01406582813416732,"gpt":0.2529592936478142,"spread":0.2388934655136468,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004051611,0.000995522,0.001252034,0.001605909,0.0001852305,0.001203763,0.0007089376,0.0007543155,0.001253103],"category_scores_gemma":[0.0003706586,0.0003235969,0.0004264607,0.002428157,0.0003219113,0.001225614,0.0007079699,0.001166777,0.0009863301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004713446,"about_ca_system_score_gemma":0.0006011683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005745616,"about_ca_topic_score_gemma":0.0009227009,"domain_scores_codex":[0.9998379,0.00001695566,0.00002082278,0.00003832388,0.00006477212,0.00002120023],"domain_scores_gemma":[0.999872,0.00004487698,0.00003656223,0.000007408972,0.00002619711,0.00001295423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001204508,0.00009608822,0.0002192605,0.02220699,0.0001219977,0.0003430854,0.00004789002,0.0009274018,0.037032,0.005536294,0.006949339,0.9263992],"study_design_scores_gemma":[0.00002037924,0.0001541349,0.001128237,0.002453092,0.0002183374,0.001318037,0.00005535595,0.0004188731,0.01812932,0.002525924,0.9735401,0.00003809413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000841184,0.996852,0.0007104967,0.0001338223,0.0001074507,0.000005541808,0.00003263155,0.00001434787,0.001302508],"genre_scores_gemma":[0.003205695,0.9949865,0.0006538227,0.00009449377,0.00004879087,0.00000661596,0.00006528883,0.000004464861,0.0009343284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001605909,"threshold_uncertainty_score":0.004192054,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2022828569","doi":"10.1016/j.ymben.2014.11.011","title":"Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering","year":2014,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Biological and Environmental Research; Lawrence Berkeley National Laboratory; Directorate for Biological Sciences; U.S. Department of Energy; Petroleum Technology Research Centre; Fundación Ramón Areces; University of California Berkeley","keywords":"Proteomics; Heterologous; Computational biology; Metabolic engineering; Biology; Enzyme; Biochemistry; Gene","authors":[{"name":"Jorge Alonso-Gutiérrez","is_ca":false},{"name":"Eun‐Mi Kim","is_ca":false},{"name":"Tanveer S. Batth","is_ca":false},{"name":"Nathan Cho","is_ca":false},{"name":"Qijun Hu","is_ca":false},{"name":"Leanne Jade G. Chan","is_ca":false},{"name":"Christopher J. Petzold","is_ca":false},{"name":"Nathan J. Hillson","is_ca":false},{"name":"Paul D. Adams","is_ca":false},{"name":"Jay D. Keasling","is_ca":false},{"name":"Héctor García Martín","is_ca":false},{"name":"Taek Soon Lee","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004464810435472395,"gpt":0.1988515784851687,"spread":0.1943867680496963,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001287418,0.001220041,0.0008343367,0.001682418,0.0005676749,0.001152793,0.0004067954,0.0002895962,0.001784234],"category_scores_gemma":[0.002493719,0.0004800864,0.001006797,0.002621038,0.000506508,0.0006138257,0.000817063,0.001597083,0.0008668417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003400884,"about_ca_system_score_gemma":0.001100725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001810814,"about_ca_topic_score_gemma":0.001727878,"domain_scores_codex":[0.9991744,0.0002670328,0.00004403729,0.0001810519,0.0002868556,0.00004657728],"domain_scores_gemma":[0.9991723,0.0004120151,0.00009404014,0.000115586,0.0001616213,0.00004440756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006287774,0.0003395598,0.004105461,0.0008322582,0.0004001331,0.000163217,0.0001754513,0.01595064,0.5162905,0.02395085,0.005815004,0.4313482],"study_design_scores_gemma":[0.0001165817,0.0006661809,0.02498337,0.00007680814,0.0003476981,0.0008236661,0.0001350691,0.4849342,0.3858831,0.07033306,0.03144313,0.0002571464],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02761747,0.0006894173,0.9655672,0.0002929861,0.00009310027,0.0001026697,0.0008909291,0.003174117,0.001572191],"genre_scores_gemma":[0.2291031,0.001568021,0.7649673,0.0001510578,0.0000835591,0.0003577485,0.001471087,0.0006662113,0.001631945],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001810814,"threshold_uncertainty_score":0.006808579,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2012010696","doi":"10.1016/j.ymben.2013.01.001","title":"Engineering cyanobacteria for photosynthetic production of 3-hydroxybutyrate directly from CO2","year":2013,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Key Research and Development Program of China; Petroleum Technology Alliance Canada","keywords":"Synechocystis; Polyhydroxyalkanoates; Photosynthesis; Cyanobacteria; Metabolic engineering; Biochemistry; Biosynthesis; Chemistry; Biology; Bacteria; Gene","authors":[{"name":"Bo Wang","is_ca":false},{"name":"Shawn Pugh","is_ca":false},{"name":"David R. Nielsen","is_ca":false},{"name":"Weiwen Zhang","is_ca":false},{"name":"Deirdre R. Meldrum","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004225252505541085,"gpt":0.183029461465362,"spread":0.1788042089598209,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002775611,0.0007397999,0.0003984761,0.0003027251,0.000304846,0.0006434556,0.0003568474,0.0003703419,0.0003989732],"category_scores_gemma":[0.0002821683,0.0002312534,0.0004473807,0.0005480943,0.0002954105,0.0004960473,0.0006044584,0.0007858527,0.0003504396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001168544,"about_ca_system_score_gemma":0.001112579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003051461,"about_ca_topic_score_gemma":0.005486217,"domain_scores_codex":[0.9997384,0.00002327721,0.00001948816,0.00002984552,0.0001317733,0.00005709651],"domain_scores_gemma":[0.9999115,0.00001479956,0.00001651807,0.000009282087,0.00002022052,0.00002750713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000367478,0.00002669846,0.0001405883,0.00004347866,0.000006412118,0.00005226403,0.00001665804,0.0002440785,0.997032,0.0003845189,0.00003600213,0.001980552],"study_design_scores_gemma":[0.000006517954,0.00003463233,0.0003175816,0.000004486826,0.000009020211,0.00004978677,0.00001495873,0.0007571802,0.99768,0.00009157285,0.001029498,0.000004770529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960897,0.001831548,0.03106267,0.000637594,0.0001821185,0.0001406298,0.0005034963,0.0001988601,0.004546028],"genre_scores_gemma":[0.9738886,0.001963141,0.02040164,0.00009787636,0.00001365324,0.00005604744,0.0004448887,0.00008301614,0.003051129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003051461,"threshold_uncertainty_score":0.008478463,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2027791436","doi":"10.1016/j.ymben.2014.01.005","title":"Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae","year":2014,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Fondation Chalmers; VINNOVA","keywords":"Saccharomyces cerevisiae; Biochemistry; Chemistry; Production (economics); Yeast; Economics; Microeconomics","authors":[{"name":"Yun Chen","is_ca":false},{"name":"Jichen Bao","is_ca":false},{"name":"Il‐Kwon Kim","is_ca":false},{"name":"Verena Siewers","is_ca":false},{"name":"Jens Nielsen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004194605219919868,"gpt":0.2047388812004928,"spread":0.2005442759805729,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555651,0.0006454118,0.0004432871,0.0002617307,0.0001699372,0.0009752203,0.0005584411,0.0003283694,0.001067254],"category_scores_gemma":[0.0003102048,0.0002392896,0.0003214834,0.0004963888,0.0002239201,0.0004120721,0.0005497126,0.0006318417,0.0002569582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005540678,"about_ca_system_score_gemma":0.0004459828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003132728,"about_ca_topic_score_gemma":0.004089056,"domain_scores_codex":[0.9998198,0.00002299881,0.00002958414,0.0000435826,0.00005500505,0.00002916739],"domain_scores_gemma":[0.9998684,0.00003155853,0.00002666489,0.00001690399,0.00002236825,0.00003403788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004489337,0.000141367,0.0003121697,0.00006398037,0.00001785226,0.00004970642,0.00001829736,0.0005803269,0.9939792,0.00007334371,0.00004018406,0.004274586],"study_design_scores_gemma":[0.00002607739,0.0002419538,0.0009160417,0.000006913168,0.00003505698,0.00003558263,0.00002332182,0.00244617,0.9957343,0.00003519761,0.0004915843,0.000007903177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968251,0.0005014203,0.001560388,0.00006581037,0.00002816913,0.0000163715,0.0001657296,0.0001061713,0.0007308683],"genre_scores_gemma":[0.9967977,0.0003496441,0.001829804,0.00002477534,0.000006142728,0.00001106458,0.0002261517,0.00003251614,0.0007221287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003132728,"threshold_uncertainty_score":0.006228983,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3046548390","doi":"10.1016/j.ymben.2020.07.010","title":"Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity","year":2020,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"Singapore-MIT Alliance for Research and Technology Centre; U.S. Department of Energy","keywords":"Yarrowia; Terpenoid; Biochemistry; Yeast; Lycopene; Mevalonate pathway; Metabolic engineering; Chemistry; Intracellular; Isopentenyl pyrophosphate; Carotenoid; Biosynthesis; Biology; Enzyme","authors":[{"name":"Zhengshan Luo","is_ca":false},{"name":"Nian Liu","is_ca":false},{"name":"Zbigniew Lazar","is_ca":false},{"name":"Alkiviadis Orfefs Chatzivasileiou","is_ca":false},{"name":"Valerie C. A. Ward","is_ca":true},{"name":"Jian Chen","is_ca":false},{"name":"Jingwen Zhou","is_ca":false},{"name":"Gregory Stephanopoulos","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0109172514439151,"gpt":0.1904814635480617,"spread":0.1795642121041466,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882661,0.0004430712,0.0003427615,0.0001945727,0.0001978008,0.0004640361,0.0002469667,0.000297426,0.0005372539],"category_scores_gemma":[0.0001494618,0.0001891919,0.0002589256,0.0002265631,0.0002320412,0.0002642739,0.0003911065,0.0008430415,0.0003629753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004656152,"about_ca_system_score_gemma":0.0002474942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007376623,"about_ca_topic_score_gemma":0.000934548,"domain_scores_codex":[0.9998778,0.00001948168,0.00001757239,0.00002459699,0.00003034117,0.00003018717],"domain_scores_gemma":[0.9998298,0.00003797684,0.00005276466,0.00002830382,0.00001648883,0.00003472907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003576985,0.000009645962,0.00004566698,0.000006305467,0.000001182591,0.000009800368,0.00000503772,0.00002750508,0.9996606,0.0000378094,0.000003278357,0.0001574468],"study_design_scores_gemma":[0.00001507151,0.00008717339,0.001822528,0.000003164688,0.00001259605,0.00004282128,0.00002608514,0.0009537226,0.9964055,0.00003994329,0.0005854655,0.000005996721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956948,0.0003367787,0.002980178,0.0001077654,0.00002181149,0.00001586589,0.000227574,0.00007535784,0.0005397815],"genre_scores_gemma":[0.9944751,0.0002731833,0.002735514,0.00003839538,0.00000825604,0.00003217736,0.0004471588,0.00004630378,0.001943825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007376623,"threshold_uncertainty_score":0.003378272,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2127869220","doi":"10.1016/j.ymben.2008.06.004","title":"Dynamic metabolic engineering for increasing bioprocess productivity","year":2008,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Bioprocess; Metabolic engineering; Biochemical engineering; Productivity; Metabolic network; Biotechnology; Bioprocess engineering; Fermentation; Biology; Computational biology; Engineering; Biochemistry; Gene","authors":[{"name":"Nikolaos Anesiadis","is_ca":true},{"name":"W.R. Cluett","is_ca":true},{"name":"Radhakrishnan Mahadevan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006496715044703758,"gpt":0.2088065459364268,"spread":0.202309830891723,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799458,0.000707758,0.0005498886,0.0003469786,0.0002513744,0.001103377,0.0005800447,0.0003773711,0.001372746],"category_scores_gemma":[0.0003023461,0.000360626,0.0003793122,0.0005705215,0.0003262541,0.001241814,0.0008626024,0.0009064129,0.0004002368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006835766,"about_ca_system_score_gemma":0.0002637722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003979277,"about_ca_topic_score_gemma":0.0007651052,"domain_scores_codex":[0.9998407,0.00001767302,0.00001128821,0.00003899219,0.00006082805,0.00003050659],"domain_scores_gemma":[0.999911,0.00002421841,0.00001981371,0.00001567486,0.00001315988,0.00001629905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001575386,0.0001223572,0.0001630222,0.0001144115,0.00001675951,0.00004621294,0.00001769543,0.003010812,0.9763782,0.002858065,0.0002185772,0.01689629],"study_design_scores_gemma":[0.00005263398,0.0001988537,0.0004369784,0.00001393924,0.00004097715,0.000187162,0.00003037159,0.0275182,0.9609126,0.002237031,0.008348731,0.00002247758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7352517,0.005756254,0.2444653,0.001005073,0.0002928621,0.0001290786,0.00062967,0.001276279,0.01119383],"genre_scores_gemma":[0.9656237,0.002573227,0.02838421,0.0001191784,0.00005266643,0.0001062417,0.0004084003,0.0001408066,0.002591494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372746,"threshold_uncertainty_score":0.004959702,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2050257753","doi":"10.1016/j.ymben.2006.02.003","title":"Metabolic engineering of malolactic wine yeast","year":2006,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Malolactic fermentation; Yeast; Metabolic engineering; Wine; Yeast in winemaking; Biology; Food science; Computational biology; Saccharomyces cerevisiae; Biochemistry; Genetics; Enzyme; Bacteria; Lactic acid","authors":[{"name":"John I. Husnik","is_ca":true},{"name":"Heinrich Volschenk","is_ca":false},{"name":"Jürgen Bauer","is_ca":false},{"name":"Didier Colavizza","is_ca":false},{"name":"Zongli Luo","is_ca":true},{"name":"Hennie J.J. van Vuuren","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003374987868976817,"gpt":0.1928897260106421,"spread":0.1895147381416653,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339349,0.0005167153,0.0003155672,0.0003975383,0.0002196866,0.0005588213,0.0003146068,0.0002084927,0.0003752711],"category_scores_gemma":[0.0001351522,0.0001948155,0.0003208401,0.0004319439,0.0001488433,0.0002060361,0.000476221,0.000593086,0.0002043118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00037369,"about_ca_system_score_gemma":0.0002627809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266284,"about_ca_topic_score_gemma":0.001792648,"domain_scores_codex":[0.9998841,0.00001963417,0.00001713009,0.0000169524,0.00004176413,0.00002040141],"domain_scores_gemma":[0.9999378,0.000008239068,0.00001264143,0.000007497608,0.00001369061,0.00002016645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008986335,0.00003537151,0.0001853456,0.00005539706,0.000006707172,0.000107251,0.00003445052,0.0004381384,0.9937136,0.0005182328,0.00002664284,0.004788975],"study_design_scores_gemma":[0.000008408388,0.00009690349,0.0006335397,0.000007478048,0.00001791432,0.0001472108,0.00004070572,0.001425894,0.9940142,0.0001290996,0.003472858,0.000005769832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719223,0.001344895,0.02305435,0.0002551975,0.00007731772,0.00006719261,0.0003817281,0.0001952051,0.002701808],"genre_scores_gemma":[0.9813374,0.001867498,0.01182916,0.00004229918,0.00001223147,0.00003232972,0.0005615054,0.00007584979,0.004241777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266284,"threshold_uncertainty_score":0.002711356,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2091340251","doi":"10.1016/j.ymben.2015.03.009","title":"Autonomous production of 1,4-butanediol via a de novo biosynthesis pathway in engineered Escherichia coli","year":2015,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"University of Illinois at Urbana-Champaign; Petroleum Technology Research Centre","keywords":"Synthetic biology; Metabolic engineering; 2,3-Butanediol; Biosynthesis; Quorum sensing; Xylose; Escherichia coli; Biochemical engineering; Modular design; Production (economics); Computational biology; Carbon source; Biology; Biochemistry; Computer science; Enzyme; Fermentation; Gene; Engineering; Virulence","authors":[{"name":"Huaiwei Liu","is_ca":false},{"name":"Ting Lu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007958024396752486,"gpt":0.1969739159599288,"spread":0.1890158915631763,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757278,0.0005643888,0.0003565759,0.0002375413,0.0001805282,0.0007361984,0.0002689666,0.0002786363,0.0002434605],"category_scores_gemma":[0.0002351311,0.0001882684,0.0002071911,0.0002429466,0.0002338507,0.0002828686,0.0003632149,0.0005343258,0.0002760857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005162199,"about_ca_system_score_gemma":0.0004942406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002059373,"about_ca_topic_score_gemma":0.002654669,"domain_scores_codex":[0.9998253,0.00002643546,0.00002153014,0.00003197236,0.00005790341,0.00003679126],"domain_scores_gemma":[0.9998302,0.00004457271,0.00002905709,0.0000290705,0.00002864747,0.0000384372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000681067,0.00004096372,0.0002153579,0.00002013355,0.000003555229,0.00005114336,0.00001049277,0.0002840435,0.9979143,0.0001583868,0.00001343932,0.001220021],"study_design_scores_gemma":[0.000008604718,0.00004924266,0.0004224634,0.000002329445,0.000006960323,0.00004692149,0.00001429388,0.001226795,0.9977011,0.00003967025,0.0004768509,0.000004750119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920418,0.0002834279,0.006006444,0.0001425441,0.0000462413,0.00003012527,0.0002216562,0.00009411326,0.001133673],"genre_scores_gemma":[0.9895186,0.0003986215,0.00671291,0.00003783722,0.000006127432,0.00001876549,0.000332519,0.00004751761,0.002927136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059373,"threshold_uncertainty_score":0.004094839,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2147598079","doi":"10.1016/j.ymben.2011.03.002","title":"EMILiO: A fast algorithm for genome-scale strain design","year":2011,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada","keywords":"Scalability; Scope (computer science); Computational complexity theory; Computer science; Computational model; Scale (ratio); Flux balance analysis; Strain (injury); Biochemical engineering; Algorithm; Distributed computing; Mathematical optimization; Mathematics; Engineering; Computational biology; Biology","authors":[{"name":"Laurence Yang","is_ca":true},{"name":"W.R. Cluett","is_ca":true},{"name":"Radhakrishnan Mahadevan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01450824573368644,"gpt":0.2010562036756021,"spread":0.1865479579419157,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001631871,0.003936899,0.001953254,0.001779141,0.001122992,0.001927265,0.003405652,0.002429243,0.01460236],"category_scores_gemma":[0.005891845,0.001399526,0.002101701,0.001485081,0.0007451639,0.001909067,0.002530278,0.002741884,0.004784861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001314649,"about_ca_system_score_gemma":0.001825182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003259156,"about_ca_topic_score_gemma":0.005023197,"domain_scores_codex":[0.9991097,0.0002586796,0.00006074295,0.0002166529,0.0002197218,0.000134518],"domain_scores_gemma":[0.9985637,0.000920209,0.00007029511,0.0001644147,0.0002157265,0.0000655929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001250726,0.000339913,0.001477676,0.0007372263,0.0001983013,0.0002245197,0.0001710048,0.1720505,0.0200358,0.01178404,0.02639145,0.7653389],"study_design_scores_gemma":[0.0003356634,0.0001440114,0.0001834542,0.00004648873,0.00005544855,0.00008255115,0.00003896076,0.9611007,0.01199876,0.01360755,0.01236407,0.00004234962],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.004135693,0.0002039849,0.9721056,0.0001035137,0.0000803258,0.0001368989,0.0004037535,0.02134508,0.001485274],"genre_scores_gemma":[0.02791303,0.00009299555,0.967226,0.0001502223,0.00001991447,0.0005035168,0.0009239818,0.002110558,0.001059753],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01460236,"threshold_uncertainty_score":0.04884976,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2801885456","doi":"10.1016/j.ymben.2018.04.016","title":"Metabolic engineering to enhance heterologous production of hyaluronic acid in Bacillus subtilis","year":2018,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"","keywords":"Bacillus subtilis; Hyaluronan synthase; Catabolite repression; Biochemistry; Metabolic engineering; Pentose phosphate pathway; Biology; Heterologous; Biosynthesis; Microbiology; Chemistry; Bacteria; Metabolism; Enzyme; Glycolysis; Gene; Genetics; Mutant","authors":[{"name":"Adam Westbrook","is_ca":true},{"name":"Xiang Ren","is_ca":true},{"name":"Jaewon Oh","is_ca":true},{"name":"Murray Moo‐Young","is_ca":true},{"name":"C. Perry Chou","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006933514246085873,"gpt":0.2576796232775345,"spread":0.2507461090314486,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473064,0.0004018768,0.0002912295,0.0002098621,0.0001761674,0.0004627681,0.0001861805,0.0002041891,0.0004420847],"category_scores_gemma":[0.0001620557,0.0001264737,0.0002802585,0.0004177532,0.0001511189,0.0002129369,0.0003486134,0.00056836,0.0002403345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003371536,"about_ca_system_score_gemma":0.000334585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001657869,"about_ca_topic_score_gemma":0.001856003,"domain_scores_codex":[0.9998653,0.00002453726,0.00001577963,0.00001872284,0.00004443912,0.00003120537],"domain_scores_gemma":[0.9999292,0.00001182339,0.0000205499,0.000007340821,0.00001091511,0.00002018638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001146428,0.00006056733,0.0002002495,0.00004185319,0.000005787144,0.00006842507,0.0000253396,0.000288138,0.9961385,0.0001925873,0.00003128011,0.002832593],"study_design_scores_gemma":[0.00001460113,0.0001291275,0.0009913788,0.00000642623,0.00001662193,0.0001775178,0.00003510361,0.001275362,0.9957476,0.00004415658,0.0015559,0.0000061781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895824,0.0005636346,0.007408572,0.0001758175,0.00003494574,0.00002510989,0.0002206479,0.00009023224,0.001898656],"genre_scores_gemma":[0.9883075,0.0007875781,0.007297231,0.00002888849,0.000008288034,0.00002012699,0.0003929354,0.00004558063,0.003111887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001657869,"threshold_uncertainty_score":0.003296375,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2127455737","doi":"10.1016/j.ymben.2008.06.005","title":"Geobacter sulfurreducens strain engineered for increased rates of respiration","year":2008,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Fuel Cells and Bioremediation","field":"Environmental Science","cited_by":111,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Geobacter sulfurreducens; Geobacter; ATP synthase; Biochemistry; Acetate kinase; Electron transport chain; Respiration; Strain (injury); Citric acid cycle; Chemistry; Phosphate; Biology; ATPase; Metabolism; Biophysics; Enzyme; Gene; Bacteria; Escherichia coli; Biofilm; Genetics","authors":[{"name":"Mounir Izallalen","is_ca":false},{"name":"Radhakrishnan Mahadevan","is_ca":true},{"name":"Anthony P. Burgard","is_ca":false},{"name":"Bradley L. Postier","is_ca":false},{"name":"Raymond J. DiDonato","is_ca":false},{"name":"Jun Sun","is_ca":false},{"name":"Christopher H. Schilling","is_ca":false},{"name":"Derek R. Lovley","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01528034941411984,"gpt":0.2109905340218888,"spread":0.195710184607769,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003288322,0.001032342,0.0006064946,0.0004074937,0.0002197306,0.0005624689,0.0005771093,0.0005437204,0.0006070319],"category_scores_gemma":[0.0002912859,0.0002233848,0.0003370665,0.0005752337,0.0003475752,0.0003550141,0.0005306402,0.0007575893,0.0002840853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005222743,"about_ca_system_score_gemma":0.0005587653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002682401,"about_ca_topic_score_gemma":0.003749752,"domain_scores_codex":[0.9996853,0.00004324652,0.00004100782,0.00005425685,0.0001197005,0.00005657353],"domain_scores_gemma":[0.9998376,0.00002623394,0.00003407285,0.00003117575,0.0000317339,0.00003911538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001142328,0.0001251637,0.0002490438,0.00003276872,0.00001420691,0.00006527518,0.00001769155,0.0001542979,0.9976819,0.000152983,0.0000612605,0.001331259],"study_design_scores_gemma":[0.00004537522,0.0003458923,0.002575832,0.000005164082,0.00003841884,0.0002173396,0.00007759251,0.001155228,0.9937134,0.0001064519,0.001704808,0.00001450334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947015,0.000367921,0.002625532,0.000285586,0.000128103,0.00005105217,0.0006100339,0.0001890155,0.001041393],"genre_scores_gemma":[0.9920155,0.0002878359,0.003889117,0.0000786007,0.00001791578,0.00002490146,0.00120069,0.00006098075,0.002424457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002682401,"threshold_uncertainty_score":0.005333543,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3137032084","doi":"10.1016/j.ymben.2021.02.005","title":"Metabolism of syringyl lignin-derived compounds in Pseudomonas putida enables convergent production of 2-pyrone-4,6-dicarboxylic acid","year":2021,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Biochemical and biochemical processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; U.S. Department of Energy","keywords":"Pseudomonas putida; Lignin; Chemistry; Depolymerization; Biocatalysis; Organic chemistry; Biochemistry; Stereochemistry; Enzyme; Catalysis; Reaction mechanism","authors":[{"name":"Sandra Notonier","is_ca":false},{"name":"Allison Z. Werner","is_ca":false},{"name":"Eugene Kuatsjah","is_ca":true},{"name":"Linda Dumalo","is_ca":true},{"name":"Paul E. Abraham","is_ca":false},{"name":"E. Anne Hatmaker","is_ca":false},{"name":"Caroline B. Hoyt","is_ca":false},{"name":"Antonella Amore","is_ca":false},{"name":"Kelsey J. Ramirez","is_ca":false},{"name":"Sean P. Woodworth","is_ca":false},{"name":"Dawn M. Klingeman","is_ca":false},{"name":"Richard J. Giannone","is_ca":false},{"name":"Adam M. Guss","is_ca":false},{"name":"Robert L. Hettich","is_ca":false},{"name":"Lindsay D. Eltis","is_ca":true},{"name":"Christopher W. Johnson","is_ca":false},{"name":"Gregg T. Beckham","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006502720124494814,"gpt":0.2041616635719477,"spread":0.1976589434474529,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289963,0.0004210915,0.000219846,0.0001591724,0.0001877505,0.0004485347,0.0002279979,0.0002307321,0.0004362209],"category_scores_gemma":[0.0001955531,0.0001447101,0.0001649943,0.0002084345,0.0002137202,0.0002470046,0.0003608146,0.0005958362,0.0002675955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004975608,"about_ca_system_score_gemma":0.0004501954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001825332,"about_ca_topic_score_gemma":0.00375716,"domain_scores_codex":[0.9998651,0.00001783427,0.000009078448,0.00002154246,0.00005639047,0.00003008897],"domain_scores_gemma":[0.9998925,0.00002401724,0.00002023959,0.00001567394,0.00001383185,0.00003369814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005216485,0.00002550177,0.0001288046,0.00001413959,0.000001906088,0.00004527663,0.00001551899,0.0001285393,0.9982358,0.0001493252,0.000009287215,0.001193749],"study_design_scores_gemma":[0.000006530674,0.0001365313,0.001700867,0.000002869095,0.000008729787,0.0001137189,0.00003847111,0.001697487,0.995616,0.00008732023,0.0005849564,0.000006559412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959283,0.0001349061,0.002284826,0.00006343994,0.00001302962,0.00001309578,0.0001050857,0.00005789287,0.00139925],"genre_scores_gemma":[0.9959837,0.0001539287,0.002087063,0.00001247533,0.00000382287,0.000009462036,0.000208243,0.00002229963,0.001519043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825332,"threshold_uncertainty_score":0.003629386,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2087693189","doi":"10.1016/j.ymben.2009.10.007","title":"Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy","year":2009,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Metabolic flux analysis; Glutamine; Biochemistry; Citric acid cycle; Flux (metallurgy); Pentose phosphate pathway; Chemistry; Metabolite; Pyruvate carboxylase; Metabolism; Chromatography; Glycolysis; Amino acid; Enzyme","authors":[{"name":"Chetan T. Goudar","is_ca":false},{"name":"Richard Biener","is_ca":false},{"name":"C. Boisart","is_ca":false},{"name":"Rüdiger Heidemann","is_ca":false},{"name":"James M. Piret","is_ca":true},{"name":"Albert A. de Graaf","is_ca":false},{"name":"Konstantin Konstantinov","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.002365833529659626,"gpt":0.2192084149764002,"spread":0.2168425814467406,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004081816,0.0007424852,0.001143153,0.000529286,0.0008675081,0.0007246842,0.0006082893,0.0005479755,0.001344721],"category_scores_gemma":[0.0002146776,0.0002732195,0.0005714287,0.001259374,0.0004649732,0.0007595735,0.0003932401,0.0009253016,0.000357375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008729558,"about_ca_system_score_gemma":0.0005563479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005941343,"about_ca_topic_score_gemma":0.006876323,"domain_scores_codex":[0.9997254,0.00004365414,0.00002508384,0.00007957972,0.00006955386,0.00005672778],"domain_scores_gemma":[0.9998419,0.00004099489,0.00002352839,0.00002592318,0.00004076348,0.00002682835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004193014,0.00001929802,0.0002028978,0.0000310275,0.00001332536,0.00003501612,0.00003090503,0.0001436789,0.9979762,0.0001231434,0.00005536296,0.0009497839],"study_design_scores_gemma":[0.00003777786,0.0001241932,0.003719277,0.0000037971,0.00003970088,0.00006468137,0.00005011516,0.003071179,0.9912844,0.0001282213,0.00145508,0.00002168862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615517,0.001506642,0.02550647,0.0003413336,0.0001062681,0.0001335991,0.006801357,0.0002846009,0.003767931],"genre_scores_gemma":[0.9384995,0.002398003,0.04635502,0.0002692927,0.00006589077,0.0005829607,0.006845156,0.0003501828,0.004633955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005941343,"threshold_uncertainty_score":0.01181352,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W965551521","doi":"10.1016/j.ymben.2015.05.006","title":"On the feasibility of growth-coupled product synthesis in microbial strains","year":2015,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Metabolic engineering; Flux (metallurgy); Product (mathematics); Metabolic network; Biochemical engineering; Generalization; Biomass (ecology); Flux balance analysis; Coupling (piping); Yield (engineering); Constraint (computer-aided design); Production (economics); Metabolic flux analysis; Metabolite; Computer science; Mathematical optimization; Biological system; Mathematics; Chemistry; Biology; Engineering; Metabolism; Biochemistry; Physics; Ecology","authors":[{"name":"Steffen Klamt","is_ca":false},{"name":"Radhakrishnan Mahadevan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02066773224863912,"gpt":0.2300362213295567,"spread":0.2093684890809175,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008698111,0.0005289034,0.0002860182,0.0003762319,0.0003495134,0.0009086356,0.0006832282,0.000522423,0.001491632],"category_scores_gemma":[0.00132941,0.0002160734,0.0003213002,0.0003627832,0.0005550004,0.001243194,0.0008602541,0.001152919,0.0005512168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004262753,"about_ca_system_score_gemma":0.0003205861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008707088,"about_ca_topic_score_gemma":0.0007075419,"domain_scores_codex":[0.9995896,0.0001069004,0.00002778647,0.00006195711,0.0001527211,0.00006100958],"domain_scores_gemma":[0.999435,0.0003602973,0.00002262149,0.00006120887,0.00008960071,0.00003127863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001489618,0.000227943,0.0008675609,0.0004690099,0.00002899453,0.0002694505,0.0001201577,0.003844018,0.935061,0.01289187,0.0003803835,0.04434995],"study_design_scores_gemma":[0.00003349605,0.000481715,0.0007953021,0.00003277552,0.0000342494,0.0001142402,0.00006555757,0.009821294,0.9809575,0.002977096,0.004666033,0.0000208198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9131864,0.008031354,0.05651637,0.001206541,0.0001927681,0.0001108067,0.0004153351,0.0001191478,0.02022134],"genre_scores_gemma":[0.9760568,0.004274811,0.01688307,0.00009761181,0.00004747041,0.0000492034,0.0004658775,0.00005863305,0.002066548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491632,"threshold_uncertainty_score":0.004990041,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2605013004","doi":"10.1016/j.ymben.2017.04.001","title":"Metabolic engineering of Escherichia coli for the production of four-, five- and six-carbon lactams","year":2017,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Research Foundation of Korea; Petroleum Technology Alliance Canada","keywords":"Escherichia coli; Metabolic engineering; Production (economics); Microbiology; Biotechnology; Biochemistry; Chemistry; Biology; Enzyme; Gene; Economics","authors":[{"name":"Tong Un Chae","is_ca":false},{"name":"Yoo‐Sung Ko","is_ca":false},{"name":"Kyu-Sang Hwang","is_ca":false},{"name":"Sang Yup Lee","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009493623342342017,"gpt":0.2145293331690477,"spread":0.2050357098267057,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076178,0.0003917424,0.0002449438,0.0003400178,0.0001801549,0.0006585593,0.000306425,0.0002607666,0.0003923641],"category_scores_gemma":[0.0002725573,0.0001603483,0.0003132859,0.0004526124,0.0001592207,0.000166105,0.0003123292,0.0004970998,0.000268853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003892182,"about_ca_system_score_gemma":0.0004131038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001735155,"about_ca_topic_score_gemma":0.002395025,"domain_scores_codex":[0.999785,0.00004916157,0.00002614801,0.00001774314,0.00007543842,0.00004650065],"domain_scores_gemma":[0.9999275,0.00001316715,0.00001870755,0.000007952983,0.00001419059,0.00001845511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001746219,0.00008802701,0.0004962783,0.00004891551,0.00001165328,0.00009915017,0.0000230962,0.0007607438,0.9921962,0.0006557524,0.00004658603,0.005398975],"study_design_scores_gemma":[0.00001218254,0.0001180248,0.0008469048,0.000006408955,0.0000239057,0.0001500925,0.00003127548,0.002127286,0.9939027,0.00007607459,0.002696303,0.000008840731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830673,0.0007028549,0.01344511,0.0003070039,0.00004218782,0.00004603357,0.0002994826,0.00009557846,0.001994357],"genre_scores_gemma":[0.9833946,0.0008313594,0.01292889,0.00004413588,0.000004958103,0.00001870587,0.0003969817,0.00002750888,0.00235294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001735155,"threshold_uncertainty_score":0.003450096,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2028929834","doi":"10.1016/j.ymben.2013.10.010","title":"Balanced globin protein expression and heme biosynthesis improve production of human hemoglobin in Saccharomyces cerevisiae","year":2013,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Fondation Chalmers; Novo Nordisk Fonden; European Research Council; Knut och Alice Wallenbergs Stiftelse","keywords":"Hemoglobin; Heme; Globin; Biochemistry; Saccharomyces cerevisiae; Metabolic engineering; Biosynthesis; Yeast; Chemistry; Biology; Enzyme","authors":[{"name":"Lifang Liu","is_ca":false},{"name":"José L. Martínez","is_ca":false},{"name":"Zihe Liu","is_ca":false},{"name":"Dina Petranović","is_ca":false},{"name":"Jens Nielsen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00384602712520551,"gpt":0.1977138546597125,"spread":0.193867827534507,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990129,0.0004146282,0.0002662041,0.0002238607,0.000149673,0.0005653746,0.0002280396,0.0002287724,0.0007411463],"category_scores_gemma":[0.0002057104,0.0001609164,0.0001836798,0.0003769755,0.0001858221,0.0001672435,0.0002698445,0.0004231968,0.0002526885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004292101,"about_ca_system_score_gemma":0.0003141242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001856274,"about_ca_topic_score_gemma":0.002178309,"domain_scores_codex":[0.9998791,0.00002731093,0.00001611055,0.00002256443,0.00003528277,0.00001963118],"domain_scores_gemma":[0.9999212,0.00001789391,0.00001683532,0.00001088055,0.00001305471,0.0000200688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001835243,0.00004918694,0.0002861822,0.00002009934,0.000008535621,0.00003112168,0.00001594213,0.0004371232,0.9965304,0.0002085661,0.00005218206,0.002177254],"study_design_scores_gemma":[0.00001441373,0.00007242984,0.0007532359,0.000002583739,0.00002303995,0.00005833492,0.00002281374,0.002002684,0.9961945,0.00005984931,0.0007925499,0.000003575366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952416,0.0003369836,0.003309644,0.0001014031,0.00002066784,0.00001043476,0.0002602689,0.00009192267,0.0006270609],"genre_scores_gemma":[0.9948736,0.0002627326,0.003082339,0.00002770859,0.000005335449,0.000006573175,0.0003620167,0.00006074485,0.001318976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001856274,"threshold_uncertainty_score":0.003690898,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2017312906","doi":"10.1006/mben.2000.0158","title":"Choline Import into Chloroplasts Limits Glycine Betaine Synthesis in Tobacco: Analysis of Plants Engineered with a Chloroplastic or a Cytosolic Pathway","year":2000,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"GABA and Rice Research","field":"Agricultural and Biological Sciences","cited_by":86,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Plant Biotechnology Institute","funders":"U.S. Department of Agriculture; National Science Foundation","keywords":"Chloroplast; Cytosol; Glycine; Betaine; Biochemistry; Choline; Chemistry; Biology; Enzyme; Amino acid; Gene","authors":[{"name":"Michael L. Nuccio","is_ca":false},{"name":"Scott D. McNeil","is_ca":false},{"name":"Michael J. Ziemak","is_ca":false},{"name":"Andrew D. Hanson","is_ca":false},{"name":"R. K. Jain","is_ca":true},{"name":"Gopalan Selvaraj","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01260865925162456,"gpt":0.2168847111184579,"spread":0.2042760518668333,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002451172,0.0003736214,0.0004825444,0.0002591983,0.0003407471,0.000706131,0.00057707,0.0007870649,0.0006977039],"category_scores_gemma":[0.0002816128,0.0004587845,0.0004417217,0.0003610092,0.0006155127,0.0004322193,0.000344058,0.0009175485,0.0002554437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001590815,"about_ca_system_score_gemma":0.0006893648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008945616,"about_ca_topic_score_gemma":0.007881477,"domain_scores_codex":[0.9998028,0.00002154645,0.00002229381,0.00005372923,0.00005588539,0.00004381816],"domain_scores_gemma":[0.9995565,0.0001653806,0.00008646974,0.00004458567,0.00005228829,0.00009471698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000159668,0.00001504352,0.0002684766,0.00001345581,0.000005344369,0.00002580941,0.0000250001,0.00005241922,0.9991767,0.00008797291,0.000005264152,0.000164897],"study_design_scores_gemma":[0.00004024584,0.0001188756,0.01298891,0.000007069001,0.00006197914,0.0001882515,0.0001679112,0.00279142,0.9826809,0.0001172984,0.0008222667,0.00001488801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998212,0.000148601,0.0008485706,0.00005384769,0.000007762468,0.00001142459,0.0002598036,0.00002346393,0.0004347],"genre_scores_gemma":[0.9967467,0.000175399,0.0007276969,0.00004848035,0.000003349987,0.00002000601,0.0006293518,0.00007948961,0.001569547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008945616,"threshold_uncertainty_score":0.0177871,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2791075285","doi":"10.1016/j.ymben.2018.02.008","title":"Balancing the carbon flux distributions between the TCA cycle and glyoxylate shunt to produce glycolate at high yield and titer in Escherichia coli","year":2018,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Petroleum Technology Research Centre; Fundamental Research Funds for the Central Universities; Jiangnan University; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Glyoxylate cycle; Citric acid cycle; Isocitrate lyase; Biochemistry; Citrate synthase; Escherichia coli; Isocitrate dehydrogenase; Biology; Yield (engineering); Enzyme; Chemistry; Gene","authors":[{"name":"Yu Deng","is_ca":false},{"name":"Ning Ma","is_ca":false},{"name":"Kangjia Zhu","is_ca":false},{"name":"Yin Mao","is_ca":false},{"name":"Xuetuan Wei","is_ca":false},{"name":"Yunying Zhao","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004550777394507548,"gpt":0.1955490096001975,"spread":0.19099823220569,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002264206,0.0003909909,0.0003304809,0.0002223284,0.0002054646,0.001111383,0.0003167466,0.0002942796,0.0002569052],"category_scores_gemma":[0.0002476415,0.0002264052,0.0001497951,0.0003476691,0.000298353,0.0003535796,0.0003022524,0.0004130615,0.0001468992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008594643,"about_ca_system_score_gemma":0.0004749534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00187094,"about_ca_topic_score_gemma":0.003318267,"domain_scores_codex":[0.9998251,0.00003023481,0.00001509495,0.00003794473,0.00004692972,0.00004470436],"domain_scores_gemma":[0.9998827,0.00002585658,0.00003231509,0.00001096017,0.00002490764,0.00002325363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001485834,0.00004799948,0.0004643823,0.00002317401,0.000004990517,0.00001957905,0.00001533645,0.001380021,0.9954029,0.0003507258,0.00002108712,0.00212127],"study_design_scores_gemma":[0.00002033057,0.0001023886,0.0007890565,0.000003430142,0.00001490701,0.00002317806,0.00003929013,0.009126748,0.9892001,0.0001203044,0.0005500279,0.0000102674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920495,0.0002146291,0.006605858,0.00012669,0.00001830401,0.0000146066,0.00008097226,0.00004828642,0.0008410766],"genre_scores_gemma":[0.9954574,0.0001994781,0.003598559,0.00003135591,0.000003790974,0.000007212663,0.00005229891,0.00002424666,0.0006257937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00187094,"threshold_uncertainty_score":0.006235898,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1986556298","doi":"10.1016/j.ymben.2009.01.002","title":"Construction of a synthetic YdbK-dependent pyruvate:H2 pathway in Escherichia coli BL21(DE3)","year":2009,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Institute of Circulatory and Respiratory Health","keywords":"Escherichia coli; Bacillus subtilis; Clostridium acetobutylicum; Fermentation; Biochemistry; Clostridium; Metabolic engineering; Thiamine pyrophosphate; Yield (engineering); Ferredoxin; Cofactor; Chemistry; Recombinant DNA; Strain (injury); Biosynthesis; Bacteria; Biology; Enzyme; Ethanol; Butanol; Gene","authors":[{"name":"M. Akhtar","is_ca":false},{"name":"Patrik R. Jones","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003930096092462425,"gpt":0.187787433028949,"spread":0.1838573369364866,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005782053,0.0009048178,0.0008988848,0.000520093,0.0004257577,0.0007142254,0.001086125,0.0006032616,0.001674708],"category_scores_gemma":[0.0002917083,0.0005192967,0.0005977415,0.00110596,0.0003214004,0.0005028613,0.0006701528,0.001471314,0.001723441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007778888,"about_ca_system_score_gemma":0.0006804107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001584015,"about_ca_topic_score_gemma":0.001686065,"domain_scores_codex":[0.9995481,0.00008144345,0.00007289961,0.00007370921,0.0001410488,0.00008269523],"domain_scores_gemma":[0.9997576,0.00004994477,0.00004569664,0.0000379712,0.00003435319,0.00007446889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000223571,0.0001205396,0.0001902585,0.0001361524,0.00002044623,0.00008053301,0.0000290762,0.0002245167,0.9961597,0.0003891604,0.0001425056,0.002283514],"study_design_scores_gemma":[0.00005384379,0.0001192587,0.0007865011,0.000009489067,0.00002430181,0.0001026875,0.00002471848,0.0008950341,0.9939477,0.00008256776,0.003939416,0.00001442406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8662478,0.001052972,0.1076416,0.0007067809,0.0004127492,0.001380366,0.01610289,0.001255527,0.005199244],"genre_scores_gemma":[0.8195959,0.001389443,0.1297177,0.0002601267,0.00003839888,0.0007314608,0.0334514,0.0006139271,0.01420157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001674708,"threshold_uncertainty_score":0.005643964,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2060000025","doi":"10.1016/j.ymben.2003.10.004","title":"A critical perspective of the use of 13C-isotopomer analysis by GCMS and NMR as applied to cardiac metabolism","year":2003,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; National Science Foundation","keywords":"Isotopomers; Citric acid cycle; Citric acid; Metabolism; Metabolic flux analysis; Flux (metallurgy); Tricarboxylic acid; Isotope; Chemistry; Carbon-13 NMR; Stable isotope ratio; Biochemistry; Stereochemistry; Organic chemistry; Physics","authors":[{"name":"Christine Des Rosiers","is_ca":true},{"name":"Steven G. Lloyd","is_ca":false},{"name":"Blandine Comte","is_ca":true},{"name":"John C. Chatham","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007251452780998544,"gpt":0.2298329993814312,"spread":0.2225815466004327,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03130214,0.002488764,0.004108827,0.003867197,0.002390914,0.00997493,0.006645471,0.01099339,0.003811205],"category_scores_gemma":[0.01860951,0.001063933,0.001554446,0.001501972,0.02162268,0.01412704,0.003028009,0.01473691,0.001728293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00479904,"about_ca_system_score_gemma":0.005967729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005092314,"about_ca_topic_score_gemma":0.006310814,"domain_scores_codex":[0.9941897,0.002932232,0.000435706,0.0007101667,0.001398958,0.0003332],"domain_scores_gemma":[0.9670482,0.02115089,0.0007395991,0.002601032,0.006717296,0.001742973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00120975,0.0005184247,0.002061747,0.004237575,0.0005437118,0.002710361,0.002192262,0.004280184,0.03837198,0.520474,0.1136006,0.3097993],"study_design_scores_gemma":[0.0001770145,0.0008702397,0.00173143,0.001712556,0.0002345489,0.002367542,0.002150184,0.003835447,0.01413234,0.3238711,0.6484567,0.0004608963],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005927736,0.4851643,0.1358748,0.3058726,0.0387796,0.0003133226,0.0003544877,0.0007600962,0.02695295],"genre_scores_gemma":[0.1034277,0.4884436,0.1899759,0.1156656,0.08240831,0.001064937,0.000206492,0.0005486601,0.01825903],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03130214,"threshold_uncertainty_score":0.1655435,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2076865861","doi":"10.1016/j.ymben.2005.02.003","title":"Increased levels of erucic acid in Brassica carinata by co-suppression and antisense repression of the endogenous FAD2 gene","year":2005,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Plant Biotechnology Institute","funders":"","keywords":"Erucic acid; Brassica carinata; Transgene; Endogeny; Brassica; Biochemistry; Biology; Fatty acid; Gene; Food science; Botany","authors":[{"name":"Ashok Jadhav","is_ca":true},{"name":"Vesna Katavić","is_ca":true},{"name":"Elizabeth‐France Marillia","is_ca":true},{"name":"E. Michael Giblin","is_ca":true},{"name":"Dennis L. Barton","is_ca":true},{"name":"Arvind Kumar","is_ca":true},{"name":"Cory Sonntag","is_ca":true},{"name":"Vivijan Babic","is_ca":true},{"name":"Wilfred A. Keller","is_ca":true},{"name":"David C. Taylor","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00947418628799758,"gpt":0.2139559387901282,"spread":0.2044817525021306,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001721051,0.0008346488,0.0004917868,0.0005607498,0.0003053204,0.0006272598,0.0004271656,0.0004735565,0.001290414],"category_scores_gemma":[0.0001713162,0.0004054592,0.0003516164,0.000321706,0.000362682,0.0003352725,0.0004100052,0.0008519686,0.000476609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008894373,"about_ca_system_score_gemma":0.0003546092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004059692,"about_ca_topic_score_gemma":0.005035619,"domain_scores_codex":[0.9997805,0.00002974987,0.0000203964,0.00006827292,0.00004678347,0.00005428754],"domain_scores_gemma":[0.9996709,0.0000667412,0.00007081969,0.00005763011,0.00004470463,0.00008931853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006248254,0.000003849146,0.00003502517,0.000007319011,0.00000173823,0.00001193697,0.000008530563,0.00001618855,0.9996556,0.00003587592,0.000005794791,0.0001557],"study_design_scores_gemma":[0.00001972111,0.00007398122,0.002486194,0.000003139711,0.00001978618,0.00007972081,0.00005021258,0.0006413746,0.9951172,0.00004938996,0.00144874,0.00001057849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940616,0.001231695,0.002377179,0.0002134504,0.00004900149,0.00001151775,0.0005186217,0.000266066,0.001270637],"genre_scores_gemma":[0.9921989,0.000330696,0.001060755,0.00008048875,0.00001068568,0.00001839347,0.0008846686,0.0001174491,0.005298026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004059692,"threshold_uncertainty_score":0.008072138,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2086329572","doi":"10.1016/j.ymben.2005.08.002","title":"Metabolic flux analysis of HEK-293 cells in perfusion cultures for the production of adenoviral vectors","year":2005,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Polytechnique Montréal","funders":"","keywords":"Metabolic flux analysis; Intracellular; Flux (metallurgy); Cell culture; Perfusion; Glycolysis; Cell biology; Cell; Metabolic engineering; Biology; Metabolism; Chemistry; Biochemistry; Gene; Internal medicine; Genetics; Medicine","authors":[{"name":"Olivier Henry","is_ca":true},{"name":"Pascal Perrier","is_ca":true},{"name":"Amine Kamen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.005873366629491978,"gpt":0.2441833618699019,"spread":0.2383099952404099,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004741636,0.0006255017,0.001211679,0.0004769949,0.0006607906,0.0008246652,0.0006009492,0.0004924688,0.001559503],"category_scores_gemma":[0.0002370675,0.0002863783,0.0006163747,0.001135258,0.0003036147,0.0007774119,0.0003376208,0.001441853,0.0005818972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008302895,"about_ca_system_score_gemma":0.0005159282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003342634,"about_ca_topic_score_gemma":0.003497705,"domain_scores_codex":[0.9995782,0.00006322648,0.00003599074,0.0001110982,0.0001505191,0.00006105265],"domain_scores_gemma":[0.9998125,0.00007111319,0.0000256143,0.00002181696,0.00004570452,0.00002330301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001888121,0.00002740636,0.0001431873,0.00002902251,0.000006774312,0.00002456824,0.00002420566,0.000111253,0.9984749,0.0001595899,0.00003702348,0.0007733188],"study_design_scores_gemma":[0.00001498931,0.00008350908,0.002531874,0.00000506983,0.00001963576,0.00006173032,0.00003306128,0.003188782,0.9922524,0.0001160451,0.001682034,0.00001087601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9107689,0.001502261,0.06844568,0.0002947414,0.0001336475,0.000336938,0.01113123,0.0004329201,0.006953597],"genre_scores_gemma":[0.8832791,0.002530446,0.08376381,0.0002128646,0.00005145045,0.0008237585,0.01793181,0.0005486965,0.01085805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003342634,"threshold_uncertainty_score":0.006646335,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2800094547","doi":"10.1016/j.ymben.2018.04.013","title":"Engineering a short, aldolase-based pathway for (R)-1,3-butanediol production in Escherichia coli","year":2018,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Aldolase A; Metabolic engineering; Escherichia coli; Biochemistry; Chemistry; Acetoin; Yield (engineering); Glyceraldehyde; Acetaldehyde; Fermentation; Corn steep liquor; Ethanol; Enzyme; Dehydrogenase","authors":[{"name":"Kayla Nemr","is_ca":true},{"name":"Jonas E. N. Müller","is_ca":true},{"name":"Jeong Chan Joo","is_ca":true},{"name":"Pratish Gawand","is_ca":true},{"name":"Ruhi Choudhary","is_ca":true},{"name":"Burton Mendonca","is_ca":true},{"name":"Shuyi Lu","is_ca":true},{"name":"Xiuyan Yu","is_ca":true},{"name":"Alexander F. Yakunin","is_ca":true},{"name":"Radhakrishnan Mahadevan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007826016603047757,"gpt":0.2120298635099626,"spread":0.2042038469069148,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146163,0.0005598182,0.0004245996,0.0003105096,0.000263158,0.0006738456,0.0004098118,0.0004631988,0.0007283312],"category_scores_gemma":[0.0002688189,0.0002069341,0.0004715163,0.0005586834,0.0001800282,0.0004532429,0.0004347589,0.000965496,0.0007637314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004880113,"about_ca_system_score_gemma":0.0007957614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001610097,"about_ca_topic_score_gemma":0.002624274,"domain_scores_codex":[0.9998387,0.00001756664,0.00002314645,0.00002605694,0.00005003034,0.0000444326],"domain_scores_gemma":[0.9998488,0.00002045815,0.00002528746,0.00001760716,0.00003615904,0.00005164145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001129703,0.00007722768,0.0002117073,0.0001006308,0.00001095952,0.0001355797,0.00002012279,0.0005457585,0.9933308,0.0004911735,0.00007658709,0.004886375],"study_design_scores_gemma":[0.00001317155,0.0001477763,0.000433107,0.000008510852,0.00002316285,0.0001693519,0.00003995035,0.001052585,0.9942424,0.0001999915,0.003658269,0.00001175202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9156489,0.00169082,0.0756706,0.0008496899,0.0003657907,0.0002339886,0.001761678,0.0004772317,0.0033013],"genre_scores_gemma":[0.8983987,0.002069233,0.08755997,0.0002431556,0.00002306884,0.00009867035,0.002985668,0.0001529474,0.008468574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001610097,"threshold_uncertainty_score":0.003540814,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2901800824","doi":"10.1016/j.ymben.2018.11.010","title":"Yeast chemogenomic screen identifies distinct metabolic pathways required to tolerate exposure to phenolic fermentation inhibitors ferulic acid, 4-hydroxybenzoic acid and coniferyl aldehyde","year":2018,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":59,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ferulic acid; Biochemistry; Yeast; Fermentation; Chemistry; Phenylpropanoid; Metabolic engineering; Monolignol; Enzyme; Biosynthesis","authors":[{"name":"Eugene Fletcher","is_ca":true},{"name":"Kai Gao","is_ca":true},{"name":"Kevin Mercurio","is_ca":true},{"name":"Mariam Ali","is_ca":true},{"name":"Kristin Baetz","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01232697262732882,"gpt":0.2053675791188428,"spread":0.193040606491514,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009562742,0.0004483769,0.0004102534,0.0003296897,0.0001216037,0.0002854964,0.0002566993,0.0002056761,0.0006496521],"category_scores_gemma":[0.0001281991,0.0001333038,0.0003762238,0.0003361681,0.000109707,0.0001245301,0.0002196748,0.0002698733,0.0002100889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000220717,"about_ca_system_score_gemma":0.0002624812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001811329,"about_ca_topic_score_gemma":0.001910246,"domain_scores_codex":[0.9998721,0.00001065337,0.00001605605,0.00003114262,0.00004519477,0.00002480771],"domain_scores_gemma":[0.9998883,0.00001875998,0.00003444893,0.00001381367,0.00002239511,0.00002231465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005167105,0.00002439288,0.0003678795,0.00001604225,0.000004376038,0.00003433137,0.000006162663,0.00005643253,0.9986965,0.0000226426,0.0000166124,0.0007030205],"study_design_scores_gemma":[0.00001317349,0.0002922189,0.01885019,0.000005377358,0.00004497184,0.0002552888,0.00008404739,0.001446386,0.9777269,0.00003074395,0.001242884,0.000007816418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932277,0.0003887856,0.003245489,0.00008150579,0.00001234668,0.00004937602,0.00229934,0.0001310765,0.0005644414],"genre_scores_gemma":[0.9874779,0.0005668523,0.004349906,0.00008026307,0.000005006936,0.00006294425,0.005332952,0.00005277609,0.002071325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811329,"threshold_uncertainty_score":0.003601551,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1972993933","doi":"10.1016/j.ymben.2013.08.003","title":"Novel approach to engineer strains for simultaneous sugar utilization","year":2013,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Concordia University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Xylose; Catabolite repression; Metabolic engineering; Biomass (ecology); Lignocellulosic biomass; Biofuel; Sugar; Raw material; Fermentation; Microorganism; Biochemical engineering; Biochemistry; Chemistry; Biotechnology; Food science; Pulp and paper industry; Biology; Mutant; Enzyme; Bacteria; Gene; Organic chemistry; Engineering; Agronomy; Genetics","authors":[{"name":"Pratish Gawand","is_ca":true},{"name":"Patrick Hyland","is_ca":true},{"name":"Andrew Ekins","is_ca":true},{"name":"Vincent J. J. Martin","is_ca":true},{"name":"Radhakrishnan Mahadevan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01497864351123455,"gpt":0.2220141836325286,"spread":0.2070355401212941,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002981619,0.001185416,0.0008470196,0.000669937,0.0004303766,0.0008882183,0.0007426048,0.00070116,0.0007928658],"category_scores_gemma":[0.0002369412,0.0004456395,0.000669748,0.000614614,0.0003136033,0.0007611513,0.001074189,0.001979416,0.000742716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000375266,"about_ca_system_score_gemma":0.0005666391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000532135,"about_ca_topic_score_gemma":0.001137779,"domain_scores_codex":[0.9996431,0.00002994085,0.0000371885,0.00008196876,0.0001667026,0.00004105689],"domain_scores_gemma":[0.9998578,0.00001752031,0.00002920079,0.00003507705,0.00002912283,0.00003132718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002223174,0.00007675815,0.0000515977,0.00003903951,0.000007304151,0.00005301222,0.00001802996,0.00009753471,0.9925092,0.0003890218,0.00007019891,0.006666067],"study_design_scores_gemma":[0.00002492776,0.0002494901,0.0004038746,0.00001093239,0.00004617578,0.0005711572,0.00003675928,0.001813085,0.9881357,0.0003736835,0.008311002,0.00002309711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4920115,0.003698605,0.4896386,0.001313222,0.0007347512,0.0005468983,0.001106662,0.001752759,0.009196961],"genre_scores_gemma":[0.5771941,0.005071335,0.3993314,0.000371891,0.0001103567,0.0005703609,0.002674453,0.0003745134,0.01430166],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001185416,"threshold_uncertainty_score":0.0027228,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2036597230","doi":"10.1016/j.ymben.2011.05.004","title":"Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase","year":2011,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Biotechnology Research Institute; National Research Council Canada; Polytechnique Montréal","funders":"","keywords":"HEK 293 cells; Pyruvate carboxylase; Biochemistry; Metabolism; Metabolome; Intracellular; Chemistry; Metabolite; Yield (engineering); Biology; Enzyme; Gene","authors":[{"name":"Olivier Henry","is_ca":true},{"name":"Yves Durocher","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00964560932368459,"gpt":0.210870114502545,"spread":0.2012245051788604,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003193899,0.0005133809,0.0004498542,0.0002363581,0.0002229238,0.0006796275,0.0003748276,0.0004159541,0.0008322409],"category_scores_gemma":[0.0001717326,0.0002685502,0.0004041972,0.0004116817,0.0002827233,0.0004666879,0.0003371052,0.001255747,0.000823179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005471691,"about_ca_system_score_gemma":0.0002459288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007702755,"about_ca_topic_score_gemma":0.0007976134,"domain_scores_codex":[0.9997692,0.0000543226,0.00002690985,0.00003319515,0.00007659326,0.00003977997],"domain_scores_gemma":[0.9998642,0.00004602979,0.00002559135,0.00002785258,0.0000168294,0.00001939482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005297461,0.00001355767,0.00004140404,0.00002246443,0.000003733916,0.00003437734,0.00001715105,0.00007077073,0.9989684,0.0002079792,0.00003057112,0.0005366921],"study_design_scores_gemma":[0.00001355411,0.00005475695,0.0004620098,0.000003579476,0.000009907701,0.0001090954,0.00001122541,0.0009409063,0.9959196,0.00004413351,0.002427155,0.000004168023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531527,0.001627791,0.03634152,0.0003228695,0.0001649559,0.0001897288,0.002919634,0.0003574181,0.004923318],"genre_scores_gemma":[0.9574614,0.00130336,0.02587916,0.00007639736,0.00003262289,0.00009085936,0.004434551,0.000162771,0.0105588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008322409,"threshold_uncertainty_score":0.003970027,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2038624513","doi":"10.1016/j.ymben.2011.09.009","title":"Identification of bottlenecks in Escherichia coli engineered for the production of CoQ10","year":2011,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Concordia University","funders":"","keywords":"Escherichia coli; Identification (biology); Computational biology; Production (economics); Biotechnology; Biology; Chemistry; Biochemistry; Gene; Economics","authors":[{"name":"Corinne P. Cluis","is_ca":false},{"name":"Andrew Ekins","is_ca":true},{"name":"Lauren Narcross","is_ca":true},{"name":"Heng Jiang","is_ca":true},{"name":"Nicholas D. Gold","is_ca":true},{"name":"Adam M. Burja","is_ca":false},{"name":"Vincent J. J. Martin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01036927668954256,"gpt":0.2156115893176582,"spread":0.2052423126281157,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004952132,0.000670531,0.0005670465,0.0004855641,0.0003397499,0.0009606398,0.0007147234,0.0004922077,0.0009919669],"category_scores_gemma":[0.001300324,0.0004084603,0.0002834998,0.0005214093,0.0004774876,0.0004820466,0.0005758429,0.0008791764,0.0003483695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00120454,"about_ca_system_score_gemma":0.0008753698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01152743,"about_ca_topic_score_gemma":0.006776988,"domain_scores_codex":[0.9994672,0.00009140242,0.00006028393,0.00009447182,0.0001670093,0.0001196037],"domain_scores_gemma":[0.9990271,0.0003609988,0.0001965165,0.00008435908,0.0001995747,0.0001314101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001699236,0.0000897781,0.001026197,0.00002771812,0.000006880083,0.00006312066,0.00003543754,0.0001644731,0.9966859,0.000117097,0.00004603925,0.001567347],"study_design_scores_gemma":[0.000009570329,0.0001127994,0.002904774,0.000005340883,0.00001420001,0.0001035096,0.00007244116,0.001425547,0.994926,0.00003780961,0.0003772684,0.00001066166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949004,0.0001770713,0.003885886,0.0001000265,0.00001469893,0.0000321334,0.0002917058,0.000133418,0.0004646968],"genre_scores_gemma":[0.9942995,0.0002684173,0.003645966,0.00005066088,0.000003956243,0.00003512712,0.000489387,0.0001200261,0.001086882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01152743,"threshold_uncertainty_score":0.02292067,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3047419816","doi":"10.1016/j.ymben.2020.07.008","title":"Improving CRISPR/Cas9-mediated genome editing efficiency in Yarrowia lipolytica using direct tRNA-sgRNA fusions","year":2020,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Université Laval; U.S. Department of Energy","keywords":"Yarrowia; Genome editing; CRISPR; Cas9; Biology; Guide RNA; Gene; Subgenomic mRNA; Genetics; Computational biology; Saccharomyces cerevisiae; Homologous recombination; RNA editing; RNA","authors":[{"name":"Ahmad Mohammad Abdel‐Mawgoud","is_ca":true},{"name":"George Stephanopoulos","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008983810513779241,"gpt":0.2512341432986118,"spread":0.2422503327848325,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009319808,0.0005533738,0.0007808566,0.0003845757,0.0002904761,0.001050775,0.0006671682,0.0005514104,0.001013886],"category_scores_gemma":[0.0005965479,0.0002653578,0.0005645959,0.000402973,0.0003163925,0.0004043001,0.0006669139,0.001180176,0.000844257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006752972,"about_ca_system_score_gemma":0.0003457325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009006689,"about_ca_topic_score_gemma":0.001169616,"domain_scores_codex":[0.999157,0.0001187242,0.0001566085,0.0001562028,0.00028884,0.0001226834],"domain_scores_gemma":[0.9995953,0.00009592911,0.0001104931,0.00007381004,0.00007051452,0.00005392298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002774904,0.00001243695,0.00007129626,0.00001823934,0.000005294376,0.00001902976,0.000007032932,0.00007445722,0.9987528,0.00005335904,0.00001820603,0.0009400698],"study_design_scores_gemma":[0.000004792534,0.00002394784,0.0005758288,0.000002572485,0.00001296959,0.00005638694,0.000009312986,0.001185606,0.9972515,0.00002007622,0.0008501753,0.000007023089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481742,0.001224947,0.0463113,0.0002393644,0.0001023708,0.00008123523,0.0006678338,0.001142115,0.002056547],"genre_scores_gemma":[0.9755539,0.0006125034,0.01909295,0.0000592409,0.00001014338,0.00004696716,0.0009195028,0.0002575193,0.003447463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050775,"threshold_uncertainty_score":0.004928827,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3034771267","doi":"10.1016/j.ymben.2020.06.004","title":"Development of a clostridia-based cell-free system for prototyping genetic parts and metabolic pathways","year":2020,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Biological and Environmental Research; Office of Science; Joint Genome Institute; Suncor Energy Incorporated; U.S. Department of Energy","keywords":"Clostridia; Bioproducts; Synthetic biology; Computational biology; Metabolic engineering; Biochemical engineering; Biology; Thermophile; Biotechnology; Gene; Biochemistry; Engineering; Bacteria; Genetics; Biofuel","authors":[{"name":"Antje Krüger","is_ca":false},{"name":"Alexander P. Mueller","is_ca":false},{"name":"Grant A. Rybnicky","is_ca":false},{"name":"Nancy L. Engle","is_ca":false},{"name":"Zamin K. Yang","is_ca":false},{"name":"Timothy J. Tschaplinski","is_ca":false},{"name":"Séan D. Simpson","is_ca":false},{"name":"Michael Köpke","is_ca":false},{"name":"Michael C. Jewett","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01169620806709643,"gpt":0.1862353408756765,"spread":0.1745391328085801,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006099761,0.001047537,0.0007136355,0.0005922768,0.0006838434,0.0007804872,0.001316572,0.0008160656,0.002068081],"category_scores_gemma":[0.0004506578,0.000509897,0.0005085187,0.0005133961,0.0002518587,0.0006708426,0.0007402326,0.001405043,0.001462732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004639591,"about_ca_system_score_gemma":0.001029831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001351883,"about_ca_topic_score_gemma":0.001502874,"domain_scores_codex":[0.999487,0.00004900329,0.00003629144,0.00009208934,0.0002784174,0.00005709739],"domain_scores_gemma":[0.999724,0.00004674502,0.0000312843,0.00005057755,0.0000582309,0.00008901925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006205569,0.00005995373,0.0001005668,0.00007146082,0.00000798318,0.00005587071,0.00001297212,0.0005017644,0.9935803,0.0003105526,0.0001907425,0.005045787],"study_design_scores_gemma":[0.00003893054,0.0001724563,0.0006848972,0.00001242922,0.00001796426,0.0001568823,0.000009620383,0.005152493,0.9864361,0.0001277817,0.007164097,0.00002643718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5042174,0.001281024,0.4672671,0.0005071458,0.0005698508,0.001386122,0.005594225,0.01072706,0.008450137],"genre_scores_gemma":[0.4744703,0.0008449082,0.504673,0.0001217318,0.0000326141,0.001144128,0.008592578,0.0008060448,0.00931455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002068081,"threshold_uncertainty_score":0.006918371,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2032311175","doi":"10.1016/j.ymben.2009.06.001","title":"Quantification of statin effects on hepatic cholesterol synthesis by transient 13C-flux analysis","year":2009,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung; Atlantic Canada Opportunities Agency; Robert Bosch Stiftung","keywords":"Flux (metallurgy); Statin; Metabolic flux analysis; Transient (computer programming); Cholesterol; Atorvastatin; Chemistry; Internal medicine; Biochemistry; Medicine; Computer science; Metabolism; Organic chemistry","authors":[{"name":"Klaus Maier","is_ca":false},{"name":"Ute Hofmann","is_ca":false},{"name":"Alexander Bauer","is_ca":false},{"name":"Anja Niebel","is_ca":false},{"name":"Gabriele Vacun","is_ca":false},{"name":"Matthias Reuß","is_ca":false},{"name":"Klaus Mauch","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009348703495255458,"gpt":0.2395474225735756,"spread":0.2301987190783201,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007722739,0.0007073589,0.001113346,0.0005500834,0.0007219793,0.001011005,0.0004469472,0.000545731,0.002222744],"category_scores_gemma":[0.0006140159,0.0003542901,0.0006780121,0.001069942,0.0008929567,0.0005581224,0.000438122,0.0009321553,0.0003718768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001387605,"about_ca_system_score_gemma":0.001154585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006846718,"about_ca_topic_score_gemma":0.009472098,"domain_scores_codex":[0.9995389,0.00009108092,0.00003866043,0.0001114887,0.0001169928,0.0001029437],"domain_scores_gemma":[0.999494,0.0001761804,0.00006777997,0.00009166379,0.0001029155,0.00006747716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002530297,0.00007732202,0.0006397247,0.00008840075,0.00003703182,0.00002945785,0.00004574145,0.0005059172,0.992474,0.0003658076,0.0001051824,0.003100943],"study_design_scores_gemma":[0.00004227605,0.0001518363,0.001759883,0.000003129042,0.00003686138,0.00001550324,0.00001790898,0.002612597,0.9946824,0.0000542235,0.0006129111,0.00001041601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610746,0.001643173,0.02980057,0.0002711214,0.0001365121,0.0001787142,0.003881474,0.0003321801,0.002681561],"genre_scores_gemma":[0.9609345,0.001289379,0.02825435,0.0002110634,0.00004455295,0.0004799595,0.003425564,0.0002687694,0.00509193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006846718,"threshold_uncertainty_score":0.01361376,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2033384339","doi":"10.1006/mben.2000.0152","title":"Human 293 Cell Metabolism in Low Glutamine-Supplied Culture: Interpretation of Metabolic Changes through Metabolic Flux Analysis","year":2000,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Polytechnique Montréal","funders":"","keywords":"Glutamine; Metabolic flux analysis; Fed-batch culture; Ammonia; Metabolism; Flux (metallurgy); Amino acid; Biochemistry; Metabolic pathway; Chemistry; Ammonia production; Biology; Chromatography; Fermentation","authors":[{"name":"Isabelle Nadeau","is_ca":true},{"name":"J. Sabatié","is_ca":false},{"name":"M. Koehl","is_ca":false},{"name":"Pascal Perrier","is_ca":true},{"name":"Amine Kamen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.004420178154851739,"gpt":0.2326222175139065,"spread":0.2282020393590548,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622994,0.0002207151,0.0004627412,0.000212005,0.0002874802,0.0004050797,0.0002028109,0.0002334637,0.001042437],"category_scores_gemma":[0.0001183903,0.000111136,0.0002145072,0.0007691852,0.000212422,0.0002525575,0.0001286153,0.0003914879,0.000404345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003122968,"about_ca_system_score_gemma":0.0003089354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00310896,"about_ca_topic_score_gemma":0.003234037,"domain_scores_codex":[0.999886,0.00001988043,0.000008893435,0.00003244,0.00003396403,0.00001872901],"domain_scores_gemma":[0.9999431,0.0000183682,0.000006429043,0.000008841257,0.0000158221,0.000007301377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005726008,0.00001525787,0.000653779,0.00004164915,0.000008590886,0.00006049452,0.00003112756,0.0002666314,0.9963386,0.0001465742,0.00005070975,0.001814038],"study_design_scores_gemma":[0.00001264317,0.00009962943,0.00587853,0.00000314034,0.00002660191,0.0001238253,0.00003847609,0.002830377,0.9892939,0.0001218563,0.001561797,0.000009145358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961214,0.00181801,0.02783724,0.0001333442,0.00007281618,0.00005294408,0.005637454,0.000149435,0.003084816],"genre_scores_gemma":[0.9698429,0.001612503,0.01951444,0.00005870966,0.00001003986,0.0001061813,0.006360405,0.00008764247,0.002407051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00310896,"threshold_uncertainty_score":0.006181717,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2004194037","doi":"10.1016/j.ymben.2014.05.001","title":"Two-stage transcriptional reprogramming in Saccharomyces cerevisiae for optimizing ethanol production from xylose","year":2014,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":50,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"Capital Normal University","keywords":"Xylose; Saccharomyces cerevisiae; Ethanol fuel; Reprogramming; Production (economics); Ethanol; Yeast; Chemistry; Fed-batch culture; Biochemistry; Fermentation; Gene; Economics; Microeconomics","authors":[{"name":"Limin Cao","is_ca":true},{"name":"Xingliang Tang","is_ca":false},{"name":"Xinyuan Zhang","is_ca":false},{"name":"Jingtao Zhang","is_ca":false},{"name":"Xue-Lei Tian","is_ca":false},{"name":"Jingyu Wang","is_ca":false},{"name":"Mingyong Xiong","is_ca":false},{"name":"Wei Xiao","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01393181421194961,"gpt":0.2213966285844171,"spread":0.2074648143724675,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146214,0.0004279357,0.0003190509,0.0001606374,0.0001389706,0.0005885897,0.0002935586,0.0002078916,0.0006689251],"category_scores_gemma":[0.0001465675,0.0001513415,0.0003641513,0.000198177,0.0001624391,0.0002796356,0.0003869617,0.0005664404,0.0002478706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003605971,"about_ca_system_score_gemma":0.0002407624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008837045,"about_ca_topic_score_gemma":0.001582701,"domain_scores_codex":[0.9998851,0.00001554497,0.00001509485,0.0000297912,0.00003380224,0.00002058222],"domain_scores_gemma":[0.9999529,0.000008893149,0.00001002708,0.000009867033,0.000009615859,0.000008643687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000078165,0.0000391238,0.0001633738,0.00002679974,0.000004540698,0.00002942761,0.00001929391,0.0003494094,0.9946958,0.0002658544,0.00003494935,0.004293329],"study_design_scores_gemma":[0.000009201174,0.00007916888,0.0007412042,0.000003369653,0.00001466432,0.00004616854,0.0000258706,0.002826822,0.9943755,0.00009334095,0.001774487,0.00001015761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754897,0.0008629046,0.01978616,0.0001480549,0.0001155355,0.00006833245,0.0005696759,0.0002515997,0.002707815],"genre_scores_gemma":[0.9866404,0.0005393763,0.008478822,0.00003918129,0.000008876273,0.00003527606,0.0004815008,0.00006954205,0.003707203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008837045,"threshold_uncertainty_score":0.002616286,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3211833564","doi":"10.1016/j.ymben.2021.11.005","title":"Systematic identification of Ocimum sanctum sesquiterpenoid synthases and (−)-eremophilene overproduction in engineered yeast","year":2021,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Ocimum; Biology; Yeast; Metabolic engineering; Natural product; Biochemistry; Gene; Biotechnology; Botany","authors":[{"name":"Xiaomin Deng","is_ca":true},{"name":"Bin Shi","is_ca":false},{"name":"Ziling Ye","is_ca":false},{"name":"Man Huang","is_ca":false},{"name":"Rong Chen","is_ca":false},{"name":"You‐Sheng Cai","is_ca":false},{"name":"Zhaolin Kuang","is_ca":false},{"name":"Xiang Sun","is_ca":false},{"name":"Guangkai Bian","is_ca":false},{"name":"Zixin Deng","is_ca":false},{"name":"Tiangang Liu","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003612368732684148,"gpt":0.1874161797600186,"spread":0.1838038110273345,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000222385,0.0006312684,0.000356044,0.0005005219,0.0001838862,0.0004947407,0.0003357138,0.0002171602,0.0004875449],"category_scores_gemma":[0.0002921091,0.0003456459,0.0004387105,0.000569443,0.0002019682,0.0002234799,0.0005639481,0.0005765029,0.0004743675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000278813,"about_ca_system_score_gemma":0.000332972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007871073,"about_ca_topic_score_gemma":0.001321618,"domain_scores_codex":[0.9997883,0.00002069521,0.00003475265,0.00003908989,0.00008617603,0.00003092335],"domain_scores_gemma":[0.9996794,0.00006353627,0.0001001101,0.00006585289,0.00005106212,0.00004004542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004511273,0.00001349743,0.0002020841,0.00002469015,0.000005093651,0.0000376622,0.00001171934,0.00005500982,0.9978659,0.00005505285,0.00001115682,0.001673112],"study_design_scores_gemma":[0.000006501146,0.00006405769,0.003077409,0.000007043709,0.00003622599,0.0002384262,0.00004716026,0.0004044214,0.994356,0.00004156765,0.001714171,0.000006950701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98322,0.001212442,0.01205731,0.0001409916,0.00004333362,0.00007238561,0.00170976,0.00025358,0.001290251],"genre_scores_gemma":[0.9767294,0.00160595,0.01350468,0.00008959774,0.00001338712,0.00005502938,0.004585845,0.0001520668,0.003264023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007871073,"threshold_uncertainty_score":0.002022982,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2899363545","doi":"10.1016/j.ymben.2018.10.007","title":"Upgrade of wood sugar d-xylose to a value-added nutraceutical by in vitro metabolic engineering","year":2018,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":48,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Center for Advanced Study, University of Illinois at Urbana-Champaign; Henan Agricultural University; National Natural Science Foundation of China; Ministry of Agriculture - Saskatchewan","keywords":"Xylose; Chemistry; Xylose metabolism; Pentose; Biochemistry; Thermotoga maritima; Fermentation","authors":[{"name":"Kun Cheng","is_ca":false},{"name":"Wenming Zheng","is_ca":false},{"name":"Hongge Chen","is_ca":false},{"name":"Y.‐H. Percival Zhang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007260907814361764,"gpt":0.2094110915454226,"spread":0.2021501837310609,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464074,0.0005351586,0.0002184415,0.0002127039,0.0001411562,0.0005371852,0.000205045,0.0002249614,0.0003970819],"category_scores_gemma":[0.0001179609,0.0001606522,0.0004329764,0.0002950696,0.0001554078,0.0003929658,0.0003306876,0.0005454703,0.0002648101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293903,"about_ca_system_score_gemma":0.0002187616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007372954,"about_ca_topic_score_gemma":0.001152434,"domain_scores_codex":[0.9999038,0.00001937553,0.000009732655,0.00001942132,0.00002177868,0.00002575187],"domain_scores_gemma":[0.9999609,0.000006299456,0.00000993758,0.000006328058,0.000007351541,0.000009219096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000382956,0.00003467142,0.0001237676,0.00003739911,0.000007967598,0.00004792985,0.00001211863,0.0003617599,0.9962213,0.0003110364,0.0000269617,0.002776875],"study_design_scores_gemma":[0.000002443795,0.00005933391,0.0004238867,0.000004393143,0.00001906014,0.00005123847,0.00001432606,0.000890454,0.9964594,0.000090104,0.001981524,0.000003897249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677755,0.002073036,0.0241853,0.0002843218,0.0001069734,0.0000492584,0.000399787,0.0001240413,0.005001793],"genre_scores_gemma":[0.9825283,0.002414038,0.01121257,0.00004489222,0.00001273475,0.00002022042,0.0005012265,0.00003835472,0.003227501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007372954,"threshold_uncertainty_score":0.002389908,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2130179418","doi":"10.1016/j.ymben.2010.07.001","title":"Network-based function prediction and interactomics: The case for metabolic enzymes","year":2010,"lang":"en","type":"review","venue":"Metabolic Engineering","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Wilfrid Laurier University","funders":"Medical Research Council; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Cambridge Trust; Cambridge Commonwealth Trust","keywords":"Computational biology; Protein function prediction; Inference; Function (biology); Computer science; Context (archaeology); Protein superfamily; Biology; Protein function; Artificial intelligence; Genetics; Gene","authors":[{"name":"Sarath Chandra Janga","is_ca":false},{"name":"J. Javier Díaz-Mejía","is_ca":true},{"name":"Gabriel Moreno‐Hagelsieb","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0120554485764473,"gpt":0.239384684273404,"spread":0.2273292356969567,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001982379,0.00234453,0.003337101,0.003070815,0.0002790015,0.002100502,0.002918463,0.001843283,0.001825773],"category_scores_gemma":[0.003039635,0.0007166301,0.0009963257,0.005195629,0.001288241,0.003140233,0.001174857,0.003063166,0.001908799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001208136,"about_ca_system_score_gemma":0.00106803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002016253,"about_ca_topic_score_gemma":0.002364425,"domain_scores_codex":[0.9993678,0.0001167063,0.00004153646,0.0001713233,0.0002704225,0.00003224963],"domain_scores_gemma":[0.9977297,0.001512304,0.0001632422,0.0001242666,0.0003975078,0.00007306398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001063615,0.0001003939,0.0006460309,0.007108978,0.000375188,0.0001946934,0.0000531804,0.005757009,0.004564404,0.01548189,0.02370839,0.9419034],"study_design_scores_gemma":[0.00007447331,0.0001326047,0.002687209,0.00505273,0.0005261241,0.002838045,0.0001249043,0.02460944,0.006566746,0.09443349,0.8627629,0.0001912645],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007376655,0.9616781,0.03349553,0.001169237,0.000401848,0.00002104097,0.0002527992,0.0002109111,0.002032728],"genre_scores_gemma":[0.005027507,0.9659946,0.02601212,0.0005568013,0.0005882122,0.00003625697,0.0005436754,0.00003894196,0.001201886],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003337101,"threshold_uncertainty_score":0.01048392,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2499340597","doi":"10.1016/j.ymben.2016.08.003","title":"Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines","year":2016,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Center for Complementary and Integrative Health; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Theobromine; Caffeine; Theophylline; Xanthine; Biosynthesis; Biochemistry; Purine; Metabolic engineering; Yeast; Chemistry; Flux (metallurgy); Purine metabolism; Saccharomyces cerevisiae; Enzyme; Biology; Pharmacology","authors":[{"name":"Maureen McKeague","is_ca":false},{"name":"Yen‐Hsiang Wang","is_ca":false},{"name":"Aaron Cravens","is_ca":false},{"name":"Maung Nyan Win","is_ca":false},{"name":"Christina D. Smolke","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.008121296677180466,"gpt":0.2092054236954954,"spread":0.2010841270183149,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992287,0.0005506675,0.0003058501,0.0002681004,0.0002613672,0.0005781744,0.0003890594,0.000389493,0.0005380987],"category_scores_gemma":[0.0002248126,0.0002310372,0.000343739,0.0002652728,0.000124479,0.0005462728,0.0008272302,0.0006981891,0.0003868052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934895,"about_ca_system_score_gemma":0.0002924248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003555679,"about_ca_topic_score_gemma":0.0009405902,"domain_scores_codex":[0.999861,0.00001707418,0.000009491301,0.00002484942,0.0000479219,0.00003965367],"domain_scores_gemma":[0.9999323,0.00001031956,0.00001494732,0.00001012272,0.0000102057,0.00002216785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004408895,0.00003661043,0.000121165,0.00004575169,0.000008113185,0.00007827486,0.00001688864,0.0005711862,0.994893,0.0004671261,0.00003581013,0.003682071],"study_design_scores_gemma":[0.00001365312,0.000223899,0.000407721,0.000008699765,0.00001716648,0.00009799359,0.00002736465,0.002707931,0.9933708,0.0002780403,0.002836905,0.000009819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741401,0.001471813,0.02086785,0.0001964888,0.00008490977,0.00008339598,0.0002823414,0.0002278712,0.002645176],"genre_scores_gemma":[0.9681741,0.001500595,0.02758638,0.00002609097,0.00001114507,0.00004978179,0.0003780182,0.00004473831,0.002229014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005781744,"threshold_uncertainty_score":0.002129436,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2127280148","doi":"10.1016/j.ymben.2010.08.004","title":"A functional analysis of N-glycosylation-related genes on sialylation of recombinant erythropoietin in six commonly used mammalian cell lines","year":2010,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Biomedical Research Council; World Anti-Doping Agency","keywords":"Recombinant DNA; Glycosylation; HEK 293 cells; Glycoprotein; Erythropoietin; Chinese hamster ovary cell; Cell culture; Gene; Molecular biology; Biology; Cell; Chemistry; Cell biology; Biochemistry; Genetics","authors":[{"name":"Peiqing Zhang","is_ca":false},{"name":"Diana Lifen Tan","is_ca":false},{"name":"Desmond Heng","is_ca":false},{"name":"Tianhua Wang","is_ca":false},{"name":"Mariati","is_ca":false},{"name":"Yuansheng Yang","is_ca":false},{"name":"Zhiwei Song","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0097655036058892,"gpt":0.2435164714839101,"spread":0.2337509678780209,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002659058,0.000380777,0.0002704794,0.000278771,0.000147671,0.0002480299,0.0002506449,0.0002167087,0.0005972554],"category_scores_gemma":[0.0002270743,0.0001426979,0.0003983942,0.000288415,0.0002425333,0.0002013842,0.0001876796,0.0004606624,0.000275584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002399183,"about_ca_system_score_gemma":0.0002096079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008484279,"about_ca_topic_score_gemma":0.0005961825,"domain_scores_codex":[0.999819,0.00003886871,0.00002793208,0.00003076704,0.00005635889,0.0000271368],"domain_scores_gemma":[0.9997949,0.00007111437,0.00003123366,0.00004076137,0.0000345527,0.00002747734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004817958,0.000006165963,0.00008998685,0.000009120196,0.000002504008,0.00001733488,0.00001176331,0.00001962067,0.999416,0.00005787977,0.000004328923,0.0003172852],"study_design_scores_gemma":[0.000003534922,0.00006883014,0.001885349,0.000001616483,0.00001790328,0.00008249099,0.00001548098,0.0002034305,0.996992,0.00001859037,0.0007085697,0.000002184988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915158,0.000519279,0.005962456,0.00003841912,0.00001751545,0.00004022612,0.00069302,0.00004862809,0.001164694],"genre_scores_gemma":[0.9861456,0.0007113389,0.005850918,0.00003509108,0.000007827862,0.00005453049,0.00333735,0.00005815324,0.003799155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008484279,"threshold_uncertainty_score":0.001998067,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3128129901","doi":"10.1016/j.ymben.2021.01.011","title":"The yeast platform engineered for synthetic gRNA-landing pads enables multiple gene integrations by a single gRNA/Cas9 system","year":2021,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Plant tissue culture and regeneration","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; National Research Foundation of Korea","keywords":"CRISPR; Biology; Cas9; Multiplex; Guide RNA; Gene; Computational biology; Genome editing; Saccharomyces cerevisiae; Synthetic biology; Yeast; Genetics; Green fluorescent protein","authors":[{"name":"Sihyun Baek","is_ca":true},{"name":"Joseph Christian Utomo","is_ca":true},{"name":"Ji Young Lee","is_ca":false},{"name":"Kunal Dalal","is_ca":true},{"name":"Yeo Joon Yoon","is_ca":false},{"name":"Dae‐Kyun Ro","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01025682215603674,"gpt":0.1953641028215373,"spread":0.1851072806655006,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000306844,0.001176463,0.0006519436,0.0007240822,0.0004705583,0.0007797104,0.001053608,0.0006985868,0.003656855],"category_scores_gemma":[0.0002920333,0.0006190396,0.0006168252,0.0004198812,0.0003560275,0.0004712157,0.001191016,0.001682431,0.004604877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002990037,"about_ca_system_score_gemma":0.0005169486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000704506,"about_ca_topic_score_gemma":0.001358679,"domain_scores_codex":[0.9996911,0.00002190115,0.00003635408,0.00009206071,0.000111785,0.00004679897],"domain_scores_gemma":[0.9997413,0.00003601014,0.0000533986,0.00006882328,0.00002994984,0.00007061755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009206097,0.00002722734,0.0001213822,0.00006055636,0.00001108259,0.00009483974,0.00002324146,0.0001353097,0.9927508,0.0008067,0.0002939861,0.005582777],"study_design_scores_gemma":[0.00001527615,0.00006271356,0.0004415157,0.000006838978,0.00001896657,0.0003148978,0.00001394405,0.0008862288,0.9871058,0.0001546235,0.01095965,0.00001946186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4030099,0.0009787556,0.5631312,0.0004313434,0.0004807044,0.0004887239,0.005190501,0.01885996,0.007428912],"genre_scores_gemma":[0.6311047,0.001142237,0.3312617,0.0001792493,0.00004389673,0.0004655466,0.01056378,0.004050889,0.02118796],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003656855,"threshold_uncertainty_score":0.01223344,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2125546186","doi":"10.1016/j.ymben.2005.06.002","title":"Chemostat culture characterization of Escherichia coli mutant strains metabolically engineered for aerobic succinate production: A study of the modified metabolic network based on metabolite profile, enzyme activity, and gene expression profile","year":2005,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Andlinger Center for Energy and the Environment, Princeton University; Canadian Association for the Study of the Liver; National Science Foundation","keywords":"Malate synthase; Mutant; Escherichia coli; Biochemistry; Chemostat; Isocitrate lyase; Malate dehydrogenase; Strain (injury); Enzyme; Succinate dehydrogenase; Biology; Gene; Molecular biology; Chemistry; Glyoxylate cycle; Bacteria; Genetics","authors":[{"name":"Henry Lin","is_ca":false},{"name":"George N. Bennett","is_ca":false},{"name":"Ka‐Yiu San","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.007542032199349087,"gpt":0.2118921660156475,"spread":0.2043501338162984,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232463,0.0003828218,0.0002896379,0.000275043,0.000132282,0.0002454074,0.0002237592,0.0001743276,0.00058207],"category_scores_gemma":[0.000219797,0.0001708003,0.0002145886,0.0003942098,0.0001295658,0.0001864356,0.0001768372,0.0003307097,0.0002470489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002855449,"about_ca_system_score_gemma":0.000386855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004788325,"about_ca_topic_score_gemma":0.005006038,"domain_scores_codex":[0.9998341,0.00001389813,0.00002822736,0.00003747461,0.00006062934,0.00002556594],"domain_scores_gemma":[0.9998131,0.00003956598,0.00003949397,0.00002275687,0.00005267393,0.00003246289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007020035,0.00002404291,0.0006032698,0.000007983053,0.000002619926,0.0000182621,0.000009158318,0.00003921419,0.998665,0.00001888456,0.00001765394,0.0005236218],"study_design_scores_gemma":[0.000004482175,0.0001172408,0.01256256,0.000002003188,0.00001442592,0.00007953486,0.00002678968,0.0008400087,0.9860043,0.00001483888,0.0003296254,0.000004263132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927818,0.0003032383,0.003491235,0.00008906572,0.00002386307,0.00004193155,0.00209156,0.00006035483,0.001116984],"genre_scores_gemma":[0.9876916,0.0003892685,0.005551138,0.00004675349,0.00000722599,0.00005880757,0.003379039,0.0000604704,0.002815804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004788325,"threshold_uncertainty_score":0.009520948,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2898655184","doi":"10.1016/j.ymben.2018.10.008","title":"Increased sesqui- and triterpene production by co-expression of HMG-CoA reductase and biotin carboxyl carrier protein in tobacco (Nicotiana benthamiana)","year":2018,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Rural Development Administration; Ministry of Education; Neurosciences Research Foundation","keywords":"Nicotiana benthamiana; Triterpene; Biochemistry; Biotin; Chemistry; HMG-CoA reductase; Reductase; Biology; Enzyme; Medicine","authors":[{"name":"Ahreum Lee","is_ca":false},{"name":"Moonhyuk Kwon","is_ca":true},{"name":"Min‐Kyoung Kang","is_ca":false},{"name":"Jeong‐Han Kim","is_ca":false},{"name":"Soo-Un Kim","is_ca":false},{"name":"Dae‐Kyun Ro","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.003979323222549182,"gpt":0.2028453949380044,"spread":0.1988660717154552,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001932841,0.0006488289,0.0004007133,0.0003182173,0.000248173,0.0006249189,0.0004448854,0.0004002677,0.001272667],"category_scores_gemma":[0.0001141192,0.0002971695,0.0005235653,0.0003733213,0.0002368933,0.0004141142,0.0004028313,0.0007343069,0.0005896127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000681654,"about_ca_system_score_gemma":0.0003421158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002206304,"about_ca_topic_score_gemma":0.003561108,"domain_scores_codex":[0.9998081,0.00002269651,0.00002308785,0.00004882853,0.00005042985,0.00004677968],"domain_scores_gemma":[0.9998392,0.0000218238,0.00003476273,0.00002385892,0.00002422058,0.00005608733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002569324,0.000008322345,0.0000298506,0.000007404044,0.000002438816,0.00001104916,0.000005556352,0.00001743822,0.999655,0.00004159788,0.000004856321,0.000190755],"study_design_scores_gemma":[0.000005636305,0.00003363389,0.0009896032,0.00000169359,0.00001846399,0.00005091882,0.00001456574,0.0004840096,0.9976442,0.00002166172,0.0007321229,0.000003526403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907529,0.0009816261,0.005279436,0.0001797392,0.00005611163,0.00003135153,0.0005671523,0.0002686119,0.00188309],"genre_scores_gemma":[0.9891896,0.0004138165,0.002954074,0.00004430101,0.00000824339,0.0000179806,0.0009628988,0.0001017978,0.006307268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206304,"threshold_uncertainty_score":0.004945755,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3055099206","doi":"10.1016/j.ymben.2020.08.006","title":"Novel two-stage processes for optimal chemical production in microbes","year":2020,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Ontario Ministry of Research, Innovation and Science; Genome Canada","keywords":"Bioprocess; Biochemical engineering; Metabolic engineering; Production (economics); Organism; Microbial metabolism; Yield (engineering); Phenotype; Biology; Biological system; Computer science; Biochemistry; Bacteria; Genetics; Engineering; Materials science","authors":[{"name":"Kaushik Raj","is_ca":true},{"name":"Naveen Venayak","is_ca":true},{"name":"Radhakrishnan Mahadevan","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01200264417251522,"gpt":0.2263483906689267,"spread":0.2143457464964115,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003563214,0.0006992359,0.0006855289,0.000304453,0.0003907227,0.001219876,0.0009791445,0.0008376841,0.001114854],"category_scores_gemma":[0.0003175403,0.0004266294,0.0005013716,0.00035082,0.0003248116,0.001603668,0.001017328,0.001269364,0.0006405764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005382133,"about_ca_system_score_gemma":0.00051713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003085742,"about_ca_topic_score_gemma":0.0006969436,"domain_scores_codex":[0.9997112,0.00004200169,0.0000202476,0.00006627914,0.0001035878,0.00005670199],"domain_scores_gemma":[0.9998949,0.00002846462,0.00001716468,0.00001615804,0.0000225167,0.00002082439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685537,0.0001733741,0.0001230001,0.0001935577,0.00001132269,0.00006824164,0.00003613911,0.001286258,0.9768419,0.004376536,0.0001944565,0.01652682],"study_design_scores_gemma":[0.00006363279,0.0003832881,0.0003075196,0.00001184642,0.00001835386,0.0001306406,0.00002047999,0.0200424,0.9721841,0.001407261,0.005392404,0.00003815814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6476048,0.008447614,0.3319712,0.001074319,0.0005898783,0.0004130008,0.0005092571,0.001172781,0.008217168],"genre_scores_gemma":[0.7940065,0.003398856,0.1939089,0.0001443609,0.00008449462,0.0003003369,0.0003659594,0.00013794,0.007652565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001219876,"threshold_uncertainty_score":0.003905058,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4362475377","doi":"10.1016/j.ymben.2023.03.010","title":"Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)","year":2023,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Chromatography in Natural Products","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Concordia University","funders":"","keywords":"Benzylisoquinoline; Lotus; Opium Poppy; Biosynthesis; Papaver; Stereochemistry; Lotus japonicus; Alkaloid; Metabolic pathway; Biology; Chemistry; Botany; Biochemistry; Metabolism; Enzyme","authors":[{"name":"Michael E. Pyne","is_ca":true},{"name":"Nicholas D. Gold","is_ca":true},{"name":"Vincent J. J. Martin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006740756959575503,"gpt":0.1908770535043602,"spread":0.1841362965447847,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006124406,0.0002555806,0.0001132745,0.0002250899,0.0001577827,0.0002051931,0.0001264312,0.000134194,0.0005704489],"category_scores_gemma":[0.00007306424,0.00007462337,0.0002050173,0.0002033455,0.0001168163,0.0002779318,0.0001775585,0.0003627605,0.0002868051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002430462,"about_ca_system_score_gemma":0.0004367747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001523379,"about_ca_topic_score_gemma":0.004088179,"domain_scores_codex":[0.9999622,0.000004231132,0.00000314211,0.000009459359,0.000009242665,0.00001174682],"domain_scores_gemma":[0.9999583,0.000006714281,0.00001032272,0.000003876729,0.000009923567,0.00001090865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006517147,0.0000405249,0.0003174449,0.00009737322,0.00000520961,0.0001568218,0.00006169947,0.0002846869,0.9918283,0.0002375692,0.00005138926,0.006853849],"study_design_scores_gemma":[0.00001751033,0.0004366372,0.005616358,0.00002703888,0.00004283767,0.0003353479,0.0002114722,0.001685307,0.9821946,0.0002493942,0.009167823,0.00001562986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838847,0.001356832,0.007938311,0.0001677962,0.00002669373,0.00007348378,0.0007720021,0.00005943088,0.005720763],"genre_scores_gemma":[0.9870368,0.001006667,0.007708875,0.00003401245,0.00000344571,0.00002379362,0.0007468082,0.00002045461,0.003419022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523379,"threshold_uncertainty_score":0.003028989,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2563671662","doi":"10.1016/j.ymben.2016.12.001","title":"Improvement of 1,3-propanediol production using an engineered cyanobacterium, Synechococcus elongatus by optimization of the gene expression level of a synthetic metabolic pathway and production conditions","year":2016,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Japan Science and Technology Agency; Petroleum Technology Research Centre","keywords":"Glycerol; 1,3-Propanediol; Metabolic engineering; Metabolic pathway; Saccharomyces cerevisiae; Biochemistry; Escherichia coli; Cyanobacteria; Chemistry; Metabolite; Gene; Biology; Bacteria; Genetics","authors":[{"name":"Yasutaka Hirokawa","is_ca":false},{"name":"Yuki Maki","is_ca":false},{"name":"Taizo Hanai","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01421291240846306,"gpt":0.2122395889992149,"spread":0.1980266765907518,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000368204,0.0008330846,0.0003794073,0.0002850439,0.0002438035,0.0006262917,0.0003732044,0.0003555803,0.0003119001],"category_scores_gemma":[0.0003862157,0.0002395482,0.0002875422,0.0004190954,0.0002150204,0.0004220675,0.0004707232,0.0005491823,0.0002127879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008815544,"about_ca_system_score_gemma":0.0007845523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003422831,"about_ca_topic_score_gemma":0.00493716,"domain_scores_codex":[0.9996612,0.00004343276,0.00005026161,0.00006699729,0.0001309275,0.00004713754],"domain_scores_gemma":[0.9998049,0.00004154163,0.00004940639,0.0000226442,0.00004072198,0.00004064489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003463028,0.00002364325,0.0001188,0.00001734756,0.000002792512,0.00002520712,0.000006575488,0.0002043151,0.9989616,0.00002210828,0.0000058297,0.0005771334],"study_design_scores_gemma":[0.000005404956,0.00003814555,0.000533706,0.000002150181,0.000008635629,0.00003028378,0.000011891,0.0006642822,0.9984377,0.0000112218,0.0002526667,0.000003849402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912025,0.0003849199,0.006780208,0.0001658511,0.00002714183,0.00004050895,0.000321478,0.00009545298,0.000981866],"genre_scores_gemma":[0.98772,0.0005652375,0.009496268,0.00004280787,0.000005530213,0.00003653201,0.0006885213,0.00006474141,0.001380428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003422831,"threshold_uncertainty_score":0.006805778,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4382518227","doi":"10.1016/j.ymben.2023.06.012","title":"Engineering Escherichia coli to produce aromatic chemicals from ethylene glycol","year":2023,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Education - Singapore; National Research Foundation Singapore","keywords":"Escherichia coli; Glycerol; Fermentation; Chemistry; Ethylene glycol; Aromatic amino acids; Hydrolysis; Metabolic engineering; Cellulosic ethanol; Raw material; Organic chemistry; Phenylalanine; Biochemistry; Sugar; Substrate (aquarium); Cellulose; Biology; Enzyme; Amino acid","authors":[{"name":"Smaranika Panda","is_ca":false},{"name":"Jie Zhou","is_ca":false},{"name":"Michelle Feigis","is_ca":true},{"name":"Emma Harrison","is_ca":true},{"name":"Xiaoqiang Ma","is_ca":true},{"name":"Vincent Fung Kin Yuen","is_ca":false},{"name":"Radhakrishnan Mahadevan","is_ca":true},{"name":"Kang Zhou","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.006566745269307934,"gpt":0.2122277190133879,"spread":0.20566097374408,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509836,0.0005229281,0.0001982793,0.0003213361,0.0001445439,0.0003858405,0.0002265251,0.0003223864,0.0004764441],"category_scores_gemma":[0.0002068981,0.0001701361,0.0002499417,0.0004509644,0.0001459139,0.0001783752,0.0002832226,0.0005915589,0.0003732049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245772,"about_ca_system_score_gemma":0.0003880293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002028984,"about_ca_topic_score_gemma":0.003067762,"domain_scores_codex":[0.9998407,0.00002045592,0.00001287541,0.00001803143,0.00006067648,0.00004725796],"domain_scores_gemma":[0.9999281,0.00001923334,0.00001634233,0.000007073946,0.00001502289,0.00001423726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008670989,0.0001318656,0.0004732712,0.00003460286,0.000007359131,0.00009000474,0.00001581988,0.0003531411,0.9930737,0.0003607741,0.00005045011,0.005322266],"study_design_scores_gemma":[0.00001036132,0.0001145493,0.0007438348,0.000003483227,0.00001171177,0.00007853532,0.00002258269,0.0009440656,0.9959109,0.00004582362,0.002110373,0.00000379695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677554,0.0005774279,0.02637278,0.0003254099,0.00009092199,0.0001343353,0.0004681457,0.0002158741,0.004059669],"genre_scores_gemma":[0.9665936,0.0009804559,0.02314577,0.0001317865,0.00001023608,0.00004487911,0.000741237,0.0000503226,0.008301603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002028984,"threshold_uncertainty_score":0.0040344,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2079518233","doi":"10.1016/j.ymben.2013.01.007","title":"Adaptively evolved yeast mutants on galactose show trade-offs in carbon utilization on glucose","year":2013,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Fondation Chalmers; Novo Nordisk Fonden; Knut och Alice Wallenbergs Stiftelse","keywords":"Galactose; Yeast; Mutant; Saccharomyces cerevisiae; Biochemistry; Chemistry; Biology; Gene","authors":[{"name":"Kuk-Ki Hong","is_ca":false},{"name":"Jens Nielsen","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0134992015746683,"gpt":0.2123218516717003,"spread":0.198822650097032,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971908,0.0009543098,0.0006073409,0.0007209029,0.0002125823,0.001011931,0.000716301,0.0006700768,0.001415505],"category_scores_gemma":[0.000552047,0.0003714497,0.0004113897,0.0005926123,0.0006185969,0.0002757924,0.001073751,0.001184941,0.000272207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005146919,"about_ca_system_score_gemma":0.0002478458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006561574,"about_ca_topic_score_gemma":0.000625008,"domain_scores_codex":[0.9996701,0.00005219672,0.00003985581,0.00006910486,0.000107517,0.00006131233],"domain_scores_gemma":[0.9994543,0.000143287,0.0001232611,0.00008690499,0.0000579707,0.0001341838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000347816,0.00005427607,0.0009765766,0.0000148105,0.0000224423,0.00009454456,0.00002010884,0.0003231884,0.9964741,0.0001368421,0.00001942149,0.001515834],"study_design_scores_gemma":[0.00004444976,0.0004565963,0.01827368,0.00001118008,0.0000562569,0.0007086479,0.0001525399,0.004491749,0.9749269,0.0002294271,0.0006001869,0.00004831455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998502,0.0001045938,0.0006723382,0.00005396992,0.00001252306,0.000004502504,0.0001131514,0.00005374404,0.0004832975],"genre_scores_gemma":[0.997916,0.0001022612,0.00069611,0.00003837283,0.000005142877,0.000009776307,0.0001700065,0.00007617292,0.0009860091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001415505,"threshold_uncertainty_score":0.004735291,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3081130353","doi":"10.1016/j.ymben.2020.08.011","title":"Punicic acid production in Brassica napus","year":2020,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Alberta Innovates; Alberta Agriculture and Forestry","keywords":"Canola; Brassica; Conjugated linoleic acid; Oleic acid; Linolenic acid; Fatty acid; Food science; Biology; Biochemistry; Linoleic acid; Botany","authors":[{"name":"Yang Xu","is_ca":true},{"name":"Elzbieta Mietkiewska","is_ca":true},{"name":"Saleh Shah","is_ca":true},{"name":"Randall J. Weselake","is_ca":true},{"name":"Guanqun Chen","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.00852731305236223,"gpt":0.1966044287872226,"spread":0.1880771157348604,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680227,0.0007047709,0.0003048405,0.0005461281,0.0003847145,0.0004119834,0.0003608585,0.0002997255,0.0005571712],"category_scores_gemma":[0.0001754499,0.0002539035,0.0002977713,0.0004809093,0.0001709603,0.0002376468,0.0003492508,0.0007160113,0.0003708054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007456413,"about_ca_system_score_gemma":0.0004269211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004956974,"about_ca_topic_score_gemma":0.006005927,"domain_scores_codex":[0.9998518,0.00003286565,0.00001514765,0.00003018768,0.0000429317,0.00002701834],"domain_scores_gemma":[0.9998459,0.00002866092,0.00002541533,0.00001981274,0.00002247623,0.00005767924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005865274,0.00001401496,0.0000546194,0.00001812256,0.000001760948,0.00003584591,0.000008397087,0.0001049478,0.9989147,0.00003116096,0.00001152369,0.0007461228],"study_design_scores_gemma":[0.00002503836,0.0001952285,0.003364295,0.000008043459,0.00002401382,0.0001353294,0.00004703,0.0008796032,0.9920427,0.00005809164,0.003211394,0.000009220607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899616,0.001916477,0.002777381,0.0002874841,0.00005590258,0.00004000817,0.0006769554,0.0002514433,0.004032742],"genre_scores_gemma":[0.9864245,0.001182422,0.003159937,0.0001047733,0.0000141973,0.00003388594,0.001456952,0.00007653512,0.007546916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004956974,"threshold_uncertainty_score":0.009856224,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}