{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":349,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":349,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"query_hash":"8995b24c0e06","filters":{"venue":"Pharmaceutics"}},"results":[{"id":"W2768654546","doi":"10.3390/pharmaceutics9040053","title":"An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery","year":2017,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1344,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chitosan; Drug delivery; Mucoadhesion; Drug; Pharmacology; Drug carrier; Nanotechnology; Chemistry; Medicine; Materials science; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.3861756803024498,"gpt":0.5560050853975379,"spread":0.1698294050950881,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008056368,0.0006896806,0.001991153,0.0003373457,0.0002260641,0.00003722686,0.0009602509,0.0005307832,0.00004373128],"category_scores_gemma":[0.00004342703,0.0006762957,0.0002617943,0.0002665542,0.0002183595,0.0004327262,0.0002836268,0.001313285,0.00006175541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009076982,"about_ca_system_score_gemma":0.0002044421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003446183,"about_ca_topic_score_gemma":0.00004057187,"domain_scores_codex":[0.9959025,0.001009036,0.001364847,0.0007667338,0.000259397,0.000697455],"domain_scores_gemma":[0.9971716,0.0003748139,0.001263018,0.000688457,0.00007215134,0.0004299769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007169694,0.0004354866,0.0006137753,0.0177593,0.0002416629,0.00003701597,0.000487791,0.00009179235,0.005809076,0.0001212155,0.00004278955,0.9742884],"study_design_scores_gemma":[0.001321928,0.00005089866,0.00004108217,0.003108643,0.001301575,0.00006084797,0.00004589105,0.009627907,0.007804922,0.00003544463,0.9758921,0.0007087374],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02072188,0.9753753,0.000007470473,0.00002599041,0.000972258,0.002203015,0.0003917617,0.00006231182,0.0002400257],"genre_scores_gemma":[0.167389,0.8316143,0.00004613826,0.0001228677,0.0002758244,0.0002990855,0.0001368448,0.0000822573,0.00003373348],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9758493,"threshold_uncertainty_score":0.9995688,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2921550223","doi":"10.3390/pharmaceutics11030129","title":"Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals","year":2019,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":879,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Alberta Innovates - Technology Futures","keywords":"Drug delivery; Risk analysis (engineering); Oral route; Computer science; Drug administration; Delivery system; Medicine; Pharmacology; Nanotechnology","retraction":null,"screen_n_in":null,"score":{"opus":0.4559354999229223,"gpt":0.5393409093546985,"spread":0.08340540943177621,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.003587381,0.001591297,0.004211979,0.0008231142,0.000222384,0.0001034192,0.001027424,0.001536382,0.00009521948],"category_scores_gemma":[0.0001262029,0.001484699,0.0005526051,0.000586912,0.0005076366,0.0003478619,0.0005257742,0.002912256,0.0004795494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007622258,"about_ca_system_score_gemma":0.000556201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005254944,"about_ca_topic_score_gemma":0.0000164095,"domain_scores_codex":[0.9908897,0.002490818,0.002279498,0.001818984,0.0004905848,0.002030427],"domain_scores_gemma":[0.9939497,0.002968937,0.001101916,0.0007524558,0.0003713531,0.0008556767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002455733,0.0004182686,0.00006713419,0.06100213,0.0008519309,0.0001001077,0.0003806474,0.00006432076,0.000003064874,0.0006516684,0.001372074,0.9348431],"study_design_scores_gemma":[0.003314992,0.00008938133,0.000002488644,0.004444012,0.003271043,0.0002032546,0.0001940479,0.005362912,0.00002793818,0.00004541848,0.9815704,0.001474094],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005852258,0.9795049,0.0000158199,0.0002728396,0.007956651,0.01010338,0.0007940992,0.0002752884,0.001018462],"genre_scores_gemma":[0.0002041251,0.9941834,0.0002089539,0.0003866975,0.0008694766,0.002584286,0.0002649957,0.0003410723,0.0009569481],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9801983,"threshold_uncertainty_score":0.9997599,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3206760826","doi":"10.3390/pharmaceutics13101686","title":"Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":351,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chitosan; Drug delivery; Biodistribution; Bioavailability; Chemistry; Nanotechnology; Nanoparticle; In vivo; Systemic administration; Drug carrier; Pharmacology; Biophysics; In vitro; Materials science; Biochemistry; Medicine; Biotechnology","retraction":null,"screen_n_in":null,"score":{"opus":0.3978350047948026,"gpt":0.5457415382064116,"spread":0.147906533411609,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001079701,0.0009042609,0.00182811,0.000129383,0.001119571,0.00007351888,0.001259776,0.0007803001,0.0006090697],"category_scores_gemma":[0.0002428438,0.0006296737,0.001077132,0.0005736221,0.0006051761,0.0001103499,0.0008897581,0.001753699,0.0004493286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995992,"about_ca_system_score_gemma":0.0004052281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003735148,"about_ca_topic_score_gemma":0.00001647071,"domain_scores_codex":[0.9943233,0.001870884,0.001373006,0.00104207,0.0001882453,0.001202541],"domain_scores_gemma":[0.9932927,0.004382101,0.0007787147,0.0008814607,0.0001971055,0.0004679111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006590011,0.0002960277,0.00008122697,0.00273338,0.001154563,0.00001361774,0.000240483,0.0001504028,0.003763708,0.0005780584,0.02575356,0.9651691],"study_design_scores_gemma":[0.0006715624,0.00003335567,0.000001762137,0.0006216784,0.002435272,0.0002073473,0.00008706119,0.0001548671,0.007690567,0.00006628622,0.9873272,0.0007030031],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001034956,0.9879367,0.0001739432,0.001020563,0.003334557,0.003557161,0.002144204,0.000240034,0.0005579233],"genre_scores_gemma":[0.002074207,0.9909981,0.0001999993,0.001287062,0.001030964,0.002093316,0.0006743419,0.00014708,0.001494907],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9644661,"threshold_uncertainty_score":0.9996154,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4379179468","doi":"10.3390/pharmaceutics15061630","title":"Biomarkers as Biomedical Bioindicators: Approaches and Techniques for the Detection, Analysis, and Validation of Novel Biomarkers of Diseases","year":2023,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":338,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Foothills Medical Centre; University of Calgary","funders":"","keywords":"Biomarker; Computational biology; Biomarker discovery; Metabolomics; Bioinformatics; Epigenetics; Medicine; Computer science; Proteomics; Biology; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.1839054498954598,"gpt":0.4405307620192335,"spread":0.2566253121237737,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001396427,0.0002681117,0.0008056779,0.00103146,0.0001054519,0.00007330866,0.0005889882,0.0001331799,9.850335e-7],"category_scores_gemma":[0.000369839,0.0001920175,0.0003597124,0.002817862,0.0004545157,0.0001452288,0.0004049134,0.0001162221,3.301186e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004085384,"about_ca_system_score_gemma":0.0002500285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000175961,"about_ca_topic_score_gemma":0.000001061588,"domain_scores_codex":[0.9979799,0.0002629112,0.0007013421,0.0004830447,0.0003935332,0.000179221],"domain_scores_gemma":[0.9953288,0.003391672,0.0007051448,0.0003635769,0.00009239175,0.0001184157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000111226,0.00008696118,0.00003078812,0.00547096,0.003597378,3.796105e-7,0.00005408371,0.00001330127,0.00001988307,0.0005536147,0.00001917203,0.9901423],"study_design_scores_gemma":[0.001102936,0.0003114535,0.0003371553,0.003043196,0.03673611,0.00006584345,0.0001279174,0.4494168,0.008267917,0.002923181,0.4964333,0.001234208],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002450795,0.5024655,0.4963591,0.00006987578,0.00009726428,0.0007044732,0.0002221013,0.00005398659,0.000003161024],"genre_scores_gemma":[0.0008772784,0.9543223,0.04440083,0.00001359073,0.00005585257,0.0001935534,0.0001045529,0.00002861039,0.000003468983],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9889082,"threshold_uncertainty_score":0.7830247,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3103321439","doi":"10.3390/pharmaceutics12111095","title":"Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":302,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Precision Nanosystems (Canada)","funders":"Engineering and Physical Sciences Research Council; Cancer Research UK","keywords":"Dispersity; Microfluidics; Chemistry; Nanoparticle; Nanotechnology; Buffer (optical fiber); Payload (computing); Nucleic acid; Particle size; Chromatography; Materials science; Computer science; Biochemistry; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.1552105268611953,"gpt":0.3512033802500744,"spread":0.1959928533888791,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007429918,0.00006767974,0.00006268746,0.000007401383,0.0001163578,0.00001303378,0.00008347652,0.00002919874,0.0000156957],"category_scores_gemma":[0.00004198004,0.00005429584,0.00004163851,0.00001799744,0.0000363826,0.000002250109,0.00006015,0.00003498866,0.000002450556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004581078,"about_ca_system_score_gemma":0.00008452593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.608453e-7,"about_ca_topic_score_gemma":0.000002186672,"domain_scores_codex":[0.9995427,0.00001265617,0.000174765,0.0001101852,0.00004906554,0.0001106964],"domain_scores_gemma":[0.9997406,0.00003357861,0.00004876426,0.00007978165,0.0000558759,0.00004138679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003349227,0.00001235986,0.0001463246,0.00002168735,0.00006310891,1.656288e-7,0.0004514973,0.0004011175,0.9962599,0.00000888316,0.0006755539,0.001925931],"study_design_scores_gemma":[0.0002292645,0.00002935359,0.00003639863,0.000004030982,0.00003221325,0.000002071399,0.0001933941,0.002183719,0.9575119,0.00001259221,0.03969781,0.00006724587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849473,0.0008410328,0.01341885,0.0004913644,0.00009928759,0.0001582031,0.0000155257,0.000004638276,0.00002384705],"genre_scores_gemma":[0.9914339,0.0001244643,0.007216509,0.001035695,0.0001541305,0.000008437059,0.000006939361,0.000008652389,0.000011254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03902225,"threshold_uncertainty_score":0.221412,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3083556913","doi":"10.3390/pharmaceutics12090846","title":"Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":239,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Polypharmacy; Mechanism (biology); Drug; Pharmacology; Drug interaction; Mechanism of action; Medicine; Chemistry; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.381747708704486,"gpt":0.548695033973512,"spread":0.166947325269026,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00480182,0.001222166,0.00333832,0.001179055,0.0003199809,0.00008272511,0.0005837412,0.0006894074,0.0009646508],"category_scores_gemma":[0.0008683349,0.001298252,0.001188117,0.002167664,0.0002495663,0.0003680402,0.000571079,0.005105731,0.0005532557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008650714,"about_ca_system_score_gemma":0.001258023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002190627,"about_ca_topic_score_gemma":0.00003758185,"domain_scores_codex":[0.9883813,0.004542279,0.003770266,0.00139805,0.0008036111,0.0011045],"domain_scores_gemma":[0.9918139,0.004019035,0.001943664,0.0005849513,0.0003819028,0.001256569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001697057,0.005848575,0.000007068099,0.01899147,0.002620629,0.00487354,0.001971266,0.001419291,0.003740826,0.09683242,0.01693651,0.8450614],"study_design_scores_gemma":[0.002978947,0.0000874637,5.023376e-7,0.002554986,0.004944718,0.0002452421,0.0003814172,0.002860634,0.01364589,0.0057853,0.9653845,0.001130388],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001725216,0.9236642,0.04742302,0.00498887,0.01121895,0.0055711,0.001732449,0.0003342055,0.004894684],"genre_scores_gemma":[0.01633716,0.9664312,0.004487909,0.01036733,0.001071739,0.0004906989,0.0003893377,0.0002695162,0.000155081],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.948448,"threshold_uncertainty_score":0.9999486,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2034139519","doi":"10.3390/pharmaceutics5030498","title":"Advances in Lipid Nanoparticles for siRNA Delivery","year":2013,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":222,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Alnylam Pharmaceuticals","keywords":"Small interfering RNA; Gene silencing; RNA interference; Drug delivery; RNA; Cytoplasm; Computational biology; Chemistry; Nanotechnology; Cell biology; Gene; Biology; Biochemistry; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.02593901748402649,"gpt":0.3188863563269368,"spread":0.2929473388429104,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007430785,0.0001028149,0.0000879338,0.00003127012,0.00003433584,0.00002232843,0.0001454607,0.00005734168,0.00004703769],"category_scores_gemma":[0.00002895282,0.00009820851,0.00005333704,0.0000508431,0.00003724941,0.000015018,0.00005151716,0.00005110795,0.00006063917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008966752,"about_ca_system_score_gemma":0.00002501456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009439384,"about_ca_topic_score_gemma":0.00002712908,"domain_scores_codex":[0.9993169,0.00002026623,0.0001607466,0.0001981931,0.00005738272,0.0002464899],"domain_scores_gemma":[0.9996675,0.00001716012,0.00003685769,0.0001339742,0.00008226861,0.00006220529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005812045,0.00005297352,0.003064319,0.00002102271,0.00001015098,6.286837e-7,0.00003041383,0.0001595813,0.9396352,0.00002227198,0.002109797,0.05483558],"study_design_scores_gemma":[0.000553571,0.0001256492,0.000411894,0.000009626973,0.000009040593,0.000002570856,0.00007902794,0.001283224,0.8428143,0.0001870486,0.1543822,0.0001417644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944078,0.003814003,0.0003094783,0.0001918616,0.0002268555,0.0002754289,0.000009916972,0.000009711409,0.0007549521],"genre_scores_gemma":[0.9936021,0.004406769,0.0005184919,0.0008451862,0.0002175819,0.0001086031,0.00002506249,0.0000135606,0.0002626644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1522724,"threshold_uncertainty_score":0.4004827,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3008589136","doi":"10.3390/pharmaceutics12020171","title":"Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Ontario Ministry of Research and Innovation; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","keywords":"Drug delivery; Antiviral drug; Drug; Nanotechnology; Antiviral therapy; Liposome; Targeted drug delivery; Pharmacology; Medicine; Virology; Virus; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.09679727772007883,"gpt":0.3960214273274908,"spread":0.2992241496074119,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003630169,0.0005876043,0.001205466,0.00003543322,0.0001539117,0.00004828344,0.000616548,0.0005046875,0.00004334843],"category_scores_gemma":[0.00006534015,0.0004880735,0.0008447813,0.0001029199,0.0001455885,0.000005986691,0.0001428451,0.000184332,0.00005148421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003229159,"about_ca_system_score_gemma":0.0003917514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002572354,"about_ca_topic_score_gemma":0.000002675725,"domain_scores_codex":[0.9976245,0.0001844625,0.0006622194,0.0007716867,0.0001186815,0.0006385005],"domain_scores_gemma":[0.9990094,0.00005010498,0.0002658271,0.0003146119,0.00009802659,0.0002620561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005176006,0.00008077632,0.00005414002,0.006331122,0.00117656,0.00008198783,0.0001818709,0.000001538747,0.08983254,0.000008881626,0.005713335,0.8960196],"study_design_scores_gemma":[0.0004162981,0.0001979122,5.248653e-7,0.0003382245,0.0004508426,0.0000219597,0.0000335667,0.000006477781,0.05928599,0.000005693978,0.9386803,0.0005622184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01447394,0.9809418,0.0004156179,0.00002090133,0.0007895113,0.001155051,0.002101918,0.0000428569,0.0000584519],"genre_scores_gemma":[0.008920643,0.9870676,0.0003195027,0.0004124382,0.0008979649,0.0002296896,0.001859404,0.0000829941,0.0002096969],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9329669,"threshold_uncertainty_score":0.9997571,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3115246370","doi":"10.3390/pharmaceutics13010049","title":"Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":179,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Alberta Health Services; University of Alberta","funders":"","keywords":"Particle therapy; Alpha particle; Medical physics; Radionuclide therapy; Medicine; Radiation therapy; Nuclear medicine; Nuclear physics; Physics; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.09972746975527896,"gpt":0.4321831569109559,"spread":0.332455687155677,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001970857,0.0005356501,0.001351845,0.0001019375,0.0001139106,0.00004063037,0.0002537131,0.0003136453,0.00007991722],"category_scores_gemma":[0.0000554951,0.0004827861,0.0002414366,0.0009718612,0.0003203625,0.00005187737,0.00007455562,0.001168226,0.00004194559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809775,"about_ca_system_score_gemma":0.0003567618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.136727e-7,"about_ca_topic_score_gemma":5.994973e-8,"domain_scores_codex":[0.9976425,0.00006722936,0.0007614398,0.0008693057,0.0002638797,0.0003956371],"domain_scores_gemma":[0.9985518,0.00008478325,0.0002444414,0.0005094473,0.00008475174,0.0005247395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003384912,0.0003088177,0.000104482,0.01408411,0.0002351908,0.00003657411,0.00003812978,2.771568e-7,0.0002189206,0.00004214106,0.001004818,0.9838927],"study_design_scores_gemma":[0.0008150255,0.00001772928,0.000007647826,0.001273505,0.0009530574,0.00058947,0.00001062922,0.0000810366,0.003216358,0.00002927716,0.9926068,0.0003995265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003181501,0.9943433,0.00003534997,0.001589919,0.00008067494,0.003163259,0.00006553165,0.0001760257,0.0005140974],"genre_scores_gemma":[0.0003048929,0.9942538,0.0007151101,0.0002656049,0.001263265,0.002305501,0.0004074752,0.0001007396,0.0003835781],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9916019,"threshold_uncertainty_score":0.9997624,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2758156076","doi":"10.3390/pharmaceutics9040041","title":"Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models","year":2017,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":178,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Physiologically based pharmacokinetic modelling; Pharmacokinetics; Bioavailability; Drug; Pharmacology; Absorption (acoustics); Chemistry; Medicine; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.5386076667550478,"gpt":0.5450790665669797,"spread":0.006471399811931899,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.003759144,0.001932732,0.004765994,0.00038318,0.001161574,0.0001710137,0.002709082,0.001347182,0.002299912],"category_scores_gemma":[0.0003198874,0.001626131,0.002006195,0.0004942677,0.0006538455,0.0003643821,0.000473577,0.005221046,0.003054652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004370676,"about_ca_system_score_gemma":0.0007861015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000193506,"about_ca_topic_score_gemma":0.000004626904,"domain_scores_codex":[0.9891762,0.003967669,0.002512765,0.001768474,0.0009263579,0.00164853],"domain_scores_gemma":[0.9925436,0.001859912,0.002539269,0.001654275,0.0003643605,0.001038621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001941706,0.0009684702,0.00001272985,0.1014033,0.001166527,0.0002711212,0.00007675628,0.001600652,0.000009078365,0.000134291,0.05394782,0.8402151],"study_design_scores_gemma":[0.001726118,0.0001257772,7.495972e-7,0.03316142,0.007184849,0.00008090241,0.000007407543,0.01809474,0.00004310122,0.00008960661,0.9380229,0.001462396],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002950276,0.9713761,0.00003875462,0.0005798623,0.006217101,0.004640439,0.001067588,0.000617469,0.01543317],"genre_scores_gemma":[0.000525242,0.980844,0.0001015736,0.01079903,0.00203526,0.00100721,0.000816774,0.0002370096,0.003633879],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8840751,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2953718791","doi":"10.3390/pharmaceutics11070302","title":"Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives","year":2019,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":168,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Medicine; Drug delivery; Cancer; Malignancy; Head and neck cancer; Disease; Intensive care medicine; Head and neck squamous-cell carcinoma; Radiation therapy; Drug; Chronotherapy (sleep phase); Biopharmaceutical; Oncology; Bioinformatics; Pharmacology; Internal medicine; Circadian rhythm; Biotechnology","retraction":null,"screen_n_in":null,"score":{"opus":0.08307672444134975,"gpt":0.3833786094744092,"spread":0.3003018850330594,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001134285,0.0007443599,0.002277872,0.0001748042,0.00007596795,0.0001126852,0.0001673389,0.0001957707,0.00002451343],"category_scores_gemma":[0.000005164395,0.0005604808,0.0004857902,0.0001502033,0.00004937474,0.0001244689,0.00002876954,0.0003566931,0.00001693558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001518429,"about_ca_system_score_gemma":0.0003215997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002488165,"about_ca_topic_score_gemma":0.00001246998,"domain_scores_codex":[0.9982001,0.00004185248,0.0005316032,0.0003772819,0.0001806086,0.0006685376],"domain_scores_gemma":[0.9989334,0.0002823869,0.000192353,0.0002673022,0.0001083219,0.0002162691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008781882,0.00004189419,0.000005317165,0.03223068,0.002234782,0.000002180714,0.000590077,0.000340742,0.000003829167,0.00008720999,0.0007367109,0.9636388],"study_design_scores_gemma":[0.005058319,0.00004053344,1.394963e-7,0.001747214,0.00562997,0.00000503036,0.0002046619,0.00630901,0.000006772913,0.000005486046,0.9804158,0.0005771171],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006220633,0.9857179,0.00009184189,0.000006112965,0.007256947,0.004527745,0.002066012,0.0002042977,0.00006693637],"genre_scores_gemma":[0.000067222,0.9962611,0.00004866838,0.000005671035,0.001761284,0.001244788,0.0001421689,0.0002089761,0.0002600897],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979679,"threshold_uncertainty_score":0.9996847,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3007796728","doi":"10.3390/pharmaceutics12020183","title":"Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"Gene delivery; Context (archaeology); Computer science; Set (abstract data type); Underpinning; Computational biology; Vector (molecular biology); Transfection; Biology; Risk analysis (engineering); Data science; Gene; Medicine; Genetics; Engineering","retraction":null,"screen_n_in":null,"score":{"opus":0.05985772415039132,"gpt":0.3666277781989967,"spread":0.3067700540486054,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002008697,0.0004766988,0.0007542616,0.00007525746,0.00006284044,0.00005685475,0.0008813416,0.0003105933,0.0002434964],"category_scores_gemma":[0.00002336731,0.0003656737,0.0004120079,0.0002190847,0.00005035322,0.000003963902,0.0005318664,0.0004569115,0.003781167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005418565,"about_ca_system_score_gemma":0.0002946141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007249143,"about_ca_topic_score_gemma":0.000004086803,"domain_scores_codex":[0.9981536,0.000118664,0.0004838196,0.0006180251,0.0001902327,0.0004357049],"domain_scores_gemma":[0.9990437,0.00002558331,0.0001422807,0.0005270056,0.00007231139,0.0001891441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001350985,0.00005804463,0.000003052827,0.001043377,0.0004557626,0.0000688705,0.0001627193,0.0000122275,0.05038917,2.495354e-7,0.2781786,0.6694928],"study_design_scores_gemma":[0.0002008425,0.00009229031,4.274403e-7,0.0002899783,0.0003236932,0.00002876904,0.000009821179,0.0001847712,0.03670446,0.000001393418,0.9617527,0.0004108251],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005728421,0.9954883,0.00003136609,0.001263279,0.0002600446,0.0008219801,0.0006346498,0.00001187706,0.0009156548],"genre_scores_gemma":[0.0003566676,0.985428,0.0001077007,0.009912574,0.000667515,0.00009415024,0.0006367759,0.000069409,0.002727201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6835741,"threshold_uncertainty_score":0.9998795,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2754662782","doi":"10.3390/pharmaceutics9030036","title":"Augmented Renal Clearance in Critical Illness: An Important Consideration in Drug Dosing","year":2017,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Dosing; Cochrane Library; MEDLINE; Intensive care medicine; Renal function; Observational study; Critically ill; Emergency medicine; Internal medicine; Meta-analysis","retraction":null,"screen_n_in":null,"score":{"opus":0.2794798512329839,"gpt":0.5430575493466337,"spread":0.2635776981136498,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008803732,0.0004602695,0.001562689,0.0003771037,0.0001349346,0.0001200707,0.0002357854,0.0002503555,0.00008902995],"category_scores_gemma":[0.000380298,0.0004212483,0.0002072851,0.000223311,0.0002164366,0.0001531717,0.00009660942,0.001367939,0.00003284343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199499,"about_ca_system_score_gemma":0.0004866212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003968305,"about_ca_topic_score_gemma":0.00005347528,"domain_scores_codex":[0.99703,0.0002312735,0.0012394,0.000582839,0.0003596713,0.0005568737],"domain_scores_gemma":[0.9985157,0.0002099533,0.0003438197,0.0005221746,0.0001026529,0.0003056696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001956908,0.0009206229,0.000340169,0.0144258,0.0001063335,0.00203392,0.0003358931,0.00001444776,0.00009317046,0.0006338601,0.0004348881,0.9804652],"study_design_scores_gemma":[0.002081299,0.00005172056,0.0001458162,0.01750161,0.001014718,0.0002373118,0.00003281118,0.007595666,0.0001885438,0.00005482966,0.9705431,0.0005525335],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009543287,0.9959208,0.00003652678,0.0004036864,0.0006765667,0.001103194,0.00003580187,0.00004692213,0.0008221975],"genre_scores_gemma":[0.03565238,0.962867,0.0003887774,0.0003258416,0.0004016356,0.00001564349,0.0001560022,0.00008848316,0.0001042701],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9799126,"threshold_uncertainty_score":0.9998239,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3043470457","doi":"10.3390/pharmaceutics12070672","title":"Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":143,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Genentech","keywords":"Physiologically based pharmacokinetic modelling; Bioavailability; Pharmacokinetics; Drug; Gastric emptying; Pharmacology; Biopharmaceutics; Biopharmaceutics Classification System; Population; Chemistry; Medicine; Internal medicine; Biological activity; Stomach; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.179044520357849,"gpt":0.460061158863001,"spread":0.281016638505152,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001086879,0.001226704,0.002909946,0.0003346673,0.0002808518,0.00004168633,0.001103317,0.001031195,0.0002697609],"category_scores_gemma":[0.0001938561,0.001104064,0.001142757,0.0008893258,0.0002620953,0.0001375116,0.0002484972,0.003020701,0.001123637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003453618,"about_ca_system_score_gemma":0.0005618726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001090404,"about_ca_topic_score_gemma":0.000001139451,"domain_scores_codex":[0.9928898,0.002537668,0.001751726,0.001276961,0.000691534,0.0008523149],"domain_scores_gemma":[0.9954631,0.001884736,0.001172612,0.0006113346,0.0003027843,0.0005654054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001645471,0.001096571,0.000008044948,0.03305876,0.001873299,0.00006745875,0.0002660952,0.02452086,0.0004082949,0.0004978417,0.001224917,0.9353324],"study_design_scores_gemma":[0.001992039,0.0008895451,3.698625e-7,0.001607569,0.00384358,0.00001888624,0.00001747402,0.2537058,0.00141098,0.0001735111,0.735582,0.0007582571],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001038033,0.9833867,0.003743083,0.0002205578,0.002380048,0.006158278,0.0009317042,0.0005155168,0.001626094],"genre_scores_gemma":[0.09614933,0.8974451,0.0001713604,0.002769463,0.001324565,0.001325836,0.0005600323,0.0001649051,0.00008941995],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9345741,"threshold_uncertainty_score":0.9996541,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2037609941","doi":"10.3390/pharmaceutics5030457","title":"Bioavailability of Polyphenol Liposomes: A Challenge Ahead","year":2013,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Phytochemicals and Antioxidant Activities","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Institute of Cancer Research; National Cancer Institute; Institut National Du Cancer; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Institut de France","keywords":"Bioavailability; Polyphenol; Liposome; Pharmacology; Pharmacokinetics; Chemistry; Medicine; Biochemistry; Antioxidant","retraction":null,"screen_n_in":null,"score":{"opus":0.05166051867569835,"gpt":0.3317534440707918,"spread":0.2800929253950935,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007734062,0.0001188364,0.0002685115,0.00004909335,0.00002341664,0.000007107784,0.00007456647,0.00005806903,0.0007801302],"category_scores_gemma":[0.00004681726,0.00009774468,0.00009511146,0.0001107372,0.0001549892,0.0001007846,0.00004449611,0.0001696853,0.000111549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002497962,"about_ca_system_score_gemma":0.0000460225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003338641,"about_ca_topic_score_gemma":5.950311e-7,"domain_scores_codex":[0.9991903,0.00001881849,0.0002298537,0.0001582921,0.0001828483,0.0002198933],"domain_scores_gemma":[0.9993888,0.00006531782,0.00006989804,0.0002269417,0.0001114313,0.000137628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005135198,0.0006755965,0.007516802,0.0004979803,0.00008370798,0.000003281974,0.0003661599,2.02436e-7,0.9729003,0.0002219651,0.000919402,0.01676326],"study_design_scores_gemma":[0.001150012,0.0001453306,0.006018735,0.0001041879,0.000102088,0.00001717406,0.0002616433,0.0007171467,0.9778608,0.0007704477,0.01270125,0.0001511962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840456,0.001791491,0.00002160304,0.002152578,0.00009112613,0.0003759129,0.00001341283,0.00006242909,0.01144581],"genre_scores_gemma":[0.9980302,0.000638635,0.0004353758,0.0003336041,0.0001420194,0.00002366289,0.000004335925,0.00001556333,0.0003766197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01661207,"threshold_uncertainty_score":0.8541878,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4309308048","doi":"10.3390/pharmaceutics14112463","title":"Precision Nanotoxicology in Drug Development: Current Trends and Challenges in Safety and Toxicity Implications of Customized Multifunctional Nanocarriers for Drug-Delivery Applications","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":122,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Nanocarriers; Nanotoxicology; Commercialization; Nanotechnology; Drug delivery; Risk analysis (engineering); Drug; Biochemical engineering; Medicine; Pharmacology; Business; Engineering; Nanoparticle; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.1611880571253872,"gpt":0.3918540635990325,"spread":0.2306660064736452,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001238281,0.0002673328,0.0008555619,0.0004009258,0.0002341435,0.00001966711,0.0002822989,0.00009038734,0.0001075238],"category_scores_gemma":[0.00005294781,0.0002572641,0.00009544458,0.0004453351,0.0001436358,0.00008138898,0.0002387495,0.0002076514,0.000003339278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573349,"about_ca_system_score_gemma":0.0002768695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006882785,"about_ca_topic_score_gemma":0.0001019005,"domain_scores_codex":[0.9976594,0.000262763,0.0009986042,0.0006084983,0.0001620453,0.0003086464],"domain_scores_gemma":[0.997928,0.001209165,0.0004282832,0.0002700085,0.00004806869,0.0001164702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004428391,0.0002892905,0.0000216987,0.001947895,0.00001449945,9.536014e-8,0.0002988917,0.000007289452,0.002582985,0.0008689708,0.00003067186,0.9938934],"study_design_scores_gemma":[0.0008211844,0.000007375474,0.0001153999,0.0003472723,0.0001455617,0.000004178202,0.0000677349,0.0000959219,0.003299765,0.0001562518,0.9946992,0.0002401965],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002912237,0.9939023,0.000155716,0.0002627228,0.000130125,0.001956399,0.000577349,0.00002670602,0.00007648421],"genre_scores_gemma":[0.002931236,0.9900103,0.001525593,0.00001331221,0.00002974736,0.005325051,0.0001082494,0.00002771068,0.00002886431],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946685,"threshold_uncertainty_score":0.999988,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3114158415","doi":"10.3390/pharmaceutics13010015","title":"Focused Ultrasound and Microbubbles-Mediated Drug Delivery to Brain Tumor","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":114,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Microbubbles; Drug delivery; Medicine; Blood–brain barrier; Brain tumor; Drug; Central nervous system; Focused ultrasound; Neuroscience; Ultrasound; Pharmacology; Pathology; Internal medicine; Psychology; Radiology; Chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.04027625265706507,"gpt":0.3051541106423859,"spread":0.2648778579853208,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001144166,0.000491158,0.0009218595,0.0001348415,0.0000859855,0.0001012651,0.0003328518,0.0001149932,0.00007801592],"category_scores_gemma":[0.00005808042,0.0004776056,0.0001744708,0.0004864277,0.00004167951,0.0000565109,0.00005848203,0.0005583485,0.0006745228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001202965,"about_ca_system_score_gemma":0.00009516356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005159593,"about_ca_topic_score_gemma":0.00000956421,"domain_scores_codex":[0.9985918,0.00005322513,0.000433713,0.0003700188,0.0001364883,0.000414726],"domain_scores_gemma":[0.9984083,0.000792773,0.00006331344,0.0002620726,0.00003023114,0.0004432709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003233369,0.00003680558,0.00000697564,0.009545024,0.0004416174,0.0000307277,0.0004501742,0.00003439601,0.002921875,0.00003078297,0.03009353,0.9564049],"study_design_scores_gemma":[0.0001869615,0.000006006239,0.000001121786,0.0006556,0.0005360165,0.00007345532,0.00001237896,0.0001856836,0.00009487759,0.000009804468,0.9977245,0.0005136166],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002249816,0.9968365,0.0001523635,0.0001556382,0.0002021707,0.000910804,0.000586123,0.0004860263,0.0004454376],"genre_scores_gemma":[0.0001675165,0.9972084,0.0008383036,0.0008454142,0.0002872402,0.0001682449,0.0002145254,0.0001768511,0.00009355196],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9676309,"threshold_uncertainty_score":0.9997675,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4384339055","doi":"10.3390/pharmaceutics15071944","title":"Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles","year":2023,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":114,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"University of Zabol","keywords":"Solid lipid nanoparticle; Bioavailability; Nanocarriers; Liposome; Drug delivery; Chemistry; Nanotechnology; Pharmacology; Materials science; Biochemistry; Medicine; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.2780077435241874,"gpt":0.4994662847388794,"spread":0.2214585412146919,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001452626,0.001349781,0.002580017,0.000588488,0.0008804801,0.0001725422,0.0007265516,0.001293977,0.00008357213],"category_scores_gemma":[0.0002114363,0.001296536,0.000491466,0.0005815518,0.0006905309,0.0002844236,0.0003983679,0.001783792,0.0002005479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695083,"about_ca_system_score_gemma":0.0004973483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001686741,"about_ca_topic_score_gemma":0.00000914825,"domain_scores_codex":[0.9937544,0.001112434,0.001802644,0.001384724,0.0004018968,0.001543899],"domain_scores_gemma":[0.9938146,0.003776728,0.0007231231,0.0005667534,0.0002468352,0.0008719595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003250014,0.0004710082,0.00003681309,0.06558452,0.002157851,0.0001078679,0.0002689041,0.001002054,0.001537205,0.0003745251,0.00652457,0.9216097],"study_design_scores_gemma":[0.002688778,0.0001891295,7.869714e-7,0.004082701,0.005836982,0.00006450657,0.00008552502,0.01980671,0.001660659,0.00004503734,0.9642569,0.001282218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008496277,0.9858077,0.0002962976,0.000168827,0.005154926,0.004767082,0.00233812,0.0005418399,0.00007558801],"genre_scores_gemma":[0.0007001415,0.992941,0.0004285519,0.001048576,0.001429603,0.001706604,0.0004315748,0.0003730831,0.0009408453],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9577324,"threshold_uncertainty_score":0.9999253,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4205824181","doi":"10.3390/pharmaceutics14020224","title":"An Overview of Nanotechnologies for Drug Delivery to the Brain","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":112,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Drug delivery; Drug; Medicine; Nanotechnology; Intensive care medicine; Pharmacology; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.2346062398132686,"gpt":0.4385163700979995,"spread":0.2039101302847309,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00205289,0.0003772805,0.001035252,0.0001785812,0.0002374908,0.00006826685,0.001956883,0.0001118995,0.0005120356],"category_scores_gemma":[0.0003011788,0.0002699509,0.0003685162,0.0006435218,0.0001310181,0.0001334767,0.0006129657,0.0003245623,0.0001411376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081123,"about_ca_system_score_gemma":0.0004065522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002498223,"about_ca_topic_score_gemma":0.00001375984,"domain_scores_codex":[0.9972379,0.0005000557,0.0007367804,0.0005296505,0.0004494925,0.000546143],"domain_scores_gemma":[0.9968504,0.001446514,0.0004386927,0.001056047,0.0000866867,0.0001216215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002734626,0.0001406681,3.85696e-7,0.008752733,0.0000446056,0.000006242231,0.000162797,0.0001410482,0.005717634,0.0003722662,0.00853141,0.9761029],"study_design_scores_gemma":[0.00016996,0.00008350213,3.84773e-8,0.0007111171,0.0005614947,0.000007861139,0.00008441312,0.0001751216,0.02954379,0.00009148765,0.9682644,0.0003068193],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00108506,0.9938769,0.00008636661,0.0006226227,0.0009682992,0.002123465,0.001027249,0.0001963944,0.00001358363],"genre_scores_gemma":[0.0001463709,0.996713,0.001030736,0.001023921,0.0001234969,0.000760784,0.00004645863,0.00007498912,0.00008026804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.975796,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2998468579","doi":"10.3390/pharmaceutics12010030","title":"Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"","keywords":"DNA vaccination; Immune system; Computational biology; Biology; Immunology; Virology; Medicine; Immunization","retraction":null,"screen_n_in":null,"score":{"opus":0.04672788407179804,"gpt":0.3435271141115817,"spread":0.2967992300397836,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001154465,0.0005664972,0.001032419,0.0001444842,0.00005160188,0.00006770669,0.0008080134,0.0005372113,0.000009307395],"category_scores_gemma":[0.0001051663,0.0004940574,0.0003650167,0.0002686595,0.00002169198,0.000003943881,0.000572904,0.000385264,0.0003169304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005675762,"about_ca_system_score_gemma":0.0001897927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004159301,"about_ca_topic_score_gemma":9.914827e-7,"domain_scores_codex":[0.9980778,0.00006366441,0.0005490942,0.000715776,0.0001647112,0.0004289993],"domain_scores_gemma":[0.9988856,0.00002103494,0.0001903541,0.0006216585,0.0001203335,0.0001609902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003366435,0.00003963989,9.107262e-7,0.005583498,0.0006136235,0.0000405468,0.00001503233,0.00003550802,0.02300764,0.00001524794,0.01732856,0.9532861],"study_design_scores_gemma":[0.0001900482,0.0002142906,3.843686e-8,0.0009684913,0.000486303,0.0000442755,0.00004231538,0.0001138489,0.01577599,0.000001479202,0.9816225,0.0005404667],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000101064,0.9963886,0.0005730973,0.00009030035,0.001230394,0.0009563841,0.0003309392,0.0001433875,0.0001858899],"genre_scores_gemma":[0.0009747185,0.9968569,0.0001415024,0.000177998,0.0005908264,0.0002187871,0.000308088,0.00009265725,0.000638581],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9642939,"threshold_uncertainty_score":0.9997511,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3010070151","doi":"10.3390/pharmaceutics12030238","title":"Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"biodegradable polymer synthesis and properties","field":"Materials Science","cited_by":102,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Chitosan; Deferoxamine; Nuclear chemistry; Chemistry; Nanoparticle; Chelation; Solubility; Nanocarriers; Drug carrier; Drug delivery; Inorganic chemistry; Materials science; Organic chemistry; Nanotechnology","retraction":null,"screen_n_in":null,"score":{"opus":0.04744494733506331,"gpt":0.2553971044260288,"spread":0.2079521570909655,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009835135,0.00009923286,0.0001391818,0.00001915442,0.00006714371,0.00003710753,0.00009654225,0.00002964082,0.00003755507],"category_scores_gemma":[0.00001280405,0.00005898779,0.00001326407,0.0001214607,0.00007117037,0.000172859,0.00004130979,0.00006433451,0.000004671984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003964809,"about_ca_system_score_gemma":0.00001492707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001006061,"about_ca_topic_score_gemma":0.000001601217,"domain_scores_codex":[0.9993256,0.00006136037,0.0001829663,0.0001414588,0.0001402104,0.0001484114],"domain_scores_gemma":[0.9997172,0.00003480696,0.0001051512,0.00008534512,0.00001263513,0.0000448559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004076269,0.00001965731,0.00136149,0.00005961073,0.000004771167,5.312264e-7,0.001136964,0.000007077882,0.9915969,0.00002527269,0.000001053141,0.005379044],"study_design_scores_gemma":[0.0003709272,0.00003694688,0.004301029,0.00001259963,0.00003462732,0.000001528563,0.00005572818,0.005397075,0.9894681,0.000004081288,0.0002320538,0.00008533233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995553,0.0009937984,0.0001141874,0.003070184,0.00003576848,0.0001521724,0.00001987972,0.00002255755,0.00003847883],"genre_scores_gemma":[0.9992747,0.00008742115,0.0001405833,0.0004263069,0.00003859215,0.000009391076,0.00000673242,0.00001133033,0.000004906287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005389997,"threshold_uncertainty_score":0.2405452,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2972980127","doi":"10.3390/pharmaceutics11090465","title":"Development and Characterization of the Solvent-Assisted Active Loading Technology (SALT) for Liposomal Loading of Poorly Water-Soluble Compounds","year":2019,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":97,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Solubility; Liposome; Solvent; Chemistry; Drug; Salt (chemistry); Drug delivery; Chromatography; Chemical engineering; Organic chemistry; Pharmacology; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.08682536504695054,"gpt":0.3420115399479574,"spread":0.2551861749010069,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004333415,0.0003056284,0.00100725,0.0002192521,0.000137452,0.00003874663,0.0004600349,0.0002097313,0.00001817837],"category_scores_gemma":[0.00003042417,0.0002097693,0.0001428958,0.0002973439,0.0001730736,0.0001555035,0.0003475596,0.0001937484,0.00001801585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988801,"about_ca_system_score_gemma":0.0003382911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002073769,"about_ca_topic_score_gemma":0.000001206004,"domain_scores_codex":[0.9980346,0.000111204,0.0008409701,0.0003656887,0.0002461722,0.0004013718],"domain_scores_gemma":[0.9984987,0.0001456173,0.0007948074,0.0003129731,0.0001906201,0.00005728298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003686141,0.00008830072,0.00001521613,0.009105942,0.00008444438,7.071293e-7,0.0002340645,0.000001405919,0.8781255,0.00007734961,0.000004206028,0.112226],"study_design_scores_gemma":[0.0004228599,0.00003185073,0.000003453098,0.002316782,0.000528299,0.00001363266,0.0000239742,0.0001406619,0.7953921,0.000007465396,0.2009253,0.0001936104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6329918,0.3598803,0.0005240194,0.0001143589,0.002479675,0.003538032,0.0003231271,0.0001117694,0.00003697884],"genre_scores_gemma":[0.3290706,0.6642541,0.004960154,0.0001094069,0.0002104324,0.0004465483,0.0003413176,0.0002336262,0.000373886],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.3043738,"threshold_uncertainty_score":0.8554143,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2762722794","doi":"10.3390/pharmaceutics9040043","title":"Revolutionizing Therapeutic Drug Monitoring with the Use of Interstitial Fluid and Microneedles Technology","year":2017,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":92,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; University of Alberta","funders":"","keywords":"Therapeutic drug monitoring; Drug; Interstitial fluid; Intensive care medicine; Medicine; Biomedical engineering; Pharmacology; Pathology","retraction":null,"screen_n_in":null,"score":{"opus":0.4745928844311885,"gpt":0.5124721242419804,"spread":0.03787923981079189,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005550194,0.0007270244,0.001397425,0.0003564145,0.000790126,0.00007568092,0.001057289,0.0005745072,0.00006298806],"category_scores_gemma":[0.00006404293,0.0005088305,0.0002388289,0.0002950406,0.002026606,0.0003009497,0.0004175942,0.002475543,0.00002618173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840638,"about_ca_system_score_gemma":0.0002425216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000136044,"about_ca_topic_score_gemma":0.00000657258,"domain_scores_codex":[0.9970942,0.00060038,0.0007687886,0.0005918568,0.0002600622,0.000684723],"domain_scores_gemma":[0.9970362,0.0009891952,0.0009076185,0.0007200149,0.0001880784,0.0001588577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001453294,0.0001238791,0.0003362191,0.005594076,0.001611769,0.00005582119,0.0003689008,0.0001074958,0.0002466355,0.0001962981,0.0004220128,0.9907916],"study_design_scores_gemma":[0.0007535103,0.00005665231,0.00000389377,0.002902437,0.004456606,0.0001852594,0.0001193277,0.000241015,0.001142878,0.0000250952,0.9896123,0.0005009762],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003269696,0.9953649,0.0007063067,0.0003786418,0.001471037,0.001331825,0.0001965714,0.0001083572,0.0001154069],"genre_scores_gemma":[0.005566926,0.9921796,0.0008507677,0.0001814453,0.0003803626,0.0001557342,0.00002397244,0.0001170678,0.0005440735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9902906,"threshold_uncertainty_score":0.9998258,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3123280459","doi":"10.3390/pharmaceutics13020148","title":"Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":91,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Fluoxetine; CYP2D6; Pharmacology; Cytochrome P450; CYP2C9; Drug; Pharmacokinetics; Metabolite; Drug interaction; Chemistry; Active metabolite; CYP2C19; CYP3A; CYP3A4; Enzyme; Medicine; Biochemistry; Receptor; Serotonin","retraction":null,"screen_n_in":null,"score":{"opus":0.3525165209959286,"gpt":0.5544263198431747,"spread":0.2019097988472461,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002863749,0.001057147,0.002619455,0.0003722713,0.0004862484,0.0001426368,0.0009367561,0.001177169,0.001902824],"category_scores_gemma":[0.0003935189,0.0008004095,0.001194415,0.001319183,0.0004581318,0.0002091125,0.0006413679,0.003624829,0.0002891407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001530896,"about_ca_system_score_gemma":0.001037256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000641211,"about_ca_topic_score_gemma":0.000001153557,"domain_scores_codex":[0.9921784,0.003313414,0.001969383,0.0008420462,0.0006687748,0.001027925],"domain_scores_gemma":[0.9943617,0.002366416,0.001554607,0.0007297347,0.0004834493,0.0005040895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001563621,0.000555867,0.000004833981,0.007478083,0.001557434,0.0002008039,0.0003277964,0.00003945202,0.002920934,0.003514306,0.00309,0.9802949],"study_design_scores_gemma":[0.001078099,0.0000213239,5.694937e-7,0.001636216,0.007472908,0.0001697614,0.0001102544,0.001137002,0.01178016,0.0002332947,0.9756104,0.0007500537],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002281009,0.9879153,0.0002445189,0.0002309987,0.004974097,0.001513264,0.0006750759,0.0001349463,0.004083733],"genre_scores_gemma":[0.001270908,0.994024,0.0002473901,0.001628894,0.001267809,0.0002418404,0.0007616999,0.0001956503,0.0003617516],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9795448,"threshold_uncertainty_score":0.9994447,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2943690701","doi":"10.3390/pharmaceutics11050199","title":"DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report","year":2019,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"Fluorouracil; DPYD; Dihydropyrimidine dehydrogenase; Medicine; Dosing; Chemotherapy; Adverse effect; Pharmacokinetics; Precision medicine; Pharmacogenetics; Therapeutic drug monitoring; Pharmacology; Drug; Oncology; Internal medicine; Intensive care medicine; Thymidylate synthase; Pathology; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.1680817600237587,"gpt":0.4698942140530452,"spread":0.3018124540292865,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002416145,0.0004387062,0.00217067,0.00006924175,0.00007760202,0.00001885642,0.00003989185,0.0001199536,0.0001235092],"category_scores_gemma":[0.00005668061,0.0003021364,0.0002270212,0.0001510462,0.00008472495,0.00002556024,0.00006338403,0.0003032123,0.00001393086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00012482,"about_ca_system_score_gemma":0.0002514065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001523896,"about_ca_topic_score_gemma":0.000003674797,"domain_scores_codex":[0.9985891,0.00005478531,0.0005037131,0.0004603874,0.0001609575,0.0002310471],"domain_scores_gemma":[0.9989676,0.0001420837,0.0002908005,0.0003386869,0.00008160686,0.0001792373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001737617,0.00005834851,0.00004964534,0.1310932,0.0006402032,0.01414274,0.00002583486,4.270448e-9,1.014981e-7,0.000001005656,0.002109697,0.8518618],"study_design_scores_gemma":[0.000886028,0.000132375,0.0000040734,0.01482684,0.01558521,0.05767432,0.000006510144,0.000006741647,0.000002692543,7.952846e-7,0.9106321,0.0002422574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003432922,0.9954412,0.000001357696,0.0007858021,0.0001592741,0.002173706,0.00007068681,0.00003956637,0.001294054],"genre_scores_gemma":[0.00002431526,0.995434,0.000185509,0.002140303,0.000114121,0.0001434517,0.00007533246,0.000056475,0.001826489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9085225,"threshold_uncertainty_score":0.9999431,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4309683849","doi":"10.3390/pharmaceutics14112520","title":"siRNA Functionalized Lipid Nanoparticles (LNPs) in Management of Diseases","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PEGylation; Small interfering RNA; Nanotechnology; RNA interference; Computational biology; Chemistry; Transfection; RNA; Biology; Materials science; Gene; Biochemistry; Polyethylene glycol","retraction":null,"screen_n_in":null,"score":{"opus":0.1027433500458705,"gpt":0.3881437505114561,"spread":0.2854004004655856,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169537,0.0002124653,0.0004434272,0.00008097984,0.00003154079,0.000008747875,0.0002886493,0.00007654807,0.0006214309],"category_scores_gemma":[0.000009876489,0.0002007113,0.000271378,0.0001650555,0.00004131894,0.000002286753,0.0002955432,0.0001283572,0.00002005032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003254171,"about_ca_system_score_gemma":0.00008303126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003107587,"about_ca_topic_score_gemma":0.000001031223,"domain_scores_codex":[0.998806,0.0001230286,0.0004032018,0.0003099091,0.000165348,0.0001925178],"domain_scores_gemma":[0.9994534,0.00002123752,0.0001675917,0.0002787413,0.00002077647,0.00005831141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007844975,0.0002567678,0.00004956025,0.007918806,0.0004967153,0.00002595923,0.000009738194,0.00003980279,0.0005517207,0.00005164145,0.002021907,0.9884989],"study_design_scores_gemma":[0.0003208495,0.00006185976,0.000007626078,0.000585944,0.0005539379,0.000006536784,0.00002829333,0.000008895729,0.0007152842,0.00001193812,0.9975014,0.0001974626],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001063755,0.9973871,0.000008985743,0.000006926712,0.000409667,0.0003206659,0.0001391084,0.000006769301,0.0006570087],"genre_scores_gemma":[0.0005989781,0.997282,0.00004224189,0.00005892438,0.0001025129,0.000147815,0.0004447485,0.00002780522,0.001294978],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9954795,"threshold_uncertainty_score":0.818477,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4395011848","doi":"10.3390/pharmaceutics16040569","title":"Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Lebanese International University","keywords":"Bioavailability; Chemistry; Computer science; Pharmacology; Medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.08606295858566788,"gpt":0.4069473217027937,"spread":0.3208843631171258,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001456341,0.0002928284,0.0005369805,0.0001334216,0.0001423507,0.00004299665,0.0002480892,0.0001312659,0.001698709],"category_scores_gemma":[0.0005591222,0.0001573349,0.0001947968,0.0006920002,0.0004147367,0.0000879638,0.0001241035,0.0007824551,0.0000821078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009557411,"about_ca_system_score_gemma":0.0003838765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004502861,"about_ca_topic_score_gemma":0.00002998948,"domain_scores_codex":[0.9975337,0.000139252,0.0008393161,0.0004073901,0.0006340798,0.000446234],"domain_scores_gemma":[0.9980559,0.0007545007,0.0001099488,0.0006312875,0.0002182439,0.0002300647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002162317,0.0007516934,0.002401318,0.003899483,0.001467147,0.0007842932,0.006061671,0.0001725119,0.7907772,0.0006713234,0.1756675,0.0151835],"study_design_scores_gemma":[0.003707482,0.000694986,0.0005845286,0.001296612,0.001242167,0.0003177949,0.001557757,0.03546022,0.3291934,0.0001762311,0.6254476,0.0003212393],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8145699,0.01690838,0.001783911,0.1503074,0.004356388,0.002045776,0.00007303117,0.0003582093,0.009597034],"genre_scores_gemma":[0.9795356,0.003773891,0.0006045786,0.01023428,0.0007646796,0.00002443596,0.0000214032,0.00005315572,0.004987979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4615838,"threshold_uncertainty_score":0.9992139,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3008730699","doi":"10.3390/pharmaceutics12020186","title":"MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Wilfrid Laurier University; University of Ottawa","funders":"Agencia Estatal de Investigación; Ikerbasque, Basque Foundation for Science; Instituto de Salud Carlos III; Canadian Institutes of Health Research; European Regional Development Fund; Eusko Jaurlaritza; Deutsche Forschungsgemeinschaft","keywords":"Extracellular vesicles; Liposome; Chemistry; Nanoparticle; Vesicle; Extracellular; Extracellular vesicle; Biophysics; Nanotechnology; Cell biology; Microvesicles; Materials science; Biochemistry; Membrane; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.02234469320179328,"gpt":0.2808602667366106,"spread":0.2585155735348173,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001230201,0.0002761379,0.0001915188,0.00003717127,0.0001397567,0.00008669177,0.0001864167,0.0001120113,0.00001597661],"category_scores_gemma":[0.00007444657,0.0002782429,0.00006436947,0.0001329246,0.0001812978,0.00001573122,0.0002935876,0.000145452,0.000006012314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001348853,"about_ca_system_score_gemma":0.00003891716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005775522,"about_ca_topic_score_gemma":0.000001420468,"domain_scores_codex":[0.9984868,0.00008362614,0.0003006737,0.0005459519,0.0002215323,0.0003614572],"domain_scores_gemma":[0.9991439,0.00002395426,0.0001360698,0.0002497935,0.0000482098,0.0003980757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001247559,0.0001602057,0.006616777,0.0001163129,0.00008707026,0.00001060015,0.000474175,0.00002351965,0.9809315,0.00005451989,0.00008481032,0.01131574],"study_design_scores_gemma":[0.001236092,0.0002115485,0.007247782,0.000009995386,0.0001548494,0.000007648233,0.0003486855,0.004752218,0.9832711,0.00003580677,0.002394126,0.0003301127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722005,0.02553116,0.0006191368,0.001089188,0.0001046238,0.0003595976,0.00003263362,0.00004229062,0.00002092223],"genre_scores_gemma":[0.9973433,0.0009931379,0.0003913817,0.000844042,0.0001995968,0.00002455919,0.00008336862,0.00004634055,0.00007427964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02514285,"threshold_uncertainty_score":0.999967,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4212899432","doi":"10.3390/pharmaceutics14020398","title":"Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Medicine; Pandemic; Messenger RNA; Coronavirus disease 2019 (COVID-19); Disease; Biology; Genetics; Infectious disease (medical specialty); Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.1376401754319477,"gpt":0.3815385612212668,"spread":0.2438983857893191,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003296343,0.0004786356,0.00072284,0.000131897,0.0001732091,0.0000965404,0.0007331831,0.000243839,0.0002031665],"category_scores_gemma":[0.00002382006,0.0004496302,0.0004071987,0.0002942099,0.00004151552,0.000004202145,0.0003506791,0.0003583947,0.0002483658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065175,"about_ca_system_score_gemma":0.0004806344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001564526,"about_ca_topic_score_gemma":0.000003142336,"domain_scores_codex":[0.9976886,0.0002927705,0.0005510191,0.0006219343,0.0002962759,0.0005493902],"domain_scores_gemma":[0.9987101,0.00005644996,0.0002148205,0.0007063827,0.00009136681,0.000220909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001196449,0.000360377,0.00001826854,0.005824668,0.0009375273,0.00004904593,0.00005980084,0.001522527,0.01820706,0.0000161504,0.01668802,0.9561969],"study_design_scores_gemma":[0.000235978,0.0002806939,6.957436e-8,0.0004050375,0.0006448705,0.00002617915,0.00003388957,0.0003169997,0.0118974,8.571405e-7,0.9856282,0.0005298284],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008045117,0.9959008,0.0001162074,0.00003214865,0.001528451,0.0008301054,0.0002023459,0.00003856396,0.0005468276],"genre_scores_gemma":[0.001077617,0.9943659,0.00008182998,0.001482519,0.0006907864,0.0003477877,0.0003956967,0.0001086063,0.001449285],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9689402,"threshold_uncertainty_score":0.9997956,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4321252661","doi":"10.3390/pharmaceutics15020685","title":"Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development","year":2023,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Université de Montréal; Université de Sherbrooke","funders":"","keywords":"Retinitis pigmentosa; Medicine; Macular degeneration; Retinal degeneration; Disease; RPE65; Bioinformatics; Ophthalmology; Retinal; Retinal pigment epithelium; Pathology; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.1127603626282261,"gpt":0.3864727904962761,"spread":0.27371242786805,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003536066,0.0005018366,0.0006332892,0.0001157989,0.0001354607,0.00005983409,0.0002967487,0.0002385298,0.00003141361],"category_scores_gemma":[0.00003780297,0.0004506217,0.0001669941,0.0001896943,0.00008799857,0.000003291244,0.0003562988,0.0002560968,0.0001169359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003587052,"about_ca_system_score_gemma":0.0003971906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001557035,"about_ca_topic_score_gemma":0.00000639393,"domain_scores_codex":[0.9981372,0.00007715513,0.0005263227,0.0005841828,0.0002286614,0.0004464953],"domain_scores_gemma":[0.9992859,0.00004415039,0.0002161511,0.0002395058,0.00005153215,0.0001627524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001627044,0.0000740581,0.00003898969,0.006993269,0.000704046,0.00001151062,0.0002084682,4.268964e-7,0.0002146869,0.00004841454,0.004118659,0.9875712],"study_design_scores_gemma":[0.0003449184,0.00001718642,0.000009198683,0.000867374,0.0003012347,0.00002501563,0.00004341124,0.000003640047,0.0004723454,0.00001603556,0.9973333,0.0005663693],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004918622,0.9977203,0.0001836796,0.00006511613,0.0003822154,0.0006144847,0.0000357496,0.00004849601,0.0009008005],"genre_scores_gemma":[0.00005605559,0.9943008,0.0008310704,0.0002315103,0.0001678125,0.0001431919,0.0009299509,0.0001157575,0.003223827],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9932146,"threshold_uncertainty_score":0.9997945,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3210221100","doi":"10.3390/pharmaceutics13111837","title":"Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":76,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Queen's University; AstraZeneca; Queen's University Belfast; AstraZeneca UK","keywords":"Digital Light Processing; Fabrication; Materials science; Inkwell; 3D printing; Transdermal; Inkjet printing; Curing (chemistry); Digital printing; Nanotechnology; Engineering drawing; Computer science; Composite material; Engineering","retraction":null,"screen_n_in":null,"score":{"opus":0.1194880615950423,"gpt":0.4241560441728911,"spread":0.3046679825778488,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004745835,0.0002698096,0.0004275968,0.0001191213,0.0001835128,0.00003302647,0.0002761297,0.0002005315,0.000138399],"category_scores_gemma":[0.0002674594,0.0003042915,0.0001795963,0.0003698736,0.000200517,0.0003711522,0.0001334061,0.0004693522,0.000004293707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006189154,"about_ca_system_score_gemma":0.0001694852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.208312e-7,"about_ca_topic_score_gemma":4.679356e-7,"domain_scores_codex":[0.9979119,0.0001241744,0.0008294835,0.0003961692,0.0002287968,0.000509421],"domain_scores_gemma":[0.9981867,0.0003927335,0.0005466226,0.0002037333,0.0005346216,0.000135562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003984923,0.0008977118,0.007100923,0.00190116,0.0004507233,0.00002008747,0.001863659,0.4544849,0.4013138,0.0001227077,0.00006477506,0.131381],"study_design_scores_gemma":[0.001978453,0.00004150267,0.000020173,0.0001085261,0.0003177558,0.00001680473,0.0003781033,0.2179792,0.7605149,0.00006655964,0.0183178,0.0002602143],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.417073,0.002807766,0.5723853,0.0004484342,0.001410219,0.001243137,0.0002628518,0.0001365057,0.004232839],"genre_scores_gemma":[0.8996833,0.000421996,0.09898034,0.0003685144,0.0001025277,0.00004251141,0.0000805737,0.00005869821,0.0002615578],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4826103,"threshold_uncertainty_score":0.9999409,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4390404100","doi":"10.3390/pharmaceutics16010058","title":"Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":73,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Laurentian University","funders":"","keywords":"Drug delivery; Nasal administration; Nanotechnology; Medicine; Disease; Pharmacology; Materials science; Pathology","retraction":null,"screen_n_in":null,"score":{"opus":0.1499911509435538,"gpt":0.4335280330465608,"spread":0.283536882103007,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008851122,0.000377117,0.0003808143,0.0003717616,0.0002351904,0.00001693901,0.0003873574,0.0002197561,0.0000417694],"category_scores_gemma":[0.00003423196,0.0004093192,0.00008297902,0.0004362509,0.0003034766,0.000335776,0.0002332712,0.0005684923,0.00009035247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008541143,"about_ca_system_score_gemma":0.00003275567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002712078,"about_ca_topic_score_gemma":0.00002701564,"domain_scores_codex":[0.9974406,0.0002453429,0.000486338,0.000683792,0.0002007883,0.0009431415],"domain_scores_gemma":[0.9985635,0.0005832308,0.0001398622,0.0002652317,0.00006375511,0.0003844358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001744127,0.0004994998,0.005953096,0.001472009,0.0005471947,0.0003651835,0.00143093,0.003734519,0.003250603,0.004961998,0.01573711,0.9603037],"study_design_scores_gemma":[0.003383977,0.00003887668,0.000236124,0.00004621995,0.0002747195,0.000006072863,0.001009582,0.02579353,0.007274791,0.00244088,0.9590167,0.0004784684],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3804356,0.5872833,0.000525773,0.01920096,0.003895143,0.004544964,0.001061478,0.001447216,0.001605588],"genre_scores_gemma":[0.6304559,0.3670475,0.0002545049,0.001044485,0.0001290203,0.000594369,0.0000866867,0.00006228605,0.000325277],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9598253,"threshold_uncertainty_score":0.9998358,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3082147155","doi":"10.3390/pharmaceutics12090827","title":"Miktoarm Star Polymers: Branched Architectures in Drug Delivery","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Advanced Polymer Synthesis and Characterization","field":"Chemistry","cited_by":72,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Drug delivery; Nanotechnology; Micelle; Amphiphile; Polymer; Materials science; Drug; Star polymer; Copolymer; Chemistry; Aqueous solution; Organic chemistry; Medicine; Pharmacology","retraction":null,"screen_n_in":null,"score":{"opus":0.0524800342297136,"gpt":0.3447381091095015,"spread":0.2922580748797879,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008076098,0.0006557053,0.001428948,0.0001551589,0.00006129367,0.00005172181,0.0005409057,0.000256887,0.001492103],"category_scores_gemma":[0.00003584658,0.0006213754,0.0004169352,0.0003346282,0.00006772767,0.00006419356,0.0001604768,0.001007064,0.0000976337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793789,"about_ca_system_score_gemma":0.0002331214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000201948,"about_ca_topic_score_gemma":0.00001018962,"domain_scores_codex":[0.9976519,0.000102537,0.0007971839,0.0006066273,0.0002952349,0.0005465326],"domain_scores_gemma":[0.9986511,0.0002573341,0.0004404481,0.0003873055,0.00002076986,0.0002429984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002184197,0.00006898031,0.000005831647,0.01223578,0.0001405797,0.0000679159,0.0003085776,0.000001507998,0.0009823536,0.000006511618,0.00004469869,0.9861154],"study_design_scores_gemma":[0.0002892009,0.000002920351,3.446999e-7,0.003607845,0.0005300281,0.00001694831,0.00003716788,0.0000940406,0.009735551,0.00001478923,0.9850718,0.0005993938],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00027785,0.9970882,0.00001921775,0.00007232451,0.0002381151,0.0002156275,0.0003602572,0.0001387151,0.001589722],"genre_scores_gemma":[0.0004354239,0.9974558,0.0001360611,0.000264827,0.0006661044,0.00007842107,0.0003761166,0.0001579187,0.0004292699],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.985516,"threshold_uncertainty_score":0.9996238,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3000135183","doi":"10.3390/pharmaceutics12010074","title":"A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":71,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"U.S. Food and Drug Administration; Hamilton Health Sciences Foundation; Fonds Wetenschappelijk Onderzoek; American Association of Pharmaceutical Scientists","keywords":"IVIVC; Physiologically based pharmacokinetic modelling; Pharmacokinetics; In vivo; Biopharmaceutics; Pharmacology; Bioequivalence; Computer science; Drug; Dissolution testing; Biochemical engineering; Chemistry; Medicine; Biopharmaceutics Classification System; In vitro; Engineering","retraction":null,"screen_n_in":null,"score":{"opus":0.3551299014290869,"gpt":0.4343325597526548,"spread":0.07920265832356788,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00192657,0.0006929552,0.0009630209,0.0002127023,0.0003538516,0.00008808789,0.001756635,0.0002891616,0.0002864421],"category_scores_gemma":[0.0002499726,0.0005822588,0.0001967995,0.001309058,0.000194236,0.0002733885,0.0004578683,0.001527044,0.0001688253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001452193,"about_ca_system_score_gemma":0.0003441935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009975111,"about_ca_topic_score_gemma":0.00003187202,"domain_scores_codex":[0.994245,0.001471626,0.001316995,0.001221917,0.0006761457,0.001068298],"domain_scores_gemma":[0.9968759,0.0005496986,0.0003327367,0.0007207387,0.0003551865,0.001165754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00468348,0.001861653,0.002674708,0.0006617616,0.0002217573,0.00004006457,0.007099268,0.5989618,0.3792184,0.0002359619,0.0008781353,0.003462968],"study_design_scores_gemma":[0.00197151,0.000347867,0.0001422213,0.00005608833,0.0002506132,0.000004999139,0.0006456372,0.8034908,0.1782743,0.00005877489,0.01413837,0.0006188446],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864358,0.0002769427,0.004602791,0.003165288,0.00107942,0.002685178,0.0006406844,0.0002283172,0.0008856303],"genre_scores_gemma":[0.9724658,0.00009595029,0.004581557,0.02170481,0.0006246125,0.0002871245,0.00008071349,0.000084488,0.0000750073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.204529,"threshold_uncertainty_score":0.9996629,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2915232825","doi":"10.3390/pharmaceutics11030099","title":"The Development of Oral Amphotericin B to Treat Systemic Fungal and Parasitic Infections: Has the Myth Been Finally Realized?","year":2019,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Bill and Melinda Gates Foundation","keywords":"Amphotericin B; Bioavailability; Medicine; Antifungal; Pharmacology; Candida infections; Intensive care medicine; Dermatology","retraction":null,"screen_n_in":null,"score":{"opus":0.09711865387655787,"gpt":0.3928069126904485,"spread":0.2956882588138907,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007548807,0.0001470414,0.0002802621,0.00006977413,0.0003425323,0.00005212026,0.0001403011,0.0000329521,0.00001928136],"category_scores_gemma":[0.0001497239,0.00007945462,0.00004508797,0.0002310598,0.0001547053,0.0000413468,0.0001167695,0.000205379,0.0000674278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001426501,"about_ca_system_score_gemma":0.0001779532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005878121,"about_ca_topic_score_gemma":0.0000534388,"domain_scores_codex":[0.9986455,0.0001104358,0.000342347,0.0001885116,0.0003919938,0.0003211386],"domain_scores_gemma":[0.9989471,0.0003980628,0.00007875199,0.000287721,0.0001648116,0.000123598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002423628,0.0007226347,0.6386887,0.002659162,0.001871053,0.00006644586,0.02769546,0.0001957433,0.1766278,0.0007508439,0.01690563,0.1313929],"study_design_scores_gemma":[0.0101097,0.001992993,0.3609524,0.001229515,0.001150557,0.0009734678,0.008184417,0.002858386,0.1215836,0.0001824111,0.4900121,0.0007703711],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989777,0.001712658,0.0001444624,0.005703856,0.0001282433,0.001208933,0.000006990081,0.00003155369,0.001286319],"genre_scores_gemma":[0.996151,0.001016996,0.000457223,0.0006087821,0.00004179151,0.00008890931,0.000002860101,0.00001887707,0.001613576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4731065,"threshold_uncertainty_score":0.3240065,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2997850277","doi":"10.3390/pharmaceutics12010038","title":"Docetaxel-Loaded Disulfide Cross-Linked Nanoparticles Derived from Thiolated Sodium Alginate for Colon Cancer Drug Delivery","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":64,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Universiti Sains Malaysia; Ministry of Education, India; Ministry of Higher Education, Malaysia","keywords":"Zeta potential; Dynamic light scattering; Nanoparticle; Chemistry; Drug delivery; Sonication; Dispersity; Conjugated system; Drug carrier; Nuclear chemistry; Biophysics; Materials science; Nanotechnology; Polymer; Polymer chemistry; Organic chemistry; Chromatography","retraction":null,"screen_n_in":null,"score":{"opus":0.05702451660925115,"gpt":0.3346967317311554,"spread":0.2776722151219042,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004686378,0.0004483674,0.000536046,0.00005535026,0.0004142973,0.000352518,0.0007213316,0.0001355707,0.0007685344],"category_scores_gemma":[0.0002182175,0.0004416763,0.0001855281,0.0003681571,0.0002384331,0.0006155866,0.0002819743,0.0002943626,0.0006039312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944579,"about_ca_system_score_gemma":0.0002920853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003617018,"about_ca_topic_score_gemma":0.00004389009,"domain_scores_codex":[0.9965554,0.0002297829,0.0007529177,0.0008758949,0.0005005648,0.001085451],"domain_scores_gemma":[0.9976693,0.0005678589,0.0003332336,0.0003859891,0.0003937535,0.0006499125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001646104,0.0001625801,0.002415729,0.00009743916,0.00007905478,0.00003432919,0.001486127,0.002356485,0.9892777,0.00002434424,0.001561858,0.0008582285],"study_design_scores_gemma":[0.004425853,0.00007131582,0.0007163677,0.00004210634,0.0002839218,0.000001295,0.0001157135,0.05872878,0.9299242,0.0002503321,0.004905785,0.0005343569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885693,0.00224816,0.000610932,0.00492123,0.00116778,0.001060064,0.0008365993,0.0005637185,0.00002218764],"genre_scores_gemma":[0.9920506,0.0001812349,0.001558217,0.005309158,0.0004568023,0.0002435035,0.00005524267,0.00009109826,0.00005409677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05935355,"threshold_uncertainty_score":0.9998035,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2591295589","doi":"10.3390/pharmaceutics9010009","title":"Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target","year":2017,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Lung; Hydroxyeicosatetraenoic acid; Kidney; Medicine; Internal medicine; Chemistry; Biochemistry; Arachidonic acid","retraction":null,"screen_n_in":null,"score":{"opus":0.2090904553886902,"gpt":0.4972978398233645,"spread":0.2882073844346743,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001209576,0.0003770376,0.000969758,0.0001081617,0.0001920496,0.00004288073,0.0009262338,0.0004422031,0.00003210029],"category_scores_gemma":[0.0001333844,0.0002733402,0.0003246926,0.0001123737,0.0003223795,0.00001010023,0.000260734,0.0006527047,0.000004080493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001293843,"about_ca_system_score_gemma":0.0003448013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005473935,"about_ca_topic_score_gemma":0.000009955322,"domain_scores_codex":[0.9973342,0.0007788531,0.0008031824,0.0005856439,0.0001323675,0.0003657582],"domain_scores_gemma":[0.998172,0.0001409812,0.0005331488,0.0008572855,0.00008631788,0.0002102967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003037939,0.0004888434,0.0009177646,0.003018623,0.0004921178,0.00002380141,0.00009640379,0.000001394877,0.005034148,0.0002476398,0.00926257,0.9803863],"study_design_scores_gemma":[0.0005682957,0.0001346453,0.00009684147,0.0002572933,0.0007746125,0.0001111407,0.00001096371,0.000229551,0.0002424703,0.00007892057,0.9971927,0.0003025041],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004141974,0.9968283,0.00006390957,0.001105687,0.0003445995,0.0007614524,0.0001998072,0.000009533557,0.0002724745],"genre_scores_gemma":[0.009577855,0.9853095,0.0001700406,0.003820428,0.0004145918,0.00008082128,0.0004932234,0.00005488025,0.00007859597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9879302,"threshold_uncertainty_score":0.9999719,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4200051455","doi":"10.3390/pharmaceutics14010041","title":"Nanomedicine in Hepatocellular Carcinoma: A New Frontier in Targeted Cancer Treatment","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":63,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital; University Health Network","funders":"Mitacs; Canadian Liver Foundation","keywords":"Hepatocellular carcinoma; Nanomedicine; Medicine; Liver cancer; Oncology; Cancer; Internal medicine; Cancer research; Nanotechnology","retraction":null,"screen_n_in":null,"score":{"opus":0.1074862821075515,"gpt":0.3757289789021574,"spread":0.2682426967946059,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004112912,0.0005851789,0.002071436,0.0003622531,0.00003522114,0.00004831685,0.0003708764,0.0002249258,0.001486292],"category_scores_gemma":[0.00004189988,0.0004922746,0.0002442237,0.0009248815,0.00006996388,0.0001108142,0.0001360771,0.0003594418,0.000216352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001883409,"about_ca_system_score_gemma":0.002263864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002394484,"about_ca_topic_score_gemma":0.000291109,"domain_scores_codex":[0.996657,0.0004489389,0.001013527,0.0007581064,0.0003718316,0.0007506122],"domain_scores_gemma":[0.9987242,0.0001422375,0.0002741628,0.0005066427,0.00005064822,0.0003021759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005995575,0.001023099,0.006106569,0.00710728,0.0001336156,0.00384789,0.0009641774,0.0001536045,0.007891261,0.00001786302,0.002939899,0.9697548],"study_design_scores_gemma":[0.002089302,0.00004479347,0.000009091728,0.004011489,0.0007134115,0.00001744756,0.00002694338,0.0009804374,0.01345934,0.00000591947,0.9781424,0.000499472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01912406,0.977891,0.00001423685,0.0001178297,0.00145931,0.001177824,0.0001318094,0.00004559917,0.00003837071],"genre_scores_gemma":[0.002704624,0.9951738,0.0002716806,0.0001465981,0.0003690629,0.0003230704,0.0001038059,0.00008281005,0.0008245147],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9752024,"threshold_uncertainty_score":0.9997529,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3018118152","doi":"10.3390/pharmaceutics12040389","title":"Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Providence Health Care Research Institute","funders":"Fogarty International Center; European Commission; National Health and Medical Research Council; Lung Foundation Australia; Rijksuniversiteit Groningen; U.S. Department of Veterans Affairs","keywords":"Senescence; Idiopathic pulmonary fibrosis; Wound healing; A549 cell; Lung; Cell growth; Cell biology; Fibroblast; Pathology; Biology; Immunology; Cancer research; Medicine; Cell culture; Internal medicine","retraction":null,"screen_n_in":null,"score":{"opus":0.02389742866730687,"gpt":0.3063114509825321,"spread":0.2824140223152252,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187634,0.0001212992,0.0002016558,0.00005071843,0.00004066826,0.00001728516,0.00004236698,0.00005917501,0.00001743943],"category_scores_gemma":[0.00003784148,0.0001169458,0.00005098014,0.000156559,0.00004426755,0.0001387048,0.0000347703,0.0001789059,0.000003111534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004072023,"about_ca_system_score_gemma":0.00008149262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002981923,"about_ca_topic_score_gemma":0.000005585872,"domain_scores_codex":[0.9990877,0.0000489638,0.0002960898,0.0002107189,0.0001900084,0.0001665169],"domain_scores_gemma":[0.9995727,0.00002017554,0.00008651304,0.00007837229,0.0000713769,0.0001708927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003800289,0.0002815691,0.06551971,0.003117053,0.00002866929,0.00006020006,0.003920454,0.0002506119,0.920511,0.00005215174,0.0001133504,0.002344928],"study_design_scores_gemma":[0.002745286,0.001641511,0.00707633,0.0007537724,0.0002851047,0.00003489888,0.0002883088,0.5849931,0.3992865,0.00004539303,0.002557101,0.0002926354],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935799,0.001071347,0.001498566,0.002996725,0.00008586508,0.00060225,0.00004712798,0.00002653014,0.00009168017],"genre_scores_gemma":[0.9980926,0.0003305337,0.0005946624,0.0006837651,0.0002077553,0.000009591684,0.00004005502,0.00001603468,0.00002503389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5847425,"threshold_uncertainty_score":0.476891,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4362561087","doi":"10.3390/pharmaceutics15041130","title":"Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies","year":2023,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Muscular Dystrophy Canada; Canadian Institutes of Health Research; Alberta Innovates; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Oligonucleotide; Nucleic acid; Gene delivery; Computational biology; Genetic enhancement; Peptide; DNA; Cell-penetrating peptide; Drug delivery; RNA; Cell; Chemistry; Nanotechnology; Gene; Biology; Biochemistry; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.1048472393110809,"gpt":0.3896001477782433,"spread":0.2847529084671623,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007585167,0.0003683531,0.0005749111,0.00007441986,0.0001301205,0.00007511602,0.000344232,0.0002589754,0.000002607781],"category_scores_gemma":[0.00005425534,0.0002934792,0.0002205287,0.0001979446,0.0002058576,0.00000965168,0.0001240955,0.0002804756,0.000003254416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003826509,"about_ca_system_score_gemma":0.000613019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002773167,"about_ca_topic_score_gemma":0.000006473776,"domain_scores_codex":[0.9980559,0.0004706463,0.0006079066,0.0004237254,0.000175502,0.0002663534],"domain_scores_gemma":[0.9985009,0.0003940036,0.0004075938,0.0003852941,0.0002486798,0.00006347543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007521518,0.00005597025,0.00004953524,0.01706395,0.0005257447,0.000003304772,0.00009791394,0.0009214882,0.9597677,0.00005371319,0.00002017551,0.02136529],"study_design_scores_gemma":[0.0005490211,0.0001150014,0.00001631996,0.004451531,0.002002775,0.0000224483,0.0004652658,0.002433628,0.9432012,0.00007263316,0.04594909,0.0007211179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1509747,0.8463926,0.001533118,0.00000489397,0.0001722138,0.000705165,0.0001114567,0.00002236837,0.00008347927],"genre_scores_gemma":[0.2013672,0.7978775,0.0002039017,0.0000585275,0.0001505861,0.00004780461,0.0002116165,0.00006853212,0.00001435885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.05039249,"threshold_uncertainty_score":0.9999517,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3113322471","doi":"10.3390/pharmaceutics12121232","title":"Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Corneal Surgery and Treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"","keywords":"Cornea; Drug delivery; Nanocarriers; Drug; Niosome; Targeted drug delivery; Self-healing hydrogels; Nanotechnology; Corneal disease; Corneal Diseases; Biomedical engineering; Pharmacology; Medicine; Materials science; Ophthalmology; Chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.1742019690636882,"gpt":0.4215457363808794,"spread":0.2473437673171912,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002706592,0.0004802616,0.002274203,0.00006006139,0.00009828493,0.00002025547,0.0001548364,0.000106197,0.0002218483],"category_scores_gemma":[0.0001062056,0.0003625416,0.0009249747,0.0004666832,0.0000406254,0.00005265593,0.0000835989,0.0003331163,0.0005811109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028463,"about_ca_system_score_gemma":0.0004832432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001101696,"about_ca_topic_score_gemma":0.00000186015,"domain_scores_codex":[0.998003,0.0001028133,0.0006742473,0.0004867014,0.0002358634,0.000497381],"domain_scores_gemma":[0.9984281,0.0003368394,0.0002831031,0.0003651011,0.0001045839,0.000482285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004122773,0.0001807002,0.0000152282,0.0776547,0.0005547379,0.0001575542,0.000007693892,1.077008e-8,0.000002018566,0.00001295152,0.0225399,0.8988333],"study_design_scores_gemma":[0.0007445249,0.00007402639,2.213276e-7,0.03023619,0.01332738,0.000122708,0.000001437097,0.00004809282,0.0002599483,0.00001816979,0.9548766,0.0002907197],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004905183,0.9947146,0.00000884573,0.0008776726,0.0003677938,0.003248739,0.000313817,0.0001284217,0.0003352691],"genre_scores_gemma":[0.0000285695,0.9961848,0.0002377094,0.001550828,0.000233368,0.0004662581,0.0003475788,0.00009236146,0.0008585501],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9323367,"threshold_uncertainty_score":0.9998826,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3162340133","doi":"10.3390/pharmaceutics13050715","title":"Development of [225Ac]Ac-PSMA-I&amp;T for Targeted Alpha Therapy According to GMP Guidelines for Treatment of mCRPC","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"TRIUMF","funders":"KWF Kankerbestrijding; Erasmus Medisch Centrum","keywords":"Radionuclide therapy; Chemistry; Yield (engineering); Radiochemistry; Prostate cancer; Chromatography; Nuclear medicine; Medicine; Cancer; Internal medicine; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.4972092962117038,"gpt":0.5363240987843058,"spread":0.03911480257260197,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001795439,0.0002004128,0.0004623282,0.00004824786,0.00009195486,0.000007288842,0.0001031199,0.00007169865,0.00007914931],"category_scores_gemma":[0.00019833,0.0001747896,0.0001994961,0.0002607773,0.00003794876,0.0000263721,0.00002348479,0.0000429605,0.000003654045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031758,"about_ca_system_score_gemma":0.0003315614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001263643,"about_ca_topic_score_gemma":0.000001022912,"domain_scores_codex":[0.998547,0.00001135974,0.0006784303,0.0002924428,0.0001852123,0.0002855773],"domain_scores_gemma":[0.9982312,0.0002060803,0.0001362063,0.0002731084,0.0009148798,0.0002385189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005030693,0.0006722532,0.0003861103,0.0003104414,0.0003222934,0.00000115863,0.000426433,0.00004594494,0.9104272,0.00007791181,0.0009946845,0.0858325],"study_design_scores_gemma":[0.002469119,0.00006257436,0.0000338002,0.00003240105,0.0001400024,0.000005699002,0.0001518884,0.00069372,0.5773756,0.00003657214,0.4189062,0.00009244336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505437,0.004046801,0.0356455,0.006576467,0.0002145939,0.002312937,0.0002858508,0.00006436018,0.0003098117],"genre_scores_gemma":[0.5996451,0.00114817,0.3945474,0.001646081,0.0004470268,0.0008646739,0.0003706358,0.00005511474,0.0012757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4179115,"threshold_uncertainty_score":0.7127712,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4297222694","doi":"10.3390/pharmaceutics14102043","title":"Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Faculté de pharmacie, Université de Montréal; Uniwersytet Jagielloński w Krakowie","keywords":"Formulary; Intensive care medicine; Medicine; Dosage form; Computer science; Risk analysis (engineering); Management science; Pharmacology; Engineering","retraction":null,"screen_n_in":null,"score":{"opus":0.1809835165543112,"gpt":0.4343199652176243,"spread":0.2533364486633131,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001256631,0.0005351658,0.001351285,0.0001976525,0.0002545439,0.0000148005,0.0004667136,0.0003489818,0.0002623038],"category_scores_gemma":[0.00002766572,0.0003418286,0.0003690663,0.0003858599,0.0003608669,0.0002012192,0.0003169798,0.001625237,0.000006727903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468678,"about_ca_system_score_gemma":0.000282942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004271824,"about_ca_topic_score_gemma":0.00001226418,"domain_scores_codex":[0.9966292,0.001086998,0.000926541,0.0004782136,0.0004685054,0.0004104941],"domain_scores_gemma":[0.997502,0.0004853561,0.001309797,0.0004191007,0.0001325267,0.00015119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002911225,0.0004631926,0.00005956427,0.03935647,0.001106422,0.0000110912,0.008539231,0.00005874021,0.00001947355,0.001251166,0.0001357657,0.9487078],"study_design_scores_gemma":[0.0009187231,0.0001993164,0.00001260408,0.0009901393,0.001509555,0.00007734328,0.001470316,0.0001408351,0.0006348857,0.0001065346,0.9935748,0.0003649354],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009394974,0.9886177,0.000003603586,0.0002249069,0.0007545315,0.0039998,0.0003980448,0.00004657689,0.005015398],"genre_scores_gemma":[0.005029944,0.9936916,0.00002082845,0.0000602725,0.0003239211,0.0004042435,0.00004757798,0.00006626514,0.0003553384],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.993439,"threshold_uncertainty_score":0.9999034,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2166846335","doi":"10.3390/pharmaceutics3030458","title":"Fourth Generation Phosphorus-Containing Dendrimers: Prospective Drug and Gene Delivery Carrier","year":2011,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"","keywords":"Dendrimer; Transfection; Chemistry; Zeta potential; Gene delivery; Cytotoxicity; Circular dichroism; Drug; Biophysics; Drug delivery; Fluorescence; Biochemistry; In vitro; Biology; Pharmacology; Gene; Nanotechnology; Nanoparticle; Organic chemistry; Materials science","retraction":null,"screen_n_in":null,"score":{"opus":0.05108202654787108,"gpt":0.2879665004245944,"spread":0.2368844738767233,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256632,0.0001692586,0.000116118,0.00003531361,0.0001095264,0.00002786386,0.0001191962,0.00007941951,0.0000401066],"category_scores_gemma":[0.00001292778,0.0001710527,0.00005365168,0.0000493049,0.00007297777,0.00001280286,0.0001092641,0.0001096133,0.00001252708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001810609,"about_ca_system_score_gemma":0.00005666259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007059664,"about_ca_topic_score_gemma":0.0000427677,"domain_scores_codex":[0.9991133,0.00003932041,0.0001651019,0.0003463908,0.00009433314,0.0002416208],"domain_scores_gemma":[0.9995056,0.000004558717,0.0000649825,0.0001841748,0.0001288588,0.0001118161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002514666,0.00005424925,0.04240313,0.000008160253,0.0001858482,0.00001538039,0.001466117,0.00002085661,0.9460083,0.00005357042,0.001259448,0.008273439],"study_design_scores_gemma":[0.0005677282,0.0001760926,0.002203757,0.000005678941,0.00007215689,0.00002568512,0.0003078555,0.0009341819,0.9899226,0.00003942049,0.005507695,0.0002370909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928547,0.004389486,0.0007838339,0.00001961923,0.0002943949,0.0001838897,0.00002445836,0.00001653769,0.00143305],"genre_scores_gemma":[0.9946643,0.002270155,0.001631349,0.000574405,0.0003332823,0.00002464583,0.00005142925,0.00002396573,0.0004264422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04391432,"threshold_uncertainty_score":0.6975325,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4285090011","doi":"10.3390/pharmaceutics14071452","title":"Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"National Research Council Canada","funders":"","keywords":"Blood–brain barrier; Transcytosis; In vivo; Pharmacology; Receptor; Drug delivery; Chemistry; Cell biology; Biophysics; Biology; Internal medicine; Central nervous system; Endocrinology; Medicine; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.07142232288898082,"gpt":0.3242077955547102,"spread":0.2527854726657294,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992567,0.0002063205,0.0002644999,0.0001100275,0.0003320002,0.00002289563,0.0005028583,0.00003094391,0.0005652743],"category_scores_gemma":[0.0002600827,0.0002140295,0.0001246269,0.0004760923,0.0001600522,0.0001384894,0.0006030552,0.0004827385,0.00004897192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006246633,"about_ca_system_score_gemma":0.00004970979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000137591,"about_ca_topic_score_gemma":2.969896e-7,"domain_scores_codex":[0.9977717,0.0005318655,0.0003915045,0.0004810682,0.0003749724,0.0004488505],"domain_scores_gemma":[0.9988733,0.000528391,0.0002446106,0.0001798211,0.00005318386,0.0001207271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729155,0.0003179358,0.0004084925,0.00004449204,0.000008147425,0.0000386723,0.0003506542,0.00009177258,0.9945245,0.0008286564,0.002408323,0.0008054829],"study_design_scores_gemma":[0.000670731,0.0003765214,0.000123069,0.000007170264,0.000009721925,0.00001734621,0.000146368,0.0005533739,0.8022707,0.0003481473,0.1952363,0.0002406159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972963,0.0001470481,0.00002826173,0.0004088362,0.0007825255,0.0002231641,0.0002227851,0.00009932206,0.000791733],"genre_scores_gemma":[0.9934756,0.0001761754,0.0002877389,0.00571234,0.0001350219,0.000009940736,0.00001778969,0.00004899564,0.0001364661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192828,"threshold_uncertainty_score":0.8727868,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2936221687","doi":"10.3390/pharmaceutics11040179","title":"Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation","year":2019,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":53,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph; Grand River Hospital; University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Physiologically based pharmacokinetic modelling; Biodistribution; Pharmacokinetics; Chemistry; Pharmacology; Colloidal gold; Nanocarriers; Radiochemistry; Nanoparticle; Biochemistry; Nanotechnology; In vitro; Medicine; Drug delivery; Materials science; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.04141288327208516,"gpt":0.2956801195222443,"spread":0.2542672362501591,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970116,0.00009388582,0.0001401086,0.00004548774,0.00002540842,0.00002361802,0.00009708375,0.00002577418,0.00008916354],"category_scores_gemma":[0.00001114244,0.00007431175,0.00001803098,0.0001791997,0.00008291766,0.0001069545,0.00002693223,0.00005573843,0.00002182434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002545746,"about_ca_system_score_gemma":0.00001827934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001568447,"about_ca_topic_score_gemma":0.000003246802,"domain_scores_codex":[0.9992293,0.00004962693,0.0002304661,0.0001987987,0.0001200777,0.0001717594],"domain_scores_gemma":[0.9996345,0.00007697099,0.00008504756,0.0001014671,0.00005669111,0.00004530308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009878611,0.0001114596,0.00262051,0.0000388386,0.000002594029,3.035909e-7,0.00008195206,0.0155715,0.980489,0.0003325444,0.00000452518,0.0006480537],"study_design_scores_gemma":[0.0004978653,0.00003551218,0.0008517,0.00003463286,0.00001735452,6.897439e-7,0.00008302687,0.2763014,0.7219297,0.00009406509,0.00007884784,0.00007526438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978483,0.0002335352,0.001304389,0.000218807,0.00002846767,0.0002481572,0.00002622446,0.00002809038,0.00006396918],"genre_scores_gemma":[0.9983846,0.00005697157,0.001441453,0.00006784841,0.00001169876,0.00002079818,0.000005299508,0.000006484423,0.000004836368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2607299,"threshold_uncertainty_score":0.3030345,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2967888334","doi":"10.3390/pharmaceutics11080404","title":"Extracellular Vesicles as a Potential Therapy for Neonatal Conditions: State of the Art and Challenges in Clinical Translation","year":2019,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Sick Kids Foundation","keywords":"Regenerative medicine; Paracrine signalling; Stem cell; Population; Cell therapy; microRNA; Medicine; Extracellular vesicles; Bioinformatics; Neuroscience; Translational medicine; Intensive care medicine; Genetic enhancement; Regeneration (biology); Biology; Cell biology; Pathology; Internal medicine; Gene; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.1915177579611115,"gpt":0.434765524218286,"spread":0.2432477662571745,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005669257,0.0002551085,0.0005343274,0.00004905881,0.00003592467,0.00001404724,0.0002815734,0.0002437884,0.000007797406],"category_scores_gemma":[0.00005557576,0.000202964,0.000452276,0.00006046338,0.000188698,0.000005731601,0.00007027378,0.0002379128,0.000005831535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009722584,"about_ca_system_score_gemma":0.0002204147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.559553e-7,"about_ca_topic_score_gemma":0.000002647782,"domain_scores_codex":[0.998229,0.0003389535,0.0006750602,0.0004164239,0.0001410187,0.0001995925],"domain_scores_gemma":[0.9990234,0.0001179412,0.0003453782,0.0003932957,0.00005058828,0.00006944395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000101747,0.0001383519,0.00001316175,0.003830499,0.0001754,0.000003580323,0.00003033599,0.00001303883,0.002087807,0.00005158914,0.0000503884,0.9935041],"study_design_scores_gemma":[0.00125883,0.0001183686,0.0000216369,0.000573027,0.0003635949,0.00002113663,0.0000141386,0.0001582595,0.002617707,0.0002605301,0.9943643,0.000228487],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003790896,0.9936435,0.0001718273,0.00009580398,0.000280921,0.001663019,0.0003226721,0.000005402238,0.00002600367],"genre_scores_gemma":[0.003381545,0.9955978,0.0002098401,0.00003678858,0.0001473912,0.0000890669,0.0003211441,0.00005289185,0.000163526],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9943139,"threshold_uncertainty_score":0.8276631,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4210632106","doi":"10.3390/pharmaceutics14020297","title":"Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Polymer Surface Interaction Studies","field":"Materials Science","cited_by":51,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba","funders":"","keywords":"Encapsulation (networking); Cell encapsulation; Nanotechnology; Drug delivery; Polyelectrolyte; Materials science; Chemistry; Cell; Computer science; Polymer; Biochemistry; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.1505331433052229,"gpt":0.3953398314024602,"spread":0.2448066880972373,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007131541,0.0003277274,0.0005657551,0.00008763641,0.0004326609,0.00005347523,0.0004524438,0.00008294955,0.0007229511],"category_scores_gemma":[0.00002312141,0.000257272,0.0001801454,0.00013877,0.0001197948,0.0001189861,0.0002813749,0.0003656768,0.00006766773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005884221,"about_ca_system_score_gemma":0.0001898041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004519466,"about_ca_topic_score_gemma":0.000004349416,"domain_scores_codex":[0.998257,0.0002552119,0.0004751129,0.0004548187,0.0002565698,0.0003012565],"domain_scores_gemma":[0.9982135,0.000779323,0.0004813338,0.0003848903,0.00006378109,0.00007720066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001673981,0.0001833495,0.000003232798,0.00711578,0.0001278147,0.000001193674,0.0004787606,0.000003513135,0.03449848,0.0001176387,0.2322925,0.725161],"study_design_scores_gemma":[0.0000948925,0.000007985527,6.318182e-8,0.00009955111,0.0006427115,0.00000969674,0.00004444257,0.00003724001,0.02029934,0.00002588943,0.9784773,0.0002608735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008861787,0.992014,0.002439611,0.0001117022,0.001159414,0.002721828,0.000604053,0.0001162778,0.0008242579],"genre_scores_gemma":[0.0001715555,0.98935,0.0004866786,0.0002715986,0.0001512636,0.007040572,0.00008439348,0.00006053225,0.002383394],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7461848,"threshold_uncertainty_score":0.999988,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4212907496","doi":"10.3390/pharmaceutics14020445","title":"Prevalence and Risk Factors of Augmented Renal Clearance: A Systematic Review and Meta-Analysis","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Meta-analysis; CINAHL; Cochrane Library; Population; Intensive care unit; MEDLINE; Critically ill; Systematic review; Intensive care medicine; Emergency medicine; Pediatrics; Internal medicine; Psychological intervention; Psychiatry; Environmental health","retraction":null,"screen_n_in":null,"score":{"opus":0.2011327155966001,"gpt":0.4402530068666043,"spread":0.2391202912700042,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001031551,0.0005302267,0.007437698,0.0003132294,0.00009654299,0.00001923457,0.0002112731,0.0001021777,0.001184363],"category_scores_gemma":[0.0002473358,0.0003496007,0.001720174,0.0008865332,0.0001383658,0.00003068483,0.0002374892,0.0007587028,0.000003677457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004640218,"about_ca_system_score_gemma":0.00008077454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009139334,"about_ca_topic_score_gemma":1.992232e-7,"domain_scores_codex":[0.9967291,0.0006290187,0.001338199,0.0005196964,0.0005229334,0.0002610123],"domain_scores_gemma":[0.9973025,0.0004817267,0.001322646,0.0005490399,0.00008657858,0.0002574536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000005997331,0.00008609828,0.00004705454,0.8307036,0.1677445,0.00001170919,0.00003467993,0.000001615983,2.818331e-7,0.000006111609,0.0000535927,0.001304786],"study_design_scores_gemma":[0.0002111343,0.00005967917,0.00001183689,0.01706401,0.8907684,0.00005576745,0.000006937889,0.0001854984,0.0000033949,8.115775e-7,0.09139094,0.0002415755],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003623874,0.9960189,0.00002539293,0.00003549793,0.00003371981,0.00314697,0.000619596,0.00002526328,0.00005834611],"genre_scores_gemma":[0.0002575254,0.9987158,0.0001004622,0.0001587634,0.00001507911,0.00005855072,0.00008215674,0.00005367324,0.0005579863],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8136396,"threshold_uncertainty_score":0.9998956,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2936350508","doi":"10.3390/pharmaceutics11040185","title":"Development and Characterization of Liposomal Formulations Containing Phytosterols Extracted from Canola Oil Deodorizer Distillate along with Tocopherols as Food Additives","year":2019,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan","funders":"Ministry of Agriculture - Saskatchewan","keywords":"Canola; Chemistry; Zeta potential; Chromatography; Sonication; Phytosterol; Liposome; Campesterol; Food science; Chemical engineering; Cholesterol; Sterol; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.03004219827185005,"gpt":0.288010123705169,"spread":0.257967925433319,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007677161,0.0001992101,0.0003666165,0.00007124458,0.00005850131,0.00002907671,0.00005185549,0.00007410815,0.0001625399],"category_scores_gemma":[0.00001844692,0.0001655879,0.00003293538,0.0001216078,0.00004184351,0.0002264262,0.00004267988,0.0001742847,0.00001469158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003245861,"about_ca_system_score_gemma":0.0001317478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001695912,"about_ca_topic_score_gemma":0.00002311304,"domain_scores_codex":[0.9988766,0.00003046083,0.0003649383,0.0002529912,0.0002503057,0.0002247044],"domain_scores_gemma":[0.9992367,0.00008073334,0.0002183183,0.0001628682,0.0001400238,0.0001613663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001246851,0.0001427411,0.1354636,0.0001759991,0.0003539218,0.000008597687,0.004755908,0.00000492074,0.7467146,0.00008065289,0.000001503852,0.1110507],"study_design_scores_gemma":[0.006318033,0.0002834502,0.7167646,0.0004445081,0.0002960531,0.00003516982,0.0002135453,0.0005603497,0.2353106,0.000008683888,0.03951641,0.0002485935],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998204,0.0001494177,0.000156174,0.0001056944,0.0001791836,0.0004545962,0.000137884,0.00004577444,0.0005672782],"genre_scores_gemma":[0.9969028,0.00007424455,0.001655591,0.000375398,0.0001840378,0.00004017126,0.000414491,0.00003495966,0.000318268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.581301,"threshold_uncertainty_score":0.675248,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}