{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":119,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":119,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"query_hash":"edfaa69890df","filters":{"venue":"Molecular Therapy — Methods & Clinical Development"}},"results":[{"id":"W3026328714","doi":"10.1016/j.omtm.2020.05.013","title":"Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":339,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"College of Medicine, King Saud University; King Saud University; University of Sharjah","keywords":"TMPRSS2; COPD; Receptor; Coronavirus disease 2019 (COVID-19); Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Internal medicine; Virology; Disease","retraction":null,"screen_n_in":null,"score":{"opus":0.08916866111858206,"gpt":0.4637977240586176,"spread":0.3746290629400355,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002698236,0.0003147646,0.001000557,0.00009991453,0.00007755245,0.00002296977,0.0001376995,0.0002096557,0.00002335014],"category_scores_gemma":[0.007620521,0.0002226773,0.00008947276,0.0002869789,0.0004758505,0.00005793201,0.000443888,0.0005503958,0.000001202701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003442949,"about_ca_system_score_gemma":0.000244666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007456067,"about_ca_topic_score_gemma":0.000005147424,"domain_scores_codex":[0.9964982,0.0008806358,0.0008839397,0.0008633704,0.0005248759,0.0003489645],"domain_scores_gemma":[0.9957621,0.003250956,0.000212307,0.0002955959,0.0001449021,0.0003341723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005266492,0.0004537634,0.5896477,0.0002605286,0.000398103,0.00004235909,0.001459301,4.909612e-7,0.05636376,0.00000787759,0.0000894565,0.3460102],"study_design_scores_gemma":[0.01106839,0.002708241,0.7018343,0.001341767,0.00006487108,0.000004478562,0.0001093214,0.00009248154,0.2746775,0.0001101656,0.007590251,0.0003982279],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850388,0.003512809,0.007094609,0.003349076,0.00002542872,0.000917876,0.000006257654,0.00003174424,0.0000234521],"genre_scores_gemma":[0.7904337,0.01018286,0.1921713,0.007068863,0.00003575912,0.0000505883,0.000008163854,0.00003905603,0.000009726096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.345612,"threshold_uncertainty_score":0.9123027,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2900871300","doi":"10.1016/j.omtm.2018.11.003","title":"Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":158,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canadian Nuclear Laboratories","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Fondation Bertarelli; Harvard Medical School; National Institute on Deafness and Other Communication Disorders; National Eye Institute; Howard Hughes Medical Institute","keywords":"Transduction (biophysics); Transgene; Hair cell; Inner ear; Biology; Genetic enhancement; Cochlea; Viral vector; Gene; Translation (biology); Gene delivery; Green fluorescent protein; Cell biology; Capsid; Vector (molecular biology); Genetics; Messenger RNA; Neuroscience; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.1299963305844325,"gpt":0.434897692451616,"spread":0.3049013618671835,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004336535,0.0004026041,0.0008491435,0.0003024705,0.0001006731,0.00005654073,0.0004619763,0.0002515785,0.00001784803],"category_scores_gemma":[0.0001539693,0.0003519973,0.0001061679,0.0004892081,0.0005022585,0.0001001645,0.0001084711,0.0005086376,0.000005194686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007046318,"about_ca_system_score_gemma":0.0002854802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005973825,"about_ca_topic_score_gemma":0.00009197386,"domain_scores_codex":[0.9948287,0.001485497,0.001453181,0.001072034,0.0005024586,0.000658131],"domain_scores_gemma":[0.9986523,0.0003740697,0.0001179504,0.0005597659,0.00007854086,0.0002173728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003251086,0.0004189542,0.001933491,0.00004962327,0.00003171295,0.00006639233,0.003648405,0.0004594166,0.9619578,0.00002837839,5.556055e-7,0.03108022],"study_design_scores_gemma":[0.002419207,0.0005956905,0.01581514,0.0001389207,0.000009579134,0.00001175805,0.00003092098,0.003353793,0.9767587,0.0003073738,0.0001238635,0.0004350522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8293318,0.0000844403,0.1695738,0.00008374271,0.00005637883,0.0007277897,0.000003700089,0.0000381041,0.0001002538],"genre_scores_gemma":[0.6474883,0.0002399875,0.3515024,0.0005614554,0.000008405991,0.00004826725,8.056629e-7,0.00006197101,0.00008837772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1819287,"threshold_uncertainty_score":0.9998932,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3003231717","doi":"10.1016/j.omtm.2020.01.012","title":"A High-Throughput Method for Characterizing Novel Chimeric Antigen Receptors in Jurkat Cells","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; McGill University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Jurkat cells; Chimeric antigen receptor; Antigen; Monoclonal antibody; Biology; Cell biology; Electroporation; Computational biology; T cell; Molecular biology; Chemistry; Antibody; Immunology; Immune system; Genetics; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.1650440630424239,"gpt":0.4849395707982245,"spread":0.3198955077558006,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007838077,0.0005604122,0.001658861,0.0002312976,0.0001170512,0.00006531484,0.0005032668,0.0004242649,0.0009689568],"category_scores_gemma":[0.0009848358,0.0005005102,0.0006068377,0.000995029,0.0001329323,0.00008418593,0.0002143855,0.000960396,0.00006821562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141257,"about_ca_system_score_gemma":0.0007211554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003586173,"about_ca_topic_score_gemma":0.000002041913,"domain_scores_codex":[0.9933966,0.001616045,0.001924713,0.001407276,0.0007013069,0.0009540034],"domain_scores_gemma":[0.9964883,0.001630985,0.0003405684,0.000658575,0.0002218517,0.0006597002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001496809,0.0003916716,0.00044484,0.00005218253,0.0003675078,0.00003106821,0.0007915749,0.000006010288,0.5484973,0.00004347845,0.00009415278,0.4477834],"study_design_scores_gemma":[0.005907205,0.0008147333,0.00472432,0.00007629197,0.00002962921,0.00000702005,0.00006473861,0.0005698362,0.6030089,0.0001039921,0.3842609,0.0004323761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.257904,0.0005721237,0.7311754,0.006636089,0.0007976787,0.00264004,0.000007967851,0.0001275629,0.0001390989],"genre_scores_gemma":[0.002207764,0.00147478,0.979542,0.01501986,0.0003587191,0.0003710245,0.00008671486,0.000187827,0.0007512865],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.447351,"threshold_uncertainty_score":0.9999443,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4387747059","doi":"10.1016/j.omtm.2023.101139","title":"Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Precision Nanosystems (Canada)","funders":"Bundesministerium für Bildung und Forschung","keywords":"Electroporation; Chimeric antigen receptor; In vitro; In vivo; Messenger RNA; Cell; Ex vivo; T cell; Cell biology; Chemistry; Biology; Immunology; Immune system; Biotechnology; Gene; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.09062217181834831,"gpt":0.4393684752559198,"spread":0.3487463034375715,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006504457,0.0003106011,0.0006389535,0.0004227856,0.00007057247,0.00004478957,0.0002305383,0.000248383,0.0004209144],"category_scores_gemma":[0.000500518,0.0002804343,0.0002481288,0.001232078,0.00006489697,0.00005091436,0.00006870283,0.0006703165,0.0001616965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002869547,"about_ca_system_score_gemma":0.000639143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001575788,"about_ca_topic_score_gemma":0.000005425445,"domain_scores_codex":[0.9961429,0.0007123398,0.001108828,0.0006277886,0.0006549913,0.0007532118],"domain_scores_gemma":[0.9983155,0.0005889283,0.0001108096,0.0005361187,0.0001416596,0.0003069412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003868153,0.0003076181,0.006587092,0.00004134348,0.00007942761,0.0001242773,0.0002120664,0.00035724,0.7241022,0.00001771221,0.00005841213,0.2677258],"study_design_scores_gemma":[0.003633819,0.0005657116,0.02683211,0.00004329243,0.00001403507,0.00000375358,0.00004458546,0.008316128,0.8966542,0.00005973334,0.06352914,0.0003034265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746601,0.0004497701,0.02225834,0.001015649,0.0002219083,0.000925763,7.975377e-7,0.0002265895,0.0002410571],"genre_scores_gemma":[0.6081017,0.0008420647,0.3870476,0.001756796,0.0001943127,0.0003469462,0.0001335749,0.0001668622,0.001410032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3665584,"threshold_uncertainty_score":0.9999648,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2313586256","doi":"10.1038/mtm.2016.18","title":"Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses","year":2016,"lang":"en","type":"review","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Oncolytics Biotech (Canada); Ottawa Hospital","funders":"","keywords":"Oncolytic virus; Computational biology; Biology; Virus; Biotechnology; Virology","retraction":null,"screen_n_in":null,"score":{"opus":0.2024582552555836,"gpt":0.5138634088228434,"spread":0.3114051535672598,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01493535,0.0008741159,0.002310044,0.0002421441,0.0003565735,0.00009440223,0.001334947,0.001089154,0.00009047044],"category_scores_gemma":[0.003059995,0.0005735223,0.001024286,0.0005632794,0.001056641,0.00002207035,0.0006058359,0.0008337572,0.00008729073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268979,"about_ca_system_score_gemma":0.002337382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000698556,"about_ca_topic_score_gemma":0.00001438633,"domain_scores_codex":[0.9839685,0.008688632,0.004163253,0.00188823,0.0006799158,0.0006114667],"domain_scores_gemma":[0.993494,0.001369446,0.002166142,0.002062732,0.0005662469,0.0003414001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006261769,0.0004653637,0.0002312689,0.0005867235,0.001441492,0.000004729999,0.0001166701,2.81381e-7,0.0309904,0.00001296307,0.00007183053,0.9654521],"study_design_scores_gemma":[0.001013082,0.001474434,0.000457851,0.001490923,0.0002819642,0.000008318796,0.00002679467,0.000001573801,0.04786993,0.0001476388,0.946499,0.000728522],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05936097,0.9210541,0.01402124,0.0003393966,0.001374166,0.003725912,0.00003049346,0.00005692502,0.00003680755],"genre_scores_gemma":[0.0001142472,0.9668679,0.02970215,0.001167775,0.0006929607,0.0005714098,0.0001573553,0.0001921269,0.0005340697],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9647236,"threshold_uncertainty_score":0.9996716,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2345080518","doi":"10.1038/mtm.2016.30","title":"Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens","year":2016,"lang":"en","type":"review","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Government of the United Kingdom; Government of Ontario; McMaster University","keywords":"Virology; Viral vector; Vaccination; Immunization; Vector (molecular biology); Tuberculosis vaccines; Vaccinia; Biology; Mycobacterium tuberculosis; Immunology; Medicine; Immune system; Tuberculosis; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.1530327904689581,"gpt":0.5347538919907486,"spread":0.3817211015217905,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0239423,0.001566194,0.004599734,0.0004245368,0.0002643589,0.00007805922,0.001704487,0.002173274,0.0001131738],"category_scores_gemma":[0.002310588,0.001157374,0.00191324,0.0005608576,0.0005849893,0.00001131872,0.001278747,0.001169642,0.00006188526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014298,"about_ca_system_score_gemma":0.004425096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001461659,"about_ca_topic_score_gemma":0.00001284017,"domain_scores_codex":[0.9746436,0.01460506,0.006018363,0.002696692,0.0008062935,0.001229966],"domain_scores_gemma":[0.9927402,0.001970605,0.001821642,0.002080679,0.0005421992,0.0008446671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001010473,0.0005283391,0.00007838017,0.0008925964,0.003792155,0.00003101516,0.00005732093,2.230558e-7,0.02194711,0.000007965545,0.00008299683,0.9715714],"study_design_scores_gemma":[0.002309842,0.001636092,0.0002515983,0.001616208,0.0002413829,0.00001825872,0.00001150568,0.000002363548,0.05632332,0.00006496984,0.9361044,0.00142002],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009737382,0.8939942,0.09307142,0.00004716171,0.0008925851,0.00202977,0.00004553594,0.00005801893,0.0001239246],"genre_scores_gemma":[0.00001013694,0.5630296,0.4354955,0.0002940415,0.0002777484,0.0002513011,0.0002116101,0.0002162884,0.0002138016],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9701514,"threshold_uncertainty_score":0.9997087,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4380373552","doi":"10.1016/j.omtm.2023.06.005","title":"Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"iCo Therapeutics (Canada); University of British Columbia","funders":"Networks of Centres of Excellence of Canada; NanoMedicines Innovation Network; Canadian Institutes of Health Research; University of Pune; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Sphingomyelin; Messenger RNA; Protein expression; Chemistry; Cell biology; Internal medicine; Endocrinology; Biology; Biochemistry; Cholesterol; Gene; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.09510745692056474,"gpt":0.3974518432250009,"spread":0.3023443863044362,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002831422,0.0002684191,0.000528045,0.0001074312,0.00006022838,0.00003518268,0.0002501926,0.0002607127,0.00003059014],"category_scores_gemma":[0.0002745498,0.0002329727,0.0001007887,0.0002177635,0.00009546572,0.00001021083,0.000185896,0.0001793117,0.00001359514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002088555,"about_ca_system_score_gemma":0.0001268416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003731792,"about_ca_topic_score_gemma":0.000007142471,"domain_scores_codex":[0.996469,0.001208482,0.001085375,0.0006084052,0.0002467881,0.0003819441],"domain_scores_gemma":[0.998961,0.0001591519,0.0002407839,0.0003999785,0.0001094644,0.0001295896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002127347,0.0001010732,0.003883095,0.00005404286,0.0001100844,0.00002211362,0.0003269094,0.00006221802,0.9173294,0.00003466663,0.00001883921,0.07784482],"study_design_scores_gemma":[0.001273284,0.0005613074,0.02813758,0.0002401119,0.00001053135,0.000002136041,0.0001381402,0.0002309527,0.9647996,0.000221575,0.004074567,0.0003102332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838443,0.002773195,0.01230167,0.00009761546,0.0003262449,0.0005920462,0.000004282184,0.00002818064,0.00003246986],"genre_scores_gemma":[0.9443372,0.0006074205,0.05425261,0.0001809264,0.00007646672,0.0001731196,0.00002361458,0.00004000078,0.0003086711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07753459,"threshold_uncertainty_score":0.950035,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2797362195","doi":"10.1016/j.omtm.2018.04.005","title":"A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba; Public Health Agency of Canada; University of Guelph","funders":"National Heart, Lung, and Blood Institute; Lung Health Foundation; Cystic Fibrosis Canada","keywords":"Transgene; Mutant; Respiratory tract; Capsid; Respiratory system; Genetically modified mouse; Biology; Cell biology; Molecular biology; Immunology; Anatomy; Gene; Genetics; Virus","retraction":null,"screen_n_in":null,"score":{"opus":0.1156586279432417,"gpt":0.4403063420627287,"spread":0.324647714119487,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007113583,0.0002865449,0.0004219527,0.0001122107,0.0001216985,0.00003164021,0.0004239022,0.0003070431,0.00001942479],"category_scores_gemma":[0.0002735954,0.0002053989,0.0001273338,0.0002274835,0.0004395513,0.000007678868,0.0001169536,0.0003144639,0.000001214348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001608994,"about_ca_system_score_gemma":0.0002842385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001055295,"about_ca_topic_score_gemma":0.00002880767,"domain_scores_codex":[0.995613,0.002055208,0.0008783703,0.0007050874,0.000365406,0.000382917],"domain_scores_gemma":[0.9987712,0.0002320311,0.0001910249,0.0005239588,0.0001310793,0.0001507351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00124276,0.000345907,0.0002300635,0.00001119704,0.000063857,0.00000538868,0.0005123517,0.000001073837,0.7214383,0.000003264547,0.000009512564,0.2761362],"study_design_scores_gemma":[0.003059974,0.003067722,0.02836329,0.00003836439,0.00001060611,0.000009160871,0.0001610203,0.00001132596,0.9535842,0.0001072776,0.01133173,0.0002553408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745551,0.007649058,0.01662831,0.000326721,0.0001077267,0.0006604443,0.000006850017,0.000007479215,0.0000583121],"genre_scores_gemma":[0.9101146,0.001894813,0.08560833,0.002121918,0.0001028838,0.00008914764,0.00001234744,0.00004272266,0.00001317736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2758809,"threshold_uncertainty_score":0.8375925,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3107924035","doi":"10.1016/j.omtm.2020.11.014","title":"CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Gilead Sciences","keywords":"cccDNA; Virology; Hepatitis B virus; Cas9; Entecavir; Biology; Adeno-associated virus; Genetic enhancement; Virus; Genome editing; CRISPR; Plasmid; Gene; Recombinant DNA; Vector (molecular biology); Genetics; Lamivudine; HBsAg","retraction":null,"screen_n_in":null,"score":{"opus":0.04722707968031607,"gpt":0.4325836836005674,"spread":0.3853566039202513,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001441937,0.0002889531,0.0005480884,0.00005687249,0.00004265638,0.00001831533,0.0003493361,0.0002875541,0.00006045336],"category_scores_gemma":[0.0009309658,0.0002943535,0.0002257757,0.0002509654,0.00008147434,0.00000384333,0.0002131795,0.0002952773,0.0000081006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002593216,"about_ca_system_score_gemma":0.0002163707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004389351,"about_ca_topic_score_gemma":0.00004670261,"domain_scores_codex":[0.996928,0.000628766,0.001211866,0.0006342672,0.0002245509,0.0003724913],"domain_scores_gemma":[0.9989958,0.0001278688,0.000205793,0.0003366171,0.0001340602,0.0001998727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000144215,0.0001367448,0.004013046,0.00002831407,0.0001682297,0.00002028358,0.0001855623,0.0002407348,0.9132506,0.00001175733,0.00005616049,0.08174434],"study_design_scores_gemma":[0.001895918,0.000398884,0.02928841,0.00002723486,0.00001434907,0.000003332509,0.00001234844,0.000360923,0.9439744,0.00003559021,0.02366645,0.0003221758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5973251,0.001859042,0.4001458,0.0001514918,0.0001724987,0.0002453473,0.000003691609,0.00001995036,0.00007704035],"genre_scores_gemma":[0.5365747,0.001981919,0.4594911,0.001562842,0.0002078661,0.00004330234,0.00006699453,0.00005553865,0.00001577282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08142217,"threshold_uncertainty_score":0.9999509,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3139242858","doi":"10.1016/j.omtm.2021.03.016","title":"Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada; McGill University","funders":"National Research Council Canada; Canada Excellence Research Chairs, Government of Canada; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Capsid; Analytical Ultracentrifugation; Ultracentrifuge; Downstream processing; Chromatography; Chemistry; Flocculation; DNA; Virus; Biology; Virology; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.09976642969079455,"gpt":0.4601035992179379,"spread":0.3603371695271433,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005725711,0.0002387531,0.0006012729,0.0001102488,0.00008761231,0.00002135874,0.0001960102,0.0002483107,0.00001875321],"category_scores_gemma":[0.0006006658,0.0002335927,0.0001142895,0.0002525342,0.000120602,0.000006641516,0.0002244276,0.000154107,4.286779e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002911984,"about_ca_system_score_gemma":0.0009935001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004482141,"about_ca_topic_score_gemma":0.0001039628,"domain_scores_codex":[0.9964799,0.001151385,0.001139174,0.0006769442,0.0002128201,0.0003398057],"domain_scores_gemma":[0.9985265,0.0003803256,0.0002367723,0.0003877985,0.0003299972,0.0001385987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00156042,0.0002188018,0.001408848,0.00006010636,0.000346804,0.000002885404,0.0006540202,0.0001628744,0.7968056,0.00004559948,0.000004337138,0.1987297],"study_design_scores_gemma":[0.00274842,0.0008932407,0.008447477,0.00003449104,0.00001758581,0.000004951926,0.0002152114,0.000344082,0.9770598,0.0003352004,0.009619527,0.0002800568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6325687,0.004647822,0.3621447,0.00007460373,0.0000320716,0.000478654,0.000003751944,0.00000481627,0.0000449033],"genre_scores_gemma":[0.06335736,0.001033623,0.9349056,0.0002397541,0.00002017259,0.0001960103,0.00007268742,0.00003786277,0.0001369565],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5727609,"threshold_uncertainty_score":0.9525635,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2912997303","doi":"10.1016/j.omtm.2019.02.003","title":"Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Faculty of Engineering, McGill University; McGill University","keywords":"Insect; Yield (engineering); Biology; Gene; Botany; Genetics; Physics","retraction":null,"screen_n_in":null,"score":{"opus":0.05717033999685368,"gpt":0.344595276994331,"spread":0.2874249369974773,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001863369,0.0003198614,0.0005085883,0.0001288556,0.00009565162,0.00002782311,0.0002667491,0.0003662286,0.00008129393],"category_scores_gemma":[0.0001314031,0.0003002168,0.0002525537,0.0002483365,0.00006731335,0.00001648823,0.00015861,0.0002719572,0.00002282342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007207858,"about_ca_system_score_gemma":0.0002698139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006543236,"about_ca_topic_score_gemma":0.00001538962,"domain_scores_codex":[0.9961909,0.001186268,0.001031509,0.0009038151,0.0003401488,0.0003473759],"domain_scores_gemma":[0.9985245,0.00009482276,0.0003435194,0.0006546734,0.0002086251,0.0001737982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000755798,0.000633776,0.0216462,0.00007677112,0.0001611866,0.00000502667,0.00005370317,0.0008943733,0.9355161,0.00001108647,0.00004652314,0.04019944],"study_design_scores_gemma":[0.00114276,0.0008748338,0.1090342,0.00008384202,0.00002094983,0.000005801528,0.00004432657,0.00004050088,0.8870759,0.00003476808,0.001263046,0.0003790397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560595,0.001350212,0.04013864,0.00003013765,0.00167203,0.0006016145,0.000003899889,0.00003241433,0.000111577],"genre_scores_gemma":[0.9424729,0.0003335783,0.05628025,0.000314354,0.0002183481,0.000088168,0.0001144562,0.0000528245,0.0001250718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.087388,"threshold_uncertainty_score":0.999945,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3105364689","doi":"10.1016/j.omtm.2020.11.002","title":"Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"American University of Sharjah; King Saud University; University of Sharjah; Al Jalila Foundation","keywords":"Immune system; Downregulation and upregulation; Immunology; Biology; Myeloid; Immune dysregulation; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.1377661501299898,"gpt":0.5153187469397839,"spread":0.3775525968097941,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004605374,0.0003709649,0.001292135,0.0001254661,0.0001312449,0.00001768116,0.0002646947,0.0003006663,0.0001249428],"category_scores_gemma":[0.02755578,0.0002979895,0.0008704956,0.0005045044,0.0002781555,0.00007023953,0.0004677603,0.0008946648,0.00005287792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645926,"about_ca_system_score_gemma":0.0004622939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002460506,"about_ca_topic_score_gemma":5.649023e-7,"domain_scores_codex":[0.9938386,0.001551362,0.002438186,0.0008648864,0.0007992297,0.0005077353],"domain_scores_gemma":[0.9959026,0.00233562,0.000524232,0.0005639255,0.0003502839,0.0003233419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001830038,0.0004181666,0.002264154,0.000233116,0.0003733857,0.0000183221,0.0006697277,0.000009561963,0.8271235,0.000007165589,0.000016142,0.1670367],"study_design_scores_gemma":[0.003810263,0.000948393,0.07126641,0.0002702561,0.00003817615,4.491087e-7,0.00001718628,0.00004882937,0.9106467,0.0001486765,0.01253696,0.0002676393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7758321,0.0004008583,0.220203,0.002224862,0.0002991061,0.0008000847,8.820761e-7,0.0001119804,0.000127158],"genre_scores_gemma":[0.7212122,0.002566731,0.2730858,0.002724029,0.0001400773,0.0001194612,0.00001153092,0.00006095308,0.00007918312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.166769,"threshold_uncertainty_score":0.9999472,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2042183771","doi":"10.1038/mtm.2013.5","title":"Targeted CNS delivery using human MiniPromoters and demonstrated compatibility with adeno-associated viral vectors","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Child and Family Research Institute; University of British Columbia","funders":"National Institute of General Medical Sciences; National Eye Institute; National Institutes of Health; Genome British Columbia; Research to Prevent Blindness; Child and Family Research Institute; Michael Smith Health Research BC; Macula Vision Research Foundation; GlaxoSmithKline; Canadian Institutes of Health Research; Genome Canada","keywords":"Biology; Adeno-associated virus; Gene; Gene expression; Reporter gene; Viral vector; Genetic enhancement; Vectors in gene therapy; Locus (genetics); Genetics; Neuroscience; Vector (molecular biology)","retraction":null,"screen_n_in":null,"score":{"opus":0.04121332399426751,"gpt":0.4150032049627303,"spread":0.3737898809684628,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001877004,0.0003264578,0.0004322016,0.00005331768,0.0001594035,0.00003985599,0.000192026,0.0002752884,0.00001097791],"category_scores_gemma":[0.0001891495,0.0002871806,0.0001156221,0.0001349446,0.0001811184,0.00000446535,0.00009963718,0.000223749,0.000001093118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003234198,"about_ca_system_score_gemma":0.0001295874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002837644,"about_ca_topic_score_gemma":0.0000239848,"domain_scores_codex":[0.9971836,0.0009170384,0.0006497106,0.0006761853,0.0001899572,0.0003835586],"domain_scores_gemma":[0.9990486,0.00008801197,0.0001600117,0.0003740442,0.0001215907,0.0002077697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140782,0.0001850601,0.02162269,0.0000130338,0.0004724556,0.000006255551,0.0001093246,0.0002963259,0.9284884,0.000008236935,0.00001024276,0.04864715],"study_design_scores_gemma":[0.002682258,0.001056696,0.175916,0.00005247277,0.00007007731,0.00001029448,0.00004371721,0.002217612,0.8140196,0.00009257065,0.003129339,0.0007093519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7481841,0.0004681721,0.2509229,0.00002095226,0.00009535076,0.0002391083,0.000002198218,0.00002913898,0.00003802162],"genre_scores_gemma":[0.74525,0.00004663358,0.2542899,0.0002407775,0.00003334966,0.00001078032,0.00007084854,0.00003816352,0.00001954818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1542933,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3033248840","doi":"10.1016/j.omtm.2020.05.035","title":"Mitigating Deficiencies in Evidence during Regulatory Assessments of Advanced Therapies: A Comparative Study with Other Biologicals","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Northeastern University; Bundesministerium für Bildung und Forschung; Arab-German Young Academy of Sciences and Humanities; Wellcome Trust; McGill University; Wellcome","keywords":"Marketing authorization; Authorization; New product development; Leverage (statistics); Business; Product (mathematics); Flexibility (engineering); Risk analysis (engineering); Medicine; Market access; Marketing; Economics; Computer science; Bioinformatics","retraction":null,"screen_n_in":null,"score":{"opus":0.305684620210304,"gpt":0.5349977181003227,"spread":0.2293130978900187,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003639784,0.0002395899,0.0008591026,0.00007954967,0.0000707352,0.00001317735,0.0001901369,0.0001858744,0.00004482195],"category_scores_gemma":[0.0003643611,0.0001499497,0.0001122448,0.0005751545,0.0005975412,0.00005514154,0.00008129425,0.0004733938,0.000002094619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005928033,"about_ca_system_score_gemma":0.0003315074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006018397,"about_ca_topic_score_gemma":0.000003226903,"domain_scores_codex":[0.9958205,0.001558947,0.001172453,0.000583616,0.0006031921,0.000261263],"domain_scores_gemma":[0.9981562,0.0008167558,0.0003766243,0.0002699251,0.0001876277,0.0001928621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004009117,0.002098504,0.1434438,0.0001856727,0.0008016377,0.00006831978,0.01988145,0.0001729023,0.6040812,0.0002044191,0.000001275638,0.2250517],"study_design_scores_gemma":[0.006165545,0.004019149,0.8797743,0.0008209159,0.00003647612,0.000003408244,0.005324255,0.0002849212,0.1024208,0.0002831738,0.0005517324,0.0003153654],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657221,0.00172532,0.02988437,0.001373738,0.00004419907,0.001155584,6.431745e-7,0.00003644375,0.00005754977],"genre_scores_gemma":[0.6868487,0.0001079924,0.31193,0.00101773,0.00001406105,0.00005455099,0.000001727908,0.00001443136,0.00001079438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7363305,"threshold_uncertainty_score":0.6114773,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2294701818","doi":"10.1038/mtm.2015.57","title":"Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; SickKids Foundation; Toronto Metropolitan University; Queen's University; University of Manitoba; Genome Canada","funders":"Hospital for Sick Children","keywords":"Sandhoff disease; HEXA; Protein subunit; Hexosaminidase; Ganglioside; Biology; Biochemistry; HEK 293 cells; Gangliosidosis; POU domain; Gene; Molecular biology; Gene expression; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.08583268542987384,"gpt":0.4140377996367121,"spread":0.3282051142068383,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004273354,0.0002849541,0.001008059,0.0004009666,0.00005174421,0.000009794479,0.0002707677,0.000166672,0.0004405032],"category_scores_gemma":[0.001215315,0.000208119,0.0002741429,0.0005339191,0.0004252396,0.0001215564,0.0001249202,0.0003089991,0.000008825882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001860374,"about_ca_system_score_gemma":0.0007071445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001331445,"about_ca_topic_score_gemma":0.00001257404,"domain_scores_codex":[0.9957483,0.001011301,0.001386856,0.0005515226,0.0007319657,0.0005700965],"domain_scores_gemma":[0.9974772,0.001016254,0.000396528,0.000571293,0.0002837473,0.0002549988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001566681,0.0007572744,0.07208902,0.0001375404,0.0004506979,0.0002165221,0.0003801786,0.000004609258,0.4695053,0.00009560107,0.00003497421,0.4547616],"study_design_scores_gemma":[0.005873164,0.0004817116,0.009675746,0.0003770928,0.00003520963,0.00004647834,0.0002162301,0.00007156971,0.9772005,0.001017098,0.004752191,0.000252982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9140367,0.001234947,0.08277496,0.0003053326,0.0001455991,0.0008026694,0.000007767992,0.00002848721,0.0006635744],"genre_scores_gemma":[0.6615232,0.0007133645,0.3370391,0.0002237378,0.00001562039,0.00007309089,0.00000637912,0.00005122309,0.0003542526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5076952,"threshold_uncertainty_score":0.8486845,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2067752745","doi":"10.1038/mtm.2014.44","title":"An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Frataxin; Biology; Ataxia; Gene knockout; Cre recombinase; Molecular biology; Knockout mouse; Transgene; Gene; Genetically modified mouse; Genetics; Iron-binding proteins; Neuroscience","retraction":null,"screen_n_in":null,"score":{"opus":0.1116412643572987,"gpt":0.4118556187344615,"spread":0.3002143543771628,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004808043,0.0003334052,0.0004916079,0.00005011739,0.0004163013,0.0001359785,0.0009359079,0.0001330878,0.000009466885],"category_scores_gemma":[0.003467006,0.0001975715,0.0001850763,0.0002106915,0.0004807527,0.0001000729,0.0001820176,0.0003152286,0.000002246439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001273646,"about_ca_system_score_gemma":0.0002245316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005302667,"about_ca_topic_score_gemma":0.00000257143,"domain_scores_codex":[0.9926258,0.004672692,0.0009625022,0.0009166822,0.0003916367,0.0004306787],"domain_scores_gemma":[0.9951996,0.00301067,0.0003836133,0.0009764001,0.0001719966,0.000257747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000408468,0.0002294594,0.0002929179,0.00001593683,0.00007071502,7.632041e-7,0.0006476868,0.0002930585,0.8592258,0.002372377,0.00002309213,0.1364197],"study_design_scores_gemma":[0.001400105,0.0006763015,0.004034137,0.00001051369,0.00003839925,0.00000143468,0.00004926868,0.02740695,0.9600646,0.003244969,0.002788278,0.0002850301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.612247,0.0002295346,0.3856586,0.0005072211,0.0001352567,0.001159641,0.0000101863,0.00003469889,0.00001788654],"genre_scores_gemma":[0.8411283,0.0001630588,0.1513546,0.006791591,0.00005867311,0.0003871016,0.000004752766,0.00006312142,0.00004874121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.234304,"threshold_uncertainty_score":0.8056734,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2883800592","doi":"10.1016/j.omtm.2018.07.004","title":"Accurate Titration of Infectious AAV Particles Requires Measurement of Biologically Active Vector Genomes and Suitable Controls","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Université de Nantes; Commissariat Général à l'Investissement; Centre hospitalier universitaire Sainte-Justine; Agence Nationale de la Recherche; Institut National de la Santé et de la Recherche Médicale; Association Française contre les Myopathies","keywords":"Genome; Biology; Infectivity; Vector (molecular biology); Virology; Viral vector; Intracellular; Computational biology; Transgene; Virus quantification; Virus; Recombinant DNA; Gene; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.1191263058718998,"gpt":0.4409644334031738,"spread":0.3218381275312741,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004736475,0.000218805,0.0004649868,0.00006317189,0.00007901772,0.00001915557,0.0002345277,0.0002343928,0.00005270084],"category_scores_gemma":[0.0008807282,0.0001749092,0.0001400844,0.000156411,0.0004506207,0.000007896674,0.000123317,0.0001320277,0.000005080733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003163404,"about_ca_system_score_gemma":0.0003694558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000886241,"about_ca_topic_score_gemma":0.00004304526,"domain_scores_codex":[0.9963937,0.001609655,0.0008449405,0.000491266,0.0003340071,0.000326439],"domain_scores_gemma":[0.9983054,0.0001842901,0.0003355462,0.0003882198,0.000657928,0.0001286442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002820555,0.000213098,0.001881858,0.00001118363,0.0004654446,0.000001082642,0.0001100282,0.000006829056,0.7989751,0.00004330916,0.00001381021,0.1954577],"study_design_scores_gemma":[0.001715792,0.005878685,0.01651707,0.00001908353,0.00001764705,0.000001533113,0.00002925872,0.0000321185,0.9701003,0.0004840704,0.00500884,0.0001955546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509133,0.003348666,0.04480805,0.0001145272,0.0001192672,0.0005423278,0.000006110075,0.00001279279,0.0001349639],"genre_scores_gemma":[0.9498175,0.0016825,0.0479945,0.0003049732,0.00007379884,0.00005906483,0.00001450076,0.00002482185,0.00002837326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1952621,"threshold_uncertainty_score":0.713259,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2886873203","doi":"10.1016/j.omtm.2018.07.010","title":"Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Guelph","funders":"Office for Victims of Crime; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs; Cystic Fibrosis Canada","keywords":"Oncolytic virus; Ex vivo; Genetic enhancement; Virology; In vivo; Viral therapy; Viral vector; Computational biology; Gene; Biology; Cancer research; Coronavirus disease 2019 (COVID-19); Medicine; Virus; Pathology; Biotechnology; Genetics; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.215142387131853,"gpt":0.5367650819644555,"spread":0.3216226948326025,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006297805,0.0003798512,0.0005807848,0.0001073985,0.0002397571,0.0001043083,0.0003555255,0.000339816,0.00003341054],"category_scores_gemma":[0.001411274,0.0003236259,0.0002130063,0.0001273307,0.0003722113,0.00002416938,0.0001585157,0.0001380706,0.000001128191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003074458,"about_ca_system_score_gemma":0.0004936478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207754,"about_ca_topic_score_gemma":0.00002094555,"domain_scores_codex":[0.9957606,0.00138541,0.0009949409,0.0009996339,0.0003655525,0.0004939138],"domain_scores_gemma":[0.9972196,0.001078844,0.0003104053,0.0006354089,0.0005303824,0.000225368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007842923,0.000164045,0.0007683317,0.00001720569,0.0003450504,6.427784e-7,0.000192829,0.000005516285,0.6132586,0.00001391634,0.00002633936,0.3773646],"study_design_scores_gemma":[0.003507776,0.01534603,0.001942421,0.00003055913,0.00003239294,0.000003633522,0.00002687576,0.001029928,0.9560632,0.0008547255,0.02074423,0.0004182748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9046794,0.002657715,0.0903049,0.00006142319,0.0001767464,0.002070717,0.00002281841,0.00001792566,0.000008355255],"genre_scores_gemma":[0.2117808,0.002248813,0.782703,0.002152287,0.0002788119,0.0005118937,0.00005490931,0.0001261287,0.0001433934],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6928986,"threshold_uncertainty_score":0.9999216,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2926378013","doi":"10.1016/j.omtm.2019.03.005","title":"PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; Health Sciences Centre Foundation; National Institute of General Medical Sciences; California Institute for Regenerative Medicine","keywords":"Transduction (biophysics); Genetic enhancement; Haematopoiesis; Progenitor cell; Viral vector; Biology; Transgene; Stem cell; Cancer research; Immunology; Cell biology; Gene; Genetics; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.0413253131754646,"gpt":0.4271386880818766,"spread":0.385813374906412,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002399834,0.0003265769,0.0005436275,0.00008427213,0.00008632063,0.00002545794,0.0003312708,0.0002663202,0.000141345],"category_scores_gemma":[0.0000508303,0.0002738475,0.0001777572,0.0001996559,0.000298896,0.000008802024,0.00009414971,0.0002965192,0.00001494931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003461317,"about_ca_system_score_gemma":0.0003197722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001539517,"about_ca_topic_score_gemma":0.00003162556,"domain_scores_codex":[0.9964107,0.00123337,0.000705816,0.000835899,0.0003657553,0.000448404],"domain_scores_gemma":[0.9987707,0.00007632541,0.0002037895,0.000644547,0.0001521606,0.0001525085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002343283,0.0002362309,0.002145895,0.00003013644,0.0004209467,0.000003883336,0.0001217239,0.000008997736,0.8743165,0.00003608271,0.00001205539,0.1203243],"study_design_scores_gemma":[0.002117235,0.006136722,0.007625361,0.00004404095,0.00001905148,0.000006672212,0.00003692685,0.000009079907,0.9776294,0.00008487382,0.005924727,0.0003659021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739531,0.002905997,0.02195978,0.0001660612,0.0001374728,0.0006952762,0.000003711333,0.00001852641,0.000160114],"genre_scores_gemma":[0.945028,0.0009671619,0.05277089,0.0004168114,0.00006033313,0.00007361742,0.00004424197,0.0000687604,0.0005701421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1199584,"threshold_uncertainty_score":0.9999714,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2613512540","doi":"10.1016/j.omtm.2017.05.003","title":"Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34 + Cells for Correction of Fabry Disease","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true},"ca_institutions":"University of British Columbia; University of Guelph; Western University; Juravinski Hospital; Université de Sherbrooke; Calgary Laboratory Services; Dalhousie University; University Health Network; University of Toronto; Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary; Kidney Foundation of Canada; University of Calgary; Alberta Health Services","keywords":"CD34; Fabry disease; Haematopoiesis; Genetic enhancement; Hematopoietic stem cell transplantation; Xenotransplantation; Viral vector; Stem cell; Transplantation; Ex vivo; Immunology; Cancer research; Medicine; Recombinant DNA; Biology; Internal medicine; In vivo; Disease; Cell biology; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.1693160542515036,"gpt":0.5115581452344975,"spread":0.3422420909829939,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006744921,0.0002983604,0.0008968224,0.000099422,0.0005130906,0.0001039493,0.0003235964,0.0002569424,0.00006111017],"category_scores_gemma":[0.01572276,0.0002553672,0.0004011174,0.0001405816,0.0005200364,0.0001108501,0.0002247055,0.0004875097,0.000005528952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006837309,"about_ca_system_score_gemma":0.0006307548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000212603,"about_ca_topic_score_gemma":0.000004297911,"domain_scores_codex":[0.9952922,0.001374968,0.0015775,0.0008482562,0.0004805832,0.0004265152],"domain_scores_gemma":[0.9945173,0.00287524,0.0006183709,0.0007405445,0.0007007418,0.0005478592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003501605,0.001411856,0.1282094,0.000165838,0.0004185624,0.00001954029,0.0003504085,0.00000810602,0.1019245,0.00001129663,0.0002567382,0.7637221],"study_design_scores_gemma":[0.01335697,0.001836137,0.7453519,0.0004307266,0.0002439545,0.000005076918,0.0001088163,0.01390728,0.2084269,0.0007845448,0.01486305,0.0006846268],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.701221,0.0006494946,0.2949414,0.00031384,0.0009240955,0.001779583,0.000009029624,0.00004444013,0.0001170889],"genre_scores_gemma":[0.4946472,0.0003320458,0.503214,0.0003882837,0.0001356096,0.0002645759,0.00003664549,0.00005540893,0.0009262383],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7630375,"threshold_uncertainty_score":0.9999899,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2766107001","doi":"10.1016/j.omtm.2017.10.004","title":"Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Juravinski Cancer Centre; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Oncolytic virus; Newcastle disease; Embryonated; Virus; Virology; Titer; Biology; Mononegavirales; Microbiology; Paramyxoviridae; Viral disease","retraction":null,"screen_n_in":null,"score":{"opus":0.225310428922894,"gpt":0.503903824089291,"spread":0.278593395166397,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002973351,0.0001874994,0.0004016729,0.00007301889,0.00008433699,0.00003214016,0.0003521628,0.0001993341,0.000008987898],"category_scores_gemma":[0.001302019,0.0001706459,0.0001464466,0.0000550642,0.0002805086,0.00001998671,0.0001374552,0.0001382582,4.521752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002093871,"about_ca_system_score_gemma":0.000336721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008879062,"about_ca_topic_score_gemma":0.0002280759,"domain_scores_codex":[0.9973647,0.0006533537,0.0008663067,0.000658199,0.0002150552,0.0002424122],"domain_scores_gemma":[0.9980953,0.0001336752,0.0004103861,0.0009391244,0.0002736731,0.0001478134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008153461,0.0004619876,0.009066949,0.0000472328,0.0001944157,0.00000103615,0.00006072355,0.0003620934,0.7288137,0.00004323973,0.00002423537,0.2527709],"study_design_scores_gemma":[0.001686062,0.0007081807,0.04501847,0.0000457077,0.00001938619,2.341687e-7,0.000004794717,0.0004065899,0.9494308,0.0009753823,0.001504941,0.0001994938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9461431,0.001765049,0.0506249,0.0003518405,0.0001545176,0.0009217179,0.00002978155,0.000005245455,0.000003862946],"genre_scores_gemma":[0.7601912,0.004473134,0.2343806,0.0001811565,0.00007863319,0.0003419291,0.00004983449,0.00004586656,0.0002575936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2525714,"threshold_uncertainty_score":0.6958736,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3168161702","doi":"10.1016/j.omtm.2021.06.003","title":"Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Nucleoprotein; Immunogenicity; Neuraminidase; Virology; Hemagglutinin (influenza); Viral matrix protein; Virus; Antigen; Influenza A virus; Antigenic drift; Reactogenicity; Biology; Nucleoside; Chemistry; Immunology; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.2372756409045055,"gpt":0.5270980774313304,"spread":0.2898224365268249,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00462488,0.0004686824,0.001117053,0.000320183,0.000216287,0.00007357183,0.0003831014,0.0003560221,0.0001500069],"category_scores_gemma":[0.004091424,0.0004160845,0.0004016889,0.0009844035,0.0001838101,0.00008458464,0.0002361412,0.0008982391,0.0001150693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002553635,"about_ca_system_score_gemma":0.001837553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008633499,"about_ca_topic_score_gemma":0.00003963791,"domain_scores_codex":[0.9934991,0.001912481,0.001955494,0.001088295,0.0007334298,0.0008112286],"domain_scores_gemma":[0.9961257,0.001393666,0.0002729496,0.000988336,0.0008267774,0.0003925612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001233415,0.001599347,0.01505253,0.00007585691,0.0007637044,0.0004040065,0.0005469376,0.0001681308,0.5750993,0.0002235565,0.0001440113,0.4046892],"study_design_scores_gemma":[0.007245697,0.0002265512,0.1840986,0.0001291383,0.00003226805,0.000006548275,0.00009704026,0.0008258575,0.701506,0.0005883935,0.1047251,0.0005188868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9118851,0.008036708,0.07399441,0.002718166,0.0003985278,0.001491585,0.00001103675,0.0001545316,0.001309924],"genre_scores_gemma":[0.09710388,0.003316328,0.8768071,0.0215774,0.000134186,0.0005472771,0.00004913061,0.0001316858,0.0003330304],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8147812,"threshold_uncertainty_score":0.9998291,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3024777633","doi":"10.1016/j.omtm.2020.05.002","title":"Allele-Specific Prevention of Nonsense-Mediated Decay in Cystic Fibrosis Using Homology-Independent Genome Editing","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Cystic Fibrosis Canada","keywords":"Cystic fibrosis; Nonsense; Allele; Genetics; Genome editing; Genome; Homology (biology); Biology; Computational biology; Evolutionary biology; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.1402007187031849,"gpt":0.4556116660790647,"spread":0.3154109473758798,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004445754,0.0003442995,0.001131515,0.0002500786,0.00007302179,0.00002365843,0.0002985599,0.0002849837,0.0002753106],"category_scores_gemma":[0.001923386,0.0003178304,0.0003182106,0.0007609276,0.0002328933,0.00006857485,0.000199851,0.0007108464,0.00003310464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022009,"about_ca_system_score_gemma":0.0006263165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001024216,"about_ca_topic_score_gemma":0.00000421799,"domain_scores_codex":[0.9935571,0.002106755,0.002038705,0.0008570714,0.0008116729,0.0006286917],"domain_scores_gemma":[0.9968533,0.001548056,0.0004459713,0.0004245655,0.0002642073,0.0004638939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002251557,0.000624565,0.007734207,0.0001649267,0.0003387819,0.0003428089,0.000670056,0.0002696947,0.8034228,0.00003153746,0.00001837313,0.1841307],"study_design_scores_gemma":[0.01719204,0.004211436,0.2774763,0.0009790235,0.0001414544,0.0001308448,0.0006412524,0.003543012,0.628434,0.0007417433,0.06528152,0.001227396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6389176,0.003549671,0.3557019,0.0005830079,0.0001533276,0.0009730739,0.000006027161,0.00004817544,0.00006716644],"genre_scores_gemma":[0.2434235,0.0006760862,0.7550589,0.0004821735,0.0001209093,0.00007678923,0.00008158802,0.00006016009,0.0000199463],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.399357,"threshold_uncertainty_score":0.9999274,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4213184823","doi":"10.1016/j.omtm.2022.02.004","title":"Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Stemcell Technologies; University of Victoria","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Victoria University; Cancer Prevention and Research Institute of Texas","keywords":"Ex vivo; Glutamine; In vivo; Phenotype; Function (biology); Cell biology; Cell growth; Biology; Cell; T cell; Carbohydrate metabolism; Metabolism; Cancer research; Biochemistry; Immunology; Immune system; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.09640898408945156,"gpt":0.4155556623956408,"spread":0.3191466783061893,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01374629,0.0007255382,0.001772284,0.0002820119,0.0005000447,0.00009337097,0.0007601231,0.000417603,0.007396373],"category_scores_gemma":[0.001094364,0.0006208961,0.00101739,0.001066209,0.0002833224,0.00008429107,0.0007138061,0.002451529,0.0001432681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003487552,"about_ca_system_score_gemma":0.001313285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008951876,"about_ca_topic_score_gemma":0.000006375968,"domain_scores_codex":[0.9858848,0.005979526,0.002889523,0.001844137,0.002330384,0.001071574],"domain_scores_gemma":[0.9935594,0.002822699,0.0006957073,0.001670352,0.0003658909,0.0008859682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005691476,0.001939333,0.004767325,0.00001725728,0.0006511827,0.0002217705,0.0005016782,0.000009149187,0.4029295,0.00001740005,0.00007172777,0.5831823],"study_design_scores_gemma":[0.01258289,0.003128981,0.04177662,0.00007017049,0.0003472609,0.00001340196,0.0004169898,0.0005598367,0.2985832,0.002103134,0.6393805,0.001037012],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8737716,0.003681914,0.1165381,0.0007223553,0.001947443,0.002395744,0.00001327143,0.0003085874,0.0006209349],"genre_scores_gemma":[0.4272738,0.002339031,0.5588727,0.004264825,0.000738467,0.001551384,0.001364592,0.0004070318,0.003188124],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6393088,"threshold_uncertainty_score":0.9998499,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2836414657","doi":"10.1016/j.omtm.2018.06.009","title":"UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; University of British Columbia; Institute for Research in Immunology and Cancer; BC Cancer Agency","funders":"BC Cancer Agency; Terry Fox Foundation; Stem Cell Network","keywords":"Gene transfer; Haematopoiesis; Gene; Biology; Virology; Cell biology; Stem cell; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.0666723510200596,"gpt":0.433455202140979,"spread":0.3667828511209195,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003315573,0.0003374619,0.0005458443,0.00009508435,0.0001528854,0.00003210004,0.0004012971,0.0003126592,0.0001074543],"category_scores_gemma":[0.00009438604,0.000305768,0.0002599206,0.0001712226,0.0006695127,0.000007544739,0.0001578041,0.0002262899,0.00001527503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002116957,"about_ca_system_score_gemma":0.0002690491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005169286,"about_ca_topic_score_gemma":0.00001802011,"domain_scores_codex":[0.9958996,0.00152398,0.0009292478,0.0008310413,0.0003492663,0.0004669312],"domain_scores_gemma":[0.9987248,0.0001299809,0.0001361485,0.0005722505,0.0002506888,0.0001861649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001419331,0.0002429364,0.0001511267,0.00001881134,0.0003967036,0.00000528657,0.0002145178,9.072818e-7,0.849957,0.00002629123,0.00002979281,0.1475373],"study_design_scores_gemma":[0.001493665,0.004940673,0.001773038,0.00003083626,0.00001995616,0.000004003509,0.00003493029,0.000004065656,0.9838826,0.0004894556,0.006965824,0.0003609491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8969436,0.002114017,0.09983082,0.00006752396,0.0002014827,0.0004836324,0.000006931282,0.00001524471,0.0003367712],"genre_scores_gemma":[0.8128847,0.002384864,0.1829319,0.0009448777,0.0001823869,0.00008003217,0.00004377688,0.0000785481,0.0004688886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1471763,"threshold_uncertainty_score":0.9999394,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4305081949","doi":"10.1016/j.omtm.2022.10.009","title":"LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"CRISPR; Transgene; Genetically modified mouse; Proof of concept; Chemistry; Cell biology; Biology; Computational biology; Molecular biology; Biochemistry; Computer science; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.0395217700568771,"gpt":0.4168500194878031,"spread":0.377328249430926,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00207984,0.0003272555,0.000478035,0.0001156554,0.00009753663,0.00001548951,0.0004047825,0.0001310784,0.00002563505],"category_scores_gemma":[0.0000534327,0.0003024364,0.0001997623,0.0002748315,0.00007877129,0.000004785536,0.0001672531,0.0003729864,4.90626e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005271179,"about_ca_system_score_gemma":0.000268071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008877236,"about_ca_topic_score_gemma":0.00001977345,"domain_scores_codex":[0.9966705,0.0008400421,0.0009202851,0.0007581827,0.0004151918,0.0003958358],"domain_scores_gemma":[0.9990516,0.00005281481,0.0001592806,0.0005349556,0.00006870937,0.0001326373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001937991,0.002677926,0.003911457,0.00002872959,0.0006672948,0.00002925028,0.002633839,0.2823256,0.412147,0.00001588708,0.00002330732,0.2936018],"study_design_scores_gemma":[0.004817373,0.002671612,0.001811068,0.00001382162,0.00004196665,0.000006304139,0.0007331406,0.00520196,0.9803171,0.000056527,0.003744828,0.0005843585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5629141,0.0003599624,0.4358634,0.00005240719,0.00009144223,0.0006784719,0.000005305124,0.0000126549,0.00002217551],"genre_scores_gemma":[0.8119401,0.00007292796,0.1871671,0.0001815829,0.00002054622,0.0003316151,0.0000495363,0.00006310467,0.0001735197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5681701,"threshold_uncertainty_score":0.9999428,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4324342851","doi":"10.1016/j.omtm.2023.03.006","title":"Simultaneous engineering of natural killer cells for CAR transgenesis and CRISPR-Cas9 knockout using retroviral particles","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada; Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"National Cancer Institute; National Research Council Canada; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"CRISPR; Transgenesis; Biology; Cas9; Genetics; Computational biology; Gene; Reproductive technology","retraction":null,"screen_n_in":null,"score":{"opus":0.1189124007392817,"gpt":0.4657807527445325,"spread":0.3468683520052508,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003293771,0.000304907,0.0008299676,0.0002152318,0.00008624936,0.00002664267,0.0001718834,0.000225027,0.00007857849],"category_scores_gemma":[0.0008073324,0.0002645172,0.0003568471,0.000490892,0.0001324296,0.00003442465,0.00007400356,0.0003394766,0.000005185362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008787936,"about_ca_system_score_gemma":0.000234713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001256472,"about_ca_topic_score_gemma":0.000001218296,"domain_scores_codex":[0.9968852,0.0004619888,0.001011886,0.000577914,0.0004655818,0.0005973759],"domain_scores_gemma":[0.9967629,0.002227393,0.0001202776,0.0003891642,0.000225386,0.0002748271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007429131,0.00008312243,0.000385196,0.0001064208,0.0003924666,0.00006080596,0.0004504201,0.0004069698,0.6632996,0.000008974609,0.00001451356,0.3340486],"study_design_scores_gemma":[0.003597673,0.0005373242,0.003151087,0.00009899824,0.00009266668,0.00001536977,0.000103555,0.0386411,0.9276743,0.00006989024,0.02566931,0.0003487403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8966511,0.001462965,0.09994093,0.0002048624,0.0005979339,0.001032664,0.000003297232,0.00009709768,0.000009122493],"genre_scores_gemma":[0.4564626,0.0007701081,0.5414327,0.0003068174,0.00008949675,0.00006399801,0.00001447544,0.0001034118,0.0007564027],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4414918,"threshold_uncertainty_score":0.9999807,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3115551619","doi":"10.1016/j.omtm.2020.12.010","title":"Human-specific GAPDH qRT-PCR is an accurate and sensitive method of xenograft metastasis quantification","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Metastasis; Glyceraldehyde 3-phosphate dehydrogenase; Cancer research; Ex vivo; Cancer; Real-time polymerase chain reaction; Biology; In vivo; Medicine; Gene; Messenger RNA; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.1791411477686859,"gpt":0.4852018502338838,"spread":0.306060702465198,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002521211,0.0003439304,0.0005665349,0.0000619084,0.000154651,0.00003554373,0.0003645134,0.0003776894,0.00003445481],"category_scores_gemma":[0.0001240872,0.0003186255,0.0002498596,0.000255902,0.0002412696,0.000007802606,0.0002065812,0.0002534247,0.000005653128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009968945,"about_ca_system_score_gemma":0.00009236349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007644598,"about_ca_topic_score_gemma":0.000001996161,"domain_scores_codex":[0.9956506,0.001738351,0.0010407,0.001083742,0.0001901371,0.000296464],"domain_scores_gemma":[0.9982677,0.00008404372,0.0004128802,0.0006970495,0.0002664694,0.0002719261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009809486,0.0001451656,0.0001443864,0.000009950794,0.0002479205,0.000003374779,0.0002144572,0.000004713365,0.7566102,0.0005957196,0.0001569658,0.241769],"study_design_scores_gemma":[0.0005560315,0.0005199526,0.003429016,0.000008350071,0.00003454796,0.000007564752,0.00006873618,0.0001011296,0.8361503,0.0003650492,0.1584286,0.0003306608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2866672,0.0009155991,0.7108675,0.0009014489,0.00003320569,0.0004866769,0.00002106699,0.00003495409,0.00007239149],"genre_scores_gemma":[0.1924435,0.001371201,0.802075,0.003624574,0.00005798095,0.0001010069,0.0002455933,0.00004998962,0.000031096],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2414384,"threshold_uncertainty_score":0.9999266,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2898152091","doi":"10.1016/j.omtm.2018.10.011","title":"Efficacy of a Bicistronic Vector for Correction of Sandhoff Disease in a Mouse Model","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Kyowa Hakko Kirin; Research to Prevent Blindness","keywords":"Sandhoff disease; HEXA; Hexosaminidase; Tay-Sachs disease; Genetic enhancement; Gangliosidosis; Biology; Vector (molecular biology); Molecular biology; Enzyme; Gene; Internal medicine; Biochemistry; Medicine; Disease; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.1126639016956874,"gpt":0.4863849579797693,"spread":0.3737210562840819,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002578479,0.0001906641,0.000664416,0.0001970735,0.00003843261,0.000006069533,0.0001970225,0.0001467947,0.00004919851],"category_scores_gemma":[0.002477743,0.0001626101,0.000303941,0.0003482516,0.0002523942,0.00002712402,0.00006976217,0.0002256507,0.000004603785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001315412,"about_ca_system_score_gemma":0.00098768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002318819,"about_ca_topic_score_gemma":0.000007445902,"domain_scores_codex":[0.9971945,0.0005137899,0.001079118,0.0004511821,0.0004135595,0.000347804],"domain_scores_gemma":[0.9982011,0.0005373649,0.0002153414,0.0004424604,0.0003680653,0.0002356741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02290392,0.003960493,0.01529739,0.0002071734,0.0005060071,0.00001347046,0.0009841013,0.0002822243,0.2638168,0.0001137641,0.0001061621,0.6918085],"study_design_scores_gemma":[0.02086749,0.002803569,0.1070054,0.0002974086,0.00008870143,0.000001493973,0.00005600818,0.05776196,0.8055945,0.0007223519,0.004374251,0.0004269063],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7008871,0.0004567204,0.2971577,0.0001201216,0.000171926,0.001124161,0.000004484811,0.00001766098,0.00006016621],"genre_scores_gemma":[0.6742764,0.0001318833,0.324631,0.0002102967,0.00003581901,0.0001487571,0.00001958622,0.00004184776,0.000504425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6913816,"threshold_uncertainty_score":0.6631049,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2325834977","doi":"10.1038/mtm.2014.5","title":"Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Pneumococcal pneumonia; Streptococcus pneumoniae; Immunology; Biology; Innate immune system; Interferon; Immune system; Pneumonia; Pneumococcal infections; Interferon gamma; Inflammation; Microbiology; Medicine; Antibiotics","retraction":null,"screen_n_in":null,"score":{"opus":0.05999596307404485,"gpt":0.4004160799770817,"spread":0.3404201169030368,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002674131,0.000457155,0.0007750055,0.0002307293,0.0002861744,0.00004983205,0.0001672379,0.0003865723,0.00007142173],"category_scores_gemma":[0.0005489586,0.0003725694,0.0003584218,0.0005082666,0.00016456,0.0001060357,0.00007141125,0.0008105717,0.00007750052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595917,"about_ca_system_score_gemma":0.0002996445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001135102,"about_ca_topic_score_gemma":0.000006674251,"domain_scores_codex":[0.9954975,0.001617687,0.001249606,0.0007696314,0.0003595943,0.0005060388],"domain_scores_gemma":[0.9980888,0.0005930836,0.0001931097,0.0005143853,0.0002836181,0.0003269435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000160595,0.0003316888,0.01273351,0.00002587006,0.0002560386,0.0000251699,0.0001409546,0.00001841035,0.5863537,0.00001030739,0.000002763627,0.399941],"study_design_scores_gemma":[0.001317569,0.001239154,0.1364194,0.0001617421,0.00005786056,0.00002547118,0.00001781597,0.0003903618,0.7964301,0.0001272473,0.06333745,0.0004758906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7619632,0.0002294836,0.2352088,0.0003053882,0.0007593861,0.0006236896,9.087165e-7,0.000176818,0.0007322643],"genre_scores_gemma":[0.9642114,0.0008889879,0.03081137,0.003455796,0.0002266648,0.0001688162,0.00003407502,0.00008861398,0.0001143018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3994651,"threshold_uncertainty_score":0.9998726,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3003639078","doi":"10.1016/j.omtm.2020.01.009","title":"A Rapid and Sensitive Nucleic Acid Amplification Technique for Mycoplasma Screening of Cell Therapy Products","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true},"ca_institutions":"Terry Fox Research Institute; Simon Fraser University; Ottawa Hospital; University of British Columbia; University of Victoria; Canada's Michael Smith Genome Sciences Centre","funders":"Networks of Centres of Excellence of Canada; BC Cancer Foundation; Canada Foundation for Innovation","keywords":"Mycoplasma; Nucleic acid; Nat; genomic DNA; Biology; Microbiology; DNA; Virology; Computational biology; Genetics; Computer science","retraction":null,"screen_n_in":null,"score":{"opus":0.1275637233824634,"gpt":0.4086803855476761,"spread":0.2811166621652126,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002348275,0.0002147394,0.0004665634,0.00008900621,0.000170491,0.00001952302,0.0001521847,0.0002640473,0.00007742601],"category_scores_gemma":[0.0004432852,0.0001851518,0.0001585216,0.000258499,0.0002212879,0.00003955657,0.00008357615,0.0002948309,0.00001620872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001610769,"about_ca_system_score_gemma":0.0002226984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005517134,"about_ca_topic_score_gemma":2.271008e-7,"domain_scores_codex":[0.9969758,0.001407784,0.0006820704,0.0005822504,0.00005339934,0.0002987331],"domain_scores_gemma":[0.9986306,0.0004977804,0.0002178077,0.0002573878,0.0003138573,0.00008258034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008326824,0.0002044279,0.00007982278,0.00003529458,0.0002161491,0.000001461155,0.0003109748,7.275565e-7,0.732329,0.00007816301,0.0001084998,0.2658028],"study_design_scores_gemma":[0.001979223,0.0005467361,0.0008109831,0.00002247466,0.00001490014,0.000007904182,0.00006531059,0.000009844195,0.9290936,0.00009703271,0.0671572,0.0001948065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3110913,0.004779349,0.6812307,0.0007981094,0.0001087793,0.001852192,0.00001984078,0.00005408989,0.00006569613],"genre_scores_gemma":[0.3359195,0.00251396,0.6596273,0.001377655,0.00003511556,0.0003007598,0.0001127145,0.00004707399,0.00006593753],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.265608,"threshold_uncertainty_score":0.7550272,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3011051523","doi":"10.1016/j.omtm.2020.03.002","title":"Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Health Canada; Canada Foundation for Innovation; Canadian Bee Research Fund; Fondation Brain Canada","keywords":"CRISPR; Aniridia; Germline; Genome editing; Genetics; Biology; Cas9; PAX6; Gene; Transcription factor","retraction":null,"screen_n_in":null,"score":{"opus":0.06213300370558905,"gpt":0.4431595171498262,"spread":0.3810265134442372,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001668072,0.0003158399,0.0005242323,0.0000659189,0.0000351081,0.00001435547,0.0003619973,0.0003097144,0.00001200779],"category_scores_gemma":[0.0006156102,0.0003108468,0.0002192282,0.0002157819,0.00007367705,0.00000555827,0.0002456451,0.0002800753,0.000004081777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002538209,"about_ca_system_score_gemma":0.0002560346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004026804,"about_ca_topic_score_gemma":0.000002426162,"domain_scores_codex":[0.9971141,0.0003067316,0.001209832,0.0007008187,0.0002808534,0.0003876692],"domain_scores_gemma":[0.9989518,0.00008857127,0.0002180166,0.0003819476,0.0001114734,0.0002482143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002201443,0.0002997248,0.001084462,0.00003373025,0.0001242888,0.000007581385,0.0002925234,0.00836423,0.96056,0.000005541494,0.00002850274,0.02897931],"study_design_scores_gemma":[0.002333987,0.0003074789,0.001932214,0.00002982394,0.00001232758,0.000002066352,0.00001880108,0.01861504,0.9729063,0.00002992365,0.003471612,0.0003404139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4968803,0.0006001096,0.5020005,0.0001700019,0.00008353208,0.0002244719,0.00001147889,0.00001398805,0.00001564308],"genre_scores_gemma":[0.4739924,0.0005370872,0.5240727,0.001056729,0.0001093599,0.00003296066,0.0001028097,0.00005487713,0.0000410639],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0286389,"threshold_uncertainty_score":0.9999344,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3185877187","doi":"10.1016/j.omtm.2021.06.013","title":"Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"FMR1; Fragile X syndrome; Biology; Transgene; Gene isoform; Phenotype; Neuroscience; Adeno-associated virus; Genetic enhancement; Genetics; Gene; Fragile x; Vector (molecular biology)","retraction":null,"screen_n_in":null,"score":{"opus":0.1304001493316821,"gpt":0.4436730021547614,"spread":0.3132728528230794,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001398279,0.0003012194,0.0004104919,0.00005014845,0.0001959396,0.00004609011,0.0001991264,0.0002507778,0.00003968225],"category_scores_gemma":[0.00005242739,0.000296547,0.000151946,0.0001151374,0.0002135153,0.00001426006,0.0002109078,0.0001725812,6.509201e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001847702,"about_ca_system_score_gemma":0.0003071271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002613522,"about_ca_topic_score_gemma":0.00003416791,"domain_scores_codex":[0.9965565,0.001390572,0.0007261089,0.0007400084,0.000269463,0.0003173687],"domain_scores_gemma":[0.9989614,0.00001982024,0.0002420998,0.0004556399,0.000171925,0.0001490877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002002928,0.0006019776,0.00424912,0.000009246893,0.0001258671,0.00001251748,0.0002858716,0.000008839868,0.8785332,0.000009984952,0.000003432449,0.1159597],"study_design_scores_gemma":[0.001205141,0.0007554569,0.08206269,0.0000156952,0.00001307844,0.00001069905,0.0001189189,0.00001688297,0.9130565,0.0001349842,0.002275885,0.0003340729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871756,0.00142883,0.01065919,0.00005830731,0.0001366464,0.0004774095,0.00001138415,0.00001549719,0.00003714129],"genre_scores_gemma":[0.7707793,0.001028507,0.2275681,0.0002704033,0.00001589216,0.00004346486,0.0001858888,0.00004027176,0.00006822024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2169089,"threshold_uncertainty_score":0.9999487,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4394680557","doi":"10.1016/j.omtm.2024.101249","title":"Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Cancer Institute; Grainger Institute for Engineering, University of Wisconsin-Madison; College of Engineering, University of Wisconsin-Madison; National Institute of General Medical Sciences; Engineering Research Centers; Government of the United Kingdom; U.S. Department of Health and Human Services; National Institutes of Health; University of Wisconsin Carbone Cancer Center; St. Baldrick's Foundation; Canadian Thoracic Society; Hyundai Hope On Wheels; National Science Foundation; Michigan Council for Arts and Cultural Affairs; University of Wisconsin-Madison; Division of Graduate Education; National Heart, Lung, and Blood Institute; Wisconsin Alumni Research Foundation","keywords":"CRISPR; Chimeric antigen receptor; Priming (agriculture); Persistence (discontinuity); Cas9; Phenotype; Ribonucleoprotein; Biology; Cell biology; Computational biology; T cell; Genetics; Gene; Engineering; Immune system; RNA","retraction":null,"screen_n_in":null,"score":{"opus":0.102722372450158,"gpt":0.4156942167703084,"spread":0.3129718443201504,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006162406,0.0004833744,0.001201852,0.0003807355,0.0001564865,0.00009031421,0.0004187537,0.0002923221,0.001169623],"category_scores_gemma":[0.0003121774,0.0004087069,0.0006984647,0.0004513127,0.0002213739,0.00011768,0.0002072754,0.0009724243,0.00005632213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001748165,"about_ca_system_score_gemma":0.0007741668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001792656,"about_ca_topic_score_gemma":0.000002841908,"domain_scores_codex":[0.9944297,0.001162798,0.001622641,0.001081296,0.0009413783,0.0007621679],"domain_scores_gemma":[0.9974146,0.00106271,0.000205383,0.0007660294,0.0001810876,0.0003701825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002584871,0.0001782683,0.00005680027,0.0003703331,0.0007425174,0.000131545,0.001922023,0.00001336443,0.6013927,0.00001075763,0.000003557737,0.3949197],"study_design_scores_gemma":[0.001272114,0.000236056,0.004516756,0.0007074633,0.0001421975,0.00003833122,0.0002908505,0.0001490895,0.9771777,0.0001189312,0.01494655,0.0004040019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9510678,0.01386289,0.03167022,0.0002759854,0.0006469743,0.001203999,0.000002535784,0.0001972026,0.001072397],"genre_scores_gemma":[0.4732684,0.002774651,0.5196941,0.0003433469,0.000268854,0.000127607,0.00001277179,0.000180094,0.003330173],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4880239,"threshold_uncertainty_score":0.9998365,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3200548788","doi":"10.1016/j.omtm.2021.05.018","title":"Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö","keywords":"Mesenchymal stem cell; Lung; Medicine; Ex vivo; Cryopreservation; Cell therapy; Lung transplantation; Stromal cell; Transplantation; In vivo; Cell; Cancer research; Pathology; Internal medicine; Biology; Cell biology","retraction":null,"screen_n_in":null,"score":{"opus":0.04920208290050376,"gpt":0.4090646880586772,"spread":0.3598626051581735,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004166825,0.0008890336,0.001561285,0.0002244099,0.0004734881,0.0001355024,0.0006296966,0.0006026546,0.005303686],"category_scores_gemma":[0.0002012073,0.0007977413,0.0007563644,0.000546594,0.0002851635,0.0000953733,0.0005048827,0.001450069,0.00006758465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006838519,"about_ca_system_score_gemma":0.0006350438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002200344,"about_ca_topic_score_gemma":0.000001018989,"domain_scores_codex":[0.990095,0.002673121,0.002158325,0.001866422,0.001787219,0.001419936],"domain_scores_gemma":[0.9963313,0.0005791331,0.0003643089,0.001415601,0.0002662559,0.001043401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007650232,0.001533594,0.01007577,0.0002352704,0.0006866659,0.000707101,0.0007988047,0.000009328447,0.9581143,0.000007785922,0.001210559,0.02585583],"study_design_scores_gemma":[0.01083617,0.0004135329,0.03134195,0.0002099768,0.00008165726,0.00005058735,0.0001458128,0.0009695019,0.929864,0.00001361817,0.02530304,0.0007701783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944214,0.01876331,0.03243253,0.001035583,0.0003569578,0.002099087,0.00001303123,0.0001339736,0.0009514983],"genre_scores_gemma":[0.6470338,0.009295806,0.3281379,0.002521683,0.000288809,0.0003227706,0.0003012347,0.0003603733,0.01173761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2971803,"threshold_uncertainty_score":0.9994473,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3204105047","doi":"10.1016/j.omtm.2021.10.001","title":"Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":29,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; Health Sciences Centre; BC Children's Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Carlsbergfondet; Alzheimer Society; National Institute of Biomedical Imaging and Bioengineering; Weston Brain Institute","keywords":"Gene delivery; Medicine; Microbubbles; Genetic enhancement; Blood–brain barrier; Immune system; Transgene; Immunology; Amyloidosis; Pathology; Central nervous system; Biology; Ultrasound; Gene; Internal medicine; Radiology","retraction":null,"screen_n_in":null,"score":{"opus":0.03098659914967313,"gpt":0.3294280276177547,"spread":0.2984414284680816,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002028644,0.0001486355,0.0003400849,0.00004366077,0.00003358981,0.00001546584,0.0001108064,0.0001074284,0.00001099516],"category_scores_gemma":[0.0002618003,0.0001226283,0.00008309175,0.0002261051,0.00007897457,0.0000272784,0.00003001305,0.0001544501,7.0506e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000274199,"about_ca_system_score_gemma":0.00008109259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006413987,"about_ca_topic_score_gemma":0.00001298693,"domain_scores_codex":[0.9982592,0.000550459,0.0006597773,0.0002420615,0.0001267189,0.0001618209],"domain_scores_gemma":[0.998215,0.001314515,0.00004498041,0.0002836153,0.00006653166,0.00007539117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003526795,0.00009987733,0.0004250782,0.00001987413,0.0001075583,0.000001506257,0.001288156,0.00139287,0.9193127,0.00004669783,0.000004070572,0.07694899],"study_design_scores_gemma":[0.001047791,0.0000580701,0.06219441,0.00004160139,0.00002169231,0.000004256525,0.0001169778,0.001954229,0.9306344,0.0004928645,0.003207195,0.0002265214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.717082,0.001849238,0.2804124,0.0003868042,0.00001748876,0.0001989271,0.00003396323,0.00001299854,0.000006159256],"genre_scores_gemma":[0.7999821,0.001475528,0.1980773,0.0002896448,0.000004762143,0.0001034902,0.00001228678,0.00002049274,0.00003443769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08290009,"threshold_uncertainty_score":0.5000637,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2407212762","doi":"10.1038/mtm.2015.34","title":"Testing gene therapy vectors in human primary nasal epithelial cultures","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Genetic enhancement; Transduction (biophysics); Nasal polyps; Medicine; Mucous membrane of nose; Chloride channel; Apical membrane; Viral vector; Immunology; Cancer research; Gene; Pathology; Epithelium; Cell biology; Biology; Internal medicine; Recombinant DNA; Genetics; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.2047391515779118,"gpt":0.515573003305616,"spread":0.3108338517277042,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007223333,0.0004232826,0.0009832779,0.0002270083,0.000117433,0.00005930422,0.0004067009,0.0002641033,0.00005625984],"category_scores_gemma":[0.003547594,0.0003223018,0.0002241944,0.000661665,0.0002720728,0.00008678344,0.0001721004,0.0008040555,0.00003445509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003566874,"about_ca_system_score_gemma":0.001123255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005281408,"about_ca_topic_score_gemma":0.000005495735,"domain_scores_codex":[0.9940723,0.001881402,0.001425412,0.0008467253,0.001033144,0.000740988],"domain_scores_gemma":[0.997016,0.001118379,0.0002312606,0.0005989841,0.0003916796,0.0006437256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009884178,0.0006007705,0.01932308,0.00001843285,0.0001666431,0.000207747,0.0004355787,0.00001785512,0.5361369,0.00002265314,0.00008969365,0.4419922],"study_design_scores_gemma":[0.01127784,0.001993446,0.4089614,0.0001915761,0.00001617602,0.00004482364,0.00008779772,0.00005734493,0.4911871,0.002118067,0.08345708,0.0006074202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9687492,0.005317175,0.02279075,0.0004542975,0.0003929357,0.001162213,0.000002930417,0.0001396372,0.000990825],"genre_scores_gemma":[0.06839754,0.0003442325,0.9281495,0.002281199,0.0002639729,0.0001750044,0.00006086575,0.00009179293,0.0002359469],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9053587,"threshold_uncertainty_score":0.9999229,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3217726599","doi":"10.1016/j.omtm.2021.11.009","title":"In vivo optogenetic stimulation of the primate retina activates the visual cortex after long-term transduction","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Agence Nationale de la Recherche; Foundation Fighting Blindness; Bpifrance","keywords":"Optogenetics; Neuroscience; Retina; Visual cortex; Channelrhodopsin; Macaque; Photic Stimulation; Stimulation; Retinal; Biology; Primate; Cortex (anatomy); Visual perception","retraction":null,"screen_n_in":null,"score":{"opus":0.08965069262928921,"gpt":0.4807177353700508,"spread":0.3910670427407616,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002256685,0.0002101998,0.0003181778,0.0000651318,0.0001262281,0.00005449841,0.0004685891,0.0001487426,0.0005516725],"category_scores_gemma":[0.0007342824,0.0001336575,0.0002188969,0.0006549447,0.00028856,0.00005460484,0.0001726367,0.0004048982,0.000008355395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007157757,"about_ca_system_score_gemma":0.0003366316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000306363,"about_ca_topic_score_gemma":0.000005252002,"domain_scores_codex":[0.9937946,0.003764762,0.0008402377,0.0006038571,0.0006409915,0.0003555919],"domain_scores_gemma":[0.9981221,0.0009919889,0.0001707321,0.0005068079,0.0001219434,0.00008640296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003238202,0.000311928,0.01441354,0.00001588722,0.00002611726,0.00001931971,0.0004156734,0.00006175834,0.9165975,0.0000157803,0.000003615746,0.06779501],"study_design_scores_gemma":[0.0005456918,0.00006057359,0.2688397,0.00003109392,0.000006954146,0.000005644497,0.000009399598,0.0001699958,0.7288138,0.0002262753,0.001168982,0.0001219706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803581,0.000443186,0.01746882,0.0004400489,0.0005288683,0.000657164,0.000002796356,0.00001292617,0.00008804708],"genre_scores_gemma":[0.976529,0.000894343,0.0208409,0.001377882,0.00003866129,0.000119175,0.000002105372,0.00003470728,0.00016325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2544261,"threshold_uncertainty_score":0.6040426,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2922220912","doi":"10.1016/j.omtm.2019.03.001","title":"Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis","year":2019,"lang":"en","type":"review","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Endophenotype; Medicine; Clinical trial; Context (archaeology); Bioinformatics; Translational research; Disease; Preclinical research; Neuroscience; Biology; Internal medicine; Pathology; Cognition; Psychiatry","retraction":null,"screen_n_in":null,"score":{"opus":0.3931734814990253,"gpt":0.51069152147912,"spread":0.1175180399800947,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005236588,0.0006391595,0.003028594,0.0002983994,0.00004787175,0.00003609468,0.0005126529,0.000932285,0.00002928505],"category_scores_gemma":[0.0006073421,0.0005570397,0.001141966,0.0008263121,0.0001493654,0.000007094006,0.0003120838,0.000540409,0.000004146169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002362687,"about_ca_system_score_gemma":0.0008129546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008781471,"about_ca_topic_score_gemma":0.000003234936,"domain_scores_codex":[0.9923682,0.002301661,0.003097212,0.00137239,0.0003822078,0.0004783632],"domain_scores_gemma":[0.997087,0.0008993063,0.0009453945,0.0007429473,0.0001408628,0.0001844624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006385705,0.0002096463,0.003032664,0.001708587,0.002372217,0.000004006211,0.00003035111,0.00009992799,0.0001892377,0.00003353668,0.000001865799,0.9923116],"study_design_scores_gemma":[0.004543749,0.002595386,0.1064289,0.009187574,0.00561108,0.0003029927,0.00003530644,0.002505188,0.0004711751,0.001126463,0.8634536,0.003738518],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01642577,0.9436634,0.03855324,0.00002511778,0.0001335149,0.001062101,0.00001458152,0.00001030056,0.0001119768],"genre_scores_gemma":[0.001044913,0.6652192,0.3333199,0.00008303244,0.00002553288,0.00007248118,0.0001313539,0.0000616607,0.00004188233],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9885731,"threshold_uncertainty_score":0.9996881,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4386629705","doi":"10.1016/j.omtm.2023.09.003","title":"Optogenetic targeting of AII amacrine cells restores retinal computations performed by the inner retina","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"European Research Council; Sorbonne Université; Institut National de la Santé et de la Recherche Médicale; H2020 European Research Council; Agence Nationale de la Recherche; Union Nationale des Aveugles et Déficients Visuels; Alliance Nationale pour les Sciences de la Vie et de la Santé; Foundation Fighting Blindness; Retina France; AFM-Téléthon; Centre National de la Recherche Scientifique","keywords":"Optogenetics; Retina; Retinal; Neuroscience; Biology; Amacrine cell; Intrinsically photosensitive retinal ganglion cells; Retinal degeneration; Opsin; Ganglion; Cell biology; Retinal ganglion cell; Rhodopsin","retraction":null,"screen_n_in":null,"score":{"opus":0.1474530964793837,"gpt":0.4780819176994686,"spread":0.3306288212200849,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006332363,0.0002902331,0.0004483319,0.000159478,0.0004011814,0.00006818576,0.0009868776,0.0001509383,0.0001901615],"category_scores_gemma":[0.002391827,0.0002088692,0.0002295002,0.001177118,0.0005535666,0.00003424434,0.0004004295,0.0005729937,0.00009363165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005434196,"about_ca_system_score_gemma":0.000296189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207943,"about_ca_topic_score_gemma":8.903531e-7,"domain_scores_codex":[0.9928278,0.003529719,0.001254542,0.0007605813,0.0009569339,0.0006704652],"domain_scores_gemma":[0.9954616,0.003292718,0.0002819349,0.0005414605,0.0001935261,0.0002287797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001441497,0.0001450807,0.0008439267,0.00001840716,0.00003667266,0.00001365203,0.0005769624,0.0001888608,0.8847593,0.00005573265,0.001353823,0.1118634],"study_design_scores_gemma":[0.0006782518,0.0002284895,0.004734348,0.0000255276,0.000008108406,0.000002765616,0.0000850002,0.001732748,0.9267347,0.0004362804,0.06508504,0.0002487226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731679,0.0005004583,0.02383375,0.0007128742,0.0005268342,0.00070232,0.00001380698,0.00009050602,0.0004515304],"genre_scores_gemma":[0.7226396,0.003499864,0.2712024,0.00135992,0.00008932634,0.0002080332,0.00004832639,0.0001054998,0.0008471078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2505283,"threshold_uncertainty_score":0.8517438,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3094893280","doi":"10.1016/j.omtm.2020.10.023","title":"Modulation of the liver immune microenvironment by the adeno-associated virus serotype 8 gene therapy vector","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Canada Research Chairs","keywords":"Immune system; Immunogenicity; Biology; Genetic enhancement; Immunology; Innate immune system; Viral vector; Neutrophil extracellular traps; Vector (molecular biology); Adeno-associated virus; Virology; Inflammation; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.06951906331733744,"gpt":0.3772080062381636,"spread":0.3076889429208262,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002818883,0.0003752529,0.0004575497,0.00002404661,0.0002251786,0.00003414198,0.001067214,0.0003253696,0.0001375273],"category_scores_gemma":[0.0003091664,0.0002422036,0.0004427856,0.0003054563,0.00030882,0.000005581246,0.000334681,0.0004315771,0.00002299863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006276036,"about_ca_system_score_gemma":0.0002632877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001839844,"about_ca_topic_score_gemma":0.00000803917,"domain_scores_codex":[0.9940033,0.003262029,0.000991524,0.0007106626,0.0005785192,0.0004539737],"domain_scores_gemma":[0.9982168,0.0001604362,0.0004180609,0.0009032661,0.0001334938,0.0001679556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001782133,0.0003113438,0.0005140845,0.000004409502,0.0006315286,0.000002010551,0.0002422324,0.0001082068,0.8633181,0.00000302616,0.0002663992,0.1328166],"study_design_scores_gemma":[0.001846847,0.001455013,0.02557959,0.00001009936,0.0000158392,0.000001449199,0.00001645443,0.0001817325,0.936454,0.00003259201,0.03412539,0.0002809736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613721,0.01639045,0.01878581,0.002074472,0.0001856433,0.001128703,0.00001941507,0.00001968234,0.00002367829],"genre_scores_gemma":[0.963689,0.01025221,0.01783848,0.007438228,0.0001288878,0.0001516599,0.0001413853,0.0001170477,0.0002430827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1325356,"threshold_uncertainty_score":0.9876775,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2762831145","doi":"10.1016/j.omtm.2017.10.003","title":"Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Simon Fraser University; University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"BC Cancer Foundation; Genome British Columbia","keywords":"Granzyme; Granzyme B; Perforin; Cell biology; Cytotoxic T cell; Biology; Granzyme A; Chemistry; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.08815676302751622,"gpt":0.431487083930083,"spread":0.3433303209025668,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01015053,0.0005013737,0.001126475,0.0001744505,0.0004916334,0.00009742213,0.001330894,0.0003722047,0.001223711],"category_scores_gemma":[0.0006524487,0.0003371522,0.0006310201,0.0003044931,0.0004470426,0.00006526058,0.0004574801,0.001028615,0.0001402034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301708,"about_ca_system_score_gemma":0.0008667831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000999469,"about_ca_topic_score_gemma":0.000006048543,"domain_scores_codex":[0.9934158,0.002095404,0.001575903,0.0009349735,0.001167636,0.0008102438],"domain_scores_gemma":[0.995204,0.0006802417,0.0005399097,0.002507686,0.0005109694,0.00055722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001180215,0.0005597222,0.001250781,0.00004938163,0.0002130676,0.00006664013,0.0003592717,0.000002714416,0.5751164,0.00001571734,0.00005625305,0.4211298],"study_design_scores_gemma":[0.003998872,0.001046345,0.0162985,0.00008661002,0.00003389869,0.000006737662,0.00004777501,0.0000873453,0.8509248,0.0002987196,0.1268096,0.0003607205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.92944,0.001792919,0.05968371,0.001795481,0.0004477039,0.003405051,0.000004986614,0.0000667983,0.003363408],"genre_scores_gemma":[0.5247766,0.0005489647,0.4633629,0.002105523,0.0001915979,0.000482207,0.00002157624,0.000152307,0.008358265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4207691,"threshold_uncertainty_score":0.999908,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4289260770","doi":"10.1016/j.omtm.2022.07.010","title":"Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Advanced Research Projects Agency; Defense Advanced Research Projects Agency; California Institute of Technology; Cystic Fibrosis Foundation","keywords":"Transgene; Capsid; Genetic enhancement; Lung; Gene delivery; Transduction (biophysics); Computational biology; Biology; Medicine; Virology; Cell biology; Virus; Gene; Pathology; Bioinformatics; Genetics; Internal medicine; Biophysics","retraction":null,"screen_n_in":null,"score":{"opus":0.04294957936080022,"gpt":0.3687108358792644,"spread":0.3257612565184642,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006695261,0.000321799,0.0003598482,0.00006979958,0.0004704369,0.00003483623,0.0008414191,0.0001556927,0.0003016848],"category_scores_gemma":[0.0005003812,0.0002135167,0.0002867533,0.0003582585,0.000271228,0.000004302505,0.0004297654,0.0006043133,0.000008156899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001488461,"about_ca_system_score_gemma":0.0004424687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002279759,"about_ca_topic_score_gemma":0.000007185167,"domain_scores_codex":[0.9914389,0.00588813,0.0008515966,0.0006693814,0.0006413471,0.0005106127],"domain_scores_gemma":[0.9979786,0.0006141422,0.0002797009,0.0008142104,0.0002047877,0.0001085194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004443356,0.0004492516,0.0006749041,0.000008919664,0.0006464564,0.000008723206,0.0003897682,0.0003700937,0.950674,0.00003353024,0.002662825,0.03963815],"study_design_scores_gemma":[0.001217163,0.002513982,0.001962245,0.00001461188,0.00002902357,0.000004194846,0.0003930265,0.0005250569,0.9548355,0.0004517473,0.03762945,0.0004239949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613659,0.01294157,0.02315095,0.001308395,0.000223238,0.0008872881,0.00002895594,0.00003208206,0.00006158711],"genre_scores_gemma":[0.9775729,0.001173594,0.0165175,0.003536855,0.00009622512,0.0006820641,0.0001514987,0.00008720371,0.0001821871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03921416,"threshold_uncertainty_score":0.8706957,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4384283659","doi":"10.1016/j.omtm.2023.07.002","title":"Inducible HEK293 AAV packaging cell lines expressing Rep proteins","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Université Laval; National Research Council Canada","funders":"Fonds de Recherche du Québec - Santé; National Research Council Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"HEK 293 cells; Transfection; Cell culture; Biology; Transduction (biophysics); Plasmid; Titer; Molecular biology; Cell biology; Viral vector; Activator (genetics); Recombinant DNA; Gene; Virus; Virology; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.1353396892443784,"gpt":0.4733861530791912,"spread":0.3380464638348127,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007654297,0.0004808298,0.0005776571,0.0002258042,0.0003125804,0.0001230566,0.0007909892,0.0004704733,0.00009482424],"category_scores_gemma":[0.0006460651,0.0004425203,0.0003701996,0.0007258079,0.0001926054,0.00001056999,0.0005110311,0.0005566327,0.0001690549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004732654,"about_ca_system_score_gemma":0.0006900493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007553493,"about_ca_topic_score_gemma":0.000007921983,"domain_scores_codex":[0.9936521,0.002294803,0.00114969,0.001351067,0.0005989252,0.0009534325],"domain_scores_gemma":[0.9976107,0.0002120064,0.0002655532,0.001305151,0.0002451648,0.0003613843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007886356,0.0001880076,0.0006162364,0.00002303283,0.0001684619,0.00004146589,0.0001418217,0.00006915537,0.7391518,0.000004115238,0.0004749453,0.2583323],"study_design_scores_gemma":[0.001483667,0.0009954135,0.001546173,0.0000449187,0.000009109289,0.000004026549,0.00006503984,0.00009748356,0.8934926,0.0003007846,0.1014366,0.0005241765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9340464,0.002696395,0.06040714,0.0006204217,0.0004311342,0.0009453549,0.000004608313,0.0001630724,0.0006855032],"genre_scores_gemma":[0.2714606,0.004121861,0.7122535,0.004232904,0.000817132,0.0008348213,0.0003729409,0.0003900761,0.005516158],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6625857,"threshold_uncertainty_score":0.9998026,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3113626698","doi":"10.1016/j.omtm.2020.12.012","title":"AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Stichting Blindenhulp; Rotterdamse Stichting Blindenbelangen; Landelijke Stichting voor Blinden en Slechtzienden; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; ZonMw; Stichting MaculaFonds; Stichting Blinden-Penning; Stichting Steunfonds Uitzicht; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Biology; Retinal degeneration; Retinal; Retina; Electroretinography; Cell biology; Photoreceptor cell; Rhodopsin; Molecular biology; Biochemistry; Neuroscience","retraction":null,"screen_n_in":null,"score":{"opus":0.09446519797469939,"gpt":0.4295733912635136,"spread":0.3351081932888142,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002596474,0.0005121383,0.0005957015,0.0001103792,0.0001333147,0.00009858647,0.0006495927,0.0005225018,0.0000358338],"category_scores_gemma":[0.0005508818,0.0004901381,0.0002328424,0.0003638078,0.000162895,0.00002526864,0.0003385563,0.0004955993,0.00002579017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004356384,"about_ca_system_score_gemma":0.000560682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004705765,"about_ca_topic_score_gemma":0.000009972247,"domain_scores_codex":[0.9948992,0.001323626,0.00129626,0.001370952,0.0004581391,0.0006518876],"domain_scores_gemma":[0.9984156,0.00005301118,0.0002671061,0.0006110225,0.0001604548,0.0004928262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001136645,0.0005824731,0.006483863,0.00004219457,0.0001317244,0.00005417191,0.000657863,0.0007621381,0.7695314,0.00005589222,0.000221488,0.2203401],"study_design_scores_gemma":[0.004213234,0.001240931,0.00559658,0.00006073934,0.000009024645,0.000002627002,0.0001103646,0.003390975,0.9495273,0.000538677,0.03417432,0.001135196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8333372,0.000540319,0.1633346,0.001003934,0.0001294626,0.0009567025,0.000004763232,0.00005572194,0.0006372679],"genre_scores_gemma":[0.4268341,0.001645604,0.5609628,0.009498009,0.00009831512,0.0002416815,0.0002727629,0.0001171842,0.0003295082],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4065031,"threshold_uncertainty_score":0.999755,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2954536666","doi":"10.1016/j.omtm.2019.05.013","title":"Generation of High-Titer Self-Inactivated γ-Retroviral Vector Producer Cells","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Titer; Virology; Viral vector; Vector (molecular biology); Biology; Virus; Genetics; Gene; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.07364101910277951,"gpt":0.4162188386070853,"spread":0.3425778195043058,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003245266,0.0003565737,0.0005458065,0.0001104935,0.00006725373,0.00003463464,0.0004798205,0.000380376,0.0002558559],"category_scores_gemma":[0.0001427265,0.0003141025,0.0002672908,0.0002741207,0.00009393982,0.000009131031,0.0001733014,0.0003109059,0.00009978314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006604062,"about_ca_system_score_gemma":0.0005191903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009831966,"about_ca_topic_score_gemma":0.000005007019,"domain_scores_codex":[0.9952968,0.001824747,0.0009578823,0.000961253,0.0004746955,0.0004846615],"domain_scores_gemma":[0.9981411,0.00009030141,0.0002840327,0.0009877569,0.0003245503,0.0001722843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001550952,0.0004191119,0.0009269669,0.00002045073,0.0005074983,0.000003694303,0.00008283319,0.00006641713,0.9130599,0.00002092542,0.0001704123,0.08317085],"study_design_scores_gemma":[0.001989451,0.002967815,0.003020677,0.00001265861,0.00001407268,0.000001650371,0.00000775167,0.00008588893,0.9649871,0.00004570438,0.02648668,0.0003805398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781767,0.0007315318,0.01911175,0.0001817428,0.0006872755,0.0009502441,0.000005806691,0.00003670312,0.0001182646],"genre_scores_gemma":[0.7486649,0.0004310613,0.2486344,0.0009254121,0.0002426961,0.00008341189,0.0001449631,0.00009128574,0.0007819137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2295226,"threshold_uncertainty_score":0.9999311,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3198457279","doi":"10.1016/j.omtm.2021.09.002","title":"AAV-mediated PEX1 gene augmentation improves visual function in the PEX1-Gly844Asp mouse model for mild Zellweger spectrum disorder","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Université de Montréal; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Waikato Medical Research Foundation; Global Foundation for Peroxisomal Disorders","keywords":"Genetic enhancement; Peroxisomal disorder; Zellweger syndrome; Biology; Retinal; Retinal degeneration; Adeno-associated virus; Medicine; Ophthalmology; Gene; Vector (molecular biology); Genetics; Peroxisome","retraction":null,"screen_n_in":null,"score":{"opus":0.04984800186399824,"gpt":0.4034345776349497,"spread":0.3535865757709515,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002448039,0.0004087847,0.000429822,0.0000899564,0.0001733614,0.00007846866,0.0003329744,0.0004569521,0.00002904071],"category_scores_gemma":[0.0004580864,0.0003302755,0.000310651,0.0003104982,0.00009748478,0.00001520971,0.0001283752,0.0003523029,0.00001010223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006860255,"about_ca_system_score_gemma":0.0005180253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006443478,"about_ca_topic_score_gemma":0.00002323661,"domain_scores_codex":[0.9958351,0.001334669,0.0009920419,0.0009560334,0.0003448302,0.0005373524],"domain_scores_gemma":[0.9987202,0.0002219748,0.0002367397,0.000501575,0.0001791534,0.000140324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007787463,0.0005821976,0.001224049,0.00001508388,0.0003225286,0.000003568119,0.0002492646,0.0003560748,0.9524553,0.00002141652,0.000130541,0.04386128],"study_design_scores_gemma":[0.003042395,0.0004492513,0.001839033,0.000008201348,0.0000319877,0.000003206961,0.0001525733,0.003620716,0.9720259,0.0003432124,0.01801862,0.000464879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6044866,0.0009771863,0.3930737,0.000525525,0.0002693596,0.0006182292,0.00001105757,0.00002150449,0.00001676167],"genre_scores_gemma":[0.6025044,0.002518844,0.380143,0.01024371,0.000334258,0.001095744,0.001919267,0.0001854771,0.00105528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0433964,"threshold_uncertainty_score":0.9999149,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3047430625","doi":"10.1016/j.omtm.2020.08.005","title":"Rapid In-Process Monitoring of Lentiviral Vector Particles by High-Performance Liquid Chromatography","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; National Research Council Canada","funders":"Canada Research Chairs","keywords":"Chromatography; Process (computing); Viral vector; Chemistry; Materials science; Computer science; Biochemistry; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.04810620249247679,"gpt":0.381543067408778,"spread":0.3334368649163012,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007233933,0.0002535874,0.0003974811,0.00004463658,0.00006805382,0.00001950435,0.0003095232,0.0001910983,0.00003038032],"category_scores_gemma":[0.000162214,0.0002303913,0.0001953713,0.0002814546,0.0001113874,0.00001010092,0.0001157054,0.0001788403,0.00000560843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009689098,"about_ca_system_score_gemma":0.0001260696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005037074,"about_ca_topic_score_gemma":2.32167e-7,"domain_scores_codex":[0.9975037,0.0005270204,0.0008421372,0.0005659338,0.0002315042,0.0003296927],"domain_scores_gemma":[0.9991435,0.00004583198,0.0002292151,0.0002891709,0.00008951062,0.0002028068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007874891,0.0003055002,0.03293239,0.00005028931,0.0001683572,0.00000408943,0.0001298349,0.00007345167,0.8733919,0.00000560209,0.000116804,0.09203432],"study_design_scores_gemma":[0.001267727,0.001263543,0.02493861,0.00004940345,0.000009976289,6.796261e-7,0.00003221763,0.00003453834,0.9654885,0.00003786429,0.006595524,0.000281399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851222,0.00400083,0.01010833,0.0001306216,0.0003084344,0.000250711,0.000005490252,0.00002605686,0.00004732012],"genre_scores_gemma":[0.9611784,0.00211309,0.03576965,0.0006687387,0.0001148163,0.00008427966,0.00002675376,0.00003721986,0.000007037524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09209663,"threshold_uncertainty_score":0.9395086,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2521974675","doi":"10.1038/mtm.2016.51","title":"PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of General Medical Sciences; National Eye Institute","keywords":"PAX6; Aniridia; Biology; Retina; Adeno-associated virus; Genetic enhancement; Gene expression; Retinal; Cell biology; Genetics; Gene; Neuroscience; Vector (molecular biology); Recombinant DNA; Transcription factor","retraction":null,"screen_n_in":null,"score":{"opus":0.03744965505592205,"gpt":0.3803904842790558,"spread":0.3429408292231337,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00208359,0.0004007786,0.0004077651,0.00008431574,0.0001164645,0.00004904567,0.0007929232,0.0004120752,0.00006140884],"category_scores_gemma":[0.001245706,0.0002319179,0.0002401333,0.000244518,0.000189832,0.000009925072,0.0002084201,0.0002541272,0.00003855033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003627854,"about_ca_system_score_gemma":0.000240177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002136219,"about_ca_topic_score_gemma":0.00001245445,"domain_scores_codex":[0.9946539,0.002386822,0.001067611,0.0009510742,0.0004295312,0.0005110675],"domain_scores_gemma":[0.9981751,0.0004549567,0.0002724629,0.0007913347,0.0001485191,0.0001576404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006912771,0.0002587595,0.01393829,0.000004511676,0.0001002948,0.00003024233,0.0003985289,6.602783e-7,0.7651534,0.00002948741,0.001133624,0.2182609],"study_design_scores_gemma":[0.003371642,0.0003301663,0.06254791,0.0001024381,0.00001129987,0.000002791331,0.0002238613,0.000003607631,0.8420998,0.0008847567,0.08987004,0.0005516259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9269285,0.0006404185,0.06938677,0.001632514,0.0002568657,0.000593912,0.000005964653,0.00002842605,0.0005266681],"genre_scores_gemma":[0.4732498,0.004642178,0.5144358,0.005897452,0.000177406,0.0003262992,0.0002550138,0.000100785,0.0009152711],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4536787,"threshold_uncertainty_score":0.9457337,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4297199830","doi":"10.1016/j.omtm.2022.09.012","title":"Hypothalamic AAV-BDNF gene therapy improves metabolic function and behavior in the Magel2-null mouse model of Prader-Willi syndrome","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Endocrinology; Internal medicine; Adipokine; Energy homeostasis; Leptin; Transgene; Neurotrophic factors; Genetic enhancement; Medicine; Adeno-associated virus; Obesity; Biology; Gene; Receptor; Vector (molecular biology)","retraction":null,"screen_n_in":null,"score":{"opus":0.06070591502524848,"gpt":0.3556115178513728,"spread":0.2949056028261244,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003718286,0.0003213383,0.000507346,0.0001116378,0.0001742391,0.00003478706,0.0005137055,0.0001811151,0.00002507198],"category_scores_gemma":[0.00009797529,0.0002645779,0.0002429405,0.0002184597,0.0001332176,0.000006800463,0.0003381023,0.0003704098,0.000001219504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001790224,"about_ca_system_score_gemma":0.0001933027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001446538,"about_ca_topic_score_gemma":0.000001882368,"domain_scores_codex":[0.9959653,0.001524642,0.00098803,0.0007372944,0.0003786935,0.0004060662],"domain_scores_gemma":[0.9987636,0.0001032719,0.0003124508,0.0006674756,0.0000643659,0.00008883334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003169371,0.0004052637,0.005616732,0.000007501147,0.0001604704,0.000002441515,0.0001926291,0.0002002201,0.7975551,0.00002696877,0.000004118077,0.1957969],"study_design_scores_gemma":[0.003191482,0.001588409,0.5108097,0.000006199959,0.00007512671,0.0001036841,0.0003045393,0.0005740004,0.473968,0.0005861471,0.0082008,0.0005919008],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562891,0.006284447,0.03617696,0.0001662871,0.0001959299,0.0008423451,0.000009364406,0.00001277778,0.00002279598],"genre_scores_gemma":[0.8356339,0.00239475,0.1600682,0.001156406,0.00002694705,0.0004649242,0.00004582744,0.00005636125,0.0001526977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.505193,"threshold_uncertainty_score":0.9999806,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}